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Sample records for fr09au10r pp 48055-48104

  1. PP-HBP改性PP/PVC的流变行为%Study on Rheologic Behavior of PP Grafted with Hyperbranched Poly (amide-ester)/PP/PVC Blends

    Institute of Scientific and Technical Information of China (English)

    刁建志; 宋晓红; 张建民; 彭政

    2006-01-01

    研究了聚丙烯接枝超支化聚(酰胺-酯)(PP-HBP)/PP/聚氯乙烯(PVC)共混体系的流变行为.讨论了PP-HBP用量对PP/PVC共混体系流变行为的影响.结果表明,当PP/PVC共混体系中加入PP-HBP不大于5份时,PP/PVC/PP-HBP共混体系的表观粘度大于PP/PVC共混体系的;当加入PP-HBP大于5份时,PP/PVC/PP-HBP共混体系的表观粘度小于PP/PVC共混体系的;随着温度升高,PP/PVC和PP/PVC/PP-HBP共混体系表观粘度减小.

  2. STUDY ON PP/PVC/PP-HBP BLENDS%PP/PVC/PP-HBP共混体系研究

    Institute of Scientific and Technical Information of China (English)

    刁建志; 巴信武; 丁海涛; 李春子

    2005-01-01

    研究了聚丙烯接枝超支化聚(酰胺-酯)(PP-HBP)对聚丙烯/聚氯乙烯(PP/PVC)共混体系力学性能的影响.结果表明,在PP/PVC(质量比为70/30)共混体系中加入5份PP-HBP时,共混物拉伸强度和冲击强度均出现最大值.扫描电子显微镜(SEM)研究结果证明,PP-HBP增强了PP/PVC的界面粘结作用,减小了共混体系的相分离程度.

  3. Matrix Theory of pp Waves

    CERN Document Server

    Michelson, J

    2004-01-01

    The Matrix Theory that has been proposed for various pp wave backgrounds is discussed. Particular emphasis is on the existence of novel nontrivial supersymmetric solutions of the Matrix Theory. These correspond to branes of various shapes (ellipsoidal, paraboloidal, and possibly hyperboloidal) that are unexpected from previous studies of branes in pp wave geometries.

  4. Extracting the Odderon from $pp$ and $\\bar pp$ scattering data

    CERN Document Server

    Ster, Andras; Csorgo, Tamas

    2015-01-01

    Starting from a simple empirical parametrization of the scattering amplitude, successfully describing the dip-bump structure of elastic $pp$ scattering in $t$ at fixed values of $s$, we construct a toy model interpolating between missing energy gaps to extract the Odderon contribution from the difference between $\\bar pp$ and $pp$ elastic and total cross sections. The model is fitted to data from $\\sqrt s=23.5$ GeV to 7 TeV and used to extract the Odderon and its ratio to the Pomeron.

  5. (-p)p and pp Elastic Scattering at High Energies

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on the eikonalized Glauber representation of hadron-hadron scattering, we study the diffractive processes of -pp and pp elastic scattering at high energies. From our theoretical calculations and fits to the corresponding experimental data at high energies and all available momentum transfer, we find that the Pomeron exchange contributions play a significant role in description of differential cross section dσ/dt in the whole experimental domain. The Pomeron exchange contributions are related to multi-gluon exchanges in QCD, which are color singlet bound state of Reggeized gluons, such as tensor glueball and Odderon. Accordingly, we may claim that the -pp and pp diffractive processes at high energies s and moderate momentum transfer t would be a good tool to verify the existence of the color singlet multigluon bound states and to test QCD since QCD theory does predict the existence of these states. Therefore, we believe that the experimental measurement should be done for these diffractive processes.

  6. PP/共聚PP/POE共混体系的研究%Study of PP/Co-PP/POE Blend

    Institute of Scientific and Technical Information of China (English)

    刘西文; 纪立军; 王重

    2008-01-01

    研究了POE用量对T30S/POE和F401/POE体系的力学性能、流动性能的影响,并研究了POE质量分数为15%的情况下,共聚PP用量对PP/共聚PP/POE共混体系的力学性能、流动性能的影响.结果表明:与T30S/POE相比,F401/POE体系的冲击强度提高比较显著,而两种共混体系的加工性能均较好;共聚PP在PP/共聚PP/POE体系中明显起到了协同增韧作用,其中,F401/EPS30R/POE共混体系的综合性能最好.

  7. On Weakly P.P. Rings

    Institute of Scientific and Technical Information of China (English)

    Xiang Yue-ming; Ouyang Lun-qun; Wang Shu-gui

    2015-01-01

    We introduce, in this paper, the right weakly p.p. rings as the generaliza-tion of right p.p. rings. It is shown that many properties of the right p.p. rings can be extended onto the right weakly p.p. rings. Relative examples are constructed. As applications, we also characterize the regular rings and the semisimple rings in terms of the right weakly p.p. rings.

  8. Comparison of Single Loop and Dual Loop PP Reactors and PP Product Development

    Institute of Scientific and Technical Information of China (English)

    Lu Yunfeng; Jiang Rong; Feng Suogui

    2003-01-01

    The present status of PP technology in China is presented. Through a review of single loop and dual loop PP reactor technology as well as development and utilization of PP products it is concluded that import of PP technology should be based on the demand of PP products and market trend with consideration of local conditions. The existing problems and future development of PP technology in China are discussed.

  9. Comparison of pp and pp interactions at $\\sqrt{s}$=53 GeV

    CERN Document Server

    Alpgard, K; Åsman, B; Berglund, S; Bertrand, D; Böckmann, Klaus; Booth, C N; Buffam, C; Burow, L; Carlson, Per J; Carter, J R; Chevalley, J L; Eckart, B; Ekspong, G; Fabre, Jean-Paul; French, K A; Gaudaen, J; Gijsen, M; Hospes, R; Johnson, D; Jon-And, K; Kokott, T; Leistam, L; MacKenzie, R; Maggs, M N; Meinke, R; Mulkens, H; Müller, T; Munday, D J; Odian, A; Rosenberg, M; Rushbrooke, John G; Saarikko, H; Saarikko, T; Tavernier, Stefaan; Triantis, F A; Von Holt, K; Walck, C; Ward, C P; Ward, D R; Weidberg, A R; White, T O; Wilquet, G; Yamdagni, N

    1982-01-01

    Results are presented from the first pp colliding beam runs at the CERN ISR, using the UA5 streamer chamber detector. pp interactions at \\sqrt{s}=53 GeV are compared with pp data taken in the same experiment. The results are in good agreement with extrapolations of low-energy pp data.

  10. High Energy (-p)p and pp Elastic Scatterings in QCD Inspired Model

    Institute of Scientific and Technical Information of China (English)

    LU Juan; MA Wei-Xing; HE Xiao-Rong

    2007-01-01

    We propose QCD inspired model to calculate (p)p and pp elastic scatterings at high energies in this paper.A calculation for total cross section of (p)p and pp is performed in which the contributions from gluon-gluon,quark-quark,and gluon-quark interactions are included.Our results show that the QCD inspired model gives a perfect fit to experimental data of total cross section both for (p)p and pp elastic scatterings at the whole energy region where experimental data existed at FNAL and CERN.

  11. Study of pp{yields}pp{eta} reaction at threshold; Etude de la reaction pp{yields}pp{eta} au seuil

    Energy Technology Data Exchange (ETDEWEB)

    Taleb, A.

    1994-11-01

    The {eta} production has been studied through the pp {yields} pp{eta} reaction at threshold. Data were taken at the Synchrotron of the ``Laboratoire National Saturne``. The detection in coincidence of the two protons scattered near 0 deg and analysed with the magnetic spectrometer SPES3 allows the reconstruction of missing mass spectra for the {eta} signature. A simulation program which takes into account all the experimental set up characteristics has been realized and tested through the pp {yields} d{pi}{sup +} reaction detected simultaneously with pp {yields} pp{eta}. The generated proton momentum spectra for pp {yields} pp{eta} show a pronounced {eta} mass dependence. This characteristic, connected to the kinematical properties of pp {yields} pp{eta} at threshold, is used to extract the mass of the meson {eta}. The obtained value, m{sub {eta}} = 547.65 {+-} 0.18 MeV, is in good agreement with measurement done recently through the pd {yields} {sup H}e{eta} reaction. The total cross section {sigma}{sub t} of pp {yields} pp{eta} measured at 1260, 1265 and 1300 MeV presents a strong energy dependence. This cross section increases less with energy than the phase-space. The influence of p-p and {eta}-p final state interactions in our measurements is studied. Our results are compared with theoretical predictions and assess the dominant character of the baryonic resonance N{sup *}(1535) in the {eta} mechanism production at threshold. These experimental results give an energy dependence which is not well reproduced by the theoretical predictions. This discrepancy could be an incorrect description of the {eta}-p interaction in the models. (author). 48 refs., 60 figs., 15 tabs.

  12. ppGpp: magic beyond RNA polymerase.

    Science.gov (United States)

    Dalebroux, Zachary D; Swanson, Michele S

    2012-02-16

    During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and its impact on promoter selection by RNAP, we discuss how bacteria exploit ppGpp to modulate the synthesis, stability or activity of proteins or regulatory RNAs that are crucial in challenging environments, using mechanisms beyond the direct regulation of RNAP activity.

  13. A RADIOIMMUNOASSAY FOR PLACENTAL PROTEIN PP5

    Institute of Scientific and Technical Information of China (English)

    WANGShui-Long; DUGuo-Guang; ZHENGShu-Rong; LIUXin-Jun; YANRen-Ying

    1989-01-01

    A radioimmunoasay of high sendtivity end smbility was developed For placental proteinPP5 (PP5), a syncytiotrophoblast product oF the human placenta. We measured 94 samples from 17 normal nonpregnant women, 47 normal pregnant women, and 30 samples

  14. No horizons in pp-waves

    CERN Document Server

    Hubeny, V E; Hubeny, Veronika E; Rangamani, Mukund

    2002-01-01

    We argue that pp-wave backgrounds can not admit event horizons. We also comment on pp-wave generalizations which would admit horizons and show that there exists a black string solution which asymptotes to a five dimensional plane wave background.

  15. ONKALO pose experiment. Geophysical logging and imaging of drillholes ONK-PP223, ONK-PP226, ONK-PP254 and ONK-PP259...261

    Energy Technology Data Exchange (ETDEWEB)

    Tarvainen, A.-M. (Suomen Malmi Oy, Espoo (Finland))

    2011-08-15

    Suomen Malmi Oy conducted geophysical drillhole logging as well as optical and acoustic imaging of shallow drillholes ONK-PP223, ONK-PP226, ONK-PP254, ONKPP259, ONK-PP260 and ONK-PP261 at ONKALO in the investigation niche ONKTKU- 3 (POSE) between December 2009 and June 2010. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and data processing. The report describes field operation, equipment as well as processing procedures and shows the obtained results and an analysis of their quality in the appendices. The raw and processed data are delivered digitally in WellCAD, PDF and Excel format. (orig.)

  16. Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast

    Institute of Scientific and Technical Information of China (English)

    Dries Castermans; Ils Somers; Johan Kriel; Wendy Louwet; Stefaan Wera; Matthias Versele; Veerle Janssens; Johan M Thevelein

    2012-01-01

    The protein phosphatases PP2A and PP1 are major regulators of a variety of cellular processes in yeast and other eukaryotes.Here,we reveal that both enzymes are direct targets of glucose sensing.Addition of glucose to glucosedeprived yeast cells triggered rapid posttranslational activation of both PP2A and PP1.Glucose activation of PP2A is controlled by regulatory subunits Rts1,Cdc55,Rrd1 and Rrd2.It is associated with rapid carboxymethylation of the catalytic subnnits,which is necessary but not sufficient for activation.Glucose activation of PP1 was fully dependent on regulatory subunits Reg1 and Shp1.Absence of Gac1,GIc8,Reg2 or Red1 partially reduced activation while Pig1 and Pig2 inhibited activation.Full activation of PP2A and PP1 was also dependent on subunits classically considered to belong to the other phosphatase.PP2A activation was dependent on PP1 subunits Reg1 and Shpl while PP1 activation was dependent on PP2A subunit Rts1.Rts1 interacted with both Pph21 and Glc7 under different conditions and these interactions were Regl dependent.Regl-GIc7 interaction is responsible for PP1 involvement in the main glucose repression pathway and we show that deletion of Shpl also causes strong derepression of the invertase gene SUC2.Deletion of the PP2A subunits Pph21 and Pph22,Rrd1 and Rrd2,specifically enhanced the derepression level of SUC2,indicating that PP2A counteracts SUC2 derepression.Interestingly,the effect of the regulatory subunit Rtsl was consistent with its role as a subunit of both PP2A and PP1,affecting derepression and repression of SUC2,respectively.We also show that abolished phosphatase activation,except by reg1A,does not completely block Snf1 dephosphorylation after addition of glucose.Finally,we show that glucose activation of the cAMP-PKA (protein kinase A)pathway is required for glucose activation of both PP2A and PP1.Our results provide novel insight into the complex regulatory role of these two major protein phosphatases in glucose

  17. Analysis of Vernier Scans during the PP2PP run in 2009 (pp at 100 GeV/beam)

    Energy Technology Data Exchange (ETDEWEB)

    Drees, A.

    2011-12-13

    At the end of RHIC's 2009 operation a dedicated run for the PP2PP experiment (part of the STAR experiment) took place from Jun 29 to Jul 06 2009. Polarized protons were accelerated to 100 GeV using ramp-file pp100-90pp2pp with a {beta}* = 22 m in IR6. Since only transverse polarization was required no rotator ramp was in use. The PP2PP experiment consists mainly of two Roman Pot detectors (one horizontal and one vertical) on either side of IR6 in the outgoing-beam arms between the Q3 and Q4 magnets. The yellow pots are in sector 5, the blue ones in sector 6. Roman Pot type detectors are installed inside the beampipe causing an accelerator safety concern. To address this concern there is a limit to the allowable total beam current in the machine while Roman Pots are enabled to move closer to the beam. This limit was set to a motion limit of 5 mm from the center of the beampipe and 50 {center_dot} 10{sup 11} beam current per ring. In order to reduce the background in the detectors, beams were scraped using the RHIC collimator system prior to moving the pots closer. This was typically repeated several times throughout a store since beam halo reforms over the course of hours.

  18. Causal structures of pp-waves

    CERN Document Server

    Hubeny, V E; Hubeny, Veronika E.; Rangamani, Mukund

    2002-01-01

    We discuss the causal structure of pp-wave spacetimes using the ideal point construction outlined by Geroch, Kronheimer, and Penrose. This generalizes the recent work of Marolf and Ross, who considered similar issues for plane wave spacetimes. We address the question regarding the dimension of the causal boundary for certain specific pp-wave backgrounds. In particular, we demonstrate that the pp-wave spacetime which gives rise to the N = 2 sine-Gordon string world-sheet theory is geodesically complete and has a one-dimensional causal boundary.

  19. GridPP returns to CERN

    CERN Multimedia

    Neasan O'Neill

    2011-01-01

    In early September, GridPP, the collaboration that manages the UK’s contribution to the worldwide LHC Computing Grid (wLCG), celebrated a decade of work by holding its twenty-seventh collaboration meeting at CERN.   Officially launched in September 2001, GridPP was one of the original partners in wLCG, funding much of the early work at CERN. Over the last decade GridPP has gone from a mere proposal to almost 30,000 CPUs working for researchers scattered across the globe. Twice a year, GridPP meets to discuss the progress and future plans of the community and this year, for the first time since 2004, decamped to CERN for this biannual meeting on the theme “GridPP in the International Context”. The main meeting was held over 2 days in the IT auditorium and was the perfect opportunity to have contributions from experts based at CERN, alongside those from within GridPP. Opening with a welcome from Frederic Hemmer, Head of the IT Department at CERN, the meeting began with...

  20. Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

    OpenAIRE

    Malouli, Daniel; Hansen, Scott G.; Nakayasu, Ernesto S.; Marshall, Emily E.; Hughes, Colette M.; Ventura, Abigail B.; Gilbride, Roxanne M.; Lewis, Matthew S.; Xu, Guangwu; Kreklywich, Craig; Whizin, Nathan; Fischer, Miranda; Legasse, Alfred W.; Viswanathan, Kasinath; Siess, Don

    2014-01-01

    The most abundantly produced virion protein in human cytomegalovirus (HCMV) is the immunodominant phosphoprotein 65 (pp65), which is frequently included in CMV vaccines. Although it is nonessential for in vitro CMV growth, pp65 displays immunomodulatory functions that support a potential role in primary and/or persistent infection. To determine the contribution of pp65 to CMV infection and immunity, we generated a rhesus CMV lacking both pp65 orthologs (RhCMVΔpp65ab). While ...

  1. Killing tensors in pp-wave spacetimes

    Energy Technology Data Exchange (ETDEWEB)

    Keane, Aidan J [87 Carlton Place, Glasgow G5 9TD, Scotland (United Kingdom); Tupper, Brian O J, E-mail: aidan@countingthoughts.co, E-mail: bt32@rogers.co [Department of Mathematics and Statistics, University of New Brunswick, Fredericton, New Brunswick, E3B 5A3 (Canada)

    2010-12-21

    The formal solution of the second-order Killing tensor equations for the general pp-wave spacetime is given. The Killing tensor equations are integrated fully for some specific pp-wave spacetimes. In particular, the complete solution is given for the conformally flat plane wave spacetimes and we find that irreducible Killing tensors arise for specific classes. The maximum number of independent irreducible Killing tensors admitted by a conformally flat plane wave spacetime is shown to be six. It is shown that every pp-wave spacetime that admits an homothety will admit a Killing tensor of Koutras type and, with the exception of the singular scale-invariant plane wave spacetimes, this Killing tensor is irreducible.

  2. New boundaries for the "ppK-" production in p+p collisions

    Science.gov (United States)

    Epple, Eliane

    2014-11-01

    The HADES collaboration has searched for the anti-kaonic nuclear cluster "ppK-" in p+p collisions by its decay into pΛ. In the course of this analysis several cross checks had to be performed. This report discusses two examples thereof. In one test it was checked whether the presence of background events could introduce a bias on the applied partial wave analysis. The second item discussed here is the extraction of the total pK+Λ production cross section necessary to derive the absolute upper limit on the "ppK-" production cross section.

  3. New boundaries for the “ppK−” production in p+p collisions

    Directory of Open Access Journals (Sweden)

    Epple Eliane

    2014-01-01

    Full Text Available The HADES collaboration has searched for the anti-kaonic nuclear cluster “ppK−” in p+p collisions by its decay into pΛ. In the course of this analysis several cross checks had to be performed. This report discusses two examples thereof. In one test it was checked whether the presence of background events could introduce a bias on the applied partial wave analysis. The second item discussed here is the extraction of the total pK+Λ production cross section necessary to derive the absolute upper limit on the “ppK−” production cross section.

  4. Heavy quark production in pp collisions

    Energy Technology Data Exchange (ETDEWEB)

    McGaughey, P.L. [Los Alamos National Lab., NM (United States); Quack, E. [Gesellschaft fuer Schwerionenforschung, Darmstadt (Germany); Ruuskanen, P.V. [Univ. of Helsinki (Finland)]|[Univ. of Jyvaeskylae (Finland)] [and others

    1995-07-01

    A systematic study of the inclusive single heavy quark and heavy-quark pair production cross sections in pp collisions is presented for RHIC and LHC energies. We compare with existing data when possible. The dependence of the rates on the renormalization and factorization scales is discussed. Predictions of the cross sections are given for two different sets of parton distribution functions.

  5. ISAJET: a Monte Carlo event generator for pp and anti pp interactions. Version 3

    Energy Technology Data Exchange (ETDEWEB)

    Paige, F.E.; Protopopescu, S.D.

    1982-09-01

    ISAJET is a Monte Carlo computer program which simulates pp and anti pp reactions at high energy. It can generate minimum bias events representative of the total inelastic cross section, high PT hadronic events, and Drell-Yan events with a virtual ..gamma.., W/sup + -/, or Z/sup 0/. It is based on perturbative QCD and phenomeno-logical models for jet fragmentation.

  6. Polarization observables for the reaction pp -> pp. pi. /sup 0/ at 800 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Riley, P.J.; Bachman, M.; Hollas, C.L.; McNaughton, K.H.; Xu Shenwu; Bonner, B.E.; Van Dyck, O.B.; McGill, J.; McNaughton, M.W.; Peng, J.C.

    1987-10-22

    The Wolfenstein polarization observables D/sub NN/, D/sub S..cap omega../ and D/sub L..cap omega../, where ..cap omega.. denotes a mixture of S and L polarization components, the induced polarization P, and the analysing power A have been measured for the reaction pp -> pp..pi../sup 0/ at 800, 733, and 647 MeV. Comparisons are made to theoretical predictions of the model of Dubach, Kloet and Silbar.

  7. PP2A: The Wolf in Sheep’s Clothing?

    Energy Technology Data Exchange (ETDEWEB)

    Kiely, Maeve [Department of Life Sciences, and Materials and Surface Science Institute, University of Limerick, Limerick 78666 (Ireland); Kiely, Patrick A., E-mail: Patrick.Kiely@ul.ie [Department of Life Sciences, and Materials and Surface Science Institute, University of Limerick, Limerick 78666 (Ireland); Stokes Institute, University of Limerick 78666, Limerick (Ireland)

    2015-04-13

    Protein Phosphatase 2A (PP2A) is a major serine/threonine phosphatase in cells. It consists of a catalytic subunit (C), a structural subunit (A), and a regulatory/variable B-type subunit. PP2A has a critical role to play in homeostasis where its predominant function is as a phosphatase that regulates the major cell signaling pathways in cells. Changes in the assembly, activity and substrate specificity of the PP2A holoenzyme have a direct role in disease and are a major contributor to the maintenance of the transformed phenotype in cancer. We have learned a lot about how PP2A functions from specific mutations that disrupt the core assembly of PP2A and from viral proteins that target PP2A and inhibit its effect as a phosphatase. This prompted various studies revealing that restoration of PP2A activity benefits some cancer patients. However, our understanding of the mechanism of action of this is limited because of the complex nature of PP2A holoenzyme assembly and because it acts through a wide variety of signaling pathways. Information on PP2A is also conflicting as there are situations whereby inactivation of PP2A induces apoptosis in many cancer cells. In this review we discuss this relationship and we also address many of the pertinent and topical questions that relate to novel therapeutic strategies aimed at altering PP2A activity.

  8. DEVELOPMENT OF THE MODIFIED PP/COPOLYPROPYLENE/POE BLENDS FOR AUTOMOBILE BUMPERS%PP/共聚PP/POE汽车保险杠专用料的研制

    Institute of Scientific and Technical Information of China (English)

    唐忠兴; 苏新

    2003-01-01

    研制了PP/共聚PP/聚烯烃弹性体(POE)汽车保险杠专用料,介绍了POE的结构特点,探讨了POE及共聚PP含量对PP力学等性能的影响.结果表明,POE对PP的增韧优于(乙烯/丙烯/二烯)共聚物(EPDM),共聚PP在PP/共聚PP/POE体系中也起到增韧作用,该共混料可以满足汽车保险杠性能的要求.

  9. pp Interaction in Extended Air Showers

    CERN Document Server

    Kohara, A Kendi; Kodama, Takeshi

    2014-01-01

    Applying the recently constructed analytic representation for the pp scattering amplitudes, we present a study of p-air cross sections, with comparison to the data from Extensive Air Shower (EAS) measurements. The amplitudes describe with precision all available accelerator data at ISR, SPS and LHC energies, and its theoretical basis, together with the very smooth energy dependence of parameters controlled by unitarity and dispersion relations, permit reliable extrapolation to higher energies and to asymptotic ranges. The comparison with cosmic ray data is very satisfactory in the whole pp energy interval from 1 to 100 TeV. High energy asymptotic behaviour of cross sections is investigated in view of the geometric scaling property of the amplitudes. The amplitudes predict that the proton does not behave as a black disk even at asymptotically high enegies, and we discuss possible non-trivial consequences of this fact for pA collision cross sections at higher energies.

  10. pp interactions in extended air showers

    Directory of Open Access Journals (Sweden)

    Kendi Kohara A.

    2015-01-01

    Full Text Available Applying the recently constructed analytic representation for the pp scattering amplitudes, we present a study of p-air cross sections, with comparison to the data from Extensive Air Shower (EAS measurements. The amplitudes describe with precision all available accelerator data at ISR, SPS and LHC energies, and its theoretical basis, together with the very smooth energy dependence of parameters controlled by unitarity and dispersion relations, permit reliable extrapolation to higher energies and to asymptotic ranges. The comparison with cosmic ray data is very satisfactory in the whole pp energy interval from 1 to 100 TeV. High energy asymptotic behaviour of cross sections is investigated in view of the geometric scaling property of the amplitudes. The amplitudes predict that the proton does not behave as a black disk even at asymptotically high enegies, and we discuss possible non-trivial consequences of this fact for pA collision cross sections at higher energies.

  11. PP: A Lisp Pretty Printing System.

    Science.gov (United States)

    1984-12-01

    level :length :lines :array :radix :circle :case : gensym This function is like PRIN1 except that it does not force ,PRINT-ESCAPE, to be T. The...PRINT-CASE, and ,PRINT- GENSYM , respectively. (’llhe last four of these variables are not supported by release 5 of the I isp Machine System...variables. PP:SET-INTERACTIVE-CONTROL-VARIABLES &key :escape :base :pretty :level :length :lines :array :radix :circle :case : gensym This function specifies

  12. Canonical Formulation of pp-waves

    CERN Document Server

    Balasin, Herbert

    2007-01-01

    We construct a Hamiltonian formulation for the class of plane-fronted gravitational waves with parallel rays (pp-waves). Because of the existence of a light-like Killing vector, the dynamics is effectively reduced to a 2+1 evolution with "time" chosen to be light-like. In spite of the vanishing action this allows us to geometrically identify a symplectic form as well as dynamical Hamiltonian, thus casting the system into canonical form.

  13. $pp$-waves in modified gravity

    CERN Document Server

    Baykal, Ahmet

    2015-01-01

    The family of metrics corresponding to the plane-fronted gravitational waves with parallel propagation, commonly referred to as the family of pp-wave metrics, is studied in the context of various modified gravitational models in a self-contained and coherent manner by using a variant of the null coframe formulation of Newman and Penrose and the exterior algebra of differential forms on pseudo-Riemannian manifolds.

  14. b-flavour tagging in pp collisions

    CERN Multimedia

    Birnkraut, Alex

    2015-01-01

    An essential ingredient of all time-dependent CP violation studies of B mesons is the ability to tag the initial flavour of the B meson. The harsh environment of 7 and 8 TeV pp collisions makes this a particularly difficult enterprise. We report progresses in the flavour tagging of B0 and Bs mesons, including developments of novel techniques like the use of an opposite side charm tagger.

  15. String Theory on Parallelizable PP-Waves

    Energy Technology Data Exchange (ETDEWEB)

    Sadri, Darius J

    2003-05-05

    The most general parallelizable pp-wave backgrounds which are non-dilatonic solutions in the NS-NS sector of type IIA and IIB string theories are considered. We demonstrate that parallelizable pp-wave backgrounds are necessarily homogeneous plane-waves, and that a large class of homogeneous plane-waves are parallelizable, stating the necessary conditions. Such plane-waves can be classified according to the number of preserved supersymmetries. In type IIA, these include backgrounds preserving 16, 18, 20, 22 and 24 supercharges, while in the IIB case they preserve 16, 20, 24 or 28 supercharges. An intriguing property of parallelizable pp-wave backgrounds is that the bosonic part of these solutions are invariant under T-duality, while the number of supercharges might change under T-duality. Due to their {alpha}{prime} exactness, they provide interesting backgrounds for studying string theory. Quantization of string modes, their compactification and behavior under T-duality are studied. In addition, we consider BPS Dp-branes, and show that these Dp-branes can be classified in terms of the locations of their world volumes with respect to the background H-field.

  16. String Theory on Parallelizable PP-waves

    CERN Document Server

    Sadri, D; Sadri, Darius; Sheikh-Jabbari, Mohammad M.

    2003-01-01

    The most general parallelizable pp-wave backgrounds which are non-dilatonic solutions in the NS-NS sector of type IIA and IIB string theories are considered. We demonstrate that parallelizable pp-wave backgrounds are necessarily homogeneous plane-waves, and that a large class of homogeneous plane-waves are parallelizable, stating the necessary conditions. Such plane-waves can be classified according to the number of preserved supersymmetries. In type IIA, these include backgrounds preserving 16, 18, 20, 22 and 24 supercharges, while in the IIB case they preserve 16, 20, 24 or 28 supercharges. An intriguing property of parallelizable pp-wave backgrounds is that the bosonic part of these solutions are invariant under T-duality, while the number of supercharges might change under T-duality. Due to their $\\alpha^\\prime$ exactness, they provide interesting backgrounds for studying string theory. Quantization of string modes, their compactification and behaviour under T-duality are studied. In addition, we consider...

  17. Characterization of the morphology of iPP/sPP blends with various compositions

    Directory of Open Access Journals (Sweden)

    S. Bourbigot

    2013-03-01

    Full Text Available The paper investigates the morphology and the structural properties of blends of isotactic polypropylene (iPP and syndiotactic polypropylene (sPP having different compositions using different techniques. Solid-state nuclear magnetic resonance (NMR permits via appropriate sequence to measure the composition, conformation and dynamics, and intimacy of mixing of polymeric materials. Measurement of relaxation times gives information on local structure of phases with different mobility. The morphology is directly related to the structural organization of the blends. The crystallization rate decreases as a function of the sPP content. The minor component is dispersed as a nodule in the main component of the blend and it plays the role of nucleating agent on it. Besides, morphology changes occur for the composition 50/50 (wt/wt of the blend iPP/sPP. Different phases are identified, namely free amorphous, constrained amorphous and crystalline regions which exhibit different molecular mobilities. It is also shown at the interphase matrix-nodules, the nodules create a constrained amorphous zone.

  18. Cytomegalovirus pp65 limits dissemination but is dispensable for persistence

    Energy Technology Data Exchange (ETDEWEB)

    Malouli, Daniel; Hansen, Scott G.; Nakayasu, Ernesto S.; Marshall, Emily E.; Hughes, Colette M.; Ventura, Abigail B.; Gilbride, Roxanne M.; Lewis, Matthew S.; Xu, Guangwu; Kreklywich, Craig; Whizin, Nathan; Fischer, Miranda; Legasse, Alfred W.; Viswanathan, Kasinath; Siess, Don; Camp, David G.; Axthelm, Michael K.; Kahl, Christoph; DeFilippis, Victor R.; Smith, Richard D.; Streblow, Daniel N.; Picker, Louis J.; Früh, Klaus

    2014-04-01

    The tegument phosphoprotein pp65 (UL83) is the most abundant virion protein in human cytomegalovirus (HCMV). Since pp65 is immunodominant in persistently infected individuals, subunit vaccines against HCMV often include pp65 as T cell stimulatory component. Although HCMV pp65 is non-essential for viral growth in vitro it is thought to have an important role in primary and persistent infection since pp65 displays multiple immunomodulatory functions. To determine whether pp65 is required for infection and to evaluate its role in natural and vaccination-induced immunity we generated a rhesus CMV lacking both homologues, pp65a (Rh111) and pp65b (Rh112). Lack of pp65 resulted in a slight growth defect in vitro and an increase of defective particle formation. However, most pp65-deleted virions in the supernatant were phenotypically normal and proteomics analysis revealed that the ratios of the remaining viral proteins were largely unchanged. RhCMV Δpp65ab was able to persistently infect CMV-negative rhesus macaques (RM) and to super-infect RM previously infected with CMV. To determine whether T cells against pp65 are essential for protection against CMV, we challenged Δpp65ab-infected animals with RhCMV ΔUS2-11, a viral recombinant that lacks inhibitors of MHC-I antigen presentation and is thus unable to overcome CMV-specific T cell immunity. Despite a complete lack of pp65-specific T cells, Δpp65ab protected against ΔUS2-11 challenge suggesting that pp65-specific T cells are not essential for T cell immunity against CMV. Using the same approach we further demonstrate that pp65b-specific T cells, induced by heterologous prime/boost vaccination, are not sufficient to protect against ΔUS2-11 challenge. Our data provides a new approach to test the efficacy of subunit vaccine candidates and suggest that pp65 vaccines are insufficient to induce a T cell response that recapitulates the protective effect of natural infection.

  19. Studies on the properties of rice-husk-filled-PP composites: effect of maleated PP

    Directory of Open Access Journals (Sweden)

    Simone Maria Leal Rosa

    2009-09-01

    Full Text Available Rice husk is a by-product of rice milling process that usually finds inadequate final disposal (burning, land filling. Thermoplastics composites filled with rice husk flour are materials that offer an alternative for using this agricultural resource viewing the production of low dense materials with some specific properties. In this work composites of polypropylene (PP and rice husk flour (RHF were prepared by melt extrusion. Maleic anhydride-modified PP (MAPP was added as a coupling agent. It was verified that tensile strength decreased with filler loading. The presence of MAPP improved this property showing a strong dependence on the MAPP/RHF ratio (MAPP/RHF = 0.03 produced the best results. The density of the composites slightly increased with filler and coupling agent in comparison to pure PP. The presence of MAPP diminished more than 20% water uptake in highly-loaded composites.

  20. Isothermal Crystallization Kinetics of Dynamically Cured PP/MAH-g-PP/Epoxy Blends%动态固化PP/MAH-g-PP/EP共混物的等温结晶动力学

    Institute of Scientific and Technical Information of China (English)

    江学良; 张隐西

    2009-01-01

    分别用Avrami方程和Hoffman结晶理论研究了马来酸酐接枝聚丙烯(MAH-g-PP)增容的动态固化聚丙烯(PP)/环氧树脂(EP)共混物中PP等温结晶动力学.实验结果表明,动态固化PP/MAH-g-PP/EP共混物中环氧颗粒可作为PP的成核剂,能显著促进PP的结晶.根据Avrami方程,动态固化PP/MAH-g-PP/EP共混物中PP的结晶速率常数K(T) 明显大于纯PP的K(T).依据Hoffman理论研究动态固化PP/MAH-g-PP/EP共混物结晶热动力学,动态固化PP/MAH-g-PP/EP共混物折叠链表面自由能(σe)明显小于PP折叠链表面自由能(σe).

  1. Nuclear Slope Parameter Of pp and (-p)p Elastic Scattering in QCD Inspired Model

    Institute of Scientific and Technical Information of China (English)

    MA Shan-Jun; LU Juan; LU Hai-Liang; MA Wei-Xing; FAN Hong-Yi; HE Xiao-Rong

    2008-01-01

    Based on the quaxk-gluon structure of nucleon and the possible existence of Odderon in strong interaction process due to gluon self-interaction, the elastic scatterings of pp and pp at high energies axe studied. The contributions from individual terms of quark-quark, gluon-gluon interactions, quaxk-gluon interference, and the Odderon terms to the nuclear slope parameter B(s) are analyzed. Our results show that the QCD inspired model gives a good fit to the LHC experimental data of the nucleax slope parameter.

  2. PP-O and PP-V, Monascus pigment homologues, production, and phylogenetic analysis in Penicillium purpurogenum.

    Science.gov (United States)

    Arai, Teppei; Kojima, Ryo; Motegi, Yoshiki; Kato, Jun; Kasumi, Takafumi; Ogihara, Jun

    2015-12-01

    The production of pigments as secondary metabolites by microbes is known to vary by species and by physiological conditions within a single strain. The fungus strain Penicillium purpurogenum IAM15392 has been found to produce violet pigment (PP-V) and orange pigment (PP-O),Monascus azaphilone pigment homologues, when grown under specific culture conditions. In this study, we analysed PP-V and PP-O production capability in seven strains of P. purpurogenum in addition to strain IAM15392 under specific culture conditions. The pigment production pattern of five strains cultivated in PP-V production medium was similar to that of strain IAM15392, and all violet pigments produced by these five strains were confirmed to be PP-V. Strains that did not produce pigment were also identified. In addition, two strains cultivated in PP-O production medium produced a violet pigment identified as PP-V. The ribosomal DNA (rDNA) internal transcribed spacer (ITS) region sequences from the eight P. purpurogenum strains were sequenced and used to construct a neighbor-joining phylogenetic tree. PP-O and PP-V production of P. purpurogenum was shown to be related to phylogenetic placement based on rDNA ITS sequence. Based on these results, two hypotheses for the alteration of pigment production of P. purpurogenum in evolution were proposed.

  3. Modifikacija PP/SAN mešanic:

    OpenAIRE

    Musil, Vojko; Radonjič, Gregor

    1995-01-01

    Properties of isotactic polypropylene (PP) can be improved with the preparation of PP blends. Polymer blend PP/SAN is immiscible and it shows a decrease in some mechanical properties but processing and some other properties can be improved. Addition of an impact modifier can also change the final properties of the PP/SAN blends. As a modifier we used poly (styrene-b-ethylene-co-butylene-b-styrene) (SEBS) triblock copolymer. Blends were prepared in the melt in a Brabender kneading chamber, coo...

  4. Modifikacija PP/SAN mešanic

    OpenAIRE

    Radonjič, Gregor; Musil, Vojko

    2015-01-01

    Izotaktični polipropilen (PP) je med poliolefini eden od najpogosteje uporabljanih polimerov. Kopolimer stiren/akrilonitril ima nekatere dobre lastnosti , ki skupaj z lastnostmi PP omogočajo doseganje sinergističnih učinkov. Polimerna mešanica PP/SAN je nemešljiva in kaže določeno poslabšanje nekaterih mehanskih lastnosti, vendar pa se izboljšajo predelovalne in nekatere druge lastnosti. Na spremembe lastnosti PP/SAN mešanic lahko vplivamo tudi z dodatkom modifikatorja. Zaradi omenjenih dejst...

  5. Displacement affinity chromatography of protein phosphatase one (PP1 complexes

    Directory of Open Access Journals (Sweden)

    Gourlay Robert

    2008-11-01

    Full Text Available Abstract Background Protein phosphatase one (PP1 is a ubiquitously expressed, highly conserved protein phosphatase that dephosphorylates target protein serine and threonine residues. PP1 is localized to its site of action by interacting with targeting or regulatory proteins, a majority of which contains a primary docking site referred to as the RVXF/W motif. Results We demonstrate that a peptide based on the RVXF/W motif can effectively displace PP1 bound proteins from PP1 retained on the phosphatase affinity matrix microcystin-Sepharose. Subsequent co-immunoprecipitation experiments confirmed that each identified binding protein was either a direct PP1 interactor or was in a complex that contains PP1. Our results have linked PP1 to numerous new nuclear functions and proteins, including Ki-67, Rif-1, topoisomerase IIα, several nuclear helicases, NUP153 and the TRRAP complex. Conclusion This modification of the microcystin-Sepharose technique offers an effective means of purifying novel PP1 regulatory subunits and associated proteins and provides a simple method to uncover a link between PP1 and additional cellular processes.

  6. The electroweak corrections to the process pp(γγ→(tt))pp at the LHC%LHC对撞机上(pp)(γγ→ tt)(pp)过程的电弱修正

    Institute of Scientific and Technical Information of China (English)

    孙衍斌; 刘娜; 胡浩月; 张健; 田佳佳

    2011-01-01

    In this paper the electroweak corrections to the process pp (rr→tt)pp at the LHC are calculated in the equivalent photon approximation. Our results shows that the corrected cross sections for the process pp(rr→tt)pp at the LHC are small relatively to its subprocess (rr→t t), but the electroweak correction effect is large up to -7%. Therefore, for the process pp(rr→tt)pp which has very clean environment, its electroweak corrections have to be included.%在等效光子近似下计算了LHC对撞机上pp(γγ→(tt))pp过程的电弱修正.结果表明:pp(γγ→(tt))pp过程修正后的截面相对较小,但电弱修正效应却高达到-7%左右.所以,对于LHC对撞机上背景非常干净的pp(γγ→(tt))pp过程而育,电弱修正效应是不能忽略的.

  7. Study of baryon and search for dibaryon resonances by the pp{yields}pp{pi}{sup +}{pi}{sup -} reaction

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, E.; Bashkanov, M.; Brodowski, W.; Bilger, R.; Clement, H.; Meier, R. [Physikalisches Institut der Universitaet Tuebingen, Morgenstelle 14, D-72076, Tuebingen (Germany); Calen, H.; Ekstroem, C.; Kupsc, A. [Svedberg Laboratory, S-751 21, Uppsala (Sweden); Fransson, K.; Haeggstroem, S.; Hoeistad, B.; Johanson, J.; Johansson, A.; Johansson, T.; Kullander, S.; Marciniewski, P. [Department of Radiation Sciences, Uppsala University (Sweden); Greiff, J. [I. Institut fuer Experimentalphysik der Universitaet Hamburg, D-22761, Hamburg (Germany); Kilian, K. [IKP - Forschungszentrum Juelich GmbH, D-52425, Juelich (Germany); Morosov, B. [Joint Institute for Nuclear Research Dubna, 101000, Moscow (Russian Federation); Oelert, W.; Paetzold, J.; Ruber, R.J.M.Y.; Scobel, W.; Stepaniak, J.; Sukhanov, A.; Turowiecki, A.; Wagner, G.J.; Wilhelmi, Z.; Zabierowski, J.; Zlomanczuk, J.

    2003-11-01

    Exclusive measurements of the two-pion production channel pp{yields}pp{pi} + {pi}{sup -} have been carried out near threshold at CELSIUS with the PROMICE/WASA detector. They reveal pp{yields}pp{sup *}(1440){yields}pp{sigma}{yields}pp({pi}{sup +}{pi}{sup -}){sub I=l=0} as the dominant process at these energies, however, the data exhibit also significant contributions from p{sup *}(1440){yields}{delta}{pi}{yields}p({pi}{sup +}{pi}{sup -}){sub I=l=0}. From the observed interference of these Roper decay routes their relative branching ratio is derived. The status on the search for NN-decoupled NN{pi}-resonances is reviewed with regard to recent experimental searches in the pionic double charge exchange in nuclei, the two-pion production in nucleon-nucleon collisions, the photo pion-production on the deuteron and the electro pion-production in nuclei. (orig.)

  8. Damping of forward neutrons in pp collisions

    Science.gov (United States)

    Kopeliovich, B. Z.; Potashnikova, I. K.; Schmidt, Ivan; Soffer, J.

    2008-07-01

    We calculate absorptive corrections to single pion exchange in the production of leading neutrons in pp collisions. Contrary to the usual procedure of convolving the survival probability with the cross section, we apply corrections to the spin amplitudes. The nonflip amplitude turns out to be much more suppressed by absorption than the spin-flip one. We identify the projectile proton Fock state responsible for the absorptive corrections as a color octet-octet 5-quarks configuration. Calculations within two very different models, color-dipole light-cone description, and in hadronic representation, lead to rather similar absorptive corrections. We found a much stronger damping of leading neutrons than in some of previous estimates. Correspondingly, the cross section is considerably smaller than was measured at ISR. However, comparison with recent measurements by the ZEUS collaboration of neutron production in deep-inelastic scattering provides a strong motivation for challenging the normalization of the ISR data. This conjecture is also supported by preliminary data from the NA49 experiment for neutron production in pp collisions at SPS.

  9. Strangeness production in AA and pp collisions

    Energy Technology Data Exchange (ETDEWEB)

    Castorina, Paolo [Universita di Catania, Dipartimento di Fisica ed Astronomia, Catania (Italy); INFN, Catania (Italy); Satz, Helmut [Universitaet Bielefeld, Fakultaet fuer Physik, Bielefeld (Germany)

    2016-07-15

    Boost-invariant hadron production in high-energy collisions occurs in causally disconnected regions of finite space-time size. As a result, globally conserved quantum numbers (charge, strangeness, baryon number) are conserved locally in spatially restricted correlation clusters. Their size is determined by two time scales: the equilibration time specifying the formation of a quark-gluon plasma, and the hadronization time, specifying the onset of confinement. The expected values for these scales provide the theoretical basis for the suppression observed for strangeness production in elementary interactions (pp, e{sup +}e{sup -}) below LHC energies. In contrast, the space-time superposition of individual collisions in high-energy heavy-ion interactions leads to higher energy densities, resulting in much later hadronization and hence much larger hadronization volumes. This largely removes the causality constraints and results in an ideal hadronic resonance gas in full chemical equilibrium. In the present paper, we determine the collision energies needed for that; we also estimate when pp collisions reach comparable hadronization volumes and thus determine when strangeness suppression should disappear there as well. (orig.)

  10. Strangeness production in AA and pp collisions

    Science.gov (United States)

    Castorina, Paolo; Satz, Helmut

    2016-07-01

    Boost-invariant hadron production in high-energy collisions occurs in causally disconnected regions of finite space-time size. As a result, globally conserved quantum numbers (charge, strangeness, baryon number) are conserved locally in spatially restricted correlation clusters. Their size is determined by two time scales: the equilibration time specifying the formation of a quark-gluon plasma, and the hadronization time, specifying the onset of confinement. The expected values for these scales provide the theoretical basis for the suppression observed for strangeness production in elementary interactions ( pp , e^+e^- below LHC energies. In contrast, the space-time superposition of individual collisions in high-energy heavy-ion interactions leads to higher energy densities, resulting in much later hadronization and hence much larger hadronization volumes. This largely removes the causality constraints and results in an ideal hadronic resonance gas in full chemical equilibrium. In the present paper, we determine the collision energies needed for that; we also estimate when pp collisions reach comparable hadronization volumes and thus determine when strangeness suppression should disappear there as well.

  11. Structural basis for transcription regulation by alarmone ppGpp.

    Science.gov (United States)

    Artsimovitch, Irina; Patlan, Vsevolod; Sekine, Shun-ichi; Vassylyeva, Marina N; Hosaka, Takeshi; Ochi, Kozo; Yokoyama, Shigeyuki; Vassylyev, Dmitry G

    2004-04-30

    Guanosine-tetraphosphate (ppGpp) is a major regulator of stringent control, an adaptive response of bacteria to amino acid starvation. The 2.7 A resolution structure of the Thermus thermophilus RNA polymerase (RNAP) holoenzyme in complex with ppGpp reveals that ppGpp binds to the same site near the active center in both independent RNAP molecules in the crystal but in strikingly distinct orientations. Binding is symmetrical with respect to the two diphosphates of ppGpp and is relaxed with respect to the orientation of the nucleotide base. Different modes of ppGpp binding are coupled with asymmetry of the active site configurations. The results suggest that base pairing of ppGpp with cytosines in the nontemplate DNA strand might be an essential component of transcription control by ppGpp. We present experimental evidence highlighting the importance of base-specific contacts between ppGpp and specific cytosine residues during both transcription initiation and elongation.

  12. Rapidity dependence of particle densities in pp and AA collisions

    CERN Document Server

    Bautista, Irais; Milhano, Jose Guilherme; Dias de Deus, Jorge

    2012-01-01

    We use multiple scattering and energy conservation arguments to describe $dn/d\\eta_{NANA}$ as a function of $dn/d\\eta_{pp}$ in the framework of string percolation. We discuss the pseudo-rapidity $\\eta$? and beam rapidity Y dependence of particle densities. We present our results for pp, Au- Au, and Pb-Pb collisions at RHIC and LHC.

  13. Noether gauge symmetry classes for pp-wave spacetimes

    CERN Document Server

    Camci, U

    2016-01-01

    The Noether gauge symmetries of geodesic Lagrangian for the pp-wave spacetimes are determined in each of the Noether gauge symmetry classes of the pp-wave spacetimes. It is shown that a type N pp-wave spacetime can admit at most three Noether gauge symmetry, and furthermore the number of Noether gauge symmetries turn out to be four, five, six, seven and eight. We found that all conformally flat plane wave spacetimes admit the maximal, i.e. ten, Noether gauge symmetry. Also it is found that if the pp-wave spacetime is non-conformally flat plane wave, then the number of Noether gauge symmetry is nine or ten. By means of the obtained Noether constants the search of the exact solutions of the geodesic equations for the pp-wave spacetimes is considered and we found new exact solutions of the geodesic equations in some special Noether gauge symmetry classes.

  14. /bar p/p collider physics

    Energy Technology Data Exchange (ETDEWEB)

    Green, D.

    1989-03-01

    This note encompasses a set of six lectures given at the summer school held at Campos Do Jordao in January of 1989 near Sao Paulo, Brazil. The intent of the lectures was to describe the physics of /bar p/p at CERN and Fermilab. Particular attention has been paid to making a self contained presentation to a prospective audience of graduate students. Since large Monte Carlo codes might not be available to all members of this audience, great reliance was placed on ''back of the envelope estimates.'' Emphasis was also placed on experimental data rather than theoretical speculation, since predictions for, for example, supersymmetric particle production are easily obtained by transcription of formulae already obtained. 9 refs., 67 figs., 2 tabs.

  15. Strangeness Production in AA and pp Collisions

    CERN Document Server

    Satz, P Castorina ad H

    2016-01-01

    Boost-invariant hadron production in high energy collisions occurs in causally disconnected regions of finite space-time size. As a result, globally conserved quantum numbers (charge, strangeness, baryon number) are conserved locally in spatially restricted correlation clusters. Their size is determined by two time scales: the equilibration time specifying the formation of a quark-gluon plasma, and the hadronization time, specifying the onset of confinement. The expected values for these scales provide the theoretical basis for the suppression observed for strangeness production in elementary interactions ($pp$, $e^+e^-$) below LHC energies. In contrast, the space-time superposition of individual collisions in high energy heavy ion interactions leads to higher energy densities, resulting in much later hadronization and hence much larger hadronization volumes. This largely removes the causality constraints and results in an ideal hadronic resonance gas in full chemical equilibrium. In the present paper, we det...

  16. PR65A phosphorylation regulates PP2A complex signaling.

    Directory of Open Access Journals (Sweden)

    Kumar Kotlo

    Full Text Available Serine-threonine Protein phosphatase 2 A (PP2A, a member of the PPP family of phosphatases, regulates a variety of essential cellular processes, including cell-cycling, DNA replication, transcription, translation, and secondary signaling pathways. In the heart, increased PP2A activity/signaling has been linked to cardiac remodeling, contractile dysfunction and, in failure, arrythmogenicity. The core PP2A complex is a hetero-trimeric holoenzyme consisting of a 36 kDa catalytic subunit (PP2Ac; a regulatory scaffold subunit of 65 kDa (PR65A or PP2Aa; and one of at least 18 associated variable regulatory proteins (B subunits classified into 3 families. In the present study, three in vivo sites of phosphorylation in cardiac PR65A are identified (S303, T268, S314. Using HEK cells transfected with recombinant forms of PR65A with phosphomimetic (P-PR65A and non-phosphorylated (N-PR65A amino acid substitutions at these sites, these phosphorylations were shown to inhibit the interaction of PR65A with PP2Ac and PP2A holoenzyme signaling. Forty-seven phospho-proteins were increased in abundance in HEK cells transfected with P-PR65A versus N-PR65A by phospho-protein profiling using 2D-DIGE analysis on phospho-enriched whole cell protein extracts. Among these proteins were elongation factor 1α (EF1A, elongation factor 2, heat shock protein 60 (HSP60, NADPH-dehydrogenase 1 alpha sub complex, annexin A, and PR65A. Compared to controls, failing hearts from the Dahl rat had less phosphorylated PR65A protein abundance and increased PP2A activity. Thus, PR65A phosphorylation is an in vivo mechanism for regulation of the PP2A signaling complex and increased PP2A activity in heart failure.

  17. Electron spin resonance studies on PS, PP and PS/PP blends under gamma irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Reyes, Jacobo E-mail: reyesj@camelot.rect.ucv.ve; Albano, Carmen E-mail: calbano@ivic.vealbanoc@camelot.rect.ucv.ve; Claro, Marjorie; Moronta, Delfin

    2003-06-01

    Electron spin resonance studies on polystyrene (PS), polypropylene (PP) and on 80/20 PS/PP blends with and without compatibilizer (block SBS), at 7.5 wt%, irradiated with gamma rays from a {sup 60}Co source at a dose rate of 4.8 kGy/h and at integral irradiation doses of 10, 25, 50, 60, 70, 400, 800 and 1300 kGy in the presence of air and at room temperature are reported. Dependence of resonance line width, Hpp, resonance line shapes, K, and resonance line intensity, Ipp, on the integral dose of irradiation is investigated. Nature of free radicals after 10 days of air storage is discussed.

  18. Study on 'soft' and 'hard' interactions in (-p)p (pp) collisions using HIJING and PYTHIA

    Institute of Scientific and Technical Information of China (English)

    Zhang Yi-Fei; Huang Sheng-Li; Zhang Zi-Ping; Wu Jian

    2007-01-01

    This paper presents a study on 'hard' and 'soft' interactions in (-p)p (pp) collisions using a phenomenological model of HIJING, the jet-cone reconstruction method is employed to select the 'hard' and 'soft' event sub-samples from minimum bias events. It is found that the HIJING model can reproduce the energy scaling behaviour of mean transverse momentum (〈pT〉) distributions of charged hadrons versus multiplicity (Nch) in 'soft' events. From the PYTHIA simulation comparing with the HIJING model, the enhancement of the kaon and proton yields from 'hard'interactions comparing with 'soft' interactions is observed to be due to the mini-jets effect. These mechanisms responsible for the increase of charged hadron's 〈pT〉 are different in 'soft' and 'hard' interactions.

  19. Chiral Perturbation Theory and the $pp \\to pp \\pi^0$ Reaction Near Threshold

    CERN Document Server

    Sato, T; Myhrer, F; Kubodera, K

    1997-01-01

    A chiral-perturbative consideration of the near-threshold pp -> pp pi0 reaction indicates that the pion-rescattering term has a substantial energy and momentum dependence. The existing calculations that incorporate this dependence give pion rescattering contributions significantly larger than those of the conventional treatment, and this enhanced rescattering term interferes destructively with the one-body impulse term, leading to theoretical cross sections that are much smaller than the observed values. However, since the existing calculations are based on coordinate-space representation, they involve a number of simplifying assumptions about the energy-momentum flow in the rescattering diagram, even though the delicate interplay between the one-body and two-body terms makes it desirable to avoid these kinematical assumptions. We carry out here a momentum-space calculation that retains the energy-momentum dependence of the vertices as predicted by chiral perturbation theory. Our improved treatment increases ...

  20. Interrelationships of morphology, thermal and mechanical properties in uncrosslinked and dynamically crosslinked PP/EOC and PP/EPDM blends

    Directory of Open Access Journals (Sweden)

    2010-04-01

    Full Text Available Thermoplastic vulcanizates (TPVs based on polypropylene (PP with ethylene octene copolymer (EOC and ethylene propylene diene rubber (EPDM have been developed by coagent assisted dicumyl peroxide crosslinking system. The study was pursued to explore the influence of two dissimilar polyolefin polymers (EOC and EPDM having different molecular architectures on the state and mode of dispersion of the blend components and their effects with special reference to morphological, thermal and mechanical characteristics. The effects of dynamic crosslinking of the PP/EOC and PP/EPDM have been compared by varying the concentration of crosslinking agent and ratio of blend components. The results suggested that the uncrosslinked and dynamically crosslinked blends of PP/EOC exhibit superior mechanical properties over PP/EPDM blends. From the hystersis experiments it was found that PP/EOC blends also perform better fatigue properties over PP/EPDM based blends. It was demonstrated that, the origin of the improved mechanical properties of EOC based blends is due to the combined effect of the unique molecular architecture with the presence of smaller crystals and better interfacial interaction of EOC phase with PP as supported by the results of thermal and fatigue analyses.

  1. The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in oocyte meiosis II.

    Science.gov (United States)

    Chambon, Jean-Philippe; Touati, Sandra A; Berneau, Stéphane; Cladière, Damien; Hebras, Céline; Groeme, Rachel; McDougall, Alex; Wassmann, Katja

    2013-03-18

    Haploid gametes are generated through two consecutive meiotic divisions, with the segregation of chromosome pairs in meiosis I and sister chromatids in meiosis II. Separase-mediated stepwise removal of cohesion, first from chromosome arms and later from the centromere region, is a prerequisite for maintaining sister chromatids together until their separation in meiosis II [1]. In all model organisms, centromeric cohesin is protected from separase-dependent removal in meiosis I through the activity of PP2A-B56 phosphatase, which is recruited to centromeres by shugoshin/MEI-S332 (Sgo) [2-5]. How this protection of centromeric cohesin is removed in meiosis II is not entirely clear; we find that all the PP2A subunits remain colocalized with the cohesin subunit Rec8 at the centromere of metaphase II chromosomes. Here, we show that sister chromatid separation in oocytes depends on a PP2A inhibitor, namely I2PP2A. I2PP2A colocalizes with the PP2A enzyme at centromeres at metaphase II, independently of bipolar attachment. When I2PP2A is depleted, sister chromatids fail to segregate during meiosis II. Our findings demonstrate that in oocytes I2PP2A is essential for faithful sister chromatid segregation by mediating deprotection of centromeric cohesin in meiosis II. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Abaca fibre reinforced PP composites and comparison with jute and flax fibre PP composites

    Directory of Open Access Journals (Sweden)

    2007-11-01

    Full Text Available Abaca fibre reinforced PP composites were fabricated with different fibre loadings (20, 30, 40, 50wt% and in some cases 35 and 45 wt%. Flax and jute fibre reinforced PP composites were also fabricated with 30 wt% fibre loading. The mechanical properties, odour emission and structure properties were investigated for those composites. Tensile, flexural and Charpy impact strengths were found to increase for fibre loadings up to 40 wt% and then decreased. Falling weight impact tests were also carried out and the same tendency was observed. Owing to the addition of coupling agent (maleated polypropylene -MAH-PP, the tensile, flexural and falling weight impact properties were found to increase in between 30 to 80% for different fibre loadings. When comparing jute and flax fibre composites with abaca fibre composites, jute fibre composites provided best tensile properties but abaca fibre polypropylene composites were shown to provide best notch Charpy and falling weight impact properties. Odours released by flax fibre composites were smaller than jute and abaca fibre composites.

  3. (p)ppGpp and the bacterial cell cycle

    Indian Academy of Sciences (India)

    Aanisa Nazir; Rajendran Harinarayanan

    2016-06-01

    Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent response) and elicit appropriate adaptive responses mainly through the regulation of transcription. Although at different concentrations (p)ppGpp affect the expression of distinct set of genes, the two well-characterized responses are reduction in expression of the protein synthesis machinery and increase in the expression of genes coding for amino acid biosynthesis. In Escherichia coli, the cellular (p)ppGpp level inversely correlates with the growth rate and increasing its concentration decreases the steady state growth rate in a defined growth medium. Since change in growth rate must be accompanied by changes in cell cycle parameters set through the activities of the DNA replication and cell division apparatus, (p)ppGpp could coordinate protein synthesis (cell mass increase) with these processes. Here we review the role of (p)ppGpp in bacterial cell cycle regulation.

  4. ALA-induced PpIX fluorescence in epileptogenic tissue

    Science.gov (United States)

    Kleen, Jonathan K.; Valdes, Pablo A.; Harris, Brent T.; Holmes, Gregory L.; Paulsen, Keith D.; Roberts, David W.

    2011-03-01

    Astrogliotic tissue displays markedly increased levels of ALA-induced PpIX fluorescence, making it useful for fluorescence-guided resection in glioma surgery. In patients with temporal lobe epilepsy (TLE) and corresponding animal models, there are areas of astrogliosis that often co-localize with the epileptic focus, which can be resected to eliminate seizures in the majority of treated patients. If this epileptogenic tissue can exhibit PpIX fluorescence that is sufficiently localized, it could potentially help identify margins in epilepsy surgery. We tested the hypothesis that ALA-induced PpIX fluorescence could visually accentuate epileptogenic tissue, using an established animal model of chronic TLE. An acute dose of pilocarpine was used to induce chronic seizure activity in a rat. This rat and a normal control were given ALA, euthanized, and brains examined post-mortem for PpIX fluorescence and neuropathology. Preliminary evidence indicates increased PpIX fluorescence in areas associated with chronic epileptic changes and seizure generation in TLE, including the hippocampus and parahippocampal areas. In addition, strong PpIX fluorescence was clearly observed in layer II of the piriform cortex, a region known for epileptic reorganization and involvement in the generation of seizures in animal studies. We are further investigating whether ALA-induced PpIX fluorescence can consistently identify epileptogenic zones, which could warrant the extension of this technique to clinical studies for use as an adjuvant guidance technology in the resection of epileptic tissue.

  5. The magic dance of the alarmones (p)ppGpp.

    Science.gov (United States)

    Steinchen, Wieland; Bange, Gert

    2016-08-01

    The alarmones (p)ppGpp are important second messengers that orchestrate pleiotropic adaptations of bacteria and plant chloroplasts in response to starvation and stress. Here, we review our structural and mechanistic knowledge on (p)ppGpp metabolism including their synthesis, degradation and interconversion by a highly diverse set of enzymes. Increasing structural information shows how (p)ppGpp interacts with an incredibly diverse set of different targets that are essential for replication, transcription, translation, ribosome assembly and metabolism. This raises the question how the chemically rather simple (p)ppGpp is able to interact with these different targets? Structural analysis shows that the diversity of (p)ppGpp interaction with cellular targets critically relies on the conformational flexibility of the 3' and 5' phosphate moieties allowing alarmones to efficiently modulate the activity of target structures in a broad concentration range. Current approaches in the design of (p)ppGpp-analogs as future antibiotics might be aided by the comprehension of conformational flexibility exhibited by the magic dancers (p)ppGpp.

  6. (p)ppGpp and the bacterial cell cycle.

    Science.gov (United States)

    Nazir, Aanisa; Harinarayanan, Rajendran

    2016-06-01

    Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent response) and elicit appropriate adaptive responses mainly through the regulation of transcription. Although at different concentrations (p)ppGpp affect the expression of distinct set of genes, the two well-characterized responses are reduction in expression of the protein synthesis machinery and increase in the expression of genes coding for amino acid biosynthesis. In Escherichia coli, the cellular (p)ppGpp level inversely correlates with the growth rate and increasing its concentration decreases the steady state growth rate in a defined growth medium. Since change in growth rate must be accompanied by changes in cell cycle parameters set through the activities of the DNA replication and cell division apparatus, (p)ppGpp could coordinate protein synthesis (cell mass increase) with these processes. Here we review the role of (p)ppGpp in bacterial cell cycle regulation.

  7. Some nonlinear parameters of PP intervals of pulse main peaks

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The PP intervals of pulse main peaks from healthy and unhealthy people (arrhythmia) have different nonlinear characteristics. In this paper, the extraction of PP intervals of pulse main peaks is achieved by picking up P peaks of pulse wave with wavelet transform. Furthermore, several nonlinear parameters (correlative dimensions, maximum Lyapunov exponents, complexity and approximate entropy) of the PP intervals of pulse main peaks extracted from normal and unhealthy pulse signals are calculated, with the results showing that these nonlinear parameters calculated from the main wave interval signals are helpful for analyzing human's health state and diagnosing heart diseases.

  8. EMODnet Physical Parameters (EMODNet PP) Portal

    Science.gov (United States)

    Novellino, A.; Schaap, D.; Manzella, G. M. R.; Pouliquen, S.; Gorringe, P.

    2012-04-01

    In December 2007 the European Parliament and Council adopted a common text for the Marine Strategy Framework Directive which aims to achieve environmentally healthy marine waters by 2020. This Directive includes an initiative for an overarching European Marine Observation and Data Network (EMODNet). During the one-year consultation phase that followed the release of the EU Green Paper on a Future Maritime Policy for the European Union, stakeholders gave an overwhelming positive response. Facilitating access to high quality marine data will resolve difficulties and stimulate an expansion of value-added public and commercial services, lay the foundations for sound governance and reduce uncertainties on human impact on the planet as well as of forecasts relating to the future state of the marine environment. Better and linked marine data will have an immediate impact on the planning of environmental policy and mitigation measures, and will also facilitate impact assessments and scientific work. The overall objectives of the EMODnet Physical Parameters (EMODNet PP) preparatory action is to provide access to archived and near real-time data on physical conditions in Europe's seas and oceans by means of a dedicated Pilot Portal and to determine how well the data meet the needs of users from industry, public authorities and scientists. The latter implicates that it is also an objective to identify data gaps and arguments why these gaps should be filled in future monitoring. This project will contribute towards the definition of an operational European Marine Observation and Data Network (EMODnet). This is done done by: 1. providing through a portal: a. access to marine data from measurement stations and ferryboxes. Both near real-time and archived data of time series are to be made available. b. metadata for these data sets using EMODnet/INSPIRE standards. c. metadata maps and overviews for whole sea-basins showing the availability of data and monitoring intensity of that

  9. Synthesis of PP-g-MA as compatibilizer for PP/PLA biocomposites: Thermal, mechanical and biodegradability properties

    Science.gov (United States)

    Ghozali, Muhammad; Rohmah, Elfi Nur

    2017-01-01

    A synthesis of polypropylene-graft-maleic anhydride (PP-g-MA) with benzoyl peroxide (BPO) as an initiator has been conducted in a stainless-steel reactor at 120°C for 1 hours. The composition of maleic anhydride (MA) was varied between 10-40 phr, whereas BPO was between 0.5-2.0 phr. The grafting degree (GD) was determined by calculating the MA monomer grafted into polypropylene (PP). Fourier Transform Infrared (FTIR) analysis was performed to study the functional group in the copolymer PP-g-MA. The result shows that the highest GD of 11.85% was obtained when the use of MA and BPO are 40 phr and 1 phr, respectively. PP/PLA biocomposites have been manufactured by adding polypropylene (PP), polylactic acid (PLA) and PP-g-MA as compatibilizer into rheomix at a temperature of 200-210°C with a stirring speed of 25 rpm for 7-10 minutes. PP/PLA biocomposites were varied at a ratio of 0/100, 20/80, 40/60, 60/40, 80/20 and 100/0. Fourier Transform Infrared (FTIR), Ultimate Testing Machine (UTM), Thermogravimetric Analysis (TGA) and biodegradation analysis were performed to determine the functional groups, thermal stability, tensile strength and the biodegradability level of PP/PLA biocomposites, respectively. Thermal and mechanical analysis results indicate that the addition of PLA into PP/PLA biocomposites can reduce the thermal stability and mechanical properties, however the biodegradability is increased.

  10. UHMWPE/PP-X/PP共混物滑动摩擦性能研究%STUDY ON SLIDING WEAR PROPERTIES OF UHMWPE/PP-X/PP BLENDS

    Institute of Scientific and Technical Information of China (English)

    周勇; 蔡松; 梁兵

    2008-01-01

    采用自制的交联聚丙烯(PP-X)与超高分子量聚乙烯(UHMWPE)、聚丙烯(PP)共混,对共混物的力学性能和滑动摩擦性能进行了研究.结果表明,在力学性能改变不大的情况下,当UHMWPE/PP-X/PP的质量比为80/20/10时,共混物的磨痕宽度为5.69 mm,摩擦系数为0.125,比纯UHMWPE的磨痕宽度、摩擦系数分别下降了21.73%和39.90%,比UHMWPE)/PP(100/10)共混物分别下降了2.0%和18.83%.扫描电子显微镜照片显示,在UHMWPE的磨损表面存在严重的刮痕、裂纹及磨屑,而在UHMWPE/PP-X/PP共混物的磨损表面却很少发现上述现象.

  11. Study on Mechanical Properties of PP/POE Blends%PP/POE共混物力学性能研究

    Institute of Scientific and Technical Information of China (English)

    梁基照; 马文勇

    2010-01-01

    用双螺杆挤出机制备了聚丙烯(PP)/聚烯烃弹性体(POE)共混物,研究了POE用量对PP/POE共混物冲击性能、拉伸性能及弯曲性能的影响.结果表明:随着POE含量的增加,PP/POE共混物的冲击强度明显提高;拉伸强度及拉伸模量、弯曲强度及弯曲模量、断裂伸长率及断裂强度均减小.

  12. Search for a bound K− pp system

    Directory of Open Access Journals (Sweden)

    Camerini P.

    2010-04-01

    Full Text Available Data from the K− absorption reaction on 6,7Li, 9Be, 13C and 16O have recently been collected by FINUDA at the DAΦNE φ-factory (Laboratori Nazionali di Frascati-INFN, following an earlier lower statitics run on 12C and some other targets. FINUDA is a high acceptance magnetic spectrometer which performed a wide range of studies by detecting the charged particles and neutrons exiting the targets after the absorption event. In this paper it is discussed about the study of the A(K− , Λp reaction in the context of the search for deeply bound $ar{K}$ - nuclear states. The observation of a bump in the Λp invariant mass distribution is discussed in terms of a possible signature of a deeply bound K− pp kaonic cluster as well as of more conventional physics. An overview of the experimental situation in this field will be given.

  13. PP/POE/PE/CaCO3/PP-g-MAH复合材料力学性能的研究%Study on the Mechanical Properties of PP/POE/PE/CaCO3/PP-g-MAH Composite

    Institute of Scientific and Technical Information of China (English)

    赵伟; 王丽

    2009-01-01

    采用熔融共混法制备聚丙烯,聚烯烃弹性体/聚乙烯/马来酸酐接枝聚丙烯(PP/POE/PE/CaCO3/PP-g-MAH)复合材料,并研究其力学性能.结果表明:PP-g-MAH可提高PP与CaCO3的相容性,使复合材料的韧性和拉伸性能得到提高,PE可提高PP与POE的相容性,并有效提高复合材料的韧性,经POE、PE、CaCO3和PP-g-MAH之间的相互协同改性作用可制得综合性能优良的PP复合材料.

  14. Surface treated polypropylene (PP) fibres for reinforced concrete

    Energy Technology Data Exchange (ETDEWEB)

    López-Buendía, Angel M., E-mail: buendia@uv.es [AIDICO Technological Institute of Construction, Benjamin Franklin 17, 46380 Paterna, Valencia (Spain); Romero-Sánchez, María Dolores [AIDICO Technological Institute of Construction, Marble Technical Unit, Camí de Castella 4, 03660 Novelda. Alicante (Spain); Climent, Verónica [Lafarge Cementos, Polígono Sepes, Isaac Newton s/n, 46500 Sagunto, Valencia (Spain); Guillem, Celia [AIDICO Technological Institute of Construction, Marble Technical Unit, Camí de Castella 4, 03660 Novelda. Alicante (Spain)

    2013-12-15

    Surface treatments on a polypropylene (PP) fibre have contributed to the improvement of fibre/concrete adhesion in fibre-reinforced concrete. The treatments to the PP fibre were characterized by contact angle measurements, ATR-IR and XPS to analyse chemical alterations. The surface topography and fibre/concrete interaction were analysed by several microscopic techniques, namely optical petrographic, and scanning electron microscopy. Treatment modified the surface chemistry and topography of the fibre by introducing sodium moieties and created additional fibre surface roughness. Modifications in the fibre surface led to an increase in the adhesion properties between the treated fibres and concrete and an improvement in the mechanical properties of the fibre-reinforced concrete composite as compared to the concrete containing untreated PP fibres. Compatibility with the concrete and increased roughness and mineral surface was also improved by nucleated portlandite and ettringite mineral association anchored on the alkaline PP fibre surface, which is induced during treatment.

  15. Study on Dynamic Vulcanized EPDM/PP Thermoplastic Elastomer

    Institute of Scientific and Technical Information of China (English)

    YANG ShiYuan

    2001-01-01

    @@ Based upon the THE,HAAK RHEOCORD 90 and Wx-ray observation,a study was made on the structure and property of ethylene-propylene-ethlidene norborene (EPDM)/polyprolene (PP) blending systems ,and the experimental results were fully explained. (1) The effect of Mooney viscosity (ML)of EPDM、 melt flow rate(MFR) of peroxide(DCP) and mixing steps on mechanical properties of EPDM/PP blends was studied. The results showed that the mechanical and process properties of EPDM?PP thermoplastic elastomers were better using EPDM with the ML of 60 and PP with MFR of 7.5g/10min as matrix,DCP with the content of 1.2 per cent with the help of twostep curing process at the temperature of 170-175 ℃.

  16. Study on Dynamic Vulcanized EPDM/PP Thermoplastic Elastomer

    Institute of Scientific and Technical Information of China (English)

    YANG; ShiYuan

    2001-01-01

    Based upon the THE,HAAK RHEOCORD 90 and Wx-ray observation,a study was made on the structure and property of ethylene-propylene-ethlidene norborene (EPDM)/polyprolene (PP) blending systems ,and the experimental results were fully explained.  (1) The effect of Mooney viscosity (ML)of EPDM、 melt flow rate(MFR) of peroxide(DCP) and mixing steps on mechanical properties of EPDM/PP blends was studied. The results showed that the mechanical and process properties of EPDM?PP thermoplastic elastomers were better using EPDM with the ML of 60 and PP with MFR of 7.5g/10min as matrix,DCP with the content of 1.2 per cent with the help of twostep curing process at the temperature of 170-175 ℃.……

  17. The Role of the Carbohydrate Recognition Domain of Placental Protein 13 (PP13) in Pregnancy Evaluated with Recombinant PP13 and the DelT221 PP13 Variant

    OpenAIRE

    Marei Sammar; Shahar Nisamblatt; Ron Gonen; Berthold Huppertz; Sveinbjorn Gizurarson; George Osol; Hamutal Meiri

    2014-01-01

    Introduction Placental protein 13 (PP13), a placenta specific protein, is reduced in the first trimester of pregnancy in women who subsequently develop preeclampsia. A naturally occurring PP13 deletion of thymidine at position 221 (DelT221 or truncated variant) is associated with increased frequency of severe preeclampsia. In this study we compared the full length (wildtype) PP13 and the truncated variant. Methods Full length PP13 or its DelT221 variant were cloned, expressed and purified fro...

  18. High p{sub T} jet production in pp collisions

    Energy Technology Data Exchange (ETDEWEB)

    Eskola, K.J. [Univ. of Helsinki (Finland); Wang, X.N. [Lawrence Berkeley Lab., CA (United States)

    1995-07-01

    Production rates of large p{sub T} jets in pp collisions at RHIC and LHC energies are studied using the next-to-leading order calculation of S. D. Ellis, Z. Zunszt and D. Soper. The computed inclusive one-jet cross sections are compared against the CERN and Fermilab jet data from p{bar p} and pp collisions. The dependence of the results on the choice of the parton distributions and renormalization/factorization scales is investigated.

  19. Differential cross section and analysing power of the pp -> {pp\\}_s pi0 reaction at 353 MeV

    CERN Document Server

    Tsirkov, D; Baru, V; Chiladze, D; Dymov, S; Dzyuba, A; Gebel, R; Goslawski, P; Hanhart, C; Hartmann, M; Kacharava, A; Khoukaz, A; Komarov, V; Kulessa, P; Kulikov, A; Kurbatov, V; Lensky, V; Lorentz, B; Macharashvili, G; Mchedslishvili, D; Mielke, M; Mikirtytchiants, S; Merzliakov, S; Nioradze, M; Ohm, H; Papenbrock, M; Rathmann, F; Serdyuk, V; Shmakova, V; Stroeher, H; Uzikov, Yu; Valdau, Yu; Wilkin, C

    2011-01-01

    In order to establish links between p-wave pion production in nucleon-nucleon collisions and low energy three-nucleon scattering, an extensive programme of experiments on pion production is currently underway at COSY-ANKE. The final proton pair is detected at very low excitation energy, leading to an S-wave diproton, denoted here as {pp}_s. We now report on measurements of the differential cross section and analysing power of the pol{p}p->{pp}_s pi^0$ reaction at 353 MeV. Both observables can be described in terms of s- and d-wave pion production and, by using the phase information from elastic pp scattering, unique solutions can be obtained for the corresponding amplitudes. This information is vital for the partial wave decomposition of the corresponding pn->{pp}_s pi^- reaction and hence for the extraction of the p-wave terms.

  20. PP/clay nanocomposite films for food package; Filmes de nanocomposito PP/argila organofilica para embalagens de alimentos

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Arthur R.A.; Silva, Suedina M.L., E-mail: suedina@dema.ufcg.ed [Universidade Federal de Campina Grande (UAEMat/UFCG), PB (Brazil). Unidade Academica de Engenharia de Materiais; Andrade, Daniela L.A.C.S. [Universidade Federal de Campina Grande (UFCG), PB (Brazil). Programa de Pos-Graduacao em Engenharia de Processos; Mesquita, Wandemberg B. [Felinto Industria e Comercio Ltda., Campina Grande, PB (Brazil)

    2009-07-01

    Small contents of organoclays (1 wt %) were incorporated to PP modified with maleic anhydride by melt intercalation, in order to prepare polymeric films for further applications in food package sector. The films were characterized by X-ray diffraction (XRD) and mechanical properties. The data indicates that the incorporation of organoclay to PP results in transparent films with intercalated morphology and highly. The mechanical properties of nanocomposites films were superior from those pristine films. The results evidences that the PP/PP-g-MA/organoclay nanocomposite films, prepared in this study might be promissory to the food package market and, in short time, be used like a new product by industries of this sector. (author)

  1. Synthesis of Highly Selective Submicromolar Microcystin‐Based Inhibitors of Protein Phosphatase (PP)2A over PP1

    Science.gov (United States)

    Fontanillo, Miriam; Zemskov, Ivan; Häfner, Maximilian; Uhrig, Ulrike; Salvi, Francesca; Simon, Bernd; Wittmann, Valentin

    2016-01-01

    Abstract Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin (MC) natural toxins target both phosphatases with equal potency, and their complex synthesis has complicated structure–activity relationship studies in the past. We report herein the synthesis and biochemical evaluation of 11 MC analogues, which was accomplished through an efficient strategy combining solid‐ and solution‐phase approaches. Our approach led to the first MC analogue with submicromolar inhibitory potency that is strongly selective for PP2A over PP1 and does not require the complex lipophilic Adda group. Through mutational and structural analyses, we identified a new key element for binding, as well as reasons for the selectivity. This work gives unprecedented insight into how selectivity between these phosphatases can be achieved with MC analogues. PMID:27723199

  2. Overexpression of a novel Arabidopsis PP2C isoform, AtPP2CF1, enhances plant biomass production by increasing inflorescence stem growth

    Science.gov (United States)

    Sugimoto, Hiroki; Kondo, Satoshi; Tanaka, Tomoko; Imamura, Chie; Muramoto, Nobuhiko; Hattori, Etsuko; Ogawa, Ken’ichi; Mitsukawa, Norihiro; Ohto, Chikara

    2014-01-01

    In contrast to mammals, higher plants have evolved to express diverse protein phosphatase 2Cs (PP2Cs). Of all Arabidopsis thaliana PP2Cs, members of PP2C subfamily A, including ABI1, have been shown to be key negative regulators of abscisic acid (ABA) signalling pathways, which regulate plant growth and development as well as tolerance to adverse environmental conditions. However, little is known about the enzymatic and signalling roles of other PP2C subfamilies. Here, we report a novel Arabidopsis subfamily E PP2C gene, At3g05640, designated AtPP2CF1. AtPP2CF1 was dramatically expressed in response to exogenous ABA and was expressed in vascular tissues and guard cells, similar to most subfamily A PP2C genes. In vitro enzymatic activity assays showed that AtPP2CF1 possessed functional PP2C activity. However, yeast two-hybrid analysis revealed that AtPP2CF1 did not interact with PYR/PYL/RCAR receptors or three SnRK2 kinases, which are ABI1-interacting proteins. This was supported by homology-based structural modelling demonstrating that the putative active- and substrate-binding site of AtPP2CF1 differed from that of ABI1. Furthermore, while overexpression of ABI1 in plants induced an ABA-insensitive phenotype, Arabidopsis plants overexpressing AtPP2CF1 (AtPP2CF1oe) were weakly hypersensitive to ABA during seed germination and drought stress. Unexpectedly, AtPP2CF1oe plants also exhibited increased biomass yield, mainly due to accelerated growth of inflorescence stems through the activation of cell proliferation and expansion. Our results provide new insights into the physiological significance of AtPP2CF1 as a candidate gene for plant growth production and for potential application in the sustainable supply of plant biomass. PMID:25038254

  3. Site specificity of DSP-PP cleavage by BMP1.

    Science.gov (United States)

    Yang, Robert T; Lim, Glendale L; Yee, Colin T; Fuller, Robert S; Ritchie, Helena H

    2014-08-01

    Bone morphogenic protein 1 (BMP1), a metalloproteinase, is known to cleave a wide variety of extracellular matrix proteins, suggesting that a consensus substrate cleavage amino acid sequence might exist. However, while such a consensus sequence has been proposed based on P4 to P4' (i.e. the four amino acids flanking either side of the BMP1 cleavage site; P4P3P2P1|P1'P2'P3'P4') sequence homologies between two BMP1 substrates, dentin matrix protein 1 and dentin sialoprotein phosphophoryn (DSP-PP) (i.e. xMQx|DDP), no direct testing has so far been attempted. Using an Sf9 cell expression system, we have been able to produce large amounts of uncleaved DSP-PP. Point mutations introduced into this recombinant DSP-PP were then tested for their effects on DSP-PP cleavage by either Sf9 endogenous tolloid-related protein 1 (TLR-1) or by its human homolog, BMP1. Here, we have measured DSP-PP cleavage efficiencies after modifications based on P4-P4' sequence comparisons with dentin matrix protein 1, as well as for prolysyl oxidase and chordin, two other BMP1 substrates. Our results demonstrate that any mutations within or outside of the DSP-PP P4 to P4' cleavage site can block, impair or accelerate DSP-PP cleavage, and suggest that its BMP1 cleavage site is highly conserved in order to regulate its cleavage efficiency, possibly with additional assistance from its conserved exosites. Thus, BMP1 cleavage cannot be based on a consensus substrate cleavage site.

  4. Overexpression of RelA/SpoT homologs, PpRSH2a and PpRSH2b, induces the growth suppression of the moss Physcomitrella patens.

    Science.gov (United States)

    Sato, Michio; Takahashi, Tomohiro; Ochi, Kozo; Matsuura, Hideyuki; Nabeta, Kensuke; Takahashi, Kosaku

    2015-01-01

    Two genes encoding RelA/SpoT homologs, PpRSH2a and PpRSH2b, which are involved in the synthesis of bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) for the stringent response, were isolated from the moss, Physcomitrella patens. A complementary analysis of PpRSH2a and PpRSH2b in Escherichia coli showed that these genes had ppGpp biosynthetic activity. The recombinant PpRSH2a and PpRSH2b were also shown to synthesize ppGpp in vitro. Both proteins were localized to the chloroplasts of P. patens. Expression of the PpRSH genes was induced upon treatment with abscisic acid or abiotic stresses, such as dehydration and UV irradiation. Overexpression of PpRSH2a and PpRSH2b caused suppression of the growth in response to 1% (w/v) of glucose. The present study suggests the existence of a mechanism to regulate the growth of P. patens, which is governed by plant RSH in chloroplasts.

  5. An electron paramagnetic resonance study of PP and PP/SBS blends irradiated with gamma rays

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Pedro E-mail: silva@ivic.ve; Albano, Carmen; Perera, Rosestela; Gonzalez, Jeanette; Ichazo, Miren

    2004-11-01

    Electron paramagnetic resonance (EPR) measurements of Polypropylene (PP) and its blends with a Styrene-Butadiene-Styrene (SBS) copolymer in 10, 20, 30 and 40 wt.% of SBS were carried out. The samples were irradiated in the 0{<=}D{<=}100 kGy range at a dose rate of 4.8 kGy/h. Typical spectra indicative of the formation of peroxy and alkyl radicals were obtained. The dynamics of formation and recombination of radicals in these samples could be explained using a mixed zero and first order generation-recombination fit of the total spin concentration as a function of the integral dose. The time dependence of the spin concentration was studied assuming a mixed first order fit in the decay process. The parameters obtained from the fitting are interpreted in terms of the rate of formation of free radicals at the irradiation time and in terms of the decay time of the total free radical concentration.

  6. ANALYSIS OF PP/POE BLENDS PROPERTIES%PP/POE共混物性能分析

    Institute of Scientific and Technical Information of China (English)

    杨柳

    2004-01-01

    对聚丙烯(PP)和聚烯烃弹性体(POE)共混来增韧PP的效果进行研究,通过差示扫描量热计分析了共混物熔点、结晶温度及结晶焓的变化,利用广角X射线衍射仪、透射电镜分别分析了共混物PP晶面间距和共混物中POE的粒径大小和分布.得到PP和POE不同配比共混物性能变化规律.结果也表明,POE增韧PP与POE的添加量粒径大小及分布有密切关系.

  7. 细菌应激反应中(p)ppGpp代谢的调控%Modulation of (p)ppGpp metabolism during bacterial stringent response

    Institute of Scientific and Technical Information of China (English)

    刘彪; 宁德刚

    2011-01-01

    (p)ppGpp is a well known intracellular signal that mediates bacterial stringent response to environment stresses through the change of its concentration level thus controls many important cellular processes for bacterial survival. In this review, we outline the mechanism of (p)ppGpp action, the enzyme system involved in (p)ppGpp metabolism, and summarize the signal transmission, the regulation and the diversity of (p)ppGpp metabolism. Moreover, we give a brief introduction on our achieved results recently about (p)ppGpp metabolism in cyanobacteria, and predict that a (p)ppGpp new metabolic mechanism different from those known exists in cyanobacteria.%(p)ppGpp是介导细菌细胞对环境胁迫产生应激反应的重要胞内信号,通过控制一系列重要的细胞活动使细菌得以生存.通过对蓝细菌中(p)ppGpp代谢的研究,对(p)ppGpp作用机制、控制(p)ppGpp代谢的酶系统、环境胁迫信号传递、细胞中(p)ppGpp水平的调控及其多样性进行了总结.

  8. pp-Solar Neutrino Spectroscopy Return of the Indium Detector

    CERN Document Server

    Raghavan, R S

    2001-01-01

    A new indium-loaded liquid scintillator (LS) with up to 15wt% In and high light output promises a breakthrough in the 25y old proposal for observing pp solar neutrinos (nue) by tagged nue capture in 115In. Intense background from the natural beta-decay of In, the single obstacle blocking this project till now, can be reduced by more than x100 with the new In-LS. Only non-In background remains, dramatically relaxing design criteria. Eight tons of In yields ~400 pp nue/y after analysis cuts. With the lowest threshold yet, Q=118 keV, In is the most sensitive detector of the pp nue spectrum, the long sought touchstone for nue conversion.

  9. Evidence for collective phenomena in pp collisions with CMS

    CERN Document Server

    Chen, Zhenyu

    2017-01-01

    Observation of long-range ridge-like correlations in high-multiplicity pp collisions opened up new opportunities for exploring novel QCD dynamics in small collision systems. Based on data collected in 2015 and 2016 with the CMS detector at the LHC, the second-order ($v_{2}$) and third-order ($v_{3}$) azimuthal anisotropy harmonics of $K_{s}^{0}$, $\\Lambda$ and inclusive charged particles are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For the first time in pp collisions, the $v_{2}$ signals are also extracted from multi-particle correlations, providing direct evidence of the collective nature of observed particle correlations. These results provide new insights on the origin of observed long-range correlations in pp collisions, and may shed light on how quantum fluctuations affect the proton structure at a very short time scale.

  10. Diversity in (p)ppGpp metabolism and effectors.

    Science.gov (United States)

    Liu, Kuanqing; Bittner, Alycia N; Wang, Jue D

    2015-04-01

    Bacteria produce guanosine tetraphosphate and pentaphosphate, collectively named (p)ppGpp, in response to a variety of environmental stimuli. These two remarkable molecules regulate many cellular processes, including the central dogma processes and metabolism, to ensure survival and adaptation. Work in Escherichia coli laid the foundation for understanding the molecular details of (p)ppGpp and its cellular functions. As recent studies expand to other species, it is apparent that there exists considerable variation, with respect to not only (p)ppGpp metabolism, but also to its mechanism of action. From an evolutionary standpoint, this diversification is an elegant example of how different species adapt a particular regulatory network to their diverse lifestyles.

  11. Core Drilling of shallow drillholes OL-PP72...OL-PP89 at Olkiluoto, Eurajoki 2011

    Energy Technology Data Exchange (ETDEWEB)

    Toropainen, V. [Suomen Malmi Oy, Espoo (Finland)

    2012-05-15

    Suomen Malmi Oy (Smoy) core drilled eighteen drillholes to survey the ground and bedrock conditions in the encapsulation plant building site at Olkiluoto, Eurajoki 2011. Soil quality, bedrock depth and quality of near surface bedrock were investigated in this project. The drillholes were drilled between 19th of October and 8th of November 2011. The lengths of the drillholes are mostly between 7 to 9 metres, except for the drillhole OL-PP79, which is 15 metres by length. The drillholes are 76 mm by diameter, and the core diameter is 60.2 mm. The lightweight GM75 drilling rig with rubber tracks was used. The drilling water was taken from the ONKALO area research building freshwater pipeline and sodium fluorescein was added as a label agent in the drilling water. The drillholes were not left open. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The average natural fracture frequencies of the drillcores range from 2.5 pc/m (OL-PP77) to 11.8 pc/m (OL-PP86). The average RQD ranges from 55.1 % (OL-PP86) to 96.4 % (OL-PP77). The penetrated soils are mostly ground fill (blast rock), but some clays and sands are lying below the fill layer. (orig.)

  12. The pp->p Lambda K+ and pp->p Sigma0 K+ reactions with chiral dynamics

    CERN Document Server

    Xie, Ju-Jun; Oset, E

    2011-01-01

    We report on a theoretical study of the pp->p Lambda K+ and pp->p Sigma0 K+ reactions near threshold using a chiral dynamical approach. The production process is described by single-pion and single-kaon exchange. The final state interactions of nucleon-hyperon, K-hyperon and K-nucleon systems are also taken into account. We show that our model leads to a fair description of the experimental data on the total cross section of the pp->p Lambda K+ and pp->p Sigma0 K+ reactions. We find that the experimental observed strong suppression of Sigma0 production compared to Lambda production at the same excess energy can be explained. However, ignorance of phases between some amplitudes does not allow to properly account for the nucleon-hyperon final state interaction for the pp->p Sigma0 K+ reaction. We also demonstrate that the invariant mass distribution and the Dalitz plot provide direct information about the Lambda and Sigma0 production mechanism, and can be tested by experiments at COSY or HIRFL-CSR.

  13. Physcomitrella Patens Dehydrins (PpDHNA and PpDHNC Confer Salinity and Drought Tolerance to Transgenic Arabidopsis Plants

    Directory of Open Access Journals (Sweden)

    Qilong Li

    2017-07-01

    Full Text Available Dehydrins (DHNs as a member of late-embryogenesis-abundant (LEA proteins are involved in plant abiotic stress tolerance. Two dehydrins PpDHNA and PpDHNC were previously characterized from the moss Physcomitrella patens, which has been suggested to be an ideal model plant to study stress tolerance due to its adaptability to extreme environment. In this study, functions of these two genes were analyzed by heterologous expressions in Arabidopsis. Phenotype analysis revealed that overexpressing PpDHN dehydrin lines had stronger stress resistance than wild type and empty-vector control lines. These stress tolerance mainly due to the up-regulation of stress-related genes expression and mitigation to oxidative damage. The transgenic plants showed strong scavenging ability of reactive oxygen species(ROS, which was attributed to the enhancing of the content of antioxidant enzymes like superoxide dismutase (SOD and catalase (CAT. Further analysis showed that the contents of chlorophyll and proline tended to be the appropriate level (close to non-stress environment and the malondialdehyde (MDA were repressed in these transgenic plants after exposure to stress. All these results suggest the PpDHNA and PpDHNC played a crucial role in response to drought and salt stress.

  14. Modern geothermal power: GeoPP with geothermal steam turbines

    Science.gov (United States)

    Tomarov, G. V.; Shipkov, A. A.

    2017-03-01

    The first part of the review presents information on the scale and specific features of geothermal energy development in various countries. The classification of geothermal power plant (GeoPP) process flow diagrams by a phase state of the primary heat source (a geothermal fluid), thermodynamic cycle, and applicable turbines is proposed. Features of geothermal plants using methods of flashing and steam separation in the process loop and a flowsheet and thermodynamic process of a geothermal fluid heat-to-power conversion in a GeoPP of the most widespread type using a double-flash separation are considered. It is shown that, for combined cycle power units, the specific power-to-consumption geothermal fluid ratio is 20-25% higher than that for traditional single-loop GeoPP. Information about basic chemical components and their concentration range for geothermal fluids of various formations around the world is presented. Three historic stages of improving geothermal energy technologies are determined, such as development of high-temperature geothermal resources (dry, superheated steam) and application of a two-phase wet-steam geothermal fluid in GeoPP power units with one or two expansion pressures and development of binary cycle GeoPPs. A current trend of more active use of binary power plants in GeoPP technological processes is noted. Design features of GeoPP's steam turbines and steam separating devices, determined by the use of low-potential geothermal saturated steam as a working medium, which is characterized by corrosion aggressiveness and a tendency to form deposits, are considered. Most promising Russian geothermal energy projects are determined. A list of today's most advanced geothermal turbine performance technologies is presented. By an example of a 25 MW steam turbine design, made by JSC Kaluga Turbine Works, advantages of the internal moisture separation with a special turbine-separator stage are shown.

  15. Molecular mechanism of serine/threonine protein phosphatase 1 (PP1cα-PP1r7) in spermatogenesis of Toxocara canis.

    Science.gov (United States)

    Ma, Guang Xu; Zhou, Rong Qiong; Song, Zhen Hui; Zhu, Hong Hong; Zhou, Zuo Yong; Zeng, Yuan Qin

    2015-09-01

    Toxocariasis is one of the most important, but neglected, zoonoses, which is mainly caused by Toxocara canis. To better understand the role of serine/threonine protein phosphatase 1 (PP1) in reproductive processes of male adult T. canis, differential expression analysis was used to reveal the profiles of PP1 catalytic subunit α (PP1cα) gene Tc-stp-1 and PP1 regulatory subunit 7 (PP1r7) gene TcM-1309. Indirect fluorescence immunocytochemistry was carried out to determine the subcellular distribution of PP1cα. Double-stranded RNA interference (RNAi) assays were employed to illustrate the function and mechanism of PP1cα in male adult reproduction. Real-time quantitative PCR (qPCR) showed transcriptional consistency of Tc-stp-1 and TcM-1309 in sperm-producing germline tissues and localization research showed cytoplasmic distribution of PP1cα in sf9 cells, which indicated relevant involvements of PP1cα and PP1r7 in spermatogenesis. Moreover, spatiotemporal transcriptional differences of Tc-stp-1 were determined by gene knockdown analysis, which revealed abnormal morphologies and blocked meiotic divisions of spermatocytes by phenotypic aberration scanning, thereby highlighting the crucial involvement of PP1cα in spermatogenesis. These results revealed a PP1cα-PP1r7 mechanism by which PP1 regulates kinetochore-microtubule interactions in spermatogenesis and provided important clues to identify novel drug or vaccine targets for toxocariasis control.

  16. pp-Solar Neutrino Spectroscopy: Return of the Indium Detector

    OpenAIRE

    2001-01-01

    A new indium-loaded liquid scintillator (LS) with up to 15wt% In and high light output promises a breakthrough in the 25y old proposal for observing pp solar neutrinos (nue) by tagged nue capture in 115In. Intense background from the natural beta-decay of In, the single obstacle blocking this project till now, can be reduced by more than x100 with the new In-LS. Only non-In background remains, dramatically relaxing design criteria. Eight tons of In yields ~400 pp nue/y after analysis cuts. Wi...

  17. $pp$ Elastic Scattering at LHC and Nucleon Structure

    CERN Document Server

    Islam, M M; Prokudin, A V

    2003-01-01

    High energy elastic pp differential cross section at LHC at the c.m. energy 14 TeV is predicted using the asymptotic behavior of sigma-tot(s) and rho(s), and the measured pbar-p differential cross section at sqrt{s}=546 GeV. The phenomenological investigation has progressively led to an effective field theory model that describes the nucleon as a chiral bag embedded in a quark-antiquark condensed ground state. The measurement of pp elastic scattering at LHC up to large |t| >~ 10 GeV^2 by the TOTEM group will be crucial to test this structure of the nucleon.

  18. Lambda production in p+p interactions at SPS energies

    CERN Document Server

    Wilczek, Andrzej Gabriel; Kowalski, S

    The method of analysis for determination of Lambda production in p+p interactions has been developed, described, and applied to 158 GeV/c p+p data. The procedure has been used for calculation of double-differential spectra (d2n/dydpT, d2n/dydmT, d2n/dxFdpT), single-differential distributions (dn/dy , dn/dxF), mean transverse mass , and the dependence of inverse slope parameter T on y. Finally, mean Lambda multiplicity extrapolated to 4pi has been calculeted.

  19. PP13, maternal ABO blood groups and the risk assessment of pregnancy complications.

    Directory of Open Access Journals (Sweden)

    Nandor Gabor Than

    Full Text Available BACKGROUND: Placental Protein 13 (PP13, an early biomarker of preeclampsia, is a placenta-specific galectin that binds beta-galactosides, building-blocks of ABO blood-group antigens, possibly affecting its bioavailability in blood. METHODS AND FINDINGS: We studied PP13-binding to erythrocytes, maternal blood-group effect on serum PP13 and its performance as a predictor of preeclampsia and intrauterine growth restriction (IUGR. Datasets of maternal serum PP13 in Caucasian (n = 1078 and Hispanic (n = 242 women were analyzed according to blood groups. In vivo, in vitro and in silico PP13-binding to ABO blood-group antigens and erythrocytes were studied by PP13-immunostainings of placental tissue-microarrays, flow-cytometry of erythrocyte-bound PP13, and model-building of PP13--blood-group H antigen complex, respectively. Women with blood group AB had the lowest serum PP13 in the first trimester, while those with blood group B had the highest PP13 throughout pregnancy. In accordance, PP13-binding was the strongest to blood-group AB erythrocytes and weakest to blood-group B erythrocytes. PP13-staining of maternal and fetal erythrocytes was revealed, and a plausible molecular model of PP13 complexed with blood-group H antigen was built. Adjustment of PP13 MoMs to maternal ABO blood group improved the prediction accuracy of first trimester maternal serum PP13 MoMs for preeclampsia and IUGR. CONCLUSIONS: ABO blood group can alter PP13-bioavailability in blood, and it may also be a key determinant for other lectins' bioavailability in the circulation. The adjustment of PP13 MoMs to ABO blood group improves the predictive accuracy of this test.

  20. PP13, Maternal ABO Blood Groups and the Risk Assessment of Pregnancy Complications

    Science.gov (United States)

    Than, Nandor Gabor; Romero, Roberto; Meiri, Hamutal; Erez, Offer; Xu, Yi; Tarquini, Federica; Barna, Laszlo; Szilagyi, Andras; Ackerman, Ron; Sammar, Marei; Fule, Tibor; Karaszi, Katalin; Kovalszky, Ilona; Dong, Zhong; Kim, Chong Jai; Zavodszky, Peter; Papp, Zoltan; Gonen, Ron

    2011-01-01

    Background Placental Protein 13 (PP13), an early biomarker of preeclampsia, is a placenta-specific galectin that binds beta-galactosides, building-blocks of ABO blood-group antigens, possibly affecting its bioavailability in blood. Methods and Findings We studied PP13-binding to erythrocytes, maternal blood-group effect on serum PP13 and its performance as a predictor of preeclampsia and intrauterine growth restriction (IUGR). Datasets of maternal serum PP13 in Caucasian (n = 1078) and Hispanic (n = 242) women were analyzed according to blood groups. In vivo, in vitro and in silico PP13-binding to ABO blood-group antigens and erythrocytes were studied by PP13-immunostainings of placental tissue-microarrays, flow-cytometry of erythrocyte-bound PP13, and model-building of PP13 - blood-group H antigen complex, respectively. Women with blood group AB had the lowest serum PP13 in the first trimester, while those with blood group B had the highest PP13 throughout pregnancy. In accordance, PP13-binding was the strongest to blood-group AB erythrocytes and weakest to blood-group B erythrocytes. PP13-staining of maternal and fetal erythrocytes was revealed, and a plausible molecular model of PP13 complexed with blood-group H antigen was built. Adjustment of PP13 MoMs to maternal ABO blood group improved the prediction accuracy of first trimester maternal serum PP13 MoMs for preeclampsia and IUGR. Conclusions ABO blood group can alter PP13-bioavailability in blood, and it may also be a key determinant for other lectins' bioavailability in the circulation. The adjustment of PP13 MoMs to ABO blood group improves the predictive accuracy of this test. PMID:21799738

  1. Nanocomposites of PP and bentonite clay modified with different surfactants; Nanocompositos de PP e bentonita organofilizada com diferentes tensoativos

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Andre W.B.; Agrawal, Pankaj; Araujo, Edcleide M.; Melo, Tomas J.A., E-mail: tomas@dema.ufcg.edu.b [Universidade Federal de Campina Grande (UFCG), PB (Brazil); Ueki, Marcelo M. [Servico Nacional de Aprendizagem Industrial (SENAI/CIMATEC), Salvador, BA (Brazil). Centro Integrado de Manufatura e Tecnologia

    2009-07-01

    The aim of this work was the development of nano composites of polypropylene (PP) and national bentonite clay modified with different surfactants. The results of X-Ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) showed that the organophilization process was effective. The surfactants led to a significant increase in the basal spacing of Brasgel PA clay. XRD results of the mixture PP/Brasgel PA clay modified with Praepagem WB surfactant indicated that a nanocomposite with intercalated structure was formed. When the Brasgel PA clay was modified with Praepagem HY surfactant, DRX results indicated that a micro composite was formed. Screw speed, clay content and PP viscosity had no influence on the XRD pattern of the obtained materials. (author)

  2. Effect of tocopherols incorporation on physical properties of LDPE,PP and blend film of LDPE/PP

    Directory of Open Access Journals (Sweden)

    ZHU Xuntao

    2014-12-01

    Full Text Available The objectives of this study were to investigate the effects of added tocopherols and blending of different polymers on the film physical properties.Tocopherols (3 000 mg/kg were incorporate into low density polyethylene (LDPE,polypropylene (PP and a blend film of LDPE/PP (50/50 by extrusion process.Then films were evaluated to determine tocopherol recovery and physical properties.Results showed that extrusion did not significantly change film thermal properties (Tm,Tc and Tg as compared with synthetic polymer resin pellet (raw material.LDPE and PP did not seem to react with each other to form new polymers under the current extrusion conditions.Addition of tocopherol significantly changed film mechanical properties compared with control.The above results and other data seemed to support that polymer blending is a feasible approach for producing tocopherol containing packaging films.

  3. Ueber die Reaktion pppp π+π- bei Primaerimpulsen von 12 und 24 GeV/c

    CERN Document Server

    Franz, Herbert M

    1978-01-01

    The author has studied the ppppπ+π- reaction at primary impulses of 12 to 24 GeV/c. He has obtained the mass spectra of the pπ+π- system which show evidence for diffractive production of a N*(1470) resonance together with superpositions of further resonance-like structures. Furthermore the decay of the pπ+π- system is studied by means of a momentum analysis of the decay angular distributions. Finally a partial wave analysis is performed. (HSI)

  4. Polarized proton parameters for the 2015 PP-on-Au setup in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-08-25

    Values are given for RHIC circumference shifts due to snakes for various situations. Relevant parameters are tabulated for polarized protons (PP) in the booster and in AGS and RHIC for PP-on-Au stores.

  5. Polarized proton parameters for the 2015 PP-on-Aluminum setup in RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Gardner, C. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-10-02

    Values are given for RHIC circumference shifts due to snakes for various situations. Relevant parameters are tabulated for polarized protons (PP) in the booster and in AGS and RHIC for PP-on-Aluminum stores.

  6. Genetic characterization of two fully sequenced multi-drug resistant plasmids pP10164-2 and pP10164-3 from Leclercia adecarboxylata

    Science.gov (United States)

    Sun, Fengjun; Zhou, Dongsheng; Sun, Qiang; Luo, Wenbo; Tong, Yigang; Zhang, Defu; Wang, Qian; Feng, Wei; Chen, Weijun; Fan, Yahan; Xia, Peiyuan

    2016-01-01

    We previously reported the complete sequence of the resistance plasmid pP10164-NDM, harboring blaNDM (conferring carbapenem resistance) and bleMBL (conferring bleomycin resistance), which is recovered from a clinical Leclercia adecarboxylata isolate P10164 from China. This follow-up work disclosed that there were still two multidrug-resistant (MDR) plasmids pP10164-2 and pP10164-3 coexisting in this strain. pP10164-2 and pP10164-3 were completely sequenced and shown to carry a wealth of resistance genes, which encoded the resistance to at least 10 classes of antibiotics (β-lactams. macrolides, quinolones, aminoglycosides, tetracyclines, amphenicols, quaternary ammonium compounds, sulphonamides, trimethoprim, and rifampicin) and 7 kinds of heavy mental (mercury, silver, copper, nickel, chromate, arsenic, and tellurium). All of these antibiotic resistance genes are associated with mobile elements such as transposons, integrons, and insertion sequence-based transposable units, constituting a total of three novel MDR regions, two in pP10164-2 and the other one in pP10164-3. Coexistence of three resistance plasmids pP10164-NDM, pP10164-2 and pP10164-3 makes L. adecarboxylata P10164 tend to become extensively drug-resistant. PMID:27658354

  7. Search for Exotic Processes at the CERN pp Collider

    DEFF Research Database (Denmark)

    Ansari, R.; Bagnaia, P.; Banner, M.;......Kofoed-Hansen

    1987-01-01

    The total UA2 data sample at the CERN pp̄ Collider corresponds to an integrated luminosity of 910 nb−1. Limits on various hypothetical processes, such as production of excited electrons, additional charged or neutral vector bosons, or supersymmetric particles, are presented from the analysis of t...

  8. Multiple photon effects in $pp$ scattering at SSC energies

    CERN Document Server

    Delaney, D B; Shio, C; Siopsis, G; Ward, B F L

    1992-01-01

    The Monte Carlo program SSCYFS2 is used in conjunction with available parton distribution functions to calculate the effects of multiple photon radiation on pp scattering at SSC energies. Effects relevant to precision SSC physics such as Higgs discovery and exploration are illustrated.

  9. The Hyperon Λ(1405) in p+p reactions

    Science.gov (United States)

    Siebenson, Johannes

    2011-10-01

    We present an analysis of the hyperon Λ(1405) for p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the High Acceptance Di-Electron Spectrometer (HADES). A Λ(1405) signal could be reconstructed in both charged decay channels (Λ(1405)→Σ±πmnplus;).

  10. Evidence for collectivity in pp collisions at the LHC

    Science.gov (United States)

    Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hartl, C.; Hörmann, N.; Hrubec, J.; Jeitler, M.; König, A.; Krätschmer, I.; Liko, D.; Matsushita, T.; Mikulec, I.; Rabady, D.; Rad, N.; Rahbaran, B.; Rohringer, H.; Schieck, J.; Strauss, J.; Treberer-Treberspurg, W.; Waltenberger, W.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Alderweireldt, S.; De Wolf, E. A.; Janssen, X.; Lauwers, J.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; Daci, N.; De Bruyn, I.; Deroover, K.; Heracleous, N.; Lowette, S.; Moortgat, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Parijs, I.; Brun, H.; Caillol, C.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Léonard, A.; Luetic, J.; Maerschalk, T.; Marinov, A.; Randle-conde, A.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Yonamine, R.; Zenoni, F.; Zhang, F.; Cimmino, A.; Cornelis, T.; Dobur, D.; Fagot, A.; Garcia, G.; Gul, M.; Poyraz, D.; Salva, S.; Schöfbeck, R.; Sharma, A.; Tytgat, M.; Van Driessche, W.; Yazgan, E.; Zaganidis, N.; Bakhshiansohi, H.; Beluffi, C.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; De Visscher, S.; Delaere, C.; Delcourt, M.; Francois, B.; Giammanco, A.; Jafari, A.; Jez, P.; Komm, M.; Lemaitre, V.; Magitteri, A.; Mertens, A.; Musich, M.; Nuttens, C.; Piotrzkowski, K.; Quertenmont, L.; Selvaggi, M.; Vidal Marono, M.; Wertz, S.; Beliy, N.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Hensel, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; Da Silveira, G. G.; De Jesus Damiao, D.; De Oliveira Martins, C.; Fonseca De Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Matos Figueiredo, D.; Mora Herrera, C.; Mundim, L.; Nogima, H.; Prado Da Silva, W. L.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; Dogra, S.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Fang, W.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Chen, Y.; Cheng, T.; Jiang, C. H.; Leggat, D.; Liu, Z.; Romeo, F.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Zhang, H.; Zhao, J.; Ban, Y.; Chen, G.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; Gomez, J. P.; González Hernández, C. F.; Ruiz Alvarez, J. D.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Sculac, T.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Ferencek, D.; Kadija, K.; Micanovic, S.; Sudic, L.; Susa, T.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Finger, M.; Finger, M.; Carrera Jarrin, E.; Abdelalim, A. A.; El-khateeb, E.; Salama, E.; Calpas, B.; Kadastik, M.; Murumaa, M.; Perrini, L.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Tuominiemi, J.; Tuovinen, E.; Wendland, L.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Favaro, C.; Ferri, F.; Ganjour, S.; Ghosh, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Kucher, I.; Locci, E.; Machet, M.; Malcles, J.; Rander, J.; Rosowsky, A.; Titov, M.; Zghiche, A.; Abdulsalam, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Chapon, E.; Charlot, C.; Davignon, O.; Granier de Cassagnac, R.; Jo, M.; Lisniak, S.; Miné, P.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Pigard, P.; Regnard, S.; Salerno, R.; Sirois, Y.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Agram, J.-L.; Andrea, J.; Aubin, A.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Le Bihan, A.-C.; Skovpen, K.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Bouvier, E.; Carrillo Montoya, C. A.; Chierici, R.; Contardo, D.; Courbon, B.; Depasse, P.; El Mamouni, H.; Fan, J.; Fay, J.; Gascon, S.; Gouzevitch, M.; Grenier, G.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Popov, A.; Sabes, D.; Sordini, V.; Vander Donckt, M.; Verdier, P.; Viret, S.; Toriashvili, T.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Feld, L.; Heister, A.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Ostapchuk, A.; Preuten, M.; Raupach, F.; Schael, S.; Schomakers, C.; Schulte, J. F.; Schulz, J.; Verlage, T.; Weber, H.; Zhukov, V.; Albert, A.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hamer, M.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Knutzen, S.; Merschmeyer, M.; Meyer, A.; Millet, P.; Mukherjee, S.; Olschewski, M.; Padeken, K.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Sonnenschein, L.; Teyssier, D.; Thüer, S.; Cherepanov, V.; Flügge, G.; Haj Ahmad, W.; Hoehle, F.; Kargoll, B.; Kress, T.; Künsken, A.; Lingemann, J.; Müller, T.; Nehrkorn, A.; Nowack, A.; Nugent, I. M.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Asawatangtrakuldee, C.; Beernaert, K.; Behnke, O.; Behrens, U.; Bin Anuar, A. A.; Borras, K.; Campbell, A.; Connor, P.; Contreras-Campana, C.; Costanza, F.; Diez Pardos, C.; Dolinska, G.; Eckerlin, G.; Eckstein, D.; Eren, E.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Grados Luyando, J. M.; Gunnellini, P.; Harb, A.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Karacheban, O.; Kasemann, M.; Keaveney, J.; Kleinwort, C.; Korol, I.; Krücker, D.; Lange, W.; Lelek, A.; Leonard, J.; Lipka, K.; Lobanov, A.; Lohmann, W.; Mankel, R.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Ntomari, E.; Pitzl, D.; Raspereza, A.; Roland, B.; Sahin, M. Ö.; Saxena, P.; Schoerner-Sadenius, T.; Seitz, C.; Spannagel, S.; Stefaniuk, N.; Van Onsem, G. P.; Walsh, R.; Wissing, C.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Dreyer, T.; Garutti, E.; Gonzalez, D.; Haller, J.; Hoffmann, M.; Junkes, A.; Klanner, R.; Kogler, R.; Kovalchuk, N.; Lapsien, T.; Lenz, T.; Marchesini, I.; Marconi, D.; Meyer, M.; Niedziela, M.; Nowatschin, D.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Poehlsen, J.; Sander, C.; Scharf, C.; Schleper, P.; Schmidt, A.; Schumann, S.; Schwandt, J.; Stadie, H.; Steinbrück, G.; Stober, F. M.; Stöver, M.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Vormwald, B.; Barth, C.; Baus, C.; Berger, J.; Butz, E.; Chwalek, T.; Colombo, F.; De Boer, W.; Dierlamm, A.; Fink, S.; Friese, R.; Giffels, M.; Gilbert, A.; Goldenzweig, P.; Haitz, D.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Katkov, I.; Lobelle Pardo, P.; Maier, B.; Mildner, H.; Mozer, M. U.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Röcker, S.; Roscher, F.; Schröder, M.; Shvetsov, I.; Sieber, G.; Simonis, H. J.; Ulrich, R.; Wagner-Kuhr, J.; Wayand, S.; Weber, M.; Weiler, T.; Williamson, S.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Topsis-Giotis, I.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Tziaferi, E.; Evangelou, I.; Flouris, G.; Foudas, C.; Kokkas, P.; Loukas, N.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Filipovic, N.; Bencze, G.; Hajdu, C.; Hidas, P.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Makovec, A.; Molnar, J.; Szillasi, Z.; Bartók, M.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Bahinipati, S.; Choudhury, S.; Mal, P.; Mandal, K.; Nayak, A.; Sahoo, D. K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Chawla, R.; Bhawandeep, U.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Bhardwaj, A.; Choudhary, B. C.; Garg, R. B.; Keshri, S.; Malhotra, S.; Naimuddin, M.; Nishu, N.; Ranjan, K.; Sharma, R.; Sharma, V.; Bhattacharya, R.; Bhattacharya, S.; Chatterjee, K.; Dey, S.; Dutt, S.; Dutta, S.; Ghosh, S.; Majumdar, N.; Modak, A.; Mondal, K.; Mukhopadhyay, S.; Nandan, S.; Purohit, A.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Thakur, S.; Behera, P. K.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Netrakanti, P. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Dugad, S.; Kole, G.; Mahakud, B.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sur, N.; Sutar, B.; Banerjee, S.; Bhowmik, S.; Dewanjee, R. K.; Ganguly, S.; Guchait, M.; Jain, Sa.; Kumar, S.; Maity, M.; Majumder, G.; Mazumdar, K.; Sarkar, T.; Wickramage, N.; Chauhan, S.; Dube, S.; Hegde, V.; Kapoor, A.; Kothekar, K.; Rane, A.; Sharma, S.; Behnamian, H.; Chenarani, S.; Eskandari Tadavani, E.; Etesami, S. M.; Fahim, A.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Grandi, C.; Guiducci, L.; Marcellini, S.; Masetti, G.; Montanari, A.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Albergo, S.; Chiorboli, M.; Costa, S.; Di Mattia, A.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Gori, V.; Lenzi, P.; Meschini, M.; Paoletti, S.; Sguazzoni, G.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Primavera, F.; Calvelli, V.; Ferro, F.; Lo Vetere, M.; Monge, M. R.; Robutti, E.; Tosi, S.; Brianza, L.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Ghezzi, A.; Govoni, P.; Malberti, M.; Malvezzi, S.; Manzoni, R. A.; Marzocchi, B.; Menasce, D.; Moroni, L.; Paganoni, M.; Pedrini, D.; Pigazzini, S.; Ragazzi, S.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; De Nardo, G.; Di Guida, S.; Esposito, M.; Fabozzi, F.; Iorio, A. O. M.; Lanza, G.; Lista, L.; Meola, S.; Paolucci, P.; Sciacca, C.; Thyssen, F.; Azzi, P.; Bacchetta, N.; Benato, L.; Bisello, D.; Boletti, A.; Carlin, R.; Carvalho Antunes De Oliveira, A.; Checchia, P.; Dall'Osso, M.; De Castro Manzano, P.; Dorigo, T.; Dosselli, U.; Gasparini, F.; Gasparini, U.; Gozzelino, A.; Lacaprara, S.; Margoni, M.; Meneguzzo, A. T.; Pazzini, J.; Pozzobon, N.; Ronchese, P.; Simonetto, F.; Torassa, E.; Zanetti, M.; Zotto, P.; Zucchetta, A.; Zumerle, G.; Braghieri, A.; Magnani, A.; Montagna, P.; Ratti, S. P.; Re, V.; Riccardi, C.; Salvini, P.; Vai, I.; Vitulo, P.; Alunni Solestizi, L.; Bilei, G. M.; Ciangottini, D.; Fanò, L.; Lariccia, P.; Leonardi, R.; Mantovani, G.; Menichelli, M.; Saha, A.; Santocchia, A.; Androsov, K.; Azzurri, P.; Bagliesi, G.; Bernardini, J.; Boccali, T.; Castaldi, R.; Ciocci, M. A.; Dell'Orso, R.; Donato, S.; Fedi, G.; Giassi, A.; Grippo, M. T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Cipriani, M.; D'imperio, G.; Del Re, D.; Diemoz, M.; Gelli, S.; Longo, E.; Margaroli, F.; Meridiani, P.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bartosik, N.; Bellan, R.; Biino, C.; Cartiglia, N.; Cenna, F.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Finco, L.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Shchelina, K.; Sola, V.; Solano, A.; Staiano, A.; Traczyk, P.; Belforte, S.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; La Licata, C.; Schizzi, A.; Zanetti, A.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Lee, S.; Lee, S. W.; Oh, Y. D.; Sekmen, S.; Son, D. C.; Yang, Y. C.; Lee, A.; Kim, H.; Brochero Cifuentes, J. A.; Kim, T. J.; Cho, S.; Choi, S.; Go, Y.; Gyun, D.; Ha, S.; Hong, B.; Jo, Y.; Kim, Y.; Lee, B.; Lee, K.; Lee, K. S.; Lee, S.; Lim, J.; Park, S. K.; Roh, Y.; Almond, J.; Kim, J.; Lee, H.; Oh, S. B.; Radburn-Smith, B. C.; Seo, S. h.; Yang, U. K.; Yoo, H. D.; Yu, G. B.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Ryu, M. S.; Choi, Y.; Goh, J.; Hwang, C.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Komaragiri, J. R.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Zolkapli, Z.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Hernandez-Almada, A.; Lopez-Fernandez, R.; Magaña Villalba, R.; Mejia Guisao, J.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Oropeza Barrera, C.; Vazquez Valencia, F.; Carpinteyro, S.; Pedraza, I.; Salazar Ibarguen, H. A.; Uribe Estrada, C.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Khan, W. A.; Shah, M. A.; Shoaib, M.; Waqas, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Bunkowski, K.; Byszuk, A.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Walczak, M.; Bargassa, P.; Beirão Da Cruz E Silva, C.; Di Francesco, A.; Faccioli, P.; Ferreira Parracho, P. G.; Gallinaro, M.; Hollar, J.; Leonardo, N.; Lloret Iglesias, L.; Nemallapudi, M. V.; Rodrigues Antunes, J.; Seixas, J.; Toldaiev, O.; Vadruccio, D.; Varela, J.; Vischia, P.; Afanasiev, S.; Bunin, P.; Gavrilenko, M.; Golutvin, I.; Gorbunov, I.; Kamenev, A.; Karjavin, V.; Lanev, A.; Malakhov, A.; Matveev, V.; Moisenz, P.; Palichik, V.; Perelygin, V.; Shmatov, S.; Shulha, S.; Skatchkov, N.; Smirnov, V.; Voytishin, N.; Zarubin, A.; Chtchipounov, L.; Golovtsov, V.; Ivanov, Y.; Kim, V.; Kuznetsova, E.; Murzin, V.; Oreshkin, V.; Sulimov, V.; Vorobyev, A.; Andreev, Yu.; Dermenev, A.; Gninenko, S.; Golubev, N.; Karneyeu, A.; Kirsanov, M.; Krasnikov, N.; Pashenkov, A.; Tlisov, D.; Toropin, A.; Epshteyn, V.; Gavrilov, V.; Lychkovskaya, N.; Popov, V.; Pozdnyakov, I.; Safronov, G.; Spiridonov, A.; Toms, M.; Vlasov, E.; Zhokin, A.; Bylinkin, A.; Chadeeva, M.; Chistov, R.; Rusinov, V.; Andreev, V.; Azarkin, M.; Dremin, I.; Kirakosyan, M.; Leonidov, A.; Rusakov, S. V.; Terkulov, A.; Baskakov, A.; Belyaev, A.; Boos, E.; Dubinin, M.; Dudko, L.; Ershov, A.; Gribushin, A.; Klyukhin, V.; Kodolova, O.; Lokhtin, I.; Miagkov, I.; Obraztsov, S.; Petrushanko, S.; Savrin, V.; Snigirev, A.; Blinov, V.; Skovpen, Y.; Azhgirey, I.; Bayshev, I.; Bitioukov, S.; Elumakhov, D.; Kachanov, V.; Kalinin, A.; Konstantinov, D.; Krychkine, V.; Petrov, V.; Ryutin, R.; Sobol, A.; Troshin, S.; Tyurin, N.; Uzunian, A.; Volkov, A.; Adzic, P.; Cirkovic, P.; Devetak, D.; Dordevic, M.; Milosevic, J.; Rekovic, V.; Alcaraz Maestre, J.; Barrio Luna, M.; Calvo, E.; Cerrada, M.; Chamizo Llatas, M.; Colino, N.; De La Cruz, B.; Delgado Peris, A.; Escalante Del Valle, A.; Fernandez Bedoya, C.; Fernández Ramos, J. P.; Flix, J.; Fouz, M. C.; Garcia-Abia, P.; Gonzalez Lopez, O.; Goy Lopez, S.; Hernandez, J. M.; Josa, M. I.; Navarro De Martino, E.; Pérez-Calero Yzquierdo, A.; Puerta Pelayo, J.; Quintario Olmeda, A.; Redondo, I.; Romero, L.; Soares, M. S.; de Trocóniz, J. F.; Missiroli, M.; Moran, D.; Cuevas, J.; Fernandez Menendez, J.; Gonzalez Caballero, I.; González Fernández, J. R.; Palencia Cortezon, E.; Sanchez Cruz, S.; Suárez Andrés, I.; Vizan Garcia, J. M.; Cabrillo, I. J.; Calderon, A.; Castiñeiras De Saa, J. R.; Curras, E.; Fernandez, M.; Garcia-Ferrero, J.; Gomez, G.; Lopez Virto, A.; Marco, J.; Martinez Rivero, C.; Matorras, F.; Piedra Gomez, J.; Rodrigo, T.; Ruiz-Jimeno, A.; Scodellaro, L.; Trevisani, N.; Vila, I.; Vilar Cortabitarte, R.; Abbaneo, D.; Auffray, E.; Auzinger, G.; Bachtis, M.; Baillon, P.; Ball, A. H.; Barney, D.; Bloch, P.; Bocci, A.; Bonato, A.; Botta, C.; Camporesi, T.; Castello, R.; Cepeda, M.; Cerminara, G.; D'Alfonso, M.; d'Enterria, D.; Dabrowski, A.; Daponte, V.; David, A.; De Gruttola, M.; De Roeck, A.; Di Marco, E.; Dobson, M.; Dorney, B.; du Pree, T.; Duggan, D.; Dünser, M.; Dupont, N.; Elliott-Peisert, A.; Fartoukh, S.; Franzoni, G.; Fulcher, J.; Funk, W.; Gigi, D.; Gill, K.; Girone, M.; Glege, F.; Gulhan, D.; Gundacker, S.; Guthoff, M.; Hammer, J.; Harris, P.; Hegeman, J.; Innocente, V.; Janot, P.; Kieseler, J.; Kirschenmann, H.; Knünz, V.; Kornmayer, A.; Kortelainen, M. J.; Kousouris, K.; Krammer, M.; Lange, C.; Lecoq, P.; Lourenço, C.; Lucchini, M. T.; Malgeri, L.; Mannelli, M.; Martelli, A.; Meijers, F.; Merlin, J. A.; Mersi, S.; Meschi, E.; Moortgat, F.; Morovic, S.; Mulders, M.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Ruan, M.; Sakulin, H.; Sauvan, J. B.; Schäfer, C.; Schwick, C.; Seidel, M.; Sharma, A.; Silva, P.; Sphicas, P.; Steggemann, J.; Stoye, M.; Takahashi, Y.; Tosi, M.; Treille, D.; Triossi, A.; Tsirou, A.; Veckalns, V.; Veres, G. I.; Wardle, N.; Zagozdzinska, A.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Bachmair, F.; Bäni, L.; Bianchini, L.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Lecomte, P.; Lustermann, W.; Mangano, B.; Marionneau, M.; Martinez Ruiz del Arbol, P.; Masciovecchio, M.; Meinhard, M. T.; Meister, D.; Micheli, F.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrin, G.; Perrozzi, L.; Quittnat, M.; Rossini, M.; Schönenberger, M.; Starodumov, A.; Tavolaro, V. R.; Theofilatos, K.; Wallny, R.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; De Cosa, A.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Ngadiuba, J.; Pinna, D.; Rauco, G.; Robmann, P.; Salerno, D.; Yang, Y.; Candelise, V.; Doan, T. H.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Lu, Y. J.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Chang, P.; Chang, Y. H.; Chang, Y. W.; Chao, Y.; Chen, K. F.; Chen, P. H.; Dietz, C.; Fiori, F.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Miñano Moya, M.; Paganis, E.; Psallidas, A.; Tsai, J. f.; Tzeng, Y. M.; Asavapibhop, B.; Singh, G.; Srimanobhas, N.; Suwonjandee, N.; Cerci, S.; Damarseckin, S.; Demiroglu, Z. S.; Dozen, C.; Dumanoglu, I.; Girgis, S.; Gokbulut, G.; Guler, Y.; Gurpinar, E.; Hos, I.; Kangal, E. E.; Kara, O.; Kayis Topaksu, A.; Kiminsu, U.; Oglakci, M.; Onengut, G.; Ozdemir, K.; Sunar Cerci, D.; Tali, B.; Turkcapar, S.; Zorbakir, I. S.; Zorbilmez, C.; Bilin, B.; Bilmis, S.; Isildak, B.; Karapinar, G.; Yalvac, M.; Zeyrek, M.; Gülmez, E.; Kaya, M.; Kaya, O.; Yetkin, E. A.; Yetkin, T.; Cakir, A.; Cankocak, K.; Sen, S.; Grynyov, B.; Levchuk, L.; Sorokin, P.; Aggleton, R.; Ball, F.; Beck, L.; Brooke, J. J.; Burns, D.; Clement, E.; Cussans, D.; Flacher, H.; Goldstein, J.; Grimes, M.; Heath, G. P.; Heath, H. F.; Jacob, J.; Kreczko, L.; Lucas, C.; Newbold, D. M.; Paramesvaran, S.; Poll, A.; Sakuma, T.; Seif El Nasr-storey, S.; Smith, D.; Smith, V. J.; Barducci, D.; Belyaev, A.; Brew, C.; Brown, R. M.; Calligaris, L.; Cieri, D.; Cockerill, D. J. A.; Coughlan, J. A.; Harder, K.; Harper, S.; Olaiya, E.; Petyt, D.; Shepherd-Themistocleous, C. H.; Thea, A.; Tomalin, I. R.; Williams, T.; Baber, M.; Bainbridge, R.; Buchmuller, O.; Bundock, A.; Burton, D.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Dauncey, P.; Davies, G.; De Wit, A.; Della Negra, M.; Di Maria, R.; Dunne, P.; Elwood, A.; Futyan, D.; Haddad, Y.; Hall, G.; Iles, G.; James, T.; Lane, R.; Laner, C.; Lucas, R.; Lyons, L.; Magnan, A.-M.; Malik, S.; Mastrolorenzo, L.; Nash, J.; Nikitenko, A.; Pela, J.; Penning, B.; Pesaresi, M.; Raymond, D. M.; Richards, A.; Rose, A.; Seez, C.; Summers, S.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Wright, J.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Leslie, D.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Charaf, O.; Cooper, S. I.; Henderson, C.; Rumerio, P.; West, C.; Arcaro, D.; Avetisyan, A.; Bose, T.; Gastler, D.; Rankin, D.; Richardson, C.; Rohlf, J.; Sulak, L.; Zou, D.; Benelli, G.; Berry, E.; Cutts, D.; Garabedian, A.; Hakala, J.; Heintz, U.; Hogan, J. M.; Jesus, O.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Piperov, S.; Sagir, S.; Spencer, E.; Syarif, R.; Breedon, R.; Breto, G.; Burns, D.; Calderon De La Barca Sanchez, M.; Chauhan, S.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Flores, C.; Funk, G.; Gardner, M.; Ko, W.; Lander, R.; Mclean, C.; Mulhearn, M.; Pellett, D.; Pilot, J.; Shalhout, S.; Smith, J.; Squires, M.; Stolp, D.; Tripathi, M.; Wilbur, S.; Yohay, R.; Cousins, R.; Everaerts, P.; Florent, A.; Hauser, J.; Ignatenko, M.; Saltzberg, D.; Takasugi, E.; Valuev, V.; Weber, M.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Hanson, G.; Heilman, J.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Olmedo Negrete, M.; Paneva, M. I.; Shrinivas, A.; Si, W.; Wei, H.; Wimpenny, S.; Yates, B. R.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; Derdzinski, M.; Gerosa, R.; Holzner, A.; Klein, D.; Krutelyov, V.; Letts, J.; Macneill, I.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Welke, C.; Wood, J.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Bhandari, R.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Flowers, K.; Franco Sevilla, M.; Geffert, P.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Heller, R.; Incandela, J.; Mccoll, N.; Mullin, S. D.; Ovcharova, A.; Richman, J.; Stuart, D.; Suarez, I.; Yoo, J.; Anderson, D.; Apresyan, A.; Bendavid, J.; Bornheim, A.; Bunn, J.; Chen, Y.; Duarte, J.; Lawhorn, J. M.; Mott, A.; Newman, H. B.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhu, R. Y.; Andrews, M. B.; Azzolini, V.; Ferguson, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Mulholland, T.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chaves, J.; Chu, J.; Dittmer, S.; Mcdermott, K.; Mirman, N.; Nicolas Kaufman, G.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Tan, S. M.; Tao, Z.; Thom, J.; Tucker, J.; Wittich, P.; Zientek, M.; Winn, D.; Abdullin, S.; Albrow, M.; Apollinari, G.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Cheung, H. W. K.; Chlebana, F.; Cihangir, S.; Cremonesi, M.; Elvira, V. D.; Fisk, I.; Freeman, J.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Hare, D.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kreis, B.; Lammel, S.; Linacre, J.; Lincoln, D.; Lipton, R.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Magini, N.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mrenna, S.; Nahn, S.; Newman-Holmes, C.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Ristori, L.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Stoynev, S.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Wang, M.; Weber, H. A.; Whitbeck, A.; Acosta, D.; Avery, P.; Bortignon, P.; Bourilkov, D.; Brinkerhoff, A.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; Field, R. D.; Furic, I. K.; Konigsberg, J.; Korytov, A.; Ma, P.; Matchev, K.; Mei, H.; Milenovic, P.; Mitselmakher, G.; Rank, D.; Shchutska, L.; Sperka, D.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, J. R.; Adams, T.; Askew, A.; Bein, S.; Diamond, B.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Khatiwada, A.; Prosper, H.; Santra, A.; Weinberg, M.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Bucinskaite, I.; Cavanaugh, R.; Evdokimov, O.; Gauthier, L.; Gerber, C. E.; Hofman, D. J.; Kurt, P.; O'Brien, C.; Sandoval Gonzalez, I. D.; Turner, P.; Varelas, N.; Wang, H.; Wu, Z.; Zakaria, M.; Zhang, J.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Anderson, I.; Blumenfeld, B.; Cocoros, A.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Osherson, M.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; Xin, Y.; You, C.; Al-bataineh, A.; Baringer, P.; Bean, A.; Boren, S.; Bowen, J.; Bruner, C.; Castle, J.; Forthomme, L.; Kenny, R. P., III; Kropivnitskaya, A.; Majumder, D.; Mcbrayer, W.; Murray, M.; Sanders, S.; Stringer, R.; Tapia Takaki, J. D.; Wang, Q.; Ivanov, A.; Kaadze, K.; Khalil, S.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Toda, S.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Gomez, J. A.; Hadley, N. J.; Jabeen, S.; Kellogg, R. G.; Kolberg, T.; Kunkle, J.; Lu, Y.; Mignerey, A. C.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Tonjes, M. B.; Tonwar, S. C.; Abercrombie, D.; Allen, B.; Apyan, A.; Barbieri, R.; Baty, A.; Bi, R.; Bierwagen, K.; Brandt, S.; Busza, W.; Cali, I. A.; Demiragli, Z.; Di Matteo, L.; Gomez Ceballos, G.; Goncharov, M.; Hsu, D.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Krajczar, K.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Sumorok, K.; Tatar, K.; Varma, M.; Velicanu, D.; Veverka, J.; Wang, J.; Wang, T. W.; Wyslouch, B.; Yang, M.; Zhukova, V.; Benvenuti, A. C.; Chatterjee, R. M.; Evans, A.; Finkel, A.; Gude, A.; Hansen, P.; Kalafut, S.; Kao, S. C.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Tambe, N.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bartek, R.; Bloom, K.; Claes, D. R.; Dominguez, A.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Kravchenko, I.; Malta Rodrigues, A.; Meier, F.; Monroy, J.; Siado, J. E.; Snow, G. R.; Stieger, B.; Alyari, M.; Dolen, J.; George, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Kaisen, J.; Kharchilava, A.; Kumar, A.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Baumgartel, D.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira De Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Bhattacharya, S.; Hahn, K. A.; Kubik, A.; Kumar, A.; Low, J. F.; Mucia, N.; Odell, N.; Pollack, B.; Schmitt, M. H.; Sung, K.; Trovato, M.; Velasco, M.; Dev, N.; Hildreth, M.; Hurtado Anampa, K.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Wayne, M.; Wolf, M.; Woodard, A.; Alimena, J.; Antonelli, L.; Brinson, J.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Francis, B.; Hart, A.; Hill, C.; Hughes, R.; Ji, W.; Liu, B.; Luo, W.; Puigh, D.; Winer, B. L.; Wulsin, H. W.; Cooperstein, S.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Lange, D.; Luo, J.; Marlow, D.; Medvedeva, T.; Mei, K.; Mooney, M.; Olsen, J.; Palmer, C.; Piroué, P.; Stickland, D.; Tully, C.; Zuranski, A.; Malik, S.; Barker, A.; Barnes, V. E.; Folgueras, S.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, A. W.; Jung, K.; Miller, D. H.; Neumeister, N.; Shi, X.; Sun, J.; Svyatkovskiy, A.; Wang, F.; Xie, W.; Xu, L.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Redjimi, R.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Betchart, B.; Bodek, A.; de Barbaro, P.; Demina, R.; Duh, Y. t.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Hindrichs, O.; Khukhunaishvili, A.; Lo, K. H.; Tan, P.; Verzetti, M.; Agapitos, A.; Chou, J. P.; Contreras-Campana, E.; Gershtein, Y.; Gómez Espinosa, T. A.; Halkiadakis, E.; Heindl, M.; Hidas, D.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Kyriacou, S.; Lath, A.; Nash, K.; Saka, H.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Heideman, J.; Riley, G.; Rose, K.; Spanier, S.; Thapa, K.; Bouhali, O.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Juska, E.; Kamon, T.; Mueller, R.; Pakhotin, Y.; Patel, R.; Perloff, A.; Perniè, L.; Rathjens, D.; Rose, A.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Cowden, C.; Damgov, J.; De Guio, F.; Dragoiu, C.; Dudero, P. R.; Faulkner, J.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Peltola, T.; Undleeb, S.; Volobouev, I.; Wang, Z.; Delannoy, A. G.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Melo, A.; Ni, H.; Sheldon, P.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Barria, P.; Cox, B.; Goodell, J.; Hirosky, R.; Ledovskoy, A.; Li, H.; Neu, C.; Sinthuprasith, T.; Sun, X.; Wang, Y.; Wolfe, E.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Lamichhane, P.; Sturdy, J.; Belknap, D. A.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Herndon, M.; Hervé, A.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Ojalvo, I.; Perry, T.; Polese, G.; Ruggles, T.; Savin, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.

    2017-02-01

    Measurements of two- and multi-particle angular correlations in pp collisions at √{ s} = 5 , 7, and 13TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0pb-1 (5 TeV), 6.2pb-1 (7 TeV), and 0.7pb-1 (13 TeV), were collected using the CMS detector at the LHC. The second-order (v2) and third-order (v3) azimuthal anisotropy harmonics of unidentified charged particles, as well as v2 of KS0 and Λ / Λ ‾ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the v2 values of charged hadrons (mostly pions), KS0 , and Λ / Λ ‾, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below pT ≈ 2GeV/ c. For 13 TeV data, the v2 signals are also extracted from four- and six-particle correlations for the first time in pp collisions, with comparable magnitude to those from two-particle correlations. These observations are similar to those seen in pPb and PbPb collisions, and support the interpretation of a collective origin for the observed long-range correlations in high-multiplicity pp collisions.

  11. Evidence for collectivity in pp collisions at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Khachatryan, Vardan; et al.

    2016-06-20

    Measurements of two- and multi-particle angular correlations in pp collisions at sqrt(s) = 5, 7, and 13 TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0 inverse picobarns (5 TeV), 6.2 inverse picobarns (7 TeV), and 0.7 inverse picobarns (13 TeV), were collected using the CMS detector at the LHC. The second-order (v[2]) and third-order (v[3]) azimuthal anisotropy harmonics of unidentified charged particles, as well as v[2] of K0 short and Lambda/anti-Lambda particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the v[2] values of charged hadrons (mostly pions), K0 short, and Lambda/anti-Lambda, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below pt~2 GeV/c. For 13 TeV data, the v[2] signals are also extracted from four- and six-particle correlations for the first time in pp collisions, with comparable magnitude to those from two-particle correlations. These observations are similar to those seen in pPb and PbPb collisions, and support the interpretation of a collective origin for the observed long-range correlations in high-multiplicity pp collisions.

  12. Heavy neutrinos and the $pp\\to lljj$ CMS data

    CERN Document Server

    Gluza, J

    2015-01-01

    We show that the excess in the $pp \\to ee jj$ CMS data can be naturally interpreted within the Minimal Left Right Symmetric model (MLRSM), keeping $g_L = g_R$, if CP phases and non-degenerate masses of heavy neutrinos are taken into account. As an additional benefit, a natural interpretation of the reported ratio (14:1) of the opposite-sign (OS) $pp\\to l^\\pm l^\\mp jj$ to the same-sign (SS) $pp\\to l^\\pm l^\\pm jj$ lepton signals is possible. Finally, a suppression of muon pairs with respect to electron pairs in the $pp \\to lljj$ data is obtained, in accordance with experimental data. If the excess in the CMS data survives in the future, it would be a first clear hint towards presence of heavy neutrinos in right-handed charged currents with specific CP phases, mixing angles and masses, which will have far reaching consequences for particle physics directions.

  13. New results of the Borexino experiment: pp solar neutrino detection

    Science.gov (United States)

    Davini, S.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Chepurnov, A.; D'Angelo, D.; Derbin, A.; Etenko, A.; Fomenko, K.; Franco, D.; Galbiati, C.; Ghiano, C.; Goretti, A.; Gromov, M.; Ianni, Aldo; Ianni, Andrea; Kobychev, V.; Korablev, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Lewke, T.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Meroni, E.; Misiaszek, M.; Mosteiro, P.; Muratova, V.; Oberauer, L.; Obolensky, M.; Ortica, F.; Otis, K.; Pallavicini, M.; Papp, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Rossi, N.; Salvo, C.; Schönert, S.; Simgen, H.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Vignaud, D.; Vogelaar, R. B.; Winter, J.; Wojcik, M.; Wurm, M.; Zaimidoroga, O.; Zavatarelli, S.; Zuzel, G.

    2016-07-01

    The Borexino experiment is an ultra-pure liquid scintillator detector, running at Laboratori Nazionali del Gran Sasso (Italy). Borexino has completed the real time spectroscopy of the solar neutrinos generated in the proton-proton chain in the core of the Sun. This article reviews the Borexino experiment and the first direct measurment of pp solar neutrinos.

  14. Toughening of wood plastic composite based on X-PP

    Science.gov (United States)

    Meekum, U.; Khongrit, A.

    2016-03-01

    Wood plastic composite(WPC) based on crosslinked polypropylene(X-PP)/wood flour was explored. The peroxide/silane was used as crosslinking system. The sauna incubation under moisture saturated oven was applied to accelerate the competition of the siloxy/moisture networking reaction. There were three parts of the research work; design of experiment, toughening of WPC and the effect of peroxide, silane and PP copolymer on properties of the WPC, respectively. In this published work, the toughness improvement of the composite was focused. Ultra-high molecular weight polyethylene (UHMWPE) and Ethylene propylene diene terpolymer(EPDM) were employed to improve impact strength via blending with x-PP matrix. Composites were compounded into pellets by co-rotational twin screw extruder and test specimens were prepared by injection molding. Sauna incubation at 105°C for 12 hrs in oven chamber was performed to accelerate the final silane condensation crosslink reaction. MFI, impact strength, flexural properties and heat deflection temperature measurement were conducted. Impact strength, HDT and flexural modulus were improved with increasing UHMWPE content, and the optimal values around 5-10 phr of UHMWPE were achieved. Addition of EPDM elastomer to the matrix blends, reduced flexural strength and modulus but increased impact strength. While incorporation of EPDM into the PP/UHMWPE blends was exhibited much higher impact strength than that of the PP/UHMWPE binary blends. Silane crosslinked through sauna treatment improved the impact strength. HDT were also much risen for the crosslinked composite comparing with the non-crosslinked one.

  15. Effects of PP4 suppression on the proliferation of MCF7 cells

    Institute of Scientific and Technical Information of China (English)

    NING Lifeng; LONG Zhitao; HUANG Xiuqing; SUN Lingling; SANG Jianli

    2006-01-01

    PP4, one of the few protein phosphatases associated with centrosome in cells of many species such as Drosophila, C. elegans and mammals, plays an essential role in the regulation of centrosome functions in Drosophila and C. elegans. In order to explore the role of PP4 in mammalian cells, full-length PP4 gene was obtained by RT-PCR from MCF7 cell total RNA and inserted into eukaryotic expression vector pEGFP-C1. The resultant construct pEGFP-C1-PP4 was transfected into MCF7 cells and immunostaining was carried out to confirm the centrosome localization of PP4. Then we reversely subcloned a non-conserved domain of PP4 into pXJ41 to construct an anti-sense vector pXJ41- as-PP4. By transfecting pXJ41-as-PP4 into MCF7 cells and screening with G418, we obtained a stable cell line in which PP4 expression was stably suppressed. The cell line was analyzed on cell morphology, cytoskeleton structure, growth characteristics and the mitosis process. It was found that the proliferation rate decreased and serum-dependence increased in PP4-suppressed cells. Furthermore, flow cytometry and mitotic index analysis showed that G2/M transition was prolonged. PP4 suppression resulted in abnormal interphase microtubule, formation of multipolar spindles and an increase in percentage of multinuclear cells. These results suggested that PP4 is required for centrosome function in mammalian cells.

  16. Core drilling of hydco drillholes ONK-PP262 and ONK-PP274 in ONKALO at Olkiluoto 2010

    Energy Technology Data Exchange (ETDEWEB)

    Toropainen, V. [Suomen Malmi Oy, Espoo (Finland)

    2011-10-15

    Suomen Malmi Oy (Smoy) core drilled two drillholes for HYDCO-program in ONKALO at Eurajoki, Olkiluoto in 2010. The drillhole ONK-PP262 was drilled in May 2010 and the drillhole ONK-PP274 in December 2010. The lengths of the drillholes are 25.02 and 23.88 m respectively. The drillholes are 75.7 mm by diameter. The drillholes were drilled in the investigation niche 4 at the access tunnel chainage 3747. The hydraulic DE 130 drilling rig was used. The drilling water was taken from the ONKALO drilling water pipeline and premixed sodium fluorescein was used as a label agent in the drilling water. The drillholes were measured with EMS deviation survey tool. In addition to drilling the drillcores were logged and reported by geologist. Geological logging included the following parameters: lithology, foliation, fracture parameters, fractured zones, core loss, weathering, fracture frequency, RQD and rock quality. The main rock types in the drillholes are veined gneiss and pegmatitic granite. The average fracture frequencies in both drill cores are 1.4 pcs/m. The average RQD values in the drillcores are 97.2 % (ONK-PP262) and 98.6 % (ONK-PP274). (orig.)

  17. Comparison of anti pp and pp elastic scattering with 0. 6 < t < 2. 1 GeV/sup 2/ at the CERN-ISR

    Energy Technology Data Exchange (ETDEWEB)

    Erhan, S.; Smith, A.M.; Meritet, L.; Reyrolle, M.; Vazeille, F.; Bonino, R.; Castellina, A.; Medinnis, M.; Schlein, P.E.; Sherwood, P.

    1985-02-28

    anti pp and pp elastic scattering differential cross sections are presented for momentum transfer 0.6 < t < 2.1 GeV/sup 2/ and ..sqrt..s=53 GeV. Measurements were made in the same apparatus at the CERN Intersecting Storage Rings. The anti pp and pp results are in statistical agreement with one another over the entire t range, although the point at t=1.32 GeV/sup 2/ is 1.5sigma above the pp data. The anti pp points appear to have the same shape as the predictions of Donnachie and Landshoff but are significantly lower in magnitude for 0.9 < t < 1.5 GeV/sup 2/. (orig.).

  18. Comparison of anti pp and pp elastic scattering with 0. 6

    Energy Technology Data Exchange (ETDEWEB)

    Erhan, S.; Smith, A.M. (European Organization for Nuclear Research, Geneva (Switzerland)); Meritet, L.; Reyrolle, M.; Vazeille, F. (Clermont-Ferrand-2 Univ., 63 - Aubiere (France). Lab. de Physique Corpusculaire); Bonino, R.; Castellina, A.; Medinnis, M.; Schlein, P.E.; Sherwood, P.

    1985-02-28

    anti pp and pp elastic scattering differential cross sections are presented for momentum transfer 0.6pp and pp results are in statistical agreement with one another over the entire t range, although the point at t=1.32 GeV/sup 2/ is 1.5sigma above the pp data. The anti pp points appear to have the same shape as the predictions of Donnachie and Landshoff but are significantly lower in magnitude for 0.9

  19. PP-g-(MAH-co-St)增容PA6/PP研究%Study on Toughening for PA6/PP Blends by PP-g-(MAH-co-St)

    Institute of Scientific and Technical Information of China (English)

    张甲敏; 陈军龙; 赵文庆; 廉全贵

    2013-01-01

    以马来酸酐、苯乙烯多单体熔融接枝聚丙烯(PP)[PP-g-(MAH-co-St)]为增容剂,制备了尼龙(PA)6/PP/PP-g-(MAH-co-St)共混物,研究了PP-g-(MAH-co-St)用量对共混物性能的影响。结果表明,加入一定量的PP-g-(MAH-co-St)能有效改善PA6与PP间的相容性,提高共混物的力学性能。对不同拉伸速率的拉伸试样进行了差示扫描量热分析,结果发现取向对PA6的结晶温度和熔融温度有一定影响。%The PA6/PP alloy was obtained through the compatibilization of melt grafting maleic anhydride and styrene onto polypropylene PP-g-(MAH-co-St).The effects of varied content of PP-g-(MAH-co-St) on alloy properties were studied.The results show that proper content of PP-g-(MAH-co-St) can effectively improve the compatibility of PA6 and PP,so as to improve the properties of the alloy.The tensile specimens of different rates were determined by after DSC analysis.Results show that orientation of PA6 affects the crystallization temperature and melting temperature.

  20. Non-Isothermal Crystallization of PP/HGB Composites%PP/空心玻璃微珠复合材料非等温结晶研究

    Institute of Scientific and Technical Information of China (English)

    李军伟; 赵巍; 李勇

    2012-01-01

    采用熔融共混挤出的方法,制备了聚丙烯(PP)/空心玻璃微珠(HGB)复合材料,用差示扫描量热法研究了PP和PP/HGB复合材料的非等温结晶过程,并通过Jeziorny和莫志深方程研究了非等温结晶动力学.结果表明,随降温速率的增大,PP和PP/HGB复合材料的结晶峰温和结晶度降低,结晶速率增大;HGB的加入降低了PP的结晶速率.%The polypropylene/hollow glass beads (PP/HGB) composites were prepared by a melt-extrusion method, and the non-isothermal crystallization behavior of pure PP and PP/ HGB composites was characterized via a differential scanning calorimetry (DSC). The non-isothermal crystallization kinetics of the samples were discussed by Jeziorny and Mo equations, respectively. The results show that with increasing of the cooling rate, the crystallization temperature and crystallinity of PP and PP/HGB composites decrease, while the crystallization rate increases. However, HGB reduces the crystallization rate of PP.

  1. The PP1 binding code: a molecular-lego strategy that governs specificity.

    Science.gov (United States)

    Heroes, Ewald; Lesage, Bart; Görnemann, Janina; Beullens, Monique; Van Meervelt, Luc; Bollen, Mathieu

    2013-01-01

    Ser/Thr protein phosphatase 1 (PP1) is a single-domain hub protein with nearly 200 validated interactors in vertebrates. PP1-interacting proteins (PIPs) are ubiquitously expressed but show an exceptional diversity in brain, testis and white blood cells. The binding of PIPs is mainly mediated by short motifs that dock to surface grooves of PP1. Although PIPs often contain variants of the same PP1 binding motifs, they differ in the number and combination of docking sites. This molecular-lego strategy for binding to PP1 creates holoenzymes with unique properties. The PP1 binding code can be described as specific, universal, degenerate, nonexclusive and dynamic. PIPs control associated PP1 by interference with substrate recruitment or access to the active site. In addition, some PIPs have a subcellular targeting domain that promotes dephosphorylation by increasing the local concentration of PP1. The diversity of the PP1 interactome and the properties of the PP1 binding code account for the exquisite specificity of PP1 in vivo.

  2. The role of the carbohydrate recognition domain of placental protein 13 (PP13 in pregnancy evaluated with recombinant PP13 and the DelT221 PP13 variant.

    Directory of Open Access Journals (Sweden)

    Marei Sammar

    Full Text Available Placental protein 13 (PP13, a placenta specific protein, is reduced in the first trimester of pregnancy in women who subsequently develop preeclampsia. A naturally occurring PP13 deletion of thymidine at position 221 (DelT221 or truncated variant is associated with increased frequency of severe preeclampsia. In this study we compared the full length (wildtype PP13 and the truncated variant.Full length PP13 or its DelT221 variant were cloned, expressed and purified from E-Coli. Both variants were administrated into pregnant rats at day 8 of pregnancy for slow release (>5 days through osmotic pumps and rat blood pressure was measured. Animals were sacrificed at day 15 or day 21 and their utero-placental vasculature was examined.The DelT221 variant (11 kDA lacked exon 4 and a part of exon 3, and is short of 2 amino acids involved in the carbohydrate (CRD binding of the wildtype (18 kDA. Unlike the wildtype PP13, purification of DelT221 variant required special refolding. PP13 specific poly- clonal antibodies recognized both PP13 and DelT221 but PP13 specific monoclonal antibodies recognized only the wildtype, indicating the loss of major epitopes. Wildtype PP13 mRNA and its respective proteins were both lower in PE patients compared to normal pregnancies. The DelT221 mutant was not found in a large Caucasian cohort. Pregnant rats exposed to wildtype or DelT221 PP13 variants had significantly lower blood pressure compared to control. The wildtype but not the DelT221 mutant caused extensive vein expansion.This study revealed the importance of PP13 in regulating blood pressure and expanding the utero-placental vasculature in pregnant rats. PP13 mutant lacking amino acids of the PP13 CRD domain fails to cause vein expansion but did reduce blood pressure. The study provides a basis for replenishing patients at risk for preeclampsia by the full length but not the truncated PP13.

  3. Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

    Science.gov (United States)

    Beljantseva, Jelena; Kudrin, Pavel; Jimmy, Steffi; Ehn, Marcel; Pohl, Radek; Varik, Vallo; Tozawa, Yuzuru; Shingler, Victoria; Tenson, Tanel; Rejman, Dominik; Hauryliuk, Vasili

    2017-01-01

    The alarmone nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance and virulence, making (p)ppGpp-mediated signaling a promising target for development of antibacterials. Although ppGpp itself is an activator of the ribosome-associated ppGpp synthetase RelA, several ppGpp mimics have been developed as RelA inhibitors. However promising, the currently available ppGpp mimics are relatively inefficient, with IC50 in the sub-mM range. In an attempt to identify a potent and specific inhibitor of RelA capable of abrogating (p)ppGpp production in live bacterial cells, we have tested a targeted nucleotide library using a biochemical test system comprised of purified Escherichia coli components. While none of the compounds fulfilled this aim, the screen has yielded several potentially useful molecular tools for biochemical and structural work. PMID:28157202

  4. Cytosolic ppGpp accumulation induces retarded plant growth and development.

    Science.gov (United States)

    Ihara, Yuta; Masuda, Shinji

    2016-01-01

    In bacteria a second messenger, guanosine 5'-diphosphate 3'-diphosphate (ppGpp), synthesized upon nutrient starvation, controls many gene expressions and enzyme activities, which is necessary for growth under changeable environments. Recent studies have shown that ppGpp synthase and hydrolase are also conserved in eukaryotes, although their functions are not well understood. We recently showed that ppGpp-overaccumulation in Arabidopsis chloroplasts results in robust growth under nutrient-limited conditions, demonstrating that the bacterial-like stringent response at least functions in plastids. To test if ppGpp also functions in the cytosol, we constructed the transgenic Arabidopsis expressing Bacillus subtilis ppGpp synthase gene yjbM. Upon induction of the gene, the mutant synthesizes ∼10-20-fold higher levels of ppGpp, and its fresh weight was reduced to ˜80% that of the wild type. These results indicate that cytosolic ppGpp negatively regulates plant growth and development.

  5. Smearing of chaos in sandwich pp-waves

    CERN Document Server

    Podolsky, J

    1999-01-01

    Recent results demonstrating the chaotic behavior of geodesics in non-homogeneous vacuum pp-wave solutions are generalized. Here we concentrate on motion in non-homogeneous sandwich pp-waves and show that chaos smears as the duration of these gravitational waves is reduced. As the number of radial bounces of any geodesic decreases, the outcome channels to infinity become fuzzy, and thus the fractal structure of the initial conditions characterizing chaos is cut at lower and lower levels. In the limit of impulsive waves, the motion is fully non-chaotic. This is proved by presenting the geodesics in a simple explicit form which permits a physical interpretation, and demonstrates the focusing effect. It is shown that a circle of test particles is deformed by the impulse into a family of closed hypotrochoidal curves in the transversal plane. These are deformed in the longitudinal direction in such a way that a specific closed caustic surface is formed.

  6. LDPE and PP thermal diffusivity in molten state

    Directory of Open Access Journals (Sweden)

    Genhli Yánez

    2012-10-01

    Full Text Available Experimental results are reported for measuring the thermal diffusivity of two polymer species: low density polyethylene (LDPE and polypropylene (PP. Measurements were taken in unsteady state heat flow conditions around the materials' melting temperature, using a device specially constructed for this purpose. The experimental results for the sample's temperature profile (temperature gradient product were adjusted with the theoretical results obtained by solving the heat conduction equation. Diffusivity values were α=6.92×(10^(-7 m^2⁄s for LDPE and α=5.53×(10^(-7 m^2⁄s for PP. This was pioneering work in measuring this property at high temperatures in non-stationary state heat flow conditions and should be useful in the search for improving the conditions for processing these materials.

  7. Preparation and properties of PVAc-nano-OMMT/PP-EVA composite%PVAc-nano-OMMT/PP-EVA复合材料的制备与性能

    Institute of Scientific and Technical Information of China (English)

    刘玲; 郭海福; 曾幸荣; 赖学军

    2011-01-01

    利用乳液聚合法引发醋酸乙烯酯(VAc)在有机蒙脱土(OMMT)中原位插层聚合,与聚丙烯(PP)-乙烯-醋酸乙烯酯共聚物(EVA)复合体系熔融共挤制备出PVAe-nano-0MMT/PP-EVA复合材料.X射线衍射(XRD)与透射电镜(TEM)测试结果表明,在强剪切作用下,PVAc-nano-OMMT/PP-EVA形成了剥离型纳米复合材料结构;热失重(TGA)测试结果显示PVAc-nano-OMMT/PP-EVA的起始分解温度明显高于PP-EVA和nanoOMMT/PP-EVA,PVAc-nano-OMMT的存在使材料的热性能得以改善;在PVAc-nano-OMMT/PP-EVA共混物中,PVAc-nano-OMMT具有明显的增韧作用;通过氧指数(LOI)和锥形量热(CONE)测试,PVAe-nano-OMMT/PP-EVA的氧指数为24.1%,可较大幅度地降低材料燃烧的热释放程度、有效燃烧热和烟释放过程,阻燃性能提高.%The in suit intercalated polymerization of vinyl acetate (VAc) and organophilic montmorillonite (OMMT) was initiated via emulsion polymerization and obtained polyvinylacetate (PVAc)-nano-OMMT hybrid.Twofold blend composed of PVAc-nano-OMMT/PP-EVA was prepared by twin-screw extruder way, and X-ray diffraction (XRD) result shows that the structure of PVAc-nano-OMMT/PP-EVA is be treated as exfoliated nanocomposite structure during application of higher shear stress to system, and transmission electron microscopy (TEM) observation gives the same result directly. Thermo gravimetric analysis (TGA) results show that the initial decomposition temperature of PVAc-nano-OMMT/PP-EVA is greater than that of PP-EVA and nano-OMMT/PP-EVA, the existence of PVAc-nano- OMMT makes composite better thermal stability. In the PVAc- nanoOMMT/PP-EVA composite, PVAc-nano-OMMT has better toughness. Limiting oxygen index (LOI) and cone calorimeter test indicate that LOI of PVAc-nano-OMMT/PP-EVA is 24. 1%, and has lower heat release rate,effective heat of combustion, smoke release course, and better flame retardancy.

  8. Strange baryon resonances in pp collisions measured with HADES

    Energy Technology Data Exchange (ETDEWEB)

    Siebenson, Johannes, E-mail: johannes.siebenson@ph.tum.de [Technische Universitaet Muenchen, Excellence Cluster Universe (Germany); Collaboration: HADES Collaboration; and others

    2012-12-15

    We present an analysis of the hyperons {Lambda}(1405) and {Sigma}(1385){sup + } for p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the High Acceptance Di-Electron Spectrometer (HADES). A {Lambda}(1405) signal could be reconstructed in both charged decay channels {Lambda}(1405){yields}{Sigma}{sup {+-}}{pi}{sup Minus-Or-Plus-Sign }. The obtained statistics of the {Sigma}(1385){sup + } signal allows also differential studies.

  9. Strange baryon resonances in pp collisions measured with HADES

    Science.gov (United States)

    Siebenson, Johannes

    We present an analysis of the hyperons Λ(1405) and Σ(1385) + for p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the High Acceptance Di-Electron Spectrometer (HADES). A Λ(1405) signal could be reconstructed in both charged decay channels Λ(1405)→Σ± π ∓ . The obtained statistics of the Σ(1385) + signal allows also differential studies.

  10. Color dipole chain and its hadronization in pp collision

    Institute of Scientific and Technical Information of China (English)

    赵晋全; 王群; 谢去病

    1995-01-01

    High energy pp collision is dealt with by double-string model. Each string corresponds to one initial color dipole which will radiate gluons to form color dipole chain. Such gluon radiation process is described by color dipole model. According to the quark combination rule, the total multiplicity formulae for calculating primary meson and baryon of one dipole chain are presented- The calculated yields of various final hadrons in energy range =53- 1 800GeV agree well with available data.

  11. Charmonium production in pp collisions with ALICE at the LHC

    CERN Document Server

    Hugo, Pereira Da Costa

    2016-01-01

    We report on forward-rapidity charmonium production in pp collisions at a center of mass energy $\\sqrt{s} = 13$ TeV, as measured by ALICE at the LHC. Differential cross sections for both J/{\\psi} and {\\psi}(2S) are presented as a function of the charmonium transverse momentum and rapidity. Results are compared to similar measurements performed by LHCb, to lower energy measurements and to state of the art model calculations.

  12. Multiparton interactions: From pp to pA

    CERN Document Server

    Bierlich, Christian

    2016-01-01

    In the process of understanding nuclear collisions, reliable extrapolations from pp collisions, based on Glauber models, are highly desirable, though seldomly accurate. We review the inclusion of diffractive excitations and argue that they provide an important contribution to centrality observables in pA collisions. We present a method for distinguishing between diffractively and non-diffractively wounded nucleons, and a proof-of-principle for an extrapolation of multiparton interaction models built on this.

  13. Prompt photon production in p-p collisions

    Energy Technology Data Exchange (ETDEWEB)

    Cleymans, J. [Univ. of Cape Town, Rondebosch (South Africa); Quack, E. [Gesellschaft fuer Schwerionenforschung, Darmstadt (Germany); Redlich, K. [Universitat Bielefeld (Germany)] [and others

    1995-07-01

    A systematic study of the inclusive photon cross-section in p-p collisions is presented. The dependence of the {gamma} rates on the renormalization and factorization scales is discussed. A comparison is made with experimental data for centre-of-mass energies ranging from 23 GeV to 1.8 TeV. Predictions of the cross-sections are given for two different sets of structure functions for RHIC and LHC energies.

  14. Observation of vertex factorisation breaking in central pp interactions

    CERN Document Server

    Barberis, D; Binon, Freddy G; Carney, J N; Di Bari, D; Dolgopolov, A V; Donskov, S V; Earl, B C; Elia, D; Evans, D; Fini, R A; French, Bernard R; Ghidini, B; Inaba, S; Inyakin, A V; Jacholkowski, A; Khaustov, G V; Kinashi, T; Kinson, J B; Kirk, A; Klempt, W; Kobayashi, M; Kondashov, A A; Kulchitskii, Yu A; Lednev, A A; Lenti, V; Lishin, V A; Loconsole, R A; Maljukov, S; Manzari, V; Martinengo, P; Minashvili, I A; Nakagawa, T; Navach, F; Norman, K L; Peigneux, J P; Polovnikov, S A; Polyakov, V A; Prokoshkin, Yu D; Romanovsky, V I; Rotscheidt, Herbert; Rusakovitch, N A; Samoylenko, V D; Semenov, A A; Sené, M; Sené, R; Shagin, P M; Shimizu, H M; Shtannikov, A V; Singovsky, A V; Soloviev, A S; Stroot, Jean-Pierre; Sugonyaev, V P; Takamatsu, K; Tchlatchidze, G A; Tsuru, T; Vasileiadis, G; Venables, M; Villalobos Baillie, O; Votruba, M F; Yasu, Y

    1996-01-01

    Central \\pipi events produced in pp interactions are studied in terms of correlations between the outgoing protons. It is observed there is more $\\rho^{0}$(770) and \\fmeson production in reactions where the outgoing protons %fastest and slowest particles in the laboratory frame are on opposite sides of the beam. This effect is not attributable to the trigger or the experimental acceptance, and suggests that the vertices do not factorise.

  15. Inclusive production of non-strange mesons in pp annihilations

    CERN Document Server

    Hamatsu, R; Barreiro, F; Cerrada, M; Cooper, A M; De Guevara, P L; Defoix, C; Díaz, J; Dobrzynski, L; Ferrando, A; Ganguli, S N; Gurtu, A; Malhotra, P K; Montanet, Lucien; Nacasch, R; Raghavan, R; Rubio, J A; Subramanian, A

    1977-01-01

    A study of the inclusive production of pi /sup -/, eta , rho /sup 0/, omega and f mesons in pp annihilation at 0.7 GeV/c is presented. Topological and channel cross sections are determined. Longitudinal and transversal momentum distributions of non-strange mesons are studied. It is deduced that nearly 48% of all negative pions arise from the decay of eta , rho /sup 0/, omega and f mesons. (22 refs).

  16. Dilepton production in pp and CC collisions with HADES

    CERN Document Server

    Fröhlich, I; Agodi, C; Balanda, A; Bellia, G; Belver, D; Belyaev, A; Blanco, A; Böhmer, M; Boyard, J L; Braun-Munzinger, P; Cabanelas, P; Castro, E; Chernenko, S P; Christ, T; Destefanis, M; Daz, J; Dohrmann, F; Durán, I; Eberl, T; Fabbietti, L; Fateev, O V; Finocchiaro, P; Fonte, Paulo J R; Friese, J; Galatyuk, T; Garzn, J A; Gernhuser, R; Gilardi, C; Golubeva, M; Gonzalez-Diaz, D; Grosse, E; Guber, F; Hadjivasiliou, C; Heilmann, M; Hennino, T; Holzmann, R; Ierusalimov, A; Iori, I; Ivashkin, A; Jurkovic, M; Kmpfer, B; Kanaki, K; Karavicheva, T; Kirschner, D; König, I; König, W; Kolb, B W; Kotte, R; Krizek, F; Krcken, R; Kugler, A; Khn, W; Kurepin, A; Lamas-Valverde, J; Lang, S; Lange, S; López, L; Mangiarotti, A; Marn, J; Markert, J; Metag, V; Michalska, B; Mishra, D; Moriniere, E; Mousa, J; Münch, M; Müntz, C; Naumann, Lutz; Novotny, R; Otwinowski, J; Pachmayer, Y C; Palka, M; Pechenov, V; Perez, T; Pietraszko, J; Pleskac, R; Pospsil, V; Przygoda, W; Ramstein, B; Reshetin, A; Roy-Stephan, M; Rustamov, A; Sadovskii, A; Sailer, B; Salabura, P; Schmah, A; Senger, P; Shileev, K A; Simon, R; Spataro, S; Spruck, B; Ströbele, H; Stroth, J; Sturm, C; Sudol, M; Teilab, K; Tlustý, P; Traxler, M; Trebacz, R; Tsertos, H; Veretenkin, I; Wagner, V; Wen, H; Wisniowski, M; Wojcik, T; Wüstenfeld, J; Zanevsky, Y; Zumbruch, P

    2007-01-01

    Dilepton production has been measured with HADES, the "High Acceptance DiElectron Spectrometer". In pp collisions at 2.2GeV kinetic beam energy, exclusive eta production and the Dalitz decay eta -> gamma e+e- has been reconstructed. The electromagnetic form factor is well in agreement with existing data. In addition, an inclusive e+e- spectrum from the C+C reaction at 2AGeV is presented and compared with a thermal model.

  17. Color screening, absorption and $\\sigma_{tot}^{pp}$ at LHC

    CERN Document Server

    Fiore, R; Zoller, V R

    2014-01-01

    We show that a growth of the proton-proton total cross section with energy can be entirely attributed to the purely perturbative mechanism. The infrared regularization at rather short distances, $R_c\\simeq 0.3$ fm, allows to extend the BFKL technique from deep inelastic to hadron-hadron scattering. With the account of the absorption corrections our results are in agreement with the LHC data on $\\sigma_{tot}^{pp}$.

  18. Probing TMDs in heavy quarkonium production in $pp$ collision

    CERN Document Server

    Mukherjee, Asmita

    2016-01-01

    We present a recent calculation of $J/\\psi$ and $\\Upsilon$ production in unpolarized $pp$ collision and show that this can be used to probe the unpolarized gluon as well as the linearly polarized gluon transverse momentum dependent parton distributions (TMDs). We use the color evaporation model for the heavy quarkonium production and use a generalized factorized form of the cross section. We compare the results with experimental data.

  19. Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals.

    Science.gov (United States)

    Pei, J J; Sersen, E; Iqbal, K; Grundke-Iqbal, I

    1994-08-29

    Microtubule-associated protein tau is abnormally hyperphosphorylated in the brain of patients with Alzheimer disease (AD). Previous studies have shown (i) that in vitro tau can be phosphorylated to an Alzheimer abnormally phosphorylated state-like protein by proline-directed protein kinases MAP kinase and p34cdc2, and (ii) that the AD abnormally phosphorylated tau can be in vitro dephosphorylated by protein phosphatases PP-2B, PP-2A and PP-1 and not by PP-2C. However, to have a direct effect on the regulation of phosphorylation of tau, these enzymes should be present in the affected neurons. In the present study immunocytochemical localization of protein phosphatases PP-1, PP-2A, PP-2B and PTP, and protein kinases MAP kinase and p34cdc2 were studied in the hippocampal formation of AD and as a control in non-demented elderly patients. All the protein phosphatases and protein kinases studied were localized to both granular and pyramidal neurons. In the pyramidal neurons, the enzymes staining was observed in neuronal soma and neurites. PTP-1B, PP-1 and PP-2A were also highly expressed in microglia. The topographical distributions of all the enzymes studied were similar, i.e. the intensity of immunostaining in hippocampus in end-plate (CA3 and CA4) > prosubiculum, subiculum > entorhinal cortex > dentate gyrus > CA2 > CA1. Furthermore, the expression of all the enzymes was also observed in the tangle-bearing neurons. The PP-2B staining of the tangle-bearing neurons was weaker than the unaffected neurons in the same tissue section field in AD cases.

  20. BQP_p = PP for integer p > 2

    CERN Document Server

    Bebel, Joseph

    2011-01-01

    There's something really strange about quantum mechanics. It's not just that cats can be dead and alive at the same time, and that entanglement seems to violate the principle of locality; quantum mechanics seems to be what Aaronson calls "an island in theoryspace", because even slight perturbations to the theory of quantum mechanics seem to generate absurdities. In [Aar 04] and [Aar 05], he explores these perturbations and the corresponding absurdities in the context of computation. In particular, he shows that a quantum theory where the measurement probabilities are computed using p-norm instead of the standard 2-norm has the effect of blowing up the class BQP (the class of problems that can be efficiently solved on a quantum computer) to at least PP (the class of problems that can be solved in probabilistic polynomial time). He showed that PP \\subseteq BQP_p \\subseteq PSPACE for all constants p != 2, and that BQP_p = PP for even integers p > 2. Here, we show that this equality holds for all integers p > 2.

  1. Repo-Man/PP1 regulates heterochromatin formation in interphase

    Science.gov (United States)

    de Castro, Inês J.; Budzak, James; Di Giacinto, Maria L.; Ligammari, Lorena; Gokhan, Ezgi; Spanos, Christos; Moralli, Daniela; Richardson, Christine; de las Heras, Jose I.; Salatino, Silvia; Schirmer, Eric C.; Ullman, Katharine S.; Bickmore, Wendy A.; Green, Catherine; Rappsilber, Juri; Lamble, Sarah; Goldberg, Martin W.; Vinciotti, Veronica; Vagnarelli, Paola

    2017-01-01

    Repo-Man is a protein phosphatase 1 (PP1) targeting subunit that regulates mitotic progression and chromatin remodelling. After mitosis, Repo-Man/PP1 remains associated with chromatin but its function in interphase is not known. Here we show that Repo-Man, via Nup153, is enriched on condensed chromatin at the nuclear periphery and at the edge of the nucleopore basket. Repo-Man/PP1 regulates the formation of heterochromatin, dephosphorylates H3S28 and it is necessary and sufficient for heterochromatin protein 1 binding and H3K27me3 recruitment. Using a novel proteogenomic approach, we show that Repo-Man is enriched at subtelomeric regions together with H2AZ and H3.3 and that depletion of Repo-Man alters the peripheral localization of a subset of these regions and alleviates repression of some polycomb telomeric genes. This study shows a role for a mitotic phosphatase in the regulation of the epigenetic landscape and gene expression in interphase. PMID:28091603

  2. Charmonia production in p+p collisions under NRQCD formalism

    CERN Document Server

    Kumar, Vineet

    2016-01-01

    This work presents the differential charmonia production cross sections in high energy p+p collisions calculated using NRQCD formalism. The NRQCD formalism, factorizes the quarkonia production cross sections in terms of short distance QCD cross sections and long distance matrix elements (LDMEs). The short distance crosssections are calculated in terms of perturbative QCD and LDMEs are obtained by fitting the experimental data. Measured transverse momentum distributions of $\\chi_{\\rm c}$, $\\psi$(2S) and J/$\\psi$ in p +{$\\bar {\\rm p}$} collisions at $\\sqrt{s}=$ 1.8, 1.96 TeV and in p+p collisions at $\\sqrt{s}=$ 7, 8 and 13 TeV are used to constrain LDMEs. The feed-down contribution to each state from the higher states are taken into account. The formalism provides a very good description of the data in a wide energy range. The values of LDMEs are used to predict the charmonia cross sections in p+p collisions at 13 TeV in kinematic bins relevant for the LHC detectors. Charmonia ratios are predicted at 1.8, 5 and...

  3. Two-pion-exchange and other higher-order contributions to the $pp\\to pp\\pi^0$ reaction

    CERN Document Server

    Kim, Y; Myhrer, F; Kubodera, K

    2008-01-01

    Much effort has been invested on effective-field-theoretical studies of the near-threshold NN \\to NN\\pi reactions and, in order to deal with the rather large three-momentum transfers involved, the momentum counting scheme was proposed as an alternative to the usual Weinberg counting scheme. To examine the practical utility of the momentum counting scheme, we study here the contributions of higher-order terms to the pp\\to pp\\pi^0 reaction. We discuss the consequences of the different treatments of the nucleon propagators in these two counting schemes. We also investigate certain higher chiral-order pion-rescattering terms and the five-point counter-term, which turn out to give important contributions.

  4. Recycled and Virgin HDPEs as Bleed Inhibitors and Their Rheological Influences on Lubricating Greases Thickened with PP and mPP

    Directory of Open Access Journals (Sweden)

    Ravi Dixena

    2014-12-01

    Full Text Available Polypropylene (PP thickened lubricating grease exhibits high oil bleed tendency at low temperatures, which makes it a promising candidate for low temperature applications. At elevated temperatures, PP thickened lubricating grease exhibits excessive oil bleeding, which limits its use at high temperatures. Excessive oil bleed adversely affects the lubricating performance of the PP thickened grease. The present work is focused on the study of the oil bleed tendency of PP and Maleated Polypropylene (mPP thickened greases at various temperatures by incorporating virgin and recycled high density polyethylene (HDPE into the thickener system. Grease containing various percentages of PP and mPP thickeners were prepared and modified with different percentages of virgin and recycled HDPE. Polymers were characterized through differential scanning calorimetry (DSC techniques. The oil bleed performance of these greases was evaluated by the conical sieve method (ASTM D 6184 at various temperatures. Storage (G′ and loss modulus (G″ of greases was determined by rheometry at 25 °C. Incorporation of HDPE and recycled HDPE in PP thickened grease decreased oil bleeding compared to the base grease.

  5. Studies on the preparation of multi-monomer grafted PP by one-step extrusion and the blends with PVC

    Directory of Open Access Journals (Sweden)

    2008-01-01

    Full Text Available Firstly, a novel grafted polypropylene (PP was prepared by one step free-radical melt grafting way in a single-screw extruder. The results were shown that the addition of St to the melt-grafting system as a comonomer could significantly enhance MMA grafting degree onto PP and reduce the degradation of PP matrix by means of FTIR and MFR test, respectively. Then, the extruded multi-monomer grafted PP, as a component, directly blend with poly (vinyl chloride (PVC, named as gPP/PVC. The corresponding improved compatibility was examined. Comparison with pure PP/PVC blends, due to the addition of gPP, the tensile strengths of gPP/PVC blends increased significantly and the impact strengths were unchanged as those of pure PP/PVC blends. The DSC results also suggested that the compatibility of PP/PVC blends were improved largely.

  6. Ratio of Real to Imaginary for pp and (p)p Elastic Scatterings in QCD Inspired Model

    Institute of Scientific and Technical Information of China (English)

    LU Juan; MA Wei-Xing; HE Xiao-Rong

    2007-01-01

    We use the QCD inspired model to analyze the ratio of the real to the imaginary for pp and 5p elastic scatterings. A calculation for the ratio of the real to the imaginary is performed in which the contributions from gluongluon interaction, quark-quark interaction, quark-gluon interaction, and odd eikonal profile function are included. Our results show that the QCD inspired model gives a good fit to the LHC experimental data.

  7. Protein phosphatase PP1γ2 in sperm morphogenesis and epididymal initiation of sperm motility

    Institute of Scientific and Technical Information of China (English)

    Rumela Chakrabarti; Lina Cheng; Pawan Puri; David Soler; Srinivasan Viiayaraghavan

    2007-01-01

    The serine/threonine phosphatase (PP1) isoform PP1γ2, predominantly expressed in the testis, is a key enzyme in spermatozoa. High PP1γ2 catalytic activity holds motility in check in immature spermatozoa. Inhibition of PP1γ2 causes motility initiation in immature spermatozoa and motility stimulation and changes in flagellar beat parameters in mature spermatozoa. The PP1γ2 isoform is present in all mammalian spermatozoa studied: mouse, rat, hamster,bovine, non-human primate and man. We have now identified at least four of its regulatory proteins that regulate distinct pools of PP1γ2 within spermatozoa. Our studies provide new insights into biochemical mechanisms underlying development and regulation of sperm motility. We hypothesize that changes in sperm PP1γ2 activity as a result of phosphorylation and reversible binding of the regulatory proteins to the catalytic subunit are critical in the development and regulation of motility and the ability of sperm to fertilize eggs. Targeted disruption of the Ppp1cc gene,which encodes the PP1γ1 or PP1γ2 isoforms, causes male infertility in mice as a result of impaired spermiogenesis.Our observations suggest that, in addition to motility, the protein phosphatase PP1γ2 might play an isoform-specific function in the development of specialized flagellar structures of mammalian spermatozoa.

  8. PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte.

    Science.gov (United States)

    Tang, An; Shi, Peiliang; Song, Anying; Zou, Dayuan; Zhou, Yue; Gu, Pengyu; Huang, Zan; Wang, Qinghua; Lin, Zhaoyu; Gao, Xiang

    2016-06-02

    Studies using in vitro cultured oocytes have indicated that the protein phosphatase 2A (PP2A), a major serine/threonine protein phosphatase, participates in multiple steps of meiosis. Details of oocyte maturation regulation by PP2A remain unclear and an in vivo model can provide more convincing information. Here, we inactivated PP2A by mutating genes encoding for its catalytic subunits (PP2Acs) in mouse oocytes. We found that eliminating both PP2Acs caused female infertility. Oocytes lacking PP2Acs failed to complete 1(st) meiotic division due to chromosome misalignment and abnormal spindle assembly. In mitosis, PP2A counteracts Aurora kinase B/C (AurkB/C) to facilitate correct kinetochore-microtubule (KT-MT) attachment. In meiosis I in oocyte, we found that PP2Ac deficiency destabilized KT-MT attachments. Chemical inhibition of AurkB/C in PP2Ac-null oocytes partly restored the formation of lateral/merotelic KT-MT attachments but not correct KT-MT attachments. Taken together, our findings demonstrate that PP2Acs are essential for chromosome alignments and regulate the formation of correct KT-MT attachments in meiosis I in oocytes.

  9. Potential existence of two independent centrosome- targeting domains in PP4

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Protein phosphatase 4 (PP4) is an important member in the PPP family of protein Ser/Thr phosphatases. It has been proven to regulate a variety of cellular processes such as centrosome maturation, microtubule nucleation, splicesome assembly, and JNK pathway activation. Compared to the crystallized and structurally well defined phosphatase PP1 and PP2B, little is known about the structure of PP4. Besides the conserved motifs characteristic of the PPP family, no information is available on the other domains of PP4. PP4 is reported to localize to the centrosome in many species such as Drosophila, Caenorhabditis elegans and mammalian cells, which suggests a conserved role of PP4 in the regulation of centrosome function. Unlike several other centrosomal proteins, no sequence has been identified for PP4 that can target it to specific centrosomal localization. In this study, we used a combination of PCR mutagenesis and transient expression of GFP-tagged proteins in mammalian cells, and identified two PP4 centrosome-targeting domains of 68―136 and 134―220 aa. These two domains may be associated for appropriate localization to the centrosome. The findings are useful for further elucidating the function of the domains and other structural characteristics of PP4.

  10. Structural Basis for the Catalytic Activity of Human Serine/Threonine Protein Phosphatase type 5 (PP5)

    Science.gov (United States)

    Swingle, Mark R.; Ciszak, Ewa M.; Honkanen, Richard E.

    2004-01-01

    Serine/threonine protein phosphatase-5 (PP5) is a member of the PPP-gene family of protein phosphatases that is widely expressed in mammalian tissues and is highly conserved among eukaryotes. PP5 associates with several proteins that affect signal transduction networks, including the glucocorticoid receptor (GR)-heat shock protein-90 (Hsp90)-heterocomplex, the CDC16 and CDC27 subunits of the anaphase-promoting complex, elF2alpha kinase, the A subunit of PP2A, the G12-alpha / G13-alpha subunits of heterotrimeric G proteins and DNA-PK. The catalytic domain of PP5 (PP5c) shares 35-45% sequence identity with the catalytic domains of other PPP-phosphatases, including protein phosphatase-1 (PP1), -2A (PP2A), -2B / calcineurin (PP2B), -4 (PP4), -6 (PP6), and -7 (PP7). Like PP1, PP2A and PP4, PP5 is also sensitive to inhibition by okadaic acid, microcystin, cantharidin, tautomycin, and calyculin A. Here we report the crystal structure of the PP5 catalytic domain (PP5c) at a resolution of 1.6 angstroms. From this structure we propose a mechanism for PP5-mediated hydrolysis of phosphoprotein substrates, which requires the precise positioning of two metal ions within a conserved Asp(sup 271)-M(sub 1):M(sub 2)-W(sup 1)-His(sup 304)-Asp(sup 274) catalytic motif. The structure of PP5c provides a possible structural basis for explaining the exceptional catalytic proficiency of protein phosphatases, which are among the most powerful known catalysts. Resolution of the entire C-terminus revealed a novel subdomain, and the structure of the PP5c should also aid development of type-specific inhibitors.

  11. PP/HDPE共混体系毛细管流变性能研究%Study of Capillary Rheological Properties of PP/HDPE Blends

    Institute of Scientific and Technical Information of China (English)

    陶国良; 刘涌; 廖华勇; 纪波印; 李靖

    2012-01-01

    用毛细管流变仪对以马来酸酐接枝聚丙烯(PP-g-MAH)为相容剂的聚丙烯/高密度聚乙烯(PP/HDPE)共混体系的流变性能进行研究.研究发现,PP/HDPE共混体系属于假塑性流体:随着剪切速率的增加,表观黏度下降:PP-g-MAH的加入降低了共混体系的表观粘度:HDPE与PP的非牛顿指数在低剪切速事区与适宜强度下适用于幂律方程的经验公式;HDPE与PP共混后,HDPE含量越低,体系出现壁面滑移的临界剪切速率越高,可加工性能越好.%The rhealogical properties of PP/HDPE blends which was combined by PP-g-MAH ,were studied by capiiiary rheometer. The results show thai the rheological behavior of PP/HDPE blends is non-Newtonian fluid. With the increase of shear rate, the apparent viscosity drops. The apparent viscosity of the blends reduce with the added of PP-g-MAH. For the non-Newtonian index, the power law is applicable to HDPE and PP, white in low shear rate and the temperature is suitable. The critical shear rate in wall slip of PP/HDPE blends increases while the content of HDPE reduce. The property of process performance is better.

  12. Mechanical Properties of r-PET/PP Blends Compatibilized by PP-g-MA and Its Mixture%PP-g-MA及其混合相容剂增容r-PET/PP共混物的力学性能

    Institute of Scientific and Technical Information of China (English)

    王春广; 林劲新; 章自寿; 麦堪成

    2013-01-01

    In order to develop PP blends with recycled polyethylene terephthalate (r-PET) , the blends of r-PET with compatibilizer, r-PET/PP and compatibilized r-PET/PP blends were prepared. PP-g-MA and its mixture of POE-g-MA or EVA-g-MA with same functional group were used as compatibilizers. The tensile strength, flexural strength and modulus and impact strength of blends were characterized. The effect of compatibilizer and r-PET on mechanical properties of blends was studied. The results indicated that the mechanical properties of r-PET decreased by adding compatibilizer. But the tensile strength, flexural strength and modulus of iPP increased by introduction of r-PET, and the mechanical properties of r-PET/ iPP blends increased by adding compatibilization of PP-g-MA further. The increased mechanical properties of uncompatibilized and compatibilized r-PET/iPP blends with increasing r-PET contents indicated the presence of reinforcement of r-PET in the iPP matrix. The r-PET/iPP blends with high strength and high toughness could be obtained by compatibilization of mixture of compatibilizers. Addition of POE-g-MA or EVA-g-MA increased the impact strength of PP-g-MA compatibilized r-PET/PP blends. The r-PET/PP blends with high performance could be obtained by compatibilization of mixture PP-g-MA and POE-g-MA.%为利用废弃PET(r-PET)发展r-PET/PP共混物,该文制备了不同r-PET/相容剂、r-PET/PP和PP-g-MA及其混合相容剂增容r-PET/PP共混物,研究了以上共混物的拉伸、弯曲和冲击性能,讨论了不同相容剂对r-PET力学性能,r-PET对PP力学性能和增容共混物力学性能的影响.结果表明相容剂加入降低r-PET力学性能,r-PET提高PP拉伸和弯曲性能,r-PET/PP共混物的拉伸和弯曲性能随r-PET用量增加而提高,表明r-PET对PP中具有增强作用.PP-g-MA加入提高r-PET/PP共混物拉伸和弯曲性能,POE-g-MA和EVA-g-MA加入提高PP-g-MA增容r-PET/PP共混物冲击强度,采用混杂相容剂可获得综

  13. 颗粒内受限聚合法制备PP/POE/PS合金%Preparation of PP/POE/PS Ternary Alloys via Diffusion and Polymerization of Styrene in PP/POE Alloys

    Institute of Scientific and Technical Information of China (English)

    姚雪容; 郭朝霞; 于建

    2012-01-01

    Polypropylene/ethylene octene copolymer/polystyrene ( PP/POE/PS) ternary alloys were prepared via diffusion and subsequent polymerization of styrene ( St) in PP/POE alloy granules. St could diffuse into the center of the PP/POE alloy granules and PS phases mostly included in POE phases with a particle size from several tens of nanometers to several hundred nanometers. The size of PS particles was influenced by the amount of styrene adsorbed and the size of the POE phases. The PS particles in POE phases formed in the center of the granules were the smallest. The diffusion and polymerization process of St in PP/POE ( mass ratio, 80: 20) was studied. The diffusion rate and the maximum adsorption of styrene in PP/POE were larger than those in pure PP as existence of amorphous POE phase was beneficial for diffusion of monomer. The content of PS in PP/POE/PS alloys can be tailored by changing the amount of monomer. Incorporation of PS into POE domains made the POE domains bigger and then resulted in lower melting temperatures and crystalline temperatures of PP, and PS dispersed in PP/POE/PS with a high PS content acted as a nucleation agent of PP.%以等规聚丙烯/乙烯-辛烯共聚物(PP/POE)合金颗粒为扩散基体,苯乙烯(St)为扩散单体,利用颗粒内受限聚合法制备了PP/POE/PS三元合金.结果表明,对于POE质量分数为20%~40%的PP/POE合金颗粒,St均可扩散至直径为4 mm的颗粒中心部位,在POE非晶相中生成相尺寸为几十至几百纳米的PS球.在PP/POE合金颗粒的不同部位,因POE相尺寸及单体的吸附量不同,生成的PS相尺寸也不同,在颗粒中心部位生成的PS球最小.研究了St在PP/POE(质量比80∶20)颗粒中的扩散-聚合行为,结果表明,St在合金颗粒中的扩散速率和扩散饱和值远大于在纯PP颗粒中的扩散速率和饱和值,这主要是因为PP/POE合金颗粒中的非晶POE相有利于扩散.改变单体投料量可以获得具有不同PS含量的PP/POE/PS三

  14. Tailored sPP/Silica Nanocomposite for Ecofriendly Insulation of Extruded HVDC Cable

    Directory of Open Access Journals (Sweden)

    Bin Dang

    2015-01-01

    Full Text Available Cross-linked polyethylene (XLPE is a thermosetting material that cannot be recycled at the end of its lifetime. This study investigated the potential of syndiotactic polypropylene (sPP/silica as an ecofriendly extruded insulation system for HVDC cables. We investigated the morphology, Fourier transform infrared, and thermal, thermomechanical, and electrical behaviors of sPP modified with 0.5–3% nanosilica. We found that the silica/sPP nanocomposite without cross-linking offered a suitable mechanical modulus at room temperature and sufficient intensity at high temperatures, and adding nanosilica modified by a silane coupling agent to the sPP resulted in significant DC resistivity and space charge improvement. The optimal nanosilica content in the sPP was determined by balancing the mechanical and thermomechanical characteristics and the DC resistivity. The sPP/silica nanocomposite reported here shows great potential as a candidate insulation material for future ecofriendly extruded HVDC cables.

  15. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    Energy Technology Data Exchange (ETDEWEB)

    Soon, Fen-Fen; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M.H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun; Yong, Eu-Leong; Cutler, Sean; Zhu, Jian-Kang; Griffin, Patrick R.; Melcher, Karsten; Xu, H. Eric (Van Andel); (Scripps); (NWU); (Purdue); (UCR); (Chinese Aca. Sci.); (NU Singapore)

    2014-10-02

    Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.

  16. ppGpp couples transcription to DNA repair in E. coli.

    Science.gov (United States)

    Kamarthapu, Venu; Epshtein, Vitaly; Benjamin, Bradley; Proshkin, Sergey; Mironov, Alexander; Cashel, Michael; Nudler, Evgeny

    2016-05-20

    The small molecule alarmone (p)ppGpp mediates bacterial adaptation to nutrient deprivation by altering the initiation properties of RNA polymerase (RNAP). ppGpp is generated in Escherichia coli by two related enzymes, RelA and SpoT. We show that ppGpp is robustly, but transiently, induced in response to DNA damage and is required for efficient nucleotide excision DNA repair (NER). This explains why relA-spoT-deficient cells are sensitive to diverse genotoxic agents and ultraviolet radiation, whereas ppGpp induction renders them more resistant to such challenges. The mechanism of DNA protection by ppGpp involves promotion of UvrD-mediated RNAP backtracking. By rendering RNAP backtracking-prone, ppGpp couples transcription to DNA repair and prompts transitions between repair and recovery states.

  17. Recent functional insights into the role of (p)ppGpp in bacterial physiology.

    Science.gov (United States)

    Hauryliuk, Vasili; Atkinson, Gemma C; Murakami, Katsuhiko S; Tenson, Tanel; Gerdes, Kenn

    2015-05-01

    The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of (p)ppGpp metabolism and (p)ppGpp-mediated regulation. In this Review, we summarize these recent insights, with a focus on the molecular mechanisms governing the activity of the RelA/SpoT homologue (RSH) proteins, which are key players that regulate the cellular levels of (p)ppGpp. We also discuss the structural basis of transcriptional regulation by (p)ppGpp and the role of (p)ppGpp in GTP metabolism and in the emergence of bacterial persisters.

  18. PpIX induces mitochondria-related apoptosis in murine leukemia L1210 cells.

    Science.gov (United States)

    Su, Xiaomin; Chen, Yan; Wang, Xiaobing; Wang, Yuan; Wang, Pan; Li, Long; Liu, Quanhong

    2014-07-01

    Protoporphyrin IX (PpIX), a well-known sensitizer that can enhance laser light or ultrasound induced cytotoxicity in photodynamic and sonodynamic therapy. However, PpIX alone could effectively cause anti-tumor effect and the underlying mechanisms are rarely been reported. Therefore, this study was to investigate the possible mechanism by which PpIX revealed anti-proliferative effect on murine leukemia L1210 cells. The accumulation of PpIX in L1210 cells and normal peripheral blood mononuclear cells (PBMCs) was evaluated with flow cytometry. The subcellular localization of PpIX and apoptosis-inducing factor (AIF) translocation were determined by confocal microscope. The cell viability was examined by MTT assay. Annexin V-PE/7-AAD and DAPI staining were used to detect apoptotic cells. The mitochondrial membrane potential (MMP) changes were tested by rhodamine123 staining. DNA damage was measured by comet assay. PpIX preferentially accumulated in L1210 cells compared to PBMCs and PpIX mainly located in the mitochondria of L1210 cells. PpIX at a concentration of 1 µg/ml or above exerted significant anti-tumor effect and the cell viability loss presented PpIX dose-dependent manner. Typical apoptotic features such as chromatin condensation were observed by DAPI staining. Annexin V-PE/7-AAD analysis showed 5 µg/ml PpIX could induce about 24% cell apoptosis, which was inhibited by cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition pore. In addition, the PpIX caused MMP loss, AIF translocation to nucleus and serious DNA damage were also suppressed by CsA. The results indicate mitochondria-dependent apoptosis were involved in PpIX caused cell damage on L1210 cells.

  19. Multisource thermal model to the transverse momentum spectra in pp collisions at RHIC and LHC energies

    CERN Document Server

    Li, BC; Liu, F; Wen, XJ

    2016-01-01

    In an improved multisource thermal model, we systematically investigate the transverse momentum spectra in pp collisions at high energies ranging from 62.4 GeV to 7 TeV. The results are compared with the experimental data in RHIC and LHC. Based on the collision energy dependence of the source-excitation factors, we estimate the transverse momentum spectra in pp collisions at higher energies, potential future pp colliders operating at 33 and 100 TeV.

  20. Dilepton production in pp and CC collisions with HADES

    Energy Technology Data Exchange (ETDEWEB)

    Froehlich, I.; Heilmann, M.; Markert, J.; Muentz, C.; Pachmayer, Y.C.; Stroebele, H.; Teilab, K. [Johann Wolfgang Goethe-Universitaet, Institut fuer Kernphysik, Frankfurt (Germany); Agakishiev, G.; Destefanis, M.; Gilardi, C.; Kirschner, D.; Kuehn, W.; Metag, V.; Mishra, D.; Novotny, R.; Pechenov, V.; Pechenova, O.; Perez Cavalcanti, T.; Spruck, B.; Wen, H. [Justus Liebig Univ. Giessen, II.Physikalisches Inst., Giessen (Germany); Agodi, C.; Finocchiaro, P.; Spataro, S. [Istituto Nazionale di Fisica Nucleare, Lab. Nazionali del Sud, Catania (Italy); Balanda, A.; Kozuch, A.; Michalska, B.; Otwinowski, J.; Palka, M.; Przygoda, W.; Salabura, P.; Trebacz, R.; Wisniowski, M.; Wojcik, T. [Jagiellonian Univ. of Cracow, Smoluchowski Inst. of Physics, Cracow (Poland); Bellia, G. [Ist. Nazionale di Fisica Nucleare, Lab. Nazionali del Sud, Catania (Italy)]|[Univ. di Catania (Italy). Dipt. die Fisica e Astronomia; Belver, D.; Cabanelas, P.; Castro, E.; Garzon, J.A.; Lamas-Valverde, J.; Marin, J. [Univ. of Santiago de Compostela, Dept. de Fisica de Particulas, Santiago de Compostela (Spain); Belyaev, A.; Chernenko, S.; Fateev, O.; Ierusalimov, A.; Zanevsky, Y. [Joint Inst. of Nuclear Research, Dubna (Russian Federation); Blanco, A.; Lopes, L.; Mangiarotti, A. [LIP, Dept. de Fisica da Univ. de Coimbra, Coimbra (Portugal); Boehmer, M.; Christ, T.; Eberl, T.; Fabbietti, L.; Friese, J.; Gernhaeuser, R.; Jurkovic, M.; Kruecken, R.; Sailer, B. [Technische Univ. Muenchen, Physik Dept. E12, Garching (Germany); Boyard, J.L.; Hennino, T.; Moriniere, E.; Ramstein, B.; Roy-Stephan, M. [CNRS/IN2P3, Inst. de Physique Nucleaire d' Orsay, Orsay Cedex (France); Braun-Munzinger, P.; Galatyuk, T.; Gonzalez-Diaz, D.; Holzmann, R.; Koenig, I.; Koenig, W.; Kolb, B.W.; Lang, S.; Lange, S.; Pietraszko, J.; Rustamov, A.; Schmah, A.; Simon, R.; Sturm, C.; Traxler, M.; Zumbruch, P. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)] [and others

    2007-03-15

    e{sup +}e{sup -} production was studied using the High Acceptance DiElectron Spectrometer (HADES). In pp collisions at 2.2 GeV kinetic beam energy, the exclusive {eta} production and the Dalitz decay {eta}{yields}{gamma}e{sup +}e{sup -} have been reconstructed. The electromagnetic form factor of the latter decay was found to be in good agreement with the existing theoretical predictions. In addition, an inclusive e{sup +}e{sup -} invariant-mass spectrum from the {sup 12}C+{sup 12}C reaction at 2 AGeV is presented and compared with a simplified thermal model. (orig.)

  1. The Application of CP and PP in Business English

    Institute of Scientific and Technical Information of China (English)

    JIANG Lin; SUN Tian

    2015-01-01

    Cooperative principle and politeness principle enjoy great significance in pragmatic field.Via the analysis of certain ex⁃amples extracted from Business English course-book, this paper aims to study the observance of cooperative principle and polite⁃ness principle. The conclusion is reached that the application of CP and PP in pedagogical practice could benefit students ’lan⁃guage application. Meanwhile, this paper also aims to prove that cooperation and politeness are a key factor in communication through which teachers could improve students’language competence.

  2. Interpretation of the {\\Lambda}(1405) shift observed in pp collisions

    CERN Document Server

    Siebenson, Johannes

    2013-01-01

    In this work we investigate different possible explanations for the observed low mass {\\Lambda}(1405) signal associated to the production of the {\\Lambda}(1405) in p+p reactions at 3.5 GeV beam kinetic energy measured by the HADES collaboration. We study the influence of interference effects between the {\\Lambda}(1405) resonance and the non-resonant background. Furthermore, we present a phenomenological method to use the HADES data for determining the relative contribution of the two {\\Lambda}(1405) poles and discuss to which extent the data can constrain the position of these poles in the complex energy plane.

  3. Inclusive Jet Production in pp¯ Collisions

    Science.gov (United States)

    Abbott, B.; Abdesselam, A.; Abolins, M.; Abramov, V.; Acharya, B. S.; Adams, D. L.; Adams, M.; Alves, G. A.; Amos, N.; Anderson, E. W.; Baarmand, M. M.; Babintsev, V. V.; Babukhadia, L.; Bacon, T. C.; Baden, A.; Baldin, B.; Balm, P. W.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bauer, D.; Bean, A.; Begel, M.; Belyaev, A.; Beri, S. B.; Bernardi, G.; Bertram, I.; Besson, A.; Beuselinck, R.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Bhattacharjee, M.; Blazey, G.; Blessing, S.; Boehnlein, A.; Bojko, N. I.; Borcherding, F.; Brandt, A.; Breedon, R.; Briskin, G.; Brock, R.; Brooijmans, G.; Bross, A.; Buchholz, D.; Buehler, M.; Buescher, V.; Burtovoi, V. S.; Butler, J. M.; Canelli, F.; Carvalho, W.; Casey, D.; Casilum, Z.; Castilla-Valdez, H.; Chakraborty, D.; Chan, K. M.; Chekulaev, S. V.; Cho, D. K.; Choi, S.; Chopra, S.; Christenson, J. H.; Chung, M.; Claes, D.; Clark, A. R.; Cochran, J.; Coney, L.; Connolly, B.; Cooper, W. E.; Coppage, D.; Cummings, M. A.; Cutts, D.; Davis, G. A.; Davis, K.; de, K.; del Signore, K.; Demarteau, M.; Demina, R.; Demine, P.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; di Loreto, G.; Doulas, S.; Draper, P.; Ducros, Y.; Dudko, L. V.; Duensing, S.; Duflot, L.; Dugad, S. R.; Dyshkant, A.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Engelmann, R.; Eno, S.; Eppley, G.; Ermolov, P.; Eroshin, O. V.; Estrada, J.; Evans, H.; Evdokimov, V. N.; Fahland, T.; Feher, S.; Fein, D.; Ferbel, T.; Fisk, H. E.; Fisyak, Y.; Flattum, E.; Fleuret, F.; Fortner, M.; Frame, K. C.; Fuess, S.; Gallas, E.; Galyaev, A. N.; Gao, M.; Gavrilov, V.; Genik, R. J.; Genser, K.; Gerber, C. E.; Gershtein, Y.; Gilmartin, R.; Ginther, G.; Gómez, B.; Gómez, G.; Goncharov, P. I.; González Solís, J. L.; Gordon, H.; Goss, L. T.; Gounder, K.; Goussiou, A.; Graf, N.; Graham, G.; Grannis, P. D.; Green, J. A.; Greenlee, H.; Grinstein, S.; Groer, L.; Grünendahl, S.; Gupta, A.; Gurzhiev, S. N.; Gutierrez, G.; Gutierrez, P.; Hadley, N. J.; Haggerty, H.; Hagopian, S.; Hagopian, V.; Hahn, K. S.; Hall, R. E.; Hanlet, P.; Hansen, S.; Hauptman, J. M.; Hays, C.; Hebert, C.; Hedin, D.; Heinson, A. P.; Heintz, U.; Heuring, T.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hoftun, J. S.; Hou, S.; Huang, Y.; Illingworth, R.; Ito, A. S.; Jaffré, M.; Jerger, S. A.; Jesik, R.; Johns, K.; Johnson, M.; Jonckheere, A.; Jones, M.; Jöstlein, H.; Juste, A.; Kahn, S.; Kajfasz, E.; Karmanov, D.; Karmgard, D.; Kim, S. K.; Klima, B.; Klopfenstein, C.; Knuteson, B.; Ko, W.; Kohli, J. M.; Kostritskiy, A. V.; Kotcher, J.; Kotwal, A. V.; Kozelov, A. V.; Kozlovsky, E. A.; Krane, J.; Krishnaswamy, M. R.; Krzywdzinski, S.; Kubantsev, M.; Kuleshov, S.; Kulik, Y.; Kunori, S.; Kuznetsov, V. E.; Landsberg, G.; Leflat, A.; Leggett, C.; Lehner, F.; Li, J.; Li, Q. Z.; Lima, J. G.; Lincoln, D.; Linn, S. L.; Linnemann, J.; Lipton, R.; Lucotte, A.; Lueking, L.; Lundstedt, C.; Luo, C.; Maciel, A. K.; Madaras, R. J.; Manankov, V.; Mao, H. S.; Marshall, T.; Martin, M. I.; Martin, R. D.; Mauritz, K. M.; May, B.; Mayorov, A. A.; McCarthy, R.; McDonald, J.; McMahon, T.; Melanson, H. L.; Meng, X. C.; Merkin, M.; Merritt, K. W.; Miao, C.; Miettinen, H.; Mihalcea, D.; Mishra, C. S.; Mokhov, N.; Mondal, N. K.; Montgomery, H. E.; Moore, R. W.; Mostafa, M.; da Motta, H.; Nagy, E.; Nang, F.; Narain, M.; Narasimham, V. S.; Neal, H. A.; Negret, J. P.; Negroni, S.; Norman, D.; Nunnemann, T.; Oesch, L.; Oguri, V.; Olivier, B.; Oshima, N.; Padley, P.; Pan, L. J.; Papageorgiou, K.; Para, A.; Parashar, N.; Partridge, R.; Parua, N.; Paterno, M.; Patwa, A.; Pawlik, B.; Perkins, J.; Peters, M.; Peters, O.; Pétroff, P.; Piegaia, R.; Piekarz, H.; Pope, B. G.; Popkov, E.; Prosper, H. B.; Protopopescu, S.; Qian, J.; Quintas, P. Z.; Raja, R.; Rajagopalan, S.; Ramberg, E.; Rapidis, P. A.; Reay, N. W.; Reucroft, S.; Rha, J.; Ridel, M.; Rijssenbeek, M.; Rockwell, T.; Roco, M.; Rubinov, P.; Ruchti, R.; Rutherfoord, J.; Santoro, A.; Sawyer, L.; Schamberger, R. D.; Schellman, H.; Schwartzman, A.; Sen, N.; Shabalina, E.; Shivpuri, R. K.; Shpakov, D.; Shupe, M.; Sidwell, R. A.; Simak, V.; Singh, H.; Singh, J. B.; Sirotenko, V.; Slattery, P.; Smith, E.; Smith, R. P.; Snihur, R.; Snow, G. R.; Snow, J.; Snyder, S.; Solomon, J.; Sorín, V.; Sosebee, M.; Sotnikova, N.; Soustruznik, K.; Souza, M.; Stanton, N. R.; Steinbrück, G.; Stephens, R. W.; Stichelbaut, F.; Stoker, D.; Stolin, V.; Stoyanova, D. A.; Strauss, M.; Strovink, M.; Stutte, L.; Sznajder, A.; Taylor, W.; Tentindo-Repond, S.; Thompson, J.; Toback, D.; Tripathi, S. M.; Trippe, T. G.; Turcot, A. S.; Tuts, P. M.; van Gemmeren, P.; Vaniev, V.; van Kooten, R.; Varelas, N.; Volkov, A. A.; Vorobiev, A. P.; Wahl, H. D.; Wang, H.; Wang, Z.-M.; Warchol, J.; Watts, G.; Wayne, M.; Weerts, H.; White, A.; White, J. T.; Whiteson, D.; Wightman, J. A.; Wijngaarden, D. A.; Willis, S.; Wimpenny, S. J.; Wirjawan, J. V.; Womersley, J.; Wood, D. R.; Yamada, R.; Yamin, P.; Yasuda, T.; Yip, K.; Youssef, S.; Yu, J.; Yu, Z.; Zanabria, M.; Zheng, H.; Zhou, Z.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zutshi, V.; Zverev, E. G.; Zylberstejn, A.

    2001-02-01

    We report a new measurement of the pseudorapidity ( η) and transverse-energy ( ET) dependence of the inclusive jet production cross section in pp¯ collisions at s = 1.8 TeV using 95 pb-1 of data collected with the D0 detector at the Fermilab Tevatron. The differential cross section d2σ/\\(dETdη\\) is presented up to \\|η\\| = 3, significantly extending previous measurements. The results are in good overall agreement with next-to-leading order predictions from QCD and indicate a preference for certain parton distribution functions.

  4. Flavour tagging of $b$ mesons in $pp$ collisions at LHCb

    CERN Multimedia

    Mueller, Vanessa

    2016-01-01

    Flavour tagging, i.e. the inference of the production flavour of reconstructed $b$ hadrons, is essential for precision measurements of decay time-dependent $CP$ violation and of mixing parameters in the the neutral $B$ meson systems. LHC's $pp$ collisions with their high track multiplicities constitute a challenging environment for flavour tagging and demand for new and improved strategies. We present recent progress and new developments in flavour tagging at the LHCb experiment, which will allow for a further improvement of $CP$ violation measurements in decays of $B^0$ and $B_s^0$ mesons.

  5. Unintegrated gluon distribution and soft pp collisions at LHC

    CERN Document Server

    Grinyuk, A A; Lykasov, G I; Lipatov, A V; Zotov, N P

    2012-01-01

    We found the parameterization of the unintegrated gluon distribution from the best description of the LHC data on the inclusive spectra of hadrons produced in $pp$ collisions at the mid-rapidity region and small transverse momenta. It is different from the one obtained within perturbative QCD only at low intrinsic transverse momenta $k_t$. The application of this distribution to analysis of the $e-p$ DIS allows us to get the results which do not contradict the H1 and ZEUS data on the structure functions at low $x$. So, the connection between the soft processes at LHC and low-$x$ physics at HERA is found.

  6. Gamma radiation induced degradation in PE-PP block copolymer

    Energy Technology Data Exchange (ETDEWEB)

    Ravi, H. R.; Sreepad, H. R.; Ahmed, Khaleel; Govindaiah, T. N. [P.G. Department of Physics, Government College (Autonomous), Mandya - 571401, Karnataka State (India)

    2012-06-05

    In the present investigation, effect of gamma irradiation on the PP-PE block copolymer has been studied. The polymer has been subjected to gamma irradiation from 100 to 500 Mrad dosages. Characterization of the polymer using XRD and FTIR was done both before irradiation and after irradiation in each step. Effect of irradiation on the electrical properties of the material has also been studied. FTIR study shows that the sample loses C - C stretching mode of vibration but gains C=C stretching mode of vibration after irradiation. Present investigation clearly indicates that though the electrical conductivity increases in the material, it undergoes degradation and shows brittleness due to irradiation.

  7. RHIC FY15 pp Run RHIC and AGS polarization analysis

    Energy Technology Data Exchange (ETDEWEB)

    Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Adams, P. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-02-20

    The polarization information is important for the spin physics program in Relativistic Heavy Ion Collider (RHIC). There are discrepancies between AGS and RHIC polarization measurements. First, the face value of AGS polarization is higher than RHIC ones in general. Second, the measured polarization profile (described by the profile ratio R) is stronger in AGS than in RHIC. This note analyzes the polarization data from FY15 pp run period. The results show that the differences between AGS and RHIC polarization measurements are reasonable, but the R value difference is puzzling. The difference between blue and yellow ring is worth of spin simulation to explain.

  8. The GridPP DIRAC project: Implementation of a multi-VO DIRAC service

    Science.gov (United States)

    Bauer, D.; Colling, D.; Currie, R.; Fayer, S.; Huffman, A.; Martyniak, J.; Rand, D.; Richards, A.

    2015-12-01

    The GridPP consortium provides computing support to many high energy physics projects in the UK. As part of this GridPP offers access to a large amount of highly distributed resources across the UK for multiple collaborations. The userbase supported by GridPP includes hundreds of users spanning multiple virtual organisations with many different computing requirements. In order to provide a common interface to these distributed a centralised DIRAC instance has been setup at Imperial College London. This paper describes the experiences learnt from deploying this DIRAC instance and the modifications that have made to support the GridPP use case.

  9. ToF-SIMS imaging of PE/PP polymer using multivariate analysis

    Science.gov (United States)

    Miyasaka, Toyomitsu; Ikemoto, Takashi; Kohno, Teiichiro

    2008-12-01

    The distribution of polyethylene (PE) and polypropylene (PP) in PE/PP blended-polymer film was determined by applying principal components analysis (PCA) and multivariate curve resolution (MCR) to time-of-flight secondary ion mass spectroscopy (ToF-SIMS) imaging, together with preprocessing by pixel binning, normalization, and autoscaling to increase image contrast by reducing topographic and charge-distribution effects. The PE/PP distribution was confirmed by MVA conducted on the image data over static limit. The MCR score with normalized-autoscaling was found to give the PE/PP distribution distinctly.

  10. Preparation,structure and properties of PP-g-AA grafting copolymer

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Polypropylene grafting with AA was prepared by reactive extrusion with pre-irradiated PP (rPP) as the homogeneous initiator.The effects of the pre-irradiated dose,the fraction of rPP and the concentration of acrylic acid on the grafting reaction were studied and the grafted PP was characterized by Fourier transition infrared spectroscopy (FTIR),differential scanning calorimeter (DSC)and polarized light microscopy (PLM).The results show that the degradation of PP was suppressed efficiently with this novel method for preparing PP-g-AA copolymers,and the grafted copolymers with good mechanical properties were obtained.It was found that the product with higher graft degree (Gd)(0.19%) and relatively excellent mechanical properties can be produced if the mass ratio of PP/rPP/AA 4 kGy.Moreover,an adhesive strength of 4.88 kN/m was reached in the PP-g-AA/aluminum laminate.

  11. Mechanical and thermal properties of polypropylene (PP) composites filled with modified shell waste

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Z.T., E-mail: sxyzt@126.com [College of Materials Science and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018 (China); Chen, T. [Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058 (China); Li, H.Y. [Zhoushan Ocean Research Institute, Zhejiang University, Zhoushan 316021 (China); Xia, M.S., E-mail: msxia@zju.edu.cn [Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058 (China); Ye, Y.; Zheng, H. [Department of Ocean Science and Engineering, Zhejiang University, Hangzhou 310058 (China)

    2013-11-15

    Highlights: • Adding modified shell powder could significantly increase the properties of PP. • The modified shell powder could act as a nucleating agent in PP matrix. • The modified shell powder has a potential to be used as a bio-filler. -- Abstract: Shell waste, with its high content of calcium carbonate (CaCO{sub 3}) plus organic matrix, has a potential to be used as a bio-filler. In this work, shell waste was modified by furfural and then incorporated to reinforce polypropylene (PP). The shell waste and modified powder were characterized by means of X-ray diffraction (XRD), scanning electron microscopy equipped with an energy dispersive spectrometer (SEM-EDS), X-ray photoelectronic spectroscopy (XPS), and Fourier transformed infrared spectroscopy (FTIR). The mechanical and thermal properties of neat PP and PP composites were investigated as well. Thermal gravimetric (TG) analyses confirmed the reinforcing role of modified powder in PP composites. The mechanical properties studied showed that adding modified powder could significantly increase the impact strength, elongation at break point and flexural modulus of composites. The maximum incorporation content could reach 15 wt.% with a good balance between toughness and stiffness of PP composites. Differential scanning calorimetry (DSC) results showed that the modified powder could act as a nucleating agent and thus increase the crystallization temperature of PP. Polarized optical microscopy (POM) observation also indicated that the introduction of modified powder could promote the heterogeneous nucleation of PP matrix.

  12. Differential regulation by ppGpp versus pppGpp in Escherichia coli.

    Science.gov (United States)

    Mechold, Undine; Potrykus, Katarzyna; Murphy, Helen; Murakami, Katsuhiko S; Cashel, Michael

    2013-07-01

    Both ppGpp and pppGpp are thought to function collectively as second messengers for many complex cellular responses to nutritional stress throughout biology. There are few indications that their regulatory effects might be different; however, this question has been largely unexplored for lack of an ability to experimentally manipulate the relative abundance of ppGpp and pppGpp. Here, we achieve preferential accumulation of either ppGpp or pppGpp with Escherichia coli strains through induction of different Streptococcal (p)ppGpp synthetase fragments. In addition, expression of E. coli GppA, a pppGpp 5'-gamma phosphate hydrolase that converts pppGpp to ppGpp, is manipulated to fine tune differential accumulation of ppGpp and pppGpp. In vivo and in vitro experiments show that pppGpp is less potent than ppGpp with respect to regulation of growth rate, RNA/DNA ratios, ribosomal RNA P1 promoter transcription inhibition, threonine operon promoter activation and RpoS induction. To provide further insights into regulation by (p)ppGpp, we have also determined crystal structures of E. coli RNA polymerase-σ(70) holoenzyme with ppGpp and pppGpp. We find that both nucleotides bind to a site at the interface between β' and ω subunits.

  13. Different effects of ppGpp on Escherichia coli DNA replication in vivo and in vitro.

    Science.gov (United States)

    Maciąg-Dorszyńska, Monika; Szalewska-Pałasz, Agnieszka; Węgrzyn, Grzegorz

    2013-01-01

    Inhibition of Escherichia coli DNA replication by guanosine tetraphosphate (ppGpp) is demonstrated in vitro. This finding is compatible with impairment of the DnaG primase activity by this nucleotide. However, in agreement to previous reports, we were not able to detect a rapid inhibition of DNA synthesis in E. coli cells under the stringent control conditions, when intracellular ppGpp levels increase dramatically. We suggest that the process of ppGpp-mediated inhibition of DnaG activity may be masked in E. coli cells, which could provide a rationale for explanation of differences between ppGpp effects on DNA replication in E. coli and Bacillus subtilis.

  14. Study on Properties of PP/Nano-CaCO3 Composite%PP/Nano-CaCO3复合材料性能的研究

    Institute of Scientific and Technical Information of China (English)

    高岩磊; 陈慧; 郧海丽; 崔文广

    2012-01-01

    PP/nano-CaCO3 composite was prepared by melt blending PP with nano-CaCO3. The effect of the nano-CaCO3 content on mechanical property of the PP/nano-CaC03 composite was studied. The dispersion of the nano-CaCO3 in PP matrix was analyzed by SEM. The results show that: with the increase of content of nano-CaCO3, the impact strength and the tensile strength of the PP/nano-CaCO3 composite both increase firstly and then decrease, but the flexural modulus of the PP/nano-CaCO3 composite increase evidently. The dispersion of the nano-CaCO3 in PP matrix gradually becomes bad with the increase of the content of nano-CaCO3.%采用熔融共混法制备出了聚丙烯(PP)/纳米碳酸钙(nano-CaCO3)复合材料,研究了nano-CaCO3的加入量对复合材料力学性能的影响,利用扫描电镜(SEM)分析了nano-CaCO3在PP基体中的分散性.结果表明:随着nano-CaCO3用量的增加,PP/nano-CaCO3复合材料的冲击强度和拉伸强度均呈现出先增加后降低的趋势,而弯曲模量呈增加趋势;随着填加最的增加,nano-CaCO3在PP基体中的分散性逐渐变差.

  15. Measurement of the Slope Parameter for the eta->3pi0 Decay in the pp->pp eta Reaction

    CERN Document Server

    Bashkanov, M; Calén, H; Capellaro, F; Clement, H; Demirörs, L; Ekström, C; Fransson, K; Gustafsson, L; Höistad, B; Ivanov, G; Jacewicz, M; Jiganov, E; Johansson, T; Keleta, S; Koch, I; Kullander, Sven; Kupsc, A; Kuznetsov, A; Marciniewski, P; Meier, R; Morosov, B; Oelert, W; Pauly, C; Petukhov, Yu P; Pettersson, H; Povtorejko, A; Ruber, R J M Y; Schönning, K; Scobel, W; Skorodko, T; Shwartz, B; Sopov, V; Stepaniak, J; Chernyshov, V; Engblom, P Thörngren; Tikhomirov, V; Turowiecki, A; Wagner, G J; Wiedner, U; Wolke, M; Yamamoto, A; Zabierowski, J; Złomańczuk, J

    2007-01-01

    The CELSIUS/WASA setup is used to measure the 3pi0 decay of eta mesons produced in pp interactions with beam kinetic energies of 1.36 and 1.45 GeV. The efficiency-corrected Dalitz plot and density distributions for this decay are shown, together with a fit of the quadratic slope parameter alpha yielding alpha = -0.026 +/- 0.010(stat) +/- 0.010(syst). This value is compared to recent experimental results and theoretical predictions.

  16. Evidence for collectivity in pp collisions at the LHC

    CERN Document Server

    Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; König, Axel; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rad, Navid; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; De Wolf, Eddi A; Janssen, Xavier; Lauwers, Jasper; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Lowette, Steven; Moortgat, Seth; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Parijs, Isis; Brun, Hugues; Caillol, Cécile; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Goldouzian, Reza; Grebenyuk, Anastasia; Karapostoli, Georgia; Lenzi, Thomas; Léonard, Alexandre; Luetic, Jelena; Maerschalk, Thierry; Marinov, Andrey; Randle-conde, Aidan; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Cimmino, Anna; Cornelis, Tom; Dobur, Didar; Fagot, Alexis; Garcia, Guillaume; Gul, Muhammad; Poyraz, Deniz; Salva Diblen, Sinem; Schöfbeck, Robert; Sharma, Archana; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Bakhshiansohi, Hamed; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Caudron, Adrien; De Visscher, Simon; Delaere, Christophe; Delcourt, Martin; Francois, Brieuc; Giammanco, Andrea; Jafari, Abideh; Jez, Pavel; Komm, Matthias; Lemaitre, Vincent; Magitteri, Alessio; Mertens, Alexandre; Musich, Marco; Nuttens, Claude; Piotrzkowski, Krzysztof; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Wertz, Sébastien; Beliy, Nikita; Aldá Júnior, Walter Luiz; Alves, Fábio Lúcio; Alves, Gilvan; Brito, Lucas; Hensel, Carsten; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Melo Da Costa, Eliza; Da Silveira, Gustavo Gil; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mora Herrera, Clemencia; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Fang, Wenxing; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Chen, Ye; Cheng, Tongguang; Jiang, Chun-Hua; Leggat, Duncan; Liu, Zhenan; Romeo, Francesco; Shaheen, Sarmad Masood; Spiezia, Aniello; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Zhao, Jingzhou; Ban, Yong; Chen, Geng; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; González Hernández, Carlos Felipe; Ruiz Alvarez, José David; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Sculac, Toni; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Ferencek, Dinko; Kadija, Kreso; Micanovic, Sasa; Sudic, Lucija; Susa, Tatjana; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Finger, Miroslav; Finger Jr, Michael; Carrera Jarrin, Edgar; Abdelalim, Ahmed Ali; El-khateeb, Esraa; Salama, Elsayed; Calpas, Betty; Kadastik, Mario; Murumaa, Marion; Perrini, Lucia; Raidal, Martti; Tiko, Andres; Veelken, Christian; Eerola, Paula; Pekkanen, Juska; Voutilainen, Mikko; Härkönen, Jaakko; Karimäki, Veikko; Kinnunen, Ritva; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Talvitie, Joonas; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Ghosh, Saranya; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Kucher, Inna; Locci, Elizabeth; Machet, Martina; Malcles, Julie; Rander, John; Rosowsky, André; Titov, Maksym; Zghiche, Amina; Abdulsalam, Abdulla; Antropov, Iurii; Baffioni, Stephanie; Beaudette, Florian; Busson, Philippe; Cadamuro, Luca; Chapon, Emilien; Charlot, Claude; Davignon, Olivier; Granier de Cassagnac, Raphael; Jo, Mihee; Lisniak, Stanislav; Miné, Philippe; Nguyen, Matthew; Ochando, Christophe; Ortona, Giacomo; Paganini, Pascal; Pigard, Philipp; Regnard, Simon; Salerno, Roberto; Sirois, Yves; Strebler, Thomas; Yilmaz, Yetkin; Zabi, Alexandre; Agram, Jean-Laurent; Andrea, Jeremy; Aubin, Alexandre; Bloch, Daniel; Brom, Jean-Marie; Buttignol, Michael; Chabert, Eric Christian; Chanon, Nicolas; Collard, Caroline; Conte, Eric; Coubez, Xavier; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Le Bihan, Anne-Catherine; Skovpen, Kirill; Van Hove, Pierre; Gadrat, Sébastien; Beauceron, Stephanie; Bernet, Colin; Boudoul, Gaelle; Bouvier, Elvire; Carrillo Montoya, Camilo Andres; Chierici, Roberto; Contardo, Didier; Courbon, Benoit; Depasse, Pierre; El Mamouni, Houmani; Fan, Jiawei; Fay, Jean; Gascon, Susan; Gouzevitch, Maxime; Grenier, Gérald; Ille, Bernard; Lagarde, Francois; Laktineh, Imad Baptiste; Lethuillier, Morgan; Mirabito, Laurent; Pequegnot, Anne-Laure; Perries, Stephane; Popov, Andrey; Sabes, David; Sordini, Viola; Vander Donckt, Muriel; Verdier, Patrice; Viret, Sébastien; Toriashvili, Tengizi; Tsamalaidze, Zviad; Autermann, Christian; Beranek, Sarah; Feld, Lutz; Heister, Arno; Kiesel, Maximilian Knut; Klein, Katja; Lipinski, Martin; Ostapchuk, Andrey; Preuten, Marius; Raupach, Frank; Schael, Stefan; Schomakers, Christian; Schulte, Jan-Frederik; Schulz, Johannes; Verlage, Tobias; Weber, Hendrik; Zhukov, Valery; Albert, Andreas; Brodski, Michael; Dietz-Laursonn, Erik; Duchardt, Deborah; Endres, Matthias; Erdmann, Martin; Erdweg, Sören; Esch, Thomas; Fischer, Robert; Güth, Andreas; Hamer, Matthias; Hebbeker, Thomas; Heidemann, Carsten; Hoepfner, Kerstin; Knutzen, Simon; Merschmeyer, Markus; Meyer, Arnd; Millet, Philipp; Mukherjee, Swagata; Olschewski, Mark; Padeken, Klaas; Pook, Tobias; Radziej, Markus; Reithler, Hans; Rieger, Marcel; Scheuch, Florian; Sonnenschein, Lars; Teyssier, Daniel; Thüer, Sebastian; Cherepanov, Vladimir; Flügge, Günter; Haj Ahmad, Wael; Hoehle, Felix; Kargoll, Bastian; Kress, Thomas; Künsken, Andreas; Lingemann, Joschka; Müller, Thomas; Nehrkorn, Alexander; Nowack, Andreas; Nugent, Ian Michael; Pistone, Claudia; Pooth, Oliver; Stahl, Achim; Aldaya Martin, Maria; Asawatangtrakuldee, Chayanit; Beernaert, Kelly; Behnke, Olaf; Behrens, Ulf; Bin Anuar, Afiq Aizuddin; Borras, Kerstin; Campbell, Alan; Connor, Patrick; Contreras-Campana, Christian; Costanza, Francesco; Diez Pardos, Carmen; Dolinska, Ganna; Eckerlin, Guenter; Eckstein, Doris; Eren, Engin; Gallo, Elisabetta; Garay Garcia, Jasone; Geiser, Achim; Gizhko, Andrii; Grados Luyando, Juan Manuel; Gunnellini, Paolo; Harb, Ali; Hauk, Johannes; Hempel, Maria; Jung, Hannes; Kalogeropoulos, Alexis; Karacheban, Olena; Kasemann, Matthias; Keaveney, James; Kleinwort, Claus; Korol, Ievgen; Krücker, Dirk; Lange, Wolfgang; Lelek, Aleksandra; Leonard, Jessica; Lipka, Katerina; Lobanov, Artur; Lohmann, Wolfgang; Mankel, Rainer; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mittag, Gregor; Mnich, Joachim; Mussgiller, Andreas; Ntomari, Eleni; Pitzl, Daniel; Raspereza, Alexei; Roland, Benoit; Sahin, Mehmet Özgür; Saxena, Pooja; Schoerner-Sadenius, Thomas; Seitz, Claudia; Spannagel, Simon; Stefaniuk, Nazar; Van Onsem, Gerrit Patrick; Walsh, Roberval; Wissing, Christoph; Blobel, Volker; Centis Vignali, Matteo; Draeger, Arne-Rasmus; Dreyer, Torben; Garutti, Erika; Gonzalez, Daniel; Haller, Johannes; Hoffmann, Malte; Junkes, Alexandra; Klanner, Robert; Kogler, Roman; Kovalchuk, Nataliia; Lapsien, Tobias; Lenz, Teresa; Marchesini, Ivan; Marconi, Daniele; Meyer, Mareike; Niedziela, Marek; Nowatschin, Dominik; Pantaleo, Felice; Peiffer, Thomas; Perieanu, Adrian; Poehlsen, Jennifer; Sander, Christian; Scharf, Christian; Schleper, Peter; Schmidt, Alexander; Schumann, Svenja; Schwandt, Joern; Stadie, Hartmut; Steinbrück, Georg; Stober, Fred-Markus Helmut; Stöver, Marc; Tholen, Heiner; Troendle, Daniel; Usai, Emanuele; Vanelderen, Lukas; Vanhoefer, Annika; Vormwald, Benedikt; Barth, Christian; Baus, Colin; Berger, Joram; Butz, Erik; Chwalek, Thorsten; Colombo, Fabio; De Boer, Wim; Dierlamm, Alexander; Fink, Simon; Friese, Raphael; Giffels, Manuel; Gilbert, Andrew; Goldenzweig, Pablo; Haitz, Dominik; Hartmann, Frank; Heindl, Stefan Michael; Husemann, Ulrich; Katkov, Igor; Lobelle Pardo, Patricia; Maier, Benedikt; Mildner, Hannes; Mozer, Matthias Ulrich; Müller, Thomas; Plagge, Michael; Quast, Gunter; Rabbertz, Klaus; Röcker, Steffen; Roscher, Frank; Schröder, Matthias; Shvetsov, Ivan; Sieber, Georg; Simonis, Hans-Jürgen; Ulrich, Ralf; Wagner-Kuhr, Jeannine; Wayand, Stefan; Weber, Marc; Weiler, Thomas; Williamson, Shawn; Wöhrmann, Clemens; Wolf, Roger; Anagnostou, Georgios; Daskalakis, Georgios; Geralis, Theodoros; Giakoumopoulou, Viktoria Athina; Kyriakis, Aristotelis; Loukas, Demetrios; Topsis-Giotis, Iasonas; Kesisoglou, Stilianos; Panagiotou, Apostolos; Saoulidou, Niki; Tziaferi, Eirini; Evangelou, Ioannis; Flouris, Giannis; Foudas, Costas; Kokkas, Panagiotis; Loukas, Nikitas; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Filipovic, Nicolas; Bencze, Gyorgy; Hajdu, Csaba; Hidas, Pàl; Horvath, Dezso; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Zsigmond, Anna Julia; Beni, Noemi; Czellar, Sandor; Karancsi, János; Makovec, Alajos; Molnar, Jozsef; Szillasi, Zoltan; Bartók, Márton; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Bahinipati, Seema; Choudhury, Somnath; Mal, Prolay; Mandal, Koushik; Nayak, Aruna; Sahoo, Deepak Kumar; Sahoo, Niladribihari; Swain, Sanjay Kumar; Bansal, Sunil; Beri, Suman Bala; Bhatnagar, Vipin; Chawla, Ridhi; Bhawandeep, Bhawandeep; Kalsi, Amandeep Kaur; Kaur, Anterpreet; Kaur, Manjit; Kumar, Ramandeep; Mehta, Ankita; Mittal, Monika; Singh, Jasbir; Walia, Genius; Kumar, Ashok; Bhardwaj, Ashutosh; Choudhary, Brajesh C; Garg, Rocky Bala; Keshri, Sumit; Malhotra, Shivali; Naimuddin, Md; Nishu, Nishu; Ranjan, Kirti; Sharma, Ramkrishna; Sharma, Varun; Bhattacharya, Rajarshi; Bhattacharya, Satyaki; Chatterjee, Kalyanmoy; Dey, Sourav; Dutt, Suneel; Dutta, Suchandra; Ghosh, Shamik; Majumdar, Nayana; Modak, Atanu; Mondal, Kuntal; Mukhopadhyay, Supratik; Nandan, Saswati; Purohit, Arnab; Roy, Ashim; Roy, Debarati; Roy Chowdhury, Suvankar; Sarkar, Subir; Sharan, Manoj; Thakur, Shalini; Behera, Prafulla Kumar; Chudasama, Ruchi; Dutta, Dipanwita; Jha, Vishwajeet; Kumar, Vineet; Mohanty, Ajit Kumar; Netrakanti, Pawan Kumar; Pant, Lalit Mohan; Shukla, Prashant; Topkar, Anita; Aziz, Tariq; Dugad, Shashikant; Kole, Gouranga; Mahakud, Bibhuprasad; Mitra, Soureek; Mohanty, Gagan Bihari; Parida, Bibhuti; Sur, Nairit; Sutar, Bajrang; Banerjee, Sudeshna; Bhowmik, Sandeep; Dewanjee, Ram Krishna; Ganguly, Sanmay; Guchait, Monoranjan; Jain, Sandhya; Kumar, Sanjeev; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Sarkar, Tanmay; Wickramage, Nadeesha; Chauhan, Shubhanshu; Dube, Sourabh; Hegde, Vinay; Kapoor, Anshul; Kothekar, Kunal; Rane, Aditee; Sharma, Seema; Behnamian, Hadi; Chenarani, Shirin; Eskandari Tadavani, Esmaeel; Etesami, Seyed Mohsen; Fahim, Ali; Khakzad, Mohsen; Mohammadi Najafabadi, Mojtaba; Naseri, Mohsen; Paktinat Mehdiabadi, Saeid; Rezaei Hosseinabadi, Ferdos; Safarzadeh, Batool; Zeinali, Maryam; Felcini, Marta; Grunewald, Martin; Abbrescia, Marcello; Calabria, Cesare; Caputo, Claudio; Colaleo, Anna; Creanza, Donato; Cristella, Leonardo; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Maggi, Giorgio; Maggi, Marcello; Miniello, Giorgia; My, Salvatore; Nuzzo, Salvatore; Pompili, Alexis; Pugliese, Gabriella; Radogna, Raffaella; Ranieri, Antonio; Selvaggi, Giovanna; Silvestris, Lucia; Venditti, Rosamaria; Verwilligen, Piet; Abbiendi, Giovanni; Battilana, Carlo; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Campanini, Renato; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Chhibra, Simranjit Singh; Codispoti, Giuseppe; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Guiducci, Luigi; Marcellini, Stefano; Masetti, Gianni; Montanari, Alessandro; Navarria, Francesco; Perrotta, Andrea; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gian Piero; Tosi, Nicolò; Albergo, Sebastiano; Chiorboli, Massimiliano; Costa, Salvatore; Di Mattia, Alessandro; Giordano, Ferdinando; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Gori, Valentina; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Viliani, Lorenzo; Benussi, Luigi; Bianco, Stefano; Fabbri, Franco; Piccolo, Davide; Primavera, Federica; Calvelli, Valerio; Ferro, Fabrizio; Lo Vetere, Maurizio; Monge, Maria Roberta; Robutti, Enrico; Tosi, Silvano; Brianza, Luca; Dinardo, Mauro Emanuele; Fiorendi, Sara; Gennai, Simone; Ghezzi, Alessio; Govoni, Pietro; Malberti, Martina; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Marzocchi, Badder; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Pigazzini, Simone; Ragazzi, Stefano; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Cavallo, Nicola; De Nardo, Guglielmo; Di Guida, Salvatore; Esposito, Marco; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lanza, Giuseppe; Lista, Luca; Meola, Sabino; Paolucci, Pierluigi; Sciacca, Crisostomo; Thyssen, Filip; Azzi, Patrizia; Bacchetta, Nicola; Benato, Lisa; Bisello, Dario; Boletti, Alessio; Carlin, Roberto; Carvalho Antunes De Oliveira, Alexandra; Checchia, Paolo; Dall'Osso, Martino; De Castro Manzano, Pablo; Dorigo, Tommaso; Dosselli, Umberto; Gasparini, Fabrizio; Gasparini, Ugo; Gozzelino, Andrea; Lacaprara, Stefano; Margoni, Martino; Meneguzzo, Anna Teresa; Pazzini, Jacopo; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Zanetti, Marco; Zotto, Pierluigi; Zucchetta, Alberto; Zumerle, Gianni; Braghieri, Alessandro; Magnani, Alice; Montagna, Paolo; Ratti, Sergio P; Re, Valerio; Riccardi, Cristina; Salvini, Paola; Vai, Ilaria; Vitulo, Paolo; Alunni Solestizi, Luisa; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Leonardi, Roberto; Mantovani, Giancarlo; Menichelli, Mauro; Saha, Anirban; Santocchia, Attilio; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Donato, Silvio; Fedi, Giacomo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Cipriani, Marco; D'imperio, Giulia; Del Re, Daniele; Diemoz, Marcella; Gelli, Simone; Longo, Egidio; Margaroli, Fabrizio; Meridiani, Paolo; Organtini, Giovanni; Paramatti, Riccardo; Preiato, Federico; Rahatlou, Shahram; Rovelli, Chiara; Santanastasio, Francesco; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Bartosik, Nazar; Bellan, Riccardo; Biino, Cristina; Cartiglia, Nicolo; Cenna, Francesca; Costa, Marco; Covarelli, Roberto; Degano, Alessandro; Demaria, Natale; Finco, Linda; Kiani, Bilal; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Monteil, Ennio; Obertino, Maria Margherita; Pacher, Luca; Pastrone, Nadia; Pelliccioni, Mario; Pinna Angioni, Gian Luca; Ravera, Fabio; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Shchelina, Ksenia; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Traczyk, Piotr; Belforte, Stefano; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; La Licata, Chiara; Schizzi, Andrea; Zanetti, Anna; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Lee, Sangeun; Lee, Seh Wook; Oh, Young Do; Sekmen, Sezen; Son, Dong-Chul; Yang, Yu Chul; Lee, Ari; Kim, Hyunchul; Brochero Cifuentes, Javier Andres; Kim, Tae Jeong; Cho, Sungwoong; Choi, Suyong; Go, Yeonju; Gyun, Dooyeon; Ha, Seungkyu; Hong, Byung-Sik; Jo, Youngkwon; Kim, Yongsun; Lee, Byounghoon; Lee, Kisoo; Lee, Kyong Sei; Lee, Songkyo; Lim, Jaehoon; Park, Sung Keun; Roh, Youn; Almond, John; Kim, Junho; Lee, Haneol; Oh, Sung Bin; Radburn-Smith, Benjamin Charles; Seo, Seon-hee; Yang, Unki; Yoo, Hwi Dong; Yu, Geum Bong; Choi, Minkyoo; Kim, Hyunyong; Kim, Ji Hyun; Lee, Jason Sang Hun; Park, Inkyu; Ryu, Geonmo; Ryu, Min Sang; Choi, Young-Il; Goh, Junghwan; Hwang, Chanwook; Lee, Jongseok; Yu, Intae; Dudenas, Vytautas; Juodagalvis, Andrius; Vaitkus, Juozas; Ahmed, Ijaz; Ibrahim, Zainol Abidin; Komaragiri, Jyothsna Rani; Md Ali, Mohd Adli Bin; Mohamad Idris, Faridah; Wan Abdullah, Wan Ahmad Tajuddin; Yusli, Mohd Nizam; Zolkapli, Zukhaimira; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-De La Cruz, Ivan; Hernandez-Almada, Alberto; Lopez-Fernandez, Ricardo; Magaña Villalba, Ricardo; Mejia Guisao, Jhovanny; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Oropeza Barrera, Cristina; Vazquez Valencia, Fabiola; Carpinteyro, Severiano; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Uribe Estrada, Cecilia; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Shah, Mehar Ali; Shoaib, Muhammad; Waqas, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Bunkowski, Karol; Byszuk, Adrian; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nemallapudi, Mythra Varun; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Vischia, Pietro; Afanasiev, Serguei; Bunin, Pavel; Gavrilenko, Mikhail; Golutvin, Igor; Gorbunov, Ilya; Kamenev, Alexey; Karjavin, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Voytishin, Nikolay; Zarubin, Anatoli; Chtchipounov, Leonid; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Murzin, Victor; Oreshkin, Vadim; Sulimov, Valentin; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Toms, Maria; Vlasov, Evgueni; Zhokin, Alexander; Bylinkin, Alexander; Chadeeva, Marina; Chistov, Ruslan; Rusinov, Vladimir; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Rusakov, Sergey V; Terkulov, Adel; Baskakov, Alexey; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Klyukhin, Vyacheslav; Kodolova, Olga; Lokhtin, Igor; Miagkov, Igor; Obraztsov, Stepan; Petrushanko, Sergey; Savrin, Viktor; Snigirev, Alexander; Blinov, Vladimir; Skovpen, Yuri; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Elumakhov, Dmitry; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Cirkovic, Predrag; Devetak, Damir; Dordevic, Milos; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Barrio Luna, Mar; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Navarro De Martino, Eduardo; Pérez-Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Senghi Soares, Mara; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Cuevas, Javier; Fernandez Menendez, Javier; Gonzalez Caballero, Isidro; González Fernández, Juan Rodrigo; Palencia Cortezon, Enrique; Sanchez Cruz, Sergio; Suárez Andrés, Ignacio; Vizan Garcia, Jesus Manuel; Cabrillo, Iban Jose; Calderon, Alicia; Castiñeiras De Saa, Juan Ramon; Curras, Esteban; Fernandez, Marcos; Garcia-Ferrero, Juan; Gomez, Gervasio; Lopez Virto, Amparo; Marco, Jesus; Martinez Rivero, Celso; Matorras, Francisco; Piedra Gomez, Jonatan; Rodrigo, Teresa; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Trevisani, Nicolò; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Bachtis, Michail; Baillon, Paul; Ball, Austin; Barney, David; Bloch, Philippe; Bocci, Andrea; Bonato, Alessio; Botta, Cristina; Camporesi, Tiziano; Castello, Roberto; Cepeda, Maria; Cerminara, Gianluca; D'Alfonso, Mariarosaria; D'Enterria, David; Dabrowski, Anne; Daponte, Vincenzo; David Tinoco Mendes, Andre; De Gruttola, Michele; De Roeck, Albert; Di Marco, Emanuele; Dobson, Marc; Dorney, Brian; Du Pree, Tristan; Duggan, Daniel; Dünser, Marc; Dupont, Niels; Elliott-Peisert, Anna; Fartoukh, Stephane; Franzoni, Giovanni; Fulcher, Jonathan; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Girone, Maria; Glege, Frank; Gulhan, Doga; Gundacker, Stefan; Guthoff, Moritz; Hammer, Josef; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kieseler, Jan; Kirschenmann, Henning; Knünz, Valentin; Kornmayer, Andreas; Kortelainen, Matti J; Kousouris, Konstantinos; Krammer, Manfred; Lange, Clemens; Lecoq, Paul; Lourenco, Carlos; Lucchini, Marco Toliman; Malgeri, Luca; Mannelli, Marcello; Martelli, Arabella; Meijers, Frans; Merlin, Jeremie Alexandre; Mersi, Stefano; Meschi, Emilio; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Neugebauer, Hannes; Orfanelli, Styliani; Orsini, Luciano; Pape, Luc; Perez, Emmanuelle; Peruzzi, Marco; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Pierini, Maurizio; Racz, Attila; Reis, Thomas; Rolandi, Gigi; Rovere, Marco; Ruan, Manqi; Sakulin, Hannes; Sauvan, Jean-Baptiste; Schäfer, Christoph; Schwick, Christoph; Seidel, Markus; Sharma, Archana; Silva, Pedro; Sphicas, Paraskevas; Steggemann, Jan; Stoye, Markus; Takahashi, Yuta; Tosi, Mia; Treille, Daniel; Triossi, Andrea; Tsirou, Andromachi; Veckalns, Viesturs; Veres, Gabor Istvan; Wardle, Nicholas; Zagoździńska, Agnieszka; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; 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Doan, Thi Hien; Jain, Shilpi; Khurana, Raman; Konyushikhin, Maxim; Kuo, Chia-Ming; Lin, Willis; Lu, Yun-Ju; Pozdnyakov, Andrey; Yu, Shin-Shan; Kumar, Arun; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Dietz, Charles; Fiori, Francesco; Hou, George Wei-Shu; Hsiung, Yee; Liu, Yueh-Feng; Lu, Rong-Shyang; Miñano Moya, Mercedes; Paganis, Efstathios; Psallidas, Andreas; Tsai, Jui-fa; Tzeng, Yeng-Ming; Asavapibhop, Burin; Singh, Gurpreet; Srimanobhas, Norraphat; Suwonjandee, Narumon; Cerci, Salim; Damarseckin, Serdal; Demiroglu, Zuhal Seyma; Dozen, Candan; Dumanoglu, Isa; Girgis, Semiray; Gokbulut, Gul; Guler, Yalcin; Gurpinar, Emine; Hos, Ilknur; Kangal, Evrim Ersin; Kara, Ozgun; Kayis Topaksu, Aysel; Kiminsu, Ugur; Oglakci, Mehmet; Onengut, Gulsen; Ozdemir, Kadri; Sunar Cerci, Deniz; Tali, Bayram; Turkcapar, Semra; Zorbakir, Ibrahim Soner; Zorbilmez, Caglar; Bilin, Bugra; Bilmis, Selcuk; Isildak, Bora; Karapinar, Guler; Yalvac, Metin; Zeyrek, Mehmet; 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Benelli, Gabriele; Berry, Edmund; Cutts, David; Garabedian, Alex; Hakala, John; Heintz, Ulrich; Hogan, Julie Managan; Jesus, Orduna; Laird, Edward; Landsberg, Greg; Mao, Zaixing; Narain, Meenakshi; Piperov, Stefan; Sagir, Sinan; Spencer, Eric; Syarif, Rizki; Breedon, Richard; Breto, Guillermo; Burns, Dustin; Calderon De La Barca Sanchez, Manuel; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Erbacher, Robin; Flores, Chad; Funk, Garrett; Gardner, Michael; Ko, Winston; Lander, Richard; Mclean, Christine; Mulhearn, Michael; Pellett, Dave; Pilot, Justin; Shalhout, Shalhout; Smith, John; Squires, Michael; Stolp, Dustin; Tripathi, Mani; Wilbur, Scott; Yohay, Rachel; Cousins, Robert; Everaerts, Pieter; Florent, Alice; Hauser, Jay; Ignatenko, Mikhail; Saltzberg, David; Takasugi, Eric; Valuev, Vyacheslav; Weber, Matthias; Burt, Kira; Clare, Robert; Ellison, John Anthony; Gary, J William; Hanson, Gail; Heilman, Jesse; Jandir, Pawandeep; Kennedy, Elizabeth; Lacroix, Florent; Long, Owen Rosser; Olmedo Negrete, Manuel; Paneva, Mirena Ivova; Shrinivas, Amithabh; Si, Weinan; Wei, Hua; Wimpenny, Stephen; Yates, Brent; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; Derdzinski, Mark; Gerosa, Raffaele; Holzner, André; Klein, Daniel; Krutelyov, Vyacheslav; Letts, James; Macneill, Ian; Olivito, Dominick; Padhi, Sanjay; Pieri, Marco; Sani, Matteo; Sharma, Vivek; Simon, Sean; Tadel, Matevz; Vartak, Adish; Wasserbaech, Steven; Welke, Charles; Wood, John; Würthwein, Frank; Yagil, Avraham; Zevi Della Porta, Giovanni; Bhandari, Rohan; Bradmiller-Feld, John; Campagnari, Claudio; Dishaw, Adam; Dutta, Valentina; Flowers, Kristen; Franco Sevilla, Manuel; Geffert, Paul; George, Christopher; Golf, Frank; Gouskos, Loukas; Gran, Jason; Heller, Ryan; Incandela, Joe; Mccoll, Nickolas; Mullin, Sam Daniel; Ovcharova, Ana; Richman, Jeffrey; Stuart, David; Suarez, Indara; Yoo, Jaehyeok; Anderson, Dustin; Apresyan, Artur; Bendavid, Joshua; Bornheim, Adolf; Bunn, Julian; 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Loveless, Richard; Ojalvo, Isabel; Perry, Thomas; Polese, Giovanni; Ruggles, Tyler; Savin, Alexander; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Woods, Nathaniel

    2017-01-01

    Measurements of two- and multi-particle angular correlations in pp collisions at $\\sqrt{s} = $ 5, 7, and 13 TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0 pb$^{-1}$ (5 TeV), 6.2 pb$^{-1}$ (7 TeV), and 0.7 pb$^{-1}$ (13 TeV), were collected using the CMS detector at the LHC. The second-order ($v_2$) and third-order ($v_3$) azimuthal anisotropy harmonics of unidentified charged particles, as well as $v_2$ of $\\mathrm{ K_S }^0$ and $\\Lambda/\\overline{\\Lambda}$ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the $v_2$ values of charged hadrons (mostly pions), $\\mathrm{ K_S }^0$, and $\\Lambda/\\overline{\\Lambda}$, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below $p_{\\mathrm{T}} \\approx 2$ GeV/$c$. For 13 TeV data, the $v_2$ signals are also extracted from fou...

  17. Evidence for collectivity in pp collisions at the LHC

    CERN Document Server

    Khachatryan, Vardan; Tumasyan, Armen; Adam, Wolfgang; Aşılar, Ece; Bergauer, Thomas; Brandstetter, Johannes; Brondolin, Erica; Dragicevic, Marko; Erö, Janos; Flechl, Martin; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hartl, Christian; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; König, Axel; Krätschmer, Ilse; Liko, Dietrich; Matsushita, Takashi; Mikulec, Ivan; Rabady, Dinyar; Rad, Navid; Rahbaran, Babak; Rohringer, Herbert; Schieck, Jochen; Strauss, Josef; Treberer-Treberspurg, Wolfgang; Waltenberger, Wolfgang; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Alderweireldt, Sara; De Wolf, Eddi A; Janssen, Xavier; Lauwers, Jasper; Van De Klundert, Merijn; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Abu Zeid, Shimaa; Blekman, Freya; D'Hondt, Jorgen; Daci, Nadir; De Bruyn, Isabelle; Deroover, Kevin; Heracleous, Natalie; Lowette, Steven; Moortgat, Seth; Moreels, Lieselotte; Olbrechts, Annik; Python, Quentin; Tavernier, Stefaan; Van Doninck, Walter; Van Mulders, Petra; Van Parijs, Isis; Brun, Hugues; Caillol, Cécile; Clerbaux, Barbara; De Lentdecker, Gilles; Delannoy, Hugo; Fasanella, Giuseppe; Favart, Laurent; Goldouzian, Reza; Grebenyuk, Anastasia; Karapostoli, Georgia; Lenzi, Thomas; Léonard, Alexandre; Luetic, Jelena; Maerschalk, Thierry; Marinov, Andrey; Randle-conde, Aidan; Seva, Tomislav; Vander Velde, Catherine; Vanlaer, Pascal; Yonamine, Ryo; Zenoni, Florian; Zhang, Fengwangdong; Cimmino, Anna; Cornelis, Tom; Dobur, Didar; Fagot, Alexis; Garcia, Guillaume; Gul, Muhammad; Poyraz, Deniz; Salva Diblen, Sinem; Schöfbeck, Robert; Sharma, Archana; Tytgat, Michael; Van Driessche, Ward; Yazgan, Efe; Zaganidis, Nicolas; Bakhshiansohi, Hamed; Beluffi, Camille; Bondu, Olivier; Brochet, Sébastien; Bruno, Giacomo; Caudron, Adrien; De Visscher, Simon; Delaere, Christophe; Delcourt, Martin; Francois, Brieuc; Giammanco, Andrea; Jafari, Abideh; Jez, Pavel; Komm, Matthias; Lemaitre, Vincent; Magitteri, Alessio; Mertens, Alexandre; Musich, Marco; Nuttens, Claude; Piotrzkowski, Krzysztof; Quertenmont, Loic; Selvaggi, Michele; Vidal Marono, Miguel; Wertz, Sébastien; Beliy, Nikita; Aldá Júnior, Walter Luiz; Alves, Fábio Lúcio; Alves, Gilvan; Brito, Lucas; Hensel, Carsten; Moraes, Arthur; Pol, Maria Elena; Rebello Teles, Patricia; Belchior Batista Das Chagas, Ewerton; Carvalho, Wagner; Chinellato, Jose; Custódio, Analu; Da Costa, Eliza Melo; Da Silveira, Gustavo Gil; De Jesus Damiao, Dilson; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Huertas Guativa, Lina Milena; Malbouisson, Helena; Matos Figueiredo, Diego; Mora Herrera, Clemencia; Mundim, Luiz; Nogima, Helio; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Sznajder, Andre; Tonelli Manganote, Edmilson José; Vilela Pereira, Antonio; Ahuja, Sudha; Bernardes, Cesar Augusto; Dogra, Sunil; Tomei, Thiago; De Moraes Gregores, Eduardo; Mercadante, Pedro G; Moon, Chang-Seong; Novaes, Sergio F; Padula, Sandra; Romero Abad, David; Ruiz Vargas, José Cupertino; Aleksandrov, Aleksandar; Hadjiiska, Roumyana; Iaydjiev, Plamen; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Vutova, Mariana; Dimitrov, Anton; Glushkov, Ivan; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Fang, Wenxing; Ahmad, Muhammad; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Chen, Mingshui; Chen, Ye; Cheng, Tongguang; Jiang, Chun-Hua; Leggat, Duncan; Liu, Zhenan; Romeo, Francesco; Shaheen, Sarmad Masood; Spiezia, Aniello; Tao, Junquan; Wang, Chunjie; Wang, Zheng; Zhang, Huaqiao; Zhao, Jingzhou; Ban, Yong; Chen, Geng; Li, Qiang; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Wang, Dayong; Xu, Zijun; Avila, Carlos; Cabrera, Andrés; Chaparro Sierra, Luisa Fernanda; Florez, Carlos; Gomez, Juan Pablo; González Hernández, Carlos Felipe; Ruiz Alvarez, José David; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Puljak, Ivica; Ribeiro Cipriano, Pedro M; Sculac, Toni; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Ferencek, Dinko; Kadija, Kreso; Micanovic, Sasa; Sudic, Lucija; Susa, Tatjana; Attikis, Alexandros; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Rykaczewski, Hans; Finger, Miroslav; Finger Jr, Michael; Carrera Jarrin, Edgar; Abdelalim, Ahmed Ali; El-khateeb, Esraa; Salama, Elsayed; Calpas, Betty; Kadastik, Mario; Murumaa, Marion; Perrini, Lucia; Raidal, Martti; Tiko, Andres; Veelken, Christian; Eerola, Paula; Pekkanen, Juska; Voutilainen, Mikko; Härkönen, Jaakko; Karimäki, Veikko; Kinnunen, Ritva; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Tuominiemi, Jorma; Tuovinen, Esa; Wendland, Lauri; Talvitie, Joonas; Tuuva, Tuure; Besancon, Marc; Couderc, Fabrice; Dejardin, Marc; Denegri, Daniel; Fabbro, Bernard; Faure, Jean-Louis; Favaro, Carlotta; Ferri, Federico; Ganjour, Serguei; Ghosh, Saranya; Givernaud, Alain; Gras, Philippe; Hamel de Monchenault, Gautier; Jarry, Patrick; Kucher, Inna; Locci, Elizabeth; Machet, Martina; Malcles, Julie; Rander, John; Rosowsky, André; Titov, Maksym; Zghiche, Amina; Abdulsalam, Abdulla; Antropov, Iurii; Baffioni, Stephanie; Beaudette, Florian; Busson, Philippe; Cadamuro, Luca; Chapon, Emilien; Charlot, Claude; Davignon, Olivier; Granier de Cassagnac, Raphael; Jo, Mihee; Lisniak, Stanislav; Miné, Philippe; Nguyen, Matthew; Ochando, Christophe; Ortona, Giacomo; Paganini, Pascal; Pigard, Philipp; Regnard, Simon; Salerno, Roberto; Sirois, Yves; Strebler, Thomas; Yilmaz, Yetkin; Zabi, Alexandre; Agram, Jean-Laurent; Andrea, Jeremy; Aubin, Alexandre; Bloch, Daniel; Brom, Jean-Marie; Buttignol, Michael; Chabert, Eric Christian; Chanon, Nicolas; Collard, Caroline; Conte, Eric; Coubez, Xavier; Fontaine, Jean-Charles; Gelé, Denis; Goerlach, Ulrich; Le Bihan, Anne-Catherine; Skovpen, Kirill; Van Hove, Pierre; Gadrat, Sébastien; Beauceron, Stephanie; Bernet, Colin; Boudoul, Gaelle; Bouvier, Elvire; Carrillo Montoya, Camilo Andres; Chierici, Roberto; Contardo, Didier; Courbon, Benoit; Depasse, Pierre; El Mamouni, Houmani; Fan, Jiawei; Fay, Jean; Gascon, Susan; Gouzevitch, Maxime; Grenier, Gérald; Ille, Bernard; Lagarde, Francois; Laktineh, Imad Baptiste; Lethuillier, Morgan; Mirabito, Laurent; Pequegnot, Anne-Laure; Perries, Stephane; Popov, Andrey; Sabes, David; Sordini, Viola; Vander Donckt, Muriel; Verdier, Patrice; Viret, Sébastien; Toriashvili, Tengizi; Tsamalaidze, Zviad; Autermann, Christian; Beranek, Sarah; Feld, Lutz; Heister, Arno; Kiesel, Maximilian Knut; Klein, Katja; Lipinski, Martin; Ostapchuk, Andrey; Preuten, Marius; Raupach, Frank; Schael, Stefan; Schomakers, Christian; Schulte, Jan-Frederik; Schulz, Johannes; Verlage, Tobias; Weber, Hendrik; Zhukov, Valery; Albert, Andreas; Brodski, Michael; Dietz-Laursonn, Erik; Duchardt, Deborah; Endres, Matthias; Erdmann, Martin; Erdweg, Sören; Esch, Thomas; Fischer, Robert; Güth, Andreas; Hamer, Matthias; Hebbeker, Thomas; Heidemann, Carsten; Hoepfner, Kerstin; Knutzen, Simon; Merschmeyer, Markus; Meyer, Arnd; Millet, Philipp; Mukherjee, Swagata; Olschewski, Mark; Padeken, Klaas; Pook, Tobias; Radziej, Markus; Reithler, Hans; Rieger, Marcel; Scheuch, Florian; Sonnenschein, Lars; Teyssier, Daniel; Thüer, Sebastian; Cherepanov, Vladimir; Flügge, Günter; Haj Ahmad, Wael; Hoehle, Felix; Kargoll, Bastian; Kress, Thomas; Künsken, Andreas; Lingemann, Joschka; Müller, Thomas; Nehrkorn, Alexander; Nowack, Andreas; Nugent, Ian Michael; Pistone, Claudia; Pooth, Oliver; Stahl, Achim; Aldaya Martin, Maria; Asawatangtrakuldee, Chayanit; Beernaert, Kelly; Behnke, Olaf; Behrens, Ulf; Bin Anuar, Afiq Aizuddin; Borras, Kerstin; Campbell, Alan; Connor, Patrick; Contreras-Campana, Christian; Costanza, Francesco; Diez Pardos, Carmen; Dolinska, Ganna; Eckerlin, Guenter; Eckstein, Doris; Eren, Engin; Gallo, Elisabetta; Garay Garcia, Jasone; Geiser, Achim; Gizhko, Andrii; Grados Luyando, Juan Manuel; Gunnellini, Paolo; Harb, Ali; Hauk, Johannes; Hempel, Maria; Jung, Hannes; Kalogeropoulos, Alexis; Karacheban, Olena; Kasemann, Matthias; Keaveney, James; Kleinwort, Claus; Korol, Ievgen; Krücker, Dirk; Lange, Wolfgang; Lelek, Aleksandra; Leonard, Jessica; Lipka, Katerina; Lobanov, Artur; Lohmann, Wolfgang; Mankel, Rainer; Melzer-Pellmann, Isabell-Alissandra; Meyer, Andreas Bernhard; Mittag, Gregor; Mnich, Joachim; Mussgiller, Andreas; Ntomari, Eleni; Pitzl, Daniel; Raspereza, Alexei; Roland, Benoit; Sahin, Mehmet Özgür; Saxena, Pooja; Schoerner-Sadenius, Thomas; Seitz, Claudia; Spannagel, Simon; Stefaniuk, Nazar; Van Onsem, Gerrit Patrick; Walsh, Roberval; Wissing, Christoph; Blobel, Volker; Centis Vignali, Matteo; Draeger, Arne-Rasmus; Dreyer, Torben; Garutti, Erika; Gonzalez, Daniel; Haller, Johannes; Hoffmann, Malte; Junkes, Alexandra; Klanner, Robert; Kogler, Roman; Kovalchuk, Nataliia; Lapsien, Tobias; Lenz, Teresa; Marchesini, Ivan; Marconi, Daniele; Meyer, Mareike; Niedziela, Marek; Nowatschin, Dominik; Pantaleo, Felice; Peiffer, Thomas; Perieanu, Adrian; Poehlsen, Jennifer; Sander, Christian; Scharf, Christian; Schleper, Peter; Schmidt, Alexander; Schumann, Svenja; Schwandt, Joern; Stadie, Hartmut; Steinbrück, Georg; Stober, Fred-Markus Helmut; Stöver, Marc; Tholen, Heiner; Troendle, Daniel; Usai, Emanuele; Vanelderen, Lukas; Vanhoefer, Annika; Vormwald, Benedikt; Barth, Christian; Baus, Colin; Berger, Joram; Butz, Erik; Chwalek, Thorsten; Colombo, Fabio; De Boer, Wim; Dierlamm, Alexander; Fink, Simon; Friese, Raphael; Giffels, Manuel; Gilbert, Andrew; Goldenzweig, Pablo; Haitz, Dominik; Hartmann, Frank; Heindl, Stefan Michael; Husemann, Ulrich; Katkov, Igor; Lobelle Pardo, Patricia; Maier, Benedikt; Mildner, Hannes; Mozer, Matthias Ulrich; Müller, Thomas; Plagge, Michael; Quast, Gunter; Rabbertz, Klaus; Röcker, Steffen; Roscher, Frank; Schröder, Matthias; Shvetsov, Ivan; Sieber, Georg; Simonis, Hans-Jürgen; Ulrich, Ralf; Wagner-Kuhr, Jeannine; Wayand, Stefan; Weber, Marc; Weiler, Thomas; Williamson, Shawn; Wöhrmann, Clemens; Wolf, Roger; Anagnostou, Georgios; Daskalakis, Georgios; Geralis, Theodoros; Giakoumopoulou, Viktoria Athina; Kyriakis, Aristotelis; Loukas, Demetrios; Topsis-Giotis, Iasonas; Kesisoglou, Stilianos; Panagiotou, Apostolos; Saoulidou, Niki; Tziaferi, Eirini; Evangelou, Ioannis; Flouris, Giannis; Foudas, Costas; Kokkas, Panagiotis; Loukas, Nikitas; Manthos, Nikolaos; Papadopoulos, Ioannis; Paradas, Evangelos; Filipovic, Nicolas; Bencze, Gyorgy; Hajdu, Csaba; Hidas, Pàl; Horvath, Dezso; Sikler, Ferenc; Veszpremi, Viktor; Vesztergombi, Gyorgy; Zsigmond, Anna Julia; Beni, Noemi; Czellar, Sandor; Karancsi, János; Makovec, Alajos; Molnar, Jozsef; Szillasi, Zoltan; Bartók, Márton; Raics, Peter; Trocsanyi, Zoltan Laszlo; Ujvari, Balazs; Bahinipati, Seema; Choudhury, Somnath; Mal, Prolay; Mandal, Koushik; Nayak, Aruna; Sahoo, Deepak Kumar; Sahoo, Niladribihari; Swain, Sanjay Kumar; Bansal, Sunil; Beri, Suman Bala; Bhatnagar, Vipin; Chawla, Ridhi; Bhawandeep, Bhawandeep; Kalsi, Amandeep Kaur; Kaur, Anterpreet; Kaur, Manjit; Kumar, Ramandeep; Mehta, Ankita; Mittal, Monika; Singh, Jasbir; Walia, Genius; Kumar, Ashok; Bhardwaj, Ashutosh; Choudhary, Brajesh C; Garg, Rocky Bala; Keshri, Sumit; Malhotra, Shivali; Naimuddin, Md; Nishu, Nishu; Ranjan, Kirti; Sharma, Ramkrishna; Sharma, Varun; Bhattacharya, Rajarshi; Bhattacharya, Satyaki; Chatterjee, Kalyanmoy; Dey, Sourav; Dutt, Suneel; Dutta, Suchandra; Ghosh, Shamik; Majumdar, Nayana; Modak, Atanu; Mondal, Kuntal; Mukhopadhyay, Supratik; Nandan, Saswati; Purohit, Arnab; Roy, Ashim; Roy, Debarati; Roy Chowdhury, Suvankar; Sarkar, Subir; Sharan, Manoj; Thakur, Shalini; Behera, Prafulla Kumar; Chudasama, Ruchi; Dutta, Dipanwita; Jha, Vishwajeet; Kumar, Vineet; Mohanty, Ajit Kumar; Netrakanti, Pawan Kumar; Pant, Lalit Mohan; Shukla, Prashant; Topkar, Anita; Aziz, Tariq; Dugad, Shashikant; Kole, Gouranga; Mahakud, Bibhuprasad; Mitra, Soureek; Mohanty, Gagan Bihari; Parida, Bibhuti; Sur, Nairit; Sutar, Bajrang; Banerjee, Sudeshna; Bhowmik, Sandeep; Dewanjee, Ram Krishna; Ganguly, Sanmay; Guchait, Monoranjan; Jain, Sandhya; Kumar, Sanjeev; Maity, Manas; Majumder, Gobinda; Mazumdar, Kajari; Sarkar, Tanmay; Wickramage, Nadeesha; Chauhan, Shubhanshu; Dube, Sourabh; Hegde, Vinay; Kapoor, Anshul; Kothekar, Kunal; Rane, Aditee; Sharma, Seema; Behnamian, Hadi; Chenarani, Shirin; Eskandari Tadavani, Esmaeel; Etesami, Seyed Mohsen; Fahim, Ali; Khakzad, Mohsen; Mohammadi Najafabadi, Mojtaba; Naseri, Mohsen; Paktinat Mehdiabadi, Saeid; Rezaei Hosseinabadi, Ferdos; Safarzadeh, Batool; Zeinali, Maryam; Felcini, Marta; Grunewald, Martin; Abbrescia, Marcello; Calabria, Cesare; Caputo, Claudio; Colaleo, Anna; Creanza, Donato; Cristella, Leonardo; De Filippis, Nicola; De Palma, Mauro; Fiore, Luigi; Iaselli, Giuseppe; Maggi, Giorgio; Maggi, Marcello; Miniello, Giorgia; My, Salvatore; Nuzzo, Salvatore; Pompili, Alexis; Pugliese, Gabriella; Radogna, Raffaella; Ranieri, Antonio; Selvaggi, Giovanna; Silvestris, Lucia; Venditti, Rosamaria; Verwilligen, Piet; Abbiendi, Giovanni; Battilana, Carlo; Bonacorsi, Daniele; Braibant-Giacomelli, Sylvie; Brigliadori, Luca; Campanini, Renato; Capiluppi, Paolo; Castro, Andrea; Cavallo, Francesca Romana; Chhibra, Simranjit Singh; Codispoti, Giuseppe; Cuffiani, Marco; Dallavalle, Gaetano-Marco; Fabbri, Fabrizio; Fanfani, Alessandra; Fasanella, Daniele; Giacomelli, Paolo; Grandi, Claudio; Guiducci, Luigi; Marcellini, Stefano; Masetti, Gianni; Montanari, Alessandro; Navarria, Francesco; Perrotta, Andrea; Rossi, Antonio; Rovelli, Tiziano; Siroli, Gian Piero; Tosi, Nicolò; Albergo, Sebastiano; Chiorboli, Massimiliano; Costa, Salvatore; Di Mattia, Alessandro; Giordano, Ferdinando; Potenza, Renato; Tricomi, Alessia; Tuve, Cristina; Barbagli, Giuseppe; Ciulli, Vitaliano; Civinini, Carlo; D'Alessandro, Raffaello; Focardi, Ettore; Gori, Valentina; Lenzi, Piergiulio; Meschini, Marco; Paoletti, Simone; Sguazzoni, Giacomo; Viliani, Lorenzo; Benussi, Luigi; Bianco, Stefano; Fabbri, Franco; Piccolo, Davide; Primavera, Federica; Calvelli, Valerio; Ferro, Fabrizio; Lo Vetere, Maurizio; Monge, Maria Roberta; Robutti, Enrico; Tosi, Silvano; Brianza, Luca; Dinardo, Mauro Emanuele; Fiorendi, Sara; Gennai, Simone; Ghezzi, Alessio; Govoni, Pietro; Malberti, Martina; Malvezzi, Sandra; Manzoni, Riccardo Andrea; Marzocchi, Badder; Menasce, Dario; Moroni, Luigi; Paganoni, Marco; Pedrini, Daniele; Pigazzini, Simone; Ragazzi, Stefano; Tabarelli de Fatis, Tommaso; Buontempo, Salvatore; Cavallo, Nicola; De Nardo, Guglielmo; Di Guida, Salvatore; Esposito, Marco; Fabozzi, Francesco; Iorio, Alberto Orso Maria; Lanza, Giuseppe; Lista, Luca; Meola, Sabino; Paolucci, Pierluigi; Sciacca, Crisostomo; Thyssen, Filip; Azzi, Patrizia; Bacchetta, Nicola; Benato, Lisa; Bisello, Dario; Boletti, Alessio; Carlin, Roberto; Carvalho Antunes De Oliveira, Alexandra; Checchia, Paolo; Dall'Osso, Martino; De Castro Manzano, Pablo; Dorigo, Tommaso; Dosselli, Umberto; Gasparini, Fabrizio; Gasparini, Ugo; Gozzelino, Andrea; Lacaprara, Stefano; Margoni, Martino; Meneguzzo, Anna Teresa; Pazzini, Jacopo; Pozzobon, Nicola; Ronchese, Paolo; Simonetto, Franco; Torassa, Ezio; Zanetti, Marco; Zotto, Pierluigi; Zucchetta, Alberto; Zumerle, Gianni; Braghieri, Alessandro; Magnani, Alice; Montagna, Paolo; Ratti, Sergio P; Re, Valerio; Riccardi, Cristina; Salvini, Paola; Vai, Ilaria; Vitulo, Paolo; Alunni Solestizi, Luisa; Bilei, Gian Mario; Ciangottini, Diego; Fanò, Livio; Lariccia, Paolo; Leonardi, Roberto; Mantovani, Giancarlo; Menichelli, Mauro; Saha, Anirban; Santocchia, Attilio; Androsov, Konstantin; Azzurri, Paolo; Bagliesi, Giuseppe; Bernardini, Jacopo; Boccali, Tommaso; Castaldi, Rino; Ciocci, Maria Agnese; Dell'Orso, Roberto; Donato, Silvio; Fedi, Giacomo; Giassi, Alessandro; Grippo, Maria Teresa; Ligabue, Franco; Lomtadze, Teimuraz; Martini, Luca; Messineo, Alberto; Palla, Fabrizio; Rizzi, Andrea; Savoy-Navarro, Aurore; Spagnolo, Paolo; Tenchini, Roberto; Tonelli, Guido; Venturi, Andrea; Verdini, Piero Giorgio; Barone, Luciano; Cavallari, Francesca; Cipriani, Marco; D'imperio, Giulia; Del Re, Daniele; Diemoz, Marcella; Gelli, Simone; Longo, Egidio; Margaroli, Fabrizio; Meridiani, Paolo; Organtini, Giovanni; Paramatti, Riccardo; Preiato, Federico; Rahatlou, Shahram; Rovelli, Chiara; Santanastasio, Francesco; Amapane, Nicola; Arcidiacono, Roberta; Argiro, Stefano; Arneodo, Michele; Bartosik, Nazar; Bellan, Riccardo; Biino, Cristina; Cartiglia, Nicolo; Cenna, Francesca; Costa, Marco; Covarelli, Roberto; Degano, Alessandro; Demaria, Natale; Finco, Linda; Kiani, Bilal; Mariotti, Chiara; Maselli, Silvia; Migliore, Ernesto; Monaco, Vincenzo; Monteil, Ennio; Obertino, Maria Margherita; Pacher, Luca; Pastrone, Nadia; Pelliccioni, Mario; Pinna Angioni, Gian Luca; Ravera, Fabio; Romero, Alessandra; Ruspa, Marta; Sacchi, Roberto; Shchelina, Ksenia; Sola, Valentina; Solano, Ada; Staiano, Amedeo; Traczyk, Piotr; Belforte, Stefano; Casarsa, Massimo; Cossutti, Fabio; Della Ricca, Giuseppe; La Licata, Chiara; Schizzi, Andrea; Zanetti, Anna; Kim, Dong Hee; Kim, Gui Nyun; Kim, Min Suk; Lee, Sangeun; Lee, Seh Wook; Oh, Young Do; Sekmen, Sezen; Son, Dong-Chul; Yang, Yu Chul; Lee, Ari; Kim, Hyunchul; Brochero Cifuentes, Javier Andres; Kim, Tae Jeong; Cho, Sungwoong; Choi, Suyong; Go, Yeonju; Gyun, Dooyeon; Ha, Seungkyu; Hong, Byung-Sik; Jo, Youngkwon; Kim, Yongsun; Lee, Byounghoon; Lee, Kisoo; Lee, Kyong Sei; Lee, Songkyo; Lim, Jaehoon; Park, Sung Keun; Roh, Youn; Almond, John; Kim, Junho; Lee, Haneol; Oh, Sung Bin; Radburn-Smith, Benjamin Charles; Seo, Seon-hee; Yang, Unki; Yoo, Hwi Dong; Yu, Geum Bong; Choi, Minkyoo; Kim, Hyunyong; Kim, Ji Hyun; Lee, Jason Sang Hun; Park, Inkyu; Ryu, Geonmo; Ryu, Min Sang; Choi, Young-Il; Goh, Junghwan; Hwang, Chanwook; Lee, Jongseok; Yu, Intae; Dudenas, Vytautas; Juodagalvis, Andrius; Vaitkus, Juozas; Ahmed, Ijaz; Ibrahim, Zainol Abidin; Komaragiri, Jyothsna Rani; Md Ali, Mohd Adli Bin; Mohamad Idris, Faridah; Wan Abdullah, Wan Ahmad Tajuddin; Yusli, Mohd Nizam; Zolkapli, Zukhaimira; Castilla-Valdez, Heriberto; De La Cruz-Burelo, Eduard; Heredia-De La Cruz, Ivan; Hernandez-Almada, Alberto; Lopez-Fernandez, Ricardo; Magaña Villalba, Ricardo; Mejia Guisao, Jhovanny; Sánchez Hernández, Alberto; Carrillo Moreno, Salvador; Oropeza Barrera, Cristina; Vazquez Valencia, Fabiola; Carpinteyro, Severiano; Pedraza, Isabel; Salazar Ibarguen, Humberto Antonio; Uribe Estrada, Cecilia; Morelos Pineda, Antonio; Krofcheck, David; Butler, Philip H; Ahmad, Ashfaq; Ahmad, Muhammad; Hassan, Qamar; Hoorani, Hafeez R; Khan, Wajid Ali; Shah, Mehar Ali; Shoaib, Muhammad; Waqas, Muhammad; Bialkowska, Helena; Bluj, Michal; Boimska, Bożena; Frueboes, Tomasz; Górski, Maciej; Kazana, Malgorzata; Nawrocki, Krzysztof; Romanowska-Rybinska, Katarzyna; Szleper, Michal; Zalewski, Piotr; Bunkowski, Karol; Byszuk, Adrian; Doroba, Krzysztof; Kalinowski, Artur; Konecki, Marcin; Krolikowski, Jan; Misiura, Maciej; Olszewski, Michal; Walczak, Marek; Bargassa, Pedrame; Beirão Da Cruz E Silva, Cristóvão; Di Francesco, Agostino; Faccioli, Pietro; Ferreira Parracho, Pedro Guilherme; Gallinaro, Michele; Hollar, Jonathan; Leonardo, Nuno; Lloret Iglesias, Lara; Nemallapudi, Mythra Varun; Rodrigues Antunes, Joao; Seixas, Joao; Toldaiev, Oleksii; Vadruccio, Daniele; Varela, Joao; Vischia, Pietro; Afanasiev, Serguei; Bunin, Pavel; Gavrilenko, Mikhail; Golutvin, Igor; Gorbunov, Ilya; Kamenev, Alexey; Karjavin, Vladimir; Lanev, Alexander; Malakhov, Alexander; Matveev, Viktor; Moisenz, Petr; Palichik, Vladimir; Perelygin, Victor; Shmatov, Sergey; Shulha, Siarhei; Skatchkov, Nikolai; Smirnov, Vitaly; Voytishin, Nikolay; Zarubin, Anatoli; Chtchipounov, Leonid; Golovtsov, Victor; Ivanov, Yury; Kim, Victor; Kuznetsova, Ekaterina; Murzin, Victor; Oreshkin, Vadim; Sulimov, Valentin; Vorobyev, Alexey; Andreev, Yuri; Dermenev, Alexander; Gninenko, Sergei; Golubev, Nikolai; Karneyeu, Anton; Kirsanov, Mikhail; Krasnikov, Nikolai; Pashenkov, Anatoli; Tlisov, Danila; Toropin, Alexander; Epshteyn, Vladimir; Gavrilov, Vladimir; Lychkovskaya, Natalia; Popov, Vladimir; Pozdnyakov, Ivan; Safronov, Grigory; Spiridonov, Alexander; Toms, Maria; Vlasov, Evgueni; Zhokin, Alexander; Bylinkin, Alexander; Chadeeva, Marina; Chistov, Ruslan; Rusinov, Vladimir; Andreev, Vladimir; Azarkin, Maksim; Dremin, Igor; Kirakosyan, Martin; Leonidov, Andrey; Rusakov, Sergey V; Terkulov, Adel; Baskakov, Alexey; Belyaev, Andrey; Boos, Edouard; Dubinin, Mikhail; Dudko, Lev; Ershov, Alexander; Gribushin, Andrey; Klyukhin, Vyacheslav; Kodolova, Olga; Lokhtin, Igor; Miagkov, Igor; Obraztsov, Stepan; Petrushanko, Sergey; Savrin, Viktor; Snigirev, Alexander; Blinov, Vladimir; Skovpen, Yuri; Azhgirey, Igor; Bayshev, Igor; Bitioukov, Sergei; Elumakhov, Dmitry; Kachanov, Vassili; Kalinin, Alexey; Konstantinov, Dmitri; Krychkine, Victor; Petrov, Vladimir; Ryutin, Roman; Sobol, Andrei; Troshin, Sergey; Tyurin, Nikolay; Uzunian, Andrey; Volkov, Alexey; Adzic, Petar; Cirkovic, Predrag; Devetak, Damir; Dordevic, Milos; Milosevic, Jovan; Rekovic, Vladimir; Alcaraz Maestre, Juan; Barrio Luna, Mar; Calvo, Enrique; Cerrada, Marcos; Chamizo Llatas, Maria; Colino, Nicanor; De La Cruz, Begona; Delgado Peris, Antonio; Escalante Del Valle, Alberto; Fernandez Bedoya, Cristina; Fernández Ramos, Juan Pablo; Flix, Jose; Fouz, Maria Cruz; Garcia-Abia, Pablo; Gonzalez Lopez, Oscar; Goy Lopez, Silvia; Hernandez, Jose M; Josa, Maria Isabel; Navarro De Martino, Eduardo; Pérez-Calero Yzquierdo, Antonio María; Puerta Pelayo, Jesus; Quintario Olmeda, Adrián; Redondo, Ignacio; Romero, Luciano; Soares, Mara Senghi; de Trocóniz, Jorge F; Missiroli, Marino; Moran, Dermot; Cuevas, Javier; Fernandez Menendez, Javier; Gonzalez Caballero, Isidro; González Fernández, Juan Rodrigo; Palencia Cortezon, Enrique; Sanchez Cruz, Sergio; Suárez Andrés, Ignacio; Vizan Garcia, Jesus Manuel; Cabrillo, Iban Jose; Calderon, Alicia; Castiñeiras De Saa, Juan Ramon; Curras, Esteban; Fernandez, Marcos; Garcia-Ferrero, Juan; Gomez, Gervasio; Lopez Virto, Amparo; Marco, Jesus; Martinez Rivero, Celso; Matorras, Francisco; Piedra Gomez, Jonatan; Rodrigo, Teresa; Ruiz-Jimeno, Alberto; Scodellaro, Luca; Trevisani, Nicolò; Vila, Ivan; Vilar Cortabitarte, Rocio; Abbaneo, Duccio; Auffray, Etiennette; Auzinger, Georg; Bachtis, Michail; Baillon, Paul; Ball, Austin; Barney, David; Bloch, Philippe; Bocci, Andrea; Bonato, Alessio; Botta, Cristina; Camporesi, Tiziano; Castello, Roberto; Cepeda, Maria; Cerminara, Gianluca; D'Alfonso, Mariarosaria; D'Enterria, David; Dabrowski, Anne; Daponte, Vincenzo; David Tinoco Mendes, Andre; De Gruttola, Michele; De Roeck, Albert; Di Marco, Emanuele; Dobson, Marc; Dorney, Brian; Du Pree, Tristan; Duggan, Daniel; Dünser, Marc; Dupont, Niels; Elliott-Peisert, Anna; Fartoukh, Stephane; Franzoni, Giovanni; Fulcher, Jonathan; Funk, Wolfgang; Gigi, Dominique; Gill, Karl; Girone, Maria; Glege, Frank; Gulhan, Doga; Gundacker, Stefan; Guthoff, Moritz; Hammer, Josef; Harris, Philip; Hegeman, Jeroen; Innocente, Vincenzo; Janot, Patrick; Kieseler, Jan; Kirschenmann, Henning; Knünz, Valentin; Kornmayer, Andreas; Kortelainen, Matti J; Kousouris, Konstantinos; Krammer, Manfred; Lange, Clemens; Lecoq, Paul; Lourenco, Carlos; Lucchini, Marco Toliman; Malgeri, Luca; Mannelli, Marcello; Martelli, Arabella; Meijers, Frans; Merlin, Jeremie Alexandre; Mersi, Stefano; Meschi, Emilio; Moortgat, Filip; Morovic, Srecko; Mulders, Martijn; Neugebauer, Hannes; Orfanelli, Styliani; Orsini, Luciano; Pape, Luc; Perez, Emmanuelle; Peruzzi, Marco; Petrilli, Achille; Petrucciani, Giovanni; Pfeiffer, Andreas; Pierini, Maurizio; Racz, Attila; Reis, Thomas; Rolandi, Gigi; Rovere, Marco; Ruan, Manqi; Sakulin, Hannes; Sauvan, Jean-Baptiste; Schäfer, Christoph; Schwick, Christoph; Seidel, Markus; Sharma, Archana; Silva, Pedro; Sphicas, Paraskevas; Steggemann, Jan; Stoye, Markus; Takahashi, Yuta; Tosi, Mia; Treille, Daniel; Triossi, Andrea; Tsirou, Andromachi; Veckalns, Viesturs; Veres, Gabor Istvan; Wardle, Nicholas; Zagoździńska, Agnieszka; Zeuner, Wolfram Dietrich; Bertl, Willi; Deiters, Konrad; Erdmann, Wolfram; Horisberger, Roland; Ingram, Quentin; Kaestli, Hans-Christian; Kotlinski, Danek; Langenegger, Urs; Rohe, Tilman; Bachmair, Felix; Bäni, Lukas; Bianchini, Lorenzo; Casal, Bruno; Dissertori, Günther; Dittmar, Michael; Donegà, Mauro; Grab, Christoph; Heidegger, Constantin; Hits, Dmitry; Hoss, Jan; Kasieczka, Gregor; Lecomte, Pierre; Lustermann, Werner; Mangano, Boris; Marionneau, Matthieu; Martinez Ruiz del Arbol, Pablo; Masciovecchio, Mario; Meinhard, Maren Tabea; Meister, Daniel; Micheli, Francesco; Musella, Pasquale; Nessi-Tedaldi, Francesca; Pandolfi, Francesco; Pata, Joosep; Pauss, Felicitas; Perrin, Gaël; Perrozzi, Luca; Quittnat, Milena; Rossini, Marco; Schönenberger, Myriam; Starodumov, Andrei; Tavolaro, Vittorio Raoul; Theofilatos, Konstantinos; Wallny, Rainer; Aarrestad, Thea Klaeboe; Amsler, Claude; Caminada, Lea; Canelli, Maria Florencia; De Cosa, Annapaola; Galloni, Camilla; Hinzmann, Andreas; Hreus, Tomas; Kilminster, Benjamin; Ngadiuba, Jennifer; Pinna, Deborah; Rauco, Giorgia; Robmann, Peter; Salerno, Daniel; Yang, Yong; Candelise, Vieri; Doan, Thi Hien; Jain, Shilpi; Khurana, Raman; Konyushikhin, Maxim; Kuo, Chia-Ming; Lin, Willis; Lu, Yun-Ju; Pozdnyakov, Andrey; Yu, Shin-Shan; Kumar, Arun; Chang, Paoti; Chang, You-Hao; Chang, Yu-Wei; Chao, Yuan; Chen, Kai-Feng; Chen, Po-Hsun; Dietz, Charles; Fiori, Francesco; Hou, George Wei-Shu; Hsiung, Yee; Liu, Yueh-Feng; Lu, Rong-Shyang; Miñano Moya, Mercedes; Paganis, Efstathios; Psallidas, Andreas; Tsai, Jui-fa; Tzeng, Yeng-Ming; Asavapibhop, Burin; Singh, Gurpreet; Srimanobhas, Norraphat; Suwonjandee, Narumon; Cerci, Salim; Damarseckin, Serdal; Demiroglu, Zuhal Seyma; Dozen, Candan; Dumanoglu, Isa; Girgis, Semiray; Gokbulut, Gul; Guler, Yalcin; Gurpinar, Emine; Hos, Ilknur; Kangal, Evrim Ersin; Kara, Ozgun; Kayis Topaksu, Aysel; Kiminsu, Ugur; Oglakci, Mehmet; Onengut, Gulsen; Ozdemir, Kadri; Sunar Cerci, Deniz; Tali, Bayram; Turkcapar, Semra; Zorbakir, Ibrahim Soner; Zorbilmez, Caglar; Bilin, Bugra; Bilmis, Selcuk; Isildak, Bora; Karapinar, Guler; Yalvac, Metin; Zeyrek, Mehmet; Gülmez, Erhan; Kaya, Mithat; Kaya, Ozlem; Yetkin, Elif Asli; Yetkin, Taylan; Cakir, Altan; Cankocak, Kerem; Sen, Sercan; Grynyov, Boris; Levchuk, Leonid; Sorokin, Pavel; Aggleton, Robin; Ball, Fionn; Beck, Lana; Brooke, James John; Burns, Douglas; Clement, Emyr; Cussans, David; Flacher, Henning; Goldstein, Joel; Grimes, Mark; Heath, Greg P; Heath, Helen F; Jacob, Jeson; Kreczko, Lukasz; Lucas, Chris; Newbold, Dave M; Paramesvaran, Sudarshan; Poll, Anthony; Sakuma, Tai; Seif El Nasr-storey, Sarah; Smith, Dominic; Smith, Vincent J; Barducci, Daniele; Belyaev, Alexander; Brew, Christopher; Brown, Robert M; Calligaris, Luigi; Cieri, Davide; Cockerill, David JA; Coughlan, John A; Harder, Kristian; Harper, Sam; Olaiya, Emmanuel; Petyt, David; Shepherd-Themistocleous, Claire; Thea, Alessandro; Tomalin, Ian R; Williams, Thomas; Baber, Mark; Bainbridge, Robert; Buchmuller, Oliver; Bundock, Aaron; Burton, Darren; Casasso, Stefano; Citron, Matthew; Colling, David; Corpe, Louie; Dauncey, Paul; Davies, Gavin; De Wit, Adinda; Della Negra, Michel; Di Maria, Riccardo; Dunne, Patrick; Elwood, Adam; Futyan, David; Haddad, Yacine; Hall, Geoffrey; Iles, Gregory; James, Thomas; Lane, Rebecca; Laner, Christian; Lucas, Robyn; Lyons, Louis; Magnan, Anne-Marie; Malik, Sarah; Mastrolorenzo, Luca; Nash, Jordan; Nikitenko, Alexander; Pela, Joao; Penning, Bjoern; Pesaresi, Mark; Raymond, David Mark; Richards, Alexander; Rose, Andrew; Seez, Christopher; Summers, Sioni; Tapper, Alexander; Uchida, Kirika; Vazquez Acosta, Monica; Virdee, Tejinder; Wright, Jack; Zenz, Seth Conrad; Cole, Joanne; Hobson, Peter R; Khan, Akram; Kyberd, Paul; Leslie, Dawn; Reid, Ivan; Symonds, Philip; Teodorescu, Liliana; Turner, Mark; Borzou, Ahmad; Call, Kenneth; Dittmann, Jay; Hatakeyama, Kenichi; Liu, Hongxuan; Pastika, Nathaniel; Charaf, Otman; Cooper, Seth; Henderson, Conor; Rumerio, Paolo; West, Christopher; Arcaro, Daniel; Avetisyan, Aram; Bose, Tulika; Gastler, Daniel; Rankin, Dylan; Richardson, Clint; Rohlf, James; Sulak, Lawrence; Zou, David; Benelli, Gabriele; Berry, Edmund; Cutts, David; Garabedian, Alex; Hakala, John; Heintz, Ulrich; Hogan, Julie Managan; Jesus, Orduna; Laird, Edward; Landsberg, Greg; Mao, Zaixing; Narain, Meenakshi; Piperov, Stefan; Sagir, Sinan; Spencer, Eric; Syarif, Rizki; Breedon, Richard; Breto, Guillermo; Burns, Dustin; Calderon De La Barca Sanchez, Manuel; Chauhan, Sushil; Chertok, Maxwell; Conway, John; Conway, Rylan; Cox, Peter Timothy; Erbacher, Robin; Flores, Chad; Funk, Garrett; Gardner, Michael; Ko, Winston; Lander, Richard; Mclean, Christine; Mulhearn, Michael; Pellett, Dave; Pilot, Justin; Shalhout, Shalhout; Smith, John; Squires, Michael; Stolp, Dustin; Tripathi, Mani; Wilbur, Scott; Yohay, Rachel; Cousins, Robert; Everaerts, Pieter; Florent, Alice; Hauser, Jay; Ignatenko, Mikhail; Saltzberg, David; Takasugi, Eric; Valuev, Vyacheslav; Weber, Matthias; Burt, Kira; Clare, Robert; Ellison, John Anthony; Gary, J William; Hanson, Gail; Heilman, Jesse; Jandir, Pawandeep; Kennedy, Elizabeth; Lacroix, Florent; Long, Owen Rosser; Olmedo Negrete, Manuel; Paneva, Mirena Ivova; Shrinivas, Amithabh; Si, Weinan; Wei, Hua; Wimpenny, Stephen; Yates, Brent; Branson, James G; Cerati, Giuseppe Benedetto; Cittolin, Sergio; Derdzinski, Mark; Gerosa, Raffaele; Holzner, André; Klein, Daniel; Krutelyov, Vyacheslav; Letts, James; Macneill, Ian; Olivito, Dominick; Padhi, Sanjay; Pieri, Marco; Sani, Matteo; Sharma, Vivek; Simon, Sean; Tadel, Matevz; Vartak, Adish; Wasserbaech, Steven; Welke, Charles; Wood, John; Würthwein, Frank; Yagil, Avraham; Zevi Della Porta, Giovanni; Bhandari, Rohan; Bradmiller-Feld, John; Campagnari, Claudio; Dishaw, Adam; Dutta, Valentina; Flowers, Kristen; Franco Sevilla, Manuel; Geffert, Paul; George, Christopher; Golf, Frank; Gouskos, Loukas; Gran, Jason; Heller, Ryan; Incandela, Joe; Mccoll, Nickolas; Mullin, Sam Daniel; Ovcharova, Ana; Richman, Jeffrey; Stuart, David; Suarez, Indara; Yoo, Jaehyeok; Anderson, Dustin; Apresyan, Artur; Bendavid, Joshua; Bornheim, Adolf; Bunn, Julian; Chen, Yi; Duarte, Javier; Lawhorn, Jay Mathew; Mott, Alexander; Newman, Harvey B; Pena, Cristian; Spiropulu, Maria; Vlimant, Jean-Roch; Xie, Si; Zhu, Ren-Yuan; Andrews, Michael Benjamin; Azzolini, Virginia; Ferguson, Thomas; Paulini, Manfred; Russ, James; Sun, Menglei; Vogel, Helmut; Vorobiev, Igor; Cumalat, John Perry; Ford, William T; Jensen, Frank; Johnson, Andrew; Krohn, Michael; Mulholland, Troy; Stenson, Kevin; Wagner, Stephen Robert; Alexander, James; Chaves, Jorge; Chu, Jennifer; Dittmer, Susan; Mcdermott, Kevin; Mirman, Nathan; Nicolas Kaufman, Gala; Patterson, Juliet Ritchie; Rinkevicius, Aurelijus; Ryd, Anders; Skinnari, Louise; Soffi, Livia; Tan, Shao Min; Tao, Zhengcheng; Thom, Julia; Tucker, Jordan; Wittich, Peter; Zientek, Margaret; Winn, Dave; Abdullin, Salavat; Albrow, Michael; Apollinari, Giorgio; Banerjee, Sunanda; Bauerdick, Lothar AT; Beretvas, Andrew; Berryhill, Jeffrey; Bhat, Pushpalatha C; Bolla, Gino; Burkett, Kevin; Butler, Joel Nathan; Cheung, Harry; Chlebana, Frank; Cihangir, Selcuk; Cremonesi, Matteo; Elvira, Victor Daniel; Fisk, Ian; Freeman, Jim; Gottschalk, Erik; Gray, Lindsey; Green, Dan; Grünendahl, Stefan; Gutsche, Oliver; Hare, Daryl; Harris, Robert M; Hasegawa, Satoshi; Hirschauer, James; Hu, Zhen; Jayatilaka, Bodhitha; Jindariani, Sergo; Johnson, Marvin; Joshi, Umesh; Klima, Boaz; Kreis, Benjamin; Lammel, Stephan; Linacre, Jacob; Lincoln, Don; Lipton, Ron; Liu, Tiehui; Lopes De Sá, Rafael; Lykken, Joseph; Maeshima, Kaori; Magini, Nicolo; Marraffino, John Michael; Maruyama, Sho; Mason, David; McBride, Patricia; Merkel, Petra; Mrenna, Stephen; Nahn, Steve; Newman-Holmes, Catherine; O'Dell, Vivian; Pedro, Kevin; Prokofyev, Oleg; Rakness, Gregory; Ristori, Luciano; Sexton-Kennedy, Elizabeth; Soha, Aron; Spalding, William J; Spiegel, Leonard; Stoynev, Stoyan; Strobbe, Nadja; Taylor, Lucas; Tkaczyk, Slawek; Tran, Nhan Viet; Uplegger, Lorenzo; Vaandering, Eric Wayne; Vernieri, Caterina; Verzocchi, Marco; Vidal, Richard; Wang, Michael; Weber, Hannsjoerg Artur; Whitbeck, Andrew; Acosta, Darin; Avery, Paul; Bortignon, Pierluigi; Bourilkov, Dimitri; Brinkerhoff, Andrew; Carnes, Andrew; Carver, Matthew; Curry, David; Das, Souvik; Field, Richard D; Furic, Ivan-Kresimir; Konigsberg, Jacobo; Korytov, Andrey; Ma, Peisen; Matchev, Konstantin; Mei, Hualin; Milenovic, Predrag; Mitselmakher, Guenakh; Rank, Douglas; Shchutska, Lesya; Sperka, David; Thomas, Laurent; Wang, Jian; Wang, Sean-Jiun; Yelton, John; Linn, Stephan; Markowitz, Pete; Martinez, German; Rodriguez, Jorge Luis; Ackert, Andrew; Adams, Jordon Rowe; Adams, Todd; Askew, Andrew; Bein, Samuel; Diamond, Brendan; Hagopian, Sharon; Hagopian, Vasken; Johnson, Kurtis F; Khatiwada, Ajeeta; Prosper, Harrison; Santra, Arka; Weinberg, Marc; Baarmand, Marc M; Bhopatkar, Vallary; Colafranceschi, Stefano; Hohlmann, Marcus; Noonan, Daniel; Roy, Titas; Yumiceva, Francisco; Adams, Mark Raymond; Apanasevich, Leonard; Berry, Douglas; Betts, Russell Richard; Bucinskaite, Inga; Cavanaugh, Richard; Evdokimov, Olga; Gauthier, Lucie; Gerber, Cecilia Elena; Hofman, David Jonathan; Kurt, Pelin; O'Brien, Christine; Sandoval Gonzalez, Irving Daniel; Turner, Paul; Varelas, Nikos; Wang, Hui; Wu, Zhenbin; Zakaria, Mohammed; Zhang, Jingyu; Bilki, Burak; Clarida, Warren; Dilsiz, Kamuran; Durgut, Süleyman; Gandrajula, Reddy Pratap; Haytmyradov, Maksat; Khristenko, Viktor; Merlo, Jean-Pierre; Mermerkaya, Hamit; Mestvirishvili, Alexi; Moeller, Anthony; Nachtman, Jane; Ogul, Hasan; Onel, Yasar; Ozok, Ferhat; Penzo, Aldo; Snyder, Christina; Tiras, Emrah; Wetzel, James; Yi, Kai; Anderson, Ian; Blumenfeld, Barry; Cocoros, Alice; Eminizer, Nicholas; Fehling, David; Feng, Lei; Gritsan, Andrei; Maksimovic, Petar; Osherson, Marc; Roskes, Jeffrey; Sarica, Ulascan; Swartz, Morris; Xiao, Meng; Xin, Yongjie; You, Can; Al-bataineh, Ayman; Baringer, Philip; Bean, Alice; Boren, Samuel; Bowen, James; Bruner, Christopher; Castle, James; Forthomme, Laurent; Kenny III, Raymond Patrick; Kropivnitskaya, Anna; Majumder, Devdatta; Mcbrayer, William; Murray, Michael; Sanders, Stephen; Stringer, Robert; Tapia Takaki, Daniel; Wang, Quan; Ivanov, Andrew; Kaadze, Ketino; Khalil, Sadia; Maravin, Yurii; Mohammadi, Abdollah; Saini, Lovedeep Kaur; Skhirtladze, Nikoloz; Toda, Sachiko; Rebassoo, Finn; Wright, Douglas; Anelli, Christopher; Baden, Drew; Baron, Owen; Belloni, Alberto; Calvert, Brian; Eno, Sarah Catherine; Ferraioli, Charles; Gomez, Jaime; Hadley, Nicholas John; Jabeen, Shabnam; Kellogg, Richard G; Kolberg, Ted; Kunkle, Joshua; Lu, Ying; Mignerey, Alice; Ricci-Tam, Francesca; Shin, Young Ho; Skuja, Andris; Tonjes, Marguerite; Tonwar, Suresh C; Abercrombie, Daniel; Allen, Brandon; Apyan, Aram; Barbieri, Richard; Baty, Austin; Bi, Ran; Bierwagen, Katharina; Brandt, Stephanie; Busza, Wit; Cali, Ivan Amos; Demiragli, Zeynep; Di Matteo, Leonardo; Gomez Ceballos, Guillelmo; Goncharov, Maxim; Hsu, Dylan; Iiyama, Yutaro; Innocenti, Gian Michele; Klute, Markus; Kovalskyi, Dmytro; Krajczar, Krisztian; Lai, Yue Shi; Lee, Yen-Jie; Levin, Andrew; Luckey, Paul David; Marini, Andrea Carlo; Mcginn, Christopher; Mironov, Camelia; Narayanan, Siddharth; Niu, Xinmei; Paus, Christoph; Roland, Christof; Roland, Gunther; Salfeld-Nebgen, Jakob; Stephans, George; Sumorok, Konstanty; Tatar, Kaya; Varma, Mukund; Velicanu, Dragos; Veverka, Jan; Wang, Jing; Wang, Ta-Wei; Wyslouch, Bolek; Yang, Mingming; Zhukova, Victoria; Benvenuti, Alberto; Chatterjee, Rajdeep Mohan; Evans, Andrew; Finkel, Alexey; Gude, Alexander; Hansen, Peter; Kalafut, Sean; Kao, Shih-Chuan; Kubota, Yuichi; Lesko, Zachary; Mans, Jeremy; Nourbakhsh, Shervin; Ruckstuhl, Nicole; Rusack, Roger; Tambe, Norbert; Turkewitz, Jared; Acosta, John Gabriel; Oliveros, Sandra; Avdeeva, Ekaterina; Bartek, Rachel; Bloom, Kenneth; Claes, Daniel R; Dominguez, Aaron; Fangmeier, Caleb; Gonzalez Suarez, Rebeca; Kamalieddin, Rami; Kravchenko, Ilya; Malta Rodrigues, Alan; Meier, Frank; Monroy, Jose; Siado, Joaquin Emilo; Snow, Gregory R; Stieger, Benjamin; Alyari, Maral; Dolen, James; George, Jimin; Godshalk, Andrew; Harrington, Charles; Iashvili, Ia; Kaisen, Josh; Kharchilava, Avto; Kumar, Ashish; Parker, Ashley; Rappoccio, Salvatore; Roozbahani, Bahareh; Alverson, George; Barberis, Emanuela; Baumgartel, Darin; Hortiangtham, Apichart; Massironi, Andrea; Morse, David Michael; Nash, David; Orimoto, Toyoko; Teixeira De Lima, Rafael; Trocino, Daniele; Wang, Ren-Jie; Wood, Darien; Bhattacharya, Saptaparna; Hahn, Kristan Allan; Kubik, Andrew; Kumar, Ajay; Low, Jia Fu; Mucia, Nicholas; Odell, Nathaniel; Pollack, Brian; Schmitt, Michael Henry; Sung, Kevin; Trovato, Marco; Velasco, Mayda; Dev, Nabarun; Hildreth, Michael; Hurtado Anampa, Kenyi; Jessop, Colin; Karmgard, Daniel John; Kellams, Nathan; Lannon, Kevin; Marinelli, Nancy; Meng, Fanbo; Mueller, Charles; Musienko, Yuri; Planer, Michael; Reinsvold, Allison; Ruchti, Randy; Smith, Geoffrey; Taroni, Silvia; Wayne, Mitchell; Wolf, Matthias; Woodard, Anna; Alimena, Juliette; Antonelli, Louis; Brinson, Jessica; Bylsma, Ben; Durkin, Lloyd Stanley; Flowers, Sean; Francis, Brian; Hart, Andrew; Hill, Christopher; Hughes, Richard; Ji, Weifeng; Liu, Bingxuan; Luo, Wuming; Puigh, Darren; Winer, Brian L; Wulsin, Howard Wells; Cooperstein, Stephane; Driga, Olga; Elmer, Peter; Hardenbrook, Joshua; Hebda, Philip; Lange, David; Luo, Jingyu; Marlow, Daniel; Medvedeva, Tatiana; Mei, Kelvin; Mooney, Michael; Olsen, James; Palmer, Christopher; Piroué, Pierre; Stickland, David; Tully, Christopher; Zuranski, Andrzej; Malik, Sudhir; Barker, Anthony; Barnes, Virgil E; Folgueras, Santiago; Gutay, Laszlo; Jha, Manoj; Jones, Matthew; Jung, Andreas Werner; Jung, Kurt; Miller, David Harry; Neumeister, Norbert; Shi, Xin; Sun, Jian; Svyatkovskiy, Alexey; Wang, Fuqiang; Xie, Wei; Xu, Lingshan; Parashar, Neeti; Stupak, John; Adair, Antony; Akgun, Bora; Chen, Zhenyu; Ecklund, Karl Matthew; Geurts, Frank JM; Guilbaud, Maxime; Li, Wei; Michlin, Benjamin; Northup, Michael; Padley, Brian Paul; Redjimi, Radia; Roberts, Jay; Rorie, Jamal; Tu, Zhoudunming; Zabel, James; Betchart, Burton; Bodek, Arie; de Barbaro, Pawel; Demina, Regina; Duh, Yi-ting; Ferbel, Thomas; Galanti, Mario; Garcia-Bellido, Aran; Han, Jiyeon; Hindrichs, Otto; Khukhunaishvili, Aleko; Lo, Kin Ho; Tan, Ping; Verzetti, Mauro; Agapitos, Antonis; Chou, John Paul; Contreras-Campana, Emmanuel; Gershtein, Yuri; Gómez Espinosa, Tirso Alejandro; Halkiadakis, Eva; Heindl, Maximilian; Hidas, Dean; Hughes, Elliot; Kaplan, Steven; Kunnawalkam Elayavalli, Raghav; Kyriacou, Savvas; Lath, Amitabh; Nash, Kevin; Saka, Halil; Salur, Sevil; Schnetzer, Steve; Sheffield, David; Somalwar, Sunil; Stone, Robert; Thomas, Scott; Thomassen, Peter; Walker, Matthew; Foerster, Mark; Heideman, Joseph; Riley, Grant; Rose, Keith; Spanier, Stefan; Thapa, Krishna; Bouhali, Othmane; Celik, Ali; Dalchenko, Mykhailo; De Mattia, Marco; Delgado, Andrea; Dildick, Sven; Eusebi, Ricardo; Gilmore, Jason; Huang, Tao; Juska, Evaldas; Kamon, Teruki; Mueller, Ryan; Pakhotin, Yuriy; Patel, Rishi; Perloff, Alexx; Perniè, Luca; Rathjens, Denis; Rose, Anthony; Safonov, Alexei; Tatarinov, Aysen; Ulmer, Keith; Akchurin, Nural; Cowden, Christopher; Damgov, Jordan; De Guio, Federico; Dragoiu, Cosmin; Dudero, Phillip Russell; Faulkner, James; Kunori, Shuichi; Lamichhane, Kamal; Lee, Sung Won; Libeiro, Terence; Peltola, Timo; Undleeb, Sonaina; Volobouev, Igor; Wang, Zhixing; Delannoy, Andrés G; Greene, Senta; Gurrola, Alfredo; Janjam, Ravi; Johns, Willard; Maguire, Charles; Melo, Andrew; Ni, Hong; Sheldon, Paul; Tuo, Shengquan; Velkovska, Julia; Xu, Qiao; Arenton, Michael Wayne; Barria, Patrizia; Cox, Bradley; Goodell, Joseph; Hirosky, Robert; Ledovskoy, Alexander; Li, Hengne; Neu, Christopher; Sinthuprasith, Tutanon; Sun, Xin; Wang, Yanchu; Wolfe, Evan; Xia, Fan; Clarke, Christopher; Harr, Robert; Karchin, Paul Edmund; Lamichhane, Pramod; Sturdy, Jared; Belknap, Donald; Dasu, Sridhara; Dodd, Laura; Duric, Senka; Gomber, Bhawna; Grothe, Monika; Herndon, Matthew; Hervé, Alain; Klabbers, Pamela; Lanaro, Armando; Levine, Aaron; Long, Kenneth; Loveless, Richard; Ojalvo, Isabel; Perry, Thomas; Polese, Giovanni; Ruggles, Tyler; Savin, Alexander; Smith, Nicholas; Smith, Wesley H; Taylor, Devin; Woods, Nathaniel

    2016-01-01

    Measurements of two- and multi-particle angular correlations in pp collisions at $\\sqrt{s} = $ 5, 7, and 13 TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0 pb$^{-1}$ (5 TeV), 6.2 pb$^{-1}$ (7 TeV), and 0.7 pb$^{-1}$ (13 TeV), were collected using the CMS detector at the LHC. The second-order ($v_2$) and third-order ($v_3$) azimuthal anisotropy harmonics of unidentified charged particles, as well as $v_2$ of $\\mathrm{ K_S }^0$ and $\\Lambda/\\overline{\\Lambda}$ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the $v_2$ values of charged hadrons (mostly pions), $\\mathrm{ K_S }^0$, and $\\Lambda/\\overline{\\Lambda}$, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below $p_{\\mathrm{T}} \\approx 2$ GeV/$c$. For 13 TeV data, the $v_2$ signals are also extracted from fou...

  18. Proving the PP-Wave/CFT_2 Duality

    CERN Document Server

    Gava, E; Gava, Edi

    2002-01-01

    We study the duality between IIB string theory on a pp-wave background, arising as a Penrose limit of the $AdS_3 \\times S^3\\times M$, where $M$ is $T^4$ (or $K3$), and the 2D CFT which is given by the ${\\cal N}=(4,4)$ orbifold $(M)^N/S_N$, resolved by a blowing-up mode. After analizying the action of the supercharges on both sides, we establish a correspondence between the states of the two theories. In particular and for the $T^4$ case, we identify both massive and massless oscillators on the pp-wave, with certain classes of excited states in the resolved CFT carrying large $R$-charge $n$. For the former, the excited states involve fractional modes of the generators of the ${\\cal N}=4$ chiral algebra acting on the $Z_n$ ground states. For the latter, they involve, fractional modes of the $U(1)^4_L\\times U(1)^4_R$ super-current algebra acting on the $Z_n$ ground states. By using conformal perturbation theory we compute the leading order correction to the conformal dimensions of the first class of states, due ...

  19. On the spectrum of pp-wave matrix theory

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Nakwoo E-mail: kim@aei.mpg.de; Plefka, Jan E-mail: plefka@aei.mpg.de

    2002-11-04

    We study the spectrum of the recently proposed matrix model of DLCQ M-theory in a parallel plane (pp)-wave background. In contrast to matrix theory in a flat background this model contains mass terms, which lift the flat directions of the potential and renders its spectrum discrete. The supersymmetry algebra of the model groups the energy eigenstates into supermultiplets, whose members differ by fixed amounts of energy in great similarity to the representation of supersymmetry in AdS spaces. There is a unique and exact zero-energy ground state along with a multitude of long and short multiplets of excited states. For large masses the quantum mechanical model may be treated perturbatively and we study the leading order energy shifts of the first excited states up to level two. Most interestingly we uncover a protected short multiplet at level two, whose energies do not receive perturbative corrections. Moreover, we conjecture the existence of an infinite series of similar protected multiplets in the pp-wave matrix model.

  20. The spectroscopy analyses of PpIX by ultrasound irradiation and its sonotoxicity in vitro.

    Science.gov (United States)

    Wang, Pan; Wang, Xiaobing; Zhang, Kun; Gao, Kaili; Song, Ming; Liu, Quanhong

    2013-07-01

    Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in PDT. But until now, little information has been reported about the sono-damage of PpIX in SDT. So, the present study was to investigate changes of PpIX properties before and after different ultrasound treatment, and the potential interactions between PpIX, ultrasound and the irradiated cells. In cell-free system, the absorption and fluorescence spectra of PpIX in different solutions were measured by ultraviolet spectrometer and fluorescence spectrophotometer, respectively. The terephthalic acid dosimetry was applied to evaluate the efficiency of ultrasound cavitation by monitoring hydroxyl radical (OH) production on the thermolysis of H2O in the ultrasound field. In in vitro study, confocal microscopy was applied to detect the sub-cellular localization of PpIX in S180 cells before and after ultrasound exposure. Flow cytometry was used to detect the reactive oxygen species (ROS) generation during PpIX-SDT. MTT assay was performed to evaluate the cell viability of S180 cells after SDT treatment with or without ROS scavengers. The results show that PpIX displayed different spectral patterns in different solutions. PpIX was decomposed by ultrasound exposure as measured by the decreased absorption and fluorescence peak values in RPMI-1640 medium. In addition, the decomposition of PpIX was found to be simultaneously accompanied by OH production with increasing output power from ultrasound generator. PpIX at 1μg/ml significantly enhanced the ultrasound induced cavitation as measured by OH generation, and which was greatly eliminated by NaN3, histidine, mannitol, EDTA and catalase, but not by SOD. The in vitro study indicates more PpIX entered into S180 cells after ultrasound exposure. And, the extra-cellular Pp

  1. Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis.

    Science.gov (United States)

    Colomer-Winter, C; Gaca, A O; Lemos, J A

    2017-07-01

    In Enterococcus faecalis, the regulatory nucleotides pppGpp and ppGpp, collectively, (p)ppGpp, are required for growth in blood, survival within macrophages, and virulence. However, a clear understanding of how (p)ppGpp promotes virulence in E. faecalis and other bacterial pathogens is still lacking. In the host, the essential transition metals iron (Fe) and manganese (Mn) are not readily available to invading pathogens because of a host-driven process called nutritional immunity. Considering its central role in adaptation to nutritional stresses, we hypothesized that (p)ppGpp mediates E. faecalis virulence through regulation of metal homeostasis. Indeed, supplementation of serum with either Fe or Mn restored growth and survival of the Δrel ΔrelQ [(p)ppGpp(0)] strain to wild-type levels. Using a chemically defined medium, we found that (p)ppGpp accumulates in response to either Fe depletion or Mn depletion and that the (p)ppGpp(0) strain has a strong growth requirement for Mn that is alleviated by Fe supplementation. Although inactivation of the nutrient-sensing regulator codY restored some phenotypes of the (p)ppGpp(0) strain, transcriptional analysis showed that the (p)ppGpp/CodY network does not promote transcription of known metal transporters. Interestingly, physiologic and enzymatic investigations suggest that the (p)ppGpp(0) strain requires higher levels of Mn in order to cope with high levels of endogenously produced reactive oxygen species (ROS). Because (p)ppGpp mediates antibiotic persistence and virulence in several bacteria, our findings have broad implications and provide new leads for the development of novel therapeutic and preventive strategies against E. faecalis and beyond. Copyright © 2017 American Society for Microbiology.

  2. Essential roles for Mycobacterium tuberculosis Rel beyond the production of (p)ppGpp.

    Science.gov (United States)

    Weiss, Leslie A; Stallings, Christina L

    2013-12-01

    In Mycobacterium tuberculosis, the stringent response to amino acid starvation is mediated by the M. tuberculosis Rel (RelMtb) enzyme, which transfers a pyrophosphate from ATP to GDP or GTP to synthesize ppGpp and pppGpp, respectively. (p)ppGpp then influences numerous metabolic processes. RelMtb also encodes a second, distinct catalytic domain that hydrolyzes (p)ppGpp into pyrophosphate and GDP or GTP. RelMtb is required for chronic M. tuberculosis infection in mice; however, it is unknown which catalytic activity of RelMtb mediates pathogenesis and whether (p)ppGpp itself is necessary. In order to individually investigate the roles of (p)ppGpp synthesis and hydrolysis during M. tuberculosis pathogenesis, we generated RelMtb point mutants that were either synthetase dead (RelMtb(H344Y)) or hydrolase dead (RelMtb(H80A)). M. tuberculosis strains expressing the synthetase-dead RelMtb(H344Y) mutant did not persist in mice, demonstrating that the RelMtb (p)ppGpp synthetase activity is required for maintaining bacterial titers during chronic infection. Deletion of a second predicted (p)ppGpp synthetase had no effect on pathogenesis, demonstrating that RelMtb was the major contributor to (p)ppGpp production during infection. Interestingly, expression of an allele encoding the hydrolase-dead RelMtb mutant, RelMtb(H80A), that is incapable of hydrolyzing (p)ppGpp but still able to synthesize (p)ppGpp decreased the growth rate of M. tuberculosis and changed the colony morphology of the bacteria. In addition, RelMtb(H80A) expression during acute or chronic M. tuberculosis infection in mice was lethal to the infecting bacteria. These findings highlight a distinct role for RelMtb-mediated (p)ppGpp hydrolysis that is essential for M. tuberculosis pathogenesis.

  3. Fractographic and rheological characterizations of CF/PP-PE-copolymer composites tested in tensile

    Directory of Open Access Journals (Sweden)

    Paula Helena da Silva Cirilo

    Full Text Available Abstract This work shows the fractographic study of fractured surfaces resulted from tensile tests of thermoplastic composites based on poly(propylene-co-ethylene (PP-PE and modified PP-PE copolymers reinforced with continuous carbon fibers (CF. The PP-PE matrix was modified with two agents called AM1 (based on maleic anhydride and AM2 (containing an elastomeric agent, respectively. Three different laminates - CF/PP-PE, CF/PP-PE(AM1 and CF/PP-PE(AM2 - were manufactured. The best tensile strength and elastic modulus results were determined for the CF/PP-PE(AM1 laminate (507.6 ± 11.8 MPa and 54.7 ± 2.4 GPa, respectively. These results show that the AM1 agent contributed to increase the physicochemical interaction between the CF and the PP-PE matrix. This condition provided a better loading transfer from matrix to the reinforcement. Scanning electron microscopy analyses of the fracture surfaces show the fractographic aspects of the samples and allow evaluating the fiber/matrix-interfacial adhesion. Poor adhesion is observed for the CF/PP-PE and CF/PP-PE(AM2 laminates with the presence of fiber impressions on the polymer rich regions and fiber surfaces totally unprotected of polymer matrix. On the other side, a more consistent adhesion is observed for the CF/PP-PE(AM1 laminate. This result is in agreement with the tensile test data and show the presence of a good interaction between the laminate constituents. The correlation of the mechanical and fractographic results with the curves of complex viscosity versus temperature of the studied polymer matrices shows that the matrix viscosity did not affect the wettability of the reinforcement.

  4. 共聚PP/POE共混物流变行为的研究%Study on the rheological behavior of iPP/POE blends

    Institute of Scientific and Technical Information of China (English)

    王海平; 王炜; 胡国胜; 王标兵

    2009-01-01

    采用XLY-Ⅱ型毛细管流变仪研究了共聚聚丙烯(iPP)、乙烯-辛烯共聚物(POE)及其共混物的流变特性.实验结果表明,PP/POE共混物的最佳加工温度为180℃.iPP/POE共混物熔体均为假塑性流体,呈现出切力变稀现象.PP/POE复合材料的表观黏度与粘流活化能均随着POE含量的增加而减小.

  5. Influence of the use of organoclays on the morphology of PP/EPDM blends; Influencia da utilizacao de argilas organofilicas na morfologia de misturas PP/EPDM

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, K.R.M.; Andrade, D.L.A.C.S.; Raposo, C.M.O.; Silva, S.M.L., E-mail: suedina@dema.ufcg.edu.br [Universidade Federal de Campina Grande (UFCG/UAEMa), PB (Brazil). Unidade Academica de Engenharia de Materiais

    2012-07-01

    This study evaluated the influence of different organoclays on morphology of PP/EPDM blends. Two organobentonite (MPH and MPTH), provided by Laboratory of physical chemistry of the Academic Unit of Mining and Geology/UFCG/Campina Grande/PB and a montmorillonite (Cloisite 20A - C20A), provided by Southern Clay Products (Texas/USA) were added to the PP/EPDM polymer blend in order to obtain nanocomposites containing 1 phr of organoclay. The blends of PP/EPDM/organoclay were prepared by melt intercalation process, in an internal mixer coupled to the Haake Torque Rheometer, operating at 180 ° C and 50 rpm for 15min. The samples were characterized by X-ray diffraction and scanning electron microscopy. The results show that the type of organoclay modified the morphology of PP/EPDM blends. (author)

  6. How Accurately Can we count the number of $pp \\to ZX$ and $pp \\to WX$ events using decays to electrons

    CERN Document Server

    Dissertori, Günther; Ehlers, Jan; Holzner, André

    2006-01-01

    This note describes an analysis of the reaction pp -> ZX and pp -> WX with Z and W decays to electrons, using the full CMS detector simulation and event reconstruction chain. Inclusive Z and W events with their decays to electrons are selected with robust and essentially background-free criteria. The aim of this analysis is to define some baseline selection such that the potential uncertainties from known detector inhomogeneities can be determined. In absence of sufficiently large di-jet event samples, no detailed background studies could be performed. However, it is known from previous CMS studies that the proposed selection criteria are rather insensitive to background and the "early" miscalibrations. This robust selection can thus be considered as especially useful for the CMS startup phase. Keeping these shortcomings in mind, a Z selection efficiency of about 60% is obtained, if the Z decay products end up within the barrel ECAL acceptance. The corresponding efficiency for W's is about 25%. Gaps between t...

  7. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

    Science.gov (United States)

    Connarn, Jamie N; Assimon, Victoria A; Reed, Rebecca A; Tse, Eric; Southworth, Daniel R; Zuiderweg, Erik R P; Gestwicki, Jason E; Sun, Duxin

    2014-01-31

    Protein phosphatase 5 (PP5) is auto-inhibited by intramolecular interactions with its tetratricopeptide repeat (TPR) domain. Hsp90 has been shown to bind PP5 to activate its phosphatase activity. However, the functional implications of binding Hsp70 to PP5 are not yet clear. In this study, we find that both Hsp90 and Hsp70 bind to PP5 using a luciferase fragment complementation assay. A fluorescence polarization assay shows that Hsp90 (MEEVD motif) binds to the TPR domain of PP5 almost 3-fold higher affinity than Hsp70 (IEEVD motif). However, Hsp70 binding to PP5 stimulates higher phosphatase activity of PP5 than the binding of Hsp90. We find that PP5 forms a stable 1:1 complex with Hsp70, but the interaction appears asymmetric with Hsp90, with one PP5 binding the dimer. Solution NMR studies reveal that Hsc70 and PP5 proteins are dynamically independent in complex, tethered by a disordered region that connects the Hsc70 core and the IEEVD-TPR contact area. This tethered binding is expected to allow PP5 to carry out multi-site dephosphorylation of Hsp70-bound clients with a range of sizes and shapes. Together, these results demonstrate that Hsp70 recruits PP5 and activates its phosphatase activity which suggests dual roles for PP5 that might link chaperone systems with signaling pathways in cancer and development.

  8. Alarmone ppGpp and its role in the environmental adaptations of microorganisms%信号分子ppGpp与微生物环境适应性

    Institute of Scientific and Technical Information of China (English)

    卢文珺; 王金文; 徐俊

    2012-01-01

    微生物能感知环境胁迫信号,通过触发严谨反应对生长速率进行调节,并通过一系列代谢调控,使细胞能在不利环境中生存.高度磷酸化的鸟苷四/五磷酸ppGpp/pppGpp(简称ppGpp)作为信号分子对微生物生理具有广泛的调节作用,至今仍是微生物学研究热点之一.ppGpp对于微生物适应高温、高压等环境起到了积极的作用.综述了信号分子ppGpp合成降解机制及其调控微生物适应性方面的研究进展.%When microorganism confronted with unfavorable environment, it can perceive the stress signal and start stringent response quickly to make bacteria more adaptive to all kinds of environment. The guanosine tetraphosphate ppGpp is the most celebrated alarmone to trigger the gene regulation for environmental adaptation according to its physiological status in prokaryote. ppGpp plays an active role especially in extreme environment adaptation, i.e. stress response to high temperature, high pressure et al. This paper reviews the mechanism of ppGpp regulation and the recent progress on the causal relationship between ppGpp and various environmental adaptations.

  9. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    J. Hinloopen (Jeroen); R. Wagenvoort (Rien); J.G.M. van Marrewijk (Charles)

    2008-01-01

    textabstractWe propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot

  10. Evaluation of PpIX formation in Cervical Intraepithelial Neoplasia I (CIN) using widefield fluorescence images

    Science.gov (United States)

    Carbinatto, Fernanda M.; Inada, Natalia M.; Fortunato, Thereza C.; Lombardi, Welington; da Silva, Eduardo V.; Vollet Filho, José D.; Kurachi, Cristina; Pratavieira, Sebastião.; Bagnato, Vanderlei S.

    2016-03-01

    Optical techniques has been described as auxiliary technology for screening of neoplasia because shows the potential for tissues differentiation in real-time and it is a noninvasive detection and safe. However, only endogenous fluorophores presents the lesion may be insufficient and needed of the administration of the fluorophores synthesized, such as, precursor molecule of protoporphyrin IX (PpIX) induced by 5- aminolevulinic acid and your derivatives. Topical application of methylaminolevulinate (MAL), induces formation of the endogenous photosensitizer, PpIX in tissues where carcinogenesis has begun. The PpIX tend to accumulate in premalignant and malignant tissues and the illumination with light with appropriate wavelength beginning to excitation of PpIX fluorescence, which helps to localize PpIX-rich areas and identify potentially malignant tissues. The aim of the study is to evaluate the production of PpIX in the cervix with CIN I through of the fluorescence images captured after 1 hour of cream application. It was possible to visualize PpIX fluorescence in cervix and it was possible to observe the selectivity in fluorescence in squamous-columnar junction, which a pre-cancerous condition (CIN) and usually is localized. Through the image processing it was possible to quantify the increase of red fluorescence. For the CIN I the increase of red fluorescence was approximately of 4 times indicating a good PpIX formation.

  11. Azimuthal correlations in Pb--Pb and pp collisions measured with the ALICE detector

    DEFF Research Database (Denmark)

    Zhou, You; Collaboration, for the ALICE

    2012-01-01

    We present results from the measurements of azimuthal correlations of charged particles in $\\sqrt{s_{_{NN}}}$ = 2.76 TeV Pb--Pb collisions and $\\sqrt{s_{_{NN}}}$ = 7 TeV pp collisions. In addition, the comparison of the experimental measurements in pp collisions with those from Pythia and Phojet...

  12. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    Hinloopen, Jeroen; Wagenvoort, Rien; Marrewijk, van Charles

    2008-01-01

    We propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot that allows

  13. AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.

    Science.gov (United States)

    Xu, Feng; Previti, Mary Lou; Nieman, Marvin T; Davis, Judianne; Schmaier, Alvin H; Van Nostrand, William E

    2009-04-29

    The amyloid beta-protein precursor (AbetaPP) is best recognized as the precursor to the Abeta peptide that accumulates in the brains of patients with Alzheimer's disease, but less is known about its physiological functions. Isoforms of AbetaPP that contain a Kunitz-type serine proteinase inhibitor (KPI) domain are expressed in brain and, outside the CNS, in circulating blood platelets. Recently, we showed that KPI-containing forms of AbetaPP regulates cerebral thrombosis in vivo (Xu et al., 2005, 2007). Amyloid precursor like protein-2 (APLP2), a closely related homolog to AbetaPP, also possesses a highly conserved KPI domain. Virtually nothing is known of its function. Here, we show that APLP2 also regulates cerebral thrombosis risk. Recombinant purified KPI domains of AbetaPP and APLP2 both inhibit the plasma clotting in vitro. In a carotid artery thrombosis model, both AbetaPP(-/-) and APLP2(-/-) mice exhibit similar significantly shorter times to vessel occlusion compared with wild-type mice indicating a prothrombotic phenotype. Similarly, in an experimental model of intracerebral hemorrhage, both AbetaPP(-/-) and APLP2(-/-) mice produce significantly smaller hematomas with reduced brain hemoglobin content compared with wild-type mice. Together, these results indicate that AbetaPP and APLP2 share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury.

  14. Evidence for CP violation in B+ → ppK+ decays.

    Science.gov (United States)

    Aaij, R; Adeva, B; Adinolfi, M; Affolder, A; Ajaltouni, Z; Akar, S; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves, A A; Amato, S; Amerio, S; Amhis, Y; An, L; Anderlini, L; Anderson, J; Andreassen, R; Andreotti, M; Andrews, J E; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Baalouch, M; Bachmann, S; Back, J J; Badalov, A; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Batozskaya, V; Battista, V; Bay, A; Beaucourt, L; Beddow, J; Bedeschi, F; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Bencivenni, G; Benson, S; Benton, J; Berezhnoy, A; Bernet, R; Bettler, M-O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blouw, J; Blusk, S; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Borsato, M; Bowcock, T J V; Bowen, E; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brodzicka, J; Brook, N H; Brown, H; Bursche, A; Busetto, G; Buytaert, J; Cadeddu, S; Calabrese, R; Calvi, M; Calvo Gomez, M; Campana, P; Campora Perez, D; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cassina, L; Castillo Garcia, L; Cattaneo, M; Cauet, Ch; Cenci, R; Charles, M; Charpentier, Ph; Chefdeville, M; Chen, S; Cheung, S-F; Chiapolini, N; Chrzaszcz, M; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coco, V; Cogan, J; Cogneras, E; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Coquereau, S; Corti, G; Corvo, M; Counts, I; Couturier, B; Cowan, G A; Craik, D C; Cruz Torres, M; Cunliffe, S; Currie, R; D'Ambrosio, C; Dalseno, J; David, P; David, P N Y; Davis, A; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Silva, W; De Simone, P; Decamp, D; Deckenhoff, M; Del Buono, L; Déléage, N; Derkach, D; Deschamps, O; Dettori, F; Di Canto, A; Dijkstra, H; Donleavy, S; Dordei, F; Dorigo, M; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dreimanis, K; Dujany, G; Dupertuis, F; Durante, P; Dzhelyadin, R; Dziurda, A; Dzyuba, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; Eisenhardt, S; Eitschberger, U; Ekelhof, R; Eklund, L; El Rifai, I; Elsasser, Ch; Ely, S; Esen, S; Evans, H-M; Evans, T; Falabella, A; Färber, C; Farinelli, C; Farley, N; Farry, S; Fay, Rf; Ferguson, D; Fernandez Albor, V; Ferreira Rodrigues, F; Ferro-Luzzi, M; Filippov, S; Fiore, M; Fiorini, M; Firlej, M; Fitzpatrick, C; Fiutowski, T; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Fu, J; Furfaro, E; Gallas Torreira, A; Galli, D; Gallorini, S; Gambetta, S; Gandelman, M; Gandini, P; Gao, Y; García Pardiñas, J; Garofoli, J; Garra Tico, J; Garrido, L; Gaspar, C; Gauld, R; Gavardi, L; Gavrilov, G; Gersabeck, E; Gersabeck, M; Gershon, T; Ghez, Ph; Gianelle, A; Giani', S; Gibson, V; Giubega, L; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gotti, C; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Griffith, P; Grillo, L; Grünberg, O; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hall, S; Hamilton, B; Hampson, T; Han, X; Hansmann-Menzemer, S; Harnew, N; Harnew, S T; Harrison, J; He, J; Head, T; Heijne, V; Hennessy, K; Henrard, P; Henry, L; Hernando Morata, J A; van Herwijnen, E; Heß, M; Hicheur, A; Hill, D; Hoballah, M; Hombach, C; Hulsbergen, W; Hunt, P; Hussain, N; Hutchcroft, D; Hynds, D; Idzik, M; Ilten, P; Jacobsson, R; Jaeger, A; Jalocha, J; Jans, E; Jaton, P; Jawahery, A; Jing, F; John, M; Johnson, D; Jones, C R; Joram, C; Jost, B; Jurik, N; Kaballo, M; Kandybei, S; Kanso, W; Karacson, M; Karbach, T M; Karodia, S; Kelsey, M; Kenyon, I R; Ketel, T; Khanji, B; Khurewathanakul, C; Klaver, S; Klimaszewski, K; Kochebina, O; Kolpin, M; Komarov, I; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kucewicz, W; Kucharczyk, M; Kudryavtsev, V; Kurek, K; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanfranchi, G; Langenbruch, C; Langhans, B; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J-P; Lefèvre, R; Leflat, A; Lefrançois, J; Leo, S; Leroy, O; Lesiak, T; Leverington, B; Li, Y; Likhomanenko, T; Liles, M; Lindner, R; Linn, C; Lionetto, F; Liu, B; Lohn, S; Longstaff, I; Lopes, J H; Lopez-March, N; Lowdon, P; Lu, H; Lucchesi, D; Luo, H; Lupato, A; Luppi, E; Lupton, O; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Malde, S; Malinin, A; Manca, G; Mancinelli, G; Maratas, J; Marchand, J F; Marconi, U; Marin Benito, C; Marino, P; Märki, R; Marks, J; Martellotti, G; Martens, A; Martín Sánchez, A; Martinelli, M

    2014-10-01

    Three-body B+ → ppK+ and B(+) → ppπ(+) decays are studied using a data sample corresponding to an integrated luminosity of 3.0 fb(-1) collected by the LHCb experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV. Evidence of CP violation in the B(+) → ppK(+) decay is found in regions of the phase space, representing the first measurement of this kind for a final state containing baryons. Measurements of the forward-backward asymmetry of the light meson in the pp rest frame yield A(FB)(ppK(+),m(pp)<2.85 GeV/c(2)) = 0.495 ± 0.012 (stat) ± 0.007 (syst) and A(FB)(ppπ(+),m(pp) <2.85 GeV/c(2)) = -0.409 ± 0.033 (stat) ± 0.006 (syst). In addition, the branching fraction of the decay B(+) → Λ(1520)p is measured to be B(B(+) → Λ(1520)p) = (3.15 ± 0.48 (stat) ± 0.07 (syst) ± 0.26 (BF)) × 10(-7), where BF denotes the uncertainty on secondary branching fractions.

  15. PLA and PP Composite Nonwoven with Antimicrobial Activity for Filtration Applications

    Directory of Open Access Journals (Sweden)

    Marta Łatwińska

    2016-01-01

    Full Text Available The PLA (50% wt./PP (50% wt., PLA (47.5% wt./PP (47.5% wt./paraffin (5% wt., and PLA (47.25% wt./PP (47.25% wt./paraffin (5% wt./CuO·SiO2 (0.5% wt. composite nonwovens were obtained in one-step process by using the melt-blown technique. Thermal properties (by the DSC method, physicomechanical parameters, specific surface area, the structure (by the SEM method, the elemental analysis (by the EDS method, and susceptibility to hydrolytic degradation (in alkaline and neutral media were studied for all the obtained nonwovens. The antimicrobial properties of the composite nonwovens were determined by using dynamic contact conditions method, with three kinds of microorganisms applied. The DSC analysis of nonwovens revealed that the mixing of PLA and PP caused the decrease in homogeneity of both polymers, as well as a considerable increase in the PLA crystallization enthalpy. The paraffin and CuO·SiO2 addition to PLA/PP nonwoven generally improved the filtration properties and downgraded tensile strength. Among all the tested composite nonwovens, the PLA/PP/paraffin/CuO·SiO2 was the most and the PLA/PP/paraffin was the least susceptible to hydrolytic degradation in both media used in the study. The PLA/PP/paraffin/CuO·SiO2 composite nonwoven revealed strong antibacterial activity and slight activity against the yeast.

  16. Splitting function in pp and PbPb collisions at 5.02 TeV

    CERN Document Server

    CMS Collaboration

    2016-01-01

    splitting is observed to be modified towards a more imbalanced fraction in central PbPb collisions compared to peripheral PbPb and pp collisions. In addition, the measurement in pp collisions is compared to the prediction of the splitting function from the {\\tt PYTHIA} and {\\tt HERWIG} event generators.

  17. Two-graviton interaction in pp-wave background in Matrix theory and Supergravity

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hok Kong E-mail: hok@theory.caltech.edu; Wu Xinkai E-mail: xinkaiwu@theory.caltech.edu

    2003-08-18

    We compute the two-body one-loop effective action for the Matrix theory in the pp-wave background, and compare it to the effective action on the Supergravity side in the same background. Agreement is found for the effective actions on both sides. This points to the existence of a supersymmetric nonrenormalization theorem in the pp-wave background.

  18. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    J. Hinloopen (Jeroen); R. Wagenvoort (Rien); J.G.M. van Marrewijk (Charles)

    2008-01-01

    textabstractWe propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot

  19. A K-sample Homogeneity Test based on the Quantification of the p-p Plot

    NARCIS (Netherlands)

    Hinloopen, Jeroen; Wagenvoort, Rien; Marrewijk, van Charles

    2008-01-01

    We propose a quantification of the p-p plot that assigns equal weight to all distances between the respective distributions: the surface between the p-p plot and the diagonal. This surface is labelled the Harmonic Weighted Mass (HWM) index. We introduce the diagonal-deviation (d-d) plot that allows

  20. Molecular mechanism and evolution of guanylate kinase regulation by (p)ppGpp.

    Science.gov (United States)

    Liu, Kuanqing; Myers, Angela R; Pisithkul, Tippapha; Claas, Kathy R; Satyshur, Kenneth A; Amador-Noguez, Daniel; Keck, James L; Wang, Jue D

    2015-02-19

    The nucleotide (p)ppGpp mediates bacterial stress responses, but its targets and underlying mechanisms of action vary among bacterial species and remain incompletely understood. Here, we characterize the molecular interaction between (p)ppGpp and guanylate kinase (GMK), revealing the importance of this interaction in adaptation to starvation. Combining structural and kinetic analyses, we show that (p)ppGpp binds the GMK active site and competitively inhibits the enzyme. The (p)ppGpp-GMK interaction prevents the conversion of GMP to GDP, resulting in GMP accumulation upon amino acid downshift. Abolishing this interaction leads to excess (p)ppGpp and defective adaptation to amino acid starvation. A survey of GMKs from phylogenetically diverse bacteria shows that the (p)ppGpp-GMK interaction is conserved in members of Firmicutes, Actinobacteria, and Deinococcus-Thermus, but not in Proteobacteria, where (p)ppGpp regulates RNA polymerase (RNAP). We propose that GMK is an ancestral (p)ppGpp target and RNAP evolved more recently as a direct target in Proteobacteria.

  1. ppGpp is the major source of growth rate control in E. coli.

    Science.gov (United States)

    Potrykus, Katarzyna; Murphy, Helen; Philippe, Nadège; Cashel, Michael

    2011-03-01

    It is widely accepted that the DNA, RNA and protein content of Enterobacteriaceae is regulated as a function of exponential growth rates; macromolecular content increases with faster growth regardless of specific composition of the growth medium. This phenomenon, called growth rate control, primarily involves regulation of ribosomal RNA and ribosomal protein synthesis. However, it was uncertain whether the global regulator ppGpp is the major determinant for growth rate control. Therefore, here we re-evaluate the effect of ppGpp on macromolecular content for different balanced growth rates in defined media. We find that when ppGpp is absent, RNA/protein and RNA/DNA ratios are equivalent in fast and slow growing cells. Moreover, slow growing ppGpp-deficient cells with increased RNA content, display a normal ribosomal subunit composition although polysome content is reduced when compared with fast growing wild-type cells. From this we conclude that growth rate control does not occur in the absence of ppGpp. Also, artificial elevation of ppGpp or introduction of stringent RNA polymerase mutants in ppGpp-deficient cells restores this control. We believe these findings strongly argue in favour of ppGpp and against redundant regulation of growth rate control by other factors in Escherichia coli and other enteric bacteria.

  2. ppGpp inhibits peptide elongation cycle of chloroplast translation system in vitro.

    Science.gov (United States)

    Nomura, Yuhta; Takabayashi, Taito; Kuroda, Hiroshi; Yukawa, Yasushi; Sattasuk, Kwanchanok; Akita, Mitsuru; Nozawa, Akira; Tozawa, Yuzuru

    2012-01-01

    Chloroplasts possess common biosynthetic pathways for generating guanosine 3',5'-(bis)pyrophosphate (ppGpp) from GDP and ATP by RelA-SpoT homolog enzymes. To date, several hypothetical targets of ppGpp in chloroplasts have been suggested, but they remain largely unverified. In this study, we have investigated effects of ppGpp on translation apparatus in chloroplasts by developing in vitro protein synthesis system based on an extract of chloroplasts isolated from pea (Pisum sativum). The chloroplast extracts showed stable protein synthesis activity in vitro, and the activity was sensitive to various types of antibiotics. We have demonstrated that ppGpp inhibits the activity of chloroplast translation in dose-effective manner, as does the toxic nonhydrolyzable GTP analog guanosine 5'-(β,γ-imido)triphosphate (GDPNP). We further examined polyuridylic acid-directed polyphenylalanine synthesis as a measure of peptide elongation activity in the pea chloroplast extract. Both ppGpp and GDPNP as well as antibiotics, fusidic acid and thiostrepton, inhibited the peptide elongation cycle of the translation system, but GDP in the similar range of the tested ppGpp concentration did not affect the activity. Our results thus show that ppGpp directly affect the translation system of chloroplasts, as they do that of bacteria. We suggest that the role of the ppGpp signaling system in translation in bacteria is conserved in the translation system of chloroplasts.

  3. Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach.

    Directory of Open Access Journals (Sweden)

    Koyuki Kondo

    Full Text Available Upon desiccation, some tardigrades enter an ametabolic dehydrated state called anhydrobiosis and can survive a desiccated environment in this state. For successful transition to anhydrobiosis, some anhydrobiotic tardigrades require pre-incubation under high humidity conditions, a process called preconditioning, prior to exposure to severe desiccation. Although tardigrades are thought to prepare for transition to anhydrobiosis during preconditioning, the molecular mechanisms governing such processes remain unknown. In this study, we used chemical genetic approaches to elucidate the regulatory mechanisms of anhydrobiosis in the anhydrobiotic tardigrade, Hypsibius dujardini. We first demonstrated that inhibition of transcription or translation drastically impaired anhydrobiotic survival, suggesting that de novo gene expression is required for successful transition to anhydrobiosis in this tardigrade. We then screened 81 chemicals and identified 5 chemicals that significantly impaired anhydrobiotic survival after severe desiccation, in contrast to little or no effect on survival after high humidity exposure only. In particular, cantharidic acid, a selective inhibitor of protein phosphatase (PP 1 and PP2A, exhibited the most profound inhibitory effects. Another PP1/PP2A inhibitor, okadaic acid, also significantly and specifically impaired anhydrobiotic survival, suggesting that PP1/PP2A activity plays an important role for anhydrobiosis in this species. This is, to our knowledge, the first report of the required activities of signaling molecules for desiccation tolerance in tardigrades. The identified inhibitory chemicals could provide novel clues to elucidate the regulatory mechanisms underlying anhydrobiosis in tardigrades.

  4. Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach.

    Science.gov (United States)

    Kondo, Koyuki; Kubo, Takeo; Kunieda, Takekazu

    2015-01-01

    Upon desiccation, some tardigrades enter an ametabolic dehydrated state called anhydrobiosis and can survive a desiccated environment in this state. For successful transition to anhydrobiosis, some anhydrobiotic tardigrades require pre-incubation under high humidity conditions, a process called preconditioning, prior to exposure to severe desiccation. Although tardigrades are thought to prepare for transition to anhydrobiosis during preconditioning, the molecular mechanisms governing such processes remain unknown. In this study, we used chemical genetic approaches to elucidate the regulatory mechanisms of anhydrobiosis in the anhydrobiotic tardigrade, Hypsibius dujardini. We first demonstrated that inhibition of transcription or translation drastically impaired anhydrobiotic survival, suggesting that de novo gene expression is required for successful transition to anhydrobiosis in this tardigrade. We then screened 81 chemicals and identified 5 chemicals that significantly impaired anhydrobiotic survival after severe desiccation, in contrast to little or no effect on survival after high humidity exposure only. In particular, cantharidic acid, a selective inhibitor of protein phosphatase (PP) 1 and PP2A, exhibited the most profound inhibitory effects. Another PP1/PP2A inhibitor, okadaic acid, also significantly and specifically impaired anhydrobiotic survival, suggesting that PP1/PP2A activity plays an important role for anhydrobiosis in this species. This is, to our knowledge, the first report of the required activities of signaling molecules for desiccation tolerance in tardigrades. The identified inhibitory chemicals could provide novel clues to elucidate the regulatory mechanisms underlying anhydrobiosis in tardigrades.

  5. Evaluation of the effect of the incorporation of rubber tire waste particles on the properties of PP, HIPS and PP/HIPS matrices

    Directory of Open Access Journals (Sweden)

    Larissa Stieven Montagna

    2013-01-01

    Full Text Available In recent years, the consumption of plastics has been increasing and as consequence, the waste generated has also increased. Rubber tire (RT waste is another residue which causes significant problems to society. In view of the considerable amounts of RT waste generated, this study aimed to evaluate the influence of the incorporation of RT particles into post-consumer thermoplastic matrices such as polypropylene (PP, high impact polystyrene (HIPS and PP/HIPS blends and the modification of the physical, morphological, rheological and mechanical properties. The particle sizes of the RT used were <500 and 500-1000 μm. The RT content was 10% w/w and the weight ratio for the PP/HIPS blend was 4/1, with processing by injection molding. The results showed that the smaller (500 μm particle size led to a decrease in the melt flow rate (MFR of the PP/RT composites (increased viscosity and an increase for the HIPS/RT composites. On the other hand, the larger particles (1000 μm led to a decrease in the mechanical performance of the PP/RT and HIPS/RT blends when compared with the neat polymers (PP and HIPS post-consumer. The observed decrease in the mechanical properties of these composites was due to weak filler/matrix interactions, which can be visualized in images by scanning electron microscopy (SEM of the fracture surface after tensile testing.

  6. 微发泡PP/云母粉复合材料的发泡行为%Foaming Behavior of Microfoam PP/Mica Composite

    Institute of Scientific and Technical Information of China (English)

    龚维; 丁彤; 何颖; 朱建华; 何力

    2011-01-01

    采用化学发泡法,以异相成核理论为基础,研究不同含量云母粉对PP/云母粉复合材料发泡行为的影响,制备了微发泡PP/云母粉复合材料.结果表明:随云母粉含量的增加,泡孔平均直径逐渐减小,泡孔密度逐渐增加.云母粉质量含量为8%时,可得到泡孔直径22.1 μm左右、泡孔密度接近2.7×107的微发泡聚丙烯材料,可以作为聚丙烯发泡的良好发泡体系.%Effect of different content mica on foaming behavior of microfoam PP/Mica composite was studied by heterogeneous nucleation theory.Microfoam PP/Mica composite was prepared.The results indicated that with the increasing of mica content, cell diameter decreased gradually, cell density increased gradually.The polypropylene foam with cells about 22.1 μm in size and cell density of near 2.7 × 107cells/cm3 was produced by the use of PP/mica foaming system with 8wt % content,there was ideal foaming system in PP composite.

  7. Suggested Involvement of PP1/PP2A Activity and De Novo Gene Expression in Anhydrobiotic Survival in a Tardigrade, Hypsibius dujardini, by Chemical Genetic Approach

    Science.gov (United States)

    Kondo, Koyuki; Kubo, Takeo; Kunieda, Takekazu

    2015-01-01

    Upon desiccation, some tardigrades enter an ametabolic dehydrated state called anhydrobiosis and can survive a desiccated environment in this state. For successful transition to anhydrobiosis, some anhydrobiotic tardigrades require pre-incubation under high humidity conditions, a process called preconditioning, prior to exposure to severe desiccation. Although tardigrades are thought to prepare for transition to anhydrobiosis during preconditioning, the molecular mechanisms governing such processes remain unknown. In this study, we used chemical genetic approaches to elucidate the regulatory mechanisms of anhydrobiosis in the anhydrobiotic tardigrade, Hypsibius dujardini. We first demonstrated that inhibition of transcription or translation drastically impaired anhydrobiotic survival, suggesting that de novo gene expression is required for successful transition to anhydrobiosis in this tardigrade. We then screened 81 chemicals and identified 5 chemicals that significantly impaired anhydrobiotic survival after severe desiccation, in contrast to little or no effect on survival after high humidity exposure only. In particular, cantharidic acid, a selective inhibitor of protein phosphatase (PP) 1 and PP2A, exhibited the most profound inhibitory effects. Another PP1/PP2A inhibitor, okadaic acid, also significantly and specifically impaired anhydrobiotic survival, suggesting that PP1/PP2A activity plays an important role for anhydrobiosis in this species. This is, to our knowledge, the first report of the required activities of signaling molecules for desiccation tolerance in tardigrades. The identified inhibitory chemicals could provide novel clues to elucidate the regulatory mechanisms underlying anhydrobiosis in tardigrades. PMID:26690982

  8. Manifestation of the $P$-wave diproton resonance in single-pion production in $pp$ collisions

    CERN Document Server

    Platonova, M N

    2016-01-01

    It is demonstrated that many important features of single-pion production in $pp$ collisions at intermediate energies ($T_p \\simeq 400$-$800$ MeV) can naturally be explained by supposing excitation of intermediate diproton resonances in $pp$ channels ${}^1D_2$, ${}^3F_3$ and ${}^3P_2$, in addition to conventional mechanisms involving an intermediate $\\Delta$-isobar. We predict for the first time the crucial role of the ${}^3P_2$ diproton resonance, found in recent experiments on the single-pion production reaction $pp \\to pp({}^1S_0) \\pi^0$, in reproducing the proper behavior of spin-correlation parameters in the reaction $pp \\to d \\pi^+$ which were poorly described by conventional meson-exchange models to date. The possible quark structure of the $P$-wave diproton resonances is also discussed.

  9. Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS).

    Science.gov (United States)

    Zhan, Xin; Bach, Søren Spanner; Hansen, Nikolaj Lervad; Lunde, Christina; Simonsen, Henrik Toft

    2015-11-01

    The bifunctional diterpene synthase, copalyl diphosphate/kaurene synthase from the moss Physcomitrella patens (PpCPS/KS), catalyses the formation of at least four diterpenes, including ent-beyerene, ent-sandaracopimaradiene, ent-kaur-16-ene, and 16-hydroxy-ent-kaurene. The enzymatic activity has been confirmed through generation of a targeted PpCPS/KS knock-out mutant in P. patens via homologous recombination, through transient expression of PpCPS/KS in Nicotiana benthamiana, and expression of PpCPS/KS in E. coli. GC-MS analysis of the knock-out mutant shows that it lacks the diterpenoids, supporting that all are products of PpCPS/KS as observed in N. benthamiana and E. coli. These results provide additional knowledge of the mechanism of this bifunctional diterpene synthase, and are in line with proposed reaction mechanisms in kaurene biosynthesis.

  10. Development, structure and strength properties of PP/PMMA/FA blends

    Indian Academy of Sciences (India)

    Navin Chand; S R Vashishtha

    2000-04-01

    A new type of flyash filled PP/PMMA blend has been developed. Structural and thermal properties of flyash (FA) filled polypropylene (PP)/polymethyl methacrylate (PMMA) blend system have been determined and analysed. Filled polymer blends were developed on a single screw extruder. Strength and thermal properties of FA filled and unfilled PP/PMMA blends were determined. Addition of flyash imparted dimensional and thermal stability, which has been observed in scanning electron micrographs and in TGA plot. Increase of flyash concentration increased the initial degradation temperature of PP/PMMA blend. The increase of thermal stability has been explained based on increased mechanical interlocking of PP/PMMA chains inside the hollow structure of flyash.

  11. Characterization of cDNA encoding human placental anticoagulant protein (PP4): Homology with the lipocortin family

    Energy Technology Data Exchange (ETDEWEB)

    Grundmann, U.; Abel, K.J.; Bohn, H.; Loebermann, H.; Lottspeich, F.; Kuepper, H. (Research Institutes, Postfach (West Germany))

    1988-06-01

    A cDNA library prepared from human placenta was screened for sequences encoding the placental protein 4 (PP4). PP4 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Partial amino acid sequence information from PP4-derived cyanogen bromide fragments was used to design three oligonucleotide probes for screening the library. From 10{sup 6} independent recombinants, 18 clones were identified that hybridized to all three probes. These 18 recombinants contained cDNA inserts encoding a protein of 320 amino acid residues. In addition to the PP4 cDNA the authors identified 9 other recombinants encoding a protein with considerable similarity (74%) to PP4, which was termed PP4-X. PP4 and PP4-X belong to the lipocortin family, as judged by their homology to lipocortin I and calpactin I.

  12. pp-wave matrix models from point-like gravitons

    Energy Technology Data Exchange (ETDEWEB)

    Lozano, Y. [Departamento de Fisica, Universidad de Oviedo, Av. Calvo Sotelo 18, 33007 Oviedo (Spain); Rodriguez-Gomez, D. [Department of Physics, Princeton University, Princeton, NJ 08540 (United States)

    2007-05-15

    The BFSS Matrix model can be regarded as a theory of coincident M-theory gravitons. In this spirit, we summarize how using the action for coincident gravitons proposed in hep-th/0207199 it is possible to go beyond the linear order approximation of Kabat and Taylor, and to provide a satisfactory microscopical description of giant gravitons in AdS{sub m} x S{sup n} backgrounds. We then show that in the M-theory maximally supersymmetric pp-wave background, the action for coincident gravitons, besides reproducing the BMN Matrix model, predicts a new quadrupolar coupling to the M-theory 6-form potential, which supports the so far elusive fuzzy 5-sphere giant graviton solution. Finally, we discuss similar Matrix models that can be derived in Type II string theories using dualities. (Abstract Copyright [2007], Wiley Periodicals, Inc.)

  13. Pp-wave Matrix Models from Point-like Gravitons

    CERN Document Server

    Lozano, Y; Lozano, Yolanda; Rodriguez-Gomez, Diego

    2007-01-01

    The BFSS Matrix model can be regarded as a theory of coincident M-theory gravitons. In this spirit, we summarize how using the action for coincident gravitons proposed in hep-th/0207199 it is possible to go beyond the linear order approximation of Kabat and Taylor, and to provide a satisfactory microscopical description of giant gravitons in $AdS_m\\times S^n$ backgrounds. We then show that in the M-theory maximally supersymmetric pp-wave background, the action for coincident gravitons, besides reproducing the BMN Matrix model, predicts a new quadrupolar coupling to the M-theory 6-form potential, which supports the so far elusive fuzzy 5-sphere giant graviton solution. Finally, we discuss similar Matrix models that can be derived in Type II string theories using dualities.

  14. VII Workshop Italiano sulla fisica pp a LHC

    Science.gov (United States)

    LHCpp2016 è la settima edizione dell'incontro nazionale sulla fisica p-p a LHC. Questa serie di incontri è nata a Pisa nel 2003 con lo scopo di stimolare lo scambio di idee tra le comunità sperimentali di ATLAS, CMS e LHCB e la comunità teorica. Caratteristica fondamentale di questi incontri è la preparazione di larga parte dei talk in collaborazione tra i vari esperimenti e la comunità teorica. Largo spazio nella preparazione e presentazione dei talk viene dato ai giovani ricercatori. In questa settima edizione, che si tiene di nuovo a Pisa, vogliamo concentrare l'attenzione sulle potenzialità di scoperta offerte dai dati raccolti durante il runII di LHC.

  15. CCK, PYY and PP: the control of energy balance.

    Science.gov (United States)

    Simpson, K; Parker, J; Plumer, J; Bloom, S

    2012-01-01

    The control of food intake consists of neural and hormonal signals between the gut and central nervous system (CNS). Gut hormones such as CCK, PYY and PP signal to important areas in the CNS involved in appetite regulation to terminate a meal. These hormones can act directly via the circulation and activate their respective receptors in the hypothalamus and brainstem. In addition, gut vagal afferents also exist, providing an alternative pathway through which gut hormones can communicate with higher centres through the brainstem. Animal and human studies have demonstrated that peripheral administration of certain gut hormones reduces food intake and leads to weight loss. Gut hormones are therefore potential targets in the development of novel treatments for obesity and analogue therapies are currently under investigation.

  16. Bose-Einstein correlations in pp annihilations at rest

    Energy Technology Data Exchange (ETDEWEB)

    Adler, R.; Alhalel, T.; Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Backenstoss, G.; Bee, C.P.; Behnke, O.; Bennet, J.; Bertin, V.; Bienlein, J.K.; Bloch, P.; Bula, C.; Carlson, P.; Carvalho, J.; Cawley, E.; Charalambous, S.; Chardalas, M.; Chardin, G.; Chertok, M.B.; Danielsson, M.; Cody, A.; Dedoussis, S.; Dejardin, M.; Derre, J.; Dodgson, M.; Dousse, J.C.; Duclos, J.; Ealet, A.; Eckart, B.; Eleftheriadis, C.; Evangelou, I.; Faravel, L.; Fassnacht, P.; Faure, J.L.; Felder, C.; Ferreira-Marques, R.; Fetscher, W.; Fidecaro, M.; Filipcic, A.; Francis, D.; Fry, J.; Fuglesang, C.; Gabathuler, E.; Gamet, R.; Garreta, D.; Geralis, T.; Gerber, H.J.; Go, A.; Gumplinger, P.; Guyot, C.; Harrison, P.F.; Haselden, A.; Hayman, P.J.; Henry-Couannier, F.; Heyes, W.G.; Hollander, R.W.; Jansson, K.; Johner, H.U.; Jon-And, K.; Kerek, A.; Kern, J.; Kettle, P.R.; Kochowski, C.; Kokkas, P.; Kreuger, R.; Lawry, T.; Gac, R. le; Liolios, A.; Machado, E.; Maley, P.; Mandic, I.; Manthos, N.; Marel, G.; M; CPLEAR Collaboration

    1994-09-01

    Two-charged-pion correlations were studied in pp ([yields] 2[pi][sup +]2[pi][sup -] n[pi][sup 0], n [>=] 0) annihilations at rest with the CPLEAR detector at the Low-Energy Antiproton Ring (LEAR). A strong enhancement was found in the production of pairs of like-sign pions with a small value of the relative four-momentum Q, with respect to pairs of unlike-sign pions. The observed enhancement was interpreted as a consequence of the Bose-Einstein symmetrization of the twopion wave function. The data are well represented by a correlation function parametrized as a double-Gaussian; an exponential parametrization is also statistically acceptable. The value of the correlation strength is found to be > 1. The high-quality large data samples together with the ability for K[sup [+-

  17. Rheological and thermal properties of PP-based WPC

    Science.gov (United States)

    Mazzanti, V.; Mollica, F.; El Kissi, N.

    2014-05-01

    Wood Plastic Composite (WPC) has attracted great interest in outdoor building products for the reduced cost and the possibility of using recycled materials. Nevertheless the material shows two problems: the large viscosity due to the presence of high concentrations of filler and the degradation of cellulose during processing The aim of this work was to investigate the rheological and thermal properties of WPC. The material used for the experiments was a commercial PP-based WPC compound, with different concentrations of natural fibers (30, 50, 70% wt.). The thermal properties were studied to check for degradation of natural fibers during the subsequent rheological tests. Analyzing the storage and loss moduli and the complex viscosity curves obtained using a parallel plate rheometer it was possible to observe some features related to the viscoelastic nature of the composite.

  18. Functionalized 2PP structures for the BioPhotonics Workstation

    DEFF Research Database (Denmark)

    Matsuoka, Tomoyo; Nishi, Masayuki; Sakakura, Masaaki

    2011-01-01

    In its standard version, our BioPhotonics Workstation (BWS) can generate multiple controllable counter-propagating beams to create real-time user-programmable optical traps for stable three-dimensional control and manipulation of a plurality of particles. The combination of the platform with micr......In its standard version, our BioPhotonics Workstation (BWS) can generate multiple controllable counter-propagating beams to create real-time user-programmable optical traps for stable three-dimensional control and manipulation of a plurality of particles. The combination of the platform...... with microstructures fabricated by two-photon polymerization (2PP) can lead to completely new methods to communicate with micro- and nano-sized objects in 3D and potentially open enormous possibilities in nano-biophotonics applications. In this work, we demonstrate that the structures can be used as microsensors...

  19. Effect of compatibilizer on non-isothermal crystallization kinetics of PP/r-PET blends%增容剂对PP/r-PET共混物非等温结晶动力学的影响

    Institute of Scientific and Technical Information of China (English)

    周红军; 卢永乐; 何桂銮

    2013-01-01

    The effect of the compatibilizer of glycidyl methacrylate-grafted polypropylene (PP-g-GMA) on the non-isothermal crystallization kinetics of polypropylene (PP)/recycled polyethylene terephthalate (r-PET) blend were investigated by differential scanning calorimetry. The results showed that r-PET had a heterogeneous nucleation effect in PP/r-PET blend system, resulting in an elevation of PP crystallization peak temperature and a decrease in the half-crystallization time of the blend system ; the addition of PP-g-GMA decreased the crystallization temperature of PP/r-PET and increased the half-crstallization time, but depressed the crystallization activation energy of PP.%采用差示扫描量热法研究了增容剂甲基丙烯酸缩水甘油酯接枝聚丙烯(PP-g-GMA)对聚丙烯(PP)/回收聚对苯二甲酸乙二酯(r-PET)共混物的非等温结晶动力学的影响.结果表明:在PP/r-PET共混体系中,r-PET起到异相成核的作用,PP的结晶峰温升高,半结晶时间减少;增容剂PP-g-GMA的加入使PP/r-PET的结晶温度降低,半结晶时间增大,但降低了PP的结晶活化能.

  20. Biochemical analyses of ppGpp effect on adenylosuccinate synthetases, key enzymes in purine biosynthesis in rice.

    Science.gov (United States)

    Nomura, Yuhta; Nozawa, Akira; Tozawa, Yuzuru

    2014-01-01

    The ppGpp-signaling system functions in plant chloroplasts. In bacteria, a negative effect of ppGpp on adenylosuccinate synthetase (AdSS) has been suggested. Our biochemical analysis also revealed rice AdSS homologs are apparently sensitive to ppGpp. However, further investigation clarified that this phenomenon is cancelled by the high substrate affinity to the enzymes, leading to a limited effect of ppGpp on adenylosuccinate synthesis.

  1. 75 FR 78705 - Issuance of Exposure Drafts on Implementation Guidance on the Accounting for the Disposal of G-PP...

    Science.gov (United States)

    2010-12-16

    ... G-PP&E and Implementation Guidance for Estimating the Historical Cost of G-PP&E AGENCY: Federal... Historical Cost of G- PP&E. The Exposure Drafts are available on the FASAB home page http://www.fasab.gov... From the Federal Register Online via the Government Publishing Office FEDERAL ACCOUNTING...

  2. Fabrication of borassus fruit lignocellulose fiber/PP composites and comparison with jute, sisal and coir fibers.

    Science.gov (United States)

    Sudhakara, P; Jagadeesh, Dani; Wang, YiQi; Prasad, C Venkata; Devi, A P Kamala; Balakrishnan, G; Kim, B S; Song, J I

    2013-10-15

    Novel composites based on borassus fruit fine fiber (BFF) and polypropylene (PP) were fabricated with variable fiber composition (5, 10, 15 and 20 wt%) by injection molding. Maleated PP (MAPP) was also used as compatibilizer at 5 wt% for effective fiber-matrix adhesion. FTIR analysis confirms the evidence of a chemical bonding between the fiber and polymeric matrix through esterification in presence of MAPP. The tensile and flexural properties were found to increase with 15 and 10 wt% fiber loadings respectively, and decreased thereafter. Coir, jute and sisal fiber composites were also fabricated with 15 wt% fiber loading under the same conditions as used for BFF/PP composites. It was found that the mechanical properties of BFF (15 wt%)/PP composites were equivalent to jute/PP, sisal/PP and superior to coir/PP composites. Jute/PP and sisal/PP composites showed higher water absorption than BFF/PP and coir/PP composites. These results have demonstrated that the BFF/PP composites can also be an alternative material for composites applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Plasma enhanced modification of TMP fiber and its effect on tensile strength of wood fiber/PP composite

    Science.gov (United States)

    Sangyeob Lee; Todd F. Shupe; Chung Y. Hse

    2009-01-01

    Plasma-assisted surface treatment on thermomechanical pulp (TMP) fiber and polypropylene (PP) film was investigated to obtain interfacial adhesion at the wood fiber and PP interface. A metal plate between electrodes prevented thermal damage to the TMP fiber handsheets and PP film. Oxygen-plasma treatment provided better surface activation on the TMP fiber and...

  4. 78 FR 19194 - P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Science.gov (United States)

    2013-03-29

    ... Bureau of Industry and Security P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying... Division, P&P Computers (``P&P'') was convicted of violating the International Emergency Economic Powers... IEEPA and the Iranian Transactions Regulations by exporting computer and related equipment from...

  5. Research on Melt Rheological Properties of PP/PET Blends%PP/PEG共混体系熔体流变性能研究

    Institute of Scientific and Technical Information of China (English)

    迟长龙; 于翔; 李静静; 徐玲

    2013-01-01

    Polypropylene/polyethylene glycol (PP/PEG) blend was prepared through melting extrusion with PEG as antistatic agents in different proportions. The Theological properties of PP/PEG were analyzed by using rheometer, and the influencing factors on the melt rheological properties of blends, such as the shear rate, concentration of PEG, temperature and so on, were researched. The results show that: PP/PEG blends are the typical pseudoplastic fluid; with the increase of content of PEG, the non-newtonian index increases firstly and then decreases; the value of the viscous flow activation energy increases with increasing the content of the antistatic agent. With the increase of PEG content, the structural viscosity index shows a trend of decreases firstly and then increases. And at the PEG 6% content of PP, the spinnability of the blends is better.%以聚乙二醇(PEG)为抗静电剂,在不同共混比例下与聚丙烯(PP)熔融挤出,用流变仪分析了PP/PEG二元共混体系的流变性能,并深入研究了剪切速率、温度、PEG含量等因素对共混体系熔体流变性能的影响.结果表明:PP/PEG共混体系为典型的假塑性流体;随着PEG含量的增加,非牛顿指数n先增大后减小;黏流活化能随PEG含量的增加而增加;结构黏度指数△η则随PEG含量的增加先减小后增大,且在PEG含量为6%时达到极小值,此时共混体系的可纺性相对较好.

  6. A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease.

    Science.gov (United States)

    Boevink, Petra C; Wang, Xiaodan; McLellan, Hazel; He, Qin; Naqvi, Shaista; Armstrong, Miles R; Zhang, Wei; Hein, Ingo; Gilroy, Eleanor M; Tian, Zhendong; Birch, Paul R J

    2016-01-29

    Plant pathogens deliver effectors to alter host processes. Knowledge of how effectors target and manipulate host proteins is critical to understand crop disease. Here, we show that in planta expression of the RXLR effector Pi04314 enhances leaf colonization by Phytophthora infestans via activity in the host nucleus and attenuates induction of jasmonic and salicylic acid-responsive genes. Pi04314 interacts with three host protein phosphatase 1 catalytic (PP1c) isoforms, causing their re-localization from the nucleolus to the nucleoplasm. Re-localization of PP1c-1 also occurs during infection and is dependent on an R/KVxF motif in the effector. Silencing the PP1c isoforms or overexpression of a phosphatase-dead PP1c-1 mutant attenuates infection, demonstrating that host PP1c activity is required for disease. Moreover, expression of PP1c-1mut abolishes enhanced leaf colonization mediated by in planta Pi04314 expression. We argue that PP1c isoforms are susceptibility factors forming holoenzymes with Pi04314 to promote late blight disease.

  7. [Two-photon excitation fluorescence of 5-ALA induced PpIX in DHL cells].

    Science.gov (United States)

    Huang, Zu-Fang; Chen, Rong; Li, Yong-Zeng; Chen, Guan-Nan; Chen, Xian-Ling; Feng, Shang-Yuan; Jia, Pei-Min

    2008-11-01

    Two-photon fluorescence microscopy is a novel imaging technique, which is primarily sensitive to a specimen's response coming from an in-focus plane, thus has low photo-bleaching and photo-damage to biological samples. 5-ALA induced production of PpIX in DHL cells was excited by 820 nm femtosecond laser; two-photon excitation fluorescence of single cell was obtained in Lambda mode of laser scanning confocal microscope. The specific fluorescence intensity of PpIX which accumulated in DHL cells was measured at 2, 4 and 10 mmol x L(-1) concentration of 5-ALA with different incubation time, which reflected the kinetics of 5-ALA accumulated in DHL cells. Accumulation of PpIX in DHL cells was a dynamic change process. Biphasic alterations of PpIX accumulation were noted: PpIX content enhanced with the increasing time and reached the maximal value around 3 h, however PpIX content decreased in the subsequent incubation time. Results indicate that two-photon fluorescence based on laser scanning microscope can be a useful technology for studying the kinetics of 5-ALA induced PpIX production in DHL cells and other leukemia cells.

  8. Group A PP2Cs evolved in land plants as key regulators of intrinsic desiccation tolerance.

    Science.gov (United States)

    Komatsu, Kenji; Suzuki, Norihiro; Kuwamura, Mayuri; Nishikawa, Yuri; Nakatani, Mao; Ohtawa, Hitomi; Takezawa, Daisuke; Seki, Motoaki; Tanaka, Maho; Taji, Teruaki; Hayashi, Takahisa; Sakata, Yoichi

    2013-01-01

    Vegetative desiccation tolerance is common in bryophytes, although this character has been lost in most vascular plants. The moss Physcomitrella patens survives complete desiccation if treated with abscisic acid (ABA). Group A protein phosphatases type 2C (PP2C) are negative regulators of abscisic acid signalling. Here we show that the elimination of Group A PP2C is sufficient to ensure P. patens survival to full desiccation, without ABA treatment, although its growth is severely hindered. Microarray analysis shows that the Group A PP2C-regulated genes exclusively overlap with genes exhibiting a high level of ABA induction. Group A PP2C disruption weakly affects ABA-activated kinase activity, indicating Group A PP2C action downstream of these kinases in the moss. We propose that Group A PP2C emerged in land plants to repress desiccation tolerance mechanisms, possibly facilitating plants propagation on land, whereas ABA releases the intrinsic desiccation tolerance from Group A PP2C regulation.

  9. The Study on Mechanical Properties of PP/POE Blends and PP/POE/Nano-CaCO3 Composites%PP/POE共混体系及PP/POE/Nano-CaCO3复合体系力学性能的研究

    Institute of Scientific and Technical Information of China (English)

    梁基照; 马文勇

    2010-01-01

    应用双螺杆挤出机制备了聚丙烯(PP)/聚烯烃弹性体(POE)共混体系和PP/POE/纳米碳酸钙(nano CaCO3)复合体系,研究了POE用量及nano-CaCO3对PP冲击性能、拉伸性能及弯曲性能的影响.结果表明,随着POE用量的增加,PP/POE共混体系及PP/POE/nano-CaCO3复合体系的冲击强度明显增加;拉伸强度及拉伸模量、弯曲强度及弯曲模量均减小;断裂伸长率及断裂强度亦减小.此外,与PP/POE共混体系相比,PP/POE/nano-CaCO3复合体系的冲击强度、拉伸强度及拉伸模量、弯曲强度及弯曲模量均优于PP/POE共混体系.

  10. Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.

    Science.gov (United States)

    Steinchen, Wieland; Schuhmacher, Jan S; Altegoer, Florian; Fage, Christopher D; Srinivasan, Vasundara; Linne, Uwe; Marahiel, Mohamed A; Bange, Gert

    2015-10-27

    Nucleotide-based second messengers serve in the response of living organisms to environmental changes. In bacteria and plant chloroplasts, guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) [collectively named "(p)ppGpp"] act as alarmones that globally reprogram cellular physiology during various stress conditions. Enzymes of the RelA/SpoT homology (RSH) family synthesize (p)ppGpp by transferring pyrophosphate from ATP to GDP or GTP. Little is known about the catalytic mechanism and regulation of alarmone synthesis. It also is unclear whether ppGpp and pppGpp execute different functions. Here, we unravel the mechanism and allosteric regulation of the highly cooperative alarmone synthetase small alarmone synthetase 1 (SAS1) from Bacillus subtilis. We determine that the catalytic pathway of (p)ppGpp synthesis involves a sequentially ordered substrate binding, activation of ATP in a strained conformation, and transfer of pyrophosphate through a nucleophilic substitution (SN2) reaction. We show that pppGpp-but not ppGpp-positively regulates SAS1 at an allosteric site. Although the physiological significance remains to be elucidated, we establish the structural and mechanistic basis for a biological activity in which ppGpp and pppGpp execute different functional roles.

  11. Direct binding targets of the stringent response alarmone (p)ppGpp.

    Science.gov (United States)

    Kanjee, Usheer; Ogata, Koji; Houry, Walid A

    2012-09-01

    The Escherichia coli stringent response, mediated by the alarmone ppGpp, is responsible for the reorganization of cellular transcription upon nutritional starvation and other stresses. These transcriptional changes occur mainly as a result of the direct effects of ppGpp and its partner transcription factor DksA on RNA polymerase. An often overlooked feature of the stringent response is the direct targeting of other proteins by ppGpp. Here we review the literature on proteins that are known to bind ppGpp and, based on sequence homology, X-ray crystal structures and in silico docking, we propose new potential protein binding targets for ppGpp. These proteins were found to fall into five main categories: (i) cellular GTPases, (ii) proteins involved in nucleotide metabolism, (iii) proteins involved in lipid metabolism, (iv) general metabolic proteins and (v) PLP-dependent basic aliphatic amino acid decarboxylases. Bioinformatic rationale is provided for expanding the role of ppGpp in regulating the activities of the cellular GTPases. Proteins involved in nucleotide and lipid metabolism and general metabolic proteins provide an interesting set of structurally varied stringent response targets. While the inhibition of some PLP-dependent decarboxylases by ppGpp suggests the existence of cross-talk between the acid stress and stringent response systems.

  12. Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans.

    Science.gov (United States)

    He, Ping; Deng, Cong; Liu, Boyu; Zeng, LingBing; Zhao, Wei; Zhang, Yan; Jiang, XuCheng; Guo, XiaoKui; Qin, JinHong

    2013-11-01

    Alarmone Guanosine 5'-diphosphate (or 5'-triphosphate) 3'-diphosphate [(p)ppGpp] is the key component that globally regulates stringent control in bacteria. There are two homologous enzymes, RelA and SpoT in Escherichia coli, which are responsible for fluctuations in (p)ppGpp concentration inside the cell, whereas there exists only a single RelA/SpoT enzyme in Gram-positive bacteria. We have identified a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans. We show that the relLin gene (LA_3085) encodes a protein that fully complements the relA/spoT double mutants in E. coli. The protein functions as a (p)ppGpp degradase as well as a (p)ppGpp synthase when the cells encounter amino acid stress and deprivation of carbon sources. N-terminus HD and RSD domains of relLin (relLinN ) were observed to restore growth of double mutants of E. coli. Finally, We demonstrate that purified RelLin and RelLinN show high (p)ppGpp synthesis activity in vitro. Taken together, our results suggest that L. interrogans contain a single Rel-like bifunctional protein, RelLin , which plays an important role in maintaining the basal level of (p)ppGpp in the cell potentially contributing to the regulation of bacterial stress response.

  13. Selective and sensitive colorimetric detection of stringent alarmone ppGpp with Fenton-like reagent.

    Science.gov (United States)

    Zheng, Lin Ling; Huang, Cheng Zhi

    2014-12-01

    Stringent alarmone, namely, guanosine 3'-diphosphate-5'-diphosphate (ppGpp), is a global regulator that plays a critical role in the survival, growth, metabolism, and many other vital processes of microorganisms. Because of its structural similarity to normal nucleotides, it is also a challenge for the selective and sensitive detection of ppGpp nowadays. Herein, we developed a colorimetric method for the selective detection of ppGpp by inhibiting the redox reaction between Fenton-like reagent (composed of Fe(3+) and H2O2) with 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS). Owing to the strong coordination affinity between ppGpp and Fe(3+), the chromogenic reaction between ABTS and Fenton-like reagent, occurred in aqueous medium at 37 °C and resulted in a bluish-green solution, which was inhibited with the addition of ppGpp. This phenomenon forms the basis for the colorimetric detection of ppGpp, with a detection limit of 0.19 μM and good selectivity for ppGpp over other nucleotides and anions. Furthermore, the results could be visualized by the naked eye, and the sensitivity of the naked-eye observation could even be further improved with the aid of the introduction of a background color.

  14. Alarmone (p)ppGpp regulates the transition from pathogenicity to mutualism in Photorhabdus luminescens.

    Science.gov (United States)

    Bager, Ragnhild; Roghanian, Mohammad; Gerdes, Kenn; Clarke, David J

    2016-05-01

    The enteric gamma-proteobacterium Photorhabdus luminescens kills a wide range of insects, whilst also maintaining a mutualistic relationship with soil nematodes from the family Heterorhabditis. Pathogenicity is associated with bacterial exponential growth, whilst mutualism is associated with post-exponential (stationary) phase. During post-exponential growth, P. luminescens also elaborates an extensive secondary metabolism, including production of bioluminescence, antibiotics and pigment. However, the regulatory network that controls the expression of this secondary metabolism is not well understood. The stringent response is a well-described global regulatory system in bacteria and mediated by the alarmone (p)ppGpp. In this study, we disrupted the genes relA and spoT, encoding the two predicted (p)ppGpp synthases of P. luminescens TTO1, and we showed that (p)ppGpp is required for secondary metabolism. Moreover, we found the (p)ppGpp is not required for pathogenicity of P. luminescens, but is required for bacterial survival within the insect cadaver. Finally, we showed that (p)ppGpp is required for P. luminescens to support normal nematode growth and development. Therefore, the regulatory network that controls the transition from pathogenicity to mutualism in P. luminescens requires (p)ppGpp. This is the first report outlining a role for (p)ppGpp in controlling the outcome of an interaction between a bacteria and its host.

  15. (p)ppGpp synthetases regulate the pathogenesis of zoonotic Streptococcus suis.

    Science.gov (United States)

    Zhu, Jiawen; Zhang, Tengfei; Su, Zhipeng; Li, Lu; Wang, Dong; Xiao, Ran; Teng, Muye; Tan, Meifang; Zhou, Rui

    2016-10-01

    (p)ppGpp-mediated stringent response is one of the main adaption mechanism in bacteria, and the ability to adapt to environment is linked to the pathogenesis of bacterial pathogens. In the zoonotic pathogen Streptococcus suis, there are two (p)ppGpp synthetases, RelA and RelQ. To investigate the regulatory functions of (p)ppGpp/(p)ppGpp synthetases on the pathogenesis of S. suis, the phenotypes of the [(p)ppGpp(0)] mutant ΔrelAΔrelQ and its parental strain were compared. Light and electron microscopy observation showed that the mutant strain had a longer chain-length than its parental strain. Disruption of relA and relQ led to decreased adhesive and invasive ability to HEp-2 cells, and increased sensitivity to the blood killing and phagocytosis. Mouse infection experiments showed that the mutant strain was attenuated and easier to be cleaned up in vivo. Quantitative reverse transcription PCR (qRT-PCR) analysis indicated that the expressions of virulence related genes involving in morphology and virulence were down-regulated in the mutant strain. Our study demonstrated that the (p)ppGpp synthetases or (p)ppGpp can regulate the pathogenesis of this important zoonotic pathogen.

  16. Differential expression between "DSP-only" and DSP-PP523 transcripts in rat molar teeth.

    Science.gov (United States)

    Zhu, Ya-Qin; Song, Ryan M; Ritchie, Helena H

    2017-10-01

    To compare the expression patterns of two multiple transcripts derived from DSP-PP gene during tooth development. One is DSP-only transcript (i.e. does not encode PP) and the other is DSP-PP523 transcript, a main DSP-PP transcript. Unique antisense and sense riboprobes were generated from DSP-only and DSPPP523 cDNAs for in situ studies to examine DSP-only and DSP-PP523 transcript expression in developing molars. Paraffin-embedded sections (5-7μ m) from embryonic 20day, postnatal 2, 3 and 6days were deparaffined and hydrated. Tissues were prehybridized, then hybridized with DSP-only and DSP-PP523 anti-sense (AS) or sense (S) Digoxigenin labeled-riboprobes overnight, and washed. Anti-Digoxigenin antibodies conjugated to alkaline phosphatase were used to detect the presence of bound riboprobes by color reaction with NBT/BCIP. Stro-1 antibody was used for immunohistochemical analysis of Stro-1 protein expression in rat molars. We found that unlike the DSP-PP523 transcript, the DSP-only transcript does not express in the entire polarized mature odontoblasts but is expressed in the areas subjacent to the mature odontoblast layer. In addition, DSP-only transcript is expressed in the dental pulp. Interestingly, Stro-1 protein, a stem cell marker, was also identified in the areas subjacentto odontoblasts and in dental pulp. Differential expression of DSP-only and DSP-PP523 transcripts suggest that these two kinds of transcripts may play different roles during dentinogenesis. DSP-PP523 transcript is expressed in mature odontoblasts, which actively participates in dentin formation. DSP-only transcript might have a different function. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Signalling by the global regulatory molecule ppGpp in bacteria and chloroplasts of land plants.

    Science.gov (United States)

    Tozawa, Y; Nomura, Y

    2011-09-01

    The hyperphosphorylated guanine ribonucleotide ppGpp mediates the stringent response in bacteria. Biochemical and genetic studies of this response in Escherichia coli have shown that the biosynthesis of ppGpp is catalysed by two homologous enzymes, RelA and SpoT. RelA is activated in response to amino acid starvation, and SpoT responds to abiotic physical stress beside nutritional stress. All free-living bacteria, including Gram-positive firmicutes, contain RelA-SpoT homologues (RSH). Further, novel ppGpp biosynthetic enzymes, designated small alarmone synthetases (SASs), were recently identified in a subset of bacteria, including the Gram-positive organism Bacillus subtilis, and were shown to consist only of a ppGpp synthetase domain. Studies suggest that these SAS proteins contribute to ppGpp signalling in response to stressful conditions in a manner distinct from that of RelA-SpoT enzymes. SAS proteins currently appear to always occur in addition to RSH enzymes in various combinations but never alone. RSHs have also been identified in chloroplasts, organelles of photosynthetic eukaryotes that originated from endosymbiotic photosynthetic bacteria. These chloroplast RSHs are exclusively encoded in nuclear DNA and targeted into chloroplasts. The findings suggest that ppGpp may regulate chloroplast functions similar to those regulated in bacteria, including transcription and translation. In addition, a novel ppGpp synthetase that is regulated by Ca²⁺ as a result of the presence of two EF-hand motifs at its COOH terminus was recently identified in chloroplasts of land plants. This finding indicates the existence of a direct connection between eukaryotic Ca²⁺ signalling and prokaryotic ppGpp signalling in chloroplasts. The new observations with regard to ppGpp signalling in land plants suggest that such signalling contributes to the regulation of a wider range of cellular functions than previously anticipated.

  18. Properties of DOPO halogen-free flame retardant PP/EVA composite%DOPO无卤阻燃PP/EVA复合材料的性能研究

    Institute of Scientific and Technical Information of China (English)

    任庆龙; 夏英; 丛世杰; 张锋锋; 郭静; 张桂霞

    2016-01-01

    A flame-retardant polypropylene/ethylene vinyl acetate/9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (PP/EVA/DOPO) composite was prepared by mixing and hot pressing DOPO as halogen-free flame retardant and PP and EVA as resin matrix at the mass ratio of 4:1.The effects of the DOPO amount on the flame retardance , thermal property , mechanical proper-ties and processing properties of PP/EVA/DOPO composite were studied .The results showed that as compared with PP/EVA composite with no DOPO , the flame retardance of PP/EVA/DOPO composite was gradually increased , the bending strength was increased in some degree , but the tensile strength and impact strength were decreased as the DOPO amount was increased ; the limiting oxygen index of PP/EVA/DOPO composite was increased from 16.8% to 22.6% and the vertical flammability reached grade V-2, the temperature corresponding to the maximum thermogravimetric rate was increased by more than 20℃, and the melt flow index was increased to 7.795 g(10 min), and the processing flowability was profoundly improved as the mass fraction of DOPO was 10%.%采用9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物(DOPO)为无卤添加型阻燃剂,以聚丙烯(PP)、乙烯-醋酸乙烯酯(EVA)为基体树脂,按PP/EVA质量比4:1进行混炼、热压,制备了阻燃PP/EVA/DOPO复合材料,研究了DOPO用量对PP/EVA/DOPO阻燃性能、热性能、力学性能及加工性能的影响.结果表明:与未添加DOPO的PP/EVA相比,随着DOPO用量的增加,PP/EVA/DOPO的阻燃性能不断提高,热稳性有所提高,弯曲强度也有所提高,但拉伸强度和冲击强度有所下降;当DOPO质量分数为10%时,PP/EVA/DOPO极限氧指数由16.8%提高到22.6%,垂直燃烧性能达到V-2级别,最大热失重速率所对应的温度提高了20℃以上,熔体流动指数大幅提高达每10 min 7.795 g,加工流动性能明显改善.

  19. 增容剂对PP/回收PET共混物性能的影响%Effect of Compatibilizer on Properties of PP/Recycled PET Blends

    Institute of Scientific and Technical Information of China (English)

    周红军; 卢永乐; 何桂銮

    2012-01-01

    采用熔融共混的方法,制备了聚丙烯(PP)/回收聚对苯二甲酸乙二酯(r-PET)共混物,研究了增容剂甲基丙烯酸缩水甘油酯接枝聚丙烯(PP-g-GMA)对共混物力学性能、热稳定性的影响.结果表明:增容剂的加入能提高共混物的拉伸强度和拉伸模量;加入增容剂能显著提高共混物的热分解温度,增容剂使r-PET的熔点降低;增容剂对PP的结晶性能影响与熔融温度有关.%The polypropylene/recycled polyethylene terephthalate blends were prepared by melt method,and the effects of compatibilizer PP-g-GMA on mechanical properties and thermal properties were studied.The results show that: the tensile strength and modulus of PP/r-PET blends improve with the addition of compatibilizer; the decomposition temperature of the blends increases significantly,and the melt point decreases; the effect of compatibilizer on crystallization behavior of PP depends on the melting temperature of the blends.

  20. The Near-Threshold Production of Phi Mesons in pp Collisions

    CERN Document Server

    Hartmann, M; Keshelashvilli, I; Koch, H R; Mikirtytchiants, S; Barsov, S; Borgs, W; Büscher, M; Dymov, S; Hejny, V; Kleber, V; Koptev, V; Kulessa, P; Mersmann, T; Merzliakov, S; Mussgiller, A; Nekipelov, M; Nioradze, M; Ohm, H; Pysz, K; Schleichert, R; Stein, H J; Ströher, H; Watzlawik, K H; Wüstner, P

    2006-01-01

    The pp->pp phi reaction has been studied at the Cooler Synchrotron COSY-Juelich, using the internal beam and ANKE facility. Total cross sections have been determined at three excess energies epsilon near the production threshold. The differential cross section closest to threshold at epsilon=18.5 MeV exhibits a clear S-wave dominance as well as a noticeable effect due to the proton-proton final state interaction. Taken together with data for pp omega-production, a significant enhancement of the phi/omega ratio of a factor 8 is found compared to predictions based on the Okubo-Zweig-Iizuka rule.

  1. Theoretical study on pp --> p n pi+ reaction at medium energies

    CERN Document Server

    Ouyang, Z; Zou, B S; Xu, H S

    2009-01-01

    The $pp\\to p n \\pi^+$ reaction is a channel with the largest total cross section for pp collision in COSY/CSR energy region. In this work, we investigate individual contributions from various $N^*$ and $\\Delta^{*}$ resonances with mass up to about 2 GeV for the $pp\\to p n \\pi^+$ reaction. We extend a resonance model, which can reproduce the observed total cross section quite well, to give theoretical predictions of various differential cross sections for the present reaction at $T_p=2.88$ GeV. It could serve as a reference for identifying new physics in the future experiments at HIRFL-CSR.

  2. QCD with Jets and Heavy Flavour in pp and PbPb Collisions in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00377077; The ATLAS collaboration

    2016-01-01

    ATLAS has studied different aspects of QCD in pp and PbPb collisions. A summary of interesting recent results at centre-of-mass energies of 7 TeV, 8 TeV and 13 TeV (pp), and 2.76 TeV (PbPb) per nucleon pair is presented. Measurements using pp collisions of Z, W, photon, quarkonia and open charm production differential cross sections in a variety of variables are presented. Jet and heavy flavour muon measurements in PbPb collisions, aimed to test the properties of the Quark Gluon Plasma with the view of better understanding of jet quenching, are also presented.

  3. Catalytic activity of a novel serine/threonine protein phosphatase PP5 from Leishmania major

    Directory of Open Access Journals (Sweden)

    Norris-Mullins Brianna

    2014-01-01

    Full Text Available Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. Our knowledge of protein phosphatases (PPs and their implication in signaling events is very limited. Here we report the expression, characterization and mutagenesis analysis of a novel protein phosphatase 5 (PP5 in Leishmania major. Recombinant PP5 is a bona fide phosphatase and is enzymatically active. Site-directed mutagenesis revealed auto-inhibitory roles of the N-terminal region. This is a rational first approach to understand the role of PP5 in the biology of the parasite better as well as its potential future applicability to anti-parasitic intervention.

  4. PP: A graphics post-processor for the EQ6 reaction path code

    Energy Technology Data Exchange (ETDEWEB)

    Stockman, H.W.

    1994-09-01

    The PP code is a graphics post-processor and plotting program for EQ6, a popular reaction-path code. PP runs on personal computers, allocates memory dynamically, and can handle very large reaction path runs. Plots of simple variable groups, such as fluid and solid phase composition, can be obtained with as few as two keystrokes. Navigation through the list of reaction path variables is simple and efficient. Graphics files can be exported for inclusion in word processing documents and spreadsheets, and experimental data may be imported and superposed on the reaction path runs. The EQ6 thermodynamic database can be searched from within PP, to simplify interpretation of complex plots.

  5. The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation.

    Science.gov (United States)

    Ross, Wilma; Vrentas, Catherine E; Sanchez-Vazquez, Patricia; Gaal, Tamas; Gourse, Richard L

    2013-05-01

    The global regulatory nucleotide ppGpp ("magic spot") regulates transcription from a large subset of Escherichia coli promoters, illustrating how small molecules can control gene expression promoter-specifically by interacting with RNA polymerase (RNAP) without binding to DNA. However, ppGpp's target site on RNAP, and therefore its mechanism of action, has remained unclear. We report here a binding site for ppGpp on E. coli RNAP, identified by crosslinking, protease mapping, and analysis of mutant RNAPs that fail to respond to ppGpp. A strain with a mutant ppGpp binding site displays properties characteristic of cells defective for ppGpp synthesis. The binding site is at an interface of two RNAP subunits, ω and β', and its position suggests an allosteric mechanism of action involving restriction of motion between two mobile RNAP modules. Identification of the binding site allows prediction of bacterial species in which ppGpp exerts its effects by targeting RNAP.

  6. Evaluation of the degree of dispersion of organoclay on nanocomposites with PP/EPDM; Avaliacao do grau de dispersao de argilas organofilicas em nanocompositos de PP/EPDM

    Energy Technology Data Exchange (ETDEWEB)

    Braga, F.C.F.; Oliveira, M.G., E-mail: fernanda.braga@int.gov.b [Instituto Nacional de Tecnologia (DPCM/INT), Rio de Janeiro, RJ (Brazil). Div. de Processamento e Caracterizacao de Materiais; Furtado, C.R.G. [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil)

    2010-07-01

    Nanocomposites of thermoplastic elastomer (TPE) composed by PP/EPDM 1/1 blend and organoclay were obtained by the melt intercalation in an internal chamber mix. Initially, a masterbatch of maleinized polypropylene (PP-MA) and clay modified with alkyl ammonium salt in the ratio 3:1 was prepared, and then, added to TPE matrix to obtain loads of 2,5; 5 and 7 wt% of clay in the nanocomposite. The dispersion degree of clay in TPE matrix was evaluated by X-ray diffraction and parallel plate rheometry. The intercalation/exfoliate degree or the degree of dispersion varied with clay content, as observed by X-ray diffraction. This behavior was confirmed by the profile of the curves of elastic modulus versus frequency, which presented different slopes in the region of low frequency, due to the presence of clay and PP-MA. (author)

  7. Effects of PP333 on Growth and Physiology of Carnation%PP333对香石竹生长及生理的影响

    Institute of Scientific and Technical Information of China (English)

    马智宏; 贾瑞智; 关军锋

    2000-01-01

    以香石竹幼苗为试材,进行叶面喷施PP333试验,结果表明,与对照相比叶面喷施PP333使植株生长速率下降,叶片过氧化物酶活性显著提高,在香石竹幼苗生长后期植株体的叶绿素、可溶性蛋白质含量及超氧物歧化酶活性升高。%The carnation seedlings were used in this experiment. The determinafion results showed that in contrast to control, the fo liar spraying PP333 decreased growth rate, increased significantly peroxidase activity of leaves at all stage, and increased content of chlorophyll and protein, as well as the activity of superoxide dismatuse in carnation leaves only at late growth stage.

  8. Preparation and Property analysis of PP/POE blends%PP/POE共混物的制备及其性能分析

    Institute of Scientific and Technical Information of China (English)

    陈全虎

    2015-01-01

    通过实验筛选聚丙烯基础树脂及其配方,研究了聚烯烃弹性体(POE)用量和加工工艺对聚丙烯共混物性能的影响。结果表明,随着POE用量的增加,聚丙烯共混物的抗冲击性能显著提高。%Base resin and its ratio in PP/POE blends was selected in this test, and the influence of POE amount and processing condition on PP/POE blends was studied. The results showed that the impact property of PP/POE blends was improved significantly with the addition of thermoplastic elastomer gradually.

  9. The enhancement effect of pp38 gene product on the activity of its upstream bi-directional promoter in Marek's disease virus

    Institute of Scientific and Technical Information of China (English)

    DING; Jiabo; CUI; Zhizhong; JIANG; Shijin; REDDY; Sanjay

    2006-01-01

    There was a bi-directional promoter between gene 38 kd phosphorylated protein (pp38) gene and 1.8-kb mRNA transcript gene family in the genome of Marek's disease virus (MDV). In this study, enhanced green fluorescence protein (EGFP) reporter plamids, pP(pp38)-EGFP and pP(1.8- kb)-EGFP, were constructed under this bi-directional promoter in two directions. The two plasmids were transfected into uninfected chicken embryo fibroblast (CEF), MDV clone rMd5 infected CEF (rMd5-CEF) and pp38-deleted derivative rMd5Δpp38 infected CEF (rMd5Δpp38-CEF) respectively. Transfection analysis showed that EGFP was only expressed in rMd5-CEF, and no EGFP could be detected in uninfected CEF or rMd5Δpp38-CEF, implying that pp38 was a factor influencing the activity of the promoter. The pp38-expressing recombinant plasmid pcDNA-pp38 was constructed to co- transfect CEF or rMd5Δpp38-CEF with pP(pp38)-EGFP or pP(1.8-kb)-EGFP. In this case, EGFP could be detected only in rMd5Δpp38-CEF but still not in uninfected CEF, implying that pp38 needs other protein(s) to work together for the complete trans-acting activity. Another MDV gene, 24 kd phosphorylated protein pp24 gene was cloned into pcDNA3.1 as a pp24-expressing recombinant plasmid pcDNA-pp24. When uninfected CEF was co-transfected with pcDNA-pp38, pcDNA-pp24 and EGFP expressing plasmids pP(pp38)-EGFP or pP(1.8-kb)-EGFP, the EGFP could be detected. These results indicated that pp38 and pp24 could enhance the activity of the promoter when they worked together. DNA mobility shift assay showed that pp38 would bind to the bi-directional promoter with the co-existing of pp24, although neither of them alone influenced mobility of the promoter DNA. All the above suggested that MDV pp38 could transactivate the bi-directional promoter when combined with pp24. The results also indicated that the activity of the promoter in the direction of 1.8-kb mRNA was significantly stronger than that of pp38 direction.

  10. Neuropeptides Y, YY, PP and their clinical significance

    Directory of Open Access Journals (Sweden)

    Mariola Śliwińska-Mossoń

    2013-07-01

    Full Text Available peripheral nervous system. Considering the structure and evolutionary origin, neuropeptideY (NPY is a peptide of the same family as peptide YY (PYY and pancreatic polypeptide(PP. These proteins were discovered relatively recently, however, knowledge about them isdeepened. They are 36-amino acid peptide acting through G-protein coupled receptors, Y1,Y2, Y3, Y4, Y5 and Y6. The diverse structure C-terminus of the peptide and protein binding toreceptors affect the biological activity and the physiological effects on the digestive system,blood vessels, and the center of hunger and satiety in the hypothalamus. Peptides have anorexicproperties, they regulate appetite and food intake mainly through the intestinal cerebrospinalaxis and the hypothalamus. These substances represent an important potential target of newdrugs in the long-term treatment and prevention of obesity. Furthermore, neuropeptide Yaffects many processes depending on the central nervous system modifies ethanol consumption,affect circadian rhythms, memory processes, anxiety behavior. Peripherally NPY affectssmooth muscle contraction of the blood vessels, blood pressure, and atherogenic processes.Conducted more thorough research trying to define the role and participation of variousneuropeptides in the development of diseases of the pancreas and the gastrointestinal tract,cardiovascular system and use it for diagnosis.

  11. pp Elastic Scattering at LHC in Near Forward Direction

    CERN Document Server

    Islam, M M; Prokudin, A V

    2004-01-01

    We predict pp elastic differential cross section at LHC at the c.m. energy sqrt(s) = 14 TeV and momentum transfer range |t| = 0 - 10 GeV^2, which is planned to be measured by the TOTEM group. The field theory model underlying our phenomenological investigation describes the nucleon as a composite object with an outer cloud of quark-antiquark condensate, an inner core of topological baryonic charge, and a still smaller quark-bag of valence quarks. The model satisfactorily describes the asymptotic behavior of total cross section as a function of s and the real to imaginary ratio of the forward scattering amplitude as a function of s. It also describes well the the measured antiproton-proton elastic differential cross sections at sqrt(s)= 546 GeV, 630 GeV, and 1.8 TeV. The large |t| elastic amplitude of the model incorporates the BFKL Pomeron in next to leading order approximation, the perturbative dimensional counting behavior, and the confinement of valence quarks in a small region within the nucleon.

  12. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Yi; Zhou, Yajuan [Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan 430071 (China); Cheng, Long [Department of Interventional Radiology, the Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215001 (China); Hu, Desheng; Zhou, Xiaoyi; Wang, Zhaohua [Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan 430071 (China); Xie, Conghua, E-mail: chxie_65@hotmail.com [Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China); Zhou, Fuxiang, E-mail: ZhouFuxiangwuhan@126.com [Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan 430071 (China)

    2015-09-11

    Here we explored the potential effect of PP121, a novel dual inhibitor of tyrosine and phosphoinositide kinases, against human esophageal cancer cells. We showed that PP121 exerted potent cytotoxic effect in primary (patient-derived) and established (Eca-109, TE-1 and TE-3 lines) esophageal cancer cells, possibly through activating caspase-3-dependnent apoptosis. PP121 was, however, non-cytotoxic to the normal human esophageal epithelial cells (EECs). At the molecular level, we showed that PP121 blocked Akt-mTOR (mammalian target of rapamycin) activation in esophageal cancer cells, which was restored by introducing a constitutively-active Akt (CA-Akt). Yet, CA-Akt only partly inhibited cytotoxicity by PP121 in Eca-109 cells. Importantly, we showed that PP121 inhibited nuclear factor kappa B (NFκB) signaling activation in esophageal cancer cells, which appeared independent of Akt-mTOR blockage. In vivo, oral administration of PP121 remarkably inhibited Eca-109 xenograft growth in nude mice, and significantly improved mice survival. Further, the immunohistochemistry (IHC) and Western blot assays analyzing xenografted tumors showed that PP121 inhibited Akt-mTOR and NFκB activations in vivo. Together, we demonstrate that PP121 potently inhibits esophageal cancer cells in vitro and in vivo, possibly through concurrently inhibiting Akt-mTOR and NFκB signalings. - Highlights: • PP121 is cytotoxic against primary and established esophageal cancer cells. • PP121 induces caspase-3-dependnent apoptosis in esophageal cancer cells. • PP121 blocks Akt-mTOR activation in esophageal cancer cells. • PP121 inhibits NFκB activation, independent of Akt-mTOR blockage. • PP121 inhibits Eca-109 xenograft growth and Akt-mTOR/NFκB activation in vivo.

  13. Study on Properties of PP/Nano-CaCO3/EPDM Composite%PP/Nano-CaCO3/EPDM复合材料性能研究

    Institute of Scientific and Technical Information of China (English)

    崔文广; 高岩磊; 刘会茹; 郧海丽

    2013-01-01

    PP/nano-CaCO3/EPDM composite was prepared by melt blending. The effect of the nano-CaCO3 amount and EPDM amount on mechanical property of the PP/nano-CaCO3/EPDM composite were respectively studied. The results showed that the impact strength and tensile strength of the PP/ nano-CaCO3/EPDM composite both increased with the nano-CaCO3 content, and then decreased with the nano-CaCO3 content, and the flexural modulus of the composite increased with the nano-CaCO3 content. The impact strength of the PP/nano-CaCO3/EPDM composite increased with the EPDM content, and the tensile strength and flexural modulus of the PP/nano-CaCO3/EPDM composite both decreased with the EPDM content.%采用熔融共混法制备出了聚丙烯(PP)/纳米碳酸钙(nano-CaCO3)/三元乙丙橡胶(EPDM)复合材料.分别研究了nano-CaCO3和EPDM的加入量对复合材料力学性能的影响.结果表明:随着nano-CaCO3用量的增加,复合材料的冲击强度和拉伸强度均呈现出先增加后降低的趋势,弯曲模量呈增加趋势;随着EPDM用量的增加,复合材料的冲击强度呈增加趋势,拉伸强度和弯曲模量均呈下降趋势.

  14. Eccentricity fluctuations make flow measurable in high multiplicity p-p collisions

    CERN Document Server

    Casalderrey-Solana, Jorge

    2010-01-01

    Elliptic flow is a hallmark of collectivity in hadronic collisions. Its measurement relies on analysis techniques which require high event multiplicity and could be applied so far to heavy ion collisions only. Here, we delineate the conditions under which elliptic flow becomes measurable in the samples of high-multiplicity ($dN_{\\rm ch}/dy \\geq 50$) p-p collisions, which will soon be collected at the LHC. We observe that fluctuations in the p-p interaction region can result in a sizable spatial eccentricity even for the most central p-p collisions. Under relatively mild assumptions on the nature of such fluctuations and on the eccentricity scaling of elliptic flow, we find that the resulting elliptic flow signal in high-multiplicity p-p collisions at the LHC becomes measurable with standard techniques.

  15. Spatial Memory Deficit and Tau Hyperphosphorylation Induced by Inhibiting PP2A in Rat Brain

    Institute of Scientific and Technical Information of China (English)

    TIAN Qing; ZHENG Hong-yun; CHEN Juan; LI Hong-lian; GONG Cheng-xin; WANG Jian-zhi

    2005-01-01

    Hyperphosphorylation of Tau in Alzheimer's disease (AD) brain appears to be caused by a down-regulation of protein phosphatase 2A (PP2A). In this study, we selectively inhibited PP2A by injection of okadaic acid (OA) into the Meynert nucleus basalis of rats and found that 0.4 pmol of OA injection induced approximately 60% inhibition of PP2A 24 h after injection, 13% inhibition 48 h after injection and no obvious inhibition 72 h after injection. Hyperphosphorylation of Tau at Ser-198/Ser-199/Ser-202 and Ser-396/Ser-404 and spatial memory deficit of rats were induced 24 h after 0.4 pmol of OA injection. This study suggests that a down-regulation of PP2A may underlie abnormal hyperphosphorylation of cytoskeletal proteins leading to neurofibrillary degeneration in AD.

  16. pp-GalNAc-T4表达载体的构建

    Institute of Scientific and Technical Information of China (English)

    李喆; 郭向红; 吴士良

    2011-01-01

    目的 构建pp - GalNAc - T4的正义表达载体.方法 采用质粒转染法构建真核表达载体.结果 构建了pp -GalNAc-T4的正义表达载体,并得到了鉴定.结论 构建了pp - GalNAc - T4的正义表达载体,研究发现了在pp - GalNAc - T4c DNA转染NB4细胞株后,在mRNA水平及蛋白水平能稳定上调pp-GalNAc-T4的表达,可以用于以后的研究.

  17. Study of the pp-> np+ reaction at 1.25 GeV with HADES

    CERN Document Server

    Liu, T; Agakishiev, G; Agodi, C; Balanda, A; Bellia, G; Belver, D; Belyaev, A; Blanco, A; Böhmer, M; Boyard, J L; Braun-Munzinger, P; Cabanelas, P; Castro, E; Christ, T; Destefanis, M; Díaz, J; Dohrmann, F; Dybczak, A; Fabbietti, L; Fateev, O; Finocchiaro, P; Fonte, P; Friese, J; Fröhlich, I; Galatyuk, T; Garzón, J A; Gernhäuser, R; Gil, A; Gilardi, C; Golubeva, M; González-Díaz, D; Grosse, E; Guber, F; Heilmann, M; Hennino, T; Holzmann, R; Ierusalimov, A; Iori, I; Ivashkin, A; Jurkovic, M; Kämpfer, B; Kanaki, K; Karavicheva, T; Kirschner, D; Koenig, I; Koenig, W; Kolb, B W; Kotte, R; Kozuch, A; Krása, A; Krížek, F; Krücken, R; Kühn, W; Kugler, A; Kurepin, A; Lamas-Valverde, J; Lang, S; Lange, J S; Lapidus, K; Lopes, L; Lorenz, M; Maier, L; Mangiarotti, A; Marín, J; Markert, J; Metag, V; Michalska, B; Michel, J; Mishra, D; Moriničre, E; Mousa, J; Müntz, C; Naumann, L; Novotny, R; Otwinowski, J; Pachmayer, Y C; Palka, M; Parpottas, Y; Pechenov, V; Pechenova, O; Pérez Cavalcanti, T; Pietraszko, J; Przygoda, W; Ramstein, B; Reshetin, A; Rustamov, A; Sadovsky, A; Salabura, P; Schmah, A; Simon, R; Sobolev, Yu G; Spataro, S; Spruck, B; Ströbele, H; Stroth, J; Sturm, C; Sudol, M; Tarantola, A; Teilab, K; Tlustý, P; Traxler, M; Trebacz, R; Tsertos, H; Veretenkin, I; Wagner, V; Weber, M; Wisniowski, M; Wüstenfeld, J; Yurevich, S; Zanevsky, Y V; Zhou, P; Zumbruch, P

    2010-01-01

    In pp collisions at 1.25 GeV kinetic energy, the HADES collaboration aimed at investigating the di-electron production related to (1232) Dalitz decay ( + ! pe+e−). In order to constrain the models predicting the cross section and the production mechanisms of resonance, the hadronic channels have been measured and studied in parallel to the leptonic channels. The analyses of pp ! np + and pp ! pp 0 channels and the comparison to simulations are presented in this contribution, in particular the angular distributions being sensitive to production and decay. The accurate acceptance corrections have been performed as well, which could be tested in all the phase space region thanks to the high statistic data. These analyses result in an overall agreement with the one- exchange model and previous data.

  18. ppGpp and polyphosphate modulate cell cycle progression in Caulobacter crescentus.

    Science.gov (United States)

    Boutte, Cara C; Henry, Jonathan T; Crosson, Sean

    2012-01-01

    Caulobacter crescentus differentiates from a motile, foraging swarmer cell into a sessile, replication-competent stalked cell during its cell cycle. This developmental transition is inhibited by nutrient deprivation to favor the motile swarmer state. We identify two cell cycle regulatory signals, ppGpp and polyphosphate (polyP), that inhibit the swarmer-to-stalked transition in both complex and glucose-exhausted media, thereby increasing the proportion of swarmer cells in mixed culture. Upon depletion of available carbon, swarmer cells lacking the ability to synthesize ppGpp or polyP improperly initiate chromosome replication, proteolyze the replication inhibitor CtrA, localize the cell fate determinant DivJ, and develop polar stalks. Furthermore, we show that swarmer cells produce more ppGpp than stalked cells upon starvation. These results provide evidence that ppGpp and polyP are cell-type-specific developmental regulators.

  19. K-K-pp - an important gateway toward multi-kaonic nuclei

    CERN Document Server

    Maeda, Shuji; Yamazaki, Toshimitsu

    2016-01-01

    Based on our Faddeev-Yakubowsky calculations of four-body kaonic nuclear systems it was revealed that the structure of K-K-pp is well approximated by two Lambda*=K-p's with strong mutual attraction. It is vitally important to study this nucleus, as it is an essential gateway toward multi-Lambda* nuclei. Two experimental proposals are presented: i) production of K-K-pp by p+p reactions at T_p = 7 GeV, and ii) search for K-K-pp from the invariant mass of M(Lambda-Lambda) around 2.6 GeV/c2 in high-energy HI reactions.

  20. CP violation in $B \\to PP$ in the SM with SU(3) symmetry

    CERN Document Server

    Fu, H K; Hsiao, Y K; Shi, J Q; Fu, Han-Kuei; He, Xiao-Gang; Hsiao, Yu-Kuo; Shi, Jian-Qing

    2003-01-01

    In this paper we study CP violation in $B\\to PP$ decays in the Standard Model using SU(3) flavor symmetry. With SU(3) symmetry only seven hadronic parameters are needed to describe $B\\to PP$ decays in the SM when annihilation contributions are neglected. The relevant hadronic parameters can be determined using known experimental data from $B\\to \\pi\\pi$ and $B\\to K \\pi$. We predict branching ratios and CP asymmetries for some of the unmeasured $B \\to PP$ decays. Some of the CP asymmetries can be large and measured at B factories. The effects of annihilation contributions can also be studied using present experimental data. Inclusion of annihilation contributions introduces six more hadronic parameters. We find that annihilation contributions are in general small, but can have significant effects on CP asymmetries and some $B_s \\to PP$.

  1. ALICE at LHC: first data from p+p and perspectives for A+A

    NARCIS (Netherlands)

    Peitzmann, T.

    2010-01-01

    Outline: Hot and dense QCD matter: Examples of previous data and theoretical understanding; Perspectives for heavy-ion collisions at LHC. The ALICE experiment: Experimental setup, commissioning, calibration; Detector performance. First results from p+p collisions: Multiplicity measurements; I

  2. Facile Method to Fabricate Highly Thermally Conductive Graphite/PP Composite with Network Structures.

    Science.gov (United States)

    Feng, Changping; Ni, Haiying; Chen, Jun; Yang, Wei

    2016-08-03

    Thermally conductive polymer composites have aroused significant academic and industrial interest for several decades. Herein, we report a novel fabrication method of graphite/polypropylene (PP) composites with high thermal conductivity in which graphite flakes construct a continuous thermally conductive network. The thermal conductivity coefficient of the graphite/PP composites is markedly improved to be 5.4 W/mK at a graphite loading of 21.2 vol %. Such a great improvement of the thermal conductivity is ascribed to the occurrence of orientations of crystalline graphite flakes with large particles around PP resin particles and the formation of a perfect thermally conductive network. The model of Hashin-Shtrikman (HS) is adopted to interpret the outstanding thermally conductive property of the graphite/PP composites. This work provides a guideline for the easy fabrication of thermally conductive composites with network structures.

  3. Novel approach to synthesizing poly(propylene)-graft-poly(styrene) (PP-g-PS)

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    A novel synthetic route used for preparing PP-g-PS was designed. With this synthetic route, a series of graft copolymers with different contents of PS chain were synthesized successfully, and characterized by 13C-NMR, DSC, GPC.

  4. Intrinsic Fluctuations of the Proton Saturation Momentum Scale in High Multiplicity p+p Collisions

    CERN Document Server

    McLerran, Larry

    2016-01-01

    High multiplicity events in p+p collisions are studied using the theory of the Color Glass Condensate. We show that intrinsic fluctuations of the proton saturation momentum scale are needed in addition to the sub-nucleonic color charge fluctuations to explain the very high multiplicity tail of distributions in p+p collisions. The origin of such intrinsic fluctuations are presumably non-perturbative in nature. Classical Yang Mills simulations using the IP-Glasma model are performed to make quantitative estimations. We find that fluctuations as large as $\\cal O$(1) of the average values of the saturation momentum scale can lead to rare high multiplicity events seen in p+p data at RHIC and LHC energies. Using the available data on multiplicity distributions we try to constrain the distribution of the proton saturation momentum scale and make predictions for the multiplicity distribution in 13 TeV p+p collisions.

  5. Heavy-flavor correlations and multiplicity dependence in pp and p--Pb collisions with ALICE

    CERN Document Server

    INSPIRE-00246108

    2016-01-01

    The production of heavy quarks in pp collisions at the LHC energies provides a reliable test of perturbative QCD calculations. Comparisons of pp and $\\pPb$ measurements of their hadronization products allow us to investigate how cold nuclear matter effects affect the heavy-quark production. We present ALICE measurements of azimuthal correlations of prompt D mesons with charged hadrons in pp collisions at $\\s$ = 7 TeV and $\\pPb$ collisions at $\\sNN$ = 5.02 TeV. We also show the per-event D-meson yields as a function of the charged-particle multiplicity in pp collisions at $\\s$ = 7 TeV.

  6. Spectroscopic observation of SN 2017pp by NUTS (NOT Un-biased Transient Survey)

    Science.gov (United States)

    Pastorello, A.; Elias-Rosa, N.; Benetti, S.; Cappellaro, E.; Terreran, G.; Tomasella, L.; Tronsgaard, R.

    2017-01-01

    The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of SN 2017pp in PGC 1378162. The candidate was discovered by F. Ciabattari, E. Mazzoni, S. Donati (ISSP; http://italiansupernovae.org).

  7. Velocity-independent layer stripping of PP and PS reflection traveltimes

    Digital Repository Service at National Institute of Oceanography (India)

    Dewangan, P.; Tsvankin, I.

    Building accurate interval velocity models is critically important for seismic imaging and AVO (amplitude variation with offset) analysis. Here, we adapt the PP + PS = SS method to develop an exact technique for constructing the interval traveltime...

  8. Bacterial global regulators DksA/ppGpp increase fidelity of transcription.

    Science.gov (United States)

    Roghanian, Mohammad; Zenkin, Nikolay; Yuzenkova, Yulia

    2015-02-18

    Collisions between paused transcription elongation complexes and replication forks inevitably happen, which may lead to collapse of replication fork and could be detrimental to cells. Bacterial transcription factor DksA and its cofactor alarmone ppGpp were proposed to contribute to prevention of such collisions, although the mechanism of this activity remains elusive. Here we show that DksA/ppGpp do not destabilise transcription elongation complexes or inhibit their backtracking, as was proposed earlier. Instead, we show, both in vitro and in vivo, that DksA/ppGpp increase fidelity of transcription elongation by slowing down misincorporation events. As misincorporation events cause temporary pauses, contribution to fidelity suggests the mechanism by which DksA/ppGpp contribute to prevention of collisions of transcription elongation complexes with replication forks. DksA is only the second known accessory factor, after transcription factor Gre, that increases fidelity of RNA synthesis in bacteria.

  9. Expression and mechanism of regulation of PP2A/Pr65 in ameloblastoma.

    Science.gov (United States)

    Gao, Xiuqiu; Wang, Guannan; Zhang, Yun-Kai; Zhong, Ming

    2014-06-01

    This study aimed to investigate the expression of PP2A/PR65 protein in ameloblastoma and the molecular mechanisms underlying the regulation of PP2A/PR65. The association between PP2A/PR65 and the clinicopathological characteristics of tumor specimens in ameloblastoma were to provide a theoretical basis for the diagnosis, therapy and prognosis of ameloblastoma. Streptavidin-peroxidase (S-P) immunohistochemical staining was used to detect PP2A/Pr65 expression changes in a total of 68 cases of ameloblastoma, six ameloblastic carcinomas, 21 squamous cell carcinomas and seven normal oral mucosas. Western blot was used to analyze PP2A/PR65 protein expression in 15 cases of ameloblastoma and three cases of normal oral mucosa. Of the 68 cases analyzed, four cases were negative, 25 cases were weakly positive, 20 cases were moderately positive and 19 cases were strongly positive. In six cases of ameloblastic carcinoma, three cases were weak positive, one case was positive, two cases were strongly positive and none were negative. In 21 cases of squamous cell carcinomas, three cases were negative, 17 cases were weakly positive, one case was moderately positive and none were strongly positive. Western blot analysis showed that, PP2A/Pr65 protein expression was lower in ameloblastoma tissue compared with normal oral mucosa. Reduced expression of PP2A/PR65 in ameloblastoma compared with normal oral mucosa indicates that PP2A/PR65 is involved in the occurrence and development of ameloblastoma. Copyright © 2013 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

  10. Effects of (p)ppGpp on the progression of the cell cycle of Caulobacter crescentus.

    Science.gov (United States)

    Gonzalez, Diego; Collier, Justine

    2014-07-01

    Bacteria must control the progression of their cell cycle in response to nutrient availability. This regulation can be mediated by guanosine tetra- or pentaphosphate [(p)ppGpp], which are synthesized by enzymes of the RelA/SpoT homologue (Rsh) family, particularly under starvation conditions. Here, we study the effects of (p)ppGpp on the cell cycle of Caulobacter crescentus, an oligotrophic bacterium with a dimorphic life cycle. C. crescentus divides asymmetrically, producing a motile swarmer cell that cannot replicate its chromosome and a sessile stalked cell that is replication competent. The swarmer cell rapidly differentiates into a stalked cell in appropriate conditions. An artificial increase in the levels of (p)ppGpp in nonstarved C. crescentus cells was achieved by expressing a truncated relA gene from Escherichia coli, encoding a constitutively active (p)ppGpp synthetase. By combining single-cell microscopy, flow cytometry approaches, and swarming assays, we show that an increase in the intracellular concentration of (p)ppGpp is sufficient to slow down the swarmer-to-stalked cell differentiation process and to delay the initiation of chromosome replication. We also present evidence that the intracellular levels of two master regulators of the cell cycle of C. crescentus, DnaA and CtrA, are modulated in response to (p)ppGpp accumulation, even in the absence of actual starvation. CtrA proteolysis and DnaA synthesis seem indirectly inhibited by (p)ppGpp accumulation. By extending the life span of the motile nonreproductive swarmer cell and thus promoting dispersal and foraging functions over multiplication under starvation conditions, (p)ppGpp may play a central role in the ecological adaptation of C. crescentus to nutritional stresses.

  11. Integral and derivative dispersion relations for pp and $\\overline{p}p$ amplitudes

    CERN Document Server

    Alkin, A

    2010-01-01

    The methods of integral dispersion relations (IDR) and derivative dispersion relations (DDR) are applied for analysis of the data on pp and ¯pp total cross sections and ratios of real to imaginary part of elastic forward scattering amplitude. The models of pomeron behaving as triple, double and simple pole (with intercept larger than one) in the angular momentum plane are considered. Predictions of the models are given for the TOTEM measurements at 7 and 14 TeV.

  12. Placental Protein 13 (PP13 – a placental immunoregulatory galectin protecting pregnancy

    Directory of Open Access Journals (Sweden)

    Nandor Gabor Than

    2014-08-01

    Full Text Available Galectins are glycan-binding proteins that regulate innate and adaptive immune responses, and some confer maternal-fetal immune tolerance in eutherian mammals. A chromosome 19 cluster of galectins has emerged in anthropoid primates, species with deep placentation and long gestation. Three of the five human cluster galectins are solely expressed in the placenta, where they may confer additional immunoregulatory functions to enable deep placentation. One of these is galectin-13, also known as Placental Protein 13 (PP13. It has a jelly-roll fold, carbohydrate-recognition domain and sugar-binding preference resembling to other mammalian galectins. PP13 is predominantly expressed by the syncytiotrophoblast and released from the placenta into the maternal circulation. Its ability to induce apoptosis of activated T cells in vitro, and to divert and kill T cells as well as macrophages in the maternal decidua in situ suggests important immune functions. Indeed, mutations in the promoter and an exon of LGALS13 presumably leading to altered or non-functional protein expression are associated with a higher frequency of preeclampsia and other obstetrical syndromes, which involve immune dysregulation. Moreover, decreased placental expression of PP13 and its low first trimester maternal serum concentrations are associated with elevated risk of preeclampsia. Indeed, PP13 turned to be a good early biomarker to assess maternal risk for the subsequent development of pregnancy complications caused by impaired placentation. Due to the ischemic placental stress in preterm preeclampsia, there is an increased trophoblastic shedding of PP13 immunopositive microvesicles starting in the second trimester, which leads to high maternal blood PP13 concentrations. Our meta-analysis suggests that this phenomenon may enable the potential use of PP13 in directing patient management near to or at the time of delivery. Recent findings on the beneficial effects of PP13 on decreasing

  13. S-wave $\\pi^0$ Production in pp Collision in a Covariant OBE Model

    CERN Document Server

    Gedalin, E; Razdolskaya, L A

    1999-01-01

    The total cross section for the pp to pp $\\pi^0$ reaction at energies close to threshold is calculated in a covariant one-boson-exchange model. The amplitudes for the elementary BN to N$\\pi^0$ processes are taken to be the sum of s, u and t pole terms. The main contributions to the primary productionamplitude is due to a sigma meson exchange. Both the scale and energy dependence of the cross section are perfectly reproduced.

  14. Evaluation of ALA-induced PpIX as a photosensitizer for PDT in cats

    Science.gov (United States)

    Lucroy, Michael D.; Edwards, Benjamin F.; Peavy, George M.; Krasieva, Tatiana B.; Griffey, Stephen M.; Madewell, Bruce R.

    1998-07-01

    Given exogenously, ALA defeats intrinsic regulatory feedback mechanisms allowing intracellular accumulation of protoporphyrin IX (PpIX), a highly efficient photosensitizer. In vivo, PpIX synthesis in neoplastic mammary tissues averages 20-fold higher than in normal mammary tissues. PpIX is retained intracellularly, unlike perivascular localization of other photosensitizers, and it is then cleared quickly from the body. In vitro, ALA induced PpIX production in our laboratory in 6 cell lines tested, including an established feline kidney cell line and dermal fibroblasts from primary skin biopsy explant, resulting in photosensitization. Fluorescent microscopy confirmed PpIX production in skin adnexae following ALA administration in a normal cat. To evaluate toxicity, three cats were treated with a single i.v. dose of ALA (either 100, 200, of 400 mg/kg) and followed for 7 days. Cats receiving 100 or 200 mg/kg ALA i.v. had elevated liver enzymes and bilirubin within 24 hours. Histopathology revealed hydropic changes in the liver and renal fibrosis. The cat receiving 400 mg/kg ALA intravenously had cutaneous flush, bradycardia and apnea associated with ALA administration; within 24 hours the cat was lethargic, anorectic and icteric. ALT, AST and bilirubin concentrations had increased significantly. At necropsy the liver had a prominent lobular pattern; histopathology revealed severe periportal hepatitis and splenic necrosis. Systemically administered ALA induces PpIX production, but toxicity may preclude its clinical application in the cat. PpIX levels seem to be more time dependent than those dependent at these three ALA doses and they are well beyond the saturation point for adequate PpIX conversion. The literature is scant regarding toxicity associated with parenteral administration of ALA.

  15. STUDY ON THE MISCIBILITY OF DYNAMICALLY VULCANIZED EPDM/PP BLEND BY POSITRON ANNIHILATION SPECTROSCOPY

    Institute of Scientific and Technical Information of China (English)

    Tao Jiang; Xue-liang Jiang; Shi-yuan Cheng; Yi-qun Dai; Shao-jie Wang; Bo Wang

    2000-01-01

    Positron annihilation spectroscopy (PAS) was utilized to investigate the relationship between the free-volume hole properties and miscibility of dynamically vulcanized EPDM/PP blend. The results showed that the noncrystalline region of PP and EPDM in the blend was partially miscible and the miscibility of the blend became worse when the weight percent of EPDM was <50%. This was also demonstrated by DMTA and mechanical properties of the blends with various compositions.

  16. RESULTS FROM PP AT 62.4 AND 200 GeV WITH THE BRAHMS EXPERIMENTATION.

    Energy Technology Data Exchange (ETDEWEB)

    VIDEBAEK,F.; (BRAHMS EXPERIMENTATION)

    2007-02-11

    Measurements of elementary pp collisions are essential for understanding heavy ion collisions. R.esu1ts for pp collisions at 200 and 62.4 GeV are presented. At both energies NLO pQCD describes pion production well. The measured pion transverse single spin asymmetries are very large at 62.4 GeV and are reasonably well described by models relying on pQCD at transverse momenta larger than 1 GeV/c.

  17. t dependence of the slope of the high energy elastic pp cross section

    CERN Document Server

    Khoze, V A; Ryskin, M G

    2014-01-01

    We consider the main factors which cause the variation of the value of the local slope of the elastic pp cross section B(t)=d[\\ln(d\\sigma_el(pp)/dt]/dt with t. Namely, we discuss the role of the pion-loop insertion in the pomeron trajectory, the t-dependence of the pomeron-nucleon coupling and the role of the eikonalization of the proton-proton amplitude in both the one- and two-channel eikonal models.

  18. A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

    DEFF Research Database (Denmark)

    Hertz, Emil Peter Thrane; Kruse, Thomas; Davey, Norman E

    2016-01-01

    -exposed pocket on PP2A regulatory B56 subunits binds to a consensus sequence on interacting proteins, which we term the LxxIxE motif. The composition of the motif modulates the affinity for B56, which in turn determines the phosphorylation status of associated substrates. Phosphorylation of amino acid residues...... a molecular description of PP2A binding specificity with broad implications for understanding signaling in eukaryotes....

  19. Mechanistic Analysis of AKT1 Regulation by the CBL-CIPK-PP2CA Interactions

    Institute of Scientific and Technical Information of China (English)

    Wen-Zhi Lan; Sung-Chul Lee; Yu-Fen Che; Yuan-Qing Jiang; Sheng Luan

    2011-01-01

    T Arabidopsis K+ transporter 1 (AKT1) participates in K+ uptake in roots, especially under low-K conditions. We recently identified a Ca2+ signaling pathway consisting of multiple calcineurin B-like calcium sensors (CBLs) and multiple target kinases (CBL-interacting protein kinases or CIPKs) that phosphorylate and activate AKT1, whereas a specific PP2C-type phosphatase inactivates CIPK-dependent AKT1 activity. In this study, we analyzed the interactions between PP2Cs and the CBL-CIPK pathway and found previously unsuspected mechanisms underlying the CBL-CIPK-PP2C signaling processes. The interaction between the CIPKs and PP2Cs involves the kinase domain of the CIPK component, in addition to the protein phosphatase interacting motif (PPI) in the regulatory domain. Furthermore, specific CBLs physically interact with and inactivate PP2C phosphatases to recover the CIPK-dependent AKT1 channel activity. These findings provide further insights into the signaling network consisting of CBL-CIPK-PP2C interactions in the activation of the AKT1 channel.

  20. Effect of Cold-Drawn Fibers on the Self-Reinforcement of PP/LDPE Composites

    Science.gov (United States)

    Zhou, Ying-Guo; Su, Bei; Wu, Hai-Hong

    2017-08-01

    In our previous study, a method to fabricate super-ductile polypropylene/low-density polyethylene (PP/LDPE) blends was proposed, and a fiber-shape structure was shown to be formed, presenting necking propagation during tensile testing. In this study, the mechanical properties and thermal behavior of the necking region of tested super-ductile PP/LDPE samples were carefully investigated and further compared with the melt-stretched, untested, and thermo-mechanical-history-removed samples by differential scanning calorimetry and tensile testing. The results suggest that the tested samples have high mechanical properties and are more thermo-mechanically stable than the common PP/LDPE blends and melt-stretched samples. Additionally, to investigate their structure-property relationship, the necking region of the tested samples was further characterized by scanning electron microscopy and hot-stage polarized light microscopy. It can be concluded that the variation of the microstructure can be attributed to the cold-drawn fibers (CDFs), which were more stable thermally, formed during the tensile test. Furthermore, the CDFs were used for the filler in PP/LDPE blends. The experimental results of the different PP/LDPE composites indicate that the CDFs are a good reinforcement candidate and have the ability to improve the mechanical properties of the PP/LDPE blends.

  1. New KF-PP-SVM classification method for EEG in brain-computer interfaces.

    Science.gov (United States)

    Yang, Banghua; Han, Zhijun; Zan, Peng; Wang, Qian

    2014-01-01

    Classification methods are a crucial direction in the current study of brain-computer interfaces (BCIs). To improve the classification accuracy for electroencephalogram (EEG) signals, a novel KF-PP-SVM (kernel fisher, posterior probability, and support vector machine) classification method is developed. Its detailed process entails the use of common spatial patterns to obtain features, based on which the within-class scatter is calculated. Then the scatter is added into the kernel function of a radial basis function to construct a new kernel function. This new kernel is integrated into the SVM to obtain a new classification model. Finally, the output of SVM is calculated based on posterior probability and the final recognition result is obtained. To evaluate the effectiveness of the proposed KF-PP-SVM method, EEG data collected from laboratory are processed with four different classification schemes (KF-PP-SVM, KF-SVM, PP-SVM, and SVM). The results showed that the overall average improvements arising from the use of the KF-PP-SVM scheme as opposed to KF-SVM, PP-SVM and SVM schemes are 2.49%, 5.83 % and 6.49 % respectively.

  2. EFFECT OF MOLECULAR WEIGHT OF PDMS ON MORPHOLOGY AND MECHANICAL PROPERTIES OF PP/PDMS BLENDS

    Institute of Scientific and Technical Information of China (English)

    Ze-yong Zhao; Wei-wei Yap; Rong-ni Du; Qin Zhang; Qiang Fu; Ze-hao Qiu; Su-lan Yuan

    2009-01-01

    A series of polydimethylsiloxane (PDMS) with varied molecular weights (Mw = 3x106,1x106 and 0.5x106)were melt blended with PP to investigate the effect of PDMS molecular weight (MW) on the morphology and mechanical properties of PP/PDMS blends.Scanning electron microscopic (SEM) examination showed that the size of PDMS domains was dependent on the MW of PDMS.It was found that the lower the value of PDMS MW,the better dispersion of the PDMS domains in the PP matrix.Tensile and Izod impact tests revealed that the addition of PDMS with lower MW would lead to a more significant increase in impact strength of the blends compared with the blends with higher MW ones,while the influence of the molecular weight on tensile strengths of the blends was relatively small in the MW range studied.Differential scanning calorimetry (DSC) results also showed that the crystallization temperature of PP was increased with decreasing PDMS MW,indicating a better nucleation capability of lower MW of PDMS.Melting flow rate (MFR)measurements indicated that the processibility of PP could be enhanced by adding PDMS,and again the lower MW PDMS resulted in better data.Our work demonstrates that not only the processibility but also the mechanical properties of PP could be enhanced to a more significant degree by using low MW PDMS than the higher ones.

  3. The role of SET/I2PP2A in canine mammary tumors.

    Science.gov (United States)

    Kake, Satoru; Tsuji, Shunya; Enjoji, Shuhei; Hanasaki, Sayaka; Hayase, Hiroshi; Yabe, Ryotaro; Tanaka, Yuiko; Nakagawa, Takayuki; Liu, Hao-Ping; Chang, Shih-Chieh; Usui, Tatsuya; Ohama, Takashi; Sato, Koichi

    2017-06-27

    Canine mammary tumor is the most common neoplasm in female dogs, and it has generated considerable attention as a translational model for human breast cancer. Ser/Thr protein phosphatase 2A (PP2A) plays a critical role as a tumor suppressor, and SET/I2PP2A, the endogenous inhibitory protein of PP2A, binds directly to PP2A and suppresses its phosphatase activity. Here, we investigated the role of SET in the tumorigenic growth in canine mammary tumor as well as in the sensitivity of tumors to existing therapeutics. Elevated protein levels of SET were observed in advanced-stage of canine mammary tumor tissues of dogs compared with paired normal tissues. Knockdown of SET expression in a canine mammary tumor cell line CIP-m led to increased PP2A activity and decreased cell proliferation, colony formation, and in vivo tumor growth. We observed suppression of mTOR, β-catenin, and NFκB signaling by SET knockdown. The sensitivity of CIP-m cells to doxorubicin was decreased by SET knockdown, while SET knockdown in CIP-m cells did not affect sensitivity to 4-OH-tamoxifen, carboplatin, bortezomib, and X-ray radiation. These data suggest that SET plays important roles in the tumor progression of a subset of canine mammary tumor by suppressing PP2A activity and enhancing mTOR, β-catenin, and NFκB signaling.

  4. Mechanical and thermal properties of PP/PBT blends compatibilized with triblock thermoplastic elastomer

    Directory of Open Access Journals (Sweden)

    Ignaczak Wojciech

    2015-09-01

    Full Text Available A linear triblock copolymer, poly(styrene-b-etylene/butylene-b-styrene(SEBS thermoplastic elastomer (TPE grafted with maleic anhydride was used for compatibilization of PP/PBT blends. PP/PBT blends of different mass ratios 60/40, 50/50, 40/60 were mixed with 2.5, 5.0 and 7.5 wt.% of SEBS copolymer in a twin screw extruder. Differential scanning calorimetry and dynamic mechanical analysis were performed to define the phase structure of PP/PBT blends. TPE with a rubbery mid-block shifted the glass transition of PP/PBT blend towards lower temperatures, and significant decrease the crystallization temperature of a crystalline phase of PP component was observed. The influence of the amount of compatibilizer and the blend composition on the mechanical properties (tensile and flexural strengths, toughness and moduli was determined. Addition of 5 wt.% of a triblock TPE led to a three-fold increase of PP/PBT toughness. A significant increase of impact properties was observed for all materials compatibilized with the highest amount of SEBS copolymer.

  5. The melt-recrystallization behavior of highly oriented α-iPP fibers embedded in a HIPS matrix.

    Science.gov (United States)

    Ye, Liwei; Li, Huihui; Qiu, Zhaobin; Yan, Shouke

    2015-03-21

    The melt-recrystallization behavior of α-iPP fibers embedded in an amorphous HIPS matrix has been studied by means of optical microscopy. The amorphous HIPS serving as a supporter of iPP fibers does not become involved in the nucleation and crystallization process of the molten highly oriented iPP fibers. It also does not provide any birefringence under the optical microscope with crossed polarizers. This enables the study of orientation-induced β-iPP crystallization through a control of the melting status of the fibers. Through melting the fibers at different temperatures above 175 °C and subsequent recrystallization, some β-iPP crystals were always produced. The content of the β-iPP crystal depends strongly on the melting temperature and melting time of the iPP fibers. It was confirmed that melting the iPP fibers at relatively lower temperature, e.g. 176 °C, less amount of β-iPP crystals were observed. The content of β-iPP crystal enhances first with increasing melting temperature and then decreases with further increase of the fiber melting temperature. The β-iPP crystallization is found to be most favorable upon melting the fibers at 178 °C for 2 min. This demonstrates the requirement of a certain chain or chain segment orientation for generating β-iPP crystallization on the one hand, while higher orientation of the iPP chains or chain segments encourages the growth of iPP crystals in the α-form on the other hand. This has been further confirmed by varying the melting time of the fiber at different temperatures, since relaxation of the iPP molecular chains at a fixed temperature is time dependent. Moreover, the complete transformation of α-iPP fibers in some local places into β-iPP crystals implies that the αβ-transition may not be required for the orientation-induced β-iPP crystallization.

  6. Many means to a common end: the intricacies of (p)ppGpp metabolism and its control of bacterial homeostasis.

    Science.gov (United States)

    Gaca, Anthony O; Colomer-Winter, Cristina; Lemos, José A

    2015-04-01

    In nearly all bacterial species examined so far, amino acid starvation triggers the rapid accumulation of the nucleotide second messenger (p)ppGpp, the effector of the stringent response. While for years the enzymes involved in (p)ppGpp metabolism and the significance of (p)ppGpp accumulation to stress survival were considered well defined, a recent surge of interest in the field has uncovered an unanticipated level of diversity in how bacteria metabolize and utilize (p)ppGpp to rapidly synchronize a variety of biological processes important for growth and stress survival. In addition to the classic activation of the stringent response, it has become evident that (p)ppGpp exerts differential effects on cell physiology in an incremental manner rather than simply acting as a biphasic switch that controls growth or stasis. Of particular interest is the intimate relationship of (p)ppGpp with persister cell formation and virulence, which has spurred the pursuit of (p)ppGpp inhibitors as a means to control recalcitrant infections. Here, we present an overview of the enzymes responsible for (p)ppGpp metabolism, elaborate on the intricacies that link basal production of (p)ppGpp to bacterial homeostasis, and discuss the implications of targeting (p)ppGpp synthesis as a means to disrupt long-term bacterial survival strategies.

  7. Investigating hadronic resonances in pp interactions with HADES

    Directory of Open Access Journals (Sweden)

    Przygoda Witold

    2015-01-01

    Full Text Available In this paper we report on the investigation of baryonic resonance production in proton-proton collisions at the kinetic energies of 1.25 GeV and 3.5 GeV, based on data measured with HADES. Exclusive channels npπ+ and ppπ0 as well as ppe+e− were studied simultaneously in the framework of a one-boson exchange model. The resonance cross sections were determined from the one-pion channels for Δ(1232 and N(1440 (1.25 GeV as well as further Δ and N* resonances up to 2 GeV/c2 for the 3.5 GeV data. The data at 1.25 GeV energy were also analysed within the framework of the partial wave analysis together with the set of several other measurements at lower energies. The obtained solutions provided the evolution of resonance production with the beam energy, showing a sizeable non-resonant contribution but with still dominating contribution of Δ(1232P33. In the case of 3.5 GeV data, the study of the ppe+e− channel gave the insight on the Dalitz decays of the baryon resonances and, in particular, on the electromagnetic transition form-factors in the time-like region. We show that the assumption of a constant electromagnetic transition form-factors leads to underestimation of the yield in the dielectron invariant mass spectrum below the vector mesons pole. On the other hand, a comparison with various transport models shows the important role of intermediate ρ production, though with a large model dependency. The exclusive channels analysis done by the HADES collaboration provides new stringent restrictions on the parameterizations used in the models.

  8. PP4 is essential for germinal center formation and class switch recombination in mice.

    Directory of Open Access Journals (Sweden)

    Ming-Yu Chen

    Full Text Available PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4 in mature B cells, we ablated the catalytic subunit of murine PP4 in vivo utilizing the CD23 promoter and cre-loxP recombination and generated CD23(crePP4(F/F mice. The development of follicular and marginal zone B cells was unaffected in these mutants, but the proliferation of mature PP4-deficient B cells stimulated by in vitro treatment with either anti-IgM antibody (Ab or LPS was partially impaired. Interestingly, the induction of CD80 and CD86 expression on these stimulated B cells was normal. Basal levels of serum Igs of all isotypes were strongly reduced in CD23(crePP4(F/F mice, and their B cells showed a reduced efficiency of class switch recombination (CSR in vitro upon stimulation by LPS or LPS plus IL-4. When CD23(crePP4(F/F mice were challenged with either the T cell-dependent antigen TNP-KLH or the T cell-independent antigen TNP-Ficoll, or by H1N1 virus infection, the mutant animals failed to form germinal centers (GCs in the spleen and the draining mediastinal lymph nodes, and did not efficiently mount antigen-specific humoral responses. In the resting state, PP4-deficient B cells exhibited pre-existing DNA fragmentation. Upon stimulation by DNA-damaging drug etoposide in vitro, mutant B cells showed increased cleavage of caspase 3. In addition, the mutant B cells displayed impaired CD40-mediated MAPK activation, abnormal IgM-mediated NF-κB activation, and reduced S phase entry upon IgM/CD40-stimulation. Taken together, our results establish a novel role for PP4 in CSR, and reveal crucial functions for PP4 in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.

  9. Molecular cloning, expression and functional analysis of three subunits of protein phosphatase 2A (PP2A) from black tiger shrimps (Penaeus monodon).

    Science.gov (United States)

    Zhao, Chao; Wang, Yan; Fu, Mingjun; Yang, Keng; Qiu, Lihua

    2017-02-01

    Protein phosphatase 2A (PP2A) is a cellular serine-threonine (Ser/Thr) phosphatase that plays a crucial role in regulating most cellular functions. In the present study, the full-length cDNAs of three subunits of PmPP2A (PmPP2A-A, PP2A-B and PP2A-C) were cloned from Penaeus monodon, which are the first available for shrimps. Sequence analysis showed that PmPP2A-A, PmPP2A-B and PmPP2A-C encoded polypeptides of 591, 443, and 324 amino acids, respectively. The mRNAs of three subunits of PmPP2A were expressed constitutively in all tissues examined, and predominantly in the ovaries. In ovarian maturation stages, the three subunits of PmPP2A were continuously but differentially expressed. Dopamine and 5-hydroxytryptamine injection experiments were conducted to study the expression profile of three subunits of PmPP2A, and the results indicated that PmPP2A played a negative regulatory role in the process of ovarian maturation. In addition, the recombinant proteins of three subunits of PmPP2A were successfully obtained, and the phosphatase activity of PmPP2A was tested in vitro. The results of this study will advance our understanding about the molecular mechanisms of PmPP2A in Penaeus monodon.

  10. PP/Talc/MA-SEBS复合材料的力学性能研究%The Mechanical Properties of PP/Talc/MA-SEBS Composite

    Institute of Scientific and Technical Information of China (English)

    谢晓春

    2011-01-01

    PP/Talc composites compatibilized by MA-SEBS(maleic anhydride grafted styrene-(ethylene-co-butylene)-styrene copolymer) were prepared by melt extrusion, followed by injection molding. The effects of Talc and MA-SEBS on mechanical properties of PP/Talc/MA-SEBS composites were systematically investigated. The results indicated that Talc mixing into PP could obviously improve the impact strength of PP at room temperature. After the entry of MA-SEBS to the PP/Talc composites, the impact strength increased even more. MA-SEBS acted as a toughening agent as well as a compatilizer, enhancing the toughening effect of Talc. The rigid Talc particles made the flexural strength increase markedly, and the flexural moduls go up with the increase of Talc content; and elastomer MA-SEBS got the flexural performance of composites obviously deteriorated. Talc had no bad effect on the PP tensile properties; if adding Talc and MA-SEBS at the same time,the tensile strength would go down, and tend to decrease with increasing MA-SEBS content in the composites.%选用MA-SEBS为增容剂,制备了PP/滑石粉(Talc)/MA-SEBS复合材料,研究了Talc和MA-SEBS的含量对复合材料力学性能的影响.结果表明,单纯加入一定量Talc可以明显提高PP冲击强度,再加入MA-SEBs后,复合材料的冲击强度进一步增加.MA-SEBS除了作为相容剂.也充当增韧剂.刚性粒子Talc使材料的弯曲强度明显增大,弯曲模量随Talc含量增加而增大;而弹性体MA-SEBS使材料弯曲性能明显变差.单纯加入Talc对PP的拉伸性能无负面影响;若同时加入Tak和MA-SEBS,材料的拉伸强度明显下降,且MA-SEBS含量越大降幅越大.

  11. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.

    Science.gov (United States)

    Saddoughi, Sahar A; Gencer, Salih; Peterson, Yuri K; Ward, Katherine E; Mukhopadhyay, Archana; Oaks, Joshua; Bielawski, Jacek; Szulc, Zdzislaw M; Thomas, Raquela J; Selvam, Shanmugam P; Senkal, Can E; Garrett-Mayer, Elizabeth; De Palma, Ryan M; Fedarovich, Dzmitry; Liu, Angen; Habib, Amyn A; Stahelin, Robert V; Perrotti, Danilo; Ogretmen, Besim

    2013-01-01

    Mechanisms that alter protein phosphatase 2A (PP2A)-dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor ceramide binds I2PP2A/SET selectively in the nucleus and including its K209 and Y122 residues as determined by molecular modelling/simulations and site-directed mutagenesis. Because I2PP2A/SET was found overexpressed, whereas ceramide was downregulated in lung tumours, a sphingolipid analogue drug, FTY720, was identified to mimick ceramide for binding and targeting I2PP2A/SET, leading to PP2A reactivation, lung cancer cell death, and tumour suppression in vivo. Accordingly, while molecular targeting of I2PP2A/SET by stable knockdown prevented further tumour suppression by FTY720, reconstitution of WT-I2PP2A/SET expression restored this process. Mechanistically, targeting I2PP2A/SET by FTY720 mediated PP2A/RIPK1-dependent programmed necrosis (necroptosis), but not by apoptosis. The RIPK1 inhibitor necrostatin and knockdown or genetic loss of RIPK1 prevented growth inhibition by FTY720. Expression of WT- or death-domain-deleted (DDD)-RIPK1, but not the kinase-domain-deleted (KDD)-RIPK1, restored FTY720-mediated necroptosis in RIPK1(-/-) MEFs. Thus, these data suggest that targeting I2PP2A/SET by FTY720 suppresses lung tumour growth, at least in part, via PP2A activation and necroptosis mediated by the kinase domain of RIPK1.

  12. PP/SEBS/MH复合材料的制备及其性能研究%Preparation and Characterization of PP/SEBS/MH Composite

    Institute of Scientific and Technical Information of China (English)

    陈志军; 黄年华; 周俊

    2011-01-01

    The flame retardancy,mechanical properties and the thermal degradation behaviour of polypropylene(PP)/hydrogenated styrene-butadiene-styrene block copolymer(SEBS)/ magnesium hydroxide(MH) composite were investigated by limiting oxygen index(LOI) method and thermogravimetric analysis(TGA).The results showed that the tensile strength,the fracture strength,the elongation at break and melt flow rate of PP/SEBS/MH composite decreased with increasing the mass fraction of MH.The flame retardancy and the thermal stability at high temperature were improved.The LOI value of PP/SEBS/MH composite was 26.3 % at the mass fraction of MH was 60 %.%采用极限氧指数(LOI)和热重分析(TGA)研究了聚丙烯(PP)/氢化苯乙烯-丁二烯-苯乙烯嵌段共聚物(SEBS)/氢氧化镁(MH)复合材料的阻燃性能和热降解行为;探讨了SEBS和MH分别对PP/SEBS共混体系和PP/SEBS/MH复合材料力学性能和熔体流动速率的影响。结果表明:PP/SEBS/MH复合材料的力学性能和加工流动性能随着MH的质量分数增加而降低;复合材料高温下的热稳定性得到提高,MH分解吸热降低材料的热降解速率;MH以吸热方式在凝缩相和气相中发挥阻燃作用,复合材料阻燃性能得到提高,当MH的质量分数为60%时,LOI可达26.3%。

  13. Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8.

    Science.gov (United States)

    Li, Gang; Xie, Fang; Zhang, Yanhe; Bossé, Janine T; Langford, Paul R; Wang, Chunlai

    2015-01-01

    Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated. The modified nucleotides guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and guanosine 5'-triphosphate 3'-diphosphate (pppGpp) are known to be signaling molecules in other prokaryotes. Here, to investigate the role of (p)ppGpp in A. pleuropneumoniae, we created a mutant A. pleuropneumoniae strain, S8ΔrelA, which lacks the (p)ppGpp-synthesizing enzyme RelA, and investigated its phenotype in vitro. S8ΔrelA did not survive after stationary phase (starvation condition) and grew exclusively as non-extended cells. Compared to the wild-type (WT) strain, the S8ΔrelA mutant had an increased ability to form a biofilm. Transcriptional profiles of early stationary phase cultures revealed that a total of 405 bacterial genes were differentially expressed (including 380 up-regulated and 25 down-regulated genes) in S8ΔrelA as compared with the WT strain. Most of the up-regulated genes are involved in ribosomal structure and biogenesis, amino acid transport and metabolism, translation cell wall/membrane/envelope biogenesis. The data indicate that (p)ppGpp coordinates the growth, viability, morphology, biofilm formation and metabolic ability of A. pleuropneumoniae in starvation conditions. Furthermore, S8ΔrelA could not use certain sugars nor produce urease which has been associated with the virulence of A. pleuropneumoniae, suggesting that (p)ppGpp may directly or indirectly affect the pathogenesis of A. pleuropneumoniae during the infection process. In summary, (p)ppGpp signaling represents an essential component of the regulatory network governing stress adaptation and virulence in A. pleuropneumoniae.

  14. Site Specificity of Cleavage of DSP-PP by BMP1

    Science.gov (United States)

    Yang, Robert T.; Lim, Glendale L.; Yee, Colin T.; Fuller, Robert S.; Ritchie, Helena H.

    2015-01-01

    Bone morphogenic protein 1 (BMP1), a metalloproteinase, is known to cleave a wide variety of extracellular matrix proteins, suggesting that a consensus substrate cleavage amino acid sequence might exist. However, while such a consensus sequence has been proposed based on P4 to P4′ (i.e., the four amino acids flanking either side of the BMP1 cleavage site; P4P3P2P1|P1′P2′P3′P4′) sequence homologies between two BMP1 substrates, dentin matrix protein 1 and dentin sialoprotein phosphophoryn (DSP-PP) (i.e., xMQx | DDP), no direct testing has so far been attempted. Using an Sf9 cell expression system, we have been able to produce large amounts of uncleaved DSP-PP,. Point mutations introduced into this recombinant DSP-PP were then tested for their affects on DSP-PP cleavage by either Sf9 endogenous tolloid-related protein 1 (TLR-1) or by its human homolog, BMP1. Here we have measured DSP-PP cleavage efficiencies after modifications based on P4-P4′ sequence comparisons with dentin matrix protein 1, as well as for prolysyl oxidase and chordin, two other BMP1 substrates. Our results demonstrate that any mutations within or outside of the DSP-PP P4 to P4′ cleavage site can block, impair or accelerate DSP-PP cleavage, and suggest that its BMP1 cleavage site is highly conserved in order to regulate its cleavage efficiency, possibly with additional assistance from its conserved exosites. Thus, BMP1 cleavage cannot be based on a consensus substrate cleavage site. PMID:25158199

  15. The effect of the compatibilizer SEBS-g-GMA on the blend PP-PET: virgin and recycled materials

    OpenAIRE

    Van Kets, Karen; Van Damme, Nicolas; Delva, Laurens; Ragaert, Kim

    2016-01-01

    Abstract. In the carpet industry poly(ethylene terephthalate) (PET) and poly(propylene) (PP) are often used together within a single product. Mechanical recycling of these carpets results in a blend of PET and PP, which are immiscible. To enhance impact strength of this waste stream, the compatibilizer SEBS-g-GMA was used. More specific the transferability of earlier results with the compatibilizer, obtained on virgin PET-PP blends with amorphous PET (PETg), was assessed. Firstly, from these ...

  16. Estudo do efeito da adição de PP reciclado nas propriedades mecânicas e de escoamento de misturas de PP/EPDM Study of the Effect of Recycled PP on the Mechanical and Flow Properties of PP/ERDM Blends

    Directory of Open Access Journals (Sweden)

    Luciene da S. Santos

    2013-01-01

    Full Text Available Misturas de polipropileno, PP, e terpolímero de etileno-propileno-dieno, EPDM, são amplamente utilizadas na indústria automobilística, principalmente em parachoques, cuja destinação, após o seu uso, deverá atender a Política Nacional de Resíduos Sólidos. No presente trabalho, o efeito da incorporação de PP reciclado nas propriedades mecânicas e de escoamento das misturas PP virgem/EPDM foi avaliado através de um planejamento fatorial do tipo 2n, com n = 3 fatores: teor de PP reciclado, perfil de temperatura de processamento e velocidade de rotação da rosca. As variáveis de resposta analisadas foram: módulo de Young, resistência ao impacto e índice de fluidez (MFI. Os resultados mostraram que o aumento da temperatura de processamento tende a aumentar a rigidez, a resistência ao impacto e a fluidez do produto final. O aumento da velocidade de mistura mostrou uma influência mais significativa na resistência ao impacto do material; enquanto o aumento do teor de reciclado na mistura PP virgem/EPDM levou ao aumento das propriedades mecânicas, bem como do índice de fluidez do produto.Polypropylene, PP, and ethylene propylene diene copolymer (EPDM blends are widely used in automotive industry, mainly in bumpers. Their disposal should comply with the rules of the Solid Residue National Policy. In the present study, the effect of recycled PP addition on the mechanical and flow properties of these blends was evaluated using a 2n factorial design, with n = 3 factors: recycled PP content, extrusion temperature profile and screw speed. The parameters analyzed were: Young modulus, impact strength and melt flow index (MFI. The results showed that the increase in temperature tends to increase rigidity, impact strength and the flow of the final product. The increase in blend speed showed a significant influence on the impact strength of the material; whereas the increase in recycled PP content led to an increase of the mechanical

  17. PREPARATION AND CHARACTERIZATION OF SPHERICAL PP/PB ALLOYS WITH MgCl2-SUPPORTED ZIEGLER-NATTA CATALYST

    Institute of Scientific and Technical Information of China (English)

    Ai-hua He; Yang-wei Shi; Guo-qing Liu; Wei Yao; Bao-chen Huang

    2012-01-01

    Polypropylene (PP)/polybutene-1 (PB) alloys within reactor were prepared by MgCl2-supported Ziegler-Natta catalyst with sequential two-stage polymerization technology.First,propylene homo-polymerizations were carried out to form isotactic polypropylene (iPP) particles containing active catalyst.Then,butene-1 was subsequently polymerized to form polybutene-1 phase inside the iPP particles.Finally,iPP/PB alloys with spherical shape and adjustable PB content were synthesized.The catalytic activity and catalytic stereospecificity of the Z-N catalyst in the two-stage polymerization process are discussed.The composition and physical properties of the PP alloys were characterized by FT-IR,13C-NMR,SEM,DSC and XRD.It was found that the in-reactor PP alloys are mainly composed of PP and PB with a little amount of poly(buteneco-propylene) random copolymers and poly(butene-block-propylene) block copolymers.SEM measurements verified that the PB phases with size in the range of 300-400 nm dispersed in the PP matrix uniformly.The incorporation of PB upon the PP matrix affects the properties of final products greatly.

  18. SYNERGISTIC EFFECT OF Cu-ZSM-5 ZEOLITE ON FLAME RETARDED PP BY MELAMINE SALT OF DIPENTAERYTHRIOL PHOSPHATE

    Institute of Scientific and Technical Information of China (English)

    Jing Gu; Dao Li; Wei-wei Liao; Yuan Li; Xing-yi Wang

    2009-01-01

    A novel intumnescent flame melamine salt of dipentaerythriol phosphate (MDP),was prepared from dipentaerythritol (DPE) polyphosphoric acid,and melamine.The flammability,combustion behavior,and thermal degradation and stability of PP-MDP were characterized.When MDP loading was 20 wt%,LOI values of the composites reached up to 27%,and UL94 rating,V-2.PP-MDP containing 1 wt% Cu-ZSM-5 presented the highest LOI value of 30.5% and UL94 rating,V-0,and released lest heat during cone test.TG data showed that the thermal degradation of PP was improved by the addition of MDP.While the loading of ZSM-5 was 1 wt% or higher,the main weight loss delayed with 50℃,and 80℃,compared with PP and PP-MDP respectively.The appropriate loading Cu-ZSM-5 made PP-MDP possess higher thermal oxidative stability.By SEM,the formation of a dense and thick char layer was observed on the char layer of PP-MDP-containing Cu-ZSM-5,responsible for high flame retardancy.So,the synergistic flame retardancy effects of MDP and Cu-ZSM-5 on PP existed.The mechanism of synergistic effect of Cu-ZSM-5 zeolite on flame retarded PP by MDP was discussed.

  19. Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency

    Energy Technology Data Exchange (ETDEWEB)

    Jin Jing [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Jiang Wei, E-mail: wjiang@ciac.jl.cn [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Shi Qiang [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Zhao Jie [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Graduate University of Chinese Academy of Sciences, Beijing 100049 (China); Yin Jinghua, E-mail: yinjh@ciac.jl.cn [State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China); Stagnaro, Paola [Istituto per Io Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Via de Marini 6, 16149 Genova (Italy)

    2012-05-15

    We described a two-step process to fabricate the heparinized polypropylene (PP) film using cyanuric chloride (CC) as a trifunctional reagent and poly (ethylene glycol) methacrylate (PEGMA) as a spacer. The modified PP films were characterized by attenuated total reflectance FT-IR and X-ray photoelectron spectroscopy; the content of PEGMA and heparin were determined by gravimetric method and a toluidine blue assay, respectively. For the PP-g-PEGMA films, it was found that small size protein BSA tended to adsorb on the surface of low molecular weight monomer grafted PP, whereas big spindle-shaped fibrinogen tended to adsorb on the surface of high molecular weight monomer grafted PP. We gave a definition of anti-protein adsorptive factor r with two model proteins, albumin and fibrinogen. The results by platelet adhesion and plasma recalcification time (PRT) experiments indicated that the factor r could be used to quantitatively evaluate the anticoagulant tendency of PP-g-PEGMA modified films. For the PP-g-PEGMA-g-heparin modified films, the surface was proved to have a high bioactivity by the adsorption of AT III assay and very low platelet adhesion. It indicated that immobilization of heparin on the PP film with PEGMA as a spacer was an effective way to improve the hemocompatibility of PP.

  20. Fabrication of PP-g-PEGMA-g-heparin and its hemocompatibility: From protein adsorption to anticoagulant tendency

    Science.gov (United States)

    Jin, Jing; Jiang, Wei; shi, Qiang; Zhao, Jie; Yin, Jinghua; Stagnaro, Paola

    2012-05-01

    We described a two-step process to fabricate the heparinized polypropylene (PP) film using cyanuric chloride (CC) as a trifunctional reagent and poly (ethylene glycol) methacrylate (PEGMA) as a spacer. The modified PP films were characterized by attenuated total reflectance FT-IR and X-ray photoelectron spectroscopy; the content of PEGMA and heparin were determined by gravimetric method and a toluidine blue assay, respectively. For the PP-g-PEGMA films, it was found that small size protein BSA tended to adsorb on the surface of low molecular weight monomer grafted PP, whereas big spindle-shaped fibrinogen tended to adsorb on the surface of high molecular weight monomer grafted PP. We gave a definition of anti-protein adsorptive factor r with two model proteins, albumin and fibrinogen. The results by platelet adhesion and plasma recalcification time (PRT) experiments indicated that the factor r could be used to quantitatively evaluate the anticoagulant tendency of PP-g-PEGMA modified films. For the PP-g-PEGMA-g-heparin modified films, the surface was proved to have a high bioactivity by the adsorption of AT III assay and very low platelet adhesion. It indicated that immobilization of heparin on the PP film with PEGMA as a spacer was an effective way to improve the hemocompatibility of PP.

  1. Study of the structure and the mechanical properties of dynamically cured PP/MAH-g-SEBS/epoxy blends

    Institute of Scientific and Technical Information of China (English)

    Xue Liang Jiang; Yin Xi Zhang

    2009-01-01

    A new method concerning with the simultaneous reinforcing and toughening of polypropylene (PP) was reported. Dynamical cure of the epoxy resin was successfully applied in the PP/maleic anhydride-grafted styrene--ethylene-butylene-styrene (SEBS) triblock copolymer, and the obtained blends named as dynamically cured PP/MAH-g-SEBS/epoxy blends. The stiffness and toughness of the blends are in a good balance, and MAH-g-SEBS was acted as not only an impact modifier but also a compatibilizer. The structure of the dynamically cured PP/MAH-g-SEBS/epoxy blends is the embedding of the epoxy particles by the MAH-gSEBS.

  2. EPR study of the formation of radicals in PP with antioxidants irradiated with gamma rays

    Energy Technology Data Exchange (ETDEWEB)

    Silva, P. [Instituto Venezolano de Investigaciones Cientificas, Centro de Fisica, Carretera Panamericana Km. 11, Caracas 1020-A (Venezuela)], E-mail: silva@ivic.ve; Albano, C. [Instituto Venezolano de Investigaciones Cientificas, Centro de Quimica, Universidad Central de Venezuela, Facultad de Ingenieria (Venezuela); Perera, R. [Departamento de Mecanica, Universidad Simon Bolivar (Venezuela)

    2007-12-15

    The behavior of different compounds of polypropylene (PP) with stabilizers such as buthyl-hydroxy-toluene (BHT), Chimassorb 944 (Hals) (CHIM), and a copolymer of styrene-butadiene-styrene (SBS) was studied using electron paramagnetic resonance (EPR). A characteristic spectra for pure PP irradiated in air was obtained for all the samples just after being irradiated [M. Dole, The Radiation Chemistry of Macromolecules, Vol. 2, Academic Press, 1973]. A change in the lineshape of the spectra from a pure PP's EPR signal to that of nitroxyl radical as a function of time was observed. The total free radical concentration (TFRC) decayed until approximately 800 h in the PP-HALS and until around 2000 h in all other cases, when the TFRC began to increase in all the cases, except in that of PP-BHT. In this last case, the EPR signal was not detectable after 4000 h. The BHT and the SBS diluted the free radical concentrations, being them smaller when they are present. The behavior observed in all the samples is consistent with the formation of nitroxyl radicals by gamma rays.

  3. Single-pion production in pp collisions at 0.95 GeV/c (II)

    Energy Technology Data Exchange (ETDEWEB)

    Abd El-Samad, S. [Atomic Energy Authority NRC Cairo, Cairo (Egypt); Bilger, R.; Clement, H.; Dietrich, M.; Doroshkevich, E.; Ehrhardt, K.; Erhardt, A.; Kress, J.; Meier, R.; Wagner, G.J.; Weidlich, U.; Zhang, G. [Physikalisches Institut der Universitaet Tuebingen, Tuebingen (Germany); Brinkmann, K.T.; Freiesleben, H.; Jaekel, R.; Jakob, B.; Karsch, L.; Kuhlmann, E.; Schulte-Wissermann, M.; Sun, G.Y. [Technische Universitaet Dresden, Dresden (Germany); Dshemuchadse, S. [Technische Universitaet Dresden, Dresden (Germany); Forschungszentrum Rossendorf, Dresden (Germany); Eyrich, W.; Hauffe, J.; Schroeder, W.; Stinzing, F.; Waechter, J.; Wagner, M.; Wirth, S. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen-Nuernberg (Germany); Filippi, A.; Marcello, S. [University of Torino (Italy); INFN, Sezione di Torino, Torino (Italy); Fritsch, M. [Ruhr-Universitaet Bochum, Bochum (Germany); Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen-Nuernberg (Germany); Geyer, R.; Gillitzer, A.; Hesselbarth, D.; Kilian, K.; Marwinski, S.; Morsch, H.P.; Ritman, J.; Roderburg, E. [Forschungszentrum Juelich, Juelich (Germany); Moeller, K.; Naumann, L. [Forschungszentrum Rossendorf, Dresden (Germany); Schoenmeier, P. [Technische Universitaet Dresden, Dresden (Germany); Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen-Nuernberg (Germany); Wilms, A. [Ruhr-Universitaet Bochum, Bochum (Germany)

    2009-03-15

    The single-pion production reactions pp{yields}d{pi}{sup +}, pp{yields}np{pi}{sup +} and pp{yields}pp{pi}{sup 0} were measured at a beam momentum of 0.95GeV/c (T{sub p}{approx}400 MeV) using the short version of the COSY-TOF spectrometer. The central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements from other detector parts. Thus all pion production channels were recorded with 1-4 overconstraints. The main emphasis is put on the presentation and discussion of the np{pi}{sup +} channel, since the results on the other channels have already been published previously. The total and differential cross-sections obtained are compared to theoretical calculations. In contrast to the pp{pi}{sup 0} channel we observe in the np{pi}{sup +} channel a strong influence of the {delta} excitation. In particular, the pion angular distribution exhibits a (3 cos{sup 2}{theta}+1)-dependence, typical for a pure s-channel {delta} excitation and identical to that observed in the d{pi}{sup +} channel. Since the latter is understood by a s-channel resonance in the {sup 1} D{sub 2}pn partial wave, we discuss an analogous scenario for the pn{pi}{sup +} channel. (orig.)

  4. Single-pion production in pp collisions at 0.95 GeV/c (I)

    Energy Technology Data Exchange (ETDEWEB)

    Abd El-Samad, S. [Atomic Energy Authority NRC, Cairo (Egypt); Bilger, R.; Clement, H.; Dietrich, M.; Doroshkevich, E.; Erhardt, A.; Kress, J.; Meier, R.; Wagner, G.J.; Weidlich, U.; Zhang, G. [Physikalisches Institut der Universitaet Tuebingen, Tuebingen (Germany); Brinkmann, K.T.; Freiesleben, H.; Jaekel, R.; Jakob, B.; Karsch, L.; Kuhlmann, E.; Schulte-Wissermann, M.; Sun, G.Y. [Technische Universitaet Dresden (Germany); Dshemuchadse, S. [Forschungszentrum Rossendorf (Germany); Technische Univ. Dresden (Germany); Eyrich, W.; Hauffe, J.; Schroeder, W.; Stinzing, F.; Waechter, J.; Wagner, M.; Wirth, S. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg (Germany); Filippi, A.; Marcello, S. [University of Torino and INFN, Sezione di Torino (Italy); Fritsch, M. [Erlangen-Nuernberg Univ. (Germany); Ruhr-Univ. Bochum (Germany); Geyer, R.; Gillitzer, A.; Hesselbarth, D.; Kilian, K.; Marwinski, S.; Morsch, H.P.; Roderburg, E. [Forschungszentrum Juelich (Germany); Koch, H.; Steinke, M.; Wilms, A. [Ruhr-Universitaet Bochum (Germany); Moeller, K.; Naumann, L. [Forschungszentrum Rossendorf (Germany); Schoenmeier, P. [Technische Univ. Dresden (Germany); Erlangen-Nuernberg Univ. (Germany)

    2006-11-15

    The single-pion production reactions pp{yields}d{pi}{sup +}, pp{yields}np{pi}{sup +} and pp{yields}pp{pi}{sup 0} were measured at a beam momentum of 0.95 GeV/c (T{sub p}{approx}400 MeV) using the short version of the COSY-TOF spectrometer. The implementation of a central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements. Thus, all pion production channels were recorded with 1-4 overconstraints. The total and differential cross-sections obtained are compared to previous data and theoretical calculations. Main emphasis is put on the discussion of the pp{pi}{sup 0} channel, where we obtain angular distributions different from previous experimental results, however, partly in good agreement with recent phenomenological and theoretical predictions. In particular, we observe very large anisotropies for the {pi}{sup 0} angular distributions in the kinematical region of small relative proton momenta revealing there a dominance of proton spinflip transitions associated with {pi}{sup 0} s and d partial waves and emphasizing the important role of {pi}{sup 0} d-waves. (orig.)

  5. Single-Pion Production in pp Collisions at =.95 GeV/c (I)

    CERN Document Server

    El-Samad, S A; Brinkmann, K T; Clement, H; Dietrich, M; Doroshkevich, E; Dshemuchadze, S V; Erhardt, A; Eyrich, W; Filippi, A; Freiesleben, H; Fritsch, M; Geyer, R; Gillitzer, A; Hauffe, J; Hesselbarth, D; Jaekel, R; Jakob, B; Karsch, L; Kilian, K; Koch, H; Kress, J; Kuhlmann, E; Marcello, S; Marwinski, S; Meier, R; Möller, K; Morsch, H P; Naumann, Lutz; Roderburg, E; Schoenmeier, P; Schulte-Wissermann, M; Schroeder, W; Steinke, M; Stinzing, F; Sun, G Y; Waechter, J; Wagner, G J; Wagner, M; Weidlich, U; Wilms, A; Wirth, S; Zhang, G; Zupranski, P

    2006-01-01

    The single-pion production reactions $pp\\to d\\pi^+$, $pp\\to np\\pi^+$ and $pp\\to pp\\pi^0$ were measured at a beam momentum of 0.95 GeV/c ($T_p \\approx$ 400 MeV) using the short version of the COSY-TOF spectrometer. The implementation of a central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements. Thus all pion production channels were recorded with 1-4 overconstraints. The total and differential cross sections obtained are compared to previous data and theoretical calculations. Main emphasis is put on the discussion of the $pp\\pi^0$ channel, where we obtain angular distributions different from previous experimental results, however, partly in good agreement with recent phenomenological and theoretical predictions. In particular we observe very large anisotropies for the $\\pi^0$ angular distributions in the kinematical region of small relative proton momenta revealing there a dominance of proton spinflip transitions asso...

  6. Single-Pion Production in pp Collisions at 0.95 GeV/c (II)

    CERN Document Server

    El-Samad, S Abd; Brinkmann, K Th; Clement, H; Dietrich, M; Doroshkevich, E; Dshemuchadse, S; Ehrhardt, K; Erhardt, A; Eyrich, W; Filippi, A; Freiesleben, H; Fritsch, M; Geyer, R; Gillitzer, A; Hauffe, J; Hesselbarth, D; Jaekel, R; Jakob, B; Karsch, L; Kilian, K; Kress, J; Kuhlmann, E; Marcello, S; Marwinski, S; Meier, R; Möller, K; Morsch, H P; Naumann, Lutz; Ritman, J; Roderburg, E; Schoenmeier, P; Schulte-Wissermann, M; Schroeder, W; Stinzing, F; Sun, G Y; Waechter, J; Wagner, G J; Wagner, M; Weidlich, U; Wilms, A; Wirth, S; Zhang, G; Zupranski, P

    2008-01-01

    The single-pion production reactions $pp\\to d\\pi^+$, $pp\\to np\\pi^+$ and $pp\\to pp\\pi^0$ were measured at a beam momentum of 0.95 GeV/c ($T_p \\approx$ 400 MeV) using the short version of the COSY-TOF spectrometer. The central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements from other detector parts. Thus all pion production channels were recorded with 1-4 overconstraints. Main emphasis is put on the presentation and discussion of the $np\\pi^+$ channel, since the results on the other channels have already been published previously. The total and differential cross sections obtained are compared to theoretical calculations. In contrast to the $pp\\pi^0$ channel we find in the $np\\pi^+$ channel a strong influence of the $\\Delta$ excitation already at this energy close to threshold. In particular we find a $(3 cos^2\\Theta + 1)$ dependence in the pion angular distribution, typical for a pure s-channel $\\Delta$ excitation a...

  7. Study of Thermal Properties of Mixed (PP/EPR/ABS with Five Model Compatibilizers

    Directory of Open Access Journals (Sweden)

    Pierre Marcel Anicet Noah

    2016-01-01

    Full Text Available The influences of incorporating compatibilizers E-EA-MAH, E-MA-GMA, E-AM, SEBS KRATON G, or PP-g-MAH on the thermal properties of mixed (polypropylene/ethylene propylene rubber/acrylonitrile butadiene styrene (PP/EPR/ABS have been investigated. DSC investigations have revealed that the incorporation of 5% of ABS in the copolymer (PP/EPR does not fundamentally affect the thermal properties of the basic copolymer; additionally, the addition of 1.5% of each of the compatibilizers in the basic mixture does not significantly alter the crystallization temperature values and the melting of the -P- sequences. There is a variation of melting enthalpy values of the -P- sequences of 18.23% using SEBS KRATON G and of 10.38% using E-AM-GMA. When the rate of each of the compatibilizers increases to 5%, overall crystallization enthalpies of -P- sequences are almost kept unchanged, except for the case of using the compatibilizer E-AM-GMA with a variation of 8.42%. There is a minor variation of the melting enthalpy of -P- sequences with higher levels of compatibilizer. The incorporation of 5% ABS copolymer in the PP/EPR does not significantly alter the thermal properties of the basic structure of (PP/EPR/ABS.

  8. Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation.

    Science.gov (United States)

    Yang, Cui-Cui; Kuai, Xue-Xian; Li, Ya-Li; Zhang, Li; Yu, Jian-Chun; Li, Lin; Zhang, Lan

    2013-01-01

    Aim. The aim of the present study was to investigate the effect of cornel iridoid glycoside (CIG) on tau hyperphosphorylation induced by wortmannin (WT) and GF-109203X (GFX) and the underlying mechanisms. Methods. Human neuroblastoma SK-N-SH cells were preincubated with CIG (50, 100, and 200 µg/ml, resp.) for 24 h and then exposed to 10 µM WT and 10 µM GFX for 3 h after washing out CIG. Immunohistochemistry was used to observe the microtubular cytoskeleton of the cultured cells. Western blotting was used to measure the phosphorylation level of tau protein, glycogen synthase kinase 3 β (GSK-3 β ), and protein phosphatase 2A (PP2A). The activity of PP2A was detected by a biochemical assay. Results. Preincubation of CIG significantly attenuated the WT/GFX-induced tau hyperphosphorylation at the sites of Thr205, Thr212, Ser214, Thr217, Ser396, and PHF-1 and improved the damage of morphology and microtubular cytoskeleton of the cells. CIG did not prevent the decrease in p-AKT-ser473 and p-GSK-3 β -ser9 induced by WT/GFX. However, CIG significantly elevated the activity of PP2A by reducing the demethylation of PP2A catalytic subunit (PP2Ac) at Leu309 and the ratio of PME-1/LCMT in the WT/GFX-treated cells. The results suggest that CIG may be beneficial to the treatment of AD.

  9. Single-pion production in pp collisions at 0.95 GeV/c (II)

    Science.gov (United States)

    Abd El-Samad, S.; Bilger, R.; Brinkmann, K.-Th.; Clement, H.; Dietrich, M.; Doroshkevich, E.; Dshemuchadse, S.; Ehrhardt, K.; Erhardt, A.; Eyrich, W.; Filippi, A.; Freiesleben, H.; Fritsch, M.; Geyer, R.; Gillitzer, A.; Hauffe, J.; Hesselbarth, D.; Jaekel, R.; Jakob, B.; Karsch, L.; Kilian, K.; Kress, J.; Kuhlmann, E.; Marcello, S.; Marwinski, S.; Meier, R.; Möller, K.; Morsch, H. P.; Naumann, L.; Ritman, J.; Roderburg, E.; Schönmeier, P.; Schulte-Wissermann, M.; Schroeder, W.; Stinzing, F.; Sun, G. Y.; Wächter, J.; Wagner, G. J.; Wagner, M.; Weidlich, U.; Wilms, A.; Wirth, S.; Zhang, G.; Zupranski, P.

    2009-03-01

    The single-pion production reactions pp rightarrow d π+_{} , pp rightarrow np π+_{} and pp rightarrow pp π0_{} were measured at a beam momentum of 0.95GeV/c ( T p ≈ 400 MeV) using the short version of the COSY-TOF spectrometer. The central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements from other detector parts. Thus all pion production channels were recorded with 1-4 overconstraints. The main emphasis is put on the presentation and discussion of the np π+_{} channel, since the results on the other channels have already been published previously. The total and differential cross-sections obtained are compared to theoretical calculations. In contrast to the pp π0_{} channel we observe in the np π+_{} channel a strong influence of the Δ excitation. In particular, the pion angular distribution exhibits a (3 cos2 Θ + 1) -dependence, typical for a pure s -channel Δ excitation and identical to that observed in the d π+_{} channel. Since the latter is understood by a s -channel resonance in the 1 D 2 pn partial wave, we discuss an analogous scenario for the pn π+_{} channel.

  10. Single-pion production in pp collisions at 0.95 GeV/c (I)

    Science.gov (United States)

    Abd El-Samad, S.; Bilger, R.; Brinkmann, K.-Th.; Clement, H.; Dietrich, M.; Doroshkevich, E.; Dshemuchadse, S.; Erhardt, A.; Eyrich, W.; Filippi, A.; Freiesleben, H.; Fritsch, M.; Geyer, R.; Gillitzer, A.; Hauffe, J.; Hesselbarth, D.; Jaekel, R.; Jakob, B.; Karsch, L.; Kilian, K.; Koch, H.; Kress, J.; Kuhlmann, E.; Marcello, S.; Marwinski, S.; Meier, R.; Möller, K.; Morsch, H. P.; Naumann, L.; Roderburg, E.; Schönmeier, P.; Schulte-Wissermann, M.; Schroeder, W.; Steinke, M.; Stinzing, F.; Sun, G. Y.; Wächter, J.; Wagner, G. J.; Wagner, M.; Weidlich, U.; Wilms, A.; Wirth, S.; Zhang, G.; Zupranski, P.

    2006-11-01

    The single-pion production reactions pp → dπ+, pp → npπ+ and ppppπ0 were measured at a beam momentum of 0.95GeV/c ( T p ≈ 400MeV) using the short version of the COSY-TOF spectrometer. The implementation of a central calorimeter provided particle identification, energy determination and neutron detection in addition to time-of-flight and angle measurements. Thus, all pion production channels were recorded with 1-4 overconstraints. The total and differential cross-sections obtained are compared to previous data and theoretical calculations. Main emphasis is put on the discussion of the ppπ0 channel, where we obtain angular distributions different from previous experimental results, however, partly in good agreement with recent phenomenological and theoretical predictions. In particular, we observe very large anisotropies for the π0 angular distributions in the kinematical region of small relative proton momenta revealing there a dominance of proton spinflip transitions associated with π0 s and d partial waves and emphasizing the important role of π0 d-waves.

  11. Protein phosphatase 1 (PP1 is a post-translational regulator of the mammalian circadian clock.

    Directory of Open Access Journals (Sweden)

    Isabelle Schmutz

    Full Text Available Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours. Many clock proteins undergo circadian cycles of post-translational modifications. Among these modifications, protein phosphorylation plays an important role in regulating activity, stability and intracellular localization of clock components. Several protein kinases were characterized as regulators of the circadian clock. However, the function of protein phosphatases, which balance phosphorylation events, in the mammalian clock mechanism is less well understood. Here, we identify protein phosphatase 1 (PP1 as regulator of period and light-induced resetting of the mammalian circadian clock. Down-regulation of PP1 activity in cells by RNA interference and in vivo by expression of a specific inhibitor in the brain of mice tended to lengthen circadian period. Moreover, reduction of PP1 activity in the brain altered light-mediated clock resetting behavior in mice, enhancing the phase shifts in either direction. At the molecular level, diminished PP1 activity increased nuclear accumulation of the clock component PER2 in neurons. Hence, PP1, may reduce PER2 phosphorylation thereby influencing nuclear localization of this protein. This may at least partially influence period and phase shifting properties of the mammalian circadian clock.

  12. PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.

    Science.gov (United States)

    Kitagawa, Daiju; Flückiger, Isabelle; Polanowska, Jolanta; Keller, Debora; Reboul, Jérôme; Gönczy, Pierre

    2011-04-19

    Centrosome duplication occurs once per cell cycle and ensures that the two resulting centrosomes assemble a bipolar mitotic spindle. Centriole formation is fundamental for centrosome duplication. In Caenorhabditis elegans, the evolutionarily conserved proteins SPD-2, ZYG-1, SAS-6, SAS-5, and SAS-4 are essential for centriole formation, but how they function is not fully understood. Here, we demonstrate that Protein Phosphatase 2A (PP2A) is also critical for centriole formation in C. elegans embryos. We find that PP2A subunits genetically and physically interact with the SAS-5/SAS-6 complex. Furthermore, we show that PP2A-mediated dephosphorylation promotes centriolar targeting of SAS-5 and ensures SAS-6 delivery to the site of centriole assembly. We find that PP2A is similarly needed for the presence of HsSAS-6 at centrioles and for centriole formation in human cells. These findings lead us to propose that PP2A-mediated loading of SAS-6 proteins is critical at the onset of centriole formation.

  13. Enzymatic and molecular characterization of Arabidopsis ppGpp pyrophosphohydrolase, AtNUDX26.

    Science.gov (United States)

    Ito, Daisuke; Kato, Takahiro; Maruta, Takanori; Tamoi, Masahiro; Yoshimura, Kazuya; Shigeoka, Shigeru

    2012-01-01

    Not only in bacteria but also in plant cells, guanosine-3',5'-tetraphosphate (ppGpp) is an important signaling molecule, that affects various cellular processes. In this study, we identified nucleoside diphosphates linked to some moiety X (Nudix) hydrolases, AtNUDX11, 15, 25, and 26, having ppGpp pyrophosphohydrolase activity from Arabidopsis plants. Among these, AtNUDX26 localized in chloroplasts had the highest Vmax and kcat values, leading to high catalytic efficiency, kcat/Km. The activity of AtNUDX26 required Mg2+ or Mn2+ ions as cofactor and was optimal at pH 9.0 and 50 °C. The expression of AtNUDX26 and of ppGpp metabolism-associated genes was regulated by various types of stress, suggesting that AtNUDX26 regulates cellular ppGpp levels in response to stress and impacts gene expression in chloroplasts. This is the first report on the molecular properties of ppGpp pyrophosphohydrolases in plants.

  14. Characterisation and expression of a PP1 serine/threonine protein phosphatase (PfPP1 from the malaria parasite, Plasmodium falciparum: demonstration of its essential role using RNA interference

    Directory of Open Access Journals (Sweden)

    Musiyenko Alla

    2002-04-01

    Full Text Available Abstract Background Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members of the PP1 family represent the most highly conserved protein phosphatase sequences in phylogeny and play essential regulatory roles in various cellular pathways. Previous evidence suggested a PP1-like activity in Plasmodium falciparum, not yet identified at the molecular level. Results We have identified a PP1 catalytic subunit from P. falciparum and named it PfPP1. The predicted primary structure of the 304-amino acid long protein was highly similar to PP1 sequences of other species, and showed conservation of all the signature motifs. The purified recombinant protein exhibited potent phosphatase activity in vitro. Its sensitivity to specific phosphatase inhibitors was characteristic of the PP1 class. The authenticity of the PfPP1 cDNA was further confirmed by mutational analysis of strategic amino acid residues important in catalysis. The protein was expressed in all erythrocytic stages of the parasite. Abrogation of PP1 expression by synthetic short interfering RNA (siRNA led to inhibition of parasite DNA synthesis. Conclusions The high sequence similarity of PfPP1 with other PP1 members suggests conservation of function. Phenotypic gene knockdown studies using siRNA confirmed its essential role in the parasite. Detailed studies of PfPP1 and its regulation may unravel the role of reversible protein phosphorylation in the signalling pathways of the parasite, including glucose metabolism and parasitic cell division. The use of siRNA could be an important tool in the functional analysis of Apicomplexan genes.

  15. Physics at the FCC-hh, a 100 TeV pp collider

    CERN Document Server

    2017-01-01

    A 100 TeV pp collider is under consideration, by the high-energy physics community, as an important step for the future development of our field, following the completion of the LHC and High-luminosity LHC physics programmes. In particular, CERN is considering 100 TeV pp collisions as the key target of a Future Circular Collider facility, built around a 100 km tunnel and designed to deliver pp, e+e- and ep collisions, in addition to a programme with heavy ion beams and with the injector complex. CERN is coordinating an international study tasked with the completion, by the end of 2018, of a Conceptual Design Report (CDR) for this facility. This document presents the first results of the assessment of the physics potential of the hadronic part of this research programme (FCC-hh).

  16. Longitudinal scaling of net-protons in AuAu and pp collisions at RHIC energies

    Science.gov (United States)

    Videbaek, Flemming

    2008-10-01

    BRAHMS has studied net-protons distributions in Au+Au and p+p collisions at √sNN=62.4 and 200 GeV. Net-proton distributions reflect the net-baryon yields and can be used to extract the nuclear stopping in the collisions, thus providing information on baryon number transport and energy available for particle production. The talk will present final and preliminary results from the above mentioned systems. It will be shown that in p+p and in Au+Au central collisions that net-proton distributions exhibit longitudinal scaling once the target contribution to the projectile rapidity range is corrected for. The difference between p+p and Au+Au will be discussed. Aspects of future measurements at the LHC of net-baryons at mid-rapidity will be brought forth.

  17. Completeness of general pp-wave spacetimes and their impulsive limit

    CERN Document Server

    Sämann, Clemens; Švarc, Robert

    2016-01-01

    We investigate geodesic completeness in the full family of pp-wave or Brinkmann spacetimes in their extended as well as in their impulsive form. This class of geometries contains the recently studied gyratonic pp-waves, modelling the exterior field of a spinning beam of null particles, as well as NPWs, which generalise classical pp-waves by allowing for a general wave surface. The problem of geodesic completeness reduces to the question of completeness of trajectories on a Riemannian manifold under an external force field. Building upon respective recent results we derive completeness criteria in terms of the spatial asymptotics of the profile function in the extended case. In the impulsive case we use a fixed point argument to show that irrespective of the behaviour of the profile function all geometries in the class are complete.

  18. Characterization and genomic analysis of a plaque purified strain of cyanophage PP.

    Science.gov (United States)

    Zhou, Yiran; Lin, Juan; Li, Na; Hu, Zhihong; Deng, Fei

    2013-10-01

    Cyanophages are ubiquitous and essential components of the aquatic environment and play an important role in the termination of algal blooms. As such, they have attracted widespread interest. PP was the first isolated cyanophage in China, which infects Plectonema boryanum and Phormidium foveolarum. In this study, this cyanophage was purified three times by a double-agar overlay plaque assay and characterized. Its genome was extracted, totally sequenced and analyzed. Electron microscopy revealed a particle with an icosahedral head connected to a short stubby tail. Bioassays showed that PP was quite virulent. The genome of PP is a 42,480 base pair (bp), linear, double-stranded DNA molecule with 222 bp terminal repeats. It has high similarity with the known Pf-WMP3 sequence. It contains 41 open reading frames (ORFs), 17 of which were annotated. Intriguingly, the genome can be divided into two completely different parts, which differ both in orientation and function.

  19. Tensor Correlations Measured in 3He(e,e'pp)n

    CERN Document Server

    Baghdasaryan, H; Laget, J M; Adhikari, K P; Aghasyan, M; Amarian, M; Anghinolfi, M; Avakian, H; Ball, J; Battaglieri, M; Bedlinskiy, I; Berman, B L; Biselli, A S; Bookwalter, C; Briscoe, W J; Brooks, W K; B?ultmann, S; Burkert, V D; Carman, D S; Crede, V; D'Angelo, A; Daniel, A; Dashyan, N; DeVita, R; DeSanctis, E; Deur, A; Dey, B; Dickson, R; Djalali, C; Dodge, G E; Doughty, D; Dupre, R; Egiyan, H; Alaoui, A El; Fassi, L El; Eugenio, P; Fegan, S; Gabrielyan, M Y; Gilfoyle, G P; Giovanetti, K L; Gohn, W; Gothe, R W; Griffioen, K A; Guidal, M; Guo, L; Gyurjyan, V; Hakobyan, H; Hanretty, C; Hyde, C E; Hicks, K; Holtrop, M; Ilieva, Y; Ireland, D G; Joo, K; Keller, D; Khandaker, M; Khetarpal, P; Kim, A; Kim, W; Klein, A; Klein, F J; Konczykowski, P; Kubarovsky, V; Kuhn, S E; Kuleshov, S V; Kuznetsov, V; Kvaltine, N D; Livingston, K; Lu, H Y; MacGregor, I J D; Markov, N; Mayer, M; McAndrew, J; McKinnon, B; Meyer, C A; Mikhailov, K; Mokeev, V; Moreno, B; Moriya, K; Morrison, B; Moutarde, H; Munevar, E; Nadel-Turonski, P; Nepali, C; Niccolai, S; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Paremuzyan, R; Park, K; Park, S; Pasyuk, E; Pereira, S Anefalos; Pisano, S; Pogorelko, O; Pozdniakov, S; Price, J W; Procureur, S; Protopopescu, D; Ricco, G; Ripani, M; Rosner, G; Rossi, P; Sabati?e, F; Salgado, C; Schumacher, R A; Seraydaryan, H; Smith, G D; Sober, D I; Sokhan, D; Stepanyan, S S; Stepanyan, S; Stoler, P; Strauch, S; Taiuti, M; Tang, W; Taylor, C E; Tedeschi, D J; Ungaro, M; Vineyard, M F; Voutier, E; Watts, D P; Weygand, D P; Wood, M H; Zhao, B; Zhao, Z W

    2010-01-01

    We have measured the 3He(e,e'pp)n reaction at an incident energy of 4.7 GeV over a wide kinematic range. We identified spectator correlated pp and pn nucleon pairs using kinematic cuts and measured their relative and total momentum distributions. This is the first measurement of the ratio of pp to pn pairs as a function of pair total momentum, $p_{tot}$. For pair relative momenta between 0.3 and 0.5 GeV/c, the ratio is very small at low $p_{tot}$ and rises to approximately 0.5 at large $p_{tot}$. This shows the dominance of tensor over central correlations at this relative momentum.

  20. Tensor Correlations Measured in 3He(e,e'pp)n

    Energy Technology Data Exchange (ETDEWEB)

    Baghdasaryan, H; Weinstein, L B; Adhikari, K P; Aghasyan, K P; Amarian, M; Anghinolfi, M; Avakian, H; Ball, J; Battaglieri, M; Bedlinskiy, I; Berman, B L; Biselli, A S; Bookwalter, C; Briscoe, W J; Brooks, W K; Boltmann, S; Burkert, V D; Carman, D S; Crede, V; D& #x27; Angelo, A; Daniel, A; Dashyan, N; DeVita, R; DeSanctis, E; Deur, A; Dey, B; Dickson, R; Djalali, C; Dodge, G E; Doughty, D; Dupre, R; Egiyan, H; El Alaoui, A; El Fassi, L; Eugenio, P; Fegan, S; Gabrielyan, M Y; Gilfoyle, G P; Giovanetti, K L; Gohn, W; Gothe, R W; Griffioen, K A; Guidal, M; Guo, L; Gyurjyan, V; Hakobyan, H; Hanretty, C; Hyde, C E; Hicks, K; Holtrop, M; Ilieva, Y; Ireland, D G; Joo, K; Keller, D; Khandaker, M; Khetarpal, P; Kim, A; Kim, W; Klein, A; Klein, F J; Konczykowski, P; Kubarovsky, V; Kuhn, S E; Kuleshov, S V; Kuznetsov, V; Kvaltine, N D; Livingston, K; Lu, H Y; MacGregor, I.J.D.; Markov, N; Mayer, M; McAndrew, J; McKinnon, B; Meyer, C A; Mikhailov, K; Mokeev, V; Moreno, B; Moriya, K; Morrison, B; Moutarde, H; Munevar, E; Nadel-Turonski, P; Nepali, C; Niccolai, S; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Paremuzyan, R; Park, K; Park, S; Pasyuk, E; Anefalos Pereira, S; Pisano, S; Pogorelko, O; Pozdniakov, S; Price, J W; Procureur, S; Protopopescu, D; Ricco, G; Ripani, M; Rosner, G; Rossi, P; Sabatie, F; Salgado, C; Schumacher, R A; Seraydaryan, H; Smith, G D; Sober, D I; Sokhan, D; Stepanyan, S S; Stepanyan, S; Stoler, P; Strauch, S; Taiuti, M; Tang, W; Taylor, C E; Tedeschi, D J; Ungaro, M; Vineyard, M F; Voutier, E; Watts, D P; Weygand, D P; Wood, M H; Zhao, B; Zhao, Z W

    2010-11-01

    We have measured the 3He(e,e'pp)n reaction at an incident energy of 4.7 GeV over a wide kinematic range. We identified spectator correlated pp and pn nucleon pairs by using kinematic cuts and measured their relative and total momentum distributions. This is the first measurement of the ratio of pp to pn pairs as a function of pair total momentum ptot. For pair relative momenta between 0.3 and 0.5 GeV/c, the ratio is very small at low ptot and rises to approximately 0.5 at large ptot. This shows the dominance of tensor over central correlations at this relative momentum.

  1. One pion production in pp collisions at 162 GeV/c

    CERN Document Server

    Gnat, Y; Benary, O; Dagan, S; Grunhaus, Jacob; Levy, A; Oren, Y; Schlesinger, J

    1973-01-01

    A study of pp interactions at an incident momentum of 16.2 GeV/c leading to two-prong non-strange final states was carried out in an exposure of the 2m CERN hydrogen bubble chamber. The c.m. angle and momentum distributions for the outgoing particles in the final states pn pi /sup +/ and pp pi /sup 0/ are presented and discussed. These final states were analysed in terms of quasi two-body final states -N (N pi ), with the pion-nucleon system in an I=/sup 1///sub 2/ or I= /sup 3///sub 2/ state. A determination of these two isospin amplitudes and their interference terms is then carried out. The reaction pp to pn pi /sup +/ is found to be well described by a Reggeized exchange model, as well as by a double Regge-exchange model. (14 refs).

  2. Observables for possible QGP signatures in central pp collisions arXiv

    CERN Document Server

    Mangano, Michelangelo L.

    Proton-proton (pp) data show collective effects, such as long-range azimuthal correlations and strangeness enhancement, which are similar to phenomenology observed in heavy ion collisions. Using simulations with and without explicit existing models of collective effects, we explore new ways to probe pp collisions at high multiplicity, in order to suggest measurements that could help identify the similarities and differences between large- and small-scale collective effects. In particular, we focus on the properties of jets produced in ultra-central pp collisions in association with a Z boson. We consider observables such as jet energy loss and jet shapes, which could point to the possible existence of an underlying quark-gluon plasma, or other new dynamical effects related to the presence of large hadronic densities.

  3. Scattered antiproton polarization in pp elastic scattering at 220 MeV in bubble chamber

    CERN Document Server

    Ohsugi, T

    1973-01-01

    The polarization of antiproton scattering in pp elastic collision has been measured in the four intervals of the CM scattering angle theta /sup */ less than 90 degrees by means of double scattering in a bubble chamber. The analysis has been performed on the basis of 999 double elastic events which have been found in about 100K pictures of the 81- cm Saclay hydrogen bubble chamber exposed to a 0.7 GeV/c antiproton beam from the CERN PS. The obtained values of polarization show the maximum value 0.52+or-0.19 at theta /sup */=56 degrees . The polarization for pp scattering seems to be larger than that for pp scattering. The results are also compared with the potential model by Bryan and Phillips (1968) and with the modified diffraction model by Frahn and Venter (1964). Possible systematic errors in the present experiment are discussed in detail. (17 refs).

  4. DSP-PP precursor protein cleavage by tolloid-related-1 protein and by bone morphogenetic protein-1.

    Directory of Open Access Journals (Sweden)

    Helena H Ritchie

    Full Text Available Dentin sialoprotein (DSP and phosphophoryn (PP, acidic proteins critical to dentin mineralization, are translated from a single transcript as a DSP-PP precursor that undergoes specific proteolytic processing to generate DSP and PP. The cleavage mechanism continues to be controversial, in part because of the difficulty of obtaining DSP-PP from mammalian cells and dentin matrix. We have infected Sf9 cells with a recombinant baculovirus to produce large amounts of secreted DSP-PP(240, a variant form of rat DSP-PP. Mass spectrometric analysis shows that DSP-PP(240 secreted by Sf9 cells undergoes specific cleavage at the site predicted from the N-terminal sequence of PP extracted from dentin matrix: SMQG(447↓D(448DPN. DSP-PP(240 is cleaved after secretion by a zinc-dependent activity secreted by Sf9 cells, generating DSP(430 and PP(240 products that are stable in the medium. DSP-PP processing activity is constitutively secreted by Sf9 cells, but secretion is diminished 3 days after infection. Using primers corresponding to the highly conserved catalytic domain of Drosophila melanogaster tolloid (a mammalian BMP1 homolog, we isolated a partial cDNA for a Spodopotera frugiperda tolloid-related-1 protein (TLR1 that is 78% identical to Drosophila TLR1 but only 65% identical to Drosophila tolloid. Tlr1 mRNA decreased rapidly in Sf9 cells after baculovirus infection and was undetectable 4d after infection, paralleling the observed decrease in secretion of the DSP-PP(240 processing activity after infection. Human BMP1 is more similar to Sf9 and Drosophila TLR1 than to tolloid, and Sf9 TLR1 is more similar to BMP1 than to other mammalian homologs. Recombinant human BMP1 correctly processed baculovirus-expressed DSP-PP(240 in a dose-dependent manner. Together, these data suggest that the physiologically accurate cleavage of mammalian DSP-PP(240 in the Sf9 cell system represents the action of a conserved processing enzyme and support the proposed role of BMP

  5. DSP-PP precursor protein cleavage by tolloid-related-1 protein and by bone morphogenetic protein-1.

    Science.gov (United States)

    Ritchie, Helena H; Yee, Colin T; Tang, Xu-Na; Dong, Zhihong; Fuller, Robert S

    2012-01-01

    Dentin sialoprotein (DSP) and phosphophoryn (PP), acidic proteins critical to dentin mineralization, are translated from a single transcript as a DSP-PP precursor that undergoes specific proteolytic processing to generate DSP and PP. The cleavage mechanism continues to be controversial, in part because of the difficulty of obtaining DSP-PP from mammalian cells and dentin matrix. We have infected Sf9 cells with a recombinant baculovirus to produce large amounts of secreted DSP-PP(240), a variant form of rat DSP-PP. Mass spectrometric analysis shows that DSP-PP(240) secreted by Sf9 cells undergoes specific cleavage at the site predicted from the N-terminal sequence of PP extracted from dentin matrix: SMQG(447)↓D(448)DPN. DSP-PP(240) is cleaved after secretion by a zinc-dependent activity secreted by Sf9 cells, generating DSP(430) and PP(240) products that are stable in the medium. DSP-PP processing activity is constitutively secreted by Sf9 cells, but secretion is diminished 3 days after infection. Using primers corresponding to the highly conserved catalytic domain of Drosophila melanogaster tolloid (a mammalian BMP1 homolog), we isolated a partial cDNA for a Spodopotera frugiperda tolloid-related-1 protein (TLR1) that is 78% identical to Drosophila TLR1 but only 65% identical to Drosophila tolloid. Tlr1 mRNA decreased rapidly in Sf9 cells after baculovirus infection and was undetectable 4d after infection, paralleling the observed decrease in secretion of the DSP-PP(240) processing activity after infection. Human BMP1 is more similar to Sf9 and Drosophila TLR1 than to tolloid, and Sf9 TLR1 is more similar to BMP1 than to other mammalian homologs. Recombinant human BMP1 correctly processed baculovirus-expressed DSP-PP(240) in a dose-dependent manner. Together, these data suggest that the physiologically accurate cleavage of mammalian DSP-PP(240) in the Sf9 cell system represents the action of a conserved processing enzyme and support the proposed role of BMP1 in

  6. Propofol inhibits high glucose-induced PP2A expression in human umbilical vein endothelial cells.

    Science.gov (United States)

    Wu, Qichao; Zhao, Yanjun; Duan, Wenming; Liu, Yi; Chen, Xiangyuan; Zhu, Minmin

    2017-04-01

    Perioperative hyperglycemia is a common clinical metabolic disorder. Hyperglycemia could induce endothelial apoptosis, dysfunction and inflammation, resulting in endothelial injury. Propofol is a widely used anesthetic drug in clinical settings. Our previous studies indicated that propofol, via inhibiting high glucose-induced phosphatase A2 (PP2A) expression, attenuated high glucose-induced reactive oxygen species (ROS) accumulation, thus improving endothelial apoptosis, dysfunction and inflammation. However, the mechanisms by which propofol attenuated high glucose-induced PP2A expression is still obscure. In the present study, we examined how propofol attenuates high glucose-induced endothelial PP2A expression. Compared with 5mM glucose treatment, 15mM glucose up-regulated expression and activity of PP2A, increased cAMP response element binding protein (CREB), Ca(2+)-calmodulin dependent kinase II (CaMK II) phosphorylation and Ca(2+) accumulation. More importantly, propofol decreased PP2A expression and activity, attenuated CREB, CaMK II phosphorylation and Ca(2+) accumulation in a concentration-dependent manner. Moreover, we demonstrated that the effect of propofol was similar to that of MK801, an inhibitor of NMDA receptor. In contrast, rapastinel, an activator of NMDA receptor, antagonized the effect of propofol. Also, the effect of KN93, an inhibitor of CaMK II, was similar to that of propofol, except KN93 had no effect on 15mM glucose-mediated Ca(2+) accumulation. Our data indicated that propofol, via inhibiting NMDA receptor, attenuated 15mM glucose-induced Ca(2+) accumulation, CaMK II and CREB phosphorylation, thus inhibiting PP2A expression and improving 15mM glucose-induced endothelial dysfunction and inflammation. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Quantitative evaluation of iPP nucleation in the presence of carbon fibres: induction time approach

    Directory of Open Access Journals (Sweden)

    ANITA GROZDANOV

    2002-12-01

    Full Text Available Crystallization and nucleation behavior in model composites based on iPP and differently sized carbon fibres have been analyzed in this work. The investigations were performed in the isothermal regime (120–127°C using PLM and DSC. The results were analyzed by applying the Avrami and Muchova-Lednicky methods. It was shown that the carbon fibre surface acts as a nucleating agent during the crystallization of the iPP matrix. The highest effect was obtained with the fibres of PP-compatible size (C-T related to unsized carbon fibres (C-U. The induction time,ti, and half-time of crystallization decreased with increasing carbon fibre content. The energy effect on the thickness of the critical nucleus decreased in the presence of C-fibres, a fact confirmed by a decrease in the nucleation parameter Q and the difference energy parameter Ds(Q decreased from – 4.96 for iPP to –21.32 for C/iPP model composites, and Ds decreased from 6.14×10-7 J/cm2for iPP to 1.63×10-7 J/cm2for model composites. The results of the model composites and their comparison with published data confirmed that the Muchova-Lednicky method could be successfully applied for the quantitative evaluation of the nucleation parameters not only in the temperature range previously suggested (130 – 138°C, but also at lower crystallization temperatures (Tc = 121–127°C.

  8. PP/APLP2 Family of Kunitz Serine Proteinase Inhibitors Regulate Cerebral Thrombosis

    Science.gov (United States)

    Xu, Feng; Previti, Mary Lou; Nieman, Marvin T.; Davis, Judianne; Schmaier, Alvin H.; Van Nostrand, William E.

    2009-01-01

    The amyloid β-protein precursor (AβPP) is best recognized as the precursor to the Aβ peptide that accumulates in the brains of patients with Alzheimer’s disease, but less is known about its physiological functions. Isoforms of AβPP that contain a Kunitz-type serine proteinase inhibitor (KPI) domain are expressed in brain and, outside the CNS, in circulating blood platelets. Recently, we showed that KPI-containing forms of AβPP regulates cerebral thrombosis in vivo (Xu et al., 2005 Proc. Natl. Acad. Sci. USA 102:18135–18140; Xu et al. 2007 Stroke 38:2598–2601). Amyloid precursor like protein-2 (APLP2), a closely related homolog to AβPP, also possesses a highly conserved KPI domain. Virtually nothing is known of its function. Here we show that APLP2 also regulates cerebral thrombosis risk. Recombinant purified KPI domains of AβPP and APLP2 both inhibit the plasma clotting in vitro. In a carotid artery thrombosis model both AβPP−/− and APLP2−/− mice exhibit similar significantly shorter times to vessel occlusion compared with wild-type mice indicating a pro-thrombotic phenotype. Similarly, in an experimental model of intracerebral hemorrhage both AβPP−/− and APLP2−/− mice produce significantly smaller hematomas with reduced brain hemoglobin content compared with wild-type mice. Together, these results indicate that AβPP and APLP2 share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury. PMID:19403832

  9. Serine / threonine protein phosphatase 5 (PP5 participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling

    Directory of Open Access Journals (Sweden)

    Bueno Manuel

    2001-05-01

    Full Text Available Abstract Background In most cells glucocorticoid receptors (GR reside predominately in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription of GR-responsive genes. Serine/threonine protein phosphatase type 5 (PP5 associates with the GR-heat-shock protein-90 complex, and the suppression of PP5 expression with ISIS 15534 stimulates the activity of GR-responsive reporter plasmids, without affecting the binding of hormone to the GR. Results To further characterize the mechanism by which PP5 affects GR-induced gene expression, we employed immunofluorescence microscopy to track the movement of a GR-green fluorescent fusion protein (GR-GFP that retained hormone binding, nuclear translocation activity and specific DNA binding activity, but is incapable of transactivation. In the absence of glucocorticoids, GR-GFP localized mainly in the cytoplasm. Treatment with dexamethasone results in the efficient translocation of GR-GFPs into the nucleus. The nuclear accumulation of GR-GFP, without the addition of glucocorticoids, was also observed when the expression of PP5 was suppressed by treatment with ISIS 15534. In contrast, ISIS 15534 treatment had no apparent effect on calcium induced nuclear translocation of NFAT-GFP. Conclusion These studies suggest that PP5 participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling, and that the GR-induced transcriptional activity observed when the expression of PP5 is suppressed by treatment with ISIS 15534 results from the nuclear accumulation of GR in a form that is capable of binding DNA yet still requires agonist to elicit maximal transcriptional activation.

  10. Role of ppGpp in rpoS stationary-phase regulation in Escherichia coli.

    Science.gov (United States)

    Hirsch, Matthew; Elliott, Thomas

    2002-09-01

    The bacterial sigma factor RpoS is strongly induced under a variety of stress conditions and during growth into stationary phase. Here, we used rpoS-lac fusions in Escherichia coli to investigate control acting at the level of RpoS synthesis, which is especially evident when cells approach stationary phase in rich medium. Previous work has shown that the small molecule ppGpp is required for normal levels of RpoS in stationary phase. Despite the attraction of a model in which the ppGpp level controls stationary-phase induction of RpoS, careful measurement of rpoS-lac expression in a mutant lacking ppGpp showed similar effects during both exponential growth and stationary phase; the main effect of ppGpp was on basal expression. In addition, a modest regulatory defect was associated with the mutant lacking ppGpp, delaying the time at which full expression was achieved by 2 to 3 h. Deletion analysis showed that the defect in basal expression was distributed over several sequence elements, while the regulatory defect mapped to the region upstream of the rpoS ribosome-binding site (RBS) that contains a cis-acting antisense element. A number of other genes that have been suggested as regulators of rpoS were tested, including dksA, dsrA, barA, ppkx, and hfq. With the exception of the dksA mutant, which had a modest defect in Luria-Bertani medium, none of these mutants was defective for rpoS stationary-phase induction. Even a short rpoS segment starting at 24 nucleotides upstream of the AUG initiation codon was sufficient to confer substantial stationary-phase regulation, which was mainly posttranscriptional. The effect of RBS-proximal sequence was independent of all known trans-acting factors, including ppGpp.

  11. Role of ppGpp in Pseudomonas aeruginosa acute pulmonary infection and virulence regulation.

    Science.gov (United States)

    Xu, Xiaohui; Yu, Hua; Zhang, Di; Xiong, Junzhi; Qiu, Jing; Xin, Rong; He, Xiaomei; Sheng, Halei; Cai, Wenqiang; Jiang, Lu; Zhang, Kebin; Hu, Xiaomei

    2016-11-01

    During infection, bacteria might generate adaptive responses to facilitate their survival and colonization in the host environment. The alarmone guanosine 5'-triphosphate-3'-diphosphate (ppGpp), the levels of which are regulated by the RelA and SpoT enzymes, plays a critical role in mediating bacterial adaptive responses and virulence. However, the mechanism by which ppGpp regulates virulence-associated traits in Pseudomonas aeruginosa is poorly understood. To investigate the regulatory role of ppGpp, the ppGpp-deficient strain ΔRS (relA and spoT gene double mutant) and the complemented strain ΔRS(++) (complemented with relA and spoT genes) were constructed. Herein, we reported that the ΔRS strain showed decreased cytotoxicity towards A549 human alveolar adenocarcinoma cell lines and led to reduced mortality, lung edema and inflammatory cell infiltration in a mouse model of acute pneumonia compared to wild-type PAO1 and the complemented strain ΔRS(++). Subsequent analyses demonstrated that the ΔRS strain displayed reduced T3SS expression, decreased levels of elastase activity, pyocyanin, pyoverdin and alginate, and inhibited swarming and biofilm formation compared to PAO1 and the complemented strain ΔRS(++). In addition, the results demonstrate that ppGpp-mediated regulation of T3SS, virulence factor production, and swarming occurs in a quinolone quorum-sensing system-dependent manner. Taken together, these results suggest that ppGpp is required for virulence regulation in P. aeruginosa, providing new clues for the development of interference strategies against bacterial infection.

  12. DksA and (p)ppGpp have unique and overlapping contributions to Haemophilus ducreyi pathogenesis in humans.

    Science.gov (United States)

    Holley, Concerta L; Zhang, Xinjun; Fortney, Kate R; Ellinger, Sheila; Johnson, Paula; Baker, Beth; Liu, Yunlong; Janowicz, Diane M; Katz, Barry P; Munson, Robert S; Spinola, Stanley M

    2015-08-01

    The (p)ppGpp-mediated stringent response is important for bacterial survival in nutrient limiting conditions. For maximal effect, (p)ppGpp interacts with the cofactor DksA, which stabilizes (p)ppGpp's interaction with RNA polymerase. We previously demonstrated that (p)ppGpp was required for the virulence of Haemophilus ducreyi in humans. Here, we constructed an H. ducreyi dksA mutant and showed it was also partially attenuated for pustule formation in human volunteers. To understand the roles of (p)ppGpp and DksA in gene regulation in H. ducreyi, we defined genes potentially altered by (p)ppGpp and DksA deficiency using transcriptome sequencing (RNA-seq). In bacteria collected at stationary phase, lack of (p)ppGpp and DksA altered expression of 28% and 17% of H. ducreyi open reading frames, respectively, including genes involved in transcription, translation, and metabolism. There was significant overlap in genes differentially expressed in the (p)ppGpp mutant relative to the dksA mutant. Loss of (p)ppGpp or DksA resulted in the dysregulation of several known virulence determinants. Deletion of dksA downregulated lspB and rendered the organism less resistant to phagocytosis and increased its sensitivity to oxidative stress. Both mutants had reduced ability to attach to human foreskin fibroblasts; the defect correlated with reduced expression of the Flp adhesin proteins in the (p)ppGpp mutant but not in the dksA mutant, suggesting that DksA regulates the expression of an unknown cofactor(s) required for Flp-mediated adherence. We conclude that both (p)ppGpp and DksA serve as major regulators of H. ducreyi gene expression in stationary phase and have both overlapping and unique contributions to pathogenesis.

  13. A novel tetratricopeptide repeat (TPR containing PP5 serine/threonine protein phosphatase in the malaria parasite, Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Adams Brian

    2001-11-01

    Full Text Available Abstract Background The malarial parasite, Plasmodium falciparum (Pf, is responsible for nearly 2 million deaths worldwide. However, the mechanisms of cellular signaling in the parasite remain largely unknown. Recent discovery of a few protein kinases and phosphatases point to a thriving reversible phosphorylation system in the parasite, although their function and regulation need to be determined. Results We provide biochemical and sequence evidence for a protein serine/threonine phosphatase type PP5 in Plasmodium falciparum, and named it PfPP5. The 594-amino acid polypeptide was encoded by a 1785 nucleotide long intronless gene in the parasite. The recombinant protein, expressed in bacteria, was indistinguishable from native PfPP5. Sequencing comparison indicated that the extra-long N-terminus of PfPP5 outside the catalytic core contained four tetratricopeptide repeats (TPRs, compared to three such repeats in other PP5 phosphatases. The PfPP5 N-terminus was required for stimulation of the phosphatase activity by polyunsaturated fatty acids. Co-immunoprecipitation demonstrated an interaction between native PfPP5 and Pf heat shock protein 90 (hsp90. PfPP5 was expressed in all the asexual erythrocytic stages of the parasite, and was moderately sensitive to okadaic acid. Conclusions This is the first example of a TPR-domain protein in the Apicomplexa family of parasites. Since TPR domains play important roles in protein-protein interaction, especially relevant to the regulation of PP5 phosphatases, PfPP5 is destined to have a definitive role in parasitic growth and signaling pathways. This is exemplified by the interaction between PfPP5 and the cognate chaperone hsp90.

  14. Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions.

    Science.gov (United States)

    Geiger, Tobias; Kästle, Benjamin; Gratani, Fabio Lino; Goerke, Christiane; Wolz, Christiane

    2014-02-01

    The stringent response is a conserved global regulatory mechanism that is related to the synthesis of (p)ppGpp nucleotides. Gram-positive bacteria, such as Staphylococcus aureus, possess three (p)ppGpp synthases: the bifunctional RSH (RelA/SpoT homolog) protein, which consists of a (p)ppGpp synthase and a (p)ppGpp hydrolase domain, and two truncated (p)ppGpp synthases, designated RelP and RelQ. Here, we characterized these two small (p)ppGpp synthases. Biochemical analyses of purified proteins and in vivo studies revealed a stronger synthetic activity for RelP than for RelQ. However, both enzymes prefer GDP over GTP as the pyrophosphate recipient to synthesize ppGpp. Each of the enzymes was shown to be responsible for the essentiality of the (p)ppGpp hydrolase domain of the RSH protein. The staphylococcal RSH-hydrolase is an efficient enzyme that prevents the toxic accumulation of (p)ppGpp. Expression of (p)ppGpp synthases in a hydrolase-negative background leads not only to growth arrest but also to cell death. Transcriptional analyses showed that relP and relQ are strongly induced upon vancomycin and ampicillin treatments. Accordingly, mutants lacking relP and relQ showed a significantly reduced survival rate upon treatments with cell wall-active antibiotics. Thus, RelP and RelQ are active (p)ppGpp synthases in S. aureus that are induced under cell envelope stress to mediate tolerance against these conditions.

  15. Role of (p)ppGpp in biofilm formation and expression of filamentous structures in Bordetella pertussis.

    Science.gov (United States)

    Sugisaki, Kentaro; Hanawa, Tomoko; Yonezawa, Hideo; Osaki, Takako; Fukutomi, Toshiyuki; Kawakami, Hayato; Yamamoto, Tomoko; Kamiya, Shigeru

    2013-07-01

    Bordetella pertussis, the causative agent of whooping cough, is highly adapted to cause human infection. The production of virulence factors, such as adhesins and toxins, is just part of an array of mechanisms by which B. pertussis causes infection. The stringent response is a global bacterial response to nutritional limitation that is mediated by the accumulation of cellular ppGpp and pppGpp [termed together as (p)ppGpp]. Here, we demonstrate that production of (p)ppGpp was controlled by RelA and SpoT proteins in B. pertussis, and that mutation-induced loss of both proteins together caused deficiencies in (p)ppGpp production. The (p)ppGpp-deficient mutants also exhibited defects in growth regulation, decreases in viability under nutritionally limited conditions, increases in susceptibility to oxidative stress and defects in biofilm formation. Analysis of the secreted proteins and the respective transcripts showed that lack of (p)ppGpp led to decreased expression of fim3 and bsp22, which encode a fimbrial subunit and the self-polymerizing type III secretion system tip protein, respectively. Moreover, electron microscopic analysis also indicated that (p)ppGpp regulated the formation of filamentous structures. Most virulence genes - including fim3 and bsp22 - were expressed in the Bvg(+) phase during which the BvgAS two-component system was activated. Although fim3 and bsp22 were downregulated in a (p)ppGpp-deficient mutant, normal expression of fhaB, cyaA and ptxA persisted. Lack of coherence between virulence gene expression and (p)ppGpp production indicated that (p)ppGpp did not modulate the Bvg phase. Taken together, our data indicate that (p)ppGpp may govern an as-yet-unrecognized system that influences B. pertussis pathogenicity.

  16. Heavy-flavour production in pp collisions and correlations in pp and p-Pb collisions measured with ALICE at the LHC

    CERN Document Server

    INSPIRE-00246108

    2016-01-01

    Thanks to its excellent tracking and particle identification performance, the ALICE detector is capable of measuring D mesons at central rapidity via their hadronic decay channels down to very low transverse momentum. We show an extension of the prompt ${\\rm D}^0$ $p_{\\rm T}$-differential cross section measurement down to zero transverse momentum, which allows us to determine the $p_{\\rm T}$-integrated charm production cross section at central rapidity in pp collisions at $\\sqrt{s}$ = 7 TeV. We also present measurements of azimuthal correlations of prompt ${\\rm D}^0$, ${\\rm D}^+$ and ${\\rm D}^{*+}$ mesons with charged hadrons in pp collisions at $\\sqrt{s}$ = 7 TeV and p-Pb collisions at $\\sqrt{s_{\\scriptscriptstyle \\rm NN}}$ = 5.02 TeV and compare the results with expectations from models.

  17. Precision measurements of the pp\\to \\pi^+pn and pp\\to \\pi^+d reactions: importance of long-range and tensor force effects

    CERN Document Server

    Budzanowski, A; Hawranek, P; Jahn, R; Jha, V; Kilian, K; Kirillov, Da; Kirillov, Di; Kliczewski, S; Kolev, D; Kravcikova, M; Lesiak, M; Lieb, J; Machner, H; Magiera, A; Maier, R; Martinská, G; Nedev, S; Niskanen, J A; Piskunov, N; Protic, D; Ritman, 6 J; Von Rossen, P; Roy, B J; Sitnik, I; Siudak, R; Stein, H J; Tsenov, R; Urbán, J; Vankova, 2 G; Wilkin, C

    2009-01-01

    Inclusive measurements of pion production in proton--proton collisions in the forward direction were undertaken at 400 and 600 MeV at COSY using the Big Karl spectrograph. The high resolution in the $\\pi^+$ momentum ensured that there was an unambiguous separation of the $pp\\to {\\pi}^+d/\\pi^+pn$ channels. Using these and earlier data, the ratio of the production cross sections could be followed through the $\\Delta$ region and compared with the predictions of final state interaction theory. Deviations are strongly influenced by long-range terms in the production operator and the tensor force in the final $pn$ system. These have been investigated in a realistic $pp\\to\\pi^+d/\\pi^+pn$ calculation that includes $S \\rightleftharpoons D$ channel coupling between the final nucleons. A semi-quantitative understanding of the observed effects is achieved.

  18. Effects of the high doses of irradiation on the mechanical properties of PS/PP blends

    Energy Technology Data Exchange (ETDEWEB)

    Albano, C. E-mail: calbano@ivic.vealbanoc@camelot.rect.ucv.ve; Reyes, J.; Ichazo, M.N.; Gonzalez, J.; Rodriguez, M

    2003-08-01

    The effect of gamma irradiation on the tensile behavior of the polystyrene/polypropylene (PS/PP) blend (80/20) without and with styrene-butadiene-styrene (SBS) points to a deterioration of the mechanical properties of the blends due to the scission and crosslinking reactions resulting from irradiation. A kinetic analysis of the behavior of mixtures of PS/PP with SBS shows that a radiation dose between 70 and 400 kGy, the dominant process is the chain scission meanwhile at higher doses appear a competitive mechanisms (chain scission and crosslinking) with a sensitive decrease of the properties in the break point.

  19. Role of PET in improving wear properties of PP in dry sliding condition

    Indian Academy of Sciences (India)

    Somit Neogi; S A R Hashmi; Navin Chand

    2003-10-01

    The sliding wear of isotactic polypropylene (PP), polyethylene terephthalate (PET) and their blends was evaluated as a function of applied pressure and composition against a stainless steel counter face in dry condition. Wear rate decreases with the addition of PET in the blend. The wear was observed in two stages, the moderate wear and high wear while increasing the applied pressure on test samples. The addition of PET in PP helps in increasing the limit of moderate wear towards the high-pressure side. Microstructure and worn surfaces of samples were observed by scanning electron microscope. The wear phenomenon has been discussed based on wear losses and worn surfaces.

  20. Identified Particle Production in d+Au and p+p collisions at RHIC

    CERN Document Server

    Hongyan Yang

    2008-01-01

    The BRAHMS experiment at RHIC has measured the transverse momentum spectra of charged pions, kaons and (anti-)protons over a wide range of rapidity in d+Au and p+p collisions at $\\sqrt{s_{NN}}=200 $GeV. The nuclear modification factor $R_{dAu}$ at forward rapidities shows a clear suppression for $\\pi^{+}$. The measured net-proton yields in p+p collisions are compared to PYTHIA and HIJING/B and seem to be better described by the latter.

  1. Identified particle production in p+p and d+Au collisions at RHIC

    Science.gov (United States)

    Yang, Hongyan; BRAHMS Collaboration

    2007-08-01

    The BRAHMS experiment at RHIC has measured the transverse momentum spectra of charged pions, kaons and (anti-)protons over a wide range of rapidity in d+Au and p+p collisions at \\sqrt{s_NN}=200 GeV. The nuclear modification factor RdAu at forward rapidity shows a clear suppression for π+. The measured net-proton yields in p+p collisions are compared to PYTHIA and HIJING/B and seem to be better described by the latter.

  2. Investigation of the Λ(1405) line shape observed in pp collisions

    Science.gov (United States)

    Siebenson, J.; Fabbietti, L.

    2013-11-01

    In this work we investigate different possible interpretations of the Λ(1405) signal associated with the production of the Λ(1405) in p+p reactions at 3.5 GeV beam kinetic energy measured by the HADES collaboration. We study the influence of interference effects between the Λ(1405) resonance and the nonresonant background. The two poles nature of the Λ(1405), which is supported by most of the theoretical models, is also discussed with emphasis on the relative contributions of the two complex poles to the formation of the resonance in p+p reactions.

  3. Two-Nucleon Momentum Distributions Measured in 3He(e,e'pp)n

    CERN Document Server

    Niyazov, R A; Weinstein, L B; Adams, G; Ambrozewicz, P; Anciant, E; Anghinolfi, M; Asavapibhop, B; Audit, G; Auger, T; Avakian, H; Bagdasaryan, H; Ball, J P; Barrow, S; Battaglieri, M; Beard, K; Bektasoglu, M; Bellis, M; Benmouna, N; Berman, Barry L; Bianchi, N; Biselli, A S; Boiarinov, S; Bonner, B E; Bouchigny, S; Bradford, R; Branford, D; Brooks, W K; Burkert, V D; Butuceanu, C; Calarco, J R; Carman, D S; Carnahan, B; Cetina, C; Chen, S; Ciciani, L; Cole, P L; Coleman, A; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J P; De Sanctis, E; De Vita, R; Degtyarenko, P V; Denizli, H; Dennis, L; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Doughty, D C; Dragovitsch, P; Dugger, M; Dytman, S; Dzyubak, O P; Eckhause, M; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Empl, A; Eugenio, P; Fatemi, R; Feuerbach, R J; Ficenec, J; Forest, T A; Funsten, H; Gavalian, G; Gilfoyle, G P; Giovanetti, K L; Girard, P; Gordon, C I O; Griffioen, K; Guidal, M; Guillo, M R; Guo, L; Gyurjyan, V; Hadjidakis, C; Hakobyan, R S; Hardie, J; Heddle, D; Hersman, F W; Hicks, K; Holtrop, M; Hu, J; Hyde-Wright, C E; Ilieva, Y; Ito, M M; Jenkins, D; Joo, K; Jüngst, H G; Kelley, J H; Khandaker, M; Kim, D H; Kim, K Y; Kim, K; Kim, M S; Kim, W; Klein, A; Klein, F J; Klimenko, A V; Klusman, M; Kossov, M; Kramer, L H; Kuang, Y; Kuhn, S E; Kühn, J; Lachniet, J; Laget, J M; Langheinrich, J; Lawrence, D; Ji Li; Lukashin, K; Manak, J J; Marchand, C; McAleer, S; McNabb, J W C; Mecking, B A; Mehrabyan, S S; Melone, J J; Mestayer, M D; Meyer, C A; Mikhailov, K; Mirazita, M; Miskimen, R; Morand, L; Morrow, S A; Muccifora, V; Müller, J; Mutchler, G S; Napolitano, J; Nasseripour, R; Nelson, S O; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Nozar, M; O'Rielly, G V; Osipenko, M; Park, K; Pasyuk, E A; Peterson, G; Philips, S A; Pivnyuk, N; Pocanic, D; Pogorelko, O I; Polli, E; Pozdniakov, S; Preedom, B M; Price, J W; Prok, Y; Protopopescu, D; Qin, L M; Raue, B A; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Ronchetti, F; Rossi, P; Rowntree, D; Rubin, P D; Sabatie, F; Sabourov, K; Salgado, C; Santoro, J P; Sapunenko, V; Sargsyan, M; Schumacher, R A; Serov, V S; Shafi, A; Sharabyan, Yu G; Shaw, J; Simionatto, S; Skabelin, A V; Smith, E S; Smith, L C; Sober, D I; Spraker, M; Stavinsky, A V; Stepanyan, S; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Todor, L; Tur, C; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Weller, H; Weygand, D P; Whisnant, C S; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zhang, B

    2004-01-01

    We have measured the 3He(e,e'pp)n reaction at 2.2 GeV over a wide kinematic range. The kinetic energy distribution for `fast' nucleons (p > 250 MeV/c) peaks where two nucleons each have 20% or less, and the third nucleon has most of the transferred energy. These fast pp and pn pairs are back-to-back with little momentum along the three-momentum transfer, indicating that they are spectators. Experimental and theoretical evidence indicates that we have measured distorted two-nucleon momentum distributions by striking the third nucleon and detecting the spectator correlated pair.

  4. Battery charger PP-4126()/U. Final report, 1 Jul 1969--30 Jul 1970

    Energy Technology Data Exchange (ETDEWEB)

    Froeschle, T.A.; Hill, H.W. Jr.

    1971-02-01

    The performance data and design configuration of the PP-4126 ()/U Battery Charger is delineated. Performance of the unit is summarized. Terminal performance and selected aspects of internal performance are considered. The internal system configuration of the battery charger is presented in block form. Functions of individual system blocks are discussed to define their behavior. Circuit components used to implement the system blocks are identified. The PP-4126 ()/U Battery Charger is designed to charge 6, 12, and 24 Vdc batteries at selectable charging rates from 0.1 Adc to 15 Adc. The battery charger operates from both dc and ac power sources. (auth)

  5. PP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease.

    Science.gov (United States)

    Descamps, Olivier; Spilman, Patricia; Zhang, Qiang; Libeu, Clare P; Poksay, Karen; Gorostiza, Olivia; Campagna, Jesus; Jagodzinska, Barbara; Bredesen, Dale E; John, Varghese

    2013-01-01

    A systematic approach was used to identify AβPP-selective BACE inhibitors (ASBI) and to evaluate their in vivo ability to modulate AβPP processing selectively. We identified a bioflavonoid nutritional supplement as a molecular lead that acts as an ASBI in cell models, and show that increasing brain levels of this bioflavonoid through a pro-drug approach leads to reduction of Aβ42 in an Alzheimer's disease mouse model. ASBIs represent a novel class of candidate therapeutic agents for Alzheimer's disease.

  6. Generalized pp-wave solutions on product of Ricci-flat spaces

    CERN Document Server

    Ivashchuk, V D

    2003-01-01

    A multidimensional gravitational model with several scalar fields and fields of forms is considered. A wide class of generalized pp-wave solutions defined on a product of n+1 Ricci-flat spaces is obtained. Certain examples of solutions (e.g. in supergravitational theories) are singled out. For special cone-type internal factor spaces the solutions are written in Brinkmann form. An example of pp-wave solution is obtained using Penrose limit of a solution defined on product of two Einstein spaces.

  7. Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.

    Science.gov (United States)

    Kaur, Amanpreet; Westermarck, Jukka

    2016-12-15

    Protein phosphatase 2A (PP2A) plays a major role in maintaining cellular signaling homeostasis by dephosphorylation of a variety of signaling proteins and acts as a tumor suppressor. Protein phosphatase methylesterase-1 (PME-1) negatively regulates PP2A activity by highly complex mechanisms that are reviewed here. Importantly, recent studies have shown that PME-1 promotes oncogenic MAPK/ERK and AKT pathway activities in various cancer types. In human glioma, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance. We discuss the emerging cancer-associated function of PME-1 and its potential clinical relevance.

  8. Functional barrier in two-layer recycled PP films for food packaging applications

    Science.gov (United States)

    Scarfato, P.; Di Maio, L.; Milana, M. R.; Feliciani, R.; Denaro, M.; Incarnato, L.

    2014-05-01

    A preliminary study on bi-layer virgin/contaminated polypropylene co-extruded films was performed in order to evaluate the possibility to realize an effective functional barrier in PP-based multi-layer systems. In particular, the specific migration in 10% v/v aqueous ethanol of two surrogate contaminants (phenyl-cyclohexane and benzophenone) contained in the contaminated layer across the PP functional barrier was measured at different times and the results were compared with those obtained from a contaminated mono-layer polypropylene film. Moreover, the thermal and mechanical performances of the produced films were investigated.

  9. Two-Nucleon Momentum Distributions Measured in 3He(e,e'pp)n

    Science.gov (United States)

    Niyazov, R. A.; Weinstein, L. B.; Adams, G.; Ambrozewicz, P.; Anciant, E.; Anghinolfi, M.; Asavapibhop, B.; Asryan, G.; Audit, G.; Auger, T.; Avakian, H.; Bagdasaryan, H.; Ball, J. P.; Barrow, S.; Battaglieri, M.; Beard, K.; Bektasoglu, M.; Bellis, M.; Benmouna, N.; Berman, B. L.; Bertozzi, W.; Bianchi, N.; Biselli, A. S.; Boiarinov, S.; Bonner, B. E.; Bouchigny, S.; Bradford, R.; Branford, D.; Brooks, W. K.; Burkert, V. D.; Butuceanu, C.; Calarco, J. R.; Carman, D. S.; Carnahan, B.; Cetina, C.; Chen, S.; Ciciani, L.; Cole, P. L.; Coleman, A.; Cords, D.; Corvisiero, P.; Crabb, D.; Crannell, H.; Cummings, J. P.; de Sanctis, E.; Dashyan, N.; Devita, R.; Degtyarenko, P. V.; Denizli, H.; Dennis, L.; Dharmawardane, K. V.; Dhuga, K. S.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dragovitsch, P.; Dugger, M.; Dytman, S.; Dzyubak, O. P.; Eckhause, M.; Egiyan, H.; Egiyan, K. S.; Elouadrhiri, L.; Empl, A.; Eugenio, P.; Fatemi, R.; Feuerbach, R. J.; Ficenec, J.; Forest, T. A.; Funsten, H.; Gavalian, G.; Gilad, S.; Gilfoyle, G. P.; Giovanetti, K. L.; Girard, P.; Gordon, C. I.; Gothe, R. W.; Griffioen, K.; Guidal, M.; Guillo, M.; Guo, L.; Gyurjyan, V.; Hadjidakis, C.; Hakobyan, R. S.; Hardie, J.; Heddle, D.; Hersman, F. W.; Hicks, K.; Holtrop, M.; Hu, J.; Hyde-Wright, C. E.; Ilieva, Y.; Ingram, W.; Ito, M. M.; Jenkins, D.; Joo, K.; Juengst, H. G.; Kelley, J. H.; Kellie, J.; Khandaker, M.; Kim, D. H.; Kim, K. Y.; Kim, K.; Kim, M. S.; Kim, W.; Klein, A.; Klein, F. J.; Klimenko, A. V.; Klusman, M.; Kossov, M.; Kramer, L. H.; Kuang, Y.; Kuhn, S. E.; Kuhn, J.; Lachniet, J.; Laget, J. M.; Langheinrich, J.; Lawrence, D.; Li, Ji; Livingston, K.; Lukashin, K.; Manak, J. J.; Marchand, C.; McAleer, S.; McLauchlan, S.; McNabb, J. W.; Mecking, B. A.; Mehrabyan, S.; Melone, J. J.; Mestayer, M. D.; Meyer, C. A.; Mikhailov, K.; Mirazita, M.; Miskimen, R.; Morand, L.; Morrow, S. A.; Muccifora, V.; Mueller, J.; Mutchler, G. S.; Napolitano, J.; Nasseripour, R.; Nelson, S. O.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niczyporuk, B. B.; Nozar, M.; O'Rielly, G. V.; Osipenko, M.; Park, K.; Pasyuk, E.; Peterson, G.; Philips, S. A.; Pivnyuk, N.; Pocanic, D.; Pogorelko, O.; Polli, E.; Pozdniakov, S.; Preedom, B. M.; Price, J. W.; Prok, Y.; Protopopescu, D.; Qin, L. M.; Raue, B. A.; Riccardi, G.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Ronchetti, F.; Rossi, P.; Rowntree, D.; Rubin, P. D.; Sabatié, F.; Sabourov, K.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Schumacher, R. A.; Serov, V. S.; Shafi, A.; Sharabian, Y. G.; Shaw, J.; Simionatto, S.; Skabelin, A. V.; Smith, E. S.; Smith, L. C.; Sober, D. I.; Spraker, M.; Stavinsky, A.; Stepanyan, S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Taylor, S.; Tedeschi, D. J.; Thoma, U.; Thompson, R.; Todor, L.; Tur, C.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Wang, K.; Weller, H.; Weygand, D. P.; Whisnant, C. S.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Yun, J.; Zhang, B.

    2004-02-01

    We have measured the 3He(e,e'pp)n reaction at 2.2GeV over a wide kinematic range. The kinetic energy distribution for “fast” nucleons (p>250 MeV/c) peaks where two nucleons each have 20% or less, and the third nucleon has most of the transferred energy. These fast pp and pn pairs are back to back with little momentum along the three-momentum transfer, indicating that they are spectators. Calculations by Sargsian and by Laget also indicate that we have measured distorted two-nucleon momentum distributions by striking one nucleon and detecting the spectator correlated pair.

  10. Asymmetry of prompt photon production in p-p collisions at RHIC

    CERN Document Server

    Skoro, G P; Tokarev, M V

    1999-01-01

    The prompt photon production in p-p collisions at high energies is studied. Double-spin asymmetry of the process is calculated by using Monte Carlo code SPHINX. A possibility to discriminate the spin-dependent gluon distributions and to determine sign of Delta G is discussed. Detailed study of expected background, such as pi0 production and decay, is given. The predictions for the longitudinal asymmetry of the prompt photons and pi0-meson production in the p-p collisions at RHIC energies have been made.

  11. Multiresolution imaging of mantle reflectivity structure using SS and P'P' precursors

    Science.gov (United States)

    Schultz, Ryan; Gu, Yu J.

    2013-10-01

    Knowledge of the mantle reflectivity structure is highly dependent on our ability to efficiently extract, and properly interpret, small seismic arrivals. Among the various data types and techniques, long-period SS/PP precursors and high-frequency receiver functions are routinely utilized to increase the confidence of the recovered mantle stratifications at distinct spatial scales. However, low resolution and a complex Fresnel zone are glaring weaknesses of SS precursors, while over-reliance on receiver distribution is a formidable challenge for the analysis of converted waves from oceanic regions. A promising high frequency alternative to receiver functions is P'P' precursors, which are capable of resolving mantle structures at vertical and lateral resolution of ˜5 and ˜200 km, respectively, owing to their spectral content, shallow angle of incidence and near-symmetric Fresnel zones. This study presents a novel processing method for both SS (or PP) and P'P' precursors based on deconvolution, stacking, Radon transform and depth migration. A suite of synthetic tests is performed to quantify the fidelity and stability of this method under different data conditions. Our multiresolution survey of the mantle at targeted areas near Nazca-South America subduction zone reveal both olivine and garnet related transitions at depths below 400 km. We attribute a depressed 660 to thermal variations, whereas compositional variations atop the upper-mantle transition zone are needed to explain the diminished or highly complex reflected/scattered signals from the 410 km discontinuity. We also observe prominent P'P' reflections within the transition zone, and the anomalous amplitudes near the plate boundary zone indicate a sharp (˜10 km thick) transition that likely resonates with the frequency content of P'P' precursors. The migration of SS precursors in this study shows no evidence of split 660 reflections, but potential majorite-ilmenite (590-640 km) and ilmenite

  12. Measurement of Solar pp-neutrino flux with Borexino: results and implications

    Science.gov (United States)

    Smirnov, O. Yu; Agostini, M.; Appel, S.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Chepurnov, A.; D'Angelo, D.; Davini, S.; Derbin, A.; Di Noto, L.; Drachnev, I.; Etenko, A.; Fomenko, K.; Franco, D.; Gabriele, F.; Galbiati, C.; Ghiano, C.; Giammarchi, M.; Goeger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Hungerford, E.; Ianni, Aldo; Ianni, Andrea; Jedrzejczak, K.; Kaiser, M.; Kobychev, V.; Korablev, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Lehnert, B.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, O.; Manecki, S.; Maneschg, W.; Marcocci, S.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Neumair, B.; Oberauer, L.; Obolensky, M.; Ortica, F.; Pallavicini, M.; Papp, L.; Perasso, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Roncin, R.; Rossi, N.; Schönert, S.; Semenov, D.; Simgen, H.; Skorokhvatov, M.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Thurn, J.; Toropova, M.; Unzhakov, E.; Vishneva, A.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Weinz, S.; Winter, J.; Wojcik, M.; Wurm, M.; Yokley, Z.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

    2016-02-01

    Measurement of the Solar pp-neutrino flux completed the measurement of Solar neutrino fluxes from the pp-chain of reactions in Borexino experiment. The result is in agreement with the prediction of the Standard Solar Model and the MSW/LMA oscillation scenario. A comparison of the total neutrino flux from the Sun with Solar luminosity in photons provides a test of the stability of the Sun on the 105 years time scale, and sets a strong limit on the power production by the unknown energy sources in the Sun.

  13. First real–time detection of solar pp neutrinos by Borexino

    Directory of Open Access Journals (Sweden)

    Pallavicini M.

    2016-01-01

    Full Text Available Solar neutrinos have been pivotal to the discovery of neutrino flavour oscillations and are a unique tool to probe the reactions that keep the Sun shine. Although most of solar neutrino components have been directly measured, the neutrinos emitted by the keystone pp reaction, in which two protons fuse to make a deuteron, have so far eluded direct detection. The Borexino experiment, an ultra–pure liquid scintillator detector running at the Laboratori Nazionali del Gran Sasso in Italy, has now filled the gap, providing the first direct real time measurement of pp neutrinos and of the solar neutrino luminosity.

  14. First real-time detection of solar pp neutrinos by Borexino

    Science.gov (United States)

    Pallavicini, M.; Bellini, G.; Benziger, J.; Bick, D.; Bonfini, G.; Bravo, D.; Caccianiga, B.; Calaprice, F.; Caminata, A.; Cavalcante, P.; Chavarria, A.; Chepurnov, A.; D'Angelo, D.; Davini, S.; Derbin, A.; Empl, A.; Etenko, A.; Fomenko, K.; Franco, D.; Gabriele, F.; Galbiati, C.; Gazzana, S.; Ghiano, C.; Giammarchi, M.; Göger-Neff, M.; Goretti, A.; Gromov, M.; Hagner, C.; Hungerford, E.; Ianni, Al.; Ianni, An.; Kayser, M.; Kobychev, V.; Korablëv, D.; Korga, G.; Kryn, D.; Laubenstein, M.; Lehnert, B.; Lewke, T.; Litvinovich, E.; Lombardi, F.; Lombardi, P.; Ludhova, L.; Lukyanchenko, G.; Machulin, I.; Manecki, S.; Maneschg, W.; Marcocci, S.; Meindl, Q.; Meroni, E.; Meyer, M.; Miramonti, L.; Misiaszek, M.; Montuschi, M.; Mosteiro, P.; Muratova, V.; Oberauer, L.; Obolensky, M.; Ortica, F.; Otis, K.; Papp, L.; Perasso, L.; Pocar, A.; Ranucci, G.; Razeto, A.; Re, A.; Romani, A.; Rossi, N.; Saldanha, R.; Salvo, C.; Schönert, S.; Simgen, H.; Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Sukhotin, S.; Suvorov, Y.; Tartaglia, R.; Testera, G.; Vignaud, D.; Vogelaar, R. B.; von Feilitzsch, F.; Wang, H.; Winter, J.; Wojcik, M.; Wurm, M.; Zaimidoroga, O.; Zavatarelli, S.; Zuber, K.; Zuzel, G.

    2016-07-01

    Solar neutrinos have been pivotal to the discovery of neutrino flavour oscillations and are a unique tool to probe the reactions that keep the Sun shine. Although most of solar neutrino components have been directly measured, the neutrinos emitted by the keystone pp reaction, in which two protons fuse to make a deuteron, have so far eluded direct detection. The Borexino experiment, an ultra-pure liquid scintillator detector running at the Laboratori Nazionali del Gran Sasso in Italy, has now filled the gap, providing the first direct real time measurement of pp neutrinos and of the solar neutrino luminosity.

  15. [PP]S类并联机构无伴随运动的结构条件%Structural Condition for [PP]S Parallel Mechanism without Parasitic Motion

    Institute of Scientific and Technical Information of China (English)

    李秦川; 陈志; 陈巧红; 武传宇; 黄真

    2010-01-01

    [PP]S类并联机构包括3-PRS、3-RPS、3-RRS和3-PPS四种构型,可实现1移动自由度和2转动自由度,具有广泛的应用前景.伴随运动是[PP]S类并联机构动平台在非独立自由度上发生的运动,是影响[PP]S类并联机构实际应用的关键问题.建立一般3-PRS并联机构伴随运动运动学模型,揭示出一般3-PRS并联机构各项几何结构参数与伴随运动的内在联系,证明3-PRS并联机构无伴随运动所必须满足的结构充要条件,根据这一结构条件可构建无伴随运动的3-PRS并联机构.指出无伴随运动的3-PRS并联机构中存在的局部自由度,给出考虑这一局部自由度的驱动选取方案,对无伴随运动的3-PRS并联机构进行自由度分析,并确定该类机构的2转动自由度的连续转轴.这一结构充要条件适用于全部[PP]S类并联机构.

  16. PP/UHMWPE共混合金增韧增强机理研究%Study on the Toughening and Strengthening Mechanisms of PP/UHMWPE Alloy

    Institute of Scientific and Technical Information of China (English)

    张青松

    2004-01-01

    探讨了PP/UHMWPE/LLDPE(聚丙烯/超高分子量聚乙烯/线性低密度聚乙烯)共混合金的力学性能与UHMWPE及LLDPE种类及含量的关系.发现UHMWPE对含有乙烯链节的共聚型PP有显著的增强增韧效果,UHMWPE的适当加入不但使基体的韧性得以提高,同时也可使其强度、模量、加工性能等得到改善.在PP/UHMWPE二元体系中加入适量的LLDPE,可改善二者的相容性,使体系韧性得到进一步提高.PP/UHMWPE合金的力学性能与二者间的熔体流动速率比(RM)存在一定规律性关系.在一定熔体流动速率(MFR)比值范围内,共混体系呈现脆-韧转变行为.当5<RM<15时,合金的综合力学性能较好.

  17. Polypropylene (PP) based proton exchange membrane for use in fuel cell; Obtencao de membrana trocadora de protons para uso em celula a combustivel, a base de polipropileno (PP)

    Energy Technology Data Exchange (ETDEWEB)

    Zen, Heloisa Augusto

    2008-07-01

    The radiation-induced graft of styrene onto polypropylene (PP) films was carried out by simultaneous irradiation method in a cobalt-60 source. The PP films were immersed in a solution of styrene with toluene (1:1 and 4:1, v/v) under inert atmosphere and at room temperature and then submitted at 20, 40, 80 and 100 kGy. After graft reaction the films were kept at room temperature under inert atmosphere for periods of 7, 14, 21 and 28 days in order to evaluate the degree of grafting. At the end of each period the films were sulfonated to provide the hydrophilic property to PP. The degree of grafting (DOG) was gravimetric determined and the chemical changes in the grafted and sulfonated films were characterized by Infrared Spectroscopy, Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry and the Ion Exchange Capacity (IEC) was calculated. The greatest DOG was obtained after 21 days of post-irradiation. By TGA the grafted films exhibited a decrease in the thermal stability, while the sulfonated exhibited an increase. By DSC was possible to verify that matrix polymeric did not suffer any drastic change in the melting temperature after grafting and sulfonation reactions. The IEC calculated shows that the new membrane developed has ionic conductivity property. (author)

  18. Multi-walled carbon nanotube filled polypropylene nanocomposites based on masterbatch route: Improvement of dispersion and mechanical properties through PP-g-MA addition

    Directory of Open Access Journals (Sweden)

    2008-10-01

    Full Text Available Multi-wall carbon nanotubes (MWNTs filled polypropylene (PP nanocomposites were prepared through diluting a PP/MWNT masterbatch in a PP matrix by melt compounding with a twin screw extruder. Polypropylene grafted maleic anhydride (PP-g-MA was used to promote the carbon nanotubes dispersion. The effect of PP-g-MA addition on the rheological, mechanical and morphological properties of the nanocomposites was assessed for different MWNTs loadings. Scanning electron microscopy (SEM has shown that nanotubes are distributed reasonably uniformly. A better dispersion and good adhesion between the nanotubes and the PP matrix is caused by wrapping of PP-g-MA on MWNTs. When PP-g-MA is added, dynamic moduli and viscosity further increases compared to PP/MWNT nanocomposites. The rheological percolation threshold drops significantly. Tensile and flexural moduli and Charpy impact resistance of the nanocomposites also increases by the addition of PP-g-MA. The present study confirms that PP-g-MA is efficient to promote the dispersion of MWNTs in PP matrix and serves as an adhesive to increase their interfacial strength, hence greatly improving the rheological percolation threshold and mechanical properties of PP/MWNT nanocomposites.

  19. Peter Berger, Grace Davie & Effie Fokas, Religious America, Secular Europe? A Theme and Variations (Aldershot: Ashgate, 2008), 168 pp

    DEFF Research Database (Denmark)

    Lüchau, Peter

    2012-01-01

    Anmeldelse af bogen: Peter Berger, Grace Davie & Effie Fokas, Religious America, Secular Europe? A Theme and Variations (Aldershot: Ashgate, 2008), 168 pp.......Anmeldelse af bogen: Peter Berger, Grace Davie & Effie Fokas, Religious America, Secular Europe? A Theme and Variations (Aldershot: Ashgate, 2008), 168 pp....

  20. Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation

    DEFF Research Database (Denmark)

    Zlocowski, Natacha; Sendra, Victor G; Lorenz, Virginia;

    2011-01-01

    Post-translational acetylation is an important molecular regulatory mechanism affecting the biological activity of proteins. Polypeptide GalNAc transferases (ppGalNAc-Ts) are a family of enzymes that catalyze initiation of mucin-type O-glycosylation. All ppGalNAc-Ts in mammals are type II...... of the R-type lectin domain of ppGalNAc-T2. Acetylation effect on ppGalNAc-T2 biological activity in vitro was studied using a purified human recombinant ppGalNAc-T2. Mass spectrometric analysis of acetylated ppGalNAc-T2 revealed seven acetylated amino acids (K103, S109, K111, K363, S373, K521, and S529......); the first five are located in the catalytic domain. Specific glycosyltransferase activity of ppGalNAc-T2 was reduced 95% by acetylation. The last two amino acids, K521 and S529, are located in the lectin domain, and their acetylation results in alteration of the carbohydrate-binding ability of ppGalNAc-T2...

  1. Understanding the Reinforcing Mechanisms in Kenaf Fiber/PLA and Kenaf Fiber/PP Composites: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Seong Ok Han

    2012-01-01

    Full Text Available This study focused on exploring the feasibility of green composites made from biodegradable and renewable materials as potential alternatives to petroleum polymer composites and understanding the reinforcing mechanisms in composites containing kenaf fibers (KF. KF-reinforced poly(lactide acid (PLA composites were made using melt compounding and injection molding, and their properties were compared to that of KF-reinforced polypropylene (PP composites. The flexural properties and thermomechanical behavior were determined as a function of the fiber content, the crystallization of PLA and PP was studied using X-ray diffraction and differential scanning calorimetry, and the composites’ morphology was investigated using scanning electron microscopy. It was concluded that PLA exhibits higher modulus and Tg compared to those of neat PP. The modulus of the composites at 40 wt% fibers is 6.64 GPa and 2.96 GPa for PLA and PP, respectively. In general, addition of kenaf results in larger property enhancement in PP due to better wetting of the fibers by the low melt viscosity PP and the crystallization behavior of PP that is significantly altered by the fibers. The novelty of this work is that it provides one-to-one comparison of PLA and PP composites, and it explores the feasibility of fabricating green composites with enhanced properties using a simple scalable process.

  2. The magic spot: identification of the binding site for ppGpp on E. coli RNA polymerase

    Science.gov (United States)

    Despite more than 40 years of study of the global regulatory nucleotide ppGpp ("magic spot") in Escherichia coli, its target site on RNA polymerase (RNAP), and therefore its mechanism of action, is unknown. We report here a binding site for ppGpp on E. coli RNAP, identified by crosslinking, protease...

  3. Structure and properties of special PP resin B4908 for infusion bottles%输液瓶专用PP B4908的结构与性能

    Institute of Scientific and Technical Information of China (English)

    陈秀娟

    2015-01-01

    改进了输液瓶专用聚丙烯(PP)B4908的结构和性能,并与进口同类PP进行对比分析。通过调整乙烯含量, B4908的透明性与熔体拉伸张力较改进前有所提高,且优于进口同类PP;B4908与进口同类PP的的剪切黏度、剪切应力随剪切速率(γ)增大而变化的趋势基本一致,说明其对温度、γ的敏感性基本相当;改进后B4908-G的熔体拉伸张力较改进前提高约35%,说明改进后B4908-G在加热熔融时的抗拉伸性能和抗熔垂性能较好,有利于医药品包装生产厂家生产输液瓶;B4908的综合力学性能优于进口同类PP。%The structure and properties of special polypropylene(PP) resin B4908 for infusion bottles were improved and compared with those of similar import PP. The transparency and melt tension of B4908 were increased and superior to those of the import counterpart by adjusting the content of ethylene. The change tendency of shear viscosity and shear stress versus shear rate of B4908 was essentially in agreement with that of similar import PP,indicating that the two resins had similar sensitivity to temperature and shear rate. The melt tension of the improved PP B4908-G was increased by 35% in comparison with that of the original B4908,indicating that the improved PP B4908-G had better anti-tensile properties and sag resistance performance during heating and melting process and consequently benefited production of infusion bottle manufacturers. B4908 was superior to the import counterpart in comprehensive mechanical properties.

  4. Importance of the ammonia assimilation by Penicillium purpurogenum in amino derivative Monascus pigment, PP-V, production.

    Science.gov (United States)

    Arai, Teppei; Koganei, Kasumi; Umemura, Sara; Kojima, Ryo; Kato, Jun; Kasumi, Takafumi; Ogihara, Jun

    2013-03-28

    A fungal strain, Penicillium purpurogenum IAM 15392, produced the azaphilone Monascus pigment homolog when cultured in a medium composed of soluble starch, ammonium nitrate, yeast extract, and citrate buffer, pH 5.0. One of the typical features of violet pigment PP-V [(10Z)-12- carboxyl-monascorubramine] is that pyranoid oxygen is replaced with nitrogen. In this study, we found that glutamine synthetase (glnB) and glutamate dehydrogenase (gdh1) genes were expressed in the culture conditions conducive to PP-V production. Gln and Glu both support PP-V biosynthesis, but PP-V biosynthesis was much more efficient with Gln. We determined that synthesis of Gln by glutamine synthetase from ammonium is important for PP-V production.

  5. The upcycling of post-industrial PP/PET waste streams through in-situ microfibrillar preparation

    Energy Technology Data Exchange (ETDEWEB)

    Delva, Laurens, E-mail: Laurens.Delva@ugent.be; Ragaert, Kim, E-mail: Kim.Ragaert@ugent.be; Cardon, Ludwig, E-mail: Ludwig.Cardon@ugent.be [Centre for Polymer and Materials Technologies (CPMT), Department of Materials Science and Engineering, Ghent University, Technologiepark 915, 9052 Zwijnaarde (Belgium)

    2015-12-17

    Post-industrial plastic waste streams can be re-used as secondary material streams for polymer processing by extrusion or injection moulding. One of the major commercially available waste stream contains polypropylene (PP) contaminated with polyesters (mostly polyethylene tereftalate - PET). An important practical hurdle for the direct implementation of this waste stream is the immiscibility of PP and PET in the melt, which leads to segregation within the polymer structure and adversely affects the reproducibility and mechanical properties of the manufactured parts. It has been indicated in literature that the creation of PET microfibrils in the PP matrix could undo these drawbacks and upcycle the PP/PET combination. Within the current research, a commercially available virgin PP/PET was evaluated for the microfibrillar preparation. The mechanical (tensile and impact) properties, thermal properties and morphology of the composites were characterized at different stages of the microfibrillar preparation.

  6. PP2A targeting by viral proteins: a widespread biological strategy from DNA/RNA tumor viruses to HIV-1.

    Science.gov (United States)

    Guergnon, Julien; Godet, Angélique N; Galioot, Amandine; Falanga, Pierre Barthélémy; Colle, Jean-Hervé; Cayla, Xavier; Garcia, Alphonse

    2011-11-01

    Protein phosphatase 2A (PP2A) is a large family of holoenzymes that comprises 1% of total cellular proteins and accounts for the majority of Ser/Thr phosphatase activity in eukaryotic cells. Although initially viewed as constitutive housekeeping enzymes, it is now well established that PP2A proteins represent a family of highly and sophistically regulated phosphatases. The past decade, multiple complementary studies have improved our knowledge about structural and functional regulation of PP2A holoenzymes. In this regard, after summarizing major cellular regulation, this review will mainly focus on discussing a particulate biological strategy, used by various viruses, which is based on the targeting of PP2A enzymes by viral proteins in order to specifically deregulate, for their own benefit, cellular pathways of their hosts. The impact of such PP2A targeting for research in human diseases, and in further therapeutic developments, is also discussed.

  7. Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

    Science.gov (United States)

    Katayama, Kazuhiro; Yamaguchi, Miho; Noguchi, Kohji; Sugimoto, Yoshikazu

    2014-04-01

    P-glycoprotein (P-gp)/ABCB1 is a key molecule of multidrug resistance in cancer. Protein phosphatase (PP) 2A, regulatory subunit B, gamma (PPP2R3C), which is a regulatory subunit of PP2A and PP5, was identified as a binding candidate to P-gp. Immunoprecipitation-western blotting revealed that PP5 and PPP2R3C were coprecipitated with P-gp, while PP2A was not. PP5/PPP2R3C dephosphorylated protein kinase A/protein kinase C-phosphorylation of P-gp. Knockdown of PP5 and/or PPP2R3C increased P-gp expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, our results indicate that PP5/PPP2R3C negatively regulates P-gp expression and function.

  8. A role for protein phosphatase PP1γ in SMN complex formation and subnuclear localization to Cajal bodies.

    Science.gov (United States)

    Renvoisé, Benoît; Quérol, Gwendoline; Verrier, Eloi Rémi; Burlet, Philippe; Lefebvre, Suzie

    2012-06-15

    The spinal muscular atrophy (SMA) gene product SMN forms with gem-associated protein 2-8 (Gemin2-8) and unrip (also known as STRAP) the ubiquitous survival motor neuron (SMN) complex, which is required for the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), their nuclear import and their localization to subnuclear domain Cajal bodies (CBs). The concentration of the SMN complex and snRNPs in CBs is reduced upon SMN deficiency in SMA cells. Subcellular localization of the SMN complex is regulated in a phosphorylation-dependent manner and the precise mechanisms remain poorly understood. Using co-immunoprecipitation in HeLa cell extracts and in vitro protein binding assays, we show here that the SMN complex and its component Gemin8 interact directly with protein phosphatase PP1γ. Overexpression of Gemin8 in cells increases the number of CBs and results in targeting of PP1γ to CBs. Moreover, depletion of PP1γ by RNA interference enhances the localization of the SMN complex and snRNPs to CBs. Consequently, the interaction between SMN and Gemin8 increases in cytoplasmic and nuclear extracts of PP1γ-depleted cells. Two-dimensional protein gel electrophoresis revealed that SMN is hyperphosphorylated in nuclear extracts of PP1γ-depleted cells and expression of PP1γ restores these isoforms. Notably, SMN deficiency in SMA leads to the aberrant subcellular localization of Gemin8 and PP1γ in the atrophic skeletal muscles, suggesting that the function of PP1γ is likely to be affected in disease. Our findings reveal a role of PP1γ in the formation of the SMN complex and the maintenance of CB integrity. Finally, we propose Gemin8 interaction with PP1γ as a target for therapeutic intervention in SMA.

  9. MS_RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis.

    Science.gov (United States)

    Murdeshwar, Maya S; Chatterji, Dipankar

    2012-08-01

    In the noninfectious soil saprophyte Mycobacterium smegmatis, intracellular levels of the stress alarmones guanosine tetraphosphate and guanosine pentaphosphate, together termed (p)ppGpp, are regulated by the enzyme Rel(Msm). This enzyme consists of a single, bifunctional polypeptide chain that is capable of both synthesizing and hydrolyzing (p)ppGpp. The rel(Msm) knockout strain of M. smegmatis (Δrel(Msm)) is expected to show a (p)ppGpp null [(p)ppGpp(0)] phenotype. Contrary to this expectation, the strain is capable of synthesizing (p)ppGpp in vivo. In this study, we identify and functionally characterize the open reading frame (ORF), MSMEG_5849, that encodes a second functional (p)ppGpp synthetase in M. smegmatis. In addition to (p)ppGpp synthesis, the 567-amino-acid-long protein encoded by this gene is capable of hydrolyzing RNA·DNA hybrids and bears similarity to the conventional RNase HII enzymes. We have classified this protein as actRel(Msm) in accordance with the recent nomenclature proposed and have named it MS_RHII-RSD, indicating the two enzymatic activities present [RHII, RNase HII domain, originally identified as domain of unknown function 429 (DUF429), and RSD, RelA_SpoT nucleotidyl transferase domain, the SYNTH domain responsible for (p)ppGpp synthesis activity]. MS_RHII-RSD is expressed and is constitutively active in vivo and behaves like a monofunctional (p)ppGpp synthetase in vitro. The occurrence of the RNase HII and (p)ppGpp synthetase domains together on the same polypeptide chain is suggestive of an in vivo role for this novel protein as a link connecting the essential life processes of DNA replication, repair, and transcription to the highly conserved stress survival pathway, the stringent response.

  10. Diversity in guanosine 3',5'-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants.

    Science.gov (United States)

    Nomura, Yuhta; Izumi, Atsushi; Fukunaga, Yoshinori; Kusumi, Kensuke; Iba, Koh; Watanabe, Seiya; Nakahira, Yoichi; Weber, Andreas P M; Nozawa, Akira; Tozawa, Yuzuru

    2014-05-30

    The guanosine 3',5'-bisdiphosphate (ppGpp) signaling system is shared by bacteria and plant chloroplasts, but its role in plants has remained unclear. Here we show that guanylate kinase (GK), a key enzyme in guanine nucleotide biosynthesis that catalyzes the conversion of GMP to GDP, is a target of regulation by ppGpp in chloroplasts of rice, pea, and Arabidopsis. Plants have two distinct types of GK that are localized to organelles (GKpm) or to the cytosol (GKc), with both enzymes being essential for growth and development. We found that the activity of rice GKpm in vitro was inhibited by ppGpp with a Ki of 2.8 μM relative to the substrate GMP, whereas the Km of this enzyme for GMP was 73 μM. The IC50 of ppGpp for GKpm was ∼10 μM. In contrast, the activity of rice GKc was insensitive to ppGpp, as was that of GK from bakers' yeast, which is also a cytosolic enzyme. These observations suggest that ppGpp plays a pivotal role in the regulation of GTP biosynthesis in chloroplasts through specific inhibition of GKpm activity, with the regulation of GTP biosynthesis in chloroplasts thus being independent of that in the cytosol. We also found that GKs of Escherichia coli and Synechococcus elongatus PCC 7942 are insensitive to ppGpp, in contrast to the ppGpp sensitivity of the Bacillus subtilis enzyme. Our biochemical characterization of GK enzymes has thus revealed a novel target of ppGpp in chloroplasts and has uncovered diversity among bacterial GKs with regard to regulation by ppGpp.

  11. Restrictions on pp scattering amplitude imposed by first diffraction minimum data obtained by TOTEM at LHC

    CERN Document Server

    Kovalenko, V N; Vechernin, V V; Diatchenko, D V

    2015-01-01

    Recently, fine experimental data on the behavior of elastic scattering cross section in the region of the diffraction peak and the first diffraction minimum was obtained by the TOTEM experiment for 7 TeV pp collisions at the LHC [1, 2]. The first restrictions on pp scattering amplitude imposed by this data were discussed in [3, 4]. In the present work we present the systematic analysis of the problem in the framework of quasi-eikonal Regge approach [5, 6] taking into account the unitarity condition. We show that although in this approach one can describe the general features of the pp scattering such as the total elastic and inelastic cross sections, the slope of diffraction cone and the multiplicity density at mid-rapidities [7], nevertheless the behavior of pp elastic differential cross section in the vicinity of the first diffraction minimum measured by the TOTEM experiment at LHC [1, 2] can not be reproduced under any parameter values at standard assumptions of the model. Physically one can say that in qu...

  12. Characterization of gamma-stabilized PP with blends of hindered amine/phenolic stabilizers

    Energy Technology Data Exchange (ETDEWEB)

    Albano, C. [Centro de Quimica, Laboratorio de Polimeros, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas (Venezuela); Universidad Central de Venezuela, Facultad de Ingenieria, Escuela de Ingenieria Quimica, Caracas (Venezuela)], E-mail: calbano@ivic.ve; Perera, R. [Departamento de Mecanica, Universidad Simon Bolivar, Caracas (Venezuela)], E-mail: rperera@usb.ve; Karam, A.; Sanchez, Y. [Centro de Quimica, Laboratorio de Polimeros, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas (Venezuela); Silva, P. [Centro de Fisica, Laboratorio de la Materia Condensada, Instituto Venezolano de Investigaciones Cientificas, Caracas (Venezuela)

    2007-12-15

    In this work, the effect of {gamma} radiation at doses of 25 and 50 kGy on polypropylene (PP) stabilized with a binary system of antioxidants of the phenol-hindered amine type (BHT-Chimassorb 994) at different compositions (0.1/0.2, 0.1/0.5, 0.1/0.8) was studied. The results showed that the carbonyl index (I{sub c}) of the stabilized samples drastically decreases when compared to that of the pure PP sample. Nonetheless, the I{sub c} values of the different stabilized samples were very similar after irradiation. On the other hand, the average molecular weights (M{sub w} and M{sub n}) and melt flow index (MFI) values decrease in all the samples after irradiation. This effect is less pronounced in PP with 0.1/0.8 of the binary blend of antioxidants. The melting and crystallization peak temperatures and the crystallinity degree remained almost unchanged and the tensile properties such as Young's modulus and tensile strength did not vary either, except for the elongation at break, which decreases in less proportion in those blends of PP with the antioxidants, independently of the absorbed dose.

  13. ALICE event displays in pp collisions at 7 TeV

    CERN Multimedia

    Kalweit, Alexander Philipp

    2015-01-01

    Events with low, medium and high multiplicities in pp collisions at 7 TeV, recorded at the LHC by ALICE in June 2010. The big cylinder is the Time Projection Chamber of ALICE, with a diameter of 5 m and a length of 5 m, the inner red-green-blue cylinders are the Inner Tracking System.

  14. Clan structure analysis and new physics signals in pp collisions at LHC

    CERN Document Server

    Giovannini, Alberto; Giovannini, Alberto; Ugoccioni, Roberto

    2005-01-01

    The study of possible new physics signals in global event properties in pp collisions in full phase space and in rapidity intervals accessible at LHC is presented. The main characteristic is the presence of an elbow structure in final charged particle MD's in addition to the shoulder observed at lower c.m. energies.

  15. First Trimester Maternal Serum PP13 in the Risk Assessment for Preeclampsia

    Science.gov (United States)

    ROMERO, Roberto; KUSANOVIC, Juan Pedro; THAN, Nandor Gabor; EREZ, Offer; GOTSCH, Francesca; ESPINOZA, Jimmy; EDWIN, Samuel; CHEFETZ, Ilana; GOMEZ, Ricardo; NIEN, Jyh Kae; SAMMAR, Marei; PINELES, Beth; HASSAN, Sonia S.; MEIRI, Hamutal; TAL, Yossi; KUHNREICH, Ido; PAPP, Zoltan; CUCKLE, Howard S.

    2008-01-01

    Objective To determine whether first trimester maternal serum Placental Protein 13 (PP13) concentrations can be used in the risk assessment for preeclampsia. Study Design This case-control study included 50 patients with preeclampsia and 250 patients with normal pregnancies. Samples were collected between 8-13 weeks of gestation. Serum PP13 concentrations were measured by ELISA and expressed as medians and multiples of the median (MoM) for gestational age. Sensitivity and specificity were derived from receiver operating characteristic curve analysis. Results 1) Serum PP13 concentration in the first trimester was significantly lower in patients who developed preterm and early-onset preeclampsia than in those with normal pregnancies; and 2) At 80% specificity, a cutoff of 0.39 MoM had a sensitivity of 100% for early-onset preeclampsia and 85% for preterm preeclampsia. Conclusion Maternal serum first trimester PP13 appears to be a reasonable marker for risk assessment, but a weak marker for severe preeclampsia at term, and ineffective for identifying mild preeclampsia at term. PMID:18539259

  16. Recent functional insights into the role of (p)ppGpp in bacterial physiology

    DEFF Research Database (Denmark)

    Hauryliuk, Vasili; Atkinson, Gemma C.; Murakami, Katsuhiko S.

    2015-01-01

    The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively referred to as (p)ppGpp) are involved in regulating growth and several different stress responses in bacteria. In recent years, substantial progress has been made in our understanding of the molecular mechanisms of ...

  17. Influence of flavour absorption on oxygen permentation through LDPE, PP, PC and PET plastics food packaging

    NARCIS (Netherlands)

    Willige, van R.W.G.; Linssen, J.P.H.; Meinders, M.B.J.; Stege, van der H.J.; Voragen, A.G.J.

    2002-01-01

    The effect of flavour absorption on the oxygen permeability of low-density polyethylene (LDPE), polypropylene (PP), polycarbonate (PC) and polyethylene terephthalate (PET) was studied using an isostatic continuous flow system. Polymer samples were exposed to a model solution containing limonene,

  18. A Simple Explanation of Negative Correlation Data in p^^-p Annihilations

    OpenAIRE

    Hujio, NODA; Department of Physics, Ibaraki University

    1983-01-01

    Negative correlation data in p^^-p annihilations at low energies are explained by a simple model, in which the normalized cross section for the negative-charged multiplicity is represented by binomial distribution. It satisfies the multiplicity cutoff required by the energy conservation and shows an approximate KNO scaling.

  19. F-string Solution in AdS4 X CP3 PP-wave Background

    CERN Document Server

    Banerjee, Gourav

    2016-01-01

    We present supergravity solution for F-string in pp wave background obtained from AdS4 X CP3 with zero flat directions.The classical solution is shown to break all space-time supersymmetries. We explicitly write down the standard as well as supernumerary Killing spinors both for the background and F-string solution.

  20. Statistical model predictions for p+p and Pb+Pb collisions at LHC

    NARCIS (Netherlands)

    Kraus, I.; Cleymans, J.; Oeschler, H.; Redlich, K.; Wheaton, S.

    2009-01-01

    Particle production in p+p and central collisions at LHC is discussed in the context of the statistical thermal model. For heavy-ion collisions, predictions of various particle ratios are presented. The sensitivity of several ratios on the temperature and the baryon chemical potential is studied in

  1. Morphology and thermal properties of compatibilized PA12/PP blends with boehmite alumina nanofiller inclusions

    CSIR Research Space (South Africa)

    Ogunniran, ES

    2011-12-01

    Full Text Available -1 Morphology and Thermal Properties of Compatibilized PA12/PP Blends with Boehmite Alumina Nanofiller Inclusions 1. Elijah Soba Ogunniran1, 2. Rotimi Sadiku1, 3. Suprakas Sinha Ray2,*, 4. Nyambeni Luruli3 Keywords: ? boehmite alumina; ? morphology...

  2. Terahertz and M4PP conductivity mapping of large area CVD grown graphene films

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Petersen, Dirch Hjorth; Bøggild, Peter;

    We demonstrate mapping of magnitude and variation of the electrical conductance of large area CVD graphene films by terahertz time-domain spectroscopy (THz-TDS) and micro four-point-probe (M4PP). Non-trivial correlations between results obtained with the two techniques are discussed in relation...

  3. Influence of electron beam Irradiation on PP/Piassava fiber composite prepared by melt extrusion process

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Michelle G.; Ferreira, Maiara S.; Oliveira, Rene R.; Silva, Valquiria A.; Teixeira, Jaciele G.; Moura, Esperidiana A.B., E-mail: michellegoncalvesgomes@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    In the latest years, the interest for the use of natural fibers in materials composites polymeric has increased significantly due to their environmental and technological advantages. Piassava fibers (Attalea funifera) have been used as reinforcement in the matrix of thermoplastic and thermoset polymers. In the present work (20%, in mass), piassava fibers with particle sizes equal or smaller than 250 μm were incorporated in the polypropylene matrix (PP) no irradiated and polypropylene matrix containing 10 % and 30 % of polypropylene treated by electron-beam radiation at 40 kGy (PP/PPi/Piassava). The composites PP/Piassava and PP/PPi/Piassava were prepared by using a twin screw extruder, followed by injection molding. The composite material samples obtained were treated by electron-beam radiation at 40 kGy, using a 1.5 MeV electron beam accelerator, at room temperature, in presence of air. After irradiation treatment, the irradiated and non-irradiated specimens tests samples were submitted to thermo-mechanical tests, melt flow index (MFI), sol-gel analysis, X-Ray diffraction (XRD) and scanning electron microscopy (SEM). (author)

  4. Measurement of the s dependence of jet production at the CERN pp collider

    DEFF Research Database (Denmark)

    Appel, J.A.; Bagnaia, P.; Banner, M.

    1985-01-01

    The production of very large transverse momentum (pT) hadron jets has been measured in the UA2 experiment at the CERN pp Collider for s=630 GeV. The inclusive jet production cross sections exhibit a pT-dependent increase with respect to the s=546 GeV data from previous Collider runs. This increas...

  5. EFFECTS OF COUPLING AGENTS ON THE CRYSTALLIZATION BEHAVIOR OF PP/T-ZnOw COMPOSITES

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The objectives of this paper are to understand the crystallization behavior of polypropylene (PP) composites with surface modified tetra-needle-shaped zinc oxide whisker (T-ZnOw). T-ZnOw was surface modified with different coupling agents, such as silane coupling agents (KH-550, KH-560) and titanate coupling agent (NDZ-105), in order to improve the compatibility between PP and T-ZnOw. DSC and POM were used to characterize the melt and crystallization behavior and the crystalline structures of the composites, respectively. The results show that the surface modified T-ZnOw acts as a nucleating agent of PP crystallization, depending on the coupling agent used for modification. KH-550 and KH-560 have more apparent role in improving the interfacial interaction than NDZ-105 and induce PP crystallization at higher temperature and with smaller spherulites size. The results also suggest that the crystallization behavior depends on not only the content of coupling agent, but also the content of the surface modified T-ZnOw used in the composites.

  6. EVENT STRUCTURE AT RHIC FROM P-P TO AU-AU.

    Energy Technology Data Exchange (ETDEWEB)

    TRAINOR,T.A.; (FOR THE STAR COLLABORATION)

    2004-03-15

    Several correlation analysis techniques are applied to p-p and Au-Au collisions at RHIC. Strong large-momentum-scale correlations are observed which can be related to local charge and momentum conservation during hadronization and to minijet (minimum-bias parton fragment) correlations.

  7. Inclusive jet cross-section and a search for quark compositeness at the CERN pp Collider

    Science.gov (United States)

    Alitti, J.; Ansari, R.; Autiero, D.; Bareyre, P.; Blaylock, G.; Bonamy, P.; Bonesini, M.; Borer, K.; Bourliaud, M.; Buskulic, D.; Carboni, G.; Cavalli, D.; Cavasinni, V.; Cenci, P.; Chollet, J. C.; Conta, C.; Costa, G.; Costantini, F.; dell'Acqua, A.; Delprete, T.; Dewolf, R. S.; Dilella, L.; Egan, G. F.; Einsweiler, K. F.; Fayard, L.; Federspiel, A.; Ferrari, R.; Fraternali, M.; Froidevaux, D.; Fumaglli, G.; Gaillard, J. M.; Gianotti, F.; Gildemeister, O.; Gössling, C.; Goggi, V. G.; Grünendahl, S.; Hara, K.; Hellman, S.; Hugentobler, E.; Hultqvist, K.; Iacopini, E.; Incandela, J.; Jakobs, K.; Jenni, P.; Kluge, E. E.; Kurz, N.; Lami, S.; Lariccia, P.; Lefebvre, M.; Linssen, L.; Livan, M.; Lubrano, P.; Magneville, C.; Mandelli, L.; Mapelli, L.; Mazzanti, M.; Meier, K.; Merkel, B.; Meyer, J. P.; Moniez, M.; Moning, R.; Morganti, M.; Müller, L.; Munday, D. J.; Nessi, M.; Nessi-Tedaldi, F.; Onions, C.; Pal, T.; Parker, M. A.; Parrour, G.; Pastore, F.; Pennacchio, E.; Pentney, J. M.; Pepe, M.; Perini, L.; Petridou, C.; Petroff, P.; Plothow-Besch, H.; Polesello, G.; Poppleton, A.; Pretzl, K.; Primavera, M.; Punturo, M.; Rasmussen, L.; Repellin, J. P.; Rimoldi, A.; Scampoli, P.; Schacher, J.; Singh, S. L.; Stapnes, S.; Stirling, A. V.; Tondini, F.; Tovey, S. N.; Tsesmelis, E.; Unal, G.; Valdata-Nappi, M.; Vercesi, V.; Weidberg, A. R.; Wells, P. S.; White, T. O.; Wood, D. R.; Wotton, S. A.; Zaccone, H.

    1991-03-01

    The inclusive jet cross-section has been measured at the CERN pp Collider (sqrt(s) = 630 GeV) as a function of the jet transverse momentum (pT) and pseudorapidity (η) for pT values up to 180 GeV and for-2825 GeV (95% CL) is set on the quark compositeness scale Λc.

  8. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.

    Science.gov (United States)

    Kunda, Patricia; Rodrigues, Nelio T L; Moeendarbary, Emadaldin; Liu, Tao; Ivetic, Aleksandar; Charras, Guillaume; Baum, Buzz

    2012-02-01

    Animal cells undergo dramatic actin-dependent changes in shape as they progress through mitosis; they round up upon mitotic entry and elongate during chromosome segregation before dividing into two [1-3]. Moesin, the sole Drosophila ERM-family protein [4], plays a critical role in this process, through the construction of a stiff, rounded metaphase cortex [5-7]. At mitotic exit, this rigid cortex must be dismantled to allow for anaphase elongation and cytokinesis through the loss of the active pool of phospho-Thr559moesin from cell poles. Here, in an RNA interference (RNAi) screen for phosphatases involved in the temporal and spatial control of moesin, we identify PP1-87B RNAi as having elevated p-moesin levels and reduced cortical compliance. In mitosis, RNAi-induced depletion of PP1-87B or depletion of a conserved noncatalytic PP1 phosphatase subunit Sds22 leads to defects in p-moesin clearance from cell poles at anaphase, a delay in anaphase elongation, together with defects in bipolar anaphase relaxation and cytokinesis. Importantly, similar cortical defects are seen at anaphase following the expression of a constitutively active, phosphomimetic version of moesin. These data reveal a new role for the PP1-87B/Sds22 phosphatase, an important regulator of the metaphase-anaphase transition, in coupling moesin-dependent cell shape changes to mitotic exit.

  9. Tensile and impact properties of three-component PP/wood/elastomer composites

    Directory of Open Access Journals (Sweden)

    B. Pukanszky

    2012-03-01

    Full Text Available Polypropylene (PP was reinforced with wood flour and impact modified with elastomers to increase stiffness and impact resistance simultaneously. Elastomer content changed in four (0, 5, 10 and 20 wt%, while that of wood content in seven steps, the latter from 0 to 60 wt% in 10 wt% steps. Structure and adhesion were controlled by the addition of functionalized (maleated polymers. Composites were homogenized in a twin-screw extruder and then injection molded to tensile bars. Fracture resistance was characterized by standard and instrumented impact tests. The results showed that the components are dispersed independently of each other even when a functionalized elastomer is used for impact modification, at least under the conditions of this study. Impact resistance does not change much as a function of wood content in PP/wood composites, but decreases drastically from the very high level of the PP/elastomer blend to almost the same value obtained without impact modifier in the three-component materials. Increasing stiffness and fiber related local deformation processes led to small fracture toughness at large wood content. Micromechanical deformation processes depend mainly on the strength of PP/wood interaction; debonding and pull-out take place at poor adhesion, while fiber fracture dominates when adhesion is strong. Composites with sufficiently large impact resistance cannot be prepared in the usual range of wood contents (50–60 wt%.

  10. Search for the kaonic bound state ppK- in pp→ pK +Λ

    Science.gov (United States)

    Münzer, Robert; Epple, Eliane; Fabbietti, Laura

    2015-08-01

    The investigation of the kaon-nucleon interaction has been intensified in the last years due to new measurements of the Λ(1405) resonance and indications on the existence of the ppK- bound state. Such results are heavily discussed, since they can lead to new knowledge about the -Nucleon interaction. In the last years, the reaction p+p →p+ K+ + Λ has been measured at the GSI Helmholtzcentre in Darmstadt with the FOPI and the HADES spectrometers at beam energies of 3.1 GeV and 3.5 GeV, respectively. New analyses methods have been developed to understand quantitatively all the processes contributing to the pK+Λ final state. At the FOPI experiment a set of around 1.000 events and in the HADES experiment around 22.000 events of the exclusive reaction p+p →p+ K+ + Λ could be extracted. These reconstructed exclusive events were analyzed within the Bonn Gatchina Partial Wave Analysis (BG-PWA) framework, which provides a coherent description of the data including several resonant and non-resonant production channels. The results have shown that the inclusion of interferences between different channels has to be considered in the analysis. Based on the description of the data with the Partial Wave Analysis an upper limit on the cross-section for the production of the ppK- could be determined.

  11. Bulk Observables in pp, dA and AA Collisions at RHIC

    CERN Document Server

    Hofman, D J; Ballintijn, M; Barton, D S; Becker, B; Betts, R R; Bickley, A A; Bindel, R; Budzanowski, A; Busza, W; Carroll, A; Decowski, M P; García, E; Gburek, T; George, N; Gulbrandsen, K H; Gushue, S; Halliwell, C; Hamblen, J; Harrington, A S; Heintzelman, G A; Henderson, C; Hollis, R S; Holynski, R; Holzman, B; Iordanova, A; Johnson, E; Kane, J L; Katzy, J; Khan, N; Kucewicz, W; Kulinich, P; Kuo, C M; Lee, J W; Lin, W T; Manly, S; McLeod, D; Mignerey, A C; Nouicer, R; Olszewski, A; Pak, R; Park, I C; Pernegger, H; Reed, C; Remsberg, L P; Reuter, M; Roland, C; Roland, G; Rosenberg, L J; Sagerer, J; Sarin, P; Sawicki, P; Sedykh, I; Skulski, W; Smith, C E; Steinberg, P; Stephans, G S F; Sukhanov, A; Tang, J L; Tonjes, M B; Trzupek, A; Vale, C; van Nieuwenhuizen, G J; Verdier, R; Veres, G I; Wolfs, F L H; Wosiek, B; Wozniak, K; Wuosmaa, A H; Wyslouch, B; Zhang, J

    2004-01-01

    Results on charged particle production in p+p, d+Au and Au+Au collisions at RHIC energies (sqrt(s_NN) = 19.6 to 200 GeV) are presented. The data exhibit remarkable, and simple, scaling behaviors, the most prominent of which are discussed.

  12. Quarkonia and Open Heavy Flavour Production in pp collisions with the ATLAS experiment

    CERN Document Server

    Bini, Cesare; The ATLAS collaboration

    2016-01-01

    The most recent results on heavy flavor production in pp collisions at LHC of the ATLAS experiment are presented. Results on charmonium production and open charm and beauty are compared to theoretical predictions. A search for bottomonium exotic states is also described.

  13. PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion.

    Science.gov (United States)

    Ma, Xianjue; Lu, Jin-Yu; Dong, Yongli; Li, Daming; Malagon, Juan N; Xu, Tian

    2017-06-27

    RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this, we performed a genetic screen in Drosophila, aiming to find mutations that cooperate with oncogenic Ras (Ras(V12)) to induce tumor overgrowth and invasion. We identified fiery mountain (fmt), a regulatory subunit of the protein phosphatase 6 (PP6) complex, as a tumor suppressor that synergizes with Ras(V12) to drive c-Jun N-terminal kinase (JNK)-dependent tumor growth and invasiveness. We show that Fmt negatively regulates JNK upstream of dTAK1. We further demonstrate that disruption of PpV, the catalytic subunit of PP6, mimics fmt loss-of-function-induced tumorigenesis. Finally, Fmt synergizes with PpV to inhibit JNK-dependent tumor progression. Our data here further highlight the power of Drosophila as a model system to unravel molecular mechanisms that may be relevant to human cancer biology. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  14. PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion

    Directory of Open Access Journals (Sweden)

    Xianjue Ma

    2017-06-01

    Full Text Available RAS genes are frequently mutated in cancers, yet an effective treatment has not been developed, partly because of an incomplete understanding of signaling within Ras-related tumors. To address this, we performed a genetic screen in Drosophila, aiming to find mutations that cooperate with oncogenic Ras (RasV12 to induce tumor overgrowth and invasion. We identified fiery mountain (fmt, a regulatory subunit of the protein phosphatase 6 (PP6 complex, as a tumor suppressor that synergizes with RasV12 to drive c-Jun N-terminal kinase (JNK-dependent tumor growth and invasiveness. We show that Fmt negatively regulates JNK upstream of dTAK1. We further demonstrate that disruption of PpV, the catalytic subunit of PP6, mimics fmt loss-of-function-induced tumorigenesis. Finally, Fmt synergizes with PpV to inhibit JNK-dependent tumor progression. Our data here further highlight the power of Drosophila as a model system to unravel molecular mechanisms that may be relevant to human cancer biology.

  15. J/psi polarization in pp collisions at sqrt(s)=7 TeV

    DEFF Research Database (Denmark)

    ALICE Collaboration, The; Abelev, B.; Abrahantes Quintana, A.

    2012-01-01

    The ALICE Collaboration has studied J/psi production in pp collisions at sqrt(s)=7 TeV at the LHC through its muon pair decay. The polar and azimuthal angle distributions of the decay muons were measured, and results on the J/psi polarization parameters lambda_theta and lambda_phi were obtained. ...

  16. Midrapidity inclusive densities in high energy pp collisions in additive quark model

    Science.gov (United States)

    Shabelski, Yu. M.; Shuvaev, A. G.

    2016-08-01

    High energy (CERN SPS and LHC) inelastic pp (pbar{p}) scattering is treated in the framework of the additive quark model together with Pomeron exchange theory. We extract the midrapidity inclusive density of the charged secondaries produced in a single quark-quark collision and investigate its energy dependence. Predictions for the π p collisions are presented.

  17. (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity.

    Science.gov (United States)

    Maisonneuve, Etienne; Castro-Camargo, Manuela; Gerdes, Kenn

    2013-08-29

    Persistence refers to the phenomenon in which isogenic populations of antibiotic-sensitive bacteria produce rare cells that transiently become multidrug tolerant. Whether slow growth in a rare subset of cells underlies the persistence phenotype has not be examined in wild-type bacteria. Here, we show that an exponentially growing population of wild-type Escherichia coli cells produces rare cells that stochastically switch into slow growth, that the slow-growing cells are multidrug tolerant, and that they are able to resuscitate. The persistence phenotype depends hierarchically on the signaling nucleotide (p)ppGpp, Lon protease, inorganic polyphosphate, and toxin-antitoxins. We show that the level of (p)ppGpp varies stochastically in a population of exponentially growing cells and that the high (p)ppGpp level in rare cells induces slow growth and persistence. (p)ppGpp triggers slow growth by activating toxin-antitoxin loci through a regulatory cascade depending on inorganic polyphosphate and Lon protease.

  18. Measurement of the s dependence of jet production at the CERN pp collider

    DEFF Research Database (Denmark)

    Appel, J.A.; Bagnaia, P.; Banner, M.

    1985-01-01

    The production of very large transverse momentum (pT) hadron jets has been measured in the UA2 experiment at the CERN pp Collider for s=630 GeV. The inclusive jet production cross sections exhibit a pT-dependent increase with respect to the s=546 GeV data from previous Collider runs. This increas...

  19. Investigation on the Cellular Structure and Mechanical Properties of SGF/PP Foam Composites Modified with PP-g-MAH%PP-g-MAH改性SGF/PP泡沫复合材料的结构与力学性能研究

    Institute of Scientific and Technical Information of China (English)

    杨继年; 李子全

    2012-01-01

    The short glass fiber (SGF)/polypropylene (PP) foam composites modified with maleic anhydride grafted PP (PP-g-MAH) were prepared via post-foaming process in designed dies. The influence of PP-g-MAH content on the cellular morphologies, microstructures and mechanical properties of composites were investigated. The results show that the outstanding improvement in foaming effect is realized by the addition of PP-g-MAH with a 35% reduction for average cell size and nearly four-fold increase in cell density. The compatibilities between SGF and PP are improved and their interfacial adhesion is enhanced significantly by the surface pretreatment of coupling agent as well as PP-g-MAH. The flexural strength of SGF/PP foam composites is increased first and then decreased. However, the impact strength exhibits the trend of rapid increasing and then moderating with the increase of PP-g-MAH.%采用型内二次发泡工艺制备了马来酸酐接枝聚丙烯(PP-g-MAH)共混改性短玻璃纤维(SGF)/聚丙烯(PP)泡沫复合材料,考察了PP-g-MAH的含量对复合材料的泡孔形貌、微观结构和力学性能的影响.结果表明:PP-g-MAH的引入改善了泡沫体的发泡效果,平均孔径减小了约35%,泡孔密度提高近4倍且分布均匀;偶联剂的表面包覆和PP-g-MAH的共同作用改善了SGF与PP的相容性,显著增强了两者的界面结合;随SGF含量增加,SGF/PP泡沫复合材料的抗弯强度先增大后减小,而冲击强度则呈现先急剧增加而后趋缓的变化趋势.

  20. Direct and Indirect Targeting of PP2A by Conserved Bacterial Type-III Effector Proteins.

    Directory of Open Access Journals (Sweden)

    Lin Jin

    2016-05-01

    Full Text Available Bacterial AvrE-family Type-III effector proteins (T3Es contribute significantly to the virulence of plant-pathogenic species of Pseudomonas, Pantoea, Ralstonia, Erwinia, Dickeya and Pectobacterium, with hosts ranging from monocots to dicots. However, the mode of action of AvrE-family T3Es remains enigmatic, due in large part to their toxicity when expressed in plant or yeast cells. To search for targets of WtsE, an AvrE-family T3E from the maize pathogen Pantoea stewartii subsp. stewartii, we employed a yeast-two-hybrid screen with non-lethal fragments of WtsE and a synthetic genetic array with full-length WtsE. Together these screens indicate that WtsE targets maize protein phosphatase 2A (PP2A heterotrimeric enzyme complexes via direct interaction with B' regulatory subunits. AvrE1, another AvrE-family T3E from Pseudomonas syringae pv. tomato strain DC3000 (Pto DC3000, associates with specific PP2A B' subunit proteins from its susceptible host Arabidopsis that are homologous to the maize B' subunits shown to interact with WtsE. Additionally, AvrE1 was observed to associate with the WtsE-interacting maize proteins, indicating that PP2A B' subunits are likely conserved targets of AvrE-family T3Es. Notably, the ability of AvrE1 to promote bacterial growth and/or suppress callose deposition was compromised in Arabidopsis plants with mutations of PP2A genes. Also, chemical inhibition of PP2A activity blocked the virulence activity of both WtsE and AvrE1 in planta. The function of HopM1, a Pto DC3000 T3E that is functionally redundant to AvrE1, was also impaired in specific PP2A mutant lines, although no direct interaction with B' subunits was observed. These results indicate that sub-component specific PP2A complexes are targeted by bacterial T3Es, including direct targeting by members of the widely conserved AvrE-family.

  1. PP2A: The Achilles Heal in MDS with 5q Deletion

    Directory of Open Access Journals (Sweden)

    David eSallman

    2014-09-01

    Full Text Available Myelodysplastic syndromes (MDS represent a hematologically diverse group of myeloid neoplasms, however, one subtype characterized by an isolated deletion of chromosome 5q (del(5q is pathologically and clinically distinct. Patients with del(5q MDS share biological features that account for the profound hypoplastic anemia and unique sensitivity to treatment with lenalidomide. Ineffective erythropoiesis in del(5q MDS arises from allelic deletion of the ribosomal processing S-14 (RPS14 gene, which leads to MDM2 sequestration with consequent p53 activation and erythroid cell death. Since its approval in 2005, lenalidomide has changed the natural course of the disease. Patients who achieve transfusion independence and/or a cytogenetic response with lenalidomide have a decreased risk of progression to AML and an improved overall survival compared to non-responders. Elucidation of the mechanisms of action of lenalidomide in del(5q MDS has advanced therapeutic strategies for this disease. The selective cytotoxicity of lenalidomide in del(5q clones derives from inhibition of a haplodeficient phosphatase whose catalytic domain is encoded within the common deleted region on chromosome 5q, i.e., protein phosphatase 2A (PP2Acα. PP2A is a highly conserved, dual specificity phosphatase that plays an essential role in regulation of the G2/M checkpoint. Inhibition of PP2Acα results in cell cycle arrest and apoptosis in del(5q cells. Targeted knockdown of PP2Acα using siRNA is sufficient to sensitize non-del(5q clones to lenalidomide. Through its inhibitory effect on PP2A, lenalidomide stabilizes MDM2 to restore p53 degradation in erythroid precursors, with subsequent arrest in G2/M. Unfortunately, the majority of patients with del(5q MDS develop resistance to lenalidomide over time associated with PP2Acα overexpression. Targeted inhibition of PP2A with a more potent inhibitor has emerged as an attractive therapeutic approach for patients with del(5q MDS.

  2. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.

    Science.gov (United States)

    Chattopadhyay, Debasish; Swingle, Mark R; Salter, Edward A; Wood, Eric; D'Arcy, Brandon; Zivanov, Catherine; Abney, Kevin; Musiyenko, Alla; Rusin, Scott F; Kettenbach, Arminja; Yet, Larry; Schroeder, Chad E; Golden, Jennifer E; Dunham, Wade H; Gingras, Anne-Claude; Banerjee, Surajit; Forbes, David; Wierzbicki, Andrzej; Honkanen, Richard E

    2016-06-01

    Cantharidin is a natural toxin and an active constituent in a traditional Chinese medicine used to treat tumors. Cantharidin acts as a semi-selective inhibitor of PPP-family ser/thr protein phosphatases. Despite sharing a common catalytic mechanism and marked structural similarity with PP1C, PP2AC and PP5C, human PP4C was found to be insensitive to the inhibitory activity of cantharidin. To explore the molecular basis for this selectivity, we synthesized and tested novel C5/C6-derivatives designed from quantum-based modeling of the interactions revealed in the co-crystal structures of PP5C in complex with cantharidin. Structure-activity relationship studies and analysis of high-resolution (1.25Å) PP5C-inhibitor co-crystal structures reveal close contacts between the inhibitor bridgehead oxygen and both a catalytic metal ion and a non-catalytic phenylalanine residue, the latter of which is substituted by tryptophan in PP4C. Quantum chemistry calculations predicted that steric clashes with the bulkier tryptophan side chain in PP4C would force all cantharidin-based inhibitors into an unfavorable binding mode, disrupting the strong coordination of active site metal ions observed in the PP5C co-crystal structures, thereby rendering PP4C insensitive to the inhibitors. This prediction was confirmed by inhibition studies employing native human PP4C. Mutation of PP5C (F446W) and PP1C (F257W), to mimic the PP4C active site, resulted in markedly suppressed sensitivity to cantharidin. These observations provide insight into the structural basis for the natural selectivity of cantharidin and provide an avenue for PP4C deselection. The novel crystal structures also provide insight into interactions that provide increased selectivity of the C5/C6 modifications for PP5C versus other PPP-family phosphatases.

  3. Effects of guanosine 3',5'-bisdiphosphate (ppGpp) on rate of transcription elongation in isoleucine-starved Escherichia coli

    DEFF Research Database (Denmark)

    Vogel, Ulla; Jensen, Kaj Frank

    1994-01-01

    (approximately 50%) in rel+ strains that accumulated high concentrations of guanosine 3',5'-bisdiphosphate (ppGpp) and increased (approximately 15%) the relA mutant whose ppGpp pool decayed during starvation. These results show that ppGpp inhibits mRNA chain elongation in vivo. However, stable RNA chain...... elongation appeared unaffected by ppGpp pool size and was twice as fast as mRNA chain elongation in exponentially growing cells....

  4. Nazca-South America Subduction Zone Reflectivity from P'P' Precursors

    Science.gov (United States)

    Gu, Y. J.; Schultz, R.

    2012-12-01

    Much of what is known about mantle owes to the interpretation of its reflectivity structure. On the global scale mantle stratifications have been attributed to mineralogical phase changes of olivine; two widely observed examples are the 410 and 660 km discontinuities. Among the various seismological tools, results from longer-period SS/PP precursors and high frequency receiver functions are routinely compared to increase the confidence of the recovered mantle stratifications. The former are lower frequency approaches with complex Fresnel zones, while constraints on receiver distribution hinder analysis in oceanic regions for the latter. P'P' precursors are a promising high frequency alternative, capable of resolving small-scale structures (resolution of ~5 km vertically, 200 km laterally) in the mantle, owing to its short-period nature (~1Hz), shallow angle of incidence and nearly symmetric Fresnel zone. However, P'P' precursors are known for several complications: phase triplication (PKiKPPKiKP, PKIKPPKIKP, PKPPKPab and PKPPKPbc) and the maximum-phase Fresnel zones result in strong scattering and asymmetric arrivals. Much of these concerns are alleviated through revamped processing techniques involving stacking, deconvolution, Radon transform and migration. We utilize P'P' precursors to constrain the mantle structure and layering beneath the Nazca-South America subduction zone. Our migration profiles reveal both olivine (e.g., 410, 520, 660) and garnet related transitions in the mantle, with constraints on the sharpness of these transitions. Observations of a depressed 660 are attributed to thermal variations, showing the spatial extent of the impinging Nazca slab. Prominent 520 arrivals near subducted slab material suggest this transition is sharpened to a thickness resonant with P'P' (~10km). The possibility of chemical heterogeneity is evidenced near the top of the mantle transition zone through complicated 410 amplitudes. The existence, depth, sharpness and

  5. Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation

    Directory of Open Access Journals (Sweden)

    Cui-cui Yang

    2013-01-01

    Full Text Available Aim. The aim of the present study was to investigate the effect of cornel iridoid glycoside (CIG on tau hyperphosphorylation induced by wortmannin (WT and GF-109203X (GFX and the underlying mechanisms. Methods. Human neuroblastoma SK-N-SH cells were preincubated with CIG (50, 100, and 200 µg/ml, resp. for 24 h and then exposed to 10 µM WT and 10 µM GFX for 3 h after washing out CIG. Immunohistochemistry was used to observe the microtubular cytoskeleton of the cultured cells. Western blotting was used to measure the phosphorylation level of tau protein, glycogen synthase kinase 3β (GSK-3β, and protein phosphatase 2A (PP2A. The activity of PP2A was detected by a biochemical assay. Results. Preincubation of CIG significantly attenuated the WT/GFX-induced tau hyperphosphorylation at the sites of Thr205, Thr212, Ser214, Thr217, Ser396, and PHF-1 and improved the damage of morphology and microtubular cytoskeleton of the cells. CIG did not prevent the decrease in p-AKT-ser473 and p-GSK-3β-ser9 induced by WT/GFX. However, CIG significantly elevated the activity of PP2A by reducing the demethylation of PP2A catalytic subunit (PP2Ac at Leu309 and the ratio of PME-1/LCMT in the WT/GFX-treated cells. The results suggest that CIG may be beneficial to the treatment of AD.

  6. Stability and assembly in vitro of bacteriophage PP7 virus-like particles

    Directory of Open Access Journals (Sweden)

    Peabody David S

    2007-11-01

    Full Text Available Abstract Background The stability of a virus-like particle (VLP is an important consideration for its use in nanobiotechnology. The icosahedral capsid of the RNA bacteriophage PP7 is cross-linked by disulfide bonds between coat protein dimers at its 5-fold and quasi-6-fold symmetry axes. This work determined the effects of these disulfides on the VLP's thermal stability. Results Measurements of the thermal denaturation behavior of PP7 VLPs in the presence and absence of a reducing agent show that disulfide cross-links substantially stabilize them against thermal denaturation. Although dimers in the capsid are linked to one another by disulfides, the two subunits of dimers themselves are held together only by non-covalent interactions. In an effort to confer even greater stability a new cross-link was introduced by genetically fusing two coat protein monomers, thus producing a "single-chain dimer" that assembles normally into a completely cross-linked VLP. However, subunit fusion failed to increase the thermal stability of the particles, even though it stabilized the isolated dimer. As a step toward gaining control of the internal composition of the capsid, conditions that promote the assembly of PP7 coat protein dimers into virus-like particles in vitro were established. Conclusion The presence of inter-dimer disulfide bonds greatly stabilizes the PP7 virus-like particle against thermal denaturation. Covalently cross-linking the subunits of the dimers themselves by genetically fusing them through a dipeptide linker sequence, offers no further stabilization of the VLP, although it does stabilize the dimer. PP7 capsids readily assemble in vitro in a reaction that requires RNA.

  7. GF增强母粒对微发泡PP/GF复合材料力学性能的影响%Effect of GF Reinforced Masterbatch on Mechanical Performances of Microcellur Foam PP/GF Composites

    Institute of Scientific and Technical Information of China (English)

    何海; 邱启航; 何力; 龚维; 张纯

    2013-01-01

    采用熔融共混挤出的方法制备了A、B两种玻璃纤维(GF)增强母粒.将两种母粒与自制发泡母粒、助剂母粒按一定比例混合,在二次开模条件下制备了PP/GF复合微发泡材料,研究了两种GF增强母粒对微发泡PP/GF复合材料力学性能的影响,同时还探讨了结晶行为对微发泡复合材料力学性能的影响.结果表明:A母粒制备的微发泡PP/GF复合材料性能优于B母粒,在GF含量为30%时,A母粒制备的微发泡复合材料的拉伸强度和冲击强度分别为55.72 MPa、7.58 k J/m2,与B母粒制备的发泡PP/GF复合材料比较,其拉伸强度和冲击强度分别提高了9.97 MPa、1.1 kJ/m2.%Two kinds of GF reinforced PP masterbatch were prepared through extrusion melt blending method.Mixing homemade foaming masterbatch,additives masterbatch and two kinds of GF masterbatch (A and B)according to a cirtain proportion,the micro-foamed PP/GF composite was prepared under the twice-mold-opening condition.The effects of GF reinforced PP masterbatch and the crystallization behavior on the mechanical performances of micro-foamed PP/GF composite were researched.The results indicate that:the mechanical performance of PP/GF microcellular foam material prepared by A masterbatch is better than that of PP/GF microcellular foam material prepared by B masterbatch.The tensile strength and impact toughness of the foamed PP/GF contained with A masterbatch are respectively 55.72 MPa and 7.58 k J/m2,compared to PP/GF microcellular foam material contained with B masterbatch,the tensile strength and impact toughness increase by respectively 9.97 MPa and 1.1 k J/m2.

  8. PREFERENTIAL INTERCALATION BEHAVIOR OF CLAY AND ITS EFFECT ON THE THERMAL DEGRADATION IN IMMISCIBLE PP/PS BLENDS

    Institute of Scientific and Technical Information of China (English)

    Yan Zhu; Hai-yun Ma; Li-fang Tong; Zheng-ping Fang

    2008-01-01

    The typical immiscible PP/PS blend based clay nanocomposites were prepared via melt blending.The dispersion of clay was determined by X-ray diffraction (XRD) and transmission electron microscopy (TEM).Thermal stability and dynamic mechanical properties were measured by thermogravimetrical analysis (TGA) and dynamic mechanical analysis (DMA),respectively.Preferential intercalation behavior of clay in PP/PS blends was found.The dispersion of clay is significantly influenced by the polarity of PP and PS,meanwhile the location of clay can be controlled by the alternation of the polarity of PP and PS through chemical modification.The clay migrates from PS phase to PP phase with the improvement of the polarity of PP.However,when the PS is sulfonated,clay migrates back to the dispersed PS phase again.The dispersion and location of clay have profound influence on the thermal and dynamic mechanical behavior of PP/PS blends.The better the dispersion of clay in either continuous phase or disperse phase,the higher the thermal stability of the blends.Besides,samples with clay located in the continuous phase can display the best strengthening effect.

  9. 6S RNA regulation of relA alters ppGpp levels in early stationary phase.

    Science.gov (United States)

    Cavanagh, Amy T; Chandrangsu, Pete; Wassarman, Karen M

    2010-12-01

    6S RNA is a small, non-coding RNA that interacts directly with σ(70)-RNA polymerase and regulates transcription at many σ(70)-dependent promoters. Here, we demonstrate that 6S RNA regulates transcription of relA, which encodes a ppGpp synthase. The 6S RNA-dependent regulation of relA expression results in increased ppGpp levels during early stationary phase in cells lacking 6S RNA. These changes in ppGpp levels, although modest, are sufficient to result in altered regulation of transcription from σ(70)-dependent promoters sensitive to ppGpp, including those promoting expression of genes involved in amino acid biosynthesis and rRNA. These data place 6S RNA as another player in maintaining appropriate gene expression as cells transition into stationary phase. Independent of this ppGpp-mediated 6S RNA-dependent regulation, we also demonstrate that in later stationary phase, 6S RNA continues to downregulate transcription in general, and specifically at a subset of the amino acid promoters, but through a mechanism that is independent of ppGpp and which we hypothesize is through direct regulation. In addition, 6S RNA-dependent regulation of σ(S) activity is not mediated through observed changes in ppGpp levels. We suggest a role for 6S RNA in modulating transcription of several global regulators directly, including relA, to downregulate expression of key pathways in response to changing environmental conditions.

  10. I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis.

    Science.gov (United States)

    Liu, Gong-Ping; Wei, Wei; Zhou, Xin; Zhang, Yao; Shi, Hai-Hong; Yin, Jun; Yao, Xiu-Qing; Peng, Cai-Xia; Hu, Juan; Wang, Qun; Li, Hong-Lian; Wang, Jian-Zhi

    2012-02-01

    A chronic neuron loss is the cardinal pathology in Alzheimer disease (AD), but it is still not understood why most neurons in AD brain do not accomplish apoptosis even though they are actually exposed to an environment with enriched proapoptotic factors. Protein phosphatase-2A inhibitor-2 (I(2)(PP2A)), an endogenous PP2A inhibitor, is significantly increased in AD brain, but the role of I(2)(PP2A) in AD-like neuron loss is elusive. Here, we show that I(2)(PP2A) regulates p53 and Akt correlatively. The mechanisms involve activated transcription and p38 MAPK activities. More importantly, we demonstrate that the simultaneous activation of Akt induced by I(2)(PP2A) counteracts the hyperactivated p53-induced cell apoptosis. Furthermore, I(2)(PP2A), p53 and Akt are all elevated in the brain of mouse model and AD patients. Our results suggest that the increased I(2)(PP2A) may trigger apoptosis by p53 upregulation, but due to simultaneous activation of Akt, the neurons are aborted from the apoptotic pathway. This finding contributes to the understanding of why most neurons in AD brain do not undergo apoptosis.

  11. Overexpression of HDAC1 induces cellular senescence by Sp1/PP2A/pRb pathway

    Energy Technology Data Exchange (ETDEWEB)

    Chuang, Jian-Ying [Department of Pharmacology, National Cheng-Kung University, Tainan 701, Taiwan (China); Hung, Jan-Jong, E-mail: petehung@mail.ncku.edu.tw [Department of Pharmacology, National Cheng-Kung University, Tainan 701, Taiwan (China); Institute of Bioinformatics and Biosignal Transduction, National Cheng-Kung University, Tainan 701, Taiwan (China)

    2011-04-15

    Highlights: {yields} Overexpression of HDAC1 induces Sp1 deacetylation and raises Sp1/p300 complex formation to bind to PP2Ac promoter. {yields} Overexpression of HDAC1 strongly inhibits the phosphorylation of pRb through up-regulation of PP2A. {yields} Overexpressed HDAC1 restrains cell proliferaction and induces cell senescence though a novel Sp1/PP2A/pRb pathway. -- Abstract: Senescence is associated with decreased activities of DNA replication, protein synthesis, and cellular division, which can result in deterioration of cellular functions. Herein, we report that the growth and division of tumor cells were significantly repressed by overexpression of histone deacetylase (HDAC) 1 with the Tet-off induced system or transient transfection. In addition, HDAC1 overexpression led to senescence through both an accumulation of hypophosphorylated active retinoblastoma protein (pRb) and an increase in the protein level of protein phosphatase 2A catalytic subunit (PP2Ac). HDAC1 overexpression also increased the level of Sp1 deacetylation and elevated the interaction between Sp1 and p300, and subsequently that Sp1/p300 complex bound to the promoter of PP2Ac, thus leading to induction of PP2Ac expression. Similar results were obtained in the HDAC1-Tet-off stable clone. Taken together, these results indicate that HDAC1 overexpression restrained cell proliferation and induced premature senescence in cervical cancer cells through a novel Sp1/PP2A/pRb pathway.

  12. The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex.

    Science.gov (United States)

    Zuo, Yuhong; Wang, Yeming; Steitz, Thomas A

    2013-05-01

    Guanosine tetraphosphate (ppGpp) is an alarmone that enables bacteria to adapt to their environment. It has been known for years that ppGpp acts directly on RNA polymerase (RNAP) to alter the rate of transcription, but its exact target site is still under debate. Here we report a crystal structure of Escherichia coli RNAP holoenzyme in complex with ppGpp at 4.5 Å resolution. The structure reveals that ppGpp binds at an interface between the shelf and core modules on the outer surface of RNAP, away from the catalytic center and the nucleic acid binding path. Bound ppGpp connects these two pivotal modules that may restrain the opening of the RNAP cleft. A detailed mechanism of action of ppGpp is proposed in which ppGpp prevents the closure of the active center that is induced by the binding of NTP, which could slow down nucleotide addition cycles and destabilize the initial transcription complexes.

  13. Mir-338-3p Mediates Tnf-A-Induced Hepatic Insulin Resistance by Targeting PP4r1 to Regulate PP4 Expression.

    Science.gov (United States)

    Dou, Lin; Wang, Shuyue; Sun, Libo; Huang, Xiuqing; Zhang, Yang; Shen, Tao; Guo, Jun; Man, Yong; Tang, Weiqing; Li, Jian

    2017-01-01

    Insulin resistance is a critical factor contributing to the pathogenesis of type 2 diabetes and other metabolic diseases. Recent studies have indicated that miR-338-3p plays an important role in cancer. Here, we investigated whether miR-338-3p mediates tumour necrosis factor-α (TNF-α)-induced hepatic insulin resistance. The activation of the insulin signalling pathway and the level of glycogenesis were examined in the livers of the db/db and high fat diet (HFD)-fed mice and in HEP1-6 cells transfected with miR-338-3p mimic or inhibitor. Computational prediction of microRNA target, luciferase assay and Western blot were used to assess the miR-338-3p target. Chromatin immunoprecipitation (ChIP) assay was used to determine the transcriptional regulator of miR-338-3p. miR-338-3p was down-regulated in the livers of the db/db, HFD-fed and TNF-α-treated C57BL/6J mice, as well as in mouse HEP1-6 hepatocytes treated with TNF-α. Importantly the down-regulation of miR-338-3p induced insulin resistance, as indicated by impaired glucose tolerance and insulin tolerance. Further research showed that the down-regulated miR-338-3p resulted in the impaired AKT/ glycogen synthase kinase 3 beta (GSl·Gβ) signalling pathway and glycogen synthesis. In contrast, hepatic over-expression of miR-338-3p rescued the TNF-α-induced insulin resistance. Moreover, protein phosphatase 4 regulator subunit 1 (PP4R1) was identified as a direct target of miR-338-3p that mediated hepatic insulin signalling by regulating protein phosphatase 4 (PP4). Finally we identified hepatic nuclear factor 4 alpha (HNF-4α) as the transcriptional regulator of miRNA-338-3p. Our studies provide novel insight into the critical role and molecular mechanism by which miR-338-3p is involved in TNF-α-induced hepatic insulin resistance. miR-338-3p might mediate TNF-α-induced hepatic insulin resistance by targeting PP4R1 to regulate PP4 expression. © 2017 The Author(s). Published by S. Karger AG, Basel.

  14. The importance of {eta} exchange in the pp{yields}pp{eta} process up to T{sub lab}=4.5 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Ceci, Sasa; Svarc, Alfred; Zauner, Branimir [Ruder Boskovic Institute, Bijenicka Cesta 54, 10000 Zagreb (Croatia)

    2006-06-15

    The new and improved treatment of {eta}-meson exchange diagrams turns out to be essential in order to fully describe both total cross-sections and, in particular, the challenging pp invariant mass distributions. Contrary to other approaches, the {eta}-meson contribution in our model is comparable with the leading {pi}-meson exchange term, and using the phenomenological final state interaction we have no need to include other mesons, like {rho} and {omega}, in order to obtain good agreement with experiment.

  15. (p)ppGpp, a Small Nucleotide Regulator, Directs the Metabolic Fate of Glucose in Vibrio cholerae.

    Science.gov (United States)

    Oh, Young Taek; Lee, Kang-Mu; Bari, Wasimul; Raskin, David M; Yoon, Sang Sun

    2015-05-22

    When V. cholerae encounters nutritional stress, it activates (p)ppGpp-mediated stringent response. The genes relA and relV are involved in the production of (p)ppGpp, whereas the spoT gene encodes an enzyme that hydrolyzes it. Herein, we show that the bacterial capability to produce (p)ppGpp plays an essential role in glucose metabolism. The V. cholerae mutants defective in (p)ppGpp production (i.e. ΔrelAΔrelV and ΔrelAΔrelVΔspoT mutants) lost their viability because of uncontrolled production of organic acids, when grown with extra glucose. In contrast, the ΔrelAΔspoT mutant, a (p)ppGpp overproducer strain, exhibited better growth in the presence of the same glucose concentration. An RNA sequencing analysis demonstrated that transcriptions of genes consisting of an operon for acetoin biosynthesis were markedly elevated in N16961, a seventh pandemic O1 strain, but not in its (p)ppGpp(0) mutant during glucose-stimulated growth. Transposon insertion in acetoin biosynthesis gene cluster resulted in glucose-induced loss of viability of the ΔrelAΔspoT mutant, further suggesting the crucial role of acetoin production in balanced growth under glucose-rich environments. Additional deletion of the aphA gene, encoding a negative regulator for acetoin production, failed to rescue the (p)ppGpp(0) mutant from the defective glucose-mediated growth, suggesting that (p)ppGpp-mediated acetoin production occurs independent of the presence of AphA. Overall, our results reveal that (p)ppGpp, in addition to its well known role as a stringent response mediator, positively regulates acetoin production that contributes to the successful glucose metabolism and consequently the proliferation of V. cholerae cells under a glucose-rich environment, a condition that may mimic the human intestine.

  16. 6S RNA regulation of relA alters ppGpp levels in early stationary phase

    OpenAIRE

    Cavanagh, Amy T.; Chandrangsu, Pete; Wassarman, Karen M.

    2010-01-01

    6S RNA is a small, non-coding RNA that interacts directly with ? 70-RNA polymerase and regulates transcription at many ? 70-dependent promoters. Here, we demonstrate that 6S RNA regulates transcription of relA, which encodes a ppGpp synthase. The 6S RNA-dependent regulation of relA expression results in increased ppGpp levels during early stationary phase in cells lacking 6S RNA. These changes in ppGpp levels, although modest, are sufficient to result in altered regulation of transcription fr...

  17. Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.

    Science.gov (United States)

    Bergman, Jessica M; Hammarlöf, Disa L; Hughes, Diarmaid

    2014-01-01

    Transcription and translation of mRNA's are coordinated processes in bacteria. We have previously shown that a mutant form of EF-Tu (Gln125Arg) in Salmonella Typhimurium with a reduced affinity for aa-tRNA, causes ribosome pausing, resulting in an increased rate of RNase E-mediated mRNA cleavage, causing extremely slow growth, even on rich medium. The slow growth phenotype is reversed by mutations that reduce RNase E activity. Here we asked whether the slow growth phenotype could be reversed by overexpression of a wild-type gene. We identified spoT (encoding ppGpp synthetase/hydrolase) as a gene that partially reversed the slow growth rate when overexpressed. We found that the slow-growing mutant had an abnormally high basal level of ppGpp that was reduced when spoT was overexpressed. Inactivating relA (encoding the ribosome-associated ppGpp synthetase) also reduced ppGpp levels and significantly increased growth rate. Because RelA responds specifically to deacylated tRNA in the ribosomal A-site this suggested that the tuf mutant had an increased level of deacylated tRNA relative to the wild-type. To test this hypothesis we measured the relative acylation levels of 4 families of tRNAs and found that proline isoacceptors were acylated at a lower level in the mutant strain relative to the wild-type. In addition, the level of the proS tRNA synthetase mRNA was significantly lower in the mutant strain. We suggest that an increased level of deacylated tRNA in the mutant strain stimulates RelA-mediated ppGpp production, causing changes in transcription pattern that are inappropriate for rich media conditions, and contributing to slow growth rate. Reducing ppGpp levels, by altering the activity of either SpoT or RelA, removes one cause of the slow growth and reveals the interconnectedness of intracellular regulatory mechanisms.

  18. Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.

    Directory of Open Access Journals (Sweden)

    Jessica M Bergman

    Full Text Available Transcription and translation of mRNA's are coordinated processes in bacteria. We have previously shown that a mutant form of EF-Tu (Gln125Arg in Salmonella Typhimurium with a reduced affinity for aa-tRNA, causes ribosome pausing, resulting in an increased rate of RNase E-mediated mRNA cleavage, causing extremely slow growth, even on rich medium. The slow growth phenotype is reversed by mutations that reduce RNase E activity. Here we asked whether the slow growth phenotype could be reversed by overexpression of a wild-type gene. We identified spoT (encoding ppGpp synthetase/hydrolase as a gene that partially reversed the slow growth rate when overexpressed. We found that the slow-growing mutant had an abnormally high basal level of ppGpp that was reduced when spoT was overexpressed. Inactivating relA (encoding the ribosome-associated ppGpp synthetase also reduced ppGpp levels and significantly increased growth rate. Because RelA responds specifically to deacylated tRNA in the ribosomal A-site this suggested that the tuf mutant had an increased level of deacylated tRNA relative to the wild-type. To test this hypothesis we measured the relative acylation levels of 4 families of tRNAs and found that proline isoacceptors were acylated at a lower level in the mutant strain relative to the wild-type. In addition, the level of the proS tRNA synthetase mRNA was significantly lower in the mutant strain. We suggest that an increased level of deacylated tRNA in the mutant strain stimulates RelA-mediated ppGpp production, causing changes in transcription pattern that are inappropriate for rich media conditions, and contributing to slow growth rate. Reducing ppGpp levels, by altering the activity of either SpoT or RelA, removes one cause of the slow growth and reveals the interconnectedness of intracellular regulatory mechanisms.

  19. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit.

    Science.gov (United States)

    Boylan, Joan M; Salomon, Arthur R; Tantravahi, Umadevi; Gruppuso, Philip A

    2015-07-15

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders.

  20. Mechanical properties of reed/basalt fiber-reinforced PP/EVA composite%芦苇/玄武岩纤维增强PP/EVA复合材料 力学性能的研究

    Institute of Scientific and Technical Information of China (English)

    李智佳; 任庆龙; 夏英; 张锋锋; 丛世杰

    2016-01-01

    利用双辊开炼机将芦苇纤维(L)、玄武岩纤维(X)与聚丙烯(PP)、聚醋酸乙烯酯(EVA)进行熔融共混,制备了PP/EVA/L/X复合材料;通过碱处理L,硫酸/硅烷偶联剂联合处理X,得到改性芦苇纤维(AL)和改性玄武岩纤维(SSiX),同样方法制得PP/EVA/AL/SSiX复合材料;研究了2种纤维复配质量比对复合材料力学性能的影响,分析了复合材料的微观结构与形貌.结果表明:当L与X复配质量比为1:5时,PP/EVA/L/X复合材料的综合力学性能较好;与PP/EVA复合材料相比,AL与SSiX质量比为1:5时,PP/EVA/AL/SSiX复合材料的拉伸强度提高了10.67 MPa,弯曲强度提高了11.38 MPa,但冲击强度有所下降,加工流动性也有所下降;PP/EVA/AL/SSiX复合材料的力学性能优于PP/EVA/L/X复合材料.%A polypropylene/polyvinyl acetate/reed/basalt ( PP/EVA/L/X) composite was prepared by melt blending L fiber , X fiber, PP and EVA on a two-roller mill.A modified reed (AL) fiber and a modified basalt (SSiX) fiber were obtained by trea-ting L in a basic solution and X with a sulfuric acid-silane coupling agent .A PP/EVA/AL/SSiX composite was prepared by the same process .The effect of the compound ratio of two fibers on the mechanical properties of the composites was studied .The mi-crostructure and morphology of the composites were analyzed .The results showed that PP/EVA/L/X composite had fairly good comprehensive properties as the mass ratio of L and X was 1:5;as compared with PP/EVA composite , PP/EVA/AL/SSiX com-posite showed an increase of 10.67 MPa in tensile strength and 11.38 MPa in bending strength , but some decrease in impact strength and processing flowability as the mass ratio of AL and SSiX was 1:5;PP/EVA/AL/SSiX composite was better than PP/EVA/L/X composite in the mechanical properties .

  1. PP2A的肿瘤抑制功能及与凋亡因子Noxa的关系%PP2A’s suppressing tumor function and its relationship with apoptosis factor Noxa

    Institute of Scientific and Technical Information of China (English)

    董伟; 田淑君; 魏志; 朱述英; 陈丙春; 王海涛

    2015-01-01

    目的:检测PP2 A及Noxa蛋白在大肠癌癌组织和癌旁组织中的表达,探讨PP2 A、Noxa在大肠癌发生、发展中的作用以及二者的相关性。方法采用免疫组织化学法检测40例大肠癌患者的癌组织(大肠癌组)及癌旁组织(癌旁组) PP2A、Noxa蛋白表达情况,采用TUNEL法检测细胞凋亡情况。结果大肠癌组PP2A与Noxa蛋白阳性表达率(90%、82.5%)明显低于癌旁组(95%、88.1%),P<0.05;大肠癌组PP2A、Noxa蛋白阳性表达在大肠癌组织分化程度、淋巴结转移差异有统计学意义( P<0.05);40例大肠癌组织中PP2A蛋白与Noxa蛋白表达之间呈正相关(r=0.229,P<0.05)。大肠癌癌细胞凋亡指数在癌细胞分化程度、淋巴结转移及临床分期上差异有统计学意义( P<0.05);大肠癌组PP2A、Noxa表达阴性者癌细胞凋亡指数均明显低于表达阳性者( P<0.05)。结论 PP2 A、Noxa蛋白可能相互协同,在结直肠癌的发生、发展过程中发挥抑制作用。%Objective To detect PP2 A and Noxa expression in colorectal carcinoma tissues and paracarcinoma tissues , and to explore the function and the correlation between PP 2A and Noxa in colorectal carcinoma .Methods PP2 A and Noxa protein in 40 colorectal carcinoma tissues and 40 paracancerous tissues were detected by immunohistochemical technique .The cell apop-tosis was detected by TUNEL .Results The positive expression of PP2A protein in colorectal cancer tissues was 90%, which was significantly lower than that of paracancerous tissues (95%)(P<0.05 );Noxa protein positive expression was 82.5% in colorectal cancer tissues vs 88.1%in paracarcinoma tissues (P<0.05).The rates of PP2A, Noxa protein expression was associated with the tumor differentiation , lymph node metastasis(P<0.05).Expression of PP2A protein and Noxa protein in 40 cases of colorectal carcinomas tissues showed a positivelinear correlation (r =0.229,P <0

  2. Effects of PP333 on the Ornamental Effect of Potted Pelargonium odoratissmum%PP333对盆栽蚊净香草观赏效果的影响

    Institute of Scientific and Technical Information of China (English)

    王彬; 郑伟; 李兴忠

    2005-01-01

    为了解PP333对盆栽蚊净香草观赏效果的影响,采用不同浓度的PP333对盆栽蚊净香草进行了盆土浇施和叶面喷施处理,结果表明,盆土浇施50~200mg/L,叶面喷施250~500mg/L的PP333能有效地提高盆栽蚊净香昌的观赏效果,而盆土浇施400mg/L以上,叶面喷施1000mg/L以上的PP333会造成不同程度的药害.在适宜的浓度下,盆土浇施效果优于叶面喷施.

  3. Study on thermal oxidative stability of PP/EPDM blends%PP/EPDM共混物热氧稳定性研究

    Institute of Scientific and Technical Information of China (English)

    吴小兵; 刘小林; 杨其; 胡晓娟; 周俊峰; 高丽彦

    2009-01-01

    通过热氧加速老化的方法研究了不同的EPDM含量和抗氧剂对聚丙烯和三元乙丙橡胶共混物(PP/EPDM)热氧稳定性的影响.通过对老化前后试样的力学性能变化分析,热失重(TG)分析和扫描电镜(SEM)分析,结果表明:在热氧加速老化的初期,PP/EPDM共混物的拉伸强度随着时间的增长呈逐渐上升的趋势;在老化中期,共混物的拉伸强度变化不大;在老化后期,共混物的拉伸强度逐渐下降.在整个老化过程中,断裂伸长率都呈逐渐下降的趋势.而随着EPDM含量的增加,相应共混物的拉伸强度和断裂伸长率的下降减缓;相应共混物的分解温度得到较大的提高;抗氧剂的加入,能进一步提高共混物的热氧稳定性.

  4. PP/Al(OH)3无卤阻燃复合材料的制备及性能%Preparation and Properties of PP/Al(OH)3 Halogen-Free Flame Retardant Composites

    Institute of Scientific and Technical Information of China (English)

    李建; 杨明; 刘擎国

    2016-01-01

    The melt blending method was used to prepare the PP/Al(OH)3 halogen-free flame re-tardant composites with polypropylene(PP)as matrix resin,Al(OH)3 as filler and maleic anhydride-grafted EPDM (EPDM-g-MAH)as compatible agents.Thermal properties,the mechanical properties and flame retardant properties of the composites were investigated.The results show that the addition of Al(OH)3 can improve the thermal stability of PP/Al(OH)3 composites.The tensile strength of PP/Al(OH)3 composites decreases significantly,but the flexural strength and impact strength of PP/Al (OH)3 composites increase first and then decrease with the increasing of the content of Al(OH)3 . When the mass fraction of Al(OH)3 is 30%,Al(OH)3 is an excellent flame-retarded agent in the composites,and the comprehensive performance of PP/Al(OH)3 composites is optimum.%以聚丙烯(PP)为基体,氢氧化铝为无机阻燃填料,马来酸酐接枝三元乙丙橡胶(EPDM-g-MAH)为相容剂,采用熔融共混法制得了PP/Al(OH)3无卤阻燃复合材料,研究了复合材料的热性能、力学性能和阻燃性能。结果表明:Al(OH)3可以提高PP/Al(OH)3复合体系的热稳定性。随着 Al(OH)3含量的增加,PP/Al(OH)3复合材料的拉伸强度显著下降,弯曲强度和冲击强度则先升高后下降。当 Al(OH)3质量分数为30%时,Al(OH)3在复合材料中起到了显著的阻燃作用, PP/Al(OH)3复合材料的综合性能较好。

  5. Observation of a Structure in $pp \\to pp\\gamma\\gamma$ near the $\\pi\\pi$ Threshold and its Possible Interpretation by $\\gamma\\gamma$ Radiation from Chiral Loops in the Mesonic $\\sigma$ Channel

    CERN Document Server

    Bashkanov, M; Calén, H; Cappellaro, F; Clement, H; Demiroers, L; Doroshkevich, E; Ekström, C; Fransson, K; Greiff, J; Gustafsson, L; Höistad, Bo; Ivanov, G; Jacewicz, M; Jiganov, E; Johansson, T; Kaskulov, M M; Keleta, S; Koch, I; Kullander, Sven; Kupsc, A; Kuznetsov, A; Marciniewski, P; Meier, R; Morosov, B; Oelert, W; Pauly, C; Petukhov, Yu P; Povtorejko, A; Ruber, Roger J M Y; Scobel, W; Shwartz, B; Skorodko, T Yu; Sopov, V; Stepaniak, J; Chernyshov, V; Thörngren-Engblom, P; Tikhomirov, V; Turowiecki, A; Wagner, G J; Wiedner, U; Wolke, M; Yamamoto, A; Zabierowski, J; Zlomanczuk, Yu

    2004-01-01

    The $pp \\to pp\\gamma\\gamma$ reaction has been measured at CELSIUS using the WASA $4\\pi$-detector with hydrogen pellet target. At $T_p = 1.20$ and 1.36 GeV, where most of the statistics has been accumulated, the $\\gamma\\gamma$ invariant mass spectrum exhibits a narrow structure around the $\\pi\\pi$ threshold, which possibly may be associated with two-photon radiation of $\\pi^+\\pi^-$ loops in the mesonic $\\sigma$ channel.

  6. Mechanical, thermal, rheological and morphological behaviour of irradiated PP/HA composites

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, C. [Universidad de Oriente, Nucleo de Anzoategui, Escuela de Ingenieria y Ciencias Aplicadas, Depto de Ingenieria Quimica, Puerto la Cruz (Venezuela); Albano, C. [Centro de Quimica, Laboratorio de Polimeros, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas 1020A (Venezuela) and Universidad Central de Venezuela, Facultad de Ingenieria, Escuela de Ingenieria Quimica, Caracas 1041A (Venezuela)]. E-mail: calbano@ivic.ve; Karam, A. [Centro de Quimica, Laboratorio de Polimeros, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas 1020A (Venezuela)]. E-mail: akaram@quimica.ivic.ve; Dominguez, N. [Centro de Quimica, Laboratorio de Polimeros, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas 1020A (Venezuela); Sanchez, Y. [Centro de Quimica, Laboratorio de Polimeros, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas 1020A (Venezuela); Gonzalez, G. [Centro Tecnologico, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas 1020A (Venezuela)

    2005-07-01

    Hydroxyapatite (HA) reinforced polypropylene (PP) composites are being developed as bone graft materials. In this research, the effect of {gamma} irradiation on mechanical, rheological, thermal and morphological behaviour of PP-HA composites was studied. The melt flow index of polymer increased markedly when it was exposed to radiation. This is indicative of chain scission reaction as the predominant process. During the tensile testing, the composites exhibited brittle behaviour, showing no fluency point. Elongation at break showed a tendency to decrease with the increase in radiation dose while stress at break did not show significant variation with radiation dose. High HA content (>20%) and radiation dose (25 kGy) had significant influence on thermal stability.

  7. Kinetic parameters of the thermal degradation of the PP and nondegraded and degraded HDPE blends

    Energy Technology Data Exchange (ETDEWEB)

    Albano, C.; Freitas, E. [Universidad Central de Venezuela, Caracas (Venezuela)

    1996-12-31

    We study the thermodegradative behavior of PP, of non-degraded and degraded HDPE and their blends, in order to analyze the thermal stability of such materials. Van-Krevelen (V-K), Coats-Redfern (C-R) and Horowitz-Metzger (H-M) integral methods as well as the Freeman-Carroll (F-C) differential one, were used to determine the kinetic parameters. The activation energy (E{sub a}) obtained for the PP mixed with non-degraded HDPE (5 to 50%) is lower than the E{sub a} correspondent to pure polymers and does not depend on the HDPE concentration. Blends of degraded materials, show an approximate value of E{sub a} of 200 kJ/mol for mixtures with concentrations by weight of HDPE up to 20%, but its value decreases drastically with higher concentrations. 11 refs., 2 tabs.

  8. Studies of particle production in pp collisions in the forward region at LHCb

    CERN Document Server

    AUTHOR|(CDS)2072725

    2016-01-01

    The LHCb detector at the LHC has a pseudorapidity coverage $(2 < \\eta < 5)$ which allows it to perform particle production measurements in a kinematic region where QCD models have large uncertainties. Selected analyses on particle production measurements in $pp$ collisions are summarised in these proceedings. The energy flow has been measured separately for different event classes allowing to probe multi-parton interactions at large $\\eta$. The measured prompt hadron ratios are important for hadronisation models, while the $ \\bar {p}/p$ ratio is a good observable to test models of baryon number transport. Charm production has been studied to determine cross-sections and production ratios. All measurements are compared to a variety of theory predictions.

  9. Study of omega-meson production in pp collisions at ANKE

    CERN Document Server

    Barsov, S; Hartmann, M; Hejny, V; Kacharava, A K; Keshelashvili, I; Khoukaz, A; Koptev, V; Kulessa, P; Kulikov, A; Lehmann, I; Leontyev, V; Macharashvili, G; Maeda, Y; Mersmann, T; Merzliakov, S; Mikirtytchyants, S; Mussgiller, A; Oellers, D; Ohm, H; Rathmann, F; Schleichert, R; Seyfarth, H; Ströher, H; Trusov, S; Valdau, Y; Wüstner, P; Wilkin, C; Yaschenko, S

    2006-01-01

    The production of omega-mesons in the pp->pp omega reaction has been investigated with the COSY-ANKE spectrometer for excess energies of 60 and 92MeV by detecting the two final protons and reconstructing their missing mass. The large multipion background was subtracted using an event-by-event transformation of the proton momenta between the two energies. Differential distributions and total cross sections were obtained after careful studies of possible systematic uncertainties in the overall ANKE acceptance. The results are compared with the predictions of theoretical models. Combined with data on the phi-meson, a more refined estimate is made of the Okubo-Zweig-Iizuka rule violation in the phi/omega production ratio.

  10. pK+\\Lambda final state: towards the extraction of the ppK- contribution

    CERN Document Server

    Fabbietti, L; Balanda, A; Belver, D; Belyaev, A V; Berger-Chen, J-C; Blanco, A; Böhmer, M; Boyard, J L; Cabanelas, P; Castro, E; Chernenko, S; Christ, T; Destefanis, M; Dohrmann, F; Dybczak, A; Epple, E; Eberl, T; Fateev, O V; Finocchiaro, P; Fonte, P; Friese, J; Fröhlich, I; Galatyuk, T; Garzon, J A; Gernhäuser, R; Gilardi, C; Golubeva, M; Gonzalez-Diaz, D; Guber, F; Gumberidze, M; Heinz, T; Hennino, T; Holzmann, R; Iori, I; Ivashkin, A; Jurkovic, M; Kämpfer, B; Kanaki, K; Karavicheva, T; Koenig, I; Koenig, W; Kolb, B W; Kotte, R; Krasa, A; Krizek, F; Krücken, R; Kuc, H; Kühn, W; Kugler, A; Kurepin, A; Lalik, R; Lang, S; Lange, J S; Lapidus, K; Liu, T; Lopes, L; Lorenz, M; Maier, L; Mangiarotti, A; Markert, J; Metag, V; Michalska, B; Michel, J; Moriniere, E; Mousa, J; Müntz, C; Naumann, L; Otwinowski, J; Pachmayer, Y C; Palka, M; Parpottas, Y; Pechenov, V; Pechenova, O; Pietraszko, J; Przygoda, W; Ramstein, B; Reshetin, A; Rustamov, A; Sadovsky, A; Salabura, P; Schmah, A; Schwab, E; Siebenson, J; Sobolev, Yu G; Spataro, S; Spruck, B; Ströbele, H; Stroth, J; Sturm, C; Tarantola, A; Teilab, K; Tlusty, P; Traxler, M; Trebacz, R; Tsertos, H; Wagner, V; Weber, M; Wendisch, C; Wüstenfel, J; Yurevich, S; Zanevsky, Y V

    2013-01-01

    The reaction p(@3.5\\,GeV)+p -> p+\\Lambda + K^+ can be studied to search for the existence of kaonic bound states like ppK^- leading to this final state. This effort has been motivated by the assumption that in p+p collisions the \\Lambda(1405) resonance can act as a doorway to the formation of the kaonic bound states. The status of this analysis within the HADES collaboration, with particular emphasis on the comparison to simulations, is shown in this work and the deviation method utilized by the DISTO collaboration in a similar analysis is discussed. The outcome suggests the employment of a partial wave analysis to disentangle the different contributions to the measured pK^+\\Lambda final state.

  11. The Multiple Waveform Persistent Peak (MWaPP) Retracker for SAR waveforms

    DEFF Research Database (Denmark)

    Villadsen, Heidi; Andersen, Ole Baltazar; Stenseng, Lars

    using CryoSat-2 20Hz SAR data, but due to the similarities between the Sentinel-3 SRAL altimeter and the SIRAL altimeter on-board CryoSat-2 an adaption of the method will be straightforward. The MWaPP retracker is based on a sub-waveform retracker, but takes the shape of adjacent waveforms into account...... before selecting the sub-waveform belonging to nadir. This is new compared to primary peak retrackers, and alleviates a lot of snagging due to off-nadir bright targets, but also topography challenges. The results from the MWaPP retracker show a significant decrease in the standard deviation of the mean...

  12. A Hydrodynamic Study of p+p Collisions at \\sqrt{s}=7 TeV

    CERN Document Server

    Habich, M; Romatschke, P; Xiang, W

    2015-01-01

    In high energy collisions of heavy-ions, experimental findings of collective flow are customarily associated with the presence of a thermalized medium expanding according to the laws of hydrodynamics. Recently, the ATLAS, CMS and ALICE experiments found signals of the same type and magnitude in ultrarelativistic proton-proton collisions. In this study, the state-of-the art hydrodynamic model SONIC is used to simulate the systems created in p+p collisions. By varying the size of the second-order transport coefficients, the applicability of hydrodynamics itself to the systems created in p+p collisions is quantified. We find that hydrodynamics can give quantitatively reliable results for the particle spectra and the elliptic momentum anisotropy coefficient v2. Using a simple geometric model of the proton based on the elastic form factor leads to results in quantitative agreement with experimental measurements if allowing for a small, but non-vanishing bulk viscosity coefficient.

  13. Energy Dependence of the Transverse Momentum Distributions of Charged Particles in pp Collisions Measured by ALICE

    CERN Document Server

    Abelev, Betty Bezverkhny; Adamova, Dagmar; Adare, Andrew Marshall; Aggarwal, Madan Mohan; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agocs, Andras Gabor; Agostinelli, Andrea; Ahammed, Zubayer; Ahmad, Nazeer; Ahmad, Arshad; Ahmed, Ijaz; Ahn, Sul-Ah; Ahn, Sang Un; Aimo, Ilaria; Aiola, Salvatore; Ajaz, Muhammad; Akindinov, Alexander; Aleksandrov, Dmitry; Alessandro, Bruno; Alexandre, Didier; Alici, Andrea; Alkin, Anton; Alme, Johan; Alt, Torsten; Altini, Valerio; Altinpinar, Sedat; Altsybeev, Igor; Alves Garcia Prado, Caio; Andrei, Cristian; Andronic, Anton; Anguelov, Venelin; Anielski, Jonas; Anticic, Tome; Antinori, Federico; Antonioli, Pietro; Aphecetche, Laurent Bernard; Appelshaeuser, Harald; Arbor, Nicolas; Arcelli, Silvia; Armesto Perez, Nestor; Arnaldi, Roberta; Aronsson, Tomas; Arsene, Ionut Cristian; Arslandok, Mesut; Augustinus, Andre; Averbeck, Ralf Peter; Awes, Terry; Aysto, Juha Heikki Eskeli; Azmi, Mohd Danish; Bach, Matthias Jakob; Badala, Angela; Baek, Yong Wook; Bailhache, Raphaelle Marie; Bala, Renu; Baldisseri, Alberto; Baltasar Dos Santos Pedrosa, Fernando; Ban, Jaroslav; Baral, Rama Chandra; Barbera, Roberto; Barile, Francesco; Barnafoldi, Gergely Gabor; Barnby, Lee Stuart; Ramillien Barret, Valerie; Bartke, Jerzy Gustaw; Basile, Maurizio; Bastid, Nicole; Basu, Sumit; Bathen, Bastian; Batigne, Guillaume; Batyunya, Boris; Batzing, Paul Christoph; Baumann, Christoph Heinrich; Bearden, Ian Gardner; Beck, Hans; Bedda, Cristina; Behera, Nirbhay Kumar; Belikov, Iouri; Bellini, Francesca; Bellwied, Rene; Belmont Moreno, Ernesto; Bencedi, Gyula; Beole, Stefania; Berceanu, Ionela; Bercuci, Alexandru; Berdnikov, Yaroslav; Berenyi, Daniel; Bergognon, Anais Annick Erica; Bertens, Redmer Alexander; Berzano, Dario; Betev, Latchezar; Bhasin, Anju; Bhati, Ashok Kumar; Bhom, Jihyun; Bianchi, Livio; Bianchi, Nicola; Bielcik, Jaroslav; Bielcikova, Jana; Bilandzic, Ante; Bjelogrlic, Sandro; Blanco, Fernando; Blanco, Francesco; Blau, Dmitry; Blume, Christoph; Bock, Friederike; Bogdanov, Alexey; Boggild, Hans; Bogolyubskiy, Mikhail; Boldizsar, Laszlo; Bombara, Marek; Book, Julian Heinz; Borel, Herve; Borissov, Alexander; Bornschein, Joerg; Botje, Michiel; Botta, Elena; Boettger, Stefan; Braidot, Ermes; Braun-Munzinger, Peter; Bregant, Marco; Breitner, Timo Gunther; Broker, Theo Alexander; Browning, Tyler Allen; Broz, Michal; Brun, Rene; Bruna, Elena; Bruno, Giuseppe Eugenio; Budnikov, Dmitry; Buesching, Henner; Bufalino, Stefania; Buncic, Predrag; Busch, Oliver; Buthelezi, Edith Zinhle; Caffarri, Davide; Cai, Xu; Caines, Helen Louise; Caliva, Alberto; Calvo Villar, Ernesto; Camerini, Paolo; Canoa Roman, Veronica; Cara Romeo, Giovanni; Carena, Francesco; Carena, Wisla; Carminati, Federico; Casanova Diaz, Amaya Ofelia; Castillo Castellanos, Javier Ernesto; Casula, Ester Anna Rita; Catanescu, Vasile Ioan; Cavicchioli, Costanza; Ceballos Sanchez, Cesar; Cepila, Jan; Cerello, Piergiorgio; Chang, Beomsu; Chapeland, Sylvain; Charvet, Jean-Luc Fernand; Chattopadhyay, Subhasis; Chattopadhyay, Sukalyan; Cherney, Michael Gerard; Cheshkov, Cvetan Valeriev; Cheynis, Brigitte; Chibante Barroso, Vasco Miguel; Dobrigkeit Chinellato, David; Chochula, Peter; Chojnacki, Marek; Choudhury, Subikash; Christakoglou, Panagiotis; Christensen, Christian Holm; Christiansen, Peter; Chujo, Tatsuya; Chung, Suh-Urk; Cicalo, Corrado; Cifarelli, Luisa; Cindolo, Federico; Cleymans, Jean Willy Andre; Colamaria, Fabio Filippo; Colella, Domenico; Collu, Alberto; Colocci, Manuel; Conesa Balbastre, Gustavo; Conesa Del Valle, Zaida; Connors, Megan Elizabeth; Contin, Giacomo; Contreras Nuno, Jesus Guillermo; Cormier, Thomas Michael; Corrales Morales, Yasser; Cortese, Pietro; Cortes Maldonado, Ismael; Cosentino, Mauro Rogerio; Costa, Filippo; Crochet, Philippe; Cruz Albino, Rigoberto; Cuautle Flores, Eleazar; Cunqueiro Mendez, Leticia; Dainese, Andrea; Dang, Ruina; Danu, Andrea; Das, Kushal; Das, Debasish; Das, Indranil; Dash, Ajay Kumar; Dash, Sadhana; De, Sudipan; Delagrange, Hugues; Deloff, Andrzej; Denes, Ervin Sandor; Deppman, Airton; Oliveira Valeriano De Barros, Gabriel; De Caro, Annalisa; De Cataldo, Giacinto; De Cuveland, Jan; De Falco, Alessandro; De Gruttola, Daniele; De Marco, Nora; De Pasquale, Salvatore; De Rooij, Raoul Stefan; Diaz Corchero, Miguel Angel; Dietel, Thomas; Divia, Roberto; Di Bari, Domenico; Di Giglio, Carmelo; Di Liberto, Sergio; Di Mauro, Antonio; Di Nezza, Pasquale; Djuvsland, Oeystein; Dobrin, Alexandru Florin; Dobrowolski, Tadeusz Antoni; Doenigus, Benjamin

    2013-12-06

    Differential cross sections of charged particles in inelastic pp collisions as a function of $p_T$ have been measured at $\\sqrt{s}$ = 0.9, 2.76 and 7 TeV at the LHC. The $p_T$ spectra are compared to NLO-pQCD calculations. Though the differential cross section for an individual $\\sqrt{s}$ cannot be described by NLO-pQCD, the relative increase of cross section with $\\sqrt{s}$ is in agreement with NLO-pQCD. Based on these measurements and observations, procedures are discussed to construct pp reference spectra at $\\sqrt{s}$ = 2.76 and 5.02 TeV up to $p_T$ = 50 GeV/c as required for the calculation of the nuclear modification factor in nucleus-nucleus and proton-nucleus collisions.

  14. Vector resonances in weak-boson-fusion at future pp colliders

    Science.gov (United States)

    Mohan, Kirtimaan; Vignaroli, Natascia

    2015-10-01

    We present a first estimate of the reach of future pp colliders, the 14 TeV LHC and a futuristic 100 TeV pp collider, on a vector resonance, specifically a W', produced via weak-boson-fusion, and decaying dominantly into tb. The analysis is motivated by Composite Higgs, Randall-Sundrum and Little Higgs scenarios, which predict the existence of vector resonances with a large coupling to W and Z longitudinal bosons. In particular, in composite Higgs models with partial compositeness, the standard Drell-Yan production channel is suppressed at large coupling while the weak-boson-fusion is enhanced and could thus provide a unique opportunity to directly test the large coupling regime of the theory. We outline a search strategy for the W' in the weak-boson-fusion channel and present the reach of future colliders on the W' mass vs coupling parameter space.

  15. Charged kaon femtoscopic correlations in pp collisions at $\\sqrt{s}=7$ TeV

    CERN Document Server

    Abelev, B; Adamova, D; Adare, A M; Aggarwal, M M; Aglieri Rinella, G; Agnello, M; Agocs, A G; Agostinelli, A; Ahammed, Z; Ahmad, N; Ahmad Masoodi, A; Ahn, S U; Ahn, S A; Ajaz, M; Akindinov, A; Aleksandrov, D; Alessandro, B; Alici, A; Alkin, A; Almaraz Avina, E; Alme, J; Alt, T; Altini, V; Altinpinar, S; Altsybeev, I; Andrei, C; Andronic, A; Anguelov, V; Anielski, J; Anson, C; Anticic, T; Antinori, F; Antonioli, P; Aphecetche, L; Appelshauser, H; Arbor, N; Arcelli, S; Arend, A; Armesto, N; Arnaldi, R; Aronsson, T; Arsene, I C; Arslandok, M; Asryan, A; Augustinus, A; Averbeck, R; Awes, T C; Aysto, J; Azmi, M D; Bach, M; Badala, A; Baek, Y W; Bailhache, R; Bala, R; Baldini Ferroli, R.; Baldisseri, A; Baltasar Dos Santos Pedrosa, F; Ban, J; Baral, R C; Barbera, R; Barile, F; Barnafoldi, G G; Barnby, L S; Barret, V; Bartke, J; Basile, M; Bastid, N; Basu, S; Bathen, B; Batigne, G; Batyunya, B; Baumann, C; Bearden, I G; Beck, H; Behera, N K; Belikov, I; Bellini, F; Bellwied, R; Belmont-Moreno, E; Bencedi, G; Beole, S; Berceanu, I; Bercuci, A; Berdnikov, Y; Berenyi, D; Bergognon, A A E; Berzano, D; Betev, L; Bhasin, A; Bhati, A K; Bhom, J; Bianchi, L; Bianchi, N; Bielcik, J; Bielcikova, J; Bilandzic, A; Bjelogrlic, S; Blanco, F; Blanco, F; Blau, D; Blume, C; Boccioli, M; Bottger, S; Bogdanov, A; Boggild, H; Bogolyubsky, M; Boldizsar, L; Bombara, M; Book, J; Borel, H; Borissov, A; Bossu, F; Botje, M; Botta, E; Braidot, E; Braun-Munzinger, P; Bregant, M; Breitner, T; Browning, T A; Broz, M; Brun, R; Bruna, E; Bruno, G E; Budnikov, D; Buesching, H; Bufalino, S; Buncic, P; Busch, O; Buthelezi, Z; Caballero Orduna, D.; Caffarri, D; Cai, X; Caines, H; Calvo Villar, E; Camerini, P; Canoa Roman, V; Cara Romeo, G; Carena, F; Carena, W; Carlin Filho, N; Carminati, F; Casanova Diaz, A; Castillo Castellanos, J; Castillo Hernandez, J F; Casula, E A R; Catanescu, V; Cavicchioli, C; Ceballos Sanchez, C; Cepila, J; Cerello, P; Chang, B; Chapeland, S; Charvet, J L; Chattopadhyay, S; Chattopadhyay, S; Chawla, I; Cherney, M; Cheshkov, C; Cheynis, B; Chibante Barroso, V; Chinellato, D D; Chochula, P; Chojnacki, M; Choudhury, S; Christakoglou, P; Christensen, C H; Christiansen, P; Chujo, T; Chung, S U; Cicalo, C; Cifarelli, L; Cindolo, F; Cleymans, J; Coccetti, F; Colamaria, F; Colella, D; Collu, A; Conesa Balbastre, G; Conesa del Valle, Z; Connors, M E; Contin, G; Contreras, J G; Cormier, T M; Corrales Morales, Y; Cortese, P; Cortes Maldonado, I; Cosentino, M R; Costa, F; Cotallo, M E; Crescio, E; Crochet, P; Cruz Alaniz, E; Cuautle, E; Cunqueiro, L; Dainese, A; Dalsgaard, H H; Danu, A; Das, S; Das, I; Das, D; Das, K; Dash, A; Dash, S; De, S; de Barros, G O V; De Caro, A; De Cataldo, G; de Cuveland, J; De Falco, A; De Gruttola, D; Delagrange, H; Deloff, A; De Marco, N; Denes, E; De Pasquale, S; Deppman, A; D'Erasmo, G; de Rooij, R; Diaz Corchero, M A; Di Bari, D; Dietel, T; Di Giglio, C; Di Liberto, S; Di Mauro, A; Di Nezza, P; Divia, R; Djuvsland, O; Dobrin, A; Dobrowolski, T; Donigus, B; Dordic, O; Driga, O; Dubey, A K; Dubla, A; Ducroux, L; Dupieux, P; Dutta Majumdar, A K; Dutta Majumdar, M R; Elia, D; Emschermann, D; Engel, H; Erazmus, B; Erdal, H A; Espagnon, B; Estienne, M; Esumi, S; Evans, D; Eyyubova, G; Fabris, D; Faivre, J; Falchieri, D; Fantoni, A; Fasel, M; Fearick, R; Fehlker, D; Feldkamp, L; Felea, D; Feliciello, A; Fenton-Olsen, B; Feofilov, G; Fernandez Tellez, A; Ferretti, A; Festanti, A; Figiel, J; Figueredo, M A S; Filchagin, S; Finogeev, D; Fionda, F M; Fiore, E M; Floratos, E; Floris, M; Foertsch, S; Foka, P; Fokin, S; Fragiacomo, E; Francescon, A; Frankenfeld, U; Fuchs, U; Furget, C; Fusco Girard, M; Gaardhoje, J J; Gagliardi, M; Gago, A; Gallio, M; Gangadharan, D R; Ganoti, P; Garabatos, C; Garcia-Solis, E; Garishvili, I; Gerhard, J; Germain, M; Geuna, C; Gheata, M; Gheata, A; Ghosh, P; Gianotti, P; Girard, M R; Giubellino, P; Gladysz-Dziadus, E; Glassel, P; Gomez, R; Ferreiro, E G; Gonzalez-Trueba, L H; Gonzalez-Zamora, P; Gorbunov, S; Goswami, A; Gotovac, S; Graczykowski, L K; Grajcarek, R; Grelli, A; Grigoras, C; Grigoras, A; Grigoriev, V; Grigoryan, S; Grigoryan, A; Grinyov, B; Grion, N; Gros, P; Grosse-Oetringhaus, J F; Grossiord, J Y; Grosso, R; Guber, F; Guernane, R; Guerzoni, B; Guilbaud, M; Gulbrandsen, K; Gulkanyan, H; Gunji, T; Gupta, A; Gupta, R; Haaland, O; Hadjidakis, C; Haiduc, M; Hamagaki, H; Hamar, G; Han, B H; Hanratty, L D; Hansen, A; Harmanova-Tothova, Z; Harris, J W; Hartig, M; Harton, A; Hasegan, D; Hatzifotiadou, D; Hayashi, S; Hayrapetyan, A; Heckel, S T; Heide, M; Helstrup, H; Herghelegiu, A; Herrera Corral, G; Herrmann, N; Hess, B A; Hetland, K F; Hicks, B; Hippolyte, B; Hori, Y; Hristov, P; Hrivnacova, I; Huang, M; Humanic, T J; Hwang, D S; Ichou, R; Ilkaev, R; Ilkiv, I; Inaba, M; Incani, E; Innocenti, G M

    2013-01-01

    Correlations of two charged identical kaons (K$^{ch}$ K$^{ch}$) are measured in pp collisions at $\\sqrt{s}$=7 TeV by the ALICE experiment at the Large Hadron Collider (LHC). One-dimensional K$^{ch}$ K$^{ch}$ correlation functions are constructed in three multiplicity and four transverse momentum ranges. The K$^{ch}$ K$^{ch}$ femtoscopic source parameters R and lambda are extracted. The K$^{ch}$ K$^{ch}$ correlations show a slight increase of femtoscopic radii with increasing multiplicity and a slight decrease of radii with increasing transverse momentum. These trends are similar to the ones observed for $\\pi\\pi$ and $K_s^0 K_s^0$ correlations in pp and heavy-ion collisions. However, the observed one dimensional correlation radii for charged kaons are larger at high multiplicities than those for pions in contrast to what was observed in heavy-ion collisions at RHIC.

  16. pK+Λ final state: Towards the extraction of the ppK- contribution

    Science.gov (United States)

    Fabbietti, L.; Agakishiev, G.; Behnke, C.; Belver, D.; Belyaev, A.; Berger-Chen, J. C.; Blanco, A.; Blume, C.; Böhmer, M.; Cabanelas, P.; Chernenko, S.; Dritsa, C.; Dybczak, A.; Epple, E.; Fateev, O.; Fonte, P.; Friese, J.; Fröhlich, I.; Galatyuk, T.; Garzón, J. A.; Gill, K.; Golubeva, M.; González-Díaz, D.; Guber, F.; Gumberidze, M.; Harabasz, S.; Hennino, T.; Höhne, C.; Holzmann, R.; Huck, P.; Ierusalimov, A.; Ivashkin, A.; Jurkovic, M.; Kämpfer, B.; Karavicheva, T.; Koenig, I.; Koenig, W.; Kolb, B. W.; Korcyl, G.; Kornakov, G.; Kotte, R.; Krása, A.; Krebs, E.; Krizek, F.; Kuc, H.; Kugler, A.; Kurepin, A.; Kurilkin, A.; Kurilkin, P.; Ladygin, V.; Lalik, R.; Lang, S.; Lapidus, K.; Lebedev, A.; Lopes, L.; Lorenz, M.; Maier, L.; Mangiarotti, A.; Markert, J.; Metag, V.; Michel, J.; Müntz, C.; Münzer, R.; Naumann, L.; Palka, M.; Parpottas, Y.; Pechenov, V.; Pechenova, O.; Pietraszko, J.; Przygoda, W.; Ramstein, B.; Rehnisch, L.; Reshetin, A.; Rustamov, A.; Sadovsky, A.; Salabura, P.; Scheib, T.; Schuldes, H.; Siebenson, J.; Sobolev, Yu. G.; Spataro, S.; Ströbele, H.; Stroth, J.; Strzempek, P.; Sturm, C.; Svoboda, O.; Tarantola, A.; Teilab, K.; Tlusty, P.; Traxler, M.; Tsertos, H.; Vasiliev, T.; Wagner, V.; Weber, M.; Wendisch, C.; Wüstenfeld, J.; Yurevich, S.; Zanevsky, Y.

    2013-09-01

    The reaction p(@3.5 GeV)+p→p+Λ+K+ can be studied to search for the existence of kaonic bound states like ppK- leading to this final state. This effort has been motivated by the assumption that in p+p collisions the Λ(1405) resonance can act as a doorway to the formation of the kaonic bound states. The status of this analysis within the HADES Collaboration, with particular emphasis on the comparison to simulations, is shown in this work and the deviation method utilized by the DISTO Collaboration in a similar analysis is discussed. The outcome suggests the employment of a partial wave analysis do disentangle the different contributions to the measured pK+Λ final state.

  17. Effect of hard processes on momentum correlations in $pp$ and $p\\bar{p}$ collisions

    CERN Document Server

    Paic, G; Paic, Guy; Skowronski, Piotr Krzysztof

    2005-01-01

    The HBT radii extracted in p-pbar and pp collisions at SPS and Tevatron show a clear correlation with the charged particle rapidity density. We propose to explain the correlation using a simple model where the distance from the initial hard parton-parton scattering to the hadronization point depends on the energy of the partons emitted. Since the particle multiplicity is correlated with the mean energy of the partons produced we can explain the experimental observations without invoking scenarios that assume a thermal fireball. The model has been applied with success to the existing experimental data both in the magnitude and the intensity of the correlation. As well, the model has been extended to pp collisions at the LHC energy of 14 TeV. The possibilities of a better insight into the string spatial development using 3D HBT analysis is discussed.

  18. Effects of irradiation crosslinking and molecular weight properties on crosslinked PP foaming process

    Energy Technology Data Exchange (ETDEWEB)

    Hong, D.; Yoon, K.J.; Baek, W.S.; Jung, Y.H. [Chungnam National University, Taejon (Korea); Lee, J.G.; Lee, K.I. [Honam Petrochemical Co., Taejon (Korea); Lee, J.H.; Kim, T.S. [Youngbo Chemical Co. Ltd., Ansung (Korea); Lee, K.Y. [Chungnam National University, Taejon (Korea)

    2002-07-01

    The effects of the crosslinking caused by irradiation dose, molecular weights of the foaming materials, and various foaming processes on the foam structure of the polypropylene (PP) were investigated. The maximum gel content of the PP was 48% when the sheet was irradiated with 3.2 Mrad. This high gel content improved the cell structures by providing high thermal stability. The increase of both the gel content and structural development were stopped at the irradiation dose exceeding 3.2 Mrad. The increase of the molecular weights served to help produce a foam with particularly fine and even cell structures, along with improved thermal stability as well. (author). 9 refs., 2 tabs., 15 figs.

  19. PP65 antigenemia in the diagnosis of cytomegalovirus infection in AIDS patients

    Directory of Open Access Journals (Sweden)

    RC Capela

    2012-01-01

    Full Text Available Cytomegalovirus causes significant morbidity and mortality in AIDS patients and those having undergone bone marrow or another transplant. PP65 antigenemia is based on detecting viral antigen in peripheral blood leukocytes through immunochemistry and by monitoring the infection in immunocompromised individuals. The present study aimed to set up this diagnostic technique in AIDS patients with active cytomegalovirus infection and verify its occurrence in the Botucatu region of São Paulo state, Brazil. Fifty patients, 35 men and 15 women aged from 24 to 69 years, were recruited from those attended at the Department of Tropical Diseases of Botucatu Medical School, UNESP, and divided into three groups according to CD4+ T lymphocyte counts and antiretroviral treatment. The control group comprised bone marrow transplant patients. Fourteen AIDS patients with low CD4+ cell counts tested positive for PP65 antigenemia, which could predict cytomegalovirus infection and indicate prophylactic treatment.

  20. Search for electroweak production of single top quarks in pp¯ collisions

    Science.gov (United States)

    Abbott, B.; Abolins, M.; Abramov, V.; Acharya, B. S.; Adams, D. L.; Adams, M.; Alves, G. A.; Amos, N.; Anderson, E. W.; Baarmand, M. M.; Babintsev, V. V.; Babukhadia, L.; Baden, A.; Baldin, B.; Balm, P. W.; Banerjee, S.; Bantly, J.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bean, A.; Begel, M.; Belyaev, A.; Beri, S. B.; Bernardi, G.; Bertram, I.; Besson, A.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Bhattacharjee, M.; Blazey, G.; Blessing, S.; Boehnlein, A.; Bojko, N. I.; Boos, E. E.; Borcherding, F.; Brandt, A.; Breedon, R.; Briskin, G.; Brock, R.; Brooijmans, G.; Bross, A.; Buchholz, D.; Buehler, M.; Buescher, V.; Burtovoi, V. S.; Butler, J. M.; Canelli, F.; Carvalho, W.; Casey, D.; Casilum, Z.; Castilla-Valdez, H.; Chakraborty, D.; Chan, K. M.; Chekulaev, S. V.; Cho, D. K.; Choi, S.; Chopra, S.; Christenson, J. H.; Chung, M.; Claes, D.; Clark, A. R.; Cochran, J.; Coney, L.; Connolly, B.; Cooper, W. E.; Coppage, D.; Cummings, M. A.; Cutts, D.; Dahl, O. I.; Davis, G. A.; Davis, K.; de, K.; del Signore, K.; Demarteau, M.; Demina, R.; Demine, P.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; di Loreto, G.; Doulas, S.; Draper, P.; Ducros, Y.; Dudko, L. V.; Duensing, S.; Dugad, S. R.; Dyshkant, A.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Engelmann, R.; Eno, S.; Eppley, G.; Ermolov, P.; Eroshin, O. V.; Estrada, J.; Evans, H.; Evdokimov, V. N.; Fahland, T.; Feher, S.; Fein, D.; Ferbel, T.; Fisk, H. E.; Fisyak, Y.; Flattum, E.; Fleuret, F.; Fortner, M.; Frame, K. C.; Fuess, S.; Gallas, E.; Galyaev, A. N.; Gartung, P.; Gavrilov, V.; Genik, R. J.; Genser, K.; Gerber, C. E.; Gershtein, Y.; Gibbard, B.; Gilmartin, R.; Ginther, G.; Gómez, B.; Gómez, G.; Goncharov, P. I.; González Solís, J. L.; Gordon, H.; Goss, L. T.; Gounder, K.; Goussiou, A.; Graf, N.; Graham, G.; Grannis, P. D.; Green, J. A.; Greenlee, H.; Grinstein, S.; Groer, L.; Grudberg, P.; Grünendahl, S.; Gupta, A.; Gurzhiev, S. N.; Gutierrez, G.; Gutierrez, P.; Hadley, N. J.; Haggerty, H.; Hagopian, S.; Hagopian, V.; Hahn, K. S.; Hall, R. E.; Hanlet, P.; Hansen, S.; Hauptman, J. M.; Hays, C.; Hebert, C.; Hedin, D.; Heinson, A. P.; Heintz, U.; Heuring, T.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hoftun, J. S.; Hou, S.; Huang, Y.; Ito, A. S.; Jerger, S. A.; Jesik, R.; Johns, K.; Johnson, M.; Jonckheere, A.; Jones, M.; Jöstlein, H.; Juste, A.; Kahn, S.; Kajfasz, E.; Karmanov, D.; Karmgard, D.; Kehoe, R.; Kim, S. K.; Klima, B.; Klopfenstein, C.; Knuteson, B.; Ko, W.; Kohli, J. M.; Kostritskiy, A. V.; Kotcher, J.; Kotwal, A. V.; Kozelov, A. V.; Kozlovsky, E. A.; Krane, J.; Krishnaswamy, M. R.; Krzywdzinski, S.; Kubantsev, M.; Kuleshov, S.; Kulik, Y.; Kunori, S.; Kuznetsov, V. E.; Landsberg, G.; Leflat, A.; Lehner, F.; Li, J.; Li, Q. Z.; Lima, J. G.; Lincoln, D.; Linn, S. L.; Linnemann, J.; Lipton, R.; Lucotte, A.; Lueking, L.; Lundstedt, C.; Maciel, A. K.; Madaras, R. J.; Manankov, V.; Mao, H. S.; Marshall, T.; Martin, M. I.; Martin, R. D.; Mauritz, K. M.; May, B.; Mayorov, A. A.; McCarthy, R.; McDonald, J.; McMahon, T.; Melanson, H. L.; Meng, X. C.; Merkin, M.; Merritt, K. W.; Miao, C.; Miettinen, H.; Mihalcea, D.; Mincer, A.; Mishra, C. S.; Mokhov, N.; Mondal, N. K.; Montgomery, H. E.; Moore, R. W.; Mostafa, M.; da Motta, H.; Nagy, E.; Nang, F.; Narain, M.; Narasimham, V. S.; Neal, H. A.; Negret, J. P.; Negroni, S.; Norman, D.; Oesch, L.; Oguri, V.; Olivier, B.; Oshima, N.; Padley, P.; Pan, L. J.; Para, A.; Parashar, N.; Partridge, R.; Parua, N.; Paterno, M.; Patwa, A.; Pawlik, B.; Perkins, J.; Peters, M.; Peters, O.; Piegaia, R.; Piekarz, H.; Pope, B. G.; Popkov, E.; Prosper, H. B.; Protopopescu, S.; Qian, J.; Quintas, P. Z.; Raja, R.; Rajagopalan, S.; Ramberg, E.; Rapidis, P. A.; Reay, N. W.; Reucroft, S.; Rha, J.; Rijssenbeek, M.; Rockwell, T.; Roco, M.; Rubinov, P.; Ruchti, R.; Rutherfoord, J.; Santoro, A.; Sawyer, L.; Schamberger, R. D.; Schellman, H.; Schwartzman, A.; Sculli, J.; Sen, N.; Shabalina, E.; Shankar, H. C.; Shivpuri, R. K.; Shpakov, D.; Shupe, M.; Sidwell, R. A.; Simak, V.; Singh, H.; Singh, J. B.; Sirotenko, V.; Slattery, P.; Smith, E.; Smith, R. P.; Snihur, R.; Snow, G. R.; Snow, J.; Snyder, S.; Solomon, J.; Sorín, V.; Sosebee, M.; Sotnikova, N.; Soustruznik, K.; Souza, M.; Stanton, N. R.; Steinbrück, G.; Stephens, R. W.; Stevenson, M. L.; Stichelbaut, F.; Stoker, D.; Stolin, V.; Stoyanova, D. A.; Strauss, M.; Streets, K.; Strovink, M.; Stutte, L.; Sznajder, A.; Taylor, W.; Tentindo-Repond, S.; Thompson, J.; Toback, D.; Tripathi, S. M.; Trippe, T. G.; Turcot, A. S.; Tuts, P. M.; van Gemmeren, P.; Vaniev, V.; van Kooten, R.; Varelas, N.; Volkov, A. A.; Vorobiev, A. P.; Wahl, H. D.; Wang, H.; Wang, Z.-M.; Warchol, J.; Watts, G.; Wayne, M.; Weerts, H.; White, A.; White, J. T.; Whiteson, D.; Wightman, J. A.; Wijngaarden, D. A.; Willis, S.; Wimpenny, S. J.; Wirjawan, J. V.; Womersley, J.; Wood, D. R.; Yamada, R.; Yamin, P.; Yasuda, T.; Yip, K.; Youssef, S.; Yu, J.; Yu, Z.; Zanabria, M.; Zheng, H.; Zhou, Z.; Zhu, Z. H.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zutshi, V.; Zverev, E. G.; Zylberstejn, A.

    2001-02-01

    We present a search for electroweak production of single top quarks in the electron+jets and muon+jets decay channels. The measurements use ~90 pb-1 of data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with the DØ detector between 1992 and 1995. We use events that include a tagging muon, implying the presence of a b jet, to set an upper limit at the 95% confidence level on the cross section for the s-channel process pp¯-->tb+X of 39 pb. The upper limit for the t-channel process pp¯-->tqb+X is 58 pb.

  1. Measurements of the total, elastic and inelastic pp cross section with ATLAS

    CERN Document Server

    Heinz, Christian; The ATLAS collaboration

    2016-01-01

    The total pp cross section is a fundamental property of the strong interaction which can not be calculated in perturbative QCD but only described based on phenomenological models. The ATLAS collaboration has recently measured the total inelastic protonproton cross section and the diffractive part of the inelastic cross section at 13 TeV in special data sets taken with low beam currents and using forward scintillators. A more precise measurement of the total pp cross section as well as elastic and inelastic contributions has been extracted from a measurement of the differential elastic cross section using the optical theorem. The ATLAS Collaboration has performed this measurement in elastic data collected with high beta* optics at 8 TeV centreofmass energy with the ALFA Roman Pot detector. From the extrapolation of the differential elastic cross section to t=0, using the optical theorem, the total cross section is extracted in a luminositydependent method with unprecedented precision. In addition the nuclear s...

  2. Battery charger PP-6309()/U. Final report, 1 Jul 1969--30 Jul 1970

    Energy Technology Data Exchange (ETDEWEB)

    Froeschle, T.A.; Hill, H.W. Jr.

    1971-01-01

    The performance data and design configuration of the PP-6309 ()/U Battery Charger is delineated. Performance of the unit is summarized and analyzed. Terminal performance and selected aspects of internal performance are considered. The internal system configuration of the Battery Charger is presented in block form. Functions of individual system blocks are discussed to define their behavior. Circuit components used to implement the system blocks are identified. The PP-6309 ()/U Battery Charger is designed to charge 24 Vdc--28 Vdc batteries at adjustable charging rates from 5 Adc--15 Adc. The unit operates from 28 Vdc power sources having the characteristics of MIL-STD-704A. The Battery Charger is housed in a finned rectangular enclosure; the total weight is 26 pounds. (auth)

  3. Battery charger PP-4126( )/U. Final report, 1 Jul 1971--Jun 1974

    Energy Technology Data Exchange (ETDEWEB)

    Froeschle, T.A.

    1975-07-01

    The performance data and design configuration of the PP-4126( )/U Battery Charger are delineated in this final report. Performance of the unit is summarized. Terminal performance and selected aspects of internal performance are considered. The internal system configuration of the battery charger is presented in block form. Functions of internal system blocks are discussed to define their design and behavior. Circuit components used to implement the systems blocks are identified. The PP-4126( )/U Battery Charger is designed to charge 6-, 12-, and 24-V dc batteries at selectable charging rates from 0.1 A dc to 12 A dc. The battery charger operates from MIL-STD-704 dc power sources in the range 22 V dc to 40 V dc. The battery charger structure is a finned housing with a removable cover. The cover contains the input power cable. The battery charger may be operated in any position.

  4. Determination of the number of participating nucleons in p+p interactions at SPS energies

    CERN Document Server

    Stroebele, H

    2016-01-01

    In the past the analyses of inelastic p+p collision for example in terms of the hadron gas model have assumed that always both protons participate in the interaction. In this article we show that (at sqrt(s) = 17.3 GeV ) on average only 1,89 protons are interacting. Measurements of the mean multiplicities of protons, neutrons, charged pions, charged kaons and {\\Lambda} hyperons allow to compute the number of initial state nucleons using conservation of baryon number, strangeness, and isospin. We further argue that once the number of initial state nucleons is given and the mean multiplicities of protons and charged pions are known in p+p interactions at center-of-mass energies below a few tens of GeV, the yields of net neutrons, kaons, and hyperons can be estimated with a precision of a few percent using again baryon and isospin conservation.

  5. Final-state interactions in the process anti pp {yields} pK{sup +} {Lambda}

    Energy Technology Data Exchange (ETDEWEB)

    Roeder, M.; Borodina, E.; Dzhygadlo, R.; Gast, W.; Gillitzer, A.; Grzonka, D.; Kilian, K.; Mertens, M.; Ritman, J.; Roderburg, E.; Sefzick, T.; Wintz, P. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Clement, H.; Doroshkevich, E.; Ehrhardt, K.; Erhardt, A. [Physikalisches Institut der Universitaet Tuebingen, Tuebingen (Germany); University of Tuebingen, Kepler Center for Astro and Particle Physics, Tuebingen (Germany); Eyrich, W.; Kober, L.; Krapp, M. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen (Germany); Haidenbauer, J.; Hanhart, C. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Forschungszentrum Juelich, Institute for Advanced Simulation, Juelich (Germany); Hauenstein, F.; Klaja, P. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen (Germany); Schroeder, W. [Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Sibirtsev, A. [Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany); Wuestner, P. [Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Forschungszentrum Juelich, Zentralinstitut fuer Elektronik, Juelich (Germany); Collaboration: The COSY-TOF Collaboration

    2013-12-15

    The possibility to determine the p{Lambda} scattering length from the final-state interaction in the reaction anti pp {yields} pK{sup +} {Lambda} is investigated experimentally. From a transversely polarized measurement, the K{sup +} analyzing power (A{sub N}) which, in principle, allows one to extract the spin triplet scattering length is studied. An unexpected energy dependence of the forward/backward symmetric part of A{sub N} is found. The influence of N {sup *} resonances on the p {Lambda} invariant mass spectrum is investigated by exploiting the large acceptance for the process anti pp {yields} pK{sup +} {Lambda} {yields} pK{sup +} p{pi}{sup -} and is found to be the main source of uncertainty for determining the p{Lambda} scattering length. (orig.)

  6. On the {Sigma}N cusp in the pp {yields} pK{sup +}{Lambda} reaction

    Energy Technology Data Exchange (ETDEWEB)

    Abd El-Samad, S. [Atomic Energy Authority NRC Cairo, Cairo (Egypt); Borodina, E.; Dzhygadlo, R.; Gast, W.; Gillitzer, A.; Grzonka, D.; Kilian, K.; Ritman, J.; Roderburg, E.; Roeder, M.; Sefzick, T.; Wintz, P. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Brinkmann, K.T. [Physikalisches Institut Justus-Liebig-Universitaet, Giessen (Germany); Clement, H.; Doroshkevich, E.; Ehrhardt, K.; Erhardt, A.; Wagner, G.J. [Physikalisches Institut der Universitaet Tuebingen, Tuebingen (Germany); University of Tuebingen, Kepler Center for Astro and Particle Physics, Tuebingen (Germany); Eyrich, W.; Krapp, M.; Schulte-Wissermann, M. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen (Germany); Freiesleben, H. [Technische Universitaet Dresden, Institut fuer Kern- und Teilchenphysik, Dresden (Germany); Hanhart, C. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Forschungszentrum Juelich, Institute for Advanced Simulation, Juelich (Germany); Hauenstein, F.; Klaja, P.; Schroeder, W. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Erlangen (Germany); Wuestner, P. [Forschungszentrum Juelich, Institut fuer Kernphysik, Juelich (Germany); Forschungszentrum Juelich, Juelich Center for Hadron Physics, Juelich (Germany); Forschungszentrum Juelich, Zentralinstitut fuer Elektronik, Juelich (Germany); Collaboration: COSY-TOF Collaboration

    2013-03-15

    Measurements of the pp {yields} pK {sup +} {Lambda} reaction at T{sub p} = 2.28 GeV have been carried out at COSY-TOF. In addition to the {Lambda}p FSI and N {sup *} resonance excitation effects a pronounced narrow structure is observed in the Dalitz plot and in its projection on the p {Lambda} invariant mass. The strongly asymmetric structure appears at the pp {yields} NK {sup +} {Sigma} threshold and is interpreted as the {Sigma}N cusp effect. The observed width of about 20 MeV/c {sup 2} is substantially broader than anticipated from previous measurements as well as theoretical predictions. Angular distributions of this cusp structure are shown to be dissimilar to those in the residual pK {sup +} {Lambda} channel, but similar to those observed in the pK {sup +} {Sigma} {sup 0} channel. (orig.)

  7. On the SigmaN cusp in the pp -> pK+Lambda reaction

    CERN Document Server

    El-Samad, S Abd; Brinkmann, K -Th; Clement, H; Doroshkevich, E; Dzhygadlo, R; Ehrhardt, K; Erhardt, A; Eyrich, W; Freiesleben, H; Gast, W; Gillitzer, A; Grzonka, D; Hanhart, C; Hauenstein, F; Klja, P; Kilian, K; Krapp, M; Ritman, J; Roderburg, E; Roeder, M; Schulte-Wissermann, M; Schroeder, W; Sfzick, T; Wagner, G J; Wintz, P; Wuestner, P

    2012-01-01

    Measurements of the $pp \\to pK^+\\Lambda$ reaction at $T_p$ = 2.28 GeV have been carried out at COSY-TOF. In addition to the $\\Lambda p$ FSI and $N^*$ resonance excitation effects a pronounced narrow structure is observed in the Dalitz plot and in its projection on the $p\\Lambda$-invariant mass. The structure appears at the $pp \\to $N$K^+\\Sigma$ threshold and is interpreted as $\\Sigma$N cusp effect. The observed width of 20 MeV/$c^2$ is substantially broader than anticipated from previous inclusive measurements. Angular distributions of this cusp structure are shown to be dissimilar to those in the residual $pK^+\\Lambda$ channel, but similar to those observed in the $pK^+\\Sigma^0$ channel.

  8. Final-State Interactions in the Process pp -> pKLambda

    CERN Document Server

    Röder, M; Clement, H; Doroshkevich, E; Dzhygadlo, R; Ehrhardt, K; Erhardt, A; Eyrich, W; Gast, W; Gillitzer, A; Grzonka, D; Haidenbauer, J; Hanhart, C; Hauenstein, F; Klaja, P; Kober, L; Kilian, K; Krapp, M; Mertens, M; Ritman, J; Roderburg, E; Schroeder, W; Sefzick, T; Sibirtsev, A; Wintz, P; Wüstner, P

    2013-01-01

    The possibility to determine the pLambda scattering length from the final-state interaction in the reaction pp->pKLambda is investigated experimentally. From a transversely polarized measurement, the K analyzing power (A_N) which, in principle, allows one to extract the spin triplet scattering length is studied. An unexpected energy dependence of the forward/backward symmetric part of A_N is found. The influence of N*-resonances on the pLambda invariant mass spectrum is investigated by exploiting the large acceptance for the process pp->pKLambda->pKppi and is found to be the main source of uncertainty for determining the pLambda scattering length.

  9. On the ΣN cusp in the pp → pK+Λ reaction

    Science.gov (United States)

    Abd El-Samad, S.; Borodina, E.; Brinkmann, K.-Th.; Clement, H.; Doroshkevich, E.; Dzhygadlo, R.; Ehrhardt, K.; Erhardt, A.; Eyrich, W.; Freiesleben, H.; Gast, W.; Gillitzer, A.; Grzonka, D.; Hanhart, C.; Hauenstein, F.; Klaja, P.; Kilian, K.; Krapp, M.; Ritman, J.; Roderburg, E.; Röder, M.; Schulte-Wissermann, M.; Schroeder, W.; Sefzick, T.; Wagner, G. J.; Wintz, P.; Wüstner, P.

    2013-03-01

    Measurements of the pp → pK + Λ reaction at T p = 2.28 GeV have been carried out at COSY-TOF. In addition to the Λp FSI and N * resonance excitation effects a pronounced narrow structure is observed in the Dalitz plot and in its projection on the pΛ invariant mass. The strongly asymmetric structure appears at the pp → NK + Σ threshold and is interpreted as the ΣN cusp effect. The observed width of about 20 MeV/ c 2 is substantially broader than anticipated from previous measurements as well as theoretical predictions. Angular distributions of this cusp structure are shown to be dissimilar to those in the residual pK + Λ channel, but similar to those observed in the pK + Σ 0 channel.

  10. Detection of human CMV PP65 protein in glioma brain tumors with immunohistochemistry method

    Directory of Open Access Journals (Sweden)

    MR. Jabbari

    2015-08-01

    Full Text Available Background: Human cytomegalovirus (HCMV may play a role in the development of glioma disease that is one of the most common brain tumors. Objective: The aim of this study was to detect human CMV in patients with glioma in Imam Khomeini hospital, Tehran. Methods: This experimental study was conducted on paraffin-embedded tumor samples of 18 patients referred to Imam Khomeini hospital in 2012. Immunohistochemistry (IHC was performed with monoclonal antibody specific for HCMV PP65 protein and the samples were assessed using a light microscope. Findings: Of 18 patients, 13 (72.2% were positive for HCMV PP65 protein and four of them expired. Conclusion: With regards to the results, more comprehensive studies are recommended for detection of HCMV in patients with glioma using different diagnostic methods.

  11. Charmonium production in pp, pPb and PbPb with CMS

    CERN Document Server

    Lee, Songkyo

    2016-01-01

    We report on the analysis of charmonia in pp, pPb and PbPb collisions with the CMS experiment with various observables. The cross section for coherent J/$\\psi$ photoproduction is measured in ultra-peripheral PbPb collisions at 2.76 TeV. The ratio of yields at forward (proton-going direction) and backward (Pb-going direction) is studied as a function of $p_{\\rm T}$, rapidity, and the event activity in pPb collisions at 5.02 TeV. The nuclear modification factor of prompt J/$\\psi$ in PbPb collisions at 2.76 TeV is presented as a function of centrality, $p_{\\rm T}$, and rapidity. Finally, the production yields of $\\psi$(2S) and J/$\\psi$ in pp and PbPb collisions have been compared.

  12. EFFECT OF FILLER LOADING ON PHYSICAL AND FLEXURAL PROPERTIES OF RAPESEED STEM/PP COMPOSITES

    Directory of Open Access Journals (Sweden)

    Seyed Majid Zabihzadeh

    2011-03-01

    Full Text Available The objective of the study is to develop a new filler for the production of natural filler thermoplastic composites using the waste rapeseed stalks. The long-term water absorption and thickness swelling behaviors and flexural properties of rapeseed filled polypropylene (PP composites were investigated. Three different contents of filler were tested: 30, 45, and 60 wt%. Results of long-term hygroscopic tests indicated that by the increase in filler content from 30% to 60%, water diffusion absorption and thickness swelling rate parameter increased. A swelling model developed by Shi and Gardner can be used to quantify the swelling rate. The increasing of filler content reduced the flexural strength of the rapeseed/PP composites significantly. In contrast to the flexural strength, the flexural modulus improved with increasing the filler content. The flexural properties of these composites were decreased after the water uptake, due to the effect of the water molecules.

  13. Influence of porous PTFE/LDPE/PP composite electret in skin ultrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, J; Liang, Y Y; Tang, Y; Ye, X T; Yang, Y J; Song, M H [Department of Physics and Mathematics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433 (China); Cui, L L; Hou, X M [Department of Inorganic Chemistry, College of Pharmacy, Second Military Medical University, Shanghai, 200433 (China)], E-mail: jjiang0827@hotmail.com, E-mail: cuilili39@hotmail.com

    2008-12-01

    Corona charging and heat melting method were used to prepare porous PTFE electret and porous PTFE/LDPE/PP composite electret, respectively. After 0.5, 1, 1.5, 3 and 4 hour's action of fluorescein sodium (FINa) and -300V porous PTFE/LDPE/PP composite electret on the excised abdominal skin of rat, the skin structure was studied by means of scanning electron microscopy, transmission electron microscopy and confocal laser scanning microscopy, respectively, to probe the mechanism of electret on transdermal drug delivery. The results indicated that negative electret could increase the transdermal delivery of FINa due to its effect on changing the organized structure of stratum corneum, enlarging the hair follicles, which may be the mechanism of electret in enhancing transdermal drug delivery.

  14. Correlations, multiplicity distributions, and the ridge in pp and p-Pb collisions

    Science.gov (United States)

    Ohlson, Alice

    2017-04-01

    Measurements made by the ALICE Collaboration of single- and two-particle distributions in high-energy pp and p-Pb collisions are used to characterize the interactions in small collision systems, tune models of particle production in QCD, and serve as a baseline for heavy-ion observables. The measurements of charged-particle multiplicity density, , and multiplicity distributions are shown in pp and p-Pb collisions, including data from the top center-of-mass energy achieved at the Large Hadron Collider (LHC), √S = 13 TeV. Two-particle angular correlations in p-Pb collisions are studied in detail to investigate long-range correlations in pseudorapidity which are reminiscent of structures previously thought unique to heavy-ion collisions.

  15. Analyzing power measurements in pn r arrow. pi. sup minus pp ( sup 1 S sub 0 )

    Energy Technology Data Exchange (ETDEWEB)

    Bachman, M.; Riley, P. (Department of Physics, The University of Texas at Austin, Austin, TX (USA)); Hollas, C. (Q-2 Division, Los Alamos National Laboratory, Los Alamos, NM (USA))

    1990-10-01

    A recent experiment has measured analyzing powers in {ital d}({ital {rvec p}},{pi}{sup {minus}}{ital pp}){ital p} in a geometry which selected the quasifree two-body reaction {ital {rvec p}n}{r arrow}{pi}{sup {minus}}{ital pp}({sup 1}{ital S}{sub 0}). Analysis of the results indicated a significant contribution from a very-short-range part of the nucleon-nucleon interaction. We show that the analyzing power data measured in the above experiment is reasonably well described by a unitary {ital NN} {r arrow} {ital NN}{pi} model containing only the one-pion-exchange driving force.

  16. Search for narrow resonances in pp. -->. p. pi. /sup +/n at 2 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, J.R.; Wicklund, A.B.; Arenton, M.W.

    1980-07-01

    A preliminary analysis of an experiment designed as a sensitive dibaryon resonance search in the reaction pp..-->..p..pi../sup +/n is presented. At 2 GeV/c incident momentum, 440,000 unambiguously reconstructed events were obtained. In this preliminary analysis, the results are reported of a search of the pn mass spectrum for evidence of chain decays of possible dibaryon resonances, i.e. pp..-->..d/sup **/, d/sup **/..-->..d/sup **/..pi../sup +/, d/sup */..-->..pn. No evidence of narrow peaks (less than or equal to 7 MeV) is seen in the data for cross-section-times-branching-ratio greater than 50 ..mu..b.

  17. INTROMISSION OF WATER-REPELLENT AND HYDROSCOPIC PROPERTIES SIMULTANEOUSLY TO PP BY PLASMA DISCHARGE METHOD

    Institute of Scientific and Technical Information of China (English)

    Jie Liang; Bi-qian Liu

    2005-01-01

    Plasma-induced surface graft copolymerization of acrylic acid on polypropylene non-woven fabric (PP-g-AA) and polypropylene membrane were reported. The extents of grafting were controlled by the plasma and polymerization condition. Hexadecyltrimethyl ammonium bromide was then coupled with the carboxyl group of PP-g-AA to obtain a polyion complex (PIC). At last, CF4 plasma was used to give PICs hydrophobic property. The moisture regain and waterrepellency of the processed PICs was investigated. The surfaces were characterized using ATR FT-IR and XPS. The result indicates that the products have very high ability to adsorb moisture, even better than cotton fiber. At the same time, the products show excellent hydrophobic property, which can't be wetted by those reagents whose surface tensions were higher than 327 mN/m.

  18. Vector resonances in weak-boson-fusion at future pp colliders

    CERN Document Server

    Mohan, Kirtimaan

    2015-01-01

    We present a first estimate of the reach of future pp colliders, the 14 TeV LHC and a futuristic 100 TeV pp collider, on a vector resonance, specifically a $W^{'}$, produced via weak-boson-fusion, and decaying dominantly into $tb$. The analysis is motivated by Composite Higgs, Randall-Sundrum and Little Higgs scenarios, which predict the existence of vector resonances with a large coupling to $W$ and $Z$ longitudinal bosons. In particular, in composite Higgs models with partial compositeness, the standard Drell-Yan production channel is suppressed at large coupling while the weak-boson-fusion is enhanced and could thus provide a unique opportunity to directly test the large coupling regime of the theory. We outline a search strategy for the $W^{'}$ in the weak-boson-fusion channel and present the reach of future colliders on the $W^{'}$ mass-coupling parameter space.

  19. PDMS表面包覆APP制备阻燃PP%The flame-retardant PP prepared by APP with PDMS coat

    Institute of Scientific and Technical Information of China (English)

    王中

    2013-01-01

    研究PDMS表面包覆改性聚磷酸铵及其阻燃PP性能的变化情况.以聚二甲基硅氧烷(PDMS)预聚体为包覆剂对APP进行表面包覆改性制备疏水APP,然后将改性APP与自制的三嗪类成炭发泡剂(CFA)、SiO2作为协效剂复配成膨胀型阻燃剂(IFR)加入到聚丙烯中制备阻燃聚丙烯材料.分析PDMS改性对阻燃PP复合材料的阻燃性能、力学性能和耐水性能的影响.CFA与APP进行1:4的复配,加入到PP中.随着阻燃剂的增加,材料的氧指数逐渐增加,当表面包覆APP添加量达15%时,改性后氧指数达28.8,阻燃性能达到了UL94-V0级.而未改性阻燃剂添加量达到17%时才达到UL 94一V0要求的氧指数28.5;材料的力学性能随阻燃剂的增加而下降.通过包覆,耐水性能有很大提高.%The performance change of APP coated with PDMS and the flame- retardant PP made by it were researched. Method : the APP was coated by performed polymer of PDMS to prepare the hydrophobic APP. The modified APP and homemade triazines carbon foaming agent (CFA) and Silicon Dioxide were used as synergist to prepare intumescing flame retardant (1FR), which was used into PP to prepare flame-retardant PP. The influence on the fire resistance and mechanical property and hydrolytic resistance of flame-retardant PP by PDMS was analyzed. The CFA and APP was added into the PP with 1 : 4. Results: with the increase of flame retardants, the oxygen index of the material is gradually increased. When the added a-mount of surface covered APP reaches 15%, the LOI reaches 28.8, and the flame retardant reached level UL 94 - V0. It takes 17% for unmodified APP to reach level of UL 94 -V0, and the LOI of 28. 5. The mechanical properties of the material gradually decline with increasing flame retardants. The hydrolytic resistance has greatly improved by coating.

  20. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

    Energy Technology Data Exchange (ETDEWEB)

    Boylan, Joan M. [Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, RI (United States); Salomon, Arthur R. [Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (United States); Department of Chemistry, Brown University, Providence, RI (United States); Tantravahi, Umadevi [Division of Genetics, Department of Pathology, Brown University and Women and Infants Hospital, Providence, RI (United States); Gruppuso, Philip A., E-mail: philip_gruppuso@brown.edu [Department of Pediatrics, Brown University and Rhode Island Hospital, Providence, RI (United States); Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI (United States)

    2015-07-15

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders. - Highlights: • Lentiviral-transduced shRNA was used to generate a stable knockdown of PP6 in HepG2 cells. • Cells adapted to reduced PP6; cell proliferation was unaffected, and cell survival was normal. • However, PP6 knockdown was associated with a transition to a tetraploid state. • Genomic profiling showed downregulated anti-inflammatory signaling and DNA replication. • Phosphoproteomic profiling showed changes in proteins associated with DNA replication and repair.

  1. The constancy of global regulation across a species: the concentrations of ppGpp and RpoS are strain-specific in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Phan Katherine

    2011-03-01

    Full Text Available Abstract Background Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS are potentially subject to variability across the species Escherichia coli. To find out the extent of strain variation we measured the level of RpoS and ppGpp using 31 E. coli strains from the ECOR collection and one reference K-12 strain. Results Nine ECORs had highly deleterious mutations in rpoS, 12 had RpoS protein up to 7-fold above that of the reference strain MG1655 and the remainder had comparable or lower levels. Strain variation was also evident in ppGpp accumulation under carbon starvation and spoT mutations were present in several low-ppGpp strains. Three relationships between RpoS and ppGpp levels were found: isolates with zero RpoS but various ppGpp levels, strains where RpoS levels were proportional to ppGpp and a third unexpected class in which RpoS was present but not proportional to ppGpp concentration. High-RpoS and high-ppGpp strains accumulated rpoS mutations under nutrient limitation, providing a source of polymorphisms. Conclusions The ppGpp and σS variance means that the expression of genes involved in translation, stress and other traits affected by ppGpp and/or RpoS are likely to be strain-specific and suggest that influential components of regulatory networks are frequently reset by microevolution. Different strains of E. coli have different relationships between ppGpp and RpoS levels and only some exhibit a proportionality between increasing ppGpp and RpoS levels as demonstrated for E. coli K-12.

  2. Compatibilizing agents influence on mechanical properties of PP/clay nanocomposites

    DEFF Research Database (Denmark)

    Sanporean, Catalina-Gabriela; Donescu, Dan; Vuluga, Zina

    2013-01-01

    stiren-etilen-butilenstirenul maleinizat (MA-SEBS). Nanocompozitele de polipropilenă astfel obţinute au prezentat cristalinitate şi grosime lamelară crescută. Nanocompozitele cu MA-PP au prezentat, în general, proprietăţi mecanice îmbunătăţite, în special rezistenţa la tracţiune, rezistenţa la fluaj şi...

  3. Covariant Helicity Amplitude Analysis for J/ψ→γPP

    Institute of Scientific and Technical Information of China (English)

    WU Ning; RUAN Tu-Nan

    2001-01-01

    Covariant helicity amplitude analysis for the process of J/ψ →γPP is discussed.Starting from the S- matrix elements of decay process,we deduce the formulae of helicity coupling amplitudes for two-body decay process. These formulae are used to analyze intermediate resonance states in the process of J/ψ decay to γππ,γKK,γηη' etc.

  4. Essential functions of Sds22p in chromosome stability and nuclear localization of PP1.

    Science.gov (United States)

    Peggie, Mark W; MacKelvie, Sarah H; Bloecher, Andrew; Knatko, Elena V; Tatchell, Kelly; Stark, Michael J R

    2002-01-01

    Sds22p is a conserved, leucine-rich repeat protein that interacts with the catalytic subunit of protein phosphatase 1 (PP1(C)) and which has been proposed to regulate one or more functions of PP1(C) during mitosis. Here we show that Saccharomyces cerevisiae Sds22p is a largely nuclear protein, most of which is present as a sTable 1:1 complex with yeast PP1(C) (Glc7p). Temperature-sensitive (Ts(-)) S. cerevisiae sds22 mutants show profound chromosome instability at elevated growth temperatures but do not confer a cell cycle stage-specific arrest. In the sds22-6 Ts(-) mutant, nuclear Glc7p is both reduced in level and aberrantly localized at 37 degrees C and the interaction between Glc7p and Sds22p in vitro is reduced at higher temperatures, consistent with the in vivo Ts(-) growth defect. Like some glc7 mutations, sds22-6 can suppress the Ts(-) growth defect associated with ipl1-2, a loss of function mutation in a protein kinase that is known to work in opposition to PP1 on at least two nuclear substrates. This, together with reciprocal genetic interactions between GLC7 and SDS22, suggests that Sds22p functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for faithful transmission of chromosomes during mitosis, and this role is at least partly mediated by effects of Sds22p on the nuclear distribution of Glc7p

  5. Factorial correlator data from pp collisions at 400GeV/c

    Institute of Scientific and Technical Information of China (English)

    王韶舜; 李祖豪; 张杰; 肖臣国; 叶云秀

    1996-01-01

    The factorial correlators have been calculated by using the experimental data of the pseudorapidity distribution of the charged particles produced in pp collisions at 400GeV/c. The results show that the factorial correlators increase with the decrease of the correlation distance independently of the pseudorapidity resolution. Th