Hit or Run: Exploring Aggressive and Avoidant Reactions to Interpersonal Provocation Using a Novel Fight-or-Escape Paradigm (FOE).

Science.gov (United States)

Beyer, Frederike; Buades-Rotger, Macià; Claes, Marie; Krämer, Ulrike M

2017-01-01

Interpersonal provocation presents an approach-avoidance conflict to the provoked person: responding aggressively might yield the joy of retribution, whereas withdrawal can provide safety. Experimental aggression studies typically measure only retaliation intensity, neglecting whether individuals want to confront the provocateur at all. To overcome this shortcoming of previous measures, we developed and validated the Fight-or-Escape paradigm (FOE). The FOE is a competitive reaction time (RT) task in which the winner can choose the volume of a sound blast to be directed at his/her opponent. Participants face two ostensible opponents who consistently select either high or low punishments. At the beginning of each trial, subjects are given the chance to avoid the encounter for a limited number of times. In a first experiment ( n = 27, all women), we found that fear potentiation (FP) of the startle response was related to lower scores in a composite measure of aggression and avoidance against the provoking opponent. In a second experiment ( n = 34, 13 men), we altered the paradigm such that participants faced the opponents in alternating rather than in random order. Participants completed the FOE as well as the Dot-Probe Task (DPT) and the Approach-Avoidance Task (AAT). Subjects with higher approach bias scores in the AAT avoided the provoking opponent less frequently. Hence, individuals with high threat reactivity and low approach motivation displayed more avoidant responses to provocation, whereas participants high in approach motivation were more likely to engage in aggressive interactions when provoked. The FOE is thus a promising laboratory measure of avoidance and aggression.

Sulfur dioxide: foe or friend for life?

Science.gov (United States)

Wang, Xin-Bao; Cui, Hong; Liu, Xiaohong; Du, Jun-Bao

2017-12-01

Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-containing amino acid, L-cysteine. Recent studies have shown that SO₂ has a vasorelaxant effect, and ameliorates pulmonary hypertension and vascular remodeling. SO₂ can also reduce lung injury and myocardial injury in rats. In addition, SO₂ reduces myocardial ischemia-reperfusion injury and atherosclerotic lesions. Therefore, SO₂ exerts both detrimental and protective effects in mammals. Is SO₂ a foe or friend for life?.

Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

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Shyu, Yu-Chiau; Lee, Tung-Liang; Chen, Xin; Hsu, Pang-Hung; Wen, Shau-Ching; Liaw, Yi-Wei; Lu, Chi-Huan; Hsu, Po-Yen; Lu, Mu-Jie; Hwang, JauLang; Tsai, Ming-Daw; Hwang, Ming-Jing; Chen, Jim-Ray; Shen, Che-Kun James

2014-02-24

Erythropoiesis is a highly regulated process during which BFU-E are differentiated into RBCs through CFU-E, Pro-E, PolyCh-E, OrthoCh-E, and reticulocyte stages. Uniquely, most erythroid-specific genes are activated during the Pro-E to Baso-E transition. We show that a wave of nuclear import of the erythroid-specific transcription factor EKLF occurs during the Pro-E to Baso-E transition. We further demonstrate that this wave results from a series of finely tuned events, including timed activation of PKCθ, phosphorylation of EKLF at S68 by P-PKCθ(S676), and sumoylation of EKLF at K74. The latter EKLF modifications modulate its interactions with a cytoplasmic ankyrin-repeat-protein FOE and importinβ1, respectively. The role of FOE in the control of EKLF nuclear import is further supported by analysis of the subcellular distribution patterns of EKLF in FOE-knockout mice. This study reveals the regulatory mechanisms of the nuclear import of EKLF, which may also be utilized in the nuclear import of other factors. Copyright © 2014 Elsevier Inc. All rights reserved.

Evidence of chemical stimulation of hepatic metabolism by an experimental acetanilide (FOE 5043) indirectly mediating reductions in circulating thyroid hormone levels in the male rat.

Science.gov (United States)

Christenson, W R; Becker, B D; Wahle, B S; Moore, K D; Dass, P D; Lake, S G; Van Goethem, D L; Stuart, B P; Sangha, G K; Thyssen, J H

1996-02-01

N-(4-Fluorophenyl)-N-(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3, 4-thiadiazol-2-yl]oxy]acetamide (FOE 5043) is a new acetanilide-type herbicide undergoing regulatory testing. Previous work in this laboratory suggested that FOE 5043-induced reductions in serum thyroxine (T4) levels were mediated via an extrathyroidal site of action. The possibility that the alterations in circulating T4 levels were due to chemical induction of hepatic thyroid hormone metabolism was investigated. Treatment with FOE 5043 at a rate of 1000 ppm as a dietary admixture was found to significantly increase the clearance of [125I]T4 from the serum, suggesting an enhanced excretion of the hormone. In the liver, the activity of hepatic uridine glucuronosyl transferase, a major pathway of thyroid hormone biotransformation in the rat, increased in a statistically significant and dose-dependent manner; conversely, hepatic 5'-monodeiodinase activity trended downward with dose. Bile flow as well as the hepatic uptake and biliary excretion of [125I]T4 were increased following exposure to FOE 5043. Thyroidal function, as measured by the discharge of iodide ion in response to perchlorate, and pituitary function, as measured by the capacity of the pituitary to secrete thyrotropin in response to an exogenous challenge by hypothalamic thyrotropin releasing hormone, were both unchanged from the controlled response. These data suggest that the functional status of the thyroid and pituitary glands has not been altered by treatment with FOE 5043 and that reductions in circulating levels of T4 are being mediated indirectly through an increase in the biotransformation and excretion of thyroid hormone in the liver.

Scalability of Parallel Scientific Applications on the Cloud

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Satish Narayana Srirama

2011-01-01

Full Text Available Cloud computing, with its promise of virtually infinite resources, seems to suit well in solving resource greedy scientific computing problems. To study the effects of moving parallel scientific applications onto the cloud, we deployed several benchmark applications like matrix–vector operations and NAS parallel benchmarks, and DOUG (Domain decomposition On Unstructured Grids on the cloud. DOUG is an open source software package for parallel iterative solution of very large sparse systems of linear equations. The detailed analysis of DOUG on the cloud showed that parallel applications benefit a lot and scale reasonable on the cloud. We could also observe the limitations of the cloud and its comparison with cluster in terms of performance. However, for efficiently running the scientific applications on the cloud infrastructure, the applications must be reduced to frameworks that can successfully exploit the cloud resources, like the MapReduce framework. Several iterative and embarrassingly parallel algorithms are reduced to the MapReduce model and their performance is measured and analyzed. The analysis showed that Hadoop MapReduce has significant problems with iterative methods, while it suits well for embarrassingly parallel algorithms. Scientific computing often uses iterative methods to solve large problems. Thus, for scientific computing on the cloud, this paper raises the necessity for better frameworks or optimizations for MapReduce.

Cancer-associated lysosomal changes: friends or foes?

Science.gov (United States)

Kallunki, T; Olsen, O D; Jäättelä, M

2013-04-18

Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic changes in lysosomal volume, composition and cellular distribution. Depending on one's point of view, the cancer-associated changes in the lysosomal compartment can be regarded as friends or foes. Most of them are clearly transforming as they promote invasive growth, angiogenesis and drug resistance. The same changes can, however, strongly sensitize cells to lysosomal membrane permeabilization and thereby to lysosome-targeting anti-cancer drugs. In this review we compile our current knowledge on cancer-associated changes in lysosomal composition and discuss the consequences of these alterations to cancer progression and the possibilities they can bring to cancer therapy.

Scientific applications of symbolic computation

International Nuclear Information System (INIS)

Hearn, A.C.

1976-02-01

The use of symbolic computation systems for problem solving in scientific research is reviewed. The nature of the field is described, and particular examples are considered from celestial mechanics, quantum electrodynamics and general relativity. Symbolic integration and some more recent applications of algebra systems are also discussed [fr

Autophagy in endometriosis: Friend or foe?

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Zhan, Lei; Li, Jun; Wei, Bing

2018-01-01

Endometriosis is a chronic, estrogen-dependent disease and characterized by the implantation of endometrial glands and stroma deep and haphazardly into the outside the uterine cavity. It affects an estimated 10% of the female population of reproductive age and results in obvious reduction in health-related quality of life. Unfortunately, there is no a consistent theory for the etiology of endometriosis. Furthermore, the endometriosis is hard to diagnose in early stage and the treatment methods are limited. Importantly, emerging evidence has investigated that there is a close relationship between endometriosis and autophagy. However, autophagy is a friend or foe in endometriosis is puzzling, the precise mechanism underlying autophagy in endometriosis has not been fully elucidated yet. Here, we provide an integrated view on the acquired findings of the connections between endometriosis and autophagy. We also discuss which may contribute to the abnormal level of autophagy in endometriosis. Copyright © 2017 Elsevier Inc. All rights reserved.

"Friends" and "Foes" in the Social Space of the Tatar Ethnic Group

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Nataliia O. Khazieva

2017-10-01

Full Text Available The history of the World Culture is a demonstration of the "war" between the two opposites: on the one hand, we see a trend towards unification of all aspects of life on a global scale, and on the other, there is a clear confrontation between different groups of mankind. Of the many causes of the disunity of the people, the authors' focus at the opposition "friend – foe" as a metaphysical principle of formation of social space wasn't chosen by accident. The fact is that any culture, in principle, is dichotomous, and the opposition "friend – foe" is the fullest incarnation of this dichotomy. As a universal principle of the formation and functioning of the cultures, it originally manifests itself in every one of them. And, as the authors of the study suggest: this opposition could either "work" in general on the cross-cultural cooperation and unity or be one of the confrontation sources. The main result of the study is that history has prepared and put forward the Tartars for carrying out a special mission, to unite peoples and cultures. But the revolutionary social upheavals that take place in the modern world pose a threat (in the circumstances of forced migration of peoples, the growth of national consciousness of the former Soviet Union space, and especially in the face of Islamic fundamentalism on fulfilling this function.

Mistletoe, friend and foe: synthesizing ecosystem implications of mistletoe infection

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Griebel, Anne; Watson, David; Pendall, Elise

2017-11-01

Biotic disturbances are affecting a wide range of tree species in all climates, and their occurrence is contributing to increasing rates of tree mortality globally. Mistletoe is a widespread group of parasitic plants that establishes long-lasting relationships with a diverse range of host tree species. With climate change, ecophysiological stress is increasing, potentially making trees more susceptible to mistletoe infection, which in turn leads to higher forest mortality rates. The perception of mistletoe presence in individual trees and forest stands is divided within the scientific community, leading to an ongoing debate regarding its impacts. Forest managers concerned about stand health and carbon sequestration may view mistletoe as a foe that leads to reduced productivity. In contrast, ecologists may see mistletoe as a friend, in light of the wildlife habitat, biodiversity and nutrient cycling it promotes. However, individual studies typically focus on isolated effects of mistletoe presence within their respective research area and lack a balanced, interdisciplinary perspective of mistletoe disturbance. With this conceptual paper we aim to bring together the positive and negative impacts of mistletoe presence on tree physiology, soil nutrient cycling as well as stand health and stand dynamics. We focus on the role of mistletoe-induced tree mortality in ecosystem succession and biodiversity. In addition, we present potential modifications of mistletoe presence on the energy budget and on forest vulnerability to climate change, which could feed back into stand dynamics and disturbance patterns. Lastly, we will identify the most pressing remaining knowledge gaps and highlight priorities for future research on this widespread agent of biotic disturbance.

Robinson Crusoé em Foe: Coetzee Lê Defoe com as lentes do pós-colonialismo

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Wellington Ricardo Fioruci

2015-06-01

Full Text Available Este estudo consiste na análise de dois importantes romances representativos do gênero narrativa de viagem, a saber, Robinson Crusoé (1719 e Foe (1986, cujos autores, respectivamente Daniel Defoe, no século XVIII, e John Maxwell Coetzee, no século XX, dialogam também ao escreverem na língua de Shakespeare. Partindo desses cruzamentos, busca-se estabelecer, através do comparativismo literário, as relações históricas e textuais entre suas respectivas obras. O romance Foe aparece como uma releitura contemporânea do gênero relatos de viagem, o qual já havia sido desenvolvido em Robinson Crusoé, romance precursor desta categoria temática. Coetzee retoma o clássico tecendo reflexões a respeito do contexto colonialista em que Defoe escrevia. Desse modo, Coetzee lança um novo olhar para o tema sob o enfoque do pós-colonialismo. Tal perspectiva reflete no modo de escritura do texto, de forma que o gênero, reflexo da imagem de uma época, acaba sendo reconstruído, de acordo com a perspectiva pós-moderna.

Scientific production and technological production: transforming a scientific paper into patent applications.

Science.gov (United States)

Dias, Cleber Gustavo; Almeida, Roberto Barbosa de

2013-01-01

Brazil has been presenting in the last years a scientific production well-recognized in the international scenario, in several areas of knowledge, according to the impact of their publications in important events and especially in indexed journals of wide circulation. On the other hand, the country does not seem to be in the same direction regarding to the technological production and wealth creation from the established scientific development, and particularly from the applied research. The present paper covers such issue and discloses the main similarities and differences between a scientific paper and a patent application, in order to contribute to a better understanding of both types of documents and help the researchers to chose and select the results with technological potential, decide what is appropriated for industrial protection, as well as foster new business opportunities for each technology which has been created.

Lactobacillus iners: Friend or Foe?

Science.gov (United States)

Petrova, Mariya I; Reid, Gregor; Vaneechoutte, Mario; Lebeer, Sarah

2017-03-01

The vaginal microbial community is typically characterized by abundant lactobacilli. Lactobacillus iners, a fairly recently detected species, is frequently present in the vaginal niche. However, the role of this species in vaginal health is unclear, since it can be detected in normal conditions as well as during vaginal dysbiosis, such as bacterial vaginosis, a condition characterized by an abnormal increase in bacterial diversity and lack of typical lactobacilli. Compared to other Lactobacillus species, L. iners has more complex nutritional requirements and a Gram-variable morphology. L. iners has an unusually small genome (ca. 1 Mbp), indicative of a symbiotic or parasitic lifestyle, in contrast to other lactobacilli that show niche flexibility and genomes of up to 3-4 Mbp. The presence of specific L. iners genes, such as those encoding iron-sulfur proteins and unique σ-factors, reflects a high degree of niche specification. The genome of L. iners strains also encodes inerolysin, a pore-forming toxin related to vaginolysin of Gardnerella vaginalis. Possibly, this organism may have clonal variants that in some cases promote a healthy vagina, and in other cases are associated with dysbiosis and disease. Future research should examine this friend or foe relationship with the host. Copyright © 2016 Elsevier Ltd. All rights reserved.

Advanced scientific computational methods and their applications to nuclear technologies. (4) Overview of scientific computational methods, introduction of continuum simulation methods and their applications (4)

International Nuclear Information System (INIS)

Sekimura, Naoto; Okita, Taira

2006-01-01

Scientific computational methods have advanced remarkably with the progress of nuclear development. They have played the role of weft connecting each realm of nuclear engineering and then an introductory course of advanced scientific computational methods and their applications to nuclear technologies were prepared in serial form. This is the fourth issue showing the overview of scientific computational methods with the introduction of continuum simulation methods and their applications. Simulation methods on physical radiation effects on materials are reviewed based on the process such as binary collision approximation, molecular dynamics, kinematic Monte Carlo method, reaction rate method and dislocation dynamics. (T. Tanaka)

Are Cloud Environments Ready for Scientific Applications?

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Mehrotra, P.; Shackleford, K.

2011-12-01

Cloud computing environments are becoming widely available both in the commercial and government sectors. They provide flexibility to rapidly provision resources in order to meet dynamic and changing computational needs without the customers incurring capital expenses and/or requiring technical expertise. Clouds also provide reliable access to resources even though the end-user may not have in-house expertise for acquiring or operating such resources. Consolidation and pooling in a cloud environment allow organizations to achieve economies of scale in provisioning or procuring computing resources and services. Because of these and other benefits, many businesses and organizations are migrating their business applications (e.g., websites, social media, and business processes) to cloud environments-evidenced by the commercial success of offerings such as the Amazon EC2. In this paper, we focus on the feasibility of utilizing cloud environments for scientific workloads and workflows particularly of interest to NASA scientists and engineers. There is a wide spectrum of such technical computations. These applications range from small workstation-level computations to mid-range computing requiring small clusters to high-performance simulations requiring supercomputing systems with high bandwidth/low latency interconnects. Data-centric applications manage and manipulate large data sets such as satellite observational data and/or data previously produced by high-fidelity modeling and simulation computations. Most of the applications are run in batch mode with static resource requirements. However, there do exist situations that have dynamic demands, particularly ones with public-facing interfaces providing information to the general public, collaborators and partners, as well as to internal NASA users. In the last few months we have been studying the suitability of cloud environments for NASA's technical and scientific workloads. We have ported several applications to

Advanced scientific computational methods and their applications of nuclear technologies. (1) Overview of scientific computational methods, introduction of continuum simulation methods and their applications (1)

International Nuclear Information System (INIS)

Oka, Yoshiaki; Okuda, Hiroshi

2006-01-01

Scientific computational methods have advanced remarkably with the progress of nuclear development. They have played the role of weft connecting each realm of nuclear engineering and then an introductory course of advanced scientific computational methods and their applications to nuclear technologies were prepared in serial form. This is the first issue showing their overview and introduction of continuum simulation methods. Finite element method as their applications is also reviewed. (T. Tanaka)

RAPPORT: running scientific high-performance computing applications on the cloud.

Science.gov (United States)

Cohen, Jeremy; Filippis, Ioannis; Woodbridge, Mark; Bauer, Daniela; Hong, Neil Chue; Jackson, Mike; Butcher, Sarah; Colling, David; Darlington, John; Fuchs, Brian; Harvey, Matt

2013-01-28

Cloud computing infrastructure is now widely used in many domains, but one area where there has been more limited adoption is research computing, in particular for running scientific high-performance computing (HPC) software. The Robust Application Porting for HPC in the Cloud (RAPPORT) project took advantage of existing links between computing researchers and application scientists in the fields of bioinformatics, high-energy physics (HEP) and digital humanities, to investigate running a set of scientific HPC applications from these domains on cloud infrastructure. In this paper, we focus on the bioinformatics and HEP domains, describing the applications and target cloud platforms. We conclude that, while there are many factors that need consideration, there is no fundamental impediment to the use of cloud infrastructure for running many types of HPC applications and, in some cases, there is potential for researchers to benefit significantly from the flexibility offered by cloud platforms.

Application of Logic Models in a Large Scientific Research Program

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O'Keefe, Christine M.; Head, Richard J.

2011-01-01

It is the purpose of this article to discuss the development and application of a logic model in the context of a large scientific research program within the Commonwealth Scientific and Industrial Research Organisation (CSIRO). CSIRO is Australia's national science agency and is a publicly funded part of Australia's innovation system. It conducts…

Applications of artificial intelligence to scientific research

Science.gov (United States)

Prince, Mary Ellen

1986-01-01

Artificial intelligence (AI) is a growing field which is just beginning to make an impact on disciplines other than computer science. While a number of military and commercial applications were undertaken in recent years, few attempts were made to apply AI techniques to basic scientific research. There is no inherent reason for the discrepancy. The characteristics of the problem, rather than its domain, determines whether or not it is suitable for an AI approach. Expert system, intelligent tutoring systems, and learning programs are examples of theoretical topics which can be applied to certain areas of scientific research. Further research and experimentation should eventurally make it possible for computers to act as intelligent assistants to scientists.

STAT1 in cancer: friend or foe?

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Zhang, Ying; Liu, Zhaoyong

2017-08-01

The first STAT family member, STAT1, is an essential component of interferon (IFN)-signaling, which mediates several cellular functions in response to stimulation by cytokines, growth factors, and hormones, such as the IFNs and IL-6. The role and significance of STAT1 in cancer biology have been studied for a decade. The majority of evidence shows that activating STAT1 plays a tumor suppressor role in cancer cells. Nevertheless, results from some experiments and clinical studies suggest that STAT1 also exerts tumor promoter effects under specific conditions. In some malignant phenotypes, STAT1 can function either as an oncoprotein or tumor suppressor in the same cell type, depending on the specific genetic background. Thus, the function of STAT1 in cancer biology remains a mystery. In this review, we discuss both the "friend" and "foe" features of STAT1 by summarizing its tumor suppressor or oncogenic functions and mechanisms. To explain how STAT1 may mediate its tumor suppressor effects, we discuss several possible mechanisms, one of which is linked to the role of STAT1β, an isoform of STAT1.

Load Balancing Scientific Applications

Energy Technology Data Exchange (ETDEWEB)

Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)

2014-12-01

The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.

Implementation of Scientific Computing Applications on the Cell Broadband Engine

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Guochun Shi

2009-01-01

Full Text Available The Cell Broadband Engine architecture is a revolutionary processor architecture well suited for many scientific codes. This paper reports on an effort to implement several traditional high-performance scientific computing applications on the Cell Broadband Engine processor, including molecular dynamics, quantum chromodynamics and quantum chemistry codes. The paper discusses data and code restructuring strategies necessary to adapt the applications to the intrinsic properties of the Cell processor and demonstrates performance improvements achieved on the Cell architecture. It concludes with the lessons learned and provides practical recommendations on optimization techniques that are believed to be most appropriate.

Vision systems for scientific and engineering applications

International Nuclear Information System (INIS)

Chadda, V.K.

2009-01-01

Human performance can get degraded due to boredom, distraction and fatigue in vision-related tasks such as measurement, counting etc. Vision based techniques are increasingly being employed in many scientific and engineering applications. Notable advances in this field are emerging from continuing improvements in the fields of sensors and related technologies, and advances in computer hardware and software. Automation utilizing vision-based systems can perform repetitive tasks faster and more accurately, with greater consistency over time than humans. Electronics and Instrumentation Services Division has developed vision-based systems for several applications to perform tasks such as precision alignment, biometric access control, measurement, counting etc. This paper describes in brief four such applications. (author)

Application of Text Analytics to Extract and Analyze Material–Application Pairs from a Large Scientific Corpus

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Nikhil Kalathil

2018-01-01

Full Text Available When assessing the importance of materials (or other components to a given set of applications, machine analysis of a very large corpus of scientific abstracts can provide an analyst a base of insights to develop further. The use of text analytics reduces the time required to conduct an evaluation, while allowing analysts to experiment with a multitude of different hypotheses. Because the scope and quantity of metadata analyzed can, and should, be large, any divergence from what a human analyst determines and what the text analysis shows provides a prompt for the human analyst to reassess any preliminary findings. In this work, we have successfully extracted material–application pairs and ranked them on their importance. This method provides a novel way to map scientific advances in a particular material to the application for which it is used. Approximately 438,000 titles and abstracts of scientific papers published from 1992 to 2011 were used to examine 16 materials. This analysis used coclustering text analysis to associate individual materials with specific clean energy applications, evaluate the importance of materials to specific applications, and assess their importance to clean energy overall. Our analysis reproduced the judgments of experts in assigning material importance to applications. The validated methods were then used to map the replacement of one material with another material in a specific application (batteries.

Friends and foes from an ant brain's point of view--neuronal correlates of colony odors in a social insect.

Science.gov (United States)

Brandstaetter, Andreas Simon; Rössler, Wolfgang; Kleineidam, Christoph Johannes

2011-01-01

Successful cooperation depends on reliable identification of friends and foes. Social insects discriminate colony members (nestmates/friends) from foreign workers (non-nestmates/foes) by colony-specific, multi-component colony odors. Traditionally, complex processing in the brain has been regarded as crucial for colony recognition. Odor information is represented as spatial patterns of activity and processed in the primary olfactory neuropile, the antennal lobe (AL) of insects, which is analogous to the vertebrate olfactory bulb. Correlative evidence indicates that the spatial activity patterns reflect odor-quality, i.e., how an odor is perceived. For colony odors, alternatively, a sensory filter in the peripheral nervous system was suggested, causing specific anosmia to nestmate colony odors. Here, we investigate neuronal correlates of colony odors in the brain of a social insect to directly test whether they are anosmic to nestmate colony odors and whether spatial activity patterns in the AL can predict how odor qualities like "friend" and "foe" are attributed to colony odors. Using ant dummies that mimic natural conditions, we presented colony odors and investigated their neuronal representation in the ant Camponotus floridanus. Nestmate and non-nestmate colony odors elicited neuronal activity: In the periphery, we recorded sensory responses of olfactory receptor neurons (electroantennography), and in the brain, we measured colony odor specific spatial activity patterns in the AL (calcium imaging). Surprisingly, upon repeated stimulation with the same colony odor, spatial activity patterns were variable, and as variable as activity patterns elicited by different colony odors. Ants are not anosmic to nestmate colony odors. However, spatial activity patterns in the AL alone do not provide sufficient information for colony odor discrimination and this finding challenges the current notion of how odor quality is coded. Our result illustrates the enormous challenge

An ontology model for execution records of Grid scientific applications

NARCIS (Netherlands)

Baliś, B.; Bubak, M.

2008-01-01

Records of past application executions are particularly important in the case of loosely-coupled, workflow driven scientific applications which are used to conduct in silico experiments, often on top of Grid infrastructures. In this paper, we propose an ontology-based model for storing and querying

78 FR 52760 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2013-08-26

... invite comments on the question of whether instruments of equivalent scientific value, for the purposes... platforms based on self- assembled DNA nanostructures for studying cell biology. DNA nanostructures will be... 23, 2013. Docket Number: 13-033. Applicant: University of Pittsburgh School of Medicine, 3500 Terrace...

The Schistosoma Granuloma: Friend or Foe?

Science.gov (United States)

Hams, Emily; Aviello, Gabriella; Fallon, Padraic G.

2013-01-01

Infection of man with Schistosoma species of trematode parasite causes marked chronic morbidity. Individuals that become infected with Schistosomes may develop a spectrum of pathology ranging from mild cercarial dermatitis to severe tissue inflammation, in particular within the liver and intestines, which can lead to life threatening hepatosplenomegaly. It is well established that the etiopathology during schistosomiasis is primarily due to an excessive or unregulated inflammatory response to the parasite, in particular to eggs that become trapped in various tissue. The eggs forms the foci of a classical type 2 granulomatous inflammation, characterized by an eosinophil-rich, CD4+ T helper (Th) 2 cell dominated infiltrate with additional infiltration of alternatively activated macrophages (M2). Indeed the sequela of the type 2 perioval granuloma is marked fibroblast infiltration and development of fibrosis. Paradoxically, while the granuloma is the cause of pathology it also can afford some protection, whereby the granuloma minimizes collateral tissue damage in the liver and intestines. Furthermore, the parasite is exquisitely reliant on the host to mount a granulomatous reaction to the eggs as this inflammatory response facilitates the successful excretion of the eggs from the host. In this focused review we will address the conundrum of the S. mansoni granuloma acting as both friend and foe in inflammation during infection. PMID:23596444

Applications of field-programmable gate arrays in scientific research

CERN Document Server

Sadrozinski, Hartmut F W

2011-01-01

Focusing on resource awareness in field-programmable gate array (FPGA) design, Applications of Field-Programmable Gate Arrays in Scientific Research covers the principle of FPGAs and their functionality. It explores a host of applications, ranging from small one-chip laboratory systems to large-scale applications in ""big science."" The book first describes various FPGA resources, including logic elements, RAM, multipliers, microprocessors, and content-addressable memory. It then presents principles and methods for controlling resources, such as process sequencing, location constraints, and in

Manuscript Architect: a Web application for scientific writing in virtual interdisciplinary groups

Directory of Open Access Journals (Sweden)

Menezes Andreia P

2005-06-01

Full Text Available Abstract Background Although scientific writing plays a central role in the communication of clinical research findings and consumes a significant amount of time from clinical researchers, few Web applications have been designed to systematically improve the writing process. This application had as its main objective the separation of the multiple tasks associated with scientific writing into smaller components. It was also aimed at providing a mechanism where sections of the manuscript (text blocks could be assigned to different specialists. Manuscript Architect was built using Java language in conjunction with the classic lifecycle development method. The interface was designed for simplicity and economy of movements. Manuscripts are divided into multiple text blocks that can be assigned to different co-authors by the first author. Each text block contains notes to guide co-authors regarding the central focus of each text block, previous examples, and an additional field for translation when the initial text is written in a language different from the one used by the target journal. Usability was evaluated using formal usability tests and field observations. Results The application presented excellent usability and integration with the regular writing habits of experienced researchers. Workshops were developed to train novice researchers, presenting an accelerated learning curve. The application has been used in over 20 different scientific articles and grant proposals. Conclusion The current version of Manuscript Architect has proven to be very useful in the writing of multiple scientific texts, suggesting that virtual writing by interdisciplinary groups is an effective manner of scientific writing when interdisciplinary work is required.

Fever and sickness behavior: Friend or foe?

Science.gov (United States)

Harden, L M; Kent, S; Pittman, Q J; Roth, J

2015-11-01

Fever has been recognized as an important symptom of disease since ancient times. For many years, fever was treated as a putative life-threatening phenomenon. More recently, it has been recognized as an important part of the body's defense mechanisms; indeed at times it has even been used as a therapeutic agent. The knowledge of the functional role of the central nervous system in the genesis of fever has greatly improved over the last decade. It is clear that the febrile process, which develops in the sick individual, is just one of many brain-controlled sickness symptoms. Not only will the sick individual appear "feverish" but they may also display a range of behavioral changes, such as anorexia, fatigue, loss of interest in usual daily activities, social withdrawal, listlessness or malaise, hyperalgesia, sleep disturbances and cognitive dysfunction, collectively termed "sickness behavior". In this review we consider the issue of whether fever and sickness behaviors are friend or foe during: a critical illness, the common cold or influenza, in pregnancy and in the newborn. Deciding whether these sickness responses are beneficial or harmful will very much shape our approach to the use of antipyretics during illness. Copyright © 2015 Elsevier Inc. All rights reserved.

Strategies for application of scientific findings in prevention.

Science.gov (United States)

Wei, S H

1995-07-01

Dental research in the last 50 years has accomplished numerous significant advances in preventive dentistry, particularly in the area of research in fluorides, periodontal diseases, restorative dentistry, and dental materials, as well as craniofacial development and molecular biology. The transfer of scientific knowledge to clinical practitioners requires additional effort. It is the responsibility of the scientific communities to transfer the fruits of their findings to society through publications, conferences, media, and the press. Specific programs that the International Association for Dental Research (IADR) has developed to transmit science to the profession and the public have included science transfer seminars, the Visiting Lecture Program, and hands-on workshops. The IADR Strategic Plan also has a major outreach goal. In addition, the Federation Dentaire Internationale (FDI) and the World Health Organization (WHO) have initiated plans to celebrate World Health Day and the Year of Oral Health in 1994. These are important strategies for the application of scientific findings in prevention.

Friend-foe paradigm: A model of antiserbian propaganda in the nineties

Directory of Open Access Journals (Sweden)

Vuković Slobodan

2008-01-01

Full Text Available In this article foundations of antiserbian propaganda in euro-american media in the nineties are widely discussed. In the main pattern it was copy of old Austro-Hungarian and Comminterian antiserbian propaganda procedures. In keeping with this procedures Slovenian and Croats, and lately Albanians, are connected with positive values identified with Good, and Serbs with negative ones, identified with Evil. Thus, justification for disintegration of Yugoslavia were provided with main move to accuse Serbs and Serbia for it. Key of such a propaganda could be find in Carl Schmitt's friend-foe dualism which contains moral oppositions good-evil, esthetic beauty-ugly, and economic useful-harmful. Therefore, Serbs in euro-american, especially in german press and other media were represented as evil and ugly ones, thus providing justification for humiliating them on the moral plane. .

A framework for distributed mixed-language scientific applications

International Nuclear Information System (INIS)

Quarrie, D.R.

1996-01-01

The Object Management Group has defined an architecture (COBRA) for distributed object applications based on an Object Broker and Interface Definition Language. This project builds upon this architecture to establish a framework for the creation of mixed language scientific applications. A prototype compiler has been written that generates FORTRAN 90 or Eiffel subs and skeletons and the required C++ glue code from an input IDL file that specifies object interfaces. This generated code can be used directly for non-distributed mixed language applications or in conjunction with the C++ code generated from a commercial IDL compiler for distributed applications. A feasibility study is presently to see whether a fully integrated software development environment for distributed, mixed-language applications can be created by modifying the back-end code generator of a commercial CASE tool to emit IDL. (author)

A framework for integration of scientific applications into the OpenTopography workflow

Science.gov (United States)

Nandigam, V.; Crosby, C.; Baru, C.

2012-12-01

The NSF-funded OpenTopography facility provides online access to Earth science-oriented high-resolution LIDAR topography data, online processing tools, and derivative products. The underlying cyberinfrastructure employs a multi-tier service oriented architecture that is comprised of an infrastructure tier, a processing services tier, and an application tier. The infrastructure tier consists of storage, compute resources as well as supporting databases. The services tier consists of the set of processing routines each deployed as a Web service. The applications tier provides client interfaces to the system. (e.g. Portal). We propose a "pluggable" infrastructure design that will allow new scientific algorithms and processing routines developed and maintained by the community to be integrated into the OpenTopography system so that the wider earth science community can benefit from its availability. All core components in OpenTopography are available as Web services using a customized open-source Opal toolkit. The Opal toolkit provides mechanisms to manage and track job submissions, with the help of a back-end database. It allows monitoring of job and system status by providing charting tools. All core components in OpenTopography have been developed, maintained and wrapped as Web services using Opal by OpenTopography developers. However, as the scientific community develops new processing and analysis approaches this integration approach is not scalable efficiently. Most of the new scientific applications will have their own active development teams performing regular updates, maintenance and other improvements. It would be optimal to have the application co-located where its developers can continue to actively work on it while still making it accessible within the OpenTopography workflow for processing capabilities. We will utilize a software framework for remote integration of these scientific applications into the OpenTopography system. This will be accomplished by

Impulse: Memory System Support for Scientific Applications

Directory of Open Access Journals (Sweden)

John B. Carter

1999-01-01

Full Text Available Impulse is a new memory system architecture that adds two important features to a traditional memory controller. First, Impulse supports application‐specific optimizations through configurable physical address remapping. By remapping physical addresses, applications control how their data is accessed and cached, improving their cache and bus utilization. Second, Impulse supports prefetching at the memory controller, which can hide much of the latency of DRAM accesses. Because it requires no modification to processor, cache, or bus designs, Impulse can be adopted in conventional systems. In this paper we describe the design of the Impulse architecture, and show how an Impulse memory system can improve the performance of memory‐bound scientific applications. For instance, Impulse decreases the running time of the NAS conjugate gradient benchmark by 67%. We expect that Impulse will also benefit regularly strided, memory‐bound applications of commercial importance, such as database and multimedia programs.

Techniques and tools for measuring energy efficiency of scientific software applications

CERN Document Server

Abdurachmanov, David; Eulisse, Giulio; Knight, Robert; Niemi, Tapio; Nurminen, Jukka K.; Nyback, Filip; Pestana, Goncalo; Ou, Zhonghong; Khan, Kashif

2014-01-01

The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power ARM processors, to replace traditional Intel x86 architectures. Nevertheless, even though such solutions have been successfully used in mobile applications with low I/O and memory demands, it is unclear if they are suitable and more energy-efficient in the scientific computing environment. Furthermore, there is a lack of tools and experience to derive and compare power consumption between the architectures for various workloads, and eventually to support software optimizations for energy efficiency. To that end, we have performed several physical and software-based measurements of workloads from HEP applications running o...

Techniques and tools for measuring energy efficiency of scientific software applications

International Nuclear Information System (INIS)

Abdurachmanov, David; Elmer, Peter; Eulisse, Giulio; Knight, Robert; Niemi, Tapio; Pestana, Gonçalo; Khan, Kashif; Nurminen, Jukka K; Nyback, Filip; Ou, Zhonghong

2015-01-01

The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power ARM processors, to replace traditional Intel x86 architectures. Nevertheless, even though such solutions have been successfully used in mobile applications with low I/O and memory demands, it is unclear if they are suitable and more energy-efficient in the scientific computing environment. Furthermore, there is a lack of tools and experience to derive and compare power consumption between the architectures for various workloads, and eventually to support software optimizations for energy efficiency. To that end, we have performed several physical and software-based measurements of workloads from HEP applications running on ARM and Intel architectures, and compare their power consumption and performance. We leverage several profiling tools (both in hardware and software) to extract different characteristics of the power use. We report the results of these measurements and the experience gained in developing a set of measurement techniques and profiling tools to accurately assess the power consumption for scientific workloads. (paper)

Application of software quality assurance to a specific scientific code development task

International Nuclear Information System (INIS)

Dronkers, J.J.

1986-03-01

This paper describes an application of software quality assurance to a specific scientific code development program. The software quality assurance program consists of three major components: administrative control, configuration management, and user documentation. The program attempts to be consistent with existing local traditions of scientific code development while at the same time providing a controlled process of development

Advanced scientific computational methods and their applications to nuclear technologies. (3) Introduction of continuum simulation methods and their applications (3)

International Nuclear Information System (INIS)

Satake, Shin-ichi; Kunugi, Tomoaki

2006-01-01

Scientific computational methods have advanced remarkably with the progress of nuclear development. They have played the role of weft connecting each realm of nuclear engineering and then an introductory course of advanced scientific computational methods and their applications to nuclear technologies were prepared in serial form. This is the third issue showing the introduction of continuum simulation methods and their applications. Spectral methods and multi-interface calculation methods in fluid dynamics are reviewed. (T. Tanaka)

CCD developed for scientific application by Hamamatsu

CERN Document Server

Miyaguchi, K; Dezaki, J; Yamamoto, K

1999-01-01

We have developed CCDs for scientific applications that feature a low readout noise of less than 5 e-rms and low dark current of 10-25 pA/cm sup 2 at room temperature. CCDs with these characteristics will prove extremely useful in applications such as spectroscopic measurement and dental radiography. In addition, a large-area CCD of 2kx4k pixels and 15 mu m square pixel size has recently been completed for optical use in astronomical observations. Applications to X-ray astronomy require the most challenging device performance in terms of deep depletion, high CTE, and focal plane size, among others. An abuttable X-ray CCD, having 1024x1024 pixels and 24 mu m square pixel size, is to be installed in an international space station (ISS). We are now striving to achieve the lowest usable cooling temperature by means of a built-in TEC with limited power consumption. Details on the development status are described in this report. We would also like to present our future plans for a large active area and deep depleti...

Workshop on scientific and industrial applications of free electron lasers

International Nuclear Information System (INIS)

Difilippo, F.C.; Perez, R.B.

1990-05-01

A Workshop on Scientific and Industrial Applications of Free Electron Lasers was organized to address potential uses of a Free Electron Laser in the infrared wavelength region. A total of 13 speakers from national laboratories, universities, and the industry gave seminars to an average audience of 30 persons during June 12 and 13, 1989. The areas covered were: Free Electron Laser Technology, Chemistry and Surface Science, Atomic and Molecular Physics, Condensed Matter, and Biomedical Applications, Optical Damage, and Optoelectronics

A Spoken English Recognition Expert System.

Science.gov (United States)

1983-09-01

34Speech Recognition by Computer," Scientific American. New York: Scientific American, April 1981: 64-76. 16. Marcus, Mitchell P. A Theo of Syntactic...prob)...) Pcssible words for voice decoder to choose from are: gents dishes issues itches ewes folks foes comunications units eunichs error * farce

Award for Distinguished Scientific Applications of Psychology: Nancy E. Adler

Science.gov (United States)

American Psychologist, 2009

2009-01-01

Nancy E. Adler, winner of the Award for Distinguished Scientific Applications of Psychology, is cited for her research on reproductive health examining adolescent decision making with regard to contraception, conscious and preconscious motivations for pregnancy, and perception of risk for sexually transmitted diseases, and for her groundbreaking…

The graphics future in scientific applications

International Nuclear Information System (INIS)

Enderle, G.

1982-01-01

Computer graphics methods and tools are being used to a great extent in scientific research. The future development in this area will be influenced both by new hardware developments and by software advances. On the hardware sector, the development of the raster technology will lead to the increased use of colour workstations with more local processing power. Colour hardcopy devices for creating plots, slides, or movies will be available at a lower price than today. The first real 3D-workstations appear on the marketplace. One of the main activities on the software sector is the standardization of computer graphics systems, graphical files, and device interfaces. This will lead to more portable graphical application programs and to a common base for computer graphics education. (orig.)

Educational and Scientific Applications of the \\itTime Navigator}

Science.gov (United States)

Cole, M.; Snow, J. T.; Slatt, R. M.

2001-05-01

Several recent conferences have noted the need to focus on the evolving interface between research and education at all levels of science, mathematics, engineering, and technology education. This interface, which is a distinguishing feature of graduate education in the U.S., is increasingly in demand at the undergraduate and K-12 levels, particularly in the earth sciences. In this talk, we present a new database for earth systems science and will explore applications to K-12 and undergraduate education, as well as the scientific and graduate role. The University of Oklahoma, College of Geosciences is in the process of acquiring the \\itTime Navigator}, a multi-disciplinary, multimedia database, which will form the core asset of the Center for Earth Systems Science. The Center, whose mission is to further the understanding of the dynamic Earth within both the academic and the general public communities, will serve as a portal for research, information, and education for scientists and educators. \\itTime Navigator} was developed over a period of some twenty years by the noted British geoscience author, Ron Redfern, in connection with the recently published, \\itOrigins, the evolution of continents, oceans and life}, the third in a series of books for the educated layperson. Over the years \\itTime Navigator} has evolved into an interactive, multimedia database displaying much of the significant geological, paleontological, climatological, and tectonic events from the latest Proterozoic (750 MYA) through to the present. The focus is mainly on the Western Hemisphere and events associated with the coalescence and breakup of Pangea and the evolution of the earth into its present form. \\itOrigins} will be available as early as Fall 2001 as an interactive electronic book for the general, scientifically-literate public. While electronic books are unlikely to replace traditional print books, the format does allow non-linear exploration of content. We believe that the

PGC1α: Friend or Foe in Cancer?

Science.gov (United States)

Mastropasqua, Francesca; Girolimetti, Giulia; Shoshan, Maria

2018-01-22

The PGC1 family (Peroxisome proliferator-activated receptor γ (PPARγ) coactivators) of transcriptional coactivators are considered master regulators of mitochondrial biogenesis and function. The PGC1α isoform is expressed especially in metabolically active tissues, such as the liver, kidneys and brain, and responds to energy-demanding situations. Given the altered and highly adaptable metabolism of tumor cells, it is of interest to investigate PGC1α in cancer. Both high and low levels of PGC1α expression have been reported to be associated with cancer and worse prognosis, and PGC1α has been attributed with oncogenic as well as tumor suppressive features. Early in carcinogenesis PGC1α may be downregulated due to a protective anticancer role, and low levels likely reflect a glycolytic phenotype. We suggest mechanisms of PGC1α downregulation and how these might be connected to the increased cancer risk that obesity is now known to entail. Later in tumor progression PGC1α is often upregulated and is reported to contribute to increased lipid and fatty acid metabolism and/or a tumor cell phenotype with an overall metabolic plasticity that likely supports drug resistance as well as metastasis. We conclude that in cancer PGC1α is neither friend nor foe, but rather the obedient servant reacting to metabolic and environmental cues to benefit the tumor cell.

ForistomApp a Web application for scientific and technological information management of Forsitom foundation

Science.gov (United States)

Saavedra-Duarte, L. A.; Angarita-Jerardino, A.; Ruiz, P. A.; Dulce-Moreno, H. J.; Vera-Rivera, F. H.; V-Niño, E. D.

2017-12-01

Information and Communication Technologies (ICT) are essential in the transfer of knowledge, and the Web tools, as part of ICT, are important for institutions seeking greater visibility of the products developed by their researchers. For this reason, we implemented an application that allows the information management of the FORISTOM Foundation (Foundation of Researchers in Science and Technology of Materials). The application shows a detailed description, not only of all its members also of all the scientific production that they carry out, such as technological developments, research projects, articles, presentations, among others. This application can be implemented by other entities committed to the scientific dissemination and transfer of technology and knowledge.

Porting of Scientific Applications to Grid Computing on GridWay

Directory of Open Access Journals (Sweden)

J. Herrera

2005-01-01

Full Text Available The expansion and adoption of Grid technologies is prevented by the lack of a standard programming paradigm to port existing applications among different environments. The Distributed Resource Management Application API has been proposed to aid the rapid development and distribution of these applications across different Distributed Resource Management Systems. In this paper we describe an implementation of the DRMAA standard on a Globus-based testbed, and show its suitability to express typical scientific applications, like High-Throughput and Master-Worker applications. The DRMAA routines are supported by the functionality offered by the GridWay2 framework, which provides the runtime mechanisms needed for transparently executing jobs on a dynamic Grid environment based on Globus. As cases of study, we consider the implementation with DRMAA of a bioinformatics application, a genetic algorithm and the NAS Grid Benchmarks.

Kelly D. Brownell: Award for Distinguished Scientific Applications of Psychology

Science.gov (United States)

American Psychologist, 2012

2012-01-01

Presents a short biography of Kelly D. Brownwell, winner of the American Psychological Association's Award for Distinguished Scientific Applications of Psychology (2012). He won the award for outstanding contributions to our understanding of the etiology and management of obesity and the crisis it poses for the modern world. A seminal thinker in…

Secure Scientific Applications Scheduling Technique for Cloud Computing Environment Using Global League Championship Algorithm.

Science.gov (United States)

Abdulhamid, Shafi'i Muhammad; Abd Latiff, Muhammad Shafie; Abdul-Salaam, Gaddafi; Hussain Madni, Syed Hamid

2016-01-01

Cloud computing system is a huge cluster of interconnected servers residing in a datacenter and dynamically provisioned to clients on-demand via a front-end interface. Scientific applications scheduling in the cloud computing environment is identified as NP-hard problem due to the dynamic nature of heterogeneous resources. Recently, a number of metaheuristics optimization schemes have been applied to address the challenges of applications scheduling in the cloud system, without much emphasis on the issue of secure global scheduling. In this paper, scientific applications scheduling techniques using the Global League Championship Algorithm (GBLCA) optimization technique is first presented for global task scheduling in the cloud environment. The experiment is carried out using CloudSim simulator. The experimental results show that, the proposed GBLCA technique produced remarkable performance improvement rate on the makespan that ranges between 14.44% to 46.41%. It also shows significant reduction in the time taken to securely schedule applications as parametrically measured in terms of the response time. In view of the experimental results, the proposed technique provides better-quality scheduling solution that is suitable for scientific applications task execution in the Cloud Computing environment than the MinMin, MaxMin, Genetic Algorithm (GA) and Ant Colony Optimization (ACO) scheduling techniques.

Secure Scientific Applications Scheduling Technique for Cloud Computing Environment Using Global League Championship Algorithm

Science.gov (United States)

Abdulhamid, Shafi’i Muhammad; Abd Latiff, Muhammad Shafie; Abdul-Salaam, Gaddafi; Hussain Madni, Syed Hamid

2016-01-01

Cloud computing system is a huge cluster of interconnected servers residing in a datacenter and dynamically provisioned to clients on-demand via a front-end interface. Scientific applications scheduling in the cloud computing environment is identified as NP-hard problem due to the dynamic nature of heterogeneous resources. Recently, a number of metaheuristics optimization schemes have been applied to address the challenges of applications scheduling in the cloud system, without much emphasis on the issue of secure global scheduling. In this paper, scientific applications scheduling techniques using the Global League Championship Algorithm (GBLCA) optimization technique is first presented for global task scheduling in the cloud environment. The experiment is carried out using CloudSim simulator. The experimental results show that, the proposed GBLCA technique produced remarkable performance improvement rate on the makespan that ranges between 14.44% to 46.41%. It also shows significant reduction in the time taken to securely schedule applications as parametrically measured in terms of the response time. In view of the experimental results, the proposed technique provides better-quality scheduling solution that is suitable for scientific applications task execution in the Cloud Computing environment than the MinMin, MaxMin, Genetic Algorithm (GA) and Ant Colony Optimization (ACO) scheduling techniques. PMID:27384239

The native identification friend-foe of Brazil: questions and replies

Directory of Open Access Journals (Sweden)

Eric Julius Wurts

2010-09-01

Full Text Available This paper discusses the System of Identification Friend-Foe (IFF with genuinely national technology, including Mode 4 with native encryption. Actual fratricides are illustrated and the Brazilian processes to reduce them are shown. Technical aspects of IFF systems in use by the North Atlantic Treaty Organization (NATO, are reviewed and updated based on the standards of NATO Standardization Agreement (STANAG 4193. The analysis shows that the current stage of development of the industry of National Defense, coupled with its ability to integrate with the technological centers of the Armed Forces, as well as the availability of budget for research and development, resulting from the National Defense Policy, are factors for the success of the project. Also, it exposes the importance of combining air defense and air traffic control in Brazil as a determinant factor for the success of the task. The solution should be based on maintaining the standards laid down in STANAG 4193 technical characteristics of interrogators and transponders of IFF Mark XII, keeping the processes of interrogation and “response”. Results indicate the need of providing grants to study the incorporation of Mode 5 and Mode S, in a second step.

AMRZone: A Runtime AMR Data Sharing Framework For Scientific Applications

Energy Technology Data Exchange (ETDEWEB)

Zhang, Wenzhao; Tang, Houjun; Harenberg, Steven; Byna, Suren; Zou, Xiaocheng; Devendran, Dharshi; Martin, Daniel; Wu, Kesheng; Dong, Bin; Klasky, Scott; Samatova, Nagiza

2017-08-31

Frameworks that facilitate runtime data sharing across multiple applications are of great importance for scientific data analytics. Although existing frameworks work well over uniform mesh data, they can not effectively handle adaptive mesh refinement (AMR) data. Among the challenges to construct an AMR-capable framework include: (1) designing an architecture that facilitates online AMR data management; (2) achieving a load-balanced AMR data distribution for the data staging space at runtime; and (3) building an effective online index to support the unique spatial data retrieval requirements for AMR data. Towards addressing these challenges to support runtime AMR data sharing across scientific applications, we present the AMRZone framework. Experiments over real-world AMR datasets demonstrate AMRZone's effectiveness at achieving a balanced workload distribution, reading/writing large-scale datasets with thousands of parallel processes, and satisfying queries with spatial constraints. Moreover, AMRZone's performance and scalability are even comparable with existing state-of-the-art work when tested over uniform mesh data with up to 16384 cores; in the best case, our framework achieves a 46% performance improvement.

Optimal Design of Fixed-Point and Floating-Point Arithmetic Units for Scientific Applications

OpenAIRE

Pongyupinpanich, Surapong

2012-01-01

The challenge in designing a floating-point arithmetic co-processor/processor for scientific and engineering applications is to improve the performance, efficiency, and computational accuracy of the arithmetic unit. The arithmetic unit should efficiently support several mathematical functions corresponding to scientific and engineering computation demands. Moreover, the computations should be performed as fast as possible with a high degree of accuracy. Thus, this thesis proposes algorithm, d...

Scientific Applications of Optical Instruments to Materials Research

Science.gov (United States)

Witherow, William K.

1997-01-01

Microgravity is a unique environment for materials and biotechnology processing. Microgravity minimizes or eliminates some of the effects that occur in one g. This can lead to the production of new materials or crystal structures. It is important to understand the processes that create these new materials. Thus, experiments are designed so that optical data collection can take place during the formation of the material. This presentation will discuss scientific application of optical instruments at MSFC. These instruments include a near-field scanning optical microscope, a miniaturized holographic system, and a phase-shifting interferometer.

77 FR 9896 - Proposed Information Collection; Comment Request; Application and Reports for Scientific Research...

Science.gov (United States)

2012-02-21

... Collection; Comment Request; Application and Reports for Scientific Research and Enhancement Permits Under... allows permits authorizing the taking of endangered species for research/enhancement purposes. The... sets of information collections: (1) Applications for research/enhancement permits, and (2) reporting...

Performance Analysis Tool for HPC and Big Data Applications on Scientific Clusters

Energy Technology Data Exchange (ETDEWEB)

Yoo, Wucherl [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Koo, Michelle [Univ. of California, Berkeley, CA (United States); Cao, Yu [California Inst. of Technology (CalTech), Pasadena, CA (United States); Sim, Alex [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Nugent, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Wu, Kesheng [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2016-09-17

Big data is prevalent in HPC computing. Many HPC projects rely on complex workflows to analyze terabytes or petabytes of data. These workflows often require running over thousands of CPU cores and performing simultaneous data accesses, data movements, and computation. It is challenging to analyze the performance involving terabytes or petabytes of workflow data or measurement data of the executions, from complex workflows over a large number of nodes and multiple parallel task executions. To help identify performance bottlenecks or debug the performance issues in large-scale scientific applications and scientific clusters, we have developed a performance analysis framework, using state-ofthe- art open-source big data processing tools. Our tool can ingest system logs and application performance measurements to extract key performance features, and apply the most sophisticated statistical tools and data mining methods on the performance data. It utilizes an efficient data processing engine to allow users to interactively analyze a large amount of different types of logs and measurements. To illustrate the functionality of the big data analysis framework, we conduct case studies on the workflows from an astronomy project known as the Palomar Transient Factory (PTF) and the job logs from the genome analysis scientific cluster. Our study processed many terabytes of system logs and application performance measurements collected on the HPC systems at NERSC. The implementation of our tool is generic enough to be used for analyzing the performance of other HPC systems and Big Data workows.

Performance Characteristics of Hybrid MPI/OpenMP Scientific Applications on a Large-Scale Multithreaded BlueGene/Q Supercomputer

KAUST Repository

Wu, Xingfu; Taylor, Valerie

2013-01-01

In this paper, we investigate the performance characteristics of five hybrid MPI/OpenMP scientific applications (two NAS Parallel benchmarks Multi-Zone SP-MZ and BT-MZ, an earthquake simulation PEQdyna, an aerospace application PMLB and a 3D particle-in-cell application GTC) on a large-scale multithreaded Blue Gene/Q supercomputer at Argonne National laboratory, and quantify the performance gap resulting from using different number of threads per node. We use performance tools and MPI profile and trace libraries available on the supercomputer to analyze and compare the performance of these hybrid scientific applications with increasing the number OpenMP threads per node, and find that increasing the number of threads to some extent saturates or worsens performance of these hybrid applications. For the strong-scaling hybrid scientific applications such as SP-MZ, BT-MZ, PEQdyna and PLMB, using 32 threads per node results in much better application efficiency than using 64 threads per node, and as increasing the number of threads per node, the FPU (Floating Point Unit) percentage decreases, and the MPI percentage (except PMLB) and IPC (Instructions per cycle) per core (except BT-MZ) increase. For the weak-scaling hybrid scientific application such as GTC, the performance trend (relative speedup) is very similar with increasing number of threads per node no matter how many nodes (32, 128, 512) are used. © 2013 IEEE.

Performance Characteristics of Hybrid MPI/OpenMP Scientific Applications on a Large-Scale Multithreaded BlueGene/Q Supercomputer

KAUST Repository

Wu, Xingfu

2013-07-01

In this paper, we investigate the performance characteristics of five hybrid MPI/OpenMP scientific applications (two NAS Parallel benchmarks Multi-Zone SP-MZ and BT-MZ, an earthquake simulation PEQdyna, an aerospace application PMLB and a 3D particle-in-cell application GTC) on a large-scale multithreaded Blue Gene/Q supercomputer at Argonne National laboratory, and quantify the performance gap resulting from using different number of threads per node. We use performance tools and MPI profile and trace libraries available on the supercomputer to analyze and compare the performance of these hybrid scientific applications with increasing the number OpenMP threads per node, and find that increasing the number of threads to some extent saturates or worsens performance of these hybrid applications. For the strong-scaling hybrid scientific applications such as SP-MZ, BT-MZ, PEQdyna and PLMB, using 32 threads per node results in much better application efficiency than using 64 threads per node, and as increasing the number of threads per node, the FPU (Floating Point Unit) percentage decreases, and the MPI percentage (except PMLB) and IPC (Instructions per cycle) per core (except BT-MZ) increase. For the weak-scaling hybrid scientific application such as GTC, the performance trend (relative speedup) is very similar with increasing number of threads per node no matter how many nodes (32, 128, 512) are used. © 2013 IEEE.

Extracellular hemoglobin: the case of a friend turned foe

Science.gov (United States)

Quaye, Isaac K.

2015-01-01

Hemoglobin (Hb) is a highly conserved molecule present in all life forms and functionally tied to the complexity of aerobic organisms on earth in utilizing oxygen from the atmosphere and delivering to cells and tissues. This primary function sustains the energy requirements of cells and maintains cellular homeostasis. Decades of intensive research has presented a paradigm shift that shows how the molecule also functions to facilitate smooth oxygen delivery through the cardiovascular system for cellular bioenergetic homeostasis and signaling for cell function and defense. These roles are particularly highlighted in the binding of Hb to gaseous molecules carbon dioxide (CO2), nitric oxide (NO) and carbon monoxide (CO), while also serving indirectly or directly as sources of these signaling molecules. The functional activities impacted by Hb outside of bioenergetics homeostasis, include fertilization, signaling functions, modulation of inflammatory responses for defense and cell viability. These activities are efficiently executed while Hb is sequestered safely within the confines of the red blood cell (rbc). Outside of rbc confines, Hb disaggregates and becomes a danger molecule to cell survival. In these perpectives, Hb function is broadly dichotomous, either a friend in its natural environment providing and facilitating the means for cell function or foe when dislocated from its habitat under stress or pathological condition disrupting cell function. The review presents insights into how this dichotomy in function manifests. PMID:25941490

STAT3 in Cancer—Friend or Foe?

Science.gov (United States)

Zhang, Hai-Feng; Lai, Raymond

2014-01-01

The roles and significance of STAT3 in cancer biology have been extensively studied for more than a decade. Mounting evidence has shown that constitutive activation of STAT3 is a frequent biochemical aberrancy in cancer cells, and this abnormality directly contributes to tumorigenesis and shapes many malignant phenotypes in cancer cells. Nevertheless, results from more recent experimental and clinicopathologic studies have suggested that STAT3 also can exert tumor suppressor effects under specific conditions. Importantly, some of these studies have demonstrated that STAT3 can function either as an oncoprotein or a tumor suppressor in the same cell type, depending on the specific genetic background or presence/absence of specific coexisting biochemical defects. Thus, in the context of cancer biology, STAT3 can be a friend or foe. In the first half of this review, we will highlight the “evil” features of STAT3 by summarizing its oncogenic functions and mechanisms. The differences between the canonical and non-canonical pathway will be highlighted. In the second half, we will summarize the evidence supporting that STAT3 can function as a tumor suppressor. To explain how STAT3 may mediate its tumor suppressor effects, we will discuss several possible mechanisms, one of which is linked to the role of STAT3β, one of the two STAT3 splicing isoforms. Taken together, it is clear that the roles of STAT3 in cancer are multi-faceted and far more complicated than one appreciated previously. The new knowledge has provided us with new approaches and strategies when we evaluate STAT3 as a prognostic biomarker or therapeutic target. PMID:24995504

STAT3 in Cancer—Friend or Foe?

Energy Technology Data Exchange (ETDEWEB)

Zhang, Hai-Feng [Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1Z2 (Canada); The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou 515041, Guangdong (China); Lai, Raymond, E-mail: rlai@ualberta.ca [Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 1Z2 (Canada)

2014-07-03

The roles and significance of STAT3 in cancer biology have been extensively studied for more than a decade. Mounting evidence has shown that constitutive activation of STAT3 is a frequent biochemical aberrancy in cancer cells, and this abnormality directly contributes to tumorigenesis and shapes many malignant phenotypes in cancer cells. Nevertheless, results from more recent experimental and clinicopathologic studies have suggested that STAT3 also can exert tumor suppressor effects under specific conditions. Importantly, some of these studies have demonstrated that STAT3 can function either as an oncoprotein or a tumor suppressor in the same cell type, depending on the specific genetic background or presence/absence of specific coexisting biochemical defects. Thus, in the context of cancer biology, STAT3 can be a friend or foe. In the first half of this review, we will highlight the “evil” features of STAT3 by summarizing its oncogenic functions and mechanisms. The differences between the canonical and non-canonical pathway will be highlighted. In the second half, we will summarize the evidence supporting that STAT3 can function as a tumor suppressor. To explain how STAT3 may mediate its tumor suppressor effects, we will discuss several possible mechanisms, one of which is linked to the role of STAT3β, one of the two STAT3 splicing isoforms. Taken together, it is clear that the roles of STAT3 in cancer are multi-faceted and far more complicated than one appreciated previously. The new knowledge has provided us with new approaches and strategies when we evaluate STAT3 as a prognostic biomarker or therapeutic target.

The present status of scientific applications of nuclear explosions

International Nuclear Information System (INIS)

Cowan, G.A.; Diven, B.C.

1970-01-01

This is the fourth in a series of symposia which started, in 1957 at Livermore with the purpose of examining the peaceful uses of nuclear explosives. Although principal emphasis has b een placed on technological applications, the discussions have, from the outset, included the fascinating question of scientific uses. Of the possible scientific applications which were mentioned at the 1957 meeting, the proposals which attracted most attention involved uses of nuclear explosions for research in seismology. It is interesting to note that since then a very large and stimulating body of data in the field of seismology has been collected from nuclear tests. Ideas for scientific applications of nuclear explosions go back considerably further than 1957. During the war days Otto Frisch at Los Alamos suggested that a fission bomb would provide an excellent source of fast neutrons which could be led down a vacuum pipe and used for experiments in a relatively unscattered state. This idea, reinvented, modified, and elaborated upon in the ensuing twenty-five years, provides the basis for much of the research discussed in this morning's program. In 1952 a somewhat different property of nuclear explosions, their ability to produce intense neutron exposures on internal targets and to synthesize large quantities of multiple neutron capture products, was dramatically brought to our attention by analysis of debris from the first large thermonuclear explosion (Mike) in which the elements einsteinium and fermiun were observed for the first time. The reports of the next two Plowshare symposia in 1959 and 1964 help record the fascinating development of the scientific uses of neutrons in nuclear explosions. Starting with two 'wheel' experiments in 1958 to measure symmetry of fission in 235-U resonances, the use of external beams of energy-resolved neutrons was expanded on the 'Gnome' experiment in 1961 to include the measurement of neutron capture excitation functions for 238-U, 232-Th

Physics through the 1990s: Scientific interfaces and technological applications

International Nuclear Information System (INIS)

1986-01-01

Physics traditionally serves mankind through its fundamental discoveries, which enrich our understanding of nature and the cosmos. While the basic driving force for physics research is intellectual curiosity and the search for understanding, the nation's support for physics is also motivated by strategic national goals, by the pride of world scientific leadership, by societal impact through symbiosis with other natural sciences, and through the stimulus of advanced technology provided by applications of physics. This Physics Survey volume looks outward from physics to report its profound impact on society and the economy through interactions at the interfaces with other natural sciences and through applications of physics to technology, medicine, and national defense

Scientific applications of frequency-stabilized laser technology in space

Science.gov (United States)

Schumaker, Bonny L.

1990-01-01

A synoptic investigation of the uses of frequency-stabilized lasers for scientific applications in space is presented. It begins by summarizing properties of lasers, characterizing their frequency stability, and describing limitations and techniques to achieve certain levels of frequency stability. Limits to precision set by laser frequency stability for various kinds of measurements are investigated and compared with other sources of error. These other sources include photon-counting statistics, scattered laser light, fluctuations in laser power, and intensity distribution across the beam, propagation effects, mechanical and thermal noise, and radiation pressure. Methods are explored to improve the sensitivity of laser-based interferometric and range-rate measurements. Several specific types of science experiments that rely on highly precise measurements made with lasers are analyzed, and anticipated errors and overall performance are discussed. Qualitative descriptions are given of a number of other possible science applications involving frequency-stabilized lasers and related laser technology in space. These applications will warrant more careful analysis as technology develops.

Physics through the 1990s: scientific interfaces and technological applications

International Nuclear Information System (INIS)

1986-01-01

The volume examines the scientific interfaces and technological applications of physics. Twelve areas are dealt with: biological physics--biophysics, the brain, and theoretical biology; the physics-chemistry interface--instrumentation, surfaces, neutron and synchrotron radiation, polymers, organic electronic materials; materials science; geophysics--tectonics, the atmosphere and oceans, planets, drilling and seismic exploration, and remote sensing; computational physics--complex systems and applications in basic research; mathematics--field theory and chaos; microelectronics--integrated circuits, miniaturization, future trends; optical information technologies--fiber optics and photonics; instrumentation; physics applications to energy needs and the environment; national security--devices, weapons, and arms control; medical physics--radiology, ultrasonics, NMR, and photonics. An executive summary and many chapters contain recommendations regarding funding, education, industry participation, small-group university research and large facility programs, government agency programs, and computer database needs

HPC Cloud for Scientific and Business Applications: Taxonomy, Vision, and Research Challenges

OpenAIRE

Netto, Marco A. S.; Calheiros, Rodrigo N.; Rodrigues, Eduardo R.; Cunha, Renato L. F.; Buyya, Rajkumar

2017-01-01

High Performance Computing (HPC) clouds are becoming an alternative to on-premise clusters for executing scientific applications and business analytics services. Most research efforts in HPC cloud aim to understand the cost-benefit of moving resource-intensive applications from on-premise environments to public cloud platforms. Industry trends show hybrid environments are the natural path to get the best of the on-premise and cloud resources---steady (and sensitive) workloads can run on on-pr...

Performance modeling of hybrid MPI/OpenMP scientific applications on large-scale multicore supercomputers

KAUST Repository

Wu, Xingfu; Taylor, Valerie

2013-01-01

In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore supercomputers: IBM POWER4, POWER5+ and BlueGene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks and Intel's MPI benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore supercomputers because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyrokinetic Toroidal Code (GTC) in magnetic fusion to validate our performance model of the hybrid application on these multicore supercomputers. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore supercomputers. © 2013 Elsevier Inc.

Performance modeling of hybrid MPI/OpenMP scientific applications on large-scale multicore supercomputers

KAUST Repository

Wu, Xingfu

2013-12-01

In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore supercomputers: IBM POWER4, POWER5+ and BlueGene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks and Intel\\'s MPI benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore supercomputers because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyrokinetic Toroidal Code (GTC) in magnetic fusion to validate our performance model of the hybrid application on these multicore supercomputers. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore supercomputers. © 2013 Elsevier Inc.

15 CFR 301.3 - Application for duty-free entry of scientific instruments.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Application for duty-free entry of scientific instruments. 301.3 Section 301.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS...

ERAST: Scientific Applications and Technology Commercialization

Science.gov (United States)

Hunley, John D. (Compiler); Kellogg, Yvonne (Compiler)

2000-01-01

This is a conference publication for an event designed to inform potential contractors and appropriate personnel in various scientific disciplines that the ERAST (Environmental Research Aircraft and Sensor Technology) vehicles have reached a certain level of maturity and are available to perform a variety of missions ranging from data gathering to telecommunications. There are multiple applications of the technology and a great many potential commercial and governmental markets. As high altitude platforms, the ERAST vehicles can gather data at higher resolution than satellites and can do so continuously, whereas satellites pass over a particular area only once each orbit. Formal addresses are given by Rich Christiansen, (Director of Programs, NASA Aerospace Technology Ent.), Larry Roeder, (Senior Policy Advisor, U.S. Dept. of State), and Dr. Marianne McCarthy, (DFRC Education Dept.). The Commercialization Workshop is chaired by Dale Tietz (President, New Vista International) and the Science Workshop is chaired by Steve Wegener, (Deputy Manager of NASA ERAST, NASA Ames Research Center.

Scientific production on the applicability of phenytoin in wound healing

Directory of Open Access Journals (Sweden)

Flávia Firmino

2014-02-01

Full Text Available Phenytoin is an anticonvulsant that has been used in wound healing. The objectives of this study were to describe how the scientific production presents the use ofphenytoinas a healing agent and to discuss its applicability in wounds. A literature review and hierarchy analysis of evidence-based practices was performed. Eighteen articles were analyzed that tested the intervention in wounds such as leprosy ulcers, leg ulcers, diabetic foot ulcers, pressure ulcers, trophic ulcers, war wounds, burns, preparation of recipient graft area, radiodermatitis and post-extraction of melanocytic nevi. Systemic use ofphenytoinin the treatment of fistulas and the hypothesis of topical use in the treatment of vitiligo were found. In conclusion, topical use ofphenytoinis scientifically evidenced. However robust research is needed that supports a protocol for the use ofphenytoinas another option of a healing agent in clinical practice.

Predicting environmental aspects of CCSR leachates through the application of scientifically valid leaching protocols

International Nuclear Information System (INIS)

Hassett, D.J.

1993-01-01

The disposal of solid wastes from energy production, particularly solid wastes from coal conversion processes, requires a thorough understanding of the waste material as well as the disposal environment. Many coal conversion solid residues (CCSRs) have chemical, mineralogical, and physical properties advantageous for use as engineering construction materials and in other industrial applications. If disposal is to be the final disposition of CCSRs from any source, the very properties that can make ash useful also contribute to behavior that must be understood for scientifically logical and environmentally responsible disposal. This paper describes the application of scientifically valid leaching and characterization tests designed to predict field phenomena. The key to proper characterization of these unique materials is the recognition of and compensation for the hydration reactions that can occur during long-term leaching. Many of these reactions, such as the formation of the mineral ettringite, can have a profound effect on the concentration of potentially problematic trace elements such as boron, chromium, and selenium. The mobility of these elements, which may be concentrated in CCSRs due to the conversion process, must be properly evaluated for the formation of informed and scientifically sound decisions regarding safe disposal. Groundwater is an extremely important and relatively scarce resource. Contamination of this resource is a threat to life, which is highly dependent on it, so management of materials that can impact groundwater must be carefully planned and executed. The application of scientifically valid leaching protocols and complete testing are critical to proper waste management

Proceeding on the Scientific Meeting and Presentation on Accelerator Technology and Its Applications

International Nuclear Information System (INIS)

Susilo Widodo; Darsono; Slamet Santosa; Sudjatmoko; Tjipto Sujitno; Pramudita Anggraita; Wahini Nurhayati

2015-11-01

The scientific meeting and presentation on accelerator technology and its applications was held by PSTA BATAN on 30 November 2015. This meeting aims to promote the technology and its applications to accelerator scientists, academics, researchers and technology users as well as accelerator-based accelerator research that have been conducted by researchers in and outside BATAN. This proceeding contains 20 papers about physics and nuclear reactor. (PPIKSN)

Workshop on scientific applications of short wavelength coherent light sources

International Nuclear Information System (INIS)

Spicer, W.; Arthur, J.; Winick, H.

1993-02-01

This report contains paper on the following topics: A 2 to 4nm High Power FEL On the SLAC Linac; Atomic Physics with an X-ray Laser; High Resolution, Three Dimensional Soft X-ray Imaging; The Role of X-ray Induced Damage in Biological Micro-imaging; Prospects for X-ray Microscopy in Biology; Femtosecond Optical Pulses?; Research in Chemical Physics Surface Science, and Materials Science, with a Linear Accelerator Coherent Light Source; Application of 10 GeV Electron Driven X-ray Laser in Gamma-ray Laser Research; Non-Linear Optics, Fluorescence, Spectromicroscopy, Stimulated Desorption: We Need LCLS' Brightness and Time Scale; Application of High Intensity X-rays to Materials Synthesis and Processing; LCLS Optics: Selected Technological Issues and Scientific Opportunities; Possible Applications of an FEL for Materials Studies in the 60 eV to 200 eV Spectral Region

Application of BIM technology in green scientific research office building

Science.gov (United States)

Ni, Xin; Sun, Jianhua; Wang, Bo

2017-05-01

BIM technology as a kind of information technology, has been along with the advancement of building industrialization application in domestic building industry gradually. Based on reasonable construction BIM model, using BIM technology platform, through collaborative design tools can effectively improve the design efficiency and design quality. Vanda northwest engineering design and research institute co., LTD., the scientific research office building project in combination with the practical situation of engineering using BIM technology, formed in the BIM model combined with related information according to the energy energy model (BEM) and the application of BIM technology in construction management stage made exploration, and the direct experience and the achievements gained by the architectural design part made a summary.

The present status of scientific applications of nuclear explosions

Energy Technology Data Exchange (ETDEWEB)

Cowan, G A; Diven, B C [Los Alamos Scientific Laboratory, University of California, Los Alamos, NM (United States)

1970-05-15

This is the fourth in a series of symposia which started, in 1957 at Livermore with the purpose of examining the peaceful uses of nuclear explosives. Although principal emphasis has {sup b}een placed on technological applications, the discussions have, from the outset, included the fascinating question of scientific uses. Of the possible scientific applications which were mentioned at the 1957 meeting, the proposals which attracted most attention involved uses of nuclear explosions for research in seismology. It is interesting to note that since then a very large and stimulating body of data in the field of seismology has been collected from nuclear tests. Ideas for scientific applications of nuclear explosions go back considerably further than 1957. During the war days Otto Frisch at Los Alamos suggested that a fission bomb would provide an excellent source of fast neutrons which could be led down a vacuum pipe and used for experiments in a relatively unscattered state. This idea, reinvented, modified, and elaborated upon in the ensuing twenty-five years, provides the basis for much of the research discussed in this morning's program. In 1952 a somewhat different property of nuclear explosions, their ability to produce intense neutron exposures on internal targets and to synthesize large quantities of multiple neutron capture products, was dramatically brought to our attention by analysis of debris from the first large thermonuclear explosion (Mike) in which the elements einsteinium and fermiun were observed for the first time. The reports of the next two Plowshare symposia in 1959 and 1964 help record the fascinating development of the scientific uses of neutrons in nuclear explosions. Starting with two 'wheel' experiments in 1958 to measure symmetry of fission in 235-U resonances, the use of external beams of energy-resolved neutrons was expanded on the 'Gnome' experiment in 1961 to include the measurement of neutron capture excitation functions for 238-U, 232

Scientific and technical guidance for the preparation and presentation of a health claim application (Revision 2)

DEFF Research Database (Denmark)

Sjödin, Anders Mikael

2017-01-01

EFSA asked the Panel on Dietetic Products, Nutrition and Allergies (NDA) to update the scientific and technical guidance for the preparation and presentation of an application for authorisation of a health claim published in 2011. Since then, the NDA Panel has gained considerable experience...... developments in this area. This guidance document presents a common format for the organisation of information for the preparation of a well-structured application for authorisation of health claims which fall under Articles 13(5), 14 and 19 of Regulation (EC) No 1924/2006. This guidance outlines...... the information and scientific data which must be included in the application, the hierarchy of different types of data and study designs, and the key issues which should be addressed in the application to substantiate the health claim....

Proceeding of the Scientific Meeting and Presentation on Accelerator Technology and its Application

International Nuclear Information System (INIS)

Sudjatmoko; Anggraita, P.; Darsono; Sudiyanto; Kusminarto; Karyono

1999-07-01

The proceeding contains papers presented on Scientific Meeting and Presentation on Accelerator Technology and Its Application, held in Yogyakarta, 16 january 1996. This proceeding contains papers on accelerator technology, especially electron beam machine. There are 11 papers indexed individually. (ID)

Topic 14+16: High-performance and scientific applications and extreme-scale computing (Introduction)

KAUST Repository

Downes, Turlough P.

2013-01-01

As our understanding of the world around us increases it becomes more challenging to make use of what we already know, and to increase our understanding still further. Computational modeling and simulation have become critical tools in addressing this challenge. The requirements of high-resolution, accurate modeling have outstripped the ability of desktop computers and even small clusters to provide the necessary compute power. Many applications in the scientific and engineering domains now need very large amounts of compute time, while other applications, particularly in the life sciences, frequently have large data I/O requirements. There is thus a growing need for a range of high performance applications which can utilize parallel compute systems effectively, which have efficient data handling strategies and which have the capacity to utilise current and future systems. The High Performance and Scientific Applications topic aims to highlight recent progress in the use of advanced computing and algorithms to address the varied, complex and increasing challenges of modern research throughout both the "hard" and "soft" sciences. This necessitates being able to use large numbers of compute nodes, many of which are equipped with accelerators, and to deal with difficult I/O requirements. © 2013 Springer-Verlag.

Educational and Scientific Applications of Climate Model Diagnostic Analyzer

Science.gov (United States)

Lee, S.; Pan, L.; Zhai, C.; Tang, B.; Kubar, T. L.; Zhang, J.; Bao, Q.

2016-12-01

Climate Model Diagnostic Analyzer (CMDA) is a web-based information system designed for the climate modeling and model analysis community to analyze climate data from models and observations. CMDA provides tools to diagnostically analyze climate data for model validation and improvement, and to systematically manage analysis provenance for sharing results with other investigators. CMDA utilizes cloud computing resources, multi-threading computing, machine-learning algorithms, web service technologies, and provenance-supporting technologies to address technical challenges that the Earth science modeling and model analysis community faces in evaluating and diagnosing climate models. As CMDA infrastructure and technology have matured, we have developed the educational and scientific applications of CMDA. Educationally, CMDA supported the summer school of the JPL Center for Climate Sciences for three years since 2014. In the summer school, the students work on group research projects where CMDA provide datasets and analysis tools. Each student is assigned to a virtual machine with CMDA installed in Amazon Web Services. A provenance management system for CMDA is developed to keep track of students' usages of CMDA, and to recommend datasets and analysis tools for their research topic. The provenance system also allows students to revisit their analysis results and share them with their group. Scientifically, we have developed several science use cases of CMDA covering various topics, datasets, and analysis types. Each use case developed is described and listed in terms of a scientific goal, datasets used, the analysis tools used, scientific results discovered from the use case, an analysis result such as output plots and data files, and a link to the exact analysis service call with all the input arguments filled. For example, one science use case is the evaluation of NCAR CAM5 model with MODIS total cloud fraction. The analysis service used is Difference Plot Service of

Delayed repair of radiation induced clustered DNA damage: Friend or foe?

International Nuclear Information System (INIS)

Eccles, Laura J.; O'Neill, Peter; Lomax, Martine E.

2011-01-01

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base lesions, AP sites and single strand breaks. This review will concentrate on the experimental findings of the processing of non-DSB clustered damaged sites. It has been shown that non-DSB clustered damaged sites compromise the base excision repair pathway leading to the lifetime extension of the lesions within the cluster, compared to isolated lesions, thus the likelihood that the lesions persist to replication and induce mutation is increased. In addition certain non-DSB clustered damaged sites are processed within the cell to form additional DSB. The use of E. coli to demonstrate that clustering of DNA lesions is the major cause of the detrimental consequences of ionizing radiation is also discussed. The delayed repair of non-DSB clustered damaged sites in humans can be seen as a 'friend', leading to cell killing in tumour cells or as a 'foe', resulting in the formation of mutations and genetic instability in normal tissue.

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

Science.gov (United States)

Hardie, D. Grahame

2015-01-01

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status expressed in essentially all eukaryotic cells. Once activated by energetic stress via a mechanism that detects increases in AMP:ATP and ADP:ATP ratios, AMPK acts to restore energy homeostasis by switching on catabolic pathways that generate ATP, while switching off ATP-consuming processes, including anabolic pathways required for cell growth and proliferation. AMPK activation promotes the glucose-sparing, oxidative metabolism utilized by most quiescent cells, rather than the rapid glucose uptake and glycolysis used by most proliferating cells. Numerous pharmacological activators of AMPK are known, including drugs in long use such as salicylate and metformin, and there is evidence that regular use of either of the latter provides protection against development of cancer. Tumor cells appear to be under selection pressure to down-regulate AMPK, thus limiting its restraining influence on cell growth and proliferation, and several interesting mechanisms by which this occurs are discussed. Paradoxically, however, a complete loss of AMPK function, which appears to be rare in human cancers, may be deleterious to survival of tumor cells. AMPK can therefore either be a friend and a foe in cancer, depending on the context. PMID:26152739

Scientific Applications Performance Evaluation on Burst Buffer

KAUST Repository

Markomanolis, George S.

2017-10-19

Parallel I/O is an integral component of modern high performance computing, especially in storing and processing very large datasets, such as the case of seismic imaging, CFD, combustion and weather modeling. The storage hierarchy includes nowadays additional layers, the latest being the usage of SSD-based storage as a Burst Buffer for I/O acceleration. We present an in-depth analysis on how to use Burst Buffer for specific cases and how the internal MPI I/O aggregators operate according to the options that the user provides during his job submission. We analyze the performance of a range of I/O intensive scientific applications, at various scales on a large installation of Lustre parallel file system compared to an SSD-based Burst Buffer. Our results show a performance improvement over Lustre when using Burst Buffer. Moreover, we show results from a data hierarchy library which indicate that the standard I/O approaches are not enough to get the expected performance from this technology. The performance gain on the total execution time of the studied applications is between 1.16 and 3 times compared to Lustre. One of the test cases achieved an impressive I/O throughput of 900 GB/s on Burst Buffer.

Performance Modeling of Hybrid MPI/OpenMP Scientific Applications on Large-scale Multicore Cluster Systems

KAUST Repository

Wu, Xingfu; Taylor, Valerie

2011-01-01

In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore clusters: IBM POWER4, POWER5+ and Blue Gene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore clusters because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyro kinetic Toroidal Code in magnetic fusion to validate our performance model of the hybrid application on these multicore clusters. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore clusters. © 2011 IEEE.

Performance Modeling of Hybrid MPI/OpenMP Scientific Applications on Large-scale Multicore Cluster Systems

KAUST Repository

Wu, Xingfu

2011-08-01

In this paper, we present a performance modeling framework based on memory bandwidth contention time and a parameterized communication model to predict the performance of OpenMP, MPI and hybrid applications with weak scaling on three large-scale multicore clusters: IBM POWER4, POWER5+ and Blue Gene/P, and analyze the performance of these MPI, OpenMP and hybrid applications. We use STREAM memory benchmarks to provide initial performance analysis and model validation of MPI and OpenMP applications on these multicore clusters because the measured sustained memory bandwidth can provide insight into the memory bandwidth that a system should sustain on scientific applications with the same amount of workload per core. In addition to using these benchmarks, we also use a weak-scaling hybrid MPI/OpenMP large-scale scientific application: Gyro kinetic Toroidal Code in magnetic fusion to validate our performance model of the hybrid application on these multicore clusters. The validation results for our performance modeling method show less than 7.77% error rate in predicting the performance of hybrid MPI/OpenMP GTC on up to 512 cores on these multicore clusters. © 2011 IEEE.

Back-End of the web application for the scientific journal Studia Kinanthropologica

OpenAIRE

ŠIMÁK, Lubomír

2017-01-01

The bachelor thesis deals with the creation of the server part of the web application of the scientific reviewed magazine Studia Kinanthropologica, which will serve for the review of the articles for printing. The bachelor thesis describes how to work on this system and how to solve the problems that have arisen in this work.

75 FR 51439 - Proposed Information Collection; Comment Request; Application and Reports for Scientific Research...

Science.gov (United States)

2010-08-20

... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Application and Reports for Scientific Research and Enhancement Permits Under the Endangered Species Act AGENCY: National Oceanic and Atmospheric Administration (NOAA), Commerce...

Teleconference versus face-to-face scientific peer review of grant application: effects on review outcomes.

Directory of Open Access Journals (Sweden)

Stephen A Gallo

Full Text Available Teleconferencing as a setting for scientific peer review is an attractive option for funding agencies, given the substantial environmental and cost savings. Despite this, there is a paucity of published data validating teleconference-based peer review compared to the face-to-face process. Our aim was to conduct a retrospective analysis of scientific peer review data to investigate whether review setting has an effect on review process and outcome measures. We analyzed reviewer scoring data from a research program that had recently modified the review setting from face-to-face to a teleconference format with minimal changes to the overall review procedures. This analysis included approximately 1600 applications over a 4-year period: two years of face-to-face panel meetings compared to two years of teleconference meetings. The average overall scientific merit scores, score distribution, standard deviations and reviewer inter-rater reliability statistics were measured, as well as reviewer demographics and length of time discussing applications. The data indicate that few differences are evident between face-to-face and teleconference settings with regard to average overall scientific merit score, scoring distribution, standard deviation, reviewer demographics or inter-rater reliability. However, some difference was found in the discussion time. These findings suggest that most review outcome measures are unaffected by review setting, which would support the trend of using teleconference reviews rather than face-to-face meetings. However, further studies are needed to assess any correlations among discussion time, application funding and the productivity of funded research projects.

Teleconference versus Face-to-Face Scientific Peer Review of Grant Application: Effects on Review Outcomes

Science.gov (United States)

Gallo, Stephen A.; Carpenter, Afton S.; Glisson, Scott R.

2013-01-01

Teleconferencing as a setting for scientific peer review is an attractive option for funding agencies, given the substantial environmental and cost savings. Despite this, there is a paucity of published data validating teleconference-based peer review compared to the face-to-face process. Our aim was to conduct a retrospective analysis of scientific peer review data to investigate whether review setting has an effect on review process and outcome measures. We analyzed reviewer scoring data from a research program that had recently modified the review setting from face-to-face to a teleconference format with minimal changes to the overall review procedures. This analysis included approximately 1600 applications over a 4-year period: two years of face-to-face panel meetings compared to two years of teleconference meetings. The average overall scientific merit scores, score distribution, standard deviations and reviewer inter-rater reliability statistics were measured, as well as reviewer demographics and length of time discussing applications. The data indicate that few differences are evident between face-to-face and teleconference settings with regard to average overall scientific merit score, scoring distribution, standard deviation, reviewer demographics or inter-rater reliability. However, some difference was found in the discussion time. These findings suggest that most review outcome measures are unaffected by review setting, which would support the trend of using teleconference reviews rather than face-to-face meetings. However, further studies are needed to assess any correlations among discussion time, application funding and the productivity of funded research projects. PMID:23951223

The sixth Nordic conference on the application of scientific methods in archaeology

International Nuclear Information System (INIS)

1993-01-01

The Sixth Nordic Conference on the Application of Scientific Methods in Archaeology with 73 participants was convened in Esbjerg (Denmark), 19-23 September 1993. Isotope dating of archaeological, paleoecological and geochronological objects, neutron activation and XRF analytical methods, magnetometry, thermoluminescence etc. have been discussed. The program included excursions to archaeological sites and a poster session with 12 posters. (EG)

Death: a foe to be conquered? Questioning the paradigm.

Science.gov (United States)

Gellie, Anthea; Mills, Amber; Levinson, Michele; Stephenson, Gemma; Flynn, Eleanor

2015-01-01

There are few certainties in life-death is one of them. Yet death is often thought of today as the 'loss of the battle' against illness, where in traditional societies it was the natural, meaningful, end to life. Medical knowledge and technologies have extended the possibilities of medical care and increased our life span. People living in most developed countries today can expect to survive to an advanced age and die in hospital rather than at home as in the past. Owing to these and other historical, cultural and social factors, our views on death have been skewed. Medical technology provides an arsenal of weapons to launch against death and the 'war against disease' has entrenched itself in medical philosophy. We now primarily experience death through the lens of a camera. Representations of 'death as spectacle' distort our perceptions and leave us ill-prepared for the reality. Additionally, death as a natural consequence of life has become much less visible than it was in the past due to our longer life expectancies and lack of infectious disease. The continued thrust for treatment, wedded with a failure to recognise the dying process, can rob individuals of a peaceful, dignified death. Progress being made in Advance Care Planning and palliative care is limited by the existing paradigm of death as a 'foe to be conquered'. It is time for a shift in this paradigm. © The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Scientific basis of development and application of nanotechnologies in oil industry

International Nuclear Information System (INIS)

Mirzajanzadeh, A.; Maharramov, A.; Abdullayev, R.; Yuzifzadeh, Kh.; Shahbazov, E.; Qurbanov, R.; Akhmadov, S.; Kazimov, E; Ramazanov, M.; Shafiyev, Sh.; Hajizadeh, N.

2010-01-01

Development and introduction of nanotechnologies in the oil industry is one of the most pressing issues of the present times.For the first time in the world practice scientific-methodological basis and application practice of nanotechnologies in oil industry is developed on the basis of uniform, scientifically proven approach by taking into account the specificities of oil and gas industry.The application system of such nanotechnologies was developed in oil and gas production.Mathematical models of nanotechnological processes, i.e. c haos regulation a nd hyper-accidental process were offered. Nanomedium and nanoimpact on the w ell-layer s ystem was studied. Wide application results of nanotechnologies in SOCAR's production fields in oil and gas production are shown.Research results of N ANOSAA o n the basis of N ANO + NANO e ffect are described in the development.For the first time in world practice N ANOOIL , N ANOBITUMEN , N ANOGUDRON' and N ANOMAY' systems on the basis of machine waste oil in the drilling mud were developed for the application in oil and gas drilling. Original property, e ffect of super small concentrations a nd n anomemory i n N ANOOIL a nd N ANOBITUMEN s ystems was discovered.By applying N ANOOIL , N ANOBITUMEN a nd N ANOMAY s ystems in the drilling process was discovered: the increase of linear speed, early turbulence, decrease of hydraulic resistance coefficient and economy in energy consumption.Hyper-accidental evaluation of mathematical expectation of general sum of values of the surface strain on the sample data is spelled out with the various experiment conditions. Estimated hyper-accidental value of the mathematical expectation allows us to offer practical recommendations for the development of new nanotechnologies on the basis of rheological parameters of oil.

Scientific Ethics: A New Approach.

Science.gov (United States)

Menapace, Marcello

2018-06-04

Science is an activity of the human intellect and as such has ethical implications that should be reviewed and taken into account. Although science and ethics have conventionally been considered different, it is herewith proposed that they are essentially similar. The proposal set henceforth is to create a new ethics rooted in science: scientific ethics. Science has firm axiological foundations and searches for truth (as a value, axiology) and knowledge (epistemology). Hence, science cannot be value neutral. Looking at standard scientific principles, it is possible to construct a scientific ethic (that is, an ethical framework based on scientific methods and rules), which can be applied to all sciences. These intellectual standards include the search for truth (honesty and its derivatives), human dignity (and by reflection the dignity of all animals) and respect for life. Through these it is thence achievable to draft a foundation of a ethics based purely on science and applicable beyond the confines of science. A few applications of these will be presented. Scientific ethics can have vast applications in other fields even in non scientific ones.

78 FR 13860 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2013-03-01

... Scientific Instruments Pursuant to Section 6(c) of the Educational, Scientific and Cultural Materials... invite comments on the question of whether instruments of equivalent scientific value, for the purposes... conformational change of assemblies involved in biological processes such as ATP production, signal transduction...

76 FR 56156 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2011-09-12

... Scientific Instruments Pursuant to Section 6(c) of the Educational, Scientific and Cultural Materials... invite comments on the question of whether instruments of equivalent scientific value, for the purposes... materials for energy production. The experiments will involve structural and chemical analyses of materials...

BurstMem: A High-Performance Burst Buffer System for Scientific Applications

Energy Technology Data Exchange (ETDEWEB)

Wang, Teng [Auburn University, Auburn, Alabama; Oral, H Sarp [ORNL; Wang, Yandong [Auburn University, Auburn, Alabama; Settlemyer, Bradley W [ORNL; Atchley, Scott [ORNL; Yu, Weikuan [Auburn University, Auburn, Alabama

2014-01-01

The growth of computing power on large-scale sys- tems requires commensurate high-bandwidth I/O system. Many parallel file systems are designed to provide fast sustainable I/O in response to applications soaring requirements. To meet this need, a novel system is imperative to temporarily buffer the bursty I/O and gradually flush datasets to long-term parallel file systems. In this paper, we introduce the design of BurstMem, a high- performance burst buffer system. BurstMem provides a storage framework with efficient storage and communication manage- ment strategies. Our experiments demonstrate that BurstMem is able to speed up the I/O performance of scientific applications by up to 8.5 on leadership computer systems.

Proceedings of the Scientific Meeting on Research and Development of Isotopes Application and Radiation

International Nuclear Information System (INIS)

Singgih Sutrisno; Sofyan Yatim; Pattiradjawane, EIsje L.; Ismachin, Moch; Mugiono; Marga Utama; Komaruddin Idris

2004-02-01

The Proceedings of Scientific Meeting on Research and Development of Isotopes Application and Radiation has been presented on February 17-18, 2004 in Jakarta. The aims of the Meeting is to disseminate the results of research on application of nuclear techniques on agricultural, animal, industry, hydrology and environment. There were 4 invited papers and 38 papers from BATAN participants as well as outside. The articles are indexing separately. (PPIN)

Cloud Data Storage Federation for Scientific Applications

NARCIS (Netherlands)

Koulouzis, S.; Vasyunin, D.; Cushing, R.; Belloum, A.; Bubak, M.; an Mey, D.; Alexander, M.; Bientinesi, P.; Cannataro, M.; Clauss, C.; Costan, A.; Kecskemeti, G.; Morin, C.; Ricci, L.; Sahuquillo, J.; Schulz, M.; Scarano, V.; Scott, S.L.; Weidendorfer, J.

2014-01-01

Nowadays, data-intensive scientific research needs storage capabilities that enable efficient data sharing. This is of great importance for many scientific domains such as the Virtual Physiological Human. In this paper, we introduce a solution that federates a variety of systems ranging from file

Accelerating the scientific exploration process with scientific workflows

International Nuclear Information System (INIS)

Altintas, Ilkay; Barney, Oscar; Cheng, Zhengang; Critchlow, Terence; Ludaescher, Bertram; Parker, Steve; Shoshani, Arie; Vouk, Mladen

2006-01-01

Although an increasing amount of middleware has emerged in the last few years to achieve remote data access, distributed job execution, and data management, orchestrating these technologies with minimal overhead still remains a difficult task for scientists. Scientific workflow systems improve this situation by creating interfaces to a variety of technologies and automating the execution and monitoring of the workflows. Workflow systems provide domain-independent customizable interfaces and tools that combine different tools and technologies along with efficient methods for using them. As simulations and experiments move into the petascale regime, the orchestration of long running data and compute intensive tasks is becoming a major requirement for the successful steering and completion of scientific investigations. A scientific workflow is the process of combining data and processes into a configurable, structured set of steps that implement semi-automated computational solutions of a scientific problem. Kepler is a cross-project collaboration, co-founded by the SciDAC Scientific Data Management (SDM) Center, whose purpose is to develop a domain-independent scientific workflow system. It provides a workflow environment in which scientists design and execute scientific workflows by specifying the desired sequence of computational actions and the appropriate data flow, including required data transformations, between these steps. Currently deployed workflows range from local analytical pipelines to distributed, high-performance and high-throughput applications, which can be both data- and compute-intensive. The scientific workflow approach offers a number of advantages over traditional scripting-based approaches, including ease of configuration, improved reusability and maintenance of workflows and components (called actors), automated provenance management, 'smart' re-running of different versions of workflow instances, on-the-fly updateable parameters, monitoring

Application of quality assurance to scientific activities at Westinghouse Hanford Company

International Nuclear Information System (INIS)

Delvin, W.L.; Farwick, D.G.

1988-01-01

The application of quality assurance to scientific activities has been an ongoing subject of review, discussion, interpretation, and evaluation within the nuclear community for the past several years. This paper provides a discussion on the natures of science and quality assurance and presents suggestions for integrating the two successfully. The paper shows how those actions were used at the Westinghouse Hanford Company to successfully apply quality assurance to experimental studies and materials testing and evaluation activities that supported a major project. An important factor in developing and implementing the quality assurance program was the close working relationship that existed between the assigned quality engineers and the scientists. The quality engineers, who had had working experience in the scientific disciplines involved, were able to bridge across from the scientists to the more traditional quality assurance personnel who had overall responsibility for the project's quality assurance program

Leveraging Transcultural Enrollments to Enhance Application of the Scientific Method

Science.gov (United States)

Loudin, M.

2013-12-01

Continued growth of transcultural academic programs presents an opportunity for all of the students involved to improve utilization of the scientific method. Our own business success depends on how effectively we apply the scientific method, and so it is unsurprising that our hiring programs focus on three broad areas of capability among applicants which are strongly related to the scientific method. These are 1) ability to continually learn up-to-date earth science concepts, 2) ability to effectively and succinctly communicate in the English language, both oral and written, and 3) ability to employ behaviors that are advantageous with respect to the various phases of the scientific method. This third area is often the most difficult to develop, because neither so-called Western nor Eastern cultures encourage a suite of behaviors that are ideally suited. Generally, the acceptance of candidates into academic programs, together with subsequent high performance evidenced by grades, is a highly valid measure of continuous learning capability. Certainly, students for whom English is not a native language face additional challenges, but succinct and effective communication is an art which requires practice and development, regardless of native language. The ability to communicate in English is crucial, since it is today's lingua franca for both science and commerce globally. Therefore, we strongly support the use of frequent English written assignments and oral presentations as an integral part of all scientific academic programs. There is no question but that this poses additional work for faculty; nevertheless it is a key ingredient to the optimal development of students. No one culture has a monopoly with respect to behaviors that promote effective leveraging of the scientific method. For instance, the growing complexity of experimental protocols argues for a high degree of interdependent effort, which is more often associated with so-called Eastern than Western

Applications of scientific imaging in environmental toxicology

Science.gov (United States)

El-Demerdash, Aref M.

The national goals of clean air, clean water, and healthy ecosystems are a few of the primary forces that drive the need for better environmental monitoring. As we approach the end of the 1990s, the environmental questions at regional to global scales are being redefined and refined in the light of developments in environmental understanding and technological capability. Research in the use of scientific imaging data for the study of the environment is urgently needed in order to explore the possibilities of utilizing emerging new technologies. The objective of this research proposal is to demonstrate the usability of a wealth of new technology made available in the last decade to providing a better understanding of environmental problems. Research is focused in two imaging techniques macro and micro imaging. Several examples of applications of scientific imaging in research in the field of environmental toxicology were presented. This was achieved on two scales, micro and macro imaging. On the micro level four specific examples were covered. First, the effect of utilizing scanning electron microscopy as an imaging tool in enhancing taxa identification when studying diatoms was presented. Second, scanning electron microscopy combined with energy dispersive x-ray analyzer were demonstrated as a valuable and effective tool for identifying and analyzing household dust samples. Third, electronic autoradiography combined with FT-IR microscopy were used to study the distribution pattern of [14C]-Malathion in rats as a result of dermal exposure. The results of the autoradiography made on skin sections of the application site revealed the presence of [ 14C]-activity in the first region of the skin. These results were evidenced by FT-IR microscopy. The obtained results suggest that the penetration of Malathion into the skin and other tissues is vehicle and dose dependent. The results also suggest the use of FT-IR microscopy imaging for monitoring the disposition of

Efficient Machine Learning Approach for Optimizing Scientific Computing Applications on Emerging HPC Architectures

Energy Technology Data Exchange (ETDEWEB)

Arumugam, Kamesh [Old Dominion Univ., Norfolk, VA (United States)

2017-05-01

Efficient parallel implementations of scientific applications on multi-core CPUs with accelerators such as GPUs and Xeon Phis is challenging. This requires - exploiting the data parallel architecture of the accelerator along with the vector pipelines of modern x86 CPU architectures, load balancing, and efficient memory transfer between different devices. It is relatively easy to meet these requirements for highly structured scientific applications. In contrast, a number of scientific and engineering applications are unstructured. Getting performance on accelerators for these applications is extremely challenging because many of these applications employ irregular algorithms which exhibit data-dependent control-ow and irregular memory accesses. Furthermore, these applications are often iterative with dependency between steps, and thus making it hard to parallelize across steps. As a result, parallelism in these applications is often limited to a single step. Numerical simulation of charged particles beam dynamics is one such application where the distribution of work and memory access pattern at each time step is irregular. Applications with these properties tend to present significant branch and memory divergence, load imbalance between different processor cores, and poor compute and memory utilization. Prior research on parallelizing such irregular applications have been focused around optimizing the irregular, data-dependent memory accesses and control-ow during a single step of the application independent of the other steps, with the assumption that these patterns are completely unpredictable. We observed that the structure of computation leading to control-ow divergence and irregular memory accesses in one step is similar to that in the next step. It is possible to predict this structure in the current step by observing the computation structure of previous steps. In this dissertation, we present novel machine learning based optimization techniques to address

Methods for Specifying Scientific Data Standards and Modeling Relationships with Applications to Neuroscience

Science.gov (United States)

Rübel, Oliver; Dougherty, Max; Prabhat; Denes, Peter; Conant, David; Chang, Edward F.; Bouchard, Kristofer

2016-01-01

Neuroscience continues to experience a tremendous growth in data; in terms of the volume and variety of data, the velocity at which data is acquired, and in turn the veracity of data. These challenges are a serious impediment to sharing of data, analyses, and tools within and across labs. Here, we introduce BRAINformat, a novel data standardization framework for the design and management of scientific data formats. The BRAINformat library defines application-independent design concepts and modules that together create a general framework for standardization of scientific data. We describe the formal specification of scientific data standards, which facilitates sharing and verification of data and formats. We introduce the concept of Managed Objects, enabling semantic components of data formats to be specified as self-contained units, supporting modular and reusable design of data format components and file storage. We also introduce the novel concept of Relationship Attributes for modeling and use of semantic relationships between data objects. Based on these concepts we demonstrate the application of our framework to design and implement a standard format for electrophysiology data and show how data standardization and relationship-modeling facilitate data analysis and sharing. The format uses HDF5, enabling portable, scalable, and self-describing data storage and integration with modern high-performance computing for data-driven discovery. The BRAINformat library is open source, easy-to-use, and provides detailed user and developer documentation and is freely available at: https://bitbucket.org/oruebel/brainformat. PMID:27867355

Applications of industrial computed tomography at Los Alamos Scientific Laboratory

International Nuclear Information System (INIS)

Kruger, R.P.; Morris, R.A.; Wecksung, G.W.

1980-01-01

A research and development program was begun three years ago at the Los Alamos Scientific Laboratory (LASL) to study nonmedical applications of computed tomography. This program had several goals. The first goal was to develop the necessary reconstruction algorithms to accurately reconstruct cross sections of nonmedical industrial objects. The second goal was to be able to perform extensive tomographic simulations to determine the efficacy of tomographic reconstruction with a variety of hardware configurations. The final goal was to construct an inexpensive industrial prototype scanner with a high degree of design flexibility. The implementation of these program goals is described

Methylphenidate effects in the young brain: friend or foe?

Science.gov (United States)

Loureiro-Vieira, Sara; Costa, Vera Marisa; de Lourdes Bastos, Maria; Carvalho, Félix; Capela, João Paulo

2017-08-01

Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and methylphenidate (MPH) is a first-line stimulant drug available worldwide for its treatment. Despite the proven therapeutic efficacy, concerns have been raised regarding the possible consequences of chronic MPH exposure during childhood and adolescence. Disturbances in the neurodevelopment at these crucial stages are major concerns given the unknown future life consequences. This review is focused on the long-term adverse effects of MPH to the brain biochemistry. Reports conducted with young and/or adolescent animals and studies with humans are reviewed in the context of long-term consequences after early life-exposure. MPH pharmacokinetics is also reviewed as there are differences among laboratory animals and humans that may be relevant to extrapolate the findings. Studies reveal that exposure to MPH in laboratory animals during young and/or adolescent ages can impact the brain, but the outcomes are dependent on MPH dose, treatment period, and animal's age. Importantly, the female sex is largely overlooked in both animal and human studies. Unfortunately, human reports that evaluate adults following adolescent or child exposure to MPH are very scarce. In general, human data indicates that MPH is generally safe, although it can promote several brain changes in early ages. Even so, there is a lack of long course patient evaluation to clearly establish whether MPH-induced changes are friendly or foe to the brain and more human studies are needed to assess the adult brain changes that arise from early MPH treatment. Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.

GRID Prototype for imagery processing in scientific applications

International Nuclear Information System (INIS)

Stan, Ionel; Zgura, Ion Sorin; Haiduc, Maria; Valeanu, Vlad; Giurgiu, Liviu

2004-01-01

The paper presents the results of our study which is part of the InGRID project. This project is supported by ROSA (ROmanian Space Agency). In this paper we will show the possibility to take images from the optical microscope through web camera. The images are then stored on the PC in Linux operating system and distributed to other clusters through GRID technology (using http, php, MySQL, Globus or AliEn systems). The images are provided from nuclear emulsions in the frame of Becquerel Collaboration. The main goal of the project InGRID is to actuate developing and deploying GRID technology for images technique taken from space, different application fields and telemedicine. Also it will create links with the same international projects which use advanced Grid technology and scalable storage solutions. The main topics proposed to be solved in the frame of InGRID project are: - Implementation of two GRID clusters, minimum level Tier 3; - Adapting and updating the common storage and processing computing facility; - Testing the middelware packages developed in the frame of this project; - Testbed production of the prototype; - Build-up and advertise the InGRID prototype in scientific community through current dissemination. InGRID Prototype developed in the frame of this project, will be used by partner institutes as deploying environment of the imaging applications the dynamical features of which will be defined by conditions of contract. Subsequent applications will be deployed by the partners of this project with governmental, nongovernmental and private institutions. (authors)

Efficient Use of Distributed Systems for Scientific Applications

Science.gov (United States)

Taylor, Valerie; Chen, Jian; Canfield, Thomas; Richard, Jacques

2000-01-01

Distributed computing has been regarded as the future of high performance computing. Nationwide high speed networks such as vBNS are becoming widely available to interconnect high-speed computers, virtual environments, scientific instruments and large data sets. One of the major issues to be addressed with distributed systems is the development of computational tools that facilitate the efficient execution of parallel applications on such systems. These tools must exploit the heterogeneous resources (networks and compute nodes) in distributed systems. This paper presents a tool, called PART, which addresses this issue for mesh partitioning. PART takes advantage of the following heterogeneous system features: (1) processor speed; (2) number of processors; (3) local network performance; and (4) wide area network performance. Further, different finite element applications under consideration may have different computational complexities, different communication patterns, and different element types, which also must be taken into consideration when partitioning. PART uses parallel simulated annealing to partition the domain, taking into consideration network and processor heterogeneity. The results of using PART for an explicit finite element application executing on two IBM SPs (located at Argonne National Laboratory and the San Diego Supercomputer Center) indicate an increase in efficiency by up to 36% as compared to METIS, a widely used mesh partitioning tool. The input to METIS was modified to take into consideration heterogeneous processor performance; METIS does not take into consideration heterogeneous networks. The execution times for these applications were reduced by up to 30% as compared to METIS. These results are given in Figure 1 for four irregular meshes with number of elements ranging from 30,269 elements for the Barth5 mesh to 11,451 elements for the Barth4 mesh. Future work with PART entails using the tool with an integrated application requiring

Emerging Nanophotonic Applications Explored with Advanced Scientific Parallel Computing

Science.gov (United States)

Meng, Xiang

The domain of nanoscale optical science and technology is a combination of the classical world of electromagnetics and the quantum mechanical regime of atoms and molecules. Recent advancements in fabrication technology allows the optical structures to be scaled down to nanoscale size or even to the atomic level, which are far smaller than the wavelength they are designed for. These nanostructures can have unique, controllable, and tunable optical properties and their interactions with quantum materials can have important near-field and far-field optical response. Undoubtedly, these optical properties can have many important applications, ranging from the efficient and tunable light sources, detectors, filters, modulators, high-speed all-optical switches; to the next-generation classical and quantum computation, and biophotonic medical sensors. This emerging research of nanoscience, known as nanophotonics, is a highly interdisciplinary field requiring expertise in materials science, physics, electrical engineering, and scientific computing, modeling and simulation. It has also become an important research field for investigating the science and engineering of light-matter interactions that take place on wavelength and subwavelength scales where the nature of the nanostructured matter controls the interactions. In addition, the fast advancements in the computing capabilities, such as parallel computing, also become as a critical element for investigating advanced nanophotonic devices. This role has taken on even greater urgency with the scale-down of device dimensions, and the design for these devices require extensive memory and extremely long core hours. Thus distributed computing platforms associated with parallel computing are required for faster designs processes. Scientific parallel computing constructs mathematical models and quantitative analysis techniques, and uses the computing machines to analyze and solve otherwise intractable scientific challenges. In

Friends and Foes from an Ant Brain's Point of View – Neuronal Correlates of Colony Odors in a Social Insect

Science.gov (United States)

Brandstaetter, Andreas Simon; Rössler, Wolfgang; Kleineidam, Christoph Johannes

2011-01-01

Background Successful cooperation depends on reliable identification of friends and foes. Social insects discriminate colony members (nestmates/friends) from foreign workers (non-nestmates/foes) by colony-specific, multi-component colony odors. Traditionally, complex processing in the brain has been regarded as crucial for colony recognition. Odor information is represented as spatial patterns of activity and processed in the primary olfactory neuropile, the antennal lobe (AL) of insects, which is analogous to the vertebrate olfactory bulb. Correlative evidence indicates that the spatial activity patterns reflect odor-quality, i.e., how an odor is perceived. For colony odors, alternatively, a sensory filter in the peripheral nervous system was suggested, causing specific anosmia to nestmate colony odors. Here, we investigate neuronal correlates of colony odors in the brain of a social insect to directly test whether they are anosmic to nestmate colony odors and whether spatial activity patterns in the AL can predict how odor qualities like “friend” and “foe” are attributed to colony odors. Methodology/Principal Findings Using ant dummies that mimic natural conditions, we presented colony odors and investigated their neuronal representation in the ant Camponotus floridanus. Nestmate and non-nestmate colony odors elicited neuronal activity: In the periphery, we recorded sensory responses of olfactory receptor neurons (electroantennography), and in the brain, we measured colony odor specific spatial activity patterns in the AL (calcium imaging). Surprisingly, upon repeated stimulation with the same colony odor, spatial activity patterns were variable, and as variable as activity patterns elicited by different colony odors. Conclusions Ants are not anosmic to nestmate colony odors. However, spatial activity patterns in the AL alone do not provide sufficient information for colony odor discrimination and this finding challenges the current notion of how odor

Scientific and technical guidance for the preparation and presentation of an application for authorisation of a health claim (revision 1)

DEFF Research Database (Denmark)

Tetens, Inge

2011-01-01

The scientific and technical guidance of the EFSA Panel on Dietetic Products, Nutrition and Allergies for the preparation and presentation of an application for authorisation of a health claim presents a common format for the organisation of information for the preparation of a well......-structured application for authorisation of health claims which fall under Article 14 (referring to children’s development and health, and to disease risk reduction claims), or 13(5) (which are based on newly developed scientific evidence and/or which include a request for the protection of proprietary data......), or for the modification of an existing authorisation in accordance with Article 19 of Regulation (EC) No 1924/2006 on nutrition and health claims made on foods. This guidance outlines: the information and scientific data which must be included in the application, the hierarchy of different types of data and study designs...

The Organizational-Legal Peculiarities of Application of the Remote Labor Mode and Flexible Working Hours of Scientific Workers at Higher Education Institution

Directory of Open Access Journals (Sweden)

Lytovchenko Iryna V.

2018-01-01

Full Text Available The article is aimed at defining the main organizational-legal peculiarities of application of the remote labor mode, establishing and accounting the flexible working hours of scientific workers at higher educational institutions and scientific institutes. In the course of research the organizational-legal peculiarities of application of the remote labor mode and flexible working hours of the scientific workers at higher education institutions were analyzed. The article suggests their integration into the activities of higher education institution with the purpose of efficient distribution of their working time, provided that the tasks set are fully executed in a timely manner. As the basic means of control of measurement of results of scientific activity it is suggested to use acts of executed works and other absolute indicators (quantity of the processed scientific sources, quantity of the written pages of scientific papers etc.. The prospective direction of further research is development of practical recommendations on the use of special reports and indicators with an assessment of their impact on the results of activities of scientific workers at higher education institutions.

Proceeding on the scientific meeting and presentation on accelerator technology and its applications: physics, nuclear reactor

International Nuclear Information System (INIS)

Pramudita Anggraita; Sudjatmoko; Darsono; Tri Marji Atmono; Tjipto Sujitno; Wahini Nurhayati

2012-01-01

The scientific meeting and presentation on accelerator technology and its applications was held by PTAPB BATAN on 13 December 2011. This meeting aims to promote the technology and its applications to accelerator scientists, academics, researchers and technology users as well as accelerator-based accelerator research that have been conducted by researchers in and outside BATAN. This proceeding contains 23 papers about physics and nuclear reactor. (PPIKSN)

Results of data base management system parameterized performance testing related to GSFC scientific applications

Science.gov (United States)

Carchedi, C. H.; Gough, T. L.; Huston, H. A.

1983-01-01

The results of a variety of tests designed to demonstrate and evaluate the performance of several commercially available data base management system (DBMS) products compatible with the Digital Equipment Corporation VAX 11/780 computer system are summarized. The tests were performed on the INGRES, ORACLE, and SEED DBMS products employing applications that were similar to scientific applications under development by NASA. The objectives of this testing included determining the strength and weaknesses of the candidate systems, performance trade-offs of various design alternatives and the impact of some installation and environmental (computer related) influences.

Scientific evaluation at the CEA

International Nuclear Information System (INIS)

1999-01-01

This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1998. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 5 parts dealing successively with: part 1 - the CEA, a public research organization (civil nuclear research, technology research and transfers, defence activities); the scientific and technical evaluation at the CEA (general framework, evaluation of the IPSN and DAM); part 2 - the scientific and technical councils (directions of fuel cycle, of nuclear reactors, and of advanced technologies); part 3 - the scientific councils (directions of matter and of life sciences); the nuclear protection and safety institute; the direction of military applications; part 4 - the corresponding members of the evaluation; part 5 - the list of scientific and technical councils and members. (J.S.)

78 FR 27186 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2013-05-09

... Scientific Instruments Pursuant to Section 6(c) of the Educational, Scientific and Cultural Materials...: New Mexico Institute of Mining and Technology, 801 Leroy Place, Socorro, NM 87801. Instrument: Delay... dimensions. The experiments depend on this fast 3D scanning to capture sufficient data from the dendrites of...

AGEs, RAGEs and s-RAGE; friend or foe for cancer.

Science.gov (United States)

Ahmad, Saheem; Khan, Hamda; Siddiqui, Zeba; Khan, Mohd Yasir; Rehman, Shahnawaz; Shahab, Uzma; Godovikova, Tatyana; Silnikov, Vladimir; Moinuddin

2018-04-01

Impaired awareness of glycation biology in cancer initiation and progression is one of the fundamental reasons for its meticulous investigation of the molecules involved in signalling pathway. Glycation of biological macromolecules results in the progression of advanced glycation end-products (AGEs) that proliferates the process of carcinogenesis by activation of transcription factors and release of cytokines. The receptor for advanced glycation end-products (RAGEs) with the binding of its different ligands like; AGEs, HMGB1 and S100 activate the signalling arrays. The activation of downstream signalling pathway ultimately leads to the pathophysiological conditions of diabetes, ageing, neurological disorders and cancers as well as a result of the activation of transcription factors which is discussed in the main body text of this review. However, there might be a likelihood of the positive effect of the HMGB1 and S100 proteins in cancer. Still, some untouched mechanisms might be responsible for the establishment of the function of AGE-RAGE or AGE-sRAGE axis activation that leads to the friend-foe association with the cancers. The levels of RAGE and s-RAGE may be a useful biomarker of ligand-RAGE pathway activation and cancer. Thus, the possibility of providing a potential complement to carcinogenesis is very high which might be an interesting target for therapeutic interventions. This article is an insightful assessment on AGE, RAGE and s-RAGE for its possible role in cancer onset and progression. The novel therapeutic targets for cancer prevention or inhibition are also explained in brief in relation to AGE and RAGE. Copyright © 2017 Elsevier Ltd. All rights reserved.

Scientific and Technological Report 2011

International Nuclear Information System (INIS)

Lopez Milla, Alcides; Prado Cuba, Antonio; Agapito Panta, Juan; Montoya Rossi, Eduardo

2013-01-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2011. This report includes 30 papers divided in 8 subject matters, such as: physics and chemistry, materials science, nuclear engineering, mining industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, scientific instrumentation and management aspects. It also includes annexes. (APC)

Scientific and Technological Report 2010

International Nuclear Information System (INIS)

Prado Cuba, Antonio; Santiago Contreras, Julio; Solis Veliz, Jose; Lopez Moreno, Edith

2011-10-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2010. This report includes 41 papers divided in 8 subject matters, such as: physics and chemistry, materials science, nuclear engineering, mining industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, scientific instrumentation and management aspects. It also includes annexes. (APC)

α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2.

Science.gov (United States)

Li, Xiao-Jun; Yang, Yan-Jing; Li, Yu-Sang; Zhang, Wei Kevin; Tang, He-Bin

2016-02-17

Frankincense oil and water extracts (FOE, FWE) have long been used for external treatment of inflammation and pain. The present study was conducted to identify the active ingredients responsible for the anti-inflammatory and analgesic effects and to determine the underlying mechanisms. The compositions of FOE and FWE were identified and compared by GC-MS. The anti-inflammatory and analgesic activities of the two extracts and their possible active ingredients (α-pinene, linalool, and 1-octanol) were evaluated and compared in a xylene-induced ear edema model and a formalin-inflamed hind paw model. Inflammatory infiltrates and cyclooxygenase-2 (COX-2) expression in hind paw skin were investigated by histological staining. The contents of α-pinene, linalool, and 1-octanol in FOE were much higher than those in FWE. Mice treated with FOE exhibited greater and faster lessening of swelling and pain than mice treated with FWE. The combination of the three components had more potent pharmacological effects on hind paw inflammation and COX-2 overexpression than the three components used alone. These findings suggest that topical application of FOE or its active ingredients (including α-pinene, linalool, and 1-octanol) exhibit significantly anti-inflammatory and analgesic effects through inhibiting nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The StratusLab cloud distribution: Use-cases and support for scientific applications

Science.gov (United States)

Floros, E.

2012-04-01

The StratusLab project is integrating an open cloud software distribution that enables organizations to setup and provide their own private or public IaaS (Infrastructure as a Service) computing clouds. StratusLab distribution capitalizes on popular infrastructure virtualization solutions like KVM, the OpenNebula virtual machine manager, Claudia service manager and SlipStream deployment platform, which are further enhanced and expanded with additional components developed within the project. The StratusLab distribution covers the core aspects of a cloud IaaS architecture, namely Computing (life-cycle management of virtual machines), Storage, Appliance management and Networking. The resulting software stack provides a packaged turn-key solution for deploying cloud computing services. The cloud computing infrastructures deployed using StratusLab can support a wide range of scientific and business use cases. Grid computing has been the primary use case pursued by the project and for this reason the initial priority has been the support for the deployment and operation of fully virtualized production-level grid sites; a goal that has already been achieved by operating such a site as part of EGI's (European Grid Initiative) pan-european grid infrastructure. In this area the project is currently working to provide non-trivial capabilities like elastic and autonomic management of grid site resources. Although grid computing has been the motivating paradigm, StratusLab's cloud distribution can support a wider range of use cases. Towards this direction, we have developed and currently provide support for setting up general purpose computing solutions like Hadoop, MPI and Torque clusters. For what concerns scientific applications the project is collaborating closely with the Bioinformatics community in order to prepare VM appliances and deploy optimized services for bioinformatics applications. In a similar manner additional scientific disciplines like Earth Science can take

State of the art of parallel scientific visualization applications on PC clusters

International Nuclear Information System (INIS)

Juliachs, M.

2004-01-01

In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

Historic Learning Approach for Auto-tuning OpenACC Accelerated Scientific Applications

KAUST Repository

Siddiqui, Shahzeb

2015-04-17

The performance optimization of scientific applications usually requires an in-depth knowledge of the hardware and software. A performance tuning mechanism is suggested to automatically tune OpenACC parameters to adapt to the execution environment on a given system. A historic learning based methodology is suggested to prune the parameter search space for a more efficient auto-tuning process. This approach is applied to tune the OpenACC gang and vector clauses for a better mapping of the compute kernels onto the underlying architecture. Our experiments show a significant performance improvement against the default compiler parameters and drastic reduction in tuning time compared to a brute force search-based approach.

First scientific application of the membrane cryostat technology

Energy Technology Data Exchange (ETDEWEB)

Montanari, David; Adamowski, Mark; Baller, Bruce R.; Barger, Robert K.; Chi, Edward C.; Davis, Ronald P.; Johnson, Bryan D.; Kubinski, Bob M.; Najdzion, John J.; Rucinski, Russel A.; Schmitt, Rich L.; Tope, Terry E. [Particle Physics Division, Fermilab, P.O. Box 500, Batavia, IL 60510 (United States); Mahoney, Ryan; Norris, Barry L.; Watkins, Daniel J. [Technical Division, Fermilab, P.O. Box 500, Batavia, IL 60510 (United States); McCluskey, Elaine G. [LBNE Project, Fermilab, P.O. Box 500, Batavia, IL 60510 (United States); Stewart, James [Physics Department, Brookhaven National Laboratory, P.O. Box 5000, Uptown, NY 11973 (United States)

2014-01-29

We report on the design, fabrication, performance and commissioning of the first membrane cryostat to be used for scientific application. The Long Baseline Neutrino Experiment (LBNE) has designed and fabricated a membrane cryostat prototype in collaboration with IHI Corporation (IHI). Original goals of the prototype are: to demonstrate the membrane cryostat technology in terms of thermal performance, feasibility for liquid argon, and leak tightness; to demonstrate that we can remove all the impurities from the vessel and achieve the purity requirements in a membrane cryostat without evacuation and using only a controlled gaseous argon purge; to demonstrate that we can achieve and maintain the purity requirements of the liquid argon during filling, purification, and maintenance mode using mole sieve and copper filters from the Liquid Argon Purity Demonstrator (LAPD) R and D project. The purity requirements of a large liquid argon detector such as LBNE are contaminants below 200 parts per trillion oxygen equivalent. This paper gives the requirements, design, construction, and performance of the LBNE membrane cryostat prototype, with experience and results important to the development of the LBNE detector.

A Secure Web Application Providing Public Access to High-Performance Data Intensive Scientific Resources - ScalaBLAST Web Application

International Nuclear Information System (INIS)

Curtis, Darren S.; Peterson, Elena S.; Oehmen, Chris S.

2008-01-01

This work presents the ScalaBLAST Web Application (SWA), a web based application implemented using the PHP script language, MySQL DBMS, and Apache web server under a GNU/Linux platform. SWA is an application built as part of the Data Intensive Computer for Complex Biological Systems (DICCBS) project at the Pacific Northwest National Laboratory (PNNL). SWA delivers accelerated throughput of bioinformatics analysis via high-performance computing through a convenient, easy-to-use web interface. This approach greatly enhances emerging fields of study in biology such as ontology-based homology, and multiple whole genome comparisons which, in the absence of a tool like SWA, require a heroic effort to overcome the computational bottleneck associated with genome analysis. The current version of SWA includes a user account management system, a web based user interface, and a backend process that generates the files necessary for the Internet scientific community to submit a ScalaBLAST parallel processing job on a dedicated cluster

Comparison of Identify-Friend-Foe and Blue-Force Tracking Decision Support for Combat Identification (Comparaison des Systemes d’aide a la Decision Identification ami ou Ennemi et Suivi des Forces Bleues pour l’Identification au Combat)

Science.gov (United States)

2011-02-01

In the context of the CID task, sensitivity refers to subjects’ psychological discrimination between friends and foes, or their ability to...G. A. (1956). The magical number seven, plus or minus two: Some limits on our capacity for processing information. Psychological Review, 63, 81-97...Wiley. 21. Macmillan, N. A., & Creelman , C. D. (1991). Detection theory: A user’s guide. Cambridge, UK: Cambridge University Press. DRDC Toronto

Scientific Technological Report 2002

International Nuclear Information System (INIS)

Gayoso C, C.; Cuya G, T.; Robles N, A.; Prado C, A.

2003-07-01

This annual scientific-technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2002. This report includes 58 papers divided in 10 subject matters: physics and nuclear chemistry, nuclear engineering, materials, industrial applications, biological applications, medical applications, environmental applications, protection and radiological safety, nuclear safety, and management aspects

Scientific Services on the Cloud

Science.gov (United States)

Chapman, David; Joshi, Karuna P.; Yesha, Yelena; Halem, Milt; Yesha, Yaacov; Nguyen, Phuong

Scientific Computing was one of the first every applications for parallel and distributed computation. To this date, scientific applications remain some of the most compute intensive, and have inspired creation of petaflop compute infrastructure such as the Oak Ridge Jaguar and Los Alamos RoadRunner. Large dedicated hardware infrastructure has become both a blessing and a curse to the scientific community. Scientists are interested in cloud computing for much the same reason as businesses and other professionals. The hardware is provided, maintained, and administrated by a third party. Software abstraction and virtualization provide reliability, and fault tolerance. Graduated fees allow for multi-scale prototyping and execution. Cloud computing resources are only a few clicks away, and by far the easiest high performance distributed platform to gain access to. There may still be dedicated infrastructure for ultra-scale science, but the cloud can easily play a major part of the scientific computing initiative.

Testosterone replacement therapy and the heart: friend, foe or bystander?

Science.gov (United States)

Lopez, David S; Canfield, Steven; Wang, Run

2016-12-01

The role of testosterone therapy (TTh) in cardiovascular disease (CVD) outcomes is still controversial, and it seems will remain inconclusive for the moment. An extensive body of literature has investigated the association of endogenous testosterone and use of TTh with CVD events including several meta-analyses. In some instances, a number of studies reported beneficial effects of TTh on CVD events and in other instances the body of literature reported detrimental effects or no effects at all. Yet, no review article has scrutinized this body of literature using the magnitude of associations and statistical significance reported from this relationship. We critically reviewed the previous and emerging body of literature that investigated the association of endogenous testosterone and use of TTh with CVD events (only fatal and nonfatal). These studies were divided into three groups, "beneficial (friendly use)", "detrimental (foe)" and "no effects at all (bystander)", based on their magnitude of associations and statistical significance from original research studies and meta-analyses of epidemiological studies and of randomized controlled trials (RCT's). In this review article, the studies reporting a significant association of high levels of testosterone with a reduced risk of CVD events in original prospective studies and meta-analyses of cross-sectional and prospective studies seems to be more consistent. However, the number of meta-analyses of RCT's does not provide a clear picture after we divided it into the beneficial, detrimental or no effects all groups using their magnitudes of association and statistical significance. From this review, we suggest that we need a study or number of studies that have the adequate power, epidemiological, and clinical data to provide a definitive conclusion on whether the effect of TTh on the natural history of CVD is real or not.

Scientific workflows as productivity tools for drug discovery.

Science.gov (United States)

Shon, John; Ohkawa, Hitomi; Hammer, Juergen

2008-05-01

Large pharmaceutical companies annually invest tens to hundreds of millions of US dollars in research informatics to support their early drug discovery processes. Traditionally, most of these investments are designed to increase the efficiency of drug discovery. The introduction of do-it-yourself scientific workflow platforms has enabled research informatics organizations to shift their efforts toward scientific innovation, ultimately resulting in a possible increase in return on their investments. Unlike the handling of most scientific data and application integration approaches, researchers apply scientific workflows to in silico experimentation and exploration, leading to scientific discoveries that lie beyond automation and integration. This review highlights some key requirements for scientific workflow environments in the pharmaceutical industry that are necessary for increasing research productivity. Examples of the application of scientific workflows in research and a summary of recent platform advances are also provided.

2003 Scientific Technological Report

International Nuclear Information System (INIS)

Prado Cuba, A.; Gayoso Caballero, C.; Robles Nique, A.; Olivera Lescano, P.

2004-08-01

This annual scientific-technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2003. This report includes 54 papers divided in 9 subject matters: physics and nuclear chemistry, nuclear engineering, materials science, radiochemistry, industrial applications, medical applications, environmental applications, protection and radiological safety, and management aspects

Scientific word, Version 1.0

Directory of Open Access Journals (Sweden)

Semen Köksal

1993-01-01

Full Text Available Scientific Word is the first fully integrated mathematical word processor in the Windows 3.1 environment, which uses the TEX typesetting language for output. It runs as a Microsoft Windows application program and has two-way interface to TEX. The Scientific Word is an object-oriented WYSIWYG word processor for virtually all users who need typesetting scientific books, manuals and papers. It includes automatic equation numbering, spell checking, and LATEX and DVI previewer.

Accelerating scientific discovery : 2007 annual report.

Energy Technology Data Exchange (ETDEWEB)

Beckman, P.; Dave, P.; Drugan, C.

2008-11-14

As a gateway for scientific discovery, the Argonne Leadership Computing Facility (ALCF) works hand in hand with the world's best computational scientists to advance research in a diverse span of scientific domains, ranging from chemistry, applied mathematics, and materials science to engineering physics and life sciences. Sponsored by the U.S. Department of Energy's (DOE) Office of Science, researchers are using the IBM Blue Gene/L supercomputer at the ALCF to study and explore key scientific problems that underlie important challenges facing our society. For instance, a research team at the University of California-San Diego/ SDSC is studying the molecular basis of Parkinson's disease. The researchers plan to use the knowledge they gain to discover new drugs to treat the disease and to identify risk factors for other diseases that are equally prevalent. Likewise, scientists from Pratt & Whitney are using the Blue Gene to understand the complex processes within aircraft engines. Expanding our understanding of jet engine combustors is the secret to improved fuel efficiency and reduced emissions. Lessons learned from the scientific simulations of jet engine combustors have already led Pratt & Whitney to newer designs with unprecedented reductions in emissions, noise, and cost of ownership. ALCF staff members provide in-depth expertise and assistance to those using the Blue Gene/L and optimizing user applications. Both the Catalyst and Applications Performance Engineering and Data Analytics (APEDA) teams support the users projects. In addition to working with scientists running experiments on the Blue Gene/L, we have become a nexus for the broader global community. In partnership with the Mathematics and Computer Science Division at Argonne National Laboratory, we have created an environment where the world's most challenging computational science problems can be addressed. Our expertise in high-end scientific computing enables us to provide

The application of cloud computing to scientific workflows: a study of cost and performance.

Science.gov (United States)

Berriman, G Bruce; Deelman, Ewa; Juve, Gideon; Rynge, Mats; Vöckler, Jens-S

2013-01-28

The current model of transferring data from data centres to desktops for analysis will soon be rendered impractical by the accelerating growth in the volume of science datasets. Processing will instead often take place on high-performance servers co-located with data. Evaluations of how new technologies such as cloud computing would support such a new distributed computing model are urgently needed. Cloud computing is a new way of purchasing computing and storage resources on demand through virtualization technologies. We report here the results of investigations of the applicability of commercial cloud computing to scientific computing, with an emphasis on astronomy, including investigations of what types of applications can be run cheaply and efficiently on the cloud, and an example of an application well suited to the cloud: processing a large dataset to create a new science product.

Advanced I/O for large-scale scientific applications

International Nuclear Information System (INIS)

Klasky, Scott; Schwan, Karsten; Oldfield, Ron A.; Lofstead, Gerald F. II

2010-01-01

As scientific simulations scale to use petascale machines and beyond, the data volumes generated pose a dual problem. First, with increasing machine sizes, the careful tuning of IO routines becomes more and more important to keep the time spent in IO acceptable. It is not uncommon, for instance, to have 20% of an application's runtime spent performing IO in a 'tuned' system. Careful management of the IO routines can move that to 5% or even less in some cases. Second, the data volumes are so large, on the order of 10s to 100s of TB, that trying to discover the scientifically valid contributions requires assistance at runtime to both organize and annotate the data. Waiting for offline processing is not feasible due both to the impact on the IO system and the time required. To reduce this load and improve the ability of scientists to use the large amounts of data being produced, new techniques for data management are required. First, there is a need for techniques for efficient movement of data from the compute space to storage. These techniques should understand the underlying system infrastructure and adapt to changing system conditions. Technologies include aggregation networks, data staging nodes for a closer parity to the IO subsystem, and autonomic IO routines that can detect system bottlenecks and choose different approaches, such as splitting the output into multiple targets, staggering output processes. Such methods must be end-to-end, meaning that even with properly managed asynchronous techniques, it is still essential to properly manage the later synchronous interaction with the storage system to maintain acceptable performance. Second, for the data being generated, annotations and other metadata must be incorporated to help the scientist understand output data for the simulation run as a whole, to select data and data features without concern for what files or other storage technologies were employed. All of these features should be attained while

Fringe order error in multifrequency fringe projection phase unwrapping: reason and correction.

Science.gov (United States)

Zhang, Chunwei; Zhao, Hong; Zhang, Lu

2015-11-10

A multifrequency fringe projection phase unwrapping algorithm (MFPPUA) is important to fringe projection profilometry, especially when a discontinuous object is measured. However, a fringe order error (FOE) may occur when MFPPUA is adopted. An FOE will result in error to the unwrapped phase. Although this kind of phase error does not spread, it brings error to the eventual 3D measurement results. Therefore, an FOE or its adverse influence should be obviated. In this paper, reasons for the occurrence of an FOE are theoretically analyzed and experimentally explored. Methods to correct the phase error caused by an FOE are proposed. Experimental results demonstrate that the proposed methods are valid in eliminating the adverse influence of an FOE.

Scientific applications and numerical algorithms on the midas multiprocessor system

International Nuclear Information System (INIS)

Logan, D.; Maples, C.

1986-01-01

The MIDAS multiprocessor system is a multi-level, hierarchial structure designed at the Advanced Computer Architecture Laboratory of the University of California's Lawrence Berkeley Laboratory. A two-stage, 11-processor system has been operational for over a year and is currently undergoing expansion. It has been employed to investigate the performance of different methods of decomposing various problems and algorithms into a multiprocessor environment. The results of such tests on a variety of applications such as scientific data analysis, Monte Carlo calculations, and image processing, are discussed. Often such decompositions involve investigating the parallel structure of fundamental algorithms. Several basic algorithms dealing with random number generation, matrix diagonalization, fast Fourier transforms, and finite element methods in solving partial differential equations are also discussed. The performance and projected extensibilities of these decompositions on the MIDAS system are reported

Developing Scientific Thinking Methods and Applications in Islamic Education

Science.gov (United States)

Al-Sharaf, Adel

2013-01-01

This article traces the early and medieval Islamic scholarship to the development of critical and scientific thinking and how they contributed to the development of an Islamic theory of epistemology and scientific thinking education. The article elucidates how the Qur'an and the Sunna of Prophet Muhammad have also contributed to the…

Iron and thiols as two major players in carcinogenesis: friends or foes?

Science.gov (United States)

Toyokuni, Shinya

2014-01-01

Iron is the most abundant metal in the human body and mainly works as a cofactor for proteins such as hemoglobin and various enzymes. No independent life forms on earth can survive without iron. However, excess iron is intimately associated with carcinogenesis by increasing oxidative stress via its catalytic activity to generate hydroxyl radicals. Biomolecules with redox-active sulfhydryl function(s) (thiol compounds) are necessary for the maintenance of mildly reductive cellular environments to counteract oxidative stress, and for the execution of redox reactions for metabolism and detoxification. Involvement of glutathione S-transferase and thioredoxin has long attracted the attention of cancer researchers. Here, I update recent findings on the involvement of iron and thiol compounds during carcinogenesis and in cancer cells. It is now recognized that the cystine/glutamate transporter (antiporter) is intimately associated with ferroptosis, an iron-dependent, non-apoptotic form of cell death, observed in cancer cells, and also with cancer stem cells; the former with transporter blockage but the latter with its stabilization. Excess iron in the presence of oxygen appears the most common known mutagen. Ironically, the persistent activation of antioxidant systems via genetic alterations in Nrf2 and Keap1 also contributes to carcinogenesis. Therefore, it is difficult to conclude the role of iron and thiol compounds as friends or foes, which depends on the quantity/distribution and induction/flexibility, respectively. Avoiding further mutation would be the most helpful strategy for cancer prevention, and myriad of efforts are being made to sort out the weaknesses of cancer cells.

Brazilian academic search filter: application to the scientific literature on physical activity.

Science.gov (United States)

Sanz-Valero, Javier; Ferreira, Marcos Santos; Castiel, Luis David; Wanden-Berghe, Carmina; Guilam, Maria Cristina Rodrigues

2010-10-01

To develop a search filter in order to retrieve scientific publications on physical activity from Brazilian academic institutions. The academic search filter consisted of the descriptor "exercise" associated through the term AND, to the names of the respective academic institutions, which were connected by the term OR. The MEDLINE search was performed with PubMed on 11/16/2008. The institutions were selected according to the classification from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for interuniversity agreements. A total of 407 references were retrieved, corresponding to about 0.9% of all articles about physical activity and 0.5% of the Brazilian academic publications indexed in MEDLINE on the search date. When compared with the manual search undertaken, the search filter (descriptor + institutional filter) showed a sensitivity of 99% and a specificity of 100%. The institutional search filter showed high sensitivity and specificity, and is applicable to other areas of knowledge in health sciences. It is desirable that every Brazilian academic institution establish its "standard name/brand" in order to efficiently retrieve their scientific literature.

1999 scientific evaluation at the CEA

International Nuclear Information System (INIS)

1999-01-01

This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members

Scientific computer simulation review

International Nuclear Information System (INIS)

Kaizer, Joshua S.; Heller, A. Kevin; Oberkampf, William L.

2015-01-01

Before the results of a scientific computer simulation are used for any purpose, it should be determined if those results can be trusted. Answering that question of trust is the domain of scientific computer simulation review. There is limited literature that focuses on simulation review, and most is specific to the review of a particular type of simulation. This work is intended to provide a foundation for a common understanding of simulation review. This is accomplished through three contributions. First, scientific computer simulation review is formally defined. This definition identifies the scope of simulation review and provides the boundaries of the review process. Second, maturity assessment theory is developed. This development clarifies the concepts of maturity criteria, maturity assessment sets, and maturity assessment frameworks, which are essential for performing simulation review. Finally, simulation review is described as the application of a maturity assessment framework. This is illustrated through evaluating a simulation review performed by the U.S. Nuclear Regulatory Commission. In making these contributions, this work provides a means for a more objective assessment of a simulation’s trustworthiness and takes the next step in establishing scientific computer simulation review as its own field. - Highlights: • We define scientific computer simulation review. • We develop maturity assessment theory. • We formally define a maturity assessment framework. • We describe simulation review as the application of a maturity framework. • We provide an example of a simulation review using a maturity framework

Biomedical ontologies: toward scientific debate.

Science.gov (United States)

Maojo, V; Crespo, J; García-Remesal, M; de la Iglesia, D; Perez-Rey, D; Kulikowski, C

2011-01-01

Biomedical ontologies have been very successful in structuring knowledge for many different applications, receiving widespread praise for their utility and potential. Yet, the role of computational ontologies in scientific research, as opposed to knowledge management applications, has not been extensively discussed. We aim to stimulate further discussion on the advantages and challenges presented by biomedical ontologies from a scientific perspective. We review various aspects of biomedical ontologies going beyond their practical successes, and focus on some key scientific questions in two ways. First, we analyze and discuss current approaches to improve biomedical ontologies that are based largely on classical, Aristotelian ontological models of reality. Second, we raise various open questions about biomedical ontologies that require further research, analyzing in more detail those related to visual reasoning and spatial ontologies. We outline significant scientific issues that biomedical ontologies should consider, beyond current efforts of building practical consensus between them. For spatial ontologies, we suggest an approach for building "morphospatial" taxonomies, as an example that could stimulate research on fundamental open issues for biomedical ontologies. Analysis of a large number of problems with biomedical ontologies suggests that the field is very much open to alternative interpretations of current work, and in need of scientific debate and discussion that can lead to new ideas and research directions.

[Friend or Foe in the Pocket? - The Role of the Individual, Peergroup and Parents for (dys)functional Mobile Phone Use].

Science.gov (United States)

Knop, Karin; Hefner, Dorothée

2018-02-01

Friend or Foe in the Pocket? - The Role of the Individual, Peergroup and Parents for (dys)functional Mobile Phone Use In order to provide consultative support to parents as well as to children and young people, background knowledge regarding the motives of mobile phone use, functions of usage, comprehension of the attraction of this all-round medium also as knowledge about potential hazards are essential. This study offers empirical results about potentials and risks. The peergroup plays an important role for riskful and problematic mobile phone involvement. Parents function as a role model and the explicit parental mediation practices and their impact on the child are in focus. Data was acquired from a quota-sample survey with 500 children between the age of 8 and 14 years and one of their parents, qualitative interviews (20 children and their parents) and eight peergroup-discussions (52 participants). The present paper illuminates the above mentioned aspects and derives implications for guidance practice.

Mapping the research on scientific collaboration

Institute of Scientific and Technical Information of China (English)

HOU Jianhua; CHEN Chaomei; YAN Jianxin

2010-01-01

The aim of this paper was to identify the trends and hot topics in the study of scientific collaboration via scientometric analysis.Information visualization and knowledge domain visualization techniques were adopted to determine how the study of scientific collaboration has evolved.A total of 1,455 articles on scientific cooperation published between 1993 and 2007 were retrieved from the SCI,SSCI and A&HCI databases with a topic search of scientific collaboration or scientific cooperation for the analysis.By using CiteSpace,the knowledge bases,research foci,and research fronts in the field of scientific collaboration were studied.The results indicated that research fronts and research foci are highly consistent in terms of the concept,origin,measurement,and theory of scientific collaboration.It also revealed that research fronts included scientific collaboration networks,international scientific collaboration,social network analysis and techniques,and applications of bibliometrical indicators,webmetrics,and health care related areas.

C Versus Fortran-77 for Scientific Programming

Directory of Open Access Journals (Sweden)

Tom MacDonald

1992-01-01

Full Text Available The predominant programming language for numeric and scientific applications is Fortran-77 and supercomputers are primarily used to run large-scale numeric and scientific applications. Standard C* is not widely used for numerical and scientific programming, yet Standard C provides many desirable linguistic features not present in Fortran-77. Furthermore, the existence of a standard library and preprocessor eliminates the worst portability problems. A comparison of Standard C and Fortran-77 shows several key deficiencies in C that reduce its ability to adequately solve some numerical problems. Some of these problems have already been addressed by the C standard but others remain. Standard C with a few extensions and modifications could be suitable for all numerical applications and could become more popular in supercomputing environments.

File-System Workload on a Scientific Multiprocessor

Science.gov (United States)

Kotz, David; Nieuwejaar, Nils

1995-01-01

Many scientific applications have intense computational and I/O requirements. Although multiprocessors have permitted astounding increases in computational performance, the formidable I/O needs of these applications cannot be met by current multiprocessors a their I/O subsystems. To prevent I/O subsystems from forever bottlenecking multiprocessors and limiting the range of feasible applications, new I/O subsystems must be designed. The successful design of computer systems (both hardware and software) depends on a thorough understanding of their intended use. A system designer optimizes the policies and mechanisms for the cases expected to most common in the user's workload. In the case of multiprocessor file systems, however, designers have been forced to build file systems based only on speculation about how they would be used, extrapolating from file-system characterizations of general-purpose workloads on uniprocessor and distributed systems or scientific workloads on vector supercomputers (see sidebar on related work). To help these system designers, in June 1993 we began the Charisma Project, so named because the project sought to characterize 1/0 in scientific multiprocessor applications from a variety of production parallel computing platforms and sites. The Charisma project is unique in recording individual read and write requests-in live, multiprogramming, parallel workloads (rather than from selected or nonparallel applications). In this article, we present the first results from the project: a characterization of the file-system workload an iPSC/860 multiprocessor running production, parallel scientific applications at NASA's Ames Research Center.

Statistics and analysis of scientific data

CERN Document Server

Bonamente, Massimiliano

2013-01-01

Statistics and Analysis of Scientific Data covers the foundations of probability theory and statistics, and a number of numerical and analytical methods that are essential for the present-day analyst of scientific data. Topics covered include probability theory, distribution functions of statistics, fits to two-dimensional datasheets and parameter estimation, Monte Carlo methods and Markov chains. Equal attention is paid to the theory and its practical application, and results from classic experiments in various fields are used to illustrate the importance of statistics in the analysis of scientific data. The main pedagogical method is a theory-then-application approach, where emphasis is placed first on a sound understanding of the underlying theory of a topic, which becomes the basis for an efficient and proactive use of the material for practical applications. The level is appropriate for undergraduates and beginning graduate students, and as a reference for the experienced researcher. Basic calculus is us...

Mono or 3D video production for scientific dissemination of nuclear energy applications

International Nuclear Information System (INIS)

Freitas, Victor Goncalves G.; Mol, Antonio Carlos A.; Biermann, Bruna; Jorge, Carlos Alexandre F.; Araujo, Tawein

2011-01-01

This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

Mono or 3D video production for scientific dissemination of nuclear energy applications

Energy Technology Data Exchange (ETDEWEB)

Freitas, Victor Goncalves G.; Mol, Antonio Carlos A.; Biermann, Bruna; Jorge, Carlos Alexandre F., E-mail: mol@ien.gov.b, E-mail: vgoncalves@ien.gov.b, E-mail: calexandre@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Araujo, Tawein [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola de Belas Artes; Legey, Ana Paula [Universidade Gama Filho (UGF), Rio de Janeiro, RJ (Brazil)

2011-07-01

This work presents results of educational videos development, mono or stereo, for scientific dissemination of nuclear energy applications. Nuclear energy span through many important applications for the society, ranging from electrical power generation to nuclear medicine, among others. Thus, the purpose is to disseminate this information for the general public and specially for students. Educational videos consist in a good approach for this purpose, due to the involvement of the public they provide, more than simply text or oral exposition, or even static images presentation. Stereo videos result in even more involvement of the public, besides immersion, the later due to the realism 3D views provide. The video developed in this work deals with explanations of electrical power generation, including nuclear reactor operation, shows the percentage of nuclear source as power generation all over the world, and explains also nuclear energy application in medicine. It is expected all these characteristics provided by the use of video or virtual reality techniques will achieve the purpose of disseminating such important information, regarding the benefits of nuclear energy to the society. (author)

XVIS: Visualization for the Extreme-Scale Scientific-Computation Ecosystem Final Scientific/Technical Report

Energy Technology Data Exchange (ETDEWEB)

Geveci, Berk [Kitware, Inc., Clifton Park, NY (United States); Maynard, Robert [Kitware, Inc., Clifton Park, NY (United States)

2017-10-27

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. The XVis project brought together collaborators from predominant DOE projects for visualization on accelerators and combining their respective features into a new visualization toolkit called VTK-m.

Using Cloud-Computing Applications to Support Collaborative Scientific Inquiry: Examining Pre-Service Teachers' Perceived Barriers to Integration

Science.gov (United States)

Donna, Joel D.; Miller, Brant G.

2013-01-01

Technology plays a crucial role in facilitating collaboration within the scientific community. Cloud-computing applications, such as Google Drive, can be used to model such collaboration and support inquiry within the secondary science classroom. Little is known about pre-service teachers' beliefs related to the envisioned use of collaborative,…

Communication about scientific uncertainty in environmental nanoparticle research - a comparison of scientific literature and mass media

Science.gov (United States)

Heidmann, Ilona; Milde, Jutta

2014-05-01

The research about the fate and behavior of engineered nanoparticles in the environment is despite its wide applications still in the early stages. 'There is a high level of scientific uncertainty in nanoparticle research' is often stated in the scientific community. Knowledge about these uncertainties might be of interest to other scientists, experts and laymen. But how could these uncertainties be characterized and are they communicated within the scientific literature and the mass media? To answer these questions, the current state of scientific knowledge about scientific uncertainty through the example of environmental nanoparticle research was characterized and the communication of these uncertainties within the scientific literature is compared with its media coverage in the field of nanotechnologies. The scientific uncertainty within the field of environmental fate of nanoparticles is by method uncertainties and a general lack of data concerning the fate and effects of nanoparticles and their mechanisms in the environment, and by the uncertain transferability of results to the environmental system. In the scientific literature, scientific uncertainties, their sources, and consequences are mentioned with different foci and to a different extent. As expected, the authors in research papers focus on the certainty of specific results within their specific research question, whereas in review papers, the uncertainties due to a general lack of data are emphasized and the sources and consequences are discussed in a broader environmental context. In the mass media, nanotechnology is often framed as rather certain and positive aspects and benefits are emphasized. Although reporting about a new technology, only in one-third of the reports scientific uncertainties are mentioned. Scientific uncertainties are most often mentioned together with risk and they arise primarily from unknown harmful effects to human health. Environmental issues itself are seldom mentioned

Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.

Science.gov (United States)

Fox, Caroline S; Hall, Jennifer L; Arnett, Donna K; Ashley, Euan A; Delles, Christian; Engler, Mary B; Freeman, Mason W; Johnson, Julie A; Lanfear, David E; Liggett, Stephen B; Lusis, Aldons J; Loscalzo, Joseph; MacRae, Calum A; Musunuru, Kiran; Newby, L Kristin; O'Donnell, Christopher J; Rich, Stephen S; Terzic, Andre

2015-05-12

The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful translation that directly affects disease prevention and clinical care. The purpose of this scientific statement is to address the gap between genetic discoveries and their practical application to cardiovascular clinical care. In brief, this scientific statement assesses the current timeline for effective translation of basic discoveries to clinical advances, highlighting past successes. Current discoveries in the area of genetics and genomics are covered next, followed by future expectations, tools, and competencies for achieving the goal of improving clinical care. © 2015 American Heart Association, Inc.

Fractional-order devices

CERN Document Server

Biswas, Karabi; Caponetto, Riccardo; Mendes Lopes, António; Tenreiro Machado, José António

2017-01-01

This book focuses on two specific areas related to fractional order systems – the realization of physical devices characterized by non-integer order impedance, usually called fractional-order elements (FOEs); and the characterization of vegetable tissues via electrical impedance spectroscopy (EIS) – and provides readers with new tools for designing new types of integrated circuits. The majority of the book addresses FOEs. The interest in these topics is related to the need to produce “analogue” electronic devices characterized by non-integer order impedance, and to the characterization of natural phenomena, which are systems with memory or aftereffects and for which the fractional-order calculus tool is the ideal choice for analysis. FOEs represent the building blocks for designing and realizing analogue integrated electronic circuits, which the authors believe hold the potential for a wealth of mass-market applications. The freedom to choose either an integer- or non-integer-order analogue integrator...

Monitoring of IaaS and scientific applications on the Cloud using the Elasticsearch ecosystem

Science.gov (United States)

Bagnasco, S.; Berzano, D.; Guarise, A.; Lusso, S.; Masera, M.; Vallero, S.

2015-05-01

The private Cloud at the Torino INFN computing centre offers IaaS services to different scientific computing applications. The infrastructure is managed with the OpenNebula cloud controller. The main stakeholders of the facility are a grid Tier-2 site for the ALICE collaboration at LHC, an interactive analysis facility for the same experiment and a grid Tier-2 site for the BES-III collaboration, plus an increasing number of other small tenants. Besides keeping track of the usage, the automation of dynamic allocation of resources to tenants requires detailed monitoring and accounting of the resource usage. As a first investigation towards this, we set up a monitoring system to inspect the site activities both in terms of IaaS and applications running on the hosted virtual instances. For this purpose we used the Elasticsearch, Logstash and Kibana stack. In the current implementation, the heterogeneous accounting information is fed to different MySQL databases and sent to Elasticsearch via a custom Logstash plugin. For the IaaS metering, we developed sensors for the OpenNebula API. The IaaS level information gathered through the API is sent to the MySQL database through an ad-hoc developed RESTful web service, which is also used for other accounting purposes. Concerning the application level, we used the Root plugin TProofMonSenderSQL to collect accounting data from the interactive analysis facility. The BES-III virtual instances used to be monitored with Zabbix, as a proof of concept we also retrieve the information contained in the Zabbix database. Each of these three cases is indexed separately in Elasticsearch. We are now starting to consider dismissing the intermediate level provided by the SQL database and evaluating a NoSQL option as a unique central database for all the monitoring information. We setup a set of Kibana dashboards with pre-defined queries in order to monitor the relevant information in each case. In this way we have achieved a uniform monitoring

Research initiatives for plug-and-play scientific computing

International Nuclear Information System (INIS)

McInnes, Lois Curfman; Dahlgren, Tamara; Nieplocha, Jarek; Bernholdt, David; Allan, Ben; Armstrong, Rob; Chavarria, Daniel; Elwasif, Wael; Gorton, Ian; Kenny, Joe; Krishan, Manoj; Malony, Allen; Norris, Boyana; Ray, Jaideep; Shende, Sameer

2007-01-01

This paper introduces three component technology initiatives within the SciDAC Center for Technology for Advanced Scientific Component Software (TASCS) that address ever-increasing productivity challenges in creating, managing, and applying simulation software to scientific discovery. By leveraging the Common Component Architecture (CCA), a new component standard for high-performance scientific computing, these initiatives tackle difficulties at different but related levels in the development of component-based scientific software: (1) deploying applications on massively parallel and heterogeneous architectures, (2) investigating new approaches to the runtime enforcement of behavioral semantics, and (3) developing tools to facilitate dynamic composition, substitution, and reconfiguration of component implementations and parameters, so that application scientists can explore tradeoffs among factors such as accuracy, reliability, and performance

Imidacloprid poisoning: a modern foe

OpenAIRE

Raminderpal Singh Sibia; Amith Kumar S; Sandipkumar Radheshyam Dhoot

2014-01-01

Imidacloprid is a relatively new insecticide in the chloronicotinyl nitroguanidine class. Imidacloprid has a wide variety of uses; it is used on cotton and vegetable crops, turf grass and ornamental plant products, in indoor and outdoor cockroach control products and in termite control products. Imidacloprid acts as a competitive inhibitor at nicotinic acetylcholine receptors in the nervous system resulting in impairment of normal nerve function. Scientific literature on human imidacloprid po...

Final Report for 'Center for Technology for Advanced Scientific Component Software'

International Nuclear Information System (INIS)

Shasharina, Svetlana

2010-01-01

The goal of the Center for Technology for Advanced Scientific Component Software is to fundamentally changing the way scientific software is developed and used by bringing component-based software development technologies to high-performance scientific and engineering computing. The role of Tech-X work in TASCS project is to provide an outreach to accelerator physics and fusion applications by introducing TASCS tools into applications, testing tools in the applications and modifying the tools to be more usable.

National nuclear scientific program

International Nuclear Information System (INIS)

Plecas, I.; Matausek, M.V.; Neskovic, N.

2001-01-01

National scientific program of the Vinca Institute Nuclear Reactors And Radioactive Waste comprises research and development in the following fields: application of energy of nuclear fission, application of neutron beams, analyses of nuclear safety and radiation protection. In the first phase preparatory activities, conceptual design and design of certain processes and facilities should be accomplished. In the second phase realization of the projects is expected. (author)

The Realist Paradigm Of Energy Diplomacy In The Russian Scientific Tradition And Its Practical Applicability

Directory of Open Access Journals (Sweden)

R. О. Reinhardt

2018-01-01

Full Text Available Nowadays energy diplomacy tends to be one of most relevant and important fields of applied research in International Relations. It is characterized by an interdisciplinary approach being an intersection of political and economic theory, international law, energetics, theory of diplomacy, as well as other fields. Still, numerous research works in the given area both in Russia and abroad are characterized by a number of controversies, such as absence of a common theoretical, methodological basis and conventional terminology, as well as lack of consistency in the choice of scientific paradigms, which leads to divergence of research results and hinders the comparability of the latter. Along with that, in terms of scientific policy it is worth mentioning the absence of a common scientific space in the above field of research, which tends to be shaped by national research cultures and traditions. Throughout the 2000-2010s representatives of the MGIMO scientific school have accumulated experience in dealing with problems of energy diplomacy. However, most of the existing works do not specify the selected political theory paradigms, such as, for instance, realism, liberalism or constructivism. With no intention to conduct a comparative analysis of the aforementioned concepts, the authors of the article outline the key theoretical findings of political realism as the most suitable paradigm for explaining, analyzing and eventually forecasting the recent trends and phenomena given the current geopolitical and economical juncture. They prove the applicability of the proposed model to the OPEC case study and demonstrate its potential practical usefulness for policy-makers in foreign affairs and international energy relations.

Scientific visualization uncertainty, multifield, biomedical, and scalable visualization

CERN Document Server

Chen, Min; Johnson, Christopher; Kaufman, Arie; Hagen, Hans

2014-01-01

Based on the seminar that took place in Dagstuhl, Germany in June 2011, this contributed volume studies the four important topics within the scientific visualization field: uncertainty visualization, multifield visualization, biomedical visualization and scalable visualization. • Uncertainty visualization deals with uncertain data from simulations or sampled data, uncertainty due to the mathematical processes operating on the data, and uncertainty in the visual representation, • Multifield visualization addresses the need to depict multiple data at individual locations and the combination of multiple datasets, • Biomedical is a vast field with select subtopics addressed from scanning methodologies to structural applications to biological applications, • Scalability in scientific visualization is critical as data grows and computational devices range from hand-held mobile devices to exascale computational platforms. Scientific Visualization will be useful to practitioners of scientific visualization, ...

Community Intelligence in Knowledge Curation: An Application to Managing Scientific Nomenclature

OpenAIRE

Dai, Lin; Xu, Chao; Tian, Ming; Sang, Jian; Zou, Dong; Li, Ang; Liu, Guocheng; Chen, Fei; Wu, Jiayan; Xiao, Jingfa; Wang, Xumin; Yu, Jun; Zhang, Zhang

2013-01-01

Harnessing community intelligence in knowledge curation bears significant promise in dealing with communication and education in the flood of scientific knowledge. As knowledge is accumulated at ever-faster rates, scientific nomenclature, a particular kind of knowledge, is concurrently generated in all kinds of fields. Since nomenclature is a system of terms used to name things in a particular discipline, accurate translation of scientific nomenclature in different languages is of critical im...

Future Translational Applications From the Contemporary Genomics Era: A Scientific Statement From the American Heart Association

OpenAIRE

Fox, Caroline S.; Hall, Jennifer L.; Arnett, Donna K.; Ashley, Euan A.; Delles, Christian; Engler, Mary B.; Freeman, Mason W.; Johnson, Julie A.; Lanfear, David E.; Liggett, Stephen B.; Lusis, Aldons J.; Loscalzo, Joseph; MacRae, Calum A.; Musunuru, Kiran; Newby, L. Kristin

2015-01-01

The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful translation that directly affects disease prevention and clinical care. The purpose of this scientific statement is to address the gap between genetic discoveries and their practical application to cardi...

The graphics future in scientific applications-trends and developments in computer graphics

CERN Document Server

Enderle, G

1982-01-01

Computer graphics methods and tools are being used to a great extent in scientific research. The future development in this area will be influenced both by new hardware developments and by software advances. On the hardware sector, the development of the raster technology will lead to the increased use of colour workstations with more local processing power. Colour hardcopy devices for creating plots, slides, or movies will be available at a lower price than today. The first real 3D-workstations will appear on the marketplace. One of the main activities on the software sector is the standardization of computer graphics systems, graphical files, and device interfaces. This will lead to more portable graphical application programs and to a common base for computer graphics education.

Rapid development of scalable scientific software using a process oriented approach

DEFF Research Database (Denmark)

Friborg, Rune Møllegaard; Vinter, Brian

2011-01-01

Scientific applications are often not written with multiprocessing, cluster computing or grid computing in mind. This paper suggests using Python and PyCSP to structure scientific software through Communicating Sequential Processes. Three scientific applications are used to demonstrate the features...... of PyCSP and how networks of processes may easily be mapped into a visual representation for better understanding of the process workflow. We show that for many sequential solutions, the difficulty in implementing a parallel application is removed. The use of standard multi-threading mechanisms...

HPCToolkit: performance tools for scientific computing

Energy Technology Data Exchange (ETDEWEB)

Tallent, N; Mellor-Crummey, J; Adhianto, L; Fagan, M; Krentel, M [Department of Computer Science, Rice University, Houston, TX 77005 (United States)

2008-07-15

As part of the U.S. Department of Energy's Scientific Discovery through Advanced Computing (SciDAC) program, science teams are tackling problems that require simulation and modeling on petascale computers. As part of activities associated with the SciDAC Center for Scalable Application Development Software (CScADS) and the Performance Engineering Research Institute (PERI), Rice University is building software tools for performance analysis of scientific applications on the leadership-class platforms. In this poster abstract, we briefly describe the HPCToolkit performance tools and how they can be used to pinpoint bottlenecks in SPMD and multi-threaded parallel codes. We demonstrate HPCToolkit's utility by applying it to two SciDAC applications: the S3D code for simulation of turbulent combustion and the MFDn code for ab initio calculations of microscopic structure of nuclei.

HPCToolkit: performance tools for scientific computing

International Nuclear Information System (INIS)

Tallent, N; Mellor-Crummey, J; Adhianto, L; Fagan, M; Krentel, M

2008-01-01

As part of the U.S. Department of Energy's Scientific Discovery through Advanced Computing (SciDAC) program, science teams are tackling problems that require simulation and modeling on petascale computers. As part of activities associated with the SciDAC Center for Scalable Application Development Software (CScADS) and the Performance Engineering Research Institute (PERI), Rice University is building software tools for performance analysis of scientific applications on the leadership-class platforms. In this poster abstract, we briefly describe the HPCToolkit performance tools and how they can be used to pinpoint bottlenecks in SPMD and multi-threaded parallel codes. We demonstrate HPCToolkit's utility by applying it to two SciDAC applications: the S3D code for simulation of turbulent combustion and the MFDn code for ab initio calculations of microscopic structure of nuclei

Managing Scientific Software Complexity with Bocca and CCA

Directory of Open Access Journals (Sweden)

Benjamin A. Allan

2008-01-01

Full Text Available In high-performance scientific software development, the emphasis is often on short time to first solution. Even when the development of new components mostly reuses existing components or libraries and only small amounts of new code must be created, dealing with the component glue code and software build processes to obtain complete applications is still tedious and error-prone. Component-based software meant to reduce complexity at the application level increases complexity to the extent that the user must learn and remember the interfaces and conventions of the component model itself. To address these needs, we introduce Bocca, the first tool to enable application developers to perform rapid component prototyping while maintaining robust software-engineering practices suitable to HPC environments. Bocca provides project management and a comprehensive build environment for creating and managing applications composed of Common Component Architecture components. Of critical importance for high-performance computing (HPC applications, Bocca is designed to operate in a language-agnostic way, simultaneously handling components written in any of the languages commonly used in scientific applications: C, C++, Fortran, Python and Java. Bocca automates the tasks related to the component glue code, freeing the user to focus on the scientific aspects of the application. Bocca embraces the philosophy pioneered by Ruby on Rails for web applications: start with something that works, and evolve it to the user's purpose.

A model of "integrated scientific method" and its application for the analysis of instruction

Science.gov (United States)

Rusbult, Craig Francis

A model of 'integrated scientific method' (ISM) was constructed as a framework for describing the process of science in terms of activities (formulating a research problem, and inventing and evaluating actions--such as selecting and inventing theories, evaluating theories, designing experiments, and doing experiments--intended to solve the problem) and evaluation criteria (empirical, conceptual, and cultural-personal). Instead of trying to define the scientific method, ISM is intended to serve as a flexible framework that--by varying the characteristics of its components, their integrated relationships, and their relative importance can be used to describe a variety of scientific methods, and a variety of perspectives about what constitutes an accurate portrayal of scientific methods. This framework is outlined visually and verbally, followed by an elaboration of the framework and my own views about science, and an evaluation of whether ISM can serve as a relatively neutral framework for describing a wide range of science practices and science interpretations. ISM was used to analyze an innovative, guided inquiry classroom (taught by Susan Johnson, using Genetics Construction Kit software) in which students do simulated scientific research by solving classical genetics problems that require effect-to-cause reasoning and theory revision. The immediate goal of analysis was to examine the 'science experiences' of students, to determine how the 'structure of instruction' provides opportunities for these experiences. Another goal was to test and improve the descriptive and analytical utility of ISM. In developing ISM, a major objective was to make ISM educationally useful. A concluding discussion includes controversies about "the nature of science" and how to teach it, how instruction can expand opportunities for student experience, and how goal-oriented intentional learning (using ISM might improve the learning, retention, and transfer of thinking skills. Potential

Scientific impact: opportunity and necessity.

Science.gov (United States)

Cohen, Marlene Z; Alexander, Gregory L; Wyman, Jean F; Fahrenwald, Nancy L; Porock, Davina; Wurzbach, Mary E; Rawl, Susan M; Conn, Vicki S

2010-08-01

Recent National Institutes of Health changes have focused attention on the potential scientific impact of research projects. Research with the excellent potential to change subsequent science or health care practice may have high scientific impact. Only rigorous studies that address highly significant problems can generate change. Studies with high impact may stimulate new research approaches by changing understanding of a phenomenon, informing theory development, or creating new research methods that allow a field of science to move forward. Research with high impact can transition health care to more effective and efficient approaches. Studies with high impact may propel new policy developments. Research with high scientific impact typically has both immediate and sustained influence on the field of study. The article includes ideas to articulate potential scientific impact in grant applications as well as possible dissemination strategies to enlarge the impact of completed projects.

75 FR 39683 - Clean Water Act Section 312(b): Notice Seeking Stakeholder Input on Petition and Other Request To...

Science.gov (United States)

2010-07-12

... the Earth (FOE) and another separate request for rulemaking under section 312 of the Clean Water Act... performance standards for vessel sewage treatment devices under the CWA. The rulemaking petition from FOE also... Petition On April 28, 2009, pursuant to the Administrative Procedure Act, Friends of the Earth (FOE...

Adherence to Scientific Method while Advancing Exposure Science

Science.gov (United States)

Paul Lioy was simultaneously a staunch adherent to the scientific method and an innovator of new ways to conduct science, particularly related to human exposure. Current challenges to science and the application of the scientific method are presented as they relate the approaches...

Tools for Reproducibility and Extensibility in Scientific Research

CERN Multimedia

CERN. Geneva

2018-01-01

Open inquiry through reproducing results is fundamental to the scientific process. Contemporary research relies on software engineering pipelines to collect, process, and analyze data. The open source projects within Project Jupyter facilitate these objectives by bringing software engineering within the context of scientific communication. We will highlight specific projects that are computational building blocks for scientific communication, starting with the Jupyter Notebook. We will also explore applications of projects that build off of the Notebook such as Binder, JupyterHub, and repo2docker. We will discuss how these projects can individually and jointly improve reproducibility in scientific communication. Finally, we will demonstrate applications of Jupyter software that allow researchers to build upon the code of other scientists, both to extend their work and the work of others.    There will be a follow-up demo session in the afternoon, hosted by iML. Details can be foun...

Scientific and Technological Report 2004

International Nuclear Information System (INIS)

Prado Cuba, Antonio; Robles Nique, Anita; Solis Veliz, Jose; Rodriguez R, Juan

2005-08-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2004. This report includes 48 papers divided in 6 subject matters, such as: materials science, nuclear engineering, industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects

78 FR 27260 - Southern California Edison, San Onofre Nuclear Generating Station, Units 2 and 3 Request for Action

Science.gov (United States)

2013-05-09

... (NRC) is giving notice that by petition dated June 18, 2012, Friends of the Earth (FOE, the petitioner... 12, 2013 (ADAMS Accession No. ML13116A265), FOE requested that Mitsubishi Heavy Industries' Report... this petition within a reasonable time. Further, FOE submitted on April 4, 2013, a cover letter and...

Radiation protection. Scientific fundamentals, legal regulations, practical applications. Compendium

International Nuclear Information System (INIS)

Buchert, Guido; Gay, Juergen; Kirchner, Gerald; Michel, Rolf; Niggemann, Guenter; Schumann, Joerg; Wust, Peter; Jaehnert, Susanne; Strilek, Ralf; Martini, Ekkehard

2011-06-01

The compendium on radiation protection, scientific fundamentals, legal regulations and practical applications includes contributions to the following issues: (1) Effects and risk of ionizing radiation: fundamentals on effects and risk of ionizing radiation, news in radiation biology, advantages and disadvantages of screening investigations; (2) trends and legal regulations concerning radiation protection: development of European and national radiation protection laws, new regulations concerning X-rays, culture and ethics of radiation protection; (3) dosimetry and radiation measuring techniques: personal scanning using GHz radiation, new ''dose characteristics'' in practice, measuring techniques for the nuclear danger prevention and emergency hazard control; (4) radiation exposure in medicine: radiation exposure of modern medical techniques, heavy ion radiotherapy, deterministic and stochastic risks of the high-conformal photon radiotherapy, STEMO project - mobile CT for apoplectic stroke patients; (5) radiation exposure in technology: legal control of high-level radioactive sources, technical and public safety using enclosed radioactive sources for materials testing, radiation exposure in aviation, radon in Bavaria, NPP Fukushima-Daiichi - a status report; (6) radiation exposure in nuclear engineering: The Chernobyl accident - historical experiences or sustaining problem? European standards for radioactive waste disposal, radioactive material disposal in Germany risk assessment of ionizing and non-ionizing radiation (7) Case studies.

Automatic recognition of conceptualization zones in scientific articles and two life science applications.

Science.gov (United States)

Liakata, Maria; Saha, Shyamasree; Dobnik, Simon; Batchelor, Colin; Rebholz-Schuhmann, Dietrich

2012-04-01

Scholarly biomedical publications report on the findings of a research investigation. Scientists use a well-established discourse structure to relate their work to the state of the art, express their own motivation and hypotheses and report on their methods, results and conclusions. In previous work, we have proposed ways to explicitly annotate the structure of scientific investigations in scholarly publications. Here we present the means to facilitate automatic access to the scientific discourse of articles by automating the recognition of 11 categories at the sentence level, which we call Core Scientific Concepts (CoreSCs). These include: Hypothesis, Motivation, Goal, Object, Background, Method, Experiment, Model, Observation, Result and Conclusion. CoreSCs provide the structure and context to all statements and relations within an article and their automatic recognition can greatly facilitate biomedical information extraction by characterizing the different types of facts, hypotheses and evidence available in a scientific publication. We have trained and compared machine learning classifiers (support vector machines and conditional random fields) on a corpus of 265 full articles in biochemistry and chemistry to automatically recognize CoreSCs. We have evaluated our automatic classifications against a manually annotated gold standard, and have achieved promising accuracies with 'Experiment', 'Background' and 'Model' being the categories with the highest F1-scores (76%, 62% and 53%, respectively). We have analysed the task of CoreSC annotation both from a sentence classification as well as sequence labelling perspective and we present a detailed feature evaluation. The most discriminative features are local sentence features such as unigrams, bigrams and grammatical dependencies while features encoding the document structure, such as section headings, also play an important role for some of the categories. We discuss the usefulness of automatically generated Core

Scientific Advances with Aspergillus Species that Are Used for Food and Biotech Applications.

Science.gov (United States)

Biesebeke, Rob Te; Record, Erik

2008-01-01

Yeast and filamentous fungi have been used for centuries in diverse biotechnological processes. Fungal fermentation technology is traditionally used in relation to food production, such as for bread, beer, cheese, sake and soy sauce. Last century, the industrial application of yeast and filamentous fungi expanded rapidly, with excellent examples such as purified enzymes and secondary metabolites (e.g. antibiotics), which are used in a wide range of food as well as non-food industries. Research on protein and/or metabolite secretion by fungal species has focused on identifying bottlenecks in (post-) transcriptional regulation of protein production, metabolic rerouting, morphology and the transit of proteins through the secretion pathway. In past years, genome sequencing of some fungi (e.g. Aspergillus oryzae, Aspergillus niger) has been completed. The available genome sequences have enabled identification of genes and functionally important regions of the genome. This has directed research to focus on a post-genomics era in which transcriptomics, proteomics and metabolomics methodologies will help to explore the scientific relevance and industrial application of fungal genome sequences.

77 FR 39682 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2012-07-05

... invite comments on the question of whether instruments of equivalent scientific value, for the purposes... components with increased reliability, performance, reduction of cost, and improved safety, using technology... reliability investigations on the nanometer scale, to identify porosity, fracture surface features, fiber...

5th International Conference on High Performance Scientific Computing

CERN Document Server

Hoang, Xuan; Rannacher, Rolf; Schlöder, Johannes

2014-01-01

This proceedings volume gathers a selection of papers presented at the Fifth International Conference on High Performance Scientific Computing, which took place in Hanoi on March 5-9, 2012. The conference was organized by the Institute of Mathematics of the Vietnam Academy of Science and Technology (VAST), the Interdisciplinary Center for Scientific Computing (IWR) of Heidelberg University, Ho Chi Minh City University of Technology, and the Vietnam Institute for Advanced Study in Mathematics. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and practical applications. Subjects covered include mathematical modeling; numerical simulation; methods for optimization and control; parallel computing; software development; and applications of scientific computing in physics, mechanics and biomechanics, material science, hydrology, chemistry, biology, biotechnology, medicine, sports, psychology, transport, logistics, com...

3rd International Conference on High Performance Scientific Computing

CERN Document Server

Kostina, Ekaterina; Phu, Hoang; Rannacher, Rolf

2008-01-01

This proceedings volume contains a selection of papers presented at the Third International Conference on High Performance Scientific Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg, and its International PhD Program ``Complex Processes: Modeling, Simulation and Optimization'', and Ho Chi Minh City University of Technology. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and control, parallel computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site loca...

6th International Conference on High Performance Scientific Computing

CERN Document Server

Phu, Hoang; Rannacher, Rolf; Schlöder, Johannes

2017-01-01

This proceedings volume highlights a selection of papers presented at the Sixth International Conference on High Performance Scientific Computing, which took place in Hanoi, Vietnam on March 16-20, 2015. The conference was jointly organized by the Heidelberg Institute of Theoretical Studies (HITS), the Institute of Mathematics of the Vietnam Academy of Science and Technology (VAST), the Interdisciplinary Center for Scientific Computing (IWR) at Heidelberg University, and the Vietnam Institute for Advanced Study in Mathematics, Ministry of Education The contributions cover a broad, interdisciplinary spectrum of scientific computing and showcase recent advances in theory, methods, and practical applications. Subjects covered numerical simulation, methods for optimization and control, parallel computing, and software development, as well as the applications of scientific computing in physics, mechanics, biomechanics and robotics, material science, hydrology, biotechnology, medicine, transport, scheduling, and in...

FAA Air Traffic Control Operations Concepts. Volume 4. TAAS (Terminal Advanced Automation System) Terminal Controllers

Science.gov (United States)

1988-07-29

manually under controller comiand. 40.3.7.1.2.1.1.2-19 b. Ordering - In manual ordering , the 780 controller shall have the capability to put o new FOE...7.1.2.1.1.2-09 a. Posting - This orgonization of FOEs shall 780 be provided at the option of the controller. 40.3.7.1.2.1.1.2-19 b. Ordering - In manual ... ordering , the 780 controller shall have the capability to put o new FOE in the appropriate place in a list and to move FOEs with respect to one another

Scientific evaluation at the CEA; Evaluation scientifique au CEA

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-11-01

This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1998. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 5 parts dealing successively with: part 1 - the CEA, a public research organization (civil nuclear research, technology research and transfers, defence activities); the scientific and technical evaluation at the CEA (general framework, evaluation of the IPSN and DAM); part 2 - the scientific and technical councils (directions of fuel cycle, of nuclear reactors, and of advanced technologies); part 3 - the scientific councils (directions of matter and of life sciences); the nuclear protection and safety institute; the direction of military applications; part 4 - the corresponding members of the evaluation; part 5 - the list of scientific and technical councils and members. (J.S.)

The emergence of scientific management in America

Directory of Open Access Journals (Sweden)

Sorin-George Toma

2014-05-01

Full Text Available A scientific approach to management was initiated for the first time in America in the late 19th century. Scientific management arose mainly from the need to increase efficiency in America, but other key factors were the spread of big businesses and the expanding application of science in industry. The aims of our paper are to present the emergence of scientific management in America and to emphasize the contribution of some of the most representatives American authors to its development. The methodological approach is literature review. Our paper shows that scientific management was essentially an American achievement that provided useful lessons for the whole human society.

Scientific and Technological Report 2006

International Nuclear Information System (INIS)

Prado Cuba, Antonio; Robles Nique, Anita; Solis Veliz, Jose; Osores Rebaza, Jose

2007-08-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2006. This report includes 54 papers divided in 7 subject matters, such as: physics and chemistry, materials science, nuclear engineering, industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects. (APC)

Scientific and Technological Report 2005

International Nuclear Information System (INIS)

Prado Cuba, Antonio; Robles Nique, Anita; Rodriguez R, Juan; Solis Veliz, Jose

2006-07-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2005. This report includes 38 papers divided in 7 subject matters, such as: physics and chemistry, materials science, nuclear engineering, industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects

76 FR 52314 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2011-08-22

... invite comments on the question of whether instruments of equivalent scientific value, for the purposes...: Projekt Messtechnik, Germany. Intended Use: The SPSx will be used to monitor the water-solid interaction... instrument monitors water-solid interactions by taking gravimetric measurement of samples continuously using...

Impact of research investment on scientific productivity of junior researchers.

Science.gov (United States)

Farrokhyar, Forough; Bianco, Daniela; Dao, Dyda; Ghert, Michelle; Andruszkiewicz, Nicole; Sussman, Jonathan; Ginsberg, Jeffrey S

2016-12-01

There is a demand for providing evidence on the effectiveness of research investments on the promotion of novice researchers' scientific productivity and production of research with new initiatives and innovations. We used a mixed method approach to evaluate the funding effect of the New Investigator Fund (NIF) by comparing scientific productivity between award recipients and non-recipients. We reviewed NIF grant applications submitted from 2004 to 2013. Scientific productivity was assessed by confirming the publication of the NIF-submitted application. Online databases were searched, independently and in duplicate, to locate the publications. Applicants' perceptions and experiences were collected through a short survey and categorized into specified themes. Multivariable logistic regression was performed. Odds ratios (OR) with 95 % confidence intervals (CI) are reported. Of 296 applicants, 163 (55 %) were awarded. Gender, affiliation, and field of expertise did not affect funding decisions. More physicians with graduate education (32.0 %) and applicants with a doctorate degree (21.5 %) were awarded than applicants without postgraduate education (9.8 %). Basic science research (28.8 %), randomized controlled trials (24.5 %), and feasibility/pilot trials (13.3 %) were awarded more than observational designs (p   scientific productivity and professional growth of novice investigators and production of research with new initiatives and innovations. Further efforts are recommended to enhance the support of small grant funding programs.

On the influence of solar activity on the mid-latitude sporadic E layer

Science.gov (United States)

Pezzopane, Michael; Pignalberi, Alessio; Pietrella, Marco

2015-09-01

To investigate the influence of solar cycle variability on the sporadic E layer (Es), hourly measurements of the critical frequency of the Es ordinary mode of propagation, foEs, and of the blanketing frequency of the Es layer, fbEs, recorded from January 1976 to December 2009 at the Rome (Italy) ionospheric station (41.8° N, 12.5° E), were examined. The results are: (1) a high positive correlation between the F10.7 solar index and foEs as well as between F10.7 and fbEs, both for the whole data set and for each solar cycle separately, the correlation between F10.7 and fbEs being much higher than the one between F10.7 and foEs; (2) a decreasing long-term trend of the F10.7, foEs and fbEs time series, with foEs decreasing more rapidly than F10.7 and fbEs; (3) clear and statistically significant peaks at 11 years in the foEs and fbEs time series, inferred from Lomb-Scargle periodograms.

High-performance scientific computing in the cloud

Science.gov (United States)

Jorissen, Kevin; Vila, Fernando; Rehr, John

2011-03-01

Cloud computing has the potential to open up high-performance computational science to a much broader class of researchers, owing to its ability to provide on-demand, virtualized computational resources. However, before such approaches can become commonplace, user-friendly tools must be developed that hide the unfamiliar cloud environment and streamline the management of cloud resources for many scientific applications. We have recently shown that high-performance cloud computing is feasible for parallelized x-ray spectroscopy calculations. We now present benchmark results for a wider selection of scientific applications focusing on electronic structure and spectroscopic simulation software in condensed matter physics. These applications are driven by an improved portable interface that can manage virtual clusters and run various applications in the cloud. We also describe a next generation of cluster tools, aimed at improved performance and a more robust cluster deployment. Supported by NSF grant OCI-1048052.

Communication Requirements and Interconnect Optimization forHigh-End Scientific Applications

Energy Technology Data Exchange (ETDEWEB)

Kamil, Shoaib; Oliker, Leonid; Pinar, Ali; Shalf, John

2007-11-12

The path towards realizing peta-scale computing isincreasingly dependent on building supercomputers with unprecedentednumbers of processors. To prevent the interconnect from dominating theoverall cost of these ultra-scale systems, there is a critical need forhigh-performance network solutions whose costs scale linearly with systemsize. This work makes several unique contributions towards attaining thatgoal. First, we conduct one of the broadest studies to date of high-endapplication communication requirements, whose computational methodsinclude: finite-difference, lattice-bolzmann, particle in cell, sparselinear algebra, particle mesh ewald, and FFT-based solvers. Toefficiently collect this data, we use the IPM (Integrated PerformanceMonitoring) profiling layer to gather detailed messaging statistics withminimal impact to code performance. Using the derived communicationcharacterizations, we next present fit-trees interconnects, a novelapproach for designing network infrastructure at a fraction of thecomponent cost of traditional fat-tree solutions. Finally, we propose theHybrid Flexibly Assignable Switch Topology (HFAST) infrastructure, whichuses both passive (circuit) and active (packet) commodity switchcomponents to dynamically reconfigure interconnects to suit thetopological requirements of scientific applications. Overall ourexploration leads to a promising directions for practically addressingthe interconnect requirements of future peta-scale systems.

Toward fostering the scientific and technological literacy establishment of the 'Central Scientific and Technological Museum-Institute' and nuclear development

International Nuclear Information System (INIS)

Murata, Takashi

1999-01-01

The public in general does not necessarily have enough knowledge for the reasonable decision making in the application of scientific and technological development even in the ear of the Information Society. However strongly the necessity of the consensus in the scientific policy like nuclear R and D is required, it is impossible to attain the goal, unless the scientific literacy of the general public is. In order to improve it the role of the scientific museum as a social educational facility is very important. In this respect, there still remains vast room to improve in the Japanese museum system and its activities. The concept of the 'Central Scientific and Technological Museum-Institute', which also operates very small-sized reactor for the educational use, is developed in this paper. (author)

Standardization of Color Palettes for Scientific Visualization

Energy Technology Data Exchange (ETDEWEB)

Kulesza, Joel A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Spencer, Joshua Bradly [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sood, Avneet [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-06-12

The purpose of this white paper is to demonstrate the importance of color palette choice in scientific visualizations and to promote an effort to convene an interdisciplinary team of researchers to study and recommend color palettes based on intended application(s) and audience(s).

[Investigation methodology and application on scientific and technological personnel of traditional Chinese medical resources based on data from Chinese scientific research paper].

Science.gov (United States)

Li, Hai-yan; Li, Yuan-hai; Yang, Yang; Liu, Fang-zhou; Wang, Jing; Tian, Ye; Yang, Ce; Liu, Yang; Li, Meng; Sun Li-ying

2015-12-01

The aim of this study is to identify the present status of the scientific and technological personnel in the field of traditional Chinese medicine (TCM) resource science. Based on the data from Chinese scientific research paper, an investigation regarding the number of the personnel, the distribution, their output of paper, their scientific research teams, high-yield authors and high-cited authors was conducted. The study covers seven subfields of traditional Chinese medicine identification, quality standard, Chinese medicine cultivation, harvest processing of TCM, market development and resource protection and resource management, as well as 82 widely used Chinese medicine species, such as Ginseng and Radix Astragali. One hundred and fifteen domain authority experts were selected based on the data of high-yield authors and high-cited authors. The database system platform "Skilled Scientific and Technological Personnel in the field of Traditional Chinese Medicine Resource Science-Chinese papers" was established. This platform successfully provided the retrieval result of the personnel, output of paper, and their core research team by input the study field, year, and Chinese medicine species. The investigation provides basic data of scientific and technological personnel in the field of traditional Chinese medicine resource science for administrative agencies and also evidence for the selection of scientific and technological personnel and construction of scientific research teams.

Customizable scientific web portal for fusion research

International Nuclear Information System (INIS)

Abla, G.; Kim, E.N.; Schissel, D.P.; Flanagan, S.M.

2010-01-01

Web browsers have become a major application interface for participating in scientific experiments such as those in magnetic fusion. The recent advances in web technologies motivated the deployment of interactive web applications with rich features. In the scientific world, web applications have been deployed in portal environments. When used in a scientific research environment, such as fusion experiments, web portals can present diverse sources of information in a unified interface. However, the design and development of a scientific web portal has its own challenges. One such challenge is that a web portal needs to be fast and interactive despite the high volume of information and number of tools it presents. Another challenge is that the visual output of the web portal must not be overwhelming to the end users, despite the high volume of data generated by fusion experiments. Therefore, the applications and information should be customizable depending on the needs of end users. In order to meet these challenges, the design and implementation of a web portal needs to support high interactivity and user customization. A web portal has been designed to support the experimental activities of DIII-D researchers worldwide by providing multiple services, such as real-time experiment status monitoring, diagnostic data access and interactive data visualization. The web portal also supports interactive collaborations by providing a collaborative logbook, shared visualization and online instant messaging services. The portal's design utilizes the multi-tier software architecture and has been implemented utilizing web 2.0 technologies, such as AJAX, Django, and Memcached, to develop a highly interactive and customizable user interface. It offers a customizable interface with personalized page layouts and list of services, which allows users to create a unique, personalized working environment to fit their own needs and interests. This paper describes the software

Customizable scientific web portal for fusion research

Energy Technology Data Exchange (ETDEWEB)

Abla, G., E-mail: abla@fusion.gat.co [General Atomics, P.O. Box 85608, San Diego, CA (United States); Kim, E.N.; Schissel, D.P.; Flanagan, S.M. [General Atomics, P.O. Box 85608, San Diego, CA (United States)

2010-07-15

Web browsers have become a major application interface for participating in scientific experiments such as those in magnetic fusion. The recent advances in web technologies motivated the deployment of interactive web applications with rich features. In the scientific world, web applications have been deployed in portal environments. When used in a scientific research environment, such as fusion experiments, web portals can present diverse sources of information in a unified interface. However, the design and development of a scientific web portal has its own challenges. One such challenge is that a web portal needs to be fast and interactive despite the high volume of information and number of tools it presents. Another challenge is that the visual output of the web portal must not be overwhelming to the end users, despite the high volume of data generated by fusion experiments. Therefore, the applications and information should be customizable depending on the needs of end users. In order to meet these challenges, the design and implementation of a web portal needs to support high interactivity and user customization. A web portal has been designed to support the experimental activities of DIII-D researchers worldwide by providing multiple services, such as real-time experiment status monitoring, diagnostic data access and interactive data visualization. The web portal also supports interactive collaborations by providing a collaborative logbook, shared visualization and online instant messaging services. The portal's design utilizes the multi-tier software architecture and has been implemented utilizing web 2.0 technologies, such as AJAX, Django, and Memcached, to develop a highly interactive and customizable user interface. It offers a customizable interface with personalized page layouts and list of services, which allows users to create a unique, personalized working environment to fit their own needs and interests. This paper describes the software

Is risk analysis scientific?

Science.gov (United States)

Hansson, Sven Ove; Aven, Terje

2014-07-01

This article discusses to what extent risk analysis is scientific in view of a set of commonly used definitions and criteria. We consider scientific knowledge to be characterized by its subject matter, its success in developing the best available knowledge in its fields of study, and the epistemic norms and values that guide scientific investigations. We proceed to assess the field of risk analysis according to these criteria. For this purpose, we use a model for risk analysis in which science is used as a base for decision making on risks, which covers the five elements evidence, knowledge base, broad risk evaluation, managerial review and judgment, and the decision; and that relates these elements to the domains experts and decisionmakers, and to the domains fact-based or value-based. We conclude that risk analysis is a scientific field of study, when understood as consisting primarily of (i) knowledge about risk-related phenomena, processes, events, etc., and (ii) concepts, theories, frameworks, approaches, principles, methods and models to understand, assess, characterize, communicate, and manage risk, in general and for specific applications (the instrumental part). © 2014 Society for Risk Analysis.

Unravelling Starlight

Science.gov (United States)

Becker, Barbara J.

2017-03-01

1. Introduction; 2. '… the astronomer … must come to the chemist'; 3. The young observer; 4. 'A sudden impulse …'; 5. The riddle of the nebulae; 6. Moving in the inner circle; 7. Stellar motion along the line of sight; 8. A new telescope; 9. Solar observatories; 10. An able assistant; 11. Photographing the solar corona; 12. A scientific lady; 13. Foes and allies; 14. The new astronomy; 15. 'One true mistress'; 16. Conclusion; Appendix; Index.

Reform of reserve requirements for nuclear decommissioning, dismantling and disposal; Reform der Atomrueckstellungen fuer Stilllegung/Rueckbau und Entsorgung

Energy Technology Data Exchange (ETDEWEB)

Meyer, Bettina [Forum Oekologisch-Soziale Marktwirtschaft e.V. (FOeS), Berlin (Germany); Kuechler, Swantje; Wronski, Rupert [Forum Oekologisch-Soziale Marktwirtschaft e.V. (FOeS), Berlin (Germany). Bereich Energiepolitik

2015-07-15

This article reports on the ongoing intense discussion as to whether the financial reserves of nuclear power plant operators are sufficient. It starts out with an overview of the current scientific and political debate. This is followed by a brief analysis of nuclear financial reserves in 2014 and preceding years. The authors then present the reform concept of the Forum Oekologisch-Soziale Marktwirtschaft (FOes) and go on to compare it with concepts from the political realm.

Test Driven Development of Scientific Models

Science.gov (United States)

Clune, Thomas L.

2012-01-01

Test-Driven Development (TDD) is a software development process that promises many advantages for developer productivity and has become widely accepted among professional software engineers. As the name suggests, TDD practitioners alternate between writing short automated tests and producing code that passes those tests. Although this overly simplified description will undoubtedly sound prohibitively burdensome to many uninitiated developers, the advent of powerful unit-testing frameworks greatly reduces the effort required to produce and routinely execute suites of tests. By testimony, many developers find TDD to be addicting after only a few days of exposure, and find it unthinkable to return to previous practices. Of course, scientific/technical software differs from other software categories in a number of important respects, but I nonetheless believe that TDD is quite applicable to the development of such software and has the potential to significantly improve programmer productivity and code quality within the scientific community. After a detailed introduction to TDD, I will present the experience within the Software Systems Support Office (SSSO) in applying the technique to various scientific applications. This discussion will emphasize the various direct and indirect benefits as well as some of the difficulties and limitations of the methodology. I will conclude with a brief description of pFUnit, a unit testing framework I co-developed to support test-driven development of parallel Fortran applications.

The Application of SPSS in Data Process of Medical Scientific Research%SPSS在医学科研数据处理中的应用

Institute of Scientific and Technical Information of China (English)

龙雅玲

2011-01-01

目的结合医院统计工作实际介绍总结SPSS(Statistical Package Social Science,社会科学统计软件包)在医学科研统计分析中的应用.方法援引医学科研常例论述SPSS软件在医学科研中的实际应用操作.结果应用SPSS进行医学科研数据处理,能快速准确地得到统计结果.结论 SPSS操作简单易学,能让临床试验过程中所获得的大量医学数据的处理变得简单轻松起来,为医学科研提供了强有力的支持.%Objectives It introduces and summarizes the application of SPSS in medical scientific research statistic and analysis combing with practical work of hospital statistic . Methods This article quotes medical scientific research cases for expound the practical application operation of SPSS in medical scientific research . Results It rapidly gets correct statistic results by using SPSS for data process of medical scientific research . Conclusions The opetation of SPSS is simple and easy to learn which makes process of a large amount of medical data getting from clinical lab sim pler , providing strong support for medical scientific research .

Mathematical and Scientific Foundations for an Integrative Engineering Curriculum.

Science.gov (United States)

Carr, Robin; And Others

1995-01-01

Describes the Mathematical and Scientific Foundations of Engineering curriculum which emphasizes the mathematical and scientific concepts common to all engineering fields. Scientists and engineers together devised topics and experiments that emphasize the relevance of theory to real-world applications. Presents material efficiently while building…

Scientific and Technological Report 2009

International Nuclear Information System (INIS)

Prado Cuba, Antonio; Santiago Contreras, Julio; Lopez Milla, Alcides; Ramos Trujillo, Bertha

2010-11-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2009. This report includes 46 papers divided in 7 subject matters, such as: physics and chemistry, materials science, nuclear engineering, mining industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects. It also includes annexes. (APC)

Scientific and Technological Report 2008

International Nuclear Information System (INIS)

Prado Cuba, A.; Santiago Contreras, J.; Rojas Tapia, J.; Ramos Trujillo, B.; Vela Mora, M.; Castro Gamero, E.

2010-04-01

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2008. This report includes 60 papers divided in 7 subject matters, such as: physics and chemistry, materials science, nuclear engineering, mining industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects. It also includes annexes. (APC)

Engineering and Scientific Applications: Using MatLab(Registered Trademark) for Data Processing and Visualization

Science.gov (United States)

Sen, Syamal K.; Shaykhian, Gholam Ali

2011-01-01

MatLab(TradeMark)(MATrix LABoratory) is a numerical computation and simulation tool that is used by thousands Scientists and Engineers in many countries. MatLab does purely numerical calculations, which can be used as a glorified calculator or interpreter programming language; its real strength is in matrix manipulations. Computer algebra functionalities are achieved within the MatLab environment using "symbolic" toolbox. This feature is similar to computer algebra programs, provided by Maple or Mathematica to calculate with mathematical equations using symbolic operations. MatLab in its interpreter programming language form (command interface) is similar with well known programming languages such as C/C++, support data structures and cell arrays to define classes in object oriented programming. As such, MatLab is equipped with most of the essential constructs of a higher programming language. MatLab is packaged with an editor and debugging functionality useful to perform analysis of large MatLab programs and find errors. We believe there are many ways to approach real-world problems; prescribed methods to ensure foregoing solutions are incorporated in design and analysis of data processing and visualization can benefit engineers and scientist in gaining wider insight in actual implementation of their perspective experiments. This presentation will focus on data processing and visualizations aspects of engineering and scientific applications. Specifically, it will discuss methods and techniques to perform intermediate-level data processing covering engineering and scientific problems. MatLab programming techniques including reading various data files formats to produce customized publication-quality graphics, importing engineering and/or scientific data, organizing data in tabular format, exporting data to be used by other software programs such as Microsoft Excel, data presentation and visualization will be discussed.

Gamma-delta (γδ) T cells: friend or foe in cancer development?

Science.gov (United States)

Zhao, Yijing; Niu, Chao; Cui, Jiuwei

2018-01-10

γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between the innate and adaptive immune systems, γδ T cells participate in various immune responses during cancer progression. Because of their direct/indirect antitumor cytotoxicity and strong cytokine production ability, the use of γδ T cells in cancer immunotherapy has received a lot of attention over the past decade. Despite the promising potential of γδ T cells, the efficacy of γδ T cell immunotherapy is limited, with an average response ratio of only 21%. In addition, research over the past 2 years has shown that γδ T cells could also promote cancer progression by inhibiting antitumor responses, and enhancing cancer angiogenesis. As a result, γδ T cells have a dual effect and can therefore be considered as being both "friends" and "foes" of cancer. In order to solve the sub-optimal efficiency problem of γδ T cell immunotherapy, we review recent observations regarding the antitumor and protumor activities of major structural and functional subsets of human γδ T cells, describing how these subsets are activated and polarized, and how these events relate to subsequent effects in cancer immunity. A mixture of both antitumor or protumor γδ T cells used in adoptive immunotherapy, coupled with the fact that γδ T cells can be polarized from antitumor cells to protumor cells appear to be the likely reasons for the mild efficacy seen with γδ T cells. The future holds the promise of depleting the specific protumor γδ T cell subgroup before therapy, choosing multi-immunocyte adoptive therapy, modifying the cytokine balance in the cancer microenvironment, and using a combination of γδ T cells adoptive immunotherapy with immune checkpoint inhibitors.

Self-identification and empathy modulate error-related brain activity during the observation of penalty shots between friend and foe

Science.gov (United States)

Ganesh, Shanti; van Schie, Hein T.; De Bruijn, Ellen R. A.; Bekkering, Harold

2009-01-01

The ability to detect and process errors made by others plays an important role is many social contexts. The capacity to process errors is typically found to rely on sites in the medial frontal cortex. However, it remains to be determined whether responses at these sites are driven primarily by action errors themselves or by the affective consequences normally associated with their commission. Using an experimental paradigm that disentangles action errors and the valence of their affective consequences, we demonstrate that sites in the medial frontal cortex (MFC), including the ventral anterior cingulate cortex (vACC) and pre-supplementary motor area (pre-SMA), respond to action errors independent of the valence of their consequences. The strength of this response was negatively correlated with the empathic concern subscale of the Interpersonal Reactivity Index. We also demonstrate a main effect of self-identification by showing that errors committed by friends and foes elicited significantly different BOLD responses in a separate region of the middle anterior cingulate cortex (mACC). These results suggest that the way we look at others plays a critical role in determining patterns of brain activation during error observation. These findings may have important implications for general theories of error processing. PMID:19015079

Computer application in scientific investigations

International Nuclear Information System (INIS)

Govorun, N.N.

1981-01-01

A short review of the computer development and application and software in JINR for the last 15 years is presented. Main trends of studies on computer application in experimental and theoretical investigations are enumerated: software of computers and their systems, software of data processing systems, designing automatic and automized systems for measuring track detectors images, development of technique of carrying out experiments on computer line, packets of applied computer codes and specialized systems. The development of the on line technique is successfully used in investigations of nuclear processes at relativistic energies. The new trend is the development of television methods of data output and its computer recording [ru

Towards Monitoring-as-a-service for Scientific Computing Cloud applications using the ElasticSearch ecosystem

CERN Document Server

Bagnasco, S; Guarise, A; Lusso, S; Masera, M; Vallero, S

2015-01-01

The INFN computing centre in Torino hosts a private Cloud, which is managed with the OpenNebula cloud controller. The infrastructure offers Infrastructure-as-a-Service (IaaS) and Platform-as-a-Service (PaaS) services to different scientific computing applications. The main stakeholders of the facility are a grid Tier-2 site for the ALICE collaboration at LHC, an interactive analysis facility for the same experiment and a grid Tier-2 site for the BESIII collaboration, plus an increasing number of other small tenants. The dynamic allocation of resources to tenants is partially automated. This feature requires detailed monitoring and accounting of the resource usage. We set up a monitoring framework to inspect the site activities both in terms of IaaS and applications running on the hosted virtual instances. For this purpose we used the ElasticSearch, Logstash and Kibana (ELK) stack. The infrastructure relies on a MySQL database back-end for data preservation and to ensure flexibility to choose a different monit...

Analysis of student’s scientific attitude behaviour change effects blended learning supported by I-spring Suite 8 application

Science.gov (United States)

Budiharti, Rini; Waras, N. S.

2018-05-01

This article aims to describe the student’s scientific attitude behaviour change as treatment effect of Blended Learning supported by I-Spring Suite 8 application on the material balance and the rotational dynamics. Blended Learning models is learning strategy that integrate between face-to-face learning and online learning by combination of various media. Blended Learning model supported I-Spring Suite 8 media setting can direct learning becomes interactive. Students are guided to actively interact with the media as well as with other students to discuss getting the concept by the phenomena or facts presented. The scientific attitude is a natural attitude of students in the learning process. In interactive learning, scientific attitude is so needed. The research was conducted using a model Lesson Study which consists of the stages Plan-Do-Check-Act (PDCA) and applied to the subject of learning is students at class XI MIPA 2 of Senior High School 6 Surakarta. The validity of the data used triangulation techniques of observation, interviews and document review. Based on the discussion, it can be concluded that the use of Blended Learning supported media I-Spring Suite 8 is able to give the effect of changes in student behaviour on all dimensions of scientific attitude that is inquisitive, respect the data or fact, critical thinking, discovery and creativity, open minded and cooperation, and perseverance. Display e-learning media supported student worksheet makes the students enthusiastically started earlier, the core until the end of learning

[A study of the occupational stress norm and it' s application for the technical group and scientific research group].

Science.gov (United States)

Yang, Xin-wei; Liu, Ze-jun; Zhao, Pei-qing; Bai, Shao-ying; Pang, Xing-huo; Wang, Zhi-ming; Jin, Tai-yi; Lan, Ya-jia

2006-11-01

A study of the occupational stress norm and it' s application for the technical group and scientific research group. In this study, cross-sectional study method is used, and a synthetic way of sorting and randomized sampling is adopted to deal with research targets(235 scientific research group, 857 technical group). Descriptive statistics for OSI-R scale scores for the technical group and scientific research group were modulated. Scale raw score to T-score conversion tables derived from the OSI-R normative sample for technical group and scientific research group were established. OSI-R profile from for technical group and scientific research group were established. For the ORQ and PSQ scales, scores at or above 70T indicate a strong levels of maladaptive stress and strain. Score in the range of 60T to 69T suggest middle levels of maladaptive stress and strain. Score in the range of 40T to 59T indicate normal levels of stress and strain. Score below 40T indicate a relative absence of occupational stress and strain. For the PRQ scales, score below 30T indicate a significant lack of coping resources. Score in the range of 30T to 39T suggest middle deficits in coping resources. Score in the range of 40T to 59T indicate average coping resources. Scores at or above 60T indicate a strong levels of coping resources. Different intervention measure should be take to reduce the occupational stress so as to improve the work ability.

Lost in Translation: The Gap in Scientific Advancements and Clinical Application

Directory of Open Access Journals (Sweden)

Joseph eFernandez-Moure

2016-06-01

Full Text Available The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside. Born out of the increasing need to facilitate the transfer of scientific knowledge to patients, translational research has emerged. Significant leaps in improving global health such as antibiotics, vaccinations, and cancer therapies have all seen successes under this paradigm yet today it has become increasingly difficult to realize this ideal scenario. As hospital revenue demand increase, and financial support declines, clinician protected research time has been limited. Researchers, likewise, have been forced to abandon time and resource consuming translational research to focus on publication generating work to maintain funding and professional advancement. Compared to the surge in scientific innovation and new fields of science have surged, realization of transformational scientific findings in device development and materials sciences has significantly lagged behind. Herein, we describe: how the current scientific paradigm struggles in the new health-care landscape; the obstacles met by translational researchers; and solutions, both public and private, to overcoming those obstacles. We must rethink the old dogma of academia and reinvent the traditional pathways of research in order to truly impact the health-care arena and ultimately those that matter most: the patient.

Scientific Technological Report 2002; Informe Cientifico Tecnologico 2002

Energy Technology Data Exchange (ETDEWEB)

Gayoso C, C; Cuya G, T; Robles N, A; Prado C, A [eds.

2003-07-01

This annual scientific-technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2002. This report includes 58 papers divided in 10 subject matters: physics and nuclear chemistry, nuclear engineering, materials, industrial applications, biological applications, medical applications, environmental applications, protection and radiological safety, nuclear safety, and management aspects.

A primer on scientific programming with Python

CERN Document Server

Langtangen, Hans Petter

2014-01-01

The book serves as a first introduction to computer programming of scientific applications, using the high-level Python language. The exposition is example and problem-oriented, where the applications are taken from mathematics, numerical calculus, statistics, physics, biology and finance. The book teaches "Matlab-style" and procedural programming as well as object-oriented programming. High school mathematics is a required background and it is advantageous to study classical and numerical one-variable calculus in parallel with reading this book. Besides learning how to program computers, the reader will also learn how to solve mathematical problems, arising in various branches of science and engineering, with the aid of numerical methods and programming. By blending programming, mathematics and scientific applications, the book lays a solid foundation for practicing computational science. From the reviews: Langtangen … does an excellent job of introducing programming as a set of skills in problem solving. ...

A primer on scientific programming with Python

CERN Document Server

Langtangen, Hans Petter

2016-01-01

The book serves as a first introduction to computer programming of scientific applications, using the high-level Python language. The exposition is example and problem-oriented, where the applications are taken from mathematics, numerical calculus, statistics, physics, biology and finance. The book teaches "Matlab-style" and procedural programming as well as object-oriented programming. High school mathematics is a required background and it is advantageous to study classical and numerical one-variable calculus in parallel with reading this book. Besides learning how to program computers, the reader will also learn how to solve mathematical problems, arising in various branches of science and engineering, with the aid of numerical methods and programming. By blending programming, mathematics and scientific applications, the book lays a solid foundation for practicing computational science. From the reviews: Langtangen … does an excellent job of introducing programming as a set of skills in problem solving. ...

OPTIMIZATION OF SCIENTIFIC AND TECHNICAL EXPERTISE OF THE APPLICATIONS FOR STATE SUBSIDIES

Directory of Open Access Journals (Sweden)

S. Yu. Tuzova

2016-01-01

Full Text Available The main aspects of the evaluation of projects for the grant of Federal Target Program «Researches and developments in priority directions of scientific and technological complex of Russia for 2014-2020» is discussed. This subject is very relevant, because the efficiency of scientific and technical expertise is a guarantee of the eff ectiveness of innovative projects management. This is particularly important for the projects, which have significant practical orientation and being competitive in the international scientific and technical level.The purpose of this article is a justification of importance of improvement of technologies of information support of experts. These technologies allow to draw the attention of the expert to a number of discrepancies in the documentation, to quickly process the large volume of information at various scientometric databases, to reduce the manhours of the expert per project and to increase efficiency of scientific and technical expertise.Advantages and disadvantages of the use of machine analysis of keyword and semantic analysis of documents during the scientific and technical expertise have been described. The criteria for peer review as a quality research project; qualifications, work experience, academic achievements of the project implementing team and instrument base; the potential Bidder; financial support of the project. Various criteria for analysis of the project (quality of the research project, qualifications, work experience, academic achievements of the project implementing team and their instrument base, the potential and the project financial support are considered.Conclusions. First, use of modern information technology in scientific and technical expertise allows to expand the information field and an expert to carry out a deeper analysis of projects. Secondly, the stocktaking of the advantages and disadvantages of using machine analysis for keywords and semantic analysis of the documents

Teaching Scientific Communication Skills in Science Studies: Does It Make a Difference?

Science.gov (United States)

Spektor-Levy, Ornit; Eylon, Bat-Sheva; Scherz, Zahava

2009-01-01

This study explores the impact of "Scientific Communication" (SC) skills instruction on students' performances in scientific literacy assessment tasks. We present a general model for skills instruction, characterized by explicit and spiral instruction, integration into content learning, practice in several scientific topics, and application of…

Toward fostering the scientific and technological literacy establishment of the 'Central Scientific and Technological Museum-Institute' and nuclear development

Energy Technology Data Exchange (ETDEWEB)

Murata, Takashi [Graduate School of Energy Sci., Kyoto Univ., Kyoto (Japan)

1999-12-01

The public in general does not necessarily have enough knowledge for the reasonable decision making in the application of scientific and technological development even in the ear of the Information Society. However strongly the necessity of the consensus in the scientific policy like nuclear R and D is required, it is impossible to attain the goal, unless the scientific literacy of the general public is. In order to improve it the role of the scientific museum as a social educational facility is very important. In this respect, there still remains vast room to improve in the Japanese museum system and its activities. The concept of the 'Central Scientific and Technological Museum-Institute', which also operates very small-sized reactor for the educational use, is developed in this paper. (author)

The new carbon forms in the scientific instrumentation

International Nuclear Information System (INIS)

Saniger B, J.M.

1999-01-01

Applications in the development of scientific instrumentation of some of the new forms of carbon are discussed in this work. A short revision is presented of the remaining technical problems of the applications of diamond thin films as active semiconductor elements; heat sinks; X-ray, UV and particle detectors; surface acoustic wave devices, etc. Some advances in the improvement of the surface quality and textural design of diamond films are also presented. On the other hand, the possible implications of carbon nano tubes in scientific instrumentation are also discussed mainly for the development of electronic nano devices. Finally, other promising applications of carbon nano tubes as nano tips for atomic force and scanning tunneling microscopes, as well as nano-host structures for the synthesis of metallic carbide and nitride nano wires are also presented. (Author)

Scientific Programming in Fortran

Directory of Open Access Journals (Sweden)

W. Van Snyder

2007-01-01

Full Text Available The Fortran programming language was designed by John Backus and his colleagues at IBM to reduce the cost of programming scientific applications. IBM delivered the first compiler for its model 704 in 1957. IBM's competitors soon offered incompatible versions. ANSI (ASA at the time developed a standard, largely based on IBM's Fortran IV in 1966. Revisions of the standard were produced in 1977, 1990, 1995 and 2003. Development of a revision, scheduled for 2008, is under way. Unlike most other programming languages, Fortran is periodically revised to keep pace with developments in language and processor design, while revisions largely preserve compatibility with previous versions. Throughout, the focus on scientific programming, and especially on efficient generated programs, has been maintained.

Cray XT4: An Early Evaluation for Petascale Scientific Simulation

International Nuclear Information System (INIS)

Alam, Sadaf R.; Barrett, Richard F.; Fahey, Mark R.; Kuehn, Jeffery A.; Sankaran, Ramanan; Worley, Patrick H.; Larkin, Jeffrey M.

2007-01-01

The scientific simulation capabilities of next generation high-end computing technology will depend on striking a balance among memory, processor, I/O, and local and global network performance across the breadth of the scientific simulation space. The Cray XT4 combines commodity AMD dual core Opteron processor technology with the second generation of Cray's custom communication accelerator in a system design whose balance is claimed to be driven by the demands of scientific simulation. This paper presents an evaluation of the Cray XT4 using microbenchmarks to develop a controlled understanding of individual system components, providing the context for analyzing and comprehending the performance of several petascale-ready applications. Results gathered from several strategic application domains are compared with observations on the previous generation Cray XT3 and other high-end computing systems, demonstrating performance improvements across a wide variety of application benchmark problems.

Predicting future discoveries from current scientific literature.

Science.gov (United States)

Petrič, Ingrid; Cestnik, Bojan

2014-01-01

Knowledge discovery in biomedicine is a time-consuming process starting from the basic research, through preclinical testing, towards possible clinical applications. Crossing of conceptual boundaries is often needed for groundbreaking biomedical research that generates highly inventive discoveries. We demonstrate the ability of a creative literature mining method to advance valuable new discoveries based on rare ideas from existing literature. When emerging ideas from scientific literature are put together as fragments of knowledge in a systematic way, they may lead to original, sometimes surprising, research findings. If enough scientific evidence is already published for the association of such findings, they can be considered as scientific hypotheses. In this chapter, we describe a method for the computer-aided generation of such hypotheses based on the existing scientific literature. Our literature-based discovery of NF-kappaB with its possible connections to autism was recently approved by scientific community, which confirms the ability of our literature mining methodology to accelerate future discoveries based on rare ideas from existing literature.

Towards Monitoring-as-a-service for Scientific Computing Cloud applications using the ElasticSearch ecosystem

Science.gov (United States)

Bagnasco, S.; Berzano, D.; Guarise, A.; Lusso, S.; Masera, M.; Vallero, S.

2015-12-01

The INFN computing centre in Torino hosts a private Cloud, which is managed with the OpenNebula cloud controller. The infrastructure offers Infrastructure-as-a-Service (IaaS) and Platform-as-a-Service (PaaS) services to different scientific computing applications. The main stakeholders of the facility are a grid Tier-2 site for the ALICE collaboration at LHC, an interactive analysis facility for the same experiment and a grid Tier-2 site for the BESIII collaboration, plus an increasing number of other small tenants. The dynamic allocation of resources to tenants is partially automated. This feature requires detailed monitoring and accounting of the resource usage. We set up a monitoring framework to inspect the site activities both in terms of IaaS and applications running on the hosted virtual instances. For this purpose we used the ElasticSearch, Logstash and Kibana (ELK) stack. The infrastructure relies on a MySQL database back-end for data preservation and to ensure flexibility to choose a different monitoring solution if needed. The heterogeneous accounting information is transferred from the database to the ElasticSearch engine via a custom Logstash plugin. Each use-case is indexed separately in ElasticSearch and we setup a set of Kibana dashboards with pre-defined queries in order to monitor the relevant information in each case. For the IaaS metering, we developed sensors for the OpenNebula API. The IaaS level information gathered through the API is sent to the MySQL database through an ad-hoc developed RESTful web service. Moreover, we have developed a billing system for our private Cloud, which relies on the RabbitMQ message queue for asynchronous communication to the database and on the ELK stack for its graphical interface. The Italian Grid accounting framework is also migrating to a similar set-up. Concerning the application level, we used the Root plugin TProofMonSenderSQL to collect accounting data from the interactive analysis facility. The BESIII

Advanced Excel for scientific data analysis

CERN Document Server

De Levie, Robert

2004-01-01

Excel is by far the most widely distributed data analysis software but few users are aware of its full powers. Advanced Excel For Scientific Data Analysis takes off from where most books dealing with scientific applications of Excel end. It focuses on three areas-least squares, Fourier transformation, and digital simulation-and illustrates these with extensive examples, often taken from the literature. It also includes and describes a number of sample macros and functions to facilitate common data analysis tasks. These macros and functions are provided in uncompiled, computer-readable, easily

2003 Scientific Technological Report; Informe Cientifico Tecnologico 2003

Energy Technology Data Exchange (ETDEWEB)

Prado Cuba, A; Gayoso Caballero, C; Robles Nique, A; Olivera Lescano, P [eds.

2004-08-15

This annual scientific-technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2003. This report includes 54 papers divided in 9 subject matters: physics and nuclear chemistry, nuclear engineering, materials science, radiochemistry, industrial applications, medical applications, environmental applications, protection and radiological safety, and management aspects.

Procurement management in scientific research and production project

International Nuclear Information System (INIS)

Wan Yi

2008-01-01

To meet the requirement of development trend of scientific research and production, it is necessary to incorporate the modern procurement management theory in the whole procurement process for the items used in scientific research and production.This paper provided some suggestions to improve the procurement management by introducing the experiences in the application of the modern procurement management methods in the procurement of parts production. (author)

Business and scientific workflows a web service-oriented approach

CERN Document Server

Tan, Wei

2013-01-01

Focuses on how to use web service computing and service-based workflow technologies to develop timely, effective workflows for both business and scientific fields Utilizing web computing and Service-Oriented Architecture (SOA), Business and Scientific Workflows: A Web Service-Oriented Approach focuses on how to design, analyze, and deploy web service-based workflows for both business and scientific applications in many areas of healthcare and biomedicine. It also discusses and presents the recent research and development results. This informative reference features app

Summary of scientific investigations for the Waste Isolation Pilot Plant

International Nuclear Information System (INIS)

Weart, W.D.

1996-01-01

The scientific issues concerning disposal of radioactive wastes in salt formations have received 40 years of attention since the National Academy of Sciences (NAS) first addressed this issue in the mid-50s. For the last 21 years, Sandia National Laboratories (SNL) have directed site specific studies for the Waste Isolation Pilot Plant (WIPP). This paper will focus primarily on the WIPP scientific studies now in their concluding stages, the major scientific controversies regarding the site, and some of the surprises encountered during the course of these scientific investigations. The WIPP project's present understanding of the scientific processes involved continues to support the site as a satisfactory, safe location for the disposal of defense-related transuranic waste and one which will be shown to be in compliance with Environmental Protection Agency (EPA) standards. Compliance will be evaluated by incorporating data from these experiments into Performance Assessment (PA) models developed to describe the physical and chemical processes that could occur at the WIPP during the next 10,000 years under a variety of scenarios. The resulting compliance document is scheduled to be presented to the EPA in October 1996 and all relevant information from scientific studies will be included in this application and the supporting analyses. Studies supporting this compliance application conclude the major period of scientific investigation for the WIPP. Further studies will be of a ''confirmatory'' and monitoring nature

Enhancements to VTK enabling Scientific Visualization in Immersive Environments

Energy Technology Data Exchange (ETDEWEB)

O' Leary, Patrick; Jhaveri, Sankhesh; Chaudhary, Aashish; Sherman, William; Martin, Ken; Lonie, David; Whiting, Eric; Money, James

2017-04-01

Modern scientific, engineering and medical computational sim- ulations, as well as experimental and observational data sens- ing/measuring devices, produce enormous amounts of data. While statistical analysis provides insight into this data, scientific vi- sualization is tactically important for scientific discovery, prod- uct design and data analysis. These benefits are impeded, how- ever, when scientific visualization algorithms are implemented from scratch—a time-consuming and redundant process in im- mersive application development. This process can greatly ben- efit from leveraging the state-of-the-art open-source Visualization Toolkit (VTK) and its community. Over the past two (almost three) decades, integrating VTK with a virtual reality (VR) environment has only been attempted to varying degrees of success. In this pa- per, we demonstrate two new approaches to simplify this amalga- mation of an immersive interface with visualization rendering from VTK. In addition, we cover several enhancements to VTK that pro- vide near real-time updates and efficient interaction. Finally, we demonstrate the combination of VTK with both Vrui and OpenVR immersive environments in example applications.

Measurement of Scientific Productivity in R&D Sector: Changing paradigm.

Science.gov (United States)

Kumar, Abhishek; Srivastava, Alpana; Kumar, R P Jeevan; Tiwari, Rajesh K

2017-01-01

Scientific Productivity is a demand of policy makers for a judicious utilization of massive R&D budget allocated and utilized. A huge mass of intellectual assets is employed, which after investing manpower, infrastructure and lab consumables demand for a major outcome which contributes towards building nation's economy. Scientific productivity was only measured through publications or patents. Patents, earmarked as a strong parameter for innovation generation, where, Word Intellectual Property Organisation generated a data on applications for the top 20 offices for patents, where Australia, Brazil and Canada occupied top 3 positions. India ranked 9th with the total patent applications rising from 39762 (2010) to 42854 (2014) i.e. 15%, whereas, it contributes around 2% Patents (innovative productivity) on global scale. Many studies have come forward interestingly within scientific and academic domains in the form of measurement of scientific performance, however, development of productivity indicators and calculation of Scientific Productivity (SP) as a holistic evaluation system is a significant demand. SP, a herculean task is envisaged for productivity analysis and would submit significant factors towards fabricating an effective measurement engine in a holistic manner viable for an individual and organization, being supplementary to each other. This review projects the significance of performance measurement system in R&D through identification and standardization of key parameters. It also includes emphasis on inclusion of standardized parameters, effective for performance measurement which is applicable for scientists, technical staff as well as lab as a facility. This review aims at providing an insight to the evaluators, policy makers, and high level scientific panels to stimulate the scientific intellects on identified indicators so that their work proceeds to generate productive outcome contributing to the economic growth. Copyright© Bentham Science

Disease epidemiology and genetic diversity of fusarium oxysporum f. sp. elaeidis, cause of fusarium wilt of oil palm (Elaeis guineensis Jacq.)

OpenAIRE

Hefni Rusli, M.; Wheals, Alan E.; Sharma, Sweta; Seman, Idris A.; Cooper, Richard M.

2017-01-01

Vascular wilt disease caused by Fusarium oxysporum f. sp. elaeidis (Foe) has devasted oil palm in west and central Africa. This study investigates the spatial distribution of Foe, whereby non-random, clustered patterns of the disease were recorded in four separate plantations in Ghana; infection from tree to tree via elongating roots therefore plays a more significant role than aerial distribution by conidiospores, with management implications. Control of Foe with disease-resistant palm lines...

Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.

Science.gov (United States)

Calderón-Garcidueñas, Lilian; Franco-Lira, Maricela; Mora-Tiscareño, Antonieta; Medina-Cortina, Humberto; Torres-Jardón, Ricardo; Kavanaugh, Michael

2013-01-01

Chronic exposure to particulate matter air pollution is known to cause inflammation leading to respiratory- and cardiovascular-related sickness and death. Mexico City Metropolitan Area children exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. Early dysregulated neuroinflammation, brain microvascular damage, production of potent vasoconstrictors, and perturbations in the integrity of the neurovascular unit likely contribute to progressive neurodegenerative processes. The accumulation of misfolded proteins coincides with the anatomical distribution observed in the early stages of both Alzheimer's and Parkinson's diseases. We contend misfolding of hyperphosphorylated tau (HPπ), alpha-synuclein, and beta-amyloid could represent a compensatory early protective response to the sustained systemic and brain inflammation. However, we favor the view that the chronic systemic and brain dysregulated inflammation and the diffuse vascular damage contribute to the establishment of neurodegenerative processes with childhood clinical manifestations. Friend turns Foe early; therefore, implementation of neuroprotective measures to ameliorate or stop the inflammatory and neurodegenerative processes is warranted in exposed children. Epidemiological, cognitive, structural, and functional neuroimaging and mechanistic studies into the association between air pollution exposures and the development of neuroinflammation and neurodegeneration in children are of pressing importance for public health.

Early Alzheimer's and Parkinson's Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence

Science.gov (United States)

Calderón-Garcidueñas, Lilian; Franco-Lira, Maricela; Mora-Tiscareño, Antonieta; Medina-Cortina, Humberto; Torres-Jardón, Ricardo; Kavanaugh, Michael

2013-01-01

Chronic exposure to particulate matter air pollution is known to cause inflammation leading to respiratory- and cardiovascular-related sickness and death. Mexico City Metropolitan Area children exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. Early dysregulated neuroinflammation, brain microvascular damage, production of potent vasoconstrictors, and perturbations in the integrity of the neurovascular unit likely contribute to progressive neurodegenerative processes. The accumulation of misfolded proteins coincides with the anatomical distribution observed in the early stages of both Alzheimer's and Parkinson's diseases. We contend misfolding of hyperphosphorylated tau (HPπ), alpha-synuclein, and beta-amyloid could represent a compensatory early protective response to the sustained systemic and brain inflammation. However, we favor the view that the chronic systemic and brain dysregulated inflammation and the diffuse vascular damage contribute to the establishment of neurodegenerative processes with childhood clinical manifestations. Friend turns Foe early; therefore, implementation of neuroprotective measures to ameliorate or stop the inflammatory and neurodegenerative processes is warranted in exposed children. Epidemiological, cognitive, structural, and functional neuroimaging and mechanistic studies into the association between air pollution exposures and the development of neuroinflammation and neurodegeneration in children are of pressing importance for public health. PMID:23509683

Learning SciPy for numerical and scientific computing

CERN Document Server

Silva

2013-01-01

A step-by-step practical tutorial with plenty of examples on research-based problems from various areas of science, that prove how simple, yet effective, it is to provide solutions based on SciPy. This book is targeted at anyone with basic knowledge of Python, a somewhat advanced command of mathematics/physics, and an interest in engineering or scientific applications---this is broadly what we refer to as scientific computing.This book will be of critical importance to programmers and scientists who have basic Python knowledge and would like to be able to do scientific and numerical computatio

Biomedical Scientific and Professional Social Networks in the Service of the Development of Modern Scientific Publishing.

Science.gov (United States)

Masic, Izet; Begic, Edin

2016-12-01

Information technologies have found their application in virtually every branch of health care. In recent years they have demonstrated their potential in the development of online library, where scientists and researchers can share their latest findings. Academia.edu, ResearchGate, Mendeley, Kudos, with the support of platform GoogleScholar, have indeed increased the visibility of scientific work of one author, and enable a much greater availability of the scientific work to the broader audience. Online libraries have allowed free access to the scientific content to the countries that could not follow the economic costs of getting access to certain scientific bases. Especially great benefit occurred in countries in transition and developing countries. Online libraries have great potential in terms of expanding knowledge, but they also present a major problem for many publishers, because their rights can be violated, which are signed by the author when publishing the paper. In the future it will lead to a major conflict of the author, the editorial board and online database, about the right to scientific content This question certainly represents one of the most pressing issues of publishing, whose future in printed form is already in the past, and the future of the online editions will be a problem of large-scale.

SELEKSI DAN PEMANFAATAN ACTINOMYCETES SEBAGAI MIKROBA ANTAGONIS YANG RAMAH LINGKUNGAN TERHADAP Fusarium oxysporum f.sp. cubense SECARA IN VITRO

Directory of Open Access Journals (Sweden)

I MADE SUDARMA

2015-06-01

Full Text Available A total of 119 different actinomycete isolate were recovered from banana crop habitats with and without Fusarium wilt disease symptom. These were than assessed for their antagonist ability against Fusarium oxysporum £sp. cubense (Foe in vitro. Results indicated that four of all actinomycete isolate active against Foe. The four of actinomycete isolates were Streptomyces sp. l (AAo4, Streptomyces sp.2 (AAo32 , Streptomyces sp.3 (AAo33 and Streptomyces sp. 4 (AAo35. It was can inhibit the Foe mycelium growth, 79,63%, 72,22%, 78,89% and 72,22% respectively. After tested with the 3 times replication, the four Streptomyces spp. isolate effective to control the Foe that attack Bali banana cultivars, such as Susu, Saba, Raja and Ketip.

1998-2001 Scientific Technological Report

International Nuclear Information System (INIS)

Gayoso C, C.; Ezpinoza Z, M.; Prado C, A.; Robles N, A.

2002-01-01

IPEN has elaborated the 1998-2001 Scientific-Technological Report as a result of several research and development works within the fields of production and services, and related with mining, archaeology, agriculture, biology, industry and medicine as well with tracer techniques in industry, welding quality control, speed and underground waters flows, direction, water treatment, environmental pollution, geothermy, production and calibration of radioactive sources, X-rays equipment quality control, neutron physics, neutron radiography, neutron activation analysis, water traces analysis, crystal growth and building of nuclear equipment. The 1998-2001 Scientific-Technological Report includes 148 papers divided in 8 subject matters: Nuclear and Reactor Physics, Nuclear Chemistry, Nuclear Engineering, Materials, Nuclear Safety, Protection and Radiological Safety, Nuclear Applications, and Rules and Regulation

Scientific visualization and radiology

International Nuclear Information System (INIS)

Lawrance, D.P.; Hoyer, C.E.; Wrestler, F.A.; Kuhn, M.J.; Moore, W.D.; Anderson, D.R.

1989-01-01

Scientific visualization is the visual presentation of numerical data. The National Center for Supercomputing Applications (NCSA) has developed methods for visualizing computerbased simulations of digital imaging data. The applicability of these various tools for unique and potentially medical beneficial display of MR images is investigated. Raw data are obtained from MR images of the brain, neck, spine, and brachial plexus obtained on a 1.5-T imager with multiple pulse sequences. A supercomputer and other mainframe resources run a variety of graphic and imaging programs using this data. An interdisciplinary team of imaging scientists, computer graphic programmers, an physicians works together to achieve useful information

Using cloud-computing applications to support collaborative scientific inquiry: Examining pre-service teachers’ perceived barriers towards integration / Utilisation d'applications infonuagiques pour appuyer la recherche scientifique collaborative

OpenAIRE

Joel Donna; Brant G Miller

2013-01-01

Technology plays a crucial role in facilitating collaboration within the scientific community. Cloud-computing applications can be used to model such collaboration and support inquiry within the secondary science classroom. Little is known about pre-service teachers’ beliefs related to the envisioned use of this technology in their teaching. These beliefs may influence future integration. This study finds several first-order barriers, such as perceptions that these tools would take too much t...

PROSCENIUM OF SCIENTIFIC MANAGEMENT

Directory of Open Access Journals (Sweden)

Vasile Berlingher

2013-09-01

Full Text Available During the last three decades of the nineteenth century, organizations developed rapidly, their managers began to realize that they had too frequent managerial problems; this awareness lead to a new phase of development of scientific management. Examining the titles published in that period, it can be concluded that management issues that pose interest related to payroll and payroll systems, problems exacerbated by the industrial revolution and related work efficiency. Noting that large organizations losing power, direct supervision, the managers were looking for incentives to replace this power . One of the first practitioners of this new management system was Henry R. Towne, the president of the well-known enterprise "Yale and Towne Manufacturing Company", which applied the management methods in his company workshops. Publishers of magazines "Industrial Management" and "The Engineering Magazine" stated that HR Towne is, undisputedly, the pioneer of scientific management. He initiated the systematic application of effective management methods and his famous article "The Engineer as Economist" provided to the company. "American Society of Mechanical Engineers" in 1886 was the one that probably inspired Frederick W. Taylor to devote his entire life and work in scientific management.

76 FR 63314 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2011-10-12

... for Scientific Review Special Emphasis Panel, PAR-10-235: Climate Change and Health. Date: November 8... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD 20892...

A practical guide to scientific data analysis

CERN Document Server

Livingstone, David J

2009-01-01

Inspired by the author's need for practical guidance in the processes of data analysis, A Practical Guide to Scientific Data Analysis has been written as a statistical companion for the working scientist.  This handbook of data analysis with worked examples focuses on the application of mathematical and statistical techniques and the interpretation of their results. Covering the most common statistical methods for examining and exploring relationships in data, the text includes extensive examples from a variety of scientific disciplines. The chapters are organised logically, from pl

Scientific activities 1980 Nuclear Research Center ''Democritos''

International Nuclear Information System (INIS)

1982-01-01

The scientific activities and achievements of the Nuclear Research Center Democritos for the year 1980 are presented in the form of a list of 76 projects giving title, objectives, responsible of each project, developed activities and the pertaining lists of publications. The 16 chapters of this work cover the activities of the main Divisions of the Democritos NRC: Electronics, Biology, Physics, Chemistry, Health Physics, Reactor, Scientific Directorate, Radioisotopes, Environmental Radioactivity, Soil Science, Computer Center, Uranium Exploration, Medical Service, Technological Applications, Radioimmunoassay and Training. (N.C.)

Final Scientific Report: DE-SC0008580

Energy Technology Data Exchange (ETDEWEB)

Seidler, Gerald T. [Univ. of Washington, Seattle, WA (United States)

2017-03-16

We report scientific, technical, and organizational accomplishments under DE-SC0008580. This includes 10 publications, 5 patent or provisional patent applications, beamtime with important results at both LCLS and APS, and new progress in understanding target design for x-ray heating experiments at x-ray heating facilities.

Scientific activities 1979

International Nuclear Information System (INIS)

1981-01-01

The scientific activities and achievements of the Nuclear Research Center Democritus for the year 1979 are presented in the form of a list of 78 projects giving title, objectives, commencement year, responsible of each project, developed activities and the pertaining lists of publications. The 15 chapters of this work cover the activities of the main Divisions of the Democritus NRC: Electronics, Biology, Physics, Chemistry, Health Physics, Reactor, Radioisotopes, Environmental Radioactivity, Soil Science, Computer Center, Uranium Exploration, Medical Service, Technological Applications and Training. (T.A.)

New methods to interpolate large volume of data from points or particles (Mesh-Free) methods application for its scientific visualization

International Nuclear Information System (INIS)

Reyes Lopez, Y.; Yervilla Herrera, H.; Viamontes Esquivel, A.; Recarey Morfa, C. A.

2009-01-01

In the following paper we developed a new method to interpolate large volumes of scattered data, focused mainly on the results of the Mesh free Methods, Points Methods and the Particles Methods application. Through this one, we use local radial basis function as interpolating functions. We also use over-tree as the data structure that allows to accelerate the localization of the data that influences to interpolate the values at a new point, speeding up the application of scientific visualization techniques to generate images from large data volumes from the application of Mesh-free Methods, Points and Particle Methods, in the resolution of diverse models of physics-mathematics. As an example, the results obtained after applying this method using the local interpolation functions of Shepard are shown. (Author) 22 refs

RSYST: From nuclear reactor calculations towards a highly sophisticated scientific software integration environment

International Nuclear Information System (INIS)

Noack, M.; Seybold, J.; Ruehle, R.

1996-01-01

The software environment RSYST was originally used to solve problems of reactor physics. The consideration of advanced scientific simulation requirements and the strict application of modern software design principles led to a system which is perfectly suitable to solve problems in various complex scientific problem domains. Starting with a review of the early days of RSYST, we describe the straight evolution driven by the need of software environment which combines the advantages of a high-performance database system with the capability to integrate sophisticated scientific technical applications. The RSYST architecture is presented and the data modelling capabilities are described. To demonstrate the powerful possibilities and flexibility of the RSYST environment, we describe a wide range of RSYST applications, e.g., mechanical simulations of multibody systems, which are used in biomechanical research, civil engineering and robotics. In addition, a hypermedia system which is used for scientific technical training and documentation is presented. (orig.) [de

Plagiarism in scientific publishing.

Science.gov (United States)

Masic, Izet

2012-12-01

scientific research and intellectual honesty of researchers which would be absolutely applicable in all situations and in all research institutions. A special form of plagiarism is self-plagiarism. Scientists need to take into consideration this form of plagiarism, though for now there is an attitude as much as their own words can be used without the word about plagiarism. If the authors cite their own research facilities already stated then they should be put in quote sand cite the source in which it was published. Science should not be exempt from disclosure and sanctioning plagiarism. In the fight against intellectual dishonesty on ethics education in science has a significant place. A general understanding of ethics in scientific research work in all its stages had to be acquired during the undergraduate course and continue to intensify. It is also important ethical aspect of the publishing industry,especially in small and developing economies,because the issuer has an educational role in the development of the scientific community that aspires to relish so. In this paper author describe his experiences in discovering of plagiarism as Editor-in-Chief of three indexed medical journals with presentations of several examples of plagiarism recorded in countries in Southeastern Europe.

Cross-language Babel structs—making scientific interfaces more efficient

International Nuclear Information System (INIS)

Prantl, Adrian; Epperly, Thomas G W; Ebner, Dietmar

2013-01-01

Babel is an open-source language interoperability framework tailored to the needs of high-performance scientific computing. As an integral element of the Common Component Architecture, it is employed in a wide range of scientific applications where it is used to connect components written in different programming languages. In this paper we describe how we extended Babel to support interoperable tuple data types (structs). Structs are a common idiom in (mono-lingual) scientific application programming interfaces (APIs); they are an efficient way to pass tuples of nonuniform data between functions, and are supported natively by most programming languages. Using our extended version of Babel, developers of scientific codes can now pass structs as arguments between functions implemented in any of the supported languages. In C, C++, Fortran 2003/2008 and Chapel, structs can be passed without the overhead of data marshaling or copying, providing language interoperability at minimal cost. Other supported languages are Fortran 77, Fortran 90/95, Java and Python. We will show how we designed a struct implementation that is interoperable with all of the supported languages and present benchmark data to compare the performance of all language bindings, highlighting the differences between languages that offer native struct support and an object-oriented interface with getter/setter methods. A case study shows how structs can help simplify the interfaces of scientific codes significantly. (paper)

Popularization of science and scientific journalism: possibilities of scientific literacy

Directory of Open Access Journals (Sweden)

Alessandro Augusto Barros Façanha

2017-07-01

Full Text Available This study evidences the intersection between science education and communication in the perspective of the popularization of sciences based on the evidence produced in a specific column of a large circulation newspaper of the city of Teresina / PI. The discussions were based on the analysis of content carried out in the context of science classes in a school of basic education with elementary students, where journalistic texts were used with diverse themes that involved science and daily life in order to understand the interpretation of texts And the relationship with the context of scientific dissemination and citizenship. The analysis of the content was used and the answers were stratified into categories of conceptual nature and application of the themes. The analyses show that the texts of scientific dissemination have a contribution in relation to the popularization of Sciences, fomentation to the debate in the classroom, didactic increment in the classes of sciences, in spite of their insertion still incipient in the context of science education. However, the results of the research denote the difficulty faced by the students in understanding the text of dissemination in their conceptual comprehension and resolution of daily problems, as well as the distance between the context of the sciences in their theoretical scope and their presentation in everyday situations, Despite this, the texts of divulgation corroborated as an important way of real insertion in the process of scientific literacy and promotion of citizenship.

geo-scientific indicators for safety

International Nuclear Information System (INIS)

Andersson, J.; Bruno, G.; Deguchi, A.; Fein, E.; Larue, P.J.; Lei, S.; Leung, H.; Norris, S.; Violette, S.; Wollrath, J.

2007-01-01

Working Group A was continuation of Working Group B of AMIGO-1, but participants explored more deeply the issues surrounding geo-scientific indicators for safety. The following outcomes were expected. - List different geo-scientific arguments or indicators for safety (with motivation) for various host rocks and sites. Consider dividing the arguments into those that support isolation or retention and discuss their applicability for different time frames. - What actual measurable field evidence supports these arguments/indicators? - What kind of field evidence would go counter to these safety arguments? - What key messages are the most promising in terms of scientific credibility to contribute to the safety case? Possibly examine the same message but in terms of potential ease of communication. The session started with two introductory presentations: - Following the presentations, in discussion the Working Group listed: - Safety Functions where geo-scientific support is needed; - Commonly used chains of argument for supporting these safety functions; - Whether the applicability of the arguments are host rock or site specific and how they apply for different time frames; - Field evidence or other issues that would go counter to the safety arguments; - Key messages most promising in terms of scientific credibility to contribute to the safety case. Overall it was concluded by the Working Group that: - The most important argument is to present a clear understanding of past geological evolution at the particular site, consistent with the global understanding of geological evolution. Efforts should be made to achieve a broad consensus on this from many independent experts. - The supporting arguments are seldom based on a single piece of evidence. It is the chain of arguments rather than individual arguments that is important. - We are primarily interested in 'reasonable' predictability of the geological system. We recognize that most geological systems evolve with time

Scientific instruments, scientific progress and the cyclotron

International Nuclear Information System (INIS)

Baird, David; Faust, Thomas

1990-01-01

Philosophers speak of science in terms of theory and experiment, yet when they speak of the progress of scientific knowledge they speak in terms of theory alone. In this article it is claimed that scientific knowledge consists of, among other things, scientific instruments and instrumental techniques and not simply of some kind of justified beliefs. It is argued that one aspect of scientific progress can be characterized relatively straightforwardly - the accumulation of new scientific instruments. The development of the cyclotron is taken to illustrate this point. Eight different activities which promoted the successful completion of the cyclotron are recognised. The importance is in the machine rather than the experiments which could be run on it and the focus is on how the cyclotron came into being, not how it was subsequently used. The completed instrument is seen as a useful unit of scientific progress in its own right. (UK)

Research governance and scientific knowledge production in The Gambia

Directory of Open Access Journals (Sweden)

Frederick U. Ozor

2014-09-01

Full Text Available Public research institutions and scientists are principal actors in the production and transfer of scientific knowledge, technologies and innovations for application in industry as well for social and economic development. Based on the relevance of science and technology actors, the aim of this study was to identify and explain factors in research governance that influence scientific knowledge production and to contribute to empirical discussions on the impact levels of different governance models and structures. These discussions appear limited and mixed in the literature, although still are ongoing. No previous study has examined the possible contribution of the scientific committee model of research governance to scientific performance at the individual level of the scientist. In this context, this study contributes to these discussions, firstly, by suggesting that scientific committee structures with significant research steering autonomy could contribute not only directly to scientific output but also indirectly through moderating effects on research practices. Secondly, it is argued that autonomous scientific committee structures tend to play a better steering role than do management-centric models and structures of research governance.

Application of the opportunities of tool system 'CUDA' for graphic processors programming in scientific and technical calculation tasks

International Nuclear Information System (INIS)

Dudnik, V.A.; Kudryavtsev, V.I.; Sereda, T.M.; Us, S.A.; Shestakov, M.V.

2009-01-01

The opportunities of technology CUDA (Compute Unified Device Architecture - the unified hardware-software decision for parallel calculations on GPU)of the company NVIDIA were described. The basic differences of the programming language 'C' for GPU from 'usual' language 'C' were selected. The examples of CUDA usage for acceleration of development of applications and realization of algorithms of scientific and technical calculations were given which are carried out by the means of graphic processors (GPGPU) of accelerators GeForce of the eighth generation. The recommendations on optimization of the programs using GPU were resulted.

Energy Smart Management of Scientific Data

Energy Technology Data Exchange (ETDEWEB)

Otoo, Ekow; Rotem, Dron; Tsao, Shih-Chiang

2009-04-12

Scientific data centers comprised of high-powered computing equipment and large capacity disk storage systems consume considerable amount of energy. Dynamic power management techniques (DPM) are commonly used for saving energy in disk systems. These involve powering down disks that exhibit long idle periods and placing them in standby mode. A file request from a disk in standby mode will incur both energy and performance penalties as it takes energy (and time) to spin up the disk before it can serve a file. For this reason, DPM has to make decisions as to when to transition the disk into standby mode such that the energy saved is greater than the energy needed to spin it up again and the performance penalty is tolerable. The length of the idle period until the DPM decides to power down a disk is called idlenessthreshold. In this paper, we study both analytically and experimentally dynamic power management techniques that save energy subject to performance constraints on file access costs. Based on observed workloads of scientific applications and disk characteristics, we provide a methodology for determining file assignment to disks and computing idleness thresholds that result in significant improvements to the energy saved by existing DPMsolutions while meeting response time constraints. We validate our methods with simulations that use traces taken from scientific applications.

Topological data analysis for scientific visualization

CERN Document Server

Tierny, Julien

2017-01-01

Combining theoretical and practical aspects of topology, this book delivers a comprehensive and self-contained introduction to topological methods for the analysis and visualization of scientific data. Theoretical concepts are presented in a thorough but intuitive manner, with many high-quality color illustrations. Key algorithms for the computation and simplification of topological data representations are described in details, and their application is carefully illustrated in a chapter dedicated to concrete use cases. With its fine balance between theory and practice, "Topological Data Analysis for Scientific Visualization" constitutes an appealing introduction to the increasingly important topic of topological data analysis, for lecturers, students and researchers.

Brand alliance. Building block for scientific organisations´ marketing strategy

Directory of Open Access Journals (Sweden)

Joern Redler

2016-03-01

Full Text Available This paper addresses management issues of brand alliances as part of a scientific organisation´s marketing strategy. Though brand alliances have become quite popular with consumer products they seem to be exceptions in the marketing context of academic or scientific organisations. Against this background, the paper develops a brand alliance approach considering requirements of strategically marketing scientific organisations. As a starting point, brand alliances are discussed as a sub-category to brand combinations. Furthermore, opportunities for scientific organisations associated with the alliance approach are elucidated as well as, from a more general perspective, major threats. In the following course, the paper focuses on modelling a framework of customer-based brand alliance effects, referring to the behavioural science-based view of brands which conceptualises brands as the psychological reaction to the exposure of brand elements like a name, logo or symbols. In that context, prerequisites for success are examined as well. Further, essential components of a brand alliance management process are discussed and its application to scientific organisations is expounded. Aspects like, e.g., choosing and evaluating a partner brand, positioning a brand alliance or monitoring brand alliance performance are illuminated. In regard to practical application also factors and requirements for organisation´s brand alliance success are outlined.

Complexity-Based Modeling of Scientific Capital: An Outline of Mathematical Theory

Directory of Open Access Journals (Sweden)

Yurij L. Katchanov

2014-01-01

measuring and assessing the accumulated recognition and the specific scientific power. The concept of scientific capital developed by Bourdieu is used in international social science research to explain a set of scholarly properties and practices. Mathematical modeling is applied as a lens through which the scientific capital is addressed. The principal contribution of this paper is an axiomatic characterization of scientific capital in terms of natural axioms. The application of the axiomatic method to scientific capital reveals novel insights into problem still not covered by mathematical modeling. Proposed model embraces the interrelations between separate sociological variables, providing a unified sociological view of science. Suggested microvariational principle is based upon postulate, which affirms that (under suitable conditions the observed state of the agent in scientific field maximizes scientific capital. Its value can be roughly imagined as a volume of social differences. According to the considered macrovariational principle, the actual state of scientific field makes so-called energy functional (which is associated with the distribution of scientific capital minimal.

75 FR 3542 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

Science.gov (United States)

2010-01-21

... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... (Federal Advisory Committee Act) that the Rehabilitation Research and Development Service Scientific Merit... Board is to review rehabilitation research and development applications for scientific and technical...

75 FR 40036 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

Science.gov (United States)

2010-07-13

... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... (Federal Advisory Committee Act) that the Rehabilitation Research and Development Service Scientific Merit... is to review rehabilitation research and development applications for scientific and technical merit...

EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2013. Scientific and technical guidance for the preparation and presentation of applications pursuant to Article 6 Paragraph 11 of Directive 2000/13/EC, as amended

DEFF Research Database (Denmark)

Tetens, Inge

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on Scientific and technical guidance for the preparation and presentation of applications pursuant to Article 6 Paragraph 11 of Directive 2000....../13/EC, as amended. This guidance applies to food ingredients or substances with known allergenic potential listed in Annex IIIa of 2003/89/EC (as amended) or products thereof, and aims to assist applicants in the preparation and presentation of well-structured applications for exemption from labelling....... It presents a common format for the organisation of the information to be provided and outlines the information and scientific data which must be included in the application, the hierarchy of different types of data and study designs, reflecting the relative strength of evidence which may be obtained from...

PLAGIARISM IN SCIENTIFIC PUBLISHING

Science.gov (United States)

Masic, Izet

2012-01-01

scientific research and intellectual honesty of researchers which would be absolutely applicable in all situations and in all research institutions. A special form of plagiarism is self-plagiarism. Scientists need to take into consideration this form of plagiarism, though for now there is an attitude as much as their own words can be used without the word about plagiarism. If the authors cite their own research facilities already stated then they should be put in quote sand cite the source in which it was published. Science should not be exempt from disclosure and sanctioning plagiarism. In the fight against intellectual dishonesty on ethics education in science has a significant place. A general understanding of ethics in scientific research work in all its stages had to be acquired during the undergraduate course and continue to intensify. It is also important ethical aspect of the publishing industry,especially in small and developing economies,because the issuer has an educational role in the development of the scientific community that aspires to relish so. In this paper author describe his experiences in discovering of plagiarism as Editor-in-Chief of three indexed medical journals with presentations of several examples of plagiarism recorded in countries in Southeastern Europe. PMID:23378684

SALTON SEA SCIENTIFIC DRILLING PROJECT: SCIENTIFIC PROGRAM.

Science.gov (United States)

Sass, J.H.; Elders, W.A.

1986-01-01

The Salton Sea Scientific Drilling Project, was spudded on 24 October 1985, and reached a total depth of 10,564 ft. (3. 2 km) on 17 March 1986. There followed a period of logging, a flow test, and downhole scientific measurements. The scientific goals were integrated smoothly with the engineering and economic objectives of the program and the ideal of 'science driving the drill' in continental scientific drilling projects was achieved in large measure. The principal scientific goals of the project were to study the physical and chemical processes involved in an active, magmatically driven hydrothermal system. To facilitate these studies, high priority was attached to four areas of sample and data collection, namely: (1) core and cuttings, (2) formation fluids, (3) geophysical logging, and (4) downhole physical measurements, particularly temperatures and pressures.

From Data to Knowledge to Discoveries: Artificial Intelligence and Scientific Workflows

Directory of Open Access Journals (Sweden)

Yolanda Gil

2009-01-01

Full Text Available Scientific computing has entered a new era of scale and sharing with the arrival of cyberinfrastructure facilities for computational experimentation. A key emerging concept is scientific workflows, which provide a declarative representation of complex scientific applications that can be automatically managed and executed in distributed shared resources. In the coming decades, computational experimentation will push the boundaries of current cyberinfrastructure in terms of inter-disciplinary scope and integrative models of scientific phenomena under study. This paper argues that knowledge-rich workflow environments will provide necessary capabilities for that vision by assisting scientists to validate and vet complex analysis processes and by automating important aspects of scientific exploration and discovery.

State of the art of parallel scientific visualization applications on PC clusters; Etat de l'art des applications de visualisation scientifique paralleles sur grappes de PC

Energy Technology Data Exchange (ETDEWEB)

Juliachs, M

2004-07-01

In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

NOAA's Scientific Data Stewardship Program

Science.gov (United States)

Bates, J. J.

2004-12-01

The NOAA mission is to understand and predict changes in the Earth's environment and conserve and manage coastal and marine resources to meet the Nation's economic, social and environmental needs. NOAA has responsibility for long-term archiving of the United States environmental data and has recently integrated several data management functions into a concept called Scientific Data Stewardship. Scientific Data Stewardship a new paradigm in data management consisting of an integrated suite of functions to preserve and exploit the full scientific value of NOAA's, and the world's, environmental data These functions include careful monitoring of observing system performance for long-term applications, the generation of authoritative long-term climate records from multiple observing platforms, and the proper archival of and timely access to data and metadata. NOAA has developed a conceptual framework to implement the functions of scientific data stewardship. This framework has five objectives: 1) develop real-time monitoring of all satellite observing systems for climate applications, 2) process large volumes of satellite data extending up to decades in length to account for systematic errors and to eliminate artifacts in the raw data (referred to as fundamental climate data records, FCDRs), 3) generate retrieved geophysical parameters from the FCDRs (referred to as thematic climate data records TCDRs) including combining observations from all sources, 4) conduct monitoring and research by analyzing data sets to uncover climate trends and to provide evaluation and feedback for steps 2) and 3), and 5) provide archives of metadata, FCDRs, and TCDRs, and facilitate distribution of these data to the user community. The term `climate data record' and related terms, such as climate data set, have been used for some time, but the climate community has yet to settle on a concensus definition. A recent United States National Academy of Sciences report recommends using the

1999 scientific evaluation at the CEA; L'evaluation scientifique 1999 au CEA

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-07-01

This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members.

Scheduling Multilevel Deadline-Constrained Scientific Workflows on Clouds Based on Cost Optimization

Directory of Open Access Journals (Sweden)

Maciej Malawski

2015-01-01

Full Text Available This paper presents a cost optimization model for scheduling scientific workflows on IaaS clouds such as Amazon EC2 or RackSpace. We assume multiple IaaS clouds with heterogeneous virtual machine instances, with limited number of instances per cloud and hourly billing. Input and output data are stored on a cloud object store such as Amazon S3. Applications are scientific workflows modeled as DAGs as in the Pegasus Workflow Management System. We assume that tasks in the workflows are grouped into levels of identical tasks. Our model is specified using mathematical programming languages (AMPL and CMPL and allows us to minimize the cost of workflow execution under deadline constraints. We present results obtained using our model and the benchmark workflows representing real scientific applications in a variety of domains. The data used for evaluation come from the synthetic workflows and from general purpose cloud benchmarks, as well as from the data measured in our own experiments with Montage, an astronomical application, executed on Amazon EC2 cloud. We indicate how this model can be used for scenarios that require resource planning for scientific workflows and their ensembles.

Experimental and Theoretical Researches of a Resonator Concept of a Dielectric Wakefield Accelerator

International Nuclear Information System (INIS)

Onishchenko, I.N.; Kiselev, V.A.; Linnik, A.F.; Onishchenko, N.I.; Sotnikov, G.V.; Uskov, V.V.

2006-01-01

Wakefield excitation in a cylindrical dielectric waveguide or resonator by a regular sequence of electron bunches foe application to high-gradient particle acceleration has been investigated theoretically and experimentally using an electron linac 'ALMAZ-2' (4.5 MeV, 6.10 3 bunches of duration 60 ps and charge 0.32 nC each)

Early Alzheimer’s and Parkinson’s Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the Evidence

Directory of Open Access Journals (Sweden)

Lilian Calderón-Garcidueñas

2013-01-01

Full Text Available Chronic exposure to particulate matter air pollution is known to cause inflammation leading to respiratory- and cardiovascular-related sickness and death. Mexico City Metropolitan Area children exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. Early dysregulated neuroinflammation, brain microvascular damage, production of potent vasoconstrictors, and perturbations in the integrity of the neurovascular unit likely contribute to progressive neurodegenerative processes. The accumulation of misfolded proteins coincides with the anatomical distribution observed in the early stages of both Alzheimer’s and Parkinson's diseases. We contend misfolding of hyperphosphorylated tau (HPπ, alpha-synuclein, and beta-amyloid could represent a compensatory early protective response to the sustained systemic and brain inflammation. However, we favor the view that the chronic systemic and brain dysregulated inflammation and the diffuse vascular damage contribute to the establishment of neurodegenerative processes with childhood clinical manifestations. Friend turns Foe early; therefore, implementation of neuroprotective measures to ameliorate or stop the inflammatory and neurodegenerative processes is warranted in exposed children. Epidemiological, cognitive, structural, and functional neuroimaging and mechanistic studies into the association between air pollution exposures and the development of neuroinflammation and neurodegeneration in children are of pressing importance for public health.

The RCF and government policy. Proof of evidence

International Nuclear Information System (INIS)

Green, P.; Western, R.

1996-01-01

Proof of Evidence by an expert witness is presented in support of the case by Friends of the Earth (FOE) against the proposed construction by UK Nirex Ltd of an underground Rock Characterisation Facility (RCF) at a site in the Sellafield area. The RCF is part of an investigation by Nirex into a suitable site for an uderground repository for the disposal of radioactive waste. The objections were raised at a Planning Inquiry in 1995. This evidence examines Nirex's proposal in the light of UK Government Policy on radioactive waste disposal and in particular recent significant changes. These changes, set out in a White Paper in July 1995, specify scientific and sustainability criteria which in the view of FOE are not met by Nirex's research relating to the site and especially to the RCF. It is concluded that planning permission should not be granted in the light of the large amount of further work that needs to be undertaken before construction, the length of time this would take, and the lack of a properly validated baseline model of existing conditions at the site. (43 references). (UK)

Research governance and scientific knowledge production in The Gambia

OpenAIRE

Frederick U. Ozor

2014-01-01

Public research institutions and scientists are principal actors in the production and transfer of scientific knowledge, technologies and innovations for application in industry as well for social and economic development. Based on the relevance of science and technology actors, the aim of this study was to identify and explain factors in research governance that influence scientific knowledge production and to contribute to empirical discussions on the impact levels of different governance m...

Pascal-SC a computer language for scientific computation

CERN Document Server

Bohlender, Gerd; von Gudenberg, Jürgen Wolff; Rheinboldt, Werner; Siewiorek, Daniel

1987-01-01

Perspectives in Computing, Vol. 17: Pascal-SC: A Computer Language for Scientific Computation focuses on the application of Pascal-SC, a programming language developed as an extension of standard Pascal, in scientific computation. The publication first elaborates on the introduction to Pascal-SC, a review of standard Pascal, and real floating-point arithmetic. Discussions focus on optimal scalar product, standard functions, real expressions, program structure, simple extensions, real floating-point arithmetic, vector and matrix arithmetic, and dynamic arrays. The text then examines functions a

EFSA Scientific Committee; Scientific Opinion on Risk Assessment Terminology

DEFF Research Database (Denmark)

Hald, Tine

of improving the expression and communication of risk and/or uncertainties in the selected opinions. The Scientific Committee concluded that risk assessment terminology is not fully harmonised within EFSA. In part this is caused by sectoral legislation defining specific terminology and international standards......The Scientific Committee of the European Food Safety Authority (EFSA) reviewed the use of risk assessment terminology within its Scientific Panels. An external report, commissioned by EFSA, analysed 219 opinions published by the Scientific Committee and Panels to recommend possible ways......, the Scientific Committee concludes that particular care must be taken that the principles of CAC, OIE or IPPC are followed strictly. EFSA Scientific Panels should identify which specific approach is most useful in dealing with their individual mandates. The Scientific Committee considered detailed aspects...

A Lightweight I/O Scheme to Facilitate Spatial and Temporal Queries of Scientific Data Analytics

Science.gov (United States)

Tian, Yuan; Liu, Zhuo; Klasky, Scott; Wang, Bin; Abbasi, Hasan; Zhou, Shujia; Podhorszki, Norbert; Clune, Tom; Logan, Jeremy; Yu, Weikuan

2013-01-01

In the era of petascale computing, more scientific applications are being deployed on leadership scale computing platforms to enhance the scientific productivity. Many I/O techniques have been designed to address the growing I/O bottleneck on large-scale systems by handling massive scientific data in a holistic manner. While such techniques have been leveraged in a wide range of applications, they have not been shown as adequate for many mission critical applications, particularly in data post-processing stage. One of the examples is that some scientific applications generate datasets composed of a vast amount of small data elements that are organized along many spatial and temporal dimensions but require sophisticated data analytics on one or more dimensions. Including such dimensional knowledge into data organization can be beneficial to the efficiency of data post-processing, which is often missing from exiting I/O techniques. In this study, we propose a novel I/O scheme named STAR (Spatial and Temporal AggRegation) to enable high performance data queries for scientific analytics. STAR is able to dive into the massive data, identify the spatial and temporal relationships among data variables, and accordingly organize them into an optimized multi-dimensional data structure before storing to the storage. This technique not only facilitates the common access patterns of data analytics, but also further reduces the application turnaround time. In particular, STAR is able to enable efficient data queries along the time dimension, a practice common in scientific analytics but not yet supported by existing I/O techniques. In our case study with a critical climate modeling application GEOS-5, the experimental results on Jaguar supercomputer demonstrate an improvement up to 73 times for the read performance compared to the original I/O method.

Floods and droughts: friends or foes?

Science.gov (United States)

Prudhomme, Christel

2017-04-01

Water hazards are some of the biggest threats to lives and livelihoods globally, causing serious damages to society and infrastructure. But floods and droughts are an essential part of the hydrological regime that ensures fundamental ecosystem functions, providing natural ways to bring in nutrients, flush out pollutants and enabling soils, rivers and lakes natural biodiversity to thrive. Traditionally, floods and droughts are too often considered separately, with scientific advance in process understanding, modelling, statistical characterisation and impact assessment are often done independently, possibly delaying the development of innovative methods that could be applied to both. This talk will review some of the key characteristics of floods and droughts, highlighting differences and commonalties, losses and benefits, with the aim of identifying future key research challenges faced by both current and next generation of hydrologists.

A high performance scientific cloud computing environment for materials simulations

Science.gov (United States)

Jorissen, K.; Vila, F. D.; Rehr, J. J.

2012-09-01

We describe the development of a scientific cloud computing (SCC) platform that offers high performance computation capability. The platform consists of a scientific virtual machine prototype containing a UNIX operating system and several materials science codes, together with essential interface tools (an SCC toolset) that offers functionality comparable to local compute clusters. In particular, our SCC toolset provides automatic creation of virtual clusters for parallel computing, including tools for execution and monitoring performance, as well as efficient I/O utilities that enable seamless connections to and from the cloud. Our SCC platform is optimized for the Amazon Elastic Compute Cloud (EC2). We present benchmarks for prototypical scientific applications and demonstrate performance comparable to local compute clusters. To facilitate code execution and provide user-friendly access, we have also integrated cloud computing capability in a JAVA-based GUI. Our SCC platform may be an alternative to traditional HPC resources for materials science or quantum chemistry applications.

Scientific Data Management Center for Enabling Technologies

Energy Technology Data Exchange (ETDEWEB)

Vouk, Mladen A.

2013-01-15

Managing scientific data has been identified by the scientific community as one of the most important emerging needs because of the sheer volume and increasing complexity of data being collected. Effectively generating, managing, and analyzing this information requires a comprehensive, end-to-end approach to data management that encompasses all of the stages from the initial data acquisition to the final analysis of the data. Fortunately, the data management problems encountered by most scientific domains are common enough to be addressed through shared technology solutions. Based on community input, we have identified three significant requirements. First, more efficient access to storage systems is needed. In particular, parallel file system and I/O system improvements are needed to write and read large volumes of data without slowing a simulation, analysis, or visualization engine. These processes are complicated by the fact that scientific data are structured differently for specific application domains, and are stored in specialized file formats. Second, scientists require technologies to facilitate better understanding of their data, in particular the ability to effectively perform complex data analysis and searches over extremely large data sets. Specialized feature discovery and statistical analysis techniques are needed before the data can be understood or visualized. Furthermore, interactive analysis requires techniques for efficiently selecting subsets of the data. Finally, generating the data, collecting and storing the results, keeping track of data provenance, data post-processing, and analysis of results is a tedious, fragmented process. Tools for automation of this process in a robust, tractable, and recoverable fashion are required to enhance scientific exploration. The SDM center was established under the SciDAC program to address these issues. The SciDAC-1 Scientific Data Management (SDM) Center succeeded in bringing an initial set of advanced

Combler l'écart entre la recherche et le savoir | IDRC - International ...

International Development Research Centre (IDRC) Digital Library (Canada)

7 janv. 2011 ... Selon les professeurs Chevalier et Buckles, il est plus urgent que jamais de faire participer tous les êtres humains, sans exception, à l'application et à la coproduction de connaissances. Le défi consiste à « porter au carré ... Trade liberalization: Poverty's friend or foe? They are the familiar images of global ...

78 FR 12422 - Health Services Research and Development Service Scientific Merit Review Board, Notice of Meeting

Science.gov (United States)

2013-02-22

... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit... nursing research. Applications are reviewed for scientific and technical merit, mission relevance, and the... Program Manager, Scientific Merit Review Board, Department of Veterans Affairs, Health Services Research...

Ontological Order in Scientific Explanation | Park | Philosophical ...

African Journals Online (AJOL)

A conceptually sound explanation, I claim, respects the ontological order between properties. A dependent property is to be explained in terms of its underlying property, not the other way around. The applicability of this point goes well beyond the realm of the debate between scientific realists and antirealists.

77 FR 26507 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2012-05-04

... States. Application accepted by Commissioner of Customs: March 29, 2012. Docket Number: 12-018. Applicant... general category manufactured in the United States. Application accepted by Commissioner of Customs: March...: The instrument will be used to investigate the genes and proteins that underlie normal and pathologic...

The Effectiveness of Scientific Inquiry With/Without Integration of Scientific Reasoning

Science.gov (United States)

Chen, Chun-Ting; She, Hsiao-Ching

2015-01-01

This study examines the difference in effectiveness between two scientific inquiry programs-one with an emphasis on scientific reasoning and one without a scientific reasoning component-on students' scientific concepts, scientific concept-dependent reasoning, and scientific inquiry. A mixed-method approach was used in which 115 grade 5…

State of the art of parallel scientific visualization applications on PC clusters; Etat de l'art des applications de visualisation scientifique paralleles sur grappes de PC

Energy Technology Data Exchange (ETDEWEB)

Juliachs, M

2004-07-01

In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

78 FR 6854 - Health Services Research and Development Service Scientific Merit Review Board; Notice of Meeting

Science.gov (United States)

2013-01-31

... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit... Research and Development Service Scientific Merit Review Board will meet on February 13-14, 2013, at the... research. Applications are reviewed for scientific and technical merit. Recommendations regarding funding...

Secure Peer-to-Peer Networks for Scientific Information Sharing

Science.gov (United States)

Karimabadi, Homa

2012-01-01

The most common means of remote scientific collaboration today includes the trio of e-mail for electronic communication, FTP for file sharing, and personalized Web sites for dissemination of papers and research results. With the growth of broadband Internet, there has been a desire to share large files (movies, files, scientific data files) over the Internet. Email has limits on the size of files that can be attached and transmitted. FTP is often used to share large files, but this requires the user to set up an FTP site for which it is hard to set group privileges, it is not straightforward for everyone, and the content is not searchable. Peer-to-peer technology (P2P), which has been overwhelmingly successful in popular content distribution, is the basis for development of a scientific collaboratory called Scientific Peer Network (SciPerNet). This technology combines social networking with P2P file sharing. SciPerNet will be a standalone application, written in Java and Swing, thus insuring portability to a number of different platforms. Some of the features include user authentication, search capability, seamless integration with a data center, the ability to create groups and social networks, and on-line chat. In contrast to P2P networks such as Gnutella, Bit Torrent, and others, SciPerNet incorporates three design elements that are critical to application of P2P for scientific purposes: User authentication, Data integrity validation, Reliable searching SciPerNet also provides a complementary solution to virtual observatories by enabling distributed collaboration and sharing of downloaded and/or processed data among scientists. This will, in turn, increase scientific returns from NASA missions. As such, SciPerNet can serve a two-fold purpose for NASA: a cost-savings software as well as a productivity tool for scientists working with data from NASA missions.

Emerging scientific advances: how do they enter dental curricula and the profession?

Science.gov (United States)

Shuler, Charles F

2005-10-01

What is meant by emerging scientific advances? In brief, this terminology is equivalent to new research findings, however, the term "research" is often associated with scientific investigations that have very limited direct clinical relevance. Unfortunately, basic dental research and dental clinical practice have, in many instances, been considered to have nonoverlapping spheres of existence. The existence of mutually exclusive domains is rapidly changing with considerable translational activities between basic research investigation and clinical application developing. There is a growing emphasis at a national level for the importance of moving basic biomedical research laboratory findings into clinical patient-related applications to realize improvements in health based on the research findings. Ultimately, new approaches to diagnose, treat, and prevent disease will be available and represent the translation of the best scientific evidence into clinical applications. It is critical at this time to prepare our dental graduates to be members of the dental profession who will understand the implications that new scientific advances will have on their approach to patient care. The patterns and practices of oral health care delivery will undergo major changes during the careers of our new dental graduates. They need to be prepared to respond to these changes to the benefit of their patients.

The Coastal Zone: Man and Nature. An Application of the Socio-Scientific Reasoning Model.

Science.gov (United States)

Maul, June Paradise; And Others

The curriculum model described here has been designed by incorporating the socio-scientific reasoning model with a simulation design in an attempt to have students investigate the onshore impacts of Outer Continental Shelf (OCS) gas and oil development. The socio-scientific reasoning model incorporates a logical/physical reasoning component as…

1999 scientific evaluation at the CEA; L'evaluation scientifique 1999 au CEA

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-07-01

This report presents a statement of the scientific and technical activity of the French atomic energy commission (CEA) for the year 1999. This evaluation is made by external and independent experts and requires some specific dispositions for the nuclear protection and safety institute (IPSN) and for the direction of military applications (DAM). The report is divided into 4 parts dealing successively with: 1)the CEA, a public research organization (strategy, research programs, new organization of the CEA activities, civil nuclear research, technology research and transfer, defence activities, transfer of knowledge) 2)the scientific evaluation at the CEA (evaluations of the civil applications of the CEA, IPSN, DAM, INSTN (national institute for nuclear sciences and techniques) 3)synthesis of the 1999 scientific and technical evaluation for each operational directions of the CEA (directions of fuel cycle, of nuclear reactors, of advanced technologies, of materials sciences, of life sciences, of military applications, of the nuclear protection and safety institute and of the national institute for nuclear sciences and techniques) 4)the corresponding members of the evaluation and the list of scientific and technical councils and members.

Human capital, social capital and scientific research in Europe: an application of linear hierarchical models

OpenAIRE

Mathieu Goudard; Michel Lubrano

2011-01-01

The theory of human capital is one way to explain individual decisions to produce scientific research. However, this theory, even if it reckons the importance of time in science, is too short for explaining the existing diversity of scientific output. The present paper introduces the social capital of Bourdieu (1980), Coleman (1988) and Putnam (1995) as a necessary complement to explain the creation of scientific human capital. This paper connects these two concepts by means of a hierarchical...

Integrating a work-flow engine within a commercial SCADA to build end users applications in a scientific environment

International Nuclear Information System (INIS)

Ounsy, M.; Pierre-Joseph Zephir, S.; Saintin, K.; Abeille, G.; Ley, E. de

2012-01-01

To build integrated high-level applications, SOLEIL is using an original component-oriented approach based on GlobalSCREEN, an industrial Java SCADA. The aim of this integrated development environment is to give SOLEIL's scientific and technical staff a way to develop GUI (Graphical User Interface) applications for external users of beamlines. These GUI applications must address the two following needs: monitoring and supervision of a control system and development and execution of automated processes (as beamline alignment, data collection and on-line data analysis). The first need is now completely answered through a rich set of Java graphical components based on the COMETE library and providing a high level of service for data logging, scanning and so on. To reach the same quality of service for process automation, a big effort has been made for more seamless integration of PASSERELLE, a work-flow engine with dedicated user-friendly interfaces for end users, packaged as JavaBeans in GlobalSCREEN components library. Starting with brief descriptions of software architecture of the PASSERELLE and GlobalSCREEN environments, we will then present the overall system integration design as well as the current status of deployment on SOLEIL beamlines. (authors)

High-brightness electron beams for production of high intensity, coherent radiation for scientific and industrial applications

International Nuclear Information System (INIS)

Kim, K.-J.

1999-01-01

Relativistic electron beams with high six-dimensional phase space densities, i.e., high-brightness beams, are the basis for efficient generation of intense and coherent radiation beams for advanced scientific and industrial applications. The remarkable progress in synchrotrons radiation facilities from the first generation to the current, third-generation capability illustrates this point. With the recent development of the high-brightness electron gun based on laser-driven rf photocathodes, linacs have become another important option for high-brightness electron beams. With linacs of about 100 MeV, megawatt-class infrared free-electron lasers can be designed for industrial applications such as power beaming. With linacs of about 10 GeV, 1- angstrom x-ray beams with brightness and time resolution exceeding by several orders of magnitude the current synchrotrons radiation sources can be generated based on self-amplified spontaneous emission. Scattering of a high-brightness electron beam by high power laser beams is emerging as a compact method of generating short-pulse, bright x-rays. In the high-energy frontier, photons of TeV quantum energy could be generated by scattering laser beams with TeV electron beams in future linear colliders

Ontology-Driven Discovery of Scientific Computational Entities

Science.gov (United States)

Brazier, Pearl W.

2010-01-01

Many geoscientists use modern computational resources, such as software applications, Web services, scientific workflows and datasets that are readily available on the Internet, to support their research and many common tasks. These resources are often shared via human contact and sometimes stored in data portals; however, they are not necessarily…

High historical values of foEs—Reality or artefact?

Science.gov (United States)

Laštovička, J.; Boška, J.; Burešová, D.; Kouba, D.

2012-01-01

Very high values of foEs had sometimes been reported in the past. These values, as well as all other ionogram-scaled values, had been derived from ionograms under the assumption of the vertical reflection of ordinary mode of sounding radio waves. In the past it was impossible to check the validity of this assumption. However, modern digisondes determine clearly the oblique or extraordinary mode reflections. To test the assumption of the vertical reflection of ordinary mode for high values of foEs, seven summers (June 2004-August 2010) from a midlatitude station Pruhonice are chosen. All hourly values of foEs≥6.0 MHz are selected from this data set, altogether 282 values. In 90% of cases the “classical” way of evaluation of foEs provides values higher than “true” values from modern digisonde (average difference about 1 MHz). 38% of “classical” foEs are oblique reflections, which however do not occur in direction perpendicular to geomagnetic field. The occurrence of high values of foEs varies very much from year to year between 0 and 130 events per year. As for diurnal variation, a pronounced maximum occurs at ˜10:00LT and 16:00LT (secondary), and a minimum after midnight.

Scientific and Technological Report 2004; Informe Cientifico Tecnologico 2004

Energy Technology Data Exchange (ETDEWEB)

Prado Cuba, Antonio; Robles Nique, Anita; Solis Veliz, Jose; Rodriguez R, Juan [eds.

2005-08-15

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2004. This report includes 48 papers divided in 6 subject matters, such as: materials science, nuclear engineering, industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects.

Performance Evaluation of an Intel Haswell- and Ivy Bridge-Based Supercomputer Using Scientific and Engineering Applications

Science.gov (United States)

Saini, Subhash; Hood, Robert T.; Chang, Johnny; Baron, John

2016-01-01

We present a performance evaluation conducted on a production supercomputer of the Intel Xeon Processor E5- 2680v3, a twelve-core implementation of the fourth-generation Haswell architecture, and compare it with Intel Xeon Processor E5-2680v2, an Ivy Bridge implementation of the third-generation Sandy Bridge architecture. Several new architectural features have been incorporated in Haswell including improvements in all levels of the memory hierarchy as well as improvements to vector instructions and power management. We critically evaluate these new features of Haswell and compare with Ivy Bridge using several low-level benchmarks including subset of HPCC, HPCG and four full-scale scientific and engineering applications. We also present a model to predict the performance of HPCG and Cart3D within 5%, and Overflow within 10% accuracy.

New developments in laser-based photoemission spectroscopy and its scientific applications: a key issues review

Science.gov (United States)

Zhou, Xingjiang; He, Shaolong; Liu, Guodong; Zhao, Lin; Yu, Li; Zhang, Wentao

2018-06-01

The significant progress in angle-resolved photoemission spectroscopy (ARPES) in last three decades has elevated it from a traditional band mapping tool to a precise probe of many-body interactions and dynamics of quasiparticles in complex quantum systems. The recent developments of deep ultraviolet (DUV, including ultraviolet and vacuum ultraviolet) laser-based ARPES have further pushed this technique to a new level. In this paper, we review some latest developments in DUV laser-based photoemission systems, including the super-high energy and momentum resolution ARPES, the spin-resolved ARPES, the time-of-flight ARPES, and the time-resolved ARPES. We also highlight some scientific applications in the study of electronic structure in unconventional superconductors and topological materials using these state-of-the-art DUV laser-based ARPES. Finally we provide our perspectives on the future directions in the development of laser-based photoemission systems.

77 FR 40358 - Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM)

Science.gov (United States)

2012-07-09

..., revised, and alternative safety testing methods with regulatory applicability and promotes the scientific... DEPARTMENT OF HEALTH AND HUMAN SERVICES Meeting of the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM) AGENCY: Division of the National Toxicology Program (DNTP...

Design and Application of Sensors for Chemical Cytometry.

Science.gov (United States)

Vickerman, Brianna M; Anttila, Matthew M; Petersen, Brae V; Allbritton, Nancy L; Lawrence, David S

2018-02-08

The bulk cell population response to a stimulus, be it a growth factor or a cytotoxic agent, neglects the cell-to-cell variability that can serve as a friend or as a foe in human biology. Biochemical variations among closely related cells furnish the basis for the adaptability of the immune system but also act as the root cause of resistance to chemotherapy by tumors. Consequently, the ability to probe for the presence of key biochemical variables at the single-cell level is now recognized to be of significant biological and biomedical impact. Chemical cytometry has emerged as an ultrasensitive single-cell platform with the flexibility to measure an array of cellular components, ranging from metabolite concentrations to enzyme activities. We briefly review the various chemical cytometry strategies, including recent advances in reporter design, probe and metabolite separation, and detection instrumentation. We also describe strategies for improving intracellular delivery, biochemical specificity, metabolic stability, and detection sensitivity of probes. Recent applications of these strategies to small molecules, lipids, proteins, and other analytes are discussed. Finally, we assess the current scope and limitations of chemical cytometry and discuss areas for future development to meet the needs of single-cell research.

Natural products-friends or foes?

Science.gov (United States)

Margină, Denisa; Ilie, Mihaela; Grădinaru, Daniela; Androutsopoulos, Vasilis P; Kouretas, Demetrios; Tsatsakis, Aristidis M

2015-08-05

A trend in the general population has been observed in recent years regarding the orientation toward preventive measures in health; in this context the increased interest from the users and researchers concerning the active effect of food supplements on the health state and on longevity, is noticeable. All over the world, the consumption of natural foods and of vegetal supplements has increased spectacularly over the last 5-10 years. The decreased prevalence of cardio-vascular diseases associated with Mediterranean diet, as well as the French paradox convinced researchers to scientifically document the beneficial outcomes pointed out by traditional use of plants, and to try to develop supplements that would have the same positive effects as these noticed for diet components. The intense research dedicated to this topic revealed the fact that food supplements are linked to some problematic aspects, such as toxicological side effects when associated with classical synthetic drugs. The food supplement-drug interactions are submitted to complex issues regarding pharmacokinetic interactions leading to changes in absorption, distribution, metabolism and excretion processes with direct impact on effect and toxicological potential. The present review based on recent literature aims at discussing the food-drug interactions with direct impact on efficacy and toxicity of drugs. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Food industry: friend or foe?

Science.gov (United States)

Yach, D

2014-01-01

Open discourse and tolerance between the food industry and public sector is limited. As a result, the public and private sectors are reluctant to collaborate on pressing nutritional issues. Those in the public sector have never heard what they could do to encourage a food company's transition towards healthier foods and beverages, whereas many in the private sector dismissed policies and actions initiated within the public sector. During my career, I have sought to engage the broadest possible stakeholder groups required to develop evidence-based policies and with the aim of improving public health. My recent experience in industry confirmed my view about the need for scientific exchange regardless of the disagreements about policy. Open discourse and partnering is essential if we are to tackle complex food and health issues and improve the global food system. Private-public engagement can provide faster and more sustainable results than government alone without impacting profits. Moreover, a high-quality product in smaller portions will have higher profit margins than a bargain-sized product of lower quality. The food industry and private sector must come together to implement innovative strategies to address urgent nutritional needs. © 2013 The Author. obesity reviews © 2013 International Association for the Study of Obesity.

Using the Scientific Method to Engage Mathematical Modeling: An Investigation of pi

Science.gov (United States)

Archer, Lester A. C.; Ng, Karen E.

2016-01-01

The purpose of this paper is to explain how to use the scientific method as the framework to introduce mathematical model. Two interdisciplinary activities, targeted for students in grade 6 or grade 7, are explained to show the application of the scientific method while building a mathematical model to investigate the relationship between the…

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

Energy Technology Data Exchange (ETDEWEB)

Fraser, Hamish L. [The Ohio State University (United States); Smith, David J., E-mail: david.smith@asu.edu [Arizona State University (United States); Wittig, James E. [Vanderbilt University (United States)

2017-05-15

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights.

The scientific careers of Robert Sinclair and Nestor Zaluzec - A brief sketch

International Nuclear Information System (INIS)

Fraser, Hamish L.; Smith, David J.; Wittig, James E.

2017-01-01

Robert (Bob) Sinclair and Nestor Zaluzec have been working for many years at the leading edge of developments in electron microscopy techniques and applications. Their distinguished careers and some of their notable scientific achievements are briefly highlighted. - Highlights: • Biographical sketch of Bob Sinclair • Biographical Sketch of Nestor Zaluzec • Scientific career highlights

Scientific development of smart farming technologies and their application in Brazil

Directory of Open Access Journals (Sweden)

Dieisson Pivoto

2018-03-01

Full Text Available Smart farming (SF involves the incorporation of information and communication technologies into machinery, equipment, and sensors for use in agricultural production systems. New technologies such as the internet of things and cloud computing are expected to advance this development, introducing more robots and artificial intelligence into farming. Therefore, the aims of this paper are twofold: (i to characterize the scientific knowledge about SF that is available in the worldwide scientific literature based on the main factors of development by country and over time and (ii to describe current SF prospects in Brazil from the perspective of experts in this field. The research involved conducting semi-structured interviews with market and researcher experts in Brazil and using a bibliometric survey by means of data mining software. Integration between the different available systems on the market was identified as one of the main limiting factors to SF evolution. Another limiting factor is the education, ability, and skills of farmers to understand and handle SF tools. These limitations revealed a market opportunity for enterprises to explore and help solve these problems, and science can contribute to this process. China, the United States, South Korea, Germany, and Japan contribute the largest number of scientific studies to the field. Countries that invest more in R&D generate the most publications; this could indicate which countries will be leaders in smart farming. The use of both research methods in a complementary manner allowed to understand how science frame the SF and the mains barriers to adopt it in Brazil.

Math Garden: A new educational and scientific instrument

NARCIS (Netherlands)

Straatemeier, M.

2014-01-01

This dissertation describes the research concerning the construction of a new educational and scientific instrument. This instrument, Math Garden, is a web application in which children can practice arithmetic by playing math games in which items are tailored to their ability level. At the same

Customer Relationship Management in scientific and research institutions

Directory of Open Access Journals (Sweden)

Jaromir Matulewicz

2013-12-01

Full Text Available Basing on the example of a scientific institute, this article shows: – potential areas in which CRM philosophy, procedures and tools could be applied – purpose of applying CRM – outcomes to expect from CRM application The article shows the Customer Relationship Management idea exclusively, along with areas of its use in scientific and research institutions and also a proposal to determine a group of clients for these institutions. The summary of the article consists of information regarding sources of knowledge about CRM philosophy and procedures (mainly bibliographical and also about IT systems which support CRM.

Extensional scientific realism vs. intensional scientific realism.

Science.gov (United States)

Park, Seungbae

2016-10-01

Extensional scientific realism is the view that each believable scientific theory is supported by the unique first-order evidence for it and that if we want to believe that it is true, we should rely on its unique first-order evidence. In contrast, intensional scientific realism is the view that all believable scientific theories have a common feature and that we should rely on it to determine whether a theory is believable or not. Fitzpatrick argues that extensional realism is immune, while intensional realism is not, to the pessimistic induction. I reply that if extensional realism overcomes the pessimistic induction at all, that is because it implicitly relies on the theoretical resource of intensional realism. I also argue that extensional realism, by nature, cannot embed a criterion for distinguishing between believable and unbelievable theories. Copyright © 2016 Elsevier Ltd. All rights reserved.

75 FR 32955 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-06-10

... evaluate grant applications. Place: Ritz Carlton Hotel, 1150 22nd Street, NW., Washington, DC 20037... grant applications. Place: Ritz-Carlton Hotel, 1150 22nd Street, NW., Boardroom, Washington, DC 20037... Hotel, 701 North Michigan Avenue, Chicago, IL 60611. Contact Person: Biao Tian, PhD, Scientific Review...

75 FR 65020 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-10-21

.... Agenda: To review and evaluate grant applications. Place: The Ritz-Carlton Hotel, 1150 22nd Street, NW...: To review and evaluate grant applications. Place: InterContinental Mark Hopkins Hotel, 999 California... Hotel, 999 Ninth Street, NW., Washington, DC 20001. Contact Person: Weijia Ni, PhD, Scientific Review...

77 FR 21158 - VA Directive 0005 on Scientific Integrity: Availability for Review and Comment

Science.gov (United States)

2012-04-09

... Draft VA Directive 0005 on Scientific Integrity: [square] Fosters a culture of transparency, integrity, and ethical behavior in the development and application of scientific and technological findings in VA... information from inappropriate political or commercial influence; [square] Ensures that selection and...

Scientific and Technological Report 2005; Informe Cientifico Tecnologico 2005

Energy Technology Data Exchange (ETDEWEB)

Prado Cuba, Antonio; Robles Nique, Anita; Rodriguez R, Juan; Solis Veliz, Jose [eds.

2006-07-15

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2005. This report includes 38 papers divided in 7 subject matters, such as: physics and chemistry, materials science, nuclear engineering, industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects.

Introduction to the LaRC central scientific computing complex

Science.gov (United States)

Shoosmith, John N.

1993-01-01

The computers and associated equipment that make up the Central Scientific Computing Complex of the Langley Research Center are briefly described. The electronic networks that provide access to the various components of the complex and a number of areas that can be used by Langley and contractors staff for special applications (scientific visualization, image processing, software engineering, and grid generation) are also described. Flight simulation facilities that use the central computers are described. Management of the complex, procedures for its use, and available services and resources are discussed. This document is intended for new users of the complex, for current users who wish to keep appraised of changes, and for visitors who need to understand the role of central scientific computers at Langley.

Method of Factor Extraction and Simple Structure of Data from Diverse Scientific Areas.

Science.gov (United States)

Thorndike, Robert M.

To study the applicability of simple structure logic for factorial data from scientific disciplines outside psychology, four correlation matrices from each of six scientific areas were factor analyzed by five factoring methods. Resulting factor matrices were compared on two objective criteria of simple structure before and after rotation.…

SCIENTIFIC AND INNOVATION ACTIVITIES OF HIGHER EDUCATION INSTITUTION: THE ESSENCE AND INTERACTION OF THE COMPONENTS

OpenAIRE

Meniailo, Viktorija

2017-01-01

One of the main directions of state policy in education is the development of scientific and innovation activities at institutions of higher education. It imposes on them additional features related to the inclusion of scientific activities in universities united innovative process for the creating and practical application of new knowledge. The purpose of the article is to establish the relationship between scientific and innovation activities and clarify the essence of scientific and innova...

Simulating experiments using a Comsol application for teaching scientific research methods

NARCIS (Netherlands)

Schijndel, van A.W.M.

2015-01-01

For universities it is important to teach the principles of scientific methods as soon as possible. However, in case of performing experiments, students need to have some knowledge and skills before start doing measurements. In this case, Comsol can be helpfully by simulating the experiments before

Founding editorial--forensics and TheScientificWorld.

Science.gov (United States)

Rowe, W

2001-10-30

At the beginning of a new millennium it seems a good idea to stop for a moment and take stock of the current state of forensic science. As a field of scientific research and scientific application, forensic science is a little more than a century old. Forensic science may be said to have begun in 1887 with the simultaneous publication of A. Conan Doyle's A Study in Scarlet and Hans Gross's Handbuch f1/4r Untersuchungsrichter. Conan Doyle's novel introduced to the world the character of Sherlock Holmes, whose literary career would popularize the use of physical evidence in criminal investigations. Gross's manual for examining magistrates suggests ways in which the expertise of chemists, biologists, geologists, and other natural scientists could contribute to investigations. Gross's book was translated into a number of languages and went through various updated editions during the course of the century. The intervening century saw the development and application of fingerprinting, firearm and tool mark identification, forensic chemistry, forensic biology, forensic toxicology, forensic odontology, forensic pathology, and forensic engineering. Increasingly, the judicial systems of the industrial nations of the world have come to rely upon the expertise of scientists in a variety of disciplines. In most advanced countries, virtually all criminal prosecutions now involve the presentation of scientific testimony. This has had the beneficial effect of diminishing the reliance of courts on eyewitness testimony and defendant confessions.

G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment.

Science.gov (United States)

Sun, Wei; Li, Lian; Yang, Qingqing; Shan, Wei; Zhang, Zhirong; Huang, Yuan

2015-11-02

Galectin-3 is overexpressed by numerous carcinomas and is a potential target for active tumor treatments. On the other hand, galectin-3 also plays a key role in cancer progression and prevents cells from undergoing apoptosis, thereby offsetting the benefits of active targeting drugs. However, the relative contribution of the protective antiapoptotic effects of galectin-3 and the proapoptotic effects of galectin-3-targeted therapies has remained yet unrevealed. Here, we show that a galectin-3-binding peptide G3-C12 could reverse galectin-3 from foe to friend for active targeting delivery system. Results showed G3-C12 modified N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin conjugates (G3-C12-HPMA-Dox) could internalize into galectin-3 overexpressed PC-3 cells via a highly specific ligand-receptor pathway (2.2 times higher cellular internalization than HPMA-Dox). The internalized Dox stimulated the translocation of galectin-3 to the mitochondria to prevent from apoptosis. In turn, this caused G3-C12-HPMA-Dox to concentrate into the mitochondria after binding to galectin-3 intracellularly. Initially, mitochondrial galectin-3 weakened Dox-induced mitochondrial damage; however, as time progressed, G3-C12 active-mediation allowed increasing amounts of Dox to be delivered to the mitochondria, which eventually induced higher level of apoptosis than nontargeted copolymers. In addition, G3-C12 downregulates galectin-3 expression, 0.43 times lower than control cells, which could possibly be responsible for the suppressed cell migration. Thus, G3-C12 peptide exerts sequential targeting to both cell membrane and mitochondria via regulating galectin-3, and eventually reverses and overcomes the protective effects of galectin-3; therefore, it could be a promising agent for the treatment of galectin-3-overexpressing cancers.

Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells.

Science.gov (United States)

Dafre, A L; Goldberg, J; Wang, T; Spiegel, D A; Maher, P

2015-12-01

Methylglyoxal (MGO) is a major glycating agent that reacts with basic residues of proteins and promotes the formation of advanced glycation end products (AGEs) which are believed to play key roles in a number of pathologies, such as diabetes, Alzheimer's disease, and inflammation. Here, we examined the effects of MGO on immortalized mouse hippocampal HT22 nerve cells. The endpoints analyzed were MGO and thiol status, the glyoxalase system, comprising glyoxalase 1 and 2 (GLO1/2), and the cytosolic and mitochondrial Trx/TrxR systems, as well as nuclear Nrf2 and its target genes. We found that nuclear Nrf2 is induced by MGO treatment in HT22 cells, as corroborated by induction of the Nrf2-controlled target genes and proteins glutamate cysteine ligase and heme oxygenase 1. Nrf2 knockdown prevented MGO-dependent induction of glutamate cysteine ligase and heme oxygenase 1. The cystine/glutamate antiporter, system xc(-), which is also controlled by Nrf2, was also induced. The increased cystine import (system xc(-)) activity and GCL expression promoted GSH synthesis, leading to increased levels of GSH. The data indicate that MGO can act as both a foe and a friend of the glyoxalase and the Trx/TrxR systems. At low concentrations of MGO (0.3mM), GLO2 is strongly induced, but at high MGO (0.75 mM) concentrations, GLO1 is inhibited and GLO2 is downregulated. The cytosolic Trx/TrxR system is impaired by MGO, where Trx is downregulated yet TrxR is induced, but strong MGO-dependent glycation may explain the loss in TrxR activity. We propose that Nrf2 can be the unifying element to explain the observed upregulation of GSH, GCL, HO1, TrxR1, Trx2, TrxR2, and system xc(-) system activity. Copyright © 2015. Published by Elsevier Inc.

75 FR 26262 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-05-11

... evaluate grant applications. Place: Little America Hotel, 500 South Main Street, Salt Lake City, UT 84101....m. Agenda: To review and evaluate grant applications. Place: Little America Hotel, 500 South Main Street, Salt Lake City, UT 84101. Contact Person: Xiang-Ning Li, MD, PhD, Scientific Review Officer...

Progress of scientific researches and project of CSR in IMP

International Nuclear Information System (INIS)

Jin Genming

2004-01-01

The article reviews the recent progress of the scientific researches including synthesis of new nuclides, investigations of the isospin effects in heavy ion collisions, studies of the nuclear structure in high spin states and the applications of heavy ion beams to other scientific researches, such as biology and material science. It also gives a brief introduction of the development of the design and progress of the new project of heavy ion cooling storage ring (CSR) of Lanzhou. (author)

EFFECT SCIENTIFIC INQUIRY TEACHING MODELS AND SCIENTIFIC ATTITUDE TO PHYSICS STUDENT OUTCOMES

Directory of Open Access Journals (Sweden)

Dian Clara Natalia Sihotang

2014-12-01

Full Text Available The objectives of this study were to determine whether: (1 the student’s achievement taught by using Scientific Inquiry Teaching Models is better than that of taught by using Direct Instruction; (2 the student’s achievement who have a high scientific attitude is better than student who have low scientific attitude; and (3 there is interaction between Scientific Inquiry Teaching Models and scientific attitude for the student’s achievement. The results of research are: (1 the student’s achievement given learning through Scientific Inquiry Teaching Models better than Direct Instruction; (2 the student’s achievement who have a high scientific attitude better than student who have low scientific attitude; and (3 there was interaction between Scientific Inquiry Teaching Models and scientific attitude for student’s achievement which this models is better to apply for student who have a high scientific attitude.

FAA Air Traffic Control Operations Concepts. Volume 5. ATCT/TCCC (airport Traffic Control Tower/Tower Control Computer Complex) Tower Controllers

Science.gov (United States)

1988-07-29

Departure List. T1.1.4.13 RESEQUENCE FOE MANUALLY 3.7.2.2.1.1.2.2-00 ARRIVAL LIST 457 3.7.2.2.1,1.2.2-11 b. Ordering - In manual ordering , the 457 a...3.7.2.2.1.1.2.3-12 b. Ordering - In manual ordering , the 457 controller shall have the capability to put a new FOE in the appropriate place in a sublist...3.7.2.2.1.1.2.2-00 ARRIVAL LIST 457 3.7.2.2.1.1.2.2-11 b. Ordering - In manual ordering , the 457 controller snall have the capability to put a new FOE in

Measuring the development of a common scientific lexicon in nanotechnology

Science.gov (United States)

Arora, Sanjay K.; Youtie, Jan; Carley, Stephen; Porter, Alan L.; Shapira, Philip

2014-01-01

Over the last two decades, nanotechnology has not only grown considerably but also evolved in its use of scientific terminology. This paper examines the growth in nano-prefixed terms in a corpus of nanotechnology scholarly publications over a 21-year time period. The percentage of publications using a nano-prefixed term has increased from nanotechnology papers oriented toward biomedical and clinical medicine applications has risen from just over 5 % to more than 11 %. While these results cannot fully distinguish between the use of nano-prefixed terms in response to broader policy or societal influences, they do suggest that there are intellectual and scientific underpinnings to the growth of a collectively shared vocabulary. We consider whether our findings signify the maturation of a scientific field and the extent to which this denotes the emergence of a shared scientific understanding regarding nanotechnology.

The methodological foundations of mutual integration of scientific knowledge in the field of physical education and sports and related sciences.

Directory of Open Access Journals (Sweden)

Kozina Zh.L.

2012-02-01

Full Text Available Possibilities of application of scientific knowledge in physical education and sport in contiguous scientific directions are considered. The advanced studies of leading specialists in area of physical education and sport are analysed. It is rotined that on the modern stage scientific developments in area of physical education and sport attained a level, when can be utillized in fundamental and applied sciences. Scientific researches in area of physical education and sport to the application scientific areas, such as pedagogics, psychology, design, programming et al are related. One of examples of mutual integration of scientific knowledge in area of physical education and sport there is theoretical conception of individualization of preparation of sportsmen.

The interaction between stratospheric monthly mean regional winds and sporadic-E

International Nuclear Information System (INIS)

Çetin, Kenan; Korlaelçi, Serhat; Özcan, Osman

2017-01-01

In the present study, a statistical investigation is carried out to explore whether there is a relationship between the critical frequency (foEs) of the sporadic-E layer that is occasionally seen on the E region of the ionosphere and the quasi-biennial oscillation (QBO) that flows in the east–west direction in the equatorial stratosphere. Multiple regression model as a statistical tool was used to determine the relationship between variables. In this model, the stationarity of the variables (foEs and QBO) was firstly analyzed for each station (Cocos Island, Gibilmanna, Niue Island, and Tahiti). Then, a co-integration test was made to determine the existence of a long-term relationship between QBO and foEs. After verifying the presence of a long-term relationship between the variables, the magnitude of the relationship between variables was further determined using the multiple regression model. As a result, it is concluded that the variations in foEs were explainable with QBO measured at 10 hPa altitude at the rate of 69%, 94%, 79%, and 58% for Cocos Island, Gibilmanna, Niue Island, and Tahiti stations, respectively. It is observed that the variations in foEs were explainable with QBO measured at 70 hPa altitude at the rate of 66%, 69%, 53%, and 47% for Cocos Island, Gibilmanna, Niue Island, and Tahiti stations, respectively. (paper)

Open-Source 3-D Platform for Low-Cost Scientific Instrument Ecosystem.

Science.gov (United States)

Zhang, C; Wijnen, B; Pearce, J M

2016-08-01

The combination of open-source software and hardware provides technically feasible methods to create low-cost, highly customized scientific research equipment. Open-source 3-D printers have proven useful for fabricating scientific tools. Here the capabilities of an open-source 3-D printer are expanded to become a highly flexible scientific platform. An automated low-cost 3-D motion control platform is presented that has the capacity to perform scientific applications, including (1) 3-D printing of scientific hardware; (2) laboratory auto-stirring, measuring, and probing; (3) automated fluid handling; and (4) shaking and mixing. The open-source 3-D platform not only facilities routine research while radically reducing the cost, but also inspires the creation of a diverse array of custom instruments that can be shared and replicated digitally throughout the world to drive down the cost of research and education further. © 2016 Society for Laboratory Automation and Screening.

GENERAL MECHANISMS OF CITATION SYSTEM OF SCIENTIFIC ARTICLES

Directory of Open Access Journals (Sweden)

Віктор Дмитрович ГОГУНСЬКИЙ

2016-02-01

Full Text Available Transformation competitive environment of higher education in the creation of effective mechanisms of management research encourages research teams and individual researchers to analyze their activity Publication search methods for improvement of citations of scientific publications. The paper analyzed the life cycle of scientific publications and show that the way to promote scientific articles in the world community inherent properties of Markov processes. Application of Markov chains allows top ground the need for active participation of the authors in the distribution of its publications in different scientometric databases, repositories of scientific and social networks. Markov model to describe decomposition of scientists made certain discrete states and proposed a schematic diagram of transitions between them. The model's 5A fully reflect the properties of the system. Communication influences the probability of changing system states with consistent movement along the trajectory from a lack of information about the publication to familiarize with it because of the positive attitude to state its citation. This is a must as well as a negative attitude to the publications. Proved that improve performance citation of scientific publications in the case of using Google Scholar, ORCID, Mendeley, Academia, ResearchGate, and others. The active participation of authors in their publications available in these systems leads to an increase in the proportion of articles that are available to colleagues in the global scientific community that is becoming one of the factors of increase in citations.

Accelerating Scientific Applications using High Performance Dense and Sparse Linear Algebra Kernels on GPUs

KAUST Repository

Abdelfattah, Ahmad

2015-01-15

High performance computing (HPC) platforms are evolving to more heterogeneous configurations to support the workloads of various applications. The current hardware landscape is composed of traditional multicore CPUs equipped with hardware accelerators that can handle high levels of parallelism. Graphical Processing Units (GPUs) are popular high performance hardware accelerators in modern supercomputers. GPU programming has a different model than that for CPUs, which means that many numerical kernels have to be redesigned and optimized specifically for this architecture. GPUs usually outperform multicore CPUs in some compute intensive and massively parallel applications that have regular processing patterns. However, most scientific applications rely on crucial memory-bound kernels and may witness bottlenecks due to the overhead of the memory bus latency. They can still take advantage of the GPU compute power capabilities, provided that an efficient architecture-aware design is achieved. This dissertation presents a uniform design strategy for optimizing critical memory-bound kernels on GPUs. Based on hierarchical register blocking, double buffering and latency hiding techniques, this strategy leverages the performance of a wide range of standard numerical kernels found in dense and sparse linear algebra libraries. The work presented here focuses on matrix-vector multiplication kernels (MVM) as repre- sentative and most important memory-bound operations in this context. Each kernel inherits the benefits of the proposed strategies. By exposing a proper set of tuning parameters, the strategy is flexible enough to suit different types of matrices, ranging from large dense matrices, to sparse matrices with dense block structures, while high performance is maintained. Furthermore, the tuning parameters are used to maintain the relative performance across different GPU architectures. Multi-GPU acceleration is proposed to scale the performance on several devices. The

Comparison of scientific and administrative database management systems

Science.gov (United States)

Stoltzfus, J. C.

1983-01-01

Some characteristics found to be different for scientific and administrative data bases are identified and some of the corresponding generic requirements for data base management systems (DBMS) are discussed. The requirements discussed are especially stringent for either the scientific or administrative data bases. For some, no commercial DBMS is fully satisfactory, and the data base designer must invent a suitable approach. For others, commercial systems are available with elegant solutions, and a wrong choice would mean an expensive work-around to provide the missing features. It is concluded that selection of a DBMS must be based on the requirements for the information system. There is no unique distinction between scientific and administrative data bases or DBMS. The distinction comes from the logical structure of the data, and understanding the data and their relationships is the key to defining the requirements and selecting an appropriate DBMS for a given set of applications.

A Component Approach to Collaborative Scientific Software Development: Tools and Techniques Utilized by the Quantum Chemistry Science Application Partnership

Directory of Open Access Journals (Sweden)

Joseph P. Kenny

2008-01-01

Full Text Available Cutting-edge scientific computing software is complex, increasingly involving the coupling of multiple packages to combine advanced algorithms or simulations at multiple physical scales. Component-based software engineering (CBSE has been advanced as a technique for managing this complexity, and complex component applications have been created in the quantum chemistry domain, as well as several other simulation areas, using the component model advocated by the Common Component Architecture (CCA Forum. While programming models do indeed enable sound software engineering practices, the selection of programming model is just one building block in a comprehensive approach to large-scale collaborative development which must also address interface and data standardization, and language and package interoperability. We provide an overview of the development approach utilized within the Quantum Chemistry Science Application Partnership, identifying design challenges, describing the techniques which we have adopted to address these challenges and highlighting the advantages which the CCA approach offers for collaborative development.

Exploration of Korean Students' Scientific Imagination Using the Scientific Imagination Inventory

Science.gov (United States)

Mun, Jiyeong; Mun, Kongju; Kim, Sung-Won

2015-01-01

This article reports on the study of the components of scientific imagination and describes the scales used to measure scientific imagination in Korean elementary and secondary students. In this study, we developed an inventory, which we call the Scientific Imagination Inventory (SII), in order to examine aspects of scientific imagination. We…

[Scientific advice by the national and European approval authorities concerning advanced therapy medicinal products].

Science.gov (United States)

Jost, Nils; Schüssler-Lenz, Martina; Ziegele, Bettina; Reinhardt, Jens

2015-11-01

The aim of scientific advice is to support pharmaceutical developers in regulatory and scientific questions, thus facilitating the development of safe and efficacious new medicinal products. Recent years have shown that the development of advanced therapy medicinal products (ATMPs) in particular needs a high degree of regulatory support. On one hand, this is related to the complexity and heterogeneity of this group of medicinal products and on the other hand due to the fact that mainly academic research institutions and small- and medium-sized enterprises (SMEs) are developing ATMPs. These often have limited regulatory experience and resources. In 2009 the Paul-Ehrlich-Institut (PEI) initiated the Innovation Office as a contact point for applicants developing ATMPs. The mandate of the Innovation Office is to provide support on regulatory questions and to coordinate national scientific advice meetings concerning ATMPs for every phase in drug development and especially with view to the preparation of clinical trial applications. On the European level, the Scientific Advice Working Party (SAWP) of the Committee for Medicinal Products for Human Use (CHMP) of the European Medicinal Agency (EMA) offers scientific advice. This article describes the concepts of national and EMA scientific advice concerning ATMPs and summarizes the experience of the last six years.

Scientific support of nuclear energy in Bulgaria

International Nuclear Information System (INIS)

Stamenov, Y.; Ilieva, K.; Ruskov, T.

2002-01-01

Taking into consideration the scientific and technical potential of the Institute and actual for this country problems, yet 3-4 years ago the priority tasks with application character were clearly defined: Safety of nuclear energy; The problems of radioactive waste; Ecology: control and monitoring of environment; Information maintenance. Specialists of the INRNE have been studying various problems and tasks intended to the scientific support of nuclear energy, which are of crucial national significance with respect to ensuring a high level of safety, an optimization of processes and effectiveness of operation of the Kozloduy NPP. These are programmes, accomplished in narrow collaboration with domestic, foreign and International institutions. In this relation, the more substantial examples of programmes and tasks, carried out by the INRNE are pointed out

Application of scientific criteria to food allergens of public health importance.

Science.gov (United States)

Chung, Y J; Ronsmans, S; Crevel, R W R; Houben, G F; Rona, R J; Ward, R; Baka, A

2012-11-01

Scientific criteria for identifying allergenic foods of public health importance (Björkstén, B., Crevel, R., Hischenhuber, C., Løvik, M., Samuels, F., Strobel, S., Taylor, S.L., Wal, J.-M., Ward, R., 2008. Criteria for identifying allergenic foods of public health importance. Regulatory Toxicology and Pharmacology 51(1), 42-52) have been further refined to incorporate an assessment of the strength of available scientific evidence (van Bilsen, J.H., Ronsmans, S., Crevel, R.W., Rona, R.J., Przyrembel, H., Penninks, A.H., Contor, L., Houben, G.F., 2011. Evaluation of scientific criteria for identifying allergenic food of public health importance. Regulatory Toxicology and Pharmacology 60, 281-289). A multi-disciplinary group was invited to critically test the refined approach. They independently evaluated selected publications on coconut, soy and/or peanut allergy, scored them using the newly developed level of evidence criteria, and debated proposed approaches for combining and utilising the scores to measure the overall impact of an allergen in public health impact assessments. The evaluation of selected publications using the modified criteria produced a relatively consistent result across the experts. These refined criteria were judged to be a way forward for the identification of allergenic foods of public health importance, and for prioritisation of allergen risk management and future data gathering. The debate to combine available evidence when assessing whether an allergenic food is of sufficient public health importance to warrant active management led to proposals on how to weight and combine evidence on allergen severity, potency and prevalence. The refined criteria facilitate a debate to find a meaningful sequence of steps to summarise the available information in relation to a food allergen. Copyright © 2012 ILSI Europe. Published by Elsevier Inc. All rights reserved.

76 FR 50997 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2011-08-17

... DEPARTMENT OF COMMERCE International Trade Administration Application(s) for Duty-Free Entry of..., School of Earth Sciences, 275 Mendenhall Laboratory, 125 South Oval Mall, Columbus, OH 43210. Instrument... and high-contrast images, a stage that is easy to move, a focus that does not change with changing...

Featured Article: Genotation: Actionable knowledge for the scientific reader.

Science.gov (United States)

Nagahawatte, Panduka; Willis, Ethan; Sakauye, Mark; Jose, Rony; Chen, Hao; Davis, Robert L

2016-06-01

We present an article viewer application that allows a scientific reader to easily discover and share knowledge by linking genomics-related concepts to knowledge of disparate biomedical databases. High-throughput data streams generated by technical advancements have contributed to scientific knowledge discovery at an unprecedented rate. Biomedical Informaticists have created a diverse set of databases to store and retrieve the discovered knowledge. The diversity and abundance of such resources present biomedical researchers a challenge with knowledge discovery. These challenges highlight a need for a better informatics solution. We use a text mining algorithm, Genomine, to identify gene symbols from the text of a journal article. The identified symbols are supplemented with information from the GenoDB knowledgebase. Self-updating GenoDB contains information from NCBI Gene, Clinvar, Medgen, dbSNP, KEGG, PharmGKB, Uniprot, and Hugo Gene databases. The journal viewer is a web application accessible via a web browser. The features described herein are accessible on www.genotation.org The Genomine algorithm identifies gene symbols with an accuracy shown by .65 F-Score. GenoDB currently contains information regarding 59,905 gene symbols, 5633 drug-gene relationships, 5981 gene-disease relationships, and 713 pathways. This application provides scientific readers with actionable knowledge related to concepts of a manuscript. The reader will be able to save and share supplements to be visualized in a graphical manner. This provides convenient access to details of complex biological phenomena, enabling biomedical researchers to generate novel hypothesis to further our knowledge in human health. This manuscript presents a novel application that integrates genomic, proteomic, and pharmacogenomic information to supplement content of a biomedical manuscript and enable readers to automatically discover actionable knowledge. © 2016 by the Society for Experimental Biology and

Tungsten or Wolfram: Friend or Foe?

Science.gov (United States)

Zoroddu, Maria A; Medici, Serenella; Peana, Massimiliano; Nurchi, Valeria M; Lachowicz, Joanna I; Laulicht-Glickc, Freda; Costa, Max

2018-01-01

Tungsten or wolfram was regarded for many years as an enemy within the tin smelting and mining industry, because it conferred impurity or dirtiness in tin mining. However, later it was considered an amazing metal for its strength and flexibility, together with its diamond like hardness and its melting point which is the highest of any metal. It was first believed to be relatively inert and an only slightly toxic metal. Since early 2000, the risk exerted by tungsten alloys, its dusts and particulates to induce cancer and several other adverse effects in animals as well as humans has been highlighted from in vitro and in vivo experiments. Thus, it becomes necessary to take a careful look at all the most recent data reported in the scientific literature, covering the years 2001-2016. In fact, the findings indicate that much more attention should be devoted to thoroughly investigate the toxic effects of tungsten and the involved mechanisms of tungsten metal or tungsten metal ions. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Commissioning of Temelin NPP as seen by scientific supervisory group

International Nuclear Information System (INIS)

Svoboda, C.

2003-01-01

Scientific Supervisory Group worked during the Temelin NPP commissioning process as an independent supervisor. The main tasks and main results of its activity are described in this contribution. The characteristic common features of commissioning process and most important events from the Scientific Supervisory Group point of view are presented. In April 1999 the Czech Power Utility with the objective to achieve maximum level of nuclear safety and quality within the NPP Temelin commissioning procedures has established a special body / Scientific Supervisory Group and requested Nuclear Research Institute Rez plc to perform the required function. The Scientific Supervisory Group proceeds in accordance with its Statute and provides an independent specialised professional and expert work focused on nuclear safety assurance, assesment of the selected documentation related to plant preparedness for the individual commissioning stages, and, of course. on assessment of the commissioning tests results. While performing its function the Scientific Supervisory Group is guided by the Atomic Act and the relevant Directives of State Office for Nuclear Safety; its activities are in compliance with the applicable IAEA recommendations (Authors)

Scientific activities 1977 and 1978

International Nuclear Information System (INIS)

1980-01-01

The scientific activities and achievements of the Nuclear Research Center Democritus for the years 1977 and 1978 are presented in the form of a list of 79 projects giving title, objectives, commencement year, responsible of each project and the pertaining lists of publications. The 14 chapters of this work cover the activities of the main Divisions of the Democritus NRC: Exploration of Radioactive Minerals, Computer Center, Environmental Radioactivity, Chemistry, Physics, Biology, Soil Science, Electronics, Reactor, Health Physics, Radioisotopes, Technological Applications and Medical Service. (T.A.)

Integrating multiple scientific computing needs via a Private Cloud infrastructure

International Nuclear Information System (INIS)

Bagnasco, S; Berzano, D; Brunetti, R; Lusso, S; Vallero, S

2014-01-01

In a typical scientific computing centre, diverse applications coexist and share a single physical infrastructure. An underlying Private Cloud facility eases the management and maintenance of heterogeneous use cases such as multipurpose or application-specific batch farms, Grid sites catering to different communities, parallel interactive data analysis facilities and others. It allows to dynamically and efficiently allocate resources to any application and to tailor the virtual machines according to the applications' requirements. Furthermore, the maintenance of large deployments of complex and rapidly evolving middleware and application software is eased by the use of virtual images and contextualization techniques; for example, rolling updates can be performed easily and minimizing the downtime. In this contribution we describe the Private Cloud infrastructure at the INFN-Torino Computer Centre, that hosts a full-fledged WLCG Tier-2 site and a dynamically expandable PROOF-based Interactive Analysis Facility for the ALICE experiment at the CERN LHC and several smaller scientific computing applications. The Private Cloud building blocks include the OpenNebula software stack, the GlusterFS filesystem (used in two different configurations for worker- and service-class hypervisors) and the OpenWRT Linux distribution (used for network virtualization). A future integration into a federated higher-level infrastructure is made possible by exposing commonly used APIs like EC2 and by using mainstream contextualization tools like CloudInit.

Scientific and Technological Report 2009; Informe Cientifico Tecnologico 2009

Energy Technology Data Exchange (ETDEWEB)

Prado Cuba, Antonio; Santiago Contreras, Julio; Lopez Milla, Alcides; Ramos Trujillo, Bertha (ed.), E-mail: aprado@ipen.gob.p [Instituto Peruano de Energia Nuclear, Lima (Peru)

2010-11-15

This annual scientific and technological report provides an overview of research and development activities at Peruvian Institute of Nuclear Energy (IPEN) during the period from 1 january to 31 december, 2009. This report includes 46 papers divided in 7 subject matters, such as: physics and chemistry, materials science, nuclear engineering, mining industrial and environmental applications, medical and biological applications, radiation protection and nuclear safety, and management aspects. It also includes annexes. (APC)

Making US Soil Taxonomy more scientifically applicable to environmental and food security issues.

Science.gov (United States)

Monger, Curtis; Lindbo, David L.; Wysocki, Doug; Schoeneberger, Phil; Libohova, Zamir

2017-04-01

US Department of Agriculture began mapping soils in the 1890s on a county-by-county basis until most of the conterminous United States was mapped by the late 1930s. This first-generation mapping was followed by a second-generation that re-mapped the US beginning in the 1940s. Soil classification during these periods evolved into the current system of Soil Taxonomy which is based on (1) soil features as natural phenomena and on (2) soil properties important for agriculture and other land uses. While this system has enabled communication among soil surveyors, the scientific applicability of Soil Taxonomy to address environmental and food security issues has been under-utilized. In particular, little effort has been exerted to understand how soil taxa interact and function together as larger units—as soil systems. Thus, much soil-geomorphic understanding that could be applied to process-based modeling remains unexploited. The challenge for soil taxonomists in the United States and elsewhere is to expand their expertise and work with modelers to explore how soil taxa are linked to each other, how they influence water, nutrient, and pollutant flow through the landscape, how they interact with ecology, and how they change with human land use.

Tunable solid-state laser technology for applications to scientific and technological experiments from space

Science.gov (United States)

Allario, F.; Taylor, L. V.

1986-01-01

Current plans for the Earth Observing System (EOS) include development of a lidar facility to conduct scientific experiments from a polar orbiting platforms. A recommended set of experiments were scoped, which includes techniques of atmospheric backscatter (Lidar), Differential Absorption Lidar (DIAL), altimetry, and retroranging. Preliminary assessments of the resources (power, weight, volume) required by the Eos Lidar Facility were conducted. A research program in tunable solid state laser technology was developed, which includes laser materials development, modeling and experiments on the physics of solid state laser materials, and development of solid state laser transmitters with a strong focus on Eos scientific investigations. Some of the system studies that were conducted which highlight the payoff of solid state laser technology for the Eos scientific investigations will be discussed. Additionally, a summary of some promising research results which have recently emerged from the research program will be presented.

78 FR 59362 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-09-26

... Scientific Review Special Emphasis Panel, RFA-MD-13-005: Revision Applications for Basic Social and Behavioral Research on the Social, Cultural, Biological and Psychological Mechanisms of Stigma. Date: October...

Scientific computing and algorithms in industrial simulations projects and products of Fraunhofer SCAI

CERN Document Server

Schüller, Anton; Schweitzer, Marc

2017-01-01

The contributions gathered here provide an overview of current research projects and selected software products of the Fraunhofer Institute for Algorithms and Scientific Computing SCAI. They show the wide range of challenges that scientific computing currently faces, the solutions it offers, and its important role in developing applications for industry. Given the exciting field of applied collaborative research and development it discusses, the book will appeal to scientists, practitioners, and students alike. The Fraunhofer Institute for Algorithms and Scientific Computing SCAI combines excellent research and application-oriented development to provide added value for our partners. SCAI develops numerical techniques, parallel algorithms and specialized software tools to support and optimize industrial simulations. Moreover, it implements custom software solutions for production and logistics, and offers calculations on high-performance computers. Its services and products are based on state-of-the-art metho...

Language interoperability for high-performance parallel scientific components

International Nuclear Information System (INIS)

Elliot, N; Kohn, S; Smolinski, B

1999-01-01

With the increasing complexity and interdisciplinary nature of scientific applications, code reuse is becoming increasingly important in scientific computing. One method for facilitating code reuse is the use of components technologies, which have been used widely in industry. However, components have only recently worked their way into scientific computing. Language interoperability is an important underlying technology for these component architectures. In this paper, we present an approach to language interoperability for a high-performance parallel, component architecture being developed by the Common Component Architecture (CCA) group. Our approach is based on Interface Definition Language (IDL) techniques. We have developed a Scientific Interface Definition Language (SIDL), as well as bindings to C and Fortran. We have also developed a SIDL compiler and run-time library support for reference counting, reflection, object management, and exception handling (Babel). Results from using Babel to call a standard numerical solver library (written in C) from C and Fortran show that the cost of using Babel is minimal, where as the savings in development time and the benefits of object-oriented development support for C and Fortran far outweigh the costs

50 CFR 22.21 - What are the requirements concerning scientific and exhibition purpose permits?

Science.gov (United States)

2010-10-01

... purposes? (1) You must submit applications for permits to take, possess, or transport within the United... golden eagles, or their parts, nests, or eggs for the scientific or exhibition purposes of public museums, public scientific societies, or public zoological parks. We will not issue a permit under this section...

A New Hybrid Approach for Augmented Reality Maintenance in Scientific Facilities

Directory of Open Access Journals (Sweden)

Héctor Martínez

2013-09-01

Full Text Available Maintenance in scientific facilities is a difficult issue, especially in large and hazardous facilities, due to the complexity of tasks and equipment. Augmented reality is a technology that has already shown great promise in the maintenance field. With the help of augmented reality applications, maintenance tasks can be carried out faster and more safely. The problem with current applications is that they are small-scale prototypes that do not easily scale to large facility maintenance applications. This paper presents a new hybrid approach that enables the creation of augmented reality maintenance applications for large and hazardous scientific facilities. In this paper, a new augmented reality marker and the algorithm for its recognition is proposed. The performance of the algorithm is verified in three test cases, showing promising results in two of them. Improvements in robustness in the third test case in which the camera is moving quickly or when light conditions are extreme are subject to further studies. The proposed new approach will be integrated into an existing augmented reality maintenance system.

78 FR 3009 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-15

.... Agenda: To review and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali Way, Marina... North Charles Street, Baltimore, MD 21201. Contact Person: Dianne Hardy, Ph.D., Scientific Review...

Applications of combinatorial optimization

CERN Document Server

Paschos, Vangelis Th

2013-01-01

Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management. The three volumes of the Combinatorial Optimization series aims to cover a wide range of topics in this area. These topics also deal with fundamental notions and approaches as with several classical applications of combinatorial optimization. "Applications of Combinatorial Optimization" is presenting a certain number among the most common and well-known applications of Combinatorial Optimization.

76 FR 43694 - Center for Scientific Review; Notice of Closed Meeting

Science.gov (United States)

2011-07-21

... personal privacy. Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflicts: Cystic Fibrosis, Lung Fibrosis, and Lung Innate Immunity Applications. Date: August 8, 2011. Time: 9 a.m...

77 FR 30021 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2012-05-21

... North Michigan Avenue, Chicago, IL 60611. Contact Person: Toby Behar, Ph.D., Scientific Review Officer.... Agenda: To review and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali Way, Marina...

78 FR 36553 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-18

...: Revision applications for research on assessing the role of Stigma in HIV prevention and care. Date: [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel; Program Project...

Effects of Scaffolds and Scientific Reasoning Ability on Web-Based Scientific Inquiry

Science.gov (United States)

Wu, Hui-Ling; Weng, Hsiao-Lan; She, Hsiao-Ching

2016-01-01

This study examined how background knowledge, scientific reasoning ability, and various scaffolding forms influenced students' science knowledge and scientific inquiry achievements. The students participated in an online scientific inquiry program involving such activities as generating scientific questions and drawing evidence-based conclusions,…

IPEN Scientific and technical publications 1956-1981

International Nuclear Information System (INIS)

1983-01-01

The Instituto de Pesquisas Energeticas e Nucleares - IPEN (Energy Research Institute) from Sao Paulo, Brazil, was founded in 1956. Since its foundation, the main objectives of IPEN has been to undertake research and development into the peaceful uses of nuclear energy and to train scientific personnel to post-graduate level. The IPEN Scientific and Technical Publication - IPEN/SP, is a system developed at IPEN. Its purpose has been to generate a data base identifying the technical and scientific literature produced by IPEN staff members, published either in the Institute's series or in others brazilian and foreign publications. Documents cited in this jubilee edition include those in which IPEN staff members were authors or co-authors; document published by foreign research visitors while working at IPEN facilities; theses prepared by IPEN staff and reports in which IPEN is a corporate author. The IPEN technical publications reflect the main fields of research persuaded by the Institute, namely nuclear physics radiochemistry, chemical engineering, nuclear metallurgy and engineering and finally medical and industrial applications of radioisotopes. This present volume, published under the new title of IPEN - Scientific and Technical Publications, is a cumulative edition, to celebrate the 25th. anniversary of IPEN. In this jubilee edition, 1345 document published by IPEN staff are cited, following the main subject heading of INIS Subject Categories. (author)

Founding Editorial – Forensics and TheScientificWorld

Directory of Open Access Journals (Sweden)

Walter Rowe

2001-01-01

Full Text Available At the beginning of a new millennium it seems a good idea to stop for a moment and take stock of the current state of forensic science. As a field of scientific research and scientific application, forensic science is a little more than a century old. Forensic science may be said to have begun in 1887 with the simultaneous publication of A. Conan Doyle’s A Study in Scarlet and Hans Gross’s Handbuch für Untersuchungsrichter. Conan Doyle’s novel introduced to the world the character of Sherlock Holmes, whose literary career would popularize the use of physical evidence in criminal investigations. Gross’s manual for examining magistrates suggests ways in which the expertise of chemists, biologists, geologists, and other natural scientists could contribute to investigations. Gross’s book was translated into a number of languages and went through various updated editions during the course of the century. The intervening century saw the development and application of fingerprinting, firearm and tool mark identification, forensic chemistry, forensic biology, forensic toxicology, forensic odontology, forensic pathology, and forensic engineering. Increasingly, the judicial systems of the industrial nations of the world have come to rely upon the expertise of scientists in a variety of disciplines. In most advanced countries, virtually all criminal prosecutions now involve the presentation of scientific testimony. This has had the beneficial effect of diminishing the reliance of courts on eyewitness testimony and defendant confessions.

Grant Application Development, Submission, Review, & Award

Science.gov (United States)

This infographic shows the National Cancer Institute general timeline progression through Grant Application Development, Submission, Review, and Award Infographic. In the first month, Applicant prepares and submits Grant Application to Grants.gov in response to FOA. In month two, The Center for Scientific Review (CSR) assigns applications that fall under the category of R01s, etc. to a Scientific Review Group (SRG) or the CSR assigns applications that fall under the category of Program Projects and Center Grants to NCI Division of Extramural Activities (DEA). Months four through five: First-level review by Scientific Review Group (SRG) for Scientific Merit: SRG assigns Impact Scores. Month five Summary Sstatements are prepared and are available to NCI Program staff and applicants. Month six, second-level review by National Cancer Advisory board (NCAB) for NCI Funding determination begins. NCAB makes recommendation to NCI Director, NCI develops funding plan, Applications selected for Funding, “Paylists” forwarded to Office of Grant Administration (OGA). Month ten, Award Negotiations and Issuance: Award issued, Award received by Institution, and Investigator begins work. www.cancer.gov Icons made by Freepik from http://www.flaticon.com is licensed by CC BY3.0

Achievement in research on ion beam application under the scientific cooperation program with the Gesellschaft fuer schwerionenforschung mbH

Energy Technology Data Exchange (ETDEWEB)

Yoshida, Masaru; Maekawa, Yasunari (eds.) [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

2003-03-01

The Japan Atomic Energy Research Institute (JAERI) and the Gasellshaft fuer Schwerionenforshung mbH (GSI) signed a memorandum of 'Research and Development in the Field of Ion Beam Application' in January, 1991 and started the cooperative research program. The cooperation has been implemented by means of joint research between JAERI and GSI, exchange of scientific and technical experts, and providing mutual exchange of research materials as well as technical information. This report summarizes the cooperative research activities under the cooperative research program in the last 12 years. The list of publications and several articles relating to this cooperative research program are attached as an appendix. All the attached articles are reprinted with permission from the publishers. (author)

77 FR 8883 - Draft Guidance for Industry on Scientific Considerations in Demonstrating Biosimilarity to a...

Science.gov (United States)

2012-02-15

... reference product for the purpose of submitting a marketing application through an abbreviated licensure... submitting a marketing application through the abbreviated licensure pathway under section 351(k) of the... FDA will use to review applications for biosimilar products; and General scientific principles in...

Scientific developments of liquid crystal-based optical memory: a review

Science.gov (United States)

Prakash, Jai; Chandran, Achu; Biradar, Ashok M.

2017-01-01

The memory behavior in liquid crystals (LCs), although rarely observed, has made very significant headway over the past three decades since their discovery in nematic type LCs. It has gone from a mere scientific curiosity to application in variety of commodities. The memory element formed by numerous LCs have been protected by patents, and some commercialized, and used as compensation to non-volatile memory devices, and as memory in personal computers and digital cameras. They also have the low cost, large area, high speed, and high density memory needed for advanced computers and digital electronics. Short and long duration memory behavior for industrial applications have been obtained from several LC materials, and an LC memory with interesting features and applications has been demonstrated using numerous LCs. However, considerable challenges still exist in searching for highly efficient, stable, and long-lifespan materials and methods so that the development of useful memory devices is possible. This review focuses on the scientific and technological approach of fascinating applications of LC-based memory. We address the introduction, development status, novel design and engineering principles, and parameters of LC memory. We also address how the amalgamation of LCs could bring significant change/improvement in memory effects in the emerging field of nanotechnology, and the application of LC memory as the active component for futuristic and interesting memory devices.

Software engineering and automatic continuous verification of scientific software

Science.gov (United States)

Piggott, M. D.; Hill, J.; Farrell, P. E.; Kramer, S. C.; Wilson, C. R.; Ham, D.; Gorman, G. J.; Bond, T.

2011-12-01

Software engineering of scientific code is challenging for a number of reasons including pressure to publish and a lack of awareness of the pitfalls of software engineering by scientists. The Applied Modelling and Computation Group at Imperial College is a diverse group of researchers that employ best practice software engineering methods whilst developing open source scientific software. Our main code is Fluidity - a multi-purpose computational fluid dynamics (CFD) code that can be used for a wide range of scientific applications from earth-scale mantle convection, through basin-scale ocean dynamics, to laboratory-scale classic CFD problems, and is coupled to a number of other codes including nuclear radiation and solid modelling. Our software development infrastructure consists of a number of free tools that could be employed by any group that develops scientific code and has been developed over a number of years with many lessons learnt. A single code base is developed by over 30 people for which we use bazaar for revision control, making good use of the strong branching and merging capabilities. Using features of Canonical's Launchpad platform, such as code review, blueprints for designing features and bug reporting gives the group, partners and other Fluidity uers an easy-to-use platform to collaborate and allows the induction of new members of the group into an environment where software development forms a central part of their work. The code repositoriy are coupled to an automated test and verification system which performs over 20,000 tests, including unit tests, short regression tests, code verification and large parallel tests. Included in these tests are build tests on HPC systems, including local and UK National HPC services. The testing of code in this manner leads to a continuous verification process; not a discrete event performed once development has ceased. Much of the code verification is done via the "gold standard" of comparisons to analytical

Scientific Data Management (SDM) Center for Enabling Technologies. 2007-2012

Energy Technology Data Exchange (ETDEWEB)

Ludascher, Bertram [Univ. of California, Davis, CA (United States); Altintas, Ilkay [Univ. of California, San Diego, CA (United States)

2013-09-06

Over the past five years, our activities have both established Kepler as a viable scientific workflow environment and demonstrated its value across multiple science applications. We have published numerous peer-reviewed papers on the technologies highlighted in this short paper and have given Kepler tutorials at SC06,SC07,SC08,and SciDAC 2007. Our outreach activities have allowed scientists to learn best practices and better utilize Kepler to address their individual workflow problems. Our contributions to advancing the state-of-the-art in scientific workflows have focused on the following areas. Progress in each of these areas is described in subsequent sections. Workflow development. The development of a deeper understanding of scientific workflows "in the wild" and of the requirements for support tools that allow easy construction of complex scientific workflows; Generic workflow components and templates. The development of generic actors (i.e.workflow components and processes) which can be broadly applied to scientific problems; Provenance collection and analysis. The design of a flexible provenance collection and analysis infrastructure within the workflow environment; and, Workflow reliability and fault tolerance. The improvement of the reliability and fault-tolerance of workflow environments.

ISDMS, Inel Scientific Data Management System

International Nuclear Information System (INIS)

Bruestle, H.R.; Russell, K.D.; Snider, D.M.; Stewart, H.D.

1993-01-01

Description of program or function: The Idaho National Engineering Laboratory (INEL) Scientific Data Management System, ISDMS, is a generalized scientific data processing system designed to meet the needs of the various organizations at the INEL. It consists of a set of general and specific processors running under the control of an executive processor which serves as the interface between the system and the user. The data requirements at the INEL are primarily for times series analyses. Data acquired at various site facilities are processed on the central CDC CYBER computers. This processing includes: data conversion, data calibration, computed parameter calculations, time series plots, and sundry other applications. The data structure used in ISDMS is CWAF, a common word addressable format. A table driven command language serves as the ISDMS control language. Execution in both batch and interactive mode is possible. All commands and their input arguments are specified in free form. ISDMS is a modular system both at the top executive or MASTER level and in the independent lower or sub-level modules. ISDMS processors were designed and isolated according to their function. This release of ISDMS, identified as 1.3A by the developers, includes processors for data conversion and reformatting for applications programs (e.g. RELAP4), interactive and batch graphics, data analysis, data storage, and archival and development aids

Multidimensional Environmental Data Resource Brokering on Computational Grids and Scientific Clouds

Science.gov (United States)

Montella, Raffaele; Giunta, Giulio; Laccetti, Giuliano

Grid computing has widely evolved over the past years, and its capabilities have found their way even into business products and are no longer relegated to scientific applications. Today, grid computing technology is not restricted to a set of specific grid open source or industrial products, but rather it is comprised of a set of capabilities virtually within any kind of software to create shared and highly collaborative production environments. These environments are focused on computational (workload) capabilities and the integration of information (data) into those computational capabilities. An active grid computing application field is the fully virtualization of scientific instruments in order to increase their availability and decrease operational and maintaining costs. Computational and information grids allow to manage real-world objects in a service-oriented way using industrial world-spread standards.

Scientific integrity in Brazil.

Science.gov (United States)

Lins, Liliane; Carvalho, Fernando Martins

2014-09-01

This article focuses on scientific integrity and the identification of predisposing factors to scientific misconduct in Brazil. Brazilian scientific production has increased in the last ten years, but the quality of the articles has decreased. Pressure on researchers and students for increasing scientific production may contribute to scientific misconduct. Cases of misconduct in science have been recently denounced in the country. Brazil has important institutions for controlling ethical and safety aspects of human research, but there is a lack of specific offices to investigate suspected cases of misconduct and policies to deal with scientific dishonesty.

Pharmacological and Toxicological Profile of Harmane-β-Carboline Alkaloid: Friend or Foe.

Science.gov (United States)

Khan, Haroon; Patel, Seema; Kamal, Mohammad A

2017-01-01

The plant secondary metabolites have an outstanding therapeutic potential and success over the years. In fact, it is the foundation of numerous clinically used drugs. Similarly, these is a general perception that these products are inherent safety. However, such products might have toxic/unwanted lethal effects therefore, along with biological relevance, toxicological evaluation is equally important for clinical applications. Therefore, harmane- β-carboline alkaloid was investigated for both therapeutic and toxicological potential. The literature related to the therapeutic/toxicological effects of the alkaloid was searched using various scientific data bases including Google, ScienceDirect, PubMed, SpringerLink, ASC. The peer reviewed articles were only selected. The harmane-β-carboline alkaloid has shown several pharmacological activities such as antianxiety, antidepressant, antiplatelet, antidiabetic, acetylcholinesterase and myeloperoxidase inhibition, antioxidant, antiparasitic, hypotensive, morphine withdrawal syndrome alleviation, and antinociceptive effects. On the other hand, it exhibited tremorogenic effect, for a symptom of Parkinson's disease. Adverse effect of the alkaloid on learning and memory have also been observed. All together, it is, concluded in this review that harmane elicited marked pharmacological effects but simultaneously, it possessed some serious side effects that could be the primary hurdle in the way of its clinical testing. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Advanced Artificial Science. The development of an artificial science and engineering research infrastructure to facilitate innovative computational modeling, analysis, and application to interdisciplinary areas of scientific investigation.

Energy Technology Data Exchange (ETDEWEB)

Saffer, Shelley (Sam) I.

2014-12-01

This is a final report of the DOE award DE-SC0001132, Advanced Artificial Science. The development of an artificial science and engineering research infrastructure to facilitate innovative computational modeling, analysis, and application to interdisciplinary areas of scientific investigation. This document describes the achievements of the goals, and resulting research made possible by this award.

Performance Validity Testing in Neuropsychology: Scientific Basis and Clinical Application-A Brief Review.

Science.gov (United States)

Greher, Michael R; Wodushek, Thomas R

2017-03-01

Performance validity testing refers to neuropsychologists' methodology for determining whether neuropsychological test performances completed in the course of an evaluation are valid (ie, the results of true neurocognitive function) or invalid (ie, overly impacted by the patient's effort/engagement in testing). This determination relies upon the use of either standalone tests designed for this sole purpose, or specific scores/indicators embedded within traditional neuropsychological measures that have demonstrated this utility. In response to a greater appreciation for the critical role that performance validity issues play in neuropsychological testing and the need to measure this variable to the best of our ability, the scientific base for performance validity testing has expanded greatly over the last 20 to 30 years. As such, the majority of current day neuropsychologists in the United States use a variety of measures for the purpose of performance validity testing as part of everyday forensic and clinical practice and address this issue directly in their evaluations. The following is the first article of a 2-part series that will address the evolution of performance validity testing in the field of neuropsychology, both in terms of the science as well as the clinical application of this measurement technique. The second article of this series will review performance validity tests in terms of methods for development of these measures, and maximizing of diagnostic accuracy.

IPEN scientific and technical publications 1984-1986

International Nuclear Information System (INIS)

1988-01-01

The Instituto de Pesquisas Energeticas e Nucleares - IPEN (Energy Research Institute) from Sao Paulo, Brazil, was founded in 1956. Since its foundation, the main objectives of IPEN has been to undertake research and development into the peaceful uses of nuclear energy and to train scientific personnel to post-graduate level. The IPEN Scientific and Technical Publication - IPEN/STP, is a system developed at IPEN. Its purpose has been to generate a data base identifying the technical and scientific literature produced by IPEN staff members, published either in the Institute's series or in others brazilian and foreign publications. Documents cited in this 1984-1986 supplement include those in which IPEN staff members were authors or co-authors; document published by foreign research visitors while working at IPEN facilities; theses prepared by IPEN staff and reports in which IPEN is a corporate author. The IPEN technical publications reflect the main fields of research persuaded by the Institute, namely nuclear physics radiochemistry, chemical engineering, nuclear metallurgy and engineering and finally medical and industrial applications of radioisotopes. In this 1984-1986 supplement 458 document published by IPEN staff are cited, following the main subject heading of INIS Subject Categories. (author)

IPEN Scientific and technical publications 1982-1983

International Nuclear Information System (INIS)

1984-01-01

The Instituto de Pesquisas Energeticas e Nucleares - IPEN (Energy Research Institute) from Sao Paulo, Brazil, was founded in 1956. Since its foundation, the main objectives of IPEN has been to undertake research and development into the peaceful uses of nuclear energy and to train scientific personnel to post-graduate level. The IPEN Scientific and Technical Publication - IPEN/STP, is a system developed at IPEN. Its purpose has been to generate a data base identifying the technical and scientific literature produced by IPEN staff members, published either in the Institute's series or in others brazilian and foreign publications. Documents cited in this 1982-1983 supplement include those in which IPEN staff members were authors or co-authors; document published by foreign research visitors while working at IPEN facilities; theses prepared by IPEN staff and reports in which IPEN is a corporate author. The IPEN technical publications reflect the main fields of research persuaded by the Institute, namely nuclear physics radiochemistry, chemical engineering, nuclear metallurgy and engineering and finally medical and industrial applications of radioisotopes. In this 1982-1983 supplement 131 document published by IPEN staff are cited, following the main subject heading of INIS Subject Categories. (author)

SDMS: A scientific data management system

Science.gov (United States)

Massena, W. A.

1978-01-01

SDMS is a data base management system developed specifically to support scientific programming applications. It consists of a data definition program to define the forms of data bases, and FORTRAN-compatible subroutine calls to create and access data within them. Each SDMS data base contains one or more data sets. A data set has the form of a relation. Each column of a data set is defined to be either a key or data element. Key elements must be scalar. Data elements may also be vectors or matrices. The data elements in each row of the relation form an element set. SDMS permits direct storage and retrieval of an element set by specifying the corresponding key element values. To support the scientific environment, SDMS allows the dynamic creation of data bases via subroutine calls. It also allows intermediate or scratch data to be stored in temporary data bases which vanish at job end.

75 FR 8369 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-02-24

... for Scientific Review Special Emphasis Panel; RFA-RM-09-007: Pilot-Scale Libraries for High Throughput Screening. Date: March 15, 2010. Time: 8 a.m. to 7 p.m. Agenda: To review and evaluate grant applications...

76 FR 62082 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-10-06

... Committee: Center for Scientific Review Special Emphasis Panel, AREA applications in Child and Adult..., Comparative Medicine; 93.333, Clinical Research, 93.306, 93.333, 93.337, 93.393-93.396, 93.837-93.844, 93.846...

78 FR 50144 - Health Services Research and Development Service, Scientific Merit Review Board; Notice of Meeting

Science.gov (United States)

2013-08-16

... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service, Scientific Merit... management, and nursing research. Applications are reviewed for scientific and technical merit, mission... Advisory Committee Act, 5 U.S.C. App. 2, that the Health Services Research and Development Service (HSR&D...

Using Students' Design Tasks to Develop Scientific Abilities

Science.gov (United States)

Zou, Xueli

2007-11-01

To help students develop the scientific abilities desired in the 21st century workplace, four different types of student design tasks—observation, verification, application, and investigation experiments—have been developed and implemented in our calculus-based introductory courses. Students working in small groups are engaged in designing and conducting their own experiments to observe some physical phenomena, test a physical principle, build a real-life device, solve a complex problem, or conduct an open-inquiry investigation. A preliminary study has shown that, probed by a performance-based task, the identified scientific abilities are more explicitly demonstrated by design-lab students than non-design lab students. In this paper, detailed examples of the design tasks and assessment results will be reported.

Coupling Visualization and Data Analysis for Knowledge Discovery from Multi-dimensional Scientific Data

International Nuclear Information System (INIS)

Rubel, Oliver; Ahern, Sean; Bethel, E. Wes; Biggin, Mark D.; Childs, Hank; Cormier-Michel, Estelle; DePace, Angela; Eisen, Michael B.; Fowlkes, Charless C.; Geddes, Cameron G.R.; Hagen, Hans; Hamann, Bernd; Huang, Min-Yu; Keranen, Soile V.E.; Knowles, David W.; Hendriks, Chris L. Luengo; Malik, Jitendra; Meredith, Jeremy; Messmer, Peter; Prabhat; Ushizima, Daniela; Weber, Gunther H.; Wu, Kesheng

2010-01-01

Knowledge discovery from large and complex scientific data is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the growing number of data dimensions and data objects presents tremendous challenges for effective data analysis and data exploration methods and tools. The combination and close integration of methods from scientific visualization, information visualization, automated data analysis, and other enabling technologies 'such as efficient data management' supports knowledge discovery from multi-dimensional scientific data. This paper surveys two distinct applications in developmental biology and accelerator physics, illustrating the effectiveness of the described approach.

An integrated IaaS and PaaS architecture for scientific computing

OpenAIRE

Donvito, Giacinto; Blanquer, Ignacio

2015-01-01

Scientific applications often require multiple computing resources deployed on a coordinated way. The deployment of multiple resources require installing and configuring special software applications which should be updated when changes in the virtual infrastructure take place. When working on hybrid and federated cloud environments, restrictions on the hypervisor or cloud management platform must be minimised to facilitate geographic-wide brokering and cross-site deployments. Moreover, prese...

Presenting Fake Figures: A Tool to Teach Effective Scientific Figure Design

Directory of Open Access Journals (Sweden)

Veronica A. Segarra

2013-08-01

Full Text Available As trained scientists, we become adept not only at analyzing and understanding figures in the scientific literature, but also at designing figures to effectively represent our own data and findings. As educators, we strive to pass on these skills to our students, some of whom will ultimately become scientists themselves. Conveying the principles of effective figure design can be challenging, particularly when students have had little exposure to the process of reading scientific literature, much less writing a piece of scientific literature. Improvisational activities in the classroom reinforce teaching goals such as spontaneity, risk-taking, creativity, communication skills, team-building, and critical thinking (2. Indeed, improv training for scientists is becoming more common, helping scientists to communicate more spontaneously about their work and connect with their audience (1. In this article, we present an improvisational game that can aid in the teaching of effective scientific figure design. This “Present-a-Fake-Figure Exercise” is applicable to both the classroom and laboratory settings. In this learning activity, students improvise presenting fake scientific figures to an audience of their peers. These fake figures are prepared beforehand by the instructor and exemplify the do’s and don’ts of scientific figure design. Some of the learning outcomes of the activity include (1 identifying what makes a scientific figure cohesive, easy to analyze, and reader-friendly, and (2 identifying strategies that are useful in the design of a multi-panel figure to convey a scientific story.

General Critical Properties of the Dynamics of Scientific Discovery

Energy Technology Data Exchange (ETDEWEB)

Bettencourt, L. M. A. (LANL); Kaiser, D. I. (MIT)

2011-05-31

Scientific fields are difficult to define and compare, yet there is a general sense that they undergo similar stages of development. From this point of view it becomes important to determine if these superficial similarities can be translated into a general framework that would quantify the general advent and subsequent dynamics of scientific ideas. Such a framework would have important practical applications of allowing us to compare fields that superficially may appear different, in terms of their subject matter, research techniques, typical collaboration size, etc. Particularh' important in a field's history is the moment at which conceptual and technical unification allows widespread exchange of ideas and collaboration, at which point networks of collaboration show the analog of a percolation phenomenon, developing a giant connected component containing most authors. Here we investigate the generality of this topological transition in the collaboration structure of scientific fields as they grow and become denser. We develop a general theoretical framework in which each scientific field is an instantiation of the same large-scale topological critical phenomenon. We consider whether the evidence from a variety of specific fields is consistent with this picture, and estimate critical exponents associated with the transition. We then discuss the generality of the phenomenon and to what extent we may expect other scientific fields — including very large ones — to follow the same dynamics.

The Revista Scientific

Directory of Open Access Journals (Sweden)

Oscar Antonio Martínez Molina

2017-02-01

Full Text Available The Revista Scientific aims to publish quality papers that include the perspective of analysis in educational settings. Together with www.indtec.com.ve, this electronic publication aims to promote and disseminate, with seriousness and rigor, the academic production in this field. Editorial of the new stage Revista Scientific was created with the aim of constituting a reference space for scientific research in the field of research analysis that is carried out within the universities in Latin America, once the distribution list hosted on the INDTEC platform (http://www.indtec.com.ve is consolidated as a space for dissemination and development of new ideas and initiatives. The first presentation of INDTEC Magazine was held in August 2016 in Venezuela. Thanks to the support of the INDTEC platform, SCIENTIFIC Magazine has been able to develop from the cooperative work of the people who make up its Editorial Committee, Academic Committee and Scientific Committee in Electronic Edition, and of the referees of each one of the numbers. Part of the success is due to the motivation of its co-editors and excellent professionals from different parts of the world: Argentina, Belgium, Colombia, Cuba, Ecuador, Spain, Mexico, Venezuela, which form the various committees, with enthusiasm and joy participating in this project (whose organizational structure is presented in this edition and continues in increcendo. Also, the strategy adopted to edit a monographic number from the various events organized in the framework of the universities, has contributed to provide SCIENTIFIC with a point value speaker of intellectual progress in the field of education. SCIENTIFIC Magazine is currently indexed in ISI, International Scientific Indexing, Dubai - UAE; ROAD, the Directory of Open Access Scholarly Resources (ISSN International Center, France; REVENCYT-ULA, Venezuela; Google Scholar (Google Scholar, International Index; Published in Calaméo; ISSUU; Academia

Geo-scientific database for research and development purposes

International Nuclear Information System (INIS)

Tabani, P.; Mangeot, A.; Crabol, V.; Delage, P.; Dewonck, S.; Auriere, C.

2012-01-01

Document available in extended abstract form only. The Research and Development Division must manage, secure and reliable manner, a large number of data from scientific disciplines and diverse means of acquisition (observations, measurements, experiments, etc.). This management is particularly important for the Underground research Laboratory, the source of many recording continuous measurements. Thus, from its conception, Andra has implemented two management tools of scientific information, the 'Acquisition System and Data Management' [SAGD] and GEO database with its associated applications. Beyond its own needs, Andra wants to share its achievements with the scientific community, and it therefore provides the data stored in its databases or samples of rock or water when they are available. Acquisition and Data Management (SAGD) This system manages data from sensors installed at several sites. Some sites are on the surface (piezometric, atmospheric and environmental stations), the other are in the Underground Research Laboratory. This system also incorporates data from experiments in which Andra participates in Mont Terri Laboratory in Switzerland. S.A.G.D fulfils these objectives by: - Make available in real time on a single system, with scientists from Andra but also different partners or providers who need it, all experimental data from measurement points - Displaying the recorded data on temporal windows and specific time step, - Allowing remote control of the experimentations, - Ensuring the traceability of all recorded information, - Ensuring data storage in a data base. S.A.G.D has been deployed in the first experimental drift at -445 m in November 2004. It was subsequently extended to the underground Mont Terri laboratory in Switzerland in 2005, to the entire surface logging network of the Meuse / Haute-Marne Center in 2008 and to the environmental network in 2011. All information is acquired, stored and manage by a software called Geoscope. This software

75 FR 80830 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-12-23

... Committee: Endocrinology, Metabolism, Nutrition and Reproductive Sciences Integrated Review Group; Pregnancy... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda...

Scientific Programming Using Java: A Remote Sensing Example

Science.gov (United States)

Prados, Don; Mohamed, Mohamed A.; Johnson, Michael; Cao, Changyong; Gasser, Jerry

1999-01-01

This paper presents results of a project to port remote sensing code from the C programming language to Java. The advantages and disadvantages of using Java versus C as a scientific programming language in remote sensing applications are discussed. Remote sensing applications deal with voluminous data that require effective memory management, such as buffering operations, when processed. Some of these applications also implement complex computational algorithms, such as Fast Fourier Transformation analysis, that are very performance intensive. Factors considered include performance, precision, complexity, rapidity of development, ease of code reuse, ease of maintenance, memory management, and platform independence. Performance of radiometric calibration code written in Java for the graphical user interface and of using C for the domain model are also presented.

George Gamow: Scientific Amateur and Polymath

Science.gov (United States)

Harper, Eamon

George Gamow (1904-1968) was among the first of the many brilliant scientists who forsook Europe for the United States in the early 1930s. Although most were fleeing the fascist imperium of Hitler and Mussolini, Gamow was one of a few who managed to escape the burgeoning despotism of Stalin in the Soviet Union. His early application of quantum mechanics to the atomic nucleus and his subsequent insight into the role played by the physics of the atom and its nucleus in stars, galaxies, and the universe identifies him as a scientist of unusual genius. Gamow displayed a boisterous, infectious - almost Rutherfordian - interest in all aspects of pure science. His interests were broad and his industry prodigious. His scientific output covered areas as diverse as nuclear physics, astrophysics, cosmology, biological genetics, and the fascinating question of the relationship of the large-scale structure and development of the universe to the properties of elementary particles and fields. He also was an immensely imaginative and prolific author of popular expositions on scientific subjects. One who is as well-known for his authorship of the Mr. Tompkins series of science popularizations as for his contributions to the development of the physical consequences of the big-bang theory of the expanding universe and the prediction of the cosmic background radiation must be unique in the scientific pantheon.

Realism, instrumentalism, and scientific symbiosis: psychological theory as a search for truth and the discovery of solutions.

Science.gov (United States)

Cacioppo, John T; Semin, Gün R; Berntson, Gary G

2004-01-01

Scientific realism holds that scientific theories are approximations of universal truths about reality, whereas scientific instrumentalism posits that scientific theories are intellectual structures that provide adequate predictions of what is observed and useful frameworks for answering questions and solving problems in a given domain. These philosophical perspectives have different strengths and weaknesses and have been regarded as incommensurate: Scientific realism fosters theoretical rigor, verifiability, parsimony, and debate, whereas scientific instrumentalism fosters theoretical innovation, synthesis, generativeness, and scope. The authors review the evolution of scientific realism and instrumentalism in psychology and propose that the categorical distinction between the 2 is overstated as a prescription for scientific practice. The authors propose that the iterative deployment of these 2 perspectives, just as the iterative application of inductive and deductive reasoning in science, may promote more rigorous, integrative, cumulative, and useful scientific theories.

XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Year-end report FY17.

Energy Technology Data Exchange (ETDEWEB)

Moreland, Kenneth D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pugmire, David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rogers, David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Childs, Hank [Univ. of Oregon, Eugene, OR (United States); Ma, Kwan-Liu [Univ. of California, Davis, CA (United States); Geveci, Berk [Kitware, Inc., Clifton Park, NY (United States)

2017-10-01

The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressing four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.

The Scientific Competitiveness of Nations.

Science.gov (United States)

Cimini, Giulio; Gabrielli, Andrea; Sylos Labini, Francesco

2014-01-01

We use citation data of scientific articles produced by individual nations in different scientific domains to determine the structure and efficiency of national research systems. We characterize the scientific fitness of each nation-that is, the competitiveness of its research system-and the complexity of each scientific domain by means of a non-linear iterative algorithm able to assess quantitatively the advantage of scientific diversification. We find that technological leading nations, beyond having the largest production of scientific papers and the largest number of citations, do not specialize in a few scientific domains. Rather, they diversify as much as possible their research system. On the other side, less developed nations are competitive only in scientific domains where also many other nations are present. Diversification thus represents the key element that correlates with scientific and technological competitiveness. A remarkable implication of this structure of the scientific competition is that the scientific domains playing the role of "markers" of national scientific competitiveness are those not necessarily of high technological requirements, but rather addressing the most "sophisticated" needs of the society.

An evidence-based environmental perspective of manufactured silver nanoparticle in syntheses and applications: A systematic review and critical appraisal of peer-reviewed scientific papers

International Nuclear Information System (INIS)

Tolaymat, Thabet M.; El Badawy, Amro M.; Genaidy, Ash; Scheckel, Kirk G.; Luxton, Todd P.; Suidan, Makram

2010-01-01

Background: Most recently, renewed interest has arisen in manufactured silver nanomaterials because of their unusually enhanced physicochemical properties and biological activities compared to the bulk parent materials. A wide range of applications has emerged in consumer products ranging from disinfecting medical devices and home appliances to water treatment. Because the hypothesized mechanisms that govern the fate and transport of bulk materials may not directly apply to materials at the nanoscale, there are great concerns in the regulatory and research communities about potential environmental impacts associated with the use of silver nanoparticles. In particular, the unlimited combinations of properties emerging from the syntheses and applications of silver nanoparticles are presenting an urgent need to document the predominant salt precursors, reducing agents and stabilizing agents utilized in the synthesis processes of silver nanoparticles to guide the massive efforts required for environmental risk assessment and management. Objectives: The primary objective of this study is to present an evidence-based environmental perspective of silver nanoparticle properties in syntheses and applications. The following specific aims are designed to achieve the study objective: Aim 1 - to document the salt precursors and agents utilized in synthesizing silver nanoparticles; Aim 2 - to determine the characteristics of silver nanoparticles currently in use in the scientific literature when integrated in polymer matrices to form nanocomposites and combined with other metal nanoparticles to form bimetallic nanoparticles; Aim 3 - to provide a summary of the morphology of silver nanoparticles; and (4) Aim 4 - to provide an environmental perspective of the evidence presented in Aims 1 to 3. Methods: A comprehensive electronic search of scientific databases was conducted in support of the study objectives. Specific inclusion criteria were applied to gather the most pertinent

An evidence-based environmental perspective of manufactured silver nanoparticle in syntheses and applications: A systematic review and critical appraisal of peer-reviewed scientific papers

Energy Technology Data Exchange (ETDEWEB)

Tolaymat, Thabet M., E-mail: tolaymat.thabet@epa.gov [USEPA Office of Research and Development, National Risk Management Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45224 (United States); El Badawy, Amro M. [Dept. of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, OH (United States); Genaidy, Ash [WorldTek Inc, Cincinnati, OH (United States); Scheckel, Kirk G.; Luxton, Todd P. [USEPA Office of Research and Development, National Risk Management Laboratory, 26 West Martin Luther King Drive, Cincinnati, OH 45224 (United States); Suidan, Makram [Dept. of Civil and Environmental Engineering, University of Cincinnati, Cincinnati, OH (United States)

2010-02-01

Background: Most recently, renewed interest has arisen in manufactured silver nanomaterials because of their unusually enhanced physicochemical properties and biological activities compared to the bulk parent materials. A wide range of applications has emerged in consumer products ranging from disinfecting medical devices and home appliances to water treatment. Because the hypothesized mechanisms that govern the fate and transport of bulk materials may not directly apply to materials at the nanoscale, there are great concerns in the regulatory and research communities about potential environmental impacts associated with the use of silver nanoparticles. In particular, the unlimited combinations of properties emerging from the syntheses and applications of silver nanoparticles are presenting an urgent need to document the predominant salt precursors, reducing agents and stabilizing agents utilized in the synthesis processes of silver nanoparticles to guide the massive efforts required for environmental risk assessment and management. Objectives: The primary objective of this study is to present an evidence-based environmental perspective of silver nanoparticle properties in syntheses and applications. The following specific aims are designed to achieve the study objective: Aim 1 - to document the salt precursors and agents utilized in synthesizing silver nanoparticles; Aim 2 - to determine the characteristics of silver nanoparticles currently in use in the scientific literature when integrated in polymer matrices to form nanocomposites and combined with other metal nanoparticles to form bimetallic nanoparticles; Aim 3 - to provide a summary of the morphology of silver nanoparticles; and (4) Aim 4 - to provide an environmental perspective of the evidence presented in Aims 1 to 3. Methods: A comprehensive electronic search of scientific databases was conducted in support of the study objectives. Specific inclusion criteria were applied to gather the most pertinent

Improving imbalanced scientific text classification using sampling strategies and dictionaries

Directory of Open Access Journals (Sweden)

Borrajo L.

2011-12-01

Full Text Available Many real applications have the imbalanced class distribution problem, where one of the classes is represented by a very small number of cases compared to the other classes. One of the systems affected are those related to the recovery and classification of scientific documentation.

Beyond 100 Tesla: Scientific experiments using single-turn coils

Science.gov (United States)

Portugall, Oliver; Solane, Pierre Yves; Plochocka, Paulina; Maude, Duncan K.; Nicholas, Robin J.

2013-01-01

Current opportunities and recent examples for research in magnetic fields well above 100 T using single-turn coils are discussed. After a general introduction into basic principles and technical constraints associated with the generation of Megagauss fields we discuss data obtained at the LNCMI Toulouse, where such fields are routinely used for scientific applications.

Cloud computing for data-intensive applications

CERN Document Server

Li, Xiaolin

2014-01-01

This book presents a range of cloud computing platforms for data-intensive scientific applications. It covers systems that deliver infrastructure as a service, including: HPC as a service; virtual networks as a service; scalable and reliable storage; algorithms that manage vast cloud resources and applications runtime; and programming models that enable pragmatic programming and implementation toolkits for eScience applications. Many scientific applications in clouds are also introduced, such as bioinformatics, biology, weather forecasting and social networks. Most chapters include case studie

Scientific Utopia: An agenda for improving scientific communication (Invited)

Science.gov (United States)

Nosek, B.

2013-12-01

The scientist's primary incentive is publication. In the present culture, open practices do not increase chances of publication, and they often require additional work. Practicing the abstract scientific values of openness and reproducibility thus requires behaviors in addition to those relevant for the primary, concrete rewards. When in conflict, concrete rewards are likely to dominate over abstract ones. As a consequence, the reward structure for scientists does not encourage openness and reproducibility. This can be changed by nudging incentives to align scientific practices with scientific values. Science will benefit by creating and connecting technologies that nudge incentives while supporting and improving the scientific workflow. For example, it should be as easy to search the research literature for my topic as it is to search the Internet to find hilarious videos of cats falling off of furniture. I will introduce the Center for Open Science (http://centerforopenscience.org/) and efforts to improve openness and reproducibility such as http://openscienceframework.org/. There will be no cats.

Elastic Scheduling of Scientific Workflows under Deadline Constraints in Cloud Computing Environments

Directory of Open Access Journals (Sweden)

Nazia Anwar

2018-01-01

Full Text Available Scientific workflow applications are collections of several structured activities and fine-grained computational tasks. Scientific workflow scheduling in cloud computing is a challenging research topic due to its distinctive features. In cloud environments, it has become critical to perform efficient task scheduling resulting in reduced scheduling overhead, minimized cost and maximized resource utilization while still meeting the user-specified overall deadline. This paper proposes a strategy, Dynamic Scheduling of Bag of Tasks based workflows (DSB, for scheduling scientific workflows with the aim to minimize financial cost of leasing Virtual Machines (VMs under a user-defined deadline constraint. The proposed model groups the workflow into Bag of Tasks (BoTs based on data dependency and priority constraints and thereafter optimizes the allocation and scheduling of BoTs on elastic, heterogeneous and dynamically provisioned cloud resources called VMs in order to attain the proposed method’s objectives. The proposed approach considers pay-as-you-go Infrastructure as a Service (IaaS clouds having inherent features such as elasticity, abundance, heterogeneity and VM provisioning delays. A trace-based simulation using benchmark scientific workflows representing real world applications, demonstrates a significant reduction in workflow computation cost while the workflow deadline is met. The results validate that the proposed model produces better success rates to meet deadlines and cost efficiencies in comparison to adapted state-of-the-art algorithms for similar problems.

Performance evaluation of scientific programs on advanced architecture computers

International Nuclear Information System (INIS)

Walker, D.W.; Messina, P.; Baille, C.F.

1988-01-01

Recently a number of advanced architecture machines have become commercially available. These new machines promise better cost-performance then traditional computers, and some of them have the potential of competing with current supercomputers, such as the Cray X/MP, in terms of maximum performance. This paper describes an on-going project to evaluate a broad range of advanced architecture computers using a number of complete scientific application programs. The computers to be evaluated include distributed- memory machines such as the NCUBE, INTEL and Caltech/JPL hypercubes, and the MEIKO computing surface, shared-memory, bus architecture machines such as the Sequent Balance and the Alliant, very long instruction word machines such as the Multiflow Trace 7/200 computer, traditional supercomputers such as the Cray X.MP and Cray-2, and SIMD machines such as the Connection Machine. Currently 11 application codes from a number of scientific disciplines have been selected, although it is not intended to run all codes on all machines. Results are presented for two of the codes (QCD and missile tracking), and future work is proposed

Scientific Process Flowchart Assessment (SPFA): A Method for Evaluating Changes in Understanding and Visualization of the Scientific Process in a Multidisciplinary Student Population.

Science.gov (United States)

Wilson, Kristy J; Rigakos, Bessie

The scientific process is nonlinear, unpredictable, and ongoing. Assessing the nature of science is difficult with methods that rely on Likert-scale or multiple-choice questions. This study evaluated conceptions about the scientific process using student-created visual representations that we term "flowcharts." The methodology, Scientific Process Flowchart Assessment (SPFA), consisted of a prompt and rubric that was designed to assess students' understanding of the scientific process. Forty flowcharts representing a multidisciplinary group without intervention and 26 flowcharts representing pre- and postinstruction were evaluated over five dimensions: connections, experimental design, reasons for doing science, nature of science, and interconnectivity. Pre to post flowcharts showed a statistically significant improvement in the number of items and ratings for the dimensions. Comparison of the terms used and connections between terms on student flowcharts revealed an enhanced and more nuanced understanding of the scientific process, especially in the areas of application to society and communication within the scientific community. We propose that SPFA can be used in a variety of circumstances, including in the determination of what curricula or interventions would be useful in a course or program, in the assessment of curriculum, or in the evaluation of students performing research projects. © 2016 K. J. Wilson and B. Rigakos. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Balancing interests: limitations to the right to enjoy the benefits of scientific progress and its applications / Une balance des intérêts - Les restrictions au droit de bénéficier du progrès scientifique et de ses applications

NARCIS (Netherlands)

Donders, Y.

2015-01-01

The right to enjoy the benefits of scientific progress and its applications (REBSP) is still, despite increased attention from United Nations (UN) human rights bodies and academics, very much unknown. Several studies and reports have been elaborated on the normative content and State obligations of

Materials of 45. Scientific Assembly of Polish Chemical Society. Volumes 1-3

International Nuclear Information System (INIS)

2002-01-01

Scientific assemblies of Polish Chemical Society are the most important chemical meeting organised annually in Poland. Basic as well as application studies in all chemical branches have been extensively presented. The next subjects was proposed as scientific sessions and symposia topics: organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, technology and chemical engineering, polymer chemistry, solid state chemistry, catalysis, biological chemistry, chemistry and technology of coal, environmental protection, didactics of chemistry, history of chemistry, young scientist forum, flow analysis, and high-energy materials

Analyzing Data Citations to Assess the Scientific and Societal Value of Scientific Data

Science.gov (United States)

Chen, R. S.; Downs, R. R.

2012-12-01

Stakeholders in the creation, distribution, support, funding, and use of scientific data can benefit by understanding the value that the data have for society and science. For decades, the scientific community has been using citations of articles in the published scientific literature as one of the primary measures used for evaluating the performance of scientists, departments, institutions, and scientific disciplines. Similarly, citations in the published literature of scientific data may be useful for measuring and assessing the value of the scientific data and the performance of the individuals, projects, programs, and organizations that have contributed to the data and their use. The results of citation analysis and other assessments of the value of data also can contribute to planning for future data collection, development, distribution, and preservation efforts. The planned release of new data citation indexes and the more widespread adoption of unique data identifiers and automated attribution mechanisms have the potential to improve significantly the capabilities for analyzing citations of scientific data. In addition, rapid developments in the systems and capabilities for disseminating data, along with education and workforce development on the importance of data attribution and on techniques for data citation, can improve practices for citing scientific data. Such practices need to lead not only to better aggregate statistics about data citation, but also to improved characterization and understanding of the impact of data use in terms of the benefits for science and society. Analyses of citations in the scientific literature were conducted for data that were distributed by an interdisciplinary scientific data center during a five-year period (1997 - 2011), to identify the scientific fields represented by the journals and books in which the data were cited. Secondary citation analysis also was conducted for a sample of scientific publications that used

Reverberation index: a novel metric by which to quantify the impact of a scientific entity on a given field.

Science.gov (United States)

Kathleen Bandt, S; Dacey, Ralph G

2017-09-01

The authors propose a novel bibilometric index, the reverberation index (r-index), as a comparative assessment tool for use in determining differential reverberation between scientific fields for a given scientific entity. Conversely, this may allow comparison of 2 similar scientific entities within a single scientific field. This index is calculated using a relatively simple 3-step process. Briefly, Thompson Reuters' Web of Science is used to produce a citation report for a unique search parameter (this may be an author, journal article, or topical key word). From this citation report, a list of citing journals is retrieved from which a weighted ratio of citation patterns across journals can be calculated. This r-index is then used to compare the reverberation of the original search parameter across different fields of study or wherever a comparison is required. The advantage of this novel tool is its ability to transcend a specific component of the scientific process. This affords application to a diverse range of entities, including an author, a journal article, or a topical key word, for effective comparison of that entity's reverberation within a scientific arena. The authors introduce the context for and applications of the r-index, emphasizing neurosurgical topics and journals for illustration purposes. It should be kept in mind, however, that the r-index is readily applicable across all fields of study.

Application of satellite information for decision of scientific and applied tasks

Science.gov (United States)

Lyalko, Vadim

these are territories with high density of population and this is connected with unequal population and industry allocation on the territory of Ukraine. During 2009 it was conducted comparative data analysis about changes of greenhouse gases concen-tration over the territory of Ukraine from satellites ENVISAT (ESA, sensor SCIAMACHI) and Aqua (NASA, sensor AIRS). The analysis showed that data from different satellites complement one another and correspond to general tendencies which were fixed by ground methods. Those it was obtained the opportunity considerably increase the reliability of satellite assessments. UNO International Conference on Climate Changes which came to an end in December 2009 in Copenhagen confirmed the necessity to decrease greenhouse gases emissions for all coun-tries and continue to implement measures, according to requirements of Kyoto Protocol, for the society adaptation to climate changes. Thereby it's reasonable to carry out international researches within the framework of correspondent project, using obtained experience of our previous results in this sphere. The aim of these works is creation of the system of space audit monitoring of greenhouse gases balance for the reliable grounding and specification of their quotas for different countries and assessment of potential opportunities for quotas trading, in particular by Ukraine. To do this it's necessary to base the role of future Ukrainian satellites with correspondent sensors and systems of tested polygons. 2. Analysis of biophysical and spectral parameters changes for the geosystems with the aim of ecological forecasting. It was created the scientific base for risks forecasting of hydrologi-cal emergency situations (i.e. floods) and events induced by them (slides and submergences) during the further 30 years. The development is based on the application of energy-mass ex-change modeling in the geosystems and changes of climatic indications. Implementation of the developed approaches showed

INTEGRATION OF UKRAINIAN INDUSTRY SCIENTIFIC PERIODACLS INTO WORLD SCIENTIFIC INFORMATION SPACE: PROBLEMS AND SOLUTIONS

Directory of Open Access Journals (Sweden)

T. O. Kolesnykova

2013-11-01

Full Text Available Purpose. Problem of representation lack of scientists’ publications, including transport scientists, in the international scientometric databases is the urgent one for Ukrainian science. To solve the problem one should study the structure and quality of the information flow of scientific periodicals of railway universities in Ukraine and to determine the integration algorithm of scientific publications of Ukrainian scientists into the world scientific information space. Methodology. Applying the methods of scientific analysis, synthesis, analogy, comparison and prediction the author has investigated the problem of scientific knowledge distribution using formal communications. The readiness of Ukrainian railway periodicals to registration procedure in the international scientometric systems was analyzed. The level of representation of articles and authors of Ukrainian railway universities in scientometric database Scopus was studied. Findings. Monitoring of the portals of railway industry universities of Ukraine and the sites of their scientific periodicals and analysis of obtained data prove insufficient readiness of most scientific publications for submission to scientometric database. The ways providing sufficient "visibility" of industry periodicals of Ukrainian universities in the global scientific information space were proposed. Originality. The structure and quality of documentary flow of scientific periodicals in railway transport universities of Ukraine and its reflection in scientometric DB Scopus were first investigated. The basic directions of university activities to integrate the results of transport scientists research into the global scientific digital environment were outlined. It was determined the leading role of university libraries in the integration processes of scientific documentary resources of universities into the global scientific and information communicative space. Practical value. Implementation of the proposed

Methods to extract information on the atomic and molecular states from scientific abstracts

International Nuclear Information System (INIS)

Sasaki, Akira; Ueshima, Yutaka; Yamagiwa, Mitsuru; Murata, Masaki; Kanamaru, Toshiyuki; Shirado, Tamotsu; Isahara, Hitoshi

2005-01-01

We propose a new application of information technology to recognize and extract expressions of atomic and molecular states from electrical forms of scientific abstracts. Present results will help scientists to understand atomic states as well as the physics discussed in the articles. Combining with the internet search engines, it will make one possible to collect not only atomic and molecular data but broader scientific information over a wide range of research fields. (author)

Teaching Physics at Preschool Level for Mexican Students in Order to Achieve the National Scientific Standards

Science.gov (United States)

Ramírez Díaz, Mario H.; Nieto Betance, Gabriela; García Trujillo, Luís Antonio; Chávez-Campos, David A.

2015-01-01

In its program of studies for preschool level, the Secretary of Public Education of Mexico promoted development of four standards of science: Scientific knowledge, applications of scientific knowledge and technology, skills associated to science, and attitudes associated to science. However, to develop this skills and reach out the standards there…

A Complexity Approach to Evaluating National Scientific Systems through International Scientific Collaborations

Science.gov (United States)

Zelnio, Ryan J.

2013-01-01

This dissertation seeks to contribute to a fuller understanding of how international scientific collaboration has affected national scientific systems. It does this by developing three methodological approaches grounded in social complexity theory and applying them to the evaluation of national scientific systems. The first methodology identifies…

[Financing of the scientific publication and protection of the scientific knowledge].

Science.gov (United States)

Oliveira Filho, Renato Santos de; Hochman, Bernardo; Nahas, Fabio Xerfan; Ferreira, Lydia Masako

2005-01-01

The main purpose of a study is its publication on a scientific journal. Research financing agencies are important institutions so that studies can be developed and published. The most important research financing agencies that are discussed in this article are: "Coordenação de Aperfeiçoamento de Pessoal de Nível Superior" (CAPES), "Conselho Nacional de Desenvolvimento Científico e Tecnológico" (CNPq) and "Fundação de Amparo à Pesquisa do Estado de São Paulo" (FAPESP). CAPES' activities can be grouped in four different strategy lines: a) it evaluates the stricto sensu, at the post-graduation level; b) it provides access and development of scientific research; c) it provides investment on the development of high qualified human resources in Brazil and abroad, and d) it promotes international scientific cooperation. Although CAPES does not support directly scientific publications, almost all actions of this agency contribute to the development of scientific research and publication. CNPq has two main purposes: financing researches and development of human resources. It provides the researchers with financial aid to scientific publication. The grants for editing were specifically created for supporting the national scientific and technical publications edited by Brazilians institutions or societies. CNPq can also support Congresses, Symposiums and similar short-term courses. The Plataforma Lattes is also a branch of CNPq on which the Curriculum Lattes is available. This site has the curriculum vitae of the scientific community and is of great value for researchers. FAPESP also finances journal publications, articles and books that bring up original results of studies made by researchers from the state of São Paulo. It finances, partially, the travel expenses of innovative papers authors in meetings within the country or abroad. Brazilian authors are increasing the number of international publications. Universities, research institutes, financing agencies and

Scientific work environments in the next decade

Science.gov (United States)

Gomez, Julian E.

1989-01-01

The applications of contemporary computer graphics to scientific visualization is described, with emphasis on the nonintuitive problems. A radically different approach is proposed which centers on the idea of the scientist being in the simulation display space rather than observing it on a screen. Interaction is performed with nonstandard input devices to preserve the feeling of being immersed in the three-dimensional display space. Construction of such a system could begin now with currently available technology.

Four stages of a scientific discipline; four types of scientist.

Science.gov (United States)

Shneider, Alexander M

2009-05-01

In this article I propose the classification of the evolutionary stages that a scientific discipline evolves through and the type of scientists that are the most productive at each stage. I believe that each scientific discipline evolves sequentially through four stages. Scientists at stage one introduce new objects and phenomena as subject matter for a new scientific discipline. To do this they have to introduce a new language adequately describing the subject matter. At stage two, scientists develop a toolbox of methods and techniques for the new discipline. Owing to this advancement in methodology, the spectrum of objects and phenomena that fall into the realm of the new science are further understood at this stage. Most of the specific knowledge is generated at the third stage, at which the highest number of original research publications is generated. The majority of third-stage investigation is based on the initial application of new research methods to objects and/or phenomena. The purpose of the fourth stage is to maintain and pass on scientific knowledge generated during the first three stages. Groundbreaking new discoveries are not made at this stage. However, new ways to present scientific information are generated, and crucial revisions are often made of the role of the discipline within the constantly evolving scientific environment. The very nature of each stage determines the optimal psychological type and modus operandi of the scientist operating within it. Thus, it is not only the talent and devotion of scientists that determines whether they are capable of contributing substantially but, rather, whether they have the 'right type' of talent for the chosen scientific discipline at that time. Understanding the four different evolutionary stages of a scientific discipline might be instrumental for many scientists in optimizing their career path, in addition to being useful in assembling scientific teams, precluding conflicts and maximizing

On the Possibility of a Scientific Theory of Scientific Method.

Science.gov (United States)

Nola, Robert

1999-01-01

Discusses the philosophical strengths and weaknesses of Laudan's normative naturalism, which understands the principles of scientific method to be akin to scientific hypotheses, and therefore open to test like any principle of science. Contains 19 references. (Author/WRM)

77 FR 63845 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-10-17

... individuals associated with the grant applications, the disclosure of which would constitute a clearly...; Behavioral and Social Science Approaches to Preventing HIV/ AIDS Study Section. Date: November 8-9, 2012... Committee: Center for Scientific Review Special Emphasis Panel; Small Business: Cancer Diagnostics and...

76 FR 66075 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-10-25

...: Non-HIV Diagnostics, Food Safety, Sterilization/Disinfection and Bioremediation. Date: November 17-18... Hotel, 4300 Military Road, NW., Washington, DC 20015. Contact Person: Gagan Pandya, PhD, Scientific... applications. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD 20852. Contact Person...

77 FR 3478 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-24

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... evaluate grant applications. Place: Sheraton Delfina Santa Monica Hotel, 530 West Pico Boulevard, Santa... Review, National Institutes of Health, 6701 Rockledge Drive, Room 4132, MSC 7802, Bethesda, MD 20892...

Scientific visualization for enhanced interpretation and communication of geoscientific information

International Nuclear Information System (INIS)

Vorauer, A.; Cotesta, L.

2006-01-01

Ontario Power Generation's Deep Geologic Repository Technology Program has undertaken applied research into the application of scientific visualization technologies to: i) improve the interpretation and synthesis of complex geoscientific field data; ii) facilitate the development of defensible conceptual site descriptive models; and iii) enhance communication between multi-disciplinary site investigation teams and other stakeholders. Two scientific visualization projects are summarized that benefited from the use of the Gocad earth modelling software and were supported by an immersive virtual reality laboratory: i) the Moderately Fractured Rock experiment at the 125,000 m 3 block scale; and ii) the Sub-regional Flow System Modelling Project at the 100 km 2 scale. (author)

The 1 MV multi-element AMS system for biomedical applications at the Netherlands Organization for Applied Scientific Research (TNO)

Energy Technology Data Exchange (ETDEWEB)

Klein, Matthias, E-mail: mklein@highvolteng.com [High Voltage Engineering Europa B.V., P.O. Box 99, 3800 AB Amersfoort (Netherlands); Vaes, W.H.J.; Fabriek, B.; Sandman, H. [TNO, P.O. Box 360, 3700 AJ Zeist (Netherlands); Mous, D.J.W.; Gottdang, A. [High Voltage Engineering Europa B.V., P.O. Box 99, 3800 AB Amersfoort (Netherlands)

2013-01-15

The Netherlands Organization for Applied Scientific Research (TNO) has installed a compact 1 MV multi-element AMS system manufactured by High Voltage Engineering Europa B.V., The Netherlands. TNO performs clinical research programs for pharmaceutical and innovative foods industry to obtain early pharmacokinetic data and to provide anti-osteoporotic efficacy data of new treatments. The AMS system will analyze carbon, iodine and calcium samples for this purpose. The first measurements on blank samples indicate background levels in the low 10{sup -12} for calcium and iodine, making the system well suited for these biomedical applications. Carbon blanks have been measured at low 10{sup -16}. For unattended, around-the-clock analysis, the system features the 200 sample version of the SO110 hybrid ion source and user friendly control software.

VisTrails is an open-source scientific workflow and provenance management system

CSIR Research Space (South Africa)

Mthombeni, Thabo DM

2011-12-01

Full Text Available VisTrails is an open-source scientific workflow and provenance management system that provides support for simulations, data exploration and visualization. Whereas workflows have been traditionally used to automate repetitive tasks, for applications...

Simplifying the parallelization of scientific codes by a function-centric approach in Python

International Nuclear Information System (INIS)

Nilsen, Jon K; Cai Xing; Langtangen, Hans Petter; Hoeyland, Bjoern

2010-01-01

The purpose of this paper is to show how existing scientific software can be parallelized using a separate thin layer of Python code where all parallelization-specific tasks are implemented. We provide specific examples of such a Python code layer, which can act as templates for parallelizing a wide set of serial scientific codes. The use of Python for parallelization is motivated by the fact that the language is well suited for reusing existing serial codes programmed in other languages. The extreme flexibility of Python with regard to handling functions makes it very easy to wrap up decomposed computational tasks of a serial scientific application as Python functions. Many parallelization-specific components can be implemented as generic Python functions, which may take as input those wrapped functions that perform concrete computational tasks. The overall programming effort needed by this parallelization approach is limited, and the resulting parallel Python scripts have a compact and clean structure. The usefulness of the parallelization approach is exemplified by three different classes of application in natural and social sciences.

Expectations for a scientific collaboratory

DEFF Research Database (Denmark)

Sonnenwald, Diane H.

2003-01-01

In the past decade, a number of scientific collaboratories have emerged, yet adoption of scientific collaboratories remains limited. Meeting expectations is one factor that influences adoption of innovations, including scientific collaboratories. This paper investigates expectations scientists have...... with respect to scientific collaboratories. Interviews were conducted with 17 scientists who work in a variety of settings and have a range of experience conducting and managing scientific research. Results indicate that scientists expect a collaboratory to: support their strategic plans; facilitate management...... of the scientific process; have a positive or neutral impact on scientific outcomes; provide advantages and disadvantages for scientific task execution; and provide personal conveniences when collaborating across distances. These results both confirm existing knowledge and raise new issues for the design...

Impact of scientific and technological advances.

Science.gov (United States)

Dragan, I F; Dalessandri, D; Johnson, L A; Tucker, A; Walmsley, A D

2018-03-01

Advancements in research and technology are transforming our world. The dental profession is changing too, in the light of scientific discoveries that are advancing biological technology-from new biomaterials to unravelling the genetic make-up of the human being. As health professionals, we embrace a model of continuous quality improvement and lifelong learning. Our pedagogical approach to incorporating the plethora of scientific-technological advancements calls for us to shift our paradigm from emphasis on skill acquisition to knowledge application. The 2017 ADEE/ADEA workshop provided a forum to explore and discuss strategies to ensure faculty, students and, ultimately, patients are best positioned to exploit the opportunities that arise from integrating new technological advances and research outcomes. Participants discussed methods of incorporating the impact of new technologies and research findings into the education of our dental students. This report serves as a signpost of the way forward and how to promote incorporation of research and technology advances and lifelong learning into the dental education curriculum. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Enabling scientific workflows in virtual reality

Science.gov (United States)

Kreylos, O.; Bawden, G.; Bernardin, T.; Billen, M.I.; Cowgill, E.S.; Gold, R.D.; Hamann, B.; Jadamec, M.; Kellogg, L.H.; Staadt, O.G.; Sumner, D.Y.

2006-01-01

To advance research and improve the scientific return on data collection and interpretation efforts in the geosciences, we have developed methods of interactive visualization, with a special focus on immersive virtual reality (VR) environments. Earth sciences employ a strongly visual approach to the measurement and analysis of geologic data due to the spatial and temporal scales over which such data ranges, As observations and simulations increase in size and complexity, the Earth sciences are challenged to manage and interpret increasing amounts of data. Reaping the full intellectual benefits of immersive VR requires us to tailor exploratory approaches to scientific problems. These applications build on the visualization method's strengths, using both 3D perception and interaction with data and models, to take advantage of the skills and training of the geological scientists exploring their data in the VR environment. This interactive approach has enabled us to develop a suite of tools that are adaptable to a range of problems in the geosciences and beyond. Copyright ?? 2008 by the Association for Computing Machinery, Inc.

Representing Scientific Communities by Data Visualization (2/2)

CERN Multimedia

CERN. Geneva

2016-01-01

This work considers two types of communities as example: a scientific organization and an arising domain: the EPFL institutional community composed of faculty members and researchers and, at a world wide level, the emerging community of Digital Humanities researchers. For both cases, the research is organised as a process going from graphical research to actual materialization as physical artefacts (posters, maps, etc.), possibly extended using digital devices (augmented reality applications). T...

75 FR 51239 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2010-08-19

... operation, i.e., scanning tunneling microscopy and atomic force microscopy. Justification for Duty-Free... Microscope System for Application in High Magnetic Fields. Manufacturer: Omicron Nanotechnology, Germany...

75 FR 34096 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2010-06-16

... University Department of Chemistry, 3501 Laclede Ave., St. Louis, MO 63103. Instrument: Electron Microscope..., enhanced thermal conductivity (lubricants), thermally stable, light-weight materials for space applications...

Bibliometric analysis of scientific production about Linked Data

Directory of Open Access Journals (Sweden)

Leandro Dal Pizzol

2015-09-01

Full Text Available Introduction: Since Tim Berners-Lee coined the term Linked Data in 2006, many studies have emerged based on this initiative. Whether in the form of information access initiatives, whether in applications based on this data type, the interest in this new way to publish and consume information on the Web is increasingly in focus. Objective: In this paper, we present a bibliometric review with the aim of contributing to a better understanding and clarification of concepts and terms associated with the area of Linked Data. Methodology: We have used the Web of Science (WoS, Scopus, EBSCO and IEEE scientific databases, in order to find the existing studies about Linked Data until October 2012. Results: We have mapped 148 scientific papers that address the above issue, written by 409 authors from 160 institutions from 30 different countries. Through the analysis of the articles, it was found that researches about Linked Data are concentrated in a small authors group, suggesting future research opportunities. Conclusions: Synthesizing the information related to the scientific publications in a given area allows building a theoretical background that supports the development of future researches.

The paradox of scientific expertise

DEFF Research Database (Denmark)

Alrøe, Hugo Fjelsted; Noe, Egon

2011-01-01

Modern societies depend on a growing production of scientific knowledge, which is based on the functional differentiation of science into still more specialised scientific disciplines and subdisciplines. This is the basis for the paradox of scientific expertise: The growth of science leads to a f...... cross-disciplinary research and in the collective use of different kinds of scientific expertise, and thereby make society better able to solve complex, real-world problems.......Modern societies depend on a growing production of scientific knowledge, which is based on the functional differentiation of science into still more specialised scientific disciplines and subdisciplines. This is the basis for the paradox of scientific expertise: The growth of science leads...... to a fragmentation of scientific expertise. To resolve this paradox, the present paper investigates three hypotheses: 1) All scientific knowledge is perspectival. 2) The perspectival structure of science leads to specific forms of knowledge asymmetries. 3) Such perspectival knowledge asymmetries must be handled...

On the Performance of the Python Programming Language for Serial and Parallel Scientific Computations

Directory of Open Access Journals (Sweden)

Xing Cai

2005-01-01

Full Text Available This article addresses the performance of scientific applications that use the Python programming language. First, we investigate several techniques for improving the computational efficiency of serial Python codes. Then, we discuss the basic programming techniques in Python for parallelizing serial scientific applications. It is shown that an efficient implementation of the array-related operations is essential for achieving good parallel performance, as for the serial case. Once the array-related operations are efficiently implemented, probably using a mixed-language implementation, good serial and parallel performance become achievable. This is confirmed by a set of numerical experiments. Python is also shown to be well suited for writing high-level parallel programs.

FPS scientific and supercomputers computers in chemistry

International Nuclear Information System (INIS)

Curington, I.J.

1987-01-01

FPS Array Processors, scientific computers, and highly parallel supercomputers are used in nearly all aspects of compute-intensive computational chemistry. A survey is made of work utilizing this equipment, both published and current research. The relationship of the computer architecture to computational chemistry is discussed, with specific reference to Molecular Dynamics, Quantum Monte Carlo simulations, and Molecular Graphics applications. Recent installations of the FPS T-Series are highlighted, and examples of Molecular Graphics programs running on the FPS-5000 are shown

Balance in scientific impact assessment: the EGU Awards Committe experience

Science.gov (United States)

Montanari, Alberto

2016-04-01

Evaluation of scientific impact is becoming an essential step all over the world for assigning academic positions, funding and recognition. Impact is generally assessed by means of objective bibliometric indicators which are frequently integrated with a subjective evaluation by one or more individuals. An essential requirement of impact assessment is to ensure balance across several potential discriminating factors, including gender, ethnics, culture, scientific field and many others. Scientific associations need to ensure balance in any step of their activity and in particular when electing their representatives, evaluating scientific contributions, reviewing papers and assigning awards. While ensuring balance is a strict necessity, how to get to target is still a matter of vivid debates. In fact, the context of science is very different with respect to the general context of society and the need for scientific associations to maintain confidentiality in their evaluation procedures makes the application of transparent procedures more complicated. This talk aims to present the experience and the efforts of the European Geosciences Union to ensure balance, with a particular focus on gender balance. Data and statistics will be presented in the attempt to provide constructive indications to get to the target of giving equal opportunities to researchers across gender, continents and ethnic groups. Science is a unifying discipline and balance will be vital to ensure that humans and our planet co-evolve sustainably.

List of scientific publications of the Kernforschungszentrum Karlsruhe of the year 1982

International Nuclear Information System (INIS)

1983-04-01

The scientific and technical-scientific publications of the Kernforschungszentrum Karlsruhe are published as books, as original contributions in scientific or technical journals, as habilitation theses, doctoral theses, diploma theses, as patens, as KfK reports (KfK=Kernforschungszentrum Karlsruhe), and are held as lectures at scientific meetings. This report KfK 3425 contains the titles of the documents which are published in 1982. Lectures which have not been printed yet are listed separately from the literature. All patent rights issued or published in the yeaer 1982 are cited: patents,(Offenlegungsschriften) published patent applications examined only as to abvious defects but not as to patentability (DE-OS), (Auslegeschriften) printed specifications of patent applications after examination (DE-AS). The list of publications is arranged by institutes. Unter ''projects'' only the published project reports as well as publications of the members of the respective project staff are listed. The publications printed at the Kernforschungszentrum from the r and d project ''production engineering (PFT)'' performed by the Kernforschungszentrum as the responsible body in cooperation with firms and institutes, as well as the projects ''process control with data processing devices (PDV)'' and ''computer-aided development, construction and fabrication (CAD)'' have also been included in the list. Moreover, the list contains the publications of the Kernforschungszentrum branch of the Bundesforschungsanstalt fuer Ernaehrung. In the last chapter-publications on guest experiments at the Kernforschungszentrum have been compiled. (orig./GG) [de

Scientific data analysis on data-parallel platforms.

Energy Technology Data Exchange (ETDEWEB)

Ulmer, Craig D.; Bayer, Gregory W.; Choe, Yung Ryn; Roe, Diana C.

2010-09-01

As scientific computing users migrate to petaflop platforms that promise to generate multi-terabyte datasets, there is a growing need in the community to be able to embed sophisticated analysis algorithms in the computing platforms' storage systems. Data Warehouse Appliances (DWAs) are attractive for this work, due to their ability to store and process massive datasets efficiently. While DWAs have been utilized effectively in data-mining and informatics applications, they remain largely unproven in scientific workloads. In this paper we present our experiences in adapting two mesh analysis algorithms to function on five different DWA architectures: two Netezza database appliances, an XtremeData dbX database, a LexisNexis DAS, and multiple Hadoop MapReduce clusters. The main contribution of this work is insight into the differences between these DWAs from a user's perspective. In addition, we present performance measurements for ten DWA systems to help understand the impact of different architectural trade-offs in these systems.

Strengthening the scientific basis of radiological protection

International Nuclear Information System (INIS)

Lazo, Edward

2016-01-01

, 1998 and 2007). With these analyses, the CRPPH has assessed the possible implications that emerging scientific results (e.g. recent findings on radiation effects on the lens of the eye), or that possible results (e.g. ongoing epidemiological studies that could show statistically significant cancer risks, or that could show no cancer risks at doses below 50 mSv) could have for the way that radiological protection is regulated and applied. The latest report in this series, Radiological Protection Science and Application (NEA, 2016), performs such an assessment for today's level of scientific understanding. (author)

Financial interest and its disclosure in scientific publications.

Science.gov (United States)

Krimsky, S; Rothenberg, L S

1998-07-15

Journal policies and requirements of funding agencies on financial disclosure of authors and grant applicants have divided editors and scientists who disagree on whether such policies can improve the integrity of science or manage conflicts of interest. Those opposed to such disclosure policies argue that financial interest is one of many interests held by scientists, is the least scientifically dangerous, and should not be singled out. Those who favor open reporting of financial interests argue that full disclosure removes the suspicion that something of relevance to objectivity is being hidden and allows readers to form their own opinions on whether a conflict of interest exists and what relevance that has to the study. The authors believe that the scientific community and the public will be best served by open publication of financial disclosures for readers and reviewers to evaluate.

77 FR 32942 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2012-06-04

... Statutory Import Programs Staff, Room 3720, U.S. Department of Commerce, Washington, DC 20230. Applications..., College Station, TX 77843-3123. Instrument: Arc melting system. Manufacturer: Edmund Beuhler GmbH, Germany...

Open scientific communication urged

Science.gov (United States)

Richman, Barbara T.

In a report released last week the National Academy of Sciences' Panel on Scientific Communication and National Security concluded that the ‘limited and uncertain benefits’ of controls on the dissemination of scientific and technological research are ‘outweighed by the importance of scientific progress, which open communication accelerates, to the overall welfare of the nation.’ The 18-member panel, chaired by Dale R. Corson, president emeritus of Cornell University, was created last spring (Eos, April 20, 1982, p. 241) to examine the delicate balance between open dissemination of scientific and technical information and the U.S. government's desire to protect scientific and technological achievements from being translated into military advantages for our political adversaries.The panel dealt almost exclusively with the relationship between the United States and the Soviet Union but noted that there are ‘clear problems in scientific communication and national security involving Third World countries.’ Further study of this matter is necessary.

Opal web services for biomedical applications.

Science.gov (United States)

Ren, Jingyuan; Williams, Nadya; Clementi, Luca; Krishnan, Sriram; Li, Wilfred W

2010-07-01

Biomedical applications have become increasingly complex, and they often require large-scale high-performance computing resources with a large number of processors and memory. The complexity of application deployment and the advances in cluster, grid and cloud computing require new modes of support for biomedical research. Scientific Software as a Service (sSaaS) enables scalable and transparent access to biomedical applications through simple standards-based Web interfaces. Towards this end, we built a production web server (http://ws.nbcr.net) in August 2007 to support the bioinformatics application called MEME. The server has grown since to include docking analysis with AutoDock and AutoDock Vina, electrostatic calculations using PDB2PQR and APBS, and off-target analysis using SMAP. All the applications on the servers are powered by Opal, a toolkit that allows users to wrap scientific applications easily as web services without any modification to the scientific codes, by writing simple XML configuration files. Opal allows both web forms-based access and programmatic access of all our applications. The Opal toolkit currently supports SOAP-based Web service access to a number of popular applications from the National Biomedical Computation Resource (NBCR) and affiliated collaborative and service projects. In addition, Opal's programmatic access capability allows our applications to be accessed through many workflow tools, including Vision, Kepler, Nimrod/K and VisTrails. From mid-August 2007 to the end of 2009, we have successfully executed 239,814 jobs. The number of successfully executed jobs more than doubled from 205 to 411 per day between 2008 and 2009. The Opal-enabled service model is useful for a wide range of applications. It provides for interoperation with other applications with Web Service interfaces, and allows application developers to focus on the scientific tool and workflow development. Web server availability: http://ws.nbcr.net.

Undergraduate honors students' images of science: Nature of scientific work and scientific knowledge

Science.gov (United States)

Wallace, Michael L.

This exploratory study assessed the influence of an implicit, inquiry-oriented nature of science (NOS) instructional approach undertaken in an interdisciplinary college science course on undergraduate honor students' (UHS) understanding of the aspects of NOS for scientific work and scientific knowledge. In this study, the nature of scientific work concentrated upon the delineation of science from pseudoscience and the value scientists place on reproducibility. The nature of scientific knowledge concentrated upon how UHS view scientific theories and how they believe scientists utilize scientific theories in their research. The 39 UHS who participated in the study were non-science majors enrolled in a Honors College sponsored interdisciplinary science course where the instructors took an implicit NOS instructional approach. An open-ended assessment instrument, the UFO Scenario, was designed for the course and used to assess UHS' images of science at the beginning and end of the semester. The mixed-design study employed both qualitative and quantitative techniques to analyze the open-ended responses. The qualitative techniques of open and axial coding were utilized to find recurring themes within UHS' responses. McNemar's chi-square test for two dependent samples was used to identify whether any statistically significant changes occurred within responses from the beginning to the end of the semester. At the start of the study, the majority of UHS held mixed NOS views, but were able to accurately define what a scientific theory is and explicate how scientists utilize theories within scientific research. Postinstruction assessment indicated that UHS did not make significant gains in their understanding of the nature of scientific work or scientific knowledge and their overall images of science remained static. The results of the present study found implicit NOS instruction even with an extensive inquiry-oriented component was an ineffective approach for modifying UHS

75 FR 51081 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2010-08-18

...: Pregnancy, Neonatology, and Nutrition. Date: September 7-8, 2010. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge Drive, Bethesda... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review...

78 FR 59040 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-09-25

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC..., National Institutes of Health, 6701 Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775...

Science Camps for Introducing Nature of Scientific Inquiry Through Student Inquiries in Nature: Two Applications with Retention Study

Science.gov (United States)

Leblebicioglu, G.; Abik, N. M.; Capkinoglu, E.; Metin, D.; Dogan, E. Eroglu; Cetin, P. S.; Schwartz, R.

2017-08-01

Scientific inquiry is widely accepted as a method of science teaching. Understanding its characteristics, called Nature of Scientific Inquiry (NOSI), is also necessary for a whole conception of scientific inquiry. In this study NOSI aspects were taught explicitly through student inquiries in nature in two summer science camps. Students conducted four inquiries through their questions about surrounding soil, water, plants, and animals under the guidance of university science educators. At the end of each investigation, students presented their inquiry. NOSI aspects were made explicit by one of the science educators in the context of the investigations. Effectiveness of the science camp program and its retention were determined by applying Views of Scientific Inquiry (VOSI-S) (Schwartz et al. 2008) questionnaire as pre-, post-, and retention test after two months. The patterns in the data were similar. The science camp program was effective in developing three of six NOSI aspects which were questions guide scientific research, multiple methods of research, and difference between data and evidence. Students' learning of these aspects was retained. Discussion about these and the other three aspects is included in the paper. Implications of differences between school and out-of-school science experiences are also discussed.

WWW: The Scientific Method

Science.gov (United States)

Blystone, Robert V.; Blodgett, Kevin

2006-01-01

The scientific method is the principal methodology by which biological knowledge is gained and disseminated. As fundamental as the scientific method may be, its historical development is poorly understood, its definition is variable, and its deployment is uneven. Scientific progress may occur without the strictures imposed by the formal…

77 FR 20360 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2012-04-04

... malfunctioning in diseases such as diabetes, cancer and heath disease, and understanding how the proteins are.... Docket Number: 12-012. Applicant: Alliance for Sustainable Energy, 1617 Cole Blvd. Golden, CO 80401-3305...

76 FR 20953 - Application(s) for Duty-Free Entry of Scientific Instruments

Science.gov (United States)

2011-04-14

... the U.S. Department of Commerce in Room 3720. Docket Number: 11-023. Applicant: UChicago Argonne, LLC... Ltd., Switzerland. Intended Use: The instrument will be used for resonant inelastic x-ray scattering...

eSciMart: Web Platform for Scientific Software Marketplace

Science.gov (United States)

Kryukov, A. P.; Demichev, A. P.

2016-10-01

In this paper we suggest a design of a web marketplace where users of scientific application software and databases, presented in the form of web services, as well as their providers will have presence simultaneously. The model, which will be the basis for the web marketplace is close to the customer-to-customer (C2C) model, which has been successfully used, for example, on the auction sites such as eBay (ebay.com). Unlike the classical model of C2C the suggested marketplace focuses on application software in the form of web services, and standardization of API through which application software will be integrated into the web marketplace. A prototype of such a platform, entitled eSciMart, is currently being developed at SINP MSU.

The Scientific Enterprise

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 13; Issue 9. The Scientific Enterprise - Assumptions, Problems, and Goals in the Modern Scientific Framework. V V Raman. Reflections Volume 13 Issue 9 September 2008 pp 885-894 ...

Concept Formation in Scientific Knowledge Discovery from a Constructivist View

Science.gov (United States)

Peng, Wei; Gero, John S.

The central goal of scientific knowledge discovery is to learn cause-effect relationships among natural phenomena presented as variables and the consequences their interactions. Scientific knowledge is normally expressed as scientific taxonomies and qualitative and quantitative laws [1]. This type of knowledge represents intrinsic regularities of the observed phenomena that can be used to explain and predict behaviors of the phenomena. It is a generalization that is abstracted and externalized from a set of contexts and applicable to a broader scope. Scientific knowledge is a type of third-person knowledge, i.e., knowledge that independent of a specific enquirer. Artificial intelligence approaches, particularly data mining algorithms that are used to identify meaningful patterns from large data sets, are approaches that aim to facilitate the knowledge discovery process [2]. A broad spectrum of algorithms has been developed in addressing classification, associative learning, and clustering problems. However, their linkages to people who use them have not been adequately explored. Issues in relation to supporting the interpretation of the patterns, the application of prior knowledge to the data mining process and addressing user interactions remain challenges for building knowledge discovery tools [3]. As a consequence, scientists rely on their experience to formulate problems, evaluate hypotheses, reason about untraceable factors and derive new problems. This type of knowledge which they have developed during their career is called "first-person" knowledge. The formation of scientific knowledge (third-person knowledge) is highly influenced by the enquirer's first-person knowledge construct, which is a result of his or her interactions with the environment. There have been attempts to craft automatic knowledge discovery tools but these systems are limited in their capabilities to handle the dynamics of personal experience. There are now trends in developing

Technical applications of aerogels

International Nuclear Information System (INIS)

Hrubesh, L.W.

1997-01-01

Aerogel materials posses such a wide variety of exceptional properties that a striking number of applications have developed for them. Many of the commercial applications of aerogels such as catalysts, thermal insulation, windows, and particle detectors are still under development and new application as have been publicized since the ISA4 Conference in 1994: e.g.; supercapacitors, insulation for heat storage in automobiles, electrodes for capacitive deionization, etc. More applications are evolving as the scientific and engineering community becomes familiar with the unusual and exceptional physical properties of aerogels, there are also scientific and technical application, as well. This paper discusses a variety of applications under development at Lawrence Livermore National Laboratory for which several types of aerogels are formed in custom sizes and shapes. Particular discussions will focus on the uses of aerogels for physics experiments which rely on the exceptional, sometimes unique, properties of aerogels

Strategies towards Evaluation beyond Scientific Impact. Pathways not only for Agricultural Research

Directory of Open Access Journals (Sweden)

Birge M. Wolf

2013-12-01

Full Text Available Various research fields, like organic agricultural research, are dedicated to solving real-world problems and contributing to sustainable development. Therefore, systems research and the application of interdisciplinary and transdisciplinary approaches are increasingly endorsed. However, research performance depends not only on self-conception, but also on framework conditions of the scientific system, which are not always of benefit to such research fields. Recently, science and its framework conditions have been under increasing scrutiny as regards their ability to serve societal benefit. This provides opportunities for (organic agricultural research to engage in the development of a research system that will serve its needs. This article focuses on possible strategies for facilitating a balanced research evaluation that recognises scientific quality as well as societal relevance and applicability. These strategies are (a to strengthen the general support for evaluation beyond scientific impact, and (b to provide accessible data for such evaluations. Synergies of interest are found between open access movements and research communities focusing on global challenges and sustainability. As both are committed to increasing the societal benefit of science, they may support evaluation criteria such as knowledge production and dissemination tailored to societal needs, and the use of open access. Additional synergies exist between all those who scrutinise current research evaluation systems for their ability to serve scientific quality, which is also a precondition for societal benefit. Here, digital communication technologies provide opportunities to increase effectiveness, transparency, fairness and plurality in the dissemination of scientific results, quality assurance and reputation. Furthermore, funders may support transdisciplinary approaches and open access and improve data availability for evaluation beyond scientific impact. If they begin to

1998-2001 Scientific Technological Report; Informe Cientifico Tecnologico 1998-2001

Energy Technology Data Exchange (ETDEWEB)

Gayoso C, C; Ezpinoza Z, M; Prado C, A; Robles N, A [eds.

2002-07-01

IPEN has elaborated the 1998-2001 Scientific-Technological Report as a result of several research and development works within the fields of production and services, and related with mining, archaeology, agriculture, biology, industry and medicine as well with tracer techniques in industry, welding quality control, speed and underground waters flows, direction, water treatment, environmental pollution, geothermy, production and calibration of radioactive sources, X-rays equipment quality control, neutron physics, neutron radiography, neutron activation analysis, water traces analysis, crystal growth and building of nuclear equipment. The 1998-2001 Scientific-Technological Report includes 148 papers divided in 8 subject matters: Nuclear and Reactor Physics, Nuclear Chemistry, Nuclear Engineering, Materials, Nuclear Safety, Protection and Radiological Safety, Nuclear Applications, and Rules and Regulation.

The emergence of translational epidemiology: from scientific discovery to population health impact.

Science.gov (United States)

Khoury, Muin J; Gwinn, Marta; Ioannidis, John P A

2010-09-01

Recent emphasis on translational research (TR) is highlighting the role of epidemiology in translating scientific discoveries into population health impact. The authors present applications of epidemiology in TR through 4 phases designated T1-T4, illustrated by examples from human genomics. In T1, epidemiology explores the role of a basic scientific discovery (e.g., a disease risk factor or biomarker) in developing a "candidate application" for use in practice (e.g., a test used to guide interventions). In T2, epidemiology can help to evaluate the efficacy of a candidate application by using observational studies and randomized controlled trials. In T3, epidemiology can help to assess facilitators and barriers for uptake and implementation of candidate applications in practice. In T4, epidemiology can help to assess the impact of using candidate applications on population health outcomes. Epidemiology also has a leading role in knowledge synthesis, especially using quantitative methods (e.g., meta-analysis). To explore the emergence of TR in epidemiology, the authors compared articles published in selected issues of the Journal in 1999 and 2009. The proportion of articles identified as translational doubled from 16% (11/69) in 1999 to 33% (22/66) in 2009 (P = 0.02). Epidemiology is increasingly recognized as an important component of TR. By quantifying and integrating knowledge across disciplines, epidemiology provides crucial methods and tools for TR.

Scientific developments ISFD3

Science.gov (United States)

Schropp, M.H.I.; Soong, T.W.

2006-01-01

Highlights, trends, and consensus from the 63 papers submitted to the Scientific Developments theme of the Third International Symposium on Flood Defence (ISFD) are presented. Realizing that absolute protection against flooding can never be guaranteed, trends in flood management have shifted: (1) from flood protection to flood-risk management, (2) from reinforcing structural protection to lowering flood levels, and (3) to sustainable management through integrated problem solving. Improved understanding of watershed responses, climate changes, applications of GIS and remote-sensing technologies, and advanced analytical tools appeared to be the driving forces for renewing flood-risk management strategies. Technical competence in integrating analytical tools to form the basin wide management systems are demonstrated by several large, transnation models. However, analyses from social-economic-environmental points of view are found lag in general. ?? 2006 Taylor & Francis Group.

Scientific foundation of regulating ionizing radiation: application of metrics for evaluation of regulatory science information.

Science.gov (United States)

Moghissi, A Alan; Gerraa, Vikrham Kumar; McBride, Dennis K; Swetnam, Michael

2014-11-01

This paper starts by describing the historical evolution of assessment of biologic effects of ionizing radiation leading to the linear non-threshold (LNT) system currently used to regulate exposure to ionizing radiation. The paper describes briefly the concept of Best Available Science (BAS) and Metrics for Evaluation of Scientific Claims (MESC) derived for BAS. It identifies three phases of regulatory science consisting of the initial phase, when the regulators had to develop regulations without having the needed scientific information; the exploratory phase, when relevant tools were developed; and the standard operating phase, when the tools were applied to regulations. Subsequently, an attempt is made to apply the BAS/MESC system to various stages of LNT. This paper then compares the exposure limits imposed by regulatory agencies and also compares them with naturally occurring radiation at several cities. Controversies about LNT are addressed, including judgments of the U.S. National Academies and their French counterpart. The paper concludes that, based on the BAS/MESC system, there is no disagreement between the two academies on the scientific foundation of LNT; instead, the disagreement is based on their judgment or speculation.

Customisable Scientific Web Portal for Fusion Research

Energy Technology Data Exchange (ETDEWEB)

Abla, G; Kim, E; Schissel, D; Flannagan, S [General Atomics, San Diego (United States)

2009-07-01

The Web browser has become one of the major application interfaces for remotely participating in magnetic fusion. Web portals are used to present very diverse sources of information in a unified way. While a web portal has several benefits over other software interfaces, such as providing single point of access for multiple computational services, and eliminating the need for client software installation, the design and development of a web portal has unique challenges. One of the challenges is that a web portal needs to be fast and interactive despite a high volume of tools and information that it presents. Another challenge is the visual output on the web portal often is overwhelming due to the high volume of data generated by complex scientific instruments and experiments; therefore the applications and information should be customizable depending on the needs of users. An appropriate software architecture and web technologies can meet these problems. A web-portal has been designed to support the experimental activities of DIII-D researchers worldwide. It utilizes a multi-tier software architecture, and web 2.0 technologies, such as AJAX, Django, and Memcached, to develop a highly interactive and customizable user interface. It offers a customizable interface with personalized page layouts and list of services for users to select. Customizable services are: real-time experiment status monitoring, diagnostic data access, interactive data visualization. The web-portal also supports interactive collaborations by providing collaborative logbook, shared visualization and online instant message services. Furthermore, the web portal will provide a mechanism to allow users to create their own applications on the web portal as well as bridging capabilities to external applications such as Twitter and other social networks. In this series of slides, we describe the software architecture of this scientific web portal and our experiences in utilizing web 2.0 technologies. A

Evolution of the scientific paper

Energy Technology Data Exchange (ETDEWEB)

Harmon, J.E.

1992-09-01

The first papers reporting original research results in technical periodicals and proceedings appeared in the late 17th century. Since that time, the typical scientific paper has evolved from a fairly simple document, accessible to a general audience, to a much more complex one, aimed at a specialized audience. The purpose of this article is to give an overview of what the first scientific papers were like and how they evolved to their present form and style. To facilitate this discussion, the scientific paper`s development has arbitrarily been divided into four stages: the origin and formative years of the scientific paper (1665-1765), emergence of scientific papers written for specialized publications (1765-1865), development of the modem scientific paper (1865-1965), and hyperspecialization and computerization of the modem scientific paper (1965-?).

Evolution of the scientific paper

Energy Technology Data Exchange (ETDEWEB)

Harmon, J.E.

1992-01-01

The first papers reporting original research results in technical periodicals and proceedings appeared in the late 17th century. Since that time, the typical scientific paper has evolved from a fairly simple document, accessible to a general audience, to a much more complex one, aimed at a specialized audience. The purpose of this article is to give an overview of what the first scientific papers were like and how they evolved to their present form and style. To facilitate this discussion, the scientific paper's development has arbitrarily been divided into four stages: the origin and formative years of the scientific paper (1665-1765), emergence of scientific papers written for specialized publications (1765-1865), development of the modem scientific paper (1865-1965), and hyperspecialization and computerization of the modem scientific paper (1965- ).

The Adam and Eve Robot Scientists for the Automated Discovery of Scientific Knowledge

Science.gov (United States)

King, Ross

A Robot Scientist is a physically implemented robotic system that applies techniques from artificial intelligence to execute cycles of automated scientific experimentation. A Robot Scientist can automatically execute cycles of hypothesis formation, selection of efficient experiments to discriminate between hypotheses, execution of experiments using laboratory automation equipment, and analysis of results. The motivation for developing Robot Scientists is to better understand science, and to make scientific research more efficient. The Robot Scientist `Adam' was the first machine to autonomously discover scientific knowledge: both form and experimentally confirm novel hypotheses. Adam worked in the domain of yeast functional genomics. The Robot Scientist `Eve' was originally developed to automate early-stage drug development, with specific application to neglected tropical disease such as malaria, African sleeping sickness, etc. We are now adapting Eve to work with on cancer. We are also teaching Eve to autonomously extract information from the scientific literature.

GEO-6 project for Galileo data scientific utilization

Science.gov (United States)

Buresova, Dalia; Lastovicka, Jan; Boska, Josef; Sauli, Petra; Kouba, Daniel; Mosna, Zbysek

The future GNSS Galileo system offer a number of benefits (e.g. availability of better accuracy positioning, new frequencies bands allowing the implementation of specific techniques, provable time-stamp and location data using SIS authorisation, integrity, better support ad-hoc algorithms for data analysis and other service guarantee for liability and regulated applications) are widely spread among different disciplines. Also applications which are less interesting from the commercial and market point of view could successfully contribute to the numerous social benefits and support the innovation in the international research. The aim of the GEO-6 project "Scientific research Using GNSS" is to propose and broaden scientific utilization of future GNSS Galileo system data in research. It is a joint project of seven institutions from six countries led by the Atos Origin Company from Spain. The core of the project consists from six projects in five priority areas: PA-1 Remote sensing of the ocean using GNSS reflections, PA-2a Investigating GNSS ionospheric data assimilation, PA-2b 3-D gravity wave detection and determination (both PA-2a and PA-2b are ionospheric topics), PA-3 Demonstration of capability for operational forecasting of atmospheric delays, PA-4 GNSS seismometer, PA-5 Spacecraft formation flying using global navigation satellite systems. Institute of Atmospheric Physics, Prague, Czech Republic is responsible for the project PA-2b, where we developed and tested (to the extent allowed by available data) an algorithm and computer code for the 3-D detection of gravity waves and determination of their characteristics. The main drivers of the GEO-6 project are: high levels of accuracy even with the support of local elements, sharing of solutions and results for the worldwide scientific community. The paper will present basic description of the project with more details concerning Czech participation in it.

Turning Scientific Presentations into Stories

Science.gov (United States)

Aruffo, Christopher

2015-01-01

To increase students' confidence in giving scientific presentations, students were shown how to present scientific findings as a narrative story. Students who were preparing to give a scientific talk attended a workshop in which they were encouraged to experience the similarities between telling a personal anecdote and presenting scientific data.…

The ESA Scientific Exploitation of Operational Missions element

Science.gov (United States)

Desnos, Yves-Louis; Regner, Peter; Delwart, Steven; Benveniste, Jerome; Engdahl, Marcus; Zehner, Claus; Mathieu, Pierre-Philippe; Bojkov, Bojan; Gascon, Ferran; Donlon, Craig; Davidson, Malcolm; Goryl, Philippe; Pinnock, Simon

2015-04-01

SEOM is a program element within the fourth period (2013-2017) of ESA's Earth Observation Envelope Programme (http://seom.esa.int/). The prime objective is to federate, support and expand the international research community that the ERS,ENVISAT and the Envelope programmes have built up over the last 25 years. It aims to further strengthen the leadership of the European Earth Observation research community by enabling them to extensively exploit future European operational EO missions. SEOM will enable the science community to address new scientific research that are opened by free and open access to data from operational EO missions. Based on community-wide recommendations for actions on key research issues, gathered through a series of international thematic workshops and scientific user consultation meetings, a work plan has been established and is approved every year by ESA Members States. The 2015 SEOM work plan is covering the organisation of three Science users consultation workshops for Sentinel1/3/5P , the launch of new R&D studies for scientific exploitation of the Sentinels, the development of open-source multi-mission scientific toolboxes, the organisation of advanced international training courses, summer schools and educational materials, as well as activities for promoting the scientific use of EO data. The first SEOM projects have been tendered since 2013 including the development of Sentinel toolboxes, advanced INSAR algorithms for Sentinel-1 TOPS data exploitation, Improved Atmospheric Spectroscopic data-base (IAS), as well as grouped studies for Sentinel-1, -2, and -3 land and ocean applications and studies for exploiting the synergy between the Sentinels. The status and first results from these SEOM projects will be presented and an outlook for upcoming SEOM studies will be given.