WorldWideScience

Sample records for focusing isar images

  1. Using image quality measures and features to choose good images for classification of ISAR imagery

    CSIR Research Space (South Africa)

    Steyn, JM

    2014-10-01

    Full Text Available Most research efforts in ISAR focus on techniques to form the image via autofocus or on classification (assuming that the ISAR imagery is already generated). An important step between image formation and classification is to determine which...

  2. Sparse Bayesian learning in ISAR tomography imaging

    Institute of Scientific and Technical Information of China (English)

    SU Wu-ge; WANG Hong-qiang; DENG Bin; WANG Rui-jun; QIN Yu-liang

    2015-01-01

    Inverse synthetic aperture radar (ISAR) imaging can be regarded as a narrow-band version of the computer aided tomography (CT). The traditional CT imaging algorithms for ISAR, including the polar format algorithm (PFA) and the convolution back projection algorithm (CBP), usually suffer from the problem of the high sidelobe and the low resolution. The ISAR tomography image reconstruction within a sparse Bayesian framework is concerned. Firstly, the sparse ISAR tomography imaging model is established in light of the CT imaging theory. Then, by using the compressed sensing (CS) principle, a high resolution ISAR image can be achieved with limited number of pulses. Since the performance of existing CS-based ISAR imaging algorithms is sensitive to the user parameter, this makes the existing algorithms inconvenient to be used in practice. It is well known that the Bayesian formalism of recover algorithm named sparse Bayesian learning (SBL) acts as an effective tool in regression and classification, which uses an efficient expectation maximization procedure to estimate the necessary parameters, and retains a preferable property of thel0-norm diversity measure. Motivated by that, a fully automated ISAR tomography imaging algorithm based on SBL is proposed. Experimental results based on simulated and electromagnetic (EM) data illustrate the effectiveness and the superiority of the proposed algorithm over the existing algorithms.

  3. Ship dynamics for maritime ISAR imaging.

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2008-02-01

    Demand is increasing for imaging ships at sea. Conventional SAR fails because the ships are usually in motion, both with a forward velocity, and other linear and angular motions that accompany sea travel. Because the target itself is moving, this becomes an Inverse- SAR, or ISAR problem. Developing useful ISAR techniques and algorithms is considerably aided by first understanding the nature and characteristics of ship motion. Consequently, a brief study of some principles of naval architecture sheds useful light on this problem. We attempt to do so here. Ship motions are analyzed for their impact on range-Doppler imaging using Inverse Synthetic Aperture Radar (ISAR). A framework for analysis is developed, and limitations of simple ISAR systems are discussed.

  4. ISAR imaging using the instantaneous range instantaneous Doppler method

    CSIR Research Space (South Africa)

    Wazna, TM

    2015-10-01

    Full Text Available In Inverse Synthetic Aperture Radar (ISAR) imaging, the Range Instantaneous Doppler (RID) method is used to compensate for the nonuniform rotational motion of the target that degrades the Doppler resolution of the ISAR image. The Instantaneous Range...

  5. Sparse representation for the ISAR image reconstruction

    Science.gov (United States)

    Hu, Mengqi; Montalbo, John; Li, Shuxia; Sun, Ligang; Qiao, Zhijun G.

    2016-05-01

    In this paper, a sparse representation of the data for an inverse synthetic aperture radar (ISAR) system is provided in two dimensions. The proposed sparse representation motivates the use a of a Convex Optimization that recovers the image with far less samples, which is required by Nyquist-Shannon sampling theorem to increases the efficiency and decrease the cost of calculation in radar imaging.

  6. Distributed MIMO-ISAR Sub-image Fusion Method

    Directory of Open Access Journals (Sweden)

    Gu Wenkun

    2017-02-01

    Full Text Available The fast fluctuation associated with maneuvering a target’s radar cross-section often affects the imaging performance stability of traditional monostatic Inverse Synthetic Aperture Radar (ISAR. To address this problem, in this study, we propose an imaging method based on the fusion of sub-images of frequencydiversity-distributed multiple Input-Multiple Output-Inverse Synthetic Aperture Radar (MIMO-ISAR. First, we establish the analytic expression of a two-dimensional ISAR sub-image acquired by different channels of distributed MIMO-ISAR. Then, we derive the distance and azimuth distortion factors of the image acquired by the different channels. By compensating for the distortion of the ISAR image, we ultimately realize distributed MIMO-ISAR fusion imaging. Simulations verify the validity of this imaging method using distributed MIMO-ISAR.

  7. Solution of Phase Compensation Problems for ISAR Imaging

    Institute of Scientific and Technical Information of China (English)

    QIUXiaohui; ZHAOYang; HENGWangChengAlice

    2005-01-01

    Solution of phase compensation for Inverse synthetic aperture radar (ISAR) imaging has been analyzed in classification, including maximum likelihoodbased phase compensation and minimum entropy-based phase compensation. Further, it is proved in paper that minimum entropy method actually is not an optimal solution since its extreme small value is only a local extremum. Also comparison between two type methods has been done for real ISAR data processing together with discussion on characteristics of phase compensation for those methods in this paper. Results show that minimum entropy method has better focusing than maximum likelihood method, however, it is with huge computation work.

  8. Research on THz stepped-frequency ISAR imaging

    Science.gov (United States)

    Liang, Meiyan; Zhang, Zhiheng; Zhang, Cunlin

    2016-11-01

    High resolution THz inverse synthetic aperture radar (ISAR) imaging for the aircraft is simulated using 0.22THz stepped-frequency (SF) radar system which is designed in the paper. Based on the small rotate angle and the far field approximation, the Range-Doppler algorithm is proposed to reconstruct THz ISAR image of the aircraft. The simulation results indicate that THz stepped-frequency radar can achieve high resolution ISAR images of the aircraft, the resolution of the ISAR images can reach centimeter-scale, which laid a theoretical foundation for radar imaging in THz band.

  9. ISAR Echoes Coherent Processing and Imaging

    Institute of Scientific and Technical Information of China (English)

    XINGMengdao; LANJinqiao; BAOZheng; LIAOGuisheng

    2004-01-01

    The general approach to ISAR imaging is Range-doppler (RD) imaging approach. For this approach,the Translational motion compensation (TMC) is firstly obtained by envelope alignment and autofocus, so the target can be treated as a rotating target for the next processing. But in this method, scatterers' Migration through resolution cells (MTRC) caused by rotational motion is neglected. However in practice, MTRC exists with the improvement of resolution or for big target. For MTRC compensation, the keystone transformation in SAR is used inthis paper. Before the keystone transformation, it is demanded that the rawdata is coherent, while in fact, the ISAR rawdata is usually not. So a coherent processing of rawdata is proposed. In this paper, the coherent processing of rawdata is firstly done and the next step is to correct MTRC. After using multi-component Amplitude modulation and Linear frequency modulation (AM-LFM) parameter estimation method, the Range-Instantaneous Doppler(RID) ISAR image is obtained. The effectiveness of this algorithm is validated by the processing of simulation data.

  10. Coherent processing for ISAR imaging with sparse apertures

    Institute of Scientific and Technical Information of China (English)

    SHENG JiaLian; ZHANG Lei; XU Gang; XING MengDao; BAO Zheng

    2012-01-01

    To implement target detection,tracking and imaging in a multifunctional radar system,the wideband measurements for inverse synthetic aperture radar (ISAR) imaging are usually sparsely recorded.Considering the incoherence problem in such sparse-aperture ISAR (SA-ISAR) systems,we concentrate on the study of a coherent processing method in this work.Based on an all-pole model,the incoherence parameters between abutting sub-apertures can be effectively estimated.After coherence compensation,an optimization-based SA-ISAR imaging approach is provided from the view of statistics.Simulation and real data experiments validate the feasibility and effectiveness of the proposals.

  11. Classification of Targets in SAR Images Using ISAR Data

    NARCIS (Netherlands)

    Wit, J.J.M. de; Dekker, R.J.; Broek, A.C. van den

    2005-01-01

    Feature-based classification of targets in SAR images by using ISAR measurements was studied, based on polarimetric SAR and ISAR data acquired with the MEMPHIS radar system of FGAN-FHR. The data contained one T-72 battle tank, one BMP combat vehicle, and several confusers. The resolution was 75 cm.

  12. OFDM-ISAR Sparse Optimization Imaging and Motion Compensation

    Directory of Open Access Journals (Sweden)

    Wu Min

    2016-02-01

    Full Text Available Orthogonal Frequency Division Multiplexing (OFDM technology has been utilized in radar imaging to obtain high-resolution range profiles without inter-range cell interference. In this study, we establish a novel algorithm for Inverse Synthetic Aperture Radar (ISAR imaging of a non-cooperative target using OFDM waveforms. We also achieve motion compensation and image enhancement with sparse reconstruction optimization. Utilizing sparse reconstruction optimization, we can simultaneously achieve high-precision OFDM-ISAR imaging and also correct phase errors. Extensive experimentation confirms that the proposed method can effectively overcome range interference and phase errors in OFDM-ISAR imaging, providing optimal robustness and precision.

  13. ISAR Imaging of Maneuvering Targets Based on the Modified Discrete Polynomial-Phase Transform

    Directory of Open Access Journals (Sweden)

    Yong Wang

    2015-09-01

    Full Text Available Inverse synthetic aperture radar (ISAR imaging of a maneuvering target is a challenging task in the field of radar signal processing. The azimuth echo can be characterized as a multi-component polynomial phase signal (PPS after the translational compensation, and the high quality ISAR images can be obtained by the parameters estimation of it combined with the Range-Instantaneous-Doppler (RID technique. In this paper, a novel parameters estimation algorithm of the multi-component PPS with order three (cubic phase signal-CPS based on the modified discrete polynomial-phase transform (MDPT is proposed, and the corresponding new ISAR imaging algorithm is presented consequently. This algorithm is efficient and accurate to generate a focused ISAR image, and the results of real data demonstrate the effectiveness of it.

  14. ISAR imaging based on sparse subbands fusion

    Science.gov (United States)

    Li, Gang; Tian, Biao; Xu, Shiyou; Chen, Zengping

    2015-12-01

    Data fusion using subbands, which can obtain a higher range resolution without altering the bandwidth, hardware, and sampling rate of the radar system, has attracted more and more attention in recent years. A method of ISAR imaging based on subbands fusion and high precision parameter estimation of geometrical theory of diffraction (GTD) model is presented in this paper. To resolve the incoherence problem in subbands data, a coherent processing method is adopted. Based on an all-pole model, the phase difference of pole and scattering coefficient between each sub-band is used to effectively estimate the incoherent components. After coherent processing, the high and low frequency sub-band data can be expressed as a uniform all-pole model. The gapped-data amplitude and phase estimation (GAPES) algorithm is used to fill up the gapped band. Finally, fusion data is gained by high precision parameter estimation of GTD-all-pole model with full-band data, such as scattering center number, scattering center type and amplitude. The experimental results of simulated data show the validity of the algorithm.

  15. Polarimetric ISAR: Simulation and image reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, David H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-03-21

    In polarimetric ISAR the illumination platform, typically airborne, carries a pair of antennas that are directed toward a fixed point on the surface as the platform moves. During platform motion, the antennas maintain their gaze on the point, creating an effective aperture for imaging any targets near that point. The interaction between the transmitted fields and targets (e.g. ships) is complicated since the targets are typically many wavelengths in size. Calculation of the field scattered from the target typically requires solving Maxwell’s equations on a large three-dimensional numerical grid. This is prohibitive to use in any real-world imaging algorithm, so the scattering process is typically simplified by assuming the target consists of a cloud of independent, non-interacting, scattering points (centers). Imaging algorithms based on this scattering model perform well in many applications. Since polarimetric radar is not very common, the scattering model is often derived for a scalar field (single polarization) where the individual scatterers are assumed to be small spheres. However, when polarization is important, we must generalize the model to explicitly account for the vector nature of the electromagnetic fields and its interaction with objects. In this note, we present a scattering model that explicitly includes the vector nature of the fields but retains the assumption that the individual scatterers are small. The response of the scatterers is described by electric and magnetic dipole moments induced by the incident fields. We show that the received voltages in the antennas are linearly related to the transmitting currents through a scattering impedance matrix that depends on the overall geometry of the problem and the nature of the scatterers.

  16. Target Identification Using Harmonic Wavelet Based ISAR Imaging

    Science.gov (United States)

    Shreyamsha Kumar, B. K.; Prabhakar, B.; Suryanarayana, K.; Thilagavathi, V.; Rajagopal, R.

    2006-12-01

    A new approach has been proposed to reduce the computations involved in the ISAR imaging, which uses harmonic wavelet-(HW) based time-frequency representation (TFR). Since the HW-based TFR falls into a category of nonparametric time-frequency (T-F) analysis tool, it is computationally efficient compared to parametric T-F analysis tools such as adaptive joint time-frequency transform (AJTFT), adaptive wavelet transform (AWT), and evolutionary AWT (EAWT). Further, the performance of the proposed method of ISAR imaging is compared with the ISAR imaging by other nonparametric T-F analysis tools such as short-time Fourier transform (STFT) and Choi-Williams distribution (CWD). In the ISAR imaging, the use of HW-based TFR provides similar/better results with significant (92%) computational advantage compared to that obtained by CWD. The ISAR images thus obtained are identified using a neural network-based classification scheme with feature set invariant to translation, rotation, and scaling.

  17. ISAR Image Formation Using Sequential Minimization of L0 and L2 Norms

    CERN Document Server

    Li, Gang; Wang, Xiqin; Xia, Xiang-Gen

    2012-01-01

    A sparsity-driven algorithm of inverse synthetic aperture radar (ISAR) imaging is proposed. Based on the parametric sparse representation of the received ISAR signal, the problem of ISAR image formation is converted into the joint estimation of the target rotation rate and the sparse power distribution in the spatial domain. This goal is achieved by sequential minimization of L0 and L2 norms, which ensure the sparsest ISAR image and the minimum recovery error, respectively.

  18. Quality measures for HRR alignment based ISAR imaging algorithms

    CSIR Research Space (South Africa)

    Janse van Rensburg, V

    2013-05-01

    Full Text Available Some Inverse Synthetic Aperture Radar (ISAR) algorithms form the image in a two-step process of range alignment and phase conjugation. This paper discusses a comprehensive set of measures used to quantify the quality of range alignment, with the aim...

  19. Spindle extraction method for ISAR image based on Radon transform

    Science.gov (United States)

    Wei, Xia; Zheng, Sheng; Zeng, Xiangyun; Zhu, Daoyuan; Xu, Gaogui

    2015-12-01

    In this paper, a method of spindle extraction of target in inverse synthetic aperture radar (ISAR) image is proposed which depends on Radon Transform. Firstly, utilizing Radon Transform to detect all straight lines which are collinear with these line segments in image. Then, using Sobel operator to detect image contour. Finally, finding all intersections of each straight line and image contour, the two intersections which have maximum distance between them is the two ends of this line segment and the longest line segment of all line segments is spindle of target. According to the proposed spindle extraction method, one hundred simulated ISAR images which are respectively rotated 0 degrees, 10 degrees, 20 degrees, 30 degrees and 40 degrees in counterclockwise are used to do experiment and the proposed method and the detection results are more close to the real spindle of target than the method based on Hough Transform .

  20. MTRC compensation in high-resolution ISAR imaging via improved polar format algorithm

    Science.gov (United States)

    Liu, Yang; Li, Hao; Li, Na; Xu, Shiyou; Chen, Zengping

    2014-10-01

    Migration through resolution cells (MTRC) is generated in high-resolution inverse synthetic aperture radar (ISAR) imaging. A MTRC compensation algorithm for high-resolution ISAR imaging based on improved polar format algorithm (PFA) is proposed in this paper. Firstly, in the situation that a rigid-body target stably flies, the initial value of the rotation angle and center of the target is obtained from the rotation of radar line of sight (RLOS) and high range resolution profile (HRRP). Then, the PFA is iteratively applied to the echo data to search the optimization solution based on minimum entropy criterion. The procedure starts with the estimated initial rotation angle and center, and terminated when the entropy of the compensated ISAR image is minimized. To reduce the computational load, the 2-D iterative search is divided into two 1-D search. One is carried along the rotation angle and the other one is carried along rotation center. Each of the 1-D searches is realized by using of the golden section search method. The accurate rotation angle and center can be obtained when the iterative search terminates. Finally, apply the PFA to compensate the MTRC by the use of the obtained optimized rotation angle and center. After MTRC compensation, the ISAR image can be best focused. Simulated and real data demonstrate the effectiveness and robustness of the proposed algorithm.

  1. Resolution enhancement for ISAR imaging via improved statistical compressive sensing

    Science.gov (United States)

    Zhang, Lei; Wang, Hongxian; Qiao, Zhi-jun

    2016-12-01

    Developing compressed sensing (CS) theory reveals that optimal reconstruction of an unknown signal can be achieved from very limited observations by utilizing signal sparsity. For inverse synthetic aperture radar (ISAR), the image of an interesting target is generally constructed by limited strong scattering centers, representing strong spatial sparsity. Such prior sparsity intrinsically paves a way to improved ISAR imaging performance. In this paper, we develop a super-resolution algorithm for forming ISAR images from limited observations. When the amplitude of the target scattered field follows an identical Laplace probability distribution, the approach converts super-resolution imaging into sparsity-driven optimization in the Bayesian statistics sense. We show that improved performance is achievable by taking advantage of the meaningful spatial structure of the scattered field. Further, we use the nonidentical Laplace distribution with small scale on strong signal components and large scale on noise to discriminate strong scattering centers from noise. A maximum likelihood estimator combined with a bandwidth extrapolation technique is also developed to estimate the scale parameters. Real measured data processing indicates the proposal can reconstruct the high-resolution image though only limited pulses even with low SNR, which shows advantages over current super-resolution imaging methods.

  2. Target rotation parameter estimation for ISAR imaging via frame processing

    Institute of Scientific and Technical Information of China (English)

    Xuezhi Wang; Yajing Huang; Weiping Yang; Bill Moran

    2016-01-01

    Frame processing method offers a model-based approach to Inverse Synthetic Aperture Radar (ISAR) imaging. It also provides a way to estimate the rotation rate of a non-cooperative target from radar returns via the frame operator properties. In this paper, the relationship between the best achievable ISAR image and the reconstructed image from radar returns was derived in the framework of Finite Frame Processing theory. We show that image defocusing caused by the use of an incorrect target rotation rate is interpreted under the FP method as a frame operator mismatch problem which causes energy dispersion. The unknown target rotation rate may be computed by optimizing the frame operator via a prominent point. Consequently, a prominent intensity maximization method in FP framework was proposed to estimate the underlying target rotation rate from radar returns. In addition, an image filtering technique was implemented to assist searching for a prominent point in practice. The proposed method is justified via a simulation analysis on the performance of FP imaging versus target rotation rate error. Effectiveness of the proposed method is also confirmed from real ISAR data experiments.

  3. Optimal ship imaging for shore-based ISAR using DCF estimation

    Institute of Scientific and Technical Information of China (English)

    Ling Wang; Zhenxiao Cao; Ning Li; Teng Jing; Daiyin Zhu

    2015-01-01

    The optimal imaging time selection of ship targets for shore-based inverse synthetic aperture radar (ISAR) in high sea conditions is investigated. The optimal imaging time includes opti-mal imaging instants and optimal imaging duration. A novel method for optimal imaging instants selection based on the estimation of the Doppler centroid frequencies (DCFs) of a series of images obtained over continuous short durations is proposed. Combined with the optimal imaging duration selection scheme using the image contrast maximization criteria, this method can provide the ship images with the highest focus. Simulated and real data pro-cessing results verify the effectiveness of the proposed imaging method.

  4. ISAR Imaging Using Fourier and Wavelet Transforms

    Science.gov (United States)

    2007-12-01

    for i=1:45; Imf2=SFABS(1,:,i); Image2=[Image2;Imf2]; end 60 LIST OF REFERENCES [1] George Arfken . Mathematical Methods for Physicists, volume Third...arcs that can be approximated as lines. Consequently, the imaging method is mathematically the same as that used in Inverse Synthetic Aperture Radar...and why it’s not a good approach to our problem. We investigate the results using this time-frequency methods , creating images using synthetic data

  5. Experimental 0.22 THz Stepped Frequency Radar System for ISAR Imaging

    Science.gov (United States)

    Liang, Mei Yan; Zhang, Cun Lin; Zhao, Ran; Zhao, Yue Jin

    2014-09-01

    High resolution inverse synthetic aperture radar (ISAR) imaging is demonstrated by using a 0.22 THz stepped-frequency (SF) imaging radar system. The synthesis bandwidth of the terahertz (THz) SF radar is 12 GHz, which are beneficial for high resolution imaging. The resolution of ISAR image can reach centimeter-scale with the use of Range-Doppler algorithm (RDA). Results indicate that high resolution ISAR imaging is realized by using 0.22THz SF radar coupled with turntable scanning, which can provide foundations for further research on high-resolution radar image in the THz band.

  6. New Compressed Sensing ISAR Imaging Algorithm Based on Log-Sum Minimization

    Science.gov (United States)

    Ping, Cheng; Jiaqun, Zhao

    2016-12-01

    To improve the performance of inverse synthetic aperture radar (ISAR) imaging based on compressed sensing (CS), a new algorithm based on log-sum minimization is proposed. A new interpretation of the algorithm is also provided. Compared with the conventional algorithm, the new algorithm can recover signals based on fewer measurements, in looser sparsity condition, with smaller recovery error, and it has obtained better sinusoidal signal spectrum and imaging result for real ISAR data. Therefore, the proposed algorithm is a promising imaging algorithm in CS ISAR.

  7. Multiple Measurement Vectors ISAR Imaging Algorithm Based on a Class of Linearized Bregman Iteration

    Directory of Open Access Journals (Sweden)

    Chen Wenfeng

    2016-08-01

    Full Text Available This study aims to enable steady and speedy acquisition of Inverse Synthetic Aperture Radar (ISAR images using sparse echo data. To this end, a Multiple Measurement Vectors (MMV ISAR echo model is studied. This model is then combined with the Compressive Sensing (CS theory to realize a class of MMV fast ISAR imaging algorithms based on the Linearized Bregman Iteration (LBI. The algorithms involve four methods, and the iterative framework, application conditions, and relationship between the four methods are given. The reconstructed performance of the methods, convergence, anti-noise, and selection of regularization parameters are then compared and analyzed comprehensively. Finally, the experimental results are compared with the traditional Single Measurement Vector (SMV ISAR imaging algorithm; this comparison shows that the proposed algorithm delivers an improved imaging quality with a low Signal-to-Noise Ratio (SNR.

  8. ISAR Imaging Based on Sparse Chaotic Sequence Measurement Matrices%基于混沌序列稀疏化测量矩阵的 ISAR 成像

    Institute of Scientific and Technical Information of China (English)

    谭歆; 冯晓毅; 王保平; 程伟; 方阳

    2016-01-01

    The construction of measurement matrices is one of the core tasks in compressed sensing inverse synthe-tic aperture radar ( ISAR) imaging.The chaotic sequence measurement matrices are of excellent pseudo-random-ness, which can meet the requirements of compressive measurement.As it is difficult to implement the hardware engineering of the chaotic sequence measurement matrices because of the huge number of independent random ele-ments, a construction method of sparse chaotic sequence measurement matrices is proposed in this paper.In the method, the chaotic sequence measurement matrices are optimized, and then setting the zero along the diagonal di-rection is performed to make the matrix sparse.Finally, the sparse chaotic sequence measurement matrices are used to conduct ISAR imaging experiments in a microwave anechoic chamber.The results show that, in comparison with the Gauss random matrix imaging method, the proposed method achieves an accurate focusing of ISAR imaging and reduces the computational complexity and the hardware implementation difficulty.%在压缩感知逆合成孔径雷达( ISAR )成像中,构造测量矩阵是核心工作之一。混沌序列测量矩阵具有良好的伪随机性,能满足压缩测量的要求。针对混沌序列测量矩阵中非零随机元数目多而造成硬件实现困难的问题,文中提出了一种混沌序列稀疏化测量矩阵的构造方法。首先对混沌序列测量矩阵进行优化,然后沿矩阵对角方向进行置零稀疏化,最后将其应用于微波暗室进行ISAR成像实验。结果表明,与传统高斯随机矩阵成像方法相比,文中方法在降低计算复杂度、硬件实现难度基础上达到了ISAR成像的准确聚焦。

  9. Simultaneous ISAR imaging of group targets flying in formation

    Institute of Scientific and Technical Information of China (English)

    Chen Jie; Xiao Huaitie; Song Zhiyong; Fan Hongqi

    2014-01-01

    This paper proposes a novel inverse synthetic aperture radar (ISAR) imaging method based on second-order keystone transform (KT) and Sandglass transform for group targets flying in a formation with constant accelerated rectilinear motion in the same radar beam. First, range cur-vature and range walk of each sub-target among group targets are corrected by the second-order KT combined with the quadratic phase term compensation. After range alignment, the signals in each range frequency cell can be modelled as multiple chirp signals and then the Sandglass transform is uti-lized to cross-range imaging, which transforms the time–frequency distribution of the signals in each range frequency cell into beelines parallel to the slow time axis simultaneously. Finally, cross-range profiles of group targets in each range frequency cell are obtained via a projection of the perk of every scatterer in the two-dimensional accumulation plane onto the frequency axis. The advantage of the proposed method is that it can align range profiles of each sub-target simultaneously and image cross-range profiles directly without separating the returned signals, which simplifies the operation procedure. Simulation results are used to demonstrate the effectiveness of the proposed method.

  10. Simultaneous ISAR imaging of group targets flying in formation

    Directory of Open Access Journals (Sweden)

    Chen Jie

    2014-12-01

    Full Text Available This paper proposes a novel inverse synthetic aperture radar (ISAR imaging method based on second-order keystone transform (KT and Sandglass transform for group targets flying in a formation with constant accelerated rectilinear motion in the same radar beam. First, range curvature and range walk of each sub-target among group targets are corrected by the second-order KT combined with the quadratic phase term compensation. After range alignment, the signals in each range frequency cell can be modelled as multiple chirp signals and then the Sandglass transform is utilized to cross-range imaging, which transforms the time–frequency distribution of the signals in each range frequency cell into beelines parallel to the slow time axis simultaneously. Finally, cross-range profiles of group targets in each range frequency cell are obtained via a projection of the perk of every scatterer in the two-dimensional accumulation plane onto the frequency axis. The advantage of the proposed method is that it can align range profiles of each sub-target simultaneously and image cross-range profiles directly without separating the returned signals, which simplifies the operation procedure. Simulation results are used to demonstrate the effectiveness of the proposed method.

  11. Aircraft target identification based on 2D ISAR images using multiresolution analysis wavelet

    Science.gov (United States)

    Fu, Qiang; Xiao, Huaitie; Hu, Xiangjiang

    2001-09-01

    The formation of 2D ISAR images for radar target identification hold much promise for additional distinguish- ability between targets. Since an image contains important information is a wide range of scales, and this information is often independent from one scale to another, wavelet analysis provides a method of identifying the spatial frequency content of an image and the local regions within the image where those spatial frequencies exist. In this paper, a multiresolution analysis wavelet method based on 2D ISAR images was proposed for use in aircraft radar target identification under the wide band high range resolution radar background. The proposed method was performed in three steps; first, radar backscatter signals were processed in the form of 2D ISAR images, then, Mallat's wavelet algorithm was used in the decomposition of images, finally, a three layer perceptron neural net was used as classifier. The result of experiments demonstrated that the feasibility of using multiresolution analysis wavelet for target identification.

  12. ISAR Imaging of Ship Targets Based on an Integrated Cubic Phase Bilinear Autocorrelation Function

    Directory of Open Access Journals (Sweden)

    Jibin Zheng

    2017-03-01

    Full Text Available For inverse synthetic aperture radar (ISAR imaging of a ship target moving with ocean waves, the image constructed with the standard range-Doppler (RD technique is blurred and the range-instantaneous-Doppler (RID technique has to be used to improve the image quality. In this paper, azimuth echoes in a range cell of the ship target are modeled as noisy multicomponent cubic phase signals (CPSs after the motion compensation and a RID ISAR imaging algorithm is proposed based on the integrated cubic phase bilinear autocorrelation function (ICPBAF. The ICPBAF is bilinear and based on the two-dimensionally coherent energy accumulation. Compared to five other estimation algorithms, the ICPBAF can acquire higher cross term suppression and anti-noise performance with a reasonable computational cost. Through simulations and analyses with the synthetic model and real radar data, we verify the effectiveness of the ICPBAF and corresponding RID ISAR imaging algorithm.

  13. Terahertz ISAR and x-ray imaging of wind turbine blade structures

    Science.gov (United States)

    Martin, Robert; Baird, Christopher S.; Giles, Robert H.; Niezrecki, Christopher

    2016-04-01

    During the manufacture of wind turbine blades, internal defects can form which negatively affect their structural integrity and may lead to premature failure. The purpose of this research was to conduct preliminary testing of nondestructive evaluation techniques that have the potential to scale up to larger areas. The techniques investigated were: Terahertz frequency fully-polarimetric inverse synthetic aperture radar (ISAR), and x-ray imaging. The terahertz ISAR technique employed standard polarimetric radar cross-section processing, and additionally applied an optimized polarimetry transformation known as the Euler transformation. Also, image back-rotation and compositing algorithms were used to combine multiple ISAR images into a single image to aid in defect detection. ISAR data were collected using a frequency modulated continuous wave 100 GHz radar system. The x-ray technique utilized a commercial airport cargo x-ray scanner. Multiple fiberglass samples with defects representative of manufacturing wind turbine blade defects were investigated using each of the techniques. Out-of-plane defects and resin dry patches were the primary defects of interest in these samples. Images were created of each sample using each of the techniques. Comparing these images with defect diagrams of the samples indicated that these techniques could effectively indicate the presence of certain defects.

  14. Research on spatial-variant property of bistatic ISAR imaging plane of space target

    Science.gov (United States)

    Guo, Bao-Feng; Wang, Jun-Ling; Gao, Mei-Guo

    2015-04-01

    The imaging plane of inverse synthetic aperture radar (ISAR) is the projection plane of the target. When taking an image using the range-Doppler theory, the imaging plane may have a spatial-variant property, which causes the change of scatter’s projection position and results in migration through resolution cells. In this study, we focus on the spatial-variant property of the imaging plane of a three-axis-stabilized space target. The innovative contributions are as follows. 1) The target motion model in orbit is provided based on a two-body model. 2) The instantaneous imaging plane is determined by the method of vector analysis. 3) Three Euler angles are introduced to describe the spatial-variant property of the imaging plane, and the image quality is analyzed. The simulation results confirm the analysis of the spatial-variant property. The research in this study is significant for the selection of the imaging segment, and provides the evidence for the following data processing and compensation algorithm. Project supported by the National Natural Science Foundation of China (Grant No. 61401024), the Shanghai Aerospace Science and Technology Innovation Foundation, China (Grant No. SAST201240), and the Basic Research Foundation of Beijing Institute of Technology (Grant No. 20140542001).

  15. Research on spatial-variant property of bistatic ISAR imaging plane of space target

    Institute of Scientific and Technical Information of China (English)

    郭宝锋; 王俊岭; 高梅国; 尚朝轩; 傅雄军

    2015-01-01

    The imaging plane of inverse synthetic aperture radar (ISAR) is the projection plane of the target. When taking an image using the range-Doppler theory, the imaging plane may have a spatial-variant property, which causes the change of scatter’s projection position and results in migration through resolution cells. In this study, we focus on the spatial-variant property of the imaging plane of a three-axis-stabilized space target. The innovative contributions are as follows. 1) The target motion model in orbit is provided based on a two-body model. 2) The instantaneous imaging plane is determined by the method of vector analysis. 3) Three Euler angles are introduced to describe the spatial-variant property of the imaging plane, and the image quality is analyzed. The simulation results confirm the analysis of the spatial-variant property. The research in this study is significant for the selection of the imaging segment, and provides the evidence for the following data processing and compensation algorithm.

  16. Investigation of 3-D RCS Image formation of ships using ISAR

    CSIR Research Space (South Africa)

    Lord, RT

    2006-05-01

    Full Text Available Conventional Inverse Synthetic Aperture Radar (ISAR) utilises the rotational motion of a target such as a ship or an aircraft to obtain a 2-D image of the target’s radar cross section (RCS) profile from a coherent radar system. This concept can...

  17. Subinteger Range-Bin Alignment Method for ISAR Imaging of Noncooperative Targets

    Directory of Open Access Journals (Sweden)

    Pérez-Martínez F

    2010-01-01

    Full Text Available Inverse Synthetic Aperture Radar (ISAR is a coherent radar technique capable of generating images of noncooperative targets. ISAR may have better performance in adverse meteorological conditions than traditional imaging sensors. Unfortunately, ISAR images are usually blurred because of the relative motion between radar and target. To improve the quality of ISAR products, motion compensation is necessary. In this context, range-bin alignment is the first step for translational motion compensation. In this paper, we propose a subinteger range-bin alignment method based on envelope correlation and reference profiles. The technique, which makes use of a carefully designed optimization stage, is robust against noise, clutter, target scintillation, and error accumulation. It provides us with very fine translational motion compensation. Comparisons with state-of-the-art range-bin alignment methods are included and advantages of the proposal are highlighted. Simulated and live data from a high-resolution linear-frequency-modulated continuous-wave radar are included to perform the pertinent comparisons.

  18. Two-dimensional Length Extraction of Ballistic Target from ISAR Images Using a New Scaling Method by Affine Registration

    Directory of Open Access Journals (Sweden)

    Jin Guanghu

    2014-09-01

    Full Text Available The length of ballistic target is one of the most important features for target recognition. It can be extracted from ISAR Images. Unlike from the optical image, the length extraction from ISAR image has two difficulties. The first one is that it is hard to get the actual position of scattering centres by the traditional target extraction method. The second one is that the ISAR image’s cross scale is not known because of the target’s complex rotation. Here we propose two methods to solve these problems. Firstly, we use clustering method to get scattering centers. Secondly we propose to get cross scale of the ISAR images by affine registration. Experiments verified that our approach is realisable and has good performance.Defence Science Journal, Vol. 64, No. 5, September 2014, pp.458-463, DOI:http://dx.doi.org/10.14429/dsj.64.5001

  19. A Novel Speed Compensation Method for ISAR Imaging with Low SNR

    Directory of Open Access Journals (Sweden)

    Yongxiang Liu

    2015-07-01

    Full Text Available In this paper, two novel speed compensation algorithms for ISAR imaging under a low signal-to-noise ratio (SNR condition have been proposed, which are based on the cubic phase function (CPF and the integrated cubic phase function (ICPF, respectively. These two algorithms can estimate the speed of the target from the wideband radar echo directly, which breaks the limitation of speed measuring in a radar system. With the utilization of non-coherent accumulation, the ICPF-based speed compensation algorithm is robust to noise and can meet the requirement of speed compensation for ISAR imaging under a low SNR condition. Moreover, a fast searching implementation strategy, which consists of coarse search and precise search, has been introduced to decrease the computational burden of speed compensation based on CPF and ICPF. Experimental results based on radar data validate the effectiveness of the proposed algorithms.

  20. "Phase-Enhanced" 3D Snapshot ISAR Imaging and Interferometric SAR

    Science.gov (United States)

    2009-12-28

    contained in the two nearly identical in amplitude data sets. References [5-7] provide a good discussion of the basic principles and associated radar ... Interferometrie SAR J.T. Mayhan Group 32 Technical Report ] 135 28 December 2()(W Approved for public release; distribution is unlimited. Lexington...inverse synthetie aperture radar (ISAR) images based on recent developments in high resolution spectral estimation theory. Because this technique requires

  1. A novel cognitive ISAR imaging method with random stepped frequency chirp signal

    Institute of Scientific and Technical Information of China (English)

    ZHU Feng; ZHANG Qun; LUO Ying; LI KaiMing; GU FuFei

    2012-01-01

    The random stepped frequency chirp signal (RSFCS) has better performance in anti-jamming than that of conventional stepped frequency chirp signal (SFCS).In combination with the theory of compressing sensing (CS),a novel ISAR imaging method is proposed based on RSFCS,in which the high resolution range profile (HRRP) is reconstructed by using the conventional OMP algorithm,whereas the cognitive approach is introduced to further reduce the number of sub-pulse in RSFCS.In the proposed method,via cognizing the characteristics of moving targets,the number of sub-pulse in each burst can be adjusted adaptively.Finally,in the cross-range direction,the accurate reconstruction of ISAR image by using CS theory is implemented,which can effectively accomplish unwrapping.With the proposed method,high quality HRRP and ISAR image can be achieved with fewer sub-pulses of RSFCS and lower burst repetition frequency (BRF).Some simulation results are given to validate the effectiveness and robustness of the proposed algorithm.

  2. CLEAN Technique for Polarimetric ISAR

    Directory of Open Access Journals (Sweden)

    M. Martorella

    2008-01-01

    Full Text Available Inverse synthetic aperture radar (ISAR images are often used for classifying and recognising targets. To reduce the amount of data processed by the classifier, scattering centres are extracted from the ISAR image and used for classifying and recognising targets. This paper addresses the problem of estimating the position and the scattering vector of target scattering centres from polarimetric ISAR images. The proposed technique is obtained by extending the CLEAN technique, which was introduced in radar imaging for extracting scattering centres from single-polarisation ISAR images. The effectiveness of the proposed algorithm, namely, the Polarimetric CLEAN (Pol-CLEAN is tested on simulated and real data.

  3. ISAR Imaging of High-Speed Maneuvering Target Using Gapped Stepped-Frequency Waveform and Compressive Sensing.

    Science.gov (United States)

    Kang, Min-Seok; Lee, Seung-Jae; Lee, Seong-Hyeon; Kim, Kyung-Tae

    2017-07-17

    In the case of a stepped-frequency waveform (SFW) inverse synthetic aperture radar (ISAR) system, the translational motion (TM) of a target can be usually divided into two parts: 1) target motion within a pulse repetition interval (PRI), called the inter-pulse translational motion (IPTM) and 2) target motion between bursts, called the inter-burst translational motion (IBTM). The former induces severe blurring in the ISAR images as well as range-compressed data (i.e., range profile), and the latter also causes dramatic degradation of the ISAR image quality. In this paper, a novel framework for high-resolution gapped SFW (GSFW) ISAR imaging of high-speed maneuvering target is proposed. The main novelty of the proposed method is twofold: 1) accurate TM parameter estimation in conjunction with a compressive sensing theory using a newly devised cost function and particle swarm optimization and 2) compensation for both the IPTM and IBTM phase errors simultaneously even with the GSFW dataset. Simulation results using ideal point scatterers show that the proposed method is capable of precise reconstruction of ISAR image and accurate TM parameter estimation. Experimental results using real measured data verify the robustness and the effectiveness of the proposed method.

  4. 跟踪雷达的ISAR成像技术%ISAR Imaging Technology of Tracking Radar

    Institute of Scientific and Technical Information of China (English)

    高环

    2015-01-01

    ISAR imaging technology of tracking radar is presented in this paper, the specialty of the tracking radar imaging is analyzed and the motion compensation, range-walk correction and orientation imaging are deeply studied. Finally, the effectiveness of the proposed method by data processing is verified.%本文对跟踪雷达的ISAR成像技术进行了研究。对跟踪雷达的成像特殊性进行了分析,并对成像中涉及的运动补偿、距离走动校正以及方位成像进行了深入研究,最后通过数据处理对所提方法的有效性进行了验证。

  5. Investigating the effect of a targets time-varying doppler generating axis of rotation on isar image distortion

    CSIR Research Space (South Africa)

    Abdul Gaffar, MY

    2007-10-01

    Full Text Available in ISAR imaging mostly under the limited assumption that a targets axis of rotation is constant over the CPI. This paper investigates how the targets time-varying Doppler generating axis of rotation, caused by the complex 3D motion of a target at sea...

  6. Supervised Self-Organizing Classification of Superresolution ISAR Images: An Anechoic Chamber Experiment

    Directory of Open Access Journals (Sweden)

    Radoi Emanuel

    2006-01-01

    Full Text Available The problem of the automatic classification of superresolution ISAR images is addressed in the paper. We describe an anechoic chamber experiment involving ten-scale-reduced aircraft models. The radar images of these targets are reconstructed using MUSIC-2D (multiple signal classification method coupled with two additional processing steps: phase unwrapping and symmetry enhancement. A feature vector is then proposed including Fourier descriptors and moment invariants, which are calculated from the target shape and the scattering center distribution extracted from each reconstructed image. The classification is finally performed by a new self-organizing neural network called SART (supervised ART, which is compared to two standard classifiers, MLP (multilayer perceptron and fuzzy KNN ( nearest neighbors. While the classification accuracy is similar, SART is shown to outperform the two other classifiers in terms of training speed and classification speed, especially for large databases. It is also easier to use since it does not require any input parameter related to its structure.

  7. Supervised Self-Organizing Classification of Superresolution ISAR Images: An Anechoic Chamber Experiment

    Science.gov (United States)

    Radoi, Emanuel; Quinquis, André; Totir, Felix

    2006-12-01

    The problem of the automatic classification of superresolution ISAR images is addressed in the paper. We describe an anechoic chamber experiment involving ten-scale-reduced aircraft models. The radar images of these targets are reconstructed using MUSIC-2D (multiple signal classification) method coupled with two additional processing steps: phase unwrapping and symmetry enhancement. A feature vector is then proposed including Fourier descriptors and moment invariants, which are calculated from the target shape and the scattering center distribution extracted from each reconstructed image. The classification is finally performed by a new self-organizing neural network called SART (supervised ART), which is compared to two standard classifiers, MLP (multilayer perceptron) and fuzzy KNN ([InlineEquation not available: see fulltext.] nearest neighbors). While the classification accuracy is similar, SART is shown to outperform the two other classifiers in terms of training speed and classification speed, especially for large databases. It is also easier to use since it does not require any input parameter related to its structure.

  8. Tracking of Range and Azimuth for Continuous Imaging of Marine Target in Monopulse ISAR with Wideband Echoes

    Directory of Open Access Journals (Sweden)

    Junhao Xie

    2016-01-01

    Full Text Available Real-time tracking of maneuvering targets is the prerequisite for continuous imaging of moving targets in inverse synthetic aperture radar (ISAR. In this paper, the range and azimuth tracking (RAT method with wideband radar echoes is first presented for a mechanical scanning monopulse ISAR, which is regarded as the simplest phased array unit due to the two antenna feeds. To relieve the estimation fluctuation and poor robustness of the RAT method with a single snapshot, a modified range and azimuth tracking approach based on centroid algorithm (RATCA with forgotten factor and multiple echoes is then proposed. The performances of different forgotten factors are investigated. Both theoretical analysis and experimental results demonstrate that RATCA is superior to RAT method. Particularly, when target echo is missing occasionally, RAT method fails while RATCA still keeps good performance. The potential of continuous imaging with shipborne ISAR is verified by experimental results. With minor modification, the method proposed in this paper can be potentially applied in the phased array radar.

  9. Synthetic range profiling, ISAR imaging of sea vessels and feature extraction, using a multimode radar to classify targets: initial results from field trials

    CSIR Research Space (South Africa)

    Abdul Gaffar, MY

    2011-04-01

    Full Text Available -based classification of small to medium sized sea vessels in littoral condition. The experimental multimode radar is based on an experimental tracking radar that was modified to generate SRP and ISAR images in both search and tracking modes. The architecture...

  10. 基于GPU的ISAR成像算法实现%The realization of ISAR imaging algorithm based on GPU

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    逆合成孔径雷达(inverse synthetic aperture radar,ISAR)是一种具有很高的成像分辨率的雷达,其成像过程是一项大数据量的高密度计算的处理任务。图形处理器(GPU)具有数十倍于CPU的浮点计算能力以及传输带宽,而CUDA 技术的发展使得多线程、单指令的 GPU 架构能够方便快速地进行并行计算。提出了一种在 cuda 平台上用GPU进行非相参成像处理的高效方法,利用GPU 的并行特性,实现了成像处理过程的并行化,与一般GPU 处理方法相比,其处理速度可以达到实时成像的效果,运算速率明显提高。%ISAR (Inverse Synthetic Aperture Radar inverse synthetic aperture radar)is a kind of high resolution imaging radar,the imaging process is a heavy task of processing the high density computing and a large amount of data. GPU has dozens of times the CPU floating-point computation capacity and transmission bandwidth.The development of CUDA technology makes the multi-threads,single instruction GPU architecture can quickly for parallel computing. This paper presents an efficient method of non coherent imaging using the parallel characteristic of GPU on the CUDA platform and realizes the parallel imaging processing.Compared with the general GPU processing method, the processing speed can achieve real-time imaging effect,and the operation rate is obviously improved.

  11. ISAR Motion Compensation using the Registration-Restoration-Fusion Method

    Science.gov (United States)

    2006-06-01

    diffusion de la cible et donne lieu A une image ISAR bien focalisre. Le concept de base consiste A utiliser la mrthode du voisin le plus proche pour...de restitution, pourrait etre utilis6e pour grnrrer [’image ISAR focalisre. Cette mrthode proposre a &6 appliqure avec succ~s A des donn~es ISAR tant...constitue une option efficace pour r~soudre la bavure de [’image caus~e par le comportement variable dans le temps et donne lieu At une image ISAR bien

  12. Micro-motion Recognition of Spatial Cone Target Based on ISAR Image Sequences

    Directory of Open Access Journals (Sweden)

    Changyong Shu

    2016-04-01

    Full Text Available The accurate micro-motions recognition of spatial cone target is the foundation of the characteristic parameter acquisition. For this reason, a micro-motion recognition method based on the distinguishing characteristics extracted from the Inverse Synthetic Aperture Radar (ISAR sequences is proposed in this paper. The projection trajectory formula of cone node strong scattering source and cone bottom slip-type strong scattering sources, which are located on the spatial cone target, are deduced under three micro-motion types including nutation, precession, and spinning, and the correctness is verified by the electromagnetic simulation. By comparison, differences are found among the projection of the scattering sources with different micro-motions, the coordinate information of the scattering sources in the Inverse Synthetic Aperture Radar sequences is extracted by the CLEAN algorithm, and the spinning is recognized by setting the threshold value of Doppler. The double observation points Interacting Multiple Model Kalman Filter is used to separate the scattering sources projection of the nutation target or precession target, and the cross point number of each scattering source’s projection track is used to classify the nutation or precession. Finally, the electromagnetic simulation data are used to verify the effectiveness of the micro-motion recognition method.

  13. Inverse synthetic aperture radar imaging principles, algorithms and applications

    CERN Document Server

    Chen , Victor C

    2014-01-01

    Inverse Synthetic Aperture Radar Imaging: Principles, Algorithms and Applications is based on the latest research on ISAR imaging of moving targets and non-cooperative target recognition (NCTR). With a focus on the advances and applications, this book will provide readers with a working knowledge on various algorithms of ISAR imaging of targets and implementation with MATLAB. These MATLAB algorithms will prove useful in order to visualize and manipulate some simulated ISAR images.

  14. 3D Geometry and Motion Estimations of Maneuvering Targets for Interferometric ISAR With Sparse Aperture.

    Science.gov (United States)

    Xu, Gang; Xing, Mengdao; Xia, Xiang-Gen; Zhang, Lei; Chen, Qianqian; Bao, Zheng

    2016-05-01

    In the current scenario of high-resolution inverse synthetic aperture radar (ISAR) imaging, the non-cooperative targets may have strong maneuverability, which tends to cause time-variant Doppler modulation and imaging plane in the echoed data. Furthermore, it is still a challenge to realize ISAR imaging of maneuvering targets from sparse aperture (SA) data. In this paper, we focus on the problem of 3D geometry and motion estimations of maneuvering targets for interferometric ISAR (InISAR) with SA. For a target of uniformly accelerated rotation, the rotational modulation in echo is formulated as chirp sensing code under a chirp-Fourier dictionary to represent the maneuverability. In particular, a joint multi-channel imaging approach is developed to incorporate the multi-channel data and treat the multi-channel ISAR image formation as a joint-sparsity constraint optimization. Then, a modified orthogonal matching pursuit (OMP) algorithm is employed to solve the optimization problem to produce high-resolution range-Doppler (RD) images and chirp parameter estimation. The 3D target geometry and the motion estimations are followed by using the acquired RD images and chirp parameters. Herein, a joint estimation approach of 3D geometry and rotation motion is presented to realize outlier removing and error reduction. In comparison with independent single-channel processing, the proposed joint multi-channel imaging approach performs better in 2D imaging, 3D imaging, and motion estimation. Finally, experiments using both simulated and measured data are performed to confirm the effectiveness of the proposed algorithm.

  15. Terahertz inverse synthetic aperture radar (ISAR) imaging with a quantum cascade laser transmitter.

    Science.gov (United States)

    Danylov, Andriy A; Goyette, Thomas M; Waldman, Jerry; Coulombe, Michael J; Gatesman, Andrew J; Giles, Robert H; Qian, Xifeng; Chandrayan, Neelima; Vangala, Shivashankar; Termkoa, Krongtip; Goodhue, William D; Nixon, William E

    2010-07-19

    A coherent transceiver using a THz quantum cascade (TQCL) laser as the transmitter and an optically pumped molecular laser as the local oscillator has been used, with a pair of Schottky diode mixers in the receiver and reference channels, to acquire high-resolution images of fully illuminated targets, including scale models and concealed objects. Phase stability of the received signal, sufficient to allow coherent image processing of the rotating target (in azimuth and elevation), was obtained by frequency-locking the TQCL to the free-running, highly stable optically pumped molecular laser. While the range to the target was limited by the available TQCL power (several hundred microwatts) and reasonably strong indoor atmospheric attenuation at 2.408 THz, the coherence length of the TQCL transmitter will allow coherent imaging over distances up to several hundred meters. Image data obtained with the system is presented.

  16. Bistatic SAR/ISAR/FSR geometry, signal models and imaging algorithms

    CERN Document Server

    Lazarov, Andon Dimitrov

    2013-01-01

    Bistatic radar consists of a radar system which comprises a transmitter and receiver which are separated by a distance comparable to the expected target distance. This book provides a general theoretical description of such bistatic technology in the context of synthetic aperture, inverse synthetic aperture and forward scattering radars from the point of view of analytical geometrical and signal formation as well as processing theory. Signal formation and image reconstruction algorithms are developed with the application of high informative linear frequency and phase code modulating techniques

  17. Three-Dimensional ISAR Imaging Method for High-Speed Targets in Short-Range Using Impulse Radar Based on SIMO Array

    Directory of Open Access Journals (Sweden)

    Xinpeng Zhou

    2016-03-01

    Full Text Available This paper proposes a three-dimensional inverse synthetic aperture radar (ISAR imaging method for high-speed targets in short-range using an impulse radar. According to the requirements for high-speed target measurement in short-range, this paper establishes the single-input multiple-output (SIMO antenna array, and further proposes a missile motion parameter estimation method based on impulse radar. By analyzing the motion geometry relationship of the warhead scattering center after translational compensation, this paper derives the receiving antenna position and the time delay after translational compensation, and thus overcomes the shortcomings of conventional translational compensation methods. By analyzing the motion characteristics of the missile, this paper estimates the missile’s rotation angle and the rotation matrix by establishing a new coordinate system. Simulation results validate the performance of the proposed algorithm.

  18. Three-Dimensional ISAR Imaging Method for High-Speed Targets in Short-Range Using Impulse Radar Based on SIMO Array.

    Science.gov (United States)

    Zhou, Xinpeng; Wei, Guohua; Wu, Siliang; Wang, Dawei

    2016-03-11

    This paper proposes a three-dimensional inverse synthetic aperture radar (ISAR) imaging method for high-speed targets in short-range using an impulse radar. According to the requirements for high-speed target measurement in short-range, this paper establishes the single-input multiple-output (SIMO) antenna array, and further proposes a missile motion parameter estimation method based on impulse radar. By analyzing the motion geometry relationship of the warhead scattering center after translational compensation, this paper derives the receiving antenna position and the time delay after translational compensation, and thus overcomes the shortcomings of conventional translational compensation methods. By analyzing the motion characteristics of the missile, this paper estimates the missile's rotation angle and the rotation matrix by establishing a new coordinate system. Simulation results validate the performance of the proposed algorithm.

  19. ISAR Imaging Method Based on the Bayesian Group-sparse Modeling%基于块稀疏贝叶斯模型的ISAR成像方法

    Institute of Scientific and Technical Information of China (English)

    吴称光; 邓彬; 苏伍各; 王宏强; 秦玉亮

    2015-01-01

    传统ISAR稀疏成像主要针对独立散射点散射系数的重构问题,然而实际情况下目标散射点之间并不是独立存在的,而是以区域或块的形式存在,在该情形下利用常用的稀疏重构算法并不能完全地刻画块状目标的真实结构,因此该文考虑采用块稀疏重构算法进行目标散射系数重建.基于块稀疏贝叶斯模型和变分推理的重构方法(VBGS),包含了稀疏贝叶斯学习(SBL)方法中参数学习的优点,其利用分层的先验分布来表征未知信号的稀疏块状信息,因而相对于现有的恢复算法能够更好地重建块稀疏信号.该方法基于变分贝叶斯推理原理,根据观测量能自动地估计信号未知参数,而无需人工参数设置.针对稀疏块状目标,该文结合压缩感知(CS)理论将VBGS方法用于ISAR成像,仿真实验成像结果表明该方法优于传统的成像结果,适合于具有块状结构的ISAR目标成像.%The traditional sparse ISAR imaging method mainly considers the recovery of coefficients on individual scatters. However, in the practice situation, the target scatters presented by blocks or groups do not emerge on individual. In this case, the usual sparse recover algorithm can not depict the shape of real target, thus, the group-sparse recover approaches are adopted to reconstruct the coefficients of target scatters. The recovery method based on the Bayesian Group-Sparse modeling and Variational inference (VBGS) uses a hierarchical construction of a general signal prior to model the group sparse signals and contain the merit of Sparse Bayesian Learning (SBL) on parameters learning, as a result, it can reconstruct the group sparse signal better than the usual recover algorithm. The VBGS method uses the variational Bayesian inference approach to estimate the parameters of the unknown signal automatically and does not require the parameter-tuning procedures. Considering the sparse group target, this paper combines the

  20. ISAR active jamming method based on sinusoidal modulation

    Institute of Scientific and Technical Information of China (English)

    Yu Zhang; Congfeng Liu; Yan Zhu

    2015-01-01

    It is potential y useful to perform deception or cover jamming using the rotating angular reflectors since they can form deception echoes along range and azimuth. Inspired by the cohe-rent jamming and micro-motion modulation, a novel active method is proposed for inverse synthetic aperture radar (ISAR). Radar pulses are sampled and frequency-modulated along azimuth by si-nusoidal signal, and then the jamming signals are retransmitted to the radar and the jamming images are induced after ISAR imaging. Therein, the jamming principle, key parameters and the jamming effect are discussed. The simulated data verify the effectiveness of the jamming method.

  1. 基于Gabor幅值特征和相位特征相融合的ISAR像目标识别%ISAR Image Recognition with Fusion of Gabor Magnitude and Phase Feature

    Institute of Scientific and Technical Information of China (English)

    王芳; 盛卫星; 马晓峰; 王昊

    2013-01-01

    A new Inverse Synthetic Aperture Radar (ISAR) target recognition method with the fusion of Gabor magnitude and phase feature is proposed. Firstly, the corresponding Gabor Magnitude Maps (GMMs) and Gabor phase information are obtained by convolving the ISAR image with multi-scale and multi-orientation Gabor filters. Secondly, each GMM is divided into several non-overlapping rectangular units, and the histogram of unit is computed and combined as the magnitude histogram feature. Thirdly, the local Gabor phase pattern is obtained by combining quadrant bit coding with local XOR pattern, and the block histogram feature is extracted from the local Gabor phase pattern. Then, the fusion of the Gabor magnitude and phase feature is used as the feature of ISAR image. Finally, five-type aircraft models are classified by using a nearest neighbor classifier with 2c as a dissimilarity measure in the computed feature space. The recognition method is tested on ISAR data simulated from Greco electromagnetic soft ware. Compared with other recognition methods, the numerical results show that the proposed method is effective and has higher recognition performance.%  该文提出一种基于 Gabor 小波变换幅值特征和相位特征相融合的 ISAR 像目标识别算法。首先将 ISAR像进行Gabor多尺度分析,对不同尺度、不同方向的Gabor幅值图像划分为若干矩形不重叠的子块,分别计算每个子块的直方图分布,将其联合起来作为Gabor的幅值特征;然后结合象限二进制编码和局部异或算子提取Gabor相位信息的局部相位模式,对得到的局部相位模式同样提取分块直方图特征;再把提取的幅值特征和相位特征相融合作为ISAR像最终的Gabor特征;最后在2c统计量作为不相似度量计算的特征空间里,采用最近邻分类器完成5类目标的分类识别。通过使用Greco电磁软件仿真的5类目标的ISAR数据对该方法进行目标识别的验证,并

  2. Logarithmic Laplacian Prior Based Bayesian Inverse Synthetic Aperture Radar Imaging.

    Science.gov (United States)

    Zhang, Shuanghui; Liu, Yongxiang; Li, Xiang; Bi, Guoan

    2016-04-28

    This paper presents a novel Inverse Synthetic Aperture Radar Imaging (ISAR) algorithm based on a new sparse prior, known as the logarithmic Laplacian prior. The newly proposed logarithmic Laplacian prior has a narrower main lobe with higher tail values than the Laplacian prior, which helps to achieve performance improvement on sparse representation. The logarithmic Laplacian prior is used for ISAR imaging within the Bayesian framework to achieve better focused radar image. In the proposed method of ISAR imaging, the phase errors are jointly estimated based on the minimum entropy criterion to accomplish autofocusing. The maximum a posterior (MAP) estimation and the maximum likelihood estimation (MLE) are utilized to estimate the model parameters to avoid manually tuning process. Additionally, the fast Fourier Transform (FFT) and Hadamard product are used to minimize the required computational efficiency. Experimental results based on both simulated and measured data validate that the proposed algorithm outperforms the traditional sparse ISAR imaging algorithms in terms of resolution improvement and noise suppression.

  3. Ultrasound focusing images in superlattices

    Energy Technology Data Exchange (ETDEWEB)

    Narita, Michiko; Tanaka, Yukihiro; Tamura, Shin-ichiro [Department of Applied Physics, Hokkaido University, Sapporo (Japan)

    2002-03-04

    We study theoretically ultrasound focusing in periodic multilayered structures, or superlattices, by solving the wave equation with the Green function method and calculating the transmitted ultrasound amplitude images of both the longitudinal and transverse modes. The constituent layers assumed are elastically isotropic but the periodically stacked structure is anisotropic. Thus anisotropy of ultrasound propagation is predicted even at low frequencies and it is enhanced significantly at higher frequencies due to the zone-folding effect of acoustic dispersion relations. An additional effect studied is the interference of ultrasound (known as the internal diffraction), which can be recognized when the propagation distance is comparable to the ultrasound wavelength. Numerical examples are developed for millimetre-scale Al/polymer multilayers used recently for imaging experiment with surface acoustic waves. (author)

  4. ISAR Imaging Algorithm Based on Focal Undetermined System Solver Method%基于欠定系统局灶解法的逆合成孔径雷达成像

    Institute of Scientific and Technical Information of China (English)

    江东; 童宁宁; 冯为可; 胡小伟

    2016-01-01

    In order to solve the problems of the existing signal reconstruction methods which have more or less defects such as big amount of calculation and needing the signal sparseness as the prior information,an improved method of ISAR imaging algorithm based on focal undetermined system solver was proposed.Of this method,conjugate gradient scheme based on QR decomposition was used to solve the linear equations in regularized focal undetermined system sol-ver (R-FOCUSS)method.Simulation results showed that it could obtain more clear imaging results and further im-proved the computing speed by using the improved method to reconstruct the received signal.%针对目前压缩感知中常用的信号重构算法普遍存在计算复杂、需要信号的稀疏度作为先验信息等缺陷的问题,提出了基于欠定系统局灶解法(Focal Undetermined System Solver,FOCUSS)的逆合成孔径雷达(Inversed Synthetic Aperture Radar,ISAR)成像方法。该方法利用 QR 分解预处理共轭梯度法求解正则化FOCUSS 算法中的线性方程组,在不需要先验信息的条件下进一步提高算法收敛速度。仿真实验表明,利用基于 QR 分解预处理共轭梯度法改进的正则化 FOCUSS 算法对回波信号进行重构,既能获得更加清晰的成像结果,又能进一步提高运算速度。

  5. Non-imaging, focusing heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.T.; Chong, K.K.; Bligh, T.P. [Univ. of Technology Malaysia, Faculty of Electrical Engineering, Johor (MY)] [and others

    2001-07-01

    A non-imaging focusing heliostat for effective use of thermal solar energy is proposed. The heliostat consists of a number of grouped slave mirrors, which are able to move according to a proposed formula to eliminate the first order aberration. The master tracks the sun by a proposed rotation-elevation mode to project solar rays together with the rest of slave mirrors into a fixed target. The merit of this design is that if may benefit the use of solar energy in high temperature applications by allowing a single stage collector to replace a conventional double stage structure; it may also benefit high concentration applications, e.g., solar powered Stirling engines, solar pumped lasers, etc. The feasibility and a reliability test of the proposed method by a prototype heliostat in the University of Technology, Malaysia is reported. (Author)

  6. Broadband circular interferometric millimetre-wave ISAR for threat detection

    Directory of Open Access Journals (Sweden)

    S. Bertl

    2007-06-01

    Full Text Available To detect threats on a person's body surface the application of millimetre-waves is possible. In order to get a view of the person from all sides either the person has to be rotated standing on a turntable (Inverse Synthetic Aperture Radar, ISAR or a sensor is moved on a circular path around the person (Synthetic Aperture Radar, SAR. The goal of the reconstruction is to obtain information about the shape of the threats and their positions in all three dimensions. At first the reconstruction is done along range and azimuth, which span the principal surface given by the sensor configuration. This paper reports on two methods to obtain the third spatial dimension. Due to the circular shape and its 3D focussing ability of the aperture this information can be obtained by the evaluation of the image focus. Secondly, if two coherent receiving channels are used, a possibility to achieve 3D spatial resolution is the processing of the interferometric phase. A comparison between these two will be presented.

  7. Inverse synthetic aperture radar imaging of targets with complex motion based on the local polynomial ambiguity function

    Science.gov (United States)

    Lv, Qian; Su, Tao; Zheng, Jibin

    2016-01-01

    In inverse synthetic aperture radar (ISAR) imaging of targets with complex motion, the azimuth echoes have to be modeled as multicomponent cubic phase signals (CPSs) after motion compensation. For the CPS model, the chirp rate and the quadratic chirp rate deteriorate the ISAR image quality due to the Doppler frequency shift; thus, an effective parameter estimation algorithm is required. This paper focuses on a parameter estimation algorithm for multicomponent CPSs based on the local polynomial ambiguity function (LPAF), which is simple and can be easily implemented via the complex multiplication and fast Fourier transform. Compared with the existing parameter estimation algorithm for CPS, the proposed algorithm can achieve a better compromise between performance and computational complexity. Then, the high-quality ISAR image can be obtained by the proposed LPAF-based ISAR imaging algorithm. The results of the simulated data demonstrate the effectiveness of the proposed algorithm.

  8. Simulation of two-dimensional ISAR decoys on a moving platform

    Institute of Scientific and Technical Information of China (English)

    Xiaoyi Pan; Wei Wang; Qixiang Fu; Dejun Feng; Guoyu Wang

    2015-01-01

    It is potential y useful to perform deception jamming using the digital image synthesizer (DIS) since it can form a two-dimensional (2D) decoy but suffers from multiple decoys ge-neration. Inspired by the intermittent sampling repeater jamming (ISRJ), the generation of inverse synthetic aperture radar (ISAR) decoys is addressed, associated with the DIS and the ISRJ. Radar pulses are sampled intermittently and modulated by the scatter-ing model of a false target by mounting the jammer on a moving platform, and then the jamming signals are retransmitted to the radar and a train of decoys are induced after ISAR imaging. A scattering model of Yak-42 is adopted as the false-target mo-dulation model to verify the effectiveness of the jamming method based on the standard ISAR motion compensation and image for-mation procedure.

  9. Resolution and Micro-Doppler Effect in Bi-ISAR System (in English

    Directory of Open Access Journals (Sweden)

    Deng Dong-hu

    2013-06-01

    Full Text Available Compared to the monostatic radar, bistatic radar has many special characteristics because of its spatial complexity. Bistatic Inverse Synthetic Aperture Radar (Bi-ISAR can be employed as a radar imaging tool for obtaining non-cooperative target images. In this study, we first analyze the range and azimuth resolution of a Bi-ISAR system. To analyze this azimuth resolution and its spatial-variety characteristic, a definition called con-Doppler bandwidth is introduced, which helps overcome the difficulty of the target’s viewing angle diversity calculation. Then, a detailed investigation is conducted to study the micro-Doppler effect caused by the vibration and the rotation of the target in the Bi-ISAR system. By comparing the difference in the micro-Doppler effect between the Bi-ISAR system and the Mono-ISAR system, we modify the extended Hough transform to extract the real micro-motion features of the targets. Finally, we provide some simulation results to validate the theoretical derivation and to illustrate the effectiveness of the proposed method.

  10. Focusing criterion in DHM image reconstruction

    Science.gov (United States)

    Mihailescu, M.; Mihale, N.; Popescu, R. C.; Acasandrei, A.; Paun, I. A.; Dinescu, M.; Scarlat, E.

    2015-02-01

    This study is presenting the theoretical approach and the practical results of a precise activity involved in the hologram reconstruction in order to find the optimally focused image of MG63 osteoblast-like cells cultivated on polymeric flat substrates. The morphology and dynamic of the cell is investigated by digital holographic microscopy (DHM) technique. The reconstruction is digitally performed using an algorithm based on the scalar theory of diffraction in the Fresnel approximation. The quality of the 3D images of the cells is crucially depending on the focusing capability of the reconstruction chain to fit the parameters of the optical recorder, particularly the focusing value. Our proposal to find the focused image is based on the images decomposition on gray levels and their histogram analysis. More precisely the focusing criterion is based on the evaluation of the form of this distribution.

  11. Deceptive Jamming Method with Micro-motion Property Against ISAR

    Directory of Open Access Journals (Sweden)

    N. Tai

    2017-09-01

    Full Text Available Airborne target's micro-motion such as rotation or vibration causes phase modulation, termed as micro-Doppler effect, into radar signals. The feature of micro-motion is one of the most obvious features for radar recognition in mid-course phase. In traditional works, it is assumed that the micro-motion of the scatterer is the same as the ballistic target. However, with the variation of the aspect angle of ISAR, the position of the scatterer changes. In this paper, the movement of a ballistic missile in mid-course is modeled and analyzed. A false target jamming method is proposed by combining the micro-motion modulation and the electromagnetic scattering modulation. Compared with the methods using ideal point models, our method is able to generate a vivid false target with structural information, micro-motion and variation of the scatterer's RCS. The micro-motion effect of the false target is presented through ISAR imaging and time-frequency analysis. The effectiveness and correctness of the algorithm is verified by simulation.

  12. Compressed Sensing ISAR Reconstruction Considering Highly Maneuvering Motion

    Directory of Open Access Journals (Sweden)

    Ahmed Shaharyar Khwaja

    2017-03-01

    Full Text Available In this report, we propose compressed sensing inverse synthetic aperture radar (ISAR imaging in the presence of highly maneuvering motion using a modified orthogonal matching pursuit (OMP reconstruction algorithm. Unlike existing methods where motion is limited to first- or second-order phase terms, we take into account realistic motion of a maneuvering target that can involve a third-order phase term corresponding to the rate of rotational acceleration. In addition, unlike existing fixed dictionary-based methods, which require designing a large dictionary that needs to take into account all of the possible motion parameters, we propose a modified OMP reconstruction method that requires a dictionary only based on the first-order phase term and estimates the secondand third-order phase terms using an optimization algorithm. Simulation examples and comparison with existing methods show the viability of our approach for imaging moving targets consisting of higher order motion.

  13. Spatial filters for focusing ultrasound images

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Gori, Paola

    2001-01-01

    . A new method for making spatial matched filter focusing of RF ultrasound data is proposed based on the spatial impulse response description of the imaging. The response from a scatterer at any given point in space relative to the transducer can be calculated, and this gives the spatial matched filter...

  14. 基于直方图统计量的逆合成孔径雷达目标识别%Target classification for ISAR image based on histogram statistics

    Institute of Scientific and Technical Information of China (English)

    王芳; 盛卫星; 马晓峰; 王昊

    2012-01-01

    将原用于人脸识别的基于Gabor局部二进制模式的识别技术用于逆合成孔径雷达(ISAR)像的雷达目标识别,对算法进行了改进,取得了较好的识别效果。将ISAR像进行Gabor小波变换,提取不同尺度和方向的Gabor幅值图谱;然后把幅值图谱分成小的子区域,用多尺度局部二值模式提取空域增强的直方图作为特征,最后在X2统计量作为不相似度量计算的特征空间里,采用最近邻分类器完成五类目标的分类识别。与目前已有的几种典型IsAR目标识别方法进行了对比,结果表明:该方法是可行且有效的,能够明显地提高识别率。%Local Gabor binary patterns (LGBP) method in face recognition is im- proved and applied in inverse synthetic aperture radar (ISAR) target recognition. Firstly, the corresponding Gabor magnitude maps (GMMs) are obtained by convol- ving the enhanced ISAR image with multi-scale and multi-orientation Gabor filters. Then, each GMM is divided into small regions from which multi-scale block local binary pattern is used to extract histogram features. At last, five-type aircraft mod- els are classified by using a nearest neighbor classifier with Chi square as a dissimi- larity measure in the computed feature space. Compared with other recognition methods, the numerical results show that the proposed method is effective and has higher recognition performance.

  15. Isar-Amperwerke AG: How we train quality consciousness, the willingness to provide services and team feeling; Isar Amperwerke AG: Wie wir Qualitaetsbewusstsein, Dienstleistungswillen und Wir-Gefuehl trainieren

    Energy Technology Data Exchange (ETDEWEB)

    Saupe, P.C. [Gesellschaft der Saupe und Partner Unternehmensgestaltung GmbH, Muenchen (Germany)

    1997-03-10

    Isar-Amperwerke prepare themselves for the electricity market becoming liberalised with a more intense competition. New image, increased communication with the market and customer-orientated conduct are the first measures. The training of management personnel and employees, in particular the people promoting quality, is an additional important module within the quality management system. (orig.) [Deutsch] Die Isar-Amperwerke bereiten sich auf den liberaler werdenden Strommarkt mit intensiverem Wettbewerb vor. Neues Erscheinungsbild, verstaerkte Marktkommunikation und kundenorientiertes Verhalten sind erste Massnahmen. Das Training von Fuehrungskraeften und Mitarbeitern, speziell der Qualitaetsfoerderer, ist ein weiterer wichtiger Baustein innerhalb des Qualitaetsmanagementsystems. (orig.)

  16. Comparison of Modelled to Measured High-Resolution ISAR Data

    NARCIS (Netherlands)

    Broek, A.C. van den; Bieker, T.; Ewijk, L.J. van

    2005-01-01

    We have obtained modelled ISAR data for a ZSU-23-4 air defence unit using a high-fidelity 600,000 facet model and the RAPPORT RCS prediction code. These ISAR data are compared with results from the FERMAT RCS prediction code using the same facet model of the ZSU23-4. In order to analyse how well the

  17. Use of Genetic Algorithms for Contrast and Entropy Optimization in ISAR Autofocusing

    Directory of Open Access Journals (Sweden)

    Martorella Marco

    2006-01-01

    Full Text Available Image contrast maximization and entropy minimization are two commonly used techniques for ISAR image autofocusing. When the signal phase history due to the target radial motion has to be approximated with high order polynomial models, classic optimization techniques fail when attempting to either maximize the image contrast or minimize the image entropy. In this paper a solution of this problem is proposed by using genetic algorithms. The performances of the new algorithms that make use of genetic algorithms overcome the problem with previous implementations based on deterministic approaches. Tests on real data of airplanes and ships confirm the insight.

  18. Logarithmic Laplacian Prior Based Bayesian Inverse Synthetic Aperture Radar Imaging

    Directory of Open Access Journals (Sweden)

    Shuanghui Zhang

    2016-04-01

    Full Text Available This paper presents a novel Inverse Synthetic Aperture Radar Imaging (ISAR algorithm based on a new sparse prior, known as the logarithmic Laplacian prior. The newly proposed logarithmic Laplacian prior has a narrower main lobe with higher tail values than the Laplacian prior, which helps to achieve performance improvement on sparse representation. The logarithmic Laplacian prior is used for ISAR imaging within the Bayesian framework to achieve better focused radar image. In the proposed method of ISAR imaging, the phase errors are jointly estimated based on the minimum entropy criterion to accomplish autofocusing. The maximum a posterior (MAP estimation and the maximum likelihood estimation (MLE are utilized to estimate the model parameters to avoid manually tuning process. Additionally, the fast Fourier Transform (FFT and Hadamard product are used to minimize the required computational efficiency. Experimental results based on both simulated and measured data validate that the proposed algorithm outperforms the traditional sparse ISAR imaging algorithms in terms of resolution improvement and noise suppression.

  19. FUSION OF MULTI FOCUSED IMAGES USING HDWT FOR MACHINE VISION

    Directory of Open Access Journals (Sweden)

    S. Arumuga Perumal

    2011-10-01

    Full Text Available During image acquisition in machine vision, due to limited depth of field of lens, it is possible to take clear image of the objects in the scene which are in focus only. The remaining objects in the scene will be out of focus. A possible solution to bring clear images of all objects in the scene is image fusion. Image fusion is a process of combining multiple images to form the composite image with extended information content. This paper uses three band expansive higher density discrete wavelet transform to fuse two numbers of images focusing different objects in the same scene and also proposes three methods for image fusion. Experimental results on multi focused image fusion are presented in terms of root mean square, peak signal to noise ratio and quality index to illustrate the proposed fusion methods.

  20. Performance limits for maritime Inverse Synthetic Aperture Radar (ISAR).

    Energy Technology Data Exchange (ETDEWEB)

    Doerry, Armin Walter

    2013-11-01

    The performance of an Inverse Synthetic Aperture Radar (ISAR) system depends on a variety of factors, many which are interdependent in some manner. In this report we specifically examine ISAR as applied to maritime targets (e.g. ships). It is often difficult to get your arms around the problem of ascertaining achievable performance limits, and yet those limits exist and are dictated by physics. This report identifies and explores those limits, and how they depend on hardware system parameters and environmental conditions. Ultimately, this leads to a characterization of parameters that offer optimum performance for the overall ISAR system. While the information herein is not new to the literature, its collection into a single report hopes to offer some value in reducing the seek time.

  1. The Problem of Focusing and Real Images

    Science.gov (United States)

    Mihas, Pavlos

    2008-01-01

    A historical discussion of the theories which deal with the formation of real images in mirrors and lenses is presented in this paper. Speculations on mirrors appeared as early as Plato. Euclid's, Hero's and Ptolemy's approaches to visual rays are described. The theory on burning mirrors starts with Diocles and later was continued by the Arabs. Al…

  2. Compensating focusing for space hyper spectral imager's fore optical system

    Institute of Scientific and Technical Information of China (English)

    Yicha Zhang; Wei Liu

    2011-01-01

    @@ The performance of space hyper spectral imager is severely affected by turbulent orbit temperature. Turbulence results in a defocus in the fore optical system of the imager. To address this problem, a focusing system is added. A number of simulation methods are applied on the fore optical system to study the relationship between temperature and focusing. In addition, this process is conducted to obtain a practical reference for focusing while the imager is flying on orbit. The obtained correlation between focusing and temperature is proven effective based on ground imaging and simulation testing.%The performance of space hyper spectral imager is severely affected by turbulent orbit temperature. Turbulence results in a defocus in the fore optical system of the imager. To address this problem, a focusing system is added. A number of simulation methods are applied on the fore optical system to study the relationship between temperature and focusing. In addition, this process is conducted to obtain a practical reference for focusing while the imager is flying on orbit. The obtained correlation between focusing and temperature is proven effective based on ground imaging and simulation testing.

  3. Weak Signals Extraction and Imaging Analysis in Bistatic ISAR Systems Based on Stochastic Resonance%基于随机共振理论的双基ISAR弱信号提取及成像分析

    Institute of Scientific and Technical Information of China (English)

    邓冬虎; 朱小鹏; 张群; 罗迎; 李宏伟

    2012-01-01

    在双基地逆合成孔径雷达成像系统中,针对强背景噪声中的目标弱散射点探测和识别问题,基于能捕获目标强散射点的假设前提,提出了应用随机共振理论的弱散射点检测方法.首先对作解线调后的回波信号进行快时间轴变换处理,并对处理后的信号进行二次采样使其满足绝热近似条件;然后应用随机共振技术检测出代表瞬时距离差的弱周期信号频率,并通过循环检测和正负频率判断等后续处理提高系统的检测信噪比以及确定弱散射点的正确位置.最后对随机共振性能和双基ISAR成像进行了仿真.结果表明:随机共振能大幅提高弱周期信号的输出信噪比,应用在双基ISAR系统中能有效提高系统的信噪比增益和扩大雷达接收机的动态范围.%In the bistatic ISAR systems, in order to solve the problems of weak scatters detection and identification in strong noise background,the stochastic resonance(SR) was applied to extract the information of weak scatters. On the assumption that the strong scatters could be detected, the signals after de-chirp were disposed through transformation in fast time axis firstly, which made the signals satisfy the condition of adiabatic approximation; then the SR was used to detect the signal frequency that expressed the instantaneous range difference; after that, some processing were implemented to confirm the right positions of weak scatters and to improve the output signal-noise-ratio(SNR) .Numerical simulations shows that the SR can improve the SNR largely and enlarge the dynamic bound of radar receiver.

  4. Study of residual aberration for non-imaging focusing heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.T.; Chong, K.K.; Lim, B.H.; Lim, C.S. [Institute of Energy and Environment, Malaysia University of Science and Technology, No. 17, Jalan SS7/26, Kelana Jaya, 47301 Petaling Jaya, Selangor (Malaysia)

    2003-08-01

    Instead of using a specific focusing geometry, a non-imaging focusing heliostat has no fixed geometry but is composed of many small movable element mirrors that can be manoeuvred to eliminate the first-order aberration. Following our previous publication on the principle of non-imaging focusing heliostat, this paper further explores higher order residual aberration that limits the size of the focusing spot. The residual aberration can be partially corrected by offsetting the pivot point of mirrors and pre-setting the tilting angles of mirrors.

  5. All in Focus Image Generation based on New Focusing Measure Operators

    Directory of Open Access Journals (Sweden)

    Hossam Eldeen M. Shamardan

    2016-12-01

    Full Text Available To generate an all in focus image, the Shape-From-Focus (SFF is used. The SFF key is finding the optimal focus depth at each pixel or area in an image within sequence of images. In this paper two new focusing measure operators are suggested to be used for SFF. The suggested operators are based on modification for the state of art tool for time-frequency analysis, the Stockwell Transform (ST. The first operator depends on Discrete Orthogonal Stockwell Transform (DOST which represents a pared version of ST, while the other depends on Pixelwise DOST (P-DOST which provides a local spatial frequency description. Both of the operators provides the computational complexity and memory demand efficiency compared to the operator depending on ST. A comparison between the suggested operators to operators based on ST are performed and showed that the suggested operators’ performances are as analogous to that of ST.

  6. Oblong-Shaped-Focused Transducers for Intravascular Ultrasound Imaging.

    Science.gov (United States)

    Lee, Junsu; Jang, Jihun; Chang, Jin Ho

    2017-03-01

    In intravascular ultrasound (IVUS) imaging, a transducer is inserted into a blood vessel and rotated to obtain image data. For this purpose, the transducer aperture is typically less than 0.5 mm in diameter, which causes natural focusing to occur in the imaging depth ranging from 1 to 5 mm. Due to the small aperture, however, it is not viable to conduct geometric focusing in order to enhance the spatial resolution of IVUS images. Furthermore, this hampers narrowing the slice thickness of a cross-sectional scan plane in the imaging depth, which leads to lowering spatial and contrast resolutions of IVUS images. To solve this problem, we propose an oblong-shaped-focused transducer for IVUS imaging. Unlike the conventional IVUS transducers with either a circular or a square flat aperture, the proposed transducer has an oblong aperture of which long side is positioned along a blood vessel. This unique configuration makes it possible to conduct geometric focusing at a desired depth in the elevation direction. In this study, furthermore, it is demonstrated that a spherically shaped aperture in both lateral and elevation directions also improves lateral resolution, compared to the conventional flat aperture. To ascertain this, the conventional and the proposed IVUS transducers were designed and fabricated to evaluate and to compare their imaging performances through wire phantom and tissue-mimicking phantom experiments. For the proposed 50-MHz IVUS transducer, a PZT piece of 0.5 × 1.0 mm(2) was spherically shaped for elevation focus at 3 mm by using the conventional press-focusing technique whereas the conventional one has a flat aperture of 0.5 × 0.5 mm(2). The experimental results demonstrated that the proposed IVUS transducer is capable of improving spatial and contrast resolutions of IVUS images.

  7. Analyzing the Focus Sensor Images for ODI at WIYN

    Science.gov (United States)

    Nowicki, Robert P.

    2006-12-01

    The WIYN (Wisconsin, Indiana, Yale, & NOAO) is building the One Degree Imager (ODI) for its 3.5m telescope at Kitt Peak. ODI is a wide field imager that is focusing on delivering the excellent image quality of the WIYN telescope. Maintaining good telescope focus is essential for the success of this instrument. A proposed technique for focusing ODI is using a CCD sensor that is tilted with respect to the instrument’s focal plane. We numerically analyzed images obtained with a prototype focus camera using several methods to determine the location of the best-focused stars. Specifically, a least chi-squares fit was used to fit a second order polynomial to the plot of FWHM versus pixel position along the CCD for the stars taken in these focus sensor images. Once ODI is operational at WIYN, one can use this algorithm to find the best FWHM and its position along the CCD, and feed this information back to the telescope control system. These numerical methods were implemented in the scripting language tcl/tk because of its easily built user interfaces and ready acceptance at Kitt Peak Observatory. R.P.N.'s research was supported by the NOAO/KPNO Research Experiences for Undergraduates (REU) Program which is funded by the National Science Foundation through Scientific Program Order No. 3 (AST-0243875) of the Cooperative Agreement No. AST-0132798 between the Association of Universities for Research in Astronomy (AURA) and the NSF.

  8. Image Quality Assessment for Performance Evaluation of Focus Measure Operators

    Directory of Open Access Journals (Sweden)

    Farida Memon

    2015-10-01

    Full Text Available This paper presents the performance evaluation of eight focus measure operators namely Image CURV (Curvature, GRAE (Gradient Energy, HISE (Histogram Entropy, LAPM (Modified Laplacian, LAPV (Variance of Laplacian, LAPD (Diagonal Laplacian, LAP3 (Laplacian in 3D Window and WAVS (Sum of Wavelet Coefficients. Statistical matrics such as MSE (Mean Squared Error, PNSR (Peak Signal to Noise Ratio, SC (Structural Content, NCC (Normalized Cross Correlation, MD (Maximum Difference and NAE (Normalized Absolute Error are used to evaluate stated focus measures in this research. . FR (Full Reference method of the image quality assessment is utilized in this paper. Results indicate that LAPD method is comparatively better than other seven focus operators at typical imaging conditions

  9. Atomic-focuser imaging in electron nanodiffraction from carbon nanoshells

    Science.gov (United States)

    Cowley

    2000-03-01

    When nanodiffraction patterns are obtained by transmission through the top and bottom walls of near-spherical, hollow carbon nano-shells, using the focused probe of a STEM instrument, a graphitic crystal in one wall may act as an atomic focuser to produce high-resolution images of small regions of the other wall within the central beam and the diffraction disks of the nanodiffraction pattern. A theoretical analysis of the imaging process is given. Images showing one- and two-dimensional periodicities, with fringe spacings as small as 0.124 nm, and also images showing non-periodic features have been obtained from carbon nanoshells having diameters of the order of 100 nm.

  10. Small Animal Radionuclide Imaging With Focusing Gamma-Ray Optics

    Energy Technology Data Exchange (ETDEWEB)

    Hill, R; Decker, T; Epstein, M; Ziock, K; Pivovaroff, M J; Craig, W W; Jernigan, J G; Barber, W B; Christensen, F E; Funk, T; Hailey, C J; Hasegawa, B H; Taylor, C

    2004-02-27

    Significant effort currently is being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. While physiological function in small animals can be localized and imaged using conventional radionuclide imaging techniques such as single-photon emission tomography (SPECT) and positron emission tomography (PET), these techniques inherently are limited to spatial resolutions of 1-2 mm. For this reason, we are developing a small animal radionuclide imaging system (SARIS) using grazing incidence optics to focus gamma-rays emitted by {sup 125}I and other radiopharmaceuticals. We have developed a prototype optic with sufficient accuracy and precision to focus the 27.5 keV photons from {sup 125}I onto a high-resolution imaging detector. Experimental measurements from the prototype have demonstrated that the optic can focus X-rays from a microfocus X-ray tube to a spot having physical dimensions (approximately 1500 microns half-power diameter) consistent with those predicted by theory. Our theoretical and numerical analysis also indicate that an optic can be designed and build that ultimately can achieve 100 {micro}m spatial resolution with sufficient efficiency to perform in vivo single photon emission imaging studies in small animal.

  11. Decontamination of the reactor pressure vessel and further internals and auxiliary systems in the German boiling water reactor Isar-1; Dekontamination des RDB inkl. der Einbauten wie Dampftrockner und Wasserabscheider sowie der angeschlossenen Hilfssysteme im deutschen Siedewasserreaktor ISAR 1

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Michael; Sempere Belda, Luis; Basu, Ashim; Topf, Christian [AREVA GmbH, Erlangen (Germany). Abt. Chemistry Services; Erbacher, Thomas; Hiermer, Thomas; Schnurr, Bernhard; Appeldorn, Thomas van [E.ON Kernkraft GmbH, Kernkraftwerk ISAR, Essenbach (Germany). Abt. Maschinentechnik; Volkmann, Christian [ESG Engineering Services GmbH, Greifswald (Germany)

    2015-12-15

    The German nuclear power plant ISAR 1 (KKI 1), a 878 MWe boiling water reactor of KWU design, was shut down on March 17{sup th}, 2011. With the objective to minimize the plants activity inventory accompanied by the reduction of contact dose rates of systems and components the project 'decontamination of the RPV incl. steam dryer and water separator and the connected auxiliary systems' was implemented in the first quarter of 2015. One major focus within the project was the specific in-situ decontamination of the steam dryer.

  12. Multi-Focus Image Fusion Based on NSCT and NSST

    Science.gov (United States)

    Moonon, Altan-Ulzii; Hu, Jianwen

    2015-12-01

    In this paper, a multi-focus image fusion algorithm based on the nonsubsampled contourlet transform (NSCT) and the nonsubsampled shearlet transform (NSST) is proposed. The source images are first decomposed by the NSCT and NSST into low frequency coefficients and high frequency coefficients. Then, the average method is used to fuse low frequency coefficient of the NSCT. To obtain more accurate salience measurement, the high frequency coefficients of the NSST and NSCT are combined to measure salience. The high frequency coefficients of the NSCT with larger salience are selected as fused high frequency coefficients. Finally, the fused image is reconstructed by the inverse NSCT. We adopt three metrics (Q AB/F , Q e and Q w ) to evaluate the quality of fused images. The experimental results demonstrate that the proposed method outperforms other methods. It retains highly detailed edges and contours.

  13. Microwave thermal imaging of scanned focused ultrasound heating: animal experiments

    Science.gov (United States)

    Zhou, Tian; Meaney, Paul M.; Hoopes, P. Jack; Geimer, Shireen D.; Paulsen, Keith D.

    2011-03-01

    High intensity focused ultrasound (HIFU) uses focused ultrasound beams to ablate localized tumors noninvasively. Multiple clinical trials using HIFU treatment of liver, kidney, breast, pancreas and brain tumors have been conducted, while monitoring the temperature distribution with various imaging modalities such as MRI, CT and ultrasound. HIFU has achieved only minimal acceptance partially due to insufficient guidance from the limited temperature monitoring capability and availability. MR proton resonance frequency (PRF) shift thermometry is currently the most effective monitoring method; however, it is insensitive in temperature changes in fat, susceptible to motion artifacts, and is high cost. Exploiting the relationship between dielectric properties (i.e. permittivity and conductivity) and tissue temperature, in vivo dielectric property distributions of tissue during heating were reconstructed with our microwave tomographic imaging technology. Previous phantom studies have demonstrated sub-Celsius temperature accuracy and sub-centimeter spatial resolution in microwave thermal imaging. In this paper, initial animal experiments have been conducted to further investigate its potential. In vivo conductivity changes inside the piglet's liver due to focused ultrasound heating were observed in the microwave images with good correlation between conductivity changes and temperature.

  14. Battle Damage Assessment Using Inverse Synthetic Aperture Radar (ISAR)

    Science.gov (United States)

    2004-12-01

    trihedral or multi-facet corner reflectors , or specular reflectors depending on the dynamic nature of the break-up process. It is difficult to...correspondence to the cross -range position of the target scattering points. Equation Section (Next) 8 B. ISAR SYSTEM ARCHITECTURE Figure 1 below... radar , ∆fD. Furthermore, since ∆fD = 1/ T, the cross -range resolution can be expressed as 2 2c D r f T λ λ ω ω ∆ = ∆ = (2.35) Radar LOS ωrc

  15. Nondestructive millimeter wave imaging and spectroscopy using dielectric focusing probes

    Energy Technology Data Exchange (ETDEWEB)

    Hejase, Jose A.; Shane, Steven S.; Park, Kyoung Y.; Chahal, Premjeet [Terahertz Systems Laboratory (TeSLa) - Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48823 (United States)

    2014-02-18

    A tool for interrogating objects over a wide band of frequencies with subwavelength resolution at small standoff distances (near field region) in the transmission mode using a single source and detector measurement setup in the millimeter wave band is presented. The design utilizes optics like principles for guiding electromagnetic millimeter waves from large cross-sectional areas to considerably smaller sub-wavelength areas. While plano-convex lenses can be used to focus waves to a fine resolution, they usually require a large stand-off distance thus resulting in alignment and spacing issues. The design procedure and simulation analysis of the focusing probes are presented in this study along with experimental verification of performance and imaging and spectroscopy examples. Nondestructive evaluation will find benefit from such an apparatus including biological tissue imaging, electronic package integrity testing, composite dielectric structure evaluation for defects and microfluidic sensing.

  16. Removing the twin image in digital holography by segmented filtering of in-focus twin image

    OpenAIRE

    2008-01-01

    We propose and investigate a new digital method for the reduction of twin-image noise from digital Fresnel holograms. For the case of in-line Fresnel holography the unwanted twin is present as a highly corruptive noise when the object image is numerically reconstructed. We propose to firstly reconstruct the unwanted twin-image when it is in-focus and in this plane we calculate a segmentation mask that borders this in focus image. The twin-image is then segmented and removed by sim...

  17. Analysis of Scanned Probe Images for Magnetic Focusing in Graphene

    Science.gov (United States)

    Bhandari, Sagar; Lee, Gil-Ho; Kim, Philip; Westervelt, Robert M.

    2017-02-01

    We have used cooled scanning probe microscopy (SPM) to study electron motion in nanoscale devices. The charged tip of the microscope was raster-scanned at constant height above the surface as the conductance of the device was measured. The image charge scatters electrons away, changing the path of electrons through the sample. Using this technique, we imaged cyclotron orbits that flow between two narrow contacts in the magnetic focusing regime for ballistic hBN-graphene-hBN devices. We present herein an analysis of our magnetic focusing imaging results based on the effects of the tip-created charge density dip on the motion of ballistic electrons. The density dip locally reduces the Fermi energy, creating a force that pushes electrons away from the tip. When the tip is above the cyclotron orbit, electrons are deflected away from the receiving contact, creating an image by reducing the transmission between contacts. The data and our analysis suggest that the graphene edge is rather rough, and electrons scattering off the edge bounce in random directions. However, when the tip is close to the edge, it can enhance transmission by bouncing electrons away from the edge, toward the receiving contact. Our results demonstrate that cooled SPM is a promising tool to investigate the motion of electrons in ballistic graphene devices.

  18. Extending RTM Imaging With a Focus on Head Waves

    Science.gov (United States)

    Holicki, Max; Drijkoningen, Guy

    2016-04-01

    Conventional industry seismic imaging predominantly focuses on pre-critical reflections, muting post-critical arrivals in the process. This standard approach neglects a lot of information present in the recorded wave field. This negligence has been partially remedied with the inclusion of head waves in more advanced imaging techniques, like Full Waveform Inversion (FWI). We would like to see post-critical information leave the realm of labour-intensive travel-time picking and tomographic inversion towards full migration to improve subsurface imaging and parameter estimation. We present a novel seismic imaging approach aimed at exploiting post-critical information, using the constant travel path for head-waves between shots. To this end, we propose to generalize conventional Reverse Time Migration (RTM) to scenarios where the sources for the forward and backward propagated wave-fields are not coinciding. RTM functions on the principle that backward propagated receiver data, due to a source at some locations, must overlap with the forward propagated source wave field, from the same source location, at subsurface scatterers. Where the wave-fields overlap in the subsurface there is a peak at the zero-lag cross-correlation, and this peak is used for the imaging. For the inclusion of head waves, we propose to relax the condition of coincident sources. This means that wave-fields, from non-coincident-sources, will not overlap properly in the subsurface anymore. We can make the wave-fields overlap in the subsurface again, by time shifting either the forward or backward propagated wave-fields until the wave-fields overlap. This is the same as imaging at non-zero cross-correlation lags, where the lag is the travel time difference between the two wave-fields for a given event. This allows us to steer which arrivals we would like to use for imaging. In the simplest case we could use Eikonal travel-times to generate our migration image, or we exclusively image the subsurface

  19. Image Analysis of Plasma Induced by Focused IR Pulsed Laser

    Directory of Open Access Journals (Sweden)

    Ahmad Hadi Ali

    2011-12-01

    Full Text Available Plasma induced by focused laser beam is very essential especially in laser material interaction. Preliminary study leading to this research has been carried out. A Q-switch Nd:YAG laser was employed as a source of energy. The laser was focused using a wide-angle camera lens. The formation of plasma at the focal region was visualized perpendicularly using a CCD video camera interfaced to an image processing system. The dynamic expansion of the laser plasma was grabbed in conjunction with a high-speed photographic system. The observation results show that the plasma was formed in an ellipsoidal shape. The lateral width and the length of the plasma were found gradually increased

  20. Computer-assisted detection of epileptiform focuses on SPECT images

    Science.gov (United States)

    Grzegorczyk, Dawid; Dunin-Wąsowicz, Dorota; Mulawka, Jan J.

    2010-09-01

    Epilepsy is a common nervous system disease often related to consciousness disturbances and muscular spasm which affects about 1% of the human population. Despite major technological advances done in medicine in the last years there was no sufficient progress towards overcoming it. Application of advanced statistical methods and computer image analysis offers the hope for accurate detection and later removal of an epileptiform focuses which are the cause of some types of epilepsy. The aim of this work was to create a computer system that would help to find and diagnose disorders of blood circulation in the brain This may be helpful for the diagnosis of the epileptic seizures onset in the brain.

  1. Multi-focus image fusion using a guided-filter-based difference image.

    Science.gov (United States)

    Yan, Xiang; Qin, Hanlin; Li, Jia; Zhou, Huixin; Yang, Tingwu

    2016-03-20

    The aim of multi-focus image fusion technology is to integrate different partially focused images into one all-focused image. To realize this goal, a new multi-focus image fusion method based on a guided filter is proposed and an efficient salient feature extraction method is presented in this paper. Furthermore, feature extraction is primarily the main objective of the present work. Based on salient feature extraction, the guided filter is first used to acquire the smoothing image containing the most sharpness regions. To obtain the initial fusion map, we compose a mixed focus measure by combining the variance of image intensities and the energy of the image gradient together. Then, the initial fusion map is further processed by a morphological filter to obtain a good reprocessed fusion map. Lastly, the final fusion map is determined via the reprocessed fusion map and is optimized by a guided filter. Experimental results demonstrate that the proposed method does markedly improve the fusion performance compared to previous fusion methods and can be competitive with or even outperform state-of-the-art fusion methods in terms of both subjective visual effects and objective quality metrics.

  2. Imaging Nanophotonic Modes of Microresonators using a Focused Ion Beam

    CERN Document Server

    Twedt, Kevin A; Davanco, Marcelo; Srinivasan, Kartik; McClelland, Jabez J; Aksyuk, Vladimir A

    2016-01-01

    Optical microresonators have proven powerful in a wide range of applications, including cavity quantum electrodynamics, biosensing, microfludics, and cavity optomechanics. Their performance depends critically on the exact distribution of optical energy, confined and shaped by the nanoscale device geometry. Near-field optical probes can image this distribution, but the physical probe necessarily perturbs the near field, which is particularly problematic for sensitive high quality factor resonances. We present a new approach to mapping nanophotonic modes that uses a controllably small and local optomechanical perturbation introduced by a focused lithium ion beam. An ion beam (radius about 50 nm) induces a picometer-scale dynamic deformation of the resonator surface, which we detect through a shift in the optical resonance wavelength. We map five modes of a silicon microdisk resonator (Q > 20,000) with both high spatial and spectral resolution. Our technique also enables in-situ observation of ion implantation d...

  3. Localized Harmonic Motion Imaging for Focused Ultrasound Surgery Targeting

    Science.gov (United States)

    Curiel, Laura; Hynynen, Kullervo

    2011-01-01

    Recently, an in vivo real-time ultrasound-based monitoring technique that uses localized harmonic motion (LHM) to detect changes in tissues during focused ultrasound surgery (FUS) has been proposed to control the exposure. This technique can potentially be used as well for targeting imaging. In the present study we evaluated the potential of using LHM to detect changes in stiffness and the feasibility of using it for imaging purposes in phantoms and in vivo tumor detection. A single-element FUS transducer (80 mm focal length, 100 mm diameter, 1.485 MHz) was used for inducing a localized harmonic motion and a separate ultrasound diagnostic transducer excited by a pulser/receiver (5 kHz PRF, 5 MHz) was used to track motion. The motion was estimated using cross-correlation techniques on the acquired RF signal. Silicon phantom studies were performed in order to determine the size of inclusion that was possible to detect using this technique. Inclusions were discerned from the surroundings as a reduction on LHM amplitude and it was possible to depict inclusions as small as 4 mm. The amplitude of the induced LHM was always lower at the inclusions as compared with the one obtained at the surroundings. Ten New Zealand rabbits had VX2 tumors implanted on their thighs and LHM was induced and measured at the tumor region. Tumors (as small as 10 mm in length and 4 mm in width) were discerned from the surroundings as a reduction on LHM amplitude. PMID:21683514

  4. Joint Multi-Focus Fusion and Bayer ImageRestoration

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    In this paper, a joint multifocus image fusion and Bayer pattern image restoration algorithm for raw images of single-sensor colorimaging devices is proposed. Different from traditional fusion schemes, the raw Bayer pattern images are fused before colorrestoration. Therefore, the Bayer image restoration operation is only performed one time. Thus, the proposed algorithm is moreefficient than traditional fusion schemes. In detail, a clarity measurement of Bayer pattern image is defined for raw Bayer patternimages, and the fusion operator is performed on superpixels which provide powerful grouping cues of local image feature. Theraw images are merged with refined weight map to get the fused Bayer pattern image, which is restored by the demosaicingalgorithm to get the full resolution color image. Experimental results demonstrate that the proposed algorithm can obtain betterfused results with more natural appearance and fewer artifacts than the traditional algorithms.

  5. Multi-focus image fusion based on spatial frequency and morphological operators

    Institute of Scientific and Technical Information of China (English)

    Bin Yang; Shutao Li

    2007-01-01

    A new multi-focus image fusion method using spatial frequency (SF) and morphological operators is proposed. Firstly, the focus regions are detected using SF criteria. Then the morphological operators are used to smooth the regions. Finally the fused image is constructed by cutting and pasting the focused regions of the source images. Experimental results show that the proposed algorithm performs well for multi-focus image fusion.

  6. Assessment of image quality in x-ray radiography imaging using a small plasma focus device

    Science.gov (United States)

    Kanani, A.; Shirani, B.; Jabbari, I.; Mokhtari, J.

    2014-08-01

    This paper offers a comprehensive investigation of image quality parameters for a small plasma focus as a pulsed hard x-ray source for radiography applications. A set of images were captured from some metal objects and electronic circuits using a low energy plasma focus at different voltages of capacitor bank and different pressures of argon gas. The x-ray source focal spot of this device was obtained to be about 0.6 mm using the penumbra imaging method. The image quality was studied by several parameters such as image contrast, line spread function (LSF) and modulation transfer function (MTF). Results showed that the contrast changes by variations in gas pressure. The best contrast was obtained at a pressure of 0.5 mbar and 3.75 kJ stored energy. The results of x-ray dose from the device showed that about 0.6 mGy is sufficient to obtain acceptable images on the film. The measurements of LSF and MTF parameters were carried out by means of a thin stainless steel wire 0.8 mm in diameter and the cut-off frequency was obtained to be about 1.5 cycles/mm.

  7. In-focus quantitative intensity and phase imaging with the numerical focusing transport of intensity equation method

    Science.gov (United States)

    Tian, Xiaolin; Meng, Xin; Yu, Wei; Song, Xiaojun; Xue, Liang; Liu, Cheng; Wang, Shouyu

    2016-10-01

    Microscopy combined with the transport of intensity equation is capable of retrieving both intensity and phase distributions of samples from both in-focus and defocus intensities. However, during measurements, the focal plane is often decided artificially and the improper choice may induce errors in quantitative intensity and phase retrieval. In order to obtain accurate in-focus information, quantitative intensity and phase imaging with the numerical focusing transport of intensity equation method combined with cellular duty ratio criterion and numerical wavefront propagation is introduced in this paper. Both numerical simulations and experimental measurements are provided proving this designed method can increase both retrieved in-focus intensity and phase accuracy and reduce dependence of focal plane determination in transport of intensity equation measurements. It is believed that the proposed method can be potentially applied in various fields as in-focus compensation for quantitative phase imaging and automatic focal plane determination, etc.

  8. Locomotion of microspheres for imaging and light focusing applications

    CERN Document Server

    Krivitsky, Leonid A; Wang, Zengbo; Lukiyanchuk, Boris

    2013-01-01

    Super-resolution imaging using sub-diffraction field localization by micron sized transparent beads (microspheres) was recently demonstrated [1]. Practical applications in microscopy require control over the positioning of the microspheres. We present a simple method of positioning and controllable movement of a microsphere by using a glass micropipette. This allows sub-diffraction imaging at arbitrary points in three dimensions, as well as the ability to track moving objects. The results are relevant to a broad scope of applications, including sample inspection, and bio-imaging.

  9. Nanosecond gating properties of proximity focused microchannel plate image intensifiers

    Science.gov (United States)

    King, N. S. P.; King, N. S. P.; Yates, G. J.; Jaramillo, S. A.; Noel, B. W.; Detch, J. L., Jr.; Ogle, J. W.

    The optical gating properties of Multichannel plate image intensifiers were characterized. Emphasis was placed on parameters relevant to gating speed and correlations between the applied electrical and resultant optical gates.

  10. Image registration of interferometric inverse synthetic aperture radar imaging system based on joint respective window sampling and modified motion compensation

    Science.gov (United States)

    Tian, Biao; Shi, Si; Liu, Yang; Xu, Shiyou; Chen, Zengping

    2015-01-01

    We propose a new image registration method based on joint respective window sampling (RWS) and modified motion compensation (MMC) in an interferometric inverse synthetic aperture radar (InISAR) imaging system using two antennas. The causation and quantitative analysis of the offset between two ISAR images of different antennas along the baseline are analyzed. In the proposed method, the RWS method, according to the measured distance between the target and different antennas, compensates the offset in the range direction. The MMC method is adopted to eliminate the offset in the Doppler direction. Simulation results demonstrate that the offset between the two ISAR images can be compensated effectively, consequently achieving a high-quality three-dimensional InISAR image.

  11. An electrically tunable imaging system with separable focus and zoom functions using composite liquid crystal lenses.

    Science.gov (United States)

    Chen, Ming-Syuan; Chen, Po-Ju; Chen, Michael; Lin, Yi-Hsin

    2014-05-19

    We demonstrated an electrically tunable optical image system with separable focus function and zoom function based on three tunable focusing composite liquid crystal (LC) lenses. One LC lens in charge of the focus function helps to maintain the formed image at the same position and the other two LC lenses in charge of zoom function assist to continuously form an image at image sensor with tunable magnification of image size. The detail optical mechanism is investigated and the concept is demonstrated experimentally. The magnifications of the images can be switched continuously for the target in a range between 10 cm and 100 cm. The optical zoom ratio of this system maintains a constant~6.5:1 independent of the object distance. This study provides not only a guideline to design the image system with an electrically optical zoom, but also provide an experimental process to show how to operate the tunable focusing lenses in such an image system.

  12. Elastodynamic Marchenko focusing, green's function retrieval and imaging

    NARCIS (Netherlands)

    Wapenaar, C.P.A.; Slob, E.C.

    2015-01-01

    Building on acoustic autofocusing in 1D media, we previously proposed acoustic Marchenko imaging for 1D and 3D media. Recently, the first steps have been set towards extending the single-sided Marchenko method to the elastodynamic situation. Here we discuss the extension of single-sided Marchenko fo

  13. Enhancement of out-of-focus images using fusion-based PSF estimation and restoration

    Science.gov (United States)

    Yoon, Joonshik; Shin, Jeong-Ho; Paik, Joon-Ki

    2000-12-01

    In this paper, we propose an enhancement algorithm of out-of- focused images using fusion-based Point-spread-function (PSF) estimation and restoration. The proposed algorithm can make in-focused image by using only digital image processing techniques, and it requires neither infrared light/ultrasound nor focusing lens assembly operated by electrically powered movement of focusing lens. In order to increase accuracy in estimating the PSF of the defocus image, the proposed algorithm finds true and linear edges by using Canny edge detector, which is optimal edge detector and has good localization, estimates the step response across the edge for each pixel, computes the one-dimensional step response by averaging the step responses, estimates the two-dimensional PSF from the averaged step response, and then provides in- focused image by image restoration filter based on the estimated PSF. Finally, we execute fusion process, which can enhance the quality of the fused image by fusing restored images. There is a limit of the amount of out-of-focus, which can be recovered by the proposed algorithm. Moreover, the proposed algorithm is operating under assumption that an input image contains at least one piece-wise linear boundary between an object and background. In spite of above-mentioned limitations, the proposed algorithm can make acceptable quality of focused image by using only digital image processing.

  14. Auto-focus technology and its application based on image processing

    OpenAIRE

    YANG Tao; Zuo, Yong; Chen, Xiaomei

    2009-01-01

    Auto-focusing technique is an important method to improve the precision,intelligentization,automatization for the indentation diameter measurement.The paper introduces an auto-focus method of indentation diameter measurement based on image processing.Hard core of the auto-focusing technique is the evaluation function's selection.Based on the auto-focusing algorithms investigation,image sharpness evaluation functions are built based on vector model and DCT.Using experiments,it is found that th...

  15. Development and validation of the Spanish Interval Scale of Anxiety Response (ISAR).

    Science.gov (United States)

    Heaton, Lisa J; Garcia, Laura J; Gledhill, Lance W; Beesley, Kent A; Coldwell, Susan E

    2007-01-01

    As increasing attention is paid to disparities in oral health care, cross-cultural means for assessing dental fear, a significant barrier to dental care, are in high demand. There is, however, a surprising shortage of Spanish-language dental fear measures in the literature, despite evidence of dental fear and avoidance in Spanish-speaking populations. The goals of the current series of studies were to develop and validate a Spanish-language version of the Interval Scale of Anxiety Response (ISAR). Magnitude estimation, a technique in which participants are asked to assign a number to indicate the perceived intensity of a stimulus or phrase, was used to compare the Spanish ISAR to the original English ISAR during the development studies. As a result of the 4 initial development studies, modifications were made to both the Spanish and English scales. Once 2 seemingly equivalent scales were established, validation studies were completed with native Spanish- and English-speaking dental patients. The results suggest that both the Spanish and modified English ISAR scales are valid measures of state anxiety associated with dental treatment. Additionally, the results of these studies highlight the importance of thoroughly testing translated measures to ensure they are accurately assessing that which they purport to measure.

  16. Time-resolved quantitative multiphase interferometric imaging of a highly focused ultrasound pulse

    CERN Document Server

    Souris, Fabien; Jacquier, Philippe; Dupont-Roc, Jacques; Arvengas, Arnaud; Caupin, Frédéric; 10.1364/AO.49.006127

    2010-01-01

    Interferometric imaging is a well established method to image phase objects by mixing the image wavefront with a reference one on a CCD camera. It has also been applied to fast transient phenomena, mostly through the analysis of single interferograms. It is shown that for repetitive phenomena multiphase acquisition brings significant advantages. A 1 MHz focused sound field emitted by a hemispherical piezotransducer in water is imaged as an example. Quantitative image analysis provides high resolution sound field profiles. Pressure at focus determined by this method agrees with measurements from a fiber-optic probe hydrophone. This confirms that multiphase interferometric imaging can indeed provide quantitative measurements.

  17. The Primary Study of Microscopical Focus Problem in the Color Image of Pigmented Spots

    Institute of Scientific and Technical Information of China (English)

    WANG Li; JIANG Da-lin

    2006-01-01

    Pigmented spot is an important branch in the science of skin. But when processing those images, the microscopical focusing problem arises. It affects the image recognition later. In order to find the best method to solve it, comparison and analysis are given to various existing methods of image fusion in this paper.The conclusion is wavelet transform based on pixel -level.

  18. Implementation of total focusing method for phased array ultrasonic imaging on FPGA

    Science.gov (United States)

    Guo, JianQiang; Li, Xi; Gao, Xiaorong; Wang, Zeyong; Zhao, Quanke

    2015-02-01

    This paper describes a multi-FPGA imaging system dedicated for the real-time imaging using the Total Focusing Method (TFM) and Full Matrix Capture (FMC). The system was entirely described using Verilog HDL language and implemented on Altera Stratix IV GX FPGA development board. The whole algorithm process is to: establish a coordinate system of image and divide it into grids; calculate the complete acoustic distance of array element between transmitting array element and receiving array element, and transform it into index value; then index the sound pressure values from ROM and superimpose sound pressure values to get pixel value of one focus point; and calculate the pixel values of all focus points to get the final imaging. The imaging result shows that this algorithm has high SNR of defect imaging. And FPGA with parallel processing capability can provide high speed performance, so this system can provide the imaging interface, with complete function and good performance.

  19. Multi-focus Image Fusion Using Epifluorescence Microscopy for Robust Vascular Segmentation

    Science.gov (United States)

    Pelapur, Rengarajan; Prasath, V. B. Surya; Bunyak, Filiz; Glinskii, Olga V.; Glinsky, Vladislav V.; Huxley, Virginia H.; Palaniappan, Kannappan

    2015-01-01

    Automatic segmentation of three-dimensional microvascular structures is needed for quantifying morphological changes to blood vessels during development, disease and treatment processes. Single focus two-dimensional epifluorescent imagery lead to unsatisfactory segmentations due to multiple out of focus vessel regions that have blurred edge structures and lack of detail. Additional segmentation challenges include varying contrast levels due to diffusivity of the lectin stain, leakage out of vessels and fine morphological vessel structure. We propose an approach for vessel segmentation that combines multi-focus image fusion with robust adaptive filtering. The robust adaptive filtering scheme handles noise without destroying small structures, while multi-focus image fusion considerably improves segmentation quality by deblurring out-of-focus regions through incorporating 3D structure information from multiple focus steps. Experiments using epifluorescence images of mice dura mater show an average of 30.4% improvement compared to single focus microvasculature segmentation. PMID:25571050

  20. Image-based control of the magnetic resonance imaging-guided focused ultrasound thermotherapy.

    Science.gov (United States)

    Salomir, Rares; Delemazure, Anne-Sophie; Palussière, Jean; Rouvière, Olivier; Cotton, François; Chapelon, Jean-Yves

    2006-06-01

    Magnetic resonance imaging (MRI)-guided focused ultrasound surgery (FUS) is a full noninvasive approach for localized thermal ablation of deep tissues, coupling the following: (1) a versatile, nonionizing physical agent for therapy and (2) a state-of-the art diagnosis and on-line monitoring tool. A commercially available, Food and Drug Administration-approved device using the MRI-guided FUS exists since 2004 for the ablation of benign tumors (uterine fibroids); however, the ultimate goal of the technological, methodological, and medical research in this field is to provide a clinical-routine tool for fighting localized cancer. When addressing cancer applications, the accurate spatial control of the delivered thermal dose is mandatory. Contiguous destruction of the target volume must be achieved in a minimum time, whereas sparing as much as possible the neighboring healthy tissues and especially when some adjacent regions are critical. This paper reviews some significant developments reported in the literature related to the image-based control of the FUS therapy for kidney, breast, prostate, and brain, including the own experience of the authors on the active feedback control of the temperature during FUS ablation. In addition, preliminary results of an original study of MRI-guided FUS ablation of VX2 carcinoma in kidney, under active temperature control, are described here.

  1. Human skin image analysis using coherent focused beam scattering

    Science.gov (United States)

    Zimnyakov, Dmitry A.; Tuchin, Valery V.; Utz, Sergei R.; Mishin, Alexey A.

    1995-02-01

    The analysis of statistical and correlation properties of speckle patterns formed during different skin tissue scanning by the sharply focused probing laser beam has been carried out. The influences of the biotissues' structural features on the speckle patterns formation under Gaussian beam illumination have been investigated. The relationships between the structural characteristics of the sample under study, Rayleigh range of the probing beam and normalized statistical moments of the speckle intensity (contrast and asymmetry coefficient) are discussed for the different scatterer models. A phenomenological model of speckle pattern formation for the large-scale scatterers allows us to explain the dependence of speckle contrast and the coefficient of asymmetry on the generalized structure parameters and illumination conditions for the samples under study. The experimental investigations of the human skin structure features have been carried out using two types of the tissue samples by means of coherent scanning microscopy (CSM). Firstly, D-SQUAME discs (CuDerm Corporation, Texas, USA) have been used for the evaluation of skin dryness level. Secondly, the samples under study were the thin layers of normal and psoriatic epidermis (skin strippings). The dependencies of contrast and coefficient of asymmetry on the beam defocusing parameter and 2D correlation functions of speckle pattern intensity have been analyzed for different zones on the biotissue's surface. Particularly, promising results in skin dryness studies (using D-SQUAME discs) have been obtained. Our results and conventional 5-pattern kit scale are in good agreement. So, the presented method is accurate and objective and may be useful in novel cosmetic research and development.

  2. Researches on the measurement of distribution image of radiated noise using focused beamforming

    Institute of Scientific and Technical Information of China (English)

    HUI Juan; HU Dan; HUI Junying; YIN Jingwei

    2008-01-01

    A method using focused beamforming to measure the distribution image (under-water image) of submarine and surface ship's noise sources is presented. Level linear array can measure the target image on water level, but the multi-path interference of underwater acoustic channel may affect the quality of it. Virtual time reversal mirror and virtual array can both solve the problem very well; they make the image with high resolution.

  3. Imaging the anterior eye with dynamic-focus swept-source optical coherence tomography

    Science.gov (United States)

    Su, Johnny P.; Li, Yan; Tang, Maolong; Liu, Liang; Pechauer, Alex D.; Huang, David; Liu, Gangjun

    2015-12-01

    A custom-built dynamic-focus swept-source optical coherence tomography (SS-OCT) system with a central wavelength of 1310 nm was used to image the anterior eye from the cornea to the lens. An electrically tunable lens was utilized to dynamically control the positions of focusing planes over the imaging range of 10 mm. The B-scan images were acquired consecutively at the same position but with different focus settings. The B-scan images were then registered and averaged after filtering the out-of-focus regions using a Gaussian window. By fusing images obtained at different depth focus locations, high-resolution and high signal-strength images were obtained over the entire imaging depth. In vivo imaging of human anterior segment was demonstrated. The performance of the system was compared with two commercial OCT systems. The human eye ciliary body was better visualized with the dynamic-focusing SS-OCT system than using the commercial 840 and 1310 nm OCT systems. The sulcus-to-sulcus distance was measured, and the result agreed with that acquired with ultrasound biomicroscopy.

  4. Image Plane Phase Difference Auto Focus%像面相位差AF

    Institute of Scientific and Technical Information of China (English)

    张礅

    2014-01-01

    像面相位差AF是一种新型对焦技术,通过将图像传感器的一部分像素用像面相位差AF像素群加以置换,实现相位差检测,并用于对焦,具有对焦速度快、易于小型化的特点,具有很好的应用前景。%Image plane phase difference auto focus is a new auto focus technology. Part of pixels in image sensor is displaced by image plane phase difference auto focus pixels groups to detect phase difference and auto focus. Because of its better speed in auto foucusing and easily being miniaturization, the technology of Image plane phase difference auto focus has bright future in application.

  5. Multi-focus image fusion and robust encryption algorithm based on compressive sensing

    Science.gov (United States)

    Xiao, Di; Wang, Lan; Xiang, Tao; Wang, Yong

    2017-06-01

    Multi-focus image fusion schemes have been studied in recent years. However, little work has been done in multi-focus image transmission security. This paper proposes a scheme that can reduce data transmission volume and resist various attacks. First, multi-focus image fusion based on wavelet decomposition can generate complete scene images and optimize the perception of the human eye. The fused images are sparsely represented with DCT and sampled with structurally random matrix (SRM), which reduces the data volume and realizes the initial encryption. Then the obtained measurements are further encrypted to resist noise and crop attack through combining permutation and diffusion stages. At the receiver, the cipher images can be jointly decrypted and reconstructed. Simulation results demonstrate the security and robustness of the proposed scheme.

  6. Optimal multi-focus contourlet-based image fusion algorithm selection

    Science.gov (United States)

    Lutz, Adam; Giansiracusa, Michael; Messer, Neal; Ezekiel, Soundararajan; Blasch, Erik; Alford, Mark

    2016-05-01

    Multi-focus image fusion is becoming increasingly prevalent, as there is a strong initiative to maximize visual information in a single image by fusing the salient data from multiple images for visualization. This allows an analyst to make decisions based on a larger amount of information in a more efficient manner because multiple images need not be cross-referenced. The contourlet transform has proven to be an effective multi-resolution transform for both denoising and image fusion through its ability to pick up the directional and anisotropic properties while being designed to decompose the discrete two-dimensional domain. Many studies have been done to develop and validate algorithms for wavelet image fusion, but the contourlet has not been as thoroughly studied. When the contourlet coefficients for the wavelet coefficients are substituted in image fusion algorithms, it is contourlet image fusion. There are a multitude of methods for fusing these coefficients together and the results demonstrate that there is an opportunity for fusing coefficients together in the contourlet domain for multi-focus images. This paper compared the algorithms with a variety of no reference image fusion metrics including information theory based, image feature based and structural similarity based assessments to select the image fusion method.

  7. Ultrasonic imaging in coarse-grained stainless steels by total focusing method

    Science.gov (United States)

    Villaverde, E. Lopez; Robert, S.; Prada, C.

    2016-02-01

    In the present work, the Total Focusing Method (TFM) is used to image flaws in coarse-grained steels with a contact phased-array probe. In order to reduce the noise introduced by the heterogeneous structure, as well as artifacts due to surface guided waves, the Decomposition of the Time Reversal Operator method is performed before calculating TFM images.

  8. High-intensity focused ultrasound monitoring using harmonic motion imaging for focused ultrasound (HMIFU) under boiling or slow denaturation conditions.

    Science.gov (United States)

    Hou, Gary Y; Marquet, Fabrice; Wang, Shutao; Apostolakis, Iason-Zacharias; Konofagou, Elisa E

    2015-07-01

    Harmonic motion imaging for focused ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method that utilizes an amplitude-modulated therapeutic ultrasound beam to induce an oscillatory radiation force at the HIFU focus and estimates the focal tissue displacement to monitor the HIFU thermal treatment. In this study, the performance of HMIFU under acoustic, thermal, and mechanical effects was investigated. The performance of HMIFU was assessed in ex vivo canine liver specimens (n = 13) under slow denaturation or boiling regimes. A passive cavitation detector (PCD) was used to assess the acoustic cavitation activity, and a bare-wire thermocouple was used to monitor the focal temperature change. During lesioning with slow denaturation, high quality displacements (correlation coefficient above 0.97) were observed under minimum cavitation noise, indicating the tissue initial-softening-then- stiffening property change. During HIFU with boiling, HMIFU monitored a consistent change in lesion-to-background displacement contrast (0.46 ± 0.37) despite the presence of strong cavitation noise due to boiling during lesion formation. Therefore, HMIFU effectively monitored softening-then-stiffening during lesioning under slow denaturation, and detected lesioning under boiling with a distinct change in displacement contrast under boiling in the presence of cavitation. In conclusion, HMIFU was shown under both boiling and slow denaturation regimes to be effective in HIFU monitoring and lesioning identification without being significantly affected by cavitation noise.

  9. High Intensity Focused Ultrasound Monitoring using Harmonic Motion Imaging for Focused Ultrasound (HMIFU) under boiling or slow denaturation conditions

    Science.gov (United States)

    Hou, Gary Y.; Marquet, Fabrice; Wang, Shutao; Apostolakis, Iason-Zacharias; Konofagou, Elisa E.

    2015-01-01

    Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a recently developed High-Intensity Focused Ultrasound (HIFU) treatment monitoring method that utilizes an amplitude-modulated therapeutic ultrasound beam to induce an oscillatory radiation force at the HIFU focus and estimates the focal tissue displacement to monitor the HIFU thermal treatment. In this study, the performance of HMIFU under acoustic, thermal and mechanical effects were investigated. The performance of HMIFU was assessed in ex vivo canine liver specimens (n=13) under slow denaturation or boiling regimes. Passive Cavitation Detector (PCD) was used to assess the acoustic cavitation activity while a bare-wire thermocouple was used to monitor the focal temperature change. During lesioning with slow denaturation, high quality displacements (correlation coefficient above 0.97) were observed under minimum cavitation noise, indicating tissue the initial-softening-then-stiffening property change. During HIFU with boiling, HMIFU monitored a consistent change in lesion-to-background displacement contrast (0.46±0.37) despite the presence of strong cavitation noise due to boiling during lesion formation. Therefore, HMIFU effectively monitored softening-then-stiffening during lesioning under slow denaturation, and detected lesioning under boiling with a distinct change in displacement contrast under boiling in the presence of cavitation. In conclusion, HMIFU was shown effective in HIFU monitoring and lesioning identification without being significantly affected by cavitation noise. PMID:26168177

  10. Synthetic Aperture Focusing Applied to Imaging Using a Rotating Single Element Transducer

    DEFF Research Database (Denmark)

    Kortbek, Jacob; Jensen, Jørgen Arendt; Gammelmark, Kim Løkke

    2007-01-01

    This paper applies the concept of virtual sources and mono-static synthetic aperture focusing (SAF) to 2-dimensional imaging with a single rotating mechanically focused concave element with the objective of improving lateral resolution and signal-to-noise ratio (SNR). The geometrical focal point ...

  11. An image based auto-focusing algorithm for digital fundus photography.

    Science.gov (United States)

    Moscaritolo, Michele; Jampel, Henry; Knezevich, Frederick; Zeimer, Ran

    2009-11-01

    In fundus photography, the task of fine focusing the image is demanding and lack of focus is quite often the cause of suboptimal photographs. The introduction of digital cameras has provided an opportunity to automate the task of focusing. We have developed a software algorithm capable of identifying best focus. The auto-focus (AF) method is based on an algorithm we developed to assess the sharpness of an image. The AF algorithm was tested in the prototype of a semi-automated nonmydriatic fundus camera designed to screen in the primary care environment for major eye diseases. A series of images was acquired in volunteers while focusing the camera on the fundus. The image with the best focus was determined by the AF algorithm and compared to the assessment of two masked readers. A set of fundus images was obtained in 26 eyes of 20 normal subjects and 42 eyes of 28 glaucoma patients. The 95% limits of agreement between the readers and the AF algorithm were -2.56 to 2.93 and -3.7 to 3.84 diopter and the bias was 0.09 and 0.71 diopter, for the two readers respectively. On average, the readers agreed with the AF algorithm on the best correction within less than 3/4 diopter. The intraobserver repeatability was 0.94 and 1.87 diopter, for the two readers respectively, indicating that the limit of agreement with the AF algorithm was determined predominantly by the repeatability of each reader. An auto-focus algorithm for digital fundus photography can identify the best focus reliably and objectively. It may improve the quality of fundus images by easing the task of the photographer.

  12. Auto-focused panoramic dental tomosynthesis imaging with exponential polynomial based sharpness indicators

    Science.gov (United States)

    Lee, Taewon; Lee, Yeon Ju; Cho, Seungryong

    2017-02-01

    In this paper, we develop an improved auto-focusing capability of a panoramic dental tomosynthesis imager. We propose an auto-focusing algorithm with an efficient sharpness indicator based on exponential polynomials which provides better quantitation of steep gradients than the conventional one based on algebraic polynomials. With its accurate estimation of the sharpness of the reconstructed slices, the proposed method resulted in a better performance of automatically extracting in-focus slices in the dental panoramic tomosynthesis.

  13. Evaluate thermal lesion using Nakagami imaging for monitoring of high-intensity focused ultrasound

    Science.gov (United States)

    Zhang, Siyuan; Li, Chong; Zhou, Fanyu; Wang, Supin; Wan, Mingxi

    2017-03-01

    High-intensity focused ultrasound (HIFU) is currently being developed as a noninvasive technique for the treatment of cancer located in various tissues. Cavitation microbubbles (MBs) have been potential to aid treatment while the acoustic posterior shadowing effects of MBs influence the accuracy for defining the location and range of ablated thermal lesions during focused ultrasound surgery when using ultrasonic monitoring imaging. This work explored the feasibility of using ultrasonic Nakagami imaging to evaluate the ablated region induced by focused ultrasound exposures at different acoustic power levels in transparent tissue-mimicking phantoms.

  14. Nakagami imaging for detecting thermal lesions induced by high-intensity focused ultrasound in tissue.

    Science.gov (United States)

    Rangraz, Parisa; Behnam, Hamid; Tavakkoli, Jahan

    2014-01-01

    High-intensity focused ultrasound induces focalized tissue coagulation by increasing the tissue temperature in a tight focal region. Several methods have been proposed to monitor high-intensity focused ultrasound-induced thermal lesions. Currently, ultrasound imaging techniques that are clinically used for monitoring high-intensity focused ultrasound treatment are standard pulse-echo B-mode ultrasound imaging, ultrasound temperature estimation, and elastography-based methods. On the contrary, the efficacy of two-dimensional Nakagami parametric imaging based on the distribution of the ultrasound backscattered signals to quantify properties of soft tissue has recently been evaluated. In this study, ultrasound radio frequency echo signals from ex vivo tissue samples were acquired before and after high-intensity focused ultrasound exposures and then their Nakagami parameter and scaling parameter of Nakagami distribution were estimated. These parameters were used to detect high-intensity focused ultrasound-induced thermal lesions. Also, the effects of changing the acoustic power of the high-intensity focused ultrasound transducer on the Nakagami parameters were studied. The results obtained suggest that the Nakagami distribution's scaling and Nakagami parameters can effectively be used to detect high-intensity focused ultrasound-induced thermal lesions in tissue ex vivo. These parameters can also be used to understand the degree of change in tissue caused by high-intensity focused ultrasound exposures, which could be interpreted as a measure of degree of variability in scatterer concentration in various parts of the high-intensity focused ultrasound lesion.

  15. Digital focusing of OCT images based on scalar diffraction theory and information entropy

    Science.gov (United States)

    Liu, Guozhong; Zhi, Zhongwei; Wang, Ruikang K.

    2012-01-01

    This paper describes a digital method that is capable of automatically focusing optical coherence tomography (OCT) en face images without prior knowledge of the point spread function of the imaging system. The method utilizes a scalar diffraction model to simulate wave propagation from out-of-focus scatter to the focal plane, from which the propagation distance between the out-of-focus plane and the focal plane is determined automatically via an image-definition-evaluation criterion based on information entropy theory. By use of the proposed approach, we demonstrate that the lateral resolution close to that at the focal plane can be recovered from the imaging planes outside the depth of field region with minimal loss of resolution. Fresh onion tissues and mouse fat tissues are used in the experiments to show the performance of the proposed method. PMID:23162717

  16. Optimizing MR imaging-guided navigation for focused ultrasound interventions in the brain

    Science.gov (United States)

    Werner, B.; Martin, E.; Bauer, R.; O'Gorman, R.

    2017-03-01

    MR imaging during transcranial MR imaging-guided Focused Ultrasound surgery (tcMRIgFUS) is challenging due to the complex ultrasound transducer setup and the water bolus used for acoustic coupling. Achievable image quality in the tcMRIgFUS setup using the standard body coil is significantly inferior to current neuroradiologic standards. As a consequence, MR image guidance for precise navigation in functional neurosurgical interventions using tcMRIgFUS is basically limited to the acquisition of MR coordinates of salient landmarks such as the anterior and posterior commissure for aligning a stereotactic atlas. Here, we show how improved MR image quality provided by a custom built MR coil and optimized MR imaging sequences can support imaging-guided navigation for functional tcMRIgFUS neurosurgery by visualizing anatomical landmarks that can be integrated into the navigation process to accommodate for patient specific anatomy.

  17. Adaptive ultrasonic imaging with the total focusing method for inspection of complex components immersed in water

    Science.gov (United States)

    Le Jeune, L.; Robert, S.; Dumas, P.; Membre, A.; Prada, C.

    2015-03-01

    In this paper, we propose an ultrasonic adaptive imaging method based on the phased-array technology and the synthetic focusing algorithm Total Focusing Method (TFM). The general principle is to image the surface by applying the TFM algorithm in a semi-infinite water medium. Then, the reconstructed surface is taken into account to make a second TFM image inside the component. In the surface reconstruction step, the TFM algorithm has been optimized to decrease computation time and to limit noise in water. In the second step, the ultrasonic paths through the reconstructed surface are calculated by the Fermat's principle and an iterative algorithm, and the classical TFM is applied to obtain an image inside the component. This paper presents several results of TFM imaging in components of different geometries, and a result obtained with a new technology of probes equipped with a flexible wedge filled with water (manufactured by Imasonic).

  18. Photoacoustic-guided focused ultrasound (PAFUSion for identifying reflection artifacts in photoacoustic imaging

    Directory of Open Access Journals (Sweden)

    Mithun Kuniyil Ajith Singh

    2015-12-01

    Full Text Available Influence of acoustic inhomogeneities and resulting reflection artifacts is an important problem in reflection-mode photoacoustic imaging. Absorption of light by skin and superficial optical absorbers will generate photoacoustic transients, which traverse into the tissue and get reflected from structures having different acoustic impedance. These reflected photoacoustic signals, when reconstructed, may appear in the region of interest, which causes difficulties in image interpretation. We propose a novel method to identify and potentially eliminate reflection artifacts in photoacoustic images using photoacoustic-guided focused ultrasound [PAFUSion]. Our method uses focused ultrasound pulses to mimic the wave field produced by photoacoustic sources and thus provides a way to identify reflection artifacts in clinical combined photoacoustic and pulse-echo ultrasound. Simulation and phantom results are presented to demonstrate the validity and impact of this method. Results show that PAFUSion can identify reflections in photoacoustic images and thus envisages potential for improving photoacoustic imaging of acoustically inhomogeneous tissue.

  19. Impact of multi-focused images on recognition of soft biometric traits

    Science.gov (United States)

    Chiesa, V.; Dugelay, J. L.

    2016-09-01

    In video surveillance semantic traits estimation as gender and age has always been debated topic because of the uncontrolled environment: while light or pose variations have been largely studied, defocused images are still rarely investigated. Recently the emergence of new technologies, as plenoptic cameras, yields to deal with these problems analyzing multi-focus images. Thanks to a microlens array arranged between the sensor and the main lens, light field cameras are able to record not only the RGB values but also the information related to the direction of light rays: the additional data make possible rendering the image with different focal plane after the acquisition. For our experiments, we use the GUC Light Field Face Database that includes pictures from the First Generation Lytro camera. Taking advantage of light field images, we explore the influence of defocusing on gender recognition and age estimation problems. Evaluations are computed on up-to-date and competitive technologies based on deep learning algorithms. After studying the relationship between focus and gender recognition and focus and age estimation, we compare the results obtained by images defocused by Lytro software with images blurred by more standard filters in order to explore the difference between defocusing and blurring effects. In addition we investigate the impact of deblurring on defocused images with the goal to better understand the different impacts of defocusing and standard blurring on gender and age estimation.

  20. Symmetrical optical imaging system with bionic variable-focus lens for off-axis aberration correction

    Science.gov (United States)

    Wang, Xuan-Yin; Du, Jia-Wei; Zhu, Shi-Qiang

    2017-09-01

    A bionic variable-focus lens with symmetrical layered structure was designed to mimic the crystalline lens. An optical imaging system based on this lens and with a symmetrical structure that mimics the human eye structure was proposed. The refractive index of the bionic variable-focus lens increases from outside to inside. The two PDMS lenses with a certain thickness were designed to improve the optical performance of the optical imaging system and minimise the gravity effect of liquid. The paper presents the overall structure of the optical imaging system and the detailed description of the bionic variable-focus lens. By pumping liquid in or out of the cavity, the surface curvatures of the rear PDMS lens were varied, resulting in a change in the focal length. The focal length range of the optical imaging system was 20.71-24.87 mm. The optical performance of the optical imaging system was evaluated by imaging experiments and analysed by ray tracing simulations. On the basis of test and simulation results, the optical performance of the system was quite satisfactory. Off-axis aberrations were well corrected, and the image quality was greatly improved.

  1. Three dimensional imaging of gold-nanoparticles tagged samples using phase retrieval with two focus planes.

    Science.gov (United States)

    Ilovitsh, Tali; Ilovitsh, Asaf; Weiss, Aryeh; Meir, Rinat; Zalevsky, Zeev

    2015-10-26

    Optical sectioning microscopy can provide highly detailed three dimensional (3D) images of biological samples. However, it requires acquisition of many images per volume, and is therefore time consuming, and may not be suitable for live cell 3D imaging. We propose the use of the modified Gerchberg-Saxton phase retrieval algorithm to enable full 3D imaging of gold-particle tagged samples using only two images. The reconstructed field is free space propagated to all other focus planes using post processing, and the 2D z-stack is merged to create a 3D image of the sample with high fidelity. Because we propose to apply the phase retrieving on nano particles, the regular ambiguities typical to the Gerchberg-Saxton algorithm, are eliminated. The proposed concept is presented and validated both on simulated data as well as experimentally.

  2. Exogenous Molecular Probes for Targeted Imaging in Cancer: Focus on Multi-modal Imaging

    Directory of Open Access Journals (Sweden)

    Bishnu P. Joshi

    2010-06-01

    Full Text Available Cancer is one of the major causes of mortality and morbidity in our healthcare system. Molecular imaging is an emerging methodology for the early detection of cancer, guidance of therapy, and monitoring of response. The development of new instruments and exogenous molecular probes that can be labeled for multi-modality imaging is critical to this process. Today, molecular imaging is at a crossroad, and new targeted imaging agents are expected to broadly expand our ability to detect and manage cancer. This integrated imaging strategy will permit clinicians to not only localize lesions within the body but also to manage their therapy by visualizing the expression and activity of specific molecules. This information is expected to have a major impact on drug development and understanding of basic cancer biology. At this time, a number of molecular probes have been developed by conjugating various labels to affinity ligands for targeting in different imaging modalities. This review will describe the current status of exogenous molecular probes for optical, scintigraphic, MRI and ultrasound imaging platforms. Furthermore, we will also shed light on how these techniques can be used synergistically in multi-modal platforms and how these techniques are being employed in current research.

  3. Metamaterial fibres for subdiffraction imaging and focusing at terahertz frequencies over optically long distances

    Science.gov (United States)

    Tuniz, Alessandro; Kaltenecker, Korbinian J.; Fischer, Bernd M.; Walther, Markus; Fleming, Simon C.; Argyros, Alexander; Kuhlmey, Boris T.

    2013-10-01

    Using conventional materials, the resolution of focusing and imaging devices is limited by diffraction to about half the wavelength of light, as high spatial frequencies do not propagate in isotropic materials. Wire array metamaterials, because of their extreme anisotropy, can beat this limit; however, focusing with these has only been demonstrated up to microwave frequencies and using propagation over a few wavelengths only. Here we show that the principle can be scaled to frequencies orders of magnitudes higher and to considerably longer propagation lengths. We demonstrate imaging through straight and tapered wire arrays operating in the terahertz spectrum, with unprecedented propagation of near field information over hundreds of wavelengths and focusing down to 1/28 of the wavelength with a net increase in power density. Applications could include in vivo terahertz-endoscopes with resolution compatible with imaging individual cells.

  4. Optical analysis for simplified astigmatic correction of non-imaging focusing heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Chong, K.K. [Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Off Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur (Malaysia)

    2010-08-15

    In the previous work, non-imaging focusing heliostat that consists of m x n facet mirrors can carry out continuous astigmatic correction during sun-tracking with the use of only (m + n - 2) controllers. For this paper, a simplified astigmatic correction of non-imaging focusing heliostat is proposed for reducing the number of controllers from (m + n - 2) to only two. Furthermore, a detailed optical analysis of the new proposal has been carried out and the simulated result has shown that the two-controller system can perform comparably well in astigmatic correction with a much simpler and more cost effective design. (author)

  5. Synthetically Focused Imaging Techniques in Simulated Austenitic Steel Welds Using AN Ultrasonic Phased Array

    Science.gov (United States)

    Connolly, G. D.; Lowe, M. J. S.; Rokhlin, S. I.; Temple, J. A. G.

    2010-02-01

    In austenitic steel welds employed in safety-critical applications, detection of defects that may propagate during service or may have occurred during welding is particularly important. In this study, synthetically focused imaging techniques are applied to the echoes received by phased arrays in order to reconstruct images of the interior of a simulated austenitic steel weld, with application to sizing and location of simplified defects. Using a ray-tracing approach through a previously developed weld model, we briefly describe and then apply three focusing techniques. Results generated via both ray-tracing theory and finite element simulations will be shown.

  6. Deep focus; a digital image processing technique to produce improved focal depth in light microscopy:

    OpenAIRE

    Goldsmith, Noel T.

    2000-01-01

    In light microscopy, the spatial transverse resolution is a function of the wavelength and numerical aperture. The depth resolution is another function of these parameters. The factors that enable the detection of fine detail, make the sharp focusing of more than a thin slice of the depth in an object impossible. When the examination of fracture surfaces is attempted using light reflection microscopy, the roughness will often restrict the in-focus parts of an image to a small portion of the f...

  7. Multi-focus Image Fusion Algorithms%多聚焦图像融合算法

    Institute of Scientific and Technical Information of China (English)

    张攀

    2012-01-01

    Multi-focus image fusion is to combine information from two or multiple images of the same scene but different focus points for producing a merged image, which makes fused images more clear. The representative algorithms of multi-focus image fusion are swarm intelligence algorithm fusion methods, which achieve good effect, such as genetic algorithm (GA), particle swarm optimization (PSO) and so on. Currently, the optimization of swarm intelligence algorithms to improve and accelerate the integration of image speed is a major research direction.%多聚焦图像融合,是将两幅(或多幅)对同一场景的各个目标,聚焦不同的图像融合成一幅清晰的新图像.在多聚焦图像融合中,典型的群智能算法图像融合方法取得了较好的效果,如遗传算法、粒子群算法等.目前,对群智能算法的优化改进,加快图像的融合速度是一个主要的研究方向.

  8. Imaging with depth extension: where are the limits in fixed- focus cameras?

    Science.gov (United States)

    Bakin, Dmitry; Keelan, Brian

    2008-08-01

    The integration of novel optics designs, miniature CMOS sensors, and powerful digital processing into a single imaging module package is driving progress in handset camera systems in terms of performance, size (thinness) and cost. The miniature cameras incorporating high resolution sensors and fixed-focus Extended Depth of Field (EDOF) optics allow close-range reading of printed material (barcode patterns, business cards), while providing high quality imaging in more traditional applications. These cameras incorporate modified optics and digital processing to recover the soft-focus images and restore sharpness over a wide range of object distances. The effects a variety of parameters of the imaging module on the EDOF range were analyzed for a family of high resolution CMOS modules. The parameters include various optical properties of the imaging lens, and the characteristics of the sensor. The extension factors for the EDOF imaging module were defined in terms of an improved absolute resolution in object space while maintaining focus at infinity. This definition was applied for the purpose of identifying the minimally resolvable object details in mobile cameras with bar-code reading feature.

  9. Ultrasonic array imaging in nondestructive evaluation: total focusing method with using circular coherence factor

    Science.gov (United States)

    Zhang, Jie; Drinkwater, Bruce W.; Wilcox, Paul D.

    2013-01-01

    Ultrasonic array imaging algorithms have been widely used and developed in non-destructive evaluation in the last 10 years. In this paper, a widely-used imaging algorithms, Total Focusing Method (TFM), was further developed with using the phase statistical information of the scattering field from a scatterer, i.e., Circular Coherence Factor (CCF). TFM and TFM with using CCF are compared through both simulation and experimental measurements. In the simulation, array data sets were generated by using a hybrid forward model containing a single defect amongst a multitude of randomly distributed point scatterers to represent backscatter from material microstructure. The number of point scatterers per unit area and their scattering amplitude were optimized to reduce computation cost. The Signal to Noise Ratio (SNR) of the finial images and their resolution were used to indicate the quality of the different imaging algorithms. The images of different types of defect (point reflectors and planar cracks) were used to investigate the robustness of the imaging algorithms. It is shown that, with using CCF, higher image resolution can be achieved, but that the images of cracks are distorted. It is also shown that the detection limit of the imaging algorithms is almost equal for weakly scattering defects.

  10. The power of Kawaii: viewing cute images promotes a careful behavior and narrows attentional focus.

    Directory of Open Access Journals (Sweden)

    Hiroshi Nittono

    Full Text Available Kawaii (a Japanese word meaning "cute" things are popular because they produce positive feelings. However, their effect on behavior remains unclear. In this study, three experiments were conducted to examine the effects of viewing cute images on subsequent task performance. In the first experiment, university students performed a fine motor dexterity task before and after viewing images of baby or adult animals. Performance indexed by the number of successful trials increased after viewing cute images (puppies and kittens; M ± SE=43.9 ± 10.3% improvement more than after viewing images that were less cute (dogs and cats; 11.9 ± 5.5% improvement. In the second experiment, this finding was replicated by using a non-motor visual search task. Performance improved more after viewing cute images (15.7 ± 2.2% improvement than after viewing less cute images (1.4 ± 2.1% improvement. Viewing images of pleasant foods was ineffective in improving performance (1.2 ± 2.1%. In the third experiment, participants performed a global-local letter task after viewing images of baby animals, adult animals, and neutral objects. In general, global features were processed faster than local features. However, this global precedence effect was reduced after viewing cute images. Results show that participants performed tasks requiring focused attention more carefully after viewing cute images. This is interpreted as the result of a narrowed attentional focus induced by the cuteness-triggered positive emotion that is associated with approach motivation and the tendency toward systematic processing. For future applications, cute objects may be used as an emotion elicitor to induce careful behavioral tendencies in specific situations, such as driving and office work.

  11. The power of Kawaii: viewing cute images promotes a careful behavior and narrows attentional focus.

    Science.gov (United States)

    Nittono, Hiroshi; Fukushima, Michiko; Yano, Akihiro; Moriya, Hiroki

    2012-01-01

    Kawaii (a Japanese word meaning "cute") things are popular because they produce positive feelings. However, their effect on behavior remains unclear. In this study, three experiments were conducted to examine the effects of viewing cute images on subsequent task performance. In the first experiment, university students performed a fine motor dexterity task before and after viewing images of baby or adult animals. Performance indexed by the number of successful trials increased after viewing cute images (puppies and kittens; M ± SE=43.9 ± 10.3% improvement) more than after viewing images that were less cute (dogs and cats; 11.9 ± 5.5% improvement). In the second experiment, this finding was replicated by using a non-motor visual search task. Performance improved more after viewing cute images (15.7 ± 2.2% improvement) than after viewing less cute images (1.4 ± 2.1% improvement). Viewing images of pleasant foods was ineffective in improving performance (1.2 ± 2.1%). In the third experiment, participants performed a global-local letter task after viewing images of baby animals, adult animals, and neutral objects. In general, global features were processed faster than local features. However, this global precedence effect was reduced after viewing cute images. Results show that participants performed tasks requiring focused attention more carefully after viewing cute images. This is interpreted as the result of a narrowed attentional focus induced by the cuteness-triggered positive emotion that is associated with approach motivation and the tendency toward systematic processing. For future applications, cute objects may be used as an emotion elicitor to induce careful behavioral tendencies in specific situations, such as driving and office work.

  12. Towards Inverse Synthetic Aperture Radar (ISAR) for small sea vessels

    CSIR Research Space (South Africa)

    Abdul Gaffar, MY

    2006-12-01

    Full Text Available ( ) ( ) ( ) 2 0 1 24 2 ', ' R vt at j c j px qx r S t e h x y e dxdy pi pi   + +  −    − −  = ∫∫ Range alignment Uncompensated Range profiles Autofocus techniques Compensated Range profiles Uncompensated Doppler FFT... processing Compensated Doppler JTF processing Single image over processing interval Several images over processing interval Target Range Range Dwell time Dwell time JFT can be used to deal effectively with non-uniform rotation...

  13. The International Space Analogue Rock Store (ISAR): A key tool for future planetary exploration.

    Science.gov (United States)

    Bost, N.; Westall, F.; Ramboz, C.; Foucher, F.

    2012-04-01

    In order to prepare the next in situ space missions we have created a « lithothèque » of analogue rocks for calibrating and testing future (and existing) space flight instruments. This rock collection is called the International Space Analogue Rockstore (ISAR) and is hosted in the CNRS and the Observatoire des Sciences de l'Univers en Region Centre (OSUC) in Orléans. For maximum science return, all instruments on a single mission should ideally be tested with the same suite of relevant analogue materials. The ISAR lithothéque aims to fulfill this role by providing suitable materials to instrument teams [1]. The lithothèque is accompanied by an online database of all relevant structural, textural, and geochemical data (www.isar.cnrs-orleans.fr).The data base will also be available during missions to aid interpretation of data obtained in situ. Mars is the immediate goal for MSL-2011 and the new international Mars 2018 mission. The lithothèque thus presently contains relevant Mars-analogue rock and mineral samples, a preliminary range of which is now available to the scientific community for instrument testing [2]. The preliminary group of samples covers a range of lithologies to be found on Mars, especially those in Noachain/Hesperian terrains where MSL will land (Gale Crater) and where the 2018 landing site will most likely be located. It includes a variety of basalts (tephrite, primitive basalt, silicified basalt; plus cumulates), komatiites, artificially synthesized martian basalts [3], volcanic sands, a banded iron formation, carbonates associated with volcanic lithologies and hydrothermalism, the clay Nontronite, and hydrothermal cherts. Some of the silicified volcanic sands contain traces of early life that are good analogues for potential martian life [4]. [1] Westall F. et al., LPI contribution 1608, 1346, 42nd LPSC, 2011; [2] Bost N. et al., in review (Icarus); [3] Bost N. et al., in review (Meteoritics); [4] Westall et al., 2011, Planetary and Space

  14. Angled-focused 45 MHz PMN-PT single element transducer for intravascular ultrasound imaging.

    Science.gov (United States)

    Yoon, Sangpil; Williams, Jay; Kang, Bong Jin; Yoon, Changhan; Cabrera-Munoz, Nestor; Jeong, Jong Seob; Lee, Sang Goo; Shung, K Kirk; Kim, Hyung Ham

    2015-06-01

    A transducer with an angled and focused aperture for intravascular ultrasound imaging has been developed. The acoustic stack for the angled-focused transducer was made of PMN-PT single crystal with one matching layer, one protective coating layer, and a highly damped backing layer. It was then press-focused to a desired focal length and inserted into a thin needle housing with an angled tip. A transducer with an angled and unfocused aperture was also made, following the same fabrication procedure, to compare the performance of the two transducers. The focused and unfocused transducers were tested to measure their center frequencies, bandwidths, and spatial resolutions. Lateral resolution of the angled-focused transducer (AFT) improved more than two times compared to that of the angled-unfocused transducer (AUT). A tissue-mimicking phantom in water and a rabbit aorta tissue sample in rabbit blood were scanned using AFT and AUT. Imaging with AFT offered improved contrast, over imaging with AUT, of the tissue-mimicking phantom and the rabbit aorta tissue sample by 23 dB and 8 dB, respectively. The results show that AFT has strong potential to provide morphological and pathological information of coronary arteries with high resolution and high contrast.

  15. Objective, comparative assessment of the penetration depth of temporal-focusing microscopy for imaging various organs

    Science.gov (United States)

    Rowlands, Christopher J.; Bruns, Oliver T.; Bawendi, Moungi G.; So, Peter T. C.

    2015-06-01

    Temporal focusing is a technique for performing axially resolved widefield multiphoton microscopy with a large field of view. Despite significant advantages over conventional point-scanning multiphoton microscopy in terms of imaging speed, the need to collect the whole image simultaneously means that it is expected to achieve a lower penetration depth in common biological samples compared to point-scanning. We assess the penetration depth using a rigorous objective criterion based on the modulation transfer function, comparing it to point-scanning multiphoton microscopy. Measurements are performed in a variety of mouse organs in order to provide practical guidance as to the achievable penetration depth for both imaging techniques. It is found that two-photon scanning microscopy has approximately twice the penetration depth of temporal-focusing microscopy, and that penetration depth is organ-specific; the heart has the lowest penetration depth, followed by the liver, lungs, and kidneys, then the spleen, and finally white adipose tissue.

  16. 2D image registration using focused mutual information for application in dentistry.

    Science.gov (United States)

    Jacquet, W; Nyssen, E; Bottenberg, P; Truyen, B; de Groen, P

    2009-06-01

    Spatial alignment of image data is a common task in computer vision and medical imaging. This should preferentially be done with minimal intervention of an operator. Similarity measures with origin in the information theory such as mutual information (MI) have proven to be robust registration criteria for this purpose. Intra-oral radiographs can be considered images of piecewise rigid objects. Teeth and jaws are rigid but can be displaced with respect to each other. Therefore MI criteria combined with affine deformations tend to fail, when teeth and jaws move with respect to each other between image acquisitions. In this paper, we consider a focused weighing of pixels in the reference image. The resulting criterion, focused mutual information (FMI) is an adequate tool for the registration of rigid parts of a scene. We also show that the use of FMI is more robust for the subtraction of lateral radiographs of teeth, than MI confined to a region of interest. Furthermore, the criterion allows the follow-up of small carious lesions when upper and lower jaw moved between the acquisition of test and reference image.

  17. Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy.

    Science.gov (United States)

    Bushby, Andrew J; P'ng, Kenneth M Y; Young, Robert D; Pinali, Christian; Knupp, Carlo; Quantock, Andrew J

    2011-06-01

    In this protocol, we describe a 3D imaging technique known as 'volume electron microscopy' or 'focused ion beam scanning electron microscopy (FIB/SEM)' applied to biological tissues. A scanning electron microscope equipped with a focused gallium ion beam, used to sequentially mill away the sample surface, and a backscattered electron (BSE) detector, used to image the milled surfaces, generates a large series of images that can be combined into a 3D rendered image of stained and embedded biological tissue. Structural information over volumes of tens of thousands of cubic micrometers is possible, revealing complex microanatomy with subcellular resolution. Methods are presented for tissue processing, for the enhancement of contrast with osmium tetroxide/potassium ferricyanide, for BSE imaging, for the preparation and platinum deposition over a selected site in the embedded tissue block, and for sequential data collection with ion beam milling; all this takes approximately 90 h. The imaging conditions, procedures for alternate milling and data acquisition and techniques for processing and partitioning the 3D data set are also described; these processes take approxiamtely 30 h. The protocol is illustrated by application to developing chick cornea, in which cells organize collagen fibril bundles into complex, multilamellar structures essential for transparency in the mature connective tissue matrix. The techniques described could have wide application in a range of fields, including pathology, developmental biology, microstructural anatomy and regenerative medicine.

  18. Intricate Plasma-Scattered Images and Spectra of Focused Femtosecond Laser Pulses

    Science.gov (United States)

    Ooi, C. H. Raymond; Talib, Md. Ridzuan

    2016-08-01

    We report on some interesting phenomena in the focusing and scattering of femtosecond laser pulses in free space that provide insights on intense laser plasma interactions. The scattered image in the far field is analyzed and the connection with the observed structure of the plasma at the focus is discussed. We explain the physical mechanisms behind the changes in the colorful and intricate image formed by scattering from the plasma for different compressions, as well as orientations of plano-convex lens. The laser power does not show significant effect on the images. The pulse repetition rate above 500 Hz can affect the image through slow dynamics The spectrum of each color in the image shows oscillatory peaks due to interference of delayed pulse that correlate with the plasma length. Spectral lines of atomic species are identified and new peaks are observed through the white light emitted by the plasma spot. We find that an Ar gas jet can brighten the white light of the plasma spot and produce high resolution spectral peaks. The intricate image is found to be extremely sensitive and this is useful for applications in sensing microscale objects.

  19. Theranostic applications of carbon nanomaterials in cancer: Focus on imaging and cargo delivery.

    Science.gov (United States)

    Chen, Daiqin; Dougherty, Casey A; Zhu, Kaicheng; Hong, Hao

    2015-07-28

    Carbon based nanomaterials have attracted significant attention over the past decades due to their unique physical properties, versatile functionalization chemistry, and biological compatibility. In this review, we will summarize the current state-of-the-art applications of carbon nanomaterials in cancer imaging and drug delivery/therapy. The carbon nanomaterials will be categorized into fullerenes, nanotubes, nanohorns, nanodiamonds, nanodots and graphene derivatives based on their morphologies. The chemical conjugation/functionalization strategies of each category will be introduced before focusing on their applications in cancer imaging (fluorescence/bioluminescence, magnetic resonance (MR), positron emission tomography (PET), single-photon emission computed tomography (SPECT), photoacoustic, Raman imaging, etc.) and cargo (chemo/gene/therapy) delivery. The advantages and limitations of each category and the potential clinical utilization of these carbon nanomaterials will be discussed. Multifunctional carbon nanoplatforms have the potential to serve as optimal candidates for image-guided delivery vectors for cancer.

  20. 3D Image Acquisition System Based on Shape from Focus Technique

    Directory of Open Access Journals (Sweden)

    Pierre Gouton

    2013-04-01

    Full Text Available This paper describes the design of a 3D image acquisition system dedicated to natural complex scenes composed of randomly distributed objects with spatial discontinuities. In agronomic sciences, the 3D acquisition of natural scene is difficult due to the complex nature of the scenes. Our system is based on the Shape from Focus technique initially used in the microscopic domain. We propose to adapt this technique to the macroscopic domain and we detail the system as well as the image processing used to perform such technique. The Shape from Focus technique is a monocular and passive 3D acquisition method that resolves the occlusion problem affecting the multi-cameras systems. Indeed, this problem occurs frequently in natural complex scenes like agronomic scenes. The depth information is obtained by acting on optical parameters and mainly the depth of field. A focus measure is applied on a 2D image stack previously acquired by the system. When this focus measure is performed, we can create the depth map of the scene.

  1. Robust Automatic Focus Algorithm for Low Contrast Images Using a New Contrast Measure

    Directory of Open Access Journals (Sweden)

    Jinshan Tang

    2011-08-01

    Full Text Available Low contrast images, suffering from a lack of sharpness, are easily influenced by noise. As a result, many local false peaks may be generated in contrast measurements, making it difficult for the camera’s passive auto-focus system to perform its function of locating the focused peak. In this paper, a new passive auto-focus algorithm is proposed to address this problem. First, a noise reduction preprocessing is introduced to make our algorithm robust to both additive noise and multiplicative noise. Then, a new contrast measure is presented to bring in local false peaks, ensuring the presence of a well defined focused peak. In order to gauge the performance of our algorithm, a modified peak search algorithm is used in the experiments. The experimental results from an actual digital camera validate the effectiveness of our proposed algorithm.

  2. A time domain phase-gradient based ISAR autofocus algorithm

    CSIR Research Space (South Africa)

    Nel, W

    2011-10-01

    Full Text Available -order polynomial typically removes the significant remaining phase error in the data. Fig 4. Phase error estimated (red) on first iteration using a low-pass filter. In green the effect of not having chosen any stable scatterers can be seen. For clarity..., the green plot is offset artificially by ??. Fig 5. Autofocused image after first iteration. A low-pass filter was used to estimate error. This second iteration is akin to that of PGA, where window size is decreased to control the filter bandwidth...

  3. Progress of Focusing X-ray and Gamma-ray Optics for Small Animal Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Pivovaroff, M J; Funk, T; Barber, W C; Ramsey, B D; Hasegawa, B H

    2005-08-05

    Significant effort is currently being devoted to the development of noninvasive imaging systems that allow in vivo assessment of biological and biomolecular interactions in mice and other small animals. Ideally, one would like to discern these functional and metabolic relationships with in vivo radionuclide imaging at spatial resolutions approaching those that can be obtained using the anatomical imaging techniques (i.e., <100 {micro}m), which would help to answer outstanding questions in many areas of biomedicine. In this paper, we report progress on our effort to develop high-resolution focusing X-ray and gamma-ray optics for small-animal radionuclide imaging. The use of reflective optics, in contrast to methods that rely on absorptive collimation like single- or multiple-pinhole cameras, decouples spatial resolution from sensitivity (efficiency). Our feasibility studies have refined and applied ray-tracing routines to design focusing optics for small animal studies. We also have adopted a replication technique to manufacture the X-ray mirrors, and which in experimental studies have demonstrated a spatial resolution of {approx}190 {micro}m. We conclude that focusing optics can be designed and fabricated for gamma-ray energies, and with spatial resolutions, and field of view suitable for in vivo biological studies. While the efficiency of a single optic is limited, fabrication methods now are being developed that may make it possible to develop imaging systems with multiple optics that could collect image data over study times that would be practical for performing radionuclide studies of small animals.

  4. Two-color temporal focusing multiphoton excitation imaging with tunable-wavelength excitation

    Science.gov (United States)

    Lien, Chi-Hsiang; Abrigo, Gerald; Chen, Pei-Hsuan; Chien, Fan-Ching

    2017-02-01

    Wavelength tunable temporal focusing multiphoton excitation microscopy (TFMPEM) is conducted to visualize optical sectioning images of multiple fluorophore-labeled specimens through the optimal two-photon excitation (TPE) of each type of fluorophore. The tunable range of excitation wavelength was determined by the groove density of the grating, the diffraction angle, the focal length of lenses, and the shifting distance of the first lens in the beam expander. Based on a consideration of the trade-off between the tunable-wavelength range and axial resolution of temporal focusing multiphoton excitation imaging, the presented system demonstrated a tunable-wavelength range from 770 to 920 nm using a diffraction grating with groove density of 830 lines/mm. TPE fluorescence imaging examination of a fluorescent thin film indicated that the width of the axial confined excitation was 3.0±0.7 μm and the shifting distance of the temporal focal plane was less than 0.95 μm within the presented wavelength tunable range. Fast different wavelength excitation and three-dimensionally rendered imaging of Hela cell mitochondria and cytoskeletons and mouse muscle fibers were demonstrated. Significantly, the proposed system can improve the quality of two-color TFMPEM images through different excitation wavelengths to obtain higher-quality fluorescent signals in multiple-fluorophore measurements.

  5. The Focusing Optics X-ray Solar Imager Small Explorer Concept Mission

    Science.gov (United States)

    Christe, Steven; Shih, Albert Y.; Dennis, Brian R.; Glesener, Lindsay; Krucker, Sam; Saint-Hilaire, Pascal; Gubarev, Mikhail; Ramsey, Brian

    2016-05-01

    We present the FOXSI (Focusing Optics X-ray Solar Imager) small explorer (SMEX) concept, a mission dedicated to studying particle acceleration and energy release on the Sun. FOXSI is designed as a 3-axis stabilized spacecraft in low-Earth orbit making use of state-of-the-art grazing incidence focusing optics combined withpixelated solid-state detectors, allowing for direct imaging of solar X-rays. The current design being studied features multiple telescopes with a 14 meter focal length enabled by a deployable boom.FOXSI will observe the Sun in the 3-100 keV energy range. The FOXSI imaging concept has already been tested on two sounding rocket flights, in 2012 and 2014 and on the HEROES balloon payload flight in 2013. FOXSI will image the Sun with an angular resolution of 5'', a spectral resolution of 0.5 keV, and sub-second temporal resolution. FOXSI is a direct imaging spectrometer with high dynamic range and sensitivity and will provide a brand-new perspective on energy release on the Sun. We describe the mission and its science objectives.

  6. The effect of aberrations on objectively assessed image quality and depth of focus.

    Science.gov (United States)

    Águila-Carrasco, Antonio J Del; Read, Scott A; Montés-Micó, Robert; Iskander, D Robert

    2017-02-01

    The effects of aberrations on image quality and the objectively assessed depth of focus (DoF) were studied. Aberrometry data from 80 young subjects with a range of refractive errors was used for computing the visual Strehl ratio based on the optical transfer function (VSOTF), and then, through-focus simulations were performed in order to calculate the objective DoF (using two different relative thresholds of 50% and 80%; and two different pupil diameters) and the image quality (the peak VSOTF). Both lower order astigmatism and higher order aberration (HOA) terms up to the fifth radial order were considered. The results revealed that, of the HOAs, the comatic terms (third and fifth order) explained most of the variations of the DoF and the image quality in this population of subjects. Furthermore, computer simulations demonstrated that the removal of these terms also had a significant impact on both DoF and the peak VSOTF. Knowledge about the relationship between aberrations, DoF, image quality, and their interactions is essential in optical designs aiming to produce large values of DoF while maintaining an acceptable level of image quality. Comatic aberration terms appear to contribute strongly towards the configuration of both of these visually important parameters.

  7. Countering beam divergence effects with focused segmented scintillators for high DQE megavoltage active matrix imagers

    Science.gov (United States)

    Liu, Langechuan; Antonuk, Larry E.; Zhao, Qihua; El-Mohri, Youcef; Jiang, Hao

    2012-08-01

    The imaging performance of active matrix flat-panel imagers designed for megavoltage imaging (MV AMFPIs) is severely constrained by relatively low x-ray detection efficiency, which leads to a detective quantum efficiency (DQE) of only ∼1%. Previous theoretical and empirical studies by our group have demonstrated the potential for addressing this constraint through the utilization of thick, two-dimensional, segmented scintillators with optically isolated crystals. However, this strategy is constrained by the degradation of high-frequency DQE resulting from spatial resolution loss at locations away from the central beam axis due to oblique incidence of radiation. To address this challenge, segmented scintillators constructed so that the crystals are individually focused toward the radiation source are proposed and theoretically investigated. The study was performed using Monte Carlo simulations of radiation transport to examine the modulation transfer function and DQE of focused segmented scintillators with thicknesses ranging from 5 to 60 mm. The results demonstrate that, independent of scintillator thickness, the introduction of focusing largely restores spatial resolution and DQE performance otherwise lost in thick, unfocused segmented scintillators. For the case of a 60 mm thick BGO scintillator and at a location 20 cm off the central beam axis, use of focusing improves DQE by up to a factor of ∼130 at non-zero spatial frequencies. The results also indicate relatively robust tolerance of such scintillators to positional displacements, of up to 10 cm in the source-to-detector direction and 2 cm in the lateral direction, from their optimal focusing position, which could potentially enhance practical clinical use of focused segmented scintillators in MV AMFPIs.

  8. From Image Processing to Classification: 1. Modelling Disturbances of Isoelectric Focusing Patterns

    DEFF Research Database (Denmark)

    Jensen, Karsten; Søndergaard, I.; Skovgaard, I. M.

    1995-01-01

    In order to optimize the conditions for evaluation of isoelectric focusing (IEF) patterns by digital image processing, the sources of error in determination of the pi values were analyzed together with the influence of a varying background. The effects of band distortions, in the spectra...... of the individual lanes, were examined. In order to minimize the effect of these distortions, optimal conditions for handling IEF patterns by digital image processing were elucidated. The systematic part of the global deformation on the gels was investigated and an algorithm was developed by which it was possible...

  9. Multiphoton microscopic imaging of fibrotic focus in invasive ductal carcinoma of the breast

    Science.gov (United States)

    Chen, Sijia; Nie, Yuting; Lian, Yuane; Wu, Yan; Fu, Fangmeng; Wang, Chuan; Zhuo, Shuangmu; Chen, Jianxin

    2014-11-01

    During the proliferation of breast cancer, the desmoplastic can evoke a fibrosis response by invading healthy tissue. Fibrotic focus (FF) in invasive ductal carcinoma (IDC) of the breast had been reported to be associated with significantly poorer survival rate than IDC without FF. As an important prognosis indicator, it's difficult to obtain the exact fibrotic information from traditional detection method such as mammography. Multiphoton imaging based on two-photon excited fluorescence (TPEF) and second-harmonic generation (SHG) has been recently employed for microscopic examination of unstained tissue. In this study, multiphoton microscopy (MPM) was used to image the fibrotic focus in invasive ductal carcinoma tissue. The morphology and distribution of collagen in fibrotic focus can be demonstrated by the SHG signal. Variation of collagen between IDC with and without FF will be examined and further characterized, which may be greatly related to the metastasis of breast cancer. Our result suggested that the MPM can be efficient in identifying and locating the fibrotic focus in IDC. Combining with the pathology analysis and other detecting methods, MPM owns potential in becoming an advanced histological tool for detecting the fibrotic focus in IDC and collecting prognosis information, which may guide the subsequent surgery option and therapy procedure for patients.

  10. Bifractal focusing and imaging properties of Thue-Morse Zone Plates.

    Science.gov (United States)

    Ferrando, Vicente; Giménez, Fernando; Furlan, Walter D; Monsoriu, Juan A

    2015-07-27

    We present a new family of Zone Plates (ZPs) designed using the Thue-Morse sequence. The focusing and imaging properties of these aperiodic diffractive lenses coined Thue-Morse Zone Plates (TMZPs) are examined. It is demonstrated that TMZPs produce a pair of self-similar and equally intense foci along the optical axis. As a consequence of this property, under broadband illumination, a TMZP produces two foci with an extended depth of focus and a strong reduction of the chromatic aberration compared with conventional periodic ZPs. This distinctive optical characteristic is experimentally confirmed.

  11. Curvelet based automatic segmentation of supraspinatus tendon from ultrasound image: a focused assistive diagnostic method.

    Science.gov (United States)

    Gupta, Rishu; Elamvazuthi, Irraivan; Dass, Sarat Chandra; Faye, Ibrahima; Vasant, Pandian; George, John; Izza, Faizatul

    2014-12-04

    Disorders of rotator cuff tendons results in acute pain limiting the normal range of motion for shoulder. Of all the tendons in rotator cuff, supraspinatus (SSP) tendon is affected first of any pathological changes. Diagnosis of SSP tendon using ultrasound is considered to be operator dependent with its accuracy being related to operator's level of experience. The automatic segmentation of SSP tendon ultrasound image was performed to provide focused and more accurate diagnosis. The image processing techniques were employed for automatic segmentation of SSP tendon. The image processing techniques combines curvelet transform and mathematical concepts of logical and morphological operators along with area filtering. The segmentation assessment was performed using true positives rate, false positives rate and also accuracy of segmentation. The specificity and sensitivity of the algorithm was tested for diagnosis of partial thickness tears (PTTs) and full thickness tears (FTTs). The ultrasound images of SSP tendon were taken from medical center with the help of experienced radiologists. The algorithm was tested on 116 images taken from 51 different patients. The accuracy of segmentation of SSP tendon was calculated to be 95.61% in accordance with the segmentation performed by radiologists, with true positives rate of 91.37% and false positives rate of 8.62%. The specificity and sensitivity was found to be 93.6%, 94% and 95%, 95.6% for partial thickness tears and full thickness tears respectively. The proposed methodology was successfully tested over a database of more than 116 US images, for which radiologist assessment and validation was performed. The segmentation of SSP tendon from ultrasound images helps in focused, accurate and more reliable diagnosis which has been verified with the help of two experienced radiologists. The specificity and sensitivity for accurate detection of partial and full thickness tears has been considerably increased after segmentation when

  12. A Novel Multi-Focus Image Fusion Method Based on Stochastic Coordinate Coding and Local Density Peaks Clustering

    Directory of Open Access Journals (Sweden)

    Zhiqin Zhu

    2016-11-01

    Full Text Available The multi-focus image fusion method is used in image processing to generate all-focus images that have large depth of field (DOF based on original multi-focus images. Different approaches have been used in the spatial and transform domain to fuse multi-focus images. As one of the most popular image processing methods, dictionary-learning-based spare representation achieves great performance in multi-focus image fusion. Most of the existing dictionary-learning-based multi-focus image fusion methods directly use the whole source images for dictionary learning. However, it incurs a high error rate and high computation cost in dictionary learning process by using the whole source images. This paper proposes a novel stochastic coordinate coding-based image fusion framework integrated with local density peaks. The proposed multi-focus image fusion method consists of three steps. First, source images are split into small image patches, then the split image patches are classified into a few groups by local density peaks clustering. Next, the grouped image patches are used for sub-dictionary learning by stochastic coordinate coding. The trained sub-dictionaries are combined into a dictionary for sparse representation. Finally, the simultaneous orthogonal matching pursuit (SOMP algorithm is used to carry out sparse representation. After the three steps, the obtained sparse coefficients are fused following the max L1-norm rule. The fused coefficients are inversely transformed to an image by using the learned dictionary. The results and analyses of comparison experiments demonstrate that fused images of the proposed method have higher qualities than existing state-of-the-art methods.

  13. Medical imaging for congenital anomalies of the lung. Focused on tracheobronchial and parenchymal anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Kohda, Ehiichi; Shiraga, Nobuyuki; Higuchi, Mutsumi; Ishibashi, Ryouchi [Tachikawa Hospital, Tokyo (Japan)

    2003-02-01

    This is a review of medical imaging studies for congenital anomalies of the lung focused on tracheobronchial and parenchymal anomalies. It is important to know the findings of these developmental anomalies, because they are frequently manifested as infectious diseases or mass. Documented details are pulmonary agenesis, aplasia, pulmonary hypoplasia, tracheal agenesis, bridging bronchus, tracheal bronchus, congenital tracheal stenosis, bronchial atresia, bronchobiliary fistula, bronchogenic cyst, bronchopulmonary sequestration, congenital cystic adenomatoid malformation, and pulmonary lymphangiectasia. (author)

  14. Multi-focus image fusion based on the non-subsampled contourlet transform

    Science.gov (United States)

    Adu, Jianhua; Wang, Minghui; Wu, Zhenya; Zhou, Zhongli

    2012-09-01

    In this paper, a new image fusion algorithm based on non-subsampled contourlet transform (NSCT) is proposed for the fusion of multi-focus images. The selection of different subband coefficients obtained by the NSCT decomposition is critical to image fusion. So, in this paper, firstly, original images are decomposed into different frequency subband coefficients by NSCT. Secondly, the selection of the low-frequency subband coefficients and the bandpass directional subband coefficients is discussed in detail. For the selection of the low-frequency subband coefficients, the non-negative matrix factorization (NMF) method is adopted. For the selection of bandpass directional subband coefficients, a regional cross-gradient method that selects the coefficients according to the minimum of the regional cross-gradient is proposed. Finally, the fused image is obtained by performing the inverse NSCT on the combined coefficients. The experimental results show that the proposed fusion algorithm can achieve significant results in getting a new image where all parts are sharp.

  15. High intensity focused ultrasound (HIFU) focal spot localization using harmonic motion imaging (HMI).

    Science.gov (United States)

    Han, Yang; Hou, Gary Yi; Wang, Shutao; Konofagou, Elisa

    2015-08-07

    Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU monitoring technique that utilizes radiation-force-induced localized oscillatory displacement. HMIFU has been shown to correctly identify the formation and extent of HIFU thermal ablation lesions. However a significant problem remains in identifying the location of the HIFU focus, which is necessary for treatment planning. In this study, the induced displacement was employed to localize the HIFU focal spot inside the tissue prior to treatment. Feasibility was shown with two separate systems. The 1D HMIFU system consisted of a HIFU transducer emitting an amplitude-modulated HIFU beam for mechanical excitation and a confocal single-element, pulse-echo transducer for simultaneous RF acquisition. The 2D HIFU system consists of a HIFU phased array, and a co-axial imaging phased array for simultaneous imaging. Initial feasibility was first performed on tissue-mimicking gelatin phantoms and the focal zone was defined as the region corresponding to the -3dB full width at half maximum of the HMI displacement. Using the same parameters, in vitro experiments were performed in canine liver specimens to compare the defined focal zone with the lesion. In vitro measurements showed good agreement between the HMI predicted focal zone and the induced HIFU lesion location. HMIFU was experimentally shown to be capable of predicting and tracking the focal region in both phantoms and in vitro tissues. The accuracy of focal spot localization was evaluated by comparing with the lesion location in post-ablative tissues, with a R(2) = 0.821 at p tissue ablation and can be fully integrated into any HMI

  16. Multi-focus image fusion algorithm based on adaptive PCNN and wavelet transform

    Science.gov (United States)

    Wu, Zhi-guo; Wang, Ming-jia; Han, Guang-liang

    2011-08-01

    Being an efficient method of information fusion, image fusion has been used in many fields such as machine vision, medical diagnosis, military applications and remote sensing. In this paper, Pulse Coupled Neural Network (PCNN) is introduced in this research field for its interesting properties in image processing, including segmentation, target recognition et al. and a novel algorithm based on PCNN and Wavelet Transform for Multi-focus image fusion is proposed. First, the two original images are decomposed by wavelet transform. Then, based on the PCNN, a fusion rule in the Wavelet domain is given. This algorithm uses the wavelet coefficient in each frequency domain as the linking strength, so that its value can be chosen adaptively. Wavelet coefficients map to the range of image gray-scale. The output threshold function attenuates to minimum gray over time. Then all pixels of image get the ignition. So, the output of PCNN in each iteration time is ignition wavelet coefficients of threshold strength in different time. At this moment, the sequences of ignition of wavelet coefficients represent ignition timing of each neuron. The ignition timing of PCNN in each neuron is mapped to corresponding image gray-scale range, which is a picture of ignition timing mapping. Then it can judge the targets in the neuron are obvious features or not obvious. The fusion coefficients are decided by the compare-selection operator with the firing time gradient maps and the fusion image is reconstructed by wavelet inverse transform. Furthermore, by this algorithm, the threshold adjusting constant is estimated by appointed iteration number. Furthermore, In order to sufficient reflect order of the firing time, the threshold adjusting constant αΘ is estimated by appointed iteration number. So after the iteration achieved, each of the wavelet coefficient is activated. In order to verify the effectiveness of proposed rules, the experiments upon Multi-focus image are done. Moreover

  17. Classification of objects in ISAR imagery using artificial neural networks

    Science.gov (United States)

    Fechner, Thomas; Hantsche, Ruediger; Tanger, Ralf

    1996-03-01

    The motive of our work is to achieve aspect angle and motion independent robust classification of relevant objects in inverse synthetic aperture radar imagery. It is required that the classification decision should incorporate an estimate of confidence in order to reject weak decisions due to critical aspect angles or unknown objects. The proposed architecture employs a cascaded combination of an unsupervised and a supervised trained neural network. The unsupervised trained Self-Organizing Feature Map is used for object segmentation by clustering a 2D feature space and the supervised multi-layer perceptron (MLP) classifier performs the object recognition based on extracted features from the segmented object. Various features characterizing the geometrical appearance and the scatterer distribution of the objects are investigated and a combination of features, which maximize the MLP classification rate, is selected. For comparison purposes a nearest neighbor classification approach is also considered. A grouping mechanism which groups together similar views of the object, reduces the degrees of freedom of the classification process by using its own adapted classifier for each group. On simulated noisy images a recognition rates over 90% for 10 different object classes has been achieved.

  18. Compound focusing mirror and X-ray waveguide optics for coherent imaging and nano-diffraction.

    Science.gov (United States)

    Salditt, Tim; Osterhoff, Markus; Krenkel, Martin; Wilke, Robin N; Priebe, Marius; Bartels, Matthias; Kalbfleisch, Sebastian; Sprung, Michael

    2015-07-01

    A compound optical system for coherent focusing and imaging at the nanoscale is reported, realised by high-gain fixed-curvature elliptical mirrors in combination with X-ray waveguide optics or different cleaning apertures. The key optical concepts are illustrated, as implemented at the Göttingen Instrument for Nano-Imaging with X-rays (GINIX), installed at the P10 coherence beamline of the PETRA III storage ring at DESY, Hamburg, and examples for typical applications in biological imaging are given. Characteristic beam configurations with the recently achieved values are also described, meeting the different requirements of the applications, such as spot size, coherence or bandwidth. The emphasis of this work is on the different beam shaping, filtering and characterization methods.

  19. Quantitative index imaging of coculture cells by scanning focused refractive index microscopy

    Science.gov (United States)

    Sun, Teng-Qian; Ye, Qing; Hu, Fen; Liu, Shi-ke; Wang, Xiao-Wan; Wang, Jin; Deng, Zhi-Chao; Mei, Jian-Chun; Zhou, Wen-Yuan; Zhang, Chun-Ping; Wang, Xin-Yu; Pan, Lei-Ting; Tian, Jian-Guo

    2016-08-01

    We report the quantitative refractive index (RI) imaging of cocultured cells in their living environment by scanning focused refractive index microscopy (SFRIM). Mouse microglial cells and synovial cells are cocultured on the top surface of a trapezoid prism. The RI imaging of living cells is obtained in a reflection-type method. The RI information is deduced with the simple derivative total internal reflection method, where a complex retrieval algorithm or reconstruction process is unnecessary. The outline of each cell is determined according to the RI value compared with that of the immersion liquid. The cocultured cells can be discriminated in the RI image. The measurement is nondestructive and label-free. The experimental results prove that SFRIM is a promising tool in the field of biological optics.

  20. Non-contact optoacoustic imaging with focused air-coupled transducers

    Energy Technology Data Exchange (ETDEWEB)

    Deán-Ben, X. Luís [Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg (Germany); Pang, Genny A.; Razansky, Daniel, E-mail: dr@tum.de [Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, Neuherberg (Germany); School of Medicine, Technische Universität München (TUM), Munich (Germany); Montero de Espinosa, Francisco [CSIC, Institute of Physics and Communication Technologies, Madrid (Spain)

    2015-08-03

    Non-contact optoacoustic imaging employing raster-scanning of a spherically focused air-coupled ultrasound transducer is showcased herein. Optoacoustic excitation with laser fluence within the maximal permissible human exposure limits in the visible and near-infrared spectra is applied to objects with characteristic dimensions smaller than 1 mm and absorption properties representative of the whole blood at near-infrared wavelengths, and these signals are shown to be detectable without contact to the sample using an air-coupled transducer with reasonable signal averaging. Optoacoustic images of vessel-mimicking tubes embedded in an agar phantom captured with this non-contact sensing technique are also showcased. These initial results indicate that an air-coupled ultrasound detection approach can be suitable for non-contact biomedical imaging with optoacoustics.

  1. Deep skin structural and microcirculation imaging with extended-focus OCT

    Science.gov (United States)

    Blatter, Cedric; Grajciar, Branislav; Huber, Robert; Leitgeb, Rainer A.

    2012-02-01

    We present an extended focus OCT system for dermatologic applications that maintains high lateral resolution over a large depth range by using Bessel beam illumination. More, Bessel beams exhibit a self-reconstruction property that is particularly useful to avoid shadowing from surface structures such as hairs. High lateral resolution and high-speed measurement, thanks to a rapidly tuning swept source, allows not only for imaging of small skin structures in depth but also for comprehensive visualization of the small capillary network within the human skin in-vivo. We use this information for studying temporal vaso-responses to hypothermia. In contrast to other perfusion imaging methods such as laser Doppler imaging (LDI), OCT gives specific access to vascular responses in different vascular beds in depth.

  2. Applications of focused MeV light ion beams for high resolution channeling contrast imaging

    Energy Technology Data Exchange (ETDEWEB)

    Jamieson, D.N.; Breese, M.B.H.; Prawer, S.; Dooley, S.P.; Allen, M.G.; Bettiol, A.A.; Saint, A. [Melbourne Univ., Parkville, VIC (Australia). School of Physics; Ryan, C.G. [Commonwealth Scientific and Industrial Research Organisation (CSIRO), North Ryde, NSW (Australia). Div. of Exploration Geoscience

    1993-12-31

    The technique of Nuclear Microscopy, utilizing a focused ion probe of typically MeV H{sup +} or He{sup +} ions, can produce images where the contrast depends on typical Ion Beam Analysis (lBA) processes. The probe forming lens system usually utilizes strong focusing, precision magnetic quadrupole lenses and the probe is scanned over the target to produce images. Originally, this imaging technique was developed to utilize backscattered particles with incident beam currents typically of a few nA, and the technique became known as Channeling Contrast Microscopy (CCM). Recently, the technique has been developed further to utilize the forward scattering of ions incident along a major crystal axis in thin crystals. This technique is known as Channeling Scanning Transmission Ion Microscopy (CSTIM). Since nearly all incident ions are detected, CSTIM is highly efficient and very low beam currents are sufficient for imaging, typically as low as a few fA. This allows probes as small as 50 nm to be used. In this paper we briefly review the recent applications of these emerging techniques to a variety of single crystal materials (authors). 13 refs., 5 figs.

  3. Bionic optical imaging system with aspheric solid-liquid mixed variable-focus lens

    Science.gov (United States)

    Du, Jia-Wei; Wang, Xuan-Yin; Liang, Dan

    2016-02-01

    A bionic optical imaging system with an aspheric solid-liquid mixed variable-focus lens was designed and fabricated. The entire system mainly consisted of a doublet lens, a solid-liquid mixed variable-focus lens, a connecting part, and a CCD imaging device. To mimic the structure of the crystalline lens, the solid-liquid mixed variable-focus lens consisted of a polydimethylsiloxane (PDMS) lens, a polymethyl methacrylate lens, and the liquid of ethyl silicone oil. By pumping liquid in or out of the cavity using a microinjector, the curvatures of the front and rear surfaces of the PDMS lens were varied, resulting in a change of focal length. The overall structure of the system was presented, as well as a detailed description of the solid-liquid mixed variable-focus lens, material, and fabrication process. Under different injection volumes, the deformation of the PDMS lens was measured and simulated, pictures were captured, and the optical performance was analyzed in simulations and experiments. The focal length of the system ranged from 25.05 to 14.61 mm, and the variation of the diopter was 28.5D, which was larger than that of the human eye.

  4. The sporting body: body image and eating disorder symptomatology among female athletes from leanness focused and nonleanness focused sports.

    Science.gov (United States)

    Kong, Peiling; Harris, Lynne M

    2015-01-01

    Female athletes experience pressure to conform to social and sporting norms concerning body weight. This study compared general and sporting body dissatisfaction and disordered eating symptomatology among 320 elite, recreational, and noncompetitive female athletes aged 17 to 30 years competing in leanness focused sports and nonleanness focused sports. Participants completed an online questionnaire including demographic questions, the Eating Attitudes Test, and the Figure Rating Scale. Athletes from leanness focused sports reported higher levels of body dissatisfaction and greater disordered eating symptomatology regardless of participation level. Elite athletes reported higher levels of body dissatisfaction and greater disordered eating symptomatology regardless of sport type, and differences between recreational and noncompetitive athletes were not found. More than 60% of elite athletes from leanness focused and nonleanness focused sports reported pressure from coaches concerning body shape. The findings have important implications for identifying risk factors for eating disorders among female athletes, where athletes who compete at elite level and those who compete in leanness focused sports at any level may be at higher risk for developing eating disorders.

  5. Structural Health Monitoring Using Lamb Wave Reflections and Total Focusing Method for Image Reconstruction

    Science.gov (United States)

    Muller, Aurelia; Robertson-Welsh, Bradley; Gaydecki, Patrick; Gresil, Matthieu; Soutis, Constantinos

    2017-04-01

    This investigation aimed to adapt the total focusing method (TFM) algorithm (originated from the synthetic aperture focusing technique in digital signal processing) to accommodate a circular array of piezoelectric sensors (PZT) and characterise defects using guided wave signals for the development of a structural health monitoring system. This research presents the initial results of a broader study focusing on the development of a structural health monitoring (SHM) guided wave system for advance carbon fibre reinforced plastic (CFRP) composite materials. The current material investigated was an isotropic (aluminium) square plate with 16 transducers operating successively as emitter or sensor in pitch and catch configuration enabling the collection of 240 signals per assessment. The Lamb wave signals collected were tuned on the symmetric fundamental mode with a wavelength of 17 mm, by setting the excitation frequency to 300 kHz. The initial condition for the imaging system, such as wave speed and transducer position, were determined with post processing of the baseline signals through a method involving the identification of the waves reflected from the free edge of the plate. The imaging algorithm was adapted to accommodate multiple transmitting transducers in random positions. A circular defect of 10 mm in diameter was drilled in the plate, which is similar to the delamination size introduced by a low velocity impact event in a composite plate. Images were obtained by applying the TFM to the baseline signals, Test 1 data (corresponding to the signals obtained after introduction of the defect) and to the data derived from the subtraction of the baseline to the Test 1 signals. The result shows that despite the damage diameter being 40 % smaller than the wavelength, the image (of the subtracted baseline data) demonstrated that the system can locate where the waves were reflected from the defect boundary. In other words, the contour of the damaged area was

  6. Structural Health Monitoring Using Lamb Wave Reflections and Total Focusing Method for Image Reconstruction

    Science.gov (United States)

    Muller, Aurelia; Robertson-Welsh, Bradley; Gaydecki, Patrick; Gresil, Matthieu; Soutis, Constantinos

    2016-11-01

    This investigation aimed to adapt the total focusing method (TFM) algorithm (originated from the synthetic aperture focusing technique in digital signal processing) to accommodate a circular array of piezoelectric sensors (PZT) and characterise defects using guided wave signals for the development of a structural health monitoring system. This research presents the initial results of a broader study focusing on the development of a structural health monitoring (SHM) guided wave system for advance carbon fibre reinforced plastic (CFRP) composite materials. The current material investigated was an isotropic (aluminium) square plate with 16 transducers operating successively as emitter or sensor in pitch and catch configuration enabling the collection of 240 signals per assessment. The Lamb wave signals collected were tuned on the symmetric fundamental mode with a wavelength of 17 mm, by setting the excitation frequency to 300 kHz. The initial condition for the imaging system, such as wave speed and transducer position, were determined with post processing of the baseline signals through a method involving the identification of the waves reflected from the free edge of the plate. The imaging algorithm was adapted to accommodate multiple transmitting transducers in random positions. A circular defect of 10 mm in diameter was drilled in the plate, which is similar to the delamination size introduced by a low velocity impact event in a composite plate. Images were obtained by applying the TFM to the baseline signals, Test 1 data (corresponding to the signals obtained after introduction of the defect) and to the data derived from the subtraction of the baseline to the Test 1 signals. The result shows that despite the damage diameter being 40 % smaller than the wavelength, the image (of the subtracted baseline data) demonstrated that the system can locate where the waves were reflected from the defect boundary. In other words, the contour of the damaged area was

  7. Using passive cavitation images to classify high-intensity focused ultrasound lesions.

    Science.gov (United States)

    Haworth, Kevin J; Salgaonkar, Vasant A; Corregan, Nicholas M; Holland, Christy K; Mast, T Douglas

    2015-09-01

    Passive cavitation imaging provides spatially resolved monitoring of cavitation emissions. However, the diffraction limit of a linear imaging array results in relatively poor range resolution. Poor range resolution has limited prior analyses of the spatial specificity and sensitivity of passive cavitation imaging in predicting thermal lesion formation. In this study, this limitation is overcome by orienting a linear array orthogonal to the high-intensity focused ultrasound propagation direction and performing passive imaging. Fourteen lesions were formed in ex vivo bovine liver samples as a result of 1.1-MHz continuous-wave ultrasound exposure. The lesions were classified as focal, "tadpole" or pre-focal based on their shape and location. Passive cavitation images were beamformed from emissions at the fundamental, harmonic, ultraharmonic and inharmonic frequencies with an established algorithm. Using the area under a receiver operating characteristic curve (AUROC), fundamental, harmonic and ultraharmonic emissions were found to be significant predictors of lesion formation for all lesion types. For both harmonic and ultraharmonic emissions, pre-focal lesions were classified most successfully (AUROC values of 0.87 and 0.88, respectively), followed by tadpole lesions (AUROC values of 0.77 and 0.64, respectively) and focal lesions (AUROC values of 0.65 and 0.60, respectively).

  8. A novel image-guided high-intensity focused ultrasound system for tumor treatment

    Science.gov (United States)

    Wu, Zhiqiang; Wu, Puwei; Chen, Bojie; Guan, Jian; Huang, Zheng

    2004-07-01

    A novel ultrasonography-guided high intensity focused ultrasound (HIFU) system (FS-100; Force Electronics Co. Ltd, Chongqing, China) was developed for non-invasive thermal ablation of tumor. The proprietary therapy delivery system is an integration of the digital image progressing, automatic control and the high intensity focused ultrasound thermal ablation devices. The therapeutic ultrasound probe (φ = 240 mm) consists of eight circular HIFU transducers with a curved surface of a diameter of 60 mm. Dual focused beams generated from the probe were used in this system for thermal delivery. The probe has the maximal resonance frequency of 1 MHz, a maximal treatment depth of 160 mm and focal spot diameter of 3 mm. The maximal intensity at the focal spot is 10,000 W/cm2. The imaging and HIFU components are located on top of the device, therefore, the focused ultrasound beams can be delivered to the patient in a supine position. The motion, targeting and localization of the probe are controlled by a PMAC-PC motion controller and an 8-independent-axis mechanical device. The linear motion error of the probe localization is <= 0.1 mm. The ultrasonographic image information is used for treatment planning and therapeutic interventions, such as target definition and registration, visualization of the three-dimensional anatomy of desired target(s), automatic positioning the thermal beams on targets, controlling thermal delivery, and rapid evaluation of target response post-treatment. The preclinical experimental results will be presented. The safety, feasibility and effectiveness of this novel HIFU system will be tested.

  9. Computational Complexity Reduction of Synthetic-aperture Focus in Ultrasound Imaging Using Frequency-domain Reconstruction.

    Science.gov (United States)

    Moghimirad, Elahe; Mahloojifar, Ali; Mohammadzadeh Asl, Babak

    2016-05-01

    A new frequency-domain implementation of a synthetic aperture focusing technique is presented in the paper. The concept is based on synthetic aperture radar (SAR) and sonar that is a developed version of the convolution model in the frequency domain. Compared with conventional line-by-line imaging, synthetic aperture imaging has a better resolution and contrast at the cost of more computational load. To overcome this problem, point-by-point reconstruction methods have been replaced by block-processing algorithms in radar and sonar; however, these techniques are relatively unknown in medical imaging. In this paper, we extended one of these methods called wavenumber to medical ultrasound imaging using a simple model of synthetic aperture focus. The model, derived here for monostatic mode, can be generalized to multistatic as well. The method consists of 4 steps: a 2D fast Fourier transform of the data, frequency shift of the data to baseband, interpolation to convert polar coordinates to rectangular ones, and returning the data to the spatial-domain using a 2D inverse Fourier transform. We have also used chirp pulse excitation followed by matched filtering and spotlighting algorithm to compensate the effect of differences in parameters between radar and medical imaging. Computational complexities of the two methods, wavenumber and delay-and-sum (DAS), have been calculated. Field II simulated point data have been used to evaluate the results in terms of resolution and contrast. Evaluations with simulated data show that for typical phantoms, reconstruction by the wavenumber algorithm is almost 20 times faster than classical DAS while retaining the resolution. © The Author(s) 2015.

  10. ENHANCING CLOSE-UP IMAGE BASED 3D DIGITISATION WITH FOCUS STACKING

    Directory of Open Access Journals (Sweden)

    G. Kontogianni

    2017-08-01

    Full Text Available The 3D digitisation of small artefacts is a very complicated procedure because of their complex morphological feature structures, concavities, rich decorations, high frequency of colour changes in texture, increased accuracy requirements etc. Image-based methods present a low cost, fast and effective alternative because laser scanning does not meet the accuracy requirements in general. A shallow Depth of Field (DoF affects the image-based 3D reconstruction and especially the point matching procedure. This is visible not only in the total number of corresponding points but also in the resolution of the produced 3D model. The extension of the DoF is a very important task that should be incorporated in the data collection to attain a better quality of the image set and a better 3D model. An extension of the DoF can be achieved with many methods and especially with the use of the focus stacking technique. In this paper, the focus stacking technique was tested in a real-world experiment to digitise a museum artefact in 3D. The experiment conditions include the use of a full frame camera equipped with a normal lens (50mm, with the camera being placed close to the object. The artefact has already been digitised with a structured light system and that model served as the reference model in which 3D models were compared and the results were presented.

  11. Flux distribution of solar furnace using non-imaging focusing heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Chern Sing [Department of Astronomy and Applied Physics, University of Science and Technology of China, Jinzhai Road, Hefei 230026 (China); Li, Li [Joint Advanced Research Center in Suzhou between University of Science and Technology of China and City University of Hong Kong, Dushu Lake Higher Education Town, Suzhou 215123 (China); Suzhou Institute for Advanced Study, University of Science and Technology of China, Dushu Lake Higher Education Town, Suzhou 215123 (China)

    2009-08-15

    This paper discusses on the flux distribution of a quasi-single stage solar furnace which consists of a non-imaging focusing heliostat as the primary stage and a much smaller spherical concentrator as a secondary. As the optics of the primary stage heliostat is of non-imaging nature, the analytical method for studying the flux distribution of the hot spot of this type of solar furnace would be complicated. Therefore, a digital simulation approach has been employed. Flux distributions of the hot spot for several different incident angles, which have covered all the extreme cases of operating conditions have been simulated. Simulation result shows that a solar furnace using an 8 x 8 m non-imaging focusing heliostat with 289 mirrors coupled with a spherical concentrator with 0.7 m aperture and 27 cm focal length is theoretically capable of achieving flux concentration of 25,000 suns. Concentration contours of flux distribution for several interesting cases are presented, the different working areas of high flux footage from 5000 to 15,000 suns have been compiled. (author)

  12. Full matrix capture and the total focusing imaging algorithm using laser induced ultrasonic phased arrays

    Science.gov (United States)

    Stratoudaki, Theodosia; Clark, Matt; Wilcox, Paul D.

    2017-02-01

    Laser ultrasonics is a technique where lasers are used for the generation and detection of ultrasound instead of conventional piezoelectric transducers. The technique is broadband, non-contact, and couplant free, suitable for large stand-off distances, inspection of components of complex geometries and hazardous environments. In this paper, array imaging is presented by obtaining the full matrix of all possible laser generation, laser detection combinations in the array (Full Matrix Capture), at the nondestructive, thermoelastic regime. An advanced imaging technique developed for conventional ultrasonic transducers, the Total Focusing Method (TFM), is adapted for laser ultrasonics and then applied to the captured data, focusing at each point of the reconstruction area. In this way, the beamforming and steering of the ultrasound is done during the post processing. A 1-D laser induced ultrasonic phased array is synthesized with significantly improved spatial resolution and defect detectability. In this study, shear waves are used for the imaging, since they are more efficiently produced than longitudinal waves in the nondestructive, thermoelastic regime. Experimental results are presented from nondestructive, laser ultrasonic inspection of aluminum samples with side drilled holes and slots at depths varying between 5 and 20mm from the surface.

  13. Second flight of the Focusing Optics X-ray Solar Imager sounding rocket [FOXSI-2

    Science.gov (United States)

    Buitrago-Casas, J. C.; Krucker, S.; Christe, S.; Glesener, L.; Ishikawa, S. N.; Ramsey, B.; Foster, N. D.

    2015-12-01

    The Focusing Optics X-ray Solar Imager (FOXSI) is a sounding rocket experiment that has flown twice to test a direct focusing method for measuring solar hard X-rays (HXRs). These HXRs are associated with particle acceleration mechanisms at work in powering solar flares and aid us in investigating the role of nanoflares in heating the solar corona. FOXSI-1 successfully flew for the first time on November 2, 2012. After some upgrades including the addition of extra mirrors to two optics modules and the inclusion of new fine-pitch CdTe strip detectors, in addition to the Si detectors from FOXSI-1, the FOXSI-2 payload flew successfully again on December 11, 2014. During the second flight four targets on the Sun were observed, including at least three active regions, two microflares, and ~1 minute of quiet Sun observation. This work is focused in giving an overview of the FOXSI rocket program and a detailed description of the upgrades for the second flight. In addition, we show images and spectra investigating the presence of no thermal emission for each of the flaring targets that we observed during the second flight.

  14. Development of profession and quality in radiography with focus on evaluation criteria and image quality of chest x-rays

    DEFF Research Database (Denmark)

    Debess, Jeanne; Thomsen, Henrik; Conradsen, Jacob

    2011-01-01

    Learning Objectives: Learning Objectives: To improve quality of chest xrays by Education Conferences for radiographers and evaluation of image quality. Background: Introduction of digital imaging technology and picture archiving and communication system (PACS) has changed the workflow in the x......-ray department including evaluation of image quality and feedback from radiologist to radiographer. Imaging Findings or Procedure Details: Procedure Details: Data for evaluation of image quality was collected by questionnaires aimed at: anatomy, image-focusing, image-collimation, exposure and body habitus...... collection were found. Evaluation results from anatomy, image-focusing, image-collimation and exposure from first data collection shows variations from 7 % to 37 % between evaluation at primary monitor by the radiographers and diagnostic monitor by the radiologist. In relation to anatomy, the quality...

  15. The First Focused Hard X-Ray Images of the Sun With NuSTAR

    DEFF Research Database (Denmark)

    Grefenstette, Brian W.; Glesener, Lindsay; Krucker, Sam

    2016-01-01

    We present results from the the first campaign of dedicated solar observations undertaken by the Nuclear Spectroscopic Telescope ARray (NuSTAR) hard X-ray (HXR) telescope. Designed as an astrophysics mission, NuSTAR nonetheless has the capability of directly imaging the Sun at HXR energies (>3 ke......V) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where NuSTAR will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with NuSTAR, their limitations......, and full-disk HXR images of the Sun....

  16. Enhancement of the total focusing method imaging for immersion testing of anisotropic carbon fiber composite structures

    Science.gov (United States)

    Aschy, Ameni; Terrien, Nicolas; Robert, Sébastien; Bentahar, Mourad

    2017-02-01

    The use of composite structures has importantly increased because of their reduced weight, assembly simplification and excellent specific strength and stiffness. The multiple possibilities of their manufacturing allow today to integrate within a single structure multiple functions: design, mechanical strength, multi-material…These structures, by their geometric and structural complexity (anisotropy, attenuation and scattering noise), do not always allow the application of conventional ultrasound real-time methods. In this communication, the problem related to anisotropy is treated in a first part with an analysis of the influence of materials properties on the conventional array imaging methods. In the second part, anisotropy is taken into account in the Total Focusing Method (TFM) to improve the image quality in carbon fiber composite plates.

  17. JPEG color barcode images analysis: A camera phone capture channel model with auto-focus

    Directory of Open Access Journals (Sweden)

    Keng T. Tan

    2009-12-01

    Full Text Available As camera phones have permeated into our everyday lives, two dimensional (2D barcode has attracted researchers and developers as a cost-effective ubiquitous computing tool. A variety of 2D barcodes and their applications have been developed. Often, only monochrome2D barcodes are used due to their robustness in an uncontrolled operating environment of camera phones. However, we are seeing an emerging use of color 2D barcodes for camera phones. Nonetheless, using a greater multitude of colors introduces errors that can negatively affect the robustness of barcode reading. This is especially true when developing a 2D barcode for camera phones which capture and store these barcode images in the baselineJPEG format. This paper presents one aspect of the errors introduced by such camera phones by modeling the camera phone capture channel for JPEG color barcode images wherein there is camera auto-focus.

  18. The First Focused Hard X-Ray Images of the Sun With NuSTAR

    DEFF Research Database (Denmark)

    Grefenstette, Brian W.; Glesener, Lindsay; Krucker, Sam

    2016-01-01

    We present results from the the first campaign of dedicated solar observations undertaken by the Nuclear Spectroscopic Telescope ARray (NuSTAR) hard X-ray (HXR) telescope. Designed as an astrophysics mission, NuSTAR nonetheless has the capability of directly imaging the Sun at HXR energies (>3 ke......V) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where NuSTAR will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with NuSTAR, their limitations......, and full-disk HXR images of the Sun....

  19. High-throughput imaging: Focusing in on drug discovery in 3D.

    Science.gov (United States)

    Li, Linfeng; Zhou, Qiong; Voss, Ty C; Quick, Kevin L; LaBarbera, Daniel V

    2016-03-01

    3D organotypic culture models such as organoids and multicellular tumor spheroids (MCTS) are becoming more widely used for drug discovery and toxicology screening. As a result, 3D culture technologies adapted for high-throughput screening formats are prevalent. While a multitude of assays have been reported and validated for high-throughput imaging (HTI) and high-content screening (HCS) for novel drug discovery and toxicology, limited HTI/HCS with large compound libraries have been reported. Nonetheless, 3D HTI instrumentation technology is advancing and this technology is now on the verge of allowing for 3D HCS of thousands of samples. This review focuses on the state-of-the-art high-throughput imaging systems, including hardware and software, and recent literature examples of 3D organotypic culture models employing this technology for drug discovery and toxicology screening.

  20. Nanosecond-gating properties of proximity-focused microchannel-plate image intensifiers

    Science.gov (United States)

    King, N. S. P.; Yates, G. J.; Jaramillo, S. A.; Ogle, J. W.

    Some fundamental properties of 18 mm-diam gated proximity focussed microchannel plate (MCP) image intensifiers used as fast image shutters in the 1 to 10 ns range were identified and studied. Light pulses from a modelocked dye laser optically sample the gated MCP. Shuttering is achieved by applying a forward biasing electrical gate pulse to the quiescently reverse-biased photocathode MCP interface. Variable delay between the gate pulse and the laser pulse permits tracing the MCP's optical response. Gating speeds, turn-on and turn-off patterns, the asymmetric spatial depedence of the MCP optical response, and resolution effects as functions of gate pulse width and photocathode-MCP bias were characterized. Variations in the intensity profiles of the phosphor's spatial response for uniform photocathode illumination are measured with a calibrated silicon intensified target focus projection, scan television camera and a high speed video digitizer while photomultipliers monitor the laser pulse and the phosphor's spatially integrated output intensities.

  1. Imaging in repaired tetralogy of Fallot with a focus on recent advances in echocardiography.

    Science.gov (United States)

    Larios, Guillermo; Friedberg, Mark K

    2017-09-01

    Imaging is essential for the management of adults with repaired tetralogy of Fallot (rToF). Echocardiography and cardiac magnetic resonance imaging are the central modalities to assess rToF. Here we review recent literature on imaging rToF, focusing on echocardiography and advances in assessment of cardiac mechanics. Several two-dimensional, three-dimensional, and Doppler echo parameters have been proposed to assess pulmonary regurgitation, right ventricular volumes and ejection fraction, but most of them still have important limitations in their feasibility and reliability compared to cardiac magnetic resonance (CMR). Myocardial deformation imaging to study ventricular and atrial mechanics, regional function, ventricular-ventricular interactions, and electro-mechanical dyssynchrony has yielded insights into the pathophysiologic mechanisms of right ventricular and left ventricular dysfunction; thereby predicting clinical outcomes and exercise capacity, allowing among others, evaluation of the impact of pulmonary valve replacement (PVR). Emerging technologies are expected to further our understanding of the drivers of dysfunction and guide indications and timing of PVR. Echocardiography and CMR have complementary and overlapping roles in rToF and contribute to our understanding of its pathophysiology and management.

  2. Diffusion tensor imaging in inflammatory and neoplastic intramedullary spinal cord lesions: Focusing on fiber tracking

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo Jin; Lee, Joon Woo; Lee, Eugene; Kim, Sung Gon; Kang, Yu Suhn; Ahn, Joong Mo; Kang, Heung Sik [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2017-02-15

    Inflammatory and neoplastic intramedullary spinal cord lesions have overlapping clinical features, and it is occasionally difficult to distinguish one from the other on conventional magnetic resonance imaging. We aimed to compare diffusion tensor imaging findings between inflammatory and neoplastic intramedullary spinal cord lesions, with a specific focus on patterns of fiber tracking. Diffusion tensor imaging was performed in patients with either inflammatory or neoplastic intramedullary spinal cord lesions. The fiber tracking patterns (categorized as “intact,” “displaced,” or “interrupted”) were compared between these two groups. Eight patients were included in the study: 5 patients with pathologically or clinically confirmed inflammatory lesions and 3 patients with pathologically or clinically confirmed neoplastic lesions. Among the 5 patients with inflammatory lesions, 2 patients exhibited the displaced pattern and 3 patients exhibited the intact pattern. Among the 3 patients with neoplastic lesions, 1 patient exhibited the intact pattern, 1 patient exhibited the displaced pattern, and 1 patient exhibited the interrupted pattern. In this study, inflammatory and neoplastic intramedullary spinal cord lesions were not clearly differentiated by fiber tracking; both conditions can present with overlapping features such as displaced fibers. The exclusion of inflammatory conditions based on the presence of displaced fibers in fiber tracking images should be avoided.

  3. Ultrasound imaging and evaluation of lesion induced by High Intensity Focused Ultrasound

    Institute of Scientific and Technical Information of China (English)

    ZHONG Hui; WAN Mingxi; JIANG Yifeng; WANG Supin

    2006-01-01

    The present study was to investigate the differential imaging method for detecting HIFU (High Intensity Focused Ultrasound)-induced lesions and the estimation of variation of attenuation for lesion evaluation with log spectral difference algorithm. Experiment results of bovine muscle and liver in vitro were acquired. Several algorithms for lesion detection - Absolute Difference (AD), Sum Absolute Differences (SAD) and Sum Squared Differences (SSD) - were analyzed with several window sizes and threshold values. Then three attenuation parameters were compared to evaluate the degree of tissue damage. It was found that variation of the mean attenuation △(α) was an effective parameter to evaluate lesions.

  4. Fast extended focused imaging in digital holography using a graphics processing unit.

    Science.gov (United States)

    Wang, Le; Zhao, Jianlin; Di, Jianglei; Jiang, Hongzhen

    2011-05-01

    We present a simple and effective method for reconstructing extended focused images in digital holography using a graphics processing unit (GPU). The Fresnel transform method is simplified by an algorithm named fast Fourier transform pruning with frequency shift. Then the pixel size consistency problem is solved by coordinate transformation and combining the subpixel resampling and the fast Fourier transform pruning with frequency shift. With the assistance of the GPU, we implemented an improved parallel version of this method, which obtained about a 300-500-fold speedup compared with central processing unit codes.

  5. First Images from HERO: A Hard-X-Ray Focusing Telescope

    Science.gov (United States)

    Ramsey, Brian D.; Alexander, Cheryl D.; Apple, Jeff A.; Benson, Carl M.; Dietz, Kurtis L.; Elsner, Ronald F.; Engelhaupt, Darell E.; Ghosh, Kajal K.; Kolodziejczak, Jeffery J.; ODell, Stephen L.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    We are developing a balloon-borne hard-x-ray telescope that utilizes grazing incidence optics. Termed HERO, for High-Energy Replicated Optics, the instrument will provide unprecented sensitivity in the hard-x-ray region and will achieve milliCrab-level sensitivity in a typical 3-hour balloon-flight observation and 50 microCrab sensitivity on ultra-long-duration flights. A recent proof-of-concept flight, featuring a small number of mirror shells captured the first focused hard-x-ray images of galactic x-ray sources. Full details of the payload, its expected future performance and its recent measurements are provided.

  6. OUT-OF-FOCUS REGION SEGMENTATION OF 2D SURFACE IMAGES WITH THE USE OF TEXTURE FEATURES

    Directory of Open Access Journals (Sweden)

    K. Anding

    2015-09-01

    Full Text Available A segmentation method of out-of-focus image regions for processed metal surfaces, based on focus textural features is proposed. Such regions contain small amount of useful information. The object of study is a metal surface, which has a cone shape. Some regions of images are blurred because the depth of field of industrial cameras is limited. Automatic removal of out-of-focus regions in such images is one of the possible solutions to this problem. Focus texture features were used to calculate characteristics that describe the sharpness of particular image area. Such features are used in autofocus systems of microscopes and cameras, and their application for segmentation of out-of-focus regions of images is unusual. Thirty-four textural features were tested on a set of metal surface images with out-of-focus regions. The most useful features, usable for segmentation of an image more accurately, are an average grey level and spatial frequency. Proposed segmentation method of out-of-focus image regions for metal surfaces can be successfully applied for evaluation of processing quality of materials with the use of industrial cameras. The method has simple implementation and high calculating speed.

  7. Focusing and imaging properties of diffractive optical elements with star-ring topological structure

    Science.gov (United States)

    Ke, Jie; Zhang, Junyong; Zhang, Yanli; Sun, Meizhi

    2015-08-01

    A kind of diffractive optical elements (DOE) with star-ring topological structure is proposed and their focusing and imaging properties are studied in detail. The so-called star-ring topological structure denotes that a large number of pinholes distributed in many specific zone orbits. In two dimensional plane, this structure can be constructed by two constrains, one is a mapping function, which yields total potential zone orbits, corresponding to the optical path difference (OPD); the other is a switching sequence based on the given encoded seed elements and recursion relation to operate the valid zone orbits. The focusing and imaging properties of DOE with star-ring topological structure are only determined by the aperiodic sequence, and not relevant to the concrete geometry structure. In this way, we can not only complete the traditional symmetrical DOE, such as circular Dammam grating, Fresnel zone plates, photon sieves, and their derivatives, but also construct asymmetrical elements with anisotropic diffraction pattern. Similarly, free-form surface or three dimensional DOE with star-ring topological structure can be constructed by the same method proposed. In consequence of smaller size, lighter weight, more flexible design, these elements may allow for some new applications in micro and nanphotonics.

  8. Focused shape models for hip joint segmentation in 3D magnetic resonance images.

    Science.gov (United States)

    Chandra, Shekhar S; Xia, Ying; Engstrom, Craig; Crozier, Stuart; Schwarz, Raphael; Fripp, Jurgen

    2014-04-01

    Deformable models incorporating shape priors have proved to be a successful approach in segmenting anatomical regions and specific structures in medical images. This paper introduces weighted shape priors for deformable models in the context of 3D magnetic resonance (MR) image segmentation of the bony elements of the human hip joint. The fully automated approach allows the focusing of the shape model energy to a priori selected anatomical structures or regions of clinical interest by preferentially ordering the shape representation (or eigen-modes) within this type of model to the highly weighted areas. This focused shape model improves accuracy of the shape constraints in those regions compared to standard approaches. The proposed method achieved femoral head and acetabular bone segmentation mean absolute surface distance errors of 0.55±0.18mm and 0.75±0.20mm respectively in 35 3D unilateral MR datasets from 25 subjects acquired at 3T with different limited field of views for individual bony components of the hip joint.

  9. Extended depth of focus tethered capsule OCT endomicroscopy for upper gastrointestinal tract imaging (Conference Presentation)

    Science.gov (United States)

    Vuong, Barry; Yin, Biwei; Beaulieu-Ouellet, Emilie; Liang, Chia Pin; Beatty, Matthew; Singh, Kanwarpal; Dong, Jing; Grant, Catriona N.; Rosenberg, Mireille; Tearney, Guillermo J.

    2017-02-01

    Endoscopy, the current standard of care for the diagnosis of upper gastrointestinal (GI) diseases, is not ideal as a screening tool because it is costly, necessitates a team of medically trained personnel, and typically requires that the patient be sedated. Endoscopy is also a superficial macroscopic imaging modality and therefore is unable to provide detailed information on subsurface microscopic structure that is required to render a precise tissue diagnosis. We have overcome these limitations through the development of an optical coherence tomography tethered capsule endomicroscopy (OCT-TCE) imaging device. The OCT-TCE device has a pill-like form factor with an optically clear wall to allow the contained opto-mechanical components to scan the OCT beam along the circumference of the esophagus. Once swallowed, the OCT-TCE device traverses the esophagus naturally via peristalsis and multiple cross-sectional OCT images are obtained at 30-40 μm lateral resolution by 7 μm axial resolution. While this spatial resolution enables differentiation of squamous vs columnar mucosa, crucial microstructural features such as goblet cells ( 10 μm), which signify intestinal metaplasia in BE, and enlarged nuclei that are indicative of dysplasia cannot be resolved with the current OCT-TCE technology. In this work we demonstrate a novel design of a high lateral resolution OCT-TCE device with an extended depth of focus (EDOF). The EDOF is created by use of self-imaging wavefront division multiplexing that produces multiple focused modes at different depths into the sample. The overall size of the EDOF TCE is similar to that of the previous OCT-TCE device ( 11 mm by 26 mm) but with a lateral resolution of 8 μm over a depth range of 2 mm. Preliminary esophageal and intestinal imaging using these EDOF optics demonstrates an improvement in the ability to resolve tissue morphology including individual glands and cells. These results suggest that the use of EDOF optics may be a

  10. Single-element focused ultrasound transducer method for harmonic motion imaging.

    Science.gov (United States)

    Maleke, Caroline; Pernot, Mathieu; Konofagou, Elisa E

    2006-07-01

    The harmonic motion imaging (HMI) technique for simultaneous monitoring and generation of ultrasound therapy using two separate focused ultrasound transducer elements was previously demonstrated. In this study, a new HMI technique is described that images tissue displacement induced by a harmonic radiation force using a single focused-ultrasound element. A wave propagation simulation model first indicated that, unlike in the two-beam configuration, the amplitude-modulated beam produced a stable focal zone for the applied harmonic radiation force. The AM beam thus offered the unique advantage of sustaining the application of the spatially-invariant radiation force. Experiments were performed on gelatin phantoms and ex vivo tissues. The radiation force was generated by a 4.68 MHz focused ultrasound (FUS) transducer using a 50 Hz amplitude-modulated wave. A 7.5 MHz pulse-echo transducer was used to acquire rf echoes during the application of the harmonic radiation force. Consecutive rf echoes were acquired with a pulse repetition frequency (PRF) of 6.5 kHz and 1D cross-correlation was performed to estimate the resulting axial tissue displacement. The HMI technique was shown capable of estimating stiffness-dependent displacement amplitudes. Finally, taking advantage of the real-time capability of the HMI technique, temperature-dependent measurements enabled monitoring ofHIFU sonication in ex vivo tissues. The new HMI method may thus enable a highly-localized force and stiffness-dependent measurements as well as real-time and low-cost HIFU monitoring.

  11. A fast autofocus setup using a liquid lens objective for in-focus imaging in the macro range

    Science.gov (United States)

    Pasinetti, Simone; Bodini, Ileana; Sansoni, Giovanna; Docchio, Franco; Tinelli, Matteo; Lancini, Matteo

    2016-06-01

    A fast and reliable optical setup is here presented for in-focus imaging of objects in the macro range. The setup uses a camera equipped with an objective embedding a liquid lens, whose focal length is voltage-controlled. The defocus condition of the image is controlled by means of two indexes, both suitable for coarse and for fine adjustments. A purposely designed algorithm makes use of the two indexes, switching from one to the other to position the image in focus by adequately controlling the liquid lens focal length. The setup has been calibrated by means of target planes of known contrasts, and applied to process biomedical images such as fingerprints.

  12. Murine cardiac images obtained with focusing pinhole SPECT are barely influenced by extra-cardiac activity

    Science.gov (United States)

    Branderhorst, Woutjan; van der Have, Frans; Vastenhouw, Brendan; Viergever, Max A.; Beekman, Freek J.

    2012-02-01

    Ultra-high-resolution SPECT images can be obtained with focused multipinhole collimators. Here we investigate the influence of unwanted high tracer uptake outside the scan volume on reconstructed tracer distributions inside the scan volume, for 99mTc-tetrofosmin myocardial perfusion scanning in mice. Simulated projections of a digital mouse phantom (MOBY) in a focusing multipinhole SPECT system (U-SPECT-II, MILabs, The Netherlands) were generated. With this system differently sized user-defined scan volumes can be selected, by translating the animal in 3D through the focusing collimators. Scan volume selections were set to (i) a minimal volume containing just the heart, acquired without translating the animal during scanning, (ii) a slightly larger scan volume as is typically applied for the heart, requiring only small XYZ translations during scanning, (iii) same as (ii), but extended further transaxially, and (iv) same as (ii), but extended transaxially to cover the full thorax width (gold standard). Despite an overall negative bias that is significant for the minimal scan volume, all selected volumes resulted in visually similar images. Quantitative differences in the reconstructed myocardium between gold standard and the results from the smaller scan volume selections were small; the 17 standardized myocardial segments of a bull's eye plot, normalized to the myocardial mean of the gold standard, deviated on average 6.0%, 2.5% and 1.9% for respectively the minimal, the typical and the extended scan volume, while maximum absolute deviations were respectively 18.6%, 9.0% and 5.2%. Averaged over ten low-count noisy simulations, the mean absolute deviations were respectively 7.9%, 3.2% and 1.9%. In low-count noisy simulations, the mean and maximum absolute deviations for the minimal scan volume could be reduced to respectively 4.2% and 12.5% by performing a short survey scan of the exterior activity and focusing the remaining scan time at the organ of interest. We

  13. Improved highly accurate localized motion imaging for monitoring high-intensity focused ultrasound therapy

    Science.gov (United States)

    Qu, Xiaolei; Azuma, Takashi; Sugiyama, Ryusuke; Kanazawa, Kengo; Seki, Mika; Sasaki, Akira; Takeuchi, Hideki; Fujiwara, Keisuke; Itani, Kazunori; Tamano, Satoshi; Takagi, Shu; Sakuma, Ichiro; Matsumoto, Yoichiro

    2016-07-01

    Visualizing an area subjected to high-intensity focused ultrasound (HIFU) therapy is necessary for controlling the amount of HIFU exposure. One of the promising monitoring methods is localized motion imaging (LMI), which estimates coagulation length by detecting the change in stiffness. In this study, we improved the accuracy of our previous LMI by dynamic cross-correlation window (DCCW) and maximum vibration amount (MVA) methods. The DCCW method was used to increase the accuracy of estimating vibration amplitude, and the MVA method was employed to increase signal-noise ratio of the decrease ratio at the coagulated area. The qualitative comparison of results indicated that the two proposed methods could suppress the effect of noise. Regarding the results of the quantitative comparison, coagulation length was estimated with higher accuracy by the improved LMI method, and the root-mean-square error (RMSE) was reduced from 2.51 to 1.69 mm.

  14. Real-time feedback control for high-intensity focused ultrasound system using localized motion imaging

    Science.gov (United States)

    Sugiyama, Ryusuke; Kanazawa, Kengo; Seki, Mika; Azuma, Takashi; Sasaki, Akira; Takeuchi, Hideki; Fujiwara, Keisuke; Itani, Kazunori; Tamano, Satoshi; Yoshinaka, Kiyoshi; Takagi, Shu; Matsumoto, Yoichiro

    2015-07-01

    High-intensity focused ultrasound (HIFU) is one of the noninvasive treatment for tumors. Visualizing the treated area inside the human body is necessary to control the HIFU exposure. Localized motion imaging (LMI) using ultrasound to induce and detect tissue deformation is one technique to detect a change in tissue stiffness caused by thermal coagulation. In experiments with porcine liver, LMI has shown to detect deformation with less than 20% accuracy. We have developed a prototype feedback control system using real-time LMI. In this system, coagulation size was measured every 1 s and controlled to correspond to a targeted size. The typical size error was reduced to 14% from 35%. LMI displacements in normal and coagulated tissues were sufficiently different to discriminate between coagulated areas and noncoagulated ones after HIFU sonication and to visualize treated areas after HIFU treatment.

  15. [Analysis of images in Japanese book Fukusho-Kiran (Medical Book Focusing on Abdominal Palpation) and Fukusho-Kiran yoku (Supplement to Medical Book Focusing on Abdominal Palpation)].

    Science.gov (United States)

    Zhang, Lijun; DI, Kan; Song, Yuanliang

    2014-09-01

    Hukusyo-kiran (Medical Book Focusing on Abdominal Palpation) and Hukusyo-kiran yoku (Supplement to Medical Book Focusing on Abdominal Palpation) are two typical monographs of Fukushin (abdominal palpation), with a total of 148 images about abdominal palpation. These images can be divided into 5 kinds: locations, theories, techniques, diseases and medicines, with its own system covering the theories, principles, prescriptions and medicines of abdominal palpation. It can be used as a guide for clinicians to differentiate the locations and qualities of diseases, confirm the principles of treatment, guide the usage of medicines, and predict the prognosis, with the rather high theoretic and academic value, deserving further research and analysis for the modern scholars.

  16. Quantitative ultrasound imaging for monitoring in situ high-intensity focused ultrasound exposure.

    Science.gov (United States)

    Ghoshal, Goutam; Kemmerer, Jeremy P; Karunakaran, Chandra; Abuhabsah, Rami; Miller, Rita J; Sarwate, Sandhya; Oelze, Michael L

    2014-10-01

    Quantitative ultrasound (QUS) imaging is hypothesized to map temperature elevations induced in tissue with high spatial and temporal resolution. To test this hypothesis, QUS techniques were examined to monitor high-intensity focused ultrasound (HIFU) exposure of tissue. In situ experiments were conducted on mammary adenocarcinoma tumors grown in rats and lesions were formed using a HIFU system. A thermocouple was inserted into the tumor to provide estimates of temperature at one location. Backscattered time-domain waveforms from the tissue during exposure were recorded using a clinical ultrasonic imaging system. Backscatter coefficients were estimated using a reference phantom technique. Two parameters were estimated from the backscatter coefficient (effective scatterer diameter (ESD) and effective acoustic concentration (EAC). The changes in the average parameters in the regions corresponding to the HIFU focus over time were correlated to the temperature readings from the thermocouple. The changes in the EAC parameter were consistently correlated to temperature during both heating and cooling of the tumors. The changes in the ESD did not have a consistent trend with temperature. The mean ESD and EAC before exposure were 120 ± 16 μm and 32 ± 3 dB/cm3, respectively, and changed to 144 ± 9 μm and 51 ± 7 dB/cm3, respectively, just before the last HIFU pulse was delivered to the tissue. After the tissue cooled down to 37 °C, the mean ESD and EAC were 126 ± 8 μm and 35 ± 4 dB/cm3, respectively. Peak temperature in the range of 50-60 °C was recorded by a thermocouple placed just behind the tumor. These results suggest that QUS techniques have the potential to be used for non-invasive monitoring of HIFU exposure.

  17. Measurement of temperature decrease caused by blood flow in focused ultrasound irradiation by thermal imaging method

    Science.gov (United States)

    Tsuchiya, Takenobu; Hatano, Yuichi; Mori, Yashunori; Shen, Rakushin; Endoh, Nobuyuki

    2016-07-01

    In this study, to estimate the local temperature changes caused by a thick blood vessel, the temperature distribution in a tissue phantom with a thick blood vessel during focused ultrasound irradiation was measured by a thermal imaging method. The blood flow rate in the simulated blood vessel was varied and the relationship between flow rate and temperature decrease was examined. The phantom using the thermal imaging method is divided into two parts, and the increases in temperature distribution as a function of blood flow rate are measured using a thermocamera under constant ultrasound irradiation. The irradiation conditions of ultrasound waves were a central frequency of 1 MHz, a wave number length of 200 cycles, and a duty ratio of 0.2. The irradiation duration was 5 min, and the ultrasound intensity I SPTA was 36 W/cm2. The amount of temperature decrease caused by the cooling effect of blood flow increased with the blood flow rate and it became constant at a certain threshold of blood flow rate. The threshold of blood flow rate is about 250 ml/min.

  18. Magnetic resonance imaging of boiling induced by high intensity focused ultrasound.

    Science.gov (United States)

    Khokhlova, Tatiana D; Canney, Michael S; Lee, Donghoon; Marro, Kenneth I; Crum, Lawrence A; Khokhlova, Vera A; Bailey, Michael R

    2009-04-01

    Both mechanically induced acoustic cavitation and thermally induced boiling can occur during high intensity focused ultrasound (HIFU) medical therapy. The goal was to monitor the temperature as boiling was approached using magnetic resonance imaging (MRI). Tissue phantoms were heated for 20 s in a 4.7-T magnet using a 2-MHz HIFU source with an aperture and radius of curvature of 44 mm. The peak focal pressure was 27.5 MPa with corresponding beam width of 0.5 mm. The temperature measured in a single MRI voxel by water proton resonance frequency shift attained a maximum value of only 73 degrees C after 7 s of continuous HIFU exposure when boiling started. Boiling was detected by visual observation, by appearance on the MR images, and by a marked change in the HIFU source power. Nonlinear modeling of the acoustic field combined with a heat transfer equation predicted 100 degrees C after 7 s of exposure. Averaging of the calculated temperature field over the volume of the MRI voxel (0.3 x 0.5 x 2 mm(3)) yielded a maximum of 73 degrees C that agreed with the MR thermometry measurement. These results have implications for the use of MRI-determined temperature values to guide treatments with clinical HIFU systems.

  19. The First Focused Hard X-ray Images of the Sun with NuSTAR

    CERN Document Server

    Grefenstette, Brian W; Krucker, Säm; Hudson, Hugh; Hannah, Iain G; Smith, David M; Vogel, Julia K; White, Stephen M; Madsen, Kristin K; Marsh, Andrew J; Caspi, Amir; Chen, Bin; Shih, Albert; Kuhar, Matej; Boggs, Steven E; Christensen, Finn E; Craig, William W; Forster, Karl; Hailey, Charles J; Harrison, Fiona A; Miyasaka, Hiromasa; Stern, Daniel; Zhang, William W

    2016-01-01

    We present results from the the first campaign of dedicated solar observations undertaken by the \\textit{Nuclear Spectroscopic Telescope ARray} ({\\em NuSTAR}) hard X-ray telescope. Designed as an astrophysics mission, {\\em NuSTAR} nonetheless has the capability of directly imaging the Sun at hard X-ray energies ($>$3~keV) with an increase in sensitivity of at least two magnitude compared to current non-focusing telescopes. In this paper we describe the scientific areas where \\textit{NuSTAR} will make major improvements on existing solar measurements. We report on the techniques used to observe the Sun with \\textit{NuSTAR}, their limitations and complications, and the procedures developed to optimize solar data quality derived from our experience with the initial solar observations. These first observations are briefly described, including the measurement of the Fe K-shell lines in a decaying X-class flare, hard X-ray emission from high in the solar corona, and full-disk hard X-ray images of the Sun.

  20. Nanosecond Gating Properties Of Proximity-Focused Microchannel-Plate Image Intensifiers

    Science.gov (United States)

    King, N. S.; Yates, G. J.; Jaramillo, S. A.; Ogle, J. W.; Detch, J. L.

    1981-12-01

    Some fundamental properties of 18-mm-diam gated proximity-focussed microchannel-plate (MCP) image intensifiers used as fast image shutters in the 1 to 10 ns range have been identified and studied. Light pulses (≍ 5-ps-wide) from a modelocked dye laser optically sample the gated MCP. Shuttering is achieved by applying a forward-biasing electrical gate pulse to the quiescently reverse-biased photocathode-MCP interface. Variable delay (≍ 30-ps jitter) between the gate pulse and the laser pulse permit tracing the MCP's optical response. Gating speeds, turn-on and turn-off patterns, the asymmetric spatial dependence of the MCP optical response, and resolution effects as functions of gate pulse width and photocathode-MCP bias have been characterized. Shutter times of >= 750 ps and <= 5 1p/mm resolution with the MCP fully on were observed. Variations in the intensity profiles of the phosphorl.s spatial response for uniform photocathode illumination are measured with a calibrated silicon-intensified-target (SIT) focus projection, scan (FPS) television camera and a high-speed video digitizer while photomultipliers (PMTs) monitor the laser pulse and the phosphor's spatially integrated output intensities. The characterization system, gating and biasing circuits, and experimental results will be presented.

  1. Soft X-Ray Magnetic Imaging of Focused Ion Beam Lithographically Patterned Fe Thin Films

    Energy Technology Data Exchange (ETDEWEB)

    Cook, Paul J.; Shen, Tichan H.; Grundy, PhilJ.; Im, Mi Young; Fischer, Peter; Morton, Simon A.; Kilcoyne, Arthur D.L.

    2008-11-09

    We illustrate the potential of modifying the magnetic behavior and structural properties of ferromagnetic thin films using focused ion beam 'direct-write' lithography. Patterns inspired by the split-ring resonators often used as components in meta-materials were defined upon 15 nm Fe films using a 30 keV Ga{sup +} focused ion beam at a dose of 2 x 10{sup 16} ions cm{sup -2}. Structural, chemical and magnetic changes to the Fe were studied using transmission soft X-ray microscopy at the ALS, Berkeley CA. X-ray absorption spectra showed a 23% reduction in the thickness of the film in the Ga irradiated areas, but no change to the chemical environment of Fe was evident. X-ray images of the magnetic reversal process show domain wall pinning around the implanted areas, resulting in an overall increase in the coercivity of the film. Transmission electron microscopy showed significant grain growth in the implanted regions.

  2. Advanced imaging with dynamic focus and extended depth using integrated FR4 platform.

    Science.gov (United States)

    Isikman, Serhan O; Varghese, Samuel; Abdullah, Fahd; Augustine, Robin; Sprague, Randy B; Andron, Voytek; Urey, Hakan

    2009-09-14

    A two-degrees-of-freedom scanned beam imaging system with large dynamic range and dynamic focusing is demonstrated. The laser diode, photo-detector and the optical components are integrated on a moving platform that is made of FR4 (Flame-Retardant 4), a common polymeric substrate used in printed circuit boards. A scan angle of 52 degrees is demonstrated at 60 Hz resonant frequency while the laser is moved 250 um in the out-of-plane direction to achieve dynamic focusing. The laser is scanned by physically rotating the laser diode and the collection optics to achieve high signal-to-noise ratio and good ambient light rejection. The collection optics is engineered such that the collection efficiency decreases when collecting light from close distances to avoid detector saturation. The detection range is extended from contact distance up to 600 mm while the collected power level varies only by a factor of 30 within this long range. Slight modifications will allow increasing the detection range up to one meter. This is the first demonstration of a laser scan engine with such a high degree of integration of electronics, optoelectronics, optics and micromechanics on the same platform.

  3. Surgical imaging catheter for confocal microendoscopy with advanced contrast delivery and focus systems

    Science.gov (United States)

    Tanbakuchi, Anthony A.; Rouse, Andrew R.; Udovich, Josh A.; Gmitro, Arthur F.

    2006-02-01

    We present a laparoscope for fluorescence confocal microendoscopy specifically designed for microscopic imaging during diagnostic laparoscopic surgery. The catheter consists of a disposable rigid distal tip which houses a flexible microendoscope and dye channel. The laparoscopic tip is a small disposable polycarbonate sheath containing two inner lumens with a glass window on the distal end. The sheath outer diameter suitable for use in a 5mm trocar. The smaller inner lumen provides a channel for delivering fluorescent contrast agents to the tissue through a 200um hole in the glass window. On the proximal end, the smaller lumen is coupled to a computer controlled fluid delivery system that controls the amount of contrast agent dispensed onto the tissue down to a fraction of a micro liter. The main lumen houses the microendoscope. The microendoscope incorporates a computer-controlled focus mechanism that can quickly and accurately focus while correcting for hysteresis. This fluorescence confocal micro-laparoscope will be tested in a small-scale clinical trial on women undergoing oophorectomy in the near future.

  4. Does the Internet function like magazines? An exploration of image-focused media, eating pathology, and body dissatisfaction.

    Science.gov (United States)

    Bair, Carrie E; Kelly, Nichole R; Serdar, Kasey L; Mazzeo, Suzanne E

    2012-12-01

    Research has identified a relation between exposure to thin-ideal magazine and television media images and eating disorder pathology. However, few studies have examined the potential influence of Internet media on eating disorder behaviors and attitudes. This study investigated associations among image-focused media exposure, body dissatisfaction, eating pathology and thin-ideal internalization in a sample of 421 female undergraduates. Undergraduate women spent significantly more time viewing online appearance-oriented media, rather than reading image-focused magazines. Appearance-oriented Internet and television use were associated with eating pathology. Moreover, the association between image-focused Internet use and BD was mediated by thin-ideal internalization. These findings are consistent with those of previous research, and highlight the vulnerability individuals high in thin-ideal internalization might have to media exposure. They also suggest that Internet media use is an important topic to attend to in eating disorders prevention and treatment.

  5. Extended depth from focus reconstruction using NIH ImageJ plugins: quality and resolution of elevation maps.

    Science.gov (United States)

    Hein, Luis Rogerio De Oliveira; De Oliveira, José Alberto; De Campos, Kamila Amato; Caltabiano, Pietro Carelli Reis De Oliveira

    2012-11-01

    In this work, NIH ImageJ plugins for extended depth-from-focus reconstructions (EDFR) based on spatial domain operations were compared and tested for usage optimization. Also, some preprocessing solutions for light microscopy image stacks were evaluated, suggesting a general routine for the ImageJ user to get reliable elevation maps from grayscale image stacks. Two reflected light microscope image stacks were used to test the EDFR plugins: one bright-field image stack for the fracture of carbon-epoxy composite and its darkfield corresponding stack at same (x,y,z) spatial coordinates. Image quality analysis consisted of the comparison of signal-to-noise ratio and resolution parameters with the consistence of elevation maps, based on roughness and fractal measurements. Darkfield illumination contributed to enhance the homogeneity of images in stack and resulting height maps, reducing the influence of digital image processing choices on the dispersion of topographic measurements. The subtract background filter, as a preprocessing tool, contributed to produce sharper focused images. In general, the increasing of kernel size for EDFR spatial domain-based solutions will produce smooth height maps. Finally, this work has the main objective to establish suitable guidelines to generate elevation maps by light microscopy.

  6. Paraxial analysis of zoom lens composed of three tunable-focus elements with fixed position of image-space focal point and object-image distance.

    Science.gov (United States)

    Miks, Antonin; Novak, Jiri

    2014-11-03

    This work performs a paraxial analysis of three-component zoom lens with a fixed position of image-space focal point and a distance between object and image points, which is composed of three tunable-focus elements. Formulas for the calculation of paraxial parameters of such optical systems are derived and the calculation is presented on examples.

  7. Wide-field multiphoton imaging of cellular dynamics in thick tissue by temporal focusing and patterned illumination

    Science.gov (United States)

    Therrien, O. D.; Aubé, B.; Pagès, S.; Koninck, P. De; Côté, D.

    2011-01-01

    Wide-field temporal focusing is a novel technique that provides optical sectioning for imaging without the need for beam scanning. However, illuminating over large areas greatly reduces the photon density which limits the technique applicability to small regions, precluding functional imaging of cellular networks. Here we present a strategy that combines beam shaping and temporal focusing of amplified pulses (>1 µJ/pulse) for fast imaging of cells from the central nervous system in acute slices. Multiphoton video-rate imaging over total areas as wide as 4800 µm2 with an optical sectioning under 10 µm at 800 nm is achieved with our setup, leading to imaging of calcium dynamics of multiple cells simultaneously in thick tissue. PMID:21412473

  8. Three-dimensional interferometric inverse synthetic aperture radar imaging of maneuvering target based on the joint cross modified Wigner-Ville distribution

    Science.gov (United States)

    Lv, Qian; Su, Tao; Zheng, Jibin; Zhang, Jiancheng

    2016-01-01

    Inverse synthetic aperture radar (ISAR) can achieve high-resolution two-dimensional images of maneuvering targets. However, due to the indeterminate relative motion between radar and target, ISAR imaging does not provide the three-dimensional (3-D) position information of a target and suffers from great difficulty in target recognition. To tackle this issue, a 3-D interferometric ISAR (InISAR) imaging algorithm based on the joint cross modified Wigner-Ville distribution (MWVD) is presented to form 3-D images of maneuvering targets. First, we form two orthogonal interferometric baselines with three receiving antennas to establish an InISAR imaging system. Second, after the uniform range alignment and phase adjustment, the joint cross MWVD is used for all range cell of each antenna pair to generate the separation of the scatterer as well as preserve the phase that contains position information of the scatterer. At last, the 3-D images of the target can be directly reconstructed from the distribution. Simulation results demonstrate the validity of the proposal.

  9. Image-Guided Transcranial Focused Ultrasound Stimulates Human Primary Somatosensory Cortex

    Science.gov (United States)

    Lee, Wonhye; Kim, Hyungmin; Jung, Yujin; Song, In-Uk; Chung, Yong An; Yoo, Seung-Schik

    2015-03-01

    Focused ultrasound (FUS) has recently been investigated as a new mode of non-invasive brain stimulation, which offers exquisite spatial resolution and depth control. We report on the elicitation of explicit somatosensory sensations as well as accompanying evoked electroencephalographic (EEG) potentials induced by FUS stimulation of the human somatosensory cortex. As guided by individual-specific neuroimage data, FUS was transcranially delivered to the hand somatosensory cortex among healthy volunteers. The sonication elicited transient tactile sensations on the hand area contralateral to the sonicated hemisphere, with anatomical specificity of up to a finger, while EEG recordings revealed the elicitation of sonication-specific evoked potentials. Retrospective numerical simulation of the acoustic propagation through the skull showed that a threshold of acoustic intensity may exist for successful cortical stimulation. The neurological and neuroradiological assessment before and after the sonication, along with strict safety considerations through the individual-specific estimation of effective acoustic intensity in situ and thermal effects, showed promising initial safety profile; however, equal/more rigorous precautionary procedures are advised for future studies. The transient and localized stimulation of the brain using image-guided transcranial FUS may serve as a novel tool for the non-invasive assessment and modification of region-specific brain function.

  10. Charge heterogeneity of monoclonal antibodies by multiplexed imaged capillary isoelectric focusing immunoassay with chemiluminescence detection.

    Science.gov (United States)

    Michels, David A; Tu, Andrea W; McElroy, Will; Voehringer, David; Salas-Solano, Oscar

    2012-06-19

    Characterization of charge heterogeneity of recombinant monoclonal antibodies (mAbs) requires high throughput analytical methods to support clone selection and formulation screens. We applied the NanoPro technology to rapidly measure relative charge distribution of mAbs in early stage process development. The NanoPro is a multiplexed capillary-based isoelectric immunoassay with whole-column imaging detection. This assay offers specificity, speed and sensitivity advantages over conventional capillary isoelectric focusing (CIEF) platforms. After CIEF, charge variants are photochemically immobilized to the wall of a short coated capillary. Once immobilized, mAbs are probed using a secondary anti-IgG conjugated with horseradish peroxidase. After flushing away excess reagents, secondary antibodies bound to their targets are then detected by chemiluminescence upon incubation with peroxidase reactive substrates. Charge heterogeneity as determined by chemiluminescence was similar to that measured by conventional CIEF technology with absorbance detection for purified mAbs and contaminated mAbs derived directly from host cellular extract. Upon method optimization, the automated CIEF immunoassay was applied to several mAbs of varying isoelectric points, demonstrating the suitability of NanoPro as a rugged high-throughput product characterization tool. Furthermore, qualification of detection sensitivity, precision, and dynamic range are reported with discussion of its advantages as an alternative approach to rapidly characterize charge variants during process development of mAbs.

  11. Separation of Target Rigid Body and Micro-Doppler Effects in ISAR/SAR Imaging

    Science.gov (United States)

    2006-09-01

    returned from the surface of the vehicle. From micro-Doppler modulations in the engine vibration signal, one can distinguish whether it is a gas turbine...v~hicule peuvent ýtre d~tect~es par des signaux radars r~fl~chis d la surface du v~hicule. Ak partir de mo- dulations micro-Doppler du signal de...fenetre large uine forte concentration du signal correspondant aux parties du corps rigide. La deuxi~me technique se fonide sur le traitement des

  12. A Novel Phase Compensation Method for ISAR Imaging in Wideband Radar (in English

    Directory of Open Access Journals (Sweden)

    Chen Zeng-ping

    2013-03-01

    Full Text Available This paper is proposed to eliminate the negative influence of the Rotational Phase Component (RPC on the performance of the Doppler Centroid Tracking (DCT phase compensation method. Firstly, the coherent property between adjacent echo pulses sampled directly in Intermediate Frequency (IF is analyzed in the paper. Then a coherent phase compensation method is developed to improve the Translational Phase Component (TPC estimation accuracy of DCT. Compared to the Modified DCT (MDCT algorithm, the proposed method achieves better phase compensation performance. Experimental results prove the effectiveness and efficiency of the proposed strategy.

  13. Translational motion compensation for ISAR imaging under low SNR by minimum entropy

    Science.gov (United States)

    Zhang, Lei; Sheng, Jia-lian; Duan, Jia; Xing, Meng-dao; Qiao, Zhi-jun; Bao, Zheng

    2013-12-01

    In general, conventional error correction for inverse synthetic aperture radarimaging consists of range alignment and phase adjustment, which compensate range shift and phase error, respectively. Minimum entropy-based methods have been proposed to realize range alignment and phase adjustment. However, it becomes challenging to align high-resolution profiles when strong noise presents, even using entropy minimization. Consequently, the subsequent phase adjustment fails to correct phase errors. In this article, we propose a novel method for translational motion correction, where entropy minimization is utilized to achieve range alignment and phase adjustment jointly. And, a coordinate descent algorithm is proposed to solve the optimization implemented by quasi-Newton algorithm. Moreover, a method for coarse motion estimation is also proposed for initialization in solving the optimization. Both simulated and real-measured datasets are used to confirm the effectiveness of the joint motion correction in low signal-to-noise ratio situations.

  14. Quaternion-based transformation for extraction of image-generating Doppler for ISAR

    CSIR Research Space (South Africa)

    Abdul Gaffar, MY

    2008-10-01

    Full Text Available ; as the vessel rotates clockwise, the heading increases. As a result, the heading used in this system model is given by θhs,tn = mod(180◦ + θh,tn − θbr,tn , 360◦) (3) where mod(a, b) is the modulus operation of a with b, θbr,tn denotes the bearing...

  15. The research of auto-focusing method for the image mosaic and fusion system with multi-sensor

    Science.gov (United States)

    Pang, Ke; Yao, Suying; Shi, Zaifeng; Xu, Jiangtao; Liu, Jiangming

    2013-09-01

    In modern image processing, due to the development of digital image processing, the focus of the sensor can be automatically set by the digital processing system through computation. In the other hand, the auto-focusing synchronously and consistently is one of the most important factors for image mosaic and fusion processing, especially for the system with multi-sensor which are put on one line in order to gain the wide angle video information. Different images sampled by the sensors with different focal length values will always increase the complexity of the affine matrix of the image mosaic and fusion in next, which potentially reducing the efficiency of the system and consuming more power. Here, a new fast evaluation method based on the gray value variance of the image pixel is proposed to find the common focal length value for all sensors to achieve the better image sharpness. For the multi-frame pictures that are sampled from different sensors that have been adjusted and been regarded as time synchronization, the gray value variances of the adjacent pixels are determined to generate one curve. This curve is the focus measure function which describes the relationship between the image sharpness and the focal length value of the sensor. On the basis of all focus measure functions of all sensors in the image processing system, this paper uses least square method to carry out the data fitting to imitate the disperse curves and give one objective function for the multi-sensor system, and then find the optimal solution corresponding to the extreme value of the image sharpness according to the evaluation of the objective function. This optimal focal length value is the common parameter for all sensors in this system. By setting the common focal length value, in the premise of ensuring the image sharpness, the computing of the affine matrix which is the core processing of the image mosaic and fusion which stitching all those pictures into one wide angle image will be

  16. Calibration of ultrasound backscatter temperature imaging for high-intensity focused ultrasound treatment planning.

    Science.gov (United States)

    Civale, John; Rivens, Ian; Ter Haar, Gail; Morris, Hugh; Coussios, Constantin; Friend, Peter; Bamber, Jeffrey

    2013-09-01

    High-intensity focused ultrasound (HIFU) is rapidly gaining acceptance as a non-invasive method for soft tissue tumor ablation, but improvements in the methods of treatment delivery, planning and monitoring are still required. Backscatter temperature imaging (BTI) uses ultrasound to visualize heating-induced echo strain and may be used to indicate the position of the HIFU focal region using low-power "sub-lesioning" exposure. The technique may also provide a quantitative tool for assessing the efficacy of treatment delivery if apparent strain measurements can be related to the underlying temperature rise. To obtain temperature estimates from strain measurements, the relationship between these variables has to be either measured or otherwise assumed from previous calibrations in similar tissues. This article describes experimental measurements aimed at deriving the relationship between temperature rise and apparent strain in the laboratory environment using both ex vivo bovine liver tissue samples and normothermically perfused porcine livers. A BTI algorithm was applied to radiofrequency ultrasound echo data acquired from a clinical ultrasound scanner (Z.One, Zonare Medical Systems, Mountain View, CA, USA) where the imaging probe was aligned with the focal region of a HIFU transducer. Temperature measurements were obtained using needle thermocouples implanted in the liver tissue. A series of "non-ablative" HIFU exposures giving peak temperatures below 10°C were made in three separate ex vivo bovine livers, yielding an average strain/temperature coefficient of 0.126 ± 0.088 percentage strain per degree Celsius. In the perfused porcine livers at a starting temperature of 38°C (normal body temperature) the strain/temperature coefficients were found to be 0.040 ± 0.029 percentage strain per degree Celsius. The uncertainty in these results is directly linked to the precision of the strain measurement, as well as the naturally occurring variance between different

  17. Form or function: Does focusing on body functionality protect women from body dissatisfaction when viewing media images?

    Science.gov (United States)

    Mulgrew, Kate E; Tiggemann, Marika

    2016-07-04

    We examined whether shifting young women's (N =322) attention toward functionality components of media-portrayed idealized images would protect against body dissatisfaction. Image type was manipulated via images of models in either an objectified body-as-object form or active body-as-process form; viewing focus was manipulated via questions about the appearance or functionality of the models. Social comparison was examined as a moderator. Negative outcomes were most pronounced within the process-related conditions (body-as-process images or functionality viewing focus) and for women who reported greater functionality comparison. Results suggest that functionality-based depictions, reflections, and comparisons may actually produce worse outcomes than those based on appearance.

  18. Strategy of high efficiency and refined high-intensity focused ultrasound and ultrasound monitoring imaging of thermal lesion and cavitation

    Science.gov (United States)

    Wan, Mingxi; Zhang, Siyuan; Lu, Mingzhu; Hu, Hong; Jing, Bowen; Liu, Runna; Zhong, Hui

    2017-03-01

    We proposed that high efficiency high-intensity focused ultrasound (HIFU) could be achieved by using a splitting transducer with various frequencies and focusing patterns, and explored the feasibility of using ultrafast active cavitation imaging (UACI), pulse inversion (PI) sub-harmonic cavitation imaging and bubble wavelet transform imaging for monitoring of cavitation during HIFU, as well as the ultrasonic B-mode images, differential integrated backscatter (IBS) images, Nakagami images and elastography for monitoring HIFU-induced lesion. The use of HIFU splitting transducer had the potential to increase the size of the thermal lesion in a shorter duration and may improve the ablation efficiency of HIFU and would shorten the exposure duration significantly. The spatial-temporal evolution of residual cavitation bubbles at the tissue-water interface was obtained by UACI and the results showed that the UACI had a frame rate high enough to capture the transient behavior of the cavitation bubbles. The experiments demonstrated that comparing with normal sub-harmonic and PI harmonic images, PI sub-harmonic images had higher sensitivity and CTR, which was conducive to showing cavitation bubbles. The CTR would be further improved by combining PI ultrafast plane wave transmitting with cavitation bubble wavelet transform.

  19. Design and characterization of a carbon-nanotube-based micro-focus x-ray tube for small animal imaging

    Science.gov (United States)

    Sultana, Shabana; Calderón-Colón, Xiomara; Cao, Guohua; Zhou, Otto; Lu, Jianping

    2010-04-01

    We report the progress in development of carbon nanotube (CNT) field emission micro-focus x-ray tubes for dynamic small animal imaging with high spatial and temporal resolution. Extensive electron optics simulations were performed to study the focusing structure and optimize the tube design. 3D finite element analysis was used for modeling and simulating electron beam optics. A simple and intuitive model is developed to model the field emission properties of CNT cathodes. The dependence of focus spot size and the anode current on the gate extracting voltage, the focusing voltages, the gate mesh geometry, and other geometric parameters were studied. Several tubes were built according to the optimal design. The experimentally measured focus spot size and its dependence on the focus voltages were found to be in quantitative agreement with simulations.

  20. Light Focusing and Two-Dimensional Imaging Through Scattering Media using the Photoacoustic Transmission-Matrix with an Ultrasound Array

    CERN Document Server

    Chaigne, Thomas; Katz, Ori; Bossy, Emmanuel; Gigan, Sylvain

    2014-01-01

    We implement the photoacoustic transmission-matrix approach on a two-dimensional photoacoustic imaging system, using a 15 MHz linear ultrasound array. Using a black leaf skeleton as a complex absorbing structure, we demonstrate that the photoacoustic transmission-matrix approach allows to reveal structural features that are invisible in conventional photoacoustic images, as well as to selectively control light focusing on absorbing targets, leading to a local enhancement of the photoacoustic signal.

  1. Focused ultrasound simultaneous irradiation/MRI imaging, and two-stage general kinetic model.

    Directory of Open Access Journals (Sweden)

    Sheng-Yao Huang

    Full Text Available Many studies have investigated how to use focused ultrasound (FUS to temporarily disrupt the blood-brain barrier (BBB in order to facilitate the delivery of medication into lesion sites in the brain. In this study, through the setup of a real-time system, FUS irradiation and injections of ultrasound contrast agent (UCA and Gadodiamide (Gd, an MRI contrast agent can be conducted simultaneously during MRI scanning. By using this real-time system, we were able to investigate in detail how the general kinetic model (GKM is used to estimate Gd penetration in the FUS irradiated area in a rat's brain resulting from UCA concentration changes after single FUS irradiation. Two-stage GKM was proposed to estimate the Gd penetration in the FUS irradiated area in a rat's brain under experimental conditions with repeated FUS irradiation combined with different UCA concentrations. The results showed that the focal increase in the transfer rate constant of Ktrans caused by BBB disruption was dependent on the doses of UCA. Moreover, the amount of in vivo penetration of Evans blue in the FUS irradiated area in a rat's brain under various FUS irradiation experimental conditions was assessed to show the positive correlation with the transfer rate constants. Compared to the GKM method, the Two-stage GKM is more suitable for estimating the transfer rate constants of the brain treated with repeated FUS irradiations. This study demonstrated that the entire process of BBB disrupted by FUS could be quantitatively monitored by real-time dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI.

  2. Automatic Focusing for a 675 GHz Imaging Radar with Target Standoff Distances from 14 to 34 Meters

    Science.gov (United States)

    Tang, Adrian; Cooper, Ken B.; Dengler, Robert J.; Llombart, Nuria; Siegel, Peter H.

    2013-01-01

    This paper dicusses the issue of limited focal depth for high-resolution imaging radar operating over a wide range of standoff distances. We describe a technique for automatically focusing a THz imaging radar system using translational optics combined with range estimation based on a reduced chirp bandwidth setting. The demonstarted focusing algorithm estimates the correct focal depth for desired targets in the field of view at unknown standoffs and in the presence of clutter to provide good imagery at 14 to 30 meters of standoff.

  3. Predicting older adults who return to the hospital or die within 30 days of emergency department care using the ISAR tool: subjective versus objective risk factors.

    Science.gov (United States)

    Suffoletto, Brian; Miller, Thomas; Shah, Rahul; Callaway, Clifton; Yealy, Donald M

    2016-01-01

    We sought to evaluate the ability of the Identification of Seniors At Risk (ISAR) tool to differentiate between older adult patients having a poor outcome within 30 days of emergency department (ED) care and those who do not. We compare prognostic accuracy of subjective versus objective risk factors. 202 community-dwelling patients age 65 years and older presenting to two EDs were prospectively enrolled. Participants completed the six-question ISAR and objective testing (cognition, ambulation, vision). We reviewed electronic medical records for current medications, hospitalisations in the past six months, ED disposition, length of hospital stay, subsequent ED visits or inpatient admissions or death at 30 days. Participants were given a point for each risk factor present; subjective and objective risk factors were scored separately. We tested ability of individual risk factors and scores to predict a composite outcome of subsequent ED visit, postdischarge hospitalisation or death by day 30 after the index ED visit. We computed receiver operating curve area under the curves (AUC) to determine tool discrimination. 23% of participants had a poor 30-day outcome. The optimum subjective ISAR cut-off score for screening was ≥2, which was present in 84% of participants, had a sensitivity of 91% and specificity of 19%. Using the subjective ISAR tool, the AUC was 0.66. The optimum objective ISAR-related risk cut-off score for screening was ≥3, which was present in 82% of participants, had a sensitivity of 87% and specificity of 40%. Using the objective ISAR-related tool, the AUC was 0.69. The self-reported ISAR tool did not discriminate well between older adults with or without 30-day hospital revisit or death. An optimum score of ≥2 would identify many older adults at no apparent increased risk of poor outcomes at 30 days. Using objective ISAR-related risk factors did not improve overall discrimination. Published by the BMJ Publishing Group Limited. For

  4. Electrical source imaging of interictal spikes using multiple sparse volumetric priors for presurgical epileptogenic focus localization

    Directory of Open Access Journals (Sweden)

    Gregor Strobbe

    2016-01-01

    Full Text Available Electrical source imaging of interictal spikes observed in EEG recordings of patients with refractory epilepsy provides useful information to localize the epileptogenic focus during the presurgical evaluation. However, the selection of the time points or time epochs of the spikes in order to estimate the origin of the activity remains a challenge. In this study, we consider a Bayesian EEG source imaging technique for distributed sources, i.e. the multiple volumetric sparse priors (MSVP approach. The approach allows to estimate the time courses of the intensity of the sources corresponding with a specific time epoch of the spike. Based on presurgical averaged interictal spikes in six patients who were successfully treated with surgery, we estimated the time courses of the source intensities for three different time epochs: (i an epoch starting 50 ms before the spike peak and ending at 50% of the spike peak during the rising phase of the spike, (ii an epoch starting 50 ms before the spike peak and ending at the spike peak and (iii an epoch containing the full spike time period starting 50 ms before the spike peak and ending 230 ms after the spike peak. To identify the primary source of the spike activity, the source with the maximum energy from 50 ms before the spike peak till 50% of the spike peak was subsequently selected for each of the time windows. For comparison, the activity at the spike peaks and at 50% of the peaks was localized using the LORETA inversion technique and an ECD approach. Both patient-specific spherical forward models and patient-specific 5-layered finite difference models were considered to evaluate the influence of the forward model. Based on the resected zones in each of the patients, extracted from post-operative MR images, we compared the distances to the resection border of the estimated activity. Using the spherical models, the distances to the resection border for the MSVP approach and each of the different time

  5. Multispectral UV imaging for surface analysis of MUPS tablets with special focus on the pellet distribution

    DEFF Research Database (Denmark)

    Novikova, Anna; Carstensen, Jens Michael; Rades, Thomas

    2016-01-01

    In the present study the applicability of multispectral UV imaging in combination with multivariate image analysis for surface evaluation of MUPS tablets was investigated with respect to the differentiation of the API pellets from the excipients matrix, estimation of the drug content as well as p...... image analysis is a promising approach for the automatic quality control of MUPS tablets during the manufacturing process.......In the present study the applicability of multispectral UV imaging in combination with multivariate image analysis for surface evaluation of MUPS tablets was investigated with respect to the differentiation of the API pellets from the excipients matrix, estimation of the drug content as well...... on the tablet surface allowed an estimation of the true drug content in the respective MUPS tablet. In addition, the pellet distribution in the MUPS formulations could be estimated by UV image analysis of the tablet surface. In conclusion, this study revealed that UV imaging in combination with multivariate...

  6. Precision Near-Field Reconstruction in the Time Domain via Minimum Entropy for Ultra-High Resolution Radar Imaging

    Directory of Open Access Journals (Sweden)

    Jiwoong Yu

    2017-05-01

    Full Text Available Ultra-high resolution (UHR radar imaging is used to analyze the internal structure of objects and to identify and classify their shapes based on ultra-wideband (UWB signals using a vector network analyzer (VNA. However, radar-based imaging is limited by microwave propagation effects, wave scattering, and transmit power, thus the received signals are inevitably weak and noisy. To overcome this problem, the radar may be operated in the near-field. The focusing of UHR radar signals over a close distance requires precise geometry in order to accommodate the spherical waves. In this paper, a geometric estimation and compensation method that is based on the minimum entropy of radar images with sub-centimeter resolution is proposed and implemented. Inverse synthetic aperture radar (ISAR imaging is used because it is applicable to several fields, including medical- and security-related applications, and high quality images of various targets have been produced to verify the proposed method. For ISAR in the near-field, the compensation for the time delay depends on the distance from the center of rotation and the internal RF circuits and cables. Required parameters for the delay compensation algorithm that can be used to minimize the entropy of the radar images are determined so that acceptable results can be achieved. The processing speed can be enhanced by performing the calculations in the time domain without the phase values, which are removed after upsampling. For comparison, the parameters are also estimated by performing random sampling in the data set. Although the reduced data set contained only 5% of the observed angles, the parameter optimization method is shown to operate correctly.

  7. Magnetic Resonance Imaging and Computed Tomography of the Brain-50 Years of Innovation, With a Focus on the Future.

    Science.gov (United States)

    Runge, Val M; Aoki, Shigeki; Bradley, William G; Chang, Kee-Hyun; Essig, Marco; Ma, Lin; Ross, Jeffrey S; Valavanis, Anton

    2015-09-01

    This review focuses specifically on the developments in brain imaging, as opposed to the spine, and specifically conventional, clinical, cross-sectional imaging, looking primarily at advances in magnetic resonance imaging (MRI) and computed tomography (CT). These fields are viewed from a perspective of landmark publications in the last 50 years and subsequently more in depth using sentinel publications from the last 5 years. It is also written from a personal perspective, with the authors having witnessed the evolution of both fields from their initial clinical introduction to their current state. Both CT and MRI have made tremendous advances during this time, regarding not only sensitivity and spatial resolution, but also in terms of the speed of image acquisition. Advances in CT in recent years have focused in part on reduced radiation dose, an important topic for the years to come. Magnetic resonance imaging has seen the development of a plethora of scan techniques, with marked superiority to CT in terms of tissue contrast due to the many parameters that can be assessed, and their intrinsic sensitivity. Future advances in MRI for clinical practice will likely focus both on new acquisition techniques that offer advances in speed and resolution, for example, simultaneous multislice imaging and data sparsity, and on standardization and further automation of image acquisition and analysis. Functional imaging techniques including specifically perfusion and functional magnetic resonance imaging will be further integrated into the workflow to provide pathophysiologic information that influence differential diagnosis, assist treatment decision and planning, and identify and follow treatment-related changes.

  8. A Virtual Instrument for Micro Doppler Analysis of Signals in SAR/ISAR: Parameters Estimation and Focusing Moving Targets

    Science.gov (United States)

    2014-12-01

    markings if applicable.) UNCLASSIFIED 2b. CONTROLLED GOODS (NON-CONTROLLED GOODS) DMC A REVIEW : GCEC APRIL 2011 3. TITLE (The complete document title as... bibliographic announcement of this document. This will normally correspond to the Document Availability (11). However, where further distribution (beyond

  9. Comparison of Through-Focus Image Quality Across Five Presbyopia-Correcting Intraocular Lenses (An American Ophthalmological Society Thesis)

    Science.gov (United States)

    Pepose, Jay S.; Wang, Daozhi; Altmann, Griffith E.

    2011-01-01

    Purpose To assess through-focus polychromatic image sharpness of five US Food and Drug Administration–approved presbyopia-correcting intraocular lenses (IOLs) through a range of object vergences and pupil diameters utilizing an image sharpness algorithm. Methods A 1951 US Air Force resolution target was imaged through a Crystalens AO (AO) (Bausch & Lomb Surgical, Aliso Viejo, California), Crystalens HD (HD) (Bausch & Lomb Surgical, Aliso Viejo, California), aspheric ReSTOR +4.0 (R4) (Alcon Laboratories, Fort Worth, Texas), aspheric ReSTOR +3.0 (R3) (Alcon Laboratories, Fort Worth, Texas), and Tecnis Multifocal Acrylic (TMF) (Abbott Medical Optics, Irvine, California) IOL in an anatomically and optically accurate model eye and captured digitally for each combination of pupil diameter and object vergence. The sharpness of each digital image was objectively scored using a two-dimensional gradient function. Results The AO lens had the best distance image sharpness for all pupil diameters, followed by the HD. With a 5-mm pupil, the R4 lens achieved distance image quality similar to the HD, but inferior to the AO. The R3 successfully moved the near focal point farther from the patient compared to the R4, but did not improve image sharpness at intermediate distances and showed worse distance and near image sharpness. Consistent with apodization, the ReSTOR IOLs displayed better distance and poorer near image sharpness as pupil diameter increased. The TMF lens showed consistent distance and near image sharpness across pupil diameters and exhibited the best near image sharpness for all pupil diameters. Conclusions Differing IOL design strategies to increase depth of field are associated with quantifiable differences in image sharpness at varying vergences and pupil sizes. An objective comparison of the imaging properties of specific presbyopia-correcting IOLs, in conjunction with patients’ pupil sizes, can be useful in selecting the most appropriate IOL for each patient

  10. Shadow effects in simulated ultrasound images derived from computed tomography images using a focused beam tracing model

    DEFF Research Database (Denmark)

    Pham, An Hoai; Lundgren, Bo; Stage, Bjarne

    2012-01-01

    Simulation of ultrasound images based on computed tomography (CT) data has previously been performed with different approaches. Shadow effects are normally pronounced in ultrasound images, so they should be included in the simulation. In this study, a method to capture the shadow effects has been...

  11. Trends in the utilization of medical imaging from 2003 to 2011: clinical encounters offer a complementary patient-centered focus.

    Science.gov (United States)

    Dodoo, Martey S; Duszak, Richard; Hughes, Danny R

    2013-07-01

    The aim of this study was to investigate trends in utilization and spending for medical imaging, using medical visits resulting in imaging as a novel metric of utilization. Utilization and spending for medical imaging were examined using (1) Medicare Part B claims data from 2003 to 2011 to measure per-enrollee spending and (2) household component events data on the elderly Medicare-age population from the Medical Expenditure Panel Survey from 2003 to 2010 to measure utilization as a function of clinical encounters. Annual health spending and Medicare payments for imaging for the elderly population grew from $294 per enrollee in 2003 to $418 in 2006 and had declined to $390 by 2011. Over this entire time, however, annual medical visits by a similar Medicare-age (≥ 65 years old) population resulting in imaging trended consistently downward, from 12.8% in 2003 to 10.6% in 2011. Despite early growth and then more recent declines in average Medicare spending per enrollee since 2003, the percentage of patient encounters resulting in medical imaging has significantly and consistently declined nationwide. Spending alone is thus an incomplete measure of changes in the role and utilization of medical imaging in overall patient care. As policymakers focus on medical imaging, a thoughtful analysis of payment policy influencing imaging utilization, and its role in concurrent and downstream patient care, will be critical to ensure appropriate patient access. Copyright © 2013 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  12. Multi-parametric monitoring and assessment of high-intensity focused ultrasound (HIFU) boiling by harmonic motion imaging for focused ultrasound (HMIFU): an ex vivo feasibility study.

    Science.gov (United States)

    Hou, Gary Y; Marquet, Fabrice; Wang, Shutao; Konofagou, Elisa E

    2014-03-07

    Harmonic motion imaging for focused ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method with feasibilities demonstrated in vitro and in vivo. Here, a multi-parametric study is performed to investigate both elastic and acoustics-independent viscoelastic tissue changes using the Harmonic Motion Imaging (HMI) displacement, axial compressive strain and change in relative phase shift during high energy HIFU treatment with tissue boiling. Forty three (n = 43) thermal lesions were formed in ex vivo canine liver specimens (n = 28). Two-dimensional (2D) transverse HMI displacement maps were also obtained before and after lesion formation. The same method was repeated in 10 s, 20 s and 30 s HIFU durations at three different acoustic powers of 8, 10, and 11 W, which were selected and verified as treatment parameters capable of inducing boiling using both thermocouple and passive cavitation detection (PCD) measurements. Although a steady decrease in the displacement, compressive strain, and relative change in the focal phase shift (Δϕ) were obtained in numerous cases, indicating an overall increase in relative stiffness, the study outcomes also showed that during boiling, a reverse lesion-to-background displacement contrast was detected, indicating potential change in tissue absorption, geometrical change and/or, mechanical gelatification or pulverization. Following treatment, corresponding 2D HMI displacement images of the thermal lesions also mapped consistent discrepancy in the lesion-to-background displacement contrast. Despite the expectedly chaotic changes in acoustic properties with boiling, the relative change in phase shift showed a consistent decrease, indicating its robustness to monitor biomechanical properties independent of the acoustic property changes throughout the HIFU treatment. In addition, the 2D HMI displacement images confirmed and indicated the increase in the thermal lesion size with

  13. Multi-parametric monitoring and assessment of High Intensity Focused Ultrasound (HIFU) boiling by Harmonic Motion Imaging for Focused Ultrasound (HMIFU): An ex vivo feasibility study

    Science.gov (United States)

    Hou, Gary Y.; Marquet, Fabrice; Wang, Shutao; Konofagou, Elisa E.

    2014-01-01

    Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method with feasibilities demonstrated in vitro and in vivo. Here, a multi-parametric study is performed to investigate both elastic and acoustics-independent viscoelastic tissue changes using the Harmonic Motion Imaging (HMI) displacement, axial compressive strain and change in relative phase-shift during high energy HIFU treatment with tissue boiling. Forty three (n=43) thermal lesions were formed in ex vivo canine liver specimens (n=28). Two dimensional (2D) transverse HMI displacement maps were also obtained before and after lesion formation. The same method was repeated in 10-s, 20-s and 30-s HIFU durations at three different acoustic powers of 8, 10, and 11W, which were selected and verified as treatment parameters capable of inducing boiling using both thermocouple and Passive Cavitation Detection (PCD) measurements. Although a steady decrease in the displacement, compressive strain, and relative change in the focal phase shift (Δφ) were obtained in numerous cases, indicating an overall increase in relative stiffness, the study outcomes also showed that during boiling, a reverse lesion-to-background displacement contrast was detected, indicating potential change in tissue absorption, geometrical change and/or, mechanical gelatification or pulverization. Following treatment, corresponding 2D HMI displacement images of the thermal lesions also mapped consistent discrepancy in the lesion-to-background displacement contrast. Despite unpredictable changes in acoustic properties with boiling, the relative change in phase shift showed a consistent decrease, indicating its robustness to monitor biomechanical properties independent of the acoustic property change throughout the HIFU treatment. In addition, the 2D HMI displacement images confirmed and indicated the increase in the thermal lesion size with treatment duration

  14. Photoacoustic Tomography Imaging of the Adult Zebrafish by Using Unfocused and Focused High-Frequency Ultrasound Transducers

    Directory of Open Access Journals (Sweden)

    Yubin Liu

    2016-11-01

    Full Text Available The zebrafish model provides an essential platform for the study of human diseases or disorders due to the possession of about 87% homologous genes with human. However, it is still very challenging to noninvasively visualize the structure and function of adult zebrafish based on available optical imaging techniques. In this study, photoacoustic tomography (PAT was utilized for high-resolution imaging of adult zebrafish by using focused and unfocused high-frequency (10 MHz ultrasound transducers. We examined and compared the imaging results from the two categories of transducers with in vivo experimental tests, in which we discovered that the unfocused transducer is able to identify the inner organs of adult zebrafish with higher contrast but limited regional resolution, whereas the findings from the focused transducer were with high resolution but limited regional contrast for the recovered inner organs.

  15. Imaging findings of various calvarial bone lesions witha focus on osteolytic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Yim, Young Hee; Moon, Won Jin; An, Hyeong Su; Cho, Joon [Konkuk University Medical Center, Konkuk University School of Medicine, Seoul (Korea, Republic of); Rho, Myung Ho [Dept. of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2016-01-15

    In this review, we present computed tomography (CT) and magnetic resonance imaging (MRI) findings of various calvarial lesions on the basis of their imaging patterns and list the differential diagnoses of the lesions. We retrospectively reviewed 256 cases of calvarial lesion (122 malignant neoplasms, 115 benign neoplasms, and 19 non-neoplastic lesions) seen in our institutions, and classified them into six categories based on the following imaging features: generalized skull thickening, focal skull thickening, generalized skull thinning, focal skull thinning, single lytic lesion, and multiple lytic lesions. Although bony lesions of the calvarium are easily identified on CT, bone marrow lesions are better visualized on MRI including diffusion-weighted imaging or fat-suppressed T2-weighted imaging. Careful interpretation of calvarial lesions based on pattern recognition can effectively narrow a range of possible diagnoses.

  16. In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion).

    Science.gov (United States)

    Singh, Mithun Kuniyil Ajith; Jaeger, Michael; Frenz, Martin; Steenbergen, Wiendelt

    2016-08-01

    Reflection artifacts caused by acoustic inhomogeneities are a critical problem in epi-mode biomedical photoacoustic imaging. High light fluence beneath the probe results in photoacoustic transients, which propagate into the tissue and reflect back from echogenic structures. These reflection artifacts cause problems in image interpretation and significantly impact the contrast and imaging depth. We recently proposed a method called PAFUSion (Photoacoustic-guided focused ultrasound) to identify such reflection artifacts in photoacoustic imaging. In its initial version, PAFUSion mimics the inward-travelling wavefield from small blood vessel-like PA sources by applying ultrasound pulses focused towards these sources, and thus provides a way to identify the resulting reflection artifacts. In this work, we demonstrate reduction of reflection artifacts in phantoms and in vivo measurements on human volunteers. In view of the spatially distributed PA sources that are found in clinical applications, we implemented an improved version of PAFUSion where photoacoustic signals are backpropagated to imitate the inward travelling wavefield and thus the reflection artifacts. The backpropagation is performed in a synthetic way based on the pulse-echo acquisitions after transmission on each single element of the transducer array. The results provide a direct confirmation that reflection artifacts are prominent in clinical epi-photoacoustic imaging, and that PAFUSion can strongly reduce these artifacts to improve deep-tissue photoacoustic imaging.

  17. Radiologic findings of hemophilic arthropathy of the knee : Focusing on MR imaging and plain radiography

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Jin; Choi, Jae Young; Cha, Sung Suk; Eun, Choong Kie [Inje Univ., College of Medicine, Pusan (Korea, Republic of); Park, Dong Woo [Hanyang Univ., College of Medicine, Seoul (Korea, Republic of)

    1996-12-01

    To evaluate the characteristic MR findings of hemophilic arthropathy of the knee. Seven keens in six patients with hemophilia (five hemophilia A and one hemophilia B) were retrospectively studied with MR images and plain radiographs. Patients were aged between 2 and 20 years (mean, 11) and all had a clinical history of repeated hemarthrosis. MR images of the knee were analyzed with respect to intra- and extra-articular hemorrhage, the state of synovial tissue, articular cartilage, bone, menisci, and ligaments. Synovial hypertrophy and articular cartilage destruction were revealed in all seven knees ; pannus was found in four, and was seen as low signal intensity on T1-weighted image and high signal intensity on T2-weighted images. All five instances of synovial hypertrophy and pannus were enhanced. Joint effusion, presented in five of seven knees, demonstrated slightly low signal intensity on T1-weighted image and high signal intensity on T2-weighted images, and was associated with peripheral low signal intensity of hemosiderin. Subchondral and marginal erosion was seen in six cases, patellar deformity in three, meniscal damage in four and cruciate ligament damage in one case. MR is superior to radiography in demonstrating chronic repeated hemarthrosis (manifested as thick intra-articular effusion), hemosidering, synovial hypertrophy, erosion or destruction of articular cartilage and bone, and meniscal or cruciate ligament injury of hemophilic arthropathy of the knee. MR is therefore thought to be a useful imaging study for accurate evaluation of hemophilic arthropathy of the knee.

  18. Efficacy of Increasing Focus to Film Distance (FFD for Patient’s Dose and Image Quality in Pediatric Chest Radiography

    Directory of Open Access Journals (Sweden)

    Vahid Karami

    2016-09-01

    Full Text Available Background: Increasing the x-ray focus to film distance (FFD has been advocated as an effective method to reduce the patients’ radiation dose. The aim of this study was to investigate the efficacy of this technique in patients' dose and image quality in pediatric chest x-ray.Material and methods: Sixty pediatric patients were x-ray imaged at FFDs of 100 and 130 cm. Dose measurements were performed using thermo-luminescent dosimeters (GR200. The quality of images was independently assessed using the anatomical criteria recommended by the European guidelines.Results: Increasing the FFD from 100 to 130 cm has reduced the entrance skin dose (ESD of patients by 32.2% (p 0.05.Conclusion: Increased FFD to 130 cm reduce the pediatric radiation dose with no significant changes in image quality.

  19. Reflection-mode photoacoustic microscopy using a hollow focused ultrasound transducer for in vivo imaging of blood vessels

    Institute of Scientific and Technical Information of China (English)

    Yuan Yi; Yang Si-Hua

    2012-01-01

    A reflection-mode photoacoustic microscope using a hollow focused ultrasound transducer is developed for highresolution in vivo imaging.A confocal structure of the laser and the ultrasound is used to improve the system resolution.The axial and lateral resolutions of the system are measured to be~32 μm and~58 μm,respectively.Ex vivo and in vivo modes are tested to validate the imaging capability of the photoacoustic microscope.The adjacent vein and artery can be seen clearly from the reconstructed photoacoustic images.The results demonstrate that the reflectionmode photoacoustic microscope can be used for high-resolution imaging of micro-blood vessels,which would be of great benefit for monitoring the neovascularization in tumor angiogenesis.

  20. Radar Imaging and Target Identification

    Science.gov (United States)

    2005-08-24

    fast ISAR imaging algorithm, related to my work with Brett Borden, based on a suggestion from Emmanuel Cand~s. 4 Chapter 2 Current Status of Effort...were Lee Potter (Ohio State) , Miijdat 4ýetin (MIT), bf Alan Willsky (MIT), Todd Hale (AFIT), Brian Rigling (Wright State U., a for- mer student of...met Todd Hale and Marshall Greenspan (Norden Systems, Northrup Grum- man); the latter turned out to be on the same departing flight out of Huntsville

  1. Acute pelvic inflammatory disease: pictorial essay focused on computed tomography and magnetic resonance imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Febronio, Eduardo Miguel; Rosas, George de Queiroz; D' Ippolito, Giuseppe, E-mail: giuseppe_dr@uol.com.br [Department of Imaging Diagnosis, Escola Paulista de Medicina - Universidade Federal de Sao Paulo (EPMUnifesp), Sao Paulo, SP (Brazil)

    2012-11-15

    The present study was aimed at describing key computed tomography and magnetic resonance imaging findings in patients with acute abdominal pain derived from pelvic inflammatory disease. Two radiologists consensually selected and analyzed computed tomography and magnetic resonance imaging studies performed between January 2010 and December 2011 in patients with proven pelvic inflammatory disease leading to presentation of acute abdomen. Main findings included presence of intracavitary fluid collections, anomalous enhancement of the pelvic excavation and densification of adnexal fat planes. Pelvic inflammatory disease is one of the leading causes of abdominal pain in women of childbearing age and it has been increasingly been diagnosed by means of computed tomography and magnetic resonance imaging supplementing the role of ultrasonography. It is crucial that radiologists become familiar with the main sectional imaging findings in the diagnosis of this common cause of acute abdomen (author)

  2. Ectopic pregnancy: pictorial essay focusing on computed tomography and magnetic resonance imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Febronio, Eduardo Miguel; Rosas, George de Queiroz; D' Ippolito, Giuseppe [Escola Paulista de Medicina - Universidade Federal de Sao Paulo (EPM-Unifesp), Sao Paulo, SP (Brazil). Dept. of Imaging Diagnosis; Cardia, Patricia Prando, E-mail: giuseppe_dr@uol.com.br [Centro Radiologico Campinas, Campinas, SP (Brazil)

    2012-09-15

    The objective of the present study is to describe key computed tomography and magnetic resonance imaging findings in patients with acute abdominal pain caused by ectopic pregnancy. For this purpose, two radiologists consensually selected and analyzed computed tomography and magnetic resonance imaging studies performed in female patients with acute abdominal pain caused by proven ectopic pregnancy in the period between January 2010 and December 2011. The imaging diagnosis of ectopic pregnancy is usually obtained by ultrasonography, however, with the increasing use of computed tomography and magnetic resonance imaging in the assessment of patients with acute abdomen of gynecological origin it is necessary that the radiologist becomes familiar with the main findings observed at these diagnostic methods. (author)

  3. Multi-focus Image Fusion by SML in the Shearlet Subbands

    Directory of Open Access Journals (Sweden)

    Jianguo Yang

    2013-07-01

    Full Text Available It is now widely acknowledged that traditional wavelets are not very effective in dealing with multidimensional signals containing distributed discontinuities. Shearlet Transform is a new discrete multiscale directional representation, which combines the power of multiscale methods with a unique ability to capture the geometry of multidimensional data and is optimally efficient in representing images containing edges. In this work, coefficients with greater Sum-Modified-Laplacian are selected to combine images when high-frequency and low-frequency Shearlet subbands of source images are compared. Numerical experiments demonstrate that the method base on Shearlet Transform and Sum-Modified-Laplacian is very competitive and better than other multi-scale geometric analysis tools in multifocus image fusion both in terms of objectives performance and objective criteria.

  4. MIIP: a web-based platform for medical image interpretation training and evaluation focusing on ultrasound

    Science.gov (United States)

    Lindseth, Frank; Nordrik Hallan, Marte; Schiller Tønnessen, Martin; Smistad, Erik; Vâpenstad, Cecilie

    2017-03-01

    Introduction: Medical imaging technology has revolutionized health care over the past 30 years. This is especially true for ultrasound, a modality that an increasing amount of medical personal is starting to use. Purpose: The purpose of this study was to develop and evaluate a platform for improving medical image interpretation skills regardless of time and space and without the need for expensive imaging equipment or a patient to scan. Methods, results and conclusions: A stable web application with the needed functionality for image interpretation training and evaluation has been implemented. The system has been extensively tested internally and used during an international course in ultrasound-guided neurosurgery. The web application was well received and got very good System Usability Scale (SUS) scores.

  5. Post-operative orbital imaging: a focus on implants and prosthetic devices

    Energy Technology Data Exchange (ETDEWEB)

    Adams, Ashok [Royal London Hospital, Diagnostic Neuroradiology, Barts Health NHS Trust, London (United Kingdom); Mankad, Kshitij [Great Ormond Street Hospital, Diagnostic Neuroradiology, London (United Kingdom); Poitelea, Cornelia; Verity, David H. [Moorfields Eye Hospital, London (United Kingdom); Davagnanam, Indran [National Hospital for Neurology and Neurosurgery, London (United Kingdom)

    2014-11-15

    Accurate interpretation of orbital imaging in the presence of either orbital implants requires a sound knowledge of both the surgical approach used and the imaging characteristics of the implanted devices themselves. In this article, the radiological appearance of the various devices used in ophthalmology, and their relationship to other orbital structures, is reviewed. In addition, the intended anatomical location, function of these devices, and clinical indications for their use are provided. (orig.)

  6. SYSIPHE: focus on SIELETERS, the medium and longwave infrared spectral imaging instrument

    Science.gov (United States)

    Ferrec, Yann; Rousset-Rouvière, Laurent; Coudrain, Christophe; Primot, Jérôme; Thétas, Sophie; Kattnig, Alain

    2014-05-01

    Sysiphe is an airborne hyperspectral imaging system, result of a cooperation between France (Onera and DGA) and Norway (NEO and FFI). It is a unique system by its spatial sampling -0.5m with a 500m swath at a ground height of 2000m- combined with its wide spectral coverage -from 0.4μm to 11.5μm in the atmospheric transmission bands. Its infrared component, named Sieleters, consists in two high étendue imaging static Fourier transform spectrometers, one for the midwave infrared and one for the longwave infrared. These two imaging spectrometers have very close design, since both are made of a Michelson interferometer, a refractive imaging system, and a large IRFPA (1016x440 pixels). Moreover, both are cryogenic and mounted on their own stabilization platform which allows at once to actively control and independently measure the line of sigh. These data are useful to reconstruct and to georeference the spectral image from the raw interferometric images. Sysiphe first flight occurred in September, 2013.

  7. Metamaterial fibres for subdiffraction imaging and focusing at terahertz frequencies over optically long distances

    National Research Council Canada - National Science Library

    Tuniz, Alessandro; Kaltenecker, Korbinian J; Fischer, Bernd M; Walther, Markus; Fleming, Simon C; Argyros, Alexander; Kuhlmey, Boris T

    2013-01-01

    .... Wire array metamaterials, because of their extreme anisotropy, can beat this limit; however, focusing with these has only been demonstrated up to microwave frequencies and using propagation over a few wavelengths only...

  8. Wavelet-transform-based active imaging of cavitation bubbles in tissues induced by high intensity focused ultrasound.

    Science.gov (United States)

    Liu, Runna; Xu, Shanshan; Hu, Hong; Huo, Rui; Wang, Supin; Wan, Mingxi

    2016-08-01

    Cavitation detection and imaging are essential for monitoring high-intensity focused ultrasound (HIFU) therapies. In this paper, an active cavitation imaging method based on wavelet transform is proposed to enhance the contrast between the cavitation bubbles and surrounding tissues. The Yang-Church model, which is a combination of the Keller-Miksis equation with the Kelvin-Voigt equation for the pulsations of gas bubbles in simple linear viscoelastic solids, is utilized to construct the bubble wavelet. Experiments with porcine muscles demonstrate that image quality is associated with the initial radius of the bubble wavelet and the scale. Moreover, the Yang-Church model achieves a somewhat better performance compared with the Rayleigh-Plesset-Noltingk-Neppiras-Poritsky model. Furthermore, the pulse inversion (PI) technique is combined with bubble wavelet transform to achieve further improvement. The cavitation-to-tissue ratio (CTR) of the best tissue bubble wavelet transform (TBWT) mode image is improved by 5.1 dB compared with that of the B-mode image, while the CTR of the best PI-based TBWT mode image is improved by 7.9 dB compared with that of the PI-based B-mode image. This work will be useful for better monitoring of cavitation in HIFU-induced therapies.

  9. Pupil-phase optimization for extended-focus, aberration-corrected imaging systems

    Science.gov (United States)

    Prasad, Sudhakar; Pauca, V. Paul; Plemmons, Robert J.; Torgersen, Todd C.; van der Gracht, Joseph

    2004-10-01

    The insertion of a suitably designed phase plate in the pupil of an imaging system makes it possible to encode the depth dimension of an extended three-dimensional scene by means of an approximately shift-invariant PSF. The so-encoded image can then be deblurred digitally by standard image recovery algorithms to recoup the depth dependent detail of the original scene. A similar strategy can be adopted to compensate for certain monochromatic aberrations of the system. Here we consider two approaches to optimizing the design of the phase plate that are somewhat complementary - one based on Fisher information that attempts to reduce the sensitivity of the phase encoded image to misfocus and the other based on a minimax formulation of the sum of singular values of the system blurring matrix that attempts to maximize the resolution in the final image. Comparisons of these two optimization approaches are discussed. Our preliminary demonstration of the use of such pupil-phase engineering to successfully control system aberrations, particularly spherical aberration, is also presented.

  10. Application of the laser generated focused-Lamb wave for non-contact imaging of defects in plate.

    Science.gov (United States)

    Jhang, Kyung-Young; Shin, Min Jae; Lim, Byoung Ok

    2006-12-22

    The laser generation method of focused-Lamb wave is expected to have high defect-detection ability with advantages of non-contact testing. In this method, the laser beam is illuminated on the surface of the object through an arrayed-arc slit, and then the energy of the generated Lamb wave is concentrated on the focus point of arc. This focusing effect enables the concentration of higher wave intensity on the focus with better S/N ratio of signal, and has better spatial resolution compared to the conventional line arrayed method. This paper describes a 2-D imaging system using this laser generated, focused-Lamb wave combined with its detection by the air-coupled transducer. This technique is fully non-contact so it can be easily applied for the automatic inspection. The effectiveness of the proposed method was verified by experiments on a 1-mm thick aluminum plate with artificial drill-hole defect with diameters of 1mm. The 2-D image of was constructed by scanning and the result showed that the location and size of defects were clearly detected.

  11. Development of a spherically focused phased array transducer for ultrasonic image-guided hyperthermia

    Science.gov (United States)

    Liu, Jingfei; Foiret, Josquin; Stephens, Douglas N.; Le Baron, Olivier; Ferrara, Katherine W.

    2016-07-01

    A 1.5 MHz prolate spheroidal therapeutic array with 128 circular elements was designed to accommodate standard imaging arrays for ultrasonic image-guided hyperthermia. The implementation of this dual-array system integrates real-time therapeutic and imaging functions with a single ultrasound system (Vantage 256, Verasonics). To facilitate applications involving small animal imaging and therapy the array was designed to have a beam depth of field smaller than 3.5 mm and to electronically steer over distances greater than 1 cm in both the axial and lateral directions. In order to achieve the required f number of 0.69, 1-3 piezocomposite modules were mated within the transducer housing. The performance of the prototype array was experimentally evaluated with excellent agreement with numerical simulation. A focal volume (2.70 mm (axial)  ×  0.65 mm (transverse)  ×  0.35 mm (transverse)) defined by the  -6 dB focal intensity was obtained to address the dimensions needed for small animal therapy. An electronic beam steering range defined by the  -3 dB focal peak intensity (17 mm (axial)  ×  14 mm (transverse)  ×  12 mm (transverse)) and  -8 dB lateral grating lobes (24 mm (axial)  ×  18 mm (transverse)  ×  16 mm (transverse)) was achieved. The combined testing of imaging and therapeutic functions confirmed well-controlled local heating generation and imaging in a tissue mimicking phantom. This dual-array implementation offers a practical means to achieve hyperthermia and ablation in small animal models and can be incorporated within protocols for ultrasound-mediated drug delivery.

  12. Analyzer-based phase-contrast imaging system using a micro focus x-ray source

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Wei [BME Department, Illinois Institute of Technology, Chicago, Illinois 60616 (United States); Majidi, Keivan; Brankov, Jovan G., E-mail: brankov@iit.edu [ECE Department, Illinois Institute of Technology, Chicago, Illinois 60616 (United States)

    2014-08-15

    Here we describe a new in-laboratory analyzer based phase contrast-imaging (ABI) instrument using a conventional X-ray tube source (CXS) aimed at bio-medical imaging applications. Phase contrast-imaging allows visualization of soft tissue details usually obscured in conventional X-ray imaging. The ABI system design and major features are described in detail. The key advantage of the presented system, over the few existing CXS ABI systems, is that it does not require high precision components, i.e., CXS, X-ray detector, and electro-mechanical components. To overcome a main problem introduced by these components, identified as temperature stability, the system components are kept at a constant temperature inside of three enclosures, thus minimizing the electrical and mechanical thermal drifts. This is achieved by using thermoelectric (Peltier) cooling/heating modules that are easy to control precisely. For CXS we utilized a microfocus X-ray source with tungsten (W) anode material. In addition the proposed system eliminates tungsten's multiple spectral lines by selecting monochromator crystal size appropriately therefore eliminating need for the costly mismatched, two-crystal monochromator. The system imaging was fine-tuned for tungsten Kα{sub 1} line with the energy of 59.3 keV since it has been shown to be of great clinical significance by a number of researchers at synchrotron facilities. In this way a laboratory system that can be used for evaluating and quantifying tissue properties, initially explored at synchrotron facilities, would be of great interest to a larger research community. To demonstrate the imaging capability of our instrument we use a chicken thigh tissue sample.

  13. Tracking and imaging of dynamic objects in scattering media by time-reversed adapted-perturbation (TRAP) optical focusing

    CERN Document Server

    Ma, Cheng; Liu, Yan; Wang, Lihong V

    2014-01-01

    The ability to steer light propagation inside scattering media has long been sought-after due to its potential widespread applications. To form optical foci inside scattering media, the only feasible strategy is to guide photons by using either implanted or virtual guide stars. However, all of these guide stars must be introduced extrinsically, either invasively or by physical contact, limiting the scope of their application. Here, we focus light inside scattering media by employing intrinsic dynamics as guide stars. By time-reversing the perturbed component of the scattered light adaptively, we concentrate light to the origin of the perturbation, where the permittivity varied spontaneously. We demonstrate dynamic light focusing onto moving targets and imaging of a time-variant object obscured by highly scattering media, without invasiveness and physical contact. Anticipated applications include all-weather optical communication with airplanes or satellites, tracking vehicles in thick fogs, and imaging and ph...

  14. Temporal-spatial MTF performance analysis of a proximity-focused-image intensifier as a camera electronic shutter

    Science.gov (United States)

    Xiang, Shiming; Zhu, Hongquan; Wang, Kuilu

    2007-01-01

    A specially designed-Proximity-focused-MCP-Image Intensifier (MCP-II) has been widely used for a high speed diagnosis system as a ns-level-electronic shutter. Its temporal-spatial (dynamic) MTF or resolution are much concerned in the engineering for single exposure conditions of various shutter times, and input illuminations as well. On basis of the theory of Fourier spectrum and signal-to-noise, it has been analyzed in present paper that dynamic-MTF (or resolution) of the MCP-II system is always deteriorated by its limited temporal frequency bandwidth, as well as S/N performance. Several expressions are given to relate the device's dynamic MTF (or resolution) to its static MTF, input illumination and S/N performances. The theoretical analysis is very useful in evaluating and designing some high speed diagnosis systems with a proximity-focused-image intensifier as a electronic shutter.

  15. Color multi-focus image fusion algorithm based on fuzzy theory and dual-tree complex wavelet transform

    Directory of Open Access Journals (Sweden)

    Yan Sun

    2017-06-01

    Full Text Available This paper puts forward a new color multi-focus image fusion algorithm based on fuzzy theory and dual-tree complex wavelet transform for the purpose of removing uncertainty when choosing sub-band coefficients in the smooth regions. Luminance component is the weighted average of the three color channels in the IHS color space and it is not sensitive to noise. According to the characteristics, luminance component was chosen as the measurement to calculate the focus degree. After separating the luminance component and spectrum component, Fisher classification and fuzzy theory were chosen as the fusion rules to conduct the choice of the coefficients after the dual-tree complex wavelet transform. So fusion color image could keep the natural color information as much as possible. This method could solve the problem of color distortion in the traditional algorithms. According to the simulation results, the proposed algorithm obtained better visual effects and objective quantitative indicators.

  16. Segmentation Method of Time-Lapse Microscopy Images with the Focus on Biocompatibility Assessment.

    Science.gov (United States)

    Soukup, Jindřich; Císař, Petr; Šroubek, Filip

    2016-06-01

    Biocompatibility testing of new materials is often performed in vitro by measuring the growth rate of mammalian cancer cells in time-lapse images acquired by phase contrast microscopes. The growth rate is measured by tracking cell coverage, which requires an accurate automatic segmentation method. However, cancer cells have irregular shapes that change over time, the mottled background pattern is partially visible through the cells and the images contain artifacts such as halos. We developed a novel algorithm for cell segmentation that copes with the mentioned challenges. It is based on temporal differences of consecutive images and a combination of thresholding, blurring, and morphological operations. We tested the algorithm on images of four cell types acquired by two different microscopes, evaluated the precision of segmentation against manual segmentation performed by a human operator, and finally provided comparison with other freely available methods. We propose a new, fully automated method for measuring the cell growth rate based on fitting a coverage curve with the Verhulst population model. The algorithm is fast and shows accuracy comparable with manual segmentation. Most notably it can correctly separate live from dead cells.

  17. Report on the second prototype of non-imaging focusing heliostat and its application in food processing

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.T.; Chong, K.K.; Lim, C.S.; Lim, B.H.; Tan, B.K.; Lu, Y.F. [University of Science and Technology of China (China). Dept. of Astronomy and Applied Physics

    2005-09-01

    Following our previous report on the first prototype of non-imaging focusing heliostat, this second prototype has presented much improvement not only in the respect of structure but also in the method of controlling. The principle and practice of these changes have been reported in the article. The development of the new heliostat which is closer to cost effectiveness may bring some commercial interest. Solar potato peeling studied here is provided as one example. (author)

  18. Imaging high-intensity focused ultrasound-induced tissue denaturation by multispectral photoacoustic method: an ex vivo study.

    Science.gov (United States)

    Sun, Yao; O'Neill, Brian

    2013-03-10

    We present an ex vivo study for the first time, to the best of our knowledge, in multispectral photoacoustic imaging (PAI) of tissue denaturation induced by high-intensity focused ultrasound (HIFU) in this paper. Tissue of bovine muscle was thermally treated in a heated water bath and by HIFU, and then was imaged using a multispectral photoacoustic approach. Light at multiple optical wavelengths between 700 and 900 nm was delivered to the treated bovine muscle tissue to excite the photoacoustic signal. Apparent tissue denaturation has been observed in multispectral photoacoustic images after being treated in a water bath and by HIFU. It is interesting that the denaturation is more striking at shorter optical wavelength photoacoustic images than at longer optical wavelength photoacoustic images. Multispectral photoacoustic images of the tissue denaturation were further analyzed and the photoacoustic spectrums of the denaturized tissue were calculated in this paper. This study suggests that a multispectral PAI approach might be a promising tool to evaluate tissue denaturation induced by HIFU treatment.

  19. Study on radiation dose in the medical image data display method-focus on the DICOM standard

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Su [Dept. of Radio-technology, Health Welfare, Wonkwang Health Science University, Iksan (Korea, Republic of)

    2015-12-15

    DICOM (Digital Imaging and Communications in Medicine) standards are generally introduced as de facto and de jure standards in modern medical imaging devices to store and to transmit medical image information. DICOM Dose Structured Report (DICOM dose SR) is implemented to report radiation exposure information in image acquiring process. and DIOCM Modality Performed Procedure Step (DICOM MPPS) is also partly used to report this exposure with the information in its DICOM tag. This article is focused on three type of radiation exposure information of DICOM standards, 1) DICOM dose SR, 2) DICOM MPPS and 3) Radiation Exposure Monitoring(REM) profile by Integrating the Healthcare Enterprise(IHE), to study on radiation exposure reporting. Healthcare facility and its staff of medical imaging related to radiation exposure should have a deep understanding of radiation exposure, and it required a standards to enhance the quality control of medical imaging and the safety of patients and staffs. Staff member have to pay attention on radiation exposures and controlling processes from the purchasing stage of X-ray devices.

  20. 红外高光谱成像的光谱聚焦%Spectrally focusing in hyperspectral imaging IR system

    Institute of Scientific and Technical Information of China (English)

    孟卫华; 倪国强; 高昆; 向静波; 项建胜

    2013-01-01

      文中将光学系统中能量聚焦的概念引申至光谱维,提出在红外高光谱成像系统中通过信号处理获取感兴趣目标与其环境的光谱特征差异,结合调控目标函数得到光谱聚焦调控参数,进而控制成像系统中的可调谐部件自适应调谐到最有利探测和识别的若干个光谱通道,实现光谱聚焦。文中提出了一种可实现光谱聚焦的系统构型,重点探讨了光谱聚焦的机制和实现途径,给出了关键分系统的技术方案。利用光谱聚焦可以实现光谱自适应探测,提高光谱成像信息利用效率,降低信息处理的资需求,有助提高系统的实时性和小型化,对弹载、无人机载等高实时性、无人参与的应用具有十分重要意义。%Focusing in optics was extended to spectral dimension in this paper, and the method of spectrally focusing was proposed. The spectrally focusing was implemented by adaptively tuning of a F-P optical cavity tunable filter, which was controlled by the parameters from the regulation and control function driven by the differences between interesting object and its background. An hyperspectral imaging IR system with spectrally focusing was introduced, and the practical scheme of main subsystem was contrived, the mechanism and approach to spectrally focusing were investigated. With spectrally focusing, spectrally adaptive detection can be achieved, the hyperspectral images can be utilized more efficiently, and thereby the ability demand for image processing is reduced. Spectrally focusing conduces to make hyperspectral imaging IR system more rapid and compact, which suits with the utilization in missile or UAV.

  1. Study on cavitation behavior during high-intensity focused ultrasound exposure by using optical and ultrasonic imaging

    Science.gov (United States)

    Taguchi, Kei; Takagi, Ryo; Yasuda, Jun; Yoshizawa, Shin; Umemura, Shin-ichiro

    2016-07-01

    Cavitation bubbles are known to enhance the heating effect of high-intensity focused ultrasound (HIFU). In our previous study, the use of a “triggered HIFU” sequence consisting of a high-intensity pulse and a relatively low-intensity burst was proposed as an effective method to utilize the effect of cavitation bubbles. However, the duration of each component in the sequence has not been optimized. In this study, optical imaging was carried out to observe the behavior of cavitation bubbles in a gel phantom during the triggered HIFU exposure. Ultrasound imaging using the pulse inversion method was also conducted to detect the behavior of the bubbles. The results suggest that the oscillation of cavitation bubbles become inactive as the duration of HIFU burst exposure increases to the order of 10 ms. It was also suggested that ultrasonic imaging has potential use for detecting a change in the oscillation of cavitation bubbles for optimizing a triggered HIFU sequence.

  2. MR imaging findings of pineal germinoma: focus on differential diagnosis from other germ cell tumors

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Jin; Lee, Ho Kyu; Kim, Jae Kyun; Shin, Ji Hoon; Choi, Choong Gon; Lee, Myung Jun; Ham, Soo Youn; Lee, Jong Hwa; Suh, Dae Chul [Ulsan Univ. College of Medicine, Seoul (Korea, Republic of)

    1998-10-01

    To determine the characteristic MR imaging findings of pineal germinoma, and differential diagnosis from other germ cell tumors. MR images of patients with histopathologically proven pineal germinoma(n=3D14) and other pineal germ cell tumors(n=3D10) were retrospectively analyzed with regard to size, signal intensity and homogeneity, enhancing features, cyst formation, and multiplicity of lesions. Other pineal germ cell tumors were the mixed germ cell tumors (n=3D4), malignant teratomas (n=3D3), choriocarcinoma(n=3D1), embryonal carcinoma(n=3D1), and endodermal sinus tumor(n=3D1). Tumor markers were evaluated. On T1-weighted images, germinomas showed homogeneous(86%) or iso signal intensity (93%), while other germ cell tumors showed inhomogeneous(70%) or iso signal intensity(70%). On T2-weighted images, germinomas showed homogeneous(64%) or iso signal intensity(57%), while other germ cell tumors showed inhomogeneous(70%) or high signal intensity(80%). On Gd-DTPA enhanced images, germinomas showed homogeneous (93%) or strong enhancement (64%), while other germ cell tumors showed homogeneous(60%) or strong enhancement (70%). Cyst formation was noted in ten Patients (71%) with germinoma and in six (60%) with other germ cell tumors. Invasion on surrounding structures was seen in 11 patients (79%) with germinoma and in five (50%) with other germ cell tumors. Lesions were multiple in three patients(21%) with germinoma. Thirteen of 14 patients with germinoma had normal serum {alpha}-FP(tetoprotein) and {beta}-HCG(human chononic gonafotrophin) levels. Two of four patients with mixed germ cell tumors had elevated serum {beta}-FP and {alpha}-HCG levels; in the ther two, elevated serum {alpha}-FP or {beta}-HCG levels were noted. In the malignant teratoma and embryonal carcinoma patients, serum {alpha}-FP and {beta}-HCG levels were normal. The patient with choriocarcinoma had an elevated serum {beta}-HCG level. On T1W1, the only significant differential point (p<0.01) between

  3. [Imaging of the elbow joint with focus MRI. Part 2: muscles, nerves and synovial membranes].

    Science.gov (United States)

    Rehm, J; Zeifang, F; Weber, M-A

    2014-03-01

    This review article discusses the magnetic resonance imaging (MRI) features and pathological changes of muscles, nerves and the synovial lining of the elbow joint. Typical imaging findings are illustrated and discussed. In addition, the cross-sectional anatomy and anatomical variants, such as accessory muscles and plicae are discussed. Injuries of the muscles surrounding the elbow joint, as well as chronic irritation are particularly common in athletes. Morphological changes in MRI, for example tennis or golfer's elbow are typical and often groundbreaking. By adapting the examination sequences, imaging planes and slices, complete and incomplete tendon ruptures can be reliably diagnosed. Although the clinical and electrophysiological examinations form the basis for the diagnosis of peripheral neuropathies, MRI provides useful additional information about the precise localization due to its high resolution and good soft tissue contrast and helps to rule out differential diagnoses. Synovial diseases, such as inflammatory arthritis, proliferative diseases and also impinging plicae must be considered in the MRI diagnostics of the elbow joint.

  4. A new double imaging velocity focusing coincidence experiment: i{sup 2}PEPICO

    Energy Technology Data Exchange (ETDEWEB)

    Bodi, Andras; Hemberger, Patrick; Gerber, Thomas [Paul Scherrer Institut, Villigen 5232 (Switzerland); Sztaray, Balint [Department of Chemistry, University of the Pacific, Stockton, California 95211 (United States)

    2012-08-15

    The vacuum ultraviolet (VUV) beamline of the Swiss Light Source has been upgraded after two years of operation. A new, turntable-type monochromator was constructed at the Paul Scherrer Institut, which allows for fast yaw-alignment as well as quick grating change and exchange. In addition to the original imaging photoelectron photoion coincidence endstation (iPEPICO), a second, complementary double imaging setup (i{sup 2}PEPICO) has been built. Volatile samples can be introduced at room temperature or in a molecular beam, a pyrolysis source allows for radical production, and non-volatile solids can be evaporated in a heated cell. Monochromatic VUV radiation ionizes the sample and both photoelectrons and photoions are velocity map imaged onto two fast position sensitive detectors and detected in delayed coincidence. High intensity synchrotron radiation leads to ionization rates above 10{sup 5} s{sup -1}. New data acquisition and processing approaches are discussed for recording coincidence processes at high rates. The setup is capable of resolving pulsed molecular beam profiles and the synchrotron time structure temporally. The latter is shown by photoelectron autocorrelation, which displays both the 1.04 MHz ring clock frequency as well as resolving the micro-pulses with a separation of 2 ns. Kinetic energy release analysis on the dissociative photoionization of CF{sub 4} indicates a dissociation mechanism change in the Franck-Condon allowed energy range of the first ion state.

  5. An intelligent nanotheranostic agent for targeting, redox-responsive ultrasound imaging, and imaging-guided high-intensity focused ultrasound synergistic therapy.

    Science.gov (United States)

    Wang, Xia; Chen, Hangrong; Zhang, Kun; Ma, Ming; Li, Faqi; Zeng, Deping; Zheng, Shuguang; Chen, Yu; Jiang, Lixin; Xu, Huixiong; Shi, Jianlin

    2014-04-09

    A novel multifunctional nanotheranostic agent with targeting, redox-responsive ultrasound imaging and ultrasound imaging-guided high-intensity focused ultrasound (HIFU) therapy (MSNC-PEG-HA(SS)-PFH, abbreviated as MPH(SS)-PFH) capabilities is developed. The redox-responsive guest molecule release and ultrasound imaging functions can be both integrated in such a "smart" theranostic agent, which is accomplished by the redox-triggered transition from the crosslinking state to retrocrosslinking state of the grafted polyethylene glycol-disulfide hyaluronic acid molecules on the particle surface when reaching a reducing environment in vitro. More importantly, under the tailored ultrasound imaging guiding, in vivo Hela tumor-bearing nude mice can be thoroughly and spatial-accurately ablated during HIFU therapy, due to the targeted accumulation, responsive ultrasound imaging guidance and the synergistic ablation functions of nanotheranostic agent MPH(SS)-PFH in the tumors. This novel multifunctional nano-platform can serve as a promising candidate for further studies on oncology therapy, due to its high stability, responsive and indicative ultrasound imaging of tumors, and enhanced HIFU therapeutic efficiency and spatial accuracy under ultrasound-guidance.

  6. Transrectal high-intensity focused ultrasound ablation of prostate cancer: Effective treatment requiring accurate imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Olivier.rouviere@netcourrier.com; Souchon, Remi [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: souchon@lyon.inserm.fr; Salomir, Rares [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: salomir@lyon.inserm.fr; Gelet, Albert [Hospices Civils de Lyon, Department of Urology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France)], E-mail: Albert.gelet@chu-lyon.fr; Chapelon, Jean-Yves [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: chapelon@lyon.inserm.fr; Lyonnet, Denis [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Denis.lyonnet@chu-lyon.fr

    2007-09-15

    Transrectal HIFU ablation has become a reasonable option for the treatment of localized prostate cancer in non-surgical patients, with 5-year disease-free survival similar to that of radiation therapy. It is also a promising salvage therapy of local recurrence after radiation therapy. These favourable results are partly due to recent improvements in prostate cancer imaging. However, further improvements are needed in patient selection, pre-operative localization of the tumor foci, assessment of the volume treated and early detection of recurrence. A better knowledge of the factors influencing the HIFU-induced tissue destruction and a better pre-operative assessment of them by imaging techniques should improve treatment outcome. Whereas prostate HIFU ablation is currently performed under transrectal ultrasound guidance, MR guidance with real-time operative monitoring of temperature will be available in the near future. If this technique will give better targeting and more uniform tissue destruction, its cost-effectiveness will have to be carefully evaluated. Finally, a recently reported synergistic effect between HIFU ablation and chemotherapy opens possibilities for treatment in high-risk or clinically advanced tumors.

  7. Examining the Choroid in Ocular Inflammation: A Focus on Enhanced Depth Imaging

    Directory of Open Access Journals (Sweden)

    Abeir Baltmr

    2014-01-01

    Full Text Available The choroid is the vascular layer that supplies the outer retina and is involved in the pathogenesis of several ocular conditions including choroidal tumors, age related macular degeneration, central serous chorioretinopathy, diabetic retinopathy, and uveitis. Nevertheless, difficulties in the visualization of the choroid have limited our understanding of its exact role in ocular pathology. Enhanced depth imaging optical coherent topography (EDI-OCT is a novel, noninvasive technique that is used to evaluate choroidal thickness and morphology in these diseases. The technique provides detailed objective in vivo visualization of the choroid and can be used to characterize posterior segment inflammatory disorders, monitor disease activity, and evaluate efficacy of treatment. In this review we summarize the current application of this technique in ocular inflammatory disorders and highlight its utility as an additional tool in monitoring choroidal involvement in ocular inflammation.

  8. Focusing and imaging with increased numerical apertures through multimode fibers with micro-fabricated optics

    KAUST Repository

    Bianchi, Silvio

    2013-01-01

    The use of individual multimode optical fibers in endoscopy applications has the potential to provide highly miniaturized and noninvasive probes for microscopy and optical micromanipulation. A few different strategies have been proposed recently, but they all suffer from intrinsically low resolution related to the low numerical aperture of multimode fibers. Here, we show that two-photon polymerization allows for direct fabrication of micro-optics components on the fiber end, resulting in an increase of the numerical aperture to a value that is close to 1. Coupling light into the fiber through a spatial light modulator, we were able to optically scan a submicrometer spot (300 nm FWHM) over an extended region, facing the opposite fiber end. Fluorescence imaging with improved resolution is also demonstrated. © 2013 Optical Society of America.

  9. From images to text: focusing and anaphoric devices usage in child and young adults’ narratives

    Directory of Open Access Journals (Sweden)

    Ana Borzone

    2013-08-01

    Full Text Available This study aims to analyze the use of anaphoric expressions for introducing, re-introducing and maintaining referents in children and teenagers Spanish-speaking narrative productions from a picture book. We try to explore whether they are able to produce an autonomous narrative text by the adequate use of correferential mechanisms. Four groups of children, aged 5, 8, 11 and 16, took part in his study. Results showed that all groups performance is similar with regard to the prevailing use of FN to introduce and re-introduce agent in focus and subjects omissions for referential continuity. But in 5 years old children narratives, the use of deictic forms is very frequent, fact that indicats their difficulty to produce autonomous texts. In the other group’s narratives a significant increment in the control over the linguistic cohesive resources was observed.

  10. Characterization of new FPS (Focus Projection and Scale) vidicons for scientific imaging applications

    Science.gov (United States)

    Yates, G. J.; Jaramillo, S. A.; Holmes, V. H.; Black, J. P.

    1988-06-01

    Several new photoconductors now commercially available as targets in Type 7803 FPS (Focus Projection and Scan) electrostatically focussed vidicons have been characterized for use as radiometric sensors in transient illumination and single frame applications. These include Saticon (Se + Te + As), Newvicon (ZnSe), Pasecon (CdSe), and Plumbicon (PbO). Samples from several domestic and foreign manufacturers have been evaluated for photoconductive response time and responsivity at selected narrow wavelength bands, including 410 nm, 560 nm, and 822 nm. These data are compared with performance data from older target materials including antimony trisulfide (Sb2S3) and silicon. Dynamic range and resolution trade-offs as functions of read-beam aperture diameter and raster size are also presented. The point spread functions for standard 1-mil vidicons and for increased apertures of 1.5, 2.0, 3.0, and 4.0-mil are also discussed.

  11. Magnetic resonance image-guided versus ultrasound-guided high-intensity focused ultrasound in the treatment of breast cancer

    Institute of Scientific and Technical Information of China (English)

    Sheng Li; Pei-Hong Wu

    2013-01-01

    Image-guided high-intensity focused ultrasound (HIFU) has been used for more than ten years,primarily in the treatment of liver and prostate cancers.HIFU has the advantages of precise cancer ablation and excellent protection of healthy tissue.Breast cancer is a common cancer in women.HIFU therapy,in combination with other therapies,has the potential to improve both oncologic and cosmetic outcomes for breast cancer patients by providing a curative therapy that conserves mammary shape.Currently,HIFU therapy is not commonly used in breast cancer treatment,and efforts to promote the application of HIFU is expected.In this article,we compare different image-guided models for HIFU and reviewed the status,drawbacks,and potential of HIFU therapy for breast cancer.

  12. Cost-effective solar furnace system using fixed geometry Non-Imaging Focusing Heliostat and secondary parabolic concentrator

    Energy Technology Data Exchange (ETDEWEB)

    Chong, K.K.; Lim, C.Y.; Hiew, C.W. [Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Off Jalan Genting Kelang, Setapak, Kuala Lumpur 53300 (Malaysia)

    2011-05-15

    A novel cost-effective solar furnace system is proposed to be consisted of a Non-Imaging Focusing Heliostat (NIFH) and a much smaller parabolic concentrator. In order to simplify the design and hence leading to the cost reduction, a fixed geometry of the NIFH heliostat is adopted in the novel solar furnace system by omitting the requirement of continuous astigmatic correction throughout the year with the use of local controllers. The performance of this novel solar furnace configuration can be optimized when the heliostat's spinning-axis is orientated in such a way that the annual variations of incident angle and therefore the annual variations of aberrant image size are the least. To verify the new configuration, a prototype solar furnace has been constructed at Universiti Tunku Abdul Rahman. (author)

  13. HERO: Program Status and Fist Images from a Balloon-Borne Focusing Hard-X-ray Telescope

    Science.gov (United States)

    Ramsey, B. D.; Alexander, C. D.; Apple, J. A.; Benson, C. M.; Dietz, K. L.; Elsner, R. F.; Engelhaupt. D. E.; Ghosh, K. K.; Kolodziejczak, J. J.; ODell, S. L.; hide

    2001-01-01

    HERO is a balloon payload featuring shallow-graze angle replicated optics for hard-x-ray imaging. When completed, the instrument will offer unprecedented sensitivity in the hard-x-ray region, giving thousands of sources to choose from for detailed study on long flights. A recent proof-of-concept flight captured the first hard-x-ray focused images of the Crab Nebula, Cygnus X-1 and GRS 1915+105. Full details of the HERO program are presented, including the design and performance of the optics, the detectors and the gondola. Results from the recent proving flight are discussed together with expected future performance when the full science payload is completed.

  14. Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imaging

    Science.gov (United States)

    Thériault, Gabrielle; Cottet, Martin; Castonguay, Annie; McCarthy, Nathalie; De Koninck, Yves

    2014-01-01

    Two-photon microscopy has revolutionized functional cellular imaging in tissue, but although the highly confined depth of field (DOF) of standard set-ups yields great optical sectioning, it also limits imaging speed in volume samples and ease of use. For this reason, we recently presented a simple and retrofittable modification to the two-photon laser-scanning microscope which extends the DOF through the use of an axicon (conical lens). Here we demonstrate three significant benefits of this technique using biological samples commonly employed in the field of neuroscience. First, we use a sample of neurons grown in culture and move it along the z-axis, showing that a more stable focus is achieved without compromise on transverse resolution. Second, we monitor 3D population dynamics in an acute slice of live mouse cortex, demonstrating that faster volumetric scans can be conducted. Third, we acquire a stereoscopic image of neurons and their dendrites in a fixed sample of mouse cortex, using only two scans instead of the complete stack and calculations required by standard systems. Taken together, these advantages, combined with the ease of integration into pre-existing systems, make the extended depth-of-field imaging based on Bessel beams a strong asset for the field of microscopy and life sciences in general. PMID:24904284

  15. Imaging of the autonomic nervous system: focus on cardiac sympathetic innervation.

    Science.gov (United States)

    Goldstein, David S

    2003-12-01

    Symptoms or signs of abnormal autonomic nervous system function occur commonly in several neurological disorders. Clinical evaluations have depended on physiological, pharmacological, and neurochemical approaches. Recently, imaging of sympathetic noradrenergic innervation has been introduced and applied especially in the heart. Most studies have used the radiolabeled sympathomimetic amine, (123)I-metaiodobenzylguanidine. Decreased uptake or increased "washout" of (123)I-metaiodobenzylguanidine-derived radioactivity is associated with worse prognosis or more severe disease in hypertension, congestive heart failure, arrhythmias, and diabetes mellitus. This pattern may reflect a high rate of postganglionic sympathetic nerve traffic to the heart. Many recent studies have agreed on the remarkable finding that all patients with Parkinson's disease and orthostatic hypotension have a loss of cardiac sympathetic innervation, whereas all patients with multiple system atrophy, often difficult to distinguish clinically from Parkinson's disease, have intact cardiac sympathetic innervation. Because Parkinson's disease entails a postganglionic sympathetic noradrenergic lesion, the disease appears to be not only a movement disorder, with dopamine loss in the nigrostriatal system of the brain, but also a dysautonomia, with noradrenaline loss in the sympathetic nervous system of the heart. As new ligands are developed, one may predict further discoveries of involvement of components of the autonomic nervous system in neurological diseases.

  16. Images of Environmental Management: Competing Metaphors in Focus Group Discussions of Swedish Environmental Quality Objectives

    Science.gov (United States)

    Wibeck, Victoria

    2012-04-01

    In managing environmental problems, several countries have chosen the management by objectives (MBO) approach. This paper investigates how focus group participants from the Swedish environmental administration used metaphors to describe the mode of organization needed to attain environmental objectives. Such analysis can shed light on how an MBO system is perceived by actors and how it works in practice. Although the Swedish government intended to stimulate broad-based cooperation among many actors, participants often saw themselves as located at a certain "level," i.e., "higher" or "lower," in the MBO system—that is, their conceptions corresponded to a traditional, hierarchical interpretation of MBO. Prepositions such as "in" and "out" contributed to feelings of inclusion and exclusion on the part of MBO actors. However, horizontal metaphors merged with vertical ones, indicating ongoing competition for the right to interpret how the system of environmental objectives should best be managed. The paper concludes that any organization applying MBO could benefit from discussing alternate ways of talking and thinking about its constituent "levels."

  17. Non-invasive cardiac pacing with image-guided focused ultrasound

    Science.gov (United States)

    Marquet, Fabrice; Bour, Pierre; Vaillant, Fanny; Amraoui, Sana; Dubois, Rémi; Ritter, Philippe; Haïssaguerre, Michel; Hocini, Mélèze; Bernus, Olivier; Quesson, Bruno

    2016-11-01

    Currently, no non-invasive cardiac pacing device acceptable for prolonged use in conscious patients exists. High Intensity Focused Ultrasound (HIFU) can be used to perform remote pacing using reversibility of electromechanical coupling of cardiomyocytes. Here we described an extracorporeal cardiac stimulation device and study its efficacy and safety. We conducted experiments ex vivo and in vivo in a large animal model (pig) to evaluate clinical potential of such a technique. The stimulation threshold was determined in 10 different ex vivo hearts and different clinically relevant electrical effects such as consecutive stimulations of different heart chambers with a single ultrasonic probe, continuous pacing or the inducibility of ventricular tachycardia were shown. Using ultrasonic contrast agent, consistent cardiac stimulation was achievable in vivo for up to 1 hour sessions in 4 different animals. No damage was observed in inversion-recovery MR sequences performed in vivo in the 4 animals. Histological analysis revealed no differences between stimulated and control regions, for all ex vivo and in vivo cases.

  18. Focus on the controversial aspects of 64Cu-ATSM in tumoral hypoxia mapping by PET imaging

    Directory of Open Access Journals (Sweden)

    Mathilde eColombié

    2015-08-01

    Full Text Available Mapping tumor hypoxia is a great challenge in Positron Emission Tomography (PET imaging as the precise functional information of the biological processes is needed for many effective therapeutic strategies. Tumor hypoxia has been widely reported as a poor prognostic indicator and is often associated with tumor aggressiveness, chemo and radio resistance. An accurate diagnosis of hypoxia is a challenge and is crucial for providing accurate treatment for patients’ survival benefits. This challenge has led to the emergence of new and novel PET tracers for the functional and metabolic characterization of tumor hypoxia non-invasively. Among these tracers, copper semicarbazone compound, [64Cu]- diacetyl-bis(N4 methylthiosemicarbazone (=64Cu-ATSM has been developed as a tracer for hypoxia imaging. This review focuses on 64Cu-ATSM PET imaging and the concept is presented in two sections. The first section describes its in vitro development and pre-clinical testing and particularly its affinity in different cell lines. The second section describes the controversial reports on its specificity for hypoxia imaging. The review concludes that 64Cu-ATSM - more than a hypoxic tracer, exhibits tracer accumulation in tumor which is linked to the redox potential and reactive oxygen species (ROS. The authors concluded that 64Cu-ATSNM is a marker of over-reduced cell state and thus an indirect marker for hypoxia imaging. The affinity of 64Cu-ATSM for over reduced cells was observed to be a complex phenomenon. And to provide a definitive and convincing mechanism, more in vivo studies are needed to prove the diagnostic utility of 64Cu-ATSM.

  19. Image Shutters: Gated Proximity-Focused Microchannel-Plate (MCP) Wafer Tubes Versus Gated Silicon Intensified Target (SIT) Vidicons

    Science.gov (United States)

    Yates, G. J.; King, N. S. P.; Jaramillo, S. A.; Ogle, J. W.; Noel, B. W.; Thayer, N. N.

    1983-03-01

    The imaging characteristics of two fast image shutters used for recording the spatial and temporal evolution of transient optical events in the nanosecond range have been studied. Emphasis is on the comparative performances of each shutter type under similar conditions. Response data, including gating speed, gain, dynamic range, shuttering efficiency, and resolution for 18 and 25-mm-diam proximity-focused microchannel-plate (MCP) intensifiers are com-pared with similar data for a prototype electrostatically-focused 25-mm-diam gated silicon-intensified-target (SIT) vidicon currently under development for Los Alamos National Laboratory. Several key parameters critical to optical gating speed have been varied in both tube types in order to determine the optimum performance attainable from each design. These include conductive substrate material and thickness used to reduce photocathode resistivity, spacing between gating electrodes to minimize interelectrode capacitance, the use of con-ductive grids on the photocathode substrate to permit rapid propagation of the electrical gate pulse to all areas of the photocathode, and different package geometries to provide a more effective interface with external biasing and gating circuitry. For comparable spatial resolution, most 18-mm-diam MCPs require gate times > 2.5 ns while the fastest SIT has demonstrated sub-nanosecond optical gates as short as r 400 ± 50 ps for full shuttering of the 25-mm-diam input window.

  20. Characterization of continuous and pulsed emission modes of a hybrid micro focus x-ray source for medical imaging applications

    Science.gov (United States)

    Ghani, Muhammad U.; Wong, Molly D.; Ren, Liqiang; Wu, Di; Zheng, Bin; Rong, John. X.; Wu, Xizeng; Liu, Hong

    2017-05-01

    The aim of this study was to quantitatively characterize a micro focus x-ray tube that can operate in both continuous and pulsed emission modes. The micro focus x-ray source (Model L9181-06, Hamamatsu Photonics, Japan) has a varying focal spot size ranging from 16 μm to 50 μm as the source output power changes from 10 to 39 W. We measured the source output, beam quality, focal spot sizes, kV accuracy, spectra shapes and spatial resolution. Source output was measured using an ionization chamber for various tube voltages (kVs) with varying current (μA) and distances. The beam quality was measured in terms of half value layer (HVL), kV accuracy was measured with a non-invasive kV meter, and the spectra was measured using a compact integrated spectrometer system. The focal spot sizes were measured using a slit method with a CCD detector with a pixel pitch of 22 μm. The spatial resolution was quantitatively measured using the slit method with a CMOS flat panel detector with a 50 μm pixel pitch, and compared to the qualitative results obtained by imaging a contrast bar pattern. The focal spot sizes in the vertical direction were smaller than that of the horizontal direction, the impact of which was visible when comparing the spatial resolution values. Our analyses revealed that both emission modes yield comparable imaging performances in terms of beam quality, spectra shape and spatial resolution effects. There were no significantly large differences, thus providing the motivation for future studies to design and develop stable and robust cone beam imaging systems for various diagnostic applications.

  1. Morphology and River Monitoring - Topobathymetry as a new level of monitoring and managing the morphology at the river Isar, Munich after the flood flows 2013

    Science.gov (United States)

    Steinbacher, Frank; Schaufuß, Daniela; Aufleger, Markus; Baran, Ramona; Dobler, Wolfgang

    2014-05-01

    Topobathymetry is a new approach for the very detailed bathymetric survey of water bodies (rivers, lakes, nearshore) as well as the topographic side in a same resolution. This technique was made possible within the scope of a research project between the University of Innsbruck and Riegl LMS (Horn, Lower Austria). This airborne-operated, water-penetrating laser system capturing both sides of water's edge is considered as a technical revolution for the comprehensive and simultaneous survey and research of our countryside. Monitoring our waters area-wide and with a point density lager 20 points/m² a new data level is reached for managing them and performing research on hydraulics and morphology. By now operating the system over three years and due to the flood flows in Austria and Germany in 2013 a dataset before and after the effects of the flood could be analyzed at the river Isar. The changes monitored at the river Isar due to the flood flow will be presented as well as the new possibilities in calibrating hydro- morphologic numerical models. The project offers the city of Munich new knowledge and ways in managing inner-city river structures and planning the future of the close-to-nature approaches at the river Isar.

  2. Image processing obtained by out of focus tomography: droplet sizing measurement; Traitement d'images obtenues par tomographie defocalisee: mesure de diametres de gouttes

    Energy Technology Data Exchange (ETDEWEB)

    Mounaim-Rouselle, Ch.; Higelin, P.; Pajot, O. [Orleans Univ., Lab. de Mecanique et d' Energetique, ESEM, 45 (France)

    1999-07-01

    The objective of this paper is to show a droplet sizing technique. This method based on Mie Scattering interferometry, allows to easily get spatial droplets repartition in relatively sparse medium. It has been, in particular, applied inside an I.C. engine combustion chamber. Theoretical bases of the out-of-focus tomography are briefly reminded and also experimental limits. The image processing software is developed with Matlab and gives automatically sizing repartition for frame sequence, taken with same experimental set-up. (authors)

  3. Fast and exact method for computing a stack of images at various focuses from a four-dimensional light field

    Science.gov (United States)

    Mhabary, Ziv; Levi, Ofer; Small, Eran; Stern, Adrian

    2016-07-01

    This paper presents an efficient method for computing a stack of images digitally focused at various lengths from a four-dimensional light field (LF). The main contribution of this work is a fast and algebraically exact method that does not require interpolation in the frequency or spatial domains as alternative methods do. The proposed imaging operator combines two-dimensional (2-D) fast Fourier transform with 2-D fractional Fourier transform and has computational complexity of O(N log N), where N is the number of pixels in the LF tesseract of dimension N=nx×ny×nu×nv. The whole method consists of unitary vector-based operations; therefore, parallel implementation is easy and can contribute additional speed up. While current state of the art methods suffer from inherent tradeoff between the reconstruction quality and computational complexity, the proposed method benefits of both low-computational complexity and high-reconstruction quality. We also offer a solution for refocusing at distances that are not included in the reconstructed images stack. For such a case, we provide a modified version of our method, which is also algebraically exact and has lower computational complexity than other exact methods.

  4. Harmonic motion imaging for focused ultrasound (HMIFU): a fully integrated technique for sonication and monitoring of thermal ablation in tissues.

    Science.gov (United States)

    Maleke, C; Konofagou, E E

    2008-03-21

    FUS (focused ultrasound), or HIFU (high-intensity-focused ultrasound) therapy, a minimally or non-invasive procedure that uses ultrasound to generate thermal necrosis, has been proven successful in several clinical applications. This paper discusses a method for monitoring thermal treatment at different sonication durations (10 s, 20 s and 30 s) using the amplitude-modulated (AM) harmonic motion imaging for focused ultrasound (HMIFU) technique in bovine liver samples in vitro. The feasibility of HMI for characterizing mechanical tissue properties has previously been demonstrated. Here, a confocal transducer, combining a 4.68 MHz therapy (FUS) and a 7.5 MHz diagnostic (pulse-echo) transducer, was used. The therapy transducer was driven by a low-frequency AM continuous signal at 25 Hz, producing a stable harmonic radiation force oscillating at the modulation frequency. A pulser/receiver was used to drive the pulse-echo transducer at a pulse repetition frequency (PRF) of 5.4 kHz. Radio-frequency (RF) signals were acquired using a standard pulse-echo technique. The temperature near the ablation region was simultaneously monitored. Both RF signals and temperature measurements were obtained before, during and after sonication. The resulting axial tissue displacement was estimated using one-dimensional cross correlation. When temperature at the focal zone was above 48 degrees C during heating, the coagulation necrosis occurred and tissue damage was irreversible. The HMI displacement profiles in relation to the temperature and sonication durations were analyzed. At the beginning of heating, the temperature at the focus increased sharply, while the tissue stiffness decreased resulting in higher HMI displacements. This was confirmed by an increase of 0.8 microm degrees C(-1)(r=0.93, ptissue became irreversibly stiffer, followed by an associated decrease in the HMI displacement (-0.79 microm degrees C(-1), r=-0.92, ptissues during FUS, HIFU or other thermal therapies.

  5. Coherent diffraction imaging analysis of shape-controlled nanoparticles with focused hard X-ray free-electron laser pulses.

    Science.gov (United States)

    Takahashi, Yukio; Suzuki, Akihiro; Zettsu, Nobuyuki; Oroguchi, Tomotaka; Takayama, Yuki; Sekiguchi, Yuki; Kobayashi, Amane; Yamamoto, Masaki; Nakasako, Masayoshi

    2013-01-01

    We report the first demonstration of the coherent diffraction imaging analysis of nanoparticles using focused hard X-ray free-electron laser pulses, allowing us to analyze the size distribution of particles as well as the electron density projection of individual particles. We measured 1000 single-shot coherent X-ray diffraction patterns of shape-controlled Ag nanocubes and Au/Ag nanoboxes and estimated the edge length from the speckle size of the coherent diffraction patterns. We then reconstructed the two-dimensional electron density projection with sub-10 nm resolution from selected coherent diffraction patterns. This method enables the simultaneous analysis of the size distribution of synthesized nanoparticles and the structures of particles at nanoscale resolution to address correlations between individual structures of components and the statistical properties in heterogeneous systems such as nanoparticles and cells.

  6. Theoretical predictions for spatially-focused heating of magnetic nanoparticles guided by magnetic particle imaging field gradients

    Energy Technology Data Exchange (ETDEWEB)

    Dhavalikar, Rohan [Department of Chemical Engineering, University of Florida, 1030 Center Drive, Gainesville, FL 32611 (United States); Rinaldi, Carlos, E-mail: carlos.rinaldi@bme.ufl.edu [Department of Chemical Engineering, University of Florida, 1030 Center Drive, Gainesville, FL 32611 (United States); J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, FL 32611 (United States)

    2016-12-01

    Magnetic nanoparticles in alternating magnetic fields (AMFs) transfer some of the field's energy to their surroundings in the form of heat, a property that has attracted significant attention for use in cancer treatment through hyperthermia and in developing magnetic drug carriers that can be actuated to release their cargo externally using magnetic fields. To date, most work in this field has focused on the use of AMFs that actuate heat release by nanoparticles over large regions, without the ability to select specific nanoparticle-loaded regions for heating while leaving other nanoparticle-loaded regions unaffected. In parallel, magnetic particle imaging (MPI) has emerged as a promising approach to image the distribution of magnetic nanoparticle tracers in vivo, with sub-millimeter spatial resolution. The underlying principle in MPI is the application of a selection magnetic field gradient, which defines a small region of low bias field, superimposed with an AMF (of lower frequency and amplitude than those normally used to actuate heating by the nanoparticles) to obtain a signal which is proportional to the concentration of particles in the region of low bias field. Here we extend previous models for estimating the energy dissipation rates of magnetic nanoparticles in uniform AMFs to provide theoretical predictions of how the selection magnetic field gradient used in MPI can be used to selectively actuate heating by magnetic nanoparticles in the low bias field region of the selection magnetic field gradient. Theoretical predictions are given for the spatial decay in energy dissipation rate under magnetic field gradients representative of those that can be achieved with current MPI technology. These results underscore the potential of combining MPI and higher amplitude/frequency actuation AMFs to achieve selective magnetic fluid hyperthermia (MFH) guided by MPI. - Highlights: • SAR predictions based on a field-dependent magnetization relaxation model.

  7. Focused ultrasound enhanced molecular imaging and gene therapy for multifusion reporter gene in glioma-bearing rat model.

    Science.gov (United States)

    Yang, Feng-Yi; Chang, Wen-Yuan; Lin, Wei-Ting; Hwang, Jeng-Jong; Chien, Yi-Chun; Wang, Hsin-Ell; Tsai, Min-Lan

    2015-11-03

    The ability to monitor the responses of and inhibit the growth of brain tumors during gene therapy has been severely limited due to the blood-brain barrier (BBB). A previous study has demonstrated the feasibility of noninvasive in vivo imaging with 123I-2'-fluoro-2'-deoxy-5-iodo-1-β-D-arabinofuranosyluracil (123I-FIAU) for monitoring herpes simplex virus type 1 thymidine kinase (HSV1-tk) cancer gene expression in an experimental animal model. Here, we tested the enhancement of SPECT with 123I-FIAU and ganciclovir (GCV) treatment in brain tumors after BBB disruption induced by focused ultrasound (FUS) in the presence of microbubbles. We established an orthotopic F98 glioma-bearing rat model with trifusion reporter genes. The results of this study showed that the rat model of HSV1-tk-expressing glioma cells could be successfully detected by SPECT imaging after FUS-induced BBB disruption on day 10 after implantation. Compared to the control group, animals receiving the GCV with or without sonication exhibited a significant antitumor activity (P therapy in brain diseases.

  8. PET/MR in oncology: an introduction with focus on MR and future perspectives for hybrid imaging

    Science.gov (United States)

    Balyasnikova, Svetlana; Löfgren, Johan; de Nijs, Robin; Zamogilnaya, Yanna; Højgaard, Liselotte; Fischer, Barbara M

    2012-01-01

    After more than 20 years of research, a fully integrated PET/MR scanner was launched in 2010 enabling simultaneous acquisition of PET and MR imaging. Currently, no clinical indication for combined PET/MR has been established, however the expectations are high. In this paper we will discuss some of the challenges inherent in this new technology, but focus on potential applications for simultaneous PET/MR in the field of oncology. Methods and tracers for use with the PET technology will be familiar to most readers of this journal; thus this paper aims to provide a short and basic introduction to a number of different MRI techniques, such as DWI-MR (diffusion weighted imaging MR), DCE-MR (dynamic contrast enhanced MR), MRS (MR spectroscopy) and MR for attenuation correction of PET. All MR techniques presented in this paper have shown promising results in the treatment of patients with solid tumors and could be applied together with PET increasing the amount of information about the tissues of interest. The potential clinical benefit of applying PET/MR in staging, radiotherapy planning and treatment evaluation in oncology, as well as the research perspectives for the use of PET/MR in the development of new tracers and drugs will be discussed. PMID:23145362

  9. Non-invasive Measurement of Thermal Diffusivity Using High-Intensity Focused Ultrasound and Through-Transmission Ultrasonic Imaging.

    Science.gov (United States)

    Yeshurun, Lilach; Azhari, Haim

    2016-01-01

    Thermal diffusivity at the site ablated by high-intensity focused ultrasound (HIFU) plays an important role in the final therapeutic outcome, as it influences the temperature's spatial and temporal distribution. Moreover, as tissue thermal diffusivity is different in tumors as compared with normal tissue, it could also potentially be used as a new source of imaging contrast. The aim of this study was to examine the feasibility of combining through-transmission ultrasonic imaging and HIFU to estimate thermal diffusivity non-invasively. The concept was initially evaluated using a computer simulation. Then it was experimentally tested on phantoms made of agar and ex vivo porcine fat. A computerized imaging system combined with a HIFU system was used to heat the phantoms to temperatures below 42°C to avoid irreversible damage. Through-transmission scanning provided the time-of-flight values in a region of interest during its cooling process. The time-of-flight values were consequently converted into mean values of speed of sound. Using the speed-of-sound profiles along with the developed model, we estimated the changes in temperature profiles over time. These changes in temperature profiles were then used to calculate the corresponding thermal diffusivity of the studied specimen. Thermal diffusivity for porcine fat was found to be lower by one order of magnitude than that obtained for agar (0.313×10(-7)m(2)/s vs. 4.83×10(-7)m(2)/s, respectively, p ultrasound thermal diffusivity mapping is feasible. The suggested method may particularly be suitable for breast scanning.

  10. 3D imaging of cells and tissues by focused ion beam/scanning electron microscopy (FIB/SEM).

    Science.gov (United States)

    Drobne, Damjana

    2013-01-01

    Integration of a scanning electron microscope (SEM) and focused ion beam (FIB) technology into a single FIB/SEM system permits use of the FIB as a nano-scalpel to reveal site-specific subsurface microstructures which can be examined in great detail by SEM. The FIB/SEM technology is widely used in the semiconductor industry and material sciences, and recently its use in the life sciences has been initiated. Samples for FIB/SEM investigation can be either embedded in a plastic matrix, the traditional means of preparation of transmission electron microscopy (TEM) specimens, or simply dried as in samples prepared for SEM imaging. Currently, FIB/SEM is used in the life sciences for (a) preparation by the lift-out technique of lamella for TEM analysis, (b) tomography of samples embedded in a matrix, and (c) in situ site-specific FIB milling and SEM imaging using a wide range of magnifications. Site-specific milling and imaging has attracted wide interest as a technique in structural research of single eukaryotic and prokaryotic cells, small animals, and different animal tissue, but it still remains to be explored more thoroughly. In the past, preparation of samples for site-specific milling and imaging by FIB/SEM has typically adopted the embedding techniques used for TEM samples, and which have been very well described in the literature. Sample preparation protocols for the use of dried samples in FIB/SEM have been less well investigated. The aim of this chapter is to encourage application of FIB/SEM on dried biological samples. A detailed description of conventional dried sample preparation and FIB/SEM investigation of dried biological samples is presented. The important steps are described and illustrated, and direct comparison between embedded and dried samples of same tissues is provided. The ability to discover links between gross morphology of the tissue or organ, surface characteristics of any selected region, and intracellular structural details on the nanometer

  11. Detection systems for mass spectrometry imaging: a perspective on novel developments with a focus on active pixel detectors

    NARCIS (Netherlands)

    Jungmann, JH; Heeren, R.M.A.

    2013-01-01

    Instrumental developments for imaging and individual particle detection for biomolecular mass spectrometry (imaging) and fundamental atomic and molecular physics studies are reviewed. Ion-counting detectors, array detection systems and highmass detectors for mass spectrometry (imaging) are treated.

  12. The impact of appearance-focused social comparisons on body image disturbance in the naturalistic environment: the roles of thin-ideal internalization and feminist beliefs.

    Science.gov (United States)

    Myers, Taryn A; Ridolfi, Danielle R; Crowther, Janis H; Ciesla, Jeffery A

    2012-06-01

    Drawing on Festinger's (1954) social comparison theory and its modern applications, this research investigated the relationship between upward appearance-focused social comparisons and body image disturbance using ecological momentary assessment, which allows for examination of these phenomena in their natural context. Participants were 91 undergraduate women who answered questionnaires five times per day for five days using Palm Personal Data Assistant (PDA) devices. Analyses were conducted using hierarchical linear modeling, which allows for examination of longitudinal data both within and across participants. Results revealed a positive relationship between upward appearance-focused social comparisons and body image disturbance. Upward appearance-focused social comparisons were associated with greater body image disturbance for those with higher levels of thin-ideal internalization and with greater body checking for women with lower levels of feminist beliefs. These findings further illuminate the nature of the relationship between social comparisons and body image disturbance.

  13. Theoretical predictions for spatially-focused heating of magnetic nanoparticles guided by magnetic particle imaging field gradients

    Science.gov (United States)

    Dhavalikar, Rohan; Rinaldi, Carlos

    2016-12-01

    Magnetic nanoparticles in alternating magnetic fields (AMFs) transfer some of the field's energy to their surroundings in the form of heat, a property that has attracted significant attention for use in cancer treatment through hyperthermia and in developing magnetic drug carriers that can be actuated to release their cargo externally using magnetic fields. To date, most work in this field has focused on the use of AMFs that actuate heat release by nanoparticles over large regions, without the ability to select specific nanoparticle-loaded regions for heating while leaving other nanoparticle-loaded regions unaffected. In parallel, magnetic particle imaging (MPI) has emerged as a promising approach to image the distribution of magnetic nanoparticle tracers in vivo, with sub-millimeter spatial resolution. The underlying principle in MPI is the application of a selection magnetic field gradient, which defines a small region of low bias field, superimposed with an AMF (of lower frequency and amplitude than those normally used to actuate heating by the nanoparticles) to obtain a signal which is proportional to the concentration of particles in the region of low bias field. Here we extend previous models for estimating the energy dissipation rates of magnetic nanoparticles in uniform AMFs to provide theoretical predictions of how the selection magnetic field gradient used in MPI can be used to selectively actuate heating by magnetic nanoparticles in the low bias field region of the selection magnetic field gradient. Theoretical predictions are given for the spatial decay in energy dissipation rate under magnetic field gradients representative of those that can be achieved with current MPI technology. These results underscore the potential of combining MPI and higher amplitude/frequency actuation AMFs to achieve selective magnetic fluid hyperthermia (MFH) guided by MPI.

  14. Rectal cancer staging: focus on the prognostic significance of the findings described by high-resolution magnetic resonance imaging.

    Science.gov (United States)

    Dieguez, Adriana

    2013-07-22

    High-resolution (HR) magnetic resonance imaging (MRI) has become an indispensable tool for multidisciplinary teams (MDTs) addressing rectal cancer. It provides anatomic information for surgical planning and allows patients to be stratified into different groups according to the risk of local and distant recurrence. One of the objectives of the MDT is the preoperative identification of high-risk patients who will benefit from neoadjuvant treatment. For this reason, the correct evaluation of the circumferential resection margin (CRM), the depth of tumor spread beyond the muscularis propria, extramural vascular invasion and nodal status is of the utmost importance. Low rectal tumors represent a special challenge for the MDT, because decisions seek a balance between oncologic safety, in the pursuit of free resection margins, and the patient's quality of life, in order to preserve sphincter function. At present, the exchange of information between the different specialties involved in dealing with patients with rectal cancer can rank the contribution of colleagues, auditing their work and incorporating knowledge that will lead to a better understanding of the pathology. Thus, beyond the anatomic description of the images, the radiologist's role in the MDT makes it necessary to know the prognostic value of the findings that we describe, in terms of recurrence and survival, because these findings affect decision making and, therefore, the patients' life. In this review, the usefulness of HR MRI in the initial staging of rectal cancer and in the evaluation of neoadjuvant treatment, with a focus on the prognostic value of the findings, is described as well as the contribution of HR MRI in assessing patients with suspected or confirmed recurrence of rectal cancer.

  15. MultiFocus Polarization Microscope (MF-PolScope) for 3D polarization imaging of up to 25 focal planes simultaneously.

    Science.gov (United States)

    Abrahamsson, Sara; McQuilken, Molly; Mehta, Shalin B; Verma, Amitabh; Larsch, Johannes; Ilic, Rob; Heintzmann, Rainer; Bargmann, Cornelia I; Gladfelter, Amy S; Oldenbourg, Rudolf

    2015-03-23

    We have developed an imaging system for 3D time-lapse polarization microscopy of living biological samples. Polarization imaging reveals the position, alignment and orientation of submicroscopic features in label-free as well as fluorescently labeled specimens. Optical anisotropies are calculated from a series of images where the sample is illuminated by light of different polarization states. Due to the number of images necessary to collect both multiple polarization states and multiple focal planes, 3D polarization imaging is most often prohibitively slow. Our MF-PolScope system employs multifocus optics to form an instantaneous 3D image of up to 25 simultaneous focal-planes. We describe this optical system and show examples of 3D multi-focus polarization imaging of biological samples, including a protein assembly study in budding yeast cells.

  16. Numerical and experimental analysis of a point focus solar collector using high concentration imaging PMMA Fresnel lens

    Energy Technology Data Exchange (ETDEWEB)

    Xie, W.T. [Research Center of Solar Power and Refrigeration, Shanghai Jiao Tong University, Shanghai 200240 (China); Dai, Y.J., E-mail: yjdai@sjtu.edu.c [Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai 200240 (China); Wang, R.Z. [Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai 200240 (China)

    2011-06-15

    Research highlights: {yields} We studied a point focus Fresnel solar collector using different cavity receivers. {yields} The collector heat removal factors are derived to find the optimal cavity shape. {yields} Numerical and experimental analysis shows that the conical cavity is optimum. -- Abstract: A high concentration imaging Fresnel solar collector provided with different cavity receivers was developed and its behavior was investigated. Round copper pipes winded into different spring shapes were used as receiver by placing in the cylindrical cavity to absorb concentrated solar energy and transfer it to a heat transfer fluid (HTF). The collector efficiency factor and collector heat removal factor were derived for the cavity receivers to find out heat transfer mechanism and to propose an effective way for evaluating the performance of Fresnel solar collector and determining the optimal cavity structure. The problem of Fresnel solar collector with synthetic heat transfer oil flow was simulated and analyzed to investigate heat loss from different cavity receivers. Solar irradiation as well as convection and heat transfer in the circulating fluid and between the internal surfaces of the cavity and the environment are considered in the model. The temperature distribution over its area as well as the collector thermal efficiency at nominal flow rate was used in order to validate the simulation results. It was found that the simulated temperature distribution during operation and the average collector efficiency are in good agreement with the experimental data. Finally, the optimal shape of solar cavity receiver, as well as its thermal performance, are deeply analyzed and discussed.

  17. 基于图像处理的自动调焦技术研究%Study on Technology of Auto-focus Based on Image Processing

    Institute of Scientific and Technical Information of China (English)

    张晓娟

    2014-01-01

    随着自动调焦技术的快速发展,在成像系统中得到了广泛的应用。基于图像处理的自动调焦能够进一步满足各种成像设备的智能化自动调焦需求。基于图像处理的自动调焦的关键在于图像的清晰度评价函数,本文在对评价函数进行分析的基础上提出了梯度阈值评价函数,实现了调焦的实时性、抗噪性方面的提升。%With the rapid development of automatic focus technology, it has been widely used in the imaging system. Auto-focus technology based on image processing,which can further meet intelligent automatic focus needs of various imaging equipment.The key of Auto-focus technology based on image processing is the image clarity evaluation function. Based on the analysis of evaluation function we propose the gradient threshold evaluation function in this paper,which realized the real time and noise resistance of focusing improvements.

  18. Prasugrel vs clopidogrel in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction. Results of the ISAR-SHOCK registry.

    Science.gov (United States)

    Orban, M; Mayer, K; Morath, T; Bernlochner, I; Hadamitzky, M; Braun, S; Schulz, S; Hoppmann, P; Hausleiter, J; Tiroch, K; Mehilli, J; Schunkert, H; Massberg, S; Laugwitz, K-L; Sibbing, D; Kastrati, A

    2014-12-01

    There is limited clinical data comparing different P2Y12-receptor inhibitors in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock. The aim of the ISAR-SHOCK registry was to compare the clinical outcome of patients treated with clopidogrel vs prasugrel in this setting. Patients (n=145) with AMI complicated by cardiogenic shock and undergoing primary PCI in two centres (Deutsches Herzzentrum München and Klinikum rechts der Isar, Technical University Munich) between January 2009 and May 2012 were included in this registry. The use of prasugrel for patients within this registry reflected co-morbidities and platelet function testing results during the acute AMI phase. Early outcome at 30-days was reported with regard to all-cause mortality, myocardial infarction (MI), stent thrombosis (ST) and bleeding events. With regard to antiplatelet treatment in the 145 cardiogenic shock patients, 50 patients were initially treated or immediately switched to prasugrel while 95 patients were treated with clopidogrel. All-cause mortality was lower in prasugrel- vs clopidogrel-treated patients (30 % vs 50.5%, HR: 0.51, 95% CI [0.29-0.92], p=0.025). No significant differences in prasugrel- vs clopidogrel-treated patients were observed for the occurrence of MI (p=0.233), ST (p=0.306) or TIMI major bleedings (p=0.571). Results of the ISAR-SHOCK registry suggest that the use of prasugrel in AMI patients complicated by cardiogenic shock might be associated with a lower mortality risk as compared to clopidogrel therapy without increasing the risk of bleeding. These findings, however, need confirmation from specifically designed randomised studies in this high-risk cohort of patients.

  19. Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment

    Institute of Scientific and Technical Information of China (English)

    Maythem Saeed; Roland Krug; Loi Do; Steven W Hetts; Mark W Wilson

    2016-01-01

    AIM: To use magnetic resonance-guided high intensity focused ultrasound(MRg-HIFU), magnetic resonance imaging(MRI) and histopathology for noninvasively ablating, quantifying and characterizing ablated renal tissue. METHODS: Six anesthetized/mechanically-ventilated pigs underwent single/double renal sonication(n = 24) using a 3T-MRg-HIFU(1.1 MHz frequency and 3000J-4400 J energies). T2-weighted fast spin echo(T2-W), perfusion saturation recovery gradient echo and contrast enhanced(CE) T1-weighted(T1-W) sequences were used for treatment planning, temperature monitoring, lesion visualization, characterization and quantification, respectively. Histopathology was conducted in excised kidneys to quantify and characterize cellular and vascular changes. Paired Student’s t-test was used and a P-value < 0.05 was considered statistically significant.RESULTS: Ablated renal parenchyma could not be differentiated from normal parenchyma on T2-W or nonCE T1-W sequences. Ablated renal lesions were visible as hypoenhanced regions on perfusion and CE T1-W MRI sequences, suggesting perfusion deficits and necrosis. Volumes of ablated parenchyma on CE T1-W images invivo(0.12-0.36 cm3 for single sonication 3000 J, 0.50-0.84 cm3, for double 3000 J, 0.75-0.78 cm3 for single 4400 J and 0.12-2.65 cm3 for double 4400J) and at postmortem(0.23-0.52 cm3, 0.25-0.82 cm3, 0.45-0.68 cm3 and 0.29-1.80 cm3, respectively) were comparable. The ablated volumes on 3000 J and 4400 J double sonication were significantly larger than single(P < 0.01), thus, the volume and depth of ablated tissue depends on the applied energy and number of sonication. Macroscopic and microscopic examinations confirmed the locations and presence of coagulation necrosis, vascular damage and interstitial hemorrhage, respectively.CONCLUSION: Contrast enhanced MRI provides assessment of MRg-HIFU renal ablation. Histopathology demonstrated coagulation necrosis, vascular damage and confirmed the volume of damage seen on MRI.

  20. X-ray diffraction imaging of metal–oxide epitaxial tunnel junctions made by optical lithography: use of focused and unfocused X-ray beams

    Science.gov (United States)

    Mocuta, Cristian; Barbier, Antoine; Stanescu, Stefan; Matzen, Sylvia; Moussy, Jean-Baptiste; Ziegler, Eric

    2013-01-01

    X-ray diffraction techniques are used in imaging mode in order to characterize micrometre-sized objects. The samples used as models are metal–oxide tunnel junctions made by optical lithography, with lateral sizes ranging from 150 µm down to 10 µm and various shapes: discs, squares and rectangles. Two approaches are described and compared, both using diffraction contrast: full-field imaging (topography) and raster imaging (scanning probe) using a micrometre-sized focused X-ray beam. It is shown that the full-field image gives access to macroscopic distortions (e.g. sample bending), while the local distortions, at the micrometre scale (e.g. tilts of the crystalline planes in the vicinity of the junction edges), can be accurately characterized only using focused X-ray beams. These local defects are dependent on the junction shape and larger by one order of magnitude than the macroscopic curvature of the sample. PMID:23412494

  1. Report of the first prototype of non-imaging focusing heliostat and its application in high temperature solar furnace

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.T.; Ismail, Ghazally [Malaysia Univ. of Science and Technology, Inst. of Energy and Environment, Selangor (Malaysia); Chong, K.K.; Lim, C.S.; Lim, B.H.; Tan, B.K. [Malaysia Univ. of Science and Technology, Inst. of Energy and Environment, Selangor (Malaysia); Univ. of Technology Malaysia, Faculty of Electrical Engineering, Johor (Malaysia); Tan, K.K.; Aliman, Omar; Bligh, T.P. [Univ. of Technology Malaysia, Faculty of Electrical Engineering, Johor (Malaysia)

    2002-06-01

    Following the publication on the principle and theory of a newly proposed non-imaging focusing heliostat, this paper presents a report on the design, optical alignment and application of the first prototype heliostat. In the architecture of the first prototype, 25 mirrors, each with a dimension of 40x40 cm, are arranged into five rows and five columns to form a total reflective area of 4 m{sup 2}. The design of the essential part of the first prototype heliostat will be discussed in this paper, which consists of two primary elements; a rotation-elevation system for tracking a mirror support frame which carries 25 mirror facets, and a separate two-axis tracking system for compensating (each second) off-axis aberrations of 24 slave facets relative to the central mirror, which is fixed in the mirror frame. The rotation-elevation system consists of a pedestal supporting a rotational tracking mechanism carrying a U-shaped arm and a second tracking system for tracking a moving frame in elevation. The moving frame carries a central stationary (relative to the frame) mirror, called a master mirror. Slave mirrors are arrayed in five rows and five columns, and eight stepper motors drive the outer four rows and columns relative to the master mirror via a computer programme implementing newly proposed formulas to eliminate the first-order aberration. With a second stage concentrator comprising a small aperture size parabolic mirror (diameter of 60 cm), a cost-effective high temperature solar furnace was constructed. In our experiment, the highest furnace temperature of 3400 deg C has been recorded through the melting of pure tungsten wires. (Author)

  2. Selecting suitable coherent processing time window lengths for ground-based ISAR imaging of cooperative sea vessels

    CSIR Research Space (South Africa)

    Abdul Gaffar, MY

    2009-09-01

    Full Text Available ) where mod(a, b) is the modulus operation of a with b, θb,t(n) denotes the bearing of the vessel obtained from GPS position data, and θh,t(n) represents the heading measured from an inertial navigation system. The head- ing that is used in the system...

  3. Paramagnetic perfluorocarbon-filled albumin-(Gd-DTPA) microbubbles for the induction of focused-ultrasound-induced blood-brain barrier opening and concurrent MR and ultrasound imaging

    Science.gov (United States)

    Liao, Ai-Ho; Liu, Hao-Li; Su, Chia-Hao; Hua, Mu-Yi; Yang, Hung-Wei; Weng, Yu-Ting; Hsu, Po-Hung; Huang, Sheng-Min; Wu, Shih-Yen; Wang, Hsin-Ell; Yen, Tzu-Chen; Li, Pai-Chi

    2012-05-01

    This paper presents new albumin-shelled Gd-DTPA microbubbles (MBs) that can concurrently serve as a dual-modality contrast agent for ultrasound (US) imaging and magnetic resonance (MR) imaging to assist blood-brain barrier (BBB) opening and detect intracerebral hemorrhage (ICH) during focused ultrasound brain drug delivery. Perfluorocarbon-filled albumin-(Gd-DTPA) MBs were prepared with a mean diameter of 2320 nm and concentration of 2.903×109 MBs ml-1 using albumin-(Gd-DTPA) and by sonication with perfluorocarbon (C3F8) gas. The albumin-(Gd-DTPA) MBs were then centrifuged and the procedure was repeated until the free Gd3+ ions were eliminated (which were detected by the xylenol orange sodium salt solution). The albumin-(Gd-DTPA) MBs were also characterized and evaluated both in vitro and in vivo by US and MR imaging. Focused US was used with the albumin-(Gd-DTPA) MBs to induce disruption of the BBB in 18 rats. BBB disruption was confirmed with contrast-enhanced T1-weighted turbo-spin-echo sequence MR imaging. Heavy T2*-weighted 3D fast low-angle shot sequence MR imaging was used to detect ICH. In vitro US imaging experiments showed that albumin-(Gd-DTPA) MBs can significantly enhance the US contrast in T1-, T2- and T2*-weighted MR images. The r1 and r2 relaxivities for Gd-DTPA were 7.69 and 21.35 s-1mM-1, respectively, indicating that the MBs represent a positive contrast agent in T1-weighted images. In vivo MR imaging experiments on 18 rats showed that focused US combined with albumin-(Gd-DTPA) MBs can be used to both induce disruption of the BBB and detect ICH. To compare the signal intensity change between pure BBB opening and BBB opening accompanying ICH, albumin-(Gd-DTPA) MB imaging can provide a ratio of 5.14 with significant difference (p = 0.026), whereas Gd-DTPA imaging only provides a ratio of 2.13 and without significant difference (p = 0.108). The results indicate that albumin-(Gd-DTPA) MBs have potential as a US/MR dual-modality contrast agent for

  4. Beam Halo formation and loss induced by image-charge effects in a small-aperture alternating-gradient focusing system

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, J.; Qian, B.L.; Chen, C.; Henestroza, E.; Eylon, S.; Yu S.

    2003-05-01

    Effects of image charges on beam halo formation and beam loss in small-aperture alternating-gradient focusing systems are studied analytically, computationally, and experimentally. Nonlinear image-charge fields result in chaotic particle motion and the ejection of particles from the beam core into a halo. Detailed chaotic particle motion and structure of the particle phase space is studied, and the beam loss rate is computed for a long transport channel. Image-charge effects are also studied for a short transport channel, and compared with the Neutralized Transport Experiment (NTX) at LBNL.

  5. [Imaging of the elbow joint with focused MRI. Part 1: examination techniques and sequences for bone and ligaments].

    Science.gov (United States)

    Rehm, J; Zeifang, F; Weber, M-A

    2014-02-01

    Imaging of the elbow joint places high demands on the quality of imaging due to the challenging anatomy and the sometimes subtle findings. For the diagnosis of periarticular soft tissues, ligamentous structures and in individual cases for fracture and tumor diagnosis, magnetic resonance imaging (MRI) is mostly groundbreaking and allows a reliable diagnosis in most cases. This review article discusses the complex imaging anatomy and anatomical variants of this joint and the most common osseous and ligamentous injuries of the elbow joint are presented. The typical MRI findings and indications are illustrated and discussed and possible pitfalls are pointed out. The various examination techniques and MRI sequences are also addressed.

  6. A pilot study investigating whether focusing on body functionality can protect women from the potential negative effects of viewing thin-ideal media images

    NARCIS (Netherlands)

    Alleva, J.M.; Veldhuis, J.; Martijn, C.

    2016-01-01

    This pilot study explored whether focusing on body functionality (i.e., everything the body can do) can protect women from potential harmful effects of exposure to thin-ideal images. Seventy women (Mage=20.61) completed an assignment wherein they either described the functionality of their body or t

  7. Improving the Confidence of Pre-Adolescent Girls by Focusing on the Development of Positive Self-Esteem, Body Image, and Assertiveness Skills.

    Science.gov (United States)

    Combes, Alice S.

    This practicum was designed to focus on: (1) the improvement of the confidence of pre-adolescent girls; (2) the establishment of a positive body image; and (3) the strengthening of assertiveness skills. The writer worked in a group of 20 girls over a period of 8 months using exercises designed to facilitate their growth. A curriculum was developed…

  8. A pilot study investigating whether focusing on body functionality can protect women from the potential negative effects of viewing thin-ideal media images.

    Science.gov (United States)

    Alleva, Jessica M; Veldhuis, Jolanda; Martijn, Carolien

    2016-06-01

    This pilot study explored whether focusing on body functionality (i.e., everything the body can do) can protect women from potential harmful effects of exposure to thin-ideal images. Seventy women (Mage=20.61) completed an assignment wherein they either described the functionality of their body or the routes that they often travel (control). Afterward, participants were exposed to a series of thin-ideal images. Appearance and functionality satisfaction were measured before the assignment; appearance and functionality satisfaction, self-objectification, and body appreciation were measured after exposure. Results showed that participants who focused on body functionality experienced greater functionality satisfaction and body appreciation compared to control participants. Therefore, focusing on body functionality could be a beneficial individual-level technique that women can use to protect and promote a positive body image in the face of thin-ideal images. Research including a condition wherein participants are exposed to (product-only) control images is necessary to draw firmer conclusions.

  9. Analysis of the IMAGE RPI electron density data and CHAMP plasmasphere electron density reconstructions with focus on plasmasphere modelling

    Science.gov (United States)

    Gerzen, T.; Feltens, J.; Jakowski, N.; Galkin, I.; Reinisch, B.; Zandbergen, R.

    2016-09-01

    The electron density of the topside ionosphere and the plasmasphere contributes essentially to the overall Total Electron Content (TEC) budget affecting Global Navigation Satellite Systems (GNSS) signals. The plasmasphere can cause half or even more of the GNSS range error budget due to ionospheric propagation errors. This paper presents a comparative study of different plasmasphere and topside ionosphere data aiming at establishing an appropriate database for plasmasphere modelling. We analyze electron density profiles along the geomagnetic field lines derived from the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) satellite/Radio Plasma Imager (RPI) records of remote plasma sounding with radio waves. We compare these RPI profiles with 2D reconstructions of the topside ionosphere and plasmasphere electron density derived from GNSS based TEC measurements onboard the Challenging Minisatellite Payload (CHAMP) satellite. Most of the coincidences between IMAGE profiles and CHAMP reconstructions are detected in the region with L-shell between 2 and 5. In general the CHAMP reconstructed electron densities are below the IMAGE profile densities, with median of the CHAMP minus IMAGE residuals around -588 cm-3. Additionally, a comparison is made with electron densities derived from passive radio wave RPI measurements onboard the IMAGE satellite. Over the available 2001-2005 period of IMAGE measurements, the considered combined data from the active and passive RPI operations cover the region within a latitude range of ±60°N, all longitudes, and an L-shell ranging from 1.2 to 15. In the coincidence regions (mainly 2 ⩽ L ⩽ 4), we check the agreement between available active and passive RPI data. The comparison shows that the measurements are well correlated, with a median residual of ∼52 cm-3. The RMS and STD values of the relative residuals are around 22% and 21% respectively. In summary, the results encourage the application of IMAGE RPI data for

  10. A Secondary Focusing Algorithm Based On Image Processing%一种基于图像处理的二次聚焦算法

    Institute of Scientific and Technical Information of China (English)

    谷元保; 肖加俊

    2016-01-01

    How to quickly and accurately realize the focusing is always the main researching content of the auto-focus-ing technology. The key step of the focusing algorithm is to select the correct evaluation function. The traditional focus-ing evaluation function has some problems in the application,especially in deep defocus conditions. In the depth of de-focus condition, the following defects are encountered:focusing failure, inaccuracy focusing in effective region and so on. To solve these problems, an improved focusing algorithm, a secondary focusing based on image processing, is in-troduced based on the existing focusing algorithm. The improved focusing algorithm can achieve stability, rapidity and accuracy of auto-focusing easily. The first focusing uses improved automatic threshold algorithm of variance function to complete the fast focusing with selecting parts of image data in the center area. The second focus selects the first part of inverted T shaped area image data, using the form of Robert gradient threshold to get precise focusing.The testing results show that the improved secondary auto-focusing algorithm has some advantages in terms of stability, speed and accuracy of focusing,especially the focusing effect is more significant when it’s in the depth of defocus.%如何快速、准确地实现聚焦一直是自动聚焦技术的主要研究内容,其中关键问题是选取正确的评价函数。传统聚焦评价函数在应用于深度离焦情况时存在一些诸如聚焦失败、有效聚焦区域内精度不够等问题。针对这些问题,为了提高自动聚焦的稳定性、快速性、准确性,阐述了一种在现有聚焦算法的基础上改进的基于图像处理的二次聚焦的算法。第一次聚焦选取中心范围内部分区域的图像数据,采用改进的自动阈值方差函数算法来完成快速聚焦。第二次聚焦选取包含第一部分的倒T字形区域图像数据,采用Robert梯度-阈值形式进行

  11. An auto-tuning method for focusing and astigmatism correction in HAADF-STEM, based on the image contrast transfer function.

    Science.gov (United States)

    Baba, N; Terayama, K; Yoshimizu, T; Ichise, N; Tanaka, N

    2001-01-01

    An auto-tuning method for high-angle annular detector dark field scanning transmission electron microscopy (HAADF-STEM) is proposed which corrects the defocus to the optimum Scherzer focus and compensates the astigmatism. Because the method is based on the image contrast transfer function formulated for the HAADF-STEM, the defocus and the astigmatism are accurately measured from input of two different defocus images. The method is designed to work independent of object function in the linear imaging model by analysing the spectral ratio between two Fourier spectra of their images, which is useful for cases where the spectrum of object function is not uniformly spread out over the reciprocal space. The method was preliminarily tested in a Hitachi HD-2000 STEM, and successful results of the auto-tunings from the viewpoint of verification of the algorithm were obtained using general specimens of Au fine particles and a thin section of a semiconductor device.

  12. Which is the best advanced MR imaging protocol for predicting recurrent metastatic brain tumor following gamma-knife radiosurgery: focused on perfusion method

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Myeong Ju; Kim, Ho Sung; Choi, Choong Gon; Kim, Sang Joon [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Songpa-Gu, Seoul (Korea, Republic of)

    2015-04-01

    High spatial resolution of dynamic contrast-enhanced (DCE) MR imaging allows characterization of heterogenous tumor microenvironment. Our purpose was to determine which is the best advanced MR imaging protocol, focused on additional MR perfusion method, for predicting recurrent metastatic brain tumor following gamma-knife radiosurgery (GKRS). Seventy-two consecutive patients with post-GKRS metastatic brain tumor were enrolled. Two readers independently calculated the percentile histogram cutoffs for normalized cerebral blood volume (nCBV) from dynamic susceptibility contrast (DSC) imaging and initial area under the time signal-intensity curve (IAUC) from DCE imaging, respectively. Area under the receiver operating characteristic curve (AUC) and interreader agreement were assessed. For differentiating tumor recurrence from therapy effect, adding DCE imaging to diffusion-weighted imaging (DWI) significantly improved AUC from 0.79 to 0.95 for reader 1 and from 0.80 to 0.96 for reader 2, respectively. There was no significant difference of AUC between the combination of DWI with DSC imaging and the combination of DWI with DCE imaging for both readers. With the combination of DWI and DCE imaging, the sensitivity and specificity were 86.7 and 88.1 % for reader 1 and 90.0 and 85.7 % for reader 2, respectively. The intraclass correlation coefficient (ICC) between readers was highest for calculation of the 90th percentile histogram cutoffs for IAUC (ICC, 0.87). Adding perfusion MR imaging to DWI significantly improves the prediction of recurrent metastatic tumor; however, the diagnostic performance is not affected by selection of either DSC or DCE MR perfusion method. (orig.)

  13. Expand Your Horizon: A programme that improves body image and reduces self-objectification by training women to focus on body functionality.

    Science.gov (United States)

    Alleva, Jessica M; Martijn, Carolien; Van Breukelen, Gerard J P; Jansen, Anita; Karos, Kai

    2015-09-01

    This study tested Expand Your Horizon, a programme designed to improve body image by training women to focus on the functionality of their body using structured writing assignments. Eighty-one women (Mage=22.77) with a negative body image were randomised to the Expand Your Horizon programme or to an active control programme. Appearance satisfaction, functionality satisfaction, body appreciation, and self-objectification were measured at pretest, posttest, and one-week follow-up. Following the intervention, participants in the Expand Your Horizon programme experienced greater appearance satisfaction, functionality satisfaction, and body appreciation, and lower levels of self-objectification, compared to participants in the control programme. Partial eta-squared effect sizes were of small to medium magnitude. This study is the first to show that focusing on body functionality can improve body image and reduce self-objectification in women with a negative body image. These findings provide support for addressing body functionality in programmes designed to improve body image. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion)

    NARCIS (Netherlands)

    Kuniyil Ajith Singh, M.; Jaeger, M.; Frenz, M.; Steenbergen, W.

    2016-01-01

    Reflection artifacts caused by acoustic inhomogeneities are a critical problem in epi-mode biomedical photoacoustic imaging. High light fluence beneath the probe results in photoacoustic transients, which propagate into the tissue and reflect back from echogenic structures. These reflection artifact

  15. Analysis of image quality according to BMI of digital chest radiography: Focusing on bureau of radiological health evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Seong Jin [Gammaknife center, Inje University Haeundae Paik Hospital, Busan (Korea, Republic of); Im, In Chul [Dept. of Radiological Science, Dongeui University, Busan (Korea, Republic of); Cho, Ji Hwan [Dept. of Health Care Clinic, Inje University Busan Paik Hospital, Busan (Korea, Republic of)

    2017-03-15

    Visual evaluation of chest radiograph images is the most practical and effective method. This study compared the Body Mass Index, waist circumference, and mAs with chest radiographs of 351 women. The Bureau of Radiological Health method was used to evaluate the image quality of chest X-ray images by anatomical and physical methods. The average age of the subjects was 30.17±4.73 and the average waist circumference was 66.91±4.67 cm. The mean Body Mass Index value was 20.21±2.23, the mean value of mAs was 3.04±0.78, and the mean value of Bureau of Radiological Health was 79.83±8.45. When the Body Mass Index value increased, waist circumference and mAs mean value increased. The mean value of Body Mass Index was statistically significant(p<0.05) in Group 4 compared to Groups 1 and 2, with increasing Body Mass Index. Exposure control of the automatic exposure control system is considered to be well performed according to body thickness or Body Mass Index at the time of chest radiography. As the Body Mass Index increases, the thickness of the body increases and the breast thickness of the woman also increases. Therefore, it is considered that the exposure amount is changed by the automatic exposure control device to affect the image quality.

  16. MO-AB-210-00: Diagnostic Ultrasound Imaging Quality Control and High Intensity Focused Ultrasound Therapy Hands-On Workshop

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-06-15

    The goal of this ultrasound hands-on workshop is to demonstrate advancements in high intensity focused ultrasound (HIFU) and to demonstrate quality control (QC) testing in diagnostic ultrasound. HIFU is a therapeutic modality that uses ultrasound waves as carriers of energy. HIFU is used to focus a beam of ultrasound energy into a small volume at specific target locations within the body. The focused beam causes localized high temperatures and produces a well-defined regions of necrosis. This completely non-invasive technology has great potential for tumor ablation and targeted drug delivery. At the workshop, attendees will see configurations, applications, and hands-on demonstrations with on-site instructors at separate stations. The involvement of medical physicists in diagnostic ultrasound imaging service is increasing due to QC and accreditation requirements. At the workshop, an array of ultrasound testing phantoms and ultrasound scanners will be provided for attendees to learn diagnostic ultrasound QC in a hands-on environment with live demonstrations of the techniques. Target audience: Medical physicists and other medical professionals in diagnostic imaging and radiation oncology with interest in high-intensity focused ultrasound and in diagnostic ultrasound QC. Learning Objectives: Learn ultrasound physics and safety for HIFU applications through live demonstrations Get an overview of the state-of-the art in HIFU technologies and equipment Gain familiarity with common elements of a quality control program for diagnostic ultrasound imaging Identify QC tools available for testing diagnostic ultrasound systems and learn how to use these tools List of supporting vendors for HIFU and diagnostic ultrasound QC hands-on workshop: Philips Healthcare Alpinion Medical Systems Verasonics, Inc Zonare Medical Systems, Inc Computerized Imaging Reference Systems (CIRS), Inc. GAMMEX, Inc., Cablon Medical BV Steffen Sammet: NIH/NCI grant 5R25CA132822, NIH/NINDS grant 5R25NS

  17. Side-by-side comparison of disposable microchips with commercial capillary cartridges for application in capillary isoelectric focusing with whole column imaging detection.

    Science.gov (United States)

    Liu, Zhen; Ou, Junjie; Samy, Razim; Glawdel, Tomasz; Huang, Tiemin; Ren, Carolyn L; Pawliszyn, Janusz

    2008-10-01

    Simple-structured, well-functioned disposable poly(dimethylsiloxane) (PDMS) microchips were developed for capillary isoelectric focusing with whole column imaging detection (CIEF-WCID). Side-by-side comparison of the developed microchips with well-established commercial capillary cartridges demonstrated that the disposable microchips have comparable performance as well as advantages such as absence of lens effect and possibility of high-aspect-ratio accompanied with a dramatic reduction in cost.

  18. Positioning the image of Mexico in the media of english-speaking nations of the Pacific rim: with focus on the USA, Canada and New Zealand

    Directory of Open Access Journals (Sweden)

    Andrii Ryzhkov

    2016-02-01

    Full Text Available This paper examines the overall image of Mexico promoted through its foreign policy (Nation Branding strategies and reflected in the Us, Canadian, and New Zealand press, with a focus on two major newspapers in each country. To do this, this article employs both quantitative and qualitative analysis. It offers a 6-month long diagnosis of news (1st November, 2014 ~ 30th April, 2015, which will disclose the agenda of objects and attributes regarding Mexico.

  19. Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: an in vivo feasibility study in a transgenic mouse model of pancreatic cancer.

    Science.gov (United States)

    Chen, Hong; Hou, Gary Y; Han, Yang; Payen, Thomas; Palermo, Carmine F; Olive, Kenneth P; Konofagou, Elisa E

    2015-09-01

    Harmonic motion imaging (HMI) is a radiationforce- based elasticity imaging technique that tracks oscillatory tissue displacements induced by sinusoidal ultrasonic radiation force to assess the resulting oscillatory displacement denoting the underlying tissue stiffness. The objective of this study was to evaluate the feasibility of HMI in pancreatic tumor detection and high-intensity focused ultrasound (HIFU) treatment monitoring. The HMI system consisted of a focused ultrasound transducer, which generated sinusoidal radiation force to induce oscillatory tissue motion at 50 Hz, and a diagnostic ultrasound transducer, which detected the axial tissue displacements based on acquired radio-frequency signals using a 1-D cross-correlation algorithm. For pancreatic tumor detection, HMI images were generated for pancreatic tumors in transgenic mice and normal pancreases in wild-type mice. The obtained HMI images showed a high contrast between normal and malignant pancreases with an average peak-to-peak HMI displacement ratio of 3.2. Histological analysis showed that no tissue damage was associated with HMI when it was used for the sole purpose of elasticity imaging. For pancreatic tumor ablation monitoring, the focused ultrasound transducer was operated at a higher acoustic power and longer pulse length than that used in tumor detection to simultaneously induce HIFU thermal ablation and oscillatory tissue displacements, allowing HMI monitoring without interrupting tumor ablation. HMI monitoring of HIFU ablation found significant decreases in the peak-to-peak HMI displacements before and after HIFU ablation with a reduction rate ranging from 15.8% to 57.0%. The formation of thermal lesions after HIFU exposure was confirmed by histological analysis. This study demonstrated the feasibility of HMI in abdominal tumor detection and HIFU ablation monitoring.

  20. Survey of the auto-focus methods based on image processing%基于图像处理的自动对焦技术综述

    Institute of Scientific and Technical Information of China (English)

    尤玉虎; 刘通; 刘佳文

    2013-01-01

    简述了传统和现代自动对焦技术方法并进行对比,在此基础上详细介绍了基于图像处理的自动对焦技术的原理和核心问题,提出了该技术中的关键技术是图像清晰度评价方法和搜索算法并对具体技术进行了描述.%Based on brief review and comparison between the traditional and the modern auto-focus methods, the theory and the key points of the auto-focus method based on image processing are put forward. It is figured out that the image-clarity evaluation and searching algorithm are key technologies in the study of auto-focus method based on image processing. And the approaches of these aspects are described in detail.

  1. Design and construction of a micro-focus in-line phase-contrast cone-beam CT (PC-CBCT) system for soft tissue imaging

    Science.gov (United States)

    Cai, Weixing; Ning, Ruola

    2010-04-01

    In recent years, the in-line phase-contrast (in-line PC) technique has been implemented using synchrotrons and microfocus x-ray tubes for soft tissue imaging as the in-line PC's image quality enhancement. In this study, a new in-line phase-contrast cone-beam CT (PC-CBCT) system has been designed and tested in our lab to produce higher image quality enhancement. The PC-CBCT system consists of a micro-focus x-ray tube, a high-resolution detector and a rotating phantom holder. The nominal focal spot size is 9 microns, which is expected to produce partially coherent x-rays. The detector system has a phosphor screen, an optical fiber coupling unit and a CMOS chip with an effective pixel pitch of 22.5 microns. Some key system parameters, including tube voltage (or x-ray spectrum), source-to-object distance and object-to-detector distance were balanced and optimized to achieve enough spatial coherence and degree of interference to acquire edge-enhanced phase-contrast images as projection images. The phantom holder was rotated for 360 degrees with a step of 1.2 degrees, and during the rotation in-line PC images were acquired at all angular positions. The FDK algorithm was applied to compute the reconstruction using the edge-enhanced PC images. Small soft tissue samples (breast tissues and animal organs) were scanned and reconstructed. The tomographic images showed enhanced structure edges and details.

  2. Algebraic and numerical analysis of imaging properties of thin tunable-focus fluidic membrane lenses with parabolic surfaces.

    Science.gov (United States)

    Miks, Antonin; Novak, Jiri; Novak, Pavel

    2013-04-01

    The theory of third-order aberrations for a system of rotationally symmetric thin tunable-focus fluidic membrane lenses with parabolic surfaces is described. A complex analysis of the third-order design of tunable fluidic lenses is performed considering all types of primary aberrations. Moreover, formulas are derived for the calculation of the change of aberration coefficients of the parabolic tunable fluidic membrane lens with respect to the wavelength. It is shown that spherical aberration of a simple tunable-focus fluidic membrane lens with parabolic surfaces can be corrected, which is not possible with a classical spherical lens. The presented analysis is explained on examples. Derived formulas make possible to calculate parameters of optical systems with fluidic membrane lenses with small residual aberrations.

  3. Differentiation between tuberculous and pyogenic spondylitis on Gd-enhanced MR imaging : focus on the patterns of disc enhancement

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Seung Bae; Shin, Young Yeol; Lee, Sang Yong; Lee, Jeong Min; Han, Young Min; Chung, Gyung Ho; Kim, Chong Soo [Chonbuk National Univ. Hospital, Chonju (Korea, Republic of)

    2001-09-01

    The purpose of this study was to analyze the patterns of intervertebral disc enhancement seen in tuberculous and pyogenic spondylitis, and to evaluate their utility in differentiating between the two groups. Magnetic resonance images obtained in 31 consecutive infectious spondylitis patients (43 discs) in whom intervention occurred due to infected vertebral bodies, were retrospectively analysed. Nineteen of the patients had tuberculosis and 12 were infected by pyogenic organisms. After analysis, the patterns of disc enhancement revealed by contrast-enhanced T1-weighted axial and sagittal MR imaging were classified as of four types : Type I, non-enhancing; Type II, enhancement of the peripheral margin of the disc; Type III, enhancement of the peripheral margin and central area adjacent to the cortical vertebral endplate; Type IV, general enhancement and/or destruction of the disc. There were 19 cases of tuberculous spondylitis involving 28 intervertebral discs, and the enhancement patterns observed were as follows : Type I : n=4, 14%, Type II : n-17, 61%, Type III : n=1, 4%, Type IV : n=6, 21%. Twelve cases of pyogenic spondylitis involved 15 intervertebral discs ; the enhancement patterns observed in these cases were as follows : Type I : n=1, 7%, Type II : n=2, 13%, Type III : n=10, 67%, Type IV : n=2 13%. Careful analysis of the patterns of disc enhancement occurring in infectious spondylitis can be useful for differentiating between the tuberculous and pyogenic varieties of this condition.

  4. Image shutters: Gated proximity-focused Microchannel Plate (MCP) wafer tubes versus gated Silicon Intensified Target (SIT) vidicons

    Science.gov (United States)

    Yates, G. J.; King, N. S. P.; Jaramillo, S. A.; Ogle, J. W.; Noel, B. W.; Thayer, N. N.

    Response data, including gating speed, gain, dynamic range, shuttering efficiency, and resolution for 18- and 25-mm-diam proximity-focused microchannel-plate (MCP) intensifiers are compared with similar data for a prototype electrostatically-focused 25-mm-diam gated silicon-intensified-target (SIT) vidicon. Conductive substrate material and thickness used to reduce photocathode resistivity, spacing between gating electrodes to minimize inter-electrode capacitance, the use of conductive grids on the photocathode substrate to permit rapid propagation of the electrical gate pulse to all areas of the photocathode, and different package geometries to provide a more effective interface with external biasing and gating circuitry were varied in both tube types to determine optimal performance from each design. For comparable spatial resolution, most 18-mm-diam MCPs require gate times 2.5 ns while the fastest SIT has demonstrated sub-nanosecond optical gates as short as approximately 400 + or - 50 ps for full shuttering of the 25-mm-diam input window.

  5. FocusStack and StimServer: A new open source MATLAB toolchain for visual stimulation and analysis of two-photon calcium neuronal imaging data

    Directory of Open Access Journals (Sweden)

    Dylan Richard Muir

    2015-01-01

    Full Text Available Two-photon calcium imaging of neuronal responses is an increasingly accessible technology for probing population responses in cortex at single cell resolution, and with reasonable and improving temporal resolution. However, analysis of two-photon data is usually performed using ad-hoc solutions. To date, no publicly available software exists for straightforward analysis of stimulus-triggered two-photon imaging experiments. In addition, the increasing data rates of two-photon acquisition systems imply increasing cost of computing hardware required for in-memory analysis. Here we present a Matlab toolbox, FocusStack, for simple and efficient analysis of two-photon calcium imaging stacks on consumer-level hardware, with minimal memory footprint. We also present a Matlab toolbox, StimServer, for generation and sequencing of visual stimuli, designed to be triggered over a network link from a two-photon acquisition system. FocusStack is compatible out of the box with several existing two-photon acquisition systems, and is simple to adapt to arbitrary binary file formats. Analysis tools such as stack alignment for movement correction, automated cell detection and peri-stimulus time histograms are already provided, and further tools can be easily incorporated. Both packages are available as publicly-accessible source-code repositories.

  6. FocusStack and StimServer: a new open source MATLAB toolchain for visual stimulation and analysis of two-photon calcium neuronal imaging data.

    Science.gov (United States)

    Muir, Dylan R; Kampa, Björn M

    2014-01-01

    Two-photon calcium imaging of neuronal responses is an increasingly accessible technology for probing population responses in cortex at single cell resolution, and with reasonable and improving temporal resolution. However, analysis of two-photon data is usually performed using ad-hoc solutions. To date, no publicly available software exists for straightforward analysis of stimulus-triggered two-photon imaging experiments. In addition, the increasing data rates of two-photon acquisition systems imply increasing cost of computing hardware required for in-memory analysis. Here we present a Matlab toolbox, FocusStack, for simple and efficient analysis of two-photon calcium imaging stacks on consumer-level hardware, with minimal memory footprint. We also present a Matlab toolbox, StimServer, for generation and sequencing of visual stimuli, designed to be triggered over a network link from a two-photon acquisition system. FocusStack is compatible out of the box with several existing two-photon acquisition systems, and is simple to adapt to arbitrary binary file formats. Analysis tools such as stack alignment for movement correction, automated cell detection and peri-stimulus time histograms are already provided, and further tools can be easily incorporated. Both packages are available as publicly-accessible source-code repositories.

  7. Clinical significance of hypoxia in nasopharyngeal carcinoma with a focus on existing and novel hypoxia molecular imaging.

    Science.gov (United States)

    Yip, Connie; Cook, Gary J R; Wee, Joseph; Fong, Kam Weng; Tan, Terence; Goh, Vicky

    2016-04-01

    Locally advanced nasopharyngeal carcinoma (NPC) is still associated with significant locoregional failure and poor overall survival (OS) after chemoradiation. The maximal therapeutic effect of conventional chemotherapy combined with radiation may have been reached and there is a clinical need to identify additional adverse prognostic factors that could be targeted therapeutically. Hypoxia, a known prognostic factor in head and neck cancers is an attractive target in NPC with various treatment strategies available such as hypoxic cell sensitisers/cytotoxins and increasing intratumoral oxygen delivery, to overcome the poorer outcomes associated with this phenotype. Thus, we aim to review the clinical significance of hypoxia as well as the current and future of molecular hypoxia imaging in NPC.

  8. Understanding the role of gender in body image research settings: participant gender preferences for researchers and co-participants in interviews, focus groups and interventions.

    Science.gov (United States)

    Yager, Zali; Diedrichs, Phillippa C; Drummond, Murray

    2013-09-01

    Participant gender preferences for body image researchers, interventionists and focus group and intervention co-participants have been largely ignored, despite recognition that such characteristics can influence the nature and quality of data collected and intervention effects. To address this, Australian women (n=505) and men (n=220) completed a questionnaire about their preferences for interviewers and focus group facilitators, for teachers delivering school-based interventions, and for co-participants in these settings. Women predominantly preferred female interviewers and teachers, and mixed-sex co-participants, but most had no preference for focus group facilitators. Body dissatisfied women were more likely to prefer female researchers and single-sex co-participants. Most men did not have specific preferences, however, body dissatisfied men were more likely to report a gender preference for interviewers and teachers. Professional capabilities, personal qualities and appearance were regarded as important researcher characteristics. These findings have important implications for body image research, particularly among high-risk groups.

  9. Reproducibility and interobserver agreement of the R.E.N.A.L. nephrometry score: focus on imaging features

    Science.gov (United States)

    Vilaseca, Richard Mast; Westphalen, Antonio Carlos; Reis, Henrique Ferreira; Zogbi, Orlando Salomão; Silva, Gyl Eanes; dos Reis, Rodolfo Borges; Muglia, Valdair Francisco

    2017-01-01

    Objective To investigate the reproducibility and interobserver agreement for R.E.N.A.L. nephrometry scoring system. Materials and Methods Two independent radiologists retrospectively analyzed 46 consecutive patients with renal masses, between 2008 and 2012, using the R.E.N.A.L. nephrometry score (RENAL-NS), which is based on the evaluation of five anatomical features of the tumor, as evaluated with computed tomography or magnetic resonance imaging: Radius, Exophytic/endophytic properties, Nearness to the collecting system, Anterior or posterior descriptor, and Location relative to the polar line. Tumor complexity was graded as low, intermediate, or high. The interobserver agreement was calculated for the total score and for the score for each parameter. Surgical excision of the tumors was used as the standard of reference. Results The interobserver agreement for each of the RENAL-NS parameters, respectively, a hilar location, and the total score was 98%, 80%, 100%, 89%, 85%, 89%, and 93% of patients, corresponding to kappa values of 0.96, 0.65, 1.00, 0.75, 0.72, 0.78, and 0.88, respectively. The Nearness, Radius, and total score showed the best agreement. For the cases that were discordant in terms of the final score, no major implications in surgical planning were observed. Conclusion The RENAL-NS is a structured, useful system to assess the anatomical features of renal tumors. It is easily applicable and reproducible, even for less experienced radiologists. PMID:28298726

  10. An ASIC design for versatile receive front-end electronics of an ultrasonic medical imaging system--16 channel analog inputs and 4 dynamically focused beam outputs.

    Science.gov (United States)

    Park, Song B; Kwak, Jaeyoung; Lee, Kwyro

    2003-04-01

    An ultra large-scale ASIC is designed for the receive front-end electronics of an ultrasonic medical imaging system. The chip receives 16 channel analog rf signals and outputs 4 sets of sample-point-wise dynamically focused partial beam data. Four complete beam data sets are obtained in parallel by simply cascading as many chips as needed in an array system. High resolution of the focusing delay is obtained by nonuniformly selecting each channel data from a quadruply-interpolated rf data stream. The proposed ASIC can be applied to most practical array transducers in the frequency range of 2 to 10 MHz. The digital part of the designed ASIC can be implemented on a chip area of 17.9 microm2 with 0.18 mm CMOS technology, leaving sufficient room for 16 ADCs of 8 bits, 50 MHz on the 5.7 mm x 5.7 mm chip with a 208 pin package.

  11. Low-intensity focused ultrasound (LIFU-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging

    Directory of Open Access Journals (Sweden)

    Liu J

    2017-01-01

    Full Text Available Jianxin Liu,1,* Tingting Shang,1,* Fengjuan Wang,1 Yang Cao,1 Lan Hao,1 JianLi Ren,1,2 Haitao Ran,1,2 Zhigang Wang,1,2 Pan Li,1,2 Zhiyu Du3 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, 2Department of Ultrasound, 3Postgraduate Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China *These authors contributed equally to this work Abstract: The commonly used ultrasound (US molecular probes, such as targeted microbubbles and perfluorocarbon emulsions, present a number of inherent problems including the conflict between US visualization and particle penetration. This study describes the successful fabrication of phase changeable folate-targeted perfluoropentane nanodroplets (termed FA-NDs, a novel US molecular probe for tumor molecular imaging with US. Notably, these FA-NDs can be triggered by low-intensity focused US (LIFU sonication, providing excellent US enhancement in B-mode and contrast-enhanced US mode in vitro. After intravenous administration into nude mice bearing SKOV3 ovarian carcinomas, 1,1'-dioctadecyl-3,3,3',3' -tetramethylindotricarbocyanine iodide-labeled FA-NDs were found to accumulate in the tumor region. FA-NDs injection followed by LIFU sonication exhibited remarkable US contrast enhancement in the tumor region. In conclusion, combining our elaborately developed FA-NDs with LIFU sonication provides a potential protocol for US molecular imaging in folate receptor-overexpressing tumors. Keywords: low-intensity focused ultrasound, perfluoropentane nanodroplets, acoustic droplet vaporization, ultrasound molecular imaging, targeting

  12. Fast lesion mapping during HIFU treatment using harmonic motion imaging guided focused ultrasound (HMIgFUS) in vitro and in vivo

    Science.gov (United States)

    Han, Yang; Wang, Shutao; Payen, Thomas; Konofagou, Elisa

    2017-04-01

    The successful clinical application of high intensity focused ultrasound (HIFU) ablation depends on reliable monitoring of the lesion formation. Harmonic motion imaging guided focused ultrasound (HMIgFUS) is an ultrasound-based elasticity imaging technique, which monitors HIFU ablation based on the stiffness change of the tissue instead of the echo intensity change in conventional B-mode monitoring, rendering it potentially more sensitive to lesion development. Our group has shown that predicting the lesion location based on the radiation force-excited region is feasible during HMIgFUS. In this study, the feasibility of a fast lesion mapping method is explored to directly monitor the lesion map during HIFU. The harmonic motion imaging (HMI) lesion map was generated by subtracting the reference HMI image from the present HMI peak-to-peak displacement map, as streamed on the computer display. The dimensions of the HMIgFUS lesions were compared against gross pathology. Excellent agreement was found between the lesion depth (r 2  =  0.81, slope  =  0.90), width (r 2  =  0.85, slope  =  1.12) and area (r 2  =  0.58, slope  =  0.75). In vivo feasibility was assessed in a mouse with a pancreatic tumor. These findings demonstrate that HMIgFUS can successfully map thermal lesions and monitor lesion development in real time in vitro and in vivo. The HMIgFUS technique may therefore constitute a novel clinical tool for HIFU treatment monitoring.

  13. Three-dimensional analysis of Eu dopant atoms in Ca-α-SiAlON via through-focus HAADF-STEM imaging.

    Science.gov (United States)

    Saito, Genki; Yamaki, Fuuta; Kunisada, Yuji; Sakaguchi, Norihito; Akiyama, Tomohiro

    2017-01-31

    Three-dimensional (3D) distributional analysis of individual dopant atoms in materials is important to development of optical, electronic, and magnetic materials. In this study, we adopted through-focus high-angle annular dark-field (HAADF) imaging for 3D distributional analysis of Eu dopant atoms in Ca-α-SiAlON phosphors. In this context, the effects of convergence semi-angle and Eu z-position on the HAADF image contrast were investigated. Multi-slice image simulation revealed that the contrast of the dopant site was sensitive to change of the defocus level. When the defocus level matched the depth position of a Eu atom, the contrast intensity was significantly increased. The large convergence semi-angle greatly increased the depth resolution because the electron beam tends spread instead of channeling along the atomic columns. Through-focus HAADF-STEM imaging was used to analyze the Eu atom distribution surrounding 10nm cubes with defocus steps of 0.68nm each. The contrast depth profile recorded with a narrow step width clearly analyzed the possible depth positions of Eu atoms. The radial distribution function obtained for the Eu dopants was analyzed using an atomic distribution model that was based on the assumption of random distribution. The result suggested that the Ca concentration did not affect the Eu distribution. The decreased fraction of neighboring Eu atoms along z-direction might be caused by the enhanced short-range Coulomb-like repulsive forces along the z-direction.

  14. Luxury for the Masses : A Study of the H&M Luxury Collaborations with Focus on the Images of the Luxury Designer Brands

    OpenAIRE

    Ginman, Carole; Lundell, Charlotte; Turek, Catherine

    2010-01-01

    A strong brand is important for all companies; however, it is imperative for the success of a luxury fashion house as the image is one of its core assets. As strategic alliances are increasing in popularity the effect they have on how customers look at the partner brands is both interesting for the general person, but also – and more importantly – vital knowledge for companies pondering such a strategic move. The major focus of this study is to answer the question of how luxury designers’ col...

  15. Feasibility of magnetic resonance imaging-guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lies anterior to uterus

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Lian; Chen Wenzhi [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Liu Yinjiang; Hu Xiao [National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Zhou Kun [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Chen Li [National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Peng Song; Zhu Hui [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Zou Huiling [National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Bai Jin [Institute of Ultrasound Engineering in Medicine of Chongqing University of Medical Sciences, Chongqing 400016 (China); Wang Zhibiao [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Institute of Ultrasound Engineering in Medicine of Chongqing University of Medical Sciences, Chongqing 400016 (China)], E-mail: wangzhibiao@haifu.com.cn

    2010-02-15

    Purpose: To prospectively evaluate the feasibility of magnetic resonance (MR) imaging-guided high intensity focused ultrasound (HIFU) therapeutic ablation of uterine fibroids in patients with bowel lies anterior to uterus. Materials and methods: Twenty-one patients with 23 uterine fibroids underwent MR imaging-guided high intensity focused ultrasound treatment, with a mean age of 39.4 {+-} 6.9 (20-49) years, with fibroids average measuring 6.0 {+-} 1.6 (range, 2.9-9.5) cm in diameter. After being compressed with a degassed water balloon on abdominal wall, MR imaging-guided high intensity focused ultrasound treatment was performed under conscious sedation by using fentanyl and midazolam. This procedure was performed by a Haifu JM focused ultrasound tumour therapeutic system (JM2.5C, Chongqing Haifu Technology Co., Ltd., China), in combination with a 1.5-Tesla MRI system (Symphony, Siemens, Germany), which provides real-time guidance and control. Contrast-enhanced MR imaging was performed to evaluate the efficacy of thermal ablation immediately and 3 months after HIFU treatment. The treatment time and adverse events were recorded. Results: The mean fibroid volume was 97.0 {+-} 78.3 (range, 12.7-318.3) cm{sup 3}. According to the treatment plan, an average 75.0 {+-} 11.4% (range, 37.8-92.4%) of the fibroid volume was treated. The mean fibroid volume immediately after HIFU was 109.7 {+-} 93.1 (range, 11.9-389.6) cm{sup 3}, slightly enlarged because of edema. The average non-perfused volume was 83.3 {+-} 71.7 (range, 7.7-282.9) cm{sup 3}, the average fractional ablation, which was defined as non-perfused volume divided by the fibroid volume immediately after HIFU treatment, was 76.9 {+-} 18.7% (range, 21.0-97.0%). There were no statistically significant differences between the treatment volume and the non-perfused volume. Follow-up magnetic resonance imaging (MRI) at 3 months obtained in 12 patients, the fibroid volume decreased by 31.4 {+-} 29.3% (range, -1.9 to 60

  16. 基于微多普勒效应的ISAR成像干扰新方法%A Novel Jamming Method for Dechirping ISAR Based on Micro-Doppler Effect

    Institute of Scientific and Technical Information of China (English)

    李松; 何劲; 冯有前; 刘昌云; 张群

    2012-01-01

    本文从分析雷达目标微多普勒效应的产生机理出发,提出了针对ISAR成像的干扰新方法.一方面,针对现有基于微多普勒特征的雷达目标识别技术,干扰机将接收到的雷达信号进行移频和幅度调制处理后转发,生成虚假的微多普勒特征,实现对敌方雷达系统的欺骗干扰;另一方面,利用微多普勒效应对雷达回波的附加调制作用,干扰机发射虚假微多普勒信号,通过降低回波各次距离像之间的相关性和破坏距离像的初相信息,可有效干扰敌方成像系统的运动补偿处理,并在方位向生成干扰条带,对敌方1SAR系统形成“灵巧”抑制干扰,使其无法实现对目标的有效成像.仿真和实测数据处理均表明基于微多普勒效应的干扰方法可在较低干信比条件下实现对ISAR成像系统的有效干扰.%A novel algorithm for ISAR (Inverse synthetic aperture radar) jamming based on the micro-Doppler effect is proposed in the paper. A deception jamming method is presented first, in which the radar signals are repeated by the jammer with additional illusive micro-Doppler signatures after frequency-shift and amplitude-modulation. When receiving these jamming signals, the imaging radar will be confused. On the other hand, because of the additional modulation of the micro-Doppler effect to the radar echoes, the illusive micro-Doppler signals transmitted by the jammer can reduce the correlation between the range profiles, distort the initial phases, and form interference stripes along the azimuth direction. Therefore, another "smart" barrage jamming method is presented based on the micro-Doppler effect. The results of both simulated and measured data prove the effectiveness of these methods with relatively low jam-to-signal ratio.

  17. Comparison of continuous vs. pulsed focused ultrasound in treated muscle tissue as evaluated by magnetic resonance imaging, histological analysis, and microarray analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hundt, Walter [Stanford University School of Medicine, Lucas MRS Research Center, Department of Radiology, Stanford, CA (United States); Ludwig Maximilians University of Munich, Department of Radiology, Munich (Germany); Yuh, Esther L.; Bednarski, Mark D.; Guccione, Samira [Stanford University School of Medicine, Lucas MRS Research Center, Department of Radiology, Stanford, CA (United States); Steinbach, Silke [Technical University of Munich, Department of Otolaryngology Head and Neck Surgery, Munich (Germany)

    2008-05-15

    The purpose of this study was to investigate the effect of different application modes of high intensity focused ultrasound (HIFU) to muscle tissue. HIFU was applied to muscle tissue of the flank in C3H/Km mice. Two dose regimes were investigated, a continuous HIFU and a short-pulsed HIFU mode. Three hours after HIFU treatment pre- and post-contrast T1-weighted, T2-weighted images and a diffusion-weighted STEAM sequence were obtained. After MR imaging, the animals were euthenized and the treated, and the non-treated tissue was taken out for histology and functional genomic analysis. T2 images showed increased signal intensity and post-contrast T1 showed a decreased contrast uptake in the central parts throughout the tissue of both HIFU modes. A significantly higher diffusion coefficient was found in the muscle tissue treated with continuous wave focused ultrasound. Gene expression analysis revealed profound changes of 54 genes. For most of the analyzed genes higher expression was found after treatment with the short-pulse mode. The highest up-regulated genes encoded for the MHC class III (FC {approx}84), HSP 70 (FC {approx}75) and FBJ osteosarcoma related oncogene (FC {approx}21). Immunohistology and the immunoblot analysis confirmed the presence of HSP70 protein in both applied HIFU modes. The use of HIFU treatment on muscle tissue results in dramatic changes in gene expression; however, the same genes are up-regulated after the application of continuous or pulsed HIFU, indicating that the tissue reaction is independent of the type of tissue damage. (orig.)

  18. Near Real-Time Estimation of Super-Resolved Depth and All-In-Focus Images from a Plenoptic Camera Using Graphics Processing Units

    Directory of Open Access Journals (Sweden)

    J. P. Lüke

    2010-01-01

    Full Text Available Depth range cameras are a promising solution for the 3DTV production chain. The generation of color images with their accompanying depth value simplifies the transmission bandwidth problem in 3DTV and yields a direct input for autostereoscopic displays. Recent developments in plenoptic video-cameras make it possible to introduce 3D cameras that operate similarly to traditional cameras. The use of plenoptic cameras for 3DTV has some benefits with respect to 3D capture systems based on dual stereo cameras since there is no need for geometric and color calibration or frame synchronization. This paper presents a method for simultaneously recovering depth and all-in-focus images from a plenoptic camera in near real time using graphics processing units (GPUs. Previous methods for 3D reconstruction using plenoptic images suffered from the drawback of low spatial resolution. A method that overcomes this deficiency is developed on parallel hardware to obtain near real-time 3D reconstruction with a final spatial resolution of 800×600 pixels. This resolution is suitable as an input to some autostereoscopic displays currently on the market and shows that real-time 3DTV based on plenoptic video-cameras is technologically feasible.

  19. Can pre- and postoperative magnetic resonance imaging predict recurrence-free survival after whole-gland high-intensity focused ablation for prostate cancer?

    Energy Technology Data Exchange (ETDEWEB)

    Rosset, Remy; Bratan, Flavie [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Crouzet, Sebastien [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urology, Lyon (France); Universite de Lyon, Lyon (France); Faculte de Medecine Lyon Est, Universite Lyon 1, Lyon (France); Inserm, U1032, LabTau, Lyon (France); Tonoli-Catez, Helene [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urology, Lyon (France); Mege-Lechevallier, Florence [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Pathology, Lyon (France); Gelet, Albert [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urology, Lyon (France); Inserm, U1032, LabTau, Lyon (France); Rouviere, Olivier [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Faculte de Medecine Lyon Est, Universite Lyon 1, Lyon (France); Inserm, U1032, LabTau, Lyon (France)

    2017-04-15

    Our aim was to assess whether magnetic resonance imaging (MRI) features predict recurrence-free survival (RFS) after prostate cancer high-intensity focused ultrasound (HIFU) ablation. We retrospectively selected 81 patients who underwent (i) whole-gland HIFU ablation between 2007 and 2011 as first-line therapy or salvage treatment after radiotherapy or brachytherapy, and (ii) pre- and postoperative MRI. On preoperative imaging, two senior (R1, R2) and one junior (R3) readers assessed the number of sectors invaded by the lesion with the highest Likert score (dominant lesion) using a 27-sector diagram. On postoperative imaging, readers assessed destruction of the dominant lesion using a three-level score. Multivariate analysis included the number of sectors invaded by the dominant lesion, its Likert and destruction scores, the pre-HIFU prostate-specific antigen (PSA) level, Gleason score, and the clinical setting (primary/salvage). The most significant predictor was the number of prostate sectors invaded by the dominant lesion for R2 and R3 (p≤0.001) and the destruction score of the dominant lesion for R1 (p = 0.011). The pre-HIFU PSA level was an independent predictor for R2 (p = 0.014), but with only marginal significance for R1 (p = 0.059) and R3 (p = 0.053). The dominant lesion's size and destruction assessed by MRI provide independent prognostic information compared with usual predictors. (orig.)

  20. Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.

    Science.gov (United States)

    Thévenot, Emmanuel; Jordão, Jessica F; O'Reilly, Meaghan A; Markham, Kelly; Weng, Ying-Qi; Foust, Kevin D; Kaspar, Brian K; Hynynen, Kullervo; Aubert, Isabelle

    2012-11-01

    Noninvasive drug delivery to the brain remains a major challenge for the treatment of neurological disorders. Transcranial focused ultrasound combined with lipid-coated gas microspheres injected into the bloodstream has been shown to increase the permeability of the blood-brain barrier locally and transiently. Coupled with magnetic resonance imaging, ultrasound can be guided to allow therapeutics administered in the blood to reach brain regions of interest. Using this approach, we perform gene transfer from the blood to specific regions of the mouse brain. Focused ultrasound was targeted to the right hemisphere, at multiple foci, or restricted to one focal point of the hippocampus or the striatum. Doses from 5 × 10(8) to 1.25 × 10(10) vector genomes per gram (VG/g) of self-complementary adeno-associated virus serotype 9 carrying the green fluorescent protein were injected into the tail vein. A dose of 2.5 × 10(9) VG/g was optimal to express the transgene, 12 days later, in neurons, astrocytes, and oligodendrocytes in brain regions targeted with ultrasound, while minimizing the infection of peripheral organs. In the hippocampus and striatum, predominantly neurons and astrocytes were infected, respectively. Transcranial focused ultrasound applications could fulfill a long-term goal of gene therapy: delivering vectors to diseased brain areas directly from the circulation, in a noninvasive manner.

  1. HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy

    Science.gov (United States)

    Yan, Sijing; LU, Min; Ding, Xiaoya; Chen, Fei; He, Xuemei; Xu, Chunyan; Zhou, Hang; Wang, Qi; Hao, Lan; Zou, Jianzhong

    2016-01-01

    This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV3 cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both in vitro and in vivo. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV3 cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic. PMID:27535093

  2. Magnetic resonance imaging for the exploitation of bubble-enhanced heating by high-intensity focused ultrasound: a feasibility study in ex vivo liver.

    Science.gov (United States)

    Elbes, Delphine; Denost, Quentin; Robert, Benjamin; Köhler, Max O; Tanter, Mickaël; Bruno, Quesson

    2014-05-01

    Bubble-enhanced heating (BEH) may be exploited to improve the heating efficiency of high-intensity focused ultrasound in liver and to protect tissues located beyond the focal point. The objectives of this study, performed in ex vivo pig liver, were (i) to develop a method to determine the acoustic power threshold for induction of BEH from displacement images measured by magnetic resonance acoustic radiation force imaging (MR-ARFI), and (ii) to compare temperature distribution with MR thermometry for HIFU protocols with and without BEH. The acoustic threshold for generation of BEH was determined in ex vivo pig liver from MR-ARFI calibration curves of local tissue displacement resulting from sonication at different powers. Temperature distributions (MR thermometry) resulting from "conventional" sonications (20 W, 30 s) were compared with those from "composite" sonications performed at identical parameters, but after a HIFU burst pulse (0.5 s, acoustic power over the threshold for induction of BEH). Displacement images (MR-ARFI) were acquired between sonications to measure potential modifications of local tissue displacement associated with modifications of tissue acoustic characteristics induced by the burst HIFU pulse. The acoustic threshold for induction of BEH corresponded to a displacement amplitude of approximately 50 μm in ex vivo liver. The displacement and temperature images of the composite group exhibited a nearly spherical pattern, shifted approximately 4 mm toward the transducer, in contrast to elliptical shapes centered on the natural focal position for the conventional group. The gains in maximum temperature and displacement values were 1.5 and 2, and the full widths at half-maximum of the displacement data were 1.7 and 2.2 times larger than in the conventional group in directions perpendicular to ultrasound propagation axes. Combination of MR-ARFI and MR thermometry for calibration and exploitation of BEH appears to increase the efficiency and safety

  3. HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy

    Science.gov (United States)

    Yan, Sijing; Lu, Min; Ding, Xiaoya; Chen, Fei; He, Xuemei; Xu, Chunyan; Zhou, Hang; Wang, Qi; Hao, Lan; Zou, Jianzhong

    2016-08-01

    This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV3 cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both in vitro and in vivo. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV3 cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic.

  4. An adaptive multi-focus image fusion algorithm based on NSCT%基于NSCT的自适应多聚焦图像融合算法

    Institute of Scientific and Technical Information of China (English)

    施文娟

    2012-01-01

    针对非降采样轮廓波变换(NSCT)具有多尺度、方向性和平移不变性等特点,为改善融合后图像模糊现象,提出了一种基于区域特性的非降采样轮廓波变换的多聚焦图像融合算法。该算法结合NSCT的特点,将图像进行NSCT,变换为不同方向的各子带信息;然后基于局部均值和局部方差选择低频子带系数,并在带通方向子带中引用局部方向对比度作为测量算子来选择带通方向子带系数;最后,通过反变换得到融合图像。实验结果表明,本算法融合效果优于传统的加权平均、小波变换及NSCT算法。%For the nonsubsampled contourlet transform (NSCT)has features of flexible multi-scale, multi-direction and shiftinvariance, to solve the fuzzy phenomenon of fusion images, an adaptive multi-focus image fusion algorithm is proposed based on NSCT and regional feature. It effectively combines characteristics of NSCT, after NSCT, images change into subband information of different direction. The lowpass subband coefficients is selected based on the local energy and local variance. The bandpass directional subbands coefficients is selected by introducing the local directonal contrast as measuring operator. At last, fusion image is obtained through inverse transform. Experimental results indicate that this algorithm performs better than the traditional methods based on weighted average, the wavelet transform and NSCT.

  5. Focused ultrasound in ophthalmology

    Directory of Open Access Journals (Sweden)

    Silverman RH

    2016-09-01

    Full Text Available Ronald H Silverman1,2 1Department of Ophthalmology, Columbia University Medical Center, 2F.L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, NY, USA Abstract: The use of focused ultrasound to obtain diagnostically significant information about the eye goes back to the 1950s. This review describes the historical and technological development of ophthalmic ultrasound and its clinical application and impact. Ultrasound, like light, can be focused, which is crucial for formation of high-resolution, diagnostically useful images. Focused, single-element, mechanically scanned transducers are most common in ophthalmology. Specially designed transducers have been used to generate focused, high-intensity ultrasound that through thermal effects has been used to treat glaucoma (via cilio-destruction, tumors, and other pathologies. Linear and annular transducer arrays offer synthetic focusing in which precise timing of the excitation of independently addressable array elements allows formation of a converging wavefront to create a focus at one or more programmable depths. Most recently, linear array-based plane-wave ultrasound, in which the array emits an unfocused wavefront and focusing is performed solely on received data, has been demonstrated for imaging ocular anatomy and blood flow. While the history of ophthalmic ultrasound extends back over half-a-century, new and powerful technologic advances continue to be made, offering the prospect of novel diagnostic capabilities. Keywords: ophthalmic ultrasound, ultrasound biomicroscopy (UBM, high-intensity focused ultrasound (HIFU, ultrafast imaging, Doppler imaging 

  6. 重力资料聚焦反演成像改进及其应用%Focusing inversion image improvement and application of gravity data

    Institute of Scientific and Technical Information of China (English)

    栗学磊; 李文成; 王凤刚; 王俊山; 刘蒙恩

    2013-01-01

    In practical application of focusing inversion,there are two problems need to be solved in time:the skin effect of imaging and excessive convergency of anomalous source.Skin effect problem can be solved by restraining focusing inversion using index depth weight function.The results show that the depth weight method does well in limiting the convergency of too much anomalous sources in the surface.In order to control the excessive convergency of the anomalous sources,the authors proposed the expansion of anomalous source method which makes the remnant anomalous sources expand out of the anomalous body iteratively.The experimental results indicate that the imaging effect using expansion of anomalous source method was much better than that by using conventional chopping of anomalous sources.%聚焦反演在实际应用中面临着两个问题需要及时解决:成像的趋肤效应和异常体的过度聚合.利用指数深度加权函数来约束聚焦反演可以克服趋肤效应.结果表明,深度加权可以很好地限制过多异常源在地表的聚合.对于异常体的过度聚合,本文提出了异常源外扩方法,该方法将超出限制的异常源进行向异常体外的迭代式扩充.实验表明,异常体外扩方法成像效果优于常规的异常源截除方法.

  7. 3D tracking of single nanoparticles and quantum dots in living cells by out-of-focus imaging with diffraction pattern recognition

    Science.gov (United States)

    Gardini, Lucia; Capitanio, Marco; Pavone, Francesco S.

    2015-11-01

    Live cells are three-dimensional environments where biological molecules move to find their targets and accomplish their functions. However, up to now, most single molecule investigations have been limited to bi-dimensional studies owing to the complexity of 3d-tracking techniques. Here, we present a novel method for three-dimensional localization of single nano-emitters based on automatic recognition of out-of-focus diffraction patterns. Our technique can be applied to track the movements of single molecules in living cells using a conventional epifluorescence microscope. We first demonstrate three-dimensional localization of fluorescent nanobeads over 4 microns depth with accuracy below 2 nm in vitro. Remarkably, we also establish three-dimensional tracking of Quantum Dots, overcoming their anisotropic emission, by adopting a ligation strategy that allows rotational freedom of the emitter combined with proper pattern recognition. We localize commercially available Quantum Dots in living cells with accuracy better than 7 nm over 2 microns depth. We validate our technique by tracking the three-dimensional movements of single protein-conjugated Quantum Dots in living cell. Moreover, we find that important localization errors can occur in off-focus imaging when improperly calibrated and we give indications to avoid them. Finally, we share a Matlab script that allows readily application of our technique by other laboratories.

  8. Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

    Science.gov (United States)

    Chu, Po-Chun; Chai, Wen-Yen; Tsai, Chih-Hung; Kang, Shih-Tsung; Yeh, Chih-Kuang; Liu, Hao-Li

    2016-09-01

    Focused ultrasound (FUS) with microbubbles can temporally open the blood-brain barrier (BBB), and the cavitation activities of microbubbles play a key role in the BBB-opening process. Previous attempts used contrast-enhanced magnetic resonance imaging (CE-MRI) to correlate the mechanical index (MI) with the scale of BBB-opening, but MI only partially gauged acoustic activities, and CE-MRI did not fully explore correlations of pharmacodynamic/pharmacokinetic behaviors. Recently, the cavitation index (CI) has been derived to serve as an indicator of microbubble-ultrasound stable cavitation, and may also serve as a valid indicator to gauge the level of FUS-induced BBB opening. This study investigates the feasibility of gauging FUS-induced BBB opened level via the two indexes, MI and CI, through dynamic contrast-enhanced (DCE)-MRI analysis as well as passive cavitation detection (PCD) analysis. Pharmacodynamic/pharmacokinetic parameters derived from DCE-MRI were characterized to identify the scale of FUS-induced BBB opening. Our results demonstrated that DCE-MRI can successfully access pharmacodynamic/pharmacokinetic BBB-opened behavior, and was highly correlated both with MI and CI, implying the feasibility in using these two indices to gauge the scale of FUS-induced BBB opening. The proposed finding may facilitate the design toward using focused ultrasound as a safe and reliable noninvasive CNS drug delivery.

  9. Development of an imaging mitigation strategy for patient enrolment in the tanezumab nerve growth factor inhibitor (NGF-ab) program with a focus on eligibility assessment.

    Science.gov (United States)

    Roemer, Frank W; Miller, Colin G; West, Christine R; Brown, Mark T; Sherlock, Sarah P; Kompel, Andrew J; Diaz, Luis; Galante, Nicholas; Crema, Michel D; Guermazi, Ali

    2017-05-20

    Nerve growth factor antibodies (NGF-ab) have shown promising analgesic efficacy. Aim was to describe reader training efforts and present reliability data focusing on radiographic eligibility in the tanezumab program. A multi-step process was used for reader calibration and reliability testing. First, a reference standard set of cases was created and diagnostic performance was evaluated. A second exercise focused on agreement of ordinal assessment (Kellgren-Lawrence grading) of radiographic osteoarthritis. Subsequently, 11 readers were trained and read a test set of 100 cases focused on eligibility assessments. Additional reliability testing and calibration of five core readers assessing eligibility of 30 cases was performed 3 and 6 months after study start. Sensitivity for the reference standard readings ranged from 0.50 to 0.90 and specificity from 0.40 to 0.83. Overall agreement for Kellgren-Lawrence grading ranged from 71.4% to 82.9%. For the 11 reader exercise, in 76% of cases at least 8 of 11 readers agreed on eligibility status. For the reliability testing 3 months after study start, in 80.0% of cases at least 4 of 5 readers agreed on eligibility with a κ = 0.43 (95% CI: 0.32-0.54). For the reliability testing after 6 months, in 83.3% of cases at least 4 of 5 readers agreed on eligibility with a κ = 0.52 (95% CI: 0.41-0.63). After intense efforts spent in the development of an imaging program for an NGF-ab clinical program, the achieved reliability for eligibility assessment is substantial but not perfect. Ongoing efforts of calibration prior to including additional readers to the program and during study conduct between current readers will be needed to ensure agreement on potential adverse events and radiographic disease severity. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. The evaluation of FDG-PET imaging for epileptogenic focus localization in patients with MRI positive and MRI negative temporal lobe epilepsy

    Energy Technology Data Exchange (ETDEWEB)

    Gok, Beril [Drexel University, Department of Radiology, Mercy Catholic Medical Center, Philadelphia, PA (United States); Johns Hopkins University, Division of Nuclear Medicine, Department of Radiology and Radiological Sciences, Baltimore, MD (United States); Jallo, George [Johns Hopkins University, Department of Neurosurgery, Baltimore, MD (United States); Hayeri, Reza [Drexel University, Department of Radiology, Mercy Catholic Medical Center, Philadelphia, PA (United States); Wahl, Richard [Johns Hopkins University, Division of Nuclear Medicine, Department of Radiology and Radiological Sciences, Baltimore, MD (United States); Aygun, Nafi [Johns Hopkins University, Division of Neuroradiology, Department of Radiology and Radiological Sciences, Baltimore, MD (United States)

    2013-05-15

    We studied the contribution of interictal FDG-PET ([18 F] fluorodeoxyglucose-positron emission tomography) in epileptic focus identification in temporal lobe epilepsy patients with positive, equivocal and negative magnetic resonance imaging (MRI). Ninety-eight patients who underwent surgical treatment for drug resistant temporal lobe epilepsy after neuropsychological evaluation, scalp video EEG monitoring, FDG-PET, MRI and/or long-term intracranial EEG and with >12 months clinical follow-up were included in this study. FDG-PET findings were compared to MRI, histopathology, scalp video EEG and long-term intracranial EEG monitoring. FDG-PET lateralized the seizure focus in 95 % of MRI positive, 69 % of MRI equivocal and 84 % of MRI negative patients. There was no statistically significant difference between the surgical outcomes among the groups with Engel class I and II outcomes achieved in 86 %, 86 %, 84 % of MRI positive, equivocal and negative temporal lobe epilepsy patients, respectively. The patients with positive unilateral FDG-PET demonstrated excellent postsurgical outcomes, with 96 % Engel class I and II. Histopathology revealed focal lesions in 75 % of MRI equivocal, 84 % of MRI positive, and 23 % of MRI negative temporal lobe epilepsy cases. FDG-PET is an accurate noninvasive method in lateralizing the epileptogenic focus in temporal lobe epilepsy, especially in patients with normal or equivocal MRIs, or non-lateralized EEG monitoring. Very subtle findings in MRI are often associated with histopathological lesions and should be described in MRI reports. The patients with negative or equivocal MRI temporal lobe epilepsy are good surgical candidates with comparable postsurgical outcomes to patients with MRI positive temporal lobe epilepsy. (orig.)

  11. Ion focusing

    Energy Technology Data Exchange (ETDEWEB)

    Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

    2017-01-17

    The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

  12. Portable high-intensity focused ultrasound system with 3D electronic steering, real-time cavitation monitoring, and 3D image reconstruction algorithms: a preclinical study in pigs

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jin Woo; Lee, Jae Young; Hwang, Eui Jin; Hwang, In Pyeong; Woo, Sung Min; Lee, Chang Joo; Park, Eun Joo; Choi, Byung Ihn [Dept. of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul (Korea, Republic of)

    2014-10-15

    The aim of this study was to evaluate the safety and accuracy of a new portable ultrasonography-guided high-intensity focused ultrasound (USg-HIFU) system with a 3-dimensional (3D) electronic steering transducer, a simultaneous ablation and imaging module, real-time cavitation monitoring, and 3D image reconstruction algorithms. To address the accuracy of the transducer, hydrophones in a water chamber were used to assess the generation of sonic fields. An animal study was also performed in five pigs by ablating in vivo thighs by single-point sonication (n=10) or volume sonication (n=10) and ex vivo kidneys by single-point sonication (n=10). Histological and statistical analyses were performed. In the hydrophone study, peak voltages were detected within 1.0 mm from the targets on the y- and z-axes and within 2.0-mm intervals along the x-axis (z-axis, direction of ultrasound propagation; y- and x-axes, perpendicular to the direction of ultrasound propagation). Twenty-nine of 30 HIFU sessions successfully created ablations at the target. The in vivo porcine thigh study showed only a small discrepancy (width, 0.5-1.1 mm; length, 3.0 mm) between the planning ultrasonograms and the pathological specimens. Inordinate thermal damage was not observed in the adjacent tissues or sonic pathways in the in vivo thigh and ex vivo kidney studies. Our study suggests that this new USg-HIFU system may be a safe and accurate technique for ablating soft tissues and encapsulated organs.

  13. UMA ANÁLISE CRÍTICA ENTRE OS CURRÍCULOS DOS CURSOS DE CIÊNCIAS CONTÁBEIS NOS PAÍSES DO MERCOSUL E O PROPOSTO PELA ONU/UNCTAD/ISAR

    Directory of Open Access Journals (Sweden)

    Giovanna Tonetto Segantini

    2013-07-01

    Full Text Available A harmonização das normas contábeis tornou-se uma necessidade dos usuários externos e in-ternos da informação contábil, uma vez que passaram a atuar em diversos mercados e a prestar contas aos usuários com necessidades variadas, pois o mercado cada vez mais globalizado exige profissionais preparados para atuar dentro e fora do seu país. Visando isso, a ONU/UNCTAD/ISAR desenvolveu um Currículo Mundial para servir de referência para os cursos de Ciências Contábeis, buscando prover conhecimentos internacionais de normas contábeis independentemente do país responsável pela formação do profissional. Assim, o objetivo geral do artigo foi analisar e comparar a adequação dos currículos dos cursos de ciências contá-beis de quatro universidades do MERCOSUL, sendo uma de cada país, com o currículo proposto pela ONU/UNCTAD/ISAR. As universidades selecionadas foram: Facultad de Ciencias Econômicas de la Universidad de Buenos Aires (Argentina; Faculdade de Economia, Administração e Con-tabilidade da Universidade de São Paulo (Brasil; Universidad Nacional de Asunción (Paraguai; e Facultad de Ciências Econômicas y de Administración de la Universidad de la República (Uruguai, e suas matrizes curriculares foram comparadas com o Currículo Mundial proposto pela ONU/UNCTAD/ISAR. Os resultados indicam que a similaridade entre os currículos das quatro universidades selecionadas com o proposto pela ONU/UNCTAD/ISAR é alta, existindo, em mé-dia, 76,71% de semelhança entre as matérias dos currículos. Por ser apenas uma recomendação, as universidades pesquisadas demonstraram possuir certa flexibilidade na elaboração de seus currículos.

  14. Uma Análise Crítica Entre os Currículos dos Cursos de Ciências Contábeis nos Países do Mercosul e o Proposto Pela ONU/UNCTAD/ISAR

    Directory of Open Access Journals (Sweden)

    Giovanna Tonetto Segantini

    2013-07-01

    Full Text Available A harmonização das normas contábeis tornou-se uma necessidade dos usuários externos e internos da informação contábil, uma vez que passaram a atuar em diversos mercados e a prestar contas aos usuários com necessidades variadas, pois o mercado cada vez mais globalizado exige profissionais preparados para atuar dentro e fora do seu país. Visando isso, a ONU/UNCTAD/ISAR desenvolveu um Currículo Mundial para servir de referência para os cursos de Ciências Contábeis, buscando prover conhecimentos internacionais de normas contábeis independentemente do país responsável pela formação do profissional. Assim, o objetivo geral do artigo foi analisar e comparar a adequação dos currículos dos cursos de ciências contábeis de quatro universidades do MERCOSUL, sendo uma de cada país, com o currículo proposto pela ONU/UNCTAD/ISAR. As universidades selecionadas foram: Facultad de Ciencias Econômicas de la Universidad de Buenos Aires (Argentina; Faculdade de Economia, Administração e Contabilidade da Universidade de São Paulo (Brasil; Universidad Nacional de Asunción (Paraguai; e Facultad de Ciências Econômicas y de Administración de la Universidad de la República (Uruguai, e suas matrizes curriculares foram comparadas com o Currículo Mundial proposto pela ONU/UNCTAD/ISAR. Os resultados indicam que a similaridade entre os currículos das quatro universidades selecionadas com o proposto pela ONU/UNCTAD/ISAR é alta, existindo, em média, 76,71% de semelhança entre as matérias dos currículos. Por ser apenas uma recomendação, as universidades pesquisadas demonstraram possuir certa flexibilidade na elaboração de seus currículos.

  15. Images

    Data.gov (United States)

    National Aeronautics and Space Administration — Images for the website main pages and all configurations. The upload and access points for the other images are: Website Template RSW images BSCW Images HIRENASD...

  16. Feeding the hungry river: Fluvial morphodynamics and the entrainment of artificially inserted sediment at the dammed river Isar, Eastern Alps, Germany

    Science.gov (United States)

    Heckmann, Tobias; Haas, Florian; Abel, Judith; Rimböck, Andreas; Becht, Michael

    2017-08-01

    Dams interrupt the sediment continuum in rivers by retaining the bedload; combined with flow diversion, bedload retention in tributaries and river engineering measures, this causes a bedload deficit leading to changes in river planform and morphodynamics, with potentially detrimental downstream effects. As part of the SedAlp joint project (Sediment management in Alpine basins: integrating sediment continuum, risk mitigation and hydropower), this study investigates changes within a section of the dammed river Isar between the Sylvenstein reservoir and the city of Bad Tölz. We use a multi-method approach on a range of spatial and temporal scales. First, we analysed historical maps and aerial photos to analyse river planform and landcover changes within the river corridor of the whole study area on a temporal scale of over 100 years. Results show that major changes occurred before the construction of the Sylvenstein reservoir, suggesting that present morphodynamics represent the reaction to different disturbances on different time scales. Second, changes in mean bed elevation of cross profiles regularly surveyed by the water authorities are analysed in light of artificial sediment insertion and floods; they are also used to estimate the sediment budget of river reaches between consecutive cross profiles. Results suggest stability and a slight tendency towards incision, especially near the Sylvenstein reservoir; further downstream, the sediment balance was positive. Third, we acquired multitemporal aerial photos using an unmanned aerial vehicle and generated high-resolution digital elevation models to show how sediment artificially inserted in the river corridor is entrained. Depending on the position of the artificial deposits in relation to the channel, the deposits are entrained during floods of different return periods.

  17. Method for characterization of a spherically bent crystal for K.alpha. X-ray imaging of laser plasmas using a focusing monochromator geometry

    Science.gov (United States)

    Kugland, Nathan; Doeppner, Tilo; Glenzer, Siegfried; Constantin, Carmen; Niemann, Chris; Neumayer, Paul

    2015-04-07

    A method is provided for characterizing spectrometric properties (e.g., peak reflectivity, reflection curve width, and Bragg angle offset) of the K.alpha. emission line reflected narrowly off angle of the direct reflection of a bent crystal and in particular of a spherically bent quartz 200 crystal by analyzing the off-angle x-ray emission from a stronger emission line reflected at angles far from normal incidence. The bent quartz crystal can therefore accurately image argon K.alpha. x-rays at near-normal incidence (Bragg angle of approximately 81 degrees). The method is useful for in-situ calibration of instruments employing the crystal as a grating by first operating the crystal as a high throughput focusing monochromator on the Rowland circle at angles far from normal incidence (Bragg angle approximately 68 degrees) to make a reflection curve with the He-like x-rays such as the He-.alpha. emission line observed from a laser-excited plasma.

  18. Imaging of intracellular spherical lamellar structures and tissue gross morphology by a focused ion beam/scanning electron microscope (FIB/SEM)

    Energy Technology Data Exchange (ETDEWEB)

    Drobne, Damjana [Department of Biology, University of Ljubljana, Vecna pot 111, SI-1000 Ljubljana (Slovenia)], E-mail: damjana.drobne@bf.uni-lj.si; Milani, Marziale [Materials Science Department, University of Milano-Bicocca, Via Cozzi 53, I-20125 Milano (Italy); Leser, Vladka [Department of Biology, University of Ljubljana, Vecna pot 111, SI-1000 Ljubljana (Slovenia); Tatti, Francesco [FEI Italia, Via Cervi 40, I-00139 Roma (Italy); Zrimec, Alexis [Institute of Physical Biology, Velika Loka 90, SI-1290 Grosuplje (Slovenia); Znidarsic, Nada; Kostanjsek, Rok; Strus, Jasna [Department of Biology, University of Ljubljana, Vecna pot 111, SI-1000 Ljubljana (Slovenia)

    2008-06-15

    We report the use of a focused ion beam/scanning electron microscope (FIB/SEM) for simultaneous investigation of digestive gland epithelium gross morphology and ultrastructure of multilamellar intracellular structures. Digestive glands of a terrestrial isopod (Porcellio scaber, Isopoda, Crustacea) were examined by FIB/SEM and by transmission electron microscopy (TEM). The results obtained by FIB/SEM and by TEM are comparable and complementary. The FIB/SEM shows the same ultrastructural complexity of multilamellar intracellular structures as indicated by TEM. The term lamellar bodies was used for the multillamellar structures in the digestive glands of P. scaber due to their structural similarity to the lamellar bodies found in vertebrate lungs. Lamellar bodies in digestive glands of different animals vary in their abundance, and number as well as the thickness of concentric lamellae per lamellar body. FIB/SEM revealed a connection between digestive gland gross morphological features and the structure of lamellar bodies. Serial slicing and imaging of cells enables easy identification of the contact between a lamellar body and a lipid droplet. There are frequent reports of multilamellar intracellular structures in different vertebrate as well as invertebrate cells, but laminated cellular structures are still poorly known. The FIB/SEM can significantly contribute to the structural knowledge and is always recommended when a link between gross morphology and ultrastrucutre is investigated, especially when cells or cellular inclusions have a dynamic nature due to normal, stressed or pathological conditions.

  19. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Jessica F Jordão

    Full Text Available Immunotherapy for Alzheimer's disease (AD relies on antibodies directed against toxic amyloid-beta peptide (Abeta, which circulate in the bloodstream and remove Abeta from the brain. In mouse models of AD, the administration of anti-Abeta antibodies directly into the brain, in comparison to the bloodstream, was shown to be more efficient at reducing Abeta plaque pathology. Therefore, delivering anti-Abeta antibodies to the brain of AD patients may also improve treatment efficiency. Transcranial focused ultrasound (FUS is known to transiently-enhance the permeability of the blood-brain barrier (BBB, allowing intravenously administered therapeutics to enter the brain. Our goal was to establish that anti-Abeta antibodies delivered to the brain using magnetic resonance imaging-guided FUS (MRIgFUS can reduce plaque pathology. To test this, TgCRND8 mice received intravenous injections of MRI and FUS contrast agents, as well as anti-Abeta antibody, BAM-10. MRIgFUS was then applied transcranially. Within minutes, the MRI contrast agent entered the brain, and BAM-10 was later found bound to Abeta plaques in targeted cortical areas. Four days post-treatment, Abeta pathology was significantly reduced in TgCRND8 mice. In conclusion, this is the first report to demonstrate that MRIgFUS delivery of anti-Abeta antibodies provides the combined advantages of using a low dose of antibody and rapidly reducing plaque pathology.

  20. Joint Cross-Range Scaling and 3D Geometry Reconstruction of ISAR Targets Based on Factorization Method.

    Science.gov (United States)

    Lei Liu; Feng Zhou; Xue-Ru Bai; Ming-Liang Tao; Zi-Jing Zhang

    2016-04-01

    Traditionally, the factorization method is applied to reconstruct the 3D geometry of a target from its sequential inverse synthetic aperture radar images. However, this method requires performing cross-range scaling to all the sub-images and thus has a large computational burden. To tackle this problem, this paper proposes a novel method for joint cross-range scaling and 3D geometry reconstruction of steadily moving targets. In this method, we model the equivalent rotational angular velocity (RAV) by a linear polynomial with time, and set its coefficients randomly to perform sub-image cross-range scaling. Then, we generate the initial trajectory matrix of the scattering centers, and solve the 3D geometry and projection vectors by the factorization method with relaxed constraints. After that, the coefficients of the polynomial are estimated from the projection vectors to obtain the RAV. Finally, the trajectory matrix is re-scaled using the estimated rotational angle, and accurate 3D geometry is reconstructed. The two major steps, i.e., the cross-range scaling and the factorization, are performed repeatedly to achieve precise 3D geometry reconstruction. Simulation results have proved the effectiveness and robustness of the proposed method.

  1. Without 'Focus'

    Directory of Open Access Journals (Sweden)

    Aldo Sevi

    2010-12-01

    Full Text Available It is widely accepted that a notion of 'focus', more or less as conceived of in Jackendoff (1972, must be incorporated into our theory of grammar, as a means of accounting for certain observed correlations between prosodic facts and semantic/pragmatic facts. In this paper, we put forth the somewhat radical idea that the time has come to give up this customary view, and eliminate 'focus' from our theory of grammar. We argue that such a move is both economical and fruitful.Research over the years has revealed that the correlations between prosody, 'focus', and the alleged semantic/pragmatic effects of focus are much less clear and systematic than we may have initially hoped. First we argue that this state of affairs detracts significantly from the utility of our notion of 'focus', to the point of calling into question the very motivation for including it in the grammar. Then we look at some of the central data, and show how they might be analyzed without recourse to a notion of 'focus'. We concentrate on (i the effect of pitch accent placement on discourse congruence, and (ii the choice of 'associate' for the so-called 'focus sensitive' adverb only. We argue that our focus-free approach to the data improves empirical coverage, and begins to reveal patterns that have previously been obscured by preconceptions about 'focus'.ReferencesBeaver, D. & Clark, B. 2008. Sense and Sensitivity: How Focus Determines Meaning. Blackwell.Beaver, D., Clark, B., Flemming, E., Jaeger, T. F. & Wolters, M. 2007. ‘When semantics meets phonetics: Acoustical studies of second occurrence focus’. Language 83.2: 245–76.http://dx.doi.org/10.1353/lan.2007.0053Beckman, M. & Hirschberg, J. 1994. ‘The ToBI Annotation Conventions’. Ms.,http://www.cs.columbia.edu/~julia/files/conv.pdf.Bolinger, D. 1972. ‘Accent is predictable (if you are a mind-reader’. Language 48.3: 633–44.http://dx.doi.org/10.2307/412039Büring, D. 2006. ‘Focus projection and default

  2. 一种基于图像处理的舌象采集自动调焦算法%An auto-focus algorithm for tongue image acquisition based on image processing

    Institute of Scientific and Technical Information of China (English)

    韦玉科; 李江平; 段仰广; 卢博生

    2011-01-01

    为快速准确地采集到清晰的舌图像,必需智能调整并控制摄像镜头与舌体的位置。提出了影响图像质量的因素,如清晰度、反光比、对中性、阴影比、光照条件、焦距等,以及在调整镜物位置时用到的调焦的方法,并与调焦技术相结合,建立了适合图像质量与镜物距离之间关系的数学模型。自动对焦的过程就是运用爬山搜索算法求取对焦评价函数最大值的过程。传统的爬山搜索算法会受到对焦评价函数局部极值的干扰而不能准确对焦,本研究对每一帧图像先进行预处理,然后采用先粗后精两步法,有效地排除了这种干扰。用VC++6.0编程实现了自动调整采集设备获取质量最佳图片的过程。试验结果表明此方法具有快速、抗干扰强、精确等特性。%To rapidly and accurately acquire a clear tongue image needs adjusting and controlling of the distance between camera and the tongue.This study elaborated the factors that influence image quality such as clarity,light reflection,shade,illumination condition and focal length and the focusing method used in adjusting the position of lens and subject.Combined with focus technology,this paper established a mathematical model of the relation of image quality and distance of lens and subject.The procedure of auto-focus was the acquisition of the maximum value of the focusing evaluation function employing the mountain-climb searching algorithm.Unlike the traditional mountain-climb searching algorithm which was apt to be disturbed by the local extremum,an algorithm that preprocessed each frame of image was first introduced and the two step method of rough before precision was used,which effectively got rid of this disturbance.It was realized by using the VC++6.0 program to automatically adjust the acquisition machine to acquire the best quality picture.Experimental results showed that this method was fast,precise,strongly anti

  3. Magnetic-resonance imaging for kinetic analysis of permeability changes during focused ultrasound-induced blood-brain barrier opening and brain drug delivery.

    Science.gov (United States)

    Chai, Wen-Yen; Chu, Po-Chun; Tsai, Meng-Yen; Lin, Yu-Chun; Wang, Jiun-Jie; Wei, Kuo-Chen; Wai, Yau-Yau; Liu, Hao-Li

    2014-10-28

    Focused ultrasound (FUS) with the presence of microbubbles has been shown to induce transient and local opening of the blood-brain barrier (BBB) for the delivery of therapeutic molecules which normally cannot penetrate into the brain. The success of FUS brain-drug delivery relies on its integration with in-vivo imaging to monitor kinetic change of therapeutic molecules into the brain. In this study, we developed a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) technique for kinetic analysis of delivered molecules during FUS-BBB opening. Three kinetic parameters (Ktrans, Ve, Kep) were characterized dynamically to describe BBB-permeability at two FUS exposure conditions (0.4 or 0.8MPa) over 24h. Ktrans, defined as the influx volume transfer constant from plasma to EES, and Ve, the EES volume fraction, were both found to be pressure-dependent. Ktrans and Ve showed a peak increase of 0.0086-0.0131min(-1) (for 0.4-0.8MPa pressure), and 0.0431-0.0692, respectively, immediately after FUS exposure. Both parameters subsequently decreased exponentially as a function of time, with estimated half-lives of decay of 2.89-5.3 and 2.2-4.93h, respectively. The kinetics of Kep, defined as the efflux rate constant from the extracellular extravascular space (EES) to the plasma, were complementary to Ktrans, with an initial decrease from 0.2010 to 0.1901min(-1) followed by a significantly longer recovery time (half-life of 17.39-99.92h). Our observations strongly supported the existence of imbalanced and mismatched kinetics of influx (Ktrans) and efflux (Kep) between the plasma and EES, indicating the existence of directional permeability during FUS-BBB opening. We further showed that kinetic change determined by DCE-MRI correlated well with the concentration of Evans Blue (EB)-albumin (coefficient of 0.74-0.89). These findings suggest that MRI kinetic monitoring may serve as an alternative method for in-vivo monitoring of pharmacokinetics and pharmacodynamics (PK

  4. Identifying factors likely to influence compliance with diagnostic imaging guideline recommendations for spine disorders among chiropractors in North America: a focus group study using the Theoretical Domains Framework

    Directory of Open Access Journals (Sweden)

    Bussières André E

    2012-08-01

    Full Text Available Abstract Background The Theoretical Domains Framework (TDF was developed to investigate determinants of specific clinical behaviors and inform the design of interventions to change professional behavior. This framework was used to explore the beliefs of chiropractors in an American Provider Network and two Canadian provinces about their adherence to evidence-based recommendations for spine radiography for uncomplicated back pain. The primary objective of the study was to identify chiropractors’ beliefs about managing uncomplicated back pain without x-rays and to explore barriers and facilitators to implementing evidence-based recommendations on lumbar spine x-rays. A secondary objective was to compare chiropractors in the United States and Canada on their beliefs regarding the use of spine x-rays. Methods Six focus groups exploring beliefs about managing back pain without x-rays were conducted with a purposive sample. The interview guide was based upon the TDF. Focus groups were digitally recorded, transcribed verbatim, and analyzed by two independent assessors using thematic content analysis based on the TDF. Results Five domains were identified as likely relevant. Key beliefs within these domains included the following: conflicting comments about the potential consequences of not ordering x-rays (risk of missing a pathology, avoiding adverse treatment effects, risks of litigation, determining the treatment plan, and using x-ray-driven techniques contrasted with perceived benefits of minimizing patient radiation exposure and reducing costs; beliefs about consequences; beliefs regarding professional autonomy, professional credibility, lack of standardization, and agreement with guidelines widely varied ( social/professional role & identity; the influence of formal training, colleagues, and patients also appeared to be important factors ( social influences; conflicting comments regarding levels of confidence and comfort in managing patients

  5. Focus: Digital

    DEFF Research Database (Denmark)

    Technology has been an all-important and defining element within the arts throughout the 20th century, and it has fundamentally changed the ways in which we produce and consume music. With this Focus we investigate the latest developments in the digital domain – and their pervasiveness and rapid...... production and reception of contemporary music and sound art. With ‘Digital’ we present four composers' very different answers to how technology impact their work. To Juliana Hodkinson it has become an integral part of her sonic writing. Rudiger Meyer analyses the relationships between art and design and how...

  6. Focusing horn

    CERN Multimedia

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet.For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  7. Differential X-ray phase-contrast imaging with a grating interferometer using a laboratory X-ray micro-focus tube

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Kwon-Ha; Ryu, Jong-Hyun; Jung, Chang-Won [Wonkwang University School of Medicine, Iksan (Korea, Republic of); Ryu, Cheol-Woo; Kim, Young-Jo; Kwon, Young-Man [Jeonbuk Technopark, Iksan (Korea, Republic of); Park, Mi-Ran; Cho, Seung-Ryong [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Chon, Kwon-Su [Catholic University of Daegu, Gyeongsan (Korea, Republic of)

    2014-12-15

    X-ray phase-contrast imaging can provide images with much greater soft-tissue contrast than conventional absorption-based images. In this paper, we describe differential X-ray phase-contrast images of insect specimens that were obtained using a grating-based Talbot interferometer and a laboratory X-ray source with a spot size of a few tens of micrometers. We developed the interferometer on the basis of the wavelength, periods, and height of the gratings; the field of view depends on the size of the grating, considering the refractive index of the specimen. The phase-contrast images were acquired using phase-stepping methods. The phase contrast imaging provided a significantly enhanced soft-tissue contrast compared with the attenuation data. The contour of the sample was clearly visible because the refraction from the edges of the object was strong in the differential phase-contrast image. Our results demonstrate that a grating-based Talbot interferometer with a conventional X-ray tube may be attractive as an X-ray imaging system for generating phase images. X-ray phase imaging obviously has sufficient potential and is expected to soon be a great tool for medical diagnostics.

  8. Fat-suppressed volume isotropic turbo spin echo acquisition (VISTA) MR imaging in evaluating radial and root tears of the meniscus: Focusing on reader-defined axial reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Daekeon; Lee, Young Han; Kim, Sungjun; Song, Ho-Taek; Suh, Jin-Suck, E-mail: jss@yuhs.ac

    2013-12-01

    Objective: To assess the diagnostic value of fat-suppressed (FS) three-dimensional (3D) volume isotropic turbo spin echo acquisition (VISTA) imaging in detecting radial and root tears of the meniscus, including the reader-defined reformatted axial (RDA) plane. Materials and methods: Twenty-three patients with arthroscopically confirmed radial or root tears of the meniscus underwent magnetic resonance imaging (MRI) with 2D and FS 3D VISTA sequences. MRIs were reviewed independently by two musculoskeletal radiologists blinded to the arthroscopic findings. Sensitivity, specificity, accuracy, and interobserver agreement were calculated for radial and root tears. Both radiologists reported confidence scale for the presence of meniscal tears in 2D axial imaging, 3D axial imaging, and RDA imaging, based on a five-point scale. Wilcoxon's signed rank test was used to compare confidence scale. Results: The sensitivity, specificity, and accuracy of FS 3D VISTA MR imaging versus 2D MR imaging were as follows: 96%, 96%, and 96% versus 91%, 91%, and 91%, respectively in reader 1, and 96%, 96%, and 96% versus 83%, 91%, and 87%, respectively, in reader 2. Interobserver agreement for detecting meniscal tears was excellent (κ = 1) with FS 3D VISTA. The confidence scale was significantly higher for 3D axial images than 2D imaging (p = 0.03) and significantly higher in RDA images than 3D axial image in detecting radial and root tears. Conclusions: FS 3D VISTA had a better diagnostic performance in evaluating radial and root tears of the meniscus. The reader-defined reformatted axial plane obtained from FS 3D VISTA MR imaging is useful in detecting radial and root tears of the meniscus.

  9. 联合运动补偿的逆合成孔径雷达成像方位定标方法%Joint method of motion compensation and cross-range scajing for inverse synthetic aperture radar imaging

    Institute of Scientific and Technical Information of China (English)

    盛佳恋; 张磊; 邢孟道; 徐刚; 贺丽

    2014-01-01

    在雷达识别系统中,确定目标的尺寸对于提高目标识别能力具有重要的意义。针对逆合成孔径雷达(inverse synthetic aperture radar,ISAR)成像的定标问题,考虑了等效转台和残余平动引入的相位误差,提出了一种 ISAR 目标有效转动速度估计的新方法。通过在距离多普勒图像中自适应提取若干目标特征点,对其建立时变自回归模型(time-varying autoregressive,TVAR)。利用多项式拟合极点的多普勒历程,解算有效转动速度与残余相位误差系数。该方法不仅能可靠实现方位定标,残余的相位误差补偿可进一步提高图像的聚焦性能。仿真和实测数据实验验证了所提方法的有效性。%In radar target recognition systems,it is of great significance to determine the target size for im-proving the capability of identification.Considering the phase error induced by the equivalent turntable and re-sidual translation,this paper proposes a new method to estimate effective rotation velocity for inverse synthetic aperture radar (ISAR)cross-range scaling.By extracting some featured scatterers in the range-Doppler image,a time-varying autoregressive (TVAR)model is invoked for the scatterers.After polyfitting the Doppler histories of the poles,effective rotation velocity and residual phase error can be calculated.One contribution of this method lies in that it can reliably implement cross-range scaling.Simultaneously,the motion compensation processing can further improve the target focus.Simulation and real-data experiments verify the effectiveness of this proposal.

  10. New released DR detector (Canon CXDI 70C wireless) tested at premature neonates chest examination focusing on dose and image quality

    DEFF Research Database (Denmark)

    Precht, Helle

    2011-01-01

    maintaining image quality at a diagnostic level. Methods and Materials A quantitative experimental study based on experiments with technical and human phantoms. A technical CDRad phantom was used and the images were analyzed using CDRad software, giving results as objective IQF values. A human neonates chest...

  11. Focusing on media body ideal images triggers food intake among restrained eaters: a test of restraint theory and the elaboration likelihood model.

    Science.gov (United States)

    Boyce, Jessica A; Kuijer, Roeline G

    2014-04-01

    Although research consistently shows that images of thin women in the media (media body ideals) affect women negatively (e.g., increased weight dissatisfaction and food intake), this effect is less clear among restrained eaters. The majority of experiments demonstrate that restrained eaters - identified with the Restraint Scale - consume more food than do other participants after viewing media body ideal images; whereas a minority of experiments suggest that such images trigger restrained eaters' dietary restraint. Weight satisfaction and mood results are just as variable. One reason for these inconsistent results might be that different methods of image exposure (e.g., slideshow vs. film) afford varying levels of attention. Therefore, we manipulated attention levels and measured participants' weight satisfaction and food intake. We based our hypotheses on the elaboration likelihood model and on restraint theory. We hypothesised that advertent (i.e., processing the images via central routes of persuasion) and inadvertent (i.e., processing the images via peripheral routes of persuasion) exposure would trigger differing degrees of weight dissatisfaction and dietary disinhibition among restrained eaters (cf. restraint theory). Participants (N = 174) were assigned to one of four conditions: advertent or inadvertent exposure to media or control images. The dependent variables were measured in a supposedly unrelated study. Although restrained eaters' weight satisfaction was not significantly affected by either media exposure condition, advertent (but not inadvertent) media exposure triggered restrained eaters' eating. These results suggest that teaching restrained eaters how to pay less attention to media body ideal images might be an effective strategy in media-literary interventions. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Autofocus system and autofocus method for focusing on a surface

    Energy Technology Data Exchange (ETDEWEB)

    O' Neill, Mary Morabito

    2017-05-23

    An autofocus system includes an imaging device, a lens system and a focus control actuator that is configured to change a focus position of the imaging device in relation to a stage. The electronic control unit is configured to control the focus control actuator to a plurality of predetermined focus positions, and activate the imaging device to obtain an image at predetermined positions and then apply a spatial filter to the obtained images. This generates a filtered image for the obtained images. The control unit determines a focus score for the filtered images such that the focus score corresponds to a degree of focus in the obtained images. The control unit identifies a best focus position by comparing the focus score of the filtered images, and controls the focus control actuator to the best focus position corresponding to the highest focus score.

  13. Moving Canadian governmental policies beyond a focus on individual lifestyle: some insights from complexity and critical theories.

    Science.gov (United States)

    Alvaro, C; Jackson, L A; Kirk, S; McHugh, T L; Hughes, J; Chircop, A; Lyons, R F

    2011-03-01

    This paper explores why Canadian government policies, particularly those related to obesity, are 'stuck' at promoting individual lifestyle change. Key concepts within complexity and critical theories are considered a basis for understanding the continued emphasis on lifestyle factors in spite of strong evidence indicating that a change in the environment and conditions of poverty isare needed to tackle obesity. Opportunities to get 'unstuck' from individual-level lifestyle interventions are also suggested by critical concepts found within these two theories, although getting 'unstuck' will also require cross-sectoral collective action. Our discussion focuses on the Canadian context but will undoubtedly be relevant to other countries, where health promoters and others engage in similar struggles for fundamental government policy change.

  14. Differential impact of multi-focus fan beam collimation with L-mode and conventional systems on the accuracy of myocardial perfusion imaging: Quantitative evaluation using phantoms

    Directory of Open Access Journals (Sweden)

    Tatsunori Saho

    2013-10-01

    Full Text Available Introduction: A novel IQ-SPECTTM method has become widely used in clinical studies. The present study compares the quality of myocardial perfusion images (MPI acquired using the IQ-SPECTTM (IQ-mode,conventional (180° apart: C-mode and L-mode (90° apart: L-mode systems. We assessed spatial resolution, image reproducibility and quantifiability using various physical phantoms. Materials and Methods: SPECT images were acquired using a dual-headed gamma camera with C-mode, L-mode, and IQ-mode acquisition systems from line source, pai and cardiac phantoms containing solutions of 99mTc. The line source phantom was placed in the center of the orbit and at ± 4.0, ± 8.0, ± 12.0, ± 16.0 and ± 20.0 cm off center. We examined quantifiability using the pai phantom comprising six chambers containing 0.0, 0.016, 0.03, 0.045, 0.062, and 0.074 MBq/mLof 99m-Tc and cross-calibrating the SPECT counts. Image resolution and reproducibility were quantified as myocardial wall thickness (MWT and %uptake using polar maps. Results: The full width at half maximum (FWHM of the IQ-mode in the center was increased by 11% as compared with C-mode, and FWHM in the periphery was increased 41% compared with FWHM at the center. Calibrated SPECT counts were essentially the same when quantified using IQ-and C-modes. IQ-SPECT images of MWT were significantly improved (P<0.001 over L-mode, and C-mode SPECT imaging with IQ-mode became increasingly inhomogeneous, both visually and quantitatively (C-mode vs. L-mode, ns; C-mode vs. IQ-mode, P<0.05. Conclusion: Myocardial perfusion images acquired by IQ-SPECT were comparable to those acquired by conventional and L-mode SPECT, but with significantly improved resolution and quality. Our results suggest that IQ-SPECT is the optimal technology for myocardial perfusion SPECT imaging.

  15. Development of a Model for Measuring Scientific Processing Skills Based on Brain-Imaging Technology: Focused on the Experimental Design Process

    Science.gov (United States)

    Lee, Il-Sun; Byeon, Jung-Ho; Kim, Young-shin; Kwon, Yong-Ju

    2014-01-01

    The purpose of this study was to develop a model for measuring experimental design ability based on functional magnetic resonance imaging (fMRI) during biological inquiry. More specifically, the researchers developed an experimental design task that measures experimental design ability. Using the developed experimental design task, they measured…

  16. Value of probe-based confocal laser endomicroscopy (pCLE) and dual focus narrow-band imaging (dNBI) in diagnosing early squamous cell neoplasms in esophageal Lugol’s voiding lesions

    OpenAIRE

    Prueksapanich, Piyapan; Pittayanon, Rapat; Rerknimitr, Rungsun; Wisedopas, Naruemon; Kullavanijaya, Pinit

    2015-01-01

    Background and study aims: Lugol’s chromoendoscopy provides excellent sensitivity for the detection of early esophageal squamous cell neoplasms (ESCN), but its specificity is suboptimal. An endoscopy technique for real-time histology is required to decrease the number of unnecessary biopsies. This study aimed to compare the ESCN diagnostic capability of probed-based confocal laser endomicroscopy (pCLE) and dual focus narrow-band imaging (dNBI) in Lugol’s voiding lesions. Patients and methods:...

  17. Image city

    DEFF Research Database (Denmark)

    2003-01-01

    Image city exhibition explores a condition of mediation, through a focus on image and sound narratives with a point of departure on a number of Asian cities.......Image city exhibition explores a condition of mediation, through a focus on image and sound narratives with a point of departure on a number of Asian cities....

  18. Imaging-based characterization of cardiometabolic phenotypes focusing on whole-body MRI--an approach to disease prevention and personalized treatment.

    Science.gov (United States)

    Gatidis, Sergios; Schlett, Christopher L; Notohamiprodjo, Mike; Bamberg, Fabian

    2016-01-01

    Metabolic syndrome and cardiovascular disorders pose a challenge to global healthcare systems. Too often, patients with metabolic syndrome are diagnosed in advanced disease stages, where disease-associated damage is irreversible and treatment options are limited. Thus, prevention plays an increasingly important role in the management of cardiometabolic disorders. The main challenge of prevention is to identify patient groups who are at risk for developing overt disease and who might benefit from early therapeutic intervention. In this context, imaging-based phenotyping can add significant information to clinical evaluations, revealing anatomical and physiological changes that reflect intrinsic and extrinsic risk factors. The purpose of this review article was to provide an overview of the current state of imaging-based phenotyping of metabolic syndrome and cardiovascular disorders and to discuss current and potential developments in this field.

  19. Scientific Objectives and Design Study of an Adaptive Optics Visual Echelle Spectrograph and Imager Coronograph (AVES-IMCO) for the NAOS Visitor Focus at the VLT

    Science.gov (United States)

    Pallavicini, Roberto; Zerbi, Filippo; Beuzit, Jean-Luc; Bonanno, Giovanni; Bonifacio, Piercarlo; Comari, Maurizio; Conconi, Paolo; Delabre, Bernard; Franchini, Mariagrazia; Marcantonio, Paolo Di; Lagrange, Anne-Marie; Mazzoleni, Ruben; Molaro, Paolo; Pasquini, Luca; Santin, Paolo

    We present the scientific case for an Adaptive Optics Visual Echelle Spectrograph and Imager Coronograph (AVES-IMCO) that we propose as a visitor instrument for the secondary port of NAOS at the VLT. We show that such an instrument would be ideal for intermediate resolution (R=16,000) spectroscopy of faint sky-limited objects down to a magnitude of V=24.0 and will complement very effectively the near-IR imaging capabilities of CONICA. We present examples of science programmes that could be carried out with such an instrument and which cannot be addressed with existing VLT instruments. We also report on the result of a two-year design study of the instrument, with specific reference to its use as parallel instrument of NAOS.

  20. Nanoparticles Formed by Acoustic Destruction of Microbubbles and Their Utilization for Imaging and Effects on Therapy by High Intensity Focused Ultrasound

    Science.gov (United States)

    Blum, Nicholas T.; Yildirim, Adem; Chattaraj, Rajarshi; Goodwin, Andrew P.

    2017-01-01

    This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C4F10, C5F12, or C6F14) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs) are of 150 nm average diameter and can be re-imaged for up to an hour after creation for C 4F10, and for at least one day for C5F12. The active species were found to be fluid (gas or liquid) filled nanoparticles rather than lipid debris. The acoustic droplet vaporization threshold of the nanoparticles was found to vary with the vapor pressure of the encapsulated fluorocarbon, and integrated image brightness was found to increase dramatically when the temperature was raised above the normal boiling point of the fluorocarbon. Finally, the vaporization threshold decreases in serum as compared to buffer, and administration of HIFU to the nanoparticles caused breast cancer cells to completely detach from their culture substrate. This work demonstrates a new functionality of microbubbles that could serve as a platform technology for ultrasound-based theranostics. PMID:28255360

  1. Method for the determination of the modulation transfer function (MTF) in 3D x-ray imaging systems with focus on correction for finite extent of test objects

    Science.gov (United States)

    Schäfer, Dirk; Wiegert, Jens; Bertram, Matthias

    2007-03-01

    It is well known that rotational C-arm systems are capable of providing 3D tomographic X-ray images with much higher spatial resolution than conventional CT systems. Using flat X-ray detectors, the pixel size of the detector typically is in the range of the size of the test objects. Therefore, the finite extent of the "point" source cannot be neglected for the determination of the MTF. A practical algorithm has been developed that includes bias estimation and subtraction, averaging in the spatial domain, and correction for the frequency content of the imaged bead or wire. Using this algorithm, the wire and the bead method are analyzed for flat detector based 3D X-ray systems with the use of standard CT performance phantoms. Results on both experimental and simulated data are presented. It is found that the approximation of applying the analysis of the wire method to a bead measurement is justified within 3% accuracy up to the first zero of the MTF.

  2. 基于非向下采样Contourlet变换的多聚焦图像融合%MULTI-FOCUS IMAGE FUSION BASED ON NON-SUBSAMPLED CONTOURLET TRANSFORM

    Institute of Scientific and Technical Information of China (English)

    王玲; 李红松; 周浩; 朱丽青; 杨永锋

    2011-01-01

    In recent years, image fusion has become the focus of image processing. This paper presents a multi-focus image fusion method based on Non-subsampled Contourlet transform. Firstly, the Non-subsampled Contourlet transform is conducted on two pairs of source images respectively to get a low-frequency sub-band and a number of high-frequency directional sub-bands; and then the fusion rules of regional mean of directional contrast and of local entropy are adopted on high and low-frequency sub-bands respectively to select the corresponding coefficient; finally, the fused image is obtained through inverse transform. The proposed method, discrete wavelet transform, atrot s wavelet transform and a simple method of NSCT are compared in experiment, the result show that the fusion effect of the proposed method is the best.%近年来图像融合已成为图像处理的一个热点,提出了一种基于非向下采样Contourlet变换NSCT(Nonsubsampled Contour-let transform)的多聚焦图像融合方法.首先对两幅源图像分别进行非向下采样轮廓波变换得到一个低频子带和多个高频方向子带,然后对高低频子带分别采取方向对比度的区域均值和局部熵的融合规则来选取相应的系数,最终通过反变换得到融合图像.实验中,与离散小波、atrous小波变换、NSCT的简单方法进行了比较,结果表明该方法的融合效果最好.

  3. Radar Super-Resolution Imaging Based on Compressive Sensing%压缩感知雷达超分辨率成像

    Institute of Scientific and Technical Information of China (English)

    邓振淼; 叶淋美; 傅茂忠; 张贻雄

    2014-01-01

    研究压缩感知理论在逆合成孔径雷达(inverse synthetic aperture radar, ISAR)成像中的应用。雷达发射方位稀疏的探测脉冲,对满足Nyquist采样定理的雷达去斜回波数据进行稀疏采样,再利用压缩感知重构算法分别重构距离向和方位向的完整的目标特性回波信号。为了得到高分辨的雷达ISAR像,对重构的数据在距离向和方位向分别进行超分辨率处理。实际雷达数据和仿真数据表明ISAR像的分辨率有较大提高,所给出的综合方法可以降低数据量,节省雷达的时间资源,具有良好的应用价值。%Application of compressed sensing (CS) in inverse synthetic aperture radar is investigated in this paper. The radar transmits sparse probing pulses and dechirped radar echo samples that satisfy the Nyquist sampling theorem are resampled sparsely. Reconstruction is performed to these sparse samples both in range and cross-range directions to recover the whole radar echo signals containing the target characteristics. To obtain high resolution ISAR images, super-resolution processing on both range and cross-range directions is conducted on the reconstructed data. Results of processing on real radar data and simulated data show that the resolution of ISAR image can be enhanced signiifcantly. The proposed algorithm can reduce data size and time consumption, and is valuable for super-resolution radar image applications.

  4. 基于 NSCT与双通道 PCNN 的多聚焦图像融合%Multi-focus Image Fusion Method Based on NSCT and Dual PCNN

    Institute of Scientific and Technical Information of China (English)

    石学萍; 韩晓军; 张南; 王志宽; 武嘉庆

    2016-01-01

    为提高多聚焦图像的清晰度及PCNN在图像融合方面的实用性,提出一种基于NSCT与双通道PCNN的多聚焦图像融合新方法。首先对来自同一场景的多聚焦图像分别进行NSCT变换;然后将基于SML的视觉特性对比度用于低频子带系数的融合;对于高频子带则通过改进的空间频率激励双通道PCNN进行融合,两个通道对应不同的连接强度,根据点火次数确定高频子带融合系数;最后进行逆 NSCT 变换得到最终融合图像。实验结果表明,该融合算法得到的融合图像具有较高的清晰度,在主观和客观评价指标上优于其他算法,具有较好的视觉效果。%In order to improve the multi‐focus image sharpness and the practicability of PCNN in the aspect of image fusion ,a new multi‐focus image fusion method was proposed based on nonsubsampled Contourlet transform (NSCT) and dual‐channel pulse coupled neural network (DCPCNN) .Firstly ,multi‐focus images which from the same scene were decomposed using NSCT respectively ;and then visual properties contrast based on SML was used to fuse low frequency subband coefficients ;High frequency sub‐band component fused through DCPCNN which motivated by modified spatial frequency .DCPCNN had two channels corresponding to different linking strength , high frequency sub‐band fusion coefficient was determined according to the number of ignition .Finally ,the fusion image achieved by inverse transformation of NSCT . The experimental results demonstrate that the proposed algorithm improves fusion image sharpness significantly ,subjective and objective indicators are better than other fusion algorithms ,having better visual effects .

  5. Design of Auto-Focusing System Based on Image Processing for Integration Camera%基于图像处理的一体化摄像机自动聚焦系统设计

    Institute of Scientific and Technical Information of China (English)

    胡建萍; 于鹏

    2012-01-01

    The control function of auto-focusing in integration camera is studied, and digital image processing techniques are used to realize auto-focusing. Using the median filter algorithm as evaluation function of focusing, this algorithm reduces the outside noise interference on the focus,and combined with the traditional camera to choose the focus area with the golden section composition theory,the improved mountain-climbing algorithm is utilized to search the focus. On this basis, auto-focusing can be realized by using the FPGA development platform. Through the experiment proved that this system has a high sensitivity.%研究一体化摄像机中的自动聚焦控制功能,运用数字图像处理技术来实现自动聚焦.采用加权中值滤波算子作为判断图像清晰度的评价函数,此算法可减小外部噪声对聚焦的干扰,并结合传统摄像构图采用的黄金分割理论来选择聚焦区域,然后利用改进的爬山算法来搜索焦点.在此基础上,运用FPGA开发平台实现该自动聚焦技术.通过实验验证,设计的系统的灵敏度高、稳定性好.

  6. Use of focused beam reflectance measurement (FBRM) and process video imaging (PVI) in a modified mixed suspension mixed product removal (MSMPR) cooling crystallizer

    Science.gov (United States)

    Kougoulos, E.; Jones, A. G.; Jennings, K. H.; Wood-Kaczmar, M. W.

    2005-01-01

    The FBRM instrument is a 'powerful' tool developed by Lasentec as an 'in situ' particle monitoring technique for in-line real-time measurement of particle size. This technique was successfully used to monitor steady-state operation in a modified MSMPR crystallizer. The FBRM technique was also used to estimate crystallization kinetics. The FBRM particle size measurements were complimented by an in-line process video imaging (PVI) system developed ' in-house' (Microscopy and Microanalysis, 6 (Suppl. 2) (2000) 996-997), to visualize habit and crystal behaviour within an MSMPR crystallizer. A comparison of the steady-state crystal size distributions measured by low angle light scattering (LALLS) and FBRM was made, showing poor sensitivity of the FBRM technique to particles of less than 1 μm hence the technique was not suitable for the measurement of crystallization kinetics for this organic system.

  7. NPS Focus Digital Library and Research Station

    Data.gov (United States)

    National Park Service, Department of the Interior — Scope: National. NPS Focus Digital Library and Research Station information system manages images and archives of images as well as documents described by linked...

  8. Indexing Images.

    Science.gov (United States)

    Rasmussen, Edie M.

    1997-01-01

    Focuses on access to digital image collections by means of manual and automatic indexing. Contains six sections: (1) Studies of Image Systems and their Use; (2) Approaches to Indexing Images; (3) Image Attributes; (4) Concept-Based Indexing; (5) Content-Based Indexing; and (6) Browsing in Image Retrieval. Contains 105 references. (AEF)

  9. [Imaging].

    Science.gov (United States)

    Chevrot, A; Drapé, J L; Godefroy, D; Dupont, A M; Pessis, E; Sarazin, L; Minoui, A

    1997-01-01

    The panoply of imaging techniques useful in podology is essentially limited to X-rays. Standard "standing" and "lying" X-rays furnish most of the required information. Arthrography is sometimes performed, in particular for trauma or tumour of the ankle. CT scan and MRI make a decisive contribution in difficult cases, notably in fractures and in small fractures without displacement. The two latter techniques are useful in tendon, ligament and muscular disorders, where echography is also informative. Rigorous analysis of radiographies and a good knowledge of foot disorders make these imaging techniques efficacious.

  10. 一种DE搜索块寻优的多聚焦图像融合算法%Algorithm for Multi- focus Image Fusion Using a DE Search-block Optimization

    Institute of Scientific and Technical Information of China (English)

    马文娟; 姬天富

    2012-01-01

    For multi - focus image, a DE (Differential Evolution) search strategy is used in algorithm of sub - block op-timization of the image fusion to discuss in-depth the clarity recovery of the source image with strict registration of the same scene. The fusion process is to divide the registered source image into several sub - blocks and then use the clarity evaluation function to select a clear image to form a fused image. The innovation of this method is that the size of the im- age block is used as a genetic chromosome after the crossover, mutation and selection operations to obtain the optimal so-lution in a global sense. The experimental comparison results show that this method is superior to the genetic algorithm and other conventional multi - focus image fusion method.%针对多聚焦图像,提出了一种DE(差异演化)搜索策略应用于图像融合子块寻优的算法,对同一场景两幅严格配准的源图像的清晰度恢复进行了深入研究。融合过程是首先将已经配准的源图像分割成若干个子块,然后采用一个清晰度评价函数选取清晰的图像块形成融合图像。该方法的创新之处在于,把图像子块的大小作为遗传染色体,经过交叉、变异和选择等操作,以便得到全局意义上的最优解。实验对比结果表明,该方法超过遗传算法和其它传统的多聚焦图像融合法。

  11. Application of dual time phases imaging of 18F-FDG PET/CT to diagnosis of pulmonary sarcoidosis focus%18F-FDG双时相显影在肺结节病灶中的应用

    Institute of Scientific and Technical Information of China (English)

    周克; 吴平; 陈治明; 陈钰

    2011-01-01

    目的 探讨18F-FDG双时相显影在肺结节性病灶诊断与鉴别诊断的临床应用价值.方法 回顾性分析43例18F-FDG双时相显影且经病理证实的肺结节性病例.其中男性31例,女性12例,年龄38~84岁.使用18F-FDG行全身或肺部PET/CT及双时相病灶扫描,依据PET图像、CT图像、PET/CT融合图像进行综合性分析.结果 43例肺结节性病灶的病例中,双时相显影诊断肺癌26例,病理证实23例;诊断可疑肺癌8例,病理证实5例;诊断良性病变9例,病理证实8例.结论 对于肺结节性病灶,应用18F-FDG双时相显影可提高诊断的准确性.%Objective To investigate the clinical application values of dual time phases imaging of 18 F - FDG PET/CT to diagnosis of the diagnosis and differential diagnosis of pulmonary sarcoidosis focus. Methods A retrospective analysis was made in 43 patients( 31 men, 12 women and aged from 38 to 84 years )with detected by dual time phases imaging of 18F - FDG PET/CT and confirmed by pathological examination. They received the whole body or lung PET/CT and dual time phase focal scanning, and a comprehensive analysis was made according to the PET,CT images and PET/CT fusion images. Results Among the 43 subjects,26 ones were diagnosed as lung cancer by the dual time phase imaging and 24 ones were verified by pathological examination; 8 ones were diagnosed as suspicious lung cancer by the dual time phase imaging and 5 ones were verified by pathological examination;9 ones were diagnosed as benign lesion and 8 ones were verified by pathological examination. Conclusion The application of dual time phase imaging of 18F - FDG PET/CT can improve the accuracy of the diagnosis of pulmonary sarcoidosis focus.

  12. 成像毛细管等电聚焦电泳分析糖蛋白类生物技术药物%Analysis of glycoproteins by imaging capillary isoelectric focusing electrophoresis

    Institute of Scientific and Technical Information of China (English)

    王丽; 周勇; 王军志

    2012-01-01

    Objective To develop an imaging capillary isoelectric focusing electrophoresis method for analysis of isomer and isoelectric point of glycoproteins. Methods Three glycoproteins, i.e. recombinant human PEGlysated erythropoietin (PEG-EPO), re-combinant human TNK mutant of tissue type plasminogen activator (rhTNF-tPA) and humanized monoclonal antibody (McAb) A were analyzed for isomers and isoelectric points by imaging capillary isoelectric focusing electrophoresis. Results The isoelectric points and isomers of PEG-EPO, rhTNF-tPA and humanized McAb A were effectively analyzed by the developed imaging capillary isoelectric focusing electrophoresis method. The method was reliable, rapid, and showed high resolution and reproducibility. Conclusion Imaging capillary isoelectric focusing electrophoresis method may be used for analysis of isomer and electric point of glycoproteins, which provides en effective tool for ensuring the stability of production procedure and quality control of glycoproteins.%目的 建立成像毛细管等电聚焦电泳分析糖白蛋类生物技术药物的异构体和等电点的方法.方法 应用优化的成像毛细管等电聚焦电泳技术,对3种糖蛋白类生物技术药物即聚乙二醇化重组人促红素(PEGlysated erythropoietin,PEG-EPO)、重组人组织型纤溶酶原激活剂TNK突变体(Recombinant human TNK mutant of tissue type plasminogen activator,rhTNK-tPA)和全人源化单抗A的异构体和等电点进行分析.结果 采用优化的成像毛细管等电聚焦电泳技术,可较好地分析PEG-EPO、rhTNK-tPA和全人源化单抗A的等电点和异构体,该方法可靠、快速,具有较好的分离度和重现性.结论 成像毛细管等电聚焦电泳技术可用于分析糖蛋白类生物技术药物的异构体和等电点,为保证糖蛋白类生物技术药物生产工艺的稳定性及质量控制提供了有效手段.

  13. Imaging the interphase of carbon fiber composites using transmission electron microscopy:Preparations by focused ion beam, ion beam etching, and ultramicrotomy

    Institute of Scientific and Technical Information of China (English)

    Wu Qing; Li Min; Gu Yizhuo; Wang Shaokai; Zhang Zuoguang

    2015-01-01

    Three sample preparation techniques, focused ion beam (FIB), ion beam (IB) etching, and ultramicrotomy (UM) were used in comparison to analyze the interphase of carbon fiber/epoxy composites using transmission electron microscopy. An intact interphase with a relatively uniform thickness was obtained by FIB, and detailed chemical analysis of the interphase was investigated by electron energy loss spectroscopy. It shows that the interphase region is 200 nm wide with an increasing oxygen-to-carbon ratio from 10% to 19% and an almost constant nitrogen-to-carbon ratio of about 3%. However, gallium implantation of FIB tends to hinder fine structure analysis of the interphase. For IB etching, the interphase region is observed with transition morphology from amorphous resin to nano-crystalline carbon fiber, but the uneven sample thickness brings difficulty for quantitative chemical analysis. Moreover, UM tends to cause damage and/or deformation on the interphase. These results are meaningful for in-depth understanding on the interphase characteristic of carbon fiber composites.

  14. Focus On Photoshop Elements Focus on the Fundamentals

    CERN Document Server

    Asch, David

    2011-01-01

    Are you bewildered by the advanced editing options available in Photoshop Elements? Do you want to get the most out of your image without going bleary-eyed in front of a computer screen? This handy guide will explain the ins and outs of using Photoshop Elements, without having to spend hours staring at the screen. Using a fabulous combination of easy-to-follow advice and step-by-step instructions, Focus On Photoshop Elements gives great advice on setting up, storing and sharing your image library and teaches you the basics of RAW image processing and color correction, plus shows you how to edi

  15. 基于超声相控线阵的缺陷全聚焦三维成像%Three-dimensional total-focus imaging based on ultrasonic linear phased array

    Institute of Scientific and Technical Information of China (English)

    张昊; 陈世利; 贾乐成

    2016-01-01

    In the field of nondestructive testing,three-dimensional imaging has obvious advantages over traditional two-dimensional imaging because it can restore the detail of the flaws inside the material.Three-dimensional imaging with phased array ultrasonic technology has been realized by using matrix arrays,but the equipments can be quite expensive and complex.This paper focuses on the three-dimensional imaging with a linear phased array ultrasonic system,and provides a low-cost and efficient method to generate high quality three-dimensional images. In this method,tomoscan and Full Matrix Capture are used to acquire the data,and then high resolution images of the slices are generated by Total Focus Method,and an acceleration algorithm is proposed to optimize the time-consuming process during TFM.Finally,three-dimensional image is generated by spatial interpolation based on the real locations of the tomograms.An experiment is conducted to validate the approach,and the imaging result is compared with the real flaw distribution inside the aluminum block quantitatively.The experiment demonstrates the effectiveness of the imaging method and the acceleration algorithm.With this method,testing personnel can evaluate the real situation inside the unit under test directly,rather than referring to the B-scan and C-scan images.%在无损检测领域,缺陷三维成像能够还原材料内部缺陷的空间信息,与传统的二维成像相比有着明显的优势。目前实现超声相控阵缺陷三维成像主要依靠面阵探头,而这些设备往往十分复杂和昂贵。通过采取适当的数据采集方法和后处理成像算法,超声相控线阵系统能够实现低成本、高效率的三维超声检测成像。采用断层扫描和全矩阵捕捉的方法获取成像数据;再利用全聚焦成像算法绘制高分辨率的断层图像;根据这些图像在三维空间中真实的位置关系,插值还原出缺陷的三维图像。此外,针对全

  16. Optical illumination and critical dimension analysis using the through-focus focus metric method

    Science.gov (United States)

    Attota, Ravikiran; Silver, Richard M.; Potzick, James

    2006-08-01

    In this paper we present recent developments in optical microscope image analysis using both, best focus optical image as well as those images conventionally considered out of focus for metrology applications. Depending on the type of analysis, considerable information can be deduced with the additional use of the out of focus optical images. One method for analyzing the complete set of images is to calculate the total "edge slope" from an image, as the target is moved through-focus. A plot of the sum of the mean square slope is defined as the through-focus focus metric. We present a unique method for evaluating the angular illumination homogeneity in an optical microscope (with Koehler illumination configuration), based on the through-focus focus metric approach. Both theoretical simulations and experimental results are presented to demonstrate this approach. We present a second application based on the through-focus focus metric method for evaluating critical dimensions (CD) with demonstrated nanometer sensitivity for both experimental and optical simulations. An additional approach to analyzing the complete set of images is to assemble or align the through focus image intensity profiles such that the x-axis represents the position on the target, the y-axis represents the focus (or defocus) position of the target with respect to the lens and the z-axis represents the image intensity. This two-dimensional image is referred to as the through focus image map. Using recent simulation results we apply the through focus image map to CD and overlay analysis and demonstrate nanometer sensitivity in the theoretical results.

  17. Multi-Focus Image Fusion Algorithm Based on Nonsubsampled Contourlet Transform%基于非抽样Contourlet变换的多聚焦图像融合算法

    Institute of Scientific and Technical Information of China (English)

    冯太平; 闫仁武

    2012-01-01

    文中研究了非抽样Contourlet变换(NSCT)的原理,以及其多尺度、局部化、方向性和各向异性等优点.提出了一种基于NSCT的多聚焦图像融合新算法.本算法将多聚焦图像进行NSCT分解,不同子带采用不同的融合规则,低频子带采用新的基于灰度形态学梯度算子的融合算法,并做一致性检测,带通子带采用基于区域能量的融合算法.最后将融合得到的系数进行NSCT反变换得到融合图像.实验结果表明,与其他融合算法相比较,该算法可以更有效地保留源图像信息和细节特征.%The principle of nonsubsampled Contourlet transform and the advantage of multi-scale,localization directionality and anisotro-py are studied in the paper. A new multi-focus image fusion algorithm based on NSCT is developed. Firstly,two different multi-focus source images are decomposed by NSCT. Secondly,different fusion rules are applied in the low and banpass subband coefficients. A new fusion algorithm based on the gray morphology grad operator is applied in lowpass subbands and the consistency check is proposed. The regional energy fusion rule is applied in highpass subbands. Finally,the fused image is reconstructed by the inverse NSCT. The experimental results show that,compared with other algorithms,this fusion method can retain the information and features of source more effectively.

  18. High-throughput automated confocal microscopy imaging screen of a kinase-focused library to identify p38 mitogen-activated protein kinase inhibitors using the GE InCell 3000 analyzer.

    Science.gov (United States)

    Trask, O Joseph; Nickischer, Debra; Burton, Audrey; Williams, Rhonda Gates; Kandasamy, Ramani A; Johnston, Patricia A; Johnston, Paul A

    2009-01-01

    The integration of fluorescent microscopy imaging technologies and image analysis into high-content screening (HCS) has been applied throughout the drug discovery pipeline to identify, evaluate, and advance compounds from early lead generation through preclinical candidate selection. In this chapter we describe the development, validation, and implementation of an HCS assay to screen compounds from a kinase-focused small-molecule library to identify inhibitors of the p38 pathway using the GE InCell 3000 automated imaging platform. The assay utilized a genetically modified HeLa cell line stably expressing mitogen-activated, protein-activating protein kinase-2 fused to enhanced green fluorescent protein (MK2-EGFP) and measured the subcellular distribution of the MK2-EGFP as a direct readout of p38 activation. The MK2-EGFP translocation assay performed in 384-well glass bottom microtiter plates exhibited a robust Z-factor of 0.46 and reproducible EC50 and IC50 determinations for activators and inhibitors, respectively. A total of 32,891 compounds were screened in singlicate at 50 microM and 156 were confirmed as inhibitors of p38-mediated MK2-EGFP translocation in follow-up IC50 concentration response curves. Thirty-one compounds exhibited IC50s less than 1 microM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.

  19. Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion recovery, FLAIR and T2W MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Morimoto, Emiko; Kanagaki, Mitsunori; Okada, Tomohisa; Yamamoto, Akira; Togashi, Kaori [Kyoto University Graduate School of Medicine, Department of Diagnostic Imaging and Nuclear Medicine, Kyoto (Japan); Mori, Nobuyuki [Tenri Hospital, Department of Radiology, Tenri, Nara (Japan); Matsumoto, Riki; Ikeda, Akio; Takahashi, Ryosuke [Kyoto University Graduate School of Medicine, Department of Neurology, Kyoto (Japan); Mikuni, Nobuhiro [Sapporo Medical University, Department of Neurosurgery, Sapporo, Hokkaido (Japan); Kunieda, Takeharu; Miyamoto, Susumu [Kyoto University Graduate School of Medicine, Department of Neurosurgery, Kyoto (Japan); Paul, Dominik [Siemens AG Healthcare Sector, Erlangen (Germany)

    2013-01-15

    To investigate the diagnostic capability of anterior temporal lobe white matter abnormal signal (ATLAS) for determining seizure focus laterality in temporal lobe epilepsy (TLE) by comparing different MR sequences. This prospective study was approved by the institutional review board and written informed consent was obtained. Three 3D sequences (double inversion recovery (DIR), fluid-attenuated inversion recovery (FLAIR) and T2-weighted imaging (T2WI)) and two 2D sequences (FLAIR and T2WI) were acquired at 3 T. Signal changes in the anterior temporal white matter of 21 normal volunteers were evaluated. ATLAS laterality was evaluated in 21 TLE patients. Agreement of independent evaluations by two neuroradiologists was assessed using {kappa} statistics. Differences in concordance between ATLAS laterality and clinically defined seizure focus laterality were analysed using McNemar's test with multiple comparisons. Pre-amygdala high signals (PAHS) were detected in all volunteers only on 3D-DIR. Inter-evaluator agreement was moderate to almost perfect for each sequence. Correct diagnosis of seizure laterality was significantly more frequent on 3D-DIR than on any other sequences (P {<=} 0.031 for each evaluator). The most sensitive sequence for detecting ATLAS laterality was 3D-DIR. ATLAS laterality on 3D-DIR can be a good indicator for determining seizure focus localization in TLE. (orig.)

  20. Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion recovery, FLAIR and T2W MR imaging.

    Science.gov (United States)

    Morimoto, Emiko; Kanagaki, Mitsunori; Okada, Tomohisa; Yamamoto, Akira; Mori, Nobuyuki; Matsumoto, Riki; Ikeda, Akio; Mikuni, Nobuhiro; Kunieda, Takeharu; Paul, Dominik; Miyamoto, Susumu; Takahashi, Ryosuke; Togashi, Kaori

    2013-01-01

    To investigate the diagnostic capability of anterior temporal lobe white matter abnormal signal (ATLAS) for determining seizure focus laterality in temporal lobe epilepsy (TLE) by comparing different MR sequences. This prospective study was approved by the institutional review board and written informed consent was obtained. Three 3D sequences (double inversion recovery (DIR), fluid-attenuated inversion recovery (FLAIR) and T2-weighted imaging (T2WI)) and two 2D sequences (FLAIR and T2WI) were acquired at 3 T. Signal changes in the anterior temporal white matter of 21 normal volunteers were evaluated. ATLAS laterality was evaluated in 21 TLE patients. Agreement of independent evaluations by two neuroradiologists was assessed using κ statistics. Differences in concordance between ATLAS laterality and clinically defined seizure focus laterality were analysed using McNemar's test with multiple comparisons. Pre-amygdala high signals (PAHS) were detected in all volunteers only on 3D-DIR. Inter-evaluator agreement was moderate to almost perfect for each sequence. Correct diagnosis of seizure laterality was significantly more frequent on 3D-DIR than on any other sequences (P ≤ 0.031 for each evaluator). The most sensitive sequence for detecting ATLAS laterality was 3D-DIR. ATLAS laterality on 3D-DIR can be a good indicator for determining seizure focus localization in TLE.

  1. A Matrix Pencil Algorithm Based Multiband Iterative Fusion Imaging Method

    Science.gov (United States)

    Zou, Yong Qiang; Gao, Xun Zhang; Li, Xiang; Liu, Yong Xiang

    2016-01-01

    Multiband signal fusion technique is a practicable and efficient way to improve the range resolution of ISAR image. The classical fusion method estimates the poles of each subband signal by the root-MUSIC method, and some good results were get in several experiments. However, this method is fragile in noise for the proper poles could not easy to get in low signal to noise ratio (SNR). In order to eliminate the influence of noise, this paper propose a matrix pencil algorithm based method to estimate the multiband signal poles. And to deal with mutual incoherent between subband signals, the incoherent parameters (ICP) are predicted through the relation of corresponding poles of each subband. Then, an iterative algorithm which aimed to minimize the 2-norm of signal difference is introduced to reduce signal fusion error. Applications to simulate dada verify that the proposed method get better fusion results at low SNR.

  2. Status of the STIS Instrument Focus

    Science.gov (United States)

    Proffitt, Charles R.; Monroe, TalaWanda; Dressel, Linda

    2017-01-01

    The Space Telescope Imaging Spectrograph needs to bring images to a good focus at its aperture plane and three detectors, for each of several optical paths. We discuss various ways of measuring the evolution of the focus over time for both the aperture plane and for a variety of imaging and spectroscopic modes. Evidence suggests that between 2013 and 2015 the best focus of STIS relative to the HST best focus, based on WFC3/UVIS and ACS/WFC monitoring, shifted by the equivalent of 3 microns of HST secondary motion, resulting in a decrease in the average small aperture throughput. We discuss the implications of this change for STIS observations.

  3. A Multi-focus Image Fusion Algorithm Combining NSCT with Edge Detection%NSCT与边缘检测相结合的多聚焦图像融合算法

    Institute of Scientific and Technical Information of China (English)

    宋瑞霞; 王孟; 王小春

    2016-01-01

    利用非下采样Contourlet变换(NSCT)的系数特点,设计NSCT域中高低频融合规则,并结合基于区域分割的边缘检测算法,针对多聚焦图像提出了一种有效的融合算法。首先通过NSCT变换把2幅待融合图像分解为一个低频系数矩阵和一系列的高频系数矩阵,对低频系数采用局域方差、局域空间频率、局域改进的拉普拉斯能量和3个统计特征的加权平均进行融合,对高频系数基于局部纹理特征进行融合,经过 NSCT 逆变换后得到初步的融合结果;然后根据初步融合图像和待融合图像的残差图识别出清晰区域,对清晰区域进行边缘检测,将该边缘信息覆盖到初步融合的图像上,得到最终的融合图像。与传统DWT, NSCT变换和基于视觉特性的NSCT域图像融合算法进行实验对比的结果表明,该算法在视觉效果和平均梯度、互信息、空间频率与边缘保持度等多个评价指标上均有优势。%According to the characteristics of the coefficients of non-subsampled Contourlet transform (NSCT), new fusion rules for low and high frequency in NSCT domain are developed. Furthermore, a new multi-focus image fusion algorithm is proposed by combing the edge detection algorithm based on region segmentation. Perform NSCT transform on the two source images, the low frequency coefficients and high frequency coefficients are obtained, the low frequency coefficients are fused by the weighted average of sta-tistical features of local variance, local spatial frequency and sum of local modified Laplacian energy, while the high frequency coefficients are fused by local texture features; then, the preliminary fused image is ob-tained by inverse NSCT transform; finally, the clear area is identified according to the residual images of the preliminary fused image and the source images, edge of clear area is detected, and the final fused image is obtained by covering the edge information to the preliminary

  4. Diffusion-weighted magnetic resonance imaging using different b-value combinations for the evaluation of treatment results after volumetric MR-guided high-intensity focused ultrasound ablation of uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Ikink, Marlijne E.; Voogt, Marianne J.; Bosch, Maurice A.A.J. van den; Nijenhuis, Robbert J. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Keserci, Bilgin [Samsung Medical Center, High-intensity Focused Ultrasound (HIFU) Center, Seoul (Korea, Republic of); Philips Healthcare, Advanced Science and Development, Seoul (Korea, Republic of); Kim, Young-sun [Samsung Medical Center, High-intensity Focused Ultrasound (HIFU) Center, Seoul (Korea, Republic of); Samsung Medical Center, Sunkyunkwan University, Department of Radiology and Center for Imaging Science, Seoul (Korea, Republic of); Vincken, Koen L.; Bartels, Lambertus W. [University Medical Center Utrecht, Department of Radiology and Image Sciences Institute, Utrecht (Netherlands)

    2014-09-15

    To assess the value of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) mapping using different b-value combinations for treatment evaluation after magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) of uterine fibroids. Fifty-six patients with 67 uterine fibroids were treated with volumetric MR-HIFU. Pre-treatment and post-treatment images were obtained using contrast-enhanced T1-weighted MRI (CE-T1WI) and DWI using b = 0, 200, 400, 600, 800 s/mm{sup 2}. ADC maps were generated using subsets of b-values to investigate the effects of tissue ablation on water diffusion and perfusion in fibroids treated with MR-HIFU. Four combinations of b-values were used: (1) all b-values; (2) b = 0, 200 s/mm{sup 2}; (3) b = 400, 600, 800 s/mm{sup 2}; and (4) b = 0, 800 s/mm{sup 2}. Using the lowest b-values (0 and 200 s/mm{sup 2}), the mean ADC value in the ablated tissue reduced significantly (p < 0.001) compared with baseline. Calculating the ADC value with the highest b-values (400, 600, 800 s/mm{sup 2}), the ADC increased significantly (p < 0.001) post-treatment. ADC maps calculated with the lowest b-values resulted in the best visual agreement of non-perfused fibroid tissue detected on CE images. Other b-value combinations and normal myometrium showed no difference in ADC after MR-HIFU treatment. A decrease in contrast agent uptake within the ablated region on CE-T1WI was correlated to a significantly decreased ADC when b = 0 and 200 s/mm{sup 2} were used. (orig.)

  5. Evaluation of epileptogenic focus in temporal lobe: correlation between ictal brain SPECT, magnetic resonance imaging and magnetic resonance spectroscopy; Avaliacao de foco epileptogenico do lobo temporal: correlacao entre SPECT ictal, ressonancia magnetica e ressonancia magnetica com espectroscopia de protons

    Energy Technology Data Exchange (ETDEWEB)

    Diegues, Maria Elena Martins [Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, RJ (Brazil). Servico de Medicina Nuclear]. E-mail: emartyns@terra.com.br; Pellini, Marcos Pinto; Alves-Leon, Soniza Vieira [Universidade Federal, Rio de Janeiro, RJ (Brazil). Faculdade de Medicina; Domingues, Romeu Cortes [Clinica de Diagnostico por Imagem (CDPI), Rio de Janeiro, RJ (Brazil)

    2004-02-01

    The purpose of this study was to determine the degree of concordance between radiological and radioisotopic methods and, if positive, to evaluate the usefulness of ictal SPECT in the localization of the epileptogenic focus. Ictal brain SPECT, magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) were performed on six patients with refractory temporal lobe epilepsy. Ictal SPECT was performed after withdrawal of the anti-epileptogenic drugs during video-EEG monitoring, using {sup 99m}Tc-ECD, administered to patients at the time of the ictus. MRI was performed in T1, T2 and FLAIR sequences and MRS was obtained using the PRESS technique, with a single voxel positioned in both hippocampi. The statistical analysis included the determination of the values of Kappa (k), standard error (se) and significance level (p) for the lateralization of the ictal focus. The analysis of all findings was based on EEG localization of the ictal discharge, seizure duration (109-280 s; 152 s average) and time of radiotracer injection (30-262 s; 96 s average). We obtained correlated data in four patients (67 per cent) and values of k = 0.67, se = 0.38, and p 0.041. We concluded that there is a concordance between ictal SPECT, MRI and MRS data and the usefulness of the radioisotopic procedure is related to a non diagnostic EEG and when there is a discordant or misleading diagnosis after a comparative analysis of EEG and MRS. (author)

  6. Focused ion beams in biology.

    Science.gov (United States)

    Narayan, Kedar; Subramaniam, Sriram

    2015-11-01

    A quiet revolution is under way in technologies used for nanoscale cellular imaging. Focused ion beams, previously restricted to the materials sciences and semiconductor fields, are rapidly becoming powerful tools for ultrastructural imaging of biological samples. Cell and tissue architecture, as preserved in plastic-embedded resin or in plunge-frozen form, can be investigated in three dimensions by scanning electron microscopy imaging of freshly created surfaces that result from the progressive removal of material using a focused ion beam. The focused ion beam can also be used as a sculpting tool to create specific specimen shapes such as lamellae or needles that can be analyzed further by transmission electron microscopy or by methods that probe chemical composition. Here we provide an in-depth primer to the application of focused ion beams in biology, including a guide to the practical aspects of using the technology, as well as selected examples of its contribution to the generation of new insights into subcellular architecture and mechanisms underlying host-pathogen interactions.

  7. Two-Dimensional Chirp-Z Transform Imaging Algorithm for General Airborne Bistatic High Squint SAR Data Focusing%一般构型机载双站大斜视SAR二维Chirp-Z变换成像算法

    Institute of Scientific and Technical Information of China (English)

    冉金和; 李修和

    2014-01-01

    A two-dimensional Chirp-Z Transform (CZT) imaging algorithm for general bistatic high squint SAR is proposed. To deal with the serious range-azimuth cross coupling of echo signal in bistatic high squint SAR, Linear Range Walk Correction (LRWC) is performed in range frequency-azimuth time domain to correct the large LRW induced by the high squint model of platforms, and then the expression of a modified bistatic point target reference spectrum is derived. Reference Function Multiplication (RFM) is firstly performed to finish the bulk focusing. With the track decoupling formulas, phase terms of spectrum are decomposed into two independent phase terms as range-variant phase terms and azimuth-variant phase terms, and their space variances are eliminated by CZT respectively to get the focusing result. The simulation tests validate the effectiveness of the proposed imaging algorithm to focus the data of general airborne bistatic high squint SAR.%该文提出一般构型机载双站大斜视SAR的2维Chirp-Z变换(CZT)成像算法。针对双站大斜视回波信号的距离-方位向强耦合,在距离频域-方位时域校正载机大斜视引起的大距离走动,然后推导改进点目标的频谱公式。成像时,先用参考函数相乘完成回波一致聚焦,然后借助于载机轨迹解耦合公式将频谱相位分解为距离移变和方位移变的两个独立相位项,再运用CZT分别消除其空变性得到成像结果。仿真验证了该算法处理一般构型机载双站大斜视SAR回波数据的有效性。

  8. Dynamic focusing in the zebrafish beating heart

    Science.gov (United States)

    Andrés-Delgado, L.; Peralta, M.; Mercader, N.; Ripoll, J.

    2016-03-01

    Of the large amount of the animal models available for cardiac research, the zebrafish is extremely valuable due to its transparency during early stages of development. In this work a dual illumination laser sheet microscope with simultaneous dual camera imaging is used to image the beating heart at 200 fps, dynamically and selectively focusing inside the beating heart through the use of a tunable lens. This dual color dynamic focusing enables imaging with cellular resolution at unprecedented high frame rates, allowing 3D imaging of the whole beating heart of embryonic zebrafish.

  9. SU-E-J-03: Characterization of the Precision and Accuracy of a New, Preclinical, MRI-Guided Focused Ultrasound System for Image-Guided Interventions in Small-Bore, High-Field Magnets

    Energy Technology Data Exchange (ETDEWEB)

    Ellens, N [Johns Hopkins University, Baltimore, Maryland (United States); Farahani, K [National Cancer Institute, Bethesda, MD (United States)

    2015-06-15

    Purpose: MRI-guided focused ultrasound (MRgFUS) has many potential and realized applications including controlled heating and localized drug delivery. The development of many of these applications requires extensive preclinical work, much of it in small animal models. The goal of this study is to characterize the spatial targeting accuracy and reproducibility of a preclinical high field MRgFUS system for thermal ablation and drug delivery applications. Methods: The RK300 (FUS Instruments, Toronto, Canada) is a motorized, 2-axis FUS positioning system suitable for small bore (72 mm), high-field MRI systems. The accuracy of the system was assessed in three ways. First, the precision of the system was assessed by sonicating regular grids of 5 mm squares on polystyrene plates and comparing the resulting focal dimples to the intended pattern, thereby assessing the reproducibility and precision of the motion control alone. Second, the targeting accuracy was assessed by imaging a polystyrene plate with randomly drilled holes and replicating the hole pattern by sonicating the observed hole locations on intact polystyrene plates and comparing the results. Third, the practicallyrealizable accuracy and precision were assessed by comparing the locations of transcranial, FUS-induced blood-brain-barrier disruption (BBBD) (observed through Gadolinium enhancement) to the intended targets in a retrospective analysis of animals sonicated for other experiments. Results: The evenly-spaced grids indicated that the precision was 0.11 +/− 0.05 mm. When image-guidance was included by targeting random locations, the accuracy was 0.5 +/− 0.2 mm. The effective accuracy in the four rodent brains assessed was 0.8 +/− 0.6 mm. In all cases, the error appeared normally distributed (p<0.05) in both orthogonal axes, though the left/right error was systematically greater than the superior/inferior error. Conclusions: The targeting accuracy of this device is sub-millimeter, suitable for many

  10. Feasibility of real-time treatment feedback using novel filter for eliminating therapeutic ultrasound noise with high-speed ultrasonic imaging in ultrasound-guided high-intensity focused ultrasound treatment

    Science.gov (United States)

    Takagi, Ryo; Jimbo, Hayato; Iwasaki, Ryosuke; Tomiyasu, Kentaro; Yoshizawa, Shin; Umemura, Shin-ichiro

    2016-07-01

    In the conventional ultrasonic monitoring of high-intensity focused ultrasound (HIFU) treatment, a significant interval between HIFU shots is required when monitoring target tissue to avoid interference between HIFU noise and RF echo signals. In our previous study, a new filtering method to eliminate only HIFU noise while maintaining tissue signals intact was proposed, and it was shown that the thermal coagulation could be detected during simultaneous HIFU irradiation through off-line processing. In this study, the filtering method and a real-time coagulation detection algorithm were implemented in an ultrasound imaging system, whose use for sequential exposure with multiple foci was demonstrated similarly to a commercial HIFU ablation system. The coagulation was automatically detected by the proposed method during real-time simultaneous HIFU irradiation, and the HIFU exposure time was controlled according to the changes in the tissue. The results imply that ultrasonic monitoring with the filtering and detection methods is useful for true real-time detection of changes in the tissue due to thermal coagulation during HIFU exposure.

  11. Scaled signal intensity of uterine fibroids based on T2-weighted MR images: a potential objective method to determine the suitability for magnetic resonance-guided focused ultrasound surgery of uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun [CHA University, Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, Gyunggi-do (Korea, Republic of); Yoon, Sang-Wook [CHA University, Department of Diagnostic Radiology, CHA Bundang Medical Center, Sungnam-si, Gyunggi-do (Korea, Republic of); Sokolov, Amit [InSightec Ltd., Haifa (Israel)

    2015-12-15

    Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive method to treat uterine fibroids. To help determine the patient suitability for MRgFUS, we propose a new objective measure: the scaled signal intensity (SSI) of uterine fibroids in T2 weighted MR images (T2WI). Forty three uterine fibroids in 40 premenopausal women were included in this retrospective study. SSI of each fibroid was measured from the screening T2WI by standardizing its mean signal intensity to a 0-100 scale, using reference intensities of rectus abdominis muscle (0) and subcutaneous fat (100). Correlation between the SSI and the non-perfused volume (NPV) ratio (a measure for treatment success) was calculated. Pre-treatment SSI showed a significant inverse-correlation with post treatment NPV ratio (p < 0.05). When dichotomizing NPV ratio at 45 %, the optimal cut off value of the SSI was found to be 16.0. A fibroid with SSI value 16.0 or less can be expected to have optimal responses. The SSI of uterine fibroids in T2WI can be suggested as an objective parameter to help in patient selection for MRgFUS. (orig.)

  12. Automated two- and three-dimensional, fine-resolution radar imaging of rigid targets with arbitrary unknown motion

    Science.gov (United States)

    Stuff, Mark A.; Sullivan, Richard C., Jr.; Thelen, Brian J.; Werness, Susan A.

    1994-06-01

    An automated system for the SAR/ISAR imaging of rigid bodies which are undergoing arbitrarily complicated unknown motions is being developed. This system determines, from only the radar data, all observable parameters of motion, on a pulse by pulse basis. The approach makes it possible to: (1) exploit any type of relative motion: translational, rotational, two dimensional, three dimensional, deterministic, or stochastic; no prior parametric assumptions on the functional form of the motion are required; (2) require only the radar data; no ancillary motion measurement system on either the radar platform or on the target is required; (3) automatically provide all the motion information needed to form correctly scaled images, without cross range scale ambiguities; (4) make full use of all the radar data; no signals returning from a target are discarded; and (5) require a known computation time, which is not signal dependent, as all iterative processes used have known, guaranteed convergence rates.

  13. Kurtosis-based estimation of cross-range scaling factor for high-resolution inverse synthetic aperture radar imaging

    Science.gov (United States)

    Phan, An; Ng, Brian; Tran, Hai-Tan

    2016-07-01

    In automatic target recognition systems based on the use of inverse synthetic aperture radar (ISAR) images, it is essential to obtain unbiased and accurate scaled two-dimensional target images in the range-cross range domain. To accomplish this, the modulus of the target effective rotation vector, which is generally unknown for noncooperative targets, must be estimated. This letter proposes an efficient method for estimating the cross-range scaling factor and significantly improving cross-range resolution based on the second-order local polynomial Fourier transform. The estimation requires solving a series of one-dimensional optimizations of a kurtosis objective. Simulations show the proposed approach to be effective and able to accurately estimate the scaling factor in the presence of noise.

  14. Analysis of polarimetric terahertz imaging for non-destructive detection of subsurface defects in wind turbine blades

    Science.gov (United States)

    Martin, Robert Warren

    During the manufacture of wind turbine blades, internal defects can form which negatively affect their structural integrity and can lead to premature failure. These defects are often not detected before the final installation of the blades onto wind turbines in the field. The purpose of this research was to investigate the advantages of using fully-polarimetric inverse synthetic aperture radar (ISAR) terahertz imaging techniques for scanning the interior structure of the wind turbine blades in order to detect and identify any defects in the blade's internal structure before the blade leaves the manufacturer. Additionally, the research has investigated the use of the Euler parameter polarimetric transformation in improving defect detection, and increasing understanding of the scattering properties of such defects. Use of an image compositing algorithm and of the Euler parameters was found to enhance defect detection.

  15. Prime focus spectrograph: Subaru's future

    OpenAIRE

    Sugai, Hajime; Dekany, Richard G.; Ellis, Richard S.; Seiffert, Michael D.; Smith, Roger M.

    2012-01-01

    The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru’s wide field of view, which is further extended with the recently completed Wide Fie...

  16. Space Focus Lead Report

    Energy Technology Data Exchange (ETDEWEB)

    Reeves, Geoffrey D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-10

    The Space Focus team is tasked with the definition of the Space Focused Science Topics, and with the review and ranking of the CSES proposals received in all the program areas. This is achieved by dedicated meetings or a series of informal discussions and/or e-mail reviews.

  17. FOCUS: Sustainable Mathematics Successes

    Science.gov (United States)

    Mireles, Selina V.; Acee, Taylor W.; Gerber, Lindsey N.

    2014-01-01

    The FOCUS (Fundamentals of Conceptual Understanding and Success) Co-Requisite Model Intervention (FOCUS Intervention) for College Algebra was developed as part of the Developmental Education Demonstration Projects (DEDP) in Texas. The program was designed to use multiple services, courses, and best practices to support student completion of a…

  18. Focusing Automatic Code Inspections

    NARCIS (Netherlands)

    Boogerd, C.J.

    2010-01-01

    Automatic Code Inspection tools help developers in early detection of defects in software. A well-known drawback of many automatic inspection approaches is that they yield too many warnings and require a clearer focus. In this thesis, we provide such focus by proposing two methods to prioritize

  19. Planar-Focusing Cathodes

    CERN Document Server

    Lewellen, J W

    2005-01-01

    Conventional pi-mode rf photoinjectors typically use magnetic solenoids for emittance compensation. This provides independent focusing strength, but can complicate rf power feed placement, introduce asymmetries (due to coil crossovers), and greatly increase the cost of the photoinjector. Cathode-region focusing can also provide for a form of emittance compensation. Typically this method strongly couples focusing strength to the field gradient on the cathode, however, and also requires altering the longitudinal position of the cathode to change the focusing. We propose a new method for achieving cathode-region variable-strength focusing for emittance compensation. The new method reduces the coupling to the gradient on the cathode, and does not require a change in the longitudinal position of the cathode. Expected performance for an S-band system is similar to conventional solenoid-based designs. This paper presents the results of rf cavity and beam dynamics simulations of the new design.

  20. Space Group Debris Imaging Based on Sparse Sample

    Directory of Open Access Journals (Sweden)

    Zhu Jiang

    2016-02-01

    Full Text Available Space group debris imaging is difficult with sparse data in low Pulse Repetition Frequency (PRF spaceborne radar. To solve this problem in the narrow band system, we propose a method for space group debris imaging based on sparse samples. Due to the diversity of mass, density, and other factors, space group debris typically rotates at a high speed in different ways. We can obtain angular velocity through the autocorrelation function based on the diversity in the angular velocity. The scattering field usually presents strong sparsity, so we can utilize the corresponding measurement matrix to extract the data of different debris and then combine it using the sparse method to reconstruct the image. Furthermore, we can solve the Doppler ambiguity with the measurement matrix in low PRF systems and suppress some energy of other debris. Theoretical analysis confirms the validity of this methodology. Our simulation results demonstrate that the proposed method can achieve high-resolution Inverse Synthetic Aperture Radar (ISAR images of space group debris in low PRF systems.

  1. Monopulse radar 3-D imaging and application in terminal guidance radar

    Science.gov (United States)

    Xu, Hui; Qin, Guodong; Zhang, Lina

    2007-11-01

    Monopulse radar 3-D imaging integrates ISAR, monopulse angle measurement and 3-D imaging processing to obtain the 3-D image which can reflect the real size of a target, which means any two of the three measurement parameters, namely azimuth difference beam elevation difference beam and radial range, can be used to form 3-D image of 3-D object. The basic principles of Monopulse radar 3-D imaging are briefly introduced, the effect of target carriage changes(including yaw, pitch, roll and movement of target itself) on 3-D imaging and 3-D moving compensation based on the chirp rate μ and Doppler frequency f d are analyzed, and the application of monopulse radar 3-D imaging to terminal guidance radars is forecasted. The computer simulation results show that monopulse radar 3-D imaging has apparent advantages in distinguishing a target from overside interference and precise assault on vital part of a target, and has great importance in terminal guidance radars.

  2. New focused crawling algorithm

    Institute of Scientific and Technical Information of China (English)

    Su Guiyang; Li Jianhua; Ma Yinghua; Li Shenghong; Song Juping

    2005-01-01

    Focused carawling is a new research approach of search engine. It restricts information retrieval and provides search service in specific topic area. Focused crawling search algorithm is a key technique of focused crawler which directly affects the search quality. This paper first introduces several traditional topic-specific crawling algorithms, then an inverse link based topic-specific crawling algorithm is put forward. Comparison experiment proves that this algorithm has a good performance in recall, obviously better than traditional Breadth-First and Shark-Search algorithms. The experiment also proves that this algorithm has a good precision.

  3. Effect of biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging, on ultrasound-guided high-intensity focused ultrasound ablation.

    Science.gov (United States)

    Zhao, Wen-Peng; Chen, Jin-Yun; Chen, Wen-Zhi

    2015-02-01

    The aims of this study were to assess the effects of the biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging (MRI), on ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation. Thirty-five patients with 39 symptomatic uterine fibroids who underwent myomectomy or hysterectomy were enrolled. Before surgery, the uterine fibroids were subdivided into hypo-intense, iso-intense, heterogeneous hyper-intense and homogeneous hyper-intense categories based on signal intensity on T2-weighted MRI. Tissue density and moisture content were determined in post-operative samples and normal uterine tissue, the isolated uterine fibroids were subjected to USgHIFU, and the extent of ablation was measured using triphenyltetrazolium chloride. Hematoxylin and eosin staining and sirius red staining were undertaken to investigate the organizational structure of the uterine fibroids. Estrogen and progesterone receptor expression was assayed via immunohistochemical staining. The mean diameter of uterine fibroids was 6.9 ± 2.8 cm. For all uterine fibroids, the average density and moisture content were 10.7 ± 0.7 mg/mL and 75.7 ± 2.4%, respectively; and for the homogeneous hyper-intense fibroids, 10.3 ± 0.5 mg/mL and 76.6 ± 2.3%. The latter subgroup had lower density and higher moisture content compared with the other subgroups. After USgHIFU treatment, the extent of ablation of the hyper-intense fibroids was 102.7 ± 42.1 mm(2), which was significantly less than those of the hypo-intense and heterogeneous hyper-intense fibroids. Hematoxylin and eosin staining and sirius red staining revealed that the homogeneous hyper-intense fibroids had sparse collagen fibers and abundant cells. Immunohistochemistry results revealed that estrogen and progesterone receptors were highly expressed in the homogeneous hyper-intense fibroids. This study revealed that lower density, higher moisture content, sparse collagen

  4. Final focus test beam

    Energy Technology Data Exchange (ETDEWEB)

    1991-03-01

    This report discusses the following: the Final Focus Test Beam Project; optical design; magnets; instrumentation; magnetic measurement and BPM calibration; mechanical alignment and stabilization; vacuum system; power supplies; control system; radiation shielding and personnel protection; infrastructure; and administration.

  5. Focus group discussions

    CERN Document Server

    Hennink, Monique M

    2014-01-01

    The Understanding Research series focuses on the process of writing up social research. The series is broken down into three categories: Understanding Statistics, Understanding Measurement, and Understanding Qualitative Research. The books provide researchers with guides to understanding, writing, and evaluating social research. Each volume demonstrates how research should be represented, including how to write up the methodology as well as the research findings. Each volume also reviews how to appropriately evaluate published research. Focus Group Discussions addresses the challenges associated with conducting and writing focus group research. It provides detailed guidance on the practical and theoretical considerations in conducting focus group discussions including: designing the discussion guide, recruiting participants, training a field team, moderating techniques and ethical considerations. Monique Hennink describes how a methodology section is read and evaluated by others, such as journal reviewers or ...

  6. Alignment and focus of mirrored facets of a heliosat

    Energy Technology Data Exchange (ETDEWEB)

    Yellowhair, Julius E; Ho, Clifford Kuofei; Diver, Richard B; Moss, Timothy A

    2013-11-12

    Various technologies pertaining to aligning and focusing mirrored facets of a heliostat are described herein. Updating alignment and/or focus of mirrored facets is undertaken through generation of a theoretical image, wherein the theoretical image is indicative of a reflection of the target via the mirrored facets when the mirrored facets are properly aligned. This theoretical image includes reference points that are overlaid on an image of the target as reflected by the mirrored facets of the heliostat. A technician adjusts alignment/focus of a mirrored facet by causing reflected reference markings to become aligned with the reference points in the theoretical image.

  7. CLIC Final Focus Studies

    CERN Document Server

    Tomás, R; Schulte, Daniel; Zimmermann, Frank

    2006-01-01

    The CLIC final focus system has been designed based on the local compensation scheme proposed by P. Raimondi and A. Seryi. However, there exist important chromatic aberrations that deteriorate the performance of the system. This paper studies the optimization of the final focus based on the computation of the higher orders of the map using MAD-X and PTC. The use of octupole tail folding to reduce the size of the halo in the locations with aperture limitations is also discussed.

  8. Electron beam focusing system

    Energy Technology Data Exchange (ETDEWEB)

    Dikansky, N.; Nagaitsev, S.; Parkhomchuk, V.

    1997-09-01

    The high energy electron cooling requires a very cold electron beam. Thus, the electron beam focusing system is very important for the performance of electron cooling. A system with and without longitudinal magnetic field is presented for discussion. Interaction of electron beam with the vacuum chamber as well as with the background ions and stored antiprotons can cause the coherent electron beam instabilities. Focusing system requirements needed to suppress these instabilities are presented.

  9. High harmonics focusing undulator

    Energy Technology Data Exchange (ETDEWEB)

    Varfolomeev, A.A.; Hairetdinov, A.H.; Smirnov, A.V.; Khlebnikov, A.S. [Kurchatov Institute, Moscow (Russian Federation)

    1995-12-31

    It was shown in our previous work that there exist a possibility to enhance significantly the {open_quote}natural{close_quote} focusing properties of the hybrid undulator. Here we analyze the actual undulator configurations which could provide such field structure. Numerical simulations using 2D code PANDIRA were carried out and the enhanced focusing properties of the undulator were demonstrated. The obtained results provide the solution for the beam transport in a very long (short wavelength) undulator schemes.

  10. Plutonium focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  11. EDITORIAL: Focus on Plasmonics FOCUS ON PLASMONICS

    Science.gov (United States)

    Bozhevolnyi, Sergey; García-Vidal, Francisco

    2008-10-01

    Plasmonics is an emerging field in optics dealing with the so-called surface plasmons whose extraordinary properties are being both analyzed from a fundamental point of view and exploited for numerous technological applications. Surface plasmons associated with surface electron density oscillations decorating metal-dielectric interfaces were discovered by Rufus Ritchie in the 1950s. Since the seventies, the subwavelength confinement of electromagnetic fields as well as their enhancement inherent to the surface plasmon excitation has been widely used for spectroscopic purposes. Recent advances in nano-fabrication, characterization and modelling techniques have allowed unique properties of these surface electromagnetic modes to be explored with respect to subwavelength field localization and waveguiding, opening the path to truly nanoscale plasmonic optical devices. This area of investigation also has interesting links with research on photonic band gap materials and the field of optical metamaterials. Nowadays, plasmonics can be seen as a mature interdisciplinary area of research in which scientists coming from different backgrounds (chemistry, physics, optics and engineering) strive to discover and exploit new and exciting phenomena associated with surface plasmons. The already made and forthcoming discoveries will have impacts in many fields of science and technology, including not only photonics and materials science but also computation, biology and medicine, among others. This focus issue of New Journal of Physics is intended to cover all the aforementioned capabilities of surface plasmons by presenting a current overview of state-of-the-art advances achieved by the leading groups in this field of research. The below list of articles represents the first contributions to the collection and further additions will appear soon. Focus on Plasmonics Contents Nanoantenna array-induced fluorescence enhancement and reduced lifetimes Reuben M Bakker, Vladimir P Drachev

  12. Retinal imaging and image analysis

    NARCIS (Netherlands)

    Abramoff, M.D.; Garvin, Mona K.; Sonka, Milan

    2010-01-01

    Many important eye diseases as well as systemic diseases manifest themselves in the retina. While a number of other anatomical structures contribute to the process of vision, this review focuses on retinal imaging and image analysis. Following a brief overview of the most prevalent causes of blindne

  13. Decontamination & decommissioning focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  14. Focusing Vacuum Fluctuations, 2

    CERN Document Server

    Ford, L H

    2002-01-01

    The quantization of the scalar and electromagnetic fields in the presence of a parabolic mirror is further developed in the context of a geometric optics approximation. We calculate the mean squared scalar and electric fields near the focal line of a parabolic cylindrical mirror. These quantities are found to grow as inverse powers of the distance from the focus. We give a combination of analytic and numerical results for the mean squared fields. In particular, we find that the mean squared electric field can be either negative or positive, depending upon the choice of parameters. The case of a negative mean squared electric field corresponds to a repulsive Van der Waals force on an atom near the focus, and to a region of negative energy density. Similarly, a positive value corresponds to an attractive force and a possibility of atom trapping in the vicinity of the focus.

  15. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...... effectively measures the intended phenomenon (i.e., journal specialisation). Only weak correlations were found between journal re-citations and obsolescence, journal self-citations, and number of references. Conclusions. The focus factor successfully measures journal specialisation over time. Measures based...

  16. [Focused musculoskeletal sonography].

    Science.gov (United States)

    Horn, Rudolf

    2015-09-16

    Even in emergent situations, focused musculoskeletal sonography must not be overlooked. It has a place in traumatology no less valuable than its place in internal medicine. It can be used to identify traumatic joint effusions, occult fractures and fissures, joint inflammation, muscle and tendon rupture; it can differentiate soft tissue swelling, locate a foreign body, or identify the location of fractures. Focused ultrasound should be performed by the attending physician directly at the patient’s bedside, in order to answer these specific questions.

  17. A Material Focus

    DEFF Research Database (Denmark)

    Vallgårda, Anna K. A.; Sokoler, Tomas

    2009-01-01

    In this paper we build on the notion of computational composites, which hold a material perspective on computational technology. We argue that a focus on the material aspects of the technology could be a fruitful approach to achieve new expressions and to gain a new view on the technology's role...

  18. Curriculum Mapping. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2008-01-01

    This "Focus On" discusses curriculum mapping, a process that allows educators to align the curriculum both within and across grades and to ensure that the curriculum is in line with school, local, and state standards. It outlines the steps of the curriculum mapping process from planning the mapping initiative to creating and editing curriculum…

  19. Youth Leadership. IDRA Focus.

    Science.gov (United States)

    IDRA Newsletter, 1995

    1995-01-01

    This theme issue focuses on motivating young people to learn by providing leadership opportunities in school. "Coca-Cola Valued Youth Program: Assessing Progress" (Josie Danini Supik) examines the program's success. This program, which trains high-risk middle and high school students as tutors of younger children, has dramatically…

  20. Adolescent Literacy. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2009-01-01

    Evidence suggests that there is a crisis in adolescent literacy. Part of the problem is that students often receive little literacy instruction after elementary school. This "Focus On" examines the literacy instruction that adolescents need to be successful as they move on to more challenging texts in middle and high school. In addition, this…

  1. Neocortical focus: experimental view.

    Science.gov (United States)

    Timofeev, Igor; Chauvette, Sylvain; Soltani, Sara

    2014-01-01

    All brain normal or pathological activities occur in one of the states of vigilance: wake, slow-wave sleep, or REM sleep. Neocortical seizures preferentially occur during slow-wave sleep. We provide a description of neuronal behavior and mechanisms mediating such a behavior within neocortex taking place in natural states of vigilance as well as during seizures pointing to similarities and differences exhibited during sleep and seizures. A concept of epileptic focus is described using a model of cortical undercut, because in that model, the borders of the focus are well defined. In this model, as in other models of acquired epilepsy, the main factor altering excitability is deafferentation, which upregulates neuronal excitability that promotes generation of seizures. Periods of disfacilitation recorded during slow-wave sleep further upregulate neuronal excitability. It appears that the state of neurons and neuronal network in the epileptic focus produced by deafferentation are such that seizures cannot be generated there. Instead, seizures always start around the perimeter of the undercut cortex. Therefore, we define these areas as the seizure focus. In this zone, neuronal connectivity and excitability are moderately enhanced, lowering the threshold for seizure generation. © 2014 Elsevier Inc. All rights reserved.

  2. Focus on the Learner

    Institute of Scientific and Technical Information of China (English)

    CuiMin

    2004-01-01

    Language teaching is often discussed from the point of view of the teacher. Some of the ways in which teachers beliefs, goals, attitudes, and decisions influence how theyapproach of teaching have already been examined by many people. However, while learning is the goal of teaching, it is not necessarily the mirror image of teaching. Learners, too,bring to learning their own beliefs, goals, attitudes, and

  3. SPECT/CT for imaging of the spine and pelvis in clinical routine: a physician's perspective of the adoption of SPECT/CT in a clinical setting with a focus on trauma surgery

    Energy Technology Data Exchange (ETDEWEB)

    Scheyerer, Max J.; Zimmermann, Stefan M.; Osterhoff, Georg; Simmen, Hans-Peter; Werner, Clement M.L. [University Hospital Zurich, Department of Surgery, Division of Trauma Surgery, Zuerich (Switzerland); Pietsch, Carsten [University Hospital Zurich, Department of Medical Radiology, Division of Nuclear Medicine, Zurich (Switzerland)

    2014-05-15

    Injuries of the axial skeleton are an important field of work within orthopaedic surgery and traumatology. Most lesions following trauma may be diagnosed by means of conventional plain radiography, computed tomography or magnetic resonance imaging. However, for some aspects SPECT/ CT can be helpful even in a trauma setting. In particular, the combination of highly sensitive but nonspecific scintigraphy with nonsensitive but highly specific computed tomography makes it particularly useful in anatomically complex regions such as the pelvis and spine. From a trauma surgeon's point of view, the four main indications for nuclear medicine imaging are the detection of (occult) fractures, and the imaging of inflammatory bone and joint diseases, chronic diseases and postoperative complications such as instability of instrumentation or implants. The aim of the present review was to give an overview of the adoption of SPECT/CT in a clinical setting. (orig.)

  4. Focusing of electromagnetic waves

    Energy Technology Data Exchange (ETDEWEB)

    Dhayalan, V.

    1996-12-31

    The focusing of electromagnetic waves inside a slab has been examined together with two special cases in which the slab is reduced to a single interface or a single medium. To that end the exact solutions for the fields inside a layered medium have been used, given in terms of the outside current source in order to obtain the solutions for the focused electric field inside a slab. Both exact and asymptotic solutions of the problem have been considered, and the validity of the latter has been discussed. The author has developed a numerical algorithm for evaluation of the diffraction integral with special emphasis on reducing the computing time. The numerical techniques in the paper can be readily applied to evaluate similar diffraction integrals occurring e.g. in microstrip antennas. 46 refs.

  5. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    is demonstrated on a selection of general science journals and on a selection of medical journals. The reference lists of each journal are compared year by year, and the percentage of re-citations is calculated by dividing the number of re-citations with the total number of citations each year. Analysis......Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...

  6. Focus on Succes

    OpenAIRE

    Ivan Slimák; Kristina Zgodavova

    2011-01-01

    The Editor wishes to present the need and form of turning the focus of individuals and organisations to success, based on evaluating understanding of the situation, on complex improving the quality of work, production and life, and on awareness of accountability for consequences of one’s actions in the given environment and time. Understood by success is sustained financial and non-financial prosperity, whilst decisive is the evaluating process, the key element is loyalty of natural and physi...

  7. Dense Plasma Focus Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Li, Shengtai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jungman, Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes-Sterbenz, Anna Catherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-31

    The mechanisms for pinch formation in Dense Plasma Focus (DPF) devices, with the generation of high-energy ions beams and subsequent neutron production over a relatively short distance, are not fully understood. Here we report on high-fidelity 2D and 3D numerical magnetohydrodynamic (MHD) simulations using the LA-COMPASS code to study the pinch formation dynamics and its associated instabilities and neutron production.

  8. A Contemporary Image of “Masculinity” and the Role of Japanese Men’s Fashion Magazines since the 1980’s, with a Focus on “MEN’S NON-NO”

    OpenAIRE

    北方, 晴子; 大石, さおり; 木村, 拓也; 菊田, 琢也; 廉, 恵晶

    2011-01-01

    This study clarifies a contemporary image of “masculinity” since the 1980’s in Japan by analyzing the Japanese men’s fashion magazine “MEN’S NON-NO.” Media and social/social psychological behavior have played a key part in construction of “masculinity.” Until the end of this year, their features and change in them were analyzed by classifying articles in “MEN’S NON-NO” from June 1986 to December 1995. A preliminary investigation into the relation between the new image of “masculinity” and the...

  9. Particle Accelerator Focus Automation

    Directory of Open Access Journals (Sweden)

    Lopes José

    2017-08-01

    Full Text Available The Laboratório de Aceleradores e Tecnologias de Radiação (LATR at the Campus Tecnológico e Nuclear, of Instituto Superior Técnico (IST has a horizontal electrostatic particle accelerator based on the Van de Graaff machine which is used for research in the area of material characterization. This machine produces alfa (He+ and proton (H+ beams of some μA currents up to 2 MeV/q energies. Beam focusing is obtained using a cylindrical lens of the Einzel type, assembled near the high voltage terminal. This paper describes the developed system that automatically focuses the ion beam, using a personal computer running the LabVIEW software, a multifunction input/output board and signal conditioning circuits. The focusing procedure consists of a scanning method to find the lens bias voltage which maximizes the beam current measured on a beam stopper target, which is used as feedback for the scanning cycle. This system, as part of a wider start up and shut down automation system built for this particle accelerator, brings great advantages to the operation of the accelerator by turning it faster and easier to operate, requiring less human presence, and adding the possibility of total remote control in safe conditions.

  10. Particle Accelerator Focus Automation

    Science.gov (United States)

    Lopes, José; Rocha, Jorge; Redondo, Luís; Cruz, João

    2017-08-01

    The Laboratório de Aceleradores e Tecnologias de Radiação (LATR) at the Campus Tecnológico e Nuclear, of Instituto Superior Técnico (IST) has a horizontal electrostatic particle accelerator based on the Van de Graaff machine which is used for research in the area of material characterization. This machine produces alfa (He+) and proton (H+) beams of some μA currents up to 2 MeV/q energies. Beam focusing is obtained using a cylindrical lens of the Einzel type, assembled near the high voltage terminal. This paper describes the developed system that automatically focuses the ion beam, using a personal computer running the LabVIEW software, a multifunction input/output board and signal conditioning circuits. The focusing procedure consists of a scanning method to find the lens bias voltage which maximizes the beam current measured on a beam stopper target, which is used as feedback for the scanning cycle. This system, as part of a wider start up and shut down automation system built for this particle accelerator, brings great advantages to the operation of the accelerator by turning it faster and easier to operate, requiring less human presence, and adding the possibility of total remote control in safe conditions.

  11. Subsurface contaminants focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  12. Optimization of focused ion beam performance

    NARCIS (Netherlands)

    Hagen, C.W.; Kruit, P.

    2009-01-01

    The authors have analyzed how much current can be obtained in the probe of an optimized two-lens focused ion beam (FIB) system. This becomes relevant, as systems become available that have the potential to image and/or fabricate structures smaller than 10 nm. The probe current versus probe size curv

  13. GRI: focusing on the evolving violent universe

    DEFF Research Database (Denmark)

    Knodlseder, J.; von Ballmoos, P.; Frontera, F.;

    2009-01-01

    The gamma-ray imager (GRI) is a novel mission concept that will provide an unprecedented sensitivity leap in the soft gamma-ray domain by using for the first time a focusing lens built of Laue diffracting crystals. The lens will cover an energy band from 200-1,300 keV with an effective area reach...... processes in the universe....

  14. IMAGES, IMAGES, IMAGES

    Energy Technology Data Exchange (ETDEWEB)

    Marcus, A.

    1980-07-01

    The role of images of information (charts, diagrams, maps, and symbols) for effective presentation of facts and concepts is expanding dramatically because of advances in computer graphics technology, increasingly hetero-lingual, hetero-cultural world target populations of information providers, the urgent need to convey more efficiently vast amounts of information, the broadening population of (non-expert) computer users, the decrease of available time for reading texts and for decision making, and the general level of literacy. A coalition of visual performance experts, human engineering specialists, computer scientists, and graphic designers/artists is required to resolve human factors aspects of images of information. The need for, nature of, and benefits of interdisciplinary effort are discussed. The results of an interdisciplinary collaboration are demonstrated in a product for visualizing complex information about global energy interdependence. An invited panel will respond to the presentation.

  15. Rheological phenomena in focus

    CERN Document Server

    Boger, DV

    1993-01-01

    More than possibly any other scientific discipline, rheology is easily visualized and the relevant literature contains many excellent photographs of unusual and often bizarre phenomena. The present book brings together these photographs for the first time. They are supported by a full explanatory text. Rheological Phenomena in Focus will be an indispensable support manual to all those who teach rheology or have to convince colleagues of the practical relevance of the subject within an industrial setting. For those who teach fluid mechanics, the book clearly illustrates the difference be

  16. Antiproton Focus Horn

    CERN Multimedia

    1974-01-01

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet.For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  17. The Individually Focused Interview

    DEFF Research Database (Denmark)

    Clausen, Aksel Skovgaard

    2012-01-01

    In this paper, I argue—with an example—that under certain conditions replacement of audio transcriptions with a combination of simultaneously taken and jointly produced notes can be done without affecting reliability, validity, and transparency. These conditions are: (1) professional or otherwise...... relatively “strong” interviewees (interview persons: IPs) with diverse backgrounds; (2) thorough planning of the interview with well-focused themes; and (3) a thorough and repeated introduction to the interview. The omission of audio transcriptions is an obvious solution to the researcher who wants a breadth...

  18. Focus on Organic Conductors

    Directory of Open Access Journals (Sweden)

    Shinya Uji, Takehiko Mori and Toshihiro Takahashi

    2009-01-01

    Full Text Available Organic materials are usually thought of as electrical insulators. Progress in chemical synthesis, however, has brought us a rich variety of conducting organic materials, which can be classified into conducting polymers and molecular crystals. Researchers can realize highly conducting molecular crystals in charge-transfer complexes, where suitable combinations of organic electron donor or acceptor molecules with counter ions or other organic molecules provide charge carriers. By means of a kind of chemical doping, the charge-transfer complexes exhibit high electrical conductivity and, thanks to their highly crystalline nature, even superconductivity has been observed. This focus issue of Science and Technology of Advanced Materials is devoted to the research into such 'organic conductors'The first organic metal was (TTF(TCNQ, which was found in 1973 to have high conductivity at room temperature and a metal–insulator transition at low temperatures. The first organic superconductor was (TMTSF2PF6, whose superconductivity under high pressures was reported by J´erome in 1980. After these findings, the research on organic conductors exploded. Hundreds of organic conductors have been reported, among which more than one hundred exhibit superconductivity. Recently, a single-component organic conductor has been found with metallic conductivity down to low temperatures.In these organic conductors, in spite of their simple electronic structures, much new physics has arisen from the low dimensionality. Examples are charge and spin density waves, characteristic metal–insulator transitions, charge order, unconventional superconductivity, superconductor–insulator transitions, and zero-gap conductors with Dirac cones. The discovery of this new physics is undoubtedly derived from the development of many intriguing novel organic conductors. High quality single crystals are indispensable to the precise measurement of electronic states.This focus issue

  19. Time-Adjusted Internal Target Volume: A Novel Approach Focusing on Heterogeneity of Tumor Motion Based on 4-Dimensional Computed Tomography Imaging for Radiation Therapy Planning of Lung Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Nishibuchi, Ikuno [Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Department of Radiation Oncology, Hiroshima Prefectural Hospital, Hiroshima (Japan); Kimura, Tomoki, E-mail: tkkimura@hiroshima-u.ac.jp [Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Nakashima, Takeo; Ochi, Yusuke [Division of Radiation Therapy, Hiroshima University Hospital, Hiroshima (Japan); Takahashi, Ippei; Doi, Yoshiko; Kenjo, Masahiro; Kaneyasu, Yuko; Ozawa, Syuichi; Murakami, Yuji [Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan); Wadasaki, Koichi [Department of Radiation Oncology, Hiroshima Prefectural Hospital, Hiroshima (Japan); Nagata, Yasushi [Department of Radiation Oncology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima (Japan)

    2014-08-01

    Purpose: To consider nonuniform tumor motion within the internal target volume (ITV) by defining time-adjusted ITV (TTV), a volume designed to include heterogeneity of tumor existence on the basis of 4-dimensional computed tomography (4D-CT). Methods and Materials: We evaluated 30 lung cancer patients. Breath-hold CT (BH-CT) and free-breathing 4D-CT scans were acquired for each patient. The tumors were manually delineated using a lung CT window setting (window, 1600 HU; level, −300 HU). Tumor in BH-CT images was defined as gross tumor volume (GTV), and the sum of tumors in 4D-CT images was defined as ITV-4D. The TTV images were generated from the 4D-CT datasets, and the tumor existence probability within ITV-4D was calculated. We calculated the TTV{sub 80} value, which is the percentage of the volume with a tumor existence probability that exceeded 80% on ITV-4D. Several factors that affected the TTV{sub 80} value, such as the ITV-4D/GTV ratio or tumor centroid deviation, were evaluated. Results: Time-adjusted ITV images were acquired for all patients, and tumor respiratory motion heterogeneity was visualized. The median (range) ITV-4D/GTV ratio and median tumor centroid deviation were 1.6 (1.0-4.1) and 6.3 mm (0.1-30.3 mm), respectively. The median TTV{sub 80} value was 43.3% (2.9-98.7%). Strong correlations were observed between the TTV{sub 80} value and the ITV-4D/GTV ratio (R=−0.71) and tumor centroid deviation (R=−0.72). The TTV images revealed the tumor motion pattern features within ITV. Conclusions: The TTV images reflected nonuniform tumor motion, and they revealed the tumor motion pattern features, suggesting that the TTV concept may facilitate various aspects of radiation therapy planning of lung cancer while incorporating respiratory motion in the future.

  20. CERN In Focus

    CERN Multimedia

    CERN audiovisual service

    2008-01-01

    First edition 2008 of Cern in Focus. On behalf of the audiovisual team, a selection of the latest videos filmed at CERN. Every six weeks, we will bring you the latest in CERN's activities, from LHC start up to the Computing Grid, featuring the experiments and many other goings-on at CERN. The agenda of this first edition of CERN in Focus features the visit of the prime minister of Malta, Lawrence Gonzi... CMS and the final descent of the YE-1 end cap... The departure of UA1 magnets to Japan... The start up of sectors 4 and 5... And finally, in our sports round up... We'll talk about football. New in brief this month... The final bolt is in place : On 7th November, in the bowels of the LHC tunnel, CERN's Director General Robert Aymar tightened a gold-plated bolt for the last arc interconnection of sector 1-2. This symbolic gesture marks the completion of all the arc interconnections of the LHC. Last welding work: it was never going to be an easy task. On this day last year just one sector had been completed,...

  1. 3D Surface Morphology Measurement and Auto-focusing System

    Institute of Scientific and Technical Information of China (English)

    CHEN Qi; ZANG Huai-pei

    2005-01-01

    When interference microscope measures the surface rough of the micromechanical device, as soon as the work distance of interference microscope and the depth of field is shortened, the interference images become slur for the measured object if there has small interference after clear focus. The auto-focusing system is introduced into the interference microscope, the system can obtain high definition interference image rapidly,and can improve the measuring velocity and measuring precision. The system is characterized by auto-focusing range of ±150 μm, auto-focusing precision of ±0.3 μm, auto-focusing time of 4~8 s.

  2. A study on the flip angle for an optimal T1-weighted image based on the 3D-THRIVE MRI technique: Focusing on the detection of a hepatocellular carcinoma (HCC)

    Science.gov (United States)

    Dong, Kyung-Rae; Goo, Eun-Hoe; Lee, Jae-Seung; Chung, Woon-Kwan; Kim, Young-Jae

    2014-04-01

    This study examined the optimal flip angle (FA) for a T1-weighted image in the detection of a hepatocellular carcinoma (HCC). A 3D-T1-weighted high-resolution isotropic volume examination (THRIVE) technique was used to determine the dependence of the signal to noise ratio (SNR) and the contrast-to-noise ratio (CNR) on the change in FA. This study targeted 40 liver cancer patients (25 men and 15 women aged 50 to 70 years with a mean age of 60.32 ± 6.2 years) who visited this hospital to undergo an abdominal MRI examination from January to June 2013. A 3.0 Tesla MRI machine (Philips, Medical System, Achieva) and a MRI receiver coil for data reception with a 16-channel multicoil were used in this study. The THRIVE (repetition time (TR): 8.1 ms, echo time (TE): 3.7 ms, matrix: 172 × 172, slice thickness: 4 mm, gap: 2 mm, field of view (FOV): 350 mm, and band width (BW): 380.1 Hz) technique was applied as a pulse sequence. The time required for the examination was 19 seconds, and the breath-hold technique was used. Axial images were obtained at five FAs: 5, 10, 15, 20 and 25°. The signal intensities of the liver, the lesion and the background noise were measured based on the acquired images before the SNR and the CNR were calculated. To evaluate the image at the FA, we used SPSS for Windows ver. 17.0 to conduct a one-way ANOVA test. A Bonferroni test was conducted as a post-hoc test. The SNRs of the hemorrhagic HCC in the 3D-THRIVE technique were 35.50 ± 4.12, 97.00 ± 10.24, 66.09 ± 7.29, 53.84 ± 5.43, and 42.92 ± 5.11 for FAs of 5, 10, 15, 20, and 25°, respectively (p = 0.0430), whereas the corresponding CNRs were 30.50 ± 3.84, 43.00 ± 5.42, 36.54 ± 4.09, 32.30 ± 2.79, and 31.69 ± 3.21 (p = 0.0003). At a small FA of 10, the SNR and the CNR showed the highest values. As the FA was increased, the SNR and the CNR values showed a decreasing tendency. In conclusion, the optimal T1-weighted image FA should be set to 10° to detect a HCC by using the 3D

  3. EU-FP7-iMars: Analysis of Mars Multi-Resolution Images using Auto-Coregistration, Data Mining and Crowd Source Techniques: One year on with a focus on auto-DTM, auto-coregistration and citizen science.

    Science.gov (United States)

    Muller, Jan-Peter; Sidiropoulos, Panagiotis; Yershov, Vladimir; Gwinner, Klaus; van Gasselt, Stephan; Walter, Sebastian; Ivanov, Anton; Morley, Jeremy; Sprinks, James; Houghton, Robert; Bamford, Stephen; Kim, Jung-Rack

    2015-04-01

    Understanding the role of different planetary surface formation processes within our Solar System is one of the fundamental goals of planetary science research. There has been a revolution in planetary surface observations over the last 8 years, especially in 3D imaging of surface shape (down to resolutions of 10cm) and subsequent terrain correction of imagery from orbiting spacecraft. This has led to the ability to be able to overlay different epochs back to the mid-1970s, examine time-varying changes (such as impact craters, RSLs, CO2 geysers, gullies, boulder movements and a host of ice-related phenomena). Consequently we are seeing a dramatic improvement in our understanding of surface formation processes. Since January 2004 the ESA Mars Express has been acquiring global data, especially HRSC stereo (12.5-25m nadir images) with 98% coverage with images ≤100m and more than 70% useful for stereo mapping (e.g. atmosphere sufficiently clear). It has been demonstrated [Gwinner et al., 2010] that HRSC has the highest possible planimetric accuracy of ≤25m and is well co-registered with MOLA, which represents the global 3D reference frame. HRSC 3D and terrain-corrected image products therefore represent the best available 3D reference data for Mars. Recently [Gwinner et al., 2015] have shown the ability to generate mosaiced DTM and BRDF-corrected surface reflectance maps. NASA began imaging the surface of Mars, initially from flybys in the 1960s with the first orbiter with images ≤100m in the late 1970s from Viking Orbiter. The most recent orbiter to begin imaging in November 2006 is the NASA MRO which has acquired surface imagery of around 1% of the Martian surface from HiRISE (at ≈25cm) and ≈5% from CTX (≈6m) in stereo. Unfortunately, for most of these NASA images, especially MGS, MO, VO and HiRISE their accuracy of georeferencing is often worse than the quality of Mars reference data from HRSC. This reduces their value for analysing changes in time

  4. CERN in Focus

    CERN Multimedia

    CERN audiovisual service

    2008-01-01

    CERN in Focus 1ère édition. Le Service Audiovisuel vous propose un panorama des dernières vidéos tournées au CERN. En effet, toutes les six semaines, nous vous présenterons l'ensemble des activités, du démarrage du LHC à la grille de calcul, en passant par les différentes expériences. Au sommaire de cette édition, la visite du premier ministre de Malte, CMS et la derniere descente du YE-1 Le depart des aimants UA1 pour le Japon La mise en marche des secteurs 4 et 5 Et enfin, ATLAS et la descente... BREVES Dernieres soudures LHC Derniers boulonnages LHC College leman Appel a candidature Open Day

  5. Alliance-focused training.

    Science.gov (United States)

    Eubanks-Carter, Catherine; Muran, J Christopher; Safran, Jeremy D

    2015-06-01

    Alliance-focused training (AFT) aims to increase therapists' ability to recognize, tolerate, and negotiate alliance ruptures by increasing the therapeutic skills of self-awareness, affect regulation, and interpersonal sensitivity. In AFT, therapists are encouraged to draw on these skills when metacommunicating about ruptures with patients. In this article, we present the 3 main supervisory tasks of AFT: videotape analysis of rupture moments, awareness-oriented role-plays, and mindfulness training. We describe the theoretical and empirical support for each supervisory task, provide examples based on actual supervision sessions, and present feedback about the usefulness of the techniques from trainees in our program. We also note some of the challenges involved in conducting AFT and the importance of maintaining a strong supervisory alliance when using this training approach.

  6. The FOCUS trial

    DEFF Research Database (Denmark)

    Glenthøj, Louise B; Fagerlund, Birgitte; Randers, Lasse

    2015-01-01

    trial enrolling 126 patients meeting the standardised criteria of being at UHR for psychosis. Patients are recruited from psychiatric in- and outpatient facilities in the Copenhagen catchment area. Patients are randomised to one of the two treatment arms: cognitive remediation plus standard treatment...... functioning, psychosis-like symptoms, negative symptomatology, and depressive symptomatology as measured with the Personal and Social Performance Scale, Brief Psychiatric Rating Scale-Expanded Version, Scale for the Assessment of Negative Symptoms, and the Montgomery-Åsberg Depression Rating Scale. DISCUSSION......: This is the first trial to evaluate the effects of neurocognitive and social cognitive remediation in UHR patients. The FOCUS trial results will provide evidence on the effect of targeted and comprehensive cognitive rehabilitation on cognition, daily living, and symptomatology as well as long-term outcome...

  7. Focus on Succes

    Directory of Open Access Journals (Sweden)

    Ivan Slimák

    2011-10-01

    Full Text Available The Editor wishes to present the need and form of turning the focus of individuals and organisations to success, based on evaluating understanding of the situation, on complex improving the quality of work, production and life, and on awareness of accountability for consequences of one’s actions in the given environment and time. Understood by success is sustained financial and non-financial prosperity, whilst decisive is the evaluating process, the key element is loyalty of natural and physical persons, and the priority is loyalty of external customers. The address is targeted to would-be authors and readers of our Journal interested in engineering and management of quality of mutually correlate entities.

  8. Focusing on customer service.

    Science.gov (United States)

    1996-01-01

    This booklet is devoted to a consideration of how good customer service in family planning programs can generate demand for products and services, bring customers back, and reduce costs. Customer service is defined as increasing client satisfaction through continuous concern for client preferences, staff accountability to clients, and respect for the rights of clients. Issues discussed include the introduction of a customer service approach and gaining staff commitment. The experience of PROSALUD in Bolivia in recruiting appropriate staff, supervising staff, soliciting client feedback, and marketing services is offered as an example of a successful customer service approach. The key customer service functions are described as 1) establishing a welcoming atmosphere, 2) streamlining client flow, 3) personalizing client services, and 4) organizing and providing clear information to clients. The role of the manager in developing procedures is explored, and the COPE (Client-Oriented Provider-Efficient) process is presented as a good way to begin to make improvements. Techniques in staff training in customer service include brainstorming, role playing, using case studies (examples of which are provided), and engaging in practice sessions. Training also leads to the development of effective customer service attitudes, and the differences between these and organizational/staff-focused attitudes are illustrated in a chart. The use of communication skills (asking open-ended questions, helping clients express their concerns, engaging in active listening, and handling difficult situations) is considered. Good recovery skills are important when things go wrong. Gathering and using client feedback is the next topic considered. This involves identifying, recording, and discussing customer service issues as well as taking action on these issues and evaluating the results. The booklet ends by providing a sample of customer service indicators, considering the maintenance of a

  9. Optical sharper focusing in an anisotropic crystal.

    Science.gov (United States)

    Wang, Sicong; Xie, Xiangsheng; Gu, Min; Zhou, Jianying

    2015-06-01

    Optical super-resolution technique through tight focusing is a widely used technique to image material samples with anisotropic optical properties. The knowledge of the field distribution of a tightly focused beam in anisotropic media is both scientifically interesting and technologically important. In this paper, the optical properties of a uniaxial crystal with the optic axis perpendicular to the interface under a tight focusing configuration are studied with rigorous theoretical and numerical analysis. The significant effect of the Poynting vector on the focal position introduces an obvious displacement of the focal spot formed by the extraordinary waves (e-ray). Moreover, a sharper focus with a lateral size of 0.22λ is obtained as a result of the effective separation of the ordinary waves (o-ray) and the e-ray. It provides a new tool to fabricate optical structures with higher resolutions than that in an isotropic medium through the far-field method.

  10. 重视眼底相干光断层成像技术的临床应用与图像解读%Focus on clinical application of optical coherence tomography and image analysis

    Institute of Scientific and Technical Information of China (English)

    魏文斌

    2012-01-01

    Optical coherence tomography (OCT) is a non-invasive,high-resolution imaging modality to acquire cross-sections and three-dimensional images of the microstructure in biological specimens.Because of rapid improvement of acquisition speed and axial resolution of OCT over recent years,OCT is becoming increasingly used in clinic for diagnosing or analyzing diseases of the eye,especially in the fundus.However,OCT has been used regardless of the location of lesions and the clarity of optical media.This misuse wastes resources and delays diagnosis and treatment of certain ocular diseases.Furthermore,the image of SD-OCT cannot be analyzed completely at present. Therefore,how to apply OCT in clinic appropriately and to analyze its image professionally is crucial,which should attract the attention of ophthalmologists.In addition,comprehensively analyzing ocular diseases combined with other examinations is extremely important to improve the level of diagnosis.%相干光断层成像(OCT)是一种非侵入性,高分辨率的成像技术,可以获取生物组织超微结构的横截面及三维图像.随着近年来OCT检测技术的不断改进,其成像速度加快,分辨率提高,因此被广泛应用于眼科临床,尤其在眼底疾病的辅助诊断方面显示出明显的优势.但也有部分眼科医师对OCT检测的适应证掌握不严,在尚未了解患者病变部位及屈光间质是否清晰的情况下,均行OCT检查.这样不但浪费医疗资源,增加患者经济负担,甚至贻误疾病诊断.随着频域OCT检测技术的快速发展,解读OCT图像的难度也相应增加,因此需要眼科医师不断提高科学解读OCT图像的水平和能力,从而综合分析和判断患者病情.合理选择OCT检测的适应证、科学解读OCT图像是临床确诊的重要前提,应引起临床眼科工作者的高度重视.

  11. White Light Focusing Mirror

    Science.gov (United States)

    Johnson, Eric; Lyndaker, Aaron; Deyhim, Alex; Sullivan, Michael; Chance, Mark; Abel, Don; Toomey, John; Hulbert, Steven

    2007-01-01

    The NSLS X28C white-light beamline is being outfitted with a focusing mirror in order to increase, as well as control, the x-ray intensity at the sample position. The new mirror is a 50 mm × 100 mm × 1100 mm single crystal silicon cylindrical 43.1mm radius substrate bendable to a toroid from infinite to 1200 m radius. The unique feature of this mirror system is the dual use of Indalloy 51 as both a mechanism for heat transfer and a buoyant support to negate the effects of gravity. The benefit of the liquid metal support is the ability to correct for minor slope errors that take the form of a parabola. A bobber mechanism is employed to displace the fluid under the mirror +/- 1.5 mm. This allows RMS slope error correction on the order of 2 urad. The unique mounting of the mirror ensures the contributions to slope error from errant mechanical stresses due to machining tolerances are virtually non-existent. After correction, the surface figure error (measured minus ideal) is <= 0.5 urad rms.

  12. Stress wave focusing transducers

    Energy Technology Data Exchange (ETDEWEB)

    Visuri, S.R., LLNL

    1998-05-15

    Conversion of laser radiation to mechanical energy is the fundamental process behind many medical laser procedures, particularly those involving tissue destruction and removal. Stress waves can be generated with laser radiation in several ways: creation of a plasma and subsequent launch of a shock wave, thermoelastic expansion of the target tissue, vapor bubble collapse, and ablation recoil. Thermoelastic generation of stress waves generally requires short laser pulse durations and high energy density. Thermoelastic stress waves can be formed when the laser pulse duration is shorter than the acoustic transit time of the material: {tau}{sub c} = d/c{sub s} where d = absorption depth or spot diameter, whichever is smaller, and c{sub s} = sound speed in the material. The stress wave due to thermoelastic expansion travels at the sound speed (approximately 1500 m/s in tissue) and leaves the site of irradiation well before subsequent thermal events can be initiated. These stress waves, often evolving into shock waves, can be used to disrupt tissue. Shock waves are used in ophthalmology to perform intraocular microsurgery and photodisruptive procedures as well as in lithotripsy to fragment stones. We have explored a variety of transducers that can efficiently convert optical to mechanical energy. One such class of transducers allows a shock wave to be focused within a material such that the stress magnitude can be greatly increased compared to conventional geometries. Some transducer tips could be made to operate regardless of the absorption properties of the ambient media. The size and nature of the devices enable easy delivery, potentially minimally-invasive procedures, and precise tissue- targeting while limiting thermal loading. The transducer tips may have applications in lithotripsy, ophthalmology, drug delivery, and cardiology.

  13. Prime Focus Spectrograph - Subaru's future -

    CERN Document Server

    Sugai, Hajime; Takato, Naruhisa; Tamura, Naoyuki; Shimono, Atsushi; Ohyama, Youichi; Ueda, Akitoshi; Ling, Hung-Hsu; de Arruda, Marcio Vital; Barkhouser, Robert H; Bennett, Charles L; Bickerton, Steve; Braun, David F; Bruno, Robin J; Carr, Michael A; Oliveira, João Batista de Carvalho; Chang, Yin-Chang; Chen, Hsin-Yo; Dekany, Richard G; Dominici, Tania Pereira; Ellis, Richard S; Fisher, Charles D; Gunn, James E; Heckman, Timothy M; Ho, Paul T P; Hu, Yen-Shan; Jaquet, Marc; Karr, Jennifer; Kimura, Masahiko; Fèvre, Olivier Le; Mignant, David Le; Loomis, Craig; Lupton, Robert H; Madec, Fabrice; Marrara, Lucas Souza; Martin, Laurent; Murayama, Hitoshi; de Oliveira, Antonio Cesar; de Oliveira, Claudia Mendes; de Oliveira, Ligia Souza; Orndorff, Joe D; Vilaça, Rodrigo de Paiva; Macanhan, Vanessa Bawden de Paula; Prieto, Eric; Santos, Jesulino Bispo dos; Seiffert, Michael D; Smee, Stephen A; Smith, Roger M; Sodré, Laerte; Spergel, David N; Surace, Christian; Vives, Sebastien; Wang, Shiang-Yu; Yan, Chi-Hung

    2012-01-01

    The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru's wide field of view, which is further extended with the recently completed Wide Field Corrector, PFS will enable us to carry out multi-fiber spectroscopy of 2400 targets within 1.3 degree diameter. A microlens is attached at each fiber entrance for F-ratio transformation into a larger one so that difficulties of spectrograph design are eased. Fibers are accurately placed onto target positions by positioners, each of which consists of two stages of piezo-electric rotary motors, through iterations by using back-illuminated fiber position measurements with a wide-field metrology camera. Fibers then carry l...

  14. Approach focused on people

    Directory of Open Access Journals (Sweden)

    Roa Ruben

    2010-11-01

    Full Text Available Family and community medicine assumes a new epistemological landmark that also provides the use of instruments and tools related to it. This care model permits carrying out a visit where all categories which the health-disease process is expressed are present. Family Medicine intends to combine both visions and, for such, it gifts elements to incorporate disease as an essential part of our patient's approach systematic being the main focus the approach by problems, which is nothing but that which concerns the individual, his family or the physician, or all of them, and at times there will be nuisances while at other times, there will be diseases, and mil in other instances, all of them will co-exist. It is known that the impact of a health problem on an individual affects not only himself, but also his surroundings. In turn, the environment around this individual can act as the origin or perpetuator of the crisis, or else serve to help in solving the conflict. Distinct tools serve the purpose of knowing the context in which health crisis is developed, such as: genogram, individual and family vital cycle. Every time two people communicate, the agreement or disagreement generate possible variables. In the physician-patient relationship, this is no exception. Values, beliefs, feelings, and information of each individual different and physicians not necessarily in agreement in several issues during a visit. The objective is the need to achieve a minimum of agreements so that this visit has therapeutic effectiveness, thus being if/rpm -taw to find a common territory. Relations in general involve power; care, feelings, trust and goals. The objective in this type of relationship must be obviously shared ly both and cannot be any other than that of achieving, the highest level of health to our patient. So, our specialty, considered of low complexity, becomes a highly cognitive complexity, special and there is no doubt that it is a lot easier to handle

  15. EDITORIAL: Focus on Gravitational Lensing

    Science.gov (United States)

    Jain, Bhuvnesh

    2007-11-01

    Gravitational lensing emerged as an observational field following the 1979 discovery of a doubly imaged quasar lensed by a foreground galaxy. In the 1980s and '90s dozens of other multiply imaged systems were observed, as well as time delay measurements, weak and strong lensing by galaxies and galaxy clusters, and the discovery of microlensing in our galaxy. The rapid pace of advances has continued into the new century. Lensing is currently one of best techniques for finding and mapping dark matter over a wide range of scales, and also addresses broader cosmological questions such as understanding the nature of dark energy. This focus issue of New Journal of Physics presents a snapshot of current research in some of the exciting areas of lensing. It provides an occasion to look back at the advances of the last decade and ahead to the potential of the coming years. Just about a decade ago, microlensing was discovered through the magnification of stars in our galaxy by invisible objects with masses between that of Jupiter and a tenth the mass of the Sun. Thus a new component of the mass of our galaxy, dubbed MACHOs, was established (though a diffuse, cold dark matter-like component is still needed to make up most of the galaxy mass). More recently, microlensing led to another exciting discovery—of extra-solar planets with masses ranging from about five times that of Earth to that of Neptune. We can expect many more planets to be discovered through ongoing surveys. Microlensing is the best technique for finding Earth mass planets, though it is not as productive overall as other methods and does not allow for follow up observations. Beyond planet hunting, microlensing has enabled us to observe previously inaccessible systems, ranging from the surfaces of other stars to the accretion disks around the black holes powering distant quasars. Galaxies and galaxy clusters at cosmological distances can produce dramatic lensing effects: multiple images of background galaxies

  16. Fast calculation of the best focus position

    Science.gov (United States)

    Bezzubik, Vitalii; Belashenkov, Nikolai; Vdovin, Gleb

    2015-03-01

    New computational technique based on linear-scale differential analysis (LSDA) of digital image is proposed to find the best focus position in digital microscopy by means of defocus estimation in two near-focal positions only. The method is based on the calculation of local gradients of the image on different scales using its convolution with a number of differential filters of linearly varying sizes, consequent removal of noisy pixels out of consideration, and selection of pixels at the edges of objects. It is shown that the mean values of the selected gradients decrease while the scale increases thus the rate of change of these mean values of gradients unambiguously determines the magnitude of digital image defocus as a function of scale. Using this method the value and sign of defocus can be found if the result of LSDA of captured images is compared with pre-defined look-up table. The robustness of the proposed method to spatial noise is achieved by ignoring pixels that are corrupted by spatial noise within the areas of the image outside the edges of objects. Most computational operations of the method are based on integer arithmetic that simplifies its practical implementation and significantly improves the performance. The latter aspect is particularly important for practical use in real-time imaging systems.

  17. Self-focused Attention in Anorexia Nervosa

    Science.gov (United States)

    Zucker, Nancy; Wagner, H. Ryan; Merwin, Rhonda; Bulik, Cynthia M.; Moskovich, Ashley; Keeling, Lori; Hoyle, Rick

    2015-01-01

    Objective The clinical presentation of anorexia nervosa (AN) is characterized by preoccupation with body experience, intrusive concerns regarding shape, and pathological fears of weight gain. These symptoms are suggestive of unrelenting self-focused attention. No research to date has characterized self-focused attention (SFA) in AN nor examined neurocognitive features that may facilitate an excessive, rigid, or sustained focus on one’s appearance. Method This study examined SFA, body image disturbance, and executive functioning in women with current anorexia nervosa (AN-C; n = 24), a history of AN who were weight-restored at the time of the study weight-restored (WR; n = 19), and healthy controls (n = 24). Results Private and public SFA were highest among WR and lowest among AN-C. Shape concerns were negatively correlated with SFA, especially among AN-C, after controlling for depression and social anxiety symptoms. Discussion Lower levels of SFA among AN-C were unexpected and suggest the acute state of AN may lessen pathological self-focus, negatively reinforcing symptoms. In addition, body image concerns may distract from general SFA. Deficits in executive attention may explain these findings, as each one unit increase in perseverative errors among AN-C participants was associated with an almost one-half unit decrease in public SFA. PMID:24899215

  18. Task-focused modeling in automated agriculture

    Science.gov (United States)

    Vriesenga, Mark R.; Peleg, K.; Sklansky, Jack

    1993-01-01

    Machine vision systems analyze image data to carry out automation tasks. Our interest is in machine vision systems that rely on models to achieve their designed task. When the model is interrogated from an a priori menu of questions, the model need not be complete. Instead, the machine vision system can use a partial model that contains a large amount of information in regions of interest and less information elsewhere. We propose an adaptive modeling scheme for machine vision, called task-focused modeling, which constructs a model having just sufficient detail to carry out the specified task. The model is detailed in regions of interest to the task and is less detailed elsewhere. This focusing effect saves time and reduces the computational effort expended by the machine vision system. We illustrate task-focused modeling by an example involving real-time micropropagation of plants in automated agriculture.

  19. Detection, parameter estimation and imaging of maneuvering target in wide-band signal

    Institute of Scientific and Technical Information of China (English)

    LI YaChao; XING MengDao; ZHANG Long; BAO Zheng

    2009-01-01

    The signal-to-noise ratio may be increased by the cross-range coherence integration so as to detect the moving target in low signal-to-noise ratio (SNR) condition. But, the radial velocity, acceleration and the change of acceleration due to the maneuvering motion of target may induce serious range migration and crose-range high-order phase terms leading to the unfocused cross-range image, the reduction of signal-noise ratio and the invalidation of target detection. Therefore, in order to solve these problems,this paper proposes a new method based on the adjacent correlation and scale transform methods for detection, parameters estimation and imaging of maneuvering targets in wide-band signal. This method can align the range and remove the cross-range high-order phase terms induced by the radial motion of target, enabling us to detect the target and estimate its moving parameters better. Finally, the simulated target is used to confirm that the method proposed by this paper can perfectly detect the maneuvering target in low signal-to-noise ratio condition, estimate its motion parameters and obtain an ISAR image of target.

  20. Focusators for laser-branding

    Science.gov (United States)

    Doskolovich, L. L.; Kazanskiy, N. L.; Kharitonov, S. I.; Uspleniev, G. V.

    A new method is investigated for synthesis of computer-generated optical elements: focusators that are able to focus the radial-symmetrical laser beam into complex focal contours, in particular into alphanumeric symbols. The method is based on decomposition of the focal contour into segments of straight lines and semi-circles, following corresponding spacing out of the focusator on elementary segments (concentric rings or sectors) and solution of the inverse task of focusing from focusator segments into corresponding elements of the focal contour. The results of numerical computing of the field from synthesized focusators into the letters are presented. The theoretical efficiency of the focusators discussed is no less than 85%. The amplitude masks and the results of operational studies of synthesized focusators are presented.