Human attitudes towards herpetofauna: The influence of folklore and negative values on the conservation of amphibians and reptiles in Portugal

Science.gov (United States)

2012-01-01

Background Human values and folklore of wildlife strongly influence the effectiveness of conservation efforts. These values and folklore may also vary with certain demographic characteristics such as gender, age, or education. Reptiles and amphibians are among the least appreciated of vertebrates and are victims of many negative values and wrong ideas resulting from the direct interpretation of folklore. We try to demonstrate how these values and folklore can affect the way people relate to them and also the possible conservation impacts on these animals. Methods A questionnaire survey distributed to 514 people in the district of Évora, Portugal, was used to obtain data regarding the hypothesis that the existence of wrong ideas and negative values contributes to the phenomenon of human-associated persecution of these animals. A structural equation model was specified in order to confirm the hypothesis about the possible relationships between the presence of perceptions and negative values about amphibians and reptiles and persecution and anti-conservation attitudes. Sociodemographic variables were also added. Results The results of the model suggest that the presence of folklore and negative values clearly predicts persecution and anti-conservation attitudes towards amphibians and reptiles. Also, the existence of folklore varies sociodemographically, but negative values concerning these animals are widespread in the population. Conclusions With the use of structural equation models, this work is a contribution to the study of how certain ideas and values can directly influence human attitudes towards herpetofauna and how they can be a serious conservation issue. PMID:22316318

Folkloric Art in Egyptian Schools.

Science.gov (United States)

Osman, Siham

1983-01-01

Theories in art education with a western origin have been applied in Egypt to support the revival of folkloric art. There are three important phases in the teaching of a unit on applique, a decorative craft dating back to the earliest Egyptian history. (AM)

Childbirth in ancient Rome: from traditional folklore to obstetrics.

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Todman, Donald

2007-04-01

In ancient Rome, childbirth was a hazardous event for both mother and child with high rates of infant and maternal mortality. Traditional Roman medicine centred on folklore and religious practices, but with the development of Hippocratic medicine came significant advances in the care of women during pregnancy and confinement. Midwives or obstetrices played an important role and applied rational scientific practices to improve outcomes. This evolution from folklore to obstetrics was a pivotal point in the history of childbirth.

NETWORK FOLKLORE AND ITS ROLE IN THE FORMATION OF A COLLECTIVE COGNITIVE SPACE

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Anastasija Belovodskaja

2014-04-01

Full Text Available The global implementation of information-communicative technologies into every sphere of human activity is being accompanied by the emergence of new forms of communication, le­ading to inevitable changes in the means of both the representation and reception of information. In this respect, the field of interest encompasses research into modern anonymous network creative writing, which, as a result of the technological qualities of the Internet space, produces such texts that require particular skills in both comprehension and reproduction. In turn, the products of network folklore, as they spontaneously spread on the Internet, acquire the status of particular signs of a precedent nature. At the same time, the very nature of anonymous network creative writing—amusing and colloquial—raises the attractiveness of such texts and facilitates their reception, allowing them to be used for manipulative aims. The fact that such network folklore can influence the process of idea-formation in society is predetermined by the fact that, by definition, it is the milieu where collective representations are condensed and transmitted. Thus, network folklore is in the focus of attention not only in folklore studies, but is extremely topical for research in such fields as cognitive science, linguistic-cultural studies, public relations, speech effect, and any others which take interest in the processes of keeping, receiving, and transmitting information.

Of Mermaids and Changelings: Human Rights, Folklore and Contemporary Irish Language Poetry

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Rióna Ní Fhrighil

2017-10-01

Full Text Available This article investigates the intersection of human rights discourse, Irish folklore and contemporary Irish-language poetry. The author contends that contemporary Irish-language poets Louis de Paor and Nuala Ní Dhomhnaill exploit the multi-faceted nature of international folklore motifs, along with their local variants, to represent human rights violations in their poetry. Focusing specifically on the motif of the changeling in De Paor’s poetry and on the motif of the mermaid in Ní Dhomhnaill’s, the author traces how folklore material is reimagined in ways that eschew uncomplicated transnational solidarity but which engender empathetic settlement.

Folklore and Folk Songs of Chittagong: A Critical Review

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Amir Mohammad Khan

2017-04-01

Full Text Available Folk Songs stems from Folklore are very rich in the southern region of Chittagong. In this part of the world Folk Songs play pivotal role in the lifestyle of people as a heart-touching and heavenly connection exists between human, nature and Folk Songs. Folk Songs in this area are special because we found the theme of Nature Conservation in them. We took the southern part of Chittagong (Lohagara, Satkania, Chandanaish and Patiya as our research area, selected a village namely Chunati in the systematic sampling and more than 100 people were interviewed through focus group discussion and key informant interviews. The sufficient literature review is also done. People in this area love nature a lot. Here music personnel were born from time to time who not only worked for the musical development but also created consciousness among people to love nature and save it. We discussed about the origin of Folk Songs, pattern of Folk Songs to clarify the importance of Folk Songs of Chittagong for its connection to Folklore and at the same time for promoting the idea of Nature Conservation. Of course, this part of studies deserves more attention in the field of research. Our ultimate goal should be to conserve and promote Folk Songs of Chittagong with yearlong heritage that automatically will later enrich Folklore and Nature Conservation.

Folklore anecdote between memorata and fabulata: Field research of Serbs in Medina (Hungary

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Ilić Marija

2007-01-01

Full Text Available This work is based on folklore material, which was gathered during ethno linguistic field research of Serbian traditional lexicon and spiritual culture in Medina village in Hungary in 2002. Folklore material is composed of the sayings by the informer Sava Sokic and primarily can be defined as a series of comical narrations. If we look upon these narrations as a genre of oral speech and within context of ethno linguistic interview, we can notice a complex structure of this oral genre. That is, this genre functions as a memorat with typical beginnings and met textual comments. On the other hand, it respects almost all genre norms, which are characteristic for folklore anecdote. Therefore, comic narrations of Save Sokic, and that are valid also for folklore anecdote in general, can be classified as borderline genre - between memorata and fabulata.

′′Early baby teeth′′: Folklore and facts

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N Uma Maheswari

2012-01-01

Full Text Available Variations in the newborns′ oral cavity have been an enduring interest to the pediatric dentist. The occurrence of natal and neonatal teeth is a rare anomaly, which for centuries has been associated with diverse superstitions among many different ethnic groups. Natal teeth are more frequent than neonatal teeth, the ratio being approximately 3:1. The purpose of this case report is to review the literature related to the natal teeth folklore and misconceptions and discuss their possible etiology and treatment.

An Interpretation of Two Oromo Folklore Genres Integrated to ...

African Journals Online (AJOL)

The purpose of this study was to analyze and interpret the meanings of two selected folklore genres namely: riddle and pastoral song portrayed in primary Oromo language student text books integrated to enhance the language skills, knowledge, attitude and cultural values of the children. Qualitative method was employed ...

Dissemination of Values and Culture through the E-Folklore

Science.gov (United States)

Rahim, Normaliza Abd; Affendi, Nik Rafidah Nik Muhammad; Pawi, Awang Azman Awang

2017-01-01

This study focuses on the values and culture in the e-folklore. The objectives of the study were to identify and discuss the values in the song lyric "The Stork and the Mouse Deer." The song was taken from phone application in the compilation of the "Kingfisher stories" copyrighted by Dewan Bahasa and Pustaka. The e-folklore…

Danish TV Christmas calendars: Folklore, myth and cultural history

DEFF Research Database (Denmark)

Agger, Gunhild

2013-01-01

in which this traditional genre has succeeded in renewing itself. The so-called Pyrus series, TV 2’s Christmas calendars during the mid-1990s, exhibited folklore, myth and cultural history in a combination of entertainment and information. They were succeeded by calendars such as Jul i Valhal......This article aims at characterizing the Danish Christmas calendar as a TV institution and a meeting place for the traditions of the almanac, folklore and the history of culture. Against the background of a brief outline of the history of Danish Christmas calendars, the article explores ways...

Tula song folklore: genre-stylistic and dialectic peculiarities

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Krasovskaya Nelli Alexandrovna

2016-06-01

Full Text Available The article analyzes the works of Tula folklore recorded in the western part of the Tula region, in terms of genre, stylistic and linguistic features. The relevance of the study is related to the fact that Tula folk songs has not been studied, linguistic features of the works are not subjected to serious analysis. The article describes the features of the genre of songs recorded in Belevsky district of Tula region, including the ancient fortunetelling chants, wedding ceremony songs, romantic ballads etc., it is cited numerous examples in the lyrics that reflect the dialectal features of the phonetic, grammatical, lexical levels. According to the authors, a modern folk song genre retains its diversity and is a kind of storeroom containing priceless linguistic wealth. The analysis allows to draw conclusions about the presence and well-preserved in the recorded music of South Russian dialect phonetic and grammatical features. So far, there is no established typology of Tula dialects, therefore, according to the authors, the fixation of folklore in the territories bordering on Tula dialects, is very important and interesting for further descriptive and comparative work on identifying the eastern and south-south-west differences in Tula dialects.

The Galileo Legend as Scientific Folklore.

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Lessl, Thomas M.

1999-01-01

Examines the various ways in which the legend of Galileo's persecution by the Roman Catholic Church diverges from scholarly readings of the Galileo affair. Finds five distinct themes of scientific ideology in the 40 accounts examined. Assesses the part that folklore plays in building and sustaining a professional ideology for the modern scientific…

Russian Folklore as a Reflection of National Character in the Work of Boris Vysheslavtzev

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Alex L. Nalepin

2016-09-01

Full Text Available The essay is focused on the spiritual crisis of Russian culture at the beginning of the 20th Century and on the search of philosophical alternatives to overcome the crisis within the framework of Russian philosophical thought. In particular, it highlights the work of Boris P. Vysheslavtzev, a major thinker among Russian immigrants and his studies in Russian folklore seen as reflection of Russian national character. The essay for the first time introduces new data concerning the specificity of the choice that was highly important for Russian literature and culture as it was for Russian folklore studies.

Folklore and Sociolinguistics

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John Holmes McDowell

2018-01-01

Full Text Available Folklore and sociolinguistics exist in a symbiotic relationship; more than that, at points—in the ethnography of communication and in ethnopoetics, for example—they overlap and become indistinguishable. As part of a reaction to the formal rigor and social detachment of Chomsky’s theoretical linguistics, sociolinguistics emerges in the mid-twentieth century to assess the role of language in social life. Folklorists join the cause and bring to it a commitment to in-depth ethnography and a longstanding engagement with artistic communication. In this essay, I trace key phases in the development of this interdisciplinary movement, revolutionary in its reorientation of language study to the messy but fascinating realm of speech usage. I offer the concept of performative efficacy, the notion that expressive culture performances have the capacity to shape attitude and action and thereby transform perceived realities, as a means of capturing the continuing promise of a sociolinguistically informed folkloristics.

KABA MALIN DEMAN: MENYIASATI DAMPAK DUA FALSAFAH MINANGKABAU DALAM FOLKLOR

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Tienn Immerry

2017-11-01

Full Text Available Indonesian folktale is transmitted from one generation to the next by word of mouth. The changes from verbal to written manuscript has in fact undergone a long process. Folktale consists of cultural values of folk/ a particular group of people. Research on folklore is one way to reveal the philosophy contain in the written manuscript. Two of Minangkabau philosophies, extinction philosophy and marriage philosophy, are found in kaba Malin Deman, if imbalance occurs it will create problem in their society. Harmonization is the srategy for the imbalance and also as the function of folklore itself.

Folklore and the Internet: The Challenge of an Ephemeral Landscape1

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Trevor J. Blank

2018-05-01

Full Text Available Through the lens of memetic folk humor, this essay examines the slippery, ephemeral nature of hybridized forms of contemporary digital folklore. In doing so, it is argued that scholars should not be distracted by the breakneck speed in which expressive materials proliferate and then dissipate but should instead focus on the overarching ways that popular culture and current news events infiltrate digital folk culture in the formation of individuals' cultural inventories. The process of transmission and variation that shapes the resulting hybridized folklore requires greater scrutiny and contextualization.

“Stories Like the Light of Stars”: Folklore and Narrative Strategies in the Fiction of Éilís Ní Dhuibhne

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Giovanna Tallone

2017-10-01

Full Text Available Besides being one of Ireland’s best-known and eminent writers, Éilís Ní Dhuibhne is also a professional and recognised folklorist and researcher, whose work covers a diversity of topics and subjects, mostly in the area of the tradition of oral storytelling and urban folklore. Her background in folklore has a relevant impact on her fiction, which is marked by reinvention of folklore patterns and juxtaposition of ancient stories and their contemporary counterpart. The purpose of his essay is to shed light on the impact of folklore and folklore projects on the fiction of Éilís Ní Dhuibhne in terms of in allusions, contents, discourse organization and narrative strategies. The tight link between folklore and storytelling in her writing is analysed taking into account her short stories vis-à-vis her academic work in folklore, focussing on Ní Dhuibhne’s awareness of the continuity of traditional narrative in time.

THE STRUCTURE OF POEM IN TALE KERINCI FOLKLORE

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- Nazurty

2015-06-01

Full Text Available Tale is the folklore in the form of poem that is sung. This study aims to gain in-depth understanding of the structure of Tale poem in the release of the Kerinci pilgrims. This qualitative study employed content analysis as the method with a structural approach. This study discussed the structure of the Tale poem. The results of the study are Tale poem consists of sampiran phrase, the rhyme/ sound phrase, and content. It composed by ten lines to twenty lines. It has ab ab rhyme according to the sound phrase flanking each line. The sound expression serves as rhyme and rhythm former.

Folklore Music on Romanian TV. From State Socialist Television to Private Channels

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Alexandra Urdea

2014-06-01

Full Text Available Music genres rooted in folklore have often been interpreted as ideological manoeuvres to forge a sense of national identity (Gordy, Mihailescu, Baker, Cash. This article explores formalized folklore performances of muzică populară as forms ‘media rituals’ (Couldry, and focuses on the role that television has played in establishing the genre as we know it today. It analyses the link between muzică populară as rooted in mass participation activities during communism, and ‘media rituals’ as framed on television (Couldry, indiscriminately and democratically involving the entire population that it addresses (and is available beyond that.

Folklore Traditions in Contemporary Everyday Life: Between Continuity and (Re)construction (based on two examples from the Czech Republic)

Czech Academy of Sciences Publication Activity Database

Uhlíková, Lucie; Pavlicová, M.

2014-01-01

Roč. 62, č. 2 (2014), s. 163-181 ISSN 1335-1303 Institutional support: RVO:68378076 Keywords : folklore * folklorism * ethno-cultural tradition * social construction * everyday life * the Czech Republic Subject RIV: AC - Archeology, Anthropology, Ethnology

New approaches for development, analyzing and security of multimedia archive of folklore objects

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Galina Bogdanova

2008-07-01

Full Text Available We present new approaches used in development of the demo version of a WEB based client/server system that contains an archival fund with folklore materials of the Folklore Institute at Bulgarian Academy of Sciences (BAS. Some new methods for image and text securing to embed watermarks in system data are presented. A digital watermark is a visible or perfectly invisible, identification code that is permanently embedded in the data and remains present within the data after any decryption process. We have also developed improved tools and algorithms for analyzing of the database too.

Folklore information from Assam for family planning and birth control.

Science.gov (United States)

Tiwari, K C; Majumder, R; Bhattacharjee, S

1982-11-01

The author collected folklore information on herbal treatments to control fertility from different parts of Assam, India. Temporary methods of birth control include Cissampelos pareira L. in combination with Piper nigrum L., root of Mimosa pudica L. and Hibiscus rosa-sinensis L. Plants used for permanent sterilization include Plumbago zeylanica L., Heliotropium indicum L., Salmalia malabrica, Hibiscus rosa-sinensis L., Plumeria rubra L., Bambusa rundinacea. Abortion is achieved through use of Osbeckia nepalensis or Carica papaya L. in combination with resin from Ferula narthex Boiss. It is concluded that there is tremendous scope for the collection of folklore about medicine, family planning agents, and other treatments from Assam and surrounding areas. Such a project requires proper understanding between the survey team and local people, tactful behavior, and a significant amount of time. Monetary rewards can also be helpful for obtaining information from potential respondents.

Differences in motor abilities between dancers in professional and amateur folklore ansambles

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Kocić Jadranka

2014-01-01

Full Text Available Differences in motor abilities between dancers in Serbinan professional folklore ansamble for dance and sing 'Kolo' in Belgrade and amateur folklore ansambles from coulture-arts society 'Vila' and 'Sonja Marinković' from Novi Sad had been tested on sample of 47 members. Motor area was examined by Provincial Governement Institute tests for Sport in Novi sad, and it was received 9 variables: single movement speed, explosivity below extremities (legs, endurance in jumping, absolutely strength backs' flexor muscule, relatively strength backs' flexor muscule, absolutely strength backs' extensor muscule, relatively strength backs' extensor muscule, absolutely strength backs' flexor muscule, relatively strength backs' flexor muscule. Relatively values obtained from absolutely values results using mathemathics. To determine differences between folklore dancers in whole variable system, it was used multivariante analysis variance (MANOVA. It was determined differences between sexes in motor abilities. Data was obtained by statistic packet SPSS 10.0. The aim was to find significant differences in nine mentioned variables between professional and amateur dancers and between sexes. Received results showed that there was not significant differences between professional and amateur dancers. Between sexes it was significant differences in man benefit, except one variable single movement speed. The conclusion is that for better, statisticaly significant results, professional dancers should enlarge contents and expend training intensity.

The Concept of Love in Lithuanian Folklore and Mythology

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Doc dr. Daiva Šeškauskaitė

2013-06-01

Full Text Available Love is a reserved feeling, meaning amiability and complete internecine understanding. The concept of love has always been important for human world outlook and attitude. Love can have different meaning and expression – for some people it is a nice, warm feeling, a way of action and behaviour, for others it is nothing more than a sexual attraction. As there are different perceptions of love, there also exist few common love manifestations: love can be maternal, childish, juvenile, sexual. Love can also be felt for a home land, own nation, home. Naturally love can be expressed through the particular rituals, symbols and signs. Folk songs introduce four main lover characteristics: beauty, sweetness, kindness and boon. The later feature means that a girl/ boy is supposed to be well-set, to be pleasant and comfortable to touch which is very important when choosing a wife or a husband. Love in folklore is expressed through the common metaphorical and allegorical symbols, it doesn‘t sound as explicit word – more like a metaphor or epithet. Love in folklore can be perceived and felt very differently. Love like an action – love like... special person, essential possession. Prime personal characteristics, such as kindness, tenderness, humility, are the ones to light the love fire as well as beauty, artfulness, eloquence also help. Love is supposed to lead to the sacred sacrament of marriage. Love, if real, is a serious subject. Love is worth dying for. Strong love leads to self-sacrifice. Fairy tales satirize infidelity stressing that love is right only between a wife and a husband while other options are considered as inglorious and wrong. Love, as an incest, is also common in our folklore.

Early Years Education and the Value for Money Folklore

Science.gov (United States)

Campbell-Barr, Verity

2012-01-01

This article is intended as a contribution to the debate on the role of human capital in determining value for money in early years education. The article explores how the idea that early years education offers value for money has become folklore amongst policymakers and more widely. However, drawing on both interview data and existing literature…

American Folk Music and Folklore Recordings 1985: A Selected List.

Science.gov (United States)

Library of Congress, Washington, DC. American Folklife Center.

Thirty outstanding records and tapes of traditional music and folklore which were released in 1985 are described in this illustrated booklet. All of these recordings are annotated with liner notes or accompanying booklets relating the recordings to the performers, their communities, genres, styles, or other pertinent information. The items are…

The transformation of contemporary analyses of oral folklore: Fairy tale versus fantasy

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Otčenášek Jaroslav

2010-01-01

Full Text Available The study focuses on contemporary forms of folklore and their relationship to literary forms like Fantasy, Sci-fi, Horror and Fantasy Game. The first problem is the specification of the terms and the classification of the internal structure of these terms. A typical structure of contemporary oral folklore, such as urban legends, is a combination of classical forms of folklore (subject matter from fairy tales, anecdotes etc. and the influence of films, television and books. This contamination is really typical for postmodern culture. Fantasy stories can de divided into five categories - 1. alternative history (variants of past history or future evolution; 2. classical fantasy (variants of mythology or classical fairy tales or legends; 3. parody of fantasy or humour fantasy (the fantasy world is mostly only background; 4. urban fantasy (more or less a part of urban legend; 5. comics (the importance of graphic form - Superman, Batman etc.. Sci-fi and horror stories are mostly literary products influenced by classical legends or urban legends. Party games, especially “Dungeons & Dragons”, and their enactments by fans are a special part of the fantasy world. Ethnologists are faced with the questions of which method to use to carry out field research and what is actually relevant. Based on the first experiences we can see that for the research into this “new” field we can use the standard methods without problems. But for a better understanding we need to read fantasy, sci-fi and horror books, watch fantasy, sci-fi and horror movies, and get acquainted with the websites related to fantasy or sci-fi content. For a good analysis of fantasy party games one needs to become a member of a gamers’ group. The use of modern recording equipment like digital video cameras and cameras etc. is also very important.

"Haunting experiences: Ghosts in contemporary folklore," by Diane E. Goldstein et al.

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Linda Levitt

2010-03-01

Full Text Available Diane E. Goldstein, Sylvia Ann Grider, and Jeannie Banks Thomas. Haunting experiences: Ghosts in contemporary folklore. Logan: Utah State University Press, 2007, paperback, $24.95 (272p ISBN 978-0-87421-636-3.

Folklore, creativity, and cultural memory

DEFF Research Database (Denmark)

Glaveanu, Vlad Petre

the role of tradition and creativity in the life of a rural community. Egg decoration is an old custom, with pre-Christian roots, practiced extensively in the historical region of Bucovina, and relying on a complex system of material artefacts and symbolic elements acquired and enacted by artisans usually...... means the opposite of creativity but the actual vehicle of creative activity and its understanding as a stable cultural system ‘engraved’ in collective memory needs to be challenged. The tradition of egg decoration in Romania is a living and evolving social practice that engages the self and community......This paper addresses the question of how folk art can be, simultaneously, a vehicle for cultural memory and cultural creativity. It takes the case of Romanian Easter egg decoration as a practice situated at the intersection between art, folklore, religion and a growing market, it order to unpack...

From Folklore to Scientific Evidence: Breast-Feeding and Wet-Nursing in Islam and the Case of Non-Puerperal Lactation

Science.gov (United States)

Moran, Lia; Gilad, Jacob

2007-01-01

Breast-feeding practice has an important medical and socio-cultural role. It has many anthropological aspects concerning the “power structures” that find their expression in breast-feeding and the practices that formed around it, both socially, scientifically, and legally-speaking. Breast-feeding has been given much attention by religions and taboos, folklore, and misconception abound around it making it a topic of genuine curiosity. This paper aims at expanding the spectrum of folklore associated with breast-feeding. The paper deals with historical, religious, and folkloristic aspects of breast-feeding, especially wet-nursing, in Islam and focuses on an intriguing Islamic tale on breast-feeding - lactation by non-pregnant women (or non-puerperal lactation). Apparently, accounts of non-puerperal lactation are not restricted to Islam but have been documented in various societies and religions throughout centuries. Two medical situations - hyperprolactinemia and induced lactation, appear as possible explanations for this phenomenon. This serves as an excellent example for the value of utilizing contemporary scientific knowledge in order to elucidate the origin, anthropology and evolvement of ancient myth and superstition. PMID:23675050

IDEOLOGICAL APPROACHES OF FOLKLORE STUDIES IN KYRGYZSTAN ON THE SOVIET UNION PERIOD: ERSOLTONOY EPIC EXAMPLE SOVYETLER BİRLİĞİ DÖNEMİNDE KIRGIZİSTAN’DA FOLKLOR ÇALIŞMALARINDA İDEOLOJİK YAKLAŞIMLAR: ER SOLTONOY DESTANI ÖRNEĞİ

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Mehmet ÇERİBAŞ

2012-01-01

Full Text Available Folklore, emerged in the 19th century with the romance movement as a tool of nationalizm, acted as shield aganist discriminative movements in the countries which weren’t able to achieve political unity. Political movement, which doesn’t consist freedom of expression and based on single party system like socialism, nazism and communism, wanted to take advantage of all communication channels for propaganda purpose. These movements imposed important folklore products which was considered as a means of communication and interaction. One of these is to understand the judgements values and develop policies on this judgements, other is to ensure harmony between the regime and people-more clearly by formatting fort he purpose of regime.Socialism which is of the movements using folklore for the ideological purpose have benefited from folklore to make people of occupied countries for he emperialist purpose compatible. Epic type, decorated with elements of romantics and nationalism, is used to increase nationalism by the Turks tribes where oral culture is dominant during the war period at ordinary times has taken spokemanship of proletariat class. Such work has been tested on the Kyrgyz Turks which were nomadic horseman and interested in the type of epic proceeding from Er Soltonoy’s of Kyrgyz Turks. 19. yüzyılda ortaya çıkan romantizm hareketiyle uluslaşmanın bir aracı olarak görülen folklor ürünleri, siyasi birliğini sağlayamamış ülkeler tarafından dıştan gelecek ayrıştırıcı akımlara karşı kalkan görevini görmüştür. Nazizm, Sosyalizm ve Komünizm gibi tek parti sistemine dayanan ve ifade özgürlüğünün olmadığı siyasi akımlar ise halka ulaşabilecekleri bütün iletişim kanallarından propaganda amacıyla yararlanmak istemişler; bu akımlar dönemin iletişim araçlarından sayılan folklor ürünlerine de bu bağlamda önemli görevler yüklemişlerdir. Bu görevlerden biri, halkın değer yarg

Folklore as historical and cultural legasy of the lower Volga region in the first third of the XXth century: B.S. Laschilin, A.M. Listopadov

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Rodionova Olga Igorevna

2013-11-01

Full Text Available In the present article the question of the folklore phenomenon in the folk art of the Lower Volga Region in the first third of the 20th century is considered. In the course of research high emphasis was placed on the Cossack subject matter. The role of B.S. Laschilin and A.M. Listopadov in collecting and publishing folk art, the folklore of the Don Cossacks, is revealed. Boris Stepanovitch Laschilin’s work left a great impact in the artistic life of our region. In B.S. Laschilin’s books, that were published in Rostov-on-Don, Saratov, Stalingrad-Volgograd, contained tales, fairy tales, bylinas, legends, songs, ditties, proverbs, sayings, ancient dramas of the first Russian folk theatres, exorcisms. Boris Stepanovitch kept selecting songs and ditties, chastooshkas for Voronezh Folk Choir “Voronezh girls”, which are still in the repertoire of the Pyatnitsky Russian Folk Chorus. Folklorist and musician Alexander Mikhailovich Listopadov, who collected and studied folk songs from his youth up, and recorded them in the Don Region hamlets and Cossack villages, spent more than 50 years of his life on the research of the Don Cossack’s musical culture. Alexander Mikhailovich Listopadov’s heritage made an important contribution to the native musical folklore study. Folklore compositions is a unique source of knowledge of history, way of life, moral and other national concepts, which allows us to reconstitute a linguistic personality of a definite historical epoch.

“The Foresight to Become a Mermaid”: Folkloric Cyborg Women in Éilís Ní Dhuibhne’s Short Stories

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Rebecca Graham

2017-10-01

Full Text Available Éilís Ní Dhuibhne is both a folklorist and a feminist, who “took an interest in rewriting or re-inventing women’s history, a history which had been largely unwritten” (Ní Dhuibhne, “Negotiating” 73. Folklore stories and motifs abound in her writing. Elke D’hoker argues that Ní Dhuibhne reimagines and rewrites folktales to “reflect and interpret the social values and attitudes of a postmodern society” (D’hoker 137. The repurposing of folklore allows Ní Dhuibhne to interrogate some of the complex and controversial ways that Irish society has attempted to represent and control women, entrenching taboos about female behaviours and sexualities. Using Donna Haraway’s cyborg feminism and Karen Barad’s deployment of Haraway’s theory of diffraction, this article focuses on issues of voice and orality, and the female body in “The Mermaid Legend”, “Midwife to the Fairies”, and “Holiday in the Land of Murdered Dreams”, to argue that Ní Dhuibhne’s repurposing of folklore is a radically feminist undertaking. All three short stories, which feature female protagonists, reveal diverse, transgressive, sexual mothers and maidens whose symbolic connections with folklore allow them to challenge the restrictive constructions of women in Irish society, creating spaces to explore alternative, heterogeneous, feminist re-conceptions of identity and belonging.

Vodú Chic: Haitian Religion and the Folkloric Imaginary in Socialist Cuba

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Grete Viddal

2012-12-01

Full Text Available During the first three decades of the twentieth century, hundreds of thousands of Haitian agricultural laborers arrived in Cuba seeking employment in the expanding sugar industry. Historically, Haitian cane cutters were marginal and occupied the lowest socio-economic status in Cuban society. Until relatively recently, the maintenance of Haitian spiritual beliefs, music, dance, and language in Cuba were associated with rural isolation and poverty. Today however, the continuation of Haitian customs is no longer linked with isolation, but exactly the opposite: performance troupes, heritage festivals, art exhibitions, the circulation of religious specialists, collaborations with research centers and academia, endorsement by music promoters, and the tourism industry. Cubans of Haitian heritage have found innovative ways to transform the abject into the exotic, and are currently gaining a public voice in cultural production, particularly through folkloric performance.

[Folklore and popular medicine in the Amazon].

Science.gov (United States)

Henrique, Márcio Couto

2009-01-01

This discussion of the relations between folklore and popular medicine in the Amazon takes Canuto Azevedo's story "Filhos do boto" (Children of the porpoise) as an analytical reference point. Replete with elements of cultural reality, folk tales can serve as historical testimonies expressing clashes between different traditions. Folk records are fruit of what is often a quarrelsome dialogue between folklorists, social scientists, physicians, and pajés and their followers, and their analysis should take into account the conditions under which they were produced. Based on the imaginary attached to the figure of the porpoise--a seductive creature with healing powers--the article explores how we might expand knowledge of popular medicine as practiced in the Amazon, where the shamanistic rite known as pajelança cabocla has a strong presence.

El narco-folklore: narrativas e historias de la droga en la frontera

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Howard Campbell

2007-01-01

Full Text Available Lo que el gobierno de los Estados Unidos ha llamado “La guerra contra las drogas” se basa en la idea de que el consumo y tráfi co de estupefacientes son inequívocamente actividades dañinas y peligrosas que la población del país temerá y rechazará. No obstante, los resultados de estudios etnográfi cos en la frontera Estados Unidos- México indican que el tráfi co de drogas se ha convertido en una actividad tan común que ha generado su propio estilo de subcultura, incluyendo música y folklore. Hasta la fecha los estudios antropológicos de la narco-cultura en la frontera se han enfocado en los narcocorridos, un género de música mexicana popular que celebra y narra el comercio de los estupefacientes y las vidas de trafi cantes de alto nivel. Estos estudios proporcionan perspectivas valiosas sobre los funcionamientos internos de las organizaciones de la droga y del contexto cultural de los cuales emergen. Sin embargo, la mayoría de los trabajadores del narcotráfi co no son los superhéroes o los bandidos ricos retratados en los narcocorridos. Es el pueblo, que tiene como principal motivación para involucrarse en el mundo de los estupefacientes la supervivencia económica. La imagen de un rico folklore de tráfi co de drogas se ha convertido en un perfi l común en la región fronteriza de El Paso / Ciudad Juárez. Este estudio etnográfi co muestra cómo este comercio se ha convertido en una parte “normal” de la vida diaria. El folklore cotidiano alrededor del tráfi co de drogas indica el grado en el cual el comercio de éstas afecta a los habitantes de la frontera en múltiples niveles.

La aldea fantasma: Problemas en el estudio del folklore y la cultura popular contemporáneos

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Díaz G. Viana, Luis

2003-06-01

Full Text Available The author analyzes the problems involved in the study of folklore and popular culture in a contemporary world, transnational and hybrid, aparently different from what the object/subject of study was supposed to be. Nevertheless he argues that the type of urban legends we can gather today through Internet does not differe from the traditional materials, such as leyends, games or mores, since they talk (as they used to about people tryng to make sense out of an always changing and mixed world.

El autor ofrece un análisis de la problemática relacionada con el estudio del folklore y la cultura popular en el mundo contemporáneo, transnacional e híbrido, aparentemente distinto de lo que se suponía que era el objeto/sujeto de estudio tradicional. Sin embargo, argumenta que el tipo de leyendas urbanas que podemos recopilar hoy a través de internet no es diferente de los materiales tradicionales, tales como leyendas, juegos o costumbres; ya que de lo que hablan éstos, al igual que aquéllos, es de las preocupaciones de las personas por dar sentido a un mundo siempre cambiante y siempre en contacto.

“Not a Thing of the Past”, Zora Neale Hurston and the Living Legacy of Folklore « Not a Thing of the Past », Zora Neale Hurston et le legs vivant du folklore

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Margaret Gillespie

2009-11-01

Full Text Available Auteur important bien qu’atypique de la Renaissance de Harlem et premier anthropologue afro-américain à avoir étudié sa propre culture, Zora Neale Hurston est, à de nombreux titres, un écrivain d’exception. Contrairement à d’autres, dont Robert Wright et Alain Locke, Hurston ne renie nullement le legs culturel que représente le folklore noir qu’elle apprécie selon ses propres critères, folklore qui influencera tant la forme que le fond de son art. Anthropologue de formation, Hurston appréhende néanmoins la culture noire américaine du sud non pas comme un vestige du passé qu’il conviendrait de conserver précieusement intact, mais comme une partie intégrante du vécu actuel. À travers les stratégies discursives orales vernaculaires qu’elle adopte et adapte de la tradition folklorique afro-américaine, Hurston, en pionnière, ouvre une voie et donne une voix aux écrivains Noirs à venir.

The development of folklore, arts and crafts in ukrainian ethnic minorities: trends (1990 – 2000-s)

OpenAIRE

V. M. Pekarchuk

2014-01-01

On the basis of represented wide palette of historical facts, analytic works, scientific documents it is made an attempt to reproduce the place and role of folklore, arts and crafts of Ukrainian ethnic minority cultures within 1990 ­ 2000 ­ ies. The importance of the designated problem is caused, first of all, the need to have a clear understanding of the mechanism of the decision problem of an independent state of interethnic relations. It was found that during the study years in Ukraine,...

Pre-Modern Bosom Serpents and Hippocrates' Epidemiae 5: 86: A Comparative and Contextual Folklore Approach

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Davide Ermacora

2016-03-01

Full Text Available A short Hippocratic passage (Epidemiae 5: 86 might constitute the earliest Western surviving variant of the well-known narrative and experiential theme of snakes or other animals getting into the human body (motif B784, tale-type ATU 285B*. This paper aims: 1 to throw light on this ancient passage through a comparative folkloric analysis and through a philological-contextual study, with reference to modern and contemporary interpretations; and 2 to offer an examination of previous scholarly enquiries on the fantastic intrusion of animals into the human body. In medieval and post-medieval folklore and medicine, sleeping out in the field was dangerous: snakes and similar animals could, it was believed, crawl into the sleeper’s body through the ears, eyes, mouth, nostrils, anus and vagina. Comparative material demonstrates, meanwhile, that the thirsty snake often entered the sleeper’s mouth because of its love of milk and wine. I will argue that while Epidemiae 5: 86 is modelled on this long-standing legendary pattern, for which many interesting literary pre-modern (and modern parallels exist, its relatively precise historical and cultural framework can be efficiently analysed. The story is embedded in a broad set of Graeco-Roman ideas and practices surrounding ancient beliefs about snakes and attitudes to the drinking of unmixed wine.

Mergelės Marijos ir akmens sąsajos lietuvių folklore

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Kairaitytė, Aušra

2008-01-01

The object of this article is the relation between stone and the Blest Virgin Mary. The aim is to define the functions of stone in narratives about the Mother of God in the Lithuanian folklore, revealing the place of stone during the advent of Mary and finding parallels in the tradition of different Catholic countries. The aim is achieved by applying text analysis and comparative methods. Lithuanian folk stories tell us about growing or walking stones. [...] The other group consists of storie...

When phonetics matters: creation and perception of female images in song folklore

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Stashko Halyna

2017-06-01

Full Text Available This paper presents a stylistic analysis of female images in American song folklore in order to examine how sound symbolic language elements contribute to the construction of verbal images. The results obtained show the link between sound and meaning and how such phonetic means of stylistics as assonance, alliteration, and onomatopoeia function to reinforce the meanings of words or to set the mood typical of the characters. Their synergy helps create and interpret female images and provides relevant atmosphere and background to them in folk song texts.

Rileggendo “Folklore e profitto”. Patrimoni immateriali, mercati, turismo

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Letizia Bindi

2014-04-01

Full Text Available Starting from the anticipatory notes of Luigi M. Lombardi Satriani’s Folklore e profitto [1973], the paper seeks to critically articulate the interesting relation between cultural heritage, capitalistic market and mass media, updating the analysis, also, to the most recent forms of the use of media in promoting and valorizing such traditions. What emerges is a twist of cultural heritage toward consumerism that imposes to anthropologists and cultural heritage scholars new challenges and questions and a late-modern rethinking of critical categories as commodification, alienation and fetishization. A central question, finally, arises about who and what should be today the social actors asked to decide about these processes of cultural manipulation in the new post-industrial and globalized scenario, characterized, inter alia, from a generalized economic crisis. 

ROMANIAN FOLKLORE MOTIFS IN FASHION DESIGN

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MOCENCO Alexandra

2014-05-01

Full Text Available The traditional Romanian costume such as the entire popular art (architecture, woodcarvins, pottery etc. was born and lasted in our country since ancient times. Closely related to human existence, the traditional costume reflected over the years as reflected nowadays, the mentality and artistic conception of the people. Today the traditional Romanian costume became an inspiration source to the wholesale fashion production industry designers, both Romanian and international. Although the contemporary designers are working in accordance with a vision, using a wide area of styles, methods and current technology, they usually return to traditional techniques and ethnic folklore motifs, which converts and resize them, integrating them in their contemporary space. Adrian Oianu is a very appreciated Romanian designer who launched two collections inspired by his native’s country traditional costumes: “Suflecata pan’ la brau” (“Turned up ‘til the belt” and “Bucurie” (“Joy”. Dorin Negrau had as inspiration for his “Lost” collection the traditional costume from the Bihor region. Yves Saint Laurent had a collection inspired by the Romanian traditional flax blouses called “La blouse roumaine”. The paper presents the traditional Romanian values throw fashion collections. The research activity will create innovative concepts to support the garment industry in order to develop their own brand and to bring the design activities in Romania at an international level. The research was conducted during the initial stage of a project, financed through national founds, consisting in a documentary study on ethnographic characteristics of the popular costume from different regions of the country.

'DELİ DUMRUL' BY SUAT TAŞER, WITHIN THE SCOPE OF FOLKLORE - IDEOLOGY – LITERATURE FOLKLOR-İDEOLOJİ-EDEBİYAT ÜÇGENİNDE SUAT TAŞER’İN DELİ DUMRUL’U

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Nezir TEMUR

2011-12-01

Full Text Available It's a sociologically inevitable phenomenon that the social andpolitical changes occuring in societies evoke their reflections in culturalproductions prominently. Since the 19th Century, when nationalidentities began to take form along with romantic nationalism, folkloricartifacts which are significant conveyers of cultural recollections such ashistory and language, have confronted us as a field emphasized byideological and literary movements, notably Social Sciences. In the worldof 20th Century, when ideologies began to take form in political sense,folkloric artifacts undertook significant functions in culture policiesenvisaged by dominant ideologies for the new forms of Societies whichthey tried to build. The style of the folkloric artifacts, cultural codes theyconveyed, and their functionality have been active components in thisapproach. In this sense, the intensifying process , which begins to headtowards works of folk narrations, folk poetry, and folk literature inTurkish Literature after 1930s, gradually increases after the 1940s andthis tendency becomes one of the significant sources fostering literature.At this point, substantial works of Turkish folklore such as epics,folktales, tales, legends have been released to the public within newperspectives and techniques.It can be seen that new pursuits in expressions and utteranceshave been embarked, like in 'Deli Dumrul - Ölüm ve Aşk' (Epic and Playby Dede Korkut , which can be considered as the rewriting of one of hisepics with a new understanding. This study aims to make a comparisonbetween 'Deli Dumrul - Ölüm ve Aşk' (Epic - Play by Suat Taşer and theoriginal text of the Epic of Deli Dumrul and to examine how folkloricartifacts and cultural values tried to be transmitted into those artifactshave been modernized, adapted contemporarily and released ;the partswhere the writer digressed from the souce text during the adaptation; towhat extent the traditional context has been changed

Folklore and traditional ecological knowledge of geckos in Southern Portugal: implications for conservation and science

Science.gov (United States)

2011-01-01

Traditional Ecological Knowledge (TEK) and folklore are repositories of large amounts of information about the natural world. Ideas, perceptions and empirical data held by human communities regarding local species are important sources which enable new scientific discoveries to be made, as well as offering the potential to solve a number of conservation problems. We documented the gecko-related folklore and TEK of the people of southern Portugal, with the particular aim of understanding the main ideas relating to gecko biology and ecology. Our results suggest that local knowledge of gecko ecology and biology is both accurate and relevant. As a result of information provided by local inhabitants, knowledge of the current geographic distribution of Hemidactylus turcicus was expanded, with its presence reported in nine new locations. It was also discovered that locals still have some misconceptions of geckos as poisonous and carriers of dermatological diseases. The presence of these ideas has led the population to a fear of and aversion to geckos, resulting in direct persecution being one of the major conservation problems facing these animals. It is essential, from both a scientific and conservationist perspective, to understand the knowledge and perceptions that people have towards the animals, since, only then, may hitherto unrecognized pertinent information and conservation problems be detected and resolved. PMID:21892925

Folklore and traditional ecological knowledge of geckos in Southern Portugal: implications for conservation and science

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Vila-Viçosa Carlos M

2011-09-01

Full Text Available Abstract Traditional Ecological Knowledge (TEK and folklore are repositories of large amounts of information about the natural world. Ideas, perceptions and empirical data held by human communities regarding local species are important sources which enable new scientific discoveries to be made, as well as offering the potential to solve a number of conservation problems. We documented the gecko-related folklore and TEK of the people of southern Portugal, with the particular aim of understanding the main ideas relating to gecko biology and ecology. Our results suggest that local knowledge of gecko ecology and biology is both accurate and relevant. As a result of information provided by local inhabitants, knowledge of the current geographic distribution of Hemidactylus turcicus was expanded, with its presence reported in nine new locations. It was also discovered that locals still have some misconceptions of geckos as poisonous and carriers of dermatological diseases. The presence of these ideas has led the population to a fear of and aversion to geckos, resulting in direct persecution being one of the major conservation problems facing these animals. It is essential, from both a scientific and conservationist perspective, to understand the knowledge and perceptions that people have towards the animals, since, only then, may hitherto unrecognized pertinent information and conservation problems be detected and resolved.

Conservation Implications of the Prevalence and Representation of Locally Extinct Mammals in the Folklore of Native Americans

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Preston Matthew

2009-01-01

Full Text Available Many rationales for wildlife conservation have been suggested. One rationale not often mentioned is the impact of extinctions on the traditions of local people, and conservationists′ subsequent need to strongly consider culturally based reasons for conservation. As a first step in strengthening the case for this rationale, we quantitatively examined the presence and representation of eight potentially extinct mammals in folklore of 48 Native American tribes that live/lived near to 11 national parks in the United States. We aimed to confirm if these extinct animals were traditionally important species for Native Americans. At least one-third of the tribes included the extinct mammals in their folklore (N=45 of 124 and about half of these accounts featured the extinct species with positive and respectful attitudes, especially the carnivores. This research has shown that mammals that might have gone locally extinct have been prevalent and important in Native American traditions. Research is now needed to investigate if there indeed has been or might be any effects on traditions due to these extinctions. Regardless, due to even the possibility that the traditions of local people might be adversely affected by the loss of species, conservationists might need to consider not only all the biological reasons to conserve, but also cultural ones.

Conservation Implications of the Prevalence and Representation of Locally Extinct Mammals in the Folklore of Native Americans

OpenAIRE

Preston Matthew; Harcourt Alexander

2009-01-01

Many rationales for wildlife conservation have been suggested. One rationale not often mentioned is the impact of extinctions on the traditions of local people, and conservationists′ subsequent need to strongly consider culturally based reasons for conservation. As a first step in strengthening the case for this rationale, we quantitatively examined the presence and representation of eight potentially extinct mammals in folklore of 48 Native American tribes that live/lived near to 11 n...

1970 MLA Abstracts of Articles in Scholarly Journals, Volume I: General, English, American, Medieval and Neo-Latin, Celtic Literatures; and Folklore.

Science.gov (United States)

Fisher, John H., Comp.; Achtert, Walter S., Comp.

The first volume of an annual series following the arrangement of the "MLA International Bibliography" includes sections on General, English, American, Medieval and Neo-Latin, Celtic literatures, and Folklore. A classified collection of 1,744 brief abstracts of journalarticles on the modern languages and literatures to be used in conjunction with…

When “She” Is Not Maud: An Esoteric Foundation and Subtext for Irish Folklore in the Works of W.B. Yeats

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C. Nicholas Serra

2017-10-01

Full Text Available This article examines Yeats’s broad use of Irish folklore between 1888 and 1938, and attempts to find a justification for his contention that his own unique metaphysical system expressed in both editions of A Vision, itself an outgrowth of his three decades of ritual practice as an initiate in the Hermetic Order of the Golden Dawn, could somehow function as both an interpretation and enlargement of “the folk-lore of the villages”. Beyond treating Irish fairy stories as a way for Yeats to establish his own Irishness, capture what remained of “reckless Ireland” in its twilight, or create a political counter-discourse set against English hegemony, the immutability and immortality of the sídhe are considered in light of the assertions of several minor lectures from the Golden Dawn. This connection sheds new light on Yeats’s ideas about Unity of Being, and hypothesizes a possible esoteric path to “escape” from his system of phases so as to resolve the body-soul dilemma evident in his poetry.

The Folklore - Nationalism Relationship in the Balkans. Case Study “Whose Is This Song?” by Adela Peeva

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Elena-Lorena Nedelcu

2016-06-01

Full Text Available This article analyses a 2003 documentary titled “Whose Is This Song?” by Bulgarian movie director Adela Peeva, in the purpose of understanding the relationship between the folklore and the nationalism in the Balkans. The theme of the documentary is the director’s quest to trace the roots of a folk song that she had thought was 100 percent Bulgarian since her childhood. The documentary follows Peeva’s journey with a camera in hand around Turkey, Greece, Macedonia, Albania, Bosnia and Herzegovina, Serbia and Bulgaria, where she discovers that the song is sung by all of these nations. The documentary can be interpreted as showing how an ordinary song could become an instrument of fanatical nationalism and that it reveals mutual strife instead of Balkan unity. In a region defined by ethnic hatred and war, what begins as a simply investigation of the true origins of a song, ends as a sociological and historical exploration of the deep misunderstandings between the people of the Balkans.

Declaraciones patrimoniales, turismo y conocimientos locales: Posibilidades de los estudios del folklore para el caso de las ferias en la quebrada de Humahuaca (Jujuy-Argentina Patrimony Statements, Tourism and Local Knowledge: Folklore Studies Posibilities in Quebrada de Humahuaca Fairs Case (Jujuy - Argentina

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Liliana Bergesio

2010-12-01

look its own alternatives to attract visitors. The most common strategies include fairs and festivals seeking to highlight particular characteristics. In this study we will analize the case of Coctaca town (Humahuaca department, and also an eventa being done there in febraury, wich includes "Flavors of History" fair, the "Andean Women Meeting", and the "Serenade to the Cultivation Terraces". The objective of this study is to raise the possibilities that studies of folklore provide inside topis as the local and the global, culture and economy, the producers and their products and tourism with its demands and expectations.

Sleep paralysis in Brazilian folklore and other cultures: a brief review

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José Felipe Rodriguez de Sá

2016-09-01

Full Text Available Sleep paralysis (SP is a dissociative state that occurs mainly during awakening. SP is characterized by altered motor, perceptual, emotional and cognitive functions, such as inability to perform voluntary movements, visual hallucinations, feelings of chest pressure, delusions about a frightening presence and, in some cases, fear of impending death. Most people experience SP rarely, but typically when sleeping in supine position; however, SP is considered a disease (parasomnia when recurrent and/or associated to emotional burden. Interestingly, throughout human history, different peoples interpreted SP under a supernatural view. For example, Canadian Eskimos attribute SP to spells of shamans, who hinder the ability to move, and provoke hallucinations of a shapeless presence. In the Japanese tradition, SP is due to a vengeful spirit who suffocates his enemies while sleeping. In Nigerian culture, a female demon attacks during dreaming and provokes paralysis. A modern manifestation of SP is the report of alien abductions, experienced as inability to move during awakening associated with visual hallucinations of aliens. Furthermore, SP is a significant example of how a specific biological phenomenon can be interpreted and shaped by different cultural contexts. In order to further explore the ethnopsychology of SP, the Pisadeira, a character of Brazilian folklore originated in the country’s Southeast, but also found in other regions with variant names, has been reviewed. Pisadeira is described as a crone with long fingernails who lurks on roofs at night and tramples on the chest of those who sleep on a full stomach with the belly up. This legend is mentioned in many anthropological accounts; however, we found no comprehensive reference on the Pisadeira from the perspective of sleep science. Here we aim to fill this gap. We first review the neuropsychological aspects of SP, and then present the folk tale of the Pisadeira. Finally, we summarize the

The search for novel anticancer agents: a differentiation-based assay and analysis of a folklore product.

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Dinnen, R D; Ebisuzaki, K

1997-01-01

One alternative approach to the current use of cytotoxic anticancer drugs involves the use of differentiation-inducing agents. However, a wider application of this strategy would require the development of assays to search for new differentiation-inducing agents. In this report we describe an in vitro assay using the murine erythroleukemia (clone 3-1) cells. Tests for the efficacy of this assay for the analysis of antineoplastic activity in natural products led to studies on pau d'arco, a South American folklore product used in the treatment of cancer. Purification of the activity in aqueous extracts by solvent partition and thin layer chromatography (TLC) indicated the presence of two activities, one of which was identified as lapachol. The activity in the pau d'arco extracts and of lapachol was inhibited by vitamin K1. As a vitamin K antagonist, lapachol might target such vitamin K-dependent reactions as the activation of a ligand for the Axl receptor tyrosine kinase.

Transformation of folklore tradition in the poem by M.I. Tsvetaeva “From the Sea”

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Galieva Marianna Andreevna

2015-06-01

Full Text Available The paper studies the functioning of the folk tradition in the poetics by M.I. Tsvetaeva. The object of research is the poem “From the Sea” of 1926. Scientists have carefully studied motivic structure of the poem, but the attention is not paid to the folk elements. Special attention is paid to the motive of travel to “the other world”, which in terms of the semantics is correlated with the motive of sleep. Folklorism creativity of M.I. Tsvetaeva is studied enough, but there is always a need for the identification of implicit forms of folk traditions that exist in the poetics. In our work we are talking about the breaking of the folk tradition, its inner form. The connection to the archetypal models of poetry (the ship by pre-genre formations. Appeal to the fabulous tradition, to the motif of travel to “the other world” shows the archetypal, not typical in the poetry of the early XX century. It is applied the historical and typological method; Tsvetaeva’s metaphor is genetically traced to the ritual of reality expressed in the plot structure of the ship, eydology of the “other kingdom”. Historical poetics allows look at the poem “From the Sea” differently.

1970 MLA International Bibliography of Books and Articles on the Modern Languages and Literatures, Volume I: General, English, American, Medieval and Neo-Latin, Celtic Literatures; and Folklore.

Science.gov (United States)

Meserole, Harrison T., Comp.

Volume 1 of the four-volume, international bibliography contains over 11,140 entries referring to books, Festschriften, analyzed collections, and articles which focus on General, English, American, medieval and neo-Latin, and Celtic literatures. A section of folklore is also included. The section on general literature includes: (1) aesthetics, (2)…

The specificity of folklore and mythological motifs in the novel “Tsar Maiden” by Vsevolod Solovyov

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Lyapina Svetlana Mitrofanovna

2014-12-01

Full Text Available The article deals with folklore motifs in the novel by Vsevolod Solovyov “Tsar-maiden”, and reveals the link between this work and a magic tale. The author comes to the conclusion that the appeal to the image of the Tsar-maiden due to the desire of the writer to show the irrational spirit of pre-Petrine Russia, judgment of the people of the rulers of Imperial power. In the popular view of the nation the fact that the woman has become a monarch it was beyond their comprehension and considered a miracle akin to a fairy tale. Therefore, from Vsevolod Solovyov’s viewpoint, a fabulous image of the Tsar-maiden in the minds of the people coincided with the image of Princess Sophia.

Plant derived substances with anti-cancer activity: from folklore to practice

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Marcelo eFridlender

2015-10-01

Full Text Available Plants have had an essential role in the folklore of ancient cultures. In addition to the use as food and spices, plants have also been utilized as medicines for over 5000 years. It is estimated that 70-95% of the population in developing countries continues to use traditional medicines even today. A new trend, that involved the isolation of plant active compounds begun during the early 19th century. This trend led to the discovery of different active compounds that are derived from plants. In the last decades, more and more new materials derived from plants have been authorized and subscribed as medicines, including those with anti-cancer activity. Cancer is among the leading causes of morbidity and mortality worldwide. The number of new cases is expected to rise by about 70% over the next 2 decades. Thus, there is a real need for new efficient anti-cancer drugs with reduced side effects, and plants are a promising source for such entities. Here we focus on some plant-derived substances exhibiting anti-cancer and chemoprevention activity, their mode of action and bioavailability. These include paclitaxel, curcumin and cannabinoids. In addition, development and use of their synthetic analogs, and those of strigolactones, are discussed. Also discussed are commercial considerations and future prospects for development of plant derived substances with anti-cancer activity.

Folklore motives in the early compositions of Nikola Borota - Radovan

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Jovanović Jelena

2014-01-01

Full Text Available The creative work of Nikola Borota - Radovan (musician, composer, lyricist, arranger and record producer, based in New Zealand - formerly from Yugoslavia held a specific place in development of world music (polygenre in his native homeland in the early 1970s. This study focuses on his creative principles, applied to works published between the years 1970 and 1975 (while the role of these works in social, cultural and political context of the time and place will be elaborated in another study, see Jovanović 2014. The platform established to present this unique musical approach authenticaly was called kamen na kamen (a studio and stage outfit that has included number of collaborations over many years. Based on the musical models and aethetics of the folk revival and created under influence of The Beatles’, in adition to many other popular music production directions of the era, Borota’s works reveal significant musical, performance and production qualities, innovative expression and musical solutions, that need to be percieved from the contemporary (ethnomusicological point of view. Despite the fact that many prominent creative Yugoslav musicians of the time also worked within a similar framework I would argue that Mr. Borota’s creative outcome was signifficantly different from other Yugoslav popular music creative efforts. This is particularly noticeable in the author’s unique treatment of South-European and other folklore motives, which is the main topic of this study. Folk (ethnic idioms exploited by Mr. Borota in his compositions originate from the rural traditions of western Dinaric regions. This is especially true for the rhythmic formations of deaf or silent dance; for the semi-urban and urban tradition of the Balkans and the Mediterranean; Middle European traditions; traditions from non-European peoples; elements of Italian Renaissance; and international (mostly Anglo-American musical models. Compositions are analysed partly in

Ande-Ande Lumut: Adaptasi Folklor ke Teater Epik Brecht

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Philipus Nugroho Hari Wibowo

2013-11-01

and Japan. The adaptation theory is developing well; everything can be used as an adaptation object, poems, novels, dramas, paintings, dances, and video games. Kemuning is performed by the performing concept of Brecht’s epic theater. However, this is an effort to fi nd out the new form of reading in Ande-Ande Lumut story. The epic theater against one of the main elements in Aristotle’s drama that has been developed by Stanislavsky’s method; there should be an empathy in every aspect of performance. According to Brecht, this process has caused an effect which should be avoided because it brings audience’s passive attitude. Therefore, he tried to make a theory of destroying the illusion, of interrupting method, and of controlling emotion. Brecht’s identical works focus on the social themes, especially on the themes that show the poor people who are suffering from the authority’s policy. The common problems between the master and its worker are refl ected on hisstory. The Kemuning performance has tried to show the prostitutes’ life that is closed to any negative things. In fact, they are still being needed by the society. Unfortunately, sometimes they become the source of scapegoats to any troubles and are always blamed to. Implicitly, this performance is aimed to fi ght for the prostitutes’ life. The audience is invited to see the other points of view about their life that are often regarded as negative by the people. Moreover, Brecht said that a good and demanded theater in this modern era is a theater that can arouse the audience’s critical thinking activities. Therefore, this performance is supposed to be able to motivate the arts lovers in producing a critical analysis to any social awareness and in creating a new movement to any signifi cant changes in society. Keywords: Folklore, Ande-Ande Lumut, Adaptation, and Brecht’ Epic Theater

"Old Oxen Cannot Plow": Stereotype Themes of Older Adults in Turkish Folklore.

Science.gov (United States)

Marcus, Justin; Sabuncu, Neslihan

2016-12-01

Although much research has established the nature of attitudes and stereotypes toward older adults, there are conflicting explanations for the root cause of ageism, including the sociocultural view and interpersonal views, that age bias against older adults is uniquely a product of modernity and occurs through social interactions, and the evolutionary view and intraindividual views, that age bias against older adults is rooted in our naturally occurring and individually held fear of death. We make initial investigations into resolving this conflict, by analyzing literature from a society predating the Industrial Revolution, the society of Ottoman Turks. Using Grounded Theory, we analyzed 1,555 Turkish fairy tales of the most well-known older adult in Turkish folklore, Nasreddin Hoca, for stereotype themes of older adults. Using the same method, we then analyzed 22,000+ Turkish sayings and proverbs for the same themes. Results indicated older adults to be viewed both positively and negatively. Positive stereotypes included wisdom, warmth, deserving of respect, and retirement. Negative stereotypes included incompetence, inadaptability, and frailty/nearing of death. Older females were viewed more negatively relative to older males. Results indicated views of older adults to parallel those found in contemporary research. Results have implications for the design of interventions to reduce ageism and on the cross-cultural generalizability of age-based stereotypes. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

The relevance of folkloric usage of plant galls as medicines: Finding the scientific rationale.

Science.gov (United States)

Patel, Seema; Rauf, Abdur; Khan, Haroon

2018-01-01

Galls, the abnormal growths in plants, induced by virus, bacteria, fungi, nematodes, arthropods, or even other plants, are akin to cancers in fauna. The galls which occur in a myriad of forms are phytochemically-distinct from the normal plant tissues, for these are the sites of tug-of-war, just like the granuloma in animals. To counter the stressors, in the form of the effector proteins of the invaders, the host plants elaborate a large repertoire of metabolites, which they normally will not produce. Perturbation of the jasmonic acid pathway, and the overexpression of auxin, and cytokinin, promote the tissue proliferation and the resultant galls. Though the plant family characteristics and the attackers determine the gall biochemistry, most of the galls are rich in bioactive phytochemicals such as phenolic acids, anthocyanins, purpurogallin, flavonoids, tannins, steroids, triterpenes, alkaloids, lipophilic components (tanshinone) etc. Throughout the long trajectory of evolution, humans have learned to use the galls as therapeutics, much like other plant parts. In diverse cultures, the evidence of folkloric usage of galls abound. Among others, galls from the plant genus like Rhus, Pistacia, Quercus, Terminalia etc. are popular as ethnomedicine. This review mines the literature on galling agents, and the medicinal relevance of galls. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Russian Folk Culture in the 20 th Century: Oral Evidence of the Villagers (On the Materials of Folklore Expeditions

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Ekaterina A. Dorokhova

2017-12-01

Full Text Available Folk culture is capable of developing certain adaptation mechanisms that help it promptly react to the changing conditions of natural, socio-political, and economic environment. This is evidenced by the stories of the villagers recorded during folklore expeditions to different regions of Russia. The article highlights changes that took place in the traditional Russian culture under the influence of collectivization in the 1920s–1930s, the collapse of kolkhozes in the 1990s, the development of the rural club amateur performances in the Soviet time, the events of the World War II, modern military conflicts, and Chernobyl ecological catastrophe. The authors come to conclusion that representatives of traditional culture flexibly adapt to their new living conditions, while extreme conditions such as wars and ecological catastrophes often contribute to the actualization of folk culture and enable the return of its certain aspects to living practice.

The friends that game together: A folkloric expansion of textual poaching to genre farming for socialization in tabletop role-playing games

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Michael Robert Underwood

2009-03-01

Full Text Available Tabletop role-playing games (RPGs are a folkloric form for creating and reaffirming community bonds and performing identity. Gaming is used to communicate and perform cultural capital and identity through fictional narratives, functioning as a form of community building and/or personal expression. With quotations from ethnographic research over the course of 2 years, including interviews with several groups of gamers and participant observation, I examine the ways that players create and affirm social bonds. I return to Michel De Certeau's idea of textual poaching, as adapted by Henry Jenkins, to contrast with it a new concept of genre farming. As both platform for and object of genre farming, RPGs allow players to display cultural competence, create and reaffirm social ties, and seek entertainment in a collaborative fashion.

Recent Periodicals: Local History, Family and Community History, Cultural Heritage, Folk Studies, Anthropology - A Review (2016

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R. Vladova

2017-12-01

Full Text Available An annual bibliography of papers in the field of local history, family and community history, cultural heritage, folk studies and anthropology, published in 2016, is collected. The inspected journals are: Bulgarian Journal of Science and Education Policy, Chemistry: Bulgarian Journal of Science Education, Current Anthropology, Family and Community History, Folklore, History and Memory, Journal of Family History, Journal of Folklore Research, Past & Present, Winterthur Portfolio. Many of those journals are available at us under subscription.

“Tá cuid de na mná blasta/Some Women Are Sweet Talkers”: Representations of Women in Seán Ó hEochaidh’s Field Diaries for the Irish Folklore Commission

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Lillis Ó Laoire

2017-10-01

Full Text Available This article discusses representations of women in diaries written by  Seán Ó hEochaidh as part of his work as a field collector for the Irish Folklore Commission (1935-1971. Focusing on a number of well-described events and characters, the article reveals the collector’s attitude to women as they emerge from his writing. It also shows how women could help or hinder his collecting work. The disparities of the lives of a number of working women from Donegal during the period are also highlighted.

If only Derrida missed that flight... About the assessment of the "academic achievements" of the so-called "American Anthropology" by Belgrade Structural-semiotic School of Folklore

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Miloš Milenković

2016-02-01

Full Text Available Taking into account recent critiques of "underdevelopment", "positivism", "methodological backwardness" and other failings attributed to socalled "American Anthropology" by some of the authors from the Belgrade Structural-semiotic School of Anthropology of Folklore, I analyse the context in which colleagues and students may be tempted to explain common sense political connection between polyphone ethnography, neo-romanticism and nationalism as counter-intuitive history of the discipline. I already pointed that the important transformative differences in the attitudes towards structuralism between European anthropologists, especially Belgrade Structural-semiotic School of Anthropology of Folklore and so called "American Anthropology", are the consequence of a pure coincidence – the fact that French structuralism and French poststructuralism were launched simultaneously at the American interdisciplinary intellectual scene ("Theory" at the same conference. This ironic concurrence would not be much more than one entertaining episode for students, historians of anthropology and historians of ideas, if there were no attempts (more and more frequent and increasingly fluently articulated to compare different intellectual traditions as they were elements of the same unilineal evolution of the discipline. Belgrade Structural-semiotic School (further called only SS and especially its spiritus movens and most prominent representative Prof. Kovačević started in recent years to criticise some "American Anthropology" measuring its academic "achievement" (the author’s term in comparative perspective and taking as an analytical unit uncritically generalized traditions marked with a single term of "postmodern anthropology" on the one hand, and "anthropology" on the other. Belgrade SS School did develop globally original, although badly promoted and never fully used, battery for the synchronic analysis of the folklore phenomena, but this was done only after

Transylvanianism, Nationalism, Folklore: The Academic Career of Olga Nagy in the Light of her Posthumous Book, Vallomások (2010

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Kata Zsófia Vincze

2016-01-01

Full Text Available The volume Vallomások [‘Testimony’], published posthumously in 2010, is the folklorist Olga Nagy’s (1921-2006 last book. In this paper I will analyze Nagy’s academic significance in the light of her own last self reflection presented in Vallomások. This volume provides an exciting overview of the internal dynamics of East-Central European culture and interethnic relations. While I examine Nagy’s life work, especially her academic work on rural women and her new ideas regarding the alive folklore, I will also reflect on the ideology of so called Transylvanianism that constitutes the framework of many Hungarian writings from Romania. Transylvanianism is a complex ideology rooted in the Hungarian national movement of the nineteenth century, one that later turned into a complex manifestation of the Hungarian minorities in Romania through literature, culture, politics and self-definition. Elaborated by writers, historians and journalists, Transylvanianism after 1918—and even more vehemently after 1947—aimed to preserve and reinforce Hungarian national pride and identity in the region through cultural activities, education and political action.

Revitalising and Innovating Tradition: The Individual Motivations behind New Songs in the Slovácko Region

Czech Academy of Sciences Publication Activity Database

Uhlíková, Lucie

2017-01-01

Roč. 65, č. 2 (2017), s. 289-303 ISSN 0350-0861 Institutional support: RVO:68378076 Keywords : Folklore and creativity * song composing * inovation and revitalization of tradition * cultural heritage * folklore movement * folk revival movement Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Folklore studies

Who's Afraid of the Big, Bad Folk?

Czech Academy of Sciences Publication Activity Database

Feinberg, Joseph Grim

2013-01-01

Roč. 61, č. 5 (2013), s. 548-560 ISSN 1335-1303 Institutional support: RVO:67985955 Keywords : tradition * folklore * folklore studies * reconceptualization * authenticity * the politics of folklore Subject RIV: AJ - Letters, Mass-media, Audiovision http://www.uet.sav.sk/files/etno5-2013-text-web.pdf

The Food Code in the Yakut Culture: Semantics and Functions

Science.gov (United States)

Gabysheva, Luiza Lvovna

2016-01-01

The relevance of researching the issue of a specific cultural meaning for a word in a folklore text is based on its being insufficiently studied and due to the importance for solving the problem of the folklore language semantic features. Yakut nominations for dairy products, which are the key words in the language of the Sakha people's folklore,…

Katalog démonologických pověstí, žánr a strukturální naratologie: literárněteoretické poznámky k folkloristickému dílu

Czech Academy of Sciences Publication Activity Database

Šidák, Pavel

2016-01-01

Roč. 64, č. 3 (2016), s. 408-418 ISSN 0009-0468 Institutional support: RVO:68378068 Keywords : folklore studies * literary studies * methodology * catalogue of folklore material Subject RIV: AJ - Letters, Mass-media, Audiovision

Folklore tourism: a case study Chodsko

OpenAIRE

Opička, Radek

2013-01-01

The objective of bacalary work is to demarcate a Chodsko region for using in tourism sphere with the conservation of etnographic aspect of region. It is there dealing with a question of tourist profile, tourist behaviour and his influence to local environment. A socio- cultural environment is threated through negative tourism phenomenons and processes. Positive tourism phenomenons and processes reinforce a socio-cultural environment and help to keep a local traditions. The top of influence of...

Influence of communal and private folklore on bringing meaning to the experience of persistent pain.

Science.gov (United States)

Hendricks, Joyce Marie

2015-11-01

To provide an overview of the relevance and strengths of using the literary folkloristic methodology to explore the ways in which people with persistent pain relate to and make sense of their experiences through narrative accounts. Storytelling is a conversation with a purpose. The reciprocal bond between researcher and storyteller enables the examination of the meaning of experiences. Life narratives, in the context of wider traditional and communal folklore, can be analysed to discover how people make sense of their circumstances. This paper draws from the experience of the author, who has previously used this narrative approach. It is a reflection of how the approach may be used to understand those experiencing persistent pain without a consensual diagnosis. Using an integrative method, peer-reviewed research and discussion papers published between January 1990 and December 2014 and listed in the CINAHL, Science Direct, PsycINFO and Google Scholar databases were reviewed. In addition, texts that addressed research methodologies such as literary folkloristic methodology and Marxist literary theory were used. The unique role that nurses play in managing pain is couched in the historical and cultural context of nursing. Literary folkloristic methodology offers an opportunity to gain a better understanding and appreciation of how the experience of pain is constructed and to connect with sufferers. Literary folkloristic methodology reveals that those with persistent pain are often rendered powerless to live their lives. Increasing awareness of how this experience is constructed and maintained also allows an understanding of societal influences on nursing practice. Nurse researchers try to understand experiences in light of specific situations. Literary folkloristic methodology can enable them to understand the inter-relationship between people in persistent pain and how they construct their experiences.

Folclore e medicina popular na Amazônia Folklore and popular medicine in the Amazon

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Márcio Couto Henrique

2009-12-01

Full Text Available Discute as relações entre folclore e medicina popular na Amazônia, tendo como referencial de análise o conto "Filhos do boto", de Canuto Azevedo. Aponta que os contos folclóricos estão saturados de elementos da realidade cultural e podem ser utilizados como testemunhos históricos que expressam embates entre diferentes tradições. Os registros folclóricos são fruto do diálogo muitas vezes conflituoso entre folcloristas, cientistas sociais, médicos, pajés e seus seguidores, e sua análise deve ser acompanhada de reflexão sobre as condições de sua produção. Neste caso específico, trata-se de refletir, com base no imaginário de sedução e cura em torno do boto, sobre a possibilidade de ampliar o conhecimento sobre a medicina popular praticada na Amazônia, região de forte presença da pajelança cabocla.This discussion of the relations between folklore and popular medicine in the Amazon takes Canuto Azevedo's story "Filhos do boto" (Children of the porpoise as an analytical reference point. Replete with elements of cultural reality, folk tales can serve as historical testimonies expressing clashes between different traditions. Folk records are fruit of what is often a quarrelsome dialogue between folklorists, social scientists, physicians, and pajés and their followers, and their analysis should take into account the conditions under which they were produced. Based on the imaginary attached to the figure of the porpoise - a seductive creature with healing powers - the article explores how we might expand knowledge of popular medicine as practiced in the Amazon, where the shamanistic rite known as pajelança cabocla has a strong presence.

Studies on wound healing activity of some Euphorbia species on ...

African Journals Online (AJOL)

Background: Plants of Euphorbiaceae are used in folkloric medicines in variety of ailments and well known for chemical diversity of their isoprenoid constituents. This study was carried out to explore the preliminary wound healing potential of four Euphorbia species (E. consorbina 1, E. consorbina 2, E. inarticulata, ...

FOLKLORE ELEMENTS IN BEDRİ RAHMİ EYUBOGLU’S POEMS BEDRİ RAHMİ EYÜBOĞLU’NUN ŞİİRLERİNDE HALK BİLİMİ UNSURLARI

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Bahar DOĞAN

2012-01-01

Full Text Available The aim of this study is to figure out the folklore elements in Eyuboglu’s poems. Thus, his poem books Dol Karabakır Dol and Karadut were examined. In this study, research model was used. In interpreting the results of the study 25 items which were classified by Ornek in his book “Turk Halk Bilimi”, were used.The examples in Eyuboglu’s poems includes village,town and city life; folk architecture; vecihles and transportation technics; ecomomic type; classic folk-economy; nutrition, cuisine, storeroom; measurement, weighing and calculating methods; folk arts and handmade craft; folklore; folk believes, customs and traditions; transition period; stereotyped behaves and expression; folk literature; folk dance; folk music and folk musical instruments.The poet in his pems give place to folk songs and folk arts enormously. The poets who says “ Whenever I hear a village song , I feel shame of my poesy’’ aslo give places to beauty of his country. Occasionally usuing local accents in his poems makes him a simple one from the public.According to this study giving place Eyuboglu’s poems in the textbooks can be an important step for growing up persons who have versatile personality. Bu araştırma Bedri Rahmi Eyüboğlu’nun şiirlerindeki halk bilimi unsurlarını belirlemek amacıyla yapılmıştır. Bu doğrultuda Eyüboğlu’nun Dol Karabakır Dol ve Karadut şiir kitapları incelenmiştir. Araştırmada tarama modeli kullanılmıştır. Elde edilen bulguların yorumlanmasında Örnek’in, Türk Halk Bilimi kitabında halk biliminin çalışma konularını sınıflandırdığı yirmi beş madde kullanılmıştır.Eyüboğlu’nun şiirlerinde köy, kasaba ve kent yaşamı; halk mimarisi; taşıtlar ve taşıma teknikleri; ekonomi türleri; halk ekonomisi; beslenme, mutfak, kiler; ölçme, tartma, hesaplama biçimleri; halk sanatları ve zanaatları; halk bilgisi; halk inançları, töreler, adetler, gelenek ve görenekler; geçiş d

O papel do folclore na motivação para atividades físicas de idosas The role of folklore in the motivation for physical activity of elderly

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Berta Leni Costa Cardoso

2011-03-01

Full Text Available Existem muitos relatos sobre os benefícios biológicos da atividade física em idosos. Porém, o número de praticantes ainda não é satisfatório. Esse ponto controverso foi usado no presente artigo. Pesquisou-se sobre o uso do folclore local como um mecanismo educacional e motivacional útil no aumento da prática de atividades físicas para idosas. Foram entrevistadas idosas do Clube da Amizade em Caetité - BA, que foram motivadas e estimuladas pela dança. Este artigo também usou as reflexões de Paulo Freire, que admite o uso da cultura e contexto de vida pessoal como o mais importante meio de motivação e de educação. Os resultados provaram que é positivo o uso deste citado processo motivacional em estimular idosas nas suas aulas de educação física. Elas relataram que se sentem muito motivadas durante as aulas de dança enquanto podem escutar músicas que as fazem lembrar de seu passado, cultura e valores morais.There are many reports about the biological benefits of the physical activity in older individuals. However the number of physically active elderly is still not satisfactory. This controversial point was used in the present article. It searches if the use of the local folklore as an educating and motivating mechanism was useful for increasing physical activity practices in older individuals. Individuals from "Clube da Amizade" in Caetité city, Bahia (Brazil were interviewed to assess how folkloric dance was used to motivate them in physical education classes. This article also uses the Paulo Freire reflections that admit the use of regional cultural aspects and the life context as the most import strategy to teach and motivate the participants. The results indicated that is positive to use this referred motivational process to stimulate old ladies in the physical education classes. The interviewed ladies reported that they feel very stimulate during dance classes while they listen to music that makes them to remember

Language and folklore in Hamid Mosaddeq’s poem

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IRAN

2016-02-01

Full Text Available Abstract"Standard language", "sub-standard language" and "meta-standard language" are the language types of many varieties. Use of sub- standard language in making poetry, known as “stylistic deviation”, is one of the ways of highlighting poetic language. More attention to this technique of language in the contemporary period was paid by Nima. Nima believed that all words have the potentiality to enter the realm of poetry. No word is essentially poetic or non-poetic, but the way of using words by the poet determines its poetic value.Hamid Mossadegh by the use of sub-standard language elements, in addition to increasing the richness of his poems, made them closer to the mind, language and life of people. Folkloric elements of Mosaddeq’s poems were divided into seven groups: 1 Slang words, 2 common and spoken vocabulary 3 Irony and Proverbs 4 Tlfzhay popular 5 allusion to folk tales 6 folk beliefs and customs 7 local vocabulary.Slang words in poems Mosaddeq in the "verb" and "noun" have been examined. Many folk verbs such as "Shangidan" and "gap zadan (to chat" in Mosaddeq’s poems have been applied. Some of folk verbs in his poems are in such a way that at first, one could not understand the point. These verbs have several meanings that one or more specific meanings are slang, like verb "gereftan (to get" that means "to grow the root of the plant" has slang sense.There is an abundance application of folk nouns in Mosaddeq’s poem. Some of the nouns used in Mosaddeq’s poem, considering their figurative meanings, can be investigated in the folk nouns group, like "foot" in the figurative sense of "will"."Colloquial and current words are of the most frequent elements of folk words in the poetry of Mosaddeq. These words in the category of "nouns" and "verbs" could be analyzed. Lexical verbs such as "to hip" and "Perfume of Moskow" are of this kind. "Irony and Proverbs" are the other folk elements of the poetry of Mosaddeq. "till eye can see

Frank Wollman v kontextu strukturální teorie a terénních výzkumů slovesného folkloru (Příspěvek k nálezu tzv. wollmanovského moravského sběru)

Czech Academy of Sciences Publication Activity Database

Zelenková, Anna

2017-01-01

Roč. 104, č. 4 (2017), s. 493-509 ISSN 0009-0794 Institutional support: RVO:68378017 Keywords : Wollman, Frank * Czech and Slovak folklore studies * the structural theory of folklore * Moravian collection of folk verbal art Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Literary theory

New Sources for Janáček´s Essay Brezovská píseň and His Notation of Long-Drawn-Out Folksongs

Czech Academy of Sciences Publication Activity Database

Procházková, Jarmila

2018-01-01

Roč. 55, č. 1 (2018), s. 41-55 ISSN 0018-7003 Institutional support: RVO:68378076 Keywords : Leoš Janáček (1854-1928) * folklore studies * Janáček´s literary work * Janáček´s collection of folk music Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Folklore studies

The Anti-Diarrhea Properties Of Zingibier Offcinale | Nwoko ...

African Journals Online (AJOL)

Introduction: The crude extract of the plant Zingiber officinale has a high folkloric reputation for anti-diarrhea activity. This study investigated the scientific basis of this folkloric claim. Materials and Methods: Diarrhea was induced in albino mice and albino wistar rats using Castor-oil. The animals (mice) were offered the ...

The Category of Time in Fairy Tales: Searching for Folk Calendar Time in the Estonian Fairy Tale Corpus

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Mairi Kaasik

2011-03-01

Full Text Available The article examines how folk calendar holidays are represented in Estonian fairy tales. It introduces some views presented in folklore studies about the concept of time in fairy tales and finds parallels with them in the Estonian context. The analysis relies on the digital corpus of Estonian fairy tales (5400 variants, created from the texts found in the Estonian Folklore Archives by the Fairy Tale Project of the Department of Estonian and Comparative Folklore, University of Tartu. Folk calendar holidays occur in Estonian fairy tales relatively seldom; most often these are holidays that occupy a significant place in the Estonian folk calendar (Christmas, St. John’s Day, Easter, St. George’s Day. Calendar holidays are notably mentioned more often in tale types which remain on the borderline between the fairy tale and the legend or the fairy tale and the religious tale. In Estonian fairy tales, calendar holidays are used on three levels of meaning: (1 the holiday is organically associated with the tale type; it has an essential role in the plot of the tale; (2 to a certain extent, the holiday could be replaced by another holiday having an analogous meaning; (3 the holiday forms an unimportant or occasional addition to the tale.

A comparison of the chemical constituents of Barbadian medicinal plants within their respective plant families with established drug compounds and phytochemicals used to treat communicable and non-communicable diseases.

Science.gov (United States)

Cohall, D; Carrington, S

2012-01-01

Barbados has a strong base in the practice of folklore botanical medicines. Consistent with the rest of the Caribbean region, the practice is criticized due to lack of evidence on the efficacy and safety testing. The objectives of this review article are i) to categorize and identify plants by their possible indications and their scientific classification and ii) to determine if the chemical constituents of the plants will be able to provide some insight into their possible uses in folklore medicine based on existing scientific research on their chemical constituents and also by their classification. A review of the folklore botanical medicines of Barbados was done. Plants were primarily grouped based on their use to treat particular communicable and non-communicable diseases. Plants were then secondarily grouped based on their families. The chemical profiles of the plants were then compared to established drug compounds currently approved for the conventional treatment of illnesses and also to established phytochemicals. The extensive literature review identified phytochemical compounds in particular plants used in Barbadian folklore medicine. Sixty-six per cent of reputed medicinal plants contain pharmacologically active phytochemicals; fifty-one per cent of these medicinal plants contain phytochemicals with activities consistent with their reported use. Folklore botanical medicine is well grounded on investigation of the scientific rationale. The research showed that fifty-one per cent of the identified medicinal plants have chemical compounds which have been identified to be responsible for its associated medicinal activity. To a lesser extent, approved drug compounds from drug regulatory bodies with similar chemical structure to the bioactive compounds in the plants proved to validate the use of some of these plants to treat illnesses.

Game Edukasi Pengenalan Cerita Rakyat Lampung Pada Platform Android

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Ardi Zulkarnais

2018-01-01

Full Text Available Folklore is an oral tradition story passed down from generation to generation in the life of society. But today, folklore is less popular than abroad cinema which is packed with interesting form. In the Lampung region there is many people who do not know the folklore story about Lampung. In fact, folklore has a moral value, and also as a cultural heritage of the region. The purpose of this research is to design and build an educational game application of Lampung folklore to increase the interest of children and society to know and read Lampung folklore which is a cultural heritage that must be preserved. The development of educational folklore game application constructed from web and mobile platforms. The testing method that is done on aspects of Usability, Functionality, Portability, and Efficiency. Based on the results of usability testing on 5th and 6th grade elementary students using a questionnaire obtained 92.44% results, the functionality tested by 2 experts in the field of software engineering obtained 100% results, portability performed on the smartphone android version of gingerbread until marshmallow obtained 80% , and testing efficiency using Testdroid gets 15% average CPU usage results and an average memory of 175 MB.

GURU MENDONGENG KEARIFAN LOKAL BANYUMASAN

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Sugeng Priyadi

2015-09-01

Full Text Available Teachers skills in the collection and writing of folklore needs to be improved so that the cultural heritage of ancestors can be preserved. Furthermore, teachers develop learning model with storytelling folklore virtue that can be absorbed by the students. Learning model mythlogos- ethos could explain the mandate contained in folklore. The mandate is a form of local wisdom through character education. Keywords: folktale, local wisdom

Elementary Lessons from Indiana's Underground Railroad Institute (July 22-27, 2001).

Science.gov (United States)

Indiana Univ.-Purdue Univ., Indianapolis. Geography Educators' Network of Indiana.

The Geography Educators' Network of Indiana's 2001 Exploring and Teaching Institute led 23 educators from around the state on a six day traveling adventure. Participants explored art, literature/folklore, historical sites and archives, physical environments, architecture, economics, politics, and cultures associated with the Underground Railroad…

Secondary Lessons from Indiana's Underground Railroad Institute (July 22-27, 2001).

Science.gov (United States)

Indiana Univ.-Purdue Univ., Indianapolis. Geography Educators' Network of Indiana.

The Geography Educator's Network of Indiana's 2001 Exploring and Teaching Institute series led 23 educators from around the state on a six day traveling adventure. Participants explored art, literature/folklore, historical sites and archives, physical environments, architecture, economics, politics, and cultures associated with the Underground…

Lidový hudebně-taneční projev jako scénický tvar - folklorní soubory v českých zemích v péči jedné instituce

Czech Academy of Sciences Publication Activity Database

Stavělová, Daniela

2015-01-01

Roč. 25, č. 4 (2015), s. 292-306 ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : folk dance * folk music * stage * show * institution * folklore ensemble * folklore stylization Subject RIV: AC - Archeology, Anthropology, Ethnology

Když o víně, tak povinně!

Czech Academy of Sciences Publication Activity Database

Tyllner, Lubomír

2012-01-01

Roč. 23, č. 11 (2012), s. 32 ISSN 1210-7972 Institutional support: RVO:68378076 Keywords : folklore * folklorism * folk music * folk dance * festival of folk music * Competition festival Subject RIV: AC - Archeology, Anthropology, Ethnology

Transformace folklorní látky v umělecké literatuře : případ démonologické pověsti a díla K. V. Raise

Czech Academy of Sciences Publication Activity Database

Šidák, Pavel

2015-01-01

Roč. 62, č. 5 (2015), s. 707-723 ISSN 0009-0468 Institutional support: RVO:68378068 Keywords : folklore * demonological tale * transformation of folklore material * intertextuality * poetics * K. V. Rais Subject RIV: AJ - Letters, Mass-media, Audiovision

Pastourelle et folklore

OpenAIRE

Dumas, René

2014-01-01

Dans l'état où il nous est parvenu, le Tristan de Béroul ne nous offre que peu d'évocations de la ville et de la demeure où évoluent les différents personnages. Pourtant, bon nombre des moments-clés du roman se situent précisément en milieu urbain : la scène de la marche au suplice d'Iseut, par exemple, ou celle de la fête qui célèbre son retour auprès du roi Marc. Aussi tenterons-nous de préciser dans quel cadre de vie se situent les aventures de Tristan et Iseut et de rechercher l'ordre urb...

Folklorismus v historických souvislostech let 1945-1989 (na příkladu folklorního hnutí v České rapublice)

Czech Academy of Sciences Publication Activity Database

Pavlicová, M.; Uhlíková, Lucie

2008-01-01

Roč. 18, č. 4 (2008), s. 187-197 ISSN 0862-8351 Institutional research plan: CEZ:AV0Z90580513 Keywords : Folklorism * Folklore Movement * Real Socialism * New Songs * Ideology * Censorship * Self-censorship * Personal Motivation Subject RIV: AC - Archeology, Anthropology, Ethnology

Language and folklore in Hamid Mosaddeq’s poem

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نداسادات IRAN

2016-01-01

Full Text Available Abstract"Standard language", "sub-standard language" and "meta-standard language" are the language types of many varieties. Use of sub- standard language in making poetry, known as “stylistic deviation”, is one of the ways of highlighting poetic language. More attention to this technique of language in the contemporary period was paid by Nima. Nima believed that all words have the potentiality to enter the realm of poetry. No word is essentially poetic or non-poetic, but the way of using words by the poet determines its poetic value.Hamid Mossadegh by the use of sub-standard language elements, in addition to increasing the richness of his poems, made them closer to the mind, language and life of people. Folkloric elements of Mosaddeq’s poems were divided into seven groups: 1 Slang words, 2 common and spoken vocabulary 3 Irony and Proverbs 4 Tlfzhay popular 5 allusion to folk tales 6 folk beliefs and customs 7 local vocabulary.Slang words in poems Mosaddeq in the "verb" and "noun" have been examined. Many folk verbs such as "Shangidan" and "gap zadan (to chat" in Mosaddeq’s poems have been applied. Some of folk verbs in his poems are in such a way that at first, one could not understand the point. These verbs have several meanings that one or more specific meanings are slang, like verb "gereftan (to get" that means "to grow the root of the plant" has slang sense.There is an abundance application of folk nouns in Mosaddeq’s poem. Some of the nouns used in Mosaddeq’s poem, considering their figurative meanings, can be investigated in the folk nouns group, like "foot" in the figurative sense of "will"."Colloquial and current words are of the most frequent elements of folk words in the poetry of Mosaddeq. These words in the category of "nouns" and "verbs" could be analyzed. Lexical verbs such as "to hip" and "Perfume of Moskow" are of this kind. "Irony and Proverbs" are the other folk elements of the poetry of Mosaddeq

Naming Disney's Dwarfs.

Science.gov (United States)

Sidwell, Robert T.

1980-01-01

Discusses Disney's version of the folkloric dwarfs in his production of "Snow White" and weighs the Disney rendition of the dwarf figure against the corpus of traits and behaviors pertaining to dwarfs in traditional folklore. Concludes that Disney's dwarfs are "anthropologically true." (HOD)

CERITA RAKYAT BERBASIS MOBILE UNTUK ANAK SEKOLAH DASAR

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I Nyoman Laba Jayanta

2017-11-01

Full Text Available This research aimed at developing a mobile-based folklore with local wisdom inserted for elementary school students in which the language used is Balinese. The present research was applying System Development Life Cycle (SDLC research method. The study underwent five steps, that is, Analysis, Design, Implementation, Testing, and Evaluation. The first step of this research was need analysis of the application. In this step, the need analysis of content application and application development was done. The next step was application design including flowchart design and storyboard. The steps of development was using application design plan. In this step, the result was Balinese folklore application with local wisdom inserted. To test the function of this application, an application test was done by applying black box method. This evaluation was conducted by involving teacher and elementary school students at SDN 3 Banyuning. The result of evaluation showed that it was found 20 out of 25 students liked this folklore application with local wisdom inserted.

Online úskalia folkloristického výskumu

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Eva Šipöczová

2012-12-01

Full Text Available The problematic aspects of internet research are slowly becoming manifest in all the Humanities. The primary concern of ethnology and folkloristics is contemporary folklore – anecdotes, urban legends, rumours, conspiracy theories, all of which are abundant on the internet. Neverteless, the nature of virtual reality has given rise to new methodological problems and uncertainties. How should we collect folklore material on the internet? A conflict rages between classic face-to-face research, and the physically distanced research of the vitrual space. Virtual space has diffrent rules and principles of communication; it functions in a diffrent way. Who is our informer? who is the proprietor of folklore on the internet? And how can we give relevant context to collected materials? The next ambuscade is the fact that the internet creates a inexhaustible quantity of folklore material which lives in databases, discussion forums, emails, chatrooms, social networks, etc.--How can we use this huge database? This contribution does not profess to provide a correct methodology for conducting qualitative folklore research on the internet. Its purpose is to point out the problems and thus join the discussion already taking place around the world, and increasingly in our region.

PEMANFAATAN CERITA RAKYAT SEBAGAI PENANAMAN ETIKA UNTUK MEMBENTUK PENDIDIKAN KARAKTER BANGSA

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M. Kristanto

2014-08-01

Full Text Available Folklore that are emerging in various regions in Indonesia have ethical moral values that are beneficial to the formation of a golden generation of Indonesia. Folklore when inherited or inculcated into children early on will equip students motor and psychomotor development, especially in students' character membangan early winning personality. Planting of ethics is intended to form a person's character that leads to positive things. Planting good ethics can certainly build character, attitudes, and behaviors that reinforce soft skills to instill good habits. Utilization of folklore that there are very effective to teach ethics and good morals. Through the characters in the story can be conveyed attitudes, behaviors, and said words that reflect the character and moral ethics. In the story reflected the presence of noble values, among others, honesty, cooperation, hard work, responsibility, religion. These values can be used as a means of character education. Keywords: folklore, values, ethics, character education.

Zítra se bude tančit všude, aneb jak jsme se protancovali ke svobodě. Dichotomie tzv. folklorního hnutí druhé poloviny 20. století

Czech Academy of Sciences Publication Activity Database

Stavělová, Daniela

2017-01-01

Roč. 104, č. 4 (2017), s. 411-432 ISSN 0009-0794 R&D Projects: GA ČR(CZ) GA17-26672S Institutional support: RVO:68378076 Keywords : folklore revival movement * folklorism * folk ensembles * oral history * narratives * Czech Republic Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Antropology, ethnology

Folklore Studies on Birth Related Customs within the Banat Community

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Alexin Otilia Daniela

2017-12-01

Full Text Available Birth is perceived as a threshold, a milestone, and is best described as passing from one stage to another and from one status to another. This article aims to present the customs regarding the birth of a child, as they were preserved in the Banat folk mentality: the origin of the midwife and her role as mediator, the belief in the unfailing destiny foreseen by the book of fate, the rite of the first bath having a huge importance for the future of the child and a series of magic and religious acts meant to ward off the Evil forces that intend to harm the child and to restore the balance.

The Manager's Job: Folklore and Fact

Science.gov (United States)

Mintzberg, Henry

1975-01-01

Contrasts popular myths about managers' duties with the facts, as indicated by various studies of managers and how they function. The author argues that managers often have distorted views of their role, and that they must first recognize what their job really involves in order to perform it effectively. (JG)

[Do regional and generational differences in attitudes toward "Luck Resource Belief" exist?].

Science.gov (United States)

Murakami, Koshi

2016-04-01

This article examines whether belief in superstitions and folklore differs by age and degree of modernization specifically. This study investigated regional and generational differences in attitudes toward "Luck Resource Belief," a notion regarding luck. The 500 Japanese participants in our sample were stratified by place of residence, age, and income. The results reflected gender differences, but not regional or generational differences with regard to the "Luck Resource Belief" scale scores. Based on these results, the hypothesis that the mass media plays a major role in the dissemination of information about superstitions and folklore is discussed in this context.

Literatura Oral Hispanica (Hispanic Oral Literature).

Science.gov (United States)

McAlpine, Dave

As part of a class in Hispanic Oral Literature, students collected pieces of folklore from various Hispanic residents in the region known as "Siouxland" in Iowa. Consisting of some of the folklore recorded from the residents, this paper includes 18 "cuentos y leyendas" (tales and legends), 48 "refranes" (proverbs), 17…

Exploring a Common Past: Researching and Interpreting the Underground Railroad.

Science.gov (United States)

National Park Service (Dept. of Interior), Washington, DC.

Although the Underground Railroad has been an integral part of U.S. history and folklore for well over 150 years, the recent past has seen an increased public interest in the identification of historic sites associated with the experiences of fugitive slaves. This booklet is part of a National Park Service initiative to design research methods…

Methodological issues of genetic association studies.

Science.gov (United States)

Simundic, Ana-Maria

2010-12-01

Genetic association studies explore the association between genetic polymorphisms and a certain trait, disease or predisposition to disease. It has long been acknowledged that many genetic association studies fail to replicate their initial positive findings. This raises concern about the methodological quality of these reports. Case-control genetic association studies often suffer from various methodological flaws in study design and data analysis, and are often reported poorly. Flawed methodology and poor reporting leads to distorted results and incorrect conclusions. Many journals have adopted guidelines for reporting genetic association studies. In this review, some major methodological determinants of genetic association studies will be discussed.

Against Her Kind: The Phenomenom of Women against Women in Ovia Cult Worship

Science.gov (United States)

Yakubu, Anthonia Makwemoisa

2014-01-01

This paper addresses the incidence of 'Women against Women' in Nigerian folklore. Much has been written on Nigerian folklore, but mainly from within the mortal axis, as reflected in many folktales that cut across different communities in Nigeria. However, it has been observed that this gender phenomenon extends to the supernatural realm, where…

Between Folk and Lore: Performing, Textualising and (misInterpreting the Irish Oral Tradition

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Vito Carrassi

2017-10-01

Full Text Available Folklore, as a historical and cultural process producing and transmitting beliefs, stories, customs, and practices, has always thrived and evolved in the broader context of history and culture. Consequently, tradition and modernity have long coexisted and influenced one another, in particular in the world of folk narratives, orality and literature, storytellers and writers. Since the nineteenth century, folklorists (a category including a variety of figures have collected, transcribed and published pieces of oral tradition, thus giving folklore a textual form and nature. However, folk narratives continue to be also a living and performed experience for the tradition bearers, a process giving rise to ever new and different expressions, according to the changing historical, social, cultural, and economic conditions. To be sure, folklore – and folk narrative – needs to be constantly lived and performed to remain something actually pertinent and significant, and not only within the oral and traditional contexts. Interestingly, between the nineteenth and the twentieth centuries, folklore increasingly came to be regarded as and transformed into an inheritance, a valuable, national heritage particularly fitting for those countries, such as Ireland, in search of a strong, national identity. In this light, folklore and folk narratives, beside their routine existence within their original contexts, were consciously “performed” by the official culture, which employed them in politics, education, literature, etc. In the process, it could happen that folk materials were dehistoricised and idealised, “embalmed” according to Máirtin Ó Cadhain, and even trivialised. This situation was turned into a fruitful and significant source of inspiration for the literary parody of Myles na gCopaleen (Flann O’Brien who, in his Gaelic novel, An Béal Bocht, revealed the funny yet distressing truth of the Irish folklore being misunderstood and betrayed by

Christianity and Community development in Igboland, 1960-2000

African Journals Online (AJOL)

FEN

In the words of Benjamin Botkin, folklore is a body of traditional beliefs, customs, and ... artists weave in their works in order to give it a true touch of beauty and glamour ... Achebe had a profound influence on many other Nigerian novelists ... culture and the folklore of her people which unconsciously shaped the context ...

Star names their lore and meaning

CERN Document Server

Allen, Richard H

1963-01-01

Here is an unusual book for anyone who appreciates the beauty and wonder of the stars. Solidly based upon years of thorough research into astronomical writings and observations of the ancient Chinese, Arabic, Euphrates, Hellenic, and Roman civilizations, it is an informative, non-technical excursion into the vast heritage of folklore and history associated with the heavenly bodies. From his studies of the writings of scores of ancient astronomers, the author has come up with a fascinating history of the names various cultures have given the constellations, the literary and folkloristic uses

On the Complexity of Computing Optimal Private Park-and-Ride Plans

DEFF Research Database (Denmark)

Olsen, Martin

2013-01-01

or size of the parties inputs. This is despite the fact that in many cases the size of a party’s input can be confidential. The reason for this omission seems to have been the folklore belief that, as with encryption, it is impossible to carry out non-trivial secure computation while hiding the size...... that the folklore belief may not be fully accurate. In this work, we initiate a theoretical study of input-size hiding secure computation, and focus on the two-party case. We present definitions for this task, and deal with the subtleties that arise in the setting where there is no a priori polynomial bound...

Film Animasi Malaysia: Narasi Verbal ke Visual

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Ahmad Nizam bin Othman

2009-03-01

Full Text Available Among the issues are to look into the approaches and education problems that happen in the verbal narration in old society and how the construction and preservation of legends and folklore into animation forms. This paper is to identify the icon, structure and method that use in film animation to emphasize the culture understanding of the legends and folklore. The ideas of this paper are to identify form; icon and meaning that attach in local folklore and translated into animation based on culture theory. This case study research involves collecting data through documentation; including interview method, observation and visual understanding on animation collection. The data analysis concentrates on technique and overall animation process, focusing on its impact on culture and local society. Legend and folklore are a part of Malays tradition culture that has been spreading and handing on from one generation to another. The story of fairy tales, myths, extraordinary and miraculous of early centuries of human evolution now been represent in new form, that involved visual and other human sense’s. This paper will discuss about the condition of the understanding and imaginations in this new generation are still same as early century about the beauty of Mahsuri, the extraordinary and enthusiastic of Hang Tuah and the kindheartedness of Bawang Putih. How human accepted and preserves tradition and culture customs but in adaptation process, upgrading and decent with civilization maturity. The outcome are expected to contribute in preserving culture and tradition.

Koleda jako folklorní žánr křesťanského Západu a Východu: k biblickým a apokryfním námětům v západoslovanském folkloru

Czech Academy of Sciences Publication Activity Database

Frolcová, Věra

2013-01-01

Roč. 82, 1-2 (2013), 112-124 ISSN 0037-6736 Institutional support: RVO:68378076 Keywords : carol and Christianity * Slavia Romana * ethnomusicology * studies of Slavic folklore Subject RIV: AC - Archeology, Anthropology, Ethnology

Od lidové písně k evropské etnologii - 100 let Etnologického ústavu Akademie věd, Brno 5.-7.10.2005

Czech Academy of Sciences Publication Activity Database

Procházková, Jarmila

2006-01-01

Roč. 43, č. 1 (2006), s. 99-100 ISSN 0018-7003 Institutional research plan: CEZ:AV0Z90580513 Keywords : Moravian folksong * folklore studies * ethnology * Brno Subject RIV: AC - Archeology, Anthropology, Ethnology

[On the "folkloric" psychotherapy to schizophrenic patients--based on phenomenological study].

Science.gov (United States)

Yamada, T; Yamada, Y

1998-01-01

Psychotherapeutic treatment of schizophrenia is generally considered difficult. One reason for this is that the doctor and patient can easily fall into a relationship of conflict with each other concerning the propriety of "judgments which are morbidly and mistakenly made (K. Jaspers)", referred to as delusions. We carried out close phenomenological structure-analyses of the delusions and of patients' fundamental experiences, based on the premise that a patient with delusions probably has some actual grounding for these in the patient's own concepts, considering the fact that the patient firmly believes these delusions. As a result, we have clarified the following matters from the primary experience of delusions. 1) We found that patients are in a conflicted mental condition which can be considered a collapse of adaptability to "Seken". 2) In this condition of conflict, patients feel guilt relative to "Seken" or feel that they are indebted and should be punished. When patients complained of their primary experience, we were able to persuade them to reserve their judgment of their primary experience, by 3) having each patient listen to the folktale "Torikuyou" in which the "logic of stealing" and the "logic of being stolen", appear in a reciprocal relationship relative to the constitution of crime and punishment, by 4) explaining to each patient about the ambiguity and reciprocity of reality experienced, 5) instead of disputing the propriety of patient's judgment about primary experience, doctor and patient worked together to enable the patient to form a positive understanding of the primary experience. 6) We reduced the patient's psychological conflict relative to primary experience, and were able to defuse and distance the patient's delusions caused by erroneous judgment of primary experience. 7) Regarding the area in which this type of psychotherapeutic approach shows efficacy, we analyzed the concept of "Seken" as a world which can cause conflicts relative to primary experiences. 8) We also analyzed "Giri" as a norm of "Seken" from which patients misconceive that they have deviated, in addition, 9) from the viewpoints of anthropology and cultural anthropology, we analyzed the bases for "Kotowaza (proverbs)" and "Monogatari (folktale)" such as "Torikuyou", which themselves can show psychotherapeutic efficacy. We consider that the psychotherapeutic approach has previously been developed around the concepts of the "individual" and "society", but we made our psychotherapeutic approach from the concept of "Seken" (yononaka = hito: person) that is a structure with deep strata of tradition and culture in Japan, and have reported its concrete development through the presentation of 3 typical cases of schizophrenia with difficulty in adapting to society due to showing the delusion of persecution in their foreground.

Quantification of total tannin, flavonoid contents and pharmacognostic study of the seeds of Swietenia mahagoni (Linn.

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Tasmia Rahman

2016-11-01

Full Text Available Objective: To justify the folkloric use of Swietenia mahagoni (S. mahagoni seeds, 90% ethanolic extract and their aqueous and organic partitioning substances were evaluated for their possible antidiarrhoeal and antimicrobial potentials in vivo. Methods: Crude ethanolic extract of S. mahagoni seeds were subjected and partitioned into fractions using solvents at different polarity. Antimicrobial and antidiarrheal activities were evaluated and subsequently outcomes were corresponded with the conventional standard drugs. Results: The antidiarrheal activity was assessed using mouse model, where unfractionated ethanolic extract significantly reduced, the number, onset, rate and weight of diarrheal episodes. This fraction showed the limited number of defecation episodes of 27.0% and 40.9% at dose of 200 mg/kg and 400 mg/kg body weight respectively and reference drug, loperamide, showed 53% at a dose of 50 mg/kg. All extract fractions exhibited the significant potential to kill or subside the growth of known Gram-positive and Gram-negative bacteria. Conclusions: Ethanolic extract and their aqueous and organic fractious revealed the seeds of S. mahagoni (Linn. have the potential to be used as a remedy for diarrhea and known pathogenic microbes which ensured the folkloric use of the seeds of S. mahagoni.

EL MOVIMIENTO INSTITUCIONALIZADO: DANZAS FOLKLÓRICAS ARGENTINAS, LA PROFESIONALIZACIÓN DE SU ENSEÑANZA / Institutionalized movement: professional education of argentine folk dances

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María Belén Hirose

2010-12-01

Full Text Available En 1948 se creó la Escuela Nacional de Danzas Folklóricas, como parte del Plan Quinquenal del primer gobierno de Juan D. Perón (1946-1952. Así se dio inicio a la profesionalización de la transmisión y difusión de las danzas folklóricas en su carácter de danzas nacionales, tarea que quedaría concretada con la formación de un cuerpo de profesores nacionales de danza. Este proceso suponía el establecimiento de criterios de selección y transformación de aquellas danzas que se consideraran adecuadas para dar materialidad, mediante coreografías, música, vestimenta y eventos, al sentimiento de la nacionalidad. El folklore académico, en pleno proceso de consolidación como disciplina científica, fue también funcional al proyecto nacional, proveyendo los criterios para la creación del repertorio de danzas que sería enseñado en Buenos Aires y transportado luego a las provincias.En este artículo nos proponemos describir el desarrollo histórico que posibilitó la institucionalización de la enseñanza de las danzas folklóricas en la Argentina, y los efectos de dicha institucionalización. Exploramos el rol que diversos grupos o individuos pertenecientes al ámbito político, cultural y/o académico, asignaron a la enseñanza de las danzas folklóricas en las diferentes etapas del proceso de construcción y fortalecimiento del estado-nación argentino.Palabras clave: danza; folklore; Argentina; docencia; peronismoAbstractIn 1948 Argentina’s National School of Folkloric Dances was created as a part of Juan D. Peron’s “Quinquennial Plan”, launched during his first administration. Thus, the transmission and diffusion of folkloric dances as national symbols began to be professionalized, the development of which was accomplish by the instruction of a troupe of national dance teachers. This process required a repertoire based on the selection and transformation of those dances considered to be adequate expressions of Argentine

Mezinárodní festival etnologických dokumentárních filmů „Kratovo 2016“

Czech Academy of Sciences Publication Activity Database

Pavlásek, Michal

2017-01-01

Roč. 27, č. 1 (2017), s. 103 ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : International Festival * Ethnological documentaries * Documentary films * Ethnology * Kratovo Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Folklore studies

La revista Demófilo y la antropología cultural en Andalucía

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Rodríguez Becerra, Salvador

2002-06-01

Full Text Available Published since 1987 by the Machado Foundation, of Seville, Demófilo represents the resumption of scientific folklore studies in the late 19^th century championed by Antonio Machado y Álvarez and published in the journal El Folk-lore Andaluz. The basic objectives of Demófilo are «to rescue, analyze and divulge Andalousia's traditional culture.» The journal is oriented toward high schools, colleges and universities in Andalousia as well as any institution interested in the traditional culture of the area, such as museums and organizations supporting Andalousia's cultural heritage. The authors also include in this article a summary of the journal's monographic issues published to date.

Publicación de la Fundación Machado, de Sevilla, y nacida en 1987, Demófilo enlaza con su predecesora en el siglo XIX, El Folk-lore Andaluz, del movimiento sevillano de estudio científico del folklore que animara sobre todo Antonio Machado y Álvarez. Demófilo tiene como objetivos básicos «rescatar, analizar y difundir la cultura tradicional andaluza» y va dirigida especialmente a centros de enseñanza media y universidades de Andalucía, así como a instituciones interesadas en la cultura tradicional de la región, como museos y asociaciones de defensa del patrimonio cultural. Los autores incluyen también en este artículo un resumen de los números monográficos de la revista publicados hasta la fecha.

The role and importance of Tuvan literature and teaching it in schools in the preservation and development of Tuvan language

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Lidiia Kh. Oorzhak

2018-03-01

Full Text Available The authors of the article start off by expressing their concern about the level of command of Tuvan by the younger generation, especially children. Preserving and developing Tuvan language is impossible without literature in Tuvan and teaching it in schools and other educational institutions. The article deals with the issues of teaching Tuvan literature in secondary comprehensive schools of the Republic of Tuva. The authors also provide an overview of textbooks of Tuvan literature compiled at the laboratory of Tuvan philology, Institute for the Development of National Schools of the Republic of Tuva, in compliance with the Federal educational standards of Russian Federation. The textbook provide the mandatory minimum of the standard-provided content of general education and guarantee the required quality of knowledge for school graduates. In 2013-2017, textbooks titled «Tөreen chogaal» (Literature in the Native Tongue were compiled and published for Grades 5-9, as well as two accompanying textbooks for Grades 5 and 6. The textbooks rely on the methodological principles of the study program «Tyva aas chogaaly bolgash literatura. Niiti өөredilge cherleriniң 5-11 klasstarynga chizhek programma» (Tuvan folklore and literature. Sample Study Program for Grade 5-11 of Comprehensive Schools. In comparison to the previous generation of textbooks, these have been largely updated both in their structure and scope of its content. The texts were grouped in the following categories: “Folklore, the nation’s boundless treasury”, “From folklore to literary genres”, “The world of childhood”, “The world of wonders”, “Holy places”, “The Stars of Victory” and “Animal world”. They prominently feature folklore texts, including shaman songs; tests and creative tasks have also been developed. In terms of their content and methodology, the textbooks intend to familiarize students with the spiritual, moral and aesthetic values of

Finnish Kalevala and Estonian Kalevipoeg / Jaan Puhvel

Index Scriptorium Estoniae

Puhvel, Jaan, 1932-

2003-01-01

Tõlgitud kogumikust: The world of the Kalevala : essays in celebration of the 150 year jubilee of the publication of the Finnish national epic / ed. Kai Laitinen. Los Angeles : UCLA Centre for the Study of Folklore & Mythology, 1987

Prediction of disease and phenotype associations from genome-wide association studies.

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Stephanie N Lewis

Full Text Available Genome wide association studies (GWAS have proven useful as a method for identifying genetic variations associated with diseases. In this study, we analyzed GWAS data for 61 diseases and phenotypes to elucidate common associations based on single nucleotide polymorphisms (SNP. The study was an expansion on a previous study on identifying disease associations via data from a single GWAS on seven diseases.Adjustments to the originally reported study included expansion of the SNP dataset using Linkage Disequilibrium (LD and refinement of the four levels of analysis to encompass SNP, SNP block, gene, and pathway level comparisons. A pair-wise comparison between diseases and phenotypes was performed at each level and the Jaccard similarity index was used to measure the degree of association between two diseases/phenotypes. Disease relatedness networks (DRNs were used to visualize our results. We saw predominant relatedness between Multiple Sclerosis, type 1 diabetes, and rheumatoid arthritis for the first three levels of analysis. Expected relatedness was also seen between lipid- and blood-related traits.The predominant associations between Multiple Sclerosis, type 1 diabetes, and rheumatoid arthritis can be validated by clinical studies. The diseases have been proposed to share a systemic inflammation phenotype that can result in progression of additional diseases in patients with one of these three diseases. We also noticed unexpected relationships between metabolic and neurological diseases at the pathway comparison level. The less significant relationships found between diseases require a more detailed literature review to determine validity of the predictions. The results from this study serve as a first step towards a better understanding of seemingly unrelated diseases and phenotypes with similar symptoms or modes of treatment.

Aukštaitijos ir Žemaitijos paribio dainuojamojo folkloro ypatumai

OpenAIRE

Račiūnaitė-Vyčinienė, Daiva

2007-01-01

The article discusses the subject, which has remained almost unstudied by ethnomusicologists, i. e. the peculiarities of the traditional sung folklore of the region of the borderline between the Upper Lithuania and Samogitia. Most attention is dedicated to the “Samogitian” character of the peripheral Upper Lithuania. The article emphasizes that the folklore singing traditions of the peripheral Upper Lithuania (Radviliškis, Šiauliai, Pakruojis and adjacent areas) may be characterized by peculi...

Evaluation of the antimicrobial activity of crude extracts and ...

African Journals Online (AJOL)

The study provides some justifications for the folkloric use of AP seed powder as an antiseptic paste and warrants further studies to determine the structure of the active compound in chromatographic fraction ST 13 -15F. Key words: Adenanthera pavonina, antimicrobial activity, chromatographic fractions, methanolic extract.

Conflictos identitarios del Pueblo Negro en el Valle del Chota-Provincia de Imbabura: entre la folklorización y la descolonización.

OpenAIRE

León Bernardo, Alexandra Natali

2017-01-01

Chota-Imbabura between the folklorization and the decolonization have been the principal motivation to be able to realize this investigation, since it is necessary to recognize colonial processes that the people should identify as such and since inside his context such certain conceptualizations are re-meant as: identity, culture, cultural inheritance, African decent black like point of item the decolonization and the folklorization. In such a way that the black people of the Valley of the Ch...

Cognitive “Boy stories”: urban folklore and urban topographies

Directory of Open Access Journals (Sweden)

Bojan Žikić

2016-02-01

Full Text Available The culturally cognitive perception of Belgrade’s topographies is considered through its deployment, symbolic use and narrative foundation. As the explanatory material-one football-media incident, the use of certain areas of the city in a spectacleceremonial manner, knowledge and lore of certain elements of the Belgrade topographies and the organization of «the football Belgrade»-were considered. The attitude is taken that the topography of a city is a multifaceted cultural constituent, whose structure of particular meaning, as a part of cultural communication, is determined by the very fact it is an urban space. Physical aspects of spatial-ness are reduced to relationism, i.e. it has a meaning for the cultural communication only when the elements of urban topographies are brought into correlation. Other characteristics of physical spatial-ness are irrelevant for such communication. Meaning relations in which elements of urban topographies exist are formed on the very fact of them being urban, that is, the afore mentioned denotation that is ascribed to space, stems from those cultural features and artifacts that are associated in a given milieu with certain concrete elements of urban topographies.

Effect of Cultural Themes on Forming Cotard’s Syndrome: Reporting a Case of Cotard’s Syndrome with Depersonalization and Out of Body Experience Symptoms

OpenAIRE

Ghaffari Nejad, Alireza; Mehdizadeh Zare Anari, Ali; Pouya, Fatemeh

2013-01-01

Objective: Cotard’s syndrome is a rare psychiatric syndrome. Its core symptom is nihilistic ideation or delusion. Case Report: A female patient with Cotard’s syndrome symptoms associated with out of body experience and depersonalization, and complicated grief was referred for evaluation. She believed that she was killed by a creature named "Aal" in the Persian folklore Conclusions: Cultural and superstitious beliefs could affect the forming of the complex constellation of the patient’s sympto...

Ethnocultural Development of Future Music Teachers in Process of the Tatar Piano Music’s Studying

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Liliya I. Salikhova

2017-12-01

Full Text Available Studying the Tatar piano repertoire as element of national musical traditions is an important factor of ethnocultural development of the future music teachers of Tatarstan in the course of vocational training in higher education institution. It is caused inexhaustible by opportunities of ethnomusical heritage in formation of the personality, need of development in students of professionally significant ethnopsychological qualities, readiness for the solution of musical and educational tasks on the basis of the Tatar national culture. Disclosure of potential of the Tatar piano music in ethnocultural development of future music teachers became a research objective. On the basis of synthesis of experience of musical and performing training of future music teachers - students of Leo Tolstoy Institute of Philology and Intercultural Communication of Kazan Federal University, the performing analysis of the Tatar piano music, authors submit compositions in which found the brightest embodiment of tradition of the Tatar folk art. It is shown that, working on piano works, students learn deep moral and esthetic meaning of the Tatar folklore. They develop ethnocultural ideas of love, family values, gratitude to parents and respect of seniors, devotion to traditions of a sort, the importance of family education. Performance of songs always opened the emotional world of the person, reflected his intimate thoughts and experiences connected with hard destiny, aspiration fortunately and belief in the best. The deep moral and esthetic meaning of the Tatar folklore embodied by means of expression of piano music is shown in article; musical contents of works of the Tatar composers, their variety and opportunities in ethnocultural development of future music teachers reveal.

Ilmus folkloristide ja etnoloogide ühisväljaanne / Varje Sootak

Index Scriptorium Estoniae

Sootak, Varje, 1946-

2004-01-01

Rmt.: Papers delivered at the symposium "Sacred and profane in the dialogue of cultures" : [Aprill, 2002, Tartu] / Department of Estonian and Comparative Folklore, Department of Ethnology, University of Tartu ; [editors Art Leete, Ülo Valk]. - (Studies in Folk Culture. Vol. 1). Tartu, 2003

POLTERGEIST PHENOMENA IN CONTEMPORARY FOLKLORE

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Oana VOICHICI

2017-05-01

Full Text Available The article deals with instances of the supernatural in Romanian urban legends, namely what we call the strigoi , or poltergeist. Usually, folklorists tend to exclude the supernatural f rom the category of urban legends, however we have decided to take these accounts into consideration based on the fact that the transmitter, the narrators do not distinguish between these elements and the rest of contemporary legends and today’s popular cu lture abounds in such accounts.

POLTERGEIST PHENOMENA IN CONTEMPORARY FOLKLORE

OpenAIRE

Oana VOICHICI

2017-01-01

The article deals with instances of the supernatural in Romanian urban legends, namely what we call the strigoi , or poltergeist. Usually, folklorists tend to exclude the supernatural f rom the category of urban legends, however we have decided to take these accounts into consideration based on the fact that the transmitter, the narrators do not distinguish between these elements and the rest of contemporary legends and today’s popular cu lture abounds in such accounts.

Discovering Folklore Through Community Resources.

Science.gov (United States)

Sumpter, Magdalena Benavides, Ed.

The folkways and cultural heritage of the Mexican Americans of South Texas are explored in this volume which is designed to provide the student with the opportunity for cultural enrichment, oral language development, and vocabulary expansion. The first chapter deals with "Creencias" which are common beliefs handed down from generation to…

In Search of a National Epic: The use of Old Norse myths in Tolkien's vision of Middle-earth

Directory of Open Access Journals (Sweden)

Tommy Kuusela

2014-05-01

Full Text Available In this article some aspects of Tolkien’s work with regard to his relationship to folklore and nationalism are presented. It is also argued, contrary to Lauri Honko’s view of literary epics, that pre-literary sources constitute a problem for the creators of literary epics and that their elements can direct the choice of plot and form. Tolkien felt that there was a British – but no English – mythology comparable to the Greek, Finnish or Norse ones. He tried to reconstruct the ‘lost mythology’ with building blocks from existing mythologies, and dedicated his work to the English people. In this, he saw himself as a compiler of old source material. This article considers his use of Old Norse sources. With Honko’s notion of the second life of folklore it is argued that Tolkien managed to popularise folklore material while his efforts to make his work exclusively English failed; for a contemporary audience it is rather cross-cultural.

In Vivo Hypoglycemic Effect of Kigelia africana (Lam): Studies With Alloxan-Induced Diabetic Mice.

Science.gov (United States)

Njogu, Stephen M; Arika, Wycliffe M; Machocho, Alex K; Ngeranwa, Joseph J N; Njagi, Eliud N M

2018-01-01

The claims by the traditional herbal medicine practitioners that Kigelia africana has bioactivity against several diseases, including diabetes mellitus, were investigated in this study. Type I diabetes mellitus was induced in mice by intraperitoneal administration of alloxan monohydrate followed by treatment with the therapeutic doses of the aqueous and ethyl acetate leaf extract of K africana to the experimentally diabetic mice. The treatment effects were compared with the normal control, diabetic control, and diabetic control rats treated with a standard antidiabetic drugs (insulin administered intraperitoneally at 1 IU/kg body weight in 0.1 mL physiological saline or glibenclamide administered orally at 3 mg/kg body weight in 0.1 mL physiological saline). Phytochemical composition of the leaf extract was assessed using standard procedures and mineral elements assessed using atomic absorption spectrophotometry and total reflection X-ray fluorescence system. Oral and intraperitoneal administration of the aqueous and ethyl acetate leaf extract caused a statistically significant dose-independent reduction in plasma glucose level in alloxan-induced diabetic mice. The observed hypoglycemic activity of this plant extract could be attributed to the observed phytochemicals and trace elements, which have been associated with exhibiting antidiabetic properties. Therefore, the data appear to support the hypoglycemic effects of K africana validating its folkloric usage.

From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research.

Science.gov (United States)

Zhang, Y-P; Zhang, Y-Y; Duan, D D

2016-01-01

Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the wide individual variations in fat distribution, degree of fatness or health risks, and genetic variants identified in the genome-wide association studies (GWAS). In this review, we will address this important issue with the introduction of phenome, phenomics, and phenome-wide association study (PheWAS). We will discuss the new paradigm shift from GWAS to PheWAS in obesity research. In the era of precision medicine, phenomics and PheWAS provide the required approaches to better definition and classification of obesity according to the association of obese phenome with their unique molecular makeup, lifestyle, and environmental impact. Copyright © 2016 Elsevier Inc. All rights reserved.

African American Physical Education Folklore Surrounding School Transition

Science.gov (United States)

Woodruff, Elizabeth A.; Curtner-Smith, Matthew D.

2015-01-01

Transferring from elementary to secondary school can be difficult for many children, and students making this transition often suffer from anxiety and stress. One source of stress can be found in the scary stories transitioning pupils hear about their new schools, particularly those about physical education and sport. The purpose of this study was…

Dangers of the vagina.

Science.gov (United States)

Beit-Hallahmi, B

1985-12-01

Beliefs, myths, and literary expressions of men's fear of female genitals are reviewed. Both clinical evidence and folklore provide evidence that men imagine female genitals not only as a source of pleasure and attraction, but also as a source of danger in a very physical sense. The vagina dentata myth has many versions, including some modern ones, and its message is always the same: an awesome danger emanating from a woman's body. The prevalence of such feelings in folklore and in literature is noted.

Genome-wide association study of multiplex schizophrenia pedigrees

DEFF Research Database (Denmark)

Levinson, Douglas F; Shi, Jianxin; Wang, Kai

2012-01-01

The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs).......The authors used a genome-wide association study (GWAS) of multiply affected families to investigate the association of schizophrenia to common single-nucleotide polymorphisms (SNPs) and rare copy number variants (CNVs)....

Association Study of Three Gene Polymorphisms Recently Identified by a Genome-Wide Association Study with Obesity-Related Phenotypes in Chinese Children.

Science.gov (United States)

Song, Qi-Ying; Song, Jie-Yun; Wang, Yang; Wang, Shuo; Yang, Yi-De; Meng, Xiang-Rui; Ma, Jun; Wang, Hai-Jun; Wang, Yan

2017-01-01

This study aimed to examine associations of three single-nucleotide polymorphisms (SNPs) with obesity-related phenotypes in Chinese children. These SNPs were identified by a recent genome-wide association (GWA) study among European children. Given that varied genetic backgrounds across different ethnicity may result in different association, it is necessary to study these associations in a different ethnic population. A total of 3,922 children, including 2,191 normal-weight, 873 overweight and 858 obese children, from three independent studies were included in the study. Logistic and linear regressions were performed, and meta-analyses were conducted to assess the associations between the SNPs and obesity-related phenotypes. The pooled odds ratios of the A-allele of rs564343 in PACS1 for obesity and severe obesity were 1.180 (p = 0.03) and 1.312 (p = 0.004), respectively. We also found that rs564343 was nominally associated with BMI, BMI standard deviation score (BMI-SDS), waist circumference, and waist-to-height ratio (p obesity in a non-European population. This SNP was also found to be associated with common obesity and various obesity-related phenotypes in Chinese children, which had not been reported in the original study. The results demonstrated the value of conducting genetic researches in populations with different ethnicity. © 2017 The Author(s) Published by S. Karger GmbH, Freiburg.

Music in Korean shaman ritual.

OpenAIRE

Mills, Simon R.S.

2012-01-01

It is hard to sum up Korean Shamanism in a few sentences but, in short, it could be described as the traditional syncretic folk religion of Korea. It mixes together ritual practices, beliefs, symbols and myths from Buddhism, Taoism, and folklore and adds elements commonly associated with nature religions and shamanism – including the use of techniques such as divination, trance, and mediumship. As with many other syncretic folk religions around the globe, there is very little in the way o...

Evaluation of anticonvulsant activity of methanol leaf extract of ...

African Journals Online (AJOL)

Hymenocardia acida is a plant used in African folkloric medicine in the treatment of headache, rheumatic pain, sickle cell crisis, malaria, epilepsy and cancer. This study was aimed at investigating the anticonvulsant potential of the methanol leaf extract of H. acida (MLEHA) in chicks and mice. Preliminary phytochemical ...

Wound healing properties of ointment formulations of Ocimum ...

African Journals Online (AJOL)

present work evaluated the phyto-constituents and wound healing properties of ointments formulated with the n-hexane crude bark extract of a plant used folklorically in wound healing, Ocimum gratissimum. The excision wound model was employed in the wound healing studies. The air-dried, size-reduced barks were ...

Evaluation of the toxicity and reversibility profile of the aqueous seed ...

African Journals Online (AJOL)

Hunteria umbellata (K. Schum.) Hallier f. (family: Apocynaceae) is reputed for the folkloric management of labour, pain and swellings, stomach ulcers, diabetes, obesity, and anaemia, with no scientific report of its toxicity and reversibility profile. The present study was, therefore, aimed at investigating the in vivo toxicity and ...

Hudební typologie tanečních nápěvů českých lidových písní (na příkladu Erbenovy sbírky)

Czech Academy of Sciences Publication Activity Database

Vejvoda, Zdeněk

2017-01-01

Roč. 54, č. 3 (2017), s. 319-362 ISSN 0018-7003 R&D Projects: GA ČR(CZ) GA15-24418S Institutional support: RVO:68378076 Keywords : folk music * structural analysis * Karel Jaromír Erben Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Folklore studies

Vladimír Helfert ve Státním ústavu pro lidovou píseň

Czech Academy of Sciences Publication Activity Database

Procházková, Jarmila

2016-01-01

Roč. 51, č. 2 (2016), s. 137-154 ISSN 1212-0391 Institutional support: RVO:68378076 Keywords : Vladimír Helfert (1886-1945) * Leoš Janáček (1854-1928) * State Institute for Folk Song * folklore studies * politics and music Subject RIV: AL - Art, Architecture, Cultural Heritage

Básník a lid. Bedřich Václavek mezi literaturou a folklorem

Czech Academy of Sciences Publication Activity Database

Feinberg, Joseph Grim

2017-01-01

Roč. 65, č. 6 (2017), s. 823-845 ISSN 0009-0468 R&D Projects: GA ČR(CZ) GA17-23955S Institutional support: RVO:67985955 Keywords : Marxism * interwar literary criticism * literary criticism * folklore studies * avant-garde Subject RIV: AJ - Letters, Mass-media, Audiovision OBOR OECD: Literary theory

Genome-wide association study identifies variants associated with autoimmune hepatitis type 1.

Science.gov (United States)

de Boer, Ynto S; van Gerven, Nicole M F; Zwiers, Antonie; Verwer, Bart J; van Hoek, Bart; van Erpecum, Karel J; Beuers, Ulrich; van Buuren, Henk R; Drenth, Joost P H; den Ouden, Jannie W; Verdonk, Robert C; Koek, Ger H; Brouwer, Johannes T; Guichelaar, Maureen M J; Vrolijk, Jan M; Kraal, Georg; Mulder, Chris J J; van Nieuwkerk, Carin M J; Fischer, Janett; Berg, Thomas; Stickel, Felix; Sarrazin, Christoph; Schramm, Christoph; Lohse, Ansgar W; Weiler-Normann, Christina; Lerch, Markus M; Nauck, Matthias; Völzke, Henry; Homuth, Georg; Bloemena, Elisabeth; Verspaget, Hein W; Kumar, Vinod; Zhernakova, Alexandra; Wijmenga, Cisca; Franke, Lude; Bouma, Gerd

2014-08-01

Autoimmune hepatitis (AIH) is an uncommon autoimmune liver disease of unknown etiology. We used a genome-wide approach to identify genetic variants that predispose individuals to AIH. We performed a genome-wide association study of 649 adults in The Netherlands with AIH type 1 and 13,436 controls. Initial associations were further analyzed in an independent replication panel comprising 451 patients with AIH type 1 in Germany and 4103 controls. We also performed an association analysis in the discovery cohort using imputed genotypes of the major histocompatibility complex region. We associated AIH with a variant in the major histocompatibility complex region at rs2187668 (P = 1.5 × 10(-78)). Analysis of this variant in the discovery cohort identified HLA-DRB1*0301 (P = 5.3 × 10(-49)) as a primary susceptibility genotype and HLA-DRB1*0401 (P = 2.8 × 10(-18)) as a secondary susceptibility genotype. We also associated AIH with variants of SH2B3 (rs3184504, 12q24; P = 7.7 × 10(-8)) and CARD10 (rs6000782, 22q13.1; P = 3.0 × 10(-6)). In addition, strong inflation of association signal was found with single-nucleotide polymorphisms associated with other immune-mediated diseases, including primary sclerosing cholangitis and primary biliary cirrhosis, but not with single-nucleotide polymorphisms associated with other genetic traits. In a genome-wide association study, we associated AIH type 1 with variants in the major histocompatibility complex region, and identified variants of SH2B3and CARD10 as likely risk factors. These findings support a complex genetic basis for AIH pathogenesis and indicate that part of the genetic susceptibility overlaps with that for other immune-mediated liver diseases. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

Perancangan Komunikasi Visual Film Animasi Pendek “Sitiha dan Sisiti”

Directory of Open Access Journals (Sweden)

Fenny Wijaya

2010-10-01

Full Text Available The purpose of this research is to acquire, collect and analyze data needed to realize the design of short animated 3D films with a folklore theme which is presented  with a visually appeal to interest spectators, especially children, so the moral message can be conveyed. The research method is to survey directly to the field, namely the cultural center of Indonesia TMII, playground and library. In addition to the literature media such as books, magazines and journals and supported with references from the internet media relating to the topic. Results to be achieved are for the moral message conveyed in this animated folklore film can be received and understood by the audience, especially children. Conclusion at the present time, visual communications media such as movies and television shows are very popular among children. So by using the medium of animated films, children will be more interested and may like local folklore again, since local productions are not of lesser quality than the outside impressions. 

SNP association study in PMS2-associated Lynch syndrome.

Science.gov (United States)

Ten Broeke, Sanne W; Elsayed, Fadwa A; Pagan, Lisa; Olderode-Berends, Maran J W; Garcia, Encarna Gomez; Gille, Hans J P; van Hest, Liselot P; Letteboer, Tom G W; van der Kolk, Lizet E; Mensenkamp, Arjen R; van Os, Theo A; Spruijt, Liesbeth; Redeker, Bert J W; Suerink, Manon; Vos, Yvonne J; Wagner, Anja; Wijnen, Juul T; Steyerberg, E W; Tops, Carli M J; van Wezel, Tom; Nielsen, Maartje

2017-11-17

Lynch syndrome (LS) patients are at high risk of developing colorectal cancer (CRC). Phenotypic variability might in part be explained by common susceptibility loci identified in Genome Wide Association Studies (GWAS). Previous studies focused mostly on MLH1, MSH2 and MSH6 carriers, with conflicting results. We aimed to determine the role of GWAS SNPs in PMS2 mutation carriers. A cohort study was performed in 507 PMS2 carriers (124 CRC cases), genotyped for 24 GWAS SNPs, including SNPs at 11q23.1 and 8q23.3. Hazard ratios (HRs) were calculated using a weighted Cox regression analysis to correct for ascertainment bias. Discrimination was assessed with a concordance statistic in a bootstrap cross-validation procedure. Individual SNPs only had non-significant associations with CRC occurrence with HRs lower than 2, although male carriers of allele A at rs1321311 (6p21.31) may have increased risk of CRC (HR = 2.1, 95% CI 1.2-3.0). A polygenic risk score (PRS) based on 24 HRs had an HR of 2.6 (95% CI 1.5-4.6) for the highest compared to the lowest quartile, but had no discriminative ability (c statistic 0.52). Previously suggested SNPs do not modify CRC risk in PMS2 carriers. Future large studies are needed for improved risk stratification among Lynch syndrome patients.

Genome-wide association study of serum selenium concentrations

DEFF Research Database (Denmark)

Gong, Jian; Hsu, Li; Harrison, Tabitha

2013-01-01

Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated...... this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women’s Health Initiative (WHI). We...... tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p

Analgesic activity of crude aqueous extract of the root bark of ...

African Journals Online (AJOL)

Objective: The analgesic activity of crude aqueous extract of the root bark of Zanthoxylum xanthozyloides was studied in mice and rats with the view to verifying the claim in folklore medicine that the extract has analgesic activity. Method: The extract was obtained by Soxhlet extraction and rotatory evaporation, followed by ...

The Visual Narrative: Kids, Comic Books, and Creativity.

Science.gov (United States)

Hoff, Gary R.

1982-01-01

Discusses why junior high school students like comic books and examines how comic book art and visual narrative can be used in education. Copying comic book art can teach students several useful art techniques. Suggestions for using visual narratives to study science fiction, literature, folklore, and art history are included. (AM)

Anti-inflammatory of both Eucalyptus spp. and Pistascia lentiscus ...

African Journals Online (AJOL)

Background: Eucalyptus spp. and Pistascia lentiscus are among the Palestinian trees that are traditionally used in folkloric medicine in treating many diseases; leaves of which are thought to have anti-inflammatory, antibacterial and antioxidant effects. The goal of this study is to evaluate the in vitro inhibitory effect of ...

Internetová databáze kramářských tisků Etnologického ústavu Akademie věd České republiky, v. v. i. v Praze

Czech Academy of Sciences Publication Activity Database

Holubová, Markéta

2017-01-01

Roč. 5, č. 1 (2017), s. 147-158 ISSN 1339-2204 Grant - others:AV ČR(CZ) StrategieAV21/12 Program:StrategieAV Institutional support: RVO:68378076 Keywords : popular culture * Czechia * chapbooks * broadsides ballads * electronic databases * format MARC 21 Subject RIV: AC - Archeology, Anthropology, Ethnology OBOR OECD: Folklore studies

Evaluation of Antibacterial Activity of Prosopis Juliflora (Sw.) Dc ...

African Journals Online (AJOL)

Background: The ethnobotanical importance of Prosopis juliflora is well-known in the folkloric system of medicine for the treatment of various ailments. Although, the study related to the antibacterial potential of this plant, from Central India is scanty. Material and methods: The in vitro antibacterial activity of Prosopis juliflora ...

Compactness and contradiction

CERN Document Server

Tao, Terence

2013-01-01

There are many bits and pieces of folklore in mathematics that are passed down from advisor to student, or from collaborator to collaborator, but which are too fuzzy and nonrigorous to be discussed in the formal literature. Traditionally, it was a matter of luck and location as to who learned such "folklore mathematics". But today, such bits and pieces can be communicated effectively and efficiently via the semiformal medium of research blogging. This book grew from such a blog. The articles, essays, and notes in this book are derived from the author's mathematical blog in 2010. It contains a

An epsilon of room, II pages from year three of a mathematical blog

CERN Document Server

Tao, Terence

2011-01-01

There are many bits and pieces of folklore in mathematics that are passed down from advisor to student, or from collaborator to collaborator, but which are too fuzzy and nonrigorous to be discussed in the formal literature. Traditionally, it was a matter of luck and location as to who learned such "folklore mathematics". But today, such bits and pieces can be communicated effectively and efficiently via the semiformal medium of research blogging. This book grew from such a blog. In 2007 Terry Tao began a mathematical blog to cover a variety of topics, ranging from his own research and other re

Poincaré's legacies, part I pages from year two of a mathematical blog

CERN Document Server

Tao, Terence

2009-01-01

There are many bits and pieces of folklore in mathematics that are passed down from advisor to student, or from collaborator to collaborator, but which are too fuzzy and non-rigorous to be discussed in the formal literature. Traditionally, it was a matter of luck and location as to who learned such folklore mathematics. But today, such bits and pieces can be communicated effectively and efficiently via the semiformal medium of research blogging. This book grew from such a blog. In 2007, Terry Tao began a mathematical blog to cover a variety of topics, ranging from his own research and other re

Poincaré's legacies, part II pages from year two of a mathematical blog

CERN Document Server

Tao, Terence

2009-01-01

There are many bits and pieces of folklore in mathematics that are passed down from advisor to student, or from collaborator to collaborator, but which are too fuzzy and non-rigorous to be discussed in the formal literature. Traditionally, it was a matter of luck and location as to who learned such folklore mathematics. But today, such bits and pieces can be communicated effectively and efficiently via the semiformal medium of research blogging. This book grew from such a blog. In 2007, Terry Tao began a mathematical blog to cover a variety of topics, ranging from his own research and other re

Multivariate Methods for Meta-Analysis of Genetic Association Studies.

Science.gov (United States)

Dimou, Niki L; Pantavou, Katerina G; Braliou, Georgia G; Bagos, Pantelis G

2018-01-01

Multivariate meta-analysis of genetic association studies and genome-wide association studies has received a remarkable attention as it improves the precision of the analysis. Here, we review, summarize and present in a unified framework methods for multivariate meta-analysis of genetic association studies and genome-wide association studies. Starting with the statistical methods used for robust analysis and genetic model selection, we present in brief univariate methods for meta-analysis and we then scrutinize multivariate methodologies. Multivariate models of meta-analysis for a single gene-disease association studies, including models for haplotype association studies, multiple linked polymorphisms and multiple outcomes are discussed. The popular Mendelian randomization approach and special cases of meta-analysis addressing issues such as the assumption of the mode of inheritance, deviation from Hardy-Weinberg Equilibrium and gene-environment interactions are also presented. All available methods are enriched with practical applications and methodologies that could be developed in the future are discussed. Links for all available software implementing multivariate meta-analysis methods are also provided.

Genome-wide association study identifies genetic loci associated with iron deficiency.

Directory of Open Access Journals (Sweden)

Christine E McLaren

2011-03-01

Full Text Available The existence of multiple inherited disorders of iron metabolism in man, rodents and other vertebrates suggests genetic contributions to iron deficiency. To identify new genomic locations associated with iron deficiency, a genome-wide association study (GWAS was performed using DNA collected from white men aged≥25 y and women≥50 y in the Hemochromatosis and Iron Overload Screening (HEIRS Study with serum ferritin (SF≤12 µg/L (cases and iron replete controls (SF>100 µg/L in men, SF>50 µg/L in women. Regression analysis was used to examine the association between case-control status (336 cases, 343 controls and quantitative serum iron measures and 331,060 single nucleotide polymorphism (SNP genotypes, with replication analyses performed in a sample of 71 cases and 161 controls from a population of white male and female veterans screened at a US Veterans Affairs (VA medical center. Five SNPs identified in the GWAS met genome-wide statistical significance for association with at least one iron measure, rs2698530 on chr. 2p14; rs3811647 on chr. 3q22, a known SNP in the transferrin (TF gene region; rs1800562 on chr. 6p22, the C282Y mutation in the HFE gene; rs7787204 on chr. 7p21; and rs987710 on chr. 22q11 (GWAS observed P<1.51×10(-7 for all. An association between total iron binding capacity and SNP rs3811647 in the TF gene (GWAS observed P=7.0×10(-9, corrected P=0.012 was replicated within the VA samples (observed P=0.012. Associations with the C282Y mutation in the HFE gene also were replicated. The joint analysis of the HEIRS and VA samples revealed strong associations between rs2698530 on chr. 2p14 and iron status outcomes. These results confirm a previously-described TF polymorphism and implicate one potential new locus as a target for gene identification.

The Developmental Pattern of Resistance to Peer Influence in Adolescence: Will the Teenager Ever Be Able to Resist?

Science.gov (United States)

Sumter, Sindy R.; Bokhorst, Caroline L.; Steinberg, Laurence; Westenberg, P. Michiel

2009-01-01

Common folklore seems to suggest that adolescents are particularly susceptible to peer influence. However, from the literature the exact age differences in susceptibility to peer influence remain unclear. The current study's main focus was to chart the development of general susceptibility to peer pressure in a community sample of 10-18 year olds…

Effects of Resin and Essential Oil from Commiphora myrrha Engl. on ...

African Journals Online (AJOL)

The oleo-gum-resin of Commiphora myrrha (Nees) Engl (syn. Commiphora molmol (Engl.) Engl. ex Tschirch) is used in the Ethiopian folkloric medicine for wound management. The present study was aimed at evaluating the wound healing properties of the essential oil and resin of C. myrrha using in vivo and in vitro ...

Genome-wide association study identifies 74 loci associated with educational attainment

DEFF Research Database (Denmark)

Okbay, Aysu; P. Beauchamp, Jonathan; Alan Fontana, Mark

2016-01-01

-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural......Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals1. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends...... development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals...

Genome-wide association study identifies variants in HORMAD2 associated with tonsillectomy

DEFF Research Database (Denmark)

Feenstra, Bjarke; Bager, Peter; Liu, Xueping

2017-01-01

BACKGROUND: Inflammation of the tonsils is a normal response to infection, but some individuals experience recurrent, severe tonsillitis and massive hypertrophy of the tonsils in which case surgical removal of the tonsils may be considered. OBJECTIVE: To identify common genetic variants associate...... the molecular mechanisms underlying the genetic association involve general lymphoid hyper-reaction throughout the mucosa-associated lymphoid tissue system.......BACKGROUND: Inflammation of the tonsils is a normal response to infection, but some individuals experience recurrent, severe tonsillitis and massive hypertrophy of the tonsils in which case surgical removal of the tonsils may be considered. OBJECTIVE: To identify common genetic variants associated...... with tonsillectomy. METHODS: We used tonsillectomy information from Danish health registers and carried out a genome-wide association study comprising 1464 patients and 12 019 controls of Northwestern European ancestry, with replication in an independent sample set of 1575 patients and 1367 controls. RESULTS...

Genome-wide Association Study of Personality Traits in the Long Life Family Study

Directory of Open Access Journals (Sweden)

Harold T Bae

2013-05-01

Full Text Available Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS on personality factors assessed by NEO-FFI in individuals enrolled in the Long Life Family Study (LLFS, a study of 583 families (N up to 4595 with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p<10-8 and replicated in an additional sample of 1279 LLFS subjects, although one (rs9650241 failed to replicate and the other two were not available in two independent replication cohorts, the Baltimore Longitudinal Study of Aging and the New England Centenarian Study. Based on 10,000,000 permutations, the empirical p-value of 2X10-7 was observed for the genome-wide significant SNPs. Seventeen SNPs that reached marginal statistical significance in the two previous GWASs (p-value < 10-4 and 10-5, were also marginally significantly associated in this study (p-value < 0.05, although none of the associations passed the Bonferroni correction. In addition, we tested age-by-SNP interactions and found some significant associations. Since scores of personality traits in LLFS subjects change in the oldest ages, and genetic factors outweigh environmental factors to achieve extreme ages, these age-by-SNP interactions could be a proxy for complex gene-gene interactions affecting personality traits and longevity.

The Art of Mexico.

Science.gov (United States)

Saccardi, Marianne

1997-01-01

Provides an annotated bibliography of books for grades K and up which explores the folklore, poetry, fiction, and art of Mexico, and focuses on the Mayans and Aztecs and Diego Rivera and Frida Kahlo. Also suggests various research, reading, drama, music, social studies, physical education, and art activities and lists related videos and Internet…

Considerations for Pharmacoepidemiological Studies of Drug-Cancer Associations

DEFF Research Database (Denmark)

Pottegård, Anton; Friis, Søren; Stürmer, Til

2018-01-01

and future perspectives. Aspects of data sources include assessment of complete history of drug use and data on dose and duration of drug use, allowing estimates of cumulative exposure. Outcome data from formal cancer registries are preferable, but cancer data from other sources, for example, patient......In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment...... or pathology registries, medical records or claims are also suitable. The two principal designs for observational studies evaluating drug-cancer associations are the cohort and case-control designs. A key challenge in studies of drug-cancer associations is the exposure assessment due to the typically long...

The Value in Verifying Medical Folklore

Directory of Open Access Journals (Sweden)

Dennis J. Baumgardner

2017-08-01

Full Text Available Citing a related article published within this issue of the Journal of Patient-Centered Research and Reviews, the author opines on why traditional ideas regarding human health can persist over decades, and even centuries, despite a lack of scientifically accumulated evidence. It is important to keep in mind that some commonly accepted truths are supported by little to no factual data, and that occasionally patients may benefit from clarification on what is (or, often, is not actually known about longstanding “rules of thumb” (eg, certain home remedies, disease-prevention measures or behavioral concerns. On the flip side, traditions that are shown to be not harmful, like drinking chicken soup to relieve cold symptoms, may be safely indulged regardless of effectiveness.

The folklore medicinal orchids of Sikkim

Directory of Open Access Journals (Sweden)

Ashok Kumar Panda

2013-01-01

Results and Conclusion: We found that 36 species of orchids are used as medicines for different purposes of health. The botanical and ayurvedic name, phenology, parts used and medicinal uses of 36 orchids are presented in this paper along with its local distribution.

Genome-wide population-based association study of extremely overweight young adults--the GOYA study

DEFF Research Database (Denmark)

Paternoster, Lavinia; Evans, David M; Nohr, Ellen Aagaard

2011-01-01

Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight...

Adiponectin Concentrations: A Genome-wide Association Study

OpenAIRE

Jee, Sun Ha; Sull, Jae Woong; Lee, Jong-Eun; Shin, Chol; Park, Jongkeun; Kimm, Heejin; Cho, Eun-Young; Shin, Eun-Soon; Yun, Ji Eun; Park, Ji Wan; Kim, Sang Yeun; Lee, Sun Ju; Jee, Eun Jung; Baik, Inkyung; Kao, Linda

2010-01-01

Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP a...

Environmental Hermeneutics: Ethnic and Ecological Traditions in Aesthetic Dialogue with Nature

Directory of Open Access Journals (Sweden)

Boldonova Irina

2016-01-01

Full Text Available The article presents dialogic attitude towards nature and focuses on the aesthetic form of interaction with environment via folklore and imaginative writing. The article analyzes the development of scientific thought from human ecology to environmental hermeneutics. Hermeneutic methodology is used in the field of “aesthetics of nature”, therefore, the author applies hermeneutic categories such as tradition, historically effective consciousness, hermeneutic circle, application to cultural heritage of one of Siberia’s natives and proves the advantages, heuristic value of these categories in analyzing dialogue with nature. Aesthetic dialogue with nature is studied on the example of ethnic and ecological traditions of the Buryat nomads, who historically migrated across Central Asia, nowadays live around Lake Baikal. The author argues that revitalizing ethnic and ecological traditions in folklore and contemporary national literature presents a hermeneutic dialogue with nature and considers it a valuable resource for ethical assumptions and ecological education for sustainable development.

Structure and randomness pages from year one of a mathematical blog

CERN Document Server

Tao, Terence

2009-01-01

There are many bits and pieces of folklore in mathematics that are passed down from advisor to student, or from collaborator to collaborator, but which are too fuzzy and non-rigorous to be discussed in the formal literature. Traditionally, it was a matter of luck and location as to who learned such folklore mathematics. But today, such bits and pieces can be communicated effectively and efficiently via the semiformal medium of research blogging. This book grew from such a blog. In 2007, Terry Tao began a mathematical blog, as an outgrowth of his own website at UCLA. This book is based on a sel

Danish Folkloristics: between Philology and Ethnology

OpenAIRE

Simonsen, Michèle

2014-01-01

Aquest article ofereix una visió general dels estudiosos més importants del folklore danès —Svend Grundtvig, Axel Olrik, Evald Tang Kristensen, Bengt Holbek, Iørn Piø— i sosté que, encara que la majoria d’ells van ser formats originalment en filologia i sobretot es van interessar per la literatura oral, estaven tots, cadascú a la seva manera, d’acord amb l’«ecologia» del folklore: és a dir, la seva interacció amb l’entorn. Què era el «poble» (folk) i què era la «saviesa» (lore) per a aq...

Tall Tales: The Simpsons deconstructing the american myth

Directory of Open Access Journals (Sweden)

Hanna Betina Götz

2014-07-01

Full Text Available This article aims to analyze the episode Tall Tales from the series The Simpsons that revisits legends of the American folklore. The TV series pays homage to both the time of the pioneers in their travels to the Far West in the nineteenth century, as well as to one of the most iconic and folk characters of the American culture from that period: the Hobo was a beggar, a figure of the American folklore during the Great Depression. It is also interesting to focus on the American imaginary in order to understand how the authors of The Simpsons perform these recreations in contemporary times

Genome-wide association study of pathological gambling.

Science.gov (United States)

Lang, M; Leménager, T; Streit, F; Fauth-Bühler, M; Frank, J; Juraeva, D; Witt, S H; Degenhardt, F; Hofmann, A; Heilmann-Heimbach, S; Kiefer, F; Brors, B; Grabe, H-J; John, U; Bischof, A; Bischof, G; Völker, U; Homuth, G; Beutel, M; Lind, P A; Medland, S E; Slutske, W S; Martin, N G; Völzke, H; Nöthen, M M; Meyer, C; Rumpf, H-J; Wurst, F M; Rietschel, M; Mann, K F

2016-08-01

Pathological gambling is a behavioural addiction with negative economic, social, and psychological consequences. Identification of contributing genes and pathways may improve understanding of aetiology and facilitate therapy and prevention. Here, we report the first genome-wide association study of pathological gambling. Our aims were to identify pathways involved in pathological gambling, and examine whether there is a genetic overlap between pathological gambling and alcohol dependence. Four hundred and forty-five individuals with a diagnosis of pathological gambling according to the Diagnostic and Statistical Manual of Mental Disorders were recruited in Germany, and 986 controls were drawn from a German general population sample. A genome-wide association study of pathological gambling comprising single marker, gene-based, and pathway analyses, was performed. Polygenic risk scores were generated using data from a German genome-wide association study of alcohol dependence. No genome-wide significant association with pathological gambling was found for single markers or genes. Pathways for Huntington's disease (P-value=6.63×10(-3)); 5'-adenosine monophosphate-activated protein kinase signalling (P-value=9.57×10(-3)); and apoptosis (P-value=1.75×10(-2)) were significant. Polygenic risk score analysis of the alcohol dependence dataset yielded a one-sided nominal significant P-value in subjects with pathological gambling, irrespective of comorbid alcohol dependence status. The present results accord with previous quantitative formal genetic studies which showed genetic overlap between non-substance- and substance-related addictions. Furthermore, pathway analysis suggests shared pathology between Huntington's disease and pathological gambling. This finding is consistent with previous imaging studies. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Association Between Coronary Artery Disease Genetic Variants and Subclinical Atherosclerosis: An Association Study and Meta-analysis.

Science.gov (United States)

Zabalza, Michel; Subirana, Isaac; Lluis-Ganella, Carla; Sayols-Baixeras, Sergi; de Groot, Eric; Arnold, Roman; Cenarro, Ana; Ramos, Rafel; Marrugat, Jaume; Elosua, Roberto

2015-10-01

Recent studies have identified several genetic variants associated with coronary artery disease. Some of these genetic variants are not associated with classical cardiovascular risk factors and the mechanism of such associations is unclear. The aim of the study was to determine whether these genetic variants are related to subclinical atherosclerosis measured by carotid intima media thickness, carotid stiffness, and ankle brachial index. A cross-sectional study nested in the follow-up of the REGICOR cohort was undertaken. The study included 2667 individuals. Subclinical atherosclerosis measurements were performed with standardized methods. Nine genetic variants were genotyped to assess associations with subclinical atherosclerosis, individually and in a weighted genetic risk score. A systematic review and meta-analysis of previous studies that analyzed these associations was undertaken. Neither the selected genetic variants nor the genetic risk score were significantly associated with subclinical atherosclerosis. In the meta-analysis, the rs1746048 (CXCL12; n = 10581) risk allele was directly associated with carotid intima-media thickness (β = 0.008; 95% confidence interval, 0.001-0.015), whereas the rs6725887 (WDR12; n = 7801) risk allele was inversely associated with this thickness (β = -0.013; 95% confidence interval, -0.024 to -0.003). The analyzed genetic variants seem to mediate their association with coronary artery disease through different mechanisms. Our results generate the hypothesis that the CXCL12 variant appears to influence coronary artery disease risk through arterial remodeling and thickening, whereas the WDR12 risk variant could be related to higher plaque vulnerability. Copyright © 2014 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

Adiponectin Concentrations: A Genome-wide Association Study

Science.gov (United States)

Jee, Sun Ha; Sull, Jae Woong; Lee, Jong-Eun; Shin, Chol; Park, Jongkeun; Kimm, Heejin; Cho, Eun-Young; Shin, Eun-Soon; Yun, Ji Eun; Park, Ji Wan; Kim, Sang Yeun; Lee, Sun Ju; Jee, Eun Jung; Baik, Inkyung; Kao, Linda; Yoon, Sungjoo Kim; Jang, Yangsoo; Beaty, Terri H.

2010-01-01

Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10−15 in the initial sample, p = 6.58 × 10−39 in the second genome-wide sample, and p = 2.12 × 10−32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10−83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10−58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults. PMID:20887962

„Nebyl nikterak citlivůstkářem ani básníkem, jehož svět uzavírá se v komnatě…“ Počátky českého poznávání osobnosti a díla Petka Račova Slavejkova\

Czech Academy of Sciences Publication Activity Database

Černý, Marcel

2016-01-01

Roč. 2, Č. 2 (2016), s. 57-85 E-ISSN 2336-6699 Institutional support: RVO:68378017 Keywords : Czech-Bulgarian cultural relations * Folklore studies * Literary reception * Artistic translation * Bulgarian national revival * Albanians Subject RIV: AJ - Letters, Mass-media, Audiovision http://sites.ff.cuni.cz/studiaethnologicapragensia/wp-content/uploads/sites/3/2017/01/marcel_cerny_57-85.pdf

New progress of the study on uranium-gold association

International Nuclear Information System (INIS)

Feng Mingyue; Sun Zhifu

1992-01-01

Through the study on heavy minerals from the uraniferous granite-pegmatite it is found that nature gold is associated with uraninite, which provides the new information for the study on uranium-gold association and its metallogenesis

New progress of the study on uranium-gold association

Energy Technology Data Exchange (ETDEWEB)

Mingyue, Feng; Zhifu, Sun [Beijing Research Inst. of Uranium Geology (China)

1992-07-01

Through the study on heavy minerals from the uraniferous granite-pegmatite it is found that nature gold is associated with uraninite, which provides the new information for the study on uranium-gold association and its metallogenesis.

Genome-wide association study identifies 74 loci associated with educational attainment

Science.gov (United States)

Okbay, Aysu; Beauchamp, Jonathan P.; Fontana, Mark A.; Lee, James J.; Pers, Tune H.; Rietveld, Cornelius A.; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S. Fleur W.; Oskarsson, Sven; Pickrell, Joseph K.; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S.; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda; Brandsma, Johannes H.; Concas, Maria Pina; Derringer, Jaime; Furlotte, Nicholas A.; Galesloot, Tessel E.; Girotto, Giorgia; Gupta, Richa; Hall, Leanne M.; Harris, Sarah E.; Hofer, Edith; Horikoshi, Momoko; Huffman, Jennifer E.; Kaasik, Kadri; Kalafati, Ioanna P.; Karlsson, Robert; Kong, Augustine; Lahti, Jari; van der Lee, Sven J.; de Leeuw, Christiaan; Lind, Penelope A.; Lindgren, Karl-Oskar; Liu, Tian; Mangino, Massimo; Marten, Jonathan; Mihailov, Evelin; Miller, Michael B.; van der Most, Peter J.; Oldmeadow, Christopher; Payton, Antony; Pervjakova, Natalia; Peyrot, Wouter J.; Qian, Yong; Raitakari, Olli; Rueedi, Rico; Salvi, Erika; Schmidt, Börge; Schraut, Katharina E.; Shi, Jianxin; Smith, Albert V.; Poot, Raymond A.; Pourcain, Beate; Teumer, Alexander; Thorleifsson, Gudmar; Verweij, Niek; Vuckovic, Dragana; Wellmann, Juergen; Westra, Harm-Jan; Yang, Jingyun; Zhao, Wei; Zhu, Zhihong; Alizadeh, Behrooz Z.; Amin, Najaf; Bakshi, Andrew; Baumeister, Sebastian E.; Biino, Ginevra; Bønnelykke, Klaus; Boyle, Patricia A.; Campbell, Harry; Cappuccio, Francesco P.; Davies, Gail; De Neve, Jan-Emmanuel; Deloukas, Panos; Demuth, Ilja; Ding, Jun; Eibich, Peter; Eisele, Lewin; Eklund, Niina; Evans68, David M.; Faul, Jessica D.; Feitosa, Mary F.; Forstner, Andreas J.; Gandin, Ilaria; Gunnarsson, Bjarni; Halldórsson, Bjarni V.; Harris, Tamara B.; Heath, Andrew C.; Hocking, Lynne J.; Holliday, Elizabeth G.; Homuth, Georg; Horan, Michael A.; Hottenga, Jouke-Jan; de Jager, Philip L.; Joshi, Peter K.; Jugessur, Astanand; Kaakinen, Marika A.; Kähönen, Mika; Kanoni, Stavroula; Keltigangas-Järvinen, Liisa; Kiemeney, Lambertus A.L.M.; Kolcic, Ivana; Koskinen, Seppo; Kraja, Aldi T.; Kroh, Martin; Kutalik, Zoltan; Latvala, Antti; Launer, Lenore J.; Lebreton, Maël P.; Levinson, Douglas F.; Lichtenstein, Paul; Lichtner, Peter; Liewald, David C.M.; Loukola, Anu; Madden, Pamela A.; Mägi, Reedik; Mäki-Opas, Tomi; Marioni, Riccardo E.; Marques-Vidal, Pedro; Meddens, Gerardus A.; McMahon, George; Meisinger, Christa; Meitinger, Thomas; Milaneschi, Yusplitri; Milani, Lili; Montgomery, Grant W.; Myhre, Ronny; Nelson, Christopher P.; Nyholt, Dale R.; Ollier, William E.R.; Palotie, Aarno; Paternoster, Lavinia; Pedersen, Nancy L.; Petrovic, Katja E.; Porteous, David J.; Räikkönen, Katri; Ring, Susan M.; Robino, Antonietta; Rostapshova, Olga; Rudan, Igor; Rustichini, Aldo; Salomaa, Veikko; Sanders, Alan R.; Sarin, Antti-Pekka; Schmidt, Helena; Scott, Rodney J.; Smith, Blair H.; Smith, Jennifer A.; Staessen, Jan A.; Steinhagen-Thiessen, Elisabeth; Strauch, Konstantin; Terracciano, Antonio; Tobin, Martin D.; Ulivi, Sheila; Vaccargiu, Simona; Quaye, Lydia; van Rooij, Frank J.A.; Venturini, Cristina; Vinkhuyzen, Anna A.E.; Völker, Uwe; Völzke, Henry; Vonk, Judith M.; Vozzi, Diego; Waage, Johannes; Ware, Erin B.; Willemsen, Gonneke; Attia, John R.; Bennett, David A.; Berger, Klaus; Bertram, Lars; Bisgaard, Hans; Boomsma, Dorret I.; Borecki, Ingrid B.; Bultmann, Ute; Chabris, Christopher F.; Cucca, Francesco; Cusi, Daniele; Deary, Ian J.; Dedoussis, George V.; van Duijn, Cornelia M.; Eriksson, Johan G.; Franke, Barbara; Franke, Lude; Gasparini, Paolo; Gejman, Pablo V.; Gieger, Christian; Grabe, Hans-Jörgen; Gratten, Jacob; Groenen, Patrick J.F.; Gudnason, Vilmundur; van der Harst, Pim; Hayward, Caroline; Hinds, David A.; Hoffmann, Wolfgang; Hyppönen, Elina; Iacono, William G.; Jacobsson, Bo; Järvelin, Marjo-Riitta; Jöckel, Karl-Heinz; Kaprio, Jaakko; Kardia, Sharon L.R.; Lehtimäki, Terho; Lehrer, Steven F.; Magnusson, Patrik K.E.; Martin, Nicholas G.; McGue, Matt; Metspalu, Andres; Pendleton, Neil; Penninx, Brenda W.J.H.; Perola, Markus; Pirastu, Nicola; Pirastu, Mario; Polasek, Ozren; Posthuma, Danielle; Power, Christine; Province, Michael A.; Samani, Nilesh J.; Schlessinger, David; Schmidt, Reinhold; Sørensen, Thorkild I.A.; Spector, Tim D.; Stefansson, Kari; Thorsteinsdottir, Unnur; Thurik, A. Roy; Timpson, Nicholas J.; Tiemeier, Henning; Tung, Joyce Y.; Uitterlinden, André G.; Vitart, Veronique; Vollenweider, Peter; Weir, David R.; Wilson, James F.; Wright, Alan F.; Conley, Dalton C.; Krueger, Robert F.; Smith, George Davey; Hofman, Albert; Laibson, David I.; Medland, Sarah E.; Meyer, Michelle N.; Yang, Jian; Johannesson, Magnus; Visscher, Peter M.; Esko, Tõnu; Koellinger, Philipp D.; Cesarini, David; Benjamin, Daniel J.

2016-01-01

Summary Educational attainment (EA) is strongly influenced by social and other environmental factors, but genetic factors are also estimated to account for at least 20% of the variation across individuals1. We report the results of a genome-wide association study (GWAS) for EA that extends our earlier discovery sample1,2 of 101,069 individuals to 293,723 individuals, and a replication in an independent sample of 111,349 individuals from the UK Biobank. We now identify 74 genome-wide significant loci associated with number of years of schooling completed. Single-nucleotide polymorphisms (SNPs) associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioral phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because EA is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric disease. PMID:27225129

Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

Directory of Open Access Journals (Sweden)

Kraemer Rachel

2009-05-01

Full Text Available Abstract Background We conducted a genome-wide association study (GWAS and validation study for left ventricular (LV mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to identify potential genes with modest effects on left LV mass. We describe here a GWAS for LV mass in Caucasians using the Affymetrix GeneChip Human Mapping 100 k Set. Cases (N = 101 and controls (N = 101 were selected from extreme tails of the LV mass index distribution from 906 individuals in the HyperGEN study. Eleven of 12 promising (Q Results Despite the relatively small sample, we identified 12 promising SNPs in the GWAS. Eleven SNPs were successfully genotyped in the validation study of 704 Caucasians and 1467 African Americans; 5 SNPs on chromosomes 5, 12, and 20 were significantly (P ≤ 0.05 associated with LV mass after correction for multiple testing. One SNP (rs756529 is intragenic within KCNB1, which is dephosphorylated by calcineurin, a previously reported candidate gene for LV hypertrophy within this population. Conclusion These findings suggest KCNB1 may be involved in the development of LV hypertrophy in humans.

Genome-wide association study identifies 74 loci associated with educational attainment

NARCIS (Netherlands)

A. Okbay (Aysu); J.P. Beauchamp (Jonathan); Fontana, M.A. (Mark Alan); J.J. Lee (James J.); T.H. Pers (Tune); Rietveld, C.A. (Cornelius A.); P. Turley (Patrick); Chen, G.-B. (Guo-Bo); V. Emilsson (Valur); Meddens, S.F.W. (S. Fleur W.); Oskarsson, S. (Sven); Pickrell, J.K. (Joseph K.); Thom, K. (Kevin); Timshel, P. (Pascal); R. de Vlaming (Ronald); A. Abdellaoui (Abdel); T.S. Ahluwalia (Tarunveer Singh); J. Bacelis (Jonas); C. Baumbach (Clemens); Bjornsdottir, G. (Gyda); J.H. Brandsma (Johan); Pina Concas, M. (Maria); J. Derringer; Furlotte, N.A. (Nicholas A.); T.E. Galesloot (Tessel); S. Girotto; Gupta, R. (Richa); L.M. Hall (Leanne M.); S.E. Harris (Sarah); E. Hofer; Horikoshi, M. (Momoko); J.E. Huffman (Jennifer E.); Kaasik, K. (Kadri); I.-P. Kalafati (Ioanna-Panagiota); R. Karlsson (Robert); A. Kong (Augustine); J. Lahti (Jari); S.J. van der Lee (Sven); Deleeuw, C. (Christiaan); P.A. Lind (Penelope); Lindgren, K.-O. (Karl-Oskar); Liu, T. (Tian); M. Mangino (Massimo); J. Marten (Jonathan); E. Mihailov (Evelin); M. Miller (Mike); P.J. van der Most (Peter); C. Oldmeadow (Christopher); A. Payton (Antony); N. Pervjakova (Natalia); W.J. Peyrot (Wouter ); Qian, Y. (Yong); O. Raitakari (Olli); Rueedi, R. (Rico); Salvi, E. (Erika); Schmidt, B. (Börge); Schraut, K.E. (Katharina E.); Shi, J. (Jianxin); A.V. Smith (Albert Vernon); R.A. Poot (Raymond); B. St Pourcain (Beate); A. Teumer (Alexander); G. Thorleifsson (Gudmar); N. Verweij (Niek); D. Vuckovic (Dragana); Wellmann, J. (Juergen); H.J. Westra (Harm-Jan); Yang, J. (Jingyun); Zhao, W. (Wei); Zhu, Z. (Zhihong); B.Z. Alizadeh (Behrooz); N. Amin (Najaf); Bakshi, A. (Andrew); S.E. Baumeister (Sebastian); G. Biino (Ginevra); K. Bønnelykke (Klaus); P.A. Boyle (Patricia); H. Campbell (Harry); Cappuccio, F.P. (Francesco P.); G. Davies (Gail); J.E. de Neve (Jan-Emmanuel); P. Deloukas (Panagiotis); I. Demuth (Ilja); Ding, J. (Jun); Eibich, P. (Peter); Eisele, L. (Lewin); N. Eklund (Niina); D.M. Evans (David); J.D. Faul (Jessica D.); M.F. Feitosa (Mary Furlan); A.J. Forstner (Andreas); I. Gandin (Ilaria); Gunnarsson, B. (Bjarni); B.V. Halldorsson (Bjarni); T.B. Harris (Tamara); E.G. Holliday (Elizabeth); A.C. Heath (Andrew C.); L.J. Hocking; G. Homuth (Georg); M. Horan (Mike); J.J. Hottenga (Jouke Jan); P.L. de Jager (Philip); P.K. Joshi (Peter); A. Juqessur (Astanand); M. Kaakinen (Marika); M. Kähönen (Mika); S. Kanoni (Stavroula); Keltigangas-Järvinen, L. (Liisa); L.A.L.M. Kiemeney (Bart); I. Kolcic (Ivana); Koskinen, S. (Seppo); A. Kraja (Aldi); Kroh, M. (Martin); Z. Kutalik (Zoltán); A. Latvala (Antti); L.J. Launer (Lenore); Lebreton, M.P. (Maël P.); D.F. Levinson (Douglas F.); P. Lichtenstein (Paul); P. Lichtner (Peter); D.C. Liewald (David C.); A. Loukola (Anu); P.A. Madden (Pamela); R. Mägi (Reedik); Mäki-Opas, T. (Tomi); R.E. Marioni (Riccardo); P. Marques-Vidal; Meddens, G.A. (Gerardus A.); G. Mcmahon (George); C. Meisinger (Christa); T. Meitinger (Thomas); Milaneschi, Y. (Yusplitri); L. Milani (Lili); G.W. Montgomery (Grant); R. Myhre (Ronny); C.P. Nelson (Christopher P.); D.R. Nyholt (Dale); W.E.R. Ollier (William); A. Palotie (Aarno); L. Paternoster (Lavinia); N.L. Pedersen (Nancy); K. Petrovic (Katja); D.J. Porteous (David J.); K. Räikkönen (Katri); Ring, S.M. (Susan M.); A. Robino (Antonietta); O. Rostapshova (Olga); I. Rudan (Igor); A. Rustichini (Aldo); V. Salomaa (Veikko); Sanders, A.R. (Alan R.); A.-P. Sarin; R. Schmidt (Reinhold); R.J. Scott (Rodney); B.H. Smith (Blair); J.A. Smith (Jennifer A); J.A. Staessen (Jan); E. Steinhagen-Thiessen (Elisabeth); K. Strauch (Konstantin); A. Terracciano; M.D. Tobin (Martin); S. Ulivi (Shelia); S. Vaccargiu (Simona); L. Quaye (Lydia); F.J.A. van Rooij (Frank); C. Venturini (Cristina); A.A.E. Vinkhuyzen (Anna A.); U. Völker (Uwe); Völzke, H. (Henry); J.M. Vonk (Judith); D. Vozzi (Diego); J. Waage (Johannes); E.B. Ware (Erin B.); G.A.H.M. Willemsen (Gonneke); J. Attia (John); D.A. Bennett (David A.); Berger, K. (Klaus); L. Bertram (Lars); H. Bisgaard (Hans); D.I. Boomsma (Dorret); I.B. Borecki (Ingrid); U. Bültmann (Ute); C.F. Chabris (Christopher F.); F. Cucca (Francesco); D. Cusi (Daniele); I.J. Deary (Ian J.); G.V. Dedoussis (George); C.M. van Duijn (Cornelia); K. Hagen (Knut); B. Franke (Barbara); L. Franke (Lude); P. Gasparini (Paolo); P.V. Gejman (Pablo); C. Gieger (Christian); H.J. Grabe (Hans Jörgen); J. Gratten (Jacob); P.J.F. Groenen (Patrick); V. Gudnason (Vilmundur); P. van der Harst (Pim); C. Hayward (Caroline); D.A. Hinds (David A.); W. Hoffmann (Wolfgang); E. Hypponen (Elina); W.G. Iacono (William); B. Jacobsson (Bo); M.-R. Jarvelin (Marjo-Riitta); K.-H. JöCkel (Karl-Heinz); J. Kaprio (Jaakko); S.L.R. Kardia (Sharon); T. Lehtimäki (Terho); Lehrer, S.F. (Steven F.); P.K. Magnusson (Patrik); N.G. Martin (Nicholas); M. McGue (Matt); A. Metspalu (Andres); N. Pendleton (Neil); B.W.J.H. Penninx (Brenda); M. Perola (Markus); N. Pirastu (Nicola); M. Pirastu (Mario); O. Polasek (Ozren); D. Posthuma (Danielle); C. Power (Christopher); M.A. Province (Mike); N.J. Samani (Nilesh); Schlessinger, D. (David); R. Schmidt (Reinhold); T.I.A. Sørensen (Thorkild); T.D. Spector (Timothy); J-A. Zwart (John-Anker); U. Thorsteinsdottir (Unnur); A.R. Thurik (Roy); Timpson, N.J. (Nicholas J.); H.W. Tiemeier (Henning); J.Y. Tung (Joyce Y.); A.G. Uitterlinden (André); Vitart, V. (Veronique); P. Vollenweider (Peter); D.R. Weir (David); J.F. Wilson (James F.); A.F. Wright (Alan); Conley, D.C. (Dalton C.); R.F. Krueger; G.D. Smith; Hofman, A. (Albert); D. Laibson (David); S.E. Medland (Sarah Elizabeth); M.N. Meyer (Michelle N.); J. Yang (Joanna); M. Johannesson (Magnus); P.M. Visscher (Peter); T. Esko (Tõnu); Ph.D. Koellinger (Philipp); D. Cesarini (David); D.J. Benjamin (Daniel J.)

2016-01-01

textabstractEducational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that

Genome-wide association study identifies 74 loci associated with educational attainment

NARCIS (Netherlands)

Okbay, A.; Beauchamp, J.; Fontana, M.A.; Lee, J.J.; Pers, T.H.; Rietveld, C.A.; Turley, P.; Chen, G.B.; Emilsson, V.; Meddens, S.F.W.; de Vlaming, R.; Abdellaoui, A.; Peyrot, W.; Vinkhuyzen, A.A.E.; Hottenga, J.J.; Willemsen, G.; Boomsma, D.I.; Penninx, B.W.J.H.; Laibson, D.; Medland, S.E.; Meyer, M.N.; Yang, J.; Johannesson, M.; Visscher, P.M.; Esko, T.; Koellinger, P.D.; Cesarini, D.; Benjamin, D.J.

2016-01-01

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our

Genome-wide association study identifies 74 loci associated with educational attainment

NARCIS (Netherlands)

Okbay, Aysu; Beauchamp, Jonathan P.; Fontana, Mark Alan; Lee, James J.; Pers, Tune H.; Rietveld, Cornelius A.; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S. Fleur W.; Oskarsson, Sven; Pickrell, Joseph K.; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S.; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda; Brandsma, Johannes H.; Concas, Maria Pina; Derringer, Jaime; Furlotte, Nicholas A.; Galesloot, Tessel E.; Girotto, Giorgia; Gupta, Richa; Hall, Leanne M.; Harris, Sarah E.; Hofer, Edith; Horikoshi, Momoko; Huffman, Jennifer E.; Kaasik, Kadri; Kalafati, Ioanna P.; Karlsson, Robert; Kong, Augustine; Lahti, Jari; van der Lee, Sven J.; de Leeuw, Christiaan; Lind, Penelope A.; Lindgren, Karl-Oskar; Liu, Tian; van der Most, Peter J.; Verweij, Niek; Alizadeh, Behrooz Z.; Vonk, Judith M.; Bultmann, Ute; Franke, Lude; van der Harst, Pim; Penninx, Brenda W. J. H.

2016-01-01

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals(1). Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends

A prevalence-based association test for case-control studies.

Science.gov (United States)

Ryckman, Kelli K; Jiang, Lan; Li, Chun; Bartlett, Jacquelaine; Haines, Jonathan L; Williams, Scott M

2008-11-01

Genetic association is often determined in case-control studies by the differential distribution of alleles or genotypes. Recent work has demonstrated that association can also be assessed by deviations from the expected distributions of alleles or genotypes. Specifically, multiple methods motivated by the principles of Hardy-Weinberg equilibrium (HWE) have been developed. However, these methods do not take into account many of the assumptions of HWE. Therefore, we have developed a prevalence-based association test (PRAT) as an alternative method for detecting association in case-control studies. This method, also motivated by the principles of HWE, uses an estimated population allele frequency to generate expected genotype frequencies instead of using the case and control frequencies separately. Our method often has greater power, under a wide variety of genetic models, to detect association than genotypic, allelic or Cochran-Armitage trend association tests. Therefore, we propose PRAT as a powerful alternative method of testing for association.

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

DEFF Research Database (Denmark)

Evangelou, Evangelos; Kerkhof, Hanneke J; Styrkarsdottir, Unnur

2014-01-01

Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects.......Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects....

Clinical study on antibody-associated limbic encephalitis

Directory of Open Access Journals (Sweden)

WANG Jia-wei

2013-01-01

Full Text Available In recent years, the antibody-associated limbic encephalitis (LE has attracted attentions of more and more clinicians. The associated antibodies mainly act on neuronal cell surface antigens, including the N-methyl-D-aspartate (NMDA receptor, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA receptor, the γ-aminobutyric acid B (GABAB receptor, leucine-rich glioma-inactivated 1 (LGI1 and contactin-associated protein-like 2 (Caspr2 and so on. The clinical manifestation is primarily defined by the subacute onset of short-term memory loss, seizures, confusion and psychiatric symptoms suggesting the involvement of the limbic system. These severe and protracted disorders can affect children and young adults, occurring with or without tumor association. Routine detection of serum and cerebrospinal fluid (CSF and imaging tests show no specificity, but associated antibodies can be detected in serum and (or CSF. The patients respond well to tumor resection and immunotherapies, including corticosteroids, intravenous immunoglobulin (IVIg, plasma exchange or combination of them, but may relapse. This article aims to study the clinical features and treatment of antibody-associated limbic encephalitis and to improve the diagnosis and prognosis of these diseases.

Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C.

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Joanna M Biernacka

Full Text Available Genome-wide association studies (GWAS have revealed many single nucleotide polymorphisms (SNPs associated with complex traits. Although these studies frequently fail to identify statistically significant associations, the top association signals from GWAS may be enriched for true associations. We therefore investigated the association of alcohol dependence with 43 SNPs selected from association signals in the first two published GWAS of alcoholism. Our analysis of 808 alcohol-dependent cases and 1,248 controls provided evidence of association of alcohol dependence with SNP rs1614972 in the ADH1C gene (unadjusted p = 0.0017. Because the GWAS study that originally reported association of alcohol dependence with this SNP [1] included only men, we also performed analyses in sex-specific strata. The results suggest that this SNP has a similar effect in both sexes (men: OR (95%CI = 0.80 (0.66, 0.95; women: OR (95%CI = 0.83 (0.66, 1.03. We also observed marginal evidence of association of the rs1614972 minor allele with lower alcohol consumption in the non-alcoholic controls (p = 0.081, and independently in the alcohol-dependent cases (p = 0.046. Despite a number of potential differences between the samples investigated by the prior GWAS and the current study, data presented here provide additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence and extend this finding by demonstrating association with consumption levels in both non-alcoholic and alcohol-dependent populations. Further studies should investigate the association of other polymorphisms in this gene with alcohol dependence and related alcohol-use phenotypes.

Bayesian Graphical Models for Genomewide Association Studies

OpenAIRE

Verzilli, Claudio J.; Stallard, Nigel; Whittaker, John C.

2006-01-01

As the extent of human genetic variation becomes more fully characterized, the research community is faced with the challenging task of using this information to dissect the heritable components of complex traits. Genomewide association studies offer great promise in this respect, but their analysis poses formidable difficulties. In this article, we describe a computationally efficient approach to mining genotype-phenotype associations that scales to the size of the data sets currently being ...

FORTUNE-TELLING IN THE SEYAHATNAME OF EVLIYA CELEBI EVLİYA ÇELEBİ SEYAHATMESİ’NDE FAL

Directory of Open Access Journals (Sweden)

Elif DÜLGER

2011-12-01

Full Text Available According to the Turkish Folklore Archive Guide prepared in 1976by the National Folklore Research Deparment of Ministry of Culture ofthe time, which is now called the Ministry of Culture directorate generalfor research and development of folk culture, article „K‟ in the guide wasdesignated for beliefs, while the subjects of Turkish folklore was beingdetermined. In this part of the guide which was prepared based on thecategorization in hundreds, dream and fortune-telling appears in the „K700‟ category. As is understood from this information, we come across fortunetellingin the part which is designated for beliefs in folklore. Fortunetellingupon which little study is conducted is a branch of Turkishfolklore -handled in different researches- and it bears importance in thatit shows people‟s approach to supernatural powers.This study is based on assessing information related to fortunetellingwhich was recorded while giving information about various placesin Seyahatname,which is an important work as far as Turkish culturalhistory, literature and folk science is considered. The main aim of ourstudy is to include this important work of our cultural history in theresearches on fortune-telling and to form the basis for the studies that weare going to carry out on fortunetelling on which little research isconducted. 1976 yılında, şimdiki adı Kültür Bakanlığı Halk KültürleriniAraştırma ve Geliştirme Genel Müdürlüğü olan, zamanın KültürBakanlığı Millî Folklor Araştırma Dairesi Başkanlığı tarafındanhazırlanan Türk Folklor Arşiv Kılavuzuna göre Türk folklorunun konularıbelirlenirken kılavuzun “K” maddesi inanışlara ayrılmıştır. 100‟lükkodlama seviyesinde hazırlanan kılavuzun bu bölümünde “K 700”kodlamasında rüya ve fal yer almaktadır.Bu bilgilerden anlaşıldığı üzere fal, folklorun inanışlar bölümündekarşımıza çıkmaktadır. Değişik araştırmalarda ele alınan T�

Genome-wide association study identifies 74 loci associated with educational attainment

OpenAIRE

Okbay, Aysu; Beauchamp, Jonathan; Fontana, M.A. (Mark Alan); Lee, James J.; Pers, Tune; Rietveld, C.A. (Cornelius A.); Turley, Patrick; Chen, G.-B. (Guo-Bo); Emilsson, Valur; Meddens, S.F.W. (S. Fleur W.); Oskarsson, S. (Sven); Pickrell, J.K. (Joseph K.); Thom, K. (Kevin); Timshel, P. (Pascal); Vlaming, Ronald

2016-01-01

textabstractEducational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 geno...

Plutonium uniqueness

International Nuclear Information System (INIS)

Silver, G.L.

1984-01-01

A standard is suggested against which the putative uniqueness of plutonium may be tested. It is common folklore that plutonium is unique among the chemical elements because its four common oxidation states can coexist in the same solution. Whether this putative uniqueness appears only during transit to equilibrium, or only at equilibrium, or all of the time, is not generally made clear. But while the folklore may contain some truth, it cannot be put to test until some measure of 'uniqueness' is agreed upon so that quantitative comparisons are possible. One way of measuring uniqueness is as the magnitude of the product of the mole fractions of the element at equilibrium. A 'coexistence index' is defined and discussed. (author)

Genome-Wide Association Study of Serum Selenium Concentrations

Directory of Open Access Journals (Sweden)

Ulrike Peters

2013-05-01

Full Text Available Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO Cancer Screening and the Women’s Health Initiative (WHI. We tested association between 2,474,333 single nucleotide polymorphisms (SNPs and serum selenium concentrations using linear regression models. In the first stage (PLCO 41 SNPs clustered in 15 regions had p < 1 × 10−5. None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003 in the second stage (WHI. Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11 and had p between 2.62 × 10−7 and 4.04 × 10−7 in the combined analysis (PLCO + WHI. Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.

Genome-Wide Association Study of Antiphospholipid Antibodies

Directory of Open Access Journals (Sweden)

M. Ilyas Kamboh

2013-01-01

Full Text Available Background. The persistent presence of antiphospholipid antibodies (APA may lead to the development of primary or secondary antiphospholipid syndrome. Although the genetic basis of APA has been suggested, the identity of the underlying genes is largely unknown. In this study, we have performed a genome-wide association study (GWAS in an effort to identify susceptibility loci/genes for three main APA: anticardiolipin antibodies (ACL, lupus anticoagulant (LAC, and anti-β2 glycoprotein I antibodies (anti-β2GPI. Methods. DNA samples were genotyped using the Affymetrix 6.0 array containing 906,600 single-nucleotide polymorphisms (SNPs. Association of SNPs with the antibody status (positive/negative was tested using logistic regression under the additive model. Results. We have identified a number of suggestive novel loci with Passociations of HLA genes and APOH with APA but these were not the top loci. Conclusions. We have identified a number of suggestive novel loci for APA that will stimulate follow-up studies in independent and larger samples to replicate our findings.

Genome-wide association study identifies three novel genetic markers associated with elite endurance performance

DEFF Research Database (Denmark)

Ahmetov, Ii; Kulemin, Na; Popov, Dv

2015-01-01

To investigate the association between multiple single-nucleotide polymorphisms (SNPs), aerobic performance and elite endurance athlete status in Russians. By using GWAS approach, we examined the association between 1,140,419 SNPs and relative maximal oxygen consumption rate ([Formula: see text]O2......max) in 80 international-level Russian endurance athletes (46 males and 34 females). To validate obtained results, we further performed case-control studies by comparing the frequencies of the most significant SNPs (with P endurance athletes and opposite cohorts (192...... Russian controls, 1367 European controls, and 230 Russian power athletes). Initially, six 'endurance alleles' were identified showing discrete associations with [Formula: see text]O2max both in males and females. Next, case-control studies resulted in remaining three SNPs (NFIA-AS2 rs1572312, TSHR rs...

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study

International Nuclear Information System (INIS)

Niu, Nifang; Cunningham, Julie M; Li, Liang; Sun, Zhifu; Yang, Ping; Wang, Liewei; Schaid, Daniel J; Abo, Ryan P; Kalari, Krishna; Fridley, Brooke L; Feng, Qiping; Jenkins, Gregory; Batzler, Anthony; Brisbin, Abra G

2012-01-01

Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs) that might contribute to taxane response, we performed a genome-wide association study (GWAS) for two taxanes, paclitaxel and docetaxel, using 276 lymphoblastoid cell lines (LCLs), followed by genotyping of top candidate SNPs in 874 lung cancer patient samples treated with paclitaxel. GWAS was performed using 1.3 million SNPs and taxane cytotoxicity IC50 values for 276 LCLs. The association of selected SNPs with overall survival in 76 small or 798 non-small cell lung cancer (SCLC, NSCLC) patients were analyzed by Cox regression model, followed by integrated SNP-microRNA-expression association analysis in LCLs and siRNA screening of candidate genes in SCLC (H196) and NSCLC (A549) cell lines. 147 and 180 SNPs were associated with paclitaxel or docetaxel IC50s with p-values <10 -4 in the LCLs, respectively. Genotyping of 153 candidate SNPs in 874 lung cancer patient samples identified 8 SNPs (p-value < 0.05) associated with either SCLC or NSCLC patient overall survival. Knockdown of PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, genes within 200 kb up-/downstream of the 3 SNPs that were associated with SCLC overall survival (rs1778335, rs2662411 and rs7519667), significantly desensitized H196 to paclitaxel. SNPs rs2662411 and rs1778335 were associated with mRNA expression of CMBL or PIP4K2A through microRNA (miRNA) hsa-miR-584 or hsa-miR-1468. GWAS in an LCL model system, joined with clinical translational and functional studies, might help us identify genetic variations associated with overall survival of lung cancer patients treated paclitaxel

To Be or Not to Be Associated: Power study of four statistical modeling approaches to identify parasite associations in cross-sectional studies

Directory of Open Access Journals (Sweden)

Elise eVaumourin

2014-05-01

Full Text Available A growing number of studies are reporting simultaneous infections by parasites in many different hosts. The detection of whether these parasites are significantly associated is important in medicine and epidemiology. Numerous approaches to detect associations are available, but only a few provide statistical tests. Furthermore, they generally test for an overall detection of association and do not identify which parasite is associated with which other one. Here, we developed a new approach, the association screening approach, to detect the overall and the detail of multi-parasite associations. We studied the power of this new approach and of three other known ones (i.e. the generalized chi-square, the network and the multinomial GLM approaches to identify parasite associations either due to parasite interactions or to confounding factors. We applied these four approaches to detect associations within two populations of multi-infected hosts: 1 rodents infected with Bartonella sp., Babesia microti and Anaplasma phagocytophilum and 2 bovine population infected with Theileria sp. and Babesia sp.. We found that the best power is obtained with the screening model and the generalized chi-square test. The differentiation between associations, which are due to confounding factors and parasite interactions was not possible. The screening approach significantly identified associations between Bartonella doshiae and B. microti, and between T. parva, T. mutans and T. velifera. Thus, the screening approach was relevant to test the overall presence of parasite associations and identify the parasite combinations that are significantly over- or under-represented. Unravelling whether the associations are due to real biological interactions or confounding factors should be further investigated. Nevertheless, in the age of genomics and the advent of new technologies, it is a considerable asset to speed up researches focusing on the mechanisms driving interactions

Genome-wide association study identifies four loci associated with eruption of permanent teeth

DEFF Research Database (Denmark)

Geller, Frank; Feenstra, Bjarke; Zhang, Hao

2011-01-01

The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years......, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at P...

Genome-Wide Association Study Identifies Four Loci Associated with Eruption of Permanent Teeth

Science.gov (United States)

Zhang, Hao; Shaffer, John R.; Hansen, Thomas; Esserlind, Ann-Louise; Boyd, Heather A.; Nohr, Ellen A.; Timpson, Nicholas J.; Fatemifar, Ghazaleh; Paternoster, Lavinia; Evans, David M.; Weyant, Robert J.; Levy, Steven M.; Lathrop, Mark; Smith, George Davey; Murray, Jeffrey C.; Olesen, Jes; Werge, Thomas; Marazita, Mary L.; Sørensen, Thorkild I. A.; Melbye, Mads

2011-01-01

The sequence and timing of permanent tooth eruption is thought to be highly heritable and can have important implications for the risk of malocclusion, crowding, and periodontal disease. We conducted a genome-wide association study of number of permanent teeth erupted between age 6 and 14 years, analyzed as age-adjusted standard deviation score averaged over multiple time points, based on childhood records for 5,104 women from the Danish National Birth Cohort. Four loci showed association at Peruption and were also known to influence height and breast cancer, respectively. The two other loci pointed to genomic regions without any previous significant genome-wide association study results. The intronic SNP rs7924176 in ADK could be linked to gene expression in monocytes. The combined effect of the four genetic variants was most pronounced between age 10 and 12 years, where children with 6 to 8 delayed tooth eruption alleles had on average 3.5 (95% confidence interval: 2.9–4.1) fewer permanent teeth than children with 0 or 1 of these alleles. PMID:21931568

Association studies in common endocrine diseases (review article

Directory of Open Access Journals (Sweden)

Akrami SM

2007-05-01

Full Text Available Our understanding of the pathogenesis of endocrine disorders increase rapidly by genetic studies at the molecular level. Common endocrine disorders such as diabetes mellitus, obesity, osteoporosis, dyslipidemia and cancer follow the multifactorial model in the genetic aspect. This review tries to clarify the approach in molecular studies of such diseases for clinicians in different specialties. How to evaluate a possible association between a single nucleotide polymorphism and an endocrinopathy or its complication is the main concern of this review. Two approaches for gene mapping will be discussed as well as main challenges regarding each approach. All such genetic studies ideally include some test of the association between genome sequence variation and the phenotype of interest such as the trait itself, the presence of a given complication, or measures of some endocrinopathy-related intermediate trait. Despite different advances in this analysis, there are major concerns regarding the overall performance and robustness of genetic association studies. By using powerful new high-throughput methods, further insights to molecular basis of such endocrine disorders can be expected. Close correlation between geneticists and clinicians can effectively bridge between basic sciences and clinical investigations.

The Hyena: Witch's Auxiliary or Nature's Fool?

OpenAIRE

Dunham, Margaret

2006-01-01

Le texte publié sera accompagné des enregistrements sonores et de l'analyse interlinéaire de deux contes mettant en scène des hyènes.; Although the hyena cannot be considered a 'keystone' animal in Valangi culture, through its associations with witchcraft, it nevertheless holds an important place in the collective imagination and in the traditional folklore.; Bien que l'hyène ne puisse pas être considérée comme animal 'clé de voûte' dans la culture Valangi, elle tient néanmoins une place impo...

Genome-wide association studies and resting heart rate

DEFF Research Database (Denmark)

Oskari Kilpeläinen, Tuomas

2016-01-01

Genome-wide association studies (GWASs) have revolutionized the search for genetic variants regulating resting heart rate. In the last 10 years, GWASs have led to the identification of at least 21 novel heart rate loci. These discoveries have provided valuable insights into the mechanisms...... and pathways that regulate heart rate and link heart rate to cardiovascular morbidity and mortality. GWASs capture majority of genetic variation in a population sample by utilizing high-throughput genotyping chips measuring genotypes for up to several millions of SNPs across the genome in thousands...... of individuals. This allows the identification of the strongest heart rate associated signals at genome-wide level. While GWASs provide robust statistical evidence of the association of a given genetic locus with heart rate, they are only the starting point for detailed follow-up studies to locate the causal...

Otnosno koncepta za češki nacionalen tanc: zašto i za kogo?

Czech Academy of Sciences Publication Activity Database

Stavělová, Daniela

2015-01-01

Roč. 41, č. 4 (2015), s. 467-490 ISSN 0323-9861 Institutional support: RVO:68378076 Keywords : dance * polka * national identity * etnicity * folklore Subject RIV: AC - Archeology, Anthropology, Ethnology

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study

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Niu Nifang

2012-09-01

Full Text Available Abstract Background Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs that might contribute to taxane response, we performed a genome-wide association study (GWAS for two taxanes, paclitaxel and docetaxel, using 276 lymphoblastoid cell lines (LCLs, followed by genotyping of top candidate SNPs in 874 lung cancer patient samples treated with paclitaxel. Methods GWAS was performed using 1.3 million SNPs and taxane cytotoxicity IC50 values for 276 LCLs. The association of selected SNPs with overall survival in 76 small or 798 non-small cell lung cancer (SCLC, NSCLC patients were analyzed by Cox regression model, followed by integrated SNP-microRNA-expression association analysis in LCLs and siRNA screening of candidate genes in SCLC (H196 and NSCLC (A549 cell lines. Results 147 and 180 SNPs were associated with paclitaxel or docetaxel IC50s with p-values -4 in the LCLs, respectively. Genotyping of 153 candidate SNPs in 874 lung cancer patient samples identified 8 SNPs (p-value PIP4K2A, CCT5, CMBL, EXO1, KMO and OPN3, genes within 200 kb up-/downstream of the 3 SNPs that were associated with SCLC overall survival (rs1778335, rs2662411 and rs7519667, significantly desensitized H196 to paclitaxel. SNPs rs2662411 and rs1778335 were associated with mRNA expression of CMBL or PIP4K2A through microRNA (miRNA hsa-miR-584 or hsa-miR-1468. Conclusions GWAS in an LCL model system, joined with clinical translational and functional studies, might help us identify genetic variations associated with overall survival of lung cancer patients treated paclitaxel.

Genome-wide association studies in asthma: progress and pitfalls

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March ME

2015-01-01

Full Text Available Michael E March,1 Patrick MA Sleiman,1,2 Hakon Hakonarson1,2 1Center for Applied Genomics, Children's Hospital of Philadelphia Research Institute, 2Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Abstract: Genetic studies of asthma have revealed that there is considerable heritability to the phenotype. An extensive history of candidate-gene studies has identified a long list of genes associated with immune function that are potentially involved in asthma pathogenesis. However, many of the results of candidate-gene studies have failed to be replicated, leaving in question the true impact of the implicated biological pathways on asthma. With the advent of genome-wide association studies, geneticists are able to examine the association of hundreds of thousands of genetic markers with a phenotype, allowing the hypothesis-free identification of variants associated with disease. Many such studies examining asthma or related phenotypes have been published, and several themes have begun to emerge regarding the biological pathways underpinning asthma. The results of many genome-wide association studies have currently not been replicated, and the large sample sizes required for this experimental strategy invoke difficulties with sample stratification and phenotypic heterogeneity. Recently, large collaborative groups of researchers have formed consortia focused on asthma, with the goals of sharing material and data and standardizing diagnosis and experimental methods. Additionally, research has begun to focus on genetic variants that affect the response to asthma medications and on the biology that generates the heterogeneity in the asthma phenotype. As this work progresses, it will move asthma patients closer to more specific, personalized medicine. Keywords: asthma, genetics, GWAS, pharmacogenetics, biomarkers

Genome-wide association study of clinical dimensions of schizophrenia

DEFF Research Database (Denmark)

Fanous, Ayman H; Zhou, Baiyu; Aggen, Steven H

2012-01-01

Multiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia.......Multiple sources of evidence suggest that genetic factors influence variation in clinical features of schizophrenia. The authors present the first genome-wide association study (GWAS) of dimensional symptom scores among individuals with schizophrenia....

Psychiatric disorders and obesity: A review of association studies

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T M Rajan

2017-01-01

Full Text Available Background: Inconsistent evidence exists regarding the strength, direction, and moderators in the relationship between obesity and psychiatric disorders. Aim: This study aims to summarize the evidence on the association between psychiatric illness and obesity with particular attention to the strength and direction of association and also the possible moderators in each postulated link. Materials and Methods: Systematic electronic searches of MEDLINE through PubMed, ScienceDirect, PsycINFO, and Google Scholar were carried out from inception till October 2016. Generated abstracts were screened for eligibility to be included in the review. Study designs that evaluated the strength of relationship between obesity and psychiatric disorders were included in the study. Quality assessment of included studies was done using the Newcastle–Ottawa checklist tool. Results: From a total of 2424 search results, 21 eligible articles were identified and reviewed. These included studies on obesity and depression (n = 15, obesity and anxiety (four and one each on obesity and personality disorders, eating disorder (ED, attention deficit hyperactivity disorder, and alcohol use. Maximal evidence existed for the association between depression and obesity with longitudinal studies demonstrating a bidirectional link between the two conditions. The odds ratios (ORs were similar for developing depression in obesity (OR: 1.21–5.8 and vice versa (OR: 1.18–3.76 with a stronger association observed in women. For anxiety disorders, evidence was mostly cross-sectional, and associations were of modest magnitude (OR: 1.27–1.40. Among other disorders, obesity, and EDs appear to have a close link (OR: 4.5. Alcohol use appears to be a risk factor for obesity and not vice versa but only among women (OR: 3.84. Conclusion: Obesity and depression have a significant and bidirectional association. Evidence is modest for anxiety disorders and inadequate for other psychiatric

Multivariate Meta-Analysis of Genetic Association Studies: A Simulation Study.

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Binod Neupane

Full Text Available In a meta-analysis with multiple end points of interests that are correlated between or within studies, multivariate approach to meta-analysis has a potential to produce more precise estimates of effects by exploiting the correlation structure between end points. However, under random-effects assumption the multivariate estimation is more complex (as it involves estimation of more parameters simultaneously than univariate estimation, and sometimes can produce unrealistic parameter estimates. Usefulness of multivariate approach to meta-analysis of the effects of a genetic variant on two or more correlated traits is not well understood in the area of genetic association studies. In such studies, genetic variants are expected to roughly maintain Hardy-Weinberg equilibrium within studies, and also their effects on complex traits are generally very small to modest and could be heterogeneous across studies for genuine reasons. We carried out extensive simulation to explore the comparative performance of multivariate approach with most commonly used univariate inverse-variance weighted approach under random-effects assumption in various realistic meta-analytic scenarios of genetic association studies of correlated end points. We evaluated the performance with respect to relative mean bias percentage, and root mean square error (RMSE of the estimate and coverage probability of corresponding 95% confidence interval of the effect for each end point. Our simulation results suggest that multivariate approach performs similarly or better than univariate method when correlations between end points within or between studies are at least moderate and between-study variation is similar or larger than average within-study variation for meta-analyses of 10 or more genetic studies. Multivariate approach produces estimates with smaller bias and RMSE especially for the end point that has randomly or informatively missing summary data in some individual studies, when

Evidence-based systematic review of saw palmetto by the Natural Standard Research Collaboration.

Science.gov (United States)

Ulbricht, Catherine; Basch, Ethan; Bent, Steve; Boon, Heather; Corrado, Michelle; Foppa, Ivo; Hashmi, Sadaf; Hammerness, Paul; Kingsbury, Eileen; Smith, Michael; Szapary, Philippe; Vora, Mamta; Weissner, Wendy

2006-01-01

Here presented is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.

Ishmael Reed and the Politics of Aesthetics, or Shake Hands and Come Out Conjuring

Science.gov (United States)

Fontenot, Chester J.

1978-01-01

Discusses the ways in which Ishmael Reed uses black American folklore, black American language, traditional African religion, and African myths as poetic materials from which he develops artistic forms. (GW)

Filtrirane na narodnoto. Narodna muzika i ideologija v Čechoslovakija prez petdesette godini na XX vek

Czech Academy of Sciences Publication Activity Database

Kratochvíl, Matěj

2015-01-01

Roč. 41, č. 4 (2015), s. 513-522 ISSN 0323-9861 Institutional support: RVO:68378076 Keywords : folklore * folk music * communism * Czechoslovakia * national identity Subject RIV: AC - Archeology, Anthropology, Ethnology

Erotikata v češkite narodni prikazki i anekdoti

Czech Academy of Sciences Publication Activity Database

Otčenášek, Jaroslav

2015-01-01

Roč. 41, č. 4 (2015), s. 448-466 ISSN 0323-9861 Institutional support: RVO:68378076 Keywords : erotica * sexuality * vulgarism * czech folklore * tale * anecdote Subject RIV: AC - Archeology, Anthropology, Ethnology

Vymyslet festival: čtvrtstoletí Folklorního festivalu Pardubice - Hradec Králové

Czech Academy of Sciences Publication Activity Database

Stavělová, Daniela

2016-01-01

Roč. 26, č. 4 (2016), s. 352-355 ISSN 0862-8351 Institutional support: RVO:68378076 Keywords : festival * stage * folklore * dance * music * Czech Republic Subject RIV: AC - Archeology, Anthropology, Ethnology

Několik poznámek k masopustní slavnosti Bakchus v českých zemích

Czech Academy of Sciences Publication Activity Database

Altman, Karel

2015-01-01

Roč. 49, č. 1 (2015), s. 63-73 ISSN 0862-1209 Institutional support: RVO:68378076 Keywords : carnival * Czech Lands * Bakchus * folklore * yearly customs Subject RIV: AC - Archeology, Anthropology, Ethnology

Genome-Wide Association Studies of the Human Gut Microbiota.

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Emily R Davenport

Full Text Available The bacterial composition of the human fecal microbiome is influenced by many lifestyle factors, notably diet. It is less clear, however, what role host genetics plays in dictating the composition of bacteria living in the gut. In this study, we examined the association of ~200K host genotypes with the relative abundance of fecal bacterial taxa in a founder population, the Hutterites, during two seasons (n = 91 summer, n = 93 winter, n = 57 individuals collected in both. These individuals live and eat communally, minimizing variation due to environmental exposures, including diet, which could potentially mask small genetic effects. Using a GWAS approach that takes into account the relatedness between subjects, we identified at least 8 bacterial taxa whose abundances were associated with single nucleotide polymorphisms in the host genome in each season (at genome-wide FDR of 20%. For example, we identified an association between a taxon known to affect obesity (genus Akkermansia and a variant near PLD1, a gene previously associated with body mass index. Moreover, we replicate a previously reported association from a quantitative trait locus (QTL mapping study of fecal microbiome abundance in mice (genus Lactococcus, rs3747113, P = 3.13 x 10-7. Finally, based on the significance distribution of the associated microbiome QTLs in our study with respect to chromatin accessibility profiles, we identified tissues in which host genetic variation may be acting to influence bacterial abundance in the gut.

Associative visual agnosia: a case study.

Science.gov (United States)

Charnallet, A; Carbonnel, S; David, D; Moreaud, O

2008-01-01

We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study, an alternative account in the framework of (non abstractive) episodic models of memory.

Del mito de “la silla peligrosa” a la leyenda urbana de la aguja escondida y el contagio del SIDA

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Ángel J. Gonzalo Tobajas

2014-11-01

Full Text Available Although urban legends are considered of modern folklore paradigms, its origins can be traced to different cultures and different times. This article begins with different versions of a rumor that was spread through the internet and warned about possible AIDS infections by hidden needles in movie theater seats; and concludes by showing that this is a common motif in world literature syllabus: the Greek mythology offered us the versions of Theseus and Pirithous trapped in the Hades or the Procrustean bed, and the arthurian literature the “Siége Perilous” of Galaz, for example. Furthermore, folklores as different as the Mayan of Yucatan or the Spanish of the village of Luciana (Ciudad Real give due consideration to this topic.

MACUNAÍMA, O HERÓI SEM NENHUM CARÁTER

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Prof. Ms. Maria Teresa Hellmeister Fornaciari

2011-05-01

Full Text Available According to an unpublished preface, Mário de Andrade himself said that Macunaíma is an anthology of Brazilian folklore. This text aims to analyse some aspects of this folklore throughout the pages of the work seen as one of the major pillars of Brazilian literature. In addition, the fiction not only mirrors what the Brazilian man was, what he is and what he will be (? but focalizes the Brazilian writer, his deep and indispensable roots so that he can be born and flourish with resourcefulness and talent as well. This text also aims to highlight the importance on using these genuine values on art compositions as it was accomplished in the remarkable text of Mário de Andrade.

Genome-wide association study of antisocial personality disorder.

Science.gov (United States)

Rautiainen, M-R; Paunio, T; Repo-Tiihonen, E; Virkkunen, M; Ollila, H M; Sulkava, S; Jolanki, O; Palotie, A; Tiihonen, J

2016-09-06

The pathophysiology of antisocial personality disorder (ASPD) remains unclear. Although the most consistent biological finding is reduced grey matter volume in the frontal cortex, about 50% of the total liability to developing ASPD has been attributed to genetic factors. The contributing genes remain largely unknown. Therefore, we sought to study the genetic background of ASPD. We conducted a genome-wide association study (GWAS) and a replication analysis of Finnish criminal offenders fulfilling DSM-IV criteria for ASPD (N=370, N=5850 for controls, GWAS; N=173, N=3766 for controls and replication sample). The GWAS resulted in suggestive associations of two clusters of single-nucleotide polymorphisms at 6p21.2 and at 6p21.32 at the human leukocyte antigen (HLA) region. Imputation of HLA alleles revealed an independent association with DRB1*01:01 (odds ratio (OR)=2.19 (1.53-3.14), P=1.9 × 10(-5)). Two polymorphisms at 6p21.2 LINC00951-LRFN2 gene region were replicated in a separate data set, and rs4714329 reached genome-wide significance (OR=1.59 (1.37-1.85), P=1.6 × 10(-9)) in the meta-analysis. The risk allele also associated with antisocial features in the general population conditioned for severe problems in childhood family (β=0.68, P=0.012). Functional analysis in brain tissue in open access GTEx and Braineac databases revealed eQTL associations of rs4714329 with LINC00951 and LRFN2 in cerebellum. In humans, LINC00951 and LRFN2 are both expressed in the brain, especially in the frontal cortex, which is intriguing considering the role of the frontal cortex in behavior and the neuroanatomical findings of reduced gray matter volume in ASPD. To our knowledge, this is the first study showing genome-wide significant and replicable findings on genetic variants associated with any personality disorder.

Genome-wide association study of antisocial personality disorder

Science.gov (United States)

Rautiainen, M-R; Paunio, T; Repo-Tiihonen, E; Virkkunen, M; Ollila, H M; Sulkava, S; Jolanki, O; Palotie, A; Tiihonen, J

2016-01-01

The pathophysiology of antisocial personality disorder (ASPD) remains unclear. Although the most consistent biological finding is reduced grey matter volume in the frontal cortex, about 50% of the total liability to developing ASPD has been attributed to genetic factors. The contributing genes remain largely unknown. Therefore, we sought to study the genetic background of ASPD. We conducted a genome-wide association study (GWAS) and a replication analysis of Finnish criminal offenders fulfilling DSM-IV criteria for ASPD (N=370, N=5850 for controls, GWAS; N=173, N=3766 for controls and replication sample). The GWAS resulted in suggestive associations of two clusters of single-nucleotide polymorphisms at 6p21.2 and at 6p21.32 at the human leukocyte antigen (HLA) region. Imputation of HLA alleles revealed an independent association with DRB1*01:01 (odds ratio (OR)=2.19 (1.53–3.14), P=1.9 × 10-5). Two polymorphisms at 6p21.2 LINC00951–LRFN2 gene region were replicated in a separate data set, and rs4714329 reached genome-wide significance (OR=1.59 (1.37–1.85), P=1.6 × 10−9) in the meta-analysis. The risk allele also associated with antisocial features in the general population conditioned for severe problems in childhood family (β=0.68, P=0.012). Functional analysis in brain tissue in open access GTEx and Braineac databases revealed eQTL associations of rs4714329 with LINC00951 and LRFN2 in cerebellum. In humans, LINC00951 and LRFN2 are both expressed in the brain, especially in the frontal cortex, which is intriguing considering the role of the frontal cortex in behavior and the neuroanatomical findings of reduced gray matter volume in ASPD. To our knowledge, this is the first study showing genome-wide significant and replicable findings on genetic variants associated with any personality disorder. PMID:27598967

Bayesian graphical models for genomewide association studies.

Science.gov (United States)

Verzilli, Claudio J; Stallard, Nigel; Whittaker, John C

2006-07-01

As the extent of human genetic variation becomes more fully characterized, the research community is faced with the challenging task of using this information to dissect the heritable components of complex traits. Genomewide association studies offer great promise in this respect, but their analysis poses formidable difficulties. In this article, we describe a computationally efficient approach to mining genotype-phenotype associations that scales to the size of the data sets currently being collected in such studies. We use discrete graphical models as a data-mining tool, searching for single- or multilocus patterns of association around a causative site. The approach is fully Bayesian, allowing us to incorporate prior knowledge on the spatial dependencies around each marker due to linkage disequilibrium, which reduces considerably the number of possible graphical structures. A Markov chain-Monte Carlo scheme is developed that yields samples from the posterior distribution of graphs conditional on the data from which probabilistic statements about the strength of any genotype-phenotype association can be made. Using data simulated under scenarios that vary in marker density, genotype relative risk of a causative allele, and mode of inheritance, we show that the proposed approach has better localization properties and leads to lower false-positive rates than do single-locus analyses. Finally, we present an application of our method to a quasi-synthetic data set in which data from the CYP2D6 region are embedded within simulated data on 100K single-nucleotide polymorphisms. Analysis is quick (<5 min), and we are able to localize the causative site to a very short interval.

Theory of Tatar Origin of the Yakuts

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V.V. Ushnitsky

2014-01-01

Full Text Available The article examines the problem of the origin of the people of Sakha (Yakutia in the light of the latest research. Basing on archaeological materials the ethnogenesis of Sakha is associated with the Baikal region’s Ust’-Tal’kinsky archaeological culture of the 12th–14th centuries. Analysis of written sources allows to associate representatives of Ust’-Tal’kinsky archaeological culture with the Usutu-mangun tribe identical with the Angara Tatars and referred to in the writings of Rashid al-Din and Abu al-Ghazi. Probably, the Angara Tatars migrated from Central Asia and compactly inhabited the Angara region near Lake Buir-Nur. The article analyzes connection between Sakha folklore sources and real history of Central Asian Tatars.

Microbiome-wide association studies link dynamic microbial consortia to disease

Energy Technology Data Exchange (ETDEWEB)

Gilbert, Jack A.; Quinn, Robert A.; Debelius, Justine; Xu, Zhenjiang Z.; Morton, James; Garg, Neha; Jansson, Janet K.; Dorrestein, Pieter C.; Knight, Rob

2016-07-06

Rapid advances in DNA sequencing, metabolomics, proteomics and computational tools are dramatically increasing access to the microbiome and identification of its links with disease. In particular, time-series studies and multiple molecular perspectives are facilitating microbiome-wide association studies, which are analogous to genome-wide association studies. Early findings point to actionable outcomes of microbiome-wide association studies, although their clinical application has yet to be approved. An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies that are based on the microbiome.

Folkloor ja massikultuur / Rudolf Schenda ; tõlkinud Kalle Voolaid

Index Scriptorium Estoniae

Schenda, Rudolf, 1930-

1994-01-01

Originaalartikkel ilmunud kogumikus Tradition and Modernisation : Planary papers read at the 4th International Congress of the Société Internationale d'Ethnologie de Folklore. Turku, 1992, lk. 23-28

Understanding Salesforce Behavior using Genetic Association Studies

NARCIS (Netherlands)

W.E. van den Berg (Wouter)

2014-01-01

markdownabstract__Abstract__ Using genetic association studies, this thesis aims to investigate the drivers of successful customer-salesperson interactions in a context where knowledge development has become crucial to the value creation process. Central to this thesis is the developing role of

Associative Visual Agnosia: A Case Study

Directory of Open Access Journals (Sweden)

A. Charnallet

2008-01-01

Full Text Available We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study [1], an alternative account in the framework of (non abstractive episodic models of memory [4].

Associative Visual Agnosia: A Case Study

OpenAIRE

Charnallet, A.; Carbonnel, S.; David, D.; Moreaud, O.

2008-01-01

We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study [1], an alternative account in the framework of (non abstractive) episodic models of memory [4].

Multiculturalism: Beyond Food, Festival, Folklore, and Fashion

Science.gov (United States)

Meyer, Calvin F.; Rhoades, Elizabeth Kelley

2006-01-01

Despite overall trends toward increasing student diversity, geographic areas in the United States vary widely in their ethnic composition. In areas where the population is predominately European American, grasping a realistic meaning of "multiculturalism" can be difficult. Often, interpretations of the concept result in a mix of…

AHP 10: Folklore: Bear and Rabbit (I

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G.yu lha གཡུ་ལྷ།

2011-06-01

Full Text Available G.yu Iha writes: I recorded this folktale from Thub bstan (b. 1936, the reincarnate lama in Siyuewu Village (Puxi Township, Rangtang County, Aba Tibetan and Qiang Autonomous Prefecture, Sichuan Province when I visited him in the winter of 2009-2010. Thub bstan learned this folktale from his mother. I heard this tale when I was around six years old from my great grandfather when my family was having dinner near the stove one evening.

Genome-wide association studies (GWAS) of adiposity

DEFF Research Database (Denmark)

Oskari Kilpeläinen, Tuomas; Ingelsson, Erik

2016-01-01

Adiposity is strongly heritable and one of the leading risk factors for type 2 diabetes, cardiovascular disease, cancer, and premature death. In the past 8 years, genome-wide association studies (GWAS) have greatly increased our understanding of the genes and biological pathways that regulate...

Gastroschisis and associated defects: an international study.

LENUS (Irish Health Repository)

Mastroiacovo, Pierpaolo

2007-04-01

Our objective was to evaluate the frequency and type of malformations associated with gastroschisis in a large pool of international data, to identify malformation patterns, and to evaluate the role of maternal age in non-isolated cases. Case-by-case information from 24 registries, all members of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), were evaluated. After the exclusion of other abdominal wall defects cases were classified as: (a) isolated; (b) recognizable syndrome, chromosomal or not; (c) multiple congenital anomalies (MCA). Our results showed that out of 3,322 total cases 469 non-isolated cases were registered (14.1%): 41 chromosomal syndromes, 24 other syndromes, and 404 MCA. Among MCA four groups of anomalies were most frequent: CNS (4.5%), cardio-vascular (2.5%), limb (2.2%), and kidney anomalies (1.9%). No similar patterns emerged except two patterns resembling limb-body wall complex and OEIS. In both of them the gastroschisis could be however misclassified. Chromosomal trisomies and possibly non-syndromic MCA are associated with an older maternal age more than isolated cases. On consideration of our data and the most valid studies published in the literature, the best estimate of the proportion of gastroschisis associated with major unrelated defects is about 10%, with a few cases associated to recognizable syndromes. Recognized syndromes with gastroschisis seem to be so exceptional that the well documented and validated cases are worth being published as interesting case report. An appropriate case definition in etiological studies should include only isolated gastroschisis after an appropriate definition of isolated and non-isolated cases and a thorough case-by-case review.

A Genome-Wide Association Study Primer for Clinicians

Directory of Open Access Journals (Sweden)

Tzu-Hao Wang

2009-06-01

Full Text Available Genome-wide association studies (GWAS use high-throughput genotyping technology to relate hundreds of thousands of genetic markers (genotypes to clinical conditions and measurable traits (phenotypes. This review is intended to serve as an introduction to GWAS for clinicians, to allow them to better appreciate the value and limitations of GWAS for genotype-disease association studies. The input of clinicians is vital for GWAS, since disease heterogeneity is frequently a confounding factor that can only really be solved by clinicians. For diseases that are difficult to diagnose, clinicians should ensure that the cases do indeed have the disease; for common diseases, clinicians should ensure that the controls are truly disease-free.

Plaadid / Andri Maimets

Index Scriptorium Estoniae

Maimets, Andri, 1979-

2004-01-01

Uutest plaatidest Nelly Furtado "Folklore", Asian Dub Foundation "Keep Bangin' On The Walls", Blondie "The Curse Of...", David Benoit "Right Here Right Now", Yello "The Eye", Missy Elliott "This Is Not A Test"

Posměšky a přezdívky jako součást komunikace dětí a mládeže

Czech Academy of Sciences Publication Activity Database

Pospíšilová, Jana; Altman, Karel

2010-01-01

Roč. 17, 1-2 (2010), s. 108-116 ISSN 1335-5074 Institutional research plan: CEZ:AV0Z90580513 Keywords : ethnology * children's folklore * communication * nicknames * tramping Subject RIV: AC - Archeology, Anthropology, Ethnology

Type 1 diabetes genome-wide association studies

DEFF Research Database (Denmark)

Pociot, Flemming

2017-01-01

Genetic studies have identified >60 loci associated with the risk of developing type 1 diabetes (T1D). The vast majority of these are identified by genome-wide association studies (GWAS) using large case-control cohorts of European ancestry. More than 80% of the heritability of T1D can be explained...... by GWAS data in this population group. However, with few exceptions, their individual contribution to T1D risk is low and understanding their function in disease biology remains a huge challenge. GWAS on its own does not inform us in detail on disease mechanisms, but the combination of GWAS data...... with other omics-data is beginning to advance our understanding of T1D etiology and pathogenesis. Current knowledge supports the notion that genetic variation in both pancreatic β cells and in immune cells is central in mediating T1D risk. Advances, perspectives and limitations of GWAS are discussed...

Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal.

Science.gov (United States)

Delgado, Dayana A; Zhang, Chenan; Chen, Lin S; Gao, Jianjun; Roy, Shantanu; Shinkle, Justin; Sabarinathan, Mekala; Argos, Maria; Tong, Lin; Ahmed, Alauddin; Islam, Tariqul; Rakibuz-Zaman, Muhammad; Sarwar, Golam; Shahriar, Hasan; Rahman, Mahfuzar; Yunus, Mohammad; Jasmine, Farzana; Kibriya, Muhammad G; Ahsan, Habibul; Pierce, Brandon L

2018-01-01

Leucocyte telomere length (TL) is a potential biomarker of ageing and risk for age-related disease. Leucocyte TL is heritable and shows substantial differences by race/ethnicity. Recent genome-wide association studies (GWAS) report ~10 loci harbouring SNPs associated with leucocyte TL, but these studies focus primarily on populations of European ancestry. This study aims to enhance our understanding of genetic determinants of TL across populations. We performed a GWAS of TL using data on 5075 Bangladeshi adults. We measured TL using one of two technologies (qPCR or a Luminex-based method) and used standardised variables as TL phenotypes. Our results replicate previously reported associations in the TERC and TERT regions (P=2.2×10 -8 and P=6.4×10 -6 , respectively). We observed a novel association signal in the RTEL1 gene (intronic SNP rs2297439; P=2.82×10 -7 ) that is independent of previously reported TL-associated SNPs in this region. The minor allele for rs2297439 is common in South Asian populations (≥0.25) but at lower frequencies in other populations (eg, 0.07 in Northern Europeans). Among the eight other previously reported association signals, all were directionally consistent with our study, but only rs8105767 ( ZNF208 ) was nominally significant (P=0.003). SNP-based heritability estimates were as high as 44% when analysing close relatives but much lower when analysing distant relatives only. In this first GWAS of TL in a South Asian population, we replicate some, but not all, of the loci reported in prior GWAS of individuals of European ancestry, and we identify a novel second association signal at the RTEL1 locus. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Imputation-based analysis of association studies: candidate regions and quantitative traits.

Directory of Open Access Journals (Sweden)

Bertrand Servin

2007-07-01

Full Text Available We introduce a new framework for the analysis of association studies, designed to allow untyped variants to be more effectively and directly tested for association with a phenotype. The idea is to combine knowledge on patterns of correlation among SNPs (e.g., from the International HapMap project or resequencing data in a candidate region of interest with genotype data at tag SNPs collected on a phenotyped study sample, to estimate ("impute" unmeasured genotypes, and then assess association between the phenotype and these estimated genotypes. Compared with standard single-SNP tests, this approach results in increased power to detect association, even in cases in which the causal variant is typed, with the greatest gain occurring when multiple causal variants are present. It also provides more interpretable explanations for observed associations, including assessing, for each SNP, the strength of the evidence that it (rather than another correlated SNP is causal. Although we focus on association studies with quantitative phenotype and a relatively restricted region (e.g., a candidate gene, the framework is applicable and computationally practical for whole genome association studies. Methods described here are implemented in a software package, Bim-Bam, available from the Stephens Lab website http://stephenslab.uchicago.edu/software.html.

Recommendations for using standardised phenotypes in genetic association studies

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Naylor Melissa G

2009-07-01

Full Text Available Abstract Genetic association studies of complex traits often rely on standardised quantitative phenotypes, such as percentage of predicted forced expiratory volume and body mass index to measure an underlying trait of interest (eg lung function, obesity. These phenotypes are appealing because they provide an easy mechanism for comparing subjects, although such standardisations may not be the best way to control for confounders and other covariates. We recommend adjusting raw or standardised phenotypes within the study population via regression. We illustrate through simulation that optimal power in both population- and family-based association tests is attained by using the residuals from within-study adjustment as the complex trait phenotype. An application of family-based association analysis of forced expiratory volume in one second, and obesity in the Childhood Asthma Management Program data, illustrates that power is maintained or increased when adjusted phenotype residuals are used instead of typical standardised quantitative phenotypes.

Exome-wide association study of endometrial cancer in a multiethnic population.

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Maxine M Chen

Full Text Available Endometrial cancer (EC contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. Three previous genome-wide association studies (GWAS have found only one locus associated with EC, suggesting that common variants with large effects may not contribute greatly to EC risk. Alternatively, we hypothesize that rare variants may contribute to EC risk. We conducted an exome-wide association study (EXWAS of EC using the Infinium HumanExome BeadChip in order to identify rare variants associated with EC risk. We successfully genotyped 177,139 variants in a multiethnic population of 1,055 cases and 1,778 controls from four studies that were part of the Epidemiology of Endometrial Cancer Consortium (E2C2. No variants reached global significance in the study, suggesting that more power is needed to detect modest associations between rare genetic variants and risk of EC.

Child health, nutrition and family size: a comparative study of rural and urban children.

Science.gov (United States)

Balderama-guzman, V

1978-01-01

771 children from Baras, Rizal, and Pasay City, Philippines were studied. House interviews of mothers using precoded questionnaires were conducted and the children were given a complete physical examination. The study objectives were to compare the health and nutritional status of children in a rural and an urban area in greater Manila and to determine how family size affects the nutritional status of children 3 years and younger. The following were among the study results: 1) the weight curves of both urban and rural groups were similar until age 4-1/2 years, but beyond this age the mean weight curve of the rural group exceeded that of the urban group; 2) urban children between ages 1-5 enjoyed a height advantage; 3) there was a positive correlation between malnutrition and excessive family size; 4) the high prevalence of malnutrition among children 1-4 years of age was due to food deprivation because of poverty, parental ignorance, inappropriate folklores, oversized families, high episodes of illnesses, and inadequate medical care; and 5) dietary assessment of both groups showed the inadequacy of the quality and quantity of basic nutrients and elements needed for growth, development, and repair of tissues.

A study of antidiabetic and antioxidant effects of Helichrysum graveolens capitulums in streptozotocin-induced diabetic rats.

Science.gov (United States)

Aslan, Mustafa; Orhan, Didem Deliorman; Orhan, Nilüfer; Sezik, Ekrem; Yeşilada, Erdem

2007-06-01

Helichrysum graveolens (Bieb.) Sweet (Asteraceae) grows widely in Turkey. Capitulums of H. graveolens are used in the treatment of many diseases such as jaundice and wound healing and as a diuretic in the rural areas of Anatolia. The decoction from the capitulums of the plant is consumed for the symptoms of diabetes mellitus in folk medicine. In the present study, the hypoglycemic, antihyperglycemic, and antioxidant potentials of water and ethanol extracts of H. graveolens were evaluated by using in vivo methods in normal and streptozotocin-induced diabetic rats. Blood glucose levels of animals were measured by the glucose oxidase method. The antioxidant activity of these extracts was also studied in liver, kidney, and heart tissues. In order to determine antioxidant activity, tissue malondialdehyde and reduced glutathione levels were measured by using spectrophotometric methods. The experimental data obtained from water and ethanol extracts of capitulums confirmed the folkloric utilization. In order to discuss the role of polyphenolic components in the relevant activity, total phenol and flavonoid contents of each extract were also determined using the Folin-Ciocalteu reagent, and a positive correlation was observed.

The Interethnic and Interreligious Values in Turkish and Crimean Legends

OpenAIRE

Anastasiia Zherdieva

2014-01-01

The present paper examines interethnic and interreligious values in Turkish and Crimean folk legends. The folklore of both Crimea and Turkey has a multicultural background, which makes both corpuses of texts suitable for research. In the course of the study, a wide range of published Turkish and Crimean legends were reviewed and analysed. There are two deeply-rooted tendencies in the studied legends. First of all, the interethnic and interreligious relationships can be described as ghastly an...

Sincipital Encephaloceles: A Study of Associated Brain Malformations

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Shashidhar Vedavyas Achar

2016-01-01

Full Text Available Objective: The aim of this study was to evaluate the associated intracranial malformations in patients with sincipital encephaloceles. Materials and Methods: A hospital-based cross-sectional study was conducted over 8 years from June 2007 to May 2015 on 28 patients. The patients were evaluated by either computed tomography or magnetic resonance imaging whichever was feasible. Encephaloceles were described with respect to their types, contents, and extensions. A note was made on the associated malformations with sincipital encephaloceles. Results: Fifty percent of the patients presented before the age of 3 years and both the sexes were affected equally. Nasofrontal encephalocele was the most common type seen in 13 patients (46.4%, and corpus callosal agenesis (12 patients was the most common associated malformation. Other malformations noted were arachnoid cyst (10 patients, hydrocephalus (7 patients, and agyria-pachygyria complex (2 patients. Conclusion: Capital Brain malformations are frequently encountered in children with sincipital encephaloceles. Detail radiological evaluation is necessary to plan treatment and also to prognosticate such rare malformations.

Gene set-based analysis of polymorphisms: finding pathways or biological processes associated to traits in genome-wide association studies

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Medina, Ignacio; Montaner, David; Bonifaci, Nuria; Pujana, Miguel Angel; Carbonell, José; Tarraga, Joaquin; Al-Shahrour, Fatima; Dopazo, Joaquin

2009-01-01

Genome-wide association studies have become a popular strategy to find associations of genes to traits of interest. Despite the high-resolution available today to carry out genotyping studies, the success of its application in real studies has been limited by the testing strategy used. As an alternative to brute force solutions involving the use of very large cohorts, we propose the use of the Gene Set Analysis (GSA), a different analysis strategy based on testing the association of modules of functionally related genes. We show here how the Gene Set-based Analysis of Polymorphisms (GeSBAP), which is a simple implementation of the GSA strategy for the analysis of genome-wide association studies, provides a significant increase in the power testing for this type of studies. GeSBAP is freely available at http://bioinfo.cipf.es/gesbap/ PMID:19502494

Genome-wide association studies in Alzheimer's disease.

Science.gov (United States)

Bertram, Lars; Tanzi, Rudolph E

2009-10-15

Genome-wide association studies (GWAS) have gained considerable momentum over the last couple of years for the identification of novel complex disease genes. In the field of Alzheimer's disease (AD), there are currently eight published and two provisionally reported GWAS, highlighting over two dozen novel potential susceptibility loci beyond the well-established APOE association. On the basis of the data available at the time of this writing, the most compelling novel GWAS signal has been observed in GAB2 (GRB2-associated binding protein 2), followed by less consistently replicated signals in galanin-like peptide (GALP), piggyBac transposable element derived 1 (PGBD1), tyrosine kinase, non-receptor 1 (TNK1). Furthermore, consistent replication has been recently announced for CLU (clusterin, also known as apolipoprotein J). Finally, there are at least three replicated loci in hitherto uncharacterized genomic intervals on chromosomes 14q32.13, 14q31.2 and 6q24.1 likely implicating the existence of novel AD genes in these regions. In this review, we will discuss the characteristics and potential relevance to pathogenesis of the outcomes of all currently available GWAS in AD. A particular emphasis will be laid on findings with independent data in favor of the original association.

Phytopharmacological and ethnomedicinal uses of the Genus Berberis

African Journals Online (AJOL)

Plants belonging to Berberis are reported in several folklore medicinal ... Their antibacterial, antifungal, antiviral, anti-diabetic, and anti-tumor activities as well as ... The present review focuses on recent advances in phytopharmacological and ...

Phytochemical analysis and anti-oxidant activities of Albuca bracteata Jacq. and Albuca setosa Jacq bulb extracts used for the management of diabetes in the Eastern Cape, South Africa

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Samuel Odeyemi

2017-06-01

Conclusion: This implies that the bulb of Albuca bracteata may serve as a natural source of antioxidants, which together with the numerous phytochemicals present, could account for its folkloric use as a medicinal plant.

The Fairy-Folk Tale in Media Art: Reflections of Disney and Duvall.

Science.gov (United States)

Molloy, Toni

1988-01-01

Focuses on Walt Disney and Shelley Duvall, mass media producers who furnish children with fairy-folklore. Compares and contrasts what Disney and Duvall do and do not convey through their fairy-folk tales. (MS)

Ot ritualnite žertvi kăm răčenicata v minižupi (Etnomuzikovedski impresii ot Bălgarija)

Czech Academy of Sciences Publication Activity Database

Tyllner, Lubomír

2015-01-01

Roč. 41, č. 4 (2015), s. 523-536 ISSN 0323-9861 Institutional support: RVO:68378076 Keywords : ethnomusicology * bulgarian folklore tradition * folk dance * traditional music * music al instruments Subject RIV: AC - Archeology, Anthropology, Ethnology

Česká lidová slovesnost a internet: Humor v e-mailech

Czech Academy of Sciences Publication Activity Database

Otčenášek, Jaroslav

2007-01-01

Roč. 94, č. 4 (2007), s. 363-375 ISSN 0009-0794 Institutional research plan: CEZ:AV0Z90580513 Keywords : oral folklore * new media * internet * parody * anecdote Subject RIV: AC - Archeology, Anthropology, Ethnology

TOWARDS A GLOBAL 2l5 T CENTURY AFRICAN POPULAR MUSIC

African Journals Online (AJOL)

implications of this development for African music and musicians, with a ... carried not only men, women and children, but also their gods, beliefs and folklore". Considering the ... "population movements that followed territorial expansion, wars,.

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.

Science.gov (United States)

Erzurumluoglu, A Mesut; Baird, Denis; Richardson, Tom G; Timpson, Nicholas J; Rodriguez, Santiago

2018-01-22

Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. Therefore, hidden stratification and/or differential phenotypic effects by Y-DNA haplogroups could exist. To test this, we hypothesised that stratifying individuals according to their Y-DNA haplogroups before testing for associations between autosomal single nucleotide polymorphisms (SNPs) and phenotypes will yield difference in association. For proof of concept, we derived Y-DNA haplogroups from 6537 males from two epidemiological cohorts, Avon Longitudinal Study of Parents and Children (ALSPAC) ( n = 5080; 816 Y-DNA SNPs) and the 1958 Birth Cohort ( n = 1457; 1849 Y-DNA SNPs), and studied the robust associations between 32 SNPs and body mass index (BMI), including SNPs in or near Fat Mass and Obesity-associated protein ( FTO ) which yield the strongest effects. Overall, no association was replicated in both cohorts when Y-DNA haplogroups were considered and this suggests that, for BMI at least, there is little evidence of differences in phenotype or SNP association by Y-DNA structure. Further studies using other traits, phenome-wide association studies (PheWAS), other haplogroups and/or autosomal SNPs are required to test the generalisability and utility of this approach.

Prospective study of blood metabolites associated with colorectal cancer risk.

Science.gov (United States)

Shu, Xiang; Xiang, Yong-Bing; Rothman, Nathaniel; Yu, Danxia; Li, Hong-Lan; Yang, Gong; Cai, Hui; Ma, Xiao; Lan, Qing; Gao, Yu-Tang; Jia, Wei; Shu, Xiao-Ou; Zheng, Wei

2018-02-26

Few prospective studies, and none in Asians, have systematically evaluated the relationship between blood metabolites and colorectal cancer risk. We conducted a nested case-control study to search for risk-associated metabolite biomarkers for colorectal cancer in an Asian population using blood samples collected prior to cancer diagnosis. Conditional logistic regression was performed to assess associations of metabolites with cancer risk. In this study, we included 250 incident cases with colorectal cancer and individually matched controls nested within two prospective Shanghai cohorts. We found 35 metabolites associated with risk of colorectal cancer after adjusting for multiple comparisons. Among them, 12 metabolites were glycerophospholipids including nine associated with reduced risk of colorectal cancer and three with increased risk [odds ratios per standard deviation increase of transformed metabolites: 0.31-1.98; p values: 0.002-1.25 × 10 -10 ]. The other 23 metabolites associated with colorectal cancer risk included nine lipids other than glycerophospholipid, seven aromatic compounds, five organic acids and four other organic compounds. After mutual adjustment, nine metabolites remained statistically significant for colorectal cancer. Together, these independently associated metabolites can separate cancer cases from controls with an area under the curve of 0.76 for colorectal cancer. We have identified that dysregulation of glycerophospholipids may contribute to risk of colorectal cancer. © 2018 UICC.

FORGOTTEN PAGES FROM ION MACOVEI’S CREATION

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COCEAROVA GALINA

2015-09-01

Full Text Available This article is devoted to Ion Macovei’s creation, namely, to his Symphonieta Florile dalbe (lily-whiteflowers in the ver­sion for string orchestra, realized by conductor Dumitru Goia. The author presents some information about the history of this creation and analyses the six-part cycle of the Symphonieta, where every movement has its own title in Latin. The character of these miniatures which are closely connected with Moldova calendar folklore, and first of all, with the carol genre, deter­mined the use of both archetypes of the monodic melody and of the early heterophony principles as well as the mode systems characteristic of regional musical folklore. here is also an analysis of the methods of orchestration used by Dumitru Goia in the score of the Symphonieta.

Implications of rural tourism and agritourism in sustainable rural development

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Flavia-Lorena Cut-Lupulescu

2014-10-01

Full Text Available Romania shows: a variety of historical cultural values ​​- folk art, ethnography, folklore, traditions, historical artifacts - a natural harmoniously combined with a varied and picturesque landscape background. All these are facets of Romanian rural tourism in particular. Occurred and developed by the various forms of relief since the time of the Thracian-Dacian, Romanian rural settlements kept and still keeps in good measure ancient customs and traditions, a rich and varied folklore, ethnography and folk original elements that can be travel exploited in a strategy for the organization and development of rural tourism. Rural tourism in our country always practical, but spontaneous, sporadic, random, and mostly unorganized form of manifestation is the beginning of the '20s and '30s, the casual visitor accommodation citizens of rural settlements.

Eta-expansion does The Trick

DEFF Research Database (Denmark)

Danvy, Olivier; Malmkjær, Karoline; Palsberg, Jens

1996-01-01

Partial-evaluation folklore has it that massaging one's source programs can make them specialize better. In Jones, Gomard, and Sestoft's recent textbook, a whole chapter is dedicated to listing such “binding-time improvements”: nonstandard use of continuation-passing style, eta-expansion, and a p......Partial-evaluation folklore has it that massaging one's source programs can make them specialize better. In Jones, Gomard, and Sestoft's recent textbook, a whole chapter is dedicated to listing such “binding-time improvements”: nonstandard use of continuation-passing style, eta...... across dynamic case expressions. This requirement precisely accounts for the nonstandard use of continuation-passing style encountered in partial evaluation. Eta-expansion thus acts as a uniform binding-time coercion between values and contexts, be they of function type, product type, or disjoint...

Isolation and characterisation of a dinucleotide microsatellite set for a parentage and biodiversity study in domestic guinea pig (Cavia porcellus

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Diana Aviles

2015-10-01

Full Text Available The domestic guinea pig is a valuable genetic resource because it is part of local folklore and food tradition in many South American countries. The economic importance of the guinea pig is due to its high feed efficiency and the quality of animal protein produced. For these reasons, our study is aimed to design a complete dinucleotide microsatellite marker set following international recommendation to assess the genetic diversity and genealogy management of guinea pigs. We selected a total of 20 microsatellites, looking for laboratory efficiency and good statistical parameters. The set was tested in 100 unrelated individuals of guinea pigs from Ecuador, Peru, Colombia, Bolivia and Spain. Our results show a high degree of polymorphisms with a total of 216 alleles and a mean number of 10.80±3.49 for markers with a combined exclusion probability of 0.99.

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study

DEFF Research Database (Denmark)

Song, Honglin; Ramus, Susan J; Kjaer, Susanne Krüger

2009-01-01

Because both ovarian and breast cancer are hormone-related and are known to have some predisposition genes in common, we evaluated 11 of the most significant hits (six with confirmed associations with breast cancer) from the breast cancer genome-wide association study for association with invasiv...

Folk Music, Song and Dance in Bohemia and Moravia

Czech Academy of Sciences Publication Activity Database

Vejvoda, Zdeněk

2007-01-01

Roč. 10, č. 3 (2007), s. 14-23 ISSN 1211-0264 Institutional research plan: CEZ:AV0Z90580513 Keywords : Traditional Music * Roma Folk Music * Bagpipe * Dulcimer * Folklorism Subject RIV: AC - Archeology, Anthropology, Ethnology

Sympozium věnované tvorbě Oresta Zilynského

Czech Academy of Sciences Publication Activity Database

Valášková, Naďa

2013-01-01

Roč. 100, č. 2 (2013), s. 231-232 ISSN 0009-0794 Institutional support: RVO:68378076 Keywords : Slavonic folklore * customs * the ukrainen literature Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.094, year: 2012

Kevin J. Kayes. Poe and the Printed Word.

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Anne Garrait-Bourrier

2006-04-01

Full Text Available Kevin Hayes est Associate Professor à l’université d’Oklahoma. Spécialiste de culture américaine, il a publié de nombreux ouvrages sur le livre et sur le monde de l’édition aux Etats-Unis, en particulier A Colonial Woman’s Bookshelf (1996 ou Folklore and Book Culture (1997. Il s’est également intéressé à certains écrivains canoniques américains comme Melville, auquel il a consacré trois ouvrages, et Henry James.

L’ouvrage qui nous intéresse ici réunit en fait les deux centres d’intérêt de ...

Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population.

Science.gov (United States)

Sundqvist, J; Xu, H; Vodolazkaia, A; Fassbender, A; Kyama, C; Bokor, A; Gemzell-Danielsson, K; D'Hooghe, T M; Falconer, H

2013-03-01

Is it possible to replicate the previously identified genetic association of four single-nucleotide polymorphisms (SNPs), rs12700667, rs7798431, rs1250248 and rs7521902, with endometriosis in a Caucasian population? A borderline association was observed for rs1250248 and endometriosis (P = 0.049). However, we could not replicate the other previously identified endometriosis-associated SNPs (rs12700667, rs7798431 and rs7521902) in the same population. Endometriosis is considered a complex disease, influenced by several genetic and environmental factors, as well as interactions between them. Previous studies have found genetic associations with endometriosis for SNPs at the 7p15 and 2q35 loci in a Caucasian population. Allele frequencies of SNPs were investigated in patients with endometriosis and controls. Blood samples and peritoneal biopsies were taken from a Caucasian female population consisting of 1129 patients with endometriosis and 831 controls. DNA was extracted for genotyping. The study was performed at a University hospital and research laboratories. A weak association with endometriosis (all stages) was observed for rs1250248 (P = 0.049). No significant associations were observed for the SNPs rs12700667, rs7798431 and rs7521902. A non-significant trend towards the association of rs1250248 with moderate/severe endometriosis was observed (odds ratio 1.18, 95% confidence interval 0.97-1.44). The inability to confirm all previous findings may result from differences between populations and type II errors. Our result demonstrates the difficulty of identifying common genetic variants in complex diseases. This study was supported by grants from the Karolinska Institutet and Stockholm City County/Karolinska Institutet (ALF), Stockholm, Sweden, Swedish Medical Research Council (K2007-54X-14212-06-3, K2010-54X-14212-09-3), Stockholm, Sweden, Leuven University Research Council (Onderzoeksraad KU Leuven), the Leuven University Hospitals Clinical Research Foundation

Toppar: an interactive browser for viewing association study results.

Science.gov (United States)

Juliusdottir, Thorhildur; Banasik, Karina; Robertson, Neil R; Mott, Richard; McCarthy, Mark I

2018-06-01

Data integration and visualization help geneticists make sense of large amounts of data. To help facilitate interpretation of genetic association data we developed Toppar, a customizable visualization tool that stores results from association studies and enables browsing over multiple results, by combining features from existing tools and linking to appropriate external databases. Detailed information on Toppar's features and functionality are on our website http://mccarthy.well.ox.ac.uk/toppar/docs along with instructions on how to download, install and run Toppar. Our online version of Toppar is accessible from the website and can be test-driven using Firefox, Safari or Chrome on sub-sets of publicly available genome-wide association study anthropometric waist and body mass index data (Locke et al., 2015; Shungin et al., 2015) from the Genetic Investigation of ANthropometric Traits consortium. totajuliusd@gmail.com.

Usos en medicina folclórica, actividad biológica y fitoquímica de metabolitos secundarios de algunas especies del género Zanthoxylum

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Víctor Enríque Macias Villamizar

2013-10-01

tonic, diuretics, sedatives among others; but also determined its biological activity like cytotoxic antispasmodic and (5. In the Rutaceae family is the Zanthoxylum genus (6, of which also it is used in medicine folkloric which they include treatments against the cough, enteritis, diarrheic, refried, rheumatism and ulcerations (7, 8, 9, 10, 11; also its biological activity has been tried where it was to be effective, among others: antimicrobial (7, 8, 9; cytotoxic (12, 13; antiaggregation platelet (14, 15, and antitumoral (16. The ample range of ethnobotanics and pharmacological uses turns to the isolated extracts (or compounds of the Zanthoxylum genus in raw material to use in the development of tests to evaluate the biological activity, which is associate to the wealth of secondary metabolites such as alkaloids, lignans, terpenes, flavonoids, coumarins, among others; turning to the Zanthoxylum genus object of it studied promissory phytochemistry. In this article a contribution is made to study of the Zanthoxylum genus, in aspects related to its phytochemistry, its uses in medicine folkloric and its biological activity; and consequently a pertinent contribution to the knowledge in the Faculty of Sciences of the Health, Due to the current trend of using natural Medina for the development of drugs for relatively low cost and with a higher probability of acquiring the same.Key words: Rutaceae; Zanthoxylum; phytochemistry; medicine folkloric; biological activity.

Lipid nanotechnologies for structural studies of membrane-associated proteins.

Science.gov (United States)

Stoilova-McPhie, Svetla; Grushin, Kirill; Dalm, Daniela; Miller, Jaimy

2014-11-01

We present a methodology of lipid nanotubes (LNT) and nanodisks technologies optimized in our laboratory for structural studies of membrane-associated proteins at close to physiological conditions. The application of these lipid nanotechnologies for structure determination by cryo-electron microscopy (cryo-EM) is fundamental for understanding and modulating their function. The LNTs in our studies are single bilayer galactosylceramide based nanotubes of ∼20 nm inner diameter and a few microns in length, that self-assemble in aqueous solutions. The lipid nanodisks (NDs) are self-assembled discoid lipid bilayers of ∼10 nm diameter, which are stabilized in aqueous solutions by a belt of amphipathic helical scaffold proteins. By combining LNT and ND technologies, we can examine structurally how the membrane curvature and lipid composition modulates the function of the membrane-associated proteins. As proof of principle, we have engineered these lipid nanotechnologies to mimic the activated platelet's phosphtaidylserine rich membrane and have successfully assembled functional membrane-bound coagulation factor VIII in vitro for structure determination by cryo-EM. The macromolecular organization of the proteins bound to ND and LNT are further defined by fitting the known atomic structures within the calculated three-dimensional maps. The combination of LNT and ND technologies offers a means to control the design and assembly of a wide range of functional membrane-associated proteins and complexes for structural studies by cryo-EM. The presented results confirm the suitability of the developed methodology for studying the functional structure of membrane-associated proteins, such as the coagulation factors, at a close to physiological environment. © 2014 Wiley Periodicals, Inc.

Therapeutic properties of meswak chewing sticks: A review

African Journals Online (AJOL)

Administrator

2012-10-16

Oct 16, 2012 ... meswak in respect of oral hygiene and dental health are partly due to ... The World Health Organization has recommended ... information about the folklore uses, knowledge of local ..... phytochemical profile of the parent plant.

Pop / Koit Raudsepp

Index Scriptorium Estoniae

Raudsepp, Koit

2004-01-01

Heliplaatidest: Raekwon "The Lex Diamond Story", Nelly Furtado "Folklore", The Distillers "Coral Fang", Erinevad esitajad "The Texas Chainsaw Massacre - The Album", Soel (Ohse, Pascal & St Germain) "Memento", Donato Wharton "Trabanten", The Von Bondies "Pawn Shoppe Heart"

On the composition of modal structures of Tuvan traditional songs

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Ayasmaa D.-B. Baranmaa

2017-06-01

Full Text Available One of the most important aspects of musical language of song folklore of Tuvans – the scale – is as yet underinvestigated in contemporary Tuvan musicology. The author is studying the effect of structural principles in scale and sound gamut of Tuvan folk songs. The theory of monodic scales (S.P. Galitskaya, E.V. Gertsman, Yu.G. Kon, Kh.S. Kushnarev, etc. forms the methodological basis for the analysis. The object of our studies are manuscripts of traditional Tuvan songs published by Russian musicologists (A. N. Aksenov, Z. K. Kyrgys, etc. serves as material base for analysis. The analysis revealed that traditional Tuvan songs are usually based on two- or three-part composite gamut structures. This significantly enriched the substantial aspect of the process by complicating types of links between the sounds, making the medium more profound, compact and complete. Scale links and subscales were detected that can interconnect in four manners (discrete, monolithic, catenary, inclusive. Conjunction principles are illustrated by a few folk songs. Catenary and inclusive manners of conjunctions have been noticed to be dominating. A vast variety of different link combinations has been detected. This is a point where intonational abundance of folklore melos reveals its inexhaustibility.

The framework of studying personal and family stories

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Dragana Antonijević

2016-02-01

Full Text Available In this paper I suggest the analytical framework for interpreting personal and family stories about the loss of possessions, riches, job, reputation and status. I find the theoretic foothold in the decades long folkloristic and anthropological studies of personal stories and life histories, then in the concept by Gary Alan Fine, a sociologist and folklorist, about the idioculture of small groups through the discussion of the family folklore, and last in the discussion of the historic, social-economic and ideological context where personal and family losses occur. The incentive for me to deal with this type of stories resides in the fact that they have not been the subject of scientific analysis, neither in the world, nor in our country, except one work by an American folklorist Stanley Brandes from 1975, which served as my inspiration and model. The material for the analysis was collected in the form of term papers written by four generations of ethnology and anthropology third year students, attending the course in Folklore anthropology at the Ethnology and Anthropology Department of the Faculty of Philosophy of Belgrade University. A typology of these stories has been done, and they are divided into two groups with subtypes: stories about personal causes to material ruin, and about faith (destiny causing the ruin. Further on in the analysis I focused only on the context of the stories with the so-called "pre-destined (faith" causes of ruin, i.e., on the historic, social-economic and ideological changes in Serbia, which happened during the 20th and at the beginning of the 21st century. The context of the revolutionary takeover of power by the Communists after the World War Two is discussed, as well as the violent dispossession of what was until then private property of many families in Serbia, and transferring that property into state and social possession (the so-called stories about nationalization, and also the specific context of post

Outcomes of Global Education: External and Internal Change Associated with Study Abroad

Science.gov (United States)

Miller-Perrin, Cindy; Thompson, Don

2014-01-01

This chapter provides an overview of external and internal changes associated with collegiate study abroad experiences. A brief review of the research literature is included along with recent research that sheds light on potential mechanisms associated with study abroad-related change. Recommendations for enhancing outcomes associated with study…

Analgesic activity of Nelsonia canescens (Lam.) Spreng.root in albino rats

OpenAIRE

Mohaddesi, Behzad; Dwivedi, Ravindra; Ashok, B. K.; Aghera, Hetal; Acharya, Rabinarayan; Shukla, V. J.

2013-01-01

Present study was undertaken to evaluate analgesic activity of root of Nelsonia canescens (Lam.) Spreng, a folklore medicinal plant used as the one of the source plant of Rasna. Study was carried out at two dose levels (270 mg/kg and 540 mg/kg) in albino rats. Analgesic activity was evaluated in formalin induced paw licking, and tail flick methods whereas indomethacin and pentazocine were used as standard analgesic drugs, respectively. At both the dose levels, test drug non-significantly decr...

Novel loci associated with usual sleep duration: The CHARGE Consortium Genome-Wide Association Study

NARCIS (Netherlands)

D.J. Gottlieb (Daniel J); K. Hek (Karin); T.-H. Chen; N.F. Watson; G. Eiriksdottir (Gudny); E.M. Byrne; M. Cornelis (Marilyn); S.C. Warby; S. Bandinelli; L. Cherkas (Lynn); D.S. Evans (Daniel); H.J. Grabe (Hans Jörgen); J. Lahti (Jari); M. Li (Man); T. Lehtimäki (Terho); T. Lumley (Thomas); K. Marciante (Kristin); L. Perusse (Louis); B.M. Psaty (Bruce); J. Robbins; G.J. Tranah (Gregory); J.M. Vink; J.B. Wilk; J.M. Stafford; C. Bellis (Claire); R. Biffar; C. Bouchard (Claude); B. Cade; G.C. Curhan (Gary); J. Eriksson; R. Ewert; L. Ferrucci (Luigi); T. Fülöp; P.R. Gehrman (Philip); R. Goodloe (Robert); T.B. Harris (Tamara); A.C. Heath (Andrew C.); D.G. Hernandez (Dena); A. Hofman (Albert); J.J. Hottenga (Jouke Jan); D. Hunter (David); M.K. Jensen (Majken K.); A.D. Johnson (Andrew); M. Kähönen (Mika); W.H.L. Kao (Wen); P. Kraft (Peter); E.K. Larkin; D.S. Lauderdale; A.I. Luik (Annemarie I); M. Medici; G.W. Montgomery (Grant W.); A. Palotie; S.R. Patel (Sanjay); G. Pistis (Giorgio); E. Porcu; L. Quaye (Lydia); O. Raitakari (Olli); S. Redline (Susan); E.B. Rimm (Eric B.); J.I. Rotter; A.V. Smith; T.D. Spector (Timothy); A. Teumer (Alexander); A.G. Uitterlinden (André); M.-C. Vohl (Marie-Claude); E. Widen; G.A.H.M. Willemsen (Gonneke); T.L. Young (Terri L.); X. Zhang; Y. Liu; J. Blangero (John); D.I. Boomsma (Dorret); V. Gudnason (Vilmundur); F. Hu; M. Mangino; N.G. Martin (Nicholas); G.T. O'Connor (George); K.L. Stone (Katie L); T. Tanaka; J. Viikari (Jorma); S.A. Gharib (Sina); N.M. Punjabi (Naresh); K. Räikkönen (Katri); H. Völzke (Henry); E. Mignot; H.W. Tiemeier (Henning)

2015-01-01

textabstractUsual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18

Non-replication study of a genome-wide association study for hypertension and blood pressure in African Americans

Directory of Open Access Journals (Sweden)

Kidambi Srividya

2012-04-01

Full Text Available Abstract Background A recent genome wide association study in 1017 African Americans identified several single nucleotide polymorphisms that reached genome-wide significance for systolic blood pressure. We attempted to replicate these findings in an independent sample of 2474 unrelated African Americans in the Milwaukee metropolitan area; 53% were women and 47% were hypertensives. Methods We evaluated sixteen top associated SNPs from the above genome wide association study for hypertension as a binary trait or blood pressure as a continuous trait. In addition, we evaluated eight single nucleotide polymorphisms located in two genes (STK-39 and CDH-13 found to be associated with systolic and diastolic blood pressures by other genome wide association studies in European and Amish populations. TaqMan MGB-based chemistry with fluorescent probes was used for genotyping. We had an adequate sample size (80% power to detect an effect size of 1.2-2.0 for all the single nucleotide polymorphisms for hypertension as a binary trait, and 1% variance in blood pressure as a continuous trait. Quantitative trait analyses were performed both by excluding and also by including subjects on anti-hypertensive therapy (after adjustments were made for anti-hypertensive medications. Results For all 24 SNPs, no statistically significant differences were noted in the minor allele frequencies between cases and controls. One SNP (rs2146204 showed borderline association (p = 0.006 with hypertension status using recessive model and systolic blood pressure (p = 0.02, but was not significant after adjusting for multiple comparisons. In quantitative trait analyses, among normotensives only, rs12748299 was associated with SBP (p = 0.002. In addition, several nominally significant associations were noted with SBP and DBP among normotensives but none were statistically significant. Conclusions This study highlights the importance of replication to confirm the validity of genome wide

Books received by the Rijksherbarium library

NARCIS (Netherlands)

NN,

1977-01-01

This richly illustrated book shows many of the most common and most spectacular species of fungi found in Western Europe. The text is very popular and touches such items as poisionousness, edibility, culinary instructions, prejudices, and folklore.

Dětská folklorní komunikace v rýmech - možnosti interdisciplinárního přístupu

Czech Academy of Sciences Publication Activity Database

Pospíšilová, Jana; Uhlíková, Lucie

2011-01-01

Roč. 59, č. 1 (2011), s. 29-46 ISSN 1335-1303 Institutional research plan: CEZ:AV0Z90580513 Keywords : children's culture * children's communication * children's rhytmes * folklore * developmental psychology * psychoanalysis Subject RIV: AC - Archeology, Anthropology, Ethnology

Rahvusvaheline erialabibliograafia sündis Eestis / Piret Voolaid

Index Scriptorium Estoniae

Voolaid, Piret, 1971-

2005-01-01

Rets. rmt.: Internationale volkskundliche Bibliographie = International Folklore Bibliographie = Bibliographie internationale d'Ethnologie: Für das Jahr 1993 : mit Nachträgen für die vorausgehenden / herausgegeben von Karin Maria Rooleid. Bonn : Dr. Rudolf Habelt GMBH, 2004

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

NARCIS (Netherlands)

Gottlieb, D.J.; Hek, K.; Chen, T.H.; Watson, N.F.; Eiriksdottir, G.; Byrne, E.M.; Cornelis, M.; Warby, S.C.; Bandinelli, S.; Cherkas, L.; Evans, D.S.; Grabe, H.J.; Lahti, J.; Li, M.; Lehtimäki, T.; Lumley, T.; Marciante, K.; Pérusse, L.; Psaty, B.M.; Robbins, J.; Tranah, G.; Vink, J.M.; Wilk, J.B.; Stafford, J.M.; Bellis, M.; Biffar, R.; Bouchard, C.; Cade, B.; Curhan, G.C.; Eriksson, J.G.; Ewert, R.; Ferrucci, L.; Fülöp, T.; Gehrman, P.R.; Goodloe, R.; Harris, T.B.; Heath, A.C.; Hernandez, D.; Hofman, A.; Hottenga, J.J.; Hunter, D.J.; Jensen, M.K.; Johnson, A.D.; Kähönen, M.; Kao, L.; Kraft, P.; Larkin, E.K.; Lauderdale, D.S.; Luik, A.I.; Medici, M.; Montgomery, G.W.; Palotie, A.; Patel, S.R.; Pistis, G.; Porcu, E.; Quaye, L.; Raitakari, O.; Redline, S.; Rimm, E.B.; Rotter, J.I.; Smith, A.V.; Spector, T.D.; Teumer, A.; Uitterlinden, A.G.; Vohl, M.-C.; Widén, E.; Willemsen, G.; Young, T.; Zhang, X.; Liu, Y.; Blanger, J.; Boomsma, D.I.; Gudnason, V.; Hu, F.; Mangino, M.; Martin, N.G.; O'Connor, G.T.; Stone, K.L.; Tanaka, T.; Viikari, J.; Gharib, S.A.; Punjabi, N.M.; Räikkönen, K.; Völzke, H.; Mignot, E.; Tiemeier, H.

2015-01-01

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

NARCIS (Netherlands)

D.B. Hancock (Dana); M. Eijgelsheim (Mark); J.B. Wilk (Jemma); S.A. Gharib (Sina); L.R. Loehr (Laura); K. Marciante (Kristin); N. Franceschini (Nora); Y.M.T.A. van Durme; T.H. Chen; R.G. Barr (Graham); M.B. Schabath (Matthew); D.J. Couper (David); G.G. Brusselle (Guy); B.M. Psaty (Bruce); P. Tikka-Kleemola (Päivi); J.I. Rotter (Jerome); A.G. Uitterlinden (André); A. Hofman (Albert); N.M. Punjabi (Naresh); F. Rivadeneira Ramirez (Fernando); A.C. Morrison (Alanna); P.L. Enright (Paul); K.E. North (Kari); S.R. Heckbert (Susan); T. Lumley (Thomas); B.H.Ch. Stricker (Bruno); G.T. O'Connor (George); S.J. London (Stephanie)

2010-01-01

textabstractSpirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and

A genome-wide association study of attempted suicide

Science.gov (United States)

Willour, Virginia L.; Seifuddin, Fayaz; Mahon, Pamela B.; Jancic, Dubravka; Pirooznia, Mehdi; Steele, Jo; Schweizer, Barbara; Goes, Fernando S.; Mondimore, Francis M.; MacKinnon, Dean F.; Perlis, Roy H.; Lee, Phil Hyoun; Huang, Jie; Kelsoe, John R.; Shilling, Paul D.; Rietschel, Marcella; Nöthen, Markus; Cichon, Sven; Gurling, Hugh; Purcell, Shaun; Smoller, Jordan W.; Craddock, Nicholas; DePaulo, J. Raymond; Schulze, Thomas G.; McMahon, Francis J.; Zandi, Peter P.; Potash, James B.

2011-01-01

The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. While attempted suicide linkage regions have been identified on 2p11–12 and 6q25–26, there are likely many more such loci, the discovery of which will require a much higher resolution approach, such as the genome-wide association study (GWAS). With this in mind, we conducted an attempted suicide GWAS that compared the single nucleotide polymorphism (SNP) genotypes of 1,201 bipolar (BP) subjects with a history of suicide attempts to the genotypes of 1,497 BP subjects without a history of suicide attempts. 2,507 SNPs with evidence for association at p<0.001 were identified. These associated SNPs were subsequently tested for association in a large and independent BP sample set. None of these SNPs were significantly associated in the replication sample after correcting for multiple testing, but the combined analysis of the two sample sets produced an association signal on 2p25 (rs300774) at the threshold of genome-wide significance (p= 5.07 × 10−8). The associated SNPs on 2p25 fall in a large linkage disequilibrium block containing the ACP1 gene, a gene whose expression is significantly elevated in BP subjects who have completed suicide. Furthermore, the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. Larger GWAS sample sets will be required to confirm the signal on 2p25 and to identify additional genetic risk factors increasing susceptibility for attempted suicide. PMID:21423239

Susceptibility to chronic mucus hypersecretion, a genome wide association study.

Directory of Open Access Journals (Sweden)

Akkelies E Dijkstra

Full Text Available Chronic mucus hypersecretion (CMH is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA study of CMH in Caucasian populations.GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years. Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism (SNP.A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25×10(-6, OR = 1.17, located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1 on chromosome 3. The risk allele (G was associated with higher mRNA expression of SATB1 (4.3×10(-9 in lung tissue. Presence of CMH was associated with increased SATB1 mRNA expression in bronchial biopsies from COPD patients. SATB1 expression was induced during differentiation of primary human bronchial epithelial cells in culture.Our findings, that SNP rs6577641 is associated with CMH in multiple cohorts and is a cis-eQTL for SATB1, together with our additional observation that SATB1 expression increases during epithelial differentiation provide suggestive evidence that SATB1 is a gene that affects CMH.

An Entropy-Based Statistic for Genomewide Association Studies

OpenAIRE

Zhao, Jinying; Boerwinkle, Eric; Xiong, Momiao

2005-01-01

Efficient genotyping methods and the availability of a large collection of single-nucleotide polymorphisms provide valuable tools for genetic studies of human disease. The standard χ2 statistic for case-control studies, which uses a linear function of allele frequencies, has limited power when the number of marker loci is large. We introduce a novel test statistic for genetic association studies that uses Shannon entropy and a nonlinear function of allele frequencies to amplify the difference...

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies

DEFF Research Database (Denmark)

Yang, Xiaohong R; Chang-Claude, Jenny; Goode, Ellen L

2011-01-01

Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors.......Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors....

Resurrection, revenance, and exhumation: the problematics of the dead body in songs and laments

Directory of Open Access Journals (Sweden)

Madis Arukask

2011-01-01

Full Text Available Different types of folklore texts differ from each other by their function. We can distinguish between genres meant to be believed (like legend and genres recognized in advance as fiction (fairy-tale. At the same time, textual fiction may also have served practical purposes—such as the telling of fairy-tales during the late autumn and early winter for purposes of fertility magic—as used to be the case in the Estonian folk tradition. There are folklore genres that have functioned, among other things, as an accompaniment, comment on, or support to rituals or practices being carried out—for instance, an incantation during a cure, or a lament in death-related procedures, when a person must be separated from his familiar environment. The same textual formulae fulfil different tasks in different genres, which means that they also carry a different meaning. The present paper considers some themes related to the bodily aspect of humanity in various genres of folklore, particularly in songs and laments, as well as in practices related to death and commemoration. As expected, the problems connected with the human body have in these genres undergone transformations of meaning, the understanding and interpretation of which may vary considerably. The mater­ial discussed in the article derives mainly from the Balto-Finnic and north Russian cultural area, partly from the author's own experience during his field trips.

THE PROBLEM OF THE PLOT AND THE GENRE IN N. A. RADISHCHEV’S “CHURILA PLENKOVICH, BOGATYR SONGWRITING”

Directory of Open Access Journals (Sweden)

Olga V. Zakharova

2017-03-01

Full Text Available In the 18th–19th centuries, attempts to appropriate folklore heroes and genres in literature were made. One of such literary works was N. A. Radishchev’s poem (1801 where the epic hero Churila Plenkovich became a character. Imitating the folkloric and literary tradition (Homer, Virgil, Ariosto, Voltaire, Wieland, V. A. Levshin, I. P. Bogdanovich, the author combined the images and motives of such genres as bylina (Russian epic song, fairy and literary tale, heroic and comic poem in his work. Using the storyline and retaining the main motives of Levshin’s tale, the poet added mythological and fairy images (Zmey Gorynych (dragon, Yaga, Lel’ (Lel’o, Lada to his writing, supplemented the narrative with new motives, and gave justifications for the heroes’ actions. Radishchev created literary heroes using fairytale types; he showed their sufferings, emotions and feelings. Radishchev’s Churila lost all features of the bogatyr. He is a literary hero — a handsome, good-looking, ardent and sensitive young man. Prelepa and Yaga have fallen in love with him. His feats represent a plot of romance and adventure novel; his heroic deeds are inspired by Lel’o, a god of love who gives the bogatyr strength. As a result of these transformations, an original fabulous plot and genre of the literary work appeared. The writer is precise in his defining: his Churila is a character of the epic story in verse based on folkloric and literary tale.

Ofori-Kwakye et al., Afr J Tradit Complement Altern Med. (2011) 8(3 ...

African Journals Online (AJOL)

AJTCAM

(Bignoniaceae) is a plant species used in folkloric medicine in Ghana and several .... extract was shown to be acidic and the pH remained stable throughout .... wound contraction or healing process was accelerated by the application of S.

'Jeden vel'ký kolektív': Folklór ako vystúpenie a organizácia

Czech Academy of Sciences Publication Activity Database

Feinberg, Joseph Grim

2016-01-01

Roč. 48, č. 4 (2016), s. 357-376 ISSN 0049-1225 Institutional support: RVO:67985955 Keywords : folklore * performativity * public sphere and privacy * aesthetic theory * social theory Subject RIV: AO - Sociology, Demography Impact factor: 0.283, year: 2016

A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype.

Directory of Open Access Journals (Sweden)

Johanna Hass

Full Text Available Patients with schizophrenia and their siblings typically show subtle changes of brain structures, such as a reduction of hippocampal volume. Hippocampal volume is heritable, may explain a variety of cognitive symptoms of schizophrenia and is thus considered an intermediate phenotype for this mental illness. The aim of our analyses was to identify single-nucleotide polymorphisms (SNP related to hippocampal volume without making prior assumptions about possible candidate genes. In this study, we combined genetics, imaging and neuropsychological data obtained from the Mind Clinical Imaging Consortium study of schizophrenia (n = 328. A total of 743,591 SNPs were tested for association with hippocampal volume in a genome-wide association study. Gene expression profiles of human hippocampal tissue were investigated for gene regions of significantly associated SNPs. None of the genetic markers reached genome-wide significance. However, six highly correlated SNPs (rs4808611, rs35686037, rs12982178, rs1042178, rs10406920, rs8170 on chromosome 19p13.11, located within or in close proximity to the genes NR2F6, USHBP1, and BABAM1, as well as four SNPs in three other genomic regions (chromosome 1, 2 and 10 had p-values between 6.75×10(-6 and 8.3×10(-7. Using existing data of a very recently published GWAS of hippocampal volume and additional data of a multicentre study in a large cohort of adolescents of European ancestry, we found supporting evidence for our results. Furthermore, allelic differences in rs4808611 and rs8170 were highly associated with differential mRNA expression in the cis-acting region. Associations with memory functioning indicate a possible functional importance of the identified risk variants. Our findings provide new insights into the genetic architecture of a brain structure closely linked to schizophrenia. In silico replication, mRNA expression and cognitive data provide additional support for the relevance of our findings

Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study

DEFF Research Database (Denmark)

Dijkstra, Akkelies E; Smolonska, Joanna; van den Berge, Maarten

2014-01-01

by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years). Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism...... (SNP). RESULTS: A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25×10(-6), OR = 1.17), located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1) on chromosome 3. The risk allele (G) was associated with higher mRNA expression...... of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations. METHODS: GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed...

The Cultural Roots of Teacher Associations: A Case Study from India

Science.gov (United States)

Padwad, Amol

2016-01-01

Teacher associations (TAs) are communities located in complex cultural spaces that may affect their functioning, vision, priorities, and policies. This case study of the English Language Teachers' Association of India (ELTAI) attempts to examine the relationship between the Association and the cultural space it inhabits, with specific reference to…

A genome-wide association study of aging.

Science.gov (United States)

Walter, Stefan; Atzmon, Gil; Demerath, Ellen W; Garcia, Melissa E; Kaplan, Robert C; Kumari, Meena; Lunetta, Kathryn L; Milaneschi, Yuri; Tanaka, Toshiko; Tranah, Gregory J; Völker, Uwe; Yu, Lei; Arnold, Alice; Benjamin, Emelia J; Biffar, Reiner; Buchman, Aron S; Boerwinkle, Eric; Couper, David; De Jager, Philip L; Evans, Denis A; Harris, Tamara B; Hoffmann, Wolfgang; Hofman, Albert; Karasik, David; Kiel, Douglas P; Kocher, Thomas; Kuningas, Maris; Launer, Lenore J; Lohman, Kurt K; Lutsey, Pamela L; Mackenbach, Johan; Marciante, Kristin; Psaty, Bruce M; Reiman, Eric M; Rotter, Jerome I; Seshadri, Sudha; Shardell, Michelle D; Smith, Albert V; van Duijn, Cornelia; Walston, Jeremy; Zillikens, M Carola; Bandinelli, Stefania; Baumeister, Sebastian E; Bennett, David A; Ferrucci, Luigi; Gudnason, Vilmundur; Kivimaki, Mika; Liu, Yongmei; Murabito, Joanne M; Newman, Anne B; Tiemeier, Henning; Franceschini, Nora

2011-11-01

Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis of genome-wide association studies from 9 studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium for 2 outcomes: (1) all-cause mortality, and (2) survival free of major disease or death. No single nucleotide polymorphism (SNP) was a genome-wide significant predictor of either outcome (p < 5 × 10(-8)). We found 14 independent SNPs that predicted risk of death, and 8 SNPs that predicted event-free survival (p < 10(-5)). These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are associated with risk of various diseases including cancer and Alzheimer's disease. In addition to considerable overlap between the traits, pathway and network analysis corroborated these findings. These findings indicate that variation in genes involved in neurological processes may be an important factor in regulating aging free of major disease and achieving longevity. Copyright © 2011 Elsevier Inc. All rights reserved.

Microbiome-wide association studies link dynamic microbial consortia to disease

Energy Technology Data Exchange (ETDEWEB)

Gilbert, Jack A.; Quinn, Robert A.; Debelius, Justine; Xu, Zhenjiang Z.; Morton, James; Garg, Neha; Jansson, Janet K.; Dorrestein, Pieter C.; Knight, Rob

2016-07-06

Rapid advances in DNA sequencing, metabolomics, proteomics and computation dramatically increase accessibility of microbiome studies and identify links between the microbiome and disease. Microbial time-series and multiple molecular perspectives enable Microbiome-Wide Association Studies (MWAS), analogous to Genome-Wide Association Studies (GWAS). Rapid research advances point towards actionable results, although approved clinical tests based on MWAS are still in the future. Appreciating the complexity of interactions between diet, chemistry, health and the microbiome, and determining the frequency of observations needed to capture and integrate this dynamic interface, is paramount for addressing the need for personalized and precision microbiome-based diagnostics and therapies.

Scandinavian belief in fate

Directory of Open Access Journals (Sweden)

Åke Ström

1967-02-01

Full Text Available In point of principle, Christianity does not give room for any belief in fate. Astrology, horoscopes, divination, etc., are strictly rejected. Belief in fate never disappeared in Christian countries, nor did it in Scandinavia in Christian times. Especially in folklore we can find it at any period: People believed in an implacable fate. All folklore is filled up with this belief in destiny. Nobody can escape his fate. The future lies in the hands of fate, and the time to come takes its form according to inscrutable laws. The pre-Christian period in Scandinavia, dominated by pagan Norse religion, and the secularized epoch of the 20th century, however, show more distinctive and more widespread beliefs in fate than does the Christian period. The present paper makes a comparison between these forms of belief.

Genome-wide association study identifies novel locus for neuroticism and shows polygenic association with Major Depressive Disorder

Science.gov (United States)

de Moor, Marleen H.M.; van den Berg, Stéphanie M.; Verweij, Karin J.H.; Krueger, Robert F.; Luciano, Michelle; Vasquez, Alejandro Arias; Matteson, Lindsay K.; Derringer, Jaime; Esko, Tõnu; Amin, Najaf; Gordon, Scott D.; Hansell, Narelle K.; Hart, Amy B.; Seppälä, Ilkka; Huffman, Jennifer E.; Konte, Bettina; Lahti, Jari; Lee, Minyoung; Miller, Mike; Nutile, Teresa; Tanaka, Toshiko; Teumer, Alexander; Viktorin, Alexander; Wedenoja, Juho; Abecasis, Goncalo R.; Adkins, Daniel E.; Agrawal, Arpana; Allik, Jüri; Appel, Katja; Bigdeli, Timothy B.; Busonero, Fabio; Campbell, Harry; Costa, Paul T.; Smith, George Davey; Davies, Gail; de Wit, Harriet; Ding, Jun; Engelhardt, Barbara E.; Eriksson, Johan G.; Fedko, Iryna O.; Ferrucci, Luigi; Franke, Barbara; Giegling, Ina; Grucza, Richard; Hartmann, Annette M.; Heath, Andrew C.; Heinonen, Kati; Henders, Anjali K.; Homuth, Georg; Hottenga, Jouke-Jan; Janzing, Joost; Jokela, Markus; Karlsson, Robert; Kemp, John P.; Kirkpatrick, Matthew G.; Latvala, Antti; Lehtimäki, Terho; Liewald, David C.; Madden, Pamela A.F.; Magri, Chiara; Magnusson, Patrik K.E.; Marten, Jonathan; Maschio, Andrea; Medland, Sarah E.; Mihailov, Evelin; Milaneschi, Yuri; Montgomery, Grant W.; Nauck, Matthias; Ouwens, Klaasjan G.; Palotie, Aarno; Pettersson, Erik; Polasek, Ozren; Qian, Yong; Pulkki-Råback, Laura; Raitakari, Olli T.; Realo, Anu; Rose, Richard J.; Ruggiero, Daniela; Schmidt, Carsten O.; Slutske, Wendy S.; Sorice, Rossella; Starr, John M.; Pourcain, Beate St; Sutin, Angelina R.; Timpson, Nicholas J.; Trochet, Holly; Vermeulen, Sita; Vuoksimaa, Eero; Widen, Elisabeth; Wouda, Jasper; Wright, Margaret J.; Zgaga, Lina; Scotland, Generation; Porteous, David; Minelli, Alessandra; Palmer, Abraham A.; Rujescu, Dan; Ciullo, Marina; Hayward, Caroline; Rudan, Igor; Metspalu, Andres; Kaprio, Jaakko; Deary, Ian J.; Räikkönen, Katri; Wilson, James F.; Keltikangas-Järvinen, Liisa; Bierut, Laura J.; Hettema, John M.; Grabe, Hans J.; van Duijn, Cornelia M.; Evans, David M.; Schlessinger, David; Pedersen, Nancy L.; Terracciano, Antonio; McGue, Matt; Penninx, Brenda W.J.H.; Martin, Nicholas G.; Boomsma, Dorret I.

2015-01-01

Importance Neuroticism is a personality trait that is briefly defined by emotional instability. It is a robust genetic risk factor for Major Depressive Disorder (MDD) and other psychiatric disorders. Hence, neuroticism is an important phenotype for psychiatric genetics. The Genetics of Personality Consortium (GPC) has created a resource for genome-wide association analyses of personality traits in over 63,000 participants (including MDD cases). Objective To identify genetic variants associated with neuroticism by performing a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation, to evaluate if common genetic variants as assessed by Single Nucleotide Polymorphisms (SNPs) explain variation in neuroticism by estimating SNP-based heritability, and to examine whether SNPs that predict neuroticism also predict MDD. Setting 30 cohorts with genome-wide genotype, personality and MDD data from the GPC. Participants The study included 63,661 participants from 29 discovery cohorts and 9,786 participants from a replication cohort. Participants came from Europe, the United States or Australia. Main outcome measure(s) Neuroticism scores harmonized across all cohorts by Item Response Theory (IRT) analysis, and clinically assessed MDD case-control status. Results A genome-wide significant SNP was found in the MAGI1 gene (rs35855737; P=9.26 × 10−9 in the discovery meta-analysis, and P=2.38 × 10−8 in the meta-analysis of all 30 cohorts). Common genetic variants explain 15% of the variance in neuroticism. Polygenic scores based on the meta-analysis of neuroticism in 27 of the discovery cohorts significantly predicted neuroticism in 2 independent cohorts. Importantly, polygenic scores also predicted MDD in these cohorts. Conclusions and relevance This study identifies a novel locus for neuroticism. The variant is located in a known gene that has been associated with bipolar disorder and schizophrenia in previous studies. In addition, the study

Genome-wide association study of pancreatic cancer in Japanese population.

Directory of Open Access Journals (Sweden)

Siew-Kee Low

Full Text Available Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5x10(-7 with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30x10(-7, 3.30x10(-7, and 4.41x10(-7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations

DEFF Research Database (Denmark)

Demirkan, Ayşe; van Duijn, Cornelia M; Ugocsai, Peter

2012-01-01

, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57...

Pathway Analysis of Metabolic Syndrome Using a Genome-Wide Association Study of Korea Associated Resource (KARE Cohorts

Directory of Open Access Journals (Sweden)

Unjin Shim

2014-12-01

Full Text Available Metabolic syndrome (MetS is a complex disorder related to insulin resistance, obesity, and inflammation. Genetic and environmental factors also contribute to the development of MetS, and through genome-wide association studies (GWASs, important susceptibility loci have been identified. However, GWASs focus more on individual single-nucleotide polymorphisms (SNPs, explaining only a small portion of genetic heritability. To overcome this limitation, pathway analyses are being applied to GWAS datasets. The aim of this study is to elucidate the biological pathways involved in the pathogenesis of MetS through pathway analysis. Cohort data from the Korea Associated Resource (KARE was used for analysis, which include 8,842 individuals (age, 52.2 ± 8.9 years; body mass index, 24.6 ± 3.2 kg/m2. A total of 312,121 autosomal SNPs were obtained after quality control. Pathway analysis was conducted using Meta-analysis Gene-Set Enrichment of Variant Associations (MAGENTA to discover the biological pathways associated with MetS. In the discovery phase, SNPs from chromosome 12, including rs11066280, rs2074356, and rs12229654, were associated with MetS (p < 5 × 10-6, and rs11066280 satisfied the Bonferroni-corrected cutoff (unadjusted p < 1.38 × 10-7, Bonferroni-adjusted p < 0.05. Through pathway analysis, biological pathways, including electron carrier activity, signaling by platelet-derived growth factor (PDGF, the mitogen-activated protein kinase kinase kinase cascade, PDGF binding, peroxisome proliferator-activated receptor (PPAR signaling, and DNA repair, were associated with MetS. Through pathway analysis of MetS, pathways related with PDGF, mitogen-activated protein kinase, and PPAR signaling, as well as nucleic acid binding, protein secretion, and DNA repair, were identified. Further studies will be needed to clarify the genetic pathogenesis leading to MetS.

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis.

Science.gov (United States)

Orozco, Gisela; Goh, Chee L; Al Olama, Ali Amin; Benlloch-Garcia, Sara; Govindasami, Koveela; Guy, Michelle; Muir, Kenneth R; Giles, Graham G; Severi, Gianluca; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Kote-Jarai, Zsofia; Easton, Douglas F; Eyre, Steve; Eeles, Rosalind A

2013-06-01

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The link between inflammation and cancer has long been reported and inflammation is thought to play a role in the pathogenesis of many cancers, including prostate cancer (PrCa). Over the last 5 years, genome-wide association studies (GWAS) have reported numerous susceptibility loci that predispose individuals to many different traits. The present study aims to ascertain if there are common genetic risk profiles that might predispose individuals to both PrCa and the autoimmune inflammatory condition, rheumatoid arthritis. These results could have potential public heath impact in terms of screening and chemoprevention. To investigate if potential common pathways exist for the pathogenesis of autoimmune disease and prostate cancer (PrCa). To ascertain if the single nucleotide polymorphisms (SNPs) reported by genome-wide association studies (GWAS) as being associated with susceptibility to PrCa are also associated with susceptibility to the autoimmune disease rheumatoid arthritis (RA). The original Wellcome Trust Case Control Consortium (WTCCC) UK RA GWAS study was expanded to include a total of 3221 cases and 5272 controls. In all, 37 germline autosomal SNPs at genome-wide significance associated with PrCa risk were identified from a UK/Australian PrCa GWAS. Allele frequencies were compared for these 37 SNPs between RA cases and controls using a chi-squared trend test and corrected for multiple testing (Bonferroni). In all, 33 SNPs were able to be analysed in the RA dataset. Proxies could not be located for the SNPs in 3q26, 5p15 and for two SNPs in 17q12. After applying a Bonferroni correction for the number of SNPs tested, the SNP mapping to CCHCR1 (rs130067) retained statistically significant evidence for association (P = 6 × 10(-4) ; odds ratio [OR] = 1.15, 95% CI: 1.06-1.24); this has also been associated with psoriasis. However, further analyses showed that the association of this allele was due to

Study on drug costs associated with COPD prescription medicine in Denmark

DEFF Research Database (Denmark)

Jakobsen, M; Anker, N; Dollerup, J

2013-01-01

that the costs associated with COPD in Denmark are significant, but costs of prescription medicine for COPD were not analysed. OBJECTIVES: To analyse the societal costs associated with prescription medicine for COPD in Denmark. METHODS: The study was designed as a nationwide retrospective register study...... in 2010 with total costs of DKK 685 million (EUR 92 million). The average lifetime costs associated with COPD prescription medicine were estimated to be DKK 70,000-75,000 (EUR 9,416-10,089) per patient (2010 prices). CONCLUSION: The costs associated with prescription medicine for COPD in Denmark...... of the drug costs (ATC group R03) associated with COPD in the period 2001-2010. Data were retrieved from the Prescription Database, the National Patient Register and the Centralised Civil Register. The population comprised individuals (40+ years) who had at least one prescription of selected R03 drugs and who...

STUDY ON DRUG COSTS ASSOCIATED WITH COPD PRESCRIPTION MEDICINE IN DENMARK

DEFF Research Database (Denmark)

Jakobsen, Iris Marie; Anker, Niels; Dolleru, Jens

2012-01-01

that the costs associated with COPD in Denmark are significant, but costs of prescription medicine for COPD were not analysed. OBJECTIVES: To analyse the societal costs associated with prescription medicine for COPD in Denmark. METHODS: The study was designed as a nationwide retrospective register study...... in 2010 with total costs of DKK 685 million (EUR 92 million). The average lifetime costs associated with COPD prescription medicine were estimated to be DKK 70,000-75,000 (EUR 9,416-10,089) per patient (2010 prices). CONCLUSION: The costs associated with prescription medicine for COPD in Denmark...... of the drug costs (ATC group R03) associated with COPD in the period 2001-2010. Data were retrieved from the Prescription Database, the National Patient Register and the Centralised Civil Register. The population comprised individuals (40+ years) who had at least one prescription of selected R03 drugs and who...

A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study)

NARCIS (Netherlands)

Meulenbelt, I.; Bijkerk, C.; Miedema, H.S.; Breedveld, F.C.; Hofman, A.; Valkenburg, H.A.; Pols, H.A.P.; Slagboom, P.E.; Duijn, C.M. van

1998-01-01

Objective - A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. Methods - Subjects aged 55-65 years were selected from a population-based study of which ROA at

Study on drug costs associated with COPD prescription medicine in Denmark.

Science.gov (United States)

Jakobsen, Marie; Anker, Niels; Dollerup, Jens; Poulsen, Peter Bo; Lange, Peter

2013-10-01

Spirometric studies of the general population estimate that 430 000 Danes have chronic obstructive pulmonary disease (COPD). COPD is mainly caused by smoking, and smoking cessation is the most important intervention to prevent disease progression. Cost-of-illness studies conclude that the costs associated with COPD in Denmark are significant, but costs of prescription medicine for COPD were not analysed. To analyse the societal costs associated with prescription medicine for COPD in Denmark. The study was designed as a nationwide retrospective register study of the drug costs (ATC group R03) associated with COPD in the period 2001-2010. Data were retrieved from the Prescription Database, the National Patient Register and the Centralised Civil Register. The population comprised individuals (40+ years) who had at least one prescription of selected R03 drugs and who had been either hospitalised with a COPD diagnosis or had at least one prescription for drugs primarily used for COPD. The study population comprised 166 462 individuals of which 97 916 were alive on 31 December 2010. The average annual drug costs (R03) were DKK 7842 (EUR 1055) per patient in 2010 with total costs of DKK 685 million (EUR 92 million). The average lifetime costs associated with COPD prescription medicine were estimated to be DKK 70 000-75 000 (EUR 9416-10 089) per patient (2010 prices). The costs associated with prescription medicine for COPD in Denmark are significant. © 2012 John Wiley & Sons Ltd.

Association of Torsion With Testicular Cancer: A Retrospective Study.

Science.gov (United States)

Uguz, Sami; Yilmaz, Sercan; Guragac, Ali; Topuz, Bahadır; Aydur, Emin

2016-02-01

Testicular torsion is a medical emergency that usually requires surgical exploration. However, testicular malignancy has been anecdotally reported with the association of torsion in surgical specimens, and the published data remain scant on the association of torsion with testicular tumors. By retrospective medical record review, we identified 32 patients who had been diagnosed with testicular torsion, 20 of whom had undergone orchiectomy. Of these 20 patients, 2 were diagnosed with a malignancy. Our study, the largest case series to date, has shown an association between testicular torsion and testicular cancer of 6.4%. Testicular torsion is a medical emergency that usually requires surgical exploration. However, testicular malignancy has been anecdotally reported in association with torsion in surgical specimens. However, the published data remain scant on the association between torsion and the presence of testicular tumors. The present retrospective study explored the association between torsion and testicular cancer in patients with testicular torsion undergoing orchiectomy during scrotal exploration. A medical record review was performed of patients who had had a diagnosis of testicular torsion from January 2003 to February 2015. The clinicopathologic characteristics of the patients were recorded. A total of 32 patients were identified. Their mean age was 21.1 years (range, 7-39 years). All the patients had unilateral testicular torsion, which affected the left side in 17 and the right side in 15. Manual detorsion was successful in 6 patients, and 26 patients underwent emergency surgery with testicular detorsion (6 fixation surgery and 20 orchiectomy). The type of incision was scrotal in 6, inguinal in 10, and unspecified in 4. Pathologic examination of the orchiectomy specimens showed malignancy in 2 cases (seminoma and malign mixed germ cell tumor). To the best of our knowledge, the present single-center case series is the largest case series to date of

Genome-wide association study of suicide attempts in mood disorder patients.

Science.gov (United States)

Perlis, Roy H; Huang, Jie; Purcell, Shaun; Fava, Maurizio; Rush, A John; Sullivan, Patrick F; Hamilton, Steven P; McMahon, Francis J; Schulze, Thomas G; Schulze, Thomas; Potash, James B; Zandi, Peter P; Willour, Virginia L; Penninx, Brenda W; Boomsma, Dorret I; Vogelzangs, Nicole; Middeldorp, Christel M; Rietschel, Marcella; Nöthen, Markus; Cichon, Sven; Gurling, Hugh; Bass, Nick; McQuillin, Andrew; Hamshere, Marian; Craddock, Nick; Sklar, Pamela; Smoller, Jordan W

2010-12-01

Family and twin studies suggest that liability for suicide attempts is heritable and distinct from mood disorder susceptibility. The authors therefore examined the association between common genomewide variation and lifetime suicide attempts. The authors analyzed data on lifetime suicide attempts from genomewide association studies of bipolar I and II disorder as well as major depressive disorder. Bipolar disorder subjects were drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder cohort, the Wellcome Trust Case Control Consortium bipolar cohort, and the University College London cohort. Replication was pursued in the NIMH Genetic Association Information Network bipolar disorder project and a German clinical cohort. Depression subjects were drawn from the Sequential Treatment Alternatives to Relieve Depression cohort, with replication in the Netherlands Study of Depression and Anxiety/Netherlands Twin Register depression cohort. Strongest evidence of association for suicide attempt in bipolar disorder was observed in a region without identified genes (rs1466846); five loci also showed suggestive evidence of association. In major depression, strongest evidence of association was observed for a single nucleotide polymorphism in ABI3BP, with six loci also showing suggestive association. Replication cohorts did not provide further support for these loci. However, meta-analysis incorporating approximately 8,700 mood disorder subjects identified four additional regions that met the threshold for suggestive association, including the locus containing the gene coding for protein kinase C-epsilon, previously implicated in models of mood and anxiety. The results suggest that inherited risk for suicide among mood disorder patients is unlikely to be the result of individual common variants of large effect. They nonetheless provide suggestive evidence for multiple loci, which merit further investigation.

Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis.

Science.gov (United States)

Alg, Varinder S; Ke, Xiayi; Grieve, Joan; Bonner, Stephen; Walsh, Daniel C; Bulters, Diederik; Kitchen, Neil; Houlden, Henry; Werring, David J

2018-01-15

Abnormalities in Matrix Metalloproteinase (MMP) genes, which are important in extracellular matrix (ECM) maintenance and therefore arterial wall integrity are a plausible underlying mechanism of intracranial aneurysm (IA) formation, growth and subsequent rupture. We investigated whether the rs243865 C > T SNP (single nucleotide polymorphism) within the MMP-2 gene (which influences gene transcription) is associated with IA compared to matched controls. We conducted a case-control genetic association study, adjusted for known IA risk factors (smoking and hypertension), in a UK Caucasian population of 1409 patients with intracranial aneurysms (IA), and 1290 matched controls, to determine the association of the rs243865 C > T functional MMP-2 gene SNP with IA (overall, and classified as ruptured and unruptured). We also undertook a meta-analysis of two previous studies examining this SNP. The rs243865 T allele was associated with IA presence in univariate (OR 1.18 [95% CI 1.04-1.33], p = .01) and in multi-variable analyses adjusted for smoking and hypertension status (OR 1.16 [95% CI 1.01-1.35], p = .042). Subgroup analysis demonstrated an association of the rs243865 SNP with ruptured IA (OR 1.18 [95% CI 1.03-1.34] p = .017), but, not unruptured IA (OR 1.17 [95% CI 0.97-1.42], p = .11). Our study demonstrated an association between the functional MMP-2 rs243865 variant and IAs. Our findings suggest a genetic role for altered extracellular matrix integrity in the pathogenesis of IA development and rupture.

Dinaka/kiba: A descriptive analysis of a Northern Sotho song-dance ...

African Journals Online (AJOL)

A disjuncture in the description of persists between practitioners of the genre, deemed custodians of Northern Sotho culture, and some scholars. Drawing from extensive fieldwork and ... song-dance performative compound. Keywords: Indigenous music, African drumming, African performance, African folklore, African dance.

Ehedat Bulgaariat avastamas / Leili Sägi

Index Scriptorium Estoniae

Sägi, Leili

2009-01-01

Bulgaarias Kiustendil said kokku viie riigi õpetajad, et valmistada ette 2011. aastal Prantsusmaal toimuvat õpilaste folkloorifestivali. Eestist osalevad kahel õppeaastal kestvas projektis "The folklore - an European intercultural link" Pärnu vene gümnaasiumi õpetajad ja 7-14-aastased õpilased

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

NARCIS (Netherlands)

A. Dehghan (Abbas); A. Köttgen (Anna); Q. Yang (Qiong Fang); S.J. Hwang; W.H.L. Kao (Wen); F. Rivadeneira Ramirez (Fernando); E.A. Boerwinkle (Eric); D. Levy (Daniel); A. Hofman (Albert); B.C. Astor (Brad); E.J. Benjamin (Emelia); P. Tikka-Kleemola (Päivi); J.C.M. Witteman (Jacqueline); J. Coresh (Josef); C.S. Fox (Caroline)

2008-01-01

textabstractBackground: Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout. Methods: Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham

The Prosocial Effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled Studies in Humans and Laboratory Animals

Science.gov (United States)

Kamilar-Britt, Philip; Bedi, Gillinder

2015-01-01

Users of ±3,4-Methylenedioxymethamphetamine (MDMA; ‘ecstasy’) report prosocial effects such as sociability and empathy. Supporting these apparently unique social effects, data from controlled laboratory studies indicate that MDMA alters social feelings, information processing, and behavior in humans, and social behavior in rodents. Here, we review this growing body of evidence. In rodents, MDMA increases passive prosocial behavior (adjacent lying) and social reward while decreasing aggression, effects that may involve serotonin 1A receptor mediated oxytocin release interacting with vasopressin receptor 1A. In humans, MDMA increases plasma oxytocin and produces feelings of social affiliation. It decreases identification of negative facial expressions (cognitive empathy) and blunts responses to social rejection, while enhancing responses to others’ positive emotions (emotional empathy) and increasing social approach. Thus, consistent with drug folklore, laboratory administration of MDMA robustly alters social processing in humans and increases social approach in humans and animals. Effects are consistent with increased sociability, with mixed evidence about enhanced empathy. These neurobiologically-complex prosocial effects likely motivate recreational ecstasy use. PMID:26408071

Genome-wide association study of autistic-like traits in a general population study of young adults

Directory of Open Access Journals (Sweden)

Rachel Maree Jones

2013-10-01

Full Text Available Research has proposed that autistic-like traits in the general population lie on a continuum, with clinical Autism Spectrum Disorder (ASD representing the extreme end of this distribution. Inherent in this proposal is that biological mechanisms associated with clinical ASD may also underpin variation in autistic-like traits within the general population. A genome-wide association study using 2,462,046 single nucleotide polymorphisms (SNPs was undertaken for ASD in 965 individuals from the Western Australian Pregnancy Cohort (Raine Study. No SNP associations reached genome-wide significance (p < 5.0 x 10-8. However, investigations into nominal observed SNP associations (p < 1.0 x 10-5 add support to two positional candidate genes previously implicated in ASD aetiology, PRKCB1 and CBLN1.The rs198198 SNP (p = 9.587 x 10-6, is located within an intron of the protein kinase C, beta 1 (PRKCB1 gene on chromosome 16p11. The PRKCB1 gene has been previously reported in linkage and association studies for ASD, and its mRNA expression has been shown to be significantly down regulated in ASD cases compared with controls. The rs16946931 SNP (p = 1.78 x 10-6 is located in a region flanking the Cerebellin 1 (CBLN1 gene on chromosome 16q12.1. The CBLN1 gene is involved with synaptogenesis and is part of a gene family previously implicated in ASD. This GWA study is only the second to examine SNPs associated with autistic-like traits in the general population, and provides evidence to support roles for the PRKCB1 and CBLN1 genes in risk of clinical ASD.

MetaGenyo: a web tool for meta-analysis of genetic association studies.

Science.gov (United States)

Martorell-Marugan, Jordi; Toro-Dominguez, Daniel; Alarcon-Riquelme, Marta E; Carmona-Saez, Pedro

2017-12-16

Genetic association studies (GAS) aims to evaluate the association between genetic variants and phenotypes. In the last few years, the number of this type of study has increased exponentially, but the results are not always reproducible due to experimental designs, low sample sizes and other methodological errors. In this field, meta-analysis techniques are becoming very popular tools to combine results across studies to increase statistical power and to resolve discrepancies in genetic association studies. A meta-analysis summarizes research findings, increases statistical power and enables the identification of genuine associations between genotypes and phenotypes. Meta-analysis techniques are increasingly used in GAS, but it is also increasing the amount of published meta-analysis containing different errors. Although there are several software packages that implement meta-analysis, none of them are specifically designed for genetic association studies and in most cases their use requires advanced programming or scripting expertise. We have developed MetaGenyo, a web tool for meta-analysis in GAS. MetaGenyo implements a complete and comprehensive workflow that can be executed in an easy-to-use environment without programming knowledge. MetaGenyo has been developed to guide users through the main steps of a GAS meta-analysis, covering Hardy-Weinberg test, statistical association for different genetic models, analysis of heterogeneity, testing for publication bias, subgroup analysis and robustness testing of the results. MetaGenyo is a useful tool to conduct comprehensive genetic association meta-analysis. The application is freely available at http://bioinfo.genyo.es/metagenyo/ .

On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.

Directory of Open Access Journals (Sweden)

Sungho Won

2009-11-01

Full Text Available For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, it maintains the same robustness against population admixture as traditional family-based approaches that are based exclusively on the within-family information. The approach is suitable for the analysis of almost any trait type, e.g. binary, continuous, time-to-onset, multivariate, etc., and combinations of those. We use simulation studies to verify all theoretically derived properties of the approach, estimate its power, and compare it with other standard approaches. We illustrate the practical implications of the new analysis method by an application to a lung-function phenotype, forced expiratory volume in one second (FEV1 in 4 genome-wide association studies.

Genome-wide association study of retinopathy in individuals without diabetes.

Directory of Open Access Journals (Sweden)

Richard A Jensen

Full Text Available Mild retinopathy (microaneurysms or dot-blot hemorrhages is observed in persons without diabetes or hypertension and may reflect microvascular disease in other organs. We conducted a genome-wide association study (GWAS of mild retinopathy in persons without diabetes.A working group agreed on phenotype harmonization, covariate selection and analytic plans for within-cohort GWAS. An inverse-variance weighted fixed effects meta-analysis was performed with GWAS results from six cohorts of 19,411 Caucasians. The primary analysis included individuals without diabetes and secondary analyses were stratified by hypertension status. We also singled out the results from single nucleotide polymorphisms (SNPs previously shown to be associated with diabetes and hypertension, the two most common causes of retinopathy.No SNPs reached genome-wide significance in the primary analysis or the secondary analysis of participants with hypertension. SNP, rs12155400, in the histone deacetylase 9 gene (HDAC9 on chromosome 7, was associated with retinopathy in analysis of participants without hypertension, -1.3±0.23 (beta ± standard error, p = 6.6×10(-9. Evidence suggests this was a false positive finding. The minor allele frequency was low (∼2%, the quality of the imputation was moderate (r(2 ∼0.7, and no other common variants in the HDAC9 gene were associated with the outcome. SNPs found to be associated with diabetes and hypertension in other GWAS were not associated with retinopathy in persons without diabetes or in subgroups with or without hypertension.This GWAS of retinopathy in individuals without diabetes showed little evidence of genetic associations. Further studies are needed to identify genes associated with these signs in order to help unravel novel pathways and determinants of microvascular diseases.

Intent inferencing by an intelligent operator's associate - A validation study

Science.gov (United States)

Jones, Patricia M.

1988-01-01

In the supervisory control of a complex, dynamic system, one potential form of aiding for the human operator is a computer-based operator's associate. The design philosophy of the operator's associate is that of 'amplifying' rather than automating human skills. In particular, the associate possesses understanding and control properties. Understanding allows it to infer operator intentions and thus form the basis for context-dependent advice and reminders; control properties allow the human operator to dynamically delegate individual tasks or subfunctions to the associate. This paper focuses on the design, implementation, and validation of the intent inferencing function. Two validation studies are described which empirically demonstrate the viability of the proposed approach to intent inferencing.

Genome-wide association studies of obesity and metabolic syndrome.

Science.gov (United States)

Fall, Tove; Ingelsson, Erik

2014-01-25

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were largely unknown, with the exception of a few forms of monogenic extreme obesity. Since genome-wide association studies (GWAS) became available, large advances have been made. The first single nucleotide polymorphism robustly associated with increased body mass index (BMI) was in 2007 mapped to a gene with for the time unknown function. This gene, now known as fat mass and obesity associated (FTO) has been repeatedly replicated in several ethnicities and is affecting obesity by regulating appetite. Since the first report from a GWAS of obesity, an increasing number of markers have been shown to be associated with BMI, other measures of obesity or fat distribution and metabolic syndrome. This systematic review of obesity GWAS will summarize genome-wide significant findings for obesity and metabolic syndrome and briefly give a few suggestions of what is to be expected in the next few years. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Genome-Wide Association Study for Nine Plant Architecture Traits in Sorghum

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Jing Zhao

2016-07-01

Full Text Available Sorghum [ (L Moench], an important grain and forage crop, is receiving significant attention as a lignocellulosic feedstock because of its water-use efficiency and high biomass yield potential. Because of the advancement of genotyping and sequencing technologies, genome-wide association study (GWAS has become a routinely used method to investigate the genetic mechanisms underlying natural phenotypic variation. In this study, we performed a GWAS for nine grain and biomass-related plant architecture traits to determine their overall genetic architecture and the specific association of allelic variants in gibberellin (GA biosynthesis and signaling genes with these phenotypes. A total of 101 single-nucleotide polymorphism (SNP representative regions were associated with at least one of the nine traits, and two of the significant markers correspond to GA candidate genes, ( and (, affecting plant height and seed number, respectively. The resolution of a previously reported quantitative trait loci (QTL for leaf angle on chromosome 7 was increased to a 1.67 Mb region containing seven candidate genes with good prospects for further investigation. This study provides new knowledge of the association of GA genes with plant architecture traits and the genomic regions controlling variation in leaf angle, stem circumference, internode number, tiller number, seed number, panicle exsertion, and panicle length. The GA gene affecting seed number variation ( and the genomic region on chromosome 7 associated with variation in leaf angle are also important outcomes of this study and represent the foundation of future validation studies needed to apply this knowledge in breeding programs.

"Městské legendy" na pomezí oborů: antropologický, folkloristický nebo sociologický diskurs?

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Petr Janeček

2009-04-01

Full Text Available Theoretical approach to contemporary oral narratives such as „urban legends“, rumour or gossip has been always afflicted by artifical gaps between various academical fields, most notably between social sciences (social anthropology, sociology and humanities (folkloristics, literary science. Presented article briefly sumarizes some of the most interesting main theories - but also defficiences - of contemporary folklore studies in fields of folkloristics, literary theory, social antropology and sociology, and calls for multidisciplinary analysis of this phenomenon.

Known glioma risk loci are associated with glioma with a family history of brain tumours -- a case-control gene association study.

Science.gov (United States)

Melin, Beatrice; Dahlin, Anna M; Andersson, Ulrika; Wang, Zhaoming; Henriksson, Roger; Hallmans, Göran; Bondy, Melissa L; Johansen, Christoffer; Feychting, Maria; Ahlbom, Anders; Kitahara, Cari M; Wang, Sophia S; Ruder, Avima M; Carreón, Tania; Butler, Mary Ann; Inskip, Peter D; Purdue, Mark; Hsing, Ann W; Mechanic, Leah; Gillanders, Elizabeth; Yeager, Meredith; Linet, Martha; Chanock, Stephen J; Hartge, Patricia; Rajaraman, Preetha

2013-05-15

Familial cancer can be used to leverage genetic association studies. Recent genome-wide association studies have reported independent associations between seven single nucleotide polymorphisms (SNPs) and risk of glioma. The aim of this study was to investigate whether glioma cases with a positive family history of brain tumours, defined as having at least one first- or second-degree relative with a history of brain tumour, are associated with known glioma risk loci. One thousand four hundred and thirty-one glioma cases and 2,868 cancer-free controls were identified from four case-control studies and two prospective cohorts from USA, Sweden and Denmark and genotyped for seven SNPs previously reported to be associated with glioma risk in case-control designed studies. Odds ratios were calculated by unconditional logistic regression. In analyses including glioma cases with a family history of brain tumours (n = 104) and control subjects free of glioma at baseline, three of seven SNPs were associated with glioma risk: rs2736100 (5p15.33, TERT), rs4977756 (9p21.3, CDKN2A-CDKN2B) and rs6010620 (20q13.33, RTEL1). After Bonferroni correction for multiple comparisons, only one marker was statistically significantly associated with glioma risk, rs6010620 (ORtrend for the minor (A) allele, 0.39; 95% CI: 0.25-0.61; Bonferroni adjusted ptrend , 1.7 × 10(-4) ). In conclusion, as previously shown for glioma regardless of family history of brain tumours, rs6010620 (RTEL1) was associated with an increased risk of glioma when restricting to cases with family history of brain tumours. These findings require confirmation in further studies with a larger number of glioma cases with a family history of brain tumours. Copyright © 2012 UICC.

An association study of suicide and candidate genes in the serotonergic system

DEFF Research Database (Denmark)

Buttenschøn, Henriette N; Flint, Tracey J; Foldager, Leslie

2013-01-01

Introduction: Strong evidence demonstrates a genetic susceptibility to suicidal behaviour and a relationship between suicide and mental disorders. The aim of this study was to test for association between suicide and five selected genetic variants, which had shown association with suicide in other...... populations. Method: We performed a nationwide case-control study on all suicide cases sent for autopsy in Denmark between the years 2000 and 2007. The study comprised 572 cases and 1049 controls and is one of the largest genetic studies in completed suicide to date. The analysed markers were located within...... the Serotonin Transporter (SLC6A4), Monoamine Oxidase-A (MAOA) and the Ttyptophan Hydroxylase I and II (TPH1 and TPH2) genes. Results: None of the genetic markers within SLC6A4, MAOA, TPH1 and TPH2 were significantly associated with completed suicide or suicide method in the basic association tests. Exploratory...

Genome-wide association study identifies a novel canine glaucoma locus.

Directory of Open Access Journals (Sweden)

Saija J Ahonen

Full Text Available Glaucoma is an optic neuropathy and one of the leading causes of blindness. Its hereditary forms are classified into primary closed-angle (PCAG, primary open-angle (POAG and primary congenital glaucoma (PCG. Although many loci have been mapped in human, only a few genes have been identified that are associated with the development of glaucoma and the genetic basis of the disease remains poorly understood. Glaucoma has also been described in many dog breeds, including Dandie Dinmont Terriers (DDT in which it is a late-onset (>7 years disease. We designed clinical and genetic studies to better define the clinical features of glaucoma in the DDT and to identify the genetic cause. Clinical diagnosis was based on ophthalmic examinations of the affected dogs and 18 additionally investigated unaffected DDTs. We collected DNA from over 400 DTTs and a genome wide association study was performed in a cohort of 23 affected and 23 controls, followed by a fine mapping, a replication study and candidate gene sequencing. The clinical study suggested that ocular abnormalities including abnormal iridocorneal angles and pectinate ligament dysplasia are common (50% and 72%, respectively in the breed and the disease resembles human PCAG. The genetic study identified a novel 9.5 Mb locus on canine chromosome 8 including the 1.6 Mb best associated region (p = 1.63 × 10(-10, OR = 32 for homozygosity. Mutation screening in five candidate genes did not reveal any causative variants. This study indicates that although ocular abnormalities are common in DDTs, the genetic risk for glaucoma is conferred by a novel locus on CFA8. The canine locus shares synteny to a region in human chromosome 14q, which harbors several loci associated with POAG and PCG. Our study reveals a new locus for canine glaucoma and ongoing molecular studies will likely help to understand the genetic etiology of the disease.

Association study between schizophrenia and dopamine D3 receptor gene polymorphism

Energy Technology Data Exchange (ETDEWEB)

Tanaka, Toshihisa; Takahashi, Makoto; Maeda, Masaya [Niigata Univ. (Japan)] [and others

1996-07-26

Crocq et al. reported the existence of an association between schizophrenia and homozygosity of a BalI polymorphism in the first exon of the dopamine D3 receptor (DRD3) gene. In response to this report, further studies were conducted; however, these studies yielded conflicting results. In the present study, we examined 100 unrelated Japanese schizophrenics and 100 normal controls to determine any association between this polymorphism and schizophrenia. Results suggest that neither allele nor genotype frequencies of the DRD3 gene in the schizophrenics as a whole are significantly different from those of the controls. Further, we found no association between any allele or genotype and any clinical subtype based on family history of schizophrenia and age-at-onset. A significantly high frequency of homozygosity of a dopamine D3 receptor gene allele was not observed in the schizophrenics as a whole, or in clinical subtypes. Our results suggest that an association between the dopamine D3 receptor gene and schizophrenia is unlikely to exist. 26 refs., 1 tab.

A Pooled Genome-Wide Association Study of Asperger Syndrome.

Directory of Open Access Journals (Sweden)

Varun Warrier

Full Text Available Asperger Syndrome (AS is a neurodevelopmental condition characterized by impairments in social interaction and communication, alongside the presence of unusually repetitive, restricted interests and stereotyped behaviour. Individuals with AS have no delay in cognitive and language development. It is a subset of Autism Spectrum Conditions (ASC, which are highly heritable and has a population prevalence of approximately 1%. Few studies have investigated the genetic basis of AS. To address this gap in the literature, we performed a genome-wide pooled DNA association study to identify candidate loci in 612 individuals (294 cases and 318 controls of Caucasian ancestry, using the Affymetrix GeneChip Human Mapping version 6.0 array. We identified 11 SNPs that had a p-value below 1x10-5. These SNPs were independently genotyped in the same sample. Three of the SNPs (rs1268055, rs7785891 and rs2782448 were nominally significant, though none remained significant after Bonferroni correction. Two of our top three SNPs (rs7785891 and rs2782448 lie in loci previously implicated in ASC. However, investigation of the three SNPs in the ASC genome-wide association dataset from the Psychiatric Genomics Consortium indicated that these three SNPs were not significantly associated with ASC. The effect sizes of the variants were modest, indicating that our study was not sufficiently powered to identify causal variants with precision.

Challenges in reproducibility of genetic association studies: lessons learned from the obesity field.

Science.gov (United States)

Li, A; Meyre, D

2013-04-01

A robust replication of initial genetic association findings has proved to be difficult in human complex diseases and more specifically in the obesity field. An obvious cause of non-replication in genetic association studies is the initial report of a false positive result, which can be explained by a non-heritable phenotype, insufficient sample size, improper correction for multiple testing, population stratification, technical biases, insufficient quality control or inappropriate statistical analyses. Replication may, however, be challenging even when the original study describes a true positive association. The reasons include underpowered replication samples, gene × gene, gene × environment interactions, genetic and phenotypic heterogeneity and subjective interpretation of data. In this review, we address classic pitfalls in genetic association studies and provide guidelines for proper discovery and replication genetic association studies with a specific focus on obesity.

The cross-national pattern of happiness. Test of predictions implied in three theories of happiness

NARCIS (Netherlands)

R. Veenhoven (Ruut); J.J. Ehrhardt (Joop)

1995-01-01

textabstractABSTRACT. Predictions about level and dispersion of happiness in nations are derived from three theories of happiness: comparison-theory, folklore-theory and livability-theory. The predictions are tested on two cross national data-sets: a comparative survey among university students in

International Journal of Health Research

African Journals Online (AJOL)

Erah

... of F. aestuans possess gatroprotective properties could justify folklore uses of the plant in ... guinea pigs (250-300 g) and rabbits (1.5-2.0 ... material. The leaves of F. aestuans were collected from Nsukka, Enugu State, Nigeria in the month of ...

401-IJBCS-Article-Thushari Bandara

African Journals Online (AJOL)

DR GATSING

in type 2 diabetic rats. Fasting blood sugar (FBS) levels of the diabetic rats reduced significantly (p=0.001) ... There is a folkloric history among the people in Jaffna, Sri Lanka, ... (5%), fish meal (10%), oil cake (10%), gram. (3.9%), pulses ...

Integration in sight?

NARCIS (Netherlands)

Willem Huijnk; Iris Andriessen

2016-01-01

Orininal title: Integratie in zicht? Migration and integration top the list of social problems which worry people in the Netherlands the most. Radicalisation, the controversy surrounding the folklore figure Zwarte Piet (‘Black Pete’), the refugee crisis and ethnic profiling are just a

FROM 'FOLKISM' TO PERFORMANCE: A NEW SCENIC STRATEGY ...

African Journals Online (AJOL)

process that exist between the actors and audience. Keywords: Folkism, Audience integration, Akpakaland, Nigerian folkloric performance. Introduction. There have been a lot of controversies about finding a comprehensive theatrical principle to define and integrate Nigerian audience into performances over the past few ...

In-vitro antimicrobial activity of crude extracts of Diospyros ...

African Journals Online (AJOL)

Diospyros species in folklore medicine are used as anti-inflammatory, antibacterial, antioxidant, anticancer and antiviral agents. The in vitro antimicrobial activity of crude extracts of the leaves of Diospyros monbuttensis were evaluated against three bacterial species (Staphylococcus aureus, Escherichia coli and ...

Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study

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Sanjeevan Sriskandarajah

2017-01-01

Full Text Available Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives. To quantify the cancer risk associated with contemporary cyclophosphamide-sparing protocols. Methods. Patients from the Norwegian Kidney Biopsy Registry between 1988 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody (ANCA serology were included. Standardised incidence ratios (SIRs were calculated to compare the study cohort with the general population. Results. The study cohort included 419 patients. During 3010 person-years, cancer developed in 41 patients (9.79%; the expected number of cancer cases was 37.5 (8.95%. The cohort had SIRs as follows: 1.09, all cancer types (95% CI, 0.81 to 1.49; 0.96, all types except nonmelanoma skin cancer (95% CI, 0.69 to 1.34; 3.40, nonmelanoma skin cancer (95% CI, 1.62 to 7.14; 3.52, hematologic cancer (95% CI, 1.32 to 9.37; 2.12, posttransplant cancer (95% CI, 1.01 to 4.44; and 1.53, during the 1–5-year follow-up after diagnosis (95% CI, 1.01 to 2.32. Conclusions. Cancer risk did not increase significantly in this cohort with ANCA-associated glomerulonephritis. However, increased risk of nonmelanoma skin cancer, posttransplant cancer, and hematologic cancer indicates an association between immunosuppression and malignancy.

Association between asthma and dysphonia: A population-based study.

Science.gov (United States)

Park, Bumjung; Choi, Hyo Geun

2016-09-01

We investigated whether asthma predisposes patients to organic laryngeal lesions or increases dysphonia in those without organic laryngeal lesions. We performed a cross-sectional study with data from the Korea National Health and Nutrition Examination Survey; 19,330 subjects from 2008 through 2011 were included. The associations of asthma with organic laryngeal lesions and dysphonia were analyzed using a simple/multiple logistic regression analysis with complex sampling while adjusting for confounding factors (age, sex, smoking status, stress level, and body mass index) that could contribute to dysphonia. Compared with non-asthma participants, the asthma patients tended to be older and female and to have higher stress levels. These factors were associated with dysphonia (Age, AOR = 1.20, 95% CI = 1.14 = 1.23, P dysphonia. Compared with non-asthma participants, asthma patients who had not taken asthma medication recently showed a higher AOR (1.62; 95% CI = 1.0-2.42) for dysphonia, and asthma patients who had taken asthma medication recently showed the highest adjusted odds ratio for dysphonia (AOR = 1.97; 95% confidence interval, CI = 1.28-3.02, P = 0.001). On multiple logistic regression analysis, vocal nodules, laryngeal polyps, and laryngitis were not associated with asthma (all P > 0.05). Asthma patients are predisposed to subjective dysphonia due to demographic and clinical characteristics (older age, female, and higher stress level) as well as to asthma itself. However, asthma was not associated with organic laryngeal lesions in this study.

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.

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Sandosh Padmanabhan

2010-10-01

Full Text Available Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conducted a genome-wide association study in 1,621 hypertensive cases and 1,699 controls and follow-up validation analyses in 19,845 cases and 16,541 controls using an extreme case-control design. We identified a locus on chromosome 16 in the 5' region of Uromodulin (UMOD; rs13333226, combined P value of 3.6 × 10⁻¹¹. The minor G allele is associated with a lower risk of hypertension (OR [95%CI]: 0.87 [0.84-0.91], reduced urinary uromodulin excretion, better renal function; and each copy of the G allele is associated with a 7.7% reduction in risk of CVD events after adjusting for age, sex, BMI, and smoking status (H.R. = 0.923, 95% CI 0.860-0.991; p = 0.027. In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83-0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83-0.96], p = 0.003. In clinical functional studies, we also consistently show the minor G allele is associated with lower urinary uromodulin excretion. The exclusive expression of uromodulin in the thick portion of the ascending limb of Henle suggests a putative role of this variant in hypertension through an effect on sodium homeostasis. The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.

Genome-wide association study for milking speed in French Holstein cows

DEFF Research Database (Denmark)

Marete, Andrew Gitahi; Sahana, Goutam; Fritz, Sebastian

2018-01-01

Using a combination of data from the BovineSNP50 BeadChip SNP array (Illumina, San Diego, CA) and a EuroGenomics (Amsterdam, the Netherlands) custom single nucleotide polymorphism (SNP) chip with SNP pre-selected from whole genome sequence data, we carried out an association study of milking speed...... associated with milking speed. As clinical mastitis and somatic cell score have an unfavorable genetic correlation with milking speed, we tested whether the most significant SNP on these 22 chromosomes associated with milking speed were also associated with clinical mastitis or somatic cell score. Nine...... hundred seventy-one genome-wide significant SNP were associated with milking speed. Of these, 86 were associated with clinical mastitis and 198 with somatic cell score. The most significant association signals for milking speed were observed on chromosomes 7, 8, 10, 14, and 18. The most significant signal...

I La Galigo Folklore Illustration on Textile Media

Directory of Open Access Journals (Sweden)

Yosepin Sri Ningsih

2014-01-01

Full Text Available This project was an effort in conserving the I La Galigo epic story while at the same time adding value to silk, the famous textile product from South Sulawesi and the origin of I La Galigo. As a work of literature, I La Galigo is categorized as an epic. It is known locally as Sureq Galigo in Bugis. It is divided in a number of episodes or tereng. The most well-known tereng is the one which describes the relationship between Sawerigading and a princess called I We Cudai. From that relationship I La Galigo, the central character of this epic is born. For this project six of the most well-known episodes were selected because of the amount of available supporting data, both theoretical and visual. The selected episodes were translated from their original narrative form into visual language or images. The illustration technique used in this project was STP (Space Time Plane. With this technique every object is drawn from varying viewpoints in one frame, both in space and time. Hand embroidery was added to the painted images. The silk painting can be used as an interior element with value added by the I La Galigo illustrations. Keywords: I La Galigo; epic; Sulawesi; illustration; silk painting; space time plane.

Folklore in bureaucracy code: Running a music event

Directory of Open Access Journals (Sweden)

Krstanović-Lukić Miroslava

2004-01-01

Full Text Available A music folk-created piece of work is a construction expressed as a paradigm part of a set in the bureaucracy system and the public arena. Such a work is a mechanical concept, which defines inheritance as a construction of authenticity saturated with elements of folk, national culture. It is also a subject of certain conventions in the system of regulations; namely, it is a part of the administrative code. The usage of the folk created work as a paradigm and legislations is realized through an organizational apparatus that is, it becomes entertainment, a spectacle. This paper analyzes the functioning of the organizational machinery of a folk spectacle, starting with the government authorities, local self-management and the spectacle's administrative committees. To illustrate this phenomenon, the paper presents the development of a trumpet playing festival in Dragačevo. This particular festival establishes a cultural, economic and political order with a clear and defined division of power. The analysis shows that the folk event in question, through its programs and activities, represents a scene and arena of individual and group interests. Organizational interactions are recognized in binary oppositions: sovereignty/dependency official/unofficial, dominancy/ subordination, innovative/inherited common/different, needed/useful, original/copy, one's own/belonging to someone else.

IMAGE OF »THE TURK« IN SLOVENE FOLKLORE

OpenAIRE

Anja Mlakar

2015-01-01

Legends about the time of the Turkish raids form an important and substantial part of the Slovene oral traditions. A closer examination of their content reveals a mixture of mythologized historical events from the time of the Turkish raids that are preserved in the Slovene collective memory (thou influenced by different ideological agendas), elements that are in their core mythological and use the time of the Turkish raids more or less as a chronological frame, and elements that ex-press the ...

Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution.

Science.gov (United States)

Boueiz, Adel; Lutz, Sharon M; Cho, Michael H; Hersh, Craig P; Bowler, Russell P; Washko, George R; Halper-Stromberg, Eitan; Bakke, Per; Gulsvik, Amund; Laird, Nan M; Beaty, Terri H; Coxson, Harvey O; Crapo, James D; Silverman, Edwin K; Castaldi, Peter J; DeMeo, Dawn L

2017-03-15

Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout the lungs. Upper lobe-predominant emphysema has emerged as an important predictor of response to lung volume reduction surgery. Yet, aside from alpha-1 antitrypsin deficiency, the genetic determinants of emphysema distribution remain largely unknown. To identify the genetic influences of emphysema distribution in non-alpha-1 antitrypsin-deficient smokers. A total of 11,532 subjects with complete genotype and computed tomography densitometry data in the COPDGene (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease [COPD]; non-Hispanic white and African American), ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints), and GenKOLS (Genetics of Chronic Obstructive Lung Disease) studies were analyzed. Two computed tomography scan emphysema distribution measures (difference between upper-third and lower-third emphysema; ratio of upper-third to lower-third emphysema) were tested for genetic associations in all study subjects. Separate analyses in each study population were followed by a fixed effect metaanalysis. Single-nucleotide polymorphism-, gene-, and pathway-based approaches were used. In silico functional evaluation was also performed. We identified five loci associated with emphysema distribution at genome-wide significance. These loci included two previously reported associations with COPD susceptibility (4q31 near HHIP and 15q25 near CHRNA5) and three new associations near SOWAHB, TRAPPC9, and KIAA1462. Gene set analysis and in silico functional evaluation revealed pathways and cell types that may potentially contribute to the pathogenesis of emphysema distribution. This multicohort genome-wide association study identified new genomic loci associated with differential emphysematous destruction throughout the lungs. These findings may point to new biologic pathways on which to expand diagnostic and therapeutic

Detecting rare variants in case-parents association studies.

Directory of Open Access Journals (Sweden)

Kuang-Fu Cheng

Full Text Available Despite the success of genome-wide association studies (GWASs in detecting common variants (minor allele frequency ≥0.05 many suggested that rare variants also contribute to the genetic architecture of diseases. Recently, researchers demonstrated that rare variants can show a strong stratification which may not be corrected by using existing methods. In this paper, we focus on a case-parents study and consider methods for testing group-wise association between multiple rare (and common variants in a gene region and a disease. All tests depend on the numbers of transmitted mutant alleles from parents to their diseased children across variants and hence they are robust to the effect of population stratification. We use extensive simulation studies to compare the performance of four competing tests: the largest single-variant transmission disequilibrium test (TDT, multivariable test, combined TDT, and a likelihood ratio test based on a random-effects model. We find that the likelihood ratio test is most powerful in a wide range of settings and there is no negative impact to its power performance when common variants are also included in the analysis. If deleterious and protective variants are simultaneously analyzed, the likelihood ratio test was generally insensitive to the effect directionality, unless the effects are extremely inconsistent in one direction.

[Associated costs with dental studies in a public Mexican university].

Science.gov (United States)

Medina-Solís, Carlo Eduardo; Medina-Solís, June Janette; Sánchez-de la Cruz, Alicia; Ascencio-Villagrán, Arturo; de la Rosa-Santillana, Rubén; Mendoza-Rodríguez, Martha; Maupomé, Gerardo

2014-01-01

To calculate associated costs with dental studies (ACDS) in a public university. We performed a cross-sectional study using a costing system on a random sample of 376 dental students enrolled at any semester in a public university. To calculate ACDS (Mexican pesos of 2009-1), we used a questionnaire divided into eight sections. Sociodemographic and socioeconomic variables, housing costs, food, transportation, instruments and equipment, as well as remunerations associated with patient care along 16 weeks of classes in each semester were included. We used linear regression. The average of ACDS was of 18,357.54 ± 12,746.81 Mexican pesos. The largest percentage of ACDS (30.2 %) was for clinical instruments (5,537.66 ± 6,260.50). Students also spent funds in paying to patients for their time during care delivered (2,402.11 ± 4,796.50). Associated variables (p 〈 0.001) with the ACDS were having completed at least one clinical course or one theoretical-practical course, living within the state or out of state (compared to students who live in the city where dental studies take place), and being enrolled in the more advanced dental studies. The results indicate that a significant percentage of the cost to students (13.1 %) is related with clinical care delivery.

Impact of associated injuries in the Floating knee: A retrospective study

Science.gov (United States)

Rethnam, Ulfin; Yesupalan, Rajam S; Nair, Rajagopalan

2009-01-01

Background Floating knee injuries are usually associated with other significant injuries. Do these injuries have implications on the management of the floating knee and the final outcome of patients? Our study aims to assess the implications of associated injuries in the management and final outcome of floating knee. Methods 29 patients with floating knees were assessed in our institution. A retrospective analysis of medical records and radiographs were done and all associated injuries were identified. The impact of associated injuries on delay in initial surgical management, delay in rehabilitation & final outcome of the floating knee were assessed. Results 38 associated injuries were noted. 7 were associated with ipsilateral knee injuries. Lower limb injuries were most commonly associated with the floating knee. Patients with some associated injuries had a delay in surgical management and others a delay in post-operative rehabilitation. Knee ligament and vascular injuries were associated with poor outcome. Conclusion The associated injuries were quite frequent with the floating knee. Some of the associated injuries caused a delay in surgical management and post-operative rehabilitation. In assessment of the final outcome, patients with associated knee and vascular injuries had a poor prognosis. Majority of the patients with associated injuries had a good or excellent outcome. PMID:19144197

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature

Directory of Open Access Journals (Sweden)

Frackelton Edward C

2010-06-01

Full Text Available Abstract Background Human height is considered highly heritable and correlated with certain disorders, such as type 2 diabetes and cancer. Despite environmental influences, genetic factors are known to play an important role in stature determination. A number of genetic determinants of adult height have already been established through genome wide association studies. Methods To examine 51 single nucleotide polymorphisms (SNPs corresponding to the 46 previously reported genomic loci for height in 8,184 European American children with height measurements. We leveraged genotyping data from our ongoing GWA study of height variation in children in order to query the 51 SNPs in this pediatric cohort. Results Sixteen of these SNPs yielded at least nominally significant association to height, representing fifteen different loci including EFEMP1-PNPT1, GPR126, C6orf173, SPAG17, Histone class 1, HLA class III and GDF5-UQCC. Other loci revealed no evidence for association, including HMGA1 and HMGA2. For the 16 associated variants, the genotype score explained 1.64% of the total variation for height z-score. Conclusion Among 46 loci that have been reported to associate with adult height to date, at least 15 also contribute to the determination of height in childhood.

Psychosocial risk factors associated with cyberbullying among adolescents: a population-based study.

Science.gov (United States)

Sourander, Andre; Brunstein Klomek, Anat; Ikonen, Maria; Lindroos, Jarna; Luntamo, Terhi; Koskelainen, Merja; Ristkari, Terja; Helenius, Hans

2010-07-01

To our knowledge, no population study examining psychosocial and psychiatric risk factors associated with cyberbullying among adolescents exists. To study cross-sectional associations between cyberbullying and psychiatric and psychosomatic problems among adolescents. Population-based cross-sectional study. Finland. The sample consists of 2215 Finnish adolescents aged 13 to 16 years with complete information about cyberbullying and cybervictimization. Self-reports of cyberbullying and cybervictimization during the past 6 months. In the total sample, 4.8% were cybervictims only, 7.4% were cyberbullies only, and 5.4% were cyberbully-victims. Cybervictim-only status was associated with living in a family with other than 2 biological parents, perceived difficulties, emotional and peer problems, headache, recurrent abdominal pain, sleeping difficulties, and not feeling safe at school. Cyberbully-only status was associated with perceived difficulties, hyperactivity, conduct problems, low prosocial behavior, frequent smoking and drunkenness, headache, and not feeling safe at school. Cyberbully-victim status was associated with all of these risk factors. Among cybervictims, being cyberbullied by a same-sex or opposite-sex adult, by an unknown person, and by a group of people were associated with fear for safety, indicating possible trauma. Both cyberbullying and cybervictimization are associated with psychiatric and psychosomatic problems. The most troubled are those who are both cyberbullies and cybervictims. This indicates the need for new strategies for cyberbullying prevention and intervention.

Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting

NARCIS (Netherlands)

Slof-Op 't Landt, M. C. T.; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C. M.; Houwing-Duistermaat, J. J.; van Trier, J.; Onkenhout, E. J.; Vink, J. M.; van Beijsterveldt, C. E. M.; Brandys, M. K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; de Zwaan, M.; Herpertz, S.; Ehrlich, S.; van Elburg, A. A.; Adan, R. A. H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D. I.; van Furth, E. F.; Slagboom, P. E.

2011-01-01

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of

Association study in eating disorders: TPH2 associates with anorexia nervosa and self induced vomiting

NARCIS (Netherlands)

Slof-Op 't Landt, M.C.T.; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C.M.; Houwing-Duistermaat, J.J.; van Trier, J.; Onkenhout, E.J.; Vink, J.M.; van Beijsterveldt, C.E.M.; Brandys, M.K.; Sanders, N.; Zipfel, S.; Herzog, W.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; Zwaan, M.; Herpertz, S.; Ehrlich, S.; van Elburg, A.A.; Adan, R.A.H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D.I.; van Furth, E.F.; Slagboom, P.E.

2011-01-01

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of

Association study in eating disorders : TPH2 associates with anorexia nervosa and self-induced vomiting

NARCIS (Netherlands)

't Landt, M. C. T. Slof-Op; Meulenbelt, I.; Bartels, M.; Suchiman, E.; Middeldorp, C. M.; Houwing-Duistermaat, J. J.; van Trier, J.; Onkenhout, E. J.; Vink, J. M.; van Beijsterveldt, C. E. M.; Brandys, M. K.; Sanders, N.; Zipfel, S.; Herpertz-Dahlmann, B.; Klampfl, K.; Fleischhaker, C.; Zeeck, A.; de Zwaan, M.; Herpertz, S.; Ehrlich, S.; van Elburg, A. A.; Adan, R. A. H.; Scherag, S.; Hinney, A.; Hebebrand, J.; Boomsma, D. I.; van Furth, E. F.; Slagboom, P. E.; Herzog, W.

Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of

Toward a Generative Model of Legend: Pizzas, Bridges, Vaccines, and Witches

Directory of Open Access Journals (Sweden)

Timothy R. Tangherlini

2017-12-01

Full Text Available We propose a generative model of the legend. The model is elaborated based on two case studies, the first of contemporary storytelling related to vaccination on parenting blogs, and the second of historical storytelling related to witchcraft and folk healing in nineteenth century Denmark. The model reveals the interdependent levels of the multiscale model, solving a problem of poor fit related to many two level models of folklore genre structure. The model supports the study of rumor, and the dynamics of storytelling, including the hyperactive transmission state of “viral” stories.

Sniffing out significant "Pee values": genome wide association study of asparagus anosmia.

Science.gov (United States)

Markt, Sarah C; Nuttall, Elizabeth; Turman, Constance; Sinnott, Jennifer; Rimm, Eric B; Ecsedy, Ethan; Unger, Robert H; Fall, Katja; Finn, Stephen; Jensen, Majken K; Rider, Jennifer R; Kraft, Peter; Mucci, Lorelei A

2016-12-13

 To determine the inherited factors associated with the ability to smell asparagus metabolites in urine.  Genome wide association study.  Nurses' Health Study and Health Professionals Follow-up Study cohorts.  6909 men and women of European-American descent with available genetic data from genome wide association studies.  Participants were characterized as asparagus smellers if they strongly agreed with the prompt "after eating asparagus, you notice a strong characteristic odor in your urine," and anosmic if otherwise. We calculated per-allele estimates of asparagus anosmia for about nine million single nucleotide polymorphisms using logistic regression. P values asparagus anosmia, all in a region on chromosome 1 (1q44: 248139851-248595299) containing multiple genes in the olfactory receptor 2 (OR2) family. Conditional analyses revealed three independent markers associated with asparagus anosmia: rs13373863, rs71538191, and rs6689553.  A large proportion of people have asparagus anosmia. Genetic variation near multiple olfactory receptor genes is associated with the ability of an individual to smell the metabolites of asparagus in urine. Future replication studies are necessary before considering targeted therapies to help anosmic people discover what they are missing. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Genome wide association study identifies KCNMA1 contributing to human obesity

DEFF Research Database (Denmark)

Jiao, Hong; Arner, Peter; Hoffstedt, Johan

2011-01-01

Recent genome-wide association (GWA) analyses have identified common single nucleotide polymorphisms (SNPs) that are associated with obesity. However, the reported genetic variation in obesity explains only a minor fraction of the total genetic variation expected to be present in the population....... Thus many genetic variants controlling obesity remain to be identified. The aim of this study was to use GWA followed by multiple stepwise validations to identify additional genes associated with obesity....

Study of wound healing potential of Stevia rebaudiana ethanol extract in male rats

Directory of Open Access Journals (Sweden)

S. Goorani

2018-01-01

Full Text Available Background and objectives: Stevia rebaudiana has been used in medicine as anti-inflammatory, antioxidant, antipyretic, anti-fungal, and antibacterial agent. The present study was conducted to investigate the healing effects of S. rebaudiana ethanol extracts on cutaneous wounds in rats. Methods: Full-thickness excisional wounds (2×2 cm were induced on the back of 32 rats. The rats were divided into four groups as follows; untreated (control and treated with 1 mL basal cream, 1 mL S. rebaudiana ethanol extract 10%, and 1 mL tetracycline (3% for 20 days (short term. Animals of each group were euthanized at 20 day post-injury and wounds were assessed through macroscopic and microscopic analyses. Results: During the experiment, S. rebaudiana indicated a significant reduction in the wound area compared to other groups. Parameters such as arrangement of the healing tissue, re-epithelilization and epithelial formation demonstrated considerable changes when compared to the control. In addition, treatment with S. rebaudiana decreased the total number of cells, fibrocytes/fibroblasts ratio, neutrophils, and lymphocytes and enhanced the number of blood vessels and fibroblasts at 20 day. Conclusion: The present study demonstrated the wound healing activity of S. rebaudiana, lending credence to the folkloric use in the treatment of cutaneous wounds.

Sources of heterogeneity in studies of the BMI-mortality association.

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Peter, Raphael Simon; Nagel, Gabriele

2017-06-01

To date, the amount of heterogeneity among studies of the body mass index-mortality association attributable to differences in the age distribution and length of follow-up has not been quantified. Therefore, we wanted to quantify the amount of heterogeneity attributable to age and follow-up in results of studies on the body mass index-mortality relation. We used optima of the body mass index mortality association reported for 30 populations and performed meta-regression to estimate the amount of heterogeneity attributable to sex, ethnicity, mean age at baseline, percentage smokers, and length of follow-up. Ethnicity as single factor accounted for 36% (95% CI, 11-56%) of heterogeneity. Mean age and length of follow-up had an interactive effect and together accounted for 56% (95% CI, 24-74%) of the remaining heterogeneity. Sex did not significantly contribute to the heterogeneity, after controlling for ethnicity, age, and length of follow-up. A considerable amount of heterogeneity in studies of the body mass index-mortality association is attributable to ethnicity, age, and length of follow-up. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

SNPassoc: an R package to perform whole genome association studies.

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González, Juan R; Armengol, Lluís; Solé, Xavier; Guinó, Elisabet; Mercader, Josep M; Estivill, Xavier; Moreno, Víctor

2007-03-01

The popularization of large-scale genotyping projects has led to the widespread adoption of genetic association studies as the tool of choice in the search for single nucleotide polymorphisms (SNPs) underlying susceptibility to complex diseases. Although the analysis of individual SNPs is a relatively trivial task, when the number is large and multiple genetic models need to be explored it becomes necessary a tool to automate the analyses. In order to address this issue, we developed SNPassoc, an R package to carry out most common analyses in whole genome association studies. These analyses include descriptive statistics and exploratory analysis of missing values, calculation of Hardy-Weinberg equilibrium, analysis of association based on generalized linear models (either for quantitative or binary traits), and analysis of multiple SNPs (haplotype and epistasis analysis). Package SNPassoc is available at CRAN from http://cran.r-project.org. A tutorial is available on Bioinformatics online and in http://davinci.crg.es/estivill_lab/snpassoc.

Is Child Abuse Associated with Adolescent Obesity? A Population Cohort Study.

Science.gov (United States)

Hawton, Katherine; Norris, Tom; Crawley, Esther; Shield, Julian P H

Child abuse is associated with obesity in adulthood through multiple mechanisms. However, little is known about the relationship between abuse and obesity during adolescence. The aim of this study was to investigate, using a birth cohort, whether there is an association between child abuse and overweight or obesity in adolescence. This study utilizes data from the Avon Longitudinal Study of Parents and Children, a prospective cohort study based in South West England. Using data from the 4205 children with complete data at 13 and 16 years, we analyzed body mass index (BMI) and anonymous parental report of abuse. Abuse was categorized as emotional, physical, or sexual. A sub-sample of 3429 had BMI recorded at 18 years, enabling a longitudinal analysis of BMI trajectories. Using linear and logistic regression analysis, adjusting for sex and family adversity, no association was found between child abuse and BMI, BMI Z-scores, overweight, or obesity, at 13 or 16 years, with all confidence intervals straddling the null. There was weak evidence of a negative association between physical and emotional abuse and BMI trajectories between 13 and 18 years. No relationship was found between child abuse and adolescent obesity in this cohort. This challenges the assumption that adolescent obesity is linked to previous child abuse, as demonstrated for obesity in adult life. A further longitudinal study utilizing both parental and child reports with data record linkage, to improve reporting of abuse, and including neglect as an abuse category, would be desirable.

AHP 49: 高原民俗及教育研究 STUDIES OF PLATEAU FOLKLORE & EDUCATION

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AHP

2017-08-01

Full Text Available 本书是《亚洲高原视角(AHP》期刊的首次汉语翻译版，是很多有意者合作的结果，也体现了我们团队合作的力量。书中前言"AHP期刊及其鸣谢" 由才项多杰撰写（第5页）；第一章"对《拉卜楞寺》一书的评述"由Christina Kilby Robinson 著（6-9页）；第二章"豆后漏藏族村——改发与婚姻"由周毛吉, CK Stuart和Steve Frediani 著，由周毛吉译（10-48页）；第三章"循化撒拉族婚礼" 由马伟, 马建忠和CK Stuart著，由赵琳译（49-101页）；第四章"被遗弃的山神" 由立穆斯什典著，由旦箭花和尼道斯让译（102-123页）；第五章"青藏高原上的传销" 由Devin Gonier和Rgyal yum sgrol ma 著，由朵达拉译（124-144页）；第六章"青海东部农村傩祭仪式——民和土族纳顿歌" 由朱永忠和CK Stuart 著，由朱永忠译（145-158页）；第七章"民和土族祝酒歌"由朱永忠和 CK Stuart 著，由朱永忠译（159-167页）；第八章"情牵相守：三川土族库咕笳歌" 由朱永忠, 祁慧民和CK Stuart 著，由朱永忠译（168-198页）。 Abridged English Translation This is the first AHP volume in the Chinese language, containing the following articles translated from English to Chinese: 1 AHP Preface by Caixiangduojie 2 Review: Labrang Monastery by Christina Kilby Robinson 3 Stag rig Tibetan Village: Hair Changing and Marriage by 'Brug mo skyid, CK Stuart, Alexandru Anton-Luca and Steve Frediani ('Brug mo skyid, translator 4 The Xunhua Salar Wedding by Ma Wei, Ma Jianzhong, and CK Stuart (Zhao Ling, translator 5 An Abandoned Mountain Deity by Limusishiden (Dan Jianua and Nidaosirang, translators 6 Pyramid Schemes on the Tibetan Plateau by Devin Gonier and Rgyal yum sgrol ma (Duodala, translator 7 'Two Bodhisattvas From the East': Minhe Monguor Funeral Orations by Zhu Yongzhong and CK Stuart (Zhu Yongzhong, translator

Chemical constituents in n-butanol fractions of Costus afer ker Gawl leaf and stem

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Godswill Nduka Anyasor

2014-04-01

Conclusion: The bioactive compounds identified in the n-butanol fractions of C. afer leaves and stem may explain the folkloric use of C. afer plant in the treatment of chronic inflammatory and oxidative stress related diseases. [J Intercult Ethnopharmacol 2014; 3(2.000: 78-84

Genome-Wide Association Study Reveals Novel Genes Associated with Culm Cellulose Content in Bread Wheat (Triticum aestivum, L.

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Simerjeet Kaur

2017-11-01

Full Text Available Plant cell wall formation is a complex, coordinated and developmentally regulated process. Cellulose is the most dominant constituent of plant cell walls. Because of its paracrystalline structure, cellulose is the main determinant of mechanical strength of plant tissues. As the most abundant polysaccharide on earth, it is also the focus of cellulosic biofuel industry. To reduce culm lodging in wheat and for improved ethanol production, delineation of the variation for stem cellulose content could prove useful. We present results on the analysis of the stem cellulose content of 288 diverse wheat accessions and its genome-wide association study (GWAS. Cellulose concentration ranged from 35 to 52% (w/w. Cellulose content was normally distributed in the accessions around a mean and median of 45% (w/w. Genome-wide marker-trait association study using 21,073 SNPs helped identify nine SNPs that were associated (p < 1E-05 with cellulose content. Four strongly associated (p < 8.17E-05 SNP markers were linked to wheat unigenes, which included β-tubulin, Auxin-induced protein 5NG4, and a putative transmembrane protein of unknown function. These genes may be directly or indirectly involved in the formation of cellulose in wheat culms. GWAS results from this study have the potential for genetic manipulation of cellulose content in bread wheat and other small grain cereals to enhance culm strength and improve biofuel production.

Common and Rare Variant Association Study for Plasma Lipids and Coronary Artery Disease.

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Tada, Hayato; Kawashiri, Masa-aki; Konno, Tetsuo; Yamagishi, Masakazu; Hayashi, Kenshi

2016-01-01

Blood lipid levels are highly heritable and modifiable risk factors for coronary artery disease (CAD), and are the leading cause of death worldwide. These facts have motivated human genetic association studies that have the substantial potential to define the risk factors that are causal and to identify pathways and therapeutic targets for lipids and CAD.The success of the HapMap project that provided an extensive catalog of human genetic variations and the development of microarray based genotyping chips (typically containing variations with allele frequencies ＞ 5%) facilitated common variant association study (CVAS; formerly termed genome-wide association study, GWAS) identifying disease-associated variants in a genome-wide manner. To date, 157 loci associated with blood lipids and 46 loci with CAD have been successfully identified, accounting for approximately 12%-14% of heritability for lipids and 10% of heritability for CAD. However, there is yet a major challenge termed "missing heritability problem," namely the observation that loci detected by CVAS explain only a small fraction of the inferred genetic variations. To explain such missing portions, focuses in genetic association studies have shifted from common to rare variants. However, it is challenging to apply rare variant association study (RVAS) in an unbiased manner because such variants typically lack the sufficient number to be identified statistically.In this review, we provide a current understanding of the genetic architecture mostly derived from CVAS, and several updates on the progress and limitations of RVAS for lipids and CAD.

Subthalamic nucleus stimulation affects limbic and associative circuits: a PET study

International Nuclear Information System (INIS)

Le Jeune, Florence; Peron, Julie; Grandjean, Didier; Drapier, Sophie; Verin, Marc; Haegelen, Claire; Garin, Etienne; Millet, Bruno

2010-01-01

Although high-frequency deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in advanced Parkinson's disease (PD), clinical studies have reported cognitive, motivational and emotional changes. These results suggest that the STN forms part of a broadly distributed neural network encompassing the associative and limbic circuits. We sought to pinpoint the cortical and subcortical brain areas modulated by STN DBS, in order to assess the STN's functional role and explain neuropsychological modifications following STN DBS in PD. We studied resting state glucose metabolism in 20 PD patients before and after STN DBS and 13 age-matched healthy controls using 18 F-FDG PET. We used statistical analysis (SPM2) first to compare pre-stimulation metabolism in PD patients with metabolism in healthy controls, then to study metabolic modifications in PD patients following STN DBS. The first analysis revealed no pre-stimulation metabolic abnormalities in associative or limbic circuitry. After STN DBS, metabolic modifications were found in several regions known for their involvement in the limbic and associative circuits. These metabolic results confirm the STN's central role in associative and limbic basal ganglia circuits. They will provide information for working hypotheses for future studies investigating neuropsychological changes and metabolic modifications related to STN DBS, with a view to improving our knowledge of this structure's functional role. (orig.)

Subthalamic nucleus stimulation affects limbic and associative circuits: a PET study

Energy Technology Data Exchange (ETDEWEB)

Le Jeune, Florence [Centre Eugene Marquis, Service de Medecine Nucleaire, Rennes (France); Universite Rennes 1, Hopital Pontchaillou, CHU de Rennes, Unite de Recherche Universitaire ' ' Comportement et Noyaux Gris Centraux' ' , Rennes (France); Centre Eugene Marquis, Service Medecine Nucleaire, Rennes (France); Peron, Julie [Universite Rennes 1, Hopital Pontchaillou, CHU de Rennes, Unite de Recherche Universitaire ' ' Comportement et Noyaux Gris Centraux' ' , Rennes (France); Hopital Pontchaillou, CHU de Rennes, Clinique Neurologique, Rennes (France); University of Geneva, Neuroscience of Emotion and Affective Dynamics, Department of Psychology and Swiss Center for Affective Sciences, Geneva (Switzerland); Grandjean, Didier [University of Geneva, Neuroscience of Emotion and Affective Dynamics, Department of Psychology and Swiss Center for Affective Sciences, Geneva (Switzerland); Drapier, Sophie; Verin, Marc [Universite Rennes 1, Hopital Pontchaillou, CHU de Rennes, Unite de Recherche Universitaire ' ' Comportement et Noyaux Gris Centraux' ' , Rennes (France); Hopital Pontchaillou, CHU de Rennes, Clinique Neurologique, Rennes (France); Haegelen, Claire [Universite Rennes 1, Hopital Pontchaillou, CHU de Rennes, Unite de Recherche Universitaire ' ' Comportement et Noyaux Gris Centraux' ' , Rennes (France); Hopital Pontchaillou, CHU de Rennes, Service de Neurochirurgie, Rennes (France); Garin, Etienne [Centre Eugene Marquis, Service de Medecine Nucleaire, Rennes (France); Millet, Bruno [Universite Rennes 1, Hopital Pontchaillou, CHU de Rennes, Unite de Recherche Universitaire ' ' Comportement et Noyaux Gris Centraux' ' , Rennes (France); S.H.U. Psychiatrie Adulte, CH Guillaume Regnier, Rennes (France)

2010-08-15

Although high-frequency deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in advanced Parkinson's disease (PD), clinical studies have reported cognitive, motivational and emotional changes. These results suggest that the STN forms part of a broadly distributed neural network encompassing the associative and limbic circuits. We sought to pinpoint the cortical and subcortical brain areas modulated by STN DBS, in order to assess the STN's functional role and explain neuropsychological modifications following STN DBS in PD. We studied resting state glucose metabolism in 20 PD patients before and after STN DBS and 13 age-matched healthy controls using {sup 18}F-FDG PET. We used statistical analysis (SPM2) first to compare pre-stimulation metabolism in PD patients with metabolism in healthy controls, then to study metabolic modifications in PD patients following STN DBS. The first analysis revealed no pre-stimulation metabolic abnormalities in associative or limbic circuitry. After STN DBS, metabolic modifications were found in several regions known for their involvement in the limbic and associative circuits. These metabolic results confirm the STN's central role in associative and limbic basal ganglia circuits. They will provide information for working hypotheses for future studies investigating neuropsychological changes and metabolic modifications related to STN DBS, with a view to improving our knowledge of this structure's functional role. (orig.)

Factors associated with voice disorders among teachers: a case-control study.

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Giannini, Susana Pimentel Pinto; Latorre, Maria do Rosário Dias de Oliveira; Ferreira, Léslie Piccolotto

2013-01-01

We aimed at verifying an association between voice disorders/stress and loss of work ability among female teachers who work in São Paulo's public school system. This is a paired case- control study. The case group was composed offiteachers with alterations in speech and larynges assessments, and the control group was formed by teachers without alterations in these evaluations who work in the same schools. Both groups answered the following questionnaires: Conditions of Vocal Production-Teachers, Job Stress Scale, and Work Ability Index. The analysis was performed using the chi-square association test and logistic regression models with the purpose of estimating the association between independent variables and voice disorders. We found differences between the groups in relation to stress in the workplace under high demand, a situation that poses greater risks of adverse reactions to the workers' physical and mental health. Regarding the ability to work, the categories poor and moderate ability for work are associated with voice disorders, regardless of job stress factors, age, and the unsatisfactory acoustic properties of the classrooms. This study confirmed the association between voice disorders and job stress, as well as between voice disorders and loss of work ability.

Anticholinergic, antihistaminic, and antiserotonergic activity of n-hexane extract of Zanthoxylum alatum seeds on isolated tissue preparations: An ex vivo study.

Science.gov (United States)

Saikia, Beenita; Barua, Chandana Choudhury; Haloi, Prakash; Patowary, Pompy

2017-01-01

The aim of this study was to evaluate anticholinergic, antihistaminic, and antiserotonergic activity of the n-hexane extract of the seeds of Zanthoxylum alatum (ZAHE) on isolated ileum of rat and guinea pig and fundus of rat. ZAHE was prepared using soxhlet extraction and cumulative concentration response curves were constructed using various doses on the tissues for acetylcholine (ACh), 5-hydroxytryptamine (5-HT), and histamine with or without n-hexane extract. Atropine, ketanserin, and pheniramine maleate were used as antagonists for ACh, serotonin, and histamine, respectively. ZAHE-induced concentration-dependent inhibition of isolated ileum and fundus in rat and ileum of guinea pig. The half maximal effective concentration (EC 50 ) of ACh in the presence of atropine (10 -6 M; P pheniramine maleate (10 -6 M; P < 0.01) and ZAHE (300 μg/ml; P < 0.01 and 1000 μg/ml; P < 0.05) was also significantly higher than EC 50 of histamine alone. From the study, it was observed that ZAHE shows significant anticholinergic, antiserotonergic, and antihistaminic activity. The study provides sufficient evidence that the seeds can be used in gastric disorders, cough, chest infection, etc., as per folklore claims.

Factors associated with adolescent cigarette smoking in Greece: results from a cross sectional study (GYTS Study).

Science.gov (United States)

Rachiotis, George; Muula, Adamson S; Rudatsikira, Emmanuel; Siziya, Seter; Kyrlesi, Athina; Gourgoulianis, Konstantinos; Hadjichristodoulou, Christos

2008-09-15

Data about the predictors of smoking among adolescents in Greece are sparse. We tried to identify factors associated with current cigarette smoking among in-school adolescents in Greece in the context of GYTS study. A secondary analysis of data from a questionnaire study using the Global Youth Tobacco Survey methodology was conducted to identify factors associated with smoking among adolescents in Greece. Data were collected in 2004-2005. The outcome variable was cigarette smoking within the past 30 days preceding the survey while independent variables included age, gender, parental educational status, parental smoking, perception of harmfulness of smoking, and the amount of pocket money at the adolescent's disposal. 6141 adolescents (51.5% males and 48.5% females) participated in the study. In multivariate analysis, cigarette smoking was associated with male gender (OR: 1.62; 95% CI: 1, 08-3.08), parental smoking (OR: 2.59; 95% CI: 1.45-5.89), and having pocket money > or = 16 Euros (OR: 2.64; 95% CI: 1.19-5.98). Male gender, parental smoking, and having pocket-money > or = 16 Euros were independently associated with current smoking among Greek students. These findings could be taken into account in order to formulate a comprehensive anti-smoking strategy in Greece.

Data analysis in the post-genome-wide association study era

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Qiao-Ling Wang

2016-12-01

Full Text Available Since the first report of a genome-wide association study (GWAS on human age-related macular degeneration, GWAS has successfully been used to discover genetic variants for a variety of complex human diseases and/or traits, and thousands of associated loci have been identified. However, the underlying mechanisms for these loci remain largely unknown. To make these GWAS findings more useful, it is necessary to perform in-depth data mining. The data analysis in the post-GWAS era will include the following aspects: fine-mapping of susceptibility regions to identify susceptibility genes for elucidating the biological mechanism of action; joint analysis of susceptibility genes in different diseases; integration of GWAS, transcriptome, and epigenetic data to analyze expression and methylation quantitative trait loci at the whole-genome level, and find single-nucleotide polymorphisms that influence gene expression and DNA methylation; genome-wide association analysis of disease-related DNA copy number variations. Applying these strategies and methods will serve to strengthen GWAS data to enhance the utility and significance of GWAS in improving understanding of the genetics of complex diseases or traits and translate these findings for clinical applications. Keywords: Genome-wide association study, Data mining, Integrative data analysis, Polymorphism, Copy number variation

Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.

Science.gov (United States)

Gueorguiev, Maria; Lecoeur, Cécile; Meyre, David; Benzinou, Michael; Mein, Charles A; Hinney, Anke; Vatin, Vincent; Weill, Jacques; Heude, Barbara; Hebebrand, Johannes; Grossman, Ashley B; Korbonits, Márta; Froguel, Philippe

2009-04-01

Ghrelin exerts a stimulatory effect on appetite and regulates energy homeostasis. Ghrelin gene variants have been shown to be associated with metabolic traits, although there is evidence suggesting linkage and association with obesity and the ghrelin receptor (GHSR). We hypothesized that these genes are good candidates for susceptibility to obesity. Direct sequencing identified 12 ghrelin single-nucleotide polymorphisms (SNPs) and 8 GHSR SNPs. The 10 common SNPs were genotyped in 1,275 obese subjects and in 1,059 subjects from a general population cohort of European origin. In the obesity case-control study, the GHSR SNP rs572169 was found to be associated with obesity (P = 0.007 in additive model, P = 0.001 in dominant model, odds ratio (OR) 1.73, 95% confidence interval (1.23-2.44)). The ghrelin variant, g.A265T (rs4684677), showed an association with obesity (P = 0.009, BMI adjusted for age and sex) in obese families. The ghrelin variant, g.A-604G (rs27647), showed an association with insulin levels at 2-h post-oral glucose tolerance test (OGTT) (P = 0.009) in obese families. We found an association between the eating behavior "overeating" and the GHSR SNP rs2232169 (P = 0.02) in obese subjects. However, none of these associations remained significant when corrected for multiple comparisons. Replication of the nominal associations with obesity could not be confirmed in a German genome-wide association (GWA) study for rs4684677 and rs572169 polymorphisms. Our data suggest that common polymorphisms in ghrelin and its receptor genes are not major contributors to the development of polygenic obesity, although common variants may alter body weight and eating behavior and contribute to insulin resistance, in particular in the context of early-onset obesity.

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.

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Dehghan, Abbas; Köttgen, Anna; Yang, Qiong; Hwang, Shih-Jen; Kao, Wh Linda; Rivadeneira, Fernando; Boerwinkle, Eric; Levy, Daniel; Hofman, Albert; Astor, Brad C; Benjamin, Emelia J; van Duijn, Cornelia M; Witteman, Jacqueline C; Coresh, Josef; Fox, Caroline S

2008-12-06

Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout. Genome-wide association studies were done for serum uric acid in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nucleotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the study of Atherosclerosis Risk in Communities (ARIC). The SNPs that reached genome-wide significant association with uric acid in either the Framingham cohort (pgout. The results obtained in white participants were combined using meta-analysis. Three loci in the Framingham cohort and two in the Rotterdam cohort showed genome-wide association with uric acid. Top SNPs in each locus were: missense rs16890979 in SLC2A9 (p=7.0 x 10(-168) and 2.9 x 10(-18) for white and black participants, respectively); missense rs2231142 in ABCG2 (p=2.5 x 10(-60) and 9.8 x 10(-4)), and rs1165205 in SLC17A3 (p=3.3 x 10(-26) and 0.33). All SNPs were direction-consistent with gout in white participants: rs16890979 (OR 0.59 per T allele, 95% CI 0.52-0.68, p=7.0 x 10(-14)), rs2231142 (1.74, 1.51-1.99, p=3.3 x 10(-15)), and rs1165205 (0.85, 0.77-0.94, p=0.002). In black participants of the ARIC study, rs2231142 was direction-consistent with gout (1.71, 1.06-2.77, p=0.028). An additive genetic risk score of high-risk alleles at the three loci showed graded associations with uric acid (272-351 mumol/L in the Framingham cohort, 269-386 mumol/L in the Rotterdam cohort, and 303-426 mumol/L in white participants of the ARIC study) and gout (frequency 2-13% in the Framingham cohort, 2-8% in the Rotterdam cohort, and 1-18% in white participants in the ARIC study). We identified three genetic loci associated with uric acid concentration and gout. A score based on genes with a putative role in renal urate handling showed a substantial risk

Stéfan Einarsson, STUDIES IN GERMANIC PHILOLOGY, edited by Anatoly Li­bermann, Helmut Buske Verlag Hamburg 1986.

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Dora Maček

1987-12-01

Full Text Available This is a miscellany of 12 articles selected from such periodicals as The Journal of English and Germanic Philology, Language, Arkiv för nordisk filologi, PMLA, Budkavlen etc, issued between 1932 and 1964. The editor A. Libermann has taken pains to cover Stéfan Einarsson's main scholarly interests, i.e. phonetics, semantics, metrics, folklore and historiography.  Moreover, he has provided the reader with some very important  discussions and views on Nordic, and particularly Icelandic linguistic and literary topics, which are nevertheless interesting for Germanic and other philologists in general. Though Icelandic and Scandinavian are at the centre of interest, examples and parallels are drawn from other languages and cultures parti­ cularly English and Finnish.

Genome-wide association study of smoking behaviors in COPD patients

Science.gov (United States)

Siedlinski, Mateusz; Cho, Michael H.; Bakke, Per; Gulsvik, Amund; Lomas, David A.; Anderson, Wayne; Kong, Xiangyang; Rennard, Stephen I.; Beaty, Terri H.; Hokanson, John E.; Crapo, James D.; Silverman, Edwin K.

2012-01-01

Background Cigarette smoking is a major risk factor for COPD and COPD severity. Previous genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a Dopamine Beta-Hydroxylase (DBH) locus associated with smoking cessation in multiple populations. Objective To identify SNPs associated with lifetime average and current CPD, age at smoking initiation, and smoking cessation in COPD subjects. Methods GWAS were conducted in 4 independent cohorts encompassing 3,441 ever-smoking COPD subjects (GOLD stage II or higher). Untyped SNPs were imputed using HapMap (phase II) panel. Results from all cohorts were meta-analyzed. Results Several SNPs near the HLA region on chromosome 6p21 and in an intergenic region on chromosome 2q21 showed associations with age at smoking initiation, both with the lowest p=2×10−7. No SNPs were associated with lifetime average CPD, current CPD or smoking cessation with p<10−6. Nominally significant associations with candidate SNPs within alpha-nicotinic acetylcholine receptors 3/5 (CHRNA3/CHRNA5; e.g. p=0.00011 for SNP rs1051730) and Cytochrome P450 2A6 (CYP2A6; e.g. p=2.78×10−5 for a nonsynonymous SNP rs1801272) regions were observed for lifetime average CPD, however only CYP2A6 showed evidence of significant association with current CPD. A candidate SNP (rs3025343) in the DBH was significantly (p=0.015) associated with smoking cessation. Conclusion We identified two candidate regions associated with age at smoking initiation in COPD subjects. Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviors of COPD patients. PMID:21685187

Association of diabetes mellitus and dementia : The Rotterdam study

NARCIS (Netherlands)

Ott, A; Stolk, RP; Hofman, A; vanHarskamp, F; Grobbee, DE; Breteler, MMB

1996-01-01

Dementia and non-insulin-dependent diabetes mellitus (NIDDM) are highly prevalent disorders in the elderly. Diabetes has repeatedly been reported to affect cognition, but its relation with dementia is uncertain. We therefore studied the association between diabetes and dementia in the Rotterdam

Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies

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Qiong Yang

2012-01-01

Full Text Available Multivariate phenotypes are frequently encountered in genetic association studies. The purpose of analyzing multivariate phenotypes usually includes discovery of novel genetic variants of pleiotropy effects, that is, affecting multiple phenotypes, and the ultimate goal of uncovering the underlying genetic mechanism. In recent years, there have been new method development and application of existing statistical methods to such phenotypes. In this paper, we provide a review of the available methods for analyzing association between a single marker and a multivariate phenotype consisting of the same type of components (e.g., all continuous or all categorical or different types of components (e.g., some are continuous and others are categorical. We also reviewed causal inference methods designed to test whether the detected association with the multivariate phenotype is truly pleiotropy or the genetic marker exerts its effects on some phenotypes through affecting the others.

FERMENTED MILK AS A FUNCTIONAL FOOD

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Irena Rogelj

2000-06-01

Full Text Available Certain foods have been associated with health benefits for many years; fermented milks and yoghurt are typical examples. The health properties of these dairy products were a part of folklore until the concept of probiotics emerged, and the study of fermented milks and yoghurt containing probiotic bacteria has become more systematic. Functional foods have thus developed as a food, or food ingredient, with positive effects on host health and/or well-being beyond their nutritional value, and fermented milk with probiotic bacteria has again become the prominent representative of this new category of food. Milk alone is much more than the sum of its nutrients. It contains an array of bioactivities: modulating digestive and gastrointestinal functions, haemodynamics, controlling probiotic microbial growth, and immunoregulation. When fermented milk is enriched with probiotic bacteria and prebiotics it meets all the requirements of functional food. The possible positive effects of enriched fermented milk on host health will be reviewed.

Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies.

Science.gov (United States)

Zhu, Ce; Li, Fei; Wong, May Chun Mei; Feng, Xi-Ping; Lu, Hai-Xia; Xu, Wei

2015-01-01

Numerous studies have investigated the associations between herpesviruses and chronic periodontitis; however, the results remain controversial. To derive a more precise estimation, a meta-analysis on all available studies was performed to identify the association between herpesviruses and chronic periodontitis. A computerized literature search was conducted in December 2014 to identify eligible case-control studies from the PUBMED and EMBASE databases according to inclusion and exclusion criteria. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were used to assess the association between herpesviruses and risk of chronic periodontitis. A fixed or random effects model was determined based on a heterogeneity test. Sensitivity analysis was conducted to investigate stability and reliability. Publication bias was investigated using the Begg rank correlation test and Egger's funnel plot. Ten eligible studies were included to investigate the association between Epstein-Barr virus (EBV) and chronic periodontitis. The results showed that EBV has a significant association with chronic periodontitis compared with periodontally healthy group (OR = 5.74, 95% CI = 2.53-13.00, Pchronic periodontitis was analyzed in 10 studies. The pooled result showed that HCMV also has a significant association with chronic periodontitis (OR = 3.59, 95% CI = 1.41-9.16, P = 0.007). Similar results were found in the sensitivity analyses. No significant publication bias was observed. Two eligible studies were included to investigate the association between herpes simplex virus (HSV) and chronic periodontitis risk. The association between HSV and chronic periodontitis was inconclusive (OR = 2.81 95% CI = 0.95-8.27, P = 0.06). Only one included study investigated the association between human herpesvirus 7 (HHV-7) and chronic periodontitis risk (OR = 1.00, 95% CI = 0.21-4.86). The findings of this meta-analysis suggest that two members of the herpesvirus family, EBV

'Smoking genes': a genetic association study.

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Zoraida Verde

Full Text Available Some controversy exists on the specific genetic variants that are associated with nicotine dependence and smoking-related phenotypes. The purpose of this study was to analyse the association of smoking status and smoking-related phenotypes (included nicotine dependence with 17 candidate genetic variants: CYP2A6*1×2, CYP2A6*2 (1799T>A [rs1801272], CYP2A6*9 (-48T>G [rs28399433], CYP2A6*12, CYP2A13*2 (3375C>T [rs8192789], CYP2A13*3 (7520C>G, CYP2A13*4 (579G>A, CYP2A13*7 (578C>T [rs72552266], CYP2B6*4 (785A>G, CYP2B6*9 (516G>T, CHRNA3 546C>T [rs578776], CHRNA5 1192G>A [rs16969968], CNR1 3764C>G [rs6928499], DRD2-ANKK1 2137G>A (Taq1A [rs1800497], 5HTT LPR, HTR2A -1438A>G [rs6311] and OPRM1 118A>G [rs1799971]. We studied the genotypes of the aforementioned polymorphisms in a cohort of Spanish smokers (cases, N = 126 and ethnically matched never smokers (controls, N = 80. The results showed significant between-group differences for CYP2A6*2 and CYP2A6*12 (both PA (Taq1A polymorphisms was 3.60 (95%CI: 1.75, 7.44 and 2.63 (95%CI: 1.41, 4.89 respectively. Compared with the wild-type genotype, the OR for being a non-smoker in carriers of the minor CYP2A6*2 allele was 1.80 (95%CI: 1.24, 2.65. We found a significant genotype effect (all P≤0.017 for the following smoking-related phenotypes: (i cigarettes smoked per day and CYP2A13*3; (ii pack years smoked and CYP2A6*2, CYP2A6*1×2, CYP2A13*7, CYP2B6*4 and DRD2-ANKK1 2137G>A (Taq1A; (iii nicotine dependence (assessed with the Fagestrom test and CYP2A6*9. Overall, our results suggest that genetic variants potentially involved in nicotine metabolization (mainly, CYP2A6 polymorphisms are those showing the strongest association with smoking-related phenotypes, as opposed to genetic variants influencing the brain effects of nicotine, e.g., through nicotinic acetylcholine (CHRNA5, serotoninergic (HTR2A, opioid (OPRM1 or cannabinoid receptors (CNR1.

Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies.

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Roman Pfister

2011-10-01

Full Text Available Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP levels in blood and risk of type 2 diabetes (T2D, but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded.We analysed the association between levels of the N-terminal fragment of pro-BNP (NT-pro-BNP in blood and risk of incident T2D in a prospective case-cohort study and genotyped the variant rs198389 within the BNP locus in three T2D case-control studies. We combined our results with existing data in a meta-analysis of 11 case-control studies. Using a Mendelian randomization approach, we compared the observed association between rs198389 and T2D to that expected from the NT-pro-BNP level to T2D association and the NT-pro-BNP difference per C allele of rs198389. In participants of our case-cohort study who were free of T2D and cardiovascular disease at baseline, we observed a 21% (95% CI 3%-36% decreased risk of incident T2D per one standard deviation (SD higher log-transformed NT-pro-BNP levels in analysis adjusted for age, sex, body mass index, systolic blood pressure, smoking, family history of T2D, history of hypertension, and levels of triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. The association between rs198389 and T2D observed in case-control studies (odds ratio = 0.94 per C allele, 95% CI 0.91-0.97 was similar to that expected (0.96, 0.93-0.98 based on the pooled estimate for the log-NT-pro-BNP level to T2D association derived from a meta-analysis of our study and published data (hazard ratio = 0.82 per SD, 0.74-0.90 and the difference in NT-pro-BNP levels (0.22 SD, 0.15-0.29 per C allele of rs198389. No significant associations were observed between the rs198389 genotype and potential confounders.Our results provide evidence for a potential causal role of the BNP system in the aetiology of T2D. Further studies

Ethnomedicinal review of folklore medicinal plants belonging to family Apiaceae of Pakistan

International Nuclear Information System (INIS)

Ikram, A.; Zahra, N.B.

2015-01-01

The use of herbs for therapeutic purpose is as old as human history. In Pakistan a major part of population is dependent on the traditional medicine derived from plants for primary health care system. The interest in the use of traditional system of medicine has gained popularity globally. The developed countries are shifting their focus to further research based on the indigenous knowledge collected from aboriginal people. The present study reviews the ethno-medicinal uses of family Apiaceae reported from Pakistan. Out of 167 species reported from Pakistan, 66 are found to be used medicinally. Most commonly treated disorders by use of Apiaceae herbal flora are gastrointestinal tract and liver disorders (28%) followed by cough, cold and respiratory tract problems (11%). The plant parts frequently used are roots (22%) followed by whole plant material (19%), leaf material (18%), fruit (13%), seed (12%), stem, flower, aerial parts (5%) and sap (1%). It is suggested to carry out similar studies for other families to explore the indigenous knowledge for the development of commercial products and to collectively document the scattered existing knowledge. (author)

A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study

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Han Thang S

2011-01-01

Full Text Available Abstract Background A number of single nucleotide polymorphisms (SNPs have been associated with broadband ultrasound attenuation (BUA and speed of sound (SOS as measured by quantitative ultrasound (QUS at the calcaneus in the Framingham 100K genome-wide association study (GWAS but have not been validated in independent studies. The aim of this analysis was to determine if these SNPs are associated with QUS measurements assessed in a large independent population of European middle-aged and elderly men. The association between these SNPs and bone mineral density (BMD measured using dual-energy X-ray absorptiometry (DXA was also tested. Methods Men aged 40-79 years (N = 2960 were recruited from population registers in seven European centres for participation in an observational study of male ageing, the European Male Ageing Study (EMAS. QUS at the calcaneus was measured in all subjects and blood was taken for genetic analysis. Lumbar spine (LS, femoral neck (FN and total hip (TH BMD were measured by DXA in a subsample of 620 men in two centres. SNPs associated with BUA or SOS in the Framingham study with p -4 were selected and genotyped using SEQUENOM technology. Linear regression was used to test for the association between SNPs and standardised (SD bone outcomes under an additive genetic model adjusting for centre. The same direction of effect and p Results Thirty-four of 38 selected SNPs were successfully genotyped in 2377 men. Suggestive evidence of replication was observed for a single SNP, rs3754032, which was associated with a higher SOS (β(SD = 0.07, p = 0.032 but not BUA (β(SD = 0.02, p = 0.505 and is located in the 3'UTR of WDR77 (WD repeat domain 77 also known as androgen receptor cofactor p44. A single SNP, rs238358, was associated with BMD at the LS (β(SD = -0.22, p = 0.014, FN (β(SD = -0.31,p = 0.001 and TH (β(SD = -0.36, p = 0.002 in a locus previously associated with LS BMD in large-scale GWAS, incorporating AKAP11 and RANKL

Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS

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Mattheisen, Manuel; Samuels, Jack F.; Wang, Ying; Greenberg, Benjamin D.; Fyer, Abby J.; McCracken, James T.; Geller, Daniel A.; Murphy, Dennis L.; Knowles, James A.; Grados, Marco A.; Riddle, Mark A.; Rasmussen, Steven A.; McLaughlin, Nicole C.; Nurmi, Erica; Askland, Kathleen D.; Qin, Hai-De; Cullen, Bernadette A.; Piacentini, John; Pauls, David L.; Bienvenu, O. Joseph; Stewart, S. Evelyn; Liang, Kung-Yee; Goes, Fernando S.; Maher, Brion; Pulver, Ann E.; Shugart, Yin-Yao; Valle, David; Lange, Cristoph; Nestadt, Gerald

2014-01-01

Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning. The OCD Collaborative Genetics Association Study (OCGAS) is comprised of comprehensively assessed OCD patients, with an early age of OCD onset. After application of a stringent quality control protocol, a total of 1 065 families (containing 1 406 patients with OCD), combined with population-based samples (resulting in a total sample of 5 061 individuals), were studied. An integrative analyses pipeline was utilized, involving association testing at SNP- and gene-levels (via a hybrid approach that allowed for combined analyses of the family- and population-based data). The smallest P-value was observed for a marker on chromosome 9 (near PTPRD, P=4.13×10−7). Pre-synaptic PTPRD promotes the differentiation of glutamatergic synapses and interacts with SLITRK3. Together, both proteins selectively regulate the development of inhibitory GABAergic synapses. Although no SNPs were identified as associated with OCD at genome-wide significance level, follow-up analyses of GWAS signals from a previously published OCD study identified significant enrichment (P=0.0176). Secondary analyses of high confidence interaction partners of DLGAP1 and GRIK2 (both showing evidence for association in our follow-up and the original GWAS study) revealed a trend of association (P=0.075) for a set of genes such as NEUROD6, SV2A, GRIA4, SLC1A2, and PTPRD. Analyses at the gene-level revealed association of IQCK and C16orf88 (both P<1×10−6, experiment-wide significant), as well as OFCC1 (P=6.29×10−5). The suggestive findings in this study await replication in larger samples. PMID:24821223

Association between obesity and chronic periodontitis: a cross-sectional study.

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Palle, Ajay Reddy; Reddy, C M Sanjeeva Kumar; Shankar, B Shiva; Gelli, Vemsi; Sudhakar, Jaradoddi; Reddy, K Krishna Mohana

2013-03-01

Chronic periodontitis is multifactorial and numerous risk factors have been identified to contribute in the disease progression. Current study aimed to conduct a cross-sectional study in a population of patients with cardiovascular diseases in order to correlate the association between obesity [body mass index (BMI) and waist circumference (WC)] and periodontal disease parameters. The study was of a cross-sectional design and a total of 201 patients were examined after obtaining their informed consent. Subjects who had a history of cardiovascular diseases and under treatment were included in the study. Two indicators of obesity were used: BMI and WC. The following periodontal parameters were assessed: Probing depth, clinical attachment level. The oral hygiene status of the subjects was assessed by the oral hygiene index (OHI, simplified) given by John C Greene and Jack R Vermillion. The influence of the BMI and other confounding variables on periodontitis severity was assessed by multivariate logistic regression analysis. Data were analyzed using SPSS. Significant association was seen with low density lipoproteins (LDL) and severity of periodontitis (p < 0.005), triglyceride levels (TGL) and severity of periodontitis (p < 0.005), cholesterol and severity of periodontitis (p < 0.005), BMI and severity of periodontitis (p < 0.001), OHI and severity of periodontitis (p < 0.001). Significant association was seen with smoking and severity of periodontitis (p < 0.005), BMI and severity of periodontitis (p < 0.001), WC and severity of periodontitis (p < 0.001), cholesterol and severity of periodontitis (p < 0.001), OHI and severity of periodontitis (p < 0.001). Obesity has been implicated as a risk factor for several conditions including cardiovascular disease, diabetes, etc. In our study the relation between measures of overall and abdominal obesity (BMI and WC) and periodontal disease showed significant association in the multivariate logistic regression analysis

[Mother-newborn relational risk - Study of prevalence and associated variables].

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Muñoz, Maribel; Poo, Ana María; Baeza, Bernardita; Bustos, M Luis

2015-01-01

Clinical evidence reveals the importance of mother-newborn bonding experience for health promoting and maintenance of human life. If the newborn lacks care and affection, she/he may develop an attachment disorder. A predictive scale regarding the risk of mothernewborn relationships is available, which makes possible an early intervention to prevent the development of relational disorders. The aim of this study is to apply the Kimelman measurement scale to determine the relational risk in mother-newborn pairs, as well as the prevalence and the associated biopsychosocial variables. A cross-sectional study with a probabilistic sample of 333 mother-infant pairs in postpartum maternity at Temuco hospital. The Kimelman mother-newborn attachment assessment guide was used. Biopsychosocial variables were obtained from the mothers studied. The association of biopsychosocial variables with relational risk was analyzed using OR and confidence intervals of 95%. The prevalence of high relational risk was 43.8%. The associated biopsychosocial variables included, women with no steady partner, single parent, teenage mothers, unwanted and unplanned pregnancy. Almost half of the mothers were in the high risk group. Early identification of relational risk and its related variables could help in the intervention in this vulnerable group. Copyright © 2015. Publicado por Elsevier España, S.L.U.

Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies.

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Saliba, Walid; Rennert, Hedy S; Gronich, Naomi; Gruber, Stephen B; Rennert, Gad

2018-01-01

An association between atrial fibrillation (AF) and risk of cancer has been suggested in several studies, including prospective cohort studies. However, the magnitude and the temporal nature of this association remain unclear. Data from two large prospective population-based case-control studies, the Molecular Epidemiology of Colorectal Cancer (MECC, n = 8,383) and the Breast Cancer in Northern Israel Study (BCINIS, n = 11,608), were used to better understand the nature and temporality of a possible association between cancer diagnosis and AF events before and after cancer diagnosis. A case-control study approach was employed to study prior AF as a risk factor for cancer, and a cohort study approach was employed to study incident cancer as a risk factor for AF. AF was associated with a significant reduced odds of cancer as reflected in the case-control approach, with an adjusted OR = 0.77 (95% CI, 0.65-0.91), while cancer was not found to be significantly associated with elevated risk of AF in the cohort approach, with an adjusted HR = 1.10 (0.98-1.23). The immediate period (90 days) after an AF event was associated with a 1.85 times increased risk of cancer, and the immediate period after the diagnosis of cancer was associated with a 3.4 fold increased risk of AF. These findings probably reflect both the effect of acute transient conditions associated with new cancer diagnosis and detection bias. Similar results were identified with colorectal and breast cancer cases. Atrial fibrillation of longer than 90 days duration is associated with reduced odds of new cancer diagnosis. The results of this study suggest that an association observed in prior research may be due to instances related to cancer diagnosis and detection bias rather than a causal relationship. However, there may be bias in the sampling and residual confounding that distort the associations.

Antidiabetic and haematinic effects of Parquetina nigrescens on ...

African Journals Online (AJOL)

Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats. ... Background: The plant, Parquetina nigrescens is used in folklore medicine to treat diabetes mellitus and its complications in several parts of West Africa. Objective: To ...

Golden Hindesight, Homespun, Lagniappe, et al.

Science.gov (United States)

Reynolds, Sherrod

1979-01-01

Described are cultural journalism projects around the country which have used the "Foxfire Approach" successfully. "Foxfire" is a student-run magazine dedicated to the collection and preservation of the oral history, folklore and folklife (or traditional culture) of the students' own locality. Included is a list of…

Themes of Suicide in the Kalevala.

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Achte, Kalle; And Others

1988-01-01

The Kalevala, Finland's national epic, is a crucial element of Finnish cultural identity and important to Finnish culture. Violence, death, and suicide are often repeated themes in Finnish folklore. The Kalevala provides insight into past attitudes toward death. Traditions passed through generations have influenced people's attitudes toward…

Etnologie studené války v České republice: témata, přístupy, metody

Czech Academy of Sciences Publication Activity Database

Woitsch, Jiří

33 /75/, č. 2 (2016), s. 5-30 ISSN 1211-8117 R&D Projects: GA ČR GA15-03754S Institutional support: RVO:68378076 Keywords : Cold War * Iron Curtain * borders * theory and methodology * landscape * memory * folklore * heritage * history of ethnology Subject RIV: AC - Archeology, Anthropology, Ethnology

AFRREV IJAH, Vol.1 (1) Feb., 2012

African Journals Online (AJOL)

User

Myth is one of the elements of folklore and its importance in the matrix of. African culture can never ... How myth helped the author to sharpen and create her conflicts which led to the ... Ita is a type of story which is purported to have happened.

Healing, health, and horticulture: introduction to the workshop

Science.gov (United States)

The present-day emphasis of horticulture and health is an extension of ancient and medieval traditions. The relationship of healing and the horticultural arts predates written history and relates to ancient wisdom, custom, and folklore. Plants and health have been of great concern for humankind cons...

Some biological activities of Pycnanthus angolensis (Welw.) Warb ...

African Journals Online (AJOL)

These findings indicate a correlation in the activities of the leaves and as such serve as panacea for infectious diseases and therefore scientific justification to some of the folkloric uses of the plant. Keywords: Antimicrobial; Larvicidal; Brine shrimp lethality; Pycnanthus angolensis. Journal of Pharmacy and Bioresources Vol.

Kalevala tõht eesti eeposele / Jaan Puhvel

Index Scriptorium Estoniae

Puhvel, Jaan, 1932-

2007-01-01

F. R. Kreutzwaldi "Kalevipoeg" ja E. Lönnroti "Kalevala". Ilmunud: The Impact of the Kalevala on the Estonian Epic. - The World of the Kalevala: Essays in Celebration of the Publication of the Finnish National Epic. Los Angeles : UCLA Folklore and Mythology Publications, 1987, lk. 56-65

Antimicrobial activity of extracts of leaves of Pseudocedrela kotschyi ...

African Journals Online (AJOL)

The aim of the experiment was to investigate the phytochemical composition and antimicrobial activity of extracts of Pseudocedrela kotschyi (Schweinf.) Harms used in folklore medicine in order to authenticate some of its therapeutic claims. The antimicrobial activity of petroleum ether, ethyl acetate and methanol extracts of ...

Preserving American Folk Heritage through Story and Song.

Science.gov (United States)

Jalongo, Mary Renck

Underscoring folklore's appropriateness to multicultural classroom settings are its connection with past and present cultures, its constancy and change, and its potential for oral transmission of human values. Most importantly, folktales and songs enable children to participate in the history of universal human emotions. To effectively include…

Association Between Anemia and Cerebral Venous Thrombosis: Case-Control Study

NARCIS (Netherlands)

Coutinho, Jonathan M.; Zuurbier, Susanna M.; Gaartman, Aafke E.; Dikstaal, Arienne A.; Stam, Jan; Middeldorp, Saskia; Cannegieter, Suzanne C.

2015-01-01

Anemia is often considered to be a risk factor for cerebral venous thrombosis (CVT), but this assumption is mostly based on case reports. We investigated the association between anemia and CVT in a controlled study. Unmatched case-control study: cases were adult patients with CVT included in a

Characteristics Associated with Hallux Valgus in a Population-Based Study of Older Adults: The Framingham Foot Study

Science.gov (United States)

Dufour, Alyssa B.; Casey, Virginia A.; Golightly, Yvonne M.; Hannan, Marian T.

2015-01-01

Objective Hallux valgus (HV) is common in older adults, but limited studies of risk factors have reported conflicting results. This cross-sectional analysis examined the association of HV with foot pain and other characteristics in older adults. Methods HV, foot pain, foot structure (planus, rectus, cavus), current and past high heel use, age, and body mass index were assessed in the population-based Framingham Foot Study. Sex-specific logistic and multinomial logistic regression examined the association of HV and HV with pain with study variables. Results Of 1352 men and 1725 women (mean age 66 ± 10.5 years), 22% of men and 44% of women had HV and 3% of men and 11% of women had HV with pain. Foot pain increased odds of HV in both sexes (p 30 kg/m2 decreased odds of HV by 33% in men and 45% in women (p<0.05). In women only, odds of Pain & HV vs. No Pain & No HV were greater with older age and planus foot structure. Conclusions Our work showed different associations in participants who had HV with pain compared to those without foot pain. In both men and women, strong relations were observed between HV and foot pain and inversely with BMI. Older age was associated with HV in women only, as were protective associations with cavus foot structure. PMID:24965070

Associations of Coffee Drinking and Cancer Mortality in the Cancer Prevention Study-II.

Science.gov (United States)

Gapstur, Susan M; Anderson, Rebecca L; Campbell, Peter T; Jacobs, Eric J; Hartman, Terryl J; Hildebrand, Janet S; Wang, Ying; McCullough, Marjorie L

2017-10-01

Background: Associations of coffee consumption with cancer mortality are inconsistent for many types of cancer, and confounding by smoking is an important concern. Methods: Cox proportional hazards regression was used to estimate multivariable-adjusted HRs for coffee consumption associated with death from all cancers combined and from specific cancer types among 922,896 Cancer Prevention Study-II participants ages 28-94 years who completed a four-page questionnaire and were cancer free at baseline in 1982. Results: During follow-up through 2012, there were 118,738 cancer-related deaths. There was a nonlinear association between coffee consumption and all-cancer death among current smokers and former smokers and no association among never smokers. Among nonsmokers, a 2 cup/day increase in coffee consumption was inversely associated with death from colorectal [HR = 0.97; 95% confidence interval (CI) 0.95-0.99], liver [HR = 0.92; 95% CI, 0.88-0.96], and female breast (HR = 0.97; 95% CI, 0.94-0.99) cancers, and positively associated with esophageal cancer-related death (HR = 1.07; 95% CI, 1.02-1.12). For head and neck cancer, a nonlinear inverse association was observed starting at 2-3 cups per day (HR = 0.72; 95% CI, 0.55-0.95), with similar associations observed at higher levels of consumption. Conclusions: These findings are consistent with many other studies that suggest coffee drinking is associated with a lower risk of colorectal, liver, female breast, and head and neck cancer. The association of coffee consumption with higher risk of esophageal cancer among nonsmokers in our study should be confirmed. Impact: These results underscore the importance of assessing associations between coffee consumption and cancer mortality by smoking status. Cancer Epidemiol Biomarkers Prev; 26(10); 1477-86. ©2017 AACR . ©2017 American Association for Cancer Research.

PERAN DONGENG BAGI PERKEMBANGAN DAN PEMBENTUKAN KEPRIBADIAN ANAK

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Ipriansyah Ipriansyah

2011-06-01

Full Text Available Abstract:Various forms of folklore such as fairy tales are almost extinct because they are less popular compared to some TV shows. Even though various forms of folklore are only a fewbut it teaches positive values that are useful for children's development. Tale, for example, is believed to have an important role in helping cognitive development such as language, thought, and sosioemosional of a child such as emotions and personality. A fairy tale is quite reasonable to have an important role toward the development of children. Development is a pattern of change as a result of biological, cognitive, and sosioemosional processes which has begun  from the time of conception until the rest of a lifetime .Among periods of human development, there is a phase of human development which refers to the storytelling phase, that  is when a child is in the age of  5 to 8 years. Kata kunci: fairy tales/stories, child development, child's personality

African Oral Literature and the Humanities: Challenges and Prospects

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Enongene Mirabeau Sone

2018-03-01

Full Text Available This paper examines the origin, evolution and emergence of folklore (oral literature as an academic discipline in Africa and its place in the humanities. It draws attention to the richness of indigenous knowledge contained in oral literature and demonstrates how the ethical and moral gap in the existing educational system can be filled by the moral precepts embedded in oral literature. The paper argues that African oral literature has not received the attention it deserves among other disciplines of the humanities in institutions of higher learning in Africa. It concludes that any discussion on African literature will be incomplete, and indeed irrelevant, if it does not equally give adequate attention to the oral literature of the African people. As a result, a new curriculum and pedagogy must be designed to give pride of place to folklore and oral literature as the best repository of our cultural norms and values especially in African tertiary institutions.

Factors associated with adolescent cigarette smoking in Greece: Results from a cross sectional study (GYTS Study

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Gourgoulianis Konstantinos

2008-09-01

Full Text Available Abstract Background Data about the predictors of smoking among adolescents in Greece are sparse. We tried to identify factors associated with current cigarette smoking among in-school adolescents in Greece in the context of GYTS study. Methods A secondary analysis of data from a questionnaire study using the Global Youth Tobacco Survey methodology was conducted to identify factors associated with smoking among adolescents in Greece. Data were collected in 2004–2005. The outcome variable was cigarette smoking within the past 30 days preceding the survey while independent variables included age, gender, parental educational status, parental smoking, perception of harmfulness of smoking, and the amount of pocket money at the adolescent's disposal. Results 6141 adolescents (51.5% males and 48.5% females participated in the study. In multivariate analysis, cigarette smoking was associated with male gender (OR: 1.62; 95% CI: 1, 08–3.08, parental smoking (OR: 2.59; 95% CI: 1.45–5.89, and having pocket money ≥ 16 Euros (OR: 2.64; 95% CI: 1.19–5.98. Conclusion Male gender, parental smoking, and having pocket-money ≥ 16 Euros were independently associated with current smoking among Greek students. These findings could be taken into account in order to formulate a comprehensive anti-smoking strategy in Greece.

[Immigration and factors associated with breastfeeding. CALINA study].

Science.gov (United States)

Oves Suárez, B; Escartín Madurga, L; Samper Villagrasa, M P; Cuadrón Andrés, L; Alvarez Sauras, M L; Lasarte Velillas, J J; Moreno Aznar, L A; Rodríguez Martínez, G

2014-07-01

To identify socio-cultural, obstetric and perinatal characteristics associated with complete breastfeeding (CBF) during the first 4 months of age, depending on maternal origin. Socio-cultural, obstetric and perinatal aspects associated with breastfeeding depending on maternal origin were evaluated in a longitudinal study in a representative infant population from Aragon (n = 1452). The prevalence of CBF was higher in immigrant mothers than in those from Spain. CBF was maintained in 37.2% of mothers from Spain at 4 months, compared with 43% of immigrants (P=.039) (RR Spanish/immigrants=0.76; 95% CI: 0.58-0.99); at 6 months this occurred in 13.9% vs. 23.8%, respectively (P<.001) (RR Spanish/immigrants=0.52; 95% CI: 0.37-0.72). The factors associated with CBF at 4 months are different between both groups. Mothers born in Spain are older (P=.002), have higher academic level (P=.001), greater parity (P=.003), and a higher probability of vaginal delivery (P=.005); and their children have the highest anthropometric values at birth. However, in immigrant mothers, the maintenance of CBF was associated with a higher maternal body mass index and with working at home. In both groups, CBF remains more frequently in those mothers who do not smoke (P=.001). The prevalence of CBF during the first months of life is higher in immigrant mothers than in those from Spain, and socio-cultural, obstetric and perinatal factors are different, depending on maternal origin. Copyright © 2013 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

Evaluation of seven common lipid associated loci in a large Indian sib pair study.

Science.gov (United States)

Rafiq, Sajjad; Venkata, Kranthi Kumar M; Gupta, Vipin; Vinay, D G; Spurgeon, Charles J; Parameshwaran, Smitha; Madana, Sandeep N; Kinra, Sanjay; Bowen, Liza; Timpson, Nicholas J; Smith, George Davey; Dudbridge, Frank; Prabhakaran, Dorairaj; Ben-Shlomo, Yoav; Reddy, K Srinath; Ebrahim, Shah; Chandak, Giriraj R

2012-11-14

Genome wide association studies (GWAS), mostly in Europeans have identified several common variants as associated with key lipid traits. Replication of these genetic effects in South Asian populations is important since it would suggest wider relevance for these findings. Given the rising prevalence of metabolic disorders and heart disease in the Indian sub-continent, these studies could be of future clinical relevance. We studied seven common variants associated with a variety of lipid traits in previous GWASs. The study sample comprised of 3178 sib-pairs recruited as participants for the Indian Migration Study (IMS). Associations with various lipid parameters and quantitative traits were analyzed using the Fulker genetic association model. We replicated five of the 7 main effect associations with p-values ranging from 0.03 to 1.97x10(-7). We identified particularly strong association signals at rs662799 in APOA5 (beta=0.18 s.d, p=1.97 x 10(-7)), rs10503669 in LPL (beta =-0.18 s.d, p=1.0 x 10(-4)) and rs780094 in GCKR (beta=0.11 s.d, p=0.001) loci in relation to triglycerides. In addition, the GCKR variant was also associated with total cholesterol (beta=0.11 s.d, p=3.9x10(-4)). We also replicated the association of rs562338 in APOB (p=0.03) and rs4775041 in LIPC (p=0.007) with LDL-cholesterol and HDL-cholesterol respectively. We report associations of five loci with various lipid traits with the effect size consistent with the same reported in Europeans. These results indicate an overlap of genetic effects pertaining to lipid traits across the European and Indian populations.

Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians

Directory of Open Access Journals (Sweden)

Juliana Poletto

2011-02-01

Full Text Available This cross-sectional study aimed to estimate the prevalence of hyperuricemia and associated risk factors among Japanese-Brazilians. We obtained data on demographic, health history, food intake, and laboratory variables. Chi-square and prevalence ratios were used as measures of association. 35.3% of the subjects presented hyperuricemia, which was more frequent in smokers, males, age > 55 years, with co-morbidities, individuals on uric acid-increasing medication, serum creatinine > 1.4mg/dL, high alcohol consumption, and low consumption of milk and dairy products. In the multivariate analysis, the associations remained significant with gender, overweight, central obesity, hypertriglyceridemia, and use of specific drugs. Among males, low intake of saturated fat was associated with hyperuricemia. Individuals with hypertension showed a negative association with dairy product consumption. The high hyperuricemia prevalence suggests that changes in nutritional profile and control of associated co-morbidities could help minimize occurrence of this condition.

permGPU: Using graphics processing units in RNA microarray association studies

Directory of Open Access Journals (Sweden)

George Stephen L

2010-06-01

Full Text Available Abstract Background Many analyses of microarray association studies involve permutation, bootstrap resampling and cross-validation, that are ideally formulated as embarrassingly parallel computing problems. Given that these analyses are computationally intensive, scalable approaches that can take advantage of multi-core processor systems need to be developed. Results We have developed a CUDA based implementation, permGPU, that employs graphics processing units in microarray association studies. We illustrate the performance and applicability of permGPU within the context of permutation resampling for a number of test statistics. An extensive simulation study demonstrates a dramatic increase in performance when using permGPU on an NVIDIA GTX 280 card compared to an optimized C/C++ solution running on a conventional Linux server. Conclusions permGPU is available as an open-source stand-alone application and as an extension package for the R statistical environment. It provides a dramatic increase in performance for permutation resampling analysis in the context of microarray association studies. The current version offers six test statistics for carrying out permutation resampling analyses for binary, quantitative and censored time-to-event traits.

Sniffing out significant “Pee values”: genome wide association study of asparagus anosmia

Science.gov (United States)

Markt, Sarah C; Nuttall, Elizabeth; Turman, Constance; Sinnott, Jennifer; Rimm, Eric B; Ecsedy, Ethan; Unger, Robert H; Fall, Katja; Finn, Stephen; Jensen, Majken K; Rider, Jennifer R; Kraft, Peter

2016-01-01

Objective To determine the inherited factors associated with the ability to smell asparagus metabolites in urine. Design Genome wide association study. Setting Nurses’ Health Study and Health Professionals Follow-up Study cohorts. Participants 6909 men and women of European-American descent with available genetic data from genome wide association studies. Main outcome measure Participants were characterized as asparagus smellers if they strongly agreed with the prompt “after eating asparagus, you notice a strong characteristic odor in your urine,” and anosmic if otherwise. We calculated per-allele estimates of asparagus anosmia for about nine million single nucleotide polymorphisms using logistic regression. P values asparagus anosmia, all in a region on chromosome 1 (1q44: 248139851-248595299) containing multiple genes in the olfactory receptor 2 (OR2) family. Conditional analyses revealed three independent markers associated with asparagus anosmia: rs13373863, rs71538191, and rs6689553. Conclusion A large proportion of people have asparagus anosmia. Genetic variation near multiple olfactory receptor genes is associated with the ability of an individual to smell the metabolites of asparagus in urine. Future replication studies are necessary before considering targeted therapies to help anosmic people discover what they are missing. PMID:27965198

The association between intelligence and telomere length: a longitudinal population based study.

Directory of Open Access Journals (Sweden)

Eva M Kingma

Full Text Available Low intelligence has been associated with poor health and mortality, but underlying mechanisms remain obscure. We hypothesized that low intelligence is associated with accelerated biological ageing as reflected by telomere length; we suggested potential mediation of this association by unhealthy behaviors and low socioeconomic position. The study was performed in a longitudinal population-based cohort study of 895 participants (46.8% males. Intelligence was measured with the Generalized Aptitude-Test Battery at mean age 52.8 years (33-79 years, SD=11.3. Leukocyte telomere length was measured by PCR. Lifestyle and socioeconomic factors were assessed using written self-report measures. Linear regression analyses, adjusted for age, sex, and telomere length measured at the first assessment wave (T1, showed that low intelligence was associated with shorter leukocyte telomere length at approximately 2 years follow-up (beta= .081, t=2.160, p= .031. Nearly 40% of this association was explained by an unhealthy lifestyle, while low socioeconomic position did not add any significant mediation. Low intelligence may be a risk factor for accelerated biological ageing, thereby providing an explanation for its association with poor health and mortality.

Genome-wide association study of the four-constitution medicine.

Science.gov (United States)

Yin, Chang Shik; Park, Hi Joon; Chung, Joo-Ho; Lee, Hye-Jung; Lee, Byung-Cheol

2009-12-01

Four-constitution medicine (FCM), also known as Sasang constitutional medicine, and the heritage of the long history of individualized acupuncture medicine tradition, is one of the holistic and traditional systems of constitution to appraise and categorize individual differences into four major types. This study first reports a genome-wide association study on FCM, to explore the genetic basis of FCM and facilitate the integration of FCM with conventional individual differences research. Healthy individuals of the Korean population were classified into the four constitutional types (FCTs). A total of 353,202 single nucleotide polymorphisms (SNPs) were typed using whole genome amplified samples, and six-way comparison of FCM types provided lists of significantly differential SNPs. In one-to-one FCT comparisons, 15,944 SNPs were significantly differential, and 5 SNPs were commonly significant in all of the three comparisons. In one-to-two FCT comparisons, 22,616 SNPs were significantly differential, and 20 SNPs were commonly significant in all of the three comparison groups. This study presents the association between genome-wide SNP profiles and the categorization of the FCM, and it could further provide a starting point of genome-based identification and research of the constitutions of FCM.

Molecular evaluation of genetic diversity and association studies in ...

Indian Academy of Sciences (India)

Molecular evaluation of genetic diversity and association studies in rice. (Oryza sativa L.) C. Vanniarajan, K. K. Vinod and Andy Pereira. J. Genet. 91, 9–19. Table 1. Chromosome-wise distribution of SSR alleles and their number (k), polymorphic information content (PIC) and allele discrimination index (Dm). Chromosome.

Association between erectile dysfunction and chronic periodontitis: a clinical study.

Science.gov (United States)

Uppal, Ranjit Singh; Bhandari, Rajat; Singh, Karanparkash

2014-01-01

In recent years, evidence has come forth supporting the notion that localized infectious diseases such as periodontal disease may indeed influence a number of systemic diseases. Erectile dysfunction (ED) and chronic periodontitis have common risk factors such as diabetes mellitus, cardiac diseases and smoking etc. The aim was to evaluate the periodontal status of the subjects suffering from ED and to find association between vasculogenic ED and chronic periodontitis, if any. A total of 53 subjects suffering from vasculogenic ED were enrolled for the study and were divided into three groups on the basis of severity of ED. The clinical (probing pocket depth) and radiographic parameters (alveolar bone loss) were recorded and periodontal status of three groups was evaluated, compared and an attempt was made to find an association between ED and chronic periodontitis. Karl Pearson's correlation was used to assess an association between the two conditions. One-way ANOVA and Scheffe's test were used to find the significant difference of chronic periodontitis with severity of ED. Karl Pearson's correlation was used to find an association between chronic periodontitis and ED. Statistically significant mean differences of 1.73 mm, 0.56 mm and 1.17 mm were recorded when comparison was made among Group I and III, Group I and II and Group II and III, respectively. Mean differences in bone loss among three groups were also statistically significant. Both the diseases were positively correlated to each other. It may be concluded that chronic periodontitis and ED are associated with each other. However, further large scale studies with confounder analysis and longitudinal follow-up are warranted to explore the link between these two diseases.

Savannah River Site: Canyons and associated facilities utilization study

International Nuclear Information System (INIS)

Ellison, D.; Dickenson, J.

1995-01-01

The Westinghouse Savannah River Company was asked by the U.S. Department of Energy (DOE) to study options for utilization of Savannah River Site (SRS) Canyons and Associated Facilities to support existing and potential future material stabilization and/or disposition missions. This report is WSRC's response to that request. It includes: (1) A compilation of pending DOE material stabilization and/or disposition decisions involving utilization of SRS canyons and associated facilities, including discussion of quantities and expected availability of materials for which SRS handling and/or processing capability is a reasonable alternative under consideration. (2) A description of SRS canyons and associated facilities affected by pending DOE material stabilization and/or disposition decisions, including discussion of material handling and/or processing capabilities and capacities. (3) A comparative evaluation of three proposed scenarios for SRS canyon utilization with respect to startup and operating schedules; annual and life cycle costs; impacts on completion of commitments in the DOE Implementation Plan (IP) for Defense Nuclear Facilities Safety Board (DNFSB) Recommendation 94-1; SRS ability to support alternatives under consideration in pending DOE materials stabilization and/or disposition decisions; and timing for potential transition to deactivation. (4) The sensitivity of the comparative evaluation of the three canyon utilization scenarios to the effect of the selection of other alternatives for individual stabilization missions or individual new missions. Briefings on the scope of this study have been presented to key representatives of several SRS public stakeholder groups. Briefings on the major conclusions from this study have been presented to WSRC Management, DOE-SR, EM-60, EM-1, and the DNFSB

Anterior cervical spine surgery-associated complications in a retrospective case-control study

OpenAIRE

Tasiou, Anastasia; Giannis, Theofanis; Brotis, Alexandros G.; Siasios, Ioannis; Georgiadis, Iordanis; Gatos, Haralampos; Tsianaka, Eleni; Vagkopoulos, Konstantinos; Paterakis, Konstantinos; Fountas, Kostas N.

2017-01-01

Anterior cervical spine procedures have been associated with satisfactory outcomes. However, the occurrence of troublesome complications, although uncommon, needs to be taken into consideration. The purpose of our study was to assess the actual incidence of anterior cervical spine procedure-associated complications and identify any predisposing factors. A total of 114 patients undergoing anterior cervical procedures over a 6-year period were included in our retrospective, case-control study. ...

Association between bullous pemphigoid and neurologic diseases: a case-control study.

Science.gov (United States)

Casas-de-la-Asunción, E; Ruano-Ruiz, J; Rodríguez-Martín, A M; Vélez García-Nieto, A; Moreno-Giménez, J C

2014-11-01

In the past 10 years, bullous pemphigoid has been associated with other comorbidities and neurologic and psychiatric conditions in particular. Case series, small case-control studies, and large population-based studies in different Asian populations, mainland Europe, and the United Kingdom have confirmed this association. However, no data are available for the Spanish population. This was an observational, retrospective, case-control study with 1:2 matching. Fifty-four patients with bullous pemphigoid were selected. We compared the percentage of patients in each group with concurrent neurologic conditions, ischemic heart disease, diabetes, chronic obstructive pulmonary disease, and solid tumors using univariate logistic regression. An association model was constructed with conditional multiple logistic regression. The case group had a significantly higher percentage of patients with cerebrovascular accident and/or transient ischemic attack (odds ratio [OR], 3.06; 95% CI, 1.19-7.87], dementia (OR, 5.52; 95% CI, 2.19-13.93), and Parkinson disease (OR, 5; 95% CI, 1.57-15.94). A significantly higher percentage of cases had neurologic conditions (OR, 6.34; 95% CI, 2.89-13.91). Dementia and Parkinson disease were independently associated with bullous pemphigoid in the multivariate analysis. Patients with bullous pemphigoid have a higher frequency of neurologic conditions. Copyright © 2013 Elsevier España, S.L.U. and AEDV. All rights reserved.

16S rRNA gene-based association study identified microbial taxa associated with pork intramuscular fat content in feces and cecum lumen.

Science.gov (United States)

Fang, Shaoming; Xiong, Xingwei; Su, Ying; Huang, Lusheng; Chen, Congying

2017-07-19

Intramuscular fat (IMF) that deposits among muscle fibers or within muscle cells is an important meat quality trait in pigs. Previous studies observed the effects of dietary nutrients and additives on improving the pork IMF. Gut microbiome plays an important role in host metabolism and energy harvest. Whether gut microbiota exerts effect on IMF remains unknown. In this study, we investigated the microbial community structure of 500 samples from porcine cecum and feces using high-throughput 16S rRNA gene sequencing. We found that phylogenetic composition and potential function capacity of microbiome varied between two types of samples. Bacteria wide association study identified 119 OTUs significantly associated with IMF in the two types of samples (FDR microbiome associated with IMF might be caused by the IMF-associated microbial taxa. This study firstly evaluated the contribution of gut microbiome to porcine IMF content. The results presented a potential capacity for improving IMF through modulating gut microbiota.

An efficient Bayesian meta-analysis approach for studying cross-phenotype genetic associations.

Directory of Open Access Journals (Sweden)

Arunabha Majumdar

2018-02-01

Full Text Available Simultaneous analysis of genetic associations with multiple phenotypes may reveal shared genetic susceptibility across traits (pleiotropy. For a locus exhibiting overall pleiotropy, it is important to identify which specific traits underlie this association. We propose a Bayesian meta-analysis approach (termed CPBayes that uses summary-level data across multiple phenotypes to simultaneously measure the evidence of aggregate-level pleiotropic association and estimate an optimal subset of traits associated with the risk locus. This method uses a unified Bayesian statistical framework based on a spike and slab prior. CPBayes performs a fully Bayesian analysis by employing the Markov Chain Monte Carlo (MCMC technique Gibbs sampling. It takes into account heterogeneity in the size and direction of the genetic effects across traits. It can be applied to both cohort data and separate studies of multiple traits having overlapping or non-overlapping subjects. Simulations show that CPBayes can produce higher accuracy in the selection of associated traits underlying a pleiotropic signal than the subset-based meta-analysis ASSET. We used CPBayes to undertake a genome-wide pleiotropic association study of 22 traits in the large Kaiser GERA cohort and detected six independent pleiotropic loci associated with at least two phenotypes. This includes a locus at chromosomal region 1q24.2 which exhibits an association simultaneously with the risk of five different diseases: Dermatophytosis, Hemorrhoids, Iron Deficiency, Osteoporosis and Peripheral Vascular Disease. We provide an R-package 'CPBayes' implementing the proposed method.

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

DEFF Research Database (Denmark)

O'Dushlaine, Colm; Rossin, Lizzy; Lee, Phil H.

2015-01-01

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from ...

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

NARCIS (Netherlands)

O'Dushlaine, Colm; Rossin, Lizzy; Lee, Phil H.; Duncan, Laramie; Parikshak, Neelroop N.; Newhouse, Stephen; Ripke, Stephan; Neale, Benjamin M.; Purcell, Shaun M.; Posthuma, Danielle; Nurnberger, John I.; Lee, S. Hong; Faraone, Stephen V.; Perlis, Roy H.; Mowry, Bryan J.; Thapar, Anita; Goddard, Michael E.; Witte, John S.; Absher, Devin; Agartz, Ingrid; Akil, Huda; Amin, Farooq; Andreassen, Ole A.; Anjorin, Adebayo; Anney, Richard; Anttila, Verneri; Arking, Dan E.; Asherson, Philip; Azevedo, Maria H.; Backlund, Lena; Badner, Judith A.; Bailey, Anthony J.; Banaschewski, Tobias; Barchas, Jack D.; Barnes, Michael R.; Barrett, Thomas B.; Bass, Nicholas; Battaglia, Agatino; Bauer, Michael; Bayes, Monica; Bellivier, Frank; Bergen, Sarah E.; Berrettini, Wade; Betancur, Catalina; Bettecken, Thomas; Biederman, Joseph; Binder, Elisabeth B.; Bruggeman, Richard; Nolen, Willem A.; Penninx, Brenda W.

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

NARCIS (Netherlands)

O'Dushlaine, Colm; Rossin, Lizzy; Lee, Phil H.; Duncan, Laramie; Parikshak, Neelroop N.; Newhouse, Stephen; Ripke, Stephan; Neale, Benjamin M.; Purcell, Shaun M.; Posthuma, Danielle; Nurnberger, John I.; Lee, S. Hong; Faraone, Stephen V.; Perlis, Roy H.; Mowry, Bryan J.; Thapar, Anita; Goddard, Michael E.; Witte, John S.; Absher, Devin; Agartz, Ingrid; Akil, Huda; Amin, Farooq; Andreassen, Ole A.; Anjorin, Adebayo; Anney, Richard; Anttila, Verneri; Arking, Dan E.; Asherson, Philip; Azevedo, Maria H.; Backlund, Lena; Badner, Judith A.; Bailey, Anthony J.; Banaschewski, Tobias; Barchas, Jack D.; Barnes, Michael R.; Barrett, Thomas B.; Bass, Nicholas; Battaglia, Agatino; Bauer, Michael; Bayés, Mònica; Bellivier, Frank; Bergen, Sarah E.; Berrettini, Wade; Betancur, Catalina; Bettecken, Thomas; Biederman, Joseph; Binder, Elisabeth B.; Black, Donald W.; de Haan, Lieuwe; Linszen, Don H.

2015-01-01

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.

Science.gov (United States)

Hoffmann, Sarah; Harms, Hendrik; Ulm, Lena; Nabavi, Darius G; Mackert, Bruno-Marcel; Schmehl, Ingo; Jungehulsing, Gerhard J; Montaner, Joan; Bustamante, Alejandro; Hermans, Marcella; Hamilton, Frank; Göhler, Jos; Malzahn, Uwe; Malsch, Carolin; Heuschmann, Peter U; Meisel, Christian; Meisel, Andreas

2017-12-01

Stroke-associated pneumonia is a frequent complication after stroke associated with poor outcome. Dysphagia is a known risk factor for stroke-associated pneumonia but accumulating evidence suggests that stroke induces an immunodepressive state increasing susceptibility for stroke-associated pneumonia. We aimed to confirm that stroke-induced immunodepression syndrome is associated with stroke-associated pneumonia independently from dysphagia by investigating the predictive properties of monocytic HLA-DR expression as a marker of immunodepression as well as biomarkers for inflammation (interleukin-6) and infection (lipopolysaccharide-binding protein). This was a prospective, multicenter study with 11 study sites in Germany and Spain, including 486 patients with acute ischemic stroke. Daily screening for stroke-associated pneumonia, dysphagia and biomarkers was performed. Frequency of stroke-associated pneumonia was 5.2%. Dysphagia and decreased monocytic HLA-DR were independent predictors for stroke-associated pneumonia in multivariable regression analysis. Proportion of pneumonia ranged between 0.9% in the higher monocytic HLA-DR quartile (≥21,876 mAb/cell) and 8.5% in the lower quartile (≤12,369 mAb/cell). In the presence of dysphagia, proportion of pneumonia increased to 5.9% and 18.8%, respectively. Patients without dysphagia and normal monocytic HLA-DR expression had no stroke-associated pneumonia risk. We demonstrate that dysphagia and stroke-induced immunodepression syndrome are independent risk factors for stroke-associated pneumonia. Screening for immunodepression and dysphagia might be useful for identifying patients at high risk for stroke-associated pneumonia.

Genome-wide association study identifies five new schizophrenia loci

NARCIS (Netherlands)

Ripke, S.; Sanders, A. R.; Kendler, K. S.; Levinson, D. F.; Sklar, P.; Holmans, P. A.; Lin, D. Y.; Duan, J.; Ophoff, R. A.; Andreassen, O. A.; Scolnick, E.; Cichon, S.; St Clair, D.; Corvin, A.; Gurling, H.; Werge, T.; Rujescu, D.; Blackwood, D. H.; Pato, C. N.; Malhotra, A. K.; Purcell, S.; Dudbridge, F.; Neale, B. M.; Rossin, L.; Visscher, P. M.; Posthuma, D.; Ruderfer, D. M.; Fanous, A.; Stefansson, H.; Steinberg, S.; Mowry, B. J.; Golimbet, V.; de Hert, M.; Jonsson, E. G.; Bitter, I.; Pietilainen, O. P.; Collier, D. A.; Tosato, S.; Agartz, I.; Albus, M.; Alexander, M.; Amdur, R. L.; Amin, F.; Bass, N.; Bergen, S. E.; Black, D. W.; Borglum, A. D.; Brown, M. A.; Bruggeman, R.; Buccola, N. G.; Byerley, W. F.; Cahn, W.; Cantor, R. M.; Carr, V. J.; Catts, S. V.; Choudhury, K.; Cloninger, C. R.; Cormican, P.; Craddock, N.; Danoy, P. A.; Datta, S.; de Haan, L.; Demontis, D.; Dikeos, D.; Djurovic, S.; Donnely, P.; Donohoe, G.; Duong, L.; Dwyer, S.; Fink-Jensen, A.; Freedman, R.; Freimer, N. B.; Friedl, M.; Georgieva, L.; Giegling, I.; Gill, M.; Glenthoj, B.; Godard, S.; Hamshere, M.; Hansen, M.; Hartmann, A. M.; Henskens, F. A.; Hougaard, D. M.; Hultman, C. M.; Ingason, A.; Jablensky, A. V.; Jakobsen, K. D.; Jay, M.; Jurgens, G.; Kahn, R. S.; Keller, M. C.; Kenis, G.; Kenny, E.; Kim, Y.; Kirov, G. K.; Konnerth, H.; Konte, B.; Krabbendam, L.; Krasucki, R.; Lasseter, V. K.; Laurent, C.; Lawrence, J.; Lencz, T.; Lerer, F. B.; Liang, K. Y.; Lichtenstein, P.; Lieberman, J. A.; Linszen, D. H.; Lonnqvist, J.; Loughland, C. M.; Maclean, A. W.; Maher, B. S.; Maier, W.; Mallet, J.; Malloy, P.; Mattheisen, M.; Mattingsdal, M.; McGhee, K. A.; McGrath, J. J.; McIntosh, A.; McLean, D. E.; McQuillin, A.; Melle, I.; Michie, P. T.; Milanova, V.; Morris, D. W.; Mors, O.; Mortensen, P. B.; Moskvina, V.; Muglia, P.; Myin-Germeys, I.; Nertney, D. A.; Nestadt, G.; Nielsen, J.; Nikolov, I.; Nordentoft, M.; Norton, N.; Nothen, M. M.; O'Dushlaine, C. T.; Olincy, A.; Olsen, L.; O'Neill, F. A.; Orntoft, T. F.; Owen, M. J.; Pantelis, C.; Papadimitriou, G.; Pato, M. T.; Peltonen, L.; Petursson, H.; Pickard, B.; Pimm, J.; Pulver, A. E.; Puri, V.; Quested, D.; Quinn, E. M.; Rasmussen, H. B.; Rethelyi, J. M.; Ribble, R.; Rietschel, M.; Riley, B. P.; Ruggeri, M.; Schall, U.; Schulze, T. G.; Schwab, S. G.; Scott, R. J.; Shi, J.; Sigurdsson, E.; Silvermann, J. M.; Spencer, C. C.; Stefansson, K.; Strange, A.; Strengman, E.; Stroup, T. S.; Suvisaari, J.; Terenius, L.; Thirumalai, S.; Thygesen, J. H.; Timm, S.; Toncheva, D.; van den Oord, E.; van Os, J.; van Winkel, R.; Veldink, J.; Walsh, D.; Wang, A. G.; Wiersma, D.; Wildenauer, D. B.; Williams, H. J.; Williams, N. M.; Wormley, B.; Zammit, S.; Sullivan, P. F.; O'Donovan, M. C.; Daly, M. J.; Gejman, P. V.

2011-01-01

We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded

The Application of Hermeneutical Analysis to Research on the Cold War in Soviet Animation Media Texts from the Second Half of the 1940s

Science.gov (United States)

Fedorov, A. V.

2015-01-01

The Cold War era, which spawned a mutual ideological confrontation between communist and capitalist countries, left its mark on all categories of media texts, including cartoons and animations. Cartoons were used by the authorities as tools for delivering the necessary confrontational ideological content in an attractive folkloric, fairy-tale…

Arkansas Reference Sources. Bibliographic Series No. 26.

Science.gov (United States)

Ahrens, Joan; Roberts, Joan

Varied sources for information on Arkansas held by the Arkansas University library are listed. Bibliographies and indexes of Arkansas publications are included, as well as materials dealing with the state's folklore and literature, arts and humanities, government and law, business and economics, social conditions, labor, history and biography,…

The tradition of intertextuality in the author's tale of the material of the Italian language

Directory of Open Access Journals (Sweden)

Маргарита Евгеньевна Каскова

2012-03-01

Full Text Available The article discussed the problem of drawing and interpretation of folklore stories by Italian authors. The tradition of intertextuality in the author's tale can be traced to ancient times and is regarded as an example of works by writers Fedro, S. Venni, C. Collodi, G. Rodari.

Choosing a Pet

Institute of Scientific and Technical Information of China (English)

无

2011-01-01

THE capital boasts countless markets of all kinds,but some of its insect,bird and pet markets immortalize Beijing culture and folkloric traditions.Don’t miss it! The Huasheng Tianqiao Market,south of the famous Panjiayuan Antique Market, was moved a few years ago and rebuilt in the

Science and Sanity in Special Education.

Science.gov (United States)

Dammann, James E.; Vaughn, Sharon

2001-01-01

This article describes the usefulness of a scientific approach to improving knowledge and practice in special education. Of four approaches to knowledge (superstition, folklore, craft, and science), craft and science are supported and implications for special education drawn including the need to bridge the gulf between research knowledge and…

Multicultural Bibliography: Kindergarten-Grade 8 Library Books.

Science.gov (United States)

San Diego County Office of Education, CA.

This annotated bibliography includes approximately 375 elementary-level books on history, biography, folklore, fiction, poetry, arts and crafts, and contemporary life of Blacks, Native Americans, Pan Asian Americans, Puerto Ricans, and other ethnic groups. The books cited are deemed to be non-stereotyped and appropriate for developing a…

Complexities of Vietnamese Femininities: A Resource for Rethinking Women's University Leadership Practices

Science.gov (United States)

Do, Van Hanh Thi; Brennan, Marie

2015-01-01

This paper develops a dialogical encounter between northern-inspired theorisations of gender and Vietnam's historical and cultural differentiation identified through the presence of matriarchy in ancient societies and its popularity in folklore and contemporary politics. The article draws on interviews with 12 senior women from 8 universities in…

Sociodemographic Moderators of Environment-Physical Activity Associations: Results From the International Prevalence Study.

Science.gov (United States)

Perez, Lilian G; Conway, Terry L; Bauman, Adrian; Kerr, Jacqueline; Elder, John P; Arredondo, Elva M; Sallis, James F

2018-01-01

Associations between the built environment and physical activity (PA) may vary by sociodemographic factors. However, such evidence from international studies is limited. This study tested the moderating effects of sociodemographic factors on associations between perceived environment and self-reported total PA among adults from the International Prevalence Study. Between 2002 and 2003, adults from 9 countries (N = 10,258) completed surveys assessing total PA (International Physical Activity Questionnaire-short), perceived environment, and sociodemographics (age, gender, and education). Total PA was dichotomized as meeting/not meeting (a) high PA levels and (b) minimum PA guidelines. Logistic models tested environment by sociodemographic interactions (24 total). Education and gender moderated the association between safety from crime and meeting high PA levels (interaction P environment-PA associations. International efforts to improve built environments are needed to promote health-enhancing PA and maintain environmental sustainability.

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.

Science.gov (United States)

Mansour, Hader A; Talkowski, Michael E; Wood, Joel; Chowdari, Kodavali V; McClain, Lora; Prasad, Konasale; Montrose, Debra; Fagiolini, Andrea; Friedman, Edward S; Allen, Michael H; Bowden, Charles L; Calabrese, Joseph; El-Mallakh, Rif S; Escamilla, Michael; Faraone, Stephen V; Fossey, Mark D; Gyulai, Laszlo; Loftis, Jennifer M; Hauser, Peter; Ketter, Terence A; Marangell, Lauren B; Miklowitz, David J; Nierenberg, Andrew A; Patel, Jayendra; Sachs, Gary S; Sklar, Pamela; Smoller, Jordan W; Laird, Nan; Keshavan, Matcheri; Thase, Michael E; Axelson, David; Birmaher, Boris; Lewis, David; Monk, Tim; Frank, Ellen; Kupfer, David J; Devlin, Bernie; Nimgaonkar, Vishwajit L

2009-11-01

Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders. We assayed 276 publicly available 'tag' single nucleotide polymorphisms (SNPs) at 21 circadian genes among 523 patients with BPI, 527 patients with SZ/SZA, and 477 screened adult controls. Detected associations were evaluated in relation to two published genome-wide association studies (GWAS). Using gene-based tests, suggestive associations were noted between EGR3 and BPI (p = 0.017), and between NPAS2 and SZ/SZA (p = 0.034). Three SNPs were associated with both sets of disorders (NPAS2: rs13025524 and rs11123857; RORB: rs10491929; p < 0.05). None of the associations remained significant following corrections for multiple comparisons. Approximately 15% of the analyzed SNPs overlapped with an independent study that conducted GWAS for BPI; suggestive overlap between the GWAS analyses and ours was noted at ARNTL. Several suggestive, novel associations were detected with circadian genes and BPI and SZ/SZA, but the present analyses do not support associations with common polymorphisms that confer risk with odds ratios greater than 1.5. Additional analyses using adequately powered samples are warranted to further evaluate these results.

Infrared study of new star cluster candidates associated to dusty globules

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Soto King, P.; Barbá, R.; Roman-Lopes, A.; Jaque, M.; Firpo, V.; Nilo, J. L.; Soto, M.; Minniti, D.

2014-10-01

We present results from a study of a sample of small star clusters associated to dusty globules and bright-rimmed clouds that have been observed under ESO/Chile public infrared survey Vista Variables in the Vía Láctea (VVV). In this short communication, we analyse the near-infrared properties of a set of four small clusters candidates associated to dark clouds. This sample of clusters associated to dusty globules are selected from the new VVV stellar cluster candidates developed by members of La Serena VVV Group (Barbá et al. 2014). Firstly, we are producing color-color and color-magnitude diagrams for both, cluster candidates and surrounding areas for comparison through PSF photometry. The cluster positions are determined from the morphology on the images and also from the comparison of the observed luminosity function for the cluster candidates and the surrounding star fields. Now, we are working in the procedures to establish the full sample of clusters to be analyzed and methods for subtraction of the star field contamination. These clusters associated to dusty globules are simple laboratories to study the star formation relatively free of the influence of large star-forming regions and populous clusters, and they will be compared with those clusters associated to bright-rimmed globules, which are influenced by the energetic action of nearby O and B massive stars.

Epigenome-wide association study of metabolic syndrome in African-American adults.

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Akinyemiju, Tomi; Do, Anh N; Patki, Amit; Aslibekyan, Stella; Zhi, Degui; Hidalgo, Bertha; Tiwari, Hemant K; Absher, Devin; Geng, Xin; Arnett, Donna K; Irvin, Marguerite R

2018-01-01

The high prevalence of obesity among US adults has resulted in significant increases in associated metabolic disorders such as diabetes, dyslipidemia, and high blood pressure. Together, these disorders constitute metabolic syndrome, a clinically defined condition highly prevalent among African-Americans. Identifying epigenetic alterations associated with metabolic syndrome may provide additional information regarding etiology beyond current evidence from genome-wide association studies. Data on metabolic syndrome and DNA methylation was assessed on 614 African-Americans from the Hypertension Genetic Epidemiology Network (HyperGEN) study. Metabolic syndrome was defined using the joint harmonized criteria, and DNA methylation was assessed using the Illumina HumanMethylation450K Bead Chip assay on DNA extracted from buffy coat. Linear mixed effects regression models were used to examine the association between CpG methylation at > 450,000 CpG sites and metabolic syndrome adjusted for study covariates. Replication using DNA from a separate sample of 69 African-Americans, as well as meta-analysis combining both cohorts, was conducted. Two differentially methylated CpG sites in the IGF2BP1 gene on chromosome 17 (cg06638433; p value = 3.10 × 10 - 7 ) and the ABCG1 gene on chromosome 21 (cg06500161; p value = 2.60 × 10 - 8 ) were identified. Results for the ABCG1 gene remained statistically significant in the replication dataset and meta-analysis. Metabolic syndrome was consistently associated with increased methylation in the ABCG1 gene in the discovery and replication datasets, a gene that encodes a protein in the ATP-binding cassette transporter family and is involved in intra- and extra-cellular signaling and lipid transport.

Examples of the Motif of the Shrew in European Literature and Film

OpenAIRE

Vasvári, Louise O.

2001-01-01

In her article "Examples of the Motif of the Shrew in European Literature and Film" Louise O. Vasvári presents the shrew-taming story as a masterplot of both Eastern and Western folklore and literature concerned with establishing the appropriate power dynamic between a married couple. Vasvári firts reviews the comparative groundwork of the story she has documented in her earlier studies of the topic. In addition to tracing the bundle of motifs that make up the shrew story from medieval Arabic...

ACADEMIC GENEALOGIES WITH RESPECT TO NARRATIVE IN HUMAN AND SOCIAL SCIENCES AND THEIR IMPLICATION FOR PUBLIC POLICIES

Science.gov (United States)

Fujii, Satoshi; Hasegawa, Taiki; Nakano, Takeshi; Hatori, Tsuyoshi

In human and society science, narrative is regarded as an important issue to understand dynamic actions of human being and society. Therefore, narrative is also expected to be important for public policies that try to improve dynamic actions of human being and society. In th is study, we review academic genealogies with respect to narratives including western philosophy, hermeneutics, historical science, historical philosophy, literary criticism, clinical psychology and sociology, narrative psychology and folklore. Then we discuss how narrative can be pragmatically applied for public policies.

Heritability and confirmation of genetic association studies for childhood asthma in twins.

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Ullemar, V; Magnusson, P K E; Lundholm, C; Zettergren, A; Melén, E; Lichtenstein, P; Almqvist, C

2016-02-01

Although the genetics of asthma has been extensively studied using both quantitative and molecular genetic analysis methods, both approaches lack studies specific to the childhood phenotype and including other allergic diseases. This study aimed to give specific estimates for the heritability of childhood asthma and other allergic diseases, to attempt to replicate findings from genomewide association studies (GWAS) for childhood asthma and to test the same variants against other allergic diseases. In a cohort of 25 306 Swedish twins aged 9 or 12 years, data on asthma were available from parental interviews and population-based registers. The interviews also inquired about wheeze, hay fever, eczema, and food allergy. Through structural equation modeling, the heritability of all phenotypes was calculated. A subset of 10 075 twins was genotyped for 16 single nucleotide polymorphisms (SNPs) selected from previous GWAS; these were first tested for association with asthma and significant findings also against the other allergic diseases. The heritability of any childhood asthma was 0.82 (95% CI 0.79-0.85). For the other allergic diseases, the range was approximately 0.60-0.80. Associations for six SNPs with asthma were replicated, including rs2305480 in the GSDMB gene (OR 0.80, 95% CI 0.74-0.86, P = 1.5*10(-8) ; other significant associations all below P = 3.5*10(-4) ). Of these, only rs3771180 in IL1RL1 was associated with any other allergic disease (for hay fever, OR 0.64, 95% CI 0.53-0.77, P = 2.5*10(-6) ). Asthma and allergic diseases of childhood are highly heritable, and these high-risk genetic variants associated specifically with childhood asthma, except for one SNP shared with hay fever. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Temporomandibular disorders are differentially associated with headache diagnoses: a controlled study.

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Gonçalves, Daniela A G; Camparis, Cinara M; Speciali, José G; Franco, Ana L; Castanharo, Sabrina M; Bigal, Marcelo E

2011-09-01

Temporomandibular disorders (TMDs) are considered to be comorbid with headaches. Earlier population studies have suggested that TMD may also be a risk factor for migraine progression. If that is true, TMD should be associated with specific headache syndromes (eg, migraine and chronic migraine), but not with headaches overall. Accordingly, our aim was to explore the relationship between TMD subtypes and severity with primary headaches in a controlled clinical study. The sample consisted of 300 individuals. TMDs were assessed using the Research Diagnostic Criteria for TMD, and primary headache was classified according to International Classification for Headache Disorders-2. Univariate and multivariate models assessed headache diagnoses and frequency as a function of the parameters of TMD. Relative to those without TMD, individuals with myofascial TMD were significantly more likely to have chronic daily headaches (CDHs) [relative risk (RR)=7.8; 95% confidence interval (CI), 3.1-19.6], migraine (RR=4.4; 95% CI, 1.7-11.7), and episodic tension-type headache (RR=4.4; 95% CI, 1.5-12.6). Grade of TMD pain was associated with increased odds of CDH (Pheadache (Pheadache frequency. In multivariate analyses, TMD was associated with migraine and CDH (P=0.001). Painful TMD (P=0.0034) and grade of TMD pain (Pheadache frequency. TMD, TMD subtypes, and TMD severity are independently associated with specific headache syndromes and with headache frequency. This differential association suggests that the presence of central facilitation of nociceptive inputs may be of importance, as positive association was observed only when muscular TMD pain was involved.

Association of Facebook Use With Compromised Well-Being: A Longitudinal Study.

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Shakya, Holly B; Christakis, Nicholas A

2017-02-01

Face-to-face social interactions enhance well-being. With the ubiquity of social media, important questions have arisen about the impact of online social interactions. In the present study, we assessed the associations of both online and offline social networks with several subjective measures of well-being. We used 3 waves (2013, 2014, and 2015) of data from 5,208 subjects in the nationally representative Gallup Panel Social Network Study survey, including social network measures, in combination with objective measures of Facebook use. We investigated the associations of Facebook activity and real-world social network activity with self-reported physical health, self-reported mental health, self-reported life satisfaction, and body mass index. Our results showed that overall, the use of Facebook was negatively associated with well-being. For example, a 1-standard-deviation increase in "likes clicked" (clicking "like" on someone else's content), "links clicked" (clicking a link to another site or article), or "status updates" (updating one's own Facebook status) was associated with a decrease of 5%-8% of a standard deviation in self-reported mental health. These associations were robust to multivariate cross-sectional analyses, as well as to 2-wave prospective analyses. The negative associations of Facebook use were comparable to or greater in magnitude than the positive impact of offline interactions, which suggests a possible tradeoff between offline and online relationships. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Evolutionary Meta-Analysis of Association Studies Reveals Ancient Constraints Affecting Disease Marker Discovery

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Dudley, Joel T.; Chen, Rong; Sanderford, Maxwell; Butte, Atul J.; Kumar, Sudhir

2012-01-01

Genome-wide disease association studies contrast genetic variation between disease cohorts and healthy populations to discover single nucleotide polymorphisms (SNPs) and other genetic markers revealing underlying genetic architectures of human diseases. Despite scores of efforts over the past decade, many reproducible genetic variants that explain substantial proportions of the heritable risk of common human diseases remain undiscovered. We have conducted a multispecies genomic analysis of 5,831 putative human risk variants for more than 230 disease phenotypes reported in 2,021 studies. We find that the current approaches show a propensity for discovering disease-associated SNPs (dSNPs) at conserved genomic positions because the effect size (odds ratio) and allelic P value of genetic association of an SNP relates strongly to the evolutionary conservation of their genomic position. We propose a new measure for ranking SNPs that integrates evolutionary conservation scores and the P value (E-rank). Using published data from a large case-control study, we demonstrate that E-rank method prioritizes SNPs with a greater likelihood of bona fide and reproducible genetic disease associations, many of which may explain greater proportions of genetic variance. Therefore, long-term evolutionary histories of genomic positions offer key practical utility in reassessing data from existing disease association studies, and in the design and analysis of future studies aimed at revealing the genetic basis of common human diseases. PMID:22389448

Prioritization of arbitrary faces associated to self: An EEG study.

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Mateusz Woźniak

Full Text Available Behavioral and neuroimaging studies have demonstrated that people process preferentially self-related information such as an image of their own face. Furthermore, people rapidly incorporate stimuli into their self-representation even if these stimuli do not have an intrinsic relation to self. In the present study, we investigated the time course of the processes involved in preferential processing of self-related information. In two EEG experiments three unfamiliar faces were identified with verbal labels as either the participant, a friend, or a stranger. Afterwards, participants judged whether two stimuli presented in succession (ISI = 1500ms matched. In experiment 1, faces were followed by verbal labels and in experiment 2, labels were followed by faces. Both experiments showed the same pattern of behavioral and electrophysiological results. If the first stimulus (face or label was associated with self, reaction times were faster and the late frontal positivity following the first stimulus was more pronounced. The self-association of the second stimulus (label or face did not affect response times. However, the central-parietal P3 following presentation of the second stimulus was more pronounced when the second stimulus was preceded by self-related first stimulus. These results indicate that even unfamiliar faces that are associated to self can activate a self-representation. Once the self-representation has been activated the processing of ensuing stimuli is facilitated, irrespective of whether they are associated with the self.

Association between bacterial vaginosis and partner concurrency: a longitudinal study.

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Kenyon, Chris R; Buyze, Jozefien; Klebanoff, Mark; Brotman, Rebecca M

2018-02-01

The study aimed to test if there was an association between prevalent bacterial vaginosis (BV) and women reporting that their partner had other partners at the same time (partner concurrency). This association has not been assessed in a longitudinal cohort. The Longitudinal Study of Vaginal Flora recruited a cohort of 3620 non-pregnant women aged 15-44 years who presented for routine primary healthcare at 12 clinics in Birmingham, Alabama. Behavioural questionnaires and vaginal smears were obtained quarterly for a year and BV was defined by a Nugent score 7 or higher as well as Amsel criteria. Mixed effects logistic regression was used to assess the relationship between prevalent BV and reporting that one's partner had other partners in the preceding 3-6 months time interval. Nugent score prevalent BV was associated with both reporting that one's partner definitely (adjusted OR (aOR) 1.5; 95% CI 1.2 to 1.8) and possibly (aOR 1.5; 95% CI 1.2 to 1.8) engaged in partner concurrency in the preceding 3-6 months time period. Prevalent BV diagnosed by Amsel criteria was similar. A diagnosis of prevalent BV was associated with reporting that one's partner possibly or definitely engaged in partner concurrency. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Associations between faith, distress and mental adjustment--a Danish survivorship study.

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Johannessen-Henry, Christine Tind; Deltour, Isabelle; Bidstrup, Pernille Envold; Dalton, Susanne O; Johansen, Christoffer

2013-02-01

Several studies have suggested that religion and spirituality are important for overcoming psychological distress and adjusting mentally to cancer, but these studies did not differentiate between spiritual well-being and specific aspects of faith. We examined the extent to which spiritual well-being, the faith dimension of spiritual well-being and aspects of performed faith are associated with distress and mental adjustment among cancer patients. In a cross-sectional design, 1043 survivors of various cancers filled in a questionnaire on spiritual well-being (FACIT-Sp-12), specific aspects of faith ('belief in a god', 'belief in a god with whom I can talk' and 'experiences of god or a higher power'), religious community and church attendance (DUREL), distress (POMS-SF), adjustment to cancer (Mini-MAC) and sociodemographic factors. Linear regression models were used to analyze the associations between exposure (spiritual well-being and specific faith aspects) and outcome (distress and adjustment to cancer) with adjustment for age, gender, cancer diagnosis and physical and social well-being. Higher spiritual well-being was associated with less total distress (β = -0.79, CI -0.92; -0.66) and increased adjustment to cancer (fighting spirit, anxious preoccupation, helplessness-hopelessness). Specific aspects of faith were associated with high confusion-bewilderment and tension-anxiety, but also lower score on vigor-activity, and with higher anxious-preoccupation, both higher and lower cognitive avoidance, but also more fighting spirit. As hypothesized, spiritual well-being were associated with less distress and better mental adjustment. However, specific aspects of faith were both positively and negatively associated with distress and mental adjustment. The results illustrate the complexity of associations between spiritual well-being and specific aspects of faith with psychological function among cancer survivors.

A Retrospective Study on Magnitude and Factors Associated with ...

African Journals Online (AJOL)

Background: Anemia in the postnatal period is a common problem, which has been subject of research recently. Though, it is a common problem, it is a less researched topic in India. Hence, this study was undertaken. Aim: The aim was to know the clinic.social factors associated with anemia in the postpartum period.

Genome–wide association study of carcass weight in commercial Hanwoo cattle

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Edea, Zewdu; Jeoung, Yeong Ho; Shin, Sung-Sub; Ku, Jaeul; Seo, Sungbo; Kim, Il-Hoi; Kim, Sang-Wook

2018-01-01

Objective The objective of the present study was to validate genes and genomic regions associated with carcass weight using a low-density single nucleotide polymorphism (SNP) Chip in Hanwoo cattle breed. Methods Commercial Hanwoo steers (n = 220) were genotyped with 20K GeneSeek genomic profiler BeadChip. After applying the quality control of criteria of a call rate ≥90% and minor allele frequency (MAF) ≥0.01, a total of 15,235 autosomal SNPs were left for genome-wide association (GWA) analysis. The GWA tests were performed using single-locus mixed linear model. Age at slaughter was fitted as fixed effect and sire included as a covariate. The level of genome-wide significance was set at 3.28×10−6 (0.05/15,235), corresponding to Bonferroni correction for 15,235 multiple independent tests. Results By employing EMMAX approach which is based on a mixed linear model and accounts for population stratification and relatedness, we identified 17 and 16 loci significantly (pcarcass weight for the additive and dominant models, respectively. The second most significant (p = 0.000049) SNP (ARS-BFGL-NGS-28234) on bovine chromosome 4 (BTA4) at 21 Mb had an allele substitution effect of 43.45 kg. Some of the identified regions on BTA2, 6, 14, 22, and 24 were previously reported to be associated with quantitative trait loci for carcass weight in several beef cattle breeds. Conclusion This is the first genome-wide association study using SNP chips on commercial Hanwoo steers, and some of the loci newly identified in this study may help to better DNA markers that determine increased beef production in commercial Hanwoo cattle. Further studies using a larger sample size will allow confirmation of the candidates identified in this study. PMID:29103288

Association between phytosterol intake and colorectal cancer risk: a case-control study.

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Huang, Jing; Xu, Ming; Fang, Yu-Jing; Lu, Min-Shan; Pan, Zhi-Zhong; Huang, Wu-Qing; Chen, Yu-Ming; Zhang, Cai-Xia

2017-03-01

A study in rodent models showed that phytosterols protected against colon carcinogenesis, probably by inhibiting dysregulated cell cycle progression and inducing cellular apoptosis. However, epidemiological studies on the relationship between phytosterols and colorectal cancer risk are quite limited. The aim of this study was to investigate dietary phytosterol intake in relation to colorectal cancer risk in the Chinese population. A case-control study was conducted from July 2010 to June 2016, recruiting 1802 eligible colorectal cancer cases plus 1813 age (5-year interval) and sex frequency-matched controls. Dietary information was collected by using a validated FFQ. The OR and 95 % CI of colorectal cancer risk were assessed by multivariable logistic regression models. A higher total intake of phytosterols was found to be associated with a 50 % reduction in colorectal cancer risk. After adjusting for various confounders, the OR of the highest quartile intake compared with the lowest quartile intake was 0·50 (95 % CI 0·41, 0·61, P trendphytosterols. An inverse association was also found between the consumption of β-sitosterol, campesterol, campestanol and colorectal cancer risk. However, stigmasterol intake was related to an increased risk of colorectal cancer. No statistically significant association was found between β-sitostanol and colorectal cancer risk. Stratified analysis by sex showed that the positive association of stigmasterol intake with colorectal cancer risk was found only in women. These data indicated that the consumption of total phytosterols, β-sitosterol, campesterol and campestanol is inversely associated with colorectal cancer risk in a Chinese population.

Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits.

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Tamar Sofer

Full Text Available Admixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP, mean arterial pressure (MAP, and pulse pressure (PP, in a dataset of 12,116 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL. Hispanics/Latinos have three predominant ancestral populations (European, African, and Amerindian, for each of which we separately tested local ancestry intervals across the genome. We identified four regions that were significantly associated with a blood pressure trait at the genome-wide admixture mapping level. A 6p21.31 Amerindian ancestry association region has multiple known associations, but none explained the admixture mapping signal. We identified variants that completely explained this signal. One of these variants had p-values of 0.02 (MAP and 0.04 (SBP in replication testing in Pima Indians. A 11q13.4 Amerindian ancestry association region spans a variant that was previously reported (p-value = 0.001 in a targeted association study of Blood Pressure (BP traits and variants in the vitamin D pathway. There was no replication evidence supporting an association in the identified 17q25.3 Amerindian ancestry association region. For a region on 6p12.3, associated with African ancestry, we did not identify any candidate variants driving the association. It may be driven by rare variants. Whole genome sequence data may be necessary to fine map these association signals, which may contribute to disparities in BP traits between diverse populations.

Genome-wide association of lipid-lowering response to statins in combined study populations.

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Mathew J Barber

2010-03-01

Full Text Available Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies among individuals. To identify single nucleotide polymorphisms (SNPs contributing to this variation, we performed a combined analysis of genome-wide association (GWA results from three trials of statin efficacy.Bayesian and standard frequentist association analyses were performed on untreated and statin-mediated changes in LDL-cholesterol, total cholesterol, HDL-cholesterol, and triglyceride on a total of 3932 subjects using data from three studies: Cholesterol and Pharmacogenetics (40 mg/day simvastatin, 6 weeks, Pravastatin/Inflammation CRP Evaluation (40 mg/day pravastatin, 24 weeks, and Treating to New Targets (10 mg/day atorvastatin, 8 weeks. Genotype imputation was used to maximize genomic coverage and to combine information across studies. Phenotypes were normalized within each study to account for systematic differences among studies, and fixed-effects combined analysis of the combined sample were performed to detect consistent effects across studies. Two SNP associations were assessed as having posterior probability greater than 50%, indicating that they were more likely than not to be genuinely associated with statin-mediated lipid response. SNP rs8014194, located within the CLMN gene on chromosome 14, was strongly associated with statin-mediated change in total cholesterol with an 84% probability by Bayesian analysis, and a p-value exceeding conventional levels of genome-wide significance by frequentist analysis (P = 1.8 x 10(-8. This SNP was less significantly associated with change in LDL-cholesterol (posterior probability = 0.16, P = 4.0 x 10(-6. Bayesian analysis also assigned a 51% probability that rs4420638, located in APOC1 and near APOE, was associated with change in LDL-cholesterol.Using combined GWA analysis from three clinical trials involving nearly 4,000 individuals treated with simvastatin, pravastatin, or atorvastatin, we

Genome-wide association studies in economics and entrepreneurship research: promises and limitations

NARCIS (Netherlands)

Ph.D. Koellinger (Philipp); M.J.H.M. van der Loos (Matthijs); P.J.F. Groenen (Patrick); A.R. Thurik (Roy); F. Rivadeneira Ramirez (Fernando); F.J.A. van Rooij (Frank)

2010-01-01

textabstractThe recently developed genome-wide association study (GWAS) design enables the identification of genes specifically associated with economic outcomes such as occupational and other choices. This is a promising new approach for economics research which we aim to apply to the choice for

Multiple comparison procedures for neuroimaging genomewide association studies.

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Hua, Wen-Yu; Nichols, Thomas E; Ghosh, Debashis

2015-01-01

Recent research in neuroimaging has focused on assessing associations between genetic variants that are measured on a genomewide scale and brain imaging phenotypes. A large number of works in the area apply massively univariate analyses on a genomewide basis to find single nucleotide polymorphisms that influence brain structure. In this paper, we propose using various dimensionality reduction methods on both brain structural MRI scans and genomic data, motivated by the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. We also consider a new multiple testing adjustment method and compare it with two existing false discovery rate (FDR) adjustment methods. The simulation results suggest an increase in power for the proposed method. The real-data analysis suggests that the proposed procedure is able to find associations between genetic variants and brain volume differences that offer potentially new biological insights. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Histone Acetylome-wide Association Study of Autism Spectrum Disorder.

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Sun, Wenjie; Poschmann, Jeremie; Cruz-Herrera Del Rosario, Ricardo; Parikshak, Neelroop N; Hajan, Hajira Shreen; Kumar, Vibhor; Ramasamy, Ramalakshmi; Belgard, T Grant; Elanggovan, Bavani; Wong, Chloe Chung Yi; Mill, Jonathan; Geschwind, Daniel H; Prabhakar, Shyam

2016-11-17

The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brains. Despite etiological heterogeneity, ≥68% of syndromic and idiopathic ASD cases shared a common acetylome signature at >5,000 cis-regulatory elements in prefrontal and temporal cortex. Similarly, multiple genes associated with rare genetic mutations in ASD showed common "epimutations." Acetylome aberrations in ASD were not attributable to genetic differentiation at cis-SNPs and highlighted genes involved in synaptic transmission, ion transport, epilepsy, behavioral abnormality, chemokinesis, histone deacetylation, and immunity. By correlating histone acetylation with genotype, we discovered >2,000 histone acetylation quantitative trait loci (haQTLs) in human brain regions, including four candidate causal variants for psychiatric diseases. Due to the relative stability of histone modifications postmortem, we anticipate that the HAWAS approach will be applicable to multiple diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

Studying risk factors associated with Human Leptospirosis

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Ramachandra Kamath

2014-01-01

Full Text Available Background: Leptospirosis is one of the most under diagnosed and underreported disease in both developed and developing countries including India. It is established that environmental conditions and occupational habit of the individuals put them at risk of acquiring disease, which varies from community to community. Various seroprevalence studies across the world have documented emerging situation of this neglected tropical disease, but limited have probed to identify the risk factors, especially in India. Objectives: The objective of this study was to identify the environmental and occupational risk factors associated with the disease in Udupi District. Materials and Methods: This population-based case-control study was carried out in Udupi, a District in Southern India from April 2012 until August 2012. Udupi is considered to be endemic for Leptospirosis and reported 116 confirmed cases in the year 2011. Seventy of 116 laboratory confirmed cases and 140 sex matched neighborhood healthy controls participated in the study. A predesigned, semi-structured and validated questionnaire was used for data collection through house to house visit and observations were noted about environmental conditions. Univariate analysis followed by multivariate analysis (back ward conditional logistic regression was performed by using STATA version 9.2 (StataCorp, College Station, TX, USA to identify potential risk factors. Results: Occupational factors such as outdoor activities (matched odds ratio [OR] of 3.95, 95% confidence interval [CI]: 1.19-13.0, presence of cut or wound at body parts during work (matched OR: 4.88, CI: 1.83-13.02 and environmental factors such as contact with rodents through using the food materials ate by rat (matched OR: 4.29, CI: 1.45-12.73 and contact with soil or water contaminated with urine of rat (matched OR: 4.58, CI: 1.43-14.67 were the risk factors identified to be associated with disease. Conclusion: Leptospirosis is still

Mevlana’nın Menkıbeleri Üzerine Folklorik Bir İnceleme A Folkloric Analysis on the Legends of Mevlana

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Gülay KARAMAN

2012-09-01

Full Text Available behavior to be proud of. Its plural form menakıb for the first time in this meaning, is used in the corpus of hadith which had been written and compiled by IXth century to describe the virtues of prophet Muhammed and his companians. Furthermore, writings consist of the biography of historical personages, the description of works of worthies and even some of the holy cities are also called menakıb. While at the begining menakıbnames were created in order to describe high moral values of both the prophet Muhammed and his companians in later periods, the lives of some important men of sufism and religious orders were also added to this account. The first known example of Türkish menakıbname literature is Tezkire-i Satuk Buğra Han which is from Karahanlı period. Turkish menakıbname literature that begun with Tezkire-i Satuk Buğra Han, also continued to spread quickly among the Muslim Turks came to Anatolia and settled by migrations. Since the author is a member of his own society naturally his work will be a mirror to social, cultural, economical, political life of its century. For this reason, menakıbnames which tell the extraordinary life stories of saints are very important sources of information especially for history, culture, folklore and literature. After careful studies on the legends it can be possible to reach very rich source of information. In Türkiye, Fuad Köprülü is the first name with his work called as Türk Edebiyatında İlk Mutasavvıflar who pointed out using menakıbnames in scientific studies. In this study we want to call attention to Menâkıbu’l-Ârifîn which tells the legends of Mevlana and the other Mevlevi saints. Menâkıbu’l-Ârifîn is written by Mevlevi Ahmed Eflâkî in 14th century after the request of his sheik Ulu Arif Çelebi in Persian. This menakıbname has a certain place in Turkish history and culture since it gives first-hand information about Mevlana and the other Mevlevi saints. In this

Association of chronic periodontitis with metabolic syndrome: A cross-sectional study

Directory of Open Access Journals (Sweden)

Naresh Kumar

2016-01-01

Full Text Available Background: Prevalence of metabolic syndrome (MeS is high among Asians, including Indians and is rising, particularly with the adoption of modernized lifestyle. Various studies have reported a significant relationship between periodontal status and MeS. The objective of this study is to investigate the association between periodontitis and MeS. Materials and Methods: The study included 259 subjects (130 cases with chronic periodontitis, 129 controls without chronic periodontitis who underwent medical and periodontal checkup. Five components (obesity, high blood pressure, low- and high-density lipoproteins, cholesterol, hypertriglyceridemia, and high plasma glucose of MeS were evaluated, and individuals with ≥3 positive components were defined as having MeS. The periodontal parameter was clinical attachment level (CAL on the basis of which cases were selected with moderate (CAL loss 3–4 mm and severe (CAL loss ≥5 mm generalized chronic periodontitis. The association between chronic periodontitis and MeS components was investigated using odds ratios (ORs and 95% confidence intervals (CIs. Results: The association of MeS and chronic periodontitis was strong and significant with OR: 2.64, 95% CI: 1.36–5.18, and P< 0.003. Comparison of mean values of components of MeS between cases and controls reveals that the mean waist circumference (mean difference: −4.8 [95% CI: 7.75–−1.84], P< 0.002 and mean triglycerides level (mean difference: −25.75 [95% CI: −49.22–−2.28], P< 0.032 were significantly higher in cases than in control groups. Although mean systolic blood pressure, diastolic blood pressure, and fasting blood sugar level were higher in cases (125.77, 82.99 and 86.38, respectively compared with control (122.81, 81.3 and 83.68, respectively, it was statistically insignificant. Conclusion: The results of this study suggest that there is a strong association between chronic periodontitis and MeS. The association was independent

Burning mouth syndrome and associated factors: A case-control retrospective study.

Science.gov (United States)

Chimenos-Küstner, Eduardo; de Luca-Monasterios, Fiorella; Schemel-Suárez, Mayra; Rodríguez de Rivera-Campillo, María E; Pérez-Pérez, Alejandro M; López-López, José

2017-02-23

Burning mouth syndrome (BMS) can be defined as burning pain or dysesthesia on the tongue and/or other sites of the oral mucosa without a causative identifiable lesion. The discomfort is usually of daily recurrence, with a higher incidence among people aged 50 to 60 years, affecting mostly the female sex and diminishing their quality of life. The aim of this study was to evaluate the association between several pathogenic factors and burning mouth syndrome. 736 medical records of patients diagnosed of burning mouth syndrome and 132 medical records for the control group were studied retrospectively. The study time span was from January 1990 to December 2014. The protocol included: sex, age, type of oral discomfort and location, among other factors. Analysis of the association between pathogenic factors and BMS diagnosis revealed that only 3 factors showed a statistically significant association: triggers (P=.003), parafunctional habits (P=.006), and oral hygiene (P=.012). There were neither statistically significant differences in BMS incidence between sex groups (P=.408) nor association of BMS with the pathogenic factors of substance abuse (P=.915), systemic pathology (P=.685), and dietary habits (P=.904). Parafunctional habits like bruxism and abnormal movements of tongue and lips can explain the BMS main symptomatology. Psychological aspects and systemic factors should be always considered. As a multifactorial disorder, the treatment of BMS should be executed in a holistic way. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia

Science.gov (United States)

Mansour, Hader A; Talkowski, Michael E; Wood, Joel; Chowdari, Kodavali V; McClain, Lora; Prasad, Konasale; Montrose, Debra; Fagiolini, Andrea; Friedman, Edward S; Allen, Michael H; Bowden, Charles L; Calabrese, Joseph; El-Mallakh, Rif S; Escamilla, Michael; Faraone, Stephen V; Fossey, Mark D; Gyulai, Laszlo; Loftis, Jennifer M; Hauser, Peter; Ketter, Terence A; Marangell, Lauren B; Miklowitz, David J; Nierenberg, Andrew A; Patel, Jayendra; Sachs, Gary S; Sklar, Pamela; Smoller, Jordan W; Laird, Nan; Keshavan, Matcheri; Thase, Michael E; Axelson, David; Birmaher, Boris; Lewis, David; Monk, Tim; Frank, Ellen; Kupfer, David J; Devlin, Bernie; Nimgaonkar, Vishwajit L

2012-01-01

Objective Published studies suggest associations between circadian gene polymorphisms and bipolar I disorder (BPI), as well as schizoaffective disorder (SZA) and schizophrenia (SZ). The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders. Methods We assayed 276 publicly available ‘tag’ single nucleotide polymorphisms (SNPs) at 21 circadian genes among 523 patients with BPI, 527 patients with SZ/SZA, and 477 screened adult controls. Detected associations were evaluated in relation to two published genome-wide association studies (GWAS). Results Using gene-based tests, suggestive associations were noted between EGR3 and BPI (p = 0.017), and between NPAS2 and SZ/SZA (p = 0.034). Three SNPs were associated with both sets of disorders (NPAS2: rs13025524 and rs11123857; RORB: rs10491929; p < 0.05). None of the associations remained significant following corrections for multiple comparisons. Approximately 15% of the analyzed SNPs overlapped with an independent study that conducted GWAS for BPI; suggestive overlap between the GWAS analyses and ours was noted at ARNTL. Conclusions Several suggestive, novel associations were detected with circadian genes and BPI and SZ/SZA, but the present analyses do not support associations with common polymorphisms that confer risk with odds ratios greater than 1.5. Additional analyses using adequately powered samples are warranted to further evaluate these results. PMID:19839995

Tracheobronchomegaly associated tracheomalacia: analysis by sleep study.

Science.gov (United States)

Sundaram, P; Joshi, J M

2004-01-01

Tracheobronchomegaly (TBM) occasionally may progress to extensive tracheomalacia which leads to respiratory failure. Spirometry, dynamic expiratory multidetector computed tomography (CT), bronchoscopy are used to diagnose patients of suspected tracheobronchomalacia. We used the technique of night-time monitoring of respiratory variables to show the presence of respiratory abnormalities during sleep and which was corrected by applying nasal continuous positive airway pressure (CPAP). The study showed the presence of both apnoea and hypopnoeas, which were obstructive in nature with an apnoea-hypopnoea index (AHI) of 11, no snoring and associated oxygen desaturation of 75 per cent. A second overnight study with nasal continuous positive airway pressure at a critical pressure of 8 cm, the AHI decreased to 3 along with no drop in oxygen saturation. This non-invasive technique should be considered as a diagnostic tool in tracheobronchomalacia and to know the outcome of CPAP, surgical or stent therapy in this condition.

Case-control genome-wide association study of attention-deficit/hyperactivity disorder.

NARCIS (Netherlands)

Neale, B.M.; Medland, S.; Ripke, S.; Anney, R.J.; Asherson, P.; Buitelaar, J.K.; Franke, B.; Gill, M.; Kent, L.; Holmans, P.; Middleton, F.; Thapar, A.; Lesch, K.P.; Faraone, S.V.; Daly, M.; Nguyen, T.T.; Schafer, H.; Steinhausen, H.C.; Reif, A.; Renner, T.J.; Romanos, M.; Romanos, J.; Warnke, A.; Walitza, S.; Freitag, C.; Meyer, J.; Palmason, H.; Rothenberger, A.; Hawi, Z.; Sergeant, J.A.; Roeyers, H.; Mick, E.; Biederman, J.

2010-01-01

OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed.

An epidemiological study of environmental factors associated with canine obesity.

Science.gov (United States)

Courcier, E A; Thomson, R M; Mellor, D J; Yam, P S

2010-07-01

To assess the relationships between socioeconomic and other environmental factors with canine obesity. This was a cross-sectional questionnaire study of dog owners attending five primary veterinary practices in the UK. Owners were asked about dog age, neuter status, feeding habits, dog exercise, household income and owner age. The body condition score of the dogs was also assessed. Factors hypothesised to be associated with obesity were investigated. In total, data from 696 questionnaires were evaluated. Out of those data evaluated, 35.3% of dogs (n=246) were classed as an ideal body shape, 38.9% (n=271) were overweight, 20.4% (n=142) were obese and 5.3% (n=37) were underweight. Identified risk factors associated with obesity included owner age, hours of weekly exercise, frequency of snacks/treats and personal income. Environmental risk factors associated with canine obesity are multifactorial and include personal income, owner age, frequency of snacks/treats and amount of exercise the dog receives. Awareness about health risks associated with obesity in dogs is significantly less in people in lower income brackets. This phenomenon is recognised in human obesity.

The threat from without

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Lassi Saressalo

1987-01-01

Full Text Available Of greatest importance in ethnic folklore are the recognised and unrecognised elements that are used when founding identity on tradition. For the aim of ethnic identification is to note and know the cultural features that connect me with people like me and separate me from people who are not like me. Every group and each of its members thus needs an opponent, a contact partner in order to identify itself. What about the Lapps? The ethnocentric values of ethnic folklore provide a model for this generalising comparison. 'They' are a potential danger, are unknown, strange, a threat from beyond the fells. They are sufficiently common for the group's ethnic feeling. It is here that we find tradition, folk tales, describing the community's traditional enemies, describing the threat from without, engendering preconceived ideas, conflicts and even war. The Lapps have never had an empire, they have never conquered others' territory, they have never engaged in systematic warfare against other peoples. For this reason Lapp tradition lacks an offensive ethnic folklore proper with emphasis on aggression, power, violence, heroism and an acceptance of the ideology of subordinating others. On the contrary,Lapp folklore is familiar with a tradition in which strangers are always threatening the Lapps' existence, plundering their territories, burning and destroying. The Lapp has always had to fight against alien powers, to give in or to outwit the great and powerful enemy. In the Lapp tradition the staalo represents an outside threat that cannot be directly concretised. If foes are regarded as concrete enemies that may be defeated in physical combat or that can be made to look ridiculous, a staalo is more mythical, more supranormal, more vague. One basic feature of the staalo tradition is that it only appears as one party to a conflict. The stories about the Lapp who succeeds in driving away a staalo threatening the community, to outwit the stupid giant or to kill

Association between erectile dysfunction and chronic periodontitis: A clinical study

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Ranjit Singh Uppal

2014-01-01

Conclusion: It may be concluded that chronic periodontitis and ED are associated with each other. However, further large scale studies with confounder analysis and longitudinal follow-up are warranted to explore the link between these two diseases.

Genome-wide association study for female fertility in Nordic Red cattle

DEFF Research Database (Denmark)

Höglund, Johanna; Buitenhuis, Albert Johannes; Guldbrandtsen, Bernt

2015-01-01

cattle. The sub-traits of FTI are: number of inseminations per conception (AIS) in cows (C) and heifers (H), the length in days of the interval from calving to first insemination (ICF) in cows, days from first to last insemination (IFL) in cows and heifers, and 56-day non-return rate (NRR) in cows...... and heifers. The aim of this study was first to identify QTL for FTI by conducting a genome scan for variants associated with fertility index using imputed whole genome sequence data based on 4207 Nordic Red sires, and subsequently analyzing which of the sub-traits were affected by each FTI QTL by associating......). Conclusion This study 1) shows that many markers within FTI QTL regions were significantly associated with both AISH and IFLH, and 2) identified candidate genes for FTI located on BTA6 (GPR125), BTA13 (ANKRD60), BTA15 (GRAMD1B), and BTA24 (ZNF521). It is not known how the genes/variants identified...

Juegos y Diversiones. (Games Collected and Adapted to Teach Spanish to Children.)

Science.gov (United States)

Marquez, Nancy, Ed.; And Others

Games, both from the folklore heritage of children in Spanish-speaking countries and those created in the classroom, are excellent ways to teach language to children because they accomplish their language goals while entertaining and involving the children, often physically. Most games, because they are rigidly patterned and repetitious, are…

Drug discovery –How easy or how difficult?

Indian Academy of Sciences (India)

First page Back Continue Last page Graphics. Initial : Hit and Trial (Early approach 1900-1950s). Initial : Hit and Trial (Early approach 1900-1950s). Rational to some extent (Leads from natural products or folklore, analog synthesis and screening for a particular target). Rational based on knowledge of proteomics and ...

Phytochemical and antioxidant investigations of a Clausena anisata ...

African Journals Online (AJOL)

It has been established scientifically that oxidative stress is linked with several degenerative conditions and diseases; the inhibitory effects of these plant extracts on the free radicals could logically justify the folkloric usage of C. anisata leaf and bark in the Eastern Cape for the treatment of respiratory infection diseases.

Evaluation of Analgesic and Anti-inflammatory Activities of the Root ...

African Journals Online (AJOL)

Evaluation of Analgesic and Anti-inflammatory Activities of the Root Extracts of Indigofera spicata F. in Mice. ... The results clearly demonstrate the analgesic and anti-inflammatory effects of the aqueous and 80% methanolic root extracts of the plant, providing evidence in part for the folkloric use of the plant. Keywords: ...

A note on the Lie symmetries of complex partial differential

Indian Academy of Sciences (India)

Folklore suggests that the split Lie-like operators of a complex partial differential equation are symmetries of the split system of real partial differential equations. However, this is not the case generally. We illustrate this by using the complex heat equation, wave equation with dissipation, the nonlinear Burgers equation and ...