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Sample records for fitness landscape analysis

  1. Fitness Landscape Analysis for Optimum Multiuser Detection Problem

    Institute of Scientific and Technical Information of China (English)

    WANG Shaowei; ZHU Qiuping

    2007-01-01

    Optimum multiuser detection (OMD) for CDMA systems is an NP-complete combinatorial optimization problem. Fitness landscape has been proven to be very useful for understanding the behavior of combinatorial optimization algorithms and can help in predicting their performance. This paper analyzes the statistic properties of the fitness landscape of the OMD problem by performing autocorrelation analysis, fitness distance correlation test and epistasis measure. The analysis results explain why some random search algorithms are effective methods for OMD problem and give hints how to design more efficient randomized search heuristic algorithms for OMD.

  2. An Analysis of the Fitness Landscape of Travelling Salesman Problem.

    Science.gov (United States)

    Tayarani-N, Mohammad-H; Prügel-Bennett, Adam

    2016-01-01

    The fitness landscape of the travelling salesman problem is investigated for 11 different types of the problem. The types differ in how the distances between cities are generated. Many different properties of the landscape are studied. The properties chosen are all potentially relevant to choosing an appropriate search algorithm. The analysis includes a scaling study of the time to reach a local optimum, the number of local optima, the expected probability of reaching a local optimum as a function of its fitness, the expected fitness found by local search and the best fitness, the probability of reaching a global optimum, the distance between the local optima and the global optimum, the expected fitness as a function of the distance from an optimum, their basins of attraction and a principal component analysis of the local optima. The principal component analysis shows the correlation of the local optima in the component space. We show how the properties of the principal components of the local optima change from one problem type to another.

  3. Quasispecies on Fitness Landscapes.

    Science.gov (United States)

    Schuster, Peter

    2016-01-01

    Selection-mutation dynamics is studied as adaptation and neutral drift on abstract fitness landscapes. Various models of fitness landscapes are introduced and analyzed with respect to the stationary mutant distributions adopted by populations upon them. The concept of quasispecies is introduced, and the error threshold phenomenon is analyzed. Complex fitness landscapes with large scatter of fitness values are shown to sustain error thresholds. The phenomenological theory of the quasispecies introduced in 1971 by Eigen is compared to approximation-free numerical computations. The concept of strong quasispecies understood as mutant distributions, which are especially stable against changes in mutations rates, is presented. The role of fitness neutral genotypes in quasispecies is discussed.

  4. 2-bit Flip Mutation Elementary Fitness Landscapes

    OpenAIRE

    Langdon, William

    2010-01-01

    Genetic Programming parity is not elementary. GP parity cannot be represented as the sum of a small number of elementary landscapes. Statistics, including fitness distance correlation, of Parity's fitness landscape are calculated. Using Walsh analysis the eigen values and eigenvectors of the Laplacian of the two bit flip fitness landscape are given and a ruggedness measure for elementary landscapes is proposed. An elementary needle in a haystack (NIH) landscape is g...

  5. Analysis of epistatic interactions and fitness landscapes using a new geometric approach

    Directory of Open Access Journals (Sweden)

    Elena Santiago F

    2007-04-01

    Full Text Available Abstract Background Understanding interactions between mutations and how they affect fitness is a central problem in evolutionary biology that bears on such fundamental issues as the structure of fitness landscapes and the evolution of sex. To date, analyses of fitness landscapes have focused either on the overall directional curvature of the fitness landscape or on the distribution of pairwise interactions. In this paper, we propose and employ a new mathematical approach that allows a more complete description of multi-way interactions and provides new insights into the structure of fitness landscapes. Results We apply the mathematical theory of gene interactions developed by Beerenwinkel et al. to a fitness landscape for Escherichia coli obtained by Elena and Lenski. The genotypes were constructed by introducing nine mutations into a wild-type strain and constructing a restricted set of 27 double mutants. Despite the absence of mutants higher than second order, our analysis of this genotypic space points to previously unappreciated gene interactions, in addition to the standard pairwise epistasis. Our analysis confirms Elena and Lenski's inference that the fitness landscape is complex, so that an overall measure of curvature obscures a diversity of interaction types. We also demonstrate that some mutations contribute disproportionately to this complexity. In particular, some mutations are systematically better than others at mixing with other mutations. We also find a strong correlation between epistasis and the average fitness loss caused by deleterious mutations. In particular, the epistatic deviations from multiplicative expectations tend toward more positive values in the context of more deleterious mutations, emphasizing that pairwise epistasis is a local property of the fitness landscape. Finally, we determine the geometry of the fitness landscape, which reflects many of these biologically interesting features. Conclusion A full

  6. Decision making on fitness landscapes

    Science.gov (United States)

    Arthur, R.; Sibani, P.

    2017-04-01

    We discuss fitness landscapes and how they can be modified to account for co-evolution. We are interested in using the landscape as a way to model rational decision making in a toy economic system. We develop a model very similar to the Tangled Nature Model of Christensen et al. that we call the Tangled Decision Model. This is a natural setting for our discussion of co-evolutionary fitness landscapes. We use a Monte Carlo step to simulate decision making and investigate two different decision making procedures.

  7. Decision Making on Fitness Landscapes

    DEFF Research Database (Denmark)

    Arthur, Rudy; Sibani, Paolo

    2017-01-01

    We discuss fitness landscapes and how they can be modified to account for co-evolution. We are interested in using the landscape as a way to model rational decision making in a toy economic system. We develop a model very similar to the Tangled Nature Model of Christensen et. al. that we call...... the Tangled Decision Model. This is a natural setting for our discussion of co-evolutionary fitness landscapes. We use a Monte Carlo step to simulate decision making and investigate two different decision making procedures....

  8. Descision Making on Fitness Landscapes

    CERN Document Server

    Arthur, Rudy

    2016-01-01

    We discuss fitness landscapes and how they can be modified to account for co-evolution. We are interested in using the landscape as a way to model rational decision making in a toy economic system. We develop a model very similar to the Tangled Nature Model of Christensen et. al. that we call the Tangled Decision Model. This is a natural setting for our discussion of co-evolutionary fitness landscapes. We use a Monte Carlo step to simulate decision making and investigate two different decision making procedures.

  9. Why some fitness landscapes are fractal.

    Science.gov (United States)

    Weinberger, E D; Stadler, P F

    1993-07-21

    Many biological and biochemical measurements, for example the "fitness" of a particular genome, or the binding affinity to a particular substrate, can be treated as a "fitness landscape", an assignment of numerical values to points in sequence space (or some other configuration space). As an alternative to the enormous amount of data required to completely describe such a landscape, we propose a statistical characterization, based on the properties of a random walk through the landscape and, more specifically, its autocorrelation function. Under assumptions roughly satisfied by two classes of simple model landscapes (the N-k model and the p-spin model) and by the landscape of estimated free energies of RNA secondary structures, this autocorrelation function, along with the mean and variance of individual points and the size of the landscape, completely characterize it. Having noted that these and other landscapes of estimated replication and degradation rates all have a well-defined correlation length, we propose a classification of landscapes depending on how the correlation length scales with the diameter of the landscape. The landscapes of some of the kinetic parameters of RNA molecules scale similarly to the model landscapes introduced into evolutionary studies from other fields, such as quadratic spin glasses and the traveling salesman problem, but the correlation length of RNA landscapes are considerably smaller. Nevertheless, both the model and some of the RNA landscapes satisfy a test of self-similarity proposed by Sorkin (1988).

  10. Quantitative analyses of empirical fitness landscapes

    NARCIS (Netherlands)

    Szendro, I.G.; Schenk, M.F.; Franke, J.; Krug, J.; Visser, de J.A.G.M.

    2013-01-01

    The concept of a fitness landscape is a powerful metaphor that offers insight into various aspects of evolutionary processes and guidance for the study of evolution. Until recently, empirical evidence on the ruggedness of these landscapes was lacking, but since it became feasible to construct all po

  11. Epistasis and the Structure of Fitness Landscapes: Are Experimental Fitness Landscapes Compatible with Fisher's Geometric Model?

    Science.gov (United States)

    Blanquart, François; Bataillon, Thomas

    2016-06-01

    The fitness landscape defines the relationship between genotypes and fitness in a given environment and underlies fundamental quantities such as the distribution of selection coefficient and the magnitude and type of epistasis. A better understanding of variation in landscape structure across species and environments is thus necessary to understand and predict how populations will adapt. An increasing number of experiments investigate the properties of fitness landscapes by identifying mutations, constructing genotypes with combinations of these mutations, and measuring the fitness of these genotypes. Yet these empirical landscapes represent a very small sample of the vast space of all possible genotypes, and this sample is often biased by the protocol used to identify mutations. Here we develop a rigorous statistical framework based on Approximate Bayesian Computation to address these concerns and use this flexible framework to fit a broad class of phenotypic fitness models (including Fisher's model) to 26 empirical landscapes representing nine diverse biological systems. Despite uncertainty owing to the small size of most published empirical landscapes, the inferred landscapes have similar structure in similar biological systems. Surprisingly, goodness-of-fit tests reveal that this class of phenotypic models, which has been successful so far in interpreting experimental data, is a plausible in only three of nine biological systems. More precisely, although Fisher's model was able to explain several statistical properties of the landscapes-including the mean and SD of selection and epistasis coefficients-it was often unable to explain the full structure of fitness landscapes.

  12. Nonlinear fitness landscape of a molecular pathway.

    Directory of Open Access Journals (Sweden)

    Lilia Perfeito

    2011-07-01

    Full Text Available Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity of the proteins produced can also reduce fitness, depending on the internal state and the environment of the cell. Here, we map the fitness costs of a key metabolic network, the lactose utilization pathway in Escherichia coli. We measure the growth of several regulatory lac operon mutants in different environments inducing expression of the lac genes. We find a strikingly nonlinear fitness landscape, which depends on the production rate and on the activity rate of the lac proteins. A simple fitness model of the lac pathway, based on elementary biophysical processes, predicts the growth rate of all observed strains. The nonlinearity of fitness is explained by a feedback loop: production and activity of the lac proteins reduce growth, but growth also affects the density of these molecules. This nonlinearity has important consequences for molecular function and evolution. It generates a cliff in the fitness landscape, beyond which populations cannot maintain growth. In viable populations, there is an expression barrier of the lac genes, which cannot be exceeded in any stationary growth process. Furthermore, the nonlinearity determines how the fitness of operon mutants depends on the inducer environment. We argue that fitness nonlinearities, expression barriers, and gene-environment interactions are generic features of fitness landscapes for metabolic pathways, and we discuss their implications for the evolution of regulation.

  13. Exploring the fitness landscape of poliovirus

    Science.gov (United States)

    Bianco, Simone; Acevedo, Ashely; Andino, Raul; Tang, Chao

    2012-02-01

    RNA viruses are known to display extraordinary adaptation capabilities to different environments, due to high mutation rates. Their very dynamical evolution is captured by the quasispecies concept, according to which the viral population forms a swarm of genetic variants linked through mutation, which cooperatively interact at a functional level and collectively contribute to the characteristics of the population. The description of the viral fitness landscape becomes paramount towards a more thorough understanding of the virus evolution and spread. The high mutation rate, together with the cooperative nature of the quasispecies, makes it particularly challenging to explore its fitness landscape. I will present an investigation of the dynamical properties of poliovirus fitness landscape, through both the adoption of new experimental techniques and theoretical models.

  14. Fitness Landscape Analysis for Dynamic Resource Allocation in Multiuser OFDM Based Cognitive Radio Systems

    CERN Document Server

    Huang, Dong; Leung, Cyril

    2008-01-01

    Cognitive Radio (CR) is a promising technique for improving the spectrum efficiency in future wireless network. The downlink transmission in a multiuser Orthogonal Frequency Division Modulation (MU-OFDM) based CR system is investigated. Optimal allocating transmit power, bits and subcarriers among cognitive radio users can achieve high throughput while satisfying the given quality of services (QoS) requirements. The problem of dynamic allocation of transmit power, bits and secondary users in multiuser OFDM systems is a combinatorial optimization problem and is computationally complex. Accordingly, a simple while efficient algorithm is needed. It has been shown that memetic algorithms (MAs) outperform other traditional algorithms for many combinatorial optimization problems. On the other hand, the performance of MAs is highly dependent on specific problems. In order to achieve better performance, we need to select appropriate local search method and evolutionary operators for a memetic algorithm. Fitness lands...

  15. Combinatorial vector fields and the valley structure of fitness landscapes.

    Science.gov (United States)

    Stadler, Bärbel M R; Stadler, Peter F

    2010-12-01

    Adaptive (downhill) walks are a computationally convenient way of analyzing the geometric structure of fitness landscapes. Their inherently stochastic nature has limited their mathematical analysis, however. Here we develop a framework that interprets adaptive walks as deterministic trajectories in combinatorial vector fields and in return associate these combinatorial vector fields with weights that measure their steepness across the landscape. We show that the combinatorial vector fields and their weights have a product structure that is governed by the neutrality of the landscape. This product structure makes practical computations feasible. The framework presented here also provides an alternative, and mathematically more convenient, way of defining notions of valleys, saddle points, and barriers in landscape. As an application, we propose a refined approximation for transition rates between macrostates that are associated with the valleys of the landscape.

  16. Biological evolution in a multidimensional fitness landscape.

    Science.gov (United States)

    Saakian, David B; Kirakosyan, Zara; Hu, Chin-Kun

    2012-09-01

    We considered a multiblock molecular model of biological evolution, in which fitness is a function of the mean types of alleles located at different parts (blocks) of the genome. We formulated an infinite population model with selection and mutation, and calculated the mean fitness. For the case of recombination, we formulated a model with a multidimensional fitness landscape (the dimension of the space is equal to the number of blocks) and derived a theorem about the dynamics of initially narrow distribution. We also considered the case of lethal mutations. We also formulated the finite population version of the model in the case of lethal mutations. Our models, derived for the virus evolution, are interesting also for the statistical mechanics and the Hamilton-Jacobi equation as well.

  17. Ocean acidification changes the male fitness landscape

    Science.gov (United States)

    Campbell, Anna L.; Levitan, Don R.; Hosken, David J.; Lewis, Ceri

    2016-01-01

    Sperm competition is extremely common in many ecologically important marine taxa. Ocean acidification (OA) is driving rapid changes to the marine environments in which freely spawned sperm operate, yet the consequences of OA on sperm performance are poorly understood in the context of sperm competition. Here, we investigated the impacts of OA (+1000 μatm pCO2) on sperm competitiveness for the sea urchin Paracentrotus lividus. Males with faster sperm had greater competitive fertilisation success in both seawater conditions. Similarly, males with more motile sperm had greater sperm competitiveness, but only under current pCO2 levels. Under OA the strength of this association was significantly reduced and there were male sperm performance rank changes under OA, such that the best males in current conditions are not necessarily best under OA. Therefore OA will likely change the male fitness landscape, providing a mechanism by which environmental change alters the genetic landscape of marine species. PMID:27531458

  18. Ocean acidification changes the male fitness landscape

    Science.gov (United States)

    Campbell, Anna L.; Levitan, Don R.; Hosken, David J.; Lewis, Ceri

    2016-08-01

    Sperm competition is extremely common in many ecologically important marine taxa. Ocean acidification (OA) is driving rapid changes to the marine environments in which freely spawned sperm operate, yet the consequences of OA on sperm performance are poorly understood in the context of sperm competition. Here, we investigated the impacts of OA (+1000 μatm pCO2) on sperm competitiveness for the sea urchin Paracentrotus lividus. Males with faster sperm had greater competitive fertilisation success in both seawater conditions. Similarly, males with more motile sperm had greater sperm competitiveness, but only under current pCO2 levels. Under OA the strength of this association was significantly reduced and there were male sperm performance rank changes under OA, such that the best males in current conditions are not necessarily best under OA. Therefore OA will likely change the male fitness landscape, providing a mechanism by which environmental change alters the genetic landscape of marine species.

  19. Recent advances in the theory and application of fitness landscapes

    CERN Document Server

    Engelbrecht, Andries

    2014-01-01

    This book is concerned with recent advances in fitness landscapes. The concept of fitness landscapes originates from theoretical biology and refers to a framework for analysing and visualizing the relationships between genotypes, phenotypes and fitness. These relationships lay at the centre of attempts to mathematically describe evolutionary processes and evolutionary dynamics.     The book addresses recent advances in the understanding of fitness landscapes in evolutionary biology and evolutionary computation. In the volume, experts in the field of fitness landscapes present these findings in an integrated way to make it accessible to a number of audiences: senior undergraduate and graduate students in computer science, theoretical biology, physics, applied mathematics and engineering, but also researcher looking for a reference or/and entry point into using fitness landscapes for analysing algorithms. Also practitioners wanting to employ fitness landscape techniques for evaluating bio- and nature-inspired...

  20. Reading fitness landscape diagrams through HSAB concepts

    Energy Technology Data Exchange (ETDEWEB)

    Vigneresse, Jean-Louis, E-mail: jean-louis.vigneresse@univ-lorraine.fr

    2014-10-31

    Highlights: • Qualitative information from HSAB descriptors. • 2D–3D diagrams using chemical descriptors (χ, η, ω, α) and principles (MHP, mEP, mPP). • Estimate of the energy exchange during reaction paths. • Examples from complex systems (geochemistry). - Abstract: Fitness landscapes are conceived as range of mountains, with local peaks and valleys. In terms of potential, such topographic variations indicate places of local instability or stability. The chemical potential, or electronegativity, its value changed of sign, carries similar information. In addition to chemical descriptors defined through hard-soft acid-base (HSAB) concepts and computed through density functional theory (DFT), the principles that rule chemical reactions allow the design of such landscape diagrams. The simplest diagram uses electrophilicity and hardness as coordinates. It allows examining the influence of maximum hardness or minimum electrophilicity principles. A third dimension is introduced within such a diagram by mapping the topography of electronegativity, polarizability or charge exchange. Introducing charge exchange during chemical reactions, or mapping a third parameter (f.i. polarizability) reinforces the information carried by a simple binary diagram. Examples of such diagrams are provided, using data from Earth Sciences, simple oxides or ligands.

  1. How Good Are Statistical Models at Approximating Complex Fitness Landscapes?

    Science.gov (United States)

    du Plessis, Louis; Leventhal, Gabriel E.; Bonhoeffer, Sebastian

    2016-01-01

    Fitness landscapes determine the course of adaptation by constraining and shaping evolutionary trajectories. Knowledge of the structure of a fitness landscape can thus predict evolutionary outcomes. Empirical fitness landscapes, however, have so far only offered limited insight into real-world questions, as the high dimensionality of sequence spaces makes it impossible to exhaustively measure the fitness of all variants of biologically meaningful sequences. We must therefore revert to statistical descriptions of fitness landscapes that are based on a sparse sample of fitness measurements. It remains unclear, however, how much data are required for such statistical descriptions to be useful. Here, we assess the ability of regression models accounting for single and pairwise mutations to correctly approximate a complex quasi-empirical fitness landscape. We compare approximations based on various sampling regimes of an RNA landscape and find that the sampling regime strongly influences the quality of the regression. On the one hand it is generally impossible to generate sufficient samples to achieve a good approximation of the complete fitness landscape, and on the other hand systematic sampling schemes can only provide a good description of the immediate neighborhood of a sequence of interest. Nevertheless, we obtain a remarkably good and unbiased fit to the local landscape when using sequences from a population that has evolved under strong selection. Thus, current statistical methods can provide a good approximation to the landscape of naturally evolving populations. PMID:27189564

  2. How Good Are Statistical Models at Approximating Complex Fitness Landscapes?

    Science.gov (United States)

    du Plessis, Louis; Leventhal, Gabriel E; Bonhoeffer, Sebastian

    2016-09-01

    Fitness landscapes determine the course of adaptation by constraining and shaping evolutionary trajectories. Knowledge of the structure of a fitness landscape can thus predict evolutionary outcomes. Empirical fitness landscapes, however, have so far only offered limited insight into real-world questions, as the high dimensionality of sequence spaces makes it impossible to exhaustively measure the fitness of all variants of biologically meaningful sequences. We must therefore revert to statistical descriptions of fitness landscapes that are based on a sparse sample of fitness measurements. It remains unclear, however, how much data are required for such statistical descriptions to be useful. Here, we assess the ability of regression models accounting for single and pairwise mutations to correctly approximate a complex quasi-empirical fitness landscape. We compare approximations based on various sampling regimes of an RNA landscape and find that the sampling regime strongly influences the quality of the regression. On the one hand it is generally impossible to generate sufficient samples to achieve a good approximation of the complete fitness landscape, and on the other hand systematic sampling schemes can only provide a good description of the immediate neighborhood of a sequence of interest. Nevertheless, we obtain a remarkably good and unbiased fit to the local landscape when using sequences from a population that has evolved under strong selection. Thus, current statistical methods can provide a good approximation to the landscape of naturally evolving populations.

  3. Exploring experimental fitness landscapes for chemical synthesis and property optimization.

    Science.gov (United States)

    Tibbetts, Katharine Moore; Feng, Xiao-Jiang; Rabitz, Herschel

    2017-02-08

    Optimization is a central goal in the chemical sciences, encompassing diverse objectives including synthesis yield, catalytic activity of a material, and binding efficiency of a molecule to a target protein. Considering the enormous size of chemical space and the expected large numbers of experiments necessary to search through it in any particular application, optimization in chemistry is surprisingly efficient. This good fortune has recently been explained by analysis of the fitness landscape, i.e., the functional relationship between a target objective J (e.g., percent yield, catalytic activity) and a suitable set of variables (e.g., resources such as reactant concentrations and processing conditions). Mathematical analysis has demonstrated that, upon satisfaction of reasonable physical assumptions, the fitness landscape contains no local sub-optimal "traps" that preclude identification of the globally best value of J, in a development called the "OptiChem" theorem. One of the key assumptions behind the theorem is that sufficient resources are available to achieve the posed optimization goal. This work assesses the validity of this assumption underlying the OptiChem theorem through examination of experimental data from the recent literature. In order to explore fitness landscapes in high dimensions where the landscape cannot be visualized, a high dimensional model representation (HDMR) of experimental data is used to construct a model landscape amenable to topology assessment via gradient algorithm search. This method is shown to correctly capture the trap-free topology of a four-dimensional landscape where the objective is to optimize the composition of a solid state material (subject to an elemental mole-fraction constraint) for catalytic activity towards the oxygen evolution reaction. Analysis of a six-dimensional landscape for the objective of maximizing the photoluminescence of rare-earth solid state materials subject to two elemental mole

  4. Exploring the complexity of the HIV-1 fitness landscape.

    Directory of Open Access Journals (Sweden)

    Roger D Kouyos

    Full Text Available Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles and therefore do not capture the high dimensionality characteristic of real fitness landscapes. Here we analyze large-scale fitness landscapes that are based on predictive models for in vitro replicative fitness of HIV-1. We find that these landscapes are characterized by large correlation lengths, considerable neutrality, and high ruggedness and that these properties depend only weakly on whether fitness is measured in the absence or presence of different antiretrovirals. Accordingly, adaptive processes on these landscapes depend sensitively on the initial conditions. While the relative extent to which mutations affect fitness on their own (main effects or in combination with other mutations (epistasis is a strong determinant of these properties, the fitness landscape of HIV-1 is considerably less rugged, less neutral, and more correlated than expected from the distribution of main effects and epistatic interactions alone. Overall this study confirms theoretical conjectures about the complexity of biological fitness landscapes and the importance of the high dimensionality of the genetic space in which adaptation takes place.

  5. Predictive models for population performance on real biological fitness landscapes.

    Science.gov (United States)

    Rowe, William; Wedge, David C; Platt, Mark; Kell, Douglas B; Knowles, Joshua

    2010-09-01

    Directed evolution, in addition to its principal application of obtaining novel biomolecules, offers significant potential as a vehicle for obtaining useful information about the topologies of biomolecular fitness landscapes. In this article, we make use of a special type of model of fitness landscapes-based on finite state machines-which can be inferred from directed evolution experiments. Importantly, the model is constructed only from the fitness data and phylogeny, not sequence or structural information, which is often absent. The model, called a landscape state machine (LSM), has already been used successfully in the evolutionary computation literature to model the landscapes of artificial optimization problems. Here, we use the method for the first time to simulate a biological fitness landscape based on experimental evaluation. We demonstrate in this study that LSMs are capable not only of representing the structure of model fitness landscapes such as NK-landscapes, but also the fitness landscape of real DNA oligomers binding to a protein (allophycocyanin), data we derived from experimental evaluations on microarrays. The LSMs prove adept at modelling the progress of evolution as a function of various controlling parameters, as validated by evaluations on the real landscapes. Specifically, the ability of the model to 'predict' optimal mutation rates and other parameters of the evolution is demonstrated. A modification to the standard LSM also proves accurate at predicting the effects of recombination on the evolution.

  6. Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations.

    Science.gov (United States)

    Ferretti, Luca; Schmiegelt, Benjamin; Weinreich, Daniel; Yamauchi, Atsushi; Kobayashi, Yutaka; Tajima, Fumio; Achaz, Guillaume

    2016-05-01

    Genotypic fitness landscapes are constructed by assessing the fitness of all possible combinations of a given number of mutations. In the last years, several experimental fitness landscapes have been completely resolved. As fitness landscapes are high-dimensional, simple measures of their structure are used as statistics in empirical applications. Epistasis is one of the most relevant features of fitness landscapes. Here we propose a new natural measure of the amount of epistasis based on the correlation of fitness effects of mutations. This measure has a natural interpretation, captures well the interaction between mutations and can be obtained analytically for most landscape models. We discuss how this measure is related to previous measures of epistasis (number of peaks, roughness/slope, fraction of sign epistasis, Fourier-Walsh spectrum) and how it can be easily extended to landscapes with missing data or with fitness ranks only. Furthermore, the dependence of the correlation of fitness effects on mutational distance contains interesting information about the patterns of epistasis. This dependence can be used to uncover the amount and nature of epistatic interactions in a landscape or to discriminate between different landscape models.

  7. Biophysical principles predict fitness landscapes of drug resistance.

    Science.gov (United States)

    Rodrigues, João V; Bershtein, Shimon; Li, Anna; Lozovsky, Elena R; Hartl, Daniel L; Shakhnovich, Eugene I

    2016-03-15

    Fitness landscapes of drug resistance constitute powerful tools to elucidate mutational pathways of antibiotic escape. Here, we developed a predictive biophysics-based fitness landscape of trimethoprim (TMP) resistance for Escherichia coli dihydrofolate reductase (DHFR). We investigated the activity, binding, folding stability, and intracellular abundance for a complete set of combinatorial DHFR mutants made out of three key resistance mutations and extended this analysis to DHFR originated from Chlamydia muridarum and Listeria grayi We found that the acquisition of TMP resistance via decreased drug affinity is limited by a trade-off in catalytic efficiency. Protein stability is concurrently affected by the resistant mutants, which precludes a precise description of fitness from a single molecular trait. Application of the kinetic flux theory provided an accurate model to predict resistance phenotypes (IC50) quantitatively from a unique combination of the in vitro protein molecular properties. Further, we found that a controlled modulation of the GroEL/ES chaperonins and Lon protease levels affects the intracellular steady-state concentration of DHFR in a mutation-specific manner, whereas IC50 is changed proportionally, as indeed predicted by the model. This unveils a molecular rationale for the pleiotropic role of the protein quality control machinery on the evolution of antibiotic resistance, which, as we illustrate here, may drastically confound the evolutionary outcome. These results provide a comprehensive quantitative genotype-phenotype map for the essential enzyme that serves as an important target of antibiotic and anticancer therapies.

  8. Male competition fitness landscapes predict both forward and reverse speciation.

    Science.gov (United States)

    Keagy, Jason; Lettieri, Liliana; Boughman, Janette W

    2016-01-01

    Speciation is facilitated when selection generates a rugged fitness landscape such that populations occupy different peaks separated by valleys. Competition for food resources is a strong ecological force that can generate such divergent selection. However, it is unclear whether intrasexual competition over resources that provide mating opportunities can generate rugged fitness landscapes that foster speciation. Here we use highly variable male F2 hybrids of benthic and limnetic threespine sticklebacks, Gasterosteus aculeatus Linnaeus, 1758, to quantify the male competition fitness landscape. We find that disruptive sexual selection generates two fitness peaks corresponding closely to the male phenotypes of the two parental species, favouring divergence. Most surprisingly, an additional region of high fitness favours novel hybrid phenotypes that correspond to those observed in a recent case of reverse speciation after anthropogenic disturbance. Our results reveal that sexual selection through male competition plays an integral role in both forward and reverse speciation.

  9. Retrospective landscape analysis

    DEFF Research Database (Denmark)

    Fritzbøger, Bo

    2011-01-01

    On the basis of maps from the 18th and 19th centuries, a retrospective analysis was carried out of documentary settlement and landscape data extending back to the Middle Ages with the intention of identifying and dating general structural and dynamic features of the cultural landscape in a selected...

  10. Modelling metabolic evolution on phenotypic fitness landscapes: a case study on C4 photosynthesis.

    Science.gov (United States)

    Heckmann, David

    2015-12-01

    How did the complex metabolic systems we observe today evolve through adaptive evolution? The fitness landscape is the theoretical framework to answer this question. Since experimental data on natural fitness landscapes is scarce, computational models are a valuable tool to predict landscape topologies and evolutionary trajectories. Careful assumptions about the genetic and phenotypic features of the system under study can simplify the design of such models significantly. The analysis of C4 photosynthesis evolution provides an example for accurate predictions based on the phenotypic fitness landscape of a complex metabolic trait. The C4 pathway evolved multiple times from the ancestral C3 pathway and models predict a smooth 'Mount Fuji' landscape accordingly. The modelled phenotypic landscape implies evolutionary trajectories that agree with data on modern intermediate species, indicating that evolution can be predicted based on the phenotypic fitness landscape. Future directions will have to include structural changes of metabolic fitness landscape structure with changing environments. This will not only answer important evolutionary questions about reversibility of metabolic traits, but also suggest strategies to increase crop yields by engineering the C4 pathway into C3 plants.

  11. Error Thresholds in Single-Peak Gaussian Distributed Fitness Landscapes

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Based on the Eigen and Crow-Kimura models with a single-peak fitness landscape, we propose the fitness values of all sequence types to be Gaussian distributed random variables to incorporate the effects of the fluctuations of the fitness landscapes (noise of environments) and investigate the concentration distribution and error threshold of quasispecies by performing an ensemble average within this theoretical framework. We find that a small fluctuation of the fitness landscape causes only a slight change in the concentration distribution and error threshold, which implies that the error threshold is stable against small perturbations. However, for a sizable fluctuation, quite different from the previous deterministic models, our statistical results show that the transition from quasispecies to error catastrophe is not so sharp, indicating that the error threshold is located within a certain range and has a shift toward a larger value. Our results are qualitatively in agreement with the experimental data and provide a new implication for antiviral strategies.

  12. Greedy adaptive walks on a correlated fitness landscape.

    Science.gov (United States)

    Park, Su-Chan; Neidhart, Johannes; Krug, Joachim

    2016-05-21

    We study adaptation of a haploid asexual population on a fitness landscape defined over binary genotype sequences of length L. We consider greedy adaptive walks in which the population moves to the fittest among all single mutant neighbors of the current genotype until a local fitness maximum is reached. The landscape is of the rough mount Fuji type, which means that the fitness value assigned to a sequence is the sum of a random and a deterministic component. The random components are independent and identically distributed random variables, and the deterministic component varies linearly with the distance to a reference sequence. The deterministic fitness gradient c is a parameter that interpolates between the limits of an uncorrelated random landscape (c=0) and an effectively additive landscape (c→∞). When the random fitness component is chosen from the Gumbel distribution, explicit expressions for the distribution of the number of steps taken by the greedy walk are obtained, and it is shown that the walk length varies non-monotonically with the strength of the fitness gradient when the starting point is sufficiently close to the reference sequence. Asymptotic results for general distributions of the random fitness component are obtained using extreme value theory, and it is found that the walk length attains a non-trivial limit for L→∞, different from its values for c=0 and c=∞, if c is scaled with L in an appropriate combination.

  13. Quasispecies evolution on a fitness landscape with a fluctuating peak

    Science.gov (United States)

    Nilsson, Martin; Snoad, Nigel

    2002-03-01

    A quasispecies evolving on a fitness landscape with a single peak of fluctuating height is studied. In the approximation that back mutations can be ignored, the rate equations can be solved analytically. It is shown that the error threshold on this class of dynamic landscapes is defined by the time average of the selection pressure. In the case of a periodically fluctuating fitness peak, we also study the phase shift and response amplitude of the previously documented low-pass filter effect. The special case of a small harmonic fluctuation is treated analytically.

  14. Fitness landscapes among many options under social influence.

    Science.gov (United States)

    Caiado, Camila C S; Brock, William A; Bentley, R Alexander; O'Brien, Michael J

    2016-09-21

    Cultural learning represents a novel problem in that an optimal decision depends not only on intrinsic utility of the decision/behavior but also on transparency of costs and benefits, the degree of social versus individual learning, and the relative popularity of each possible choice in a population. In terms of a fitness-landscape function, this recursive relationship means that multiple equilibria can exist. Here we use discrete-choice theory to construct a fitness-landscape function for a bi-axial decision-making map that plots the magnitude of social influence in the learning process against the costs and payoffs of decisions. Specifically, we use econometric and statistical methods to estimate not only the fitness function but also movements along the map axes. To search for these equilibria, we employ a hill-climbing algorithm that leads to the expected values of optimal decisions, which we define as peaks on the fitness landscape. We illustrate how estimation of a measure of transparency, a measure of social influence, and the associated fitness landscape can be accomplished using panel data sets. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. M.V. Volkenstein, evolutionary thinking and the structure of fitness landscapes.

    Science.gov (United States)

    Conrad, M; Ebeling, W

    1992-01-01

    High dimensional fitness landscapes are robustly dominated by saddle points, not isolated peaks. We present an argument to this effect that is reminiscent of May's complexity stability analysis and trace out the significance for the dynamics of speciation, the connection between the neutral and punctuated aspects of evolution and evolution on moving landscapes. The paper is written in honor of M.V. Volkenstein (October 23rd, 1912-February 18th, 1992), who devoted his last papers to uniting dynamics with evolutionary thinking.

  16. Length of adaptive walk on uncorrelated and correlated fitness landscapes.

    Science.gov (United States)

    Seetharaman, Sarada; Jain, Kavita

    2014-09-01

    We consider the adaptation dynamics of an asexual population that walks uphill on a rugged fitness landscape which is endowed with a large number of local fitness peaks. We work in a parameter regime where only those mutants that are a single mutation away are accessible, as a result of which the population eventually gets trapped at a local fitness maximum and the adaptive walk terminates. We study how the number of adaptive steps taken by the population before reaching a local fitness peak depends on the initial fitness of the population, the extreme value distribution of the beneficial mutations, and correlations among the fitnesses. Assuming that the relative fitness difference between successive steps is small, we analytically calculate the average walk length for both uncorrelated and correlated fitnesses in all extreme value domains for a given initial fitness. We present numerical results for the model where the fitness differences can be large and find that the walk length behavior differs from that in the former model in the Fréchet domain of extreme value theory. We also discuss the relevance of our results to microbial experiments.

  17. Error Thresholds in Single-Peak Gaussian Distributed Fitness Landscapes

    Science.gov (United States)

    Feng, Xiao-Li; Gu, Jian-Zhong; Li, Yu-Xiao; Zhuo, Yi-Zhong

    2007-10-01

    Based on the Eigen and Crow-Kimura models with a single-peak fitness landscape, we propose the fitness values of all sequence types to be Gaussian distributed random variables to incorporate the effects of the fluctuations of the fitness landscapes (noise of environments) and investigate the concentration distribution and error threshold of quasispecies by performing an ensemble average within this theoretical framework. We find that a small fluctuation of the fitness landscape causes only a slight change in the concentration distribution and error threshold, which implies that the error threshold is stable against small perturbations. However, for a sizable fluctuation, quite different from the previous deterministic models, our statistical results show that the transition from quasi-species to error catastrophe is not so sharp, indicating that the error threshold is located within a certain range and has a shift toward a larger value. Our results are qualitatively in agreement with the experimental data and provide a new implication for antiviral strategies.

  18. Fitness landscapes, memetic algorithms, and greedy operators for graph bipartitioning.

    Science.gov (United States)

    Merz, P; Freisleben, B

    2000-01-01

    The fitness landscape of the graph bipartitioning problem is investigated by performing a search space analysis for several types of graphs. The analysis shows that the structure of the search space is significantly different for the types of instances studied. Moreover, with increasing epistasis, the amount of gene interactions in the representation of a solution in an evolutionary algorithm, the number of local minima for one type of instance decreases and, thus, the search becomes easier. We suggest that other characteristics besides high epistasis might have greater influence on the hardness of a problem. To understand these characteristics, the notion of a dependency graph describing gene interactions is introduced. In particular, the local structure and the regularity of the dependency graph seems to be important for the performance of an algorithm, and in fact, algorithms that exploit these properties perform significantly better than others which do not. It will be shown that a simple hybrid multi-start local search exploiting locality in the structure of the graphs is able to find optimum or near optimum solutions very quickly. However, if the problem size increases or the graphs become unstructured, a memetic algorithm (a genetic algorithm incorporating local search) is shown to be much more effective.

  19. Exploring NK Fitness Landscapes Using an Imitative Learning Search

    CERN Document Server

    Fontanari, José F

    2015-01-01

    The idea that a group of cooperating agents can solve problems more efficiently than when those agents work independently is hardly controversial, despite the little quantitative groundwork to support it. Here we investigate the performance of a group of agents in locating the global maxima of NK fitness landscapes with varying degrees of ruggedness. Cooperation is taken into account through imitative learning and the broadcasting of messages informing on the fitness of each agent. We find a trade-off between the group size and the frequency of imitation: for rugged landscapes, too much imitation or too large a group yield a performance poorer than that of independent agents. By decreasing the diversity of the group, imitative learning may lead to duplication of work and hence to a decrease of its effective size. However, when the parameters are set to optimal values the cooperative group substantially outperforms the independent agents.

  20. The Structure of Fitness Landscapes in Antibiotic-Resistant Bacteria

    Science.gov (United States)

    Deris, Barrett; Kim, Minsu; Zhang, Zhongge; Okano, Hiroyuki; Hermsen, Rutger; Gore, Jeff; Hwa, Terence

    2014-03-01

    To predict the emergence of antibiotic resistance, quantitative relations must be established between the fitness of drug-resistant organisms and the molecular mechanisms conferring resistance. We have investigated E. coli strains expressing resistance to translation-inhibiting antibiotics. We show that resistance expression and drug inhibition are linked in a positive feedback loop arising from an innate, global effect of drug-inhibited growth on gene expression. This feedback leads generically to plateau-shaped fitness landscapes and concomitantly, for strains expressing at least moderate degrees of drug resistance, gives rise to an abrupt drop in growth rates of cultures at threshold drug concentrations. A simple quantitative model of bacterial growth based on this innate feedback accurately predicts experimental observations without ad hoc parameter fitting. We describe how drug-inhibited growth rate and the threshold drug concentration (the minimum inhibitory concentration, or MIC) depend on the few biochemical parameters that characterize the molecular details of growth inhibition and drug resistance (e.g., the drug-target dissociation constant). And finally, we discuss how these parameters can shape fitness landscapes to determine evolutionary dynamics and evolvability.

  1. Evolution and extinction dynamics in rugged fitness landscapes

    CERN Document Server

    Brandt, P S M; Brandt, Paolo Sibani Michael; Alstroem, Preben

    1997-01-01

    Macroevolution is considered as a problem of stochastic dynamics in a system with many competing agents. Evolutionary events (speciations and extinctions) are triggered by fitness records found by random exploration of the agents' fitness landscapes. As a consequence, the average fitness in the system increases logarithmically with time, while the rate of extinction steadily decreases. This dynamics is studied by numerical simulations and, in a simpler mean field version, analytically. We also study the effect of externally added `mass' extinctions. The predictions for various quantities of paleontological interest (life-time distributions, distribution of event sizes and behavior of the rate of extinction) are robust and in good agreement with available data. Brief version of parts of this work have been published as Letters. (PRL 75, 2055, (1995) and PRL, 79, 1413, (1997))

  2. Analyzing the Interdependence Between Some Certain Gene Loci by Epistasis Measures in Fitness Landscapes of Schemata

    Institute of Scientific and Technical Information of China (English)

    李建武; 李敏强

    2003-01-01

    GA-hardness and interdependence between genes in the chromosome are important questions in the study of genetic algorithms(GA). Traditional methods, which are used to measure the interaction between genes, can only reflect the extent of epistasis between all genes in the chromosome. Therefore, the definition of the fitness landscape of schemata is proposed in this paper, and epistasis measures on this landscape of schemata are used to analyze the degree of interdependence between some certain gene loci in study. Some information between these sites can be reflected by some characters of the fitness landscape of schemata which are composed of these fixed sites. The stronger the interaction between these sites, the larger the variation of the fitness of schemata whose fixed sites correspond to those sites in study, and the more rugged the fitness landscape of these schemata. According to the degree of interaction between these given gene loci, building blocks of GA can be analyzed and determined, and further genetic operators and the structure of GA can be designed and adjusted to improve the performance of GA. At last, a lot of experiments including NK-models are done, and results of empirical analysis show that this method is effective.

  3. Direct Calculation of Protein Fitness Landscapes through Computational Protein Design.

    Science.gov (United States)

    Au, Loretta; Green, David F

    2016-01-01

    Naturally selected amino-acid sequences or experimentally derived ones are often the basis for understanding how protein three-dimensional conformation and function are determined by primary structure. Such sequences for a protein family comprise only a small fraction of all possible variants, however, representing the fitness landscape with limited scope. Explicitly sampling and characterizing alternative, unexplored protein sequences would directly identify fundamental reasons for sequence robustness (or variability), and we demonstrate that computational methods offer an efficient mechanism toward this end, on a large scale. The dead-end elimination and A(∗) search algorithms were used here to find all low-energy single mutant variants, and corresponding structures of a G-protein heterotrimer, to measure changes in structural stability and binding interactions to define a protein fitness landscape. We established consistency between these algorithms with known biophysical and evolutionary trends for amino-acid substitutions, and could thus recapitulate known protein side-chain interactions and predict novel ones.

  4. Identifying Features of Fitness Landscapes and Relating Them to Problem Difficulty.

    Science.gov (United States)

    Moser, I; Gheorghita, M; Aleti, A

    2016-02-29

    Complex combinatorial problems are most often optimised with heuristic solvers, which usually deliver acceptable results without any indication of the quality obtained. Recently, predictive diagnostic optimisation was proposed as a means of characterising the fitness landscape while optimising a combinatorial problem. The scalars produced by predictive diagnostic optimisation appear to describe the difficulty of the problem with relative reliability. In this study, we record more scalars that may be helpful in determining problem difficulty during the optimisation process and analyse these in combination with other well-known landscape descriptors by using exploratory factor analysis on four landscapes that arise from different search operators, applied to a varied set of quadratic assignment problem instances. Factors are designed to capture properties by combining the collinear variances of several variables. The extracted factors can be interpreted as the features of landscapes detected by the variables, but disappoint in their weak correlations with the result quality achieved by the optimiser, which we regard as the most reliable indicator of difficulty available. It appears that only the prediction error of predictive diagnostic optimisation has a strong correlation with the quality of the results produced, followed by a medium correlation of the fitness distance correlation of the local optima.

  5. Smoothing representation of fitness landscapes the genotype-phenotype map of evolution

    CERN Document Server

    Asselmeyer, T; Rosé, H; Asselmeyer, Torsten; Ebeling, Werner; Rose, Helge

    1995-01-01

    We investigate an simple evolutionary game of sequences and demonstrate on this example the structure of fitness landscapes in discrete problems. We show the smoothing action of the genotype-phenotype mapping which still makes it feasible for evolution to work. Further we propose the density of sequence states as a classifying measure of fitness landscapes.

  6. Intrusive rocks viewed from fitness landscape diagrams: Evolution and immiscibility

    Science.gov (United States)

    Vigneresse, J. D.

    2011-12-01

    We introduce the hard-soft acid-base concepts to magma evolution. Those concepts and their derived chemical parameters provide a new insight into mantle- and continental-derived magmas. Hence magma evolution represents a free suite of chemical reactions, thus showing natural chemical trends. They should be controlled by the principles of maximum hardness and minimum electrophilicity that rule chemical reactions. When plotting into a fitness landscape diagram, rocks suites define two major tendencies. Mantle-derived rocks present all character of an closed chemical system. Conversely, rocks contaminated within the continental crust define two other trends, depending on whether they have affinities toward a silica pole or an alkaline one. They both show the character of an open chemical system. When plotting major igneous minerals onto that diagram shows the importance of olivine, silica and alkali-bearing oxides. It points to the development of immiscibility, depending on the path along which magmas evolve. It thus provides explanation to experimentally observed immiscibility.

  7. Inclusion of the fitness sharing technique in an evolutionary algorithm to analyze the fitness landscape of the genetic code adaptability.

    Science.gov (United States)

    Santos, José; Monteagudo, Ángel

    2017-03-27

    The canonical code, although prevailing in complex genomes, is not universal. It was shown the canonical genetic code superior robustness compared to random codes, but it is not clearly determined how it evolved towards its current form. The error minimization theory considers the minimization of point mutation adverse effect as the main selection factor in the evolution of the code. We have used simulated evolution in a computer to search for optimized codes, which helps to obtain information about the optimization level of the canonical code in its evolution. A genetic algorithm searches for efficient codes in a fitness landscape that corresponds with the adaptability of possible hypothetical genetic codes. The lower the effects of errors or mutations in the codon bases of a hypothetical code, the more efficient or optimal is that code. The inclusion of the fitness sharing technique in the evolutionary algorithm allows the extent to which the canonical genetic code is in an area corresponding to a deep local minimum to be easily determined, even in the high dimensional spaces considered. The analyses show that the canonical code is not in a deep local minimum and that the fitness landscape is not a multimodal fitness landscape with deep and separated peaks. Moreover, the canonical code is clearly far away from the areas of higher fitness in the landscape. Given the non-presence of deep local minima in the landscape, although the code could evolve and different forces could shape its structure, the fitness landscape nature considered in the error minimization theory does not explain why the canonical code ended its evolution in a location which is not an area of a localized deep minimum of the huge fitness landscape.

  8. Effect of Host Species on Topography of the Fitness Landscape for a Plant RNA Virus

    Science.gov (United States)

    Cervera, Héctor; Lalić, Jasna

    2016-01-01

    ABSTRACT Adaptive fitness landscapes are a fundamental concept in evolutionary biology that relate the genotypes of individuals to their fitness. In the end, the evolutionary fate of evolving populations depends on the topography of the landscape, that is, the numbers of accessible mutational pathways and possible fitness peaks (i.e., adaptive solutions). For a long time, fitness landscapes were only theoretical constructions due to a lack of precise information on the mapping between genotypes and phenotypes. In recent years, however, efforts have been devoted to characterizing the properties of empirical fitness landscapes for individual proteins or for microbes adapting to artificial environments. In a previous study, we characterized the properties of the empirical fitness landscape defined by the first five mutations fixed during adaptation of tobacco etch potyvirus (TEV) to a new experimental host, Arabidopsis thaliana. Here we evaluate the topography of this landscape in the ancestral host Nicotiana tabacum. By comparing the topographies of the landscapes for the two hosts, we found that some features remained similar, such as the existence of fitness holes and the prevalence of epistasis, including cases of sign and reciprocal sign epistasis that created rugged, uncorrelated, and highly random topographies. However, we also observed significant differences in the fine-grained details between the two landscapes due to changes in the fitness and epistatic interactions of some genotypes. Our results support the idea that not only fitness tradeoffs between hosts but also topographical incongruences among fitness landscapes in alternative hosts may contribute to virus specialization. IMPORTANCE Despite its importance for understanding virus evolutionary dynamics, very little is known about the topography of virus adaptive fitness landscapes, and even less is known about the effects that different host species and environmental conditions may have on this

  9. Self-organization and competition in evolution: a conceptual problem in the use of fitness landscapes.

    Science.gov (United States)

    Jongeling, T B

    1996-02-21

    Recently it has been claimed that certain macroevolutionary patterns, such as the contrast between the Cambrian explosion and the Permian quiescence, can be explained as generic properties of selection processes, i.e. as features that are not caused by specific selection pressures, but that are to be expected in any selection process. The explanations are based on models of motions on randomly generated fitness landscapes, which are assumed to be representative of fitness landscapes in general. In this paper I show that such explanations of macroevolutionary patterns are conceptually flawed. If the concept of fitness used in the model is not the customary biological notion of fitness, there is no reason why organisms with higher fitness should displace organisms with lower fitness, and as a result the motion of a point representing a population is no longer determined by the shape of the fitness landscape. Nothing can be derived about the motions on the landscape, and the explanation collapses. If the model is based on the customary fitness concept, non-competing species have to be assigned the same fitnesses. As most species belonging to a radiation such as the Cambrian explosion are assumed to coexist, the majority of species will have the same fitness. A radiation of species can therefore not be modeled meaningfully on a fitness landscape.

  10. On Eigen's Quasispecies Model, Two-Valued Fitness Landscapes, and Isometry Groups Acting on Finite Metric Spaces.

    Science.gov (United States)

    Semenov, Yuri S; Novozhilov, Artem S

    2016-05-01

    A two-valued fitness landscape is introduced for the classical Eigen's quasispecies model. This fitness landscape can be considered as a direct generalization of the so-called single- or sharply peaked landscape. A general, non-permutation invariant quasispecies model is studied, and therefore the dimension of the problem is [Formula: see text], where N is the sequence length. It is shown that if the fitness function is equal to [Formula: see text] on a G-orbit A and is equal to w elsewhere, then the mean population fitness can be found as the largest root of an algebraic equation of degree at most [Formula: see text]. Here G is an arbitrary isometry group acting on the metric space of sequences of zeroes and ones of the length N with the Hamming distance. An explicit form of this exact algebraic equation is given in terms of the spherical growth function of the G-orbit A. Motivated by the analysis of the two-valued fitness landscapes, an abstract generalization of Eigen's model is introduced such that the sequences are identified with the points of a finite metric space X together with a group of isometries acting transitively on X. In particular, a simplicial analog of the original quasispecies model is discussed, which can be considered as a mathematical model of the switching of the antigenic variants for some bacteria.

  11. A framework for inferring fitness landscapes of patient-derived viruses using quasispecies theory.

    Science.gov (United States)

    Seifert, David; Di Giallonardo, Francesca; Metzner, Karin J; Günthard, Huldrych F; Beerenwinkel, Niko

    2015-01-01

    Fitness is a central quantity in evolutionary models of viruses. However, it remains difficult to determine viral fitness experimentally, and existing in vitro assays can be poor predictors of in vivo fitness of viral populations within their hosts. Next-generation sequencing can nowadays provide snapshots of evolving virus populations, and these data offer new opportunities for inferring viral fitness. Using the equilibrium distribution of the quasispecies model, an established model of intrahost viral evolution, we linked fitness parameters to the composition of the virus population, which can be estimated by next-generation sequencing. For inference, we developed a Bayesian Markov chain Monte Carlo method to sample from the posterior distribution of fitness values. The sampler can overcome situations where no maximum-likelihood estimator exists, and it can adaptively learn the posterior distribution of highly correlated fitness landscapes without prior knowledge of their shape. We tested our approach on simulated data and applied it to clinical human immunodeficiency virus 1 samples to estimate their fitness landscapes in vivo. The posterior fitness distributions allowed for differentiating viral haplotypes from each other, for determining neutral haplotype networks, in which no haplotype is more or less credibly fit than any other, and for detecting epistasis in fitness landscapes. Our implemented approach, called QuasiFit, is available at http://www.cbg.ethz.ch/software/quasifit.

  12. Analysis of NK-xor landscapes

    NARCIS (Netherlands)

    Kemenade, C.H.M. van

    1998-01-01

    The NK-xor landscapes are a class of optimization problems with adjustable ruggedness of its fitness landscape. There is no specific preference for either a 0 or a 1 value at any of the loci and The optimal value for each of the loci is dependent upon a $k$-neighbourhood of this locus. A set of the

  13. LANDSCAPE ANALYSIS METHOD OF RIVERINE TERRITORIES

    OpenAIRE

    Fedoseeva O. S.

    2013-01-01

    The article proposes a method for landscape area analysis, which consists of four stages. Technique is proposed as a tool for the practical application of pre-project research materials in the design solutions for landscape areas planning and organization

  14. Energy landscape analysis of neuroimaging data

    CERN Document Server

    Ezaki, Takahiro; Ohzeki, Masayuki; Masuda, Naoki

    2016-01-01

    Computational neuroscience models have been used for understanding neural dynamics in the brain and how they may be altered when physiological or other conditions change. We review and develop a data-driven approach to neuroimaging data called the energy landscape analysis. The methods are rooted in statistical physics theory, in particular, the Ising model, also known as the (pairwise) maximum entropy model and Boltzmann machine. The methods have been applied to fitting electrophysiological data in neuroscience for a decade, but its use in neuroimaging data is still in its infancy. We first review the methods and discuss some algorithms and technical aspects. Then, we apply the methods to functional magnetic resonance imaging data recorded from healthy individuals to inspect the relationship between the accuracy of fitting, the size of the brain system to be analyzed, and the data length.

  15. Energy landscape analysis of neuroimaging data

    Science.gov (United States)

    Ezaki, Takahiro; Watanabe, Takamitsu; Ohzeki, Masayuki; Masuda, Naoki

    2017-05-01

    Computational neuroscience models have been used for understanding neural dynamics in the brain and how they may be altered when physiological or other conditions change. We review and develop a data-driven approach to neuroimaging data called the energy landscape analysis. The methods are rooted in statistical physics theory, in particular the Ising model, also known as the (pairwise) maximum entropy model and Boltzmann machine. The methods have been applied to fitting electrophysiological data in neuroscience for a decade, but their use in neuroimaging data is still in its infancy. We first review the methods and discuss some algorithms and technical aspects. Then, we apply the methods to functional magnetic resonance imaging data recorded from healthy individuals to inspect the relationship between the accuracy of fitting, the size of the brain system to be analysed and the data length. This article is part of the themed issue `Mathematical methods in medicine: neuroscience, cardiology and pathology'.

  16. Adaptation in tunably rugged fitness landscapes: the rough Mount Fuji model.

    Science.gov (United States)

    Neidhart, Johannes; Szendro, Ivan G; Krug, Joachim

    2014-10-01

    Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of empirical evidence shows that real fitness landscapes, while possessing a considerable amount of ruggedness, are smoother than predicted by the MLM. In the present article we propose and analyze a simple fitness landscape model with tunable ruggedness based on the rough Mount Fuji (RMF) model originally introduced by Aita et al. in the context of protein evolution. We provide a comprehensive collection of results pertaining to the topographical structure of RMF landscapes, including explicit formulas for the expected number of local fitness maxima, the location of the global peak, and the fitness correlation function. The statistics of single and multiple adaptive steps on the RMF landscape are explored mainly through simulations, and the results are compared to the known behavior in the MLM model. Finally, we show that the RMF model can explain the large number of second-step mutations observed on a highly fit first-step background in a recent evolution experiment with a microvirid bacteriophage.

  17. Quantitative Description of a Protein Fitness Landscape Based on Molecular Features.

    Science.gov (United States)

    Meini, María-Rocío; Tomatis, Pablo E; Weinreich, Daniel M; Vila, Alejandro J

    2015-07-01

    Understanding the driving forces behind protein evolution requires the ability to correlate the molecular impact of mutations with organismal fitness. To address this issue, we employ here metallo-β-lactamases as a model system, which are Zn(II) dependent enzymes that mediate antibiotic resistance. We present a study of all the possible evolutionary pathways leading to a metallo-β-lactamase variant optimized by directed evolution. By studying the activity, stability and Zn(II) binding capabilities of all mutants in the preferred evolutionary pathways, we show that this local fitness landscape is strongly conditioned by epistatic interactions arising from the pleiotropic effect of mutations in the different molecular features of the enzyme. Activity and stability assays in purified enzymes do not provide explanatory power. Instead, measurement of these molecular features in an environment resembling the native one provides an accurate description of the observed antibiotic resistance profile. We report that optimization of Zn(II) binding abilities of metallo-β-lactamases during evolution is more critical than stabilization of the protein to enhance fitness. A global analysis of these parameters allows us to connect genotype with fitness based on quantitative biochemical and biophysical parameters.

  18. Quantitative Description of a Protein Fitness Landscape Based on Molecular Features

    Science.gov (United States)

    Meini, María-Rocío; Tomatis, Pablo E.; Weinreich, Daniel M.; Vila, Alejandro J.

    2015-01-01

    Understanding the driving forces behind protein evolution requires the ability to correlate the molecular impact of mutations with organismal fitness. To address this issue, we employ here metallo-β-lactamases as a model system, which are Zn(II) dependent enzymes that mediate antibiotic resistance. We present a study of all the possible evolutionary pathways leading to a metallo-β-lactamase variant optimized by directed evolution. By studying the activity, stability and Zn(II) binding capabilities of all mutants in the preferred evolutionary pathways, we show that this local fitness landscape is strongly conditioned by epistatic interactions arising from the pleiotropic effect of mutations in the different molecular features of the enzyme. Activity and stability assays in purified enzymes do not provide explanatory power. Instead, measurement of these molecular features in an environment resembling the native one provides an accurate description of the observed antibiotic resistance profile. We report that optimization of Zn(II) binding abilities of metallo-β-lactamases during evolution is more critical than stabilization of the protein to enhance fitness. A global analysis of these parameters allows us to connect genotype with fitness based on quantitative biochemical and biophysical parameters. PMID:25767204

  19. Baldwin effect under multipeaked fitness landscapes: Phenotypic fluctuation accelerates evolutionary rate

    Science.gov (United States)

    Saito, Nen; Ishihara, Shuji; Kaneko, Kunihiko

    2013-05-01

    Phenotypic fluctuations and plasticity can generally affect the course of evolution, a process known as the Baldwin effect. Several studies have recast this effect and claimed that phenotypic plasticity accelerates evolutionary rate (the Baldwin expediting effect); however, the validity of this claim is still controversial. In this study, we investigate the evolutionary population dynamics of a quantitative genetic model under a multipeaked fitness landscape, in order to evaluate the validity of the effect. We provide analytical expressions for the evolutionary rate and average population fitness. Our results indicate that under a multipeaked fitness landscape, phenotypic fluctuation always accelerates evolutionary rate, but it decreases the average fitness. As an extreme case of the trade-off between the rate of evolution and average fitness, phenotypic fluctuation is shown to accelerate the error catastrophe, in which a population fails to sustain a high-fitness peak. In the context of our findings, we discuss the role of phenotypic plasticity in adaptive evolution.

  20. Quasispecies theory for multiple-peak fitness landscapes

    Science.gov (United States)

    Munoz, Enrique; Saakian, David; Hu, Chin-Kun; Deem, Michael

    2007-03-01

    We used a path integral representation to solve the Eigen and Crow-Kimura molecular evolution models for the case of multiple fitness peaks with arbitrary fitness and degradation functions. In the general case, we find that the solution to these molecular evolution models can be written as the optimum of a fitness function, with constraints enforced by Lagrange multipliers and with a term accounting for the entropy of the spreading population in sequence space. The results for the Eigen model are applied to consider virus or cancer proliferation under the control of drugs or the immune system.

  1. Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.

    Directory of Open Access Journals (Sweden)

    Daniel J Kvitek

    2011-04-01

    Full Text Available The fitness landscape captures the relationship between genotype and evolutionary fitness and is a pervasive metaphor used to describe the possible evolutionary trajectories of adaptation. However, little is known about the actual shape of fitness landscapes, including whether valleys of low fitness create local fitness optima, acting as barriers to adaptive change. Here we provide evidence of a rugged molecular fitness landscape arising during an evolution experiment in an asexual population of Saccharomyces cerevisiae. We identify the mutations that arose during the evolution using whole-genome sequencing and use competitive fitness assays to describe the mutations individually responsible for adaptation. In addition, we find that a fitness valley between two adaptive mutations in the genes MTH1 and HXT6/HXT7 is caused by reciprocal sign epistasis, where the fitness cost of the double mutant prohibits the two mutations from being selected in the same genetic background. The constraint enforced by reciprocal sign epistasis causes the mutations to remain mutually exclusive during the experiment, even though adaptive mutations in these two genes occur several times in independent lineages during the experiment. Our results show that epistasis plays a key role during adaptation and that inter-genic interactions can act as barriers between adaptive solutions. These results also provide a new interpretation on the classic Dobzhansky-Muller model of reproductive isolation and display some surprising parallels with mutations in genes often associated with tumors.

  2. Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.

    Directory of Open Access Journals (Sweden)

    Daniel J Kvitek

    2011-04-01

    Full Text Available The fitness landscape captures the relationship between genotype and evolutionary fitness and is a pervasive metaphor used to describe the possible evolutionary trajectories of adaptation. However, little is known about the actual shape of fitness landscapes, including whether valleys of low fitness create local fitness optima, acting as barriers to adaptive change. Here we provide evidence of a rugged molecular fitness landscape arising during an evolution experiment in an asexual population of Saccharomyces cerevisiae. We identify the mutations that arose during the evolution using whole-genome sequencing and use competitive fitness assays to describe the mutations individually responsible for adaptation. In addition, we find that a fitness valley between two adaptive mutations in the genes MTH1 and HXT6/HXT7 is caused by reciprocal sign epistasis, where the fitness cost of the double mutant prohibits the two mutations from being selected in the same genetic background. The constraint enforced by reciprocal sign epistasis causes the mutations to remain mutually exclusive during the experiment, even though adaptive mutations in these two genes occur several times in independent lineages during the experiment. Our results show that epistasis plays a key role during adaptation and that inter-genic interactions can act as barriers between adaptive solutions. These results also provide a new interpretation on the classic Dobzhansky-Muller model of reproductive isolation and display some surprising parallels with mutations in genes often associated with tumors.

  3. Bounded fitness landscapes and the evolution of the linguistic diversity

    Science.gov (United States)

    de Oliveira, Viviane M.; Campos, Paulo R. A.; Gomes, M. A. F.; Tsang, I. R.

    2006-08-01

    We have recently introduced a simple spatial computer simulation model to study the evolution of the linguistic diversity. The model considers processes of selective geographic colonization, linguistic anomalous diffusion and mutation. In the approach, we ascribe to each language a fitness function which depends on the number of people that speak that language. Here, we extend the aforementioned model to examine the role of saturation of the fitness on the language dynamics. We found that the dependence of the linguistic diversity on the area after colonization displays a power law regime with a nontrivial exponent in very good agreement with the measured exponent associated with the actual distribution of languages on the Earth.

  4. Bounded fitness landscapes and the evolution of the linguistic diversity

    CERN Document Server

    De Oliveira, V M; Gomes, M A F; Tsang, I R; Campos, Paulo R. A.; Gomes, Marcelo A. F.; Oliveira, Viviane M. de; Tsang, Ing Ren

    2005-01-01

    A simple spatial computer simulation model was recently introduced to study the evolution of the linguistic diversity. The model considers processes of selective geographic colonization, linguistic anomalous diffusion and mutation. In the approach, we ascribe to each language a fitness function which depends on the number of people that speak that language. Here we extend the aforementioned model to examine the role of saturation of the fitness on the language dynamics. We found that the dependence of the linguistic diversity on the area after colonization displays a power law regime with a nontrivial exponent in very good agreement with the measured exponent associated with the actual distribution of languages on the Earth.

  5. Evolution of antibiotic resistance on a mesa-shaped fitness landscape

    Science.gov (United States)

    Hermsen, Rutger; Hwa, Terence

    2010-03-01

    Rapid emergence of drug resistance is one of the biggest problems facing treatment of diseases ranging from bacterial infection to cancer. Recently it was found that, due to a novel growth-mediated positive feedback mechanism, the growth rate of bacteria exposed to sub-lethal antibiotic levels can drop abruptly when the drug level exceeds a sharp threshold (c.f. the preceding talk by Barrett Deris). This threshold level depends on the degree of expression and activity of the protein(s) providing antibiotic resistance. In environments with spatially varying antibiotic concentrations, this dependence gives rise to a mesa-shaped fitness landscape which provides a strong selective pressure for increasing the expression/activity of drug resistance near the cliff in the landscape. We have performed theoretical studies of evolution on such mesa-shaped fitness landscapes. These studies indicate a high rate of adaptation along the fitness cliff, often exceeding that of evolution on smooth fitness landscapes. The results of these studies establish a dynamic mechanism of evolution driven by a fitness cliff and environmental variability, and are conceptually distinct from the classical Darwinian notion of climbing a fitness gradient.

  6. Effect of mutators on adaptability in time-varying fitness landscapes

    Science.gov (United States)

    Gorodetsky, Pavel; Tannenbaum, Emmanuel

    2008-04-01

    This Brief Report studies the quasispecies dynamics of a population capable of genetic repair evolving on a time-dependent fitness landscape. We develop a model that considers an asexual population of single-stranded, conservatively replicating genomes, whose only source of genetic variation is due to copying errors during replication. We consider a time-dependent, single-fitness-peak landscape where the master sequence changes by a single point mutation at every time τ . We are able to analytically solve for the evolutionary dynamics of the population in the point-mutation limit. In particular, our model provides an analytical expression for the fraction of mutators in the dynamic fitness landscape that agrees well with results from stochastic simulations.

  7. Viewing Protein Fitness Landscapes Through a Next-Gen Lens

    Science.gov (United States)

    Boucher, Jeffrey I.; Cote, Pamela; Flynn, Julia; Jiang, Li; Laban, Aneth; Mishra, Parul; Roscoe, Benjamin P.; Bolon, Daniel N. A.

    2014-01-01

    High-throughput sequencing has enabled many powerful approaches in biological research. Here, we review sequencing approaches to measure frequency changes within engineered mutational libraries subject to selection. These analyses can provide direct estimates of biochemical and fitness effects for all individual mutations across entire genes (and likely compact genomes in the near future) in genetically tractable systems such as microbes, viruses, and mammalian cells. The effects of mutations on experimental fitness can be assessed using sequencing to monitor time-dependent changes in mutant frequency during bulk competitions. The impact of mutations on biochemical functions can be determined using reporters or other means of separating variants based on individual activities (e.g., binding affinity for a partner molecule can be interrogated using surface display of libraries of mutant proteins and isolation of bound and unbound populations). The comprehensive investigation of mutant effects on both biochemical function and experimental fitness provide promising new avenues to investigate the connections between biochemistry, cell physiology, and evolution. We summarize recent findings from systematic mutational analyses; describe how they relate to a field rich in both theory and experimentation; and highlight how they may contribute to ongoing and future research into protein structure–function relationships, systems-level descriptions of cell physiology, and population-genetic inferences on the relative contributions of selection and drift. PMID:25316787

  8. Spin models inferred from patient data faithfully describe HIV fitness landscapes and enable rational vaccine design

    CERN Document Server

    Shekhar, Karthik; Ferguson, Andrew L; Barton, John P; Kardar, Mehran; Chakraborty, Arup K

    2013-01-01

    Mutational escape from vaccine induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus' fitness as a function of its proteomic sequence can enable rational design of potent vaccines, as this information can focus vaccine induced immune responses to target mutational vulnerabilities of the virus. Spin models have been proposed as a means to infer intrinsic fitness landscapes of HIV proteins from patient-derived viral protein sequences. These sequences are the product of non-equilibrium viral evolution driven by patient-specific immune responses, and are subject to phylogenetic constraints. How can such sequence data allow inference of intrinsic fitness landscapes? We combined computer simulations and variational theory \\'{a} la Feynman to show that, in most circumstances, spin models inferred from patient-derived viral sequences reflect the correct rank order of the fitness of mutant viral strains. Our f...

  9. Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes

    Science.gov (United States)

    Shekhar, Karthik; Ruberman, Claire F.; Ferguson, Andrew L.; Barton, John P.; Kardar, Mehran; Chakraborty, Arup K.

    2013-12-01

    Mutational escape from vaccine-induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus' fitness as a function of its proteomic sequence can enable rational design of potent vaccines, as this information can focus vaccine-induced immune responses to target mutational vulnerabilities of the virus. Spin models have been proposed as a means to infer intrinsic fitness landscapes of HIV proteins from patient-derived viral protein sequences. These sequences are the product of nonequilibrium viral evolution driven by patient-specific immune responses and are subject to phylogenetic constraints. How can such sequence data allow inference of intrinsic fitness landscapes? We combined computer simulations and variational theory á la Feynman to show that, in most circumstances, spin models inferred from patient-derived viral sequences reflect the correct rank order of the fitness of mutant viral strains. Our findings are relevant for diverse viruses.

  10. Efficient escape from local optima in a highly rugged fitness landscape by evolving RNA virus populations.

    Science.gov (United States)

    Cervera, Héctor; Lalić, Jasna; Elena, Santiago F

    2016-08-17

    Predicting viral evolution has proven to be a particularly difficult task, mainly owing to our incomplete knowledge of some of the fundamental principles that drive it. Recently, valuable information has been provided about mutation and recombination rates, the role of genetic drift and the distribution of mutational, epistatic and pleiotropic fitness effects. However, information about the topography of virus' adaptive landscapes is still scarce, and to our knowledge no data has been reported so far on how its ruggedness may condition virus' evolvability. Here, we show that populations of an RNA virus move efficiently on a rugged landscape and scape from the basin of attraction of a local optimum. We have evolved a set of Tobacco etch virus genotypes located at increasing distances from a local adaptive optimum in a highly rugged fitness landscape, and we observed that few evolved lineages remained trapped in the local optimum, while many others explored distant regions of the landscape. Most of the diversification in fitness among the evolved lineages was explained by adaptation, while historical contingency and chance events contribution was less important. Our results demonstrate that the ruggedness of adaptive landscapes is not an impediment for RNA viruses to efficiently explore remote parts of it. © 2016 The Author(s).

  11. The interpretations and uses of fitness landscapes in the social sciences

    NARCIS (Netherlands)

    L.M. Gerrits (Lasse); P.K. Marks (Peter)

    2014-01-01

    markdownabstract__Abstract__ This working paper precedes our full article entitled “The evolution of Wright’s (1932) adaptive field to contemporary interpretations and uses of fitness landscapes in the social sciences” as published in the journal Biology & Philosophy (http://link.springer.com/artic

  12. Phase diagram for the Eigen quasispecies theory with a truncated fitness landscape

    Science.gov (United States)

    Saakian, David B.; Biebricher, Christof K.; Hu, Chin-Kun

    2009-04-01

    Using methods of statistical physics, we present rigorous theoretical calculations of Eigen’s quasispecies theory with the truncated fitness landscape which dramatically limits the available sequence space of information carriers. As the mutation rate is increased from small values to large values, one can observe three phases: the first (I) selective (also known as ferromagnetic) phase, the second (II) intermediate phase with some residual order, and the third (III) completely randomized (also known as paramagnetic) phase. We calculate the phase diagram for these phases and the concentration of information carriers in the master sequence (also known as peak configuration) x0 and other classes of information carriers. As the phase point moves across the boundary between phase I and phase II, x0 changes continuously; as the phase point moves across the boundary between phase II and phase III, x0 has a large change. Our results are applicable for the general case of a fitness landscape.

  13. Recombination accelerates adaptation on a large-scale empirical fitness landscape in HIV-1.

    Science.gov (United States)

    Moradigaravand, Danesh; Kouyos, Roger; Hinkley, Trevor; Haddad, Mojgan; Petropoulos, Christos J; Engelstädter, Jan; Bonhoeffer, Sebastian

    2014-06-01

    Recombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation on a large-scale empirical fitness landscape in HIV-1 based on in vitro fitness measurements. Our results indicate that recombination substantially increases the rate of adaptation under a wide range of parameter values for population size, mutation rate and recombination rate. The accelerating effect of recombination is stronger for intermediate mutation rates but increases in a monotonic way with the recombination rates and population sizes that we examined. We also found that both fitness effects of individual mutations and epistatic fitness interactions cause recombination to accelerate adaptation. The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I.

  14. Robust Organizational Fitness for Reinventing Strategy in Rapidly Changing Industry Landscapes

    OpenAIRE

    Beer, Michael; Voelpel, Sven C.; Leibold, Marius

    2003-01-01

    In fast-changing industry landscapes, companies are often engaged in both adaptive (reactive) and inventive (proactive, newly-shaping) change processes, and these require different types of organizational fitness capabilities. Our research of more than a decade conducted in a wide range of industries (See "About our Research") reveal that many companies are predominantly focused on past successes and internal difficulties, and do not possess the necessary robust capabilities to also inventive...

  15. Finite population size effects in quasispecies models with single-peak fitness landscape

    Science.gov (United States)

    Saakian, David B.; Deem, Michael W.; Hu, Chin-Kun

    2012-04-01

    We consider finite population size effects for Crow-Kimura and Eigen quasispecies models with single-peak fitness landscape. We formulate accurately the iteration procedure for the finite population models, then derive the Hamilton-Jacobi equation (HJE) to describe the dynamic of the probability distribution. The steady-state solution of HJE gives the variance of the mean fitness. Our results are useful for understanding the population sizes of viruses in which the infinite population models can give reliable results for biological evolution problems.

  16. Genotype to phenotype mapping and the fitness landscape of the E. coli lac promoter.

    Directory of Open Access Journals (Sweden)

    Jakub Otwinowski

    Full Text Available Genotype-to-phenotype maps and the related fitness landscapes that include epistatic interactions are difficult to measure because of their high dimensional structure. Here we construct such a map using the recently collected corpora of high-throughput sequence data from the 75 base pairs long mutagenized E. coli lac promoter region, where each sequence is associated with its phenotype, the induced transcriptional activity measured by a fluorescent reporter. We find that the additive (non-epistatic contributions of individual mutations account for about two-thirds of the explainable phenotype variance, while pairwise epistasis explains about 7% of the variance for the full mutagenized sequence and about 15% for the subsequence associated with protein binding sites. Surprisingly, there is no evidence for third order epistatic contributions, and our inferred fitness landscape is essentially single peaked, with a small amount of antagonistic epistasis. There is a significant selective pressure on the wild type, which we deduce to be multi-objective optimal for gene expression in environments with different nutrient sources. We identify transcription factor (CRP and RNA polymerase binding sites in the promotor region and their interactions without difficult optimization steps. In particular, we observe evidence for previously unexplored genetic regulatory mechanisms, possibly kinetic in nature. We conclude with a cautionary note that inferred properties of fitness landscapes may be severely influenced by biases in the sequence data.

  17. Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes

    Science.gov (United States)

    Shekhar, Karthik; Ruberman, Claire F.; Ferguson, Andrew L.; Barton, John P.; Kardar, Mehran; Chakraborty, Arup K.

    2017-01-01

    Mutational escape from vaccine-induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus’ fitness as a function of its proteomic sequence can enable rational design of potent vaccines, as this information can focus vaccine-induced immune responses to target mutational vulnerabilities of the virus. Spin models have been proposed as a means to infer intrinsic fitness landscapes of HIV proteins from patient-derived viral protein sequences. These sequences are the product of nonequilibrium viral evolution driven by patient-specific immune responses and are subject to phylogenetic constraints. How can such sequence data allow inference of intrinsic fitness landscapes? We combined computer simulations and variational theory á la Feynman to show that, in most circumstances, spin models inferred from patient-derived viral sequences reflect the correct rank order of the fitness of mutant viral strains. Our findings are relevant for diverse viruses. PMID:24483484

  18. Natural resource landscapes of a marine bacterium reveal distinct fitness-determining genes across the genome.

    Science.gov (United States)

    Takemura, Alison F; Corzett, Christopher H; Hussain, Fatima; Arevalo, Philip; Datta, Manoshi; Yu, Xiaoqian; Le Roux, Frederique; Polz, Martin F

    2017-06-01

    Heterotrophic bacteria exploit diverse microhabitats in the ocean, from particles to transient gradients. Yet the degree to which genes and pathways can contribute to an organism's fitness on such complex and variable natural resource landscapes remains poorly understood. Here, we determine the gene-by-gene fitness of a generalist saprophytic marine bacterium (Vibrio sp. F13 9CS106) on complex resources derived from its natural habitats - copepods (Apocyclops royi) and brown algae (Fucus vesiculosus) - and as reference substrates, glucose and the polysaccharide alginate, derived from brown algal cell walls. We find that resource complexity strongly buffers fitness costs of mutations, and that anabolic rather than catabolic pathways are more stringently required, likely due to functional redundancy in the latter. Moreover, while carbohydrate-rich algae requires several synthesis pathways, protein-rich Apocyclops does not, suggesting this ancestral habitat for Vibrios is a replete medium with metabolically redundant substrates. We also identify a candidate fitness trade-off for algal colonization: deletion of mshA increases mutant fitness. Our results demonstrate that gene fitness depends on habitat composition, and suggest that this generalist uses distinct resources in different natural habitats. The results further indicate that substrate replete conditions may lead to relatively relaxed selection on catabolic genes. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

  19. A phase transition induces chaos in a predator-prey ecosystem with a dynamic fitness landscape.

    Directory of Open Access Journals (Sweden)

    William Gilpin

    2017-07-01

    Full Text Available In many ecosystems, natural selection can occur quickly enough to influence the population dynamics and thus future selection. This suggests the importance of extending classical population dynamics models to include such eco-evolutionary processes. Here, we describe a predator-prey model in which the prey population growth depends on a prey density-dependent fitness landscape. We show that this two-species ecosystem is capable of exhibiting chaos even in the absence of external environmental variation or noise, and that the onset of chaotic dynamics is the result of the fitness landscape reversibly alternating between epochs of stabilizing and disruptive selection. We draw an analogy between the fitness function and the free energy in statistical mechanics, allowing us to use the physical theory of first-order phase transitions to understand the onset of rapid cycling in the chaotic predator-prey dynamics. We use quantitative techniques to study the relevance of our model to observational studies of complex ecosystems, finding that the evolution-driven chaotic dynamics confer community stability at the "edge of chaos" while creating a wide distribution of opportunities for speciation during epochs of disruptive selection-a potential observable signature of chaotic eco-evolutionary dynamics in experimental studies.

  20. Fitness landscapes in natural rocks system evolution: A conceptual DFT treatment

    Indian Academy of Sciences (India)

    Soma Duley; Jean-Louis Vigneresse; Pratim Kumar Chattaraj

    2012-01-01

    The chemical reactivity descriptors, such as electronegativity, hardness and electrophilicity of major oxides computed from density functional theory are reported in this paper. These parameters are plotted within a fitness landscape diagram, showing that the principles of minimum electrophilicity (MEP) and maximum hardness (MHP) act as guides towards the region of higher stability. The diagrams indicate the trends and the parameters that control the evolution of natural rocks. Application of the principle S-bearing copper compounds shows the possible and preferred combinations of elements, that give rise to compounds observed during ore formation.

  1. Error catastrophe and phase transition in the empirical fitness landscape of HIV

    Science.gov (United States)

    Hart, Gregory R.; Ferguson, Andrew L.

    2015-03-01

    We have translated clinical sequence databases of the p6 HIV protein into an empirical fitness landscape quantifying viral replicative capacity as a function of the amino acid sequence. We show that the viral population resides close to a phase transition in sequence space corresponding to an "error catastrophe" beyond which there is lethal accumulation of mutations. Our model predicts that the phase transition may be induced by drug therapies that elevate the mutation rate, or by forcing mutations at particular amino acids. Applying immune pressure to any combination of killer T-cell targets cannot induce the transition, providing a rationale for why the viral protein can exist close to the error catastrophe without sustaining fatal fitness penalties due to adaptive immunity.

  2. Quantifying the role of population subdivision in evolution on rugged fitness landscapes.

    Science.gov (United States)

    Bitbol, Anne-Florence; Schwab, David J

    2014-08-01

    Natural selection drives populations towards higher fitness, but crossing fitness valleys or plateaus may facilitate progress up a rugged fitness landscape involving epistasis. We investigate quantitatively the effect of subdividing an asexual population on the time it takes to cross a fitness valley or plateau. We focus on a generic and minimal model that includes only population subdivision into equivalent demes connected by global migration, and does not require significant size changes of the demes, environmental heterogeneity or specific geographic structure. We determine the optimal speedup of valley or plateau crossing that can be gained by subdivision, if the process is driven by the deme that crosses fastest. We show that isolated demes have to be in the sequential fixation regime for subdivision to significantly accelerate crossing. Using Markov chain theory, we obtain analytical expressions for the conditions under which optimal speedup is achieved: valley or plateau crossing by the subdivided population is then as fast as that of its fastest deme. We verify our analytical predictions through stochastic simulations. We demonstrate that subdivision can substantially accelerate the crossing of fitness valleys and plateaus in a wide range of parameters extending beyond the optimal window. We study the effect of varying the degree of subdivision of a population, and investigate the trade-off between the magnitude of the optimal speedup and the width of the parameter range over which it occurs. Our results, obtained for fitness valleys and plateaus, also hold for weakly beneficial intermediate mutations. Finally, we extend our work to the case of a population connected by migration to one or several smaller islands. Our results demonstrate that subdivision with migration alone can significantly accelerate the crossing of fitness valleys and plateaus, and shed light onto the quantitative conditions necessary for this to occur.

  3. Imperfect DNA lesion repair in the semiconservative quasispecies model: Derivation of the Hamming class equations and solution of the single-fitness peak landscape

    Science.gov (United States)

    Tannenbaum, Emmanuel; Sherley, James L.; Shakhnovich, Eugene I.

    2004-12-01

    This paper develops a Hamming class formalism for the semiconservative quasispecies equations with imperfect lesion repair, first presented and analytically solved in Y. Brumer and E.I. Shakhnovich (q-bio.GN/0403018, 2004). Starting from the quasispecies dynamics over the space of genomes, we derive an equivalent dynamics over the space of ordered sequence pairs. From this set of equations, we are able to derive the infinite sequence length form of the dynamics for a class of fitness landscapes defined by a master genome. We use these equations to solve for a generalized single-fitness-peak landscape, where the master genome can sustain a maximum number of lesions and remain viable. We determine the mean equilibrium fitness and error threshold for this class of landscapes, and show that when lesion repair is imperfect, semiconservative replication displays characteristics from both conservative replication and semiconservative replication with perfect lesion repair. The work presented here provides a formulation of the model which greatly facilitates the analysis of a relatively broad class of fitness landscapes, and thus serves as a convenient springboard into biological applications of imperfect lesion repair.

  4. Calculation of the Relative Density and the Crossing Time Through the Fitness Barrier in AN Asymmetric Sharply-Peaked Landscape

    Science.gov (United States)

    Lee, Kwang Sung; Gill, Wonpyong

    We have calculated the relative density and crossing time through the fitness barrier by switching on an asymmetric sharply-peaked landscape, from the initial state which is the quasispecies in a sharply-peaked landscape. It is found that the increment of the relative density with the reversal sequence is a linearly increasing function of time unless a new stationary state in an asymmetric sharply-peaked landscape is reached. It is also found that the relative density with the reversal sequence at the new stationary state X*L is in inverse proportion to the asymmetric parameter when the asymmetric parameter is greater than the saturation asymmetric parameter. We have derived the approximate formulae for the relaxation time, the saturation asymmetric parameter, and the relative density with the reversal sequence X*L, which nicely fit computer simulation results. It is found that the crossing time diverges at the critical fitness parameter in the asymmetric sharply-peaked landscape, in contrast with the symmetric sharply-peaked landscape where the crossing time scales as a power law in the fitness parameter. It is also found that the critical fitness parameter decreases as the asymmetric parameter and sequence length increase.

  5. Technology Trends Analysis Using Patent Landscaping

    Directory of Open Access Journals (Sweden)

    Sergey Vsevolodovich Kortov

    2017-09-01

    Full Text Available The article is devoted to the analysis and the choice of the priorities in technology development and, particularly, to the use of patent landscaping as a tool for the study of technology trends. Currently, patent activity indicators are often used for technology foresight and for competitive intelligence as well. Nevertheless, causal relationship between these indicators, on the one hand, and strategic and tactical decisions in the sphere of technological development on meso- and microeconomic level, on the other hand, are not adequately investigated to solve practical tasks. The goal of the work is to systemize the challenges of technology trends analysis, which could be effectively solved on the base of patent landscape analysis. The article analyses the patent landscaping methodology and tools, as well as their use for evaluating the current competitive environment and technology foresight. The authors formulated the generalized classification for the criteria of promising technologies for a selected region. To assess the compliance of a technology with these criteria, we propose a system of corresponding indicators of patenting activity. Using the proposed methodology, we have analysed the patent landscape to select promising technologies for the Sverdlovsk region. The research confirmed the hypothesis of the patent landscapes performance in evaluating such technology indicators as stages of the life cycle stage, universality (applicability in different industries, pace of worldwide development, innovations and science availability in the region and potential possibilities for scientific collaboration with international research institutions and universities. The results of the research may be useful to the wide audience, including representatives small and medium enterprises, large companies and regional authorities for the tasks concerned with the technology trends analysis and technology strategy design

  6. Evolutionary dynamics of the most populated genotype on rugged fitness landscapes

    Science.gov (United States)

    Jain, Kavita

    2007-09-01

    We consider an asexual population evolving on rugged fitness landscapes which are defined on the multidimensional genotypic space and have many local optima. We track the most populated genotype as it changes when the population jumps from a fitness peak to a better one during the process of adaptation. This is done using the dynamics of the shell model which is a simplified version of the quasispecies model for infinite populations and standard Wright-Fisher dynamics for large finite populations. We show that the population fraction of a genotype obtained within the quasispecies model and the shell model match for fit genotypes and at short times, but the dynamics of the two models are identical for questions related to the most populated genotype. We calculate exactly several properties of the jumps in infinite populations, some of which were obtained numerically in previous works. We also present our preliminary simulation results for finite populations. In particular, we measure the jump distribution in time and find that it decays as t-2 as in the quasispecies problem.

  7. Linguistic Landscape and Space: A Multimodal Analysis of Linguistic landscape in Robot Open Space

    Directory of Open Access Journals (Sweden)

    Song Chen

    2016-11-01

    Full Text Available The paper examines the linguistic landscape in an indoor public place, Robot Open Space in Zhongguancun Dream Laboratory, which is a building housing a handful of innovative entrepreneurial enterprises. The subject of analysis in this present paper is the impact of different spaces on the features of linguistic landscape. Each of the three major sub-spaces in the company Robot Open Space has different functions and the linguistic landscape with its different features varies accordingly. This present study has the following contributions. First, the shift of analytical attention from the outdoor linguistic landscape to the indoor linguistic landscape provides a new angle for LL analysis and further expands the scenery of linguistic landscape. Then, the newly establish analytical framework, the “multimodal model for linguistic landscape analysis” enrich the current theoretical models that is quite rare. Last, the qualitative analysis of the linguistic landscapes in different spaces shed light on the correlation between space and linguistic landscape, indicating that space is an integral factor to be considered when it comes to LL analysis.Keywords: linguistic landscape; multimodal model; qualitative analysis; space

  8. Biomedical model fitting and error analysis.

    Science.gov (United States)

    Costa, Kevin D; Kleinstein, Steven H; Hershberg, Uri

    2011-09-20

    This Teaching Resource introduces students to curve fitting and error analysis; it is the second of two lectures on developing mathematical models of biomedical systems. The first focused on identifying, extracting, and converting required constants--such as kinetic rate constants--from experimental literature. To understand how such constants are determined from experimental data, this lecture introduces the principles and practice of fitting a mathematical model to a series of measurements. We emphasize using nonlinear models for fitting nonlinear data, avoiding problems associated with linearization schemes that can distort and misrepresent the data. To help ensure proper interpretation of model parameters estimated by inverse modeling, we describe a rigorous six-step process: (i) selecting an appropriate mathematical model; (ii) defining a "figure-of-merit" function that quantifies the error between the model and data; (iii) adjusting model parameters to get a "best fit" to the data; (iv) examining the "goodness of fit" to the data; (v) determining whether a much better fit is possible; and (vi) evaluating the accuracy of the best-fit parameter values. Implementation of the computational methods is based on MATLAB, with example programs provided that can be modified for particular applications. The problem set allows students to use these programs to develop practical experience with the inverse-modeling process in the context of determining the rates of cell proliferation and death for B lymphocytes using data from BrdU-labeling experiments.

  9. Statistical properties and error threshold of quasispecies on single-peak Gaussian-distributed fitness landscapes.

    Science.gov (United States)

    Li, Duo-Fang; Cao, Tian-Guang; Geng, Jin-Peng; Gu, Jian-Zhong; An, Hai-Long; Zhan, Yong

    2015-09-07

    The stochastic Eigen model proposed by Feng et al. (2007) (Journal of Theoretical Biology, 246, 28) showed that error threshold is no longer a phase transition point but a crossover region whose width depends on the strength of the random fluctuation in an environment. The underlying cause of this phenomenon has not yet been well examined. In this article, we adopt a single peak Gaussian distributed fitness landscape instead of a constant one to investigate and analyze the change of the error threshold and the statistical property of the quasi-species population. We find a roughly linear relation between the width of the error threshold and the fitness fluctuation strength. For a given quasi-species, the fluctuation of the relative concentration has a minimum with a normal distribution of the relative concentration at the maximum of the averaged relative concentration, it has however a largest value with a bimodal distribution of the relative concentration near the error threshold. The above results deepen our understanding of the quasispecies and error threshold and are heuristic for exploring practicable antiviral strategies.

  10. Visual unit analysis: a descriptive approach to landscape assessment

    Science.gov (United States)

    R. J. Tetlow; S. R. J. Sheppard

    1979-01-01

    Analysis of the visible attributes of landscapes is an important component of the planning process. When landscapes are at regional scale, economical and effective methodologies are critical. The Visual Unit concept appears to offer a logical and useful framework for description and evaluation. The concept subdivides landscape into coherent, spatially-defined units....

  11. Using Landscape Metrics Analysis and Analytic Hierarchy Process to Assess Water Harvesting Potential Sites in Jordan

    Directory of Open Access Journals (Sweden)

    Abeer Albalawneh

    2015-09-01

    Full Text Available Jordan is characterized as a “water scarce” country. Therefore, conserving ecosystem services such as water regulation and soil retention is challenging. In Jordan, rainwater harvesting has been adapted to meet those challenges. However, the spatial composition and configuration features of a target landscape are rarely considered when selecting a rainwater-harvesting site. This study aimed to introduce landscape spatial features into the schemes for selecting a proper water-harvesting site. Landscape metrics analysis was used to quantify 10 metrics for three potential landscapes (i.e., Watershed 104 (WS 104, Watershed 59 (WS 59, and Watershed 108 (WS 108 located in the Jordanian Badia region. Results of the metrics analysis showed that the three non–vegetative land cover types in the three landscapes were highly suitable for serving as rainwater harvesting sites. Furthermore, Analytic Hierarchy Process (AHP was used to prioritize the fitness of the three target sites by comparing their landscape metrics. Results of AHP indicate that the non-vegetative land cover in the WS 104 landscape was the most suitable site for rainwater harvesting intervention, based on its dominance, connectivity, shape, and low degree of fragmentation. Our study advances the water harvesting network design by considering its landscape spatial pattern.

  12. High-throughput identification of protein mutant stability computed from a double mutant fitness landscape.

    Science.gov (United States)

    Wu, Nicholas C; Olson, C Anders; Sun, Ren

    2016-02-01

    The effect of a mutation on protein stability is traditionally measured by genetic construction, expression, purification, and physical analysis using low-throughput methods. This process is tedious and limits the number of mutants able to be examined in a single study. In contrast, functional fitness effects can be measured in a high-throughput manner by various deep mutational scanning tools. Using protein GB 1, we have recently demonstrated the feasibility of estimating the mutational stability effect ( ΔΔG) of single-substitution based on the functional fitness profile of all double-substitutions. The principle is to identify genetic backgrounds that have an exhausted stability margin. The functional effect of an additional substitution on these genetic backgrounds can then be used to compute the mutational ΔΔG based on the biophysical relationship between functional fitness and thermodynamic stability. However, to identify such genetic backgrounds, the approach described in our previous study required a benchmark dataset, which is a set of known mutational ΔΔG. In this study, a benchmark-independent approach is developed. The genetic backgrounds of interest are identified using k-means clustering with the integration of structural information. We further demonstrated that a reasonable approximation of ΔΔG can also be obtained without taking structural information into account. In summary, this study describes a novel method for computing ΔΔG from double-substitution functional fitness profiles alone, without relying on any known mutational ΔΔG as a benchmark.

  13. Robust fitting for pulsar timing analysis

    Science.gov (United States)

    Wang, Yidi; Keith, Michael J.; Stappers, Benjamin; Zheng, Wei

    2017-07-01

    We introduce a robust fitting method into pulsar timing analysis to cope with the non-Gaussian noise. The general maximum likelihood estimator (M-estimator) can resist the impact of non-Gaussian noise by employing convex and bounded loss functions. Three loss functions, including the Huber function, the Bisquare function and the Welsch function, are investigated. The Shapiro-Wilk test is employed to test whether the uncertainty in the observed times of arrival is drawn from a non-Gaussian distribution. Two simulations, where the non-Gaussian distribution is modelled as contaminated Gaussian distributions, are performed. It is found that M-estimators are unbiased and could achieve a root-mean-square error smaller than that obtained by the least square (LS) at the cost of a slightly higher computation complexity in a non-Gaussian environment. M-estimators are also applied to the real timing data of PSR J1713+0747. The results have shown that the fitting results of M-estimators are more accurate than those of LS and are closer to the result of very long baseline interferometry.

  14. Uncertainties in landscape analysis and ecosystem service assessment.

    Science.gov (United States)

    Hou, Y; Burkhard, B; Müller, F

    2013-09-01

    Landscape analysis and ecosystem service assessment have drawn increasing concern from research and application at the landscape scale. Thanks to the continuously emerging assessments as well as studies aiming at evaluation method improvement, policy makers and landscape managers have an increasing interest in integrating ecosystem services into their decisions. However, the plausible assessments carry numerous sources of uncertainties, which regrettably tend to be ignored or disregarded by the actors or researchers. In order to cope with uncertainties and make them more transparent for landscape managers, we demonstrate them by reviewing literature, describing an example and proposing approaches for uncertainty analysis. Additionally, we conclude with potential actions to reduce the insecurities accompanying landscape analysis and ecosystem service assessments. As for landscape analysis, the fundamental uncertainty origins are landscape complexity and methodological uncertainties. Concerning the uncertainty sources of ecosystem service assessments, the complexity of the natural system, respondents' preferences and technical problems play essential roles. By analyzing the assessment process, we find that initial data uncertainty pervades the whole assessment and argue that the limited knowledge about the complexity of ecosystems is the focal origin of uncertainties. For analyzing uncertainties in assessments, we propose systems analysis, scenario simulation and the comparison method as promising strategies. To reduce uncertainties, we assume that actions should integrate continuous learning, expanding respondent numbers and sources, considering representativeness, improving and standardizing assessment methods and optimizing spatial and geobiophysical data. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Quantitative analysis of forest island pattern in selected Ohio landscapes

    Energy Technology Data Exchange (ETDEWEB)

    Bowen, G.W.; Burgess, R.L.

    1981-07-01

    The purpose of this study was to quantitatively describe the various aspects of regional distribution patterns of forest islands and relate those patterns to other landscape features. Several maps showing the forest cover of various counties in Ohio were selected as representative examples of forest patterns to be quantified. Ten thousand hectare study areas (landscapes) were delineated on each map. A total of 15 landscapes representing a wide variety of forest island patterns was chosen. Data were converted into a series of continuous variables which contained information pertinent to the sizes, shape, numbers, and spacing of woodlots within a landscape. The continuous variables were used in a factor analysis to describe the variation among landscapes in terms of forest island pattern. The results showed that forest island patterns are related to topography and other environmental features correlated with topography.

  16. The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing.

    Directory of Open Access Journals (Sweden)

    Jaclyn K Mann

    2014-08-01

    Full Text Available Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design. To address this challenge, our group has developed a computational model, rooted in physics, that aims to predict the fitness landscape of HIV-1 proteins in order to design vaccine immunogens that lead to impaired viral fitness, thus blocking viable escape routes. Here, we advance the computational models to address previous limitations, and directly test model predictions against in vitro fitness measurements of HIV-1 strains containing multiple Gag mutations. We incorporated regularization into the model fitting procedure to address finite sampling. Further, we developed a model that accounts for the specific identity of mutant amino acids (Potts model, generalizing our previous approach (Ising model that is unable to distinguish between different mutant amino acids. Gag mutation combinations (17 pairs, 1 triple and 25 single mutations within these predicted to be either harmful to HIV-1 viability or fitness-neutral were introduced into HIV-1 NL4-3 by site-directed mutagenesis and replication capacities of these mutants were assayed in vitro. The predicted and measured fitness of the corresponding mutants for the original Ising model (r = -0.74, p = 3.6×10-6 are strongly correlated, and this was further strengthened in the regularized Ising model (r = -0.83, p = 3.7×10-12. Performance of the Potts model (r = -0.73, p = 9.7×10-9 was similar to that of the Ising model, indicating that the binary approximation is sufficient for capturing fitness effects of common mutants at sites of low amino acid diversity. However, we show that the Potts model is expected to improve predictive power for more variable proteins. Overall, our results support the ability of the computational models to robustly predict the relative fitness of mutant viral strains, and indicate the potential value of this approach for understanding viral immune evasion

  17. Sources to the landscape - detailed spatiotemporal analysis of 200 years Danish landscape dynamics using unexploited historical maps and aerial photos

    DEFF Research Database (Denmark)

    Svenningsen, Stig Roar; Christensen, Andreas Aagaard; Dupont, Henrik

    Historical cartographic material in the form of maps and aerial imagery remains one of the main data sources available to landscape scientists studying changes in land use and land cover. The use and analysis of such sources is widespread, and most contemporary scholars in the landscape sciences...... use historical maps and imagery to relate their findings to landscape history. Especially the recent transition from a landscape dominated by feudal societal structures to today’s urbanized landscapes with intensive agriculture, has been intensively studied. This approach in some cases suffers from...... or to the commercial photo series from the last 20 years. This poster outlines a new research project focusing on the potential of unexploited cartographic sources for detailed analysis of the dynamic of the Danish landscape between 1800 – 2000. The project draws on cartographic sources available in Danish archives...

  18. Sources to the landscape - detailed spatiotemporal analysis of 200 years Danish landscape dynamics using unexploited historical maps and aerial photos

    DEFF Research Database (Denmark)

    Svenningsen, Stig Roar; Christensen, Andreas Aagaard; Dupont, Henrik

    Historical cartographic material in the form of maps and aerial imagery remains one of the main data sources available to landscape scientists studying changes in land use and land cover. The use and analysis of such sources is widespread, and most contemporary scholars in the landscape sciences...... use historical maps and imagery to relate their findings to landscape history. Especially the recent transition from a landscape dominated by feudal societal structures to today’s urbanized landscapes with intensive agriculture, has been intensively studied. This approach in some cases suffers from...... or to the commercial photo series from the last 20 years. This poster outlines a new research project focusing on the potential of unexploited cartographic sources for detailed analysis of the dynamic of the Danish landscape between 1800 – 2000. The project draws on cartographic sources available in Danish archives...

  19. Random versus Deterministic Descent in RNA Energy Landscape Analysis

    Directory of Open Access Journals (Sweden)

    Luke Day

    2016-01-01

    Full Text Available Identifying sets of metastable conformations is a major research topic in RNA energy landscape analysis, and recently several methods have been proposed for finding local minima in landscapes spawned by RNA secondary structures. An important and time-critical component of such methods is steepest, or gradient, descent in attraction basins of local minima. We analyse the speed-up achievable by randomised descent in attraction basins in the context of large sample sets where the size has an order of magnitude in the region of ~106. While the gain for each individual sample might be marginal, the overall run-time improvement can be significant. Moreover, for the two nongradient methods we analysed for partial energy landscapes induced by ten different RNA sequences, we obtained that the number of observed local minima is on average larger by 7.3% and 3.5%, respectively. The run-time improvement is approximately 16.6% and 6.8% on average over the ten partial energy landscapes. For the large sample size we selected for descent procedures, the coverage of local minima is very high up to energy values of the region where the samples were randomly selected from the partial energy landscapes; that is, the difference to the total set of local minima is mainly due to the upper area of the energy landscapes.

  20. Process-Driven Ecological Modeling for Landscape Change Analysis

    Science.gov (United States)

    Altman, S.; Reif, M. K.; Swannack, T. M.

    2013-12-01

    Landscape pattern is an important driver in ecosystem dynamics and can control system-level functions such as nutrient cycling, connectivity, biodiversity and carbon sequestration. However, the links between process, pattern and function remain ambiguous. Understanding the quantitative relationship between ecological processes and landscape pattern across temporal and spatial scales is vital for successful management and implementation of ecosystem-level projects. We used remote sensing imagery to develop critical landscape metrics to understand the factors influencing landscape change. Our study area, a coastal area in southwest Florida, is highly dynamic with critically eroding beaches and a range of natural and developed land cover types. Hurricanes in 2004 and 2005 caused a breach along the coast of North Captiva Island that filled in by 2010. We used a time series of light detection and ranging (lidar) elevation data and hyperspectral imagery from 2006 and 2010 to determine land cover changes. Landscape level metrics used included: Largest Patch Index, Class Area, Area-weighted mean area, Clumpiness, Area-weighted Contiguity Index, Number of Patches, Percent of landcover, Area-weighted Shape. Our results showed 1) 27% increase in sand/soil class as the channel repaired itself and shoreline was reestablished, 2) 40% decrease in the mudflat class area due to conversion to sand/soil and water, 3) 30% increase in non-wetland vegetation class as a result of new vegetation around the repaired channel, and 4) the water class only slightly increased though there was a marked increase in the patch size area. Thus, the smaller channels disappeared with the infilling of the channel, leaving much larger, less complex patches behind the breach. Our analysis demonstrated that quantification of landscape pattern is critical to linking patterns to ecological processes and understanding how both affect landscape change. Our proof of concept indicated that ecological processes

  1. Multitemporal spatial pattern analysis of Tulum's tropical coastal landscape

    Science.gov (United States)

    Ramírez-Forero, Sandra Carolina; López-Caloca, Alejandra; Silván-Cárdenas, José Luis

    2011-11-01

    The tropical coastal landscape of Tulum in Quintana Roo, Mexico has a high ecological, economical, social and cultural value, it provides environmental and tourism services at global, national, regional and local levels. The landscape of the area is heterogeneous and presents random fragmentation patterns. In recent years, tourist services of the region has been increased promoting an accelerate expansion of hotels, transportation and recreation infrastructure altering the complex landscape. It is important to understand the environmental dynamics through temporal changes on the spatial patterns and to propose a better management of this ecological area to the authorities. This paper addresses a multi-temporal analysis of land cover changes from 1993 to 2000 in Tulum using Thematic Mapper data acquired by Landsat-5. Two independent methodologies were applied for the analysis of changes in the landscape and for the definition of fragmentation patterns. First, an Iteratively Multivariate Alteration Detection (IR-MAD) algorithm was used to detect and localize land cover change/no-change areas. Second, the post-classification change detection evaluated using the Support Vector Machine (SVM) algorithm. Landscape metrics were calculated from the results of IR-MAD and SVM. The analysis of the metrics indicated, among other things, a higher fragmentation pattern along roadways.

  2. Landscape analysis: Theoretical considerations and practical needs

    Science.gov (United States)

    Godfrey, A.E.; Cleaves, E.T.

    1991-01-01

    Numerous systems of land classification have been proposed. Most have led directly to or have been driven by an author's philosophy of earth-forming processes. However, the practical need of classifying land for planning and management purposes requires that a system lead to predictions of the results of management activities. We propose a landscape classification system composed of 11 units, from realm (a continental mass) to feature (a splash impression). The classification concerns physical aspects rather than economic or social factors; and aims to merge land inventory with dynamic processes. Landscape units are organized using a hierarchical system so that information may be assembled and communicated at different levels of scale and abstraction. Our classification uses a geomorphic systems approach that emphasizes the geologic-geomorphic attributes of the units. Realm, major division, province, and section are formulated by subdividing large units into smaller ones. For the larger units we have followed Fenneman's delineations, which are well established in the North American literature. Areas and districts are aggregated into regions and regions into sections. Units smaller than areas have, in practice, been subdivided into zones and smaller units if required. We developed the theoretical framework embodied in this classification from practical applications aimed at land use planning and land management in Maryland (eastern Piedmont Province near Baltimore) and Utah (eastern Uinta Mountains). ?? 1991 Springer-Verlag New York Inc.

  3. Topological microstructure analysis using persistence landscapes

    Science.gov (United States)

    Dłotko, Paweł; Wanner, Thomas

    2016-11-01

    Phase separation mechanisms can produce a variety of complicated and intricate microstructures, which often can be difficult to characterize in a quantitative way. In recent years, a number of novel topological metrics for microstructures have been proposed, which measure essential connectivity information and are based on techniques from algebraic topology. Such metrics are inherently computable using computational homology, provided the microstructures are discretized using a thresholding process. However, while in many cases the thresholding is straightforward, noise and measurement errors can lead to misleading metric values. In such situations, persistence landscapes have been proposed as a natural topology metric. Common to all of these approaches is the enormous data reduction, which passes from complicated patterns to discrete information. It is therefore natural to wonder what type of information is actually retained by the topology. In the present paper, we demonstrate that averaged persistence landscapes can be used to recover central system information in the Cahn-Hilliard theory of phase separation. More precisely, we show that topological information of evolving microstructures alone suffices to accurately detect both concentration information and the actual decomposition stage of a data snapshot. Considering that persistent homology only measures discrete connectivity information, regardless of the size of the topological features, these results indicate that the system parameters in a phase separation process affect the topology considerably more than anticipated. We believe that the methods discussed in this paper could provide a valuable tool for relating experimental data to model simulations.

  4. Fitting in a complex chi^2 landscape using an optimized hypersurface sampling

    CERN Document Server

    Pardo, L C; Busch, S; Moulin, J -F; Tamarit, J Ll

    2011-01-01

    Fitting a data set with a parametrized model can be seen geometrically as finding the global minimum of the chi^2 hypersurface, depending on a set of parameters {P_i}. This is usually done using the Levenberg-Marquardt algorithm. The main drawback of this algorithm is that despite of its fast convergence, it can get stuck if the parameters are not initialized close to the final solution. We propose a modification of the Metropolis algorithm introducing a parameter step tuning that optimizes the sampling of parameter space. The ability of the parameter tuning algorithm together with simulated annealing to find the global chi^2 hypersurface minimum, jumping across chi^2{P_i} barriers when necessary, is demonstrated with synthetic functions and with real data.

  5. Spatial Characterization of Landscapes through Multifractal Analysis of DEM

    Directory of Open Access Journals (Sweden)

    P. L. Aguado

    2014-01-01

    Full Text Available Landscape evolution is driven by abiotic, biotic, and anthropic factors. The interactions among these factors and their influence at different scales create a complex dynamic. Landscapes have been shown to exhibit numerous scaling laws, from Horton’s laws to more sophisticated scaling of heights in topography and river network topology. This scaling and multiscaling analysis has the potential to characterise the landscape in terms of the statistical signature of the measure selected. The study zone is a matrix obtained from a digital elevation model (DEM (map 10 × 10 m, and height 1 m that corresponds to homogeneous region with respect to soil characteristics and climatology known as “Monte El Pardo” although the water level of a reservoir and the topography play a main role on its organization and evolution. We have investigated whether the multifractal analysis of a DEM shows common features that can be used to reveal the underlying patterns and information associated with the landscape of the DEM mapping and studied the influence of the water level of the reservoir on the applied analysis. The results show that the use of the multifractal approach with mean absolute gradient data is a useful tool for analysing the topography represented by the DEM.

  6. On the identification of hysteretic systems. Part I: Fitness landscapes and evolutionary identification

    Science.gov (United States)

    Worden, K.; Manson, G.

    2012-05-01

    Fairly recent work has shown that evolutionary optimisation schemes (genetic algorithms and differential evolution) offer an effective means of identifying nonlinear dynamical systems, even when the parameter estimation problem is complicated by nonlinearity in the parameters and/or the presence of unmeasured states. In particular, an evolutionary approach to the parameter estimation problem for hysteretic systems has shown promise. The current paper considers aspects of the parameter estimation problem for systems of Bouc-Wen type. In the first place, an investigation into the nature of the objective or cost function for the optimisation is made with the aim of better understanding the performance of the identification scheme. The first part of the paper also discusses the issue of setting initial estimates or ranges for the system parameters. The data on which the analysis is based are generated by computer simulation; the specific evolutionary algorithm considered is Differential Evolution (DE). Although the DE algorithm has proved to be very effective in the identification context, a minor disadvantage manifests itself in the need to set algorithm hyperparameters for the optimisation. This observation leads to the second main objective of the current paper which is to present a recently developed variant of the DE algorithm - the Self-Adaptive Differential Evolution (SADE) algorithm - which learns and adapts a subset of its own hyperparameters throughout the optimisation process. The use of the algorithm for the hysteretic system identification problem is illustrated using the simulated data and it is shown that the algorithm can provide several orders-of-magnitude improvement on the minimisation of the problem objective function.

  7. GIS and Landscape Analysis, or the cart before the horse?

    Directory of Open Access Journals (Sweden)

    Caroline Phillips

    2004-11-01

    Full Text Available Spatial analysis has traditionally considered settlements in relation to each other and aspects of topography. Criticisms of environmental determinism, and identification of problems with site data and analytical models, have followed. Transferring spatial analysis to a GIS platform has not resolved these concerns. This article highlights the fact that there are cultural assumptions within spatial analyses, through examining the land-use systems practised by New Zealand Māori, and argues that models based on modern European land use are not necessarily appropriate for other times and cultures. This test case also supports the contextual archaeology definition of landscape as a dynamic inclusive system between people and land. It is concluded that the resolution of such problems, especially when analysing societies with a recent ethnography or history, requires a landscape approach together with multi-disciplinary data and the further development of dynamic modelling and simulation through GIS.

  8. The Intellectual Landscape of Critical Policy Analysis

    Science.gov (United States)

    Diem, Sarah; Young, Michelle D.; Welton, Anjalé D.; Mansfield, Katherine Cumings; Lee, Pei-Ling

    2014-01-01

    What counts as critical policy analysis in education? Over the past 30 years, a tightening of national educational policies can be seen in the USA and across the globe. Over this same period of time, a growing number of educational policy scholars, dissatisfied with traditional frameworks, have used critical frameworks in their analyses. Their…

  9. Inferring Microbial Fitness Landscapes

    Science.gov (United States)

    2016-02-25

    experiments on evolving microbial populations. Although these experiments have produced examples of remarkable phenomena – e.g. the emergence of mutator...what specific mutations, avian influenza viruses will adapt to novel human hosts; or how readily infectious bacteria will escape antibiotics or the...infer from data the determinants of microbial evolution with sufficient resolution that we can quantify 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND

  10. Cardiorespiratory fitness and laboratory stress: a meta-regression analysis.

    Science.gov (United States)

    Jackson, Erica M; Dishman, Rod K

    2006-01-01

    We performed a meta-regression analysis of 73 studies that examined whether cardiorespiratory fitness mitigates cardiovascular responses during and after acute laboratory stress in humans. The cumulative evidence indicates that fitness is related to slightly greater reactivity, but better recovery. However, effects varied according to several study features and were smallest in the better controlled studies. Fitness did not mitigate integrated stress responses such as heart rate and blood pressure, which were the focus of most of the studies we reviewed. Nonetheless, potentially important areas, particularly hemodynamic and vascular responses, have been understudied. Women, racial/ethnic groups, and cardiovascular patients were underrepresented. Randomized controlled trials, including naturalistic studies of real-life responses, are needed to clarify whether a change in fitness alters putative stress mechanisms linked with cardiovascular health.

  11. Landscape Analysis of Adult Florida Panther Habitat.

    Directory of Open Access Journals (Sweden)

    Robert A Frakes

    Full Text Available Historically occurring throughout the southeastern United States, the Florida panther is now restricted to less than 5% of its historic range in one breeding population located in southern Florida. Using radio-telemetry data from 87 prime-aged (≥3 years old adult panthers (35 males and 52 females during the period 2004 through 2013 (28,720 radio-locations, we analyzed the characteristics of the occupied area and used those attributes in a random forest model to develop a predictive distribution map for resident breeding panthers in southern Florida. Using 10-fold cross validation, the model was 87.5 % accurate in predicting presence or absence of panthers in the 16,678 km2 study area. Analysis of variable importance indicated that the amount of forests and forest edge, hydrology, and human population density were the most important factors determining presence or absence of panthers. Sensitivity analysis showed that the presence of human populations, roads, and agriculture (other than pasture had strong negative effects on the probability of panther presence. Forest cover and forest edge had strong positive effects. The median model-predicted probability of presence for panther home ranges was 0.81 (0.82 for females and 0.74 for males. The model identified 5579 km2 of suitable breeding habitat remaining in southern Florida; 1399 km2 (25% of this habitat is in non-protected private ownership. Because there is less panther habitat remaining than previously thought, we recommend that all remaining breeding habitat in south Florida should be maintained, and the current panther range should be expanded into south-central Florida. This model should be useful for evaluating the impacts of future development projects, in prioritizing areas for panther conservation, and in evaluating the potential impacts of sea-level rise and changes in hydrology.

  12. The Sigiriya Royal Gardens. Analysis of the Landscape Architectonic Composition

    Directory of Open Access Journals (Sweden)

    Jude Nilan Cooray

    2012-11-01

    Full Text Available Besides the efforts that are of descriptive and celebrative nature, studies related to Sri Lanka’s historical built heritage are largely to view material remains in historical, sociological, socio-historical and semiological perspectives. But there is hardly any serious attempt to view such material remains from a technical-analytical approach to understand the compositional aspects of their designs. The 5th century AC royal complex at Sigiriya is no exception in this regard.The enormous wealth of information and the unearthed material remains during more than hundred years of field-based research by several generations of archaeologists at Sigiriya provide ideal opportunity for such an analysis. The present study is, therefore, to fill the gap in research related to Sri Lanka’s historical built heritage in general and to Sigiriya in particular. Therefore the present research attempts to read Sigiriya as a landscape architectonic design to expose its architectonic composition and design instruments.The study which is approached from a technical-analytical point of view follows a methodological framework that is developed at the Landscape Design Department of the Faculty of Architecture at Delft University of Technology. The study reveals that the architectonic design of Sigiriya constitutes multiple design layers and multiple layers of significance with material-spatial-metaphorical-functional coherence, and that it has both general and unique landscape architectonic elements, aspects, characteristics and qualities.The richness of its composition also enables to identify the landscape architectural value of the Sigiriya, which will help re-shape the policies related to conservation and presentation of Sigiriya as a heritage site as well as the protection and management as a green monument. The positive results of the study also underline that the methodology adapted in this research has devised a framework for the study of other examples of

  13. The role of landscape pattern analysis in understanding concepts of land cover change

    Institute of Scientific and Technical Information of China (English)

    JerryAGRIFFITH

    2004-01-01

    Landscape ecology and landscape pattern analysis are important components of national-scale programs to identify trends in land cover change because: 1) Statistics on changes in land cover proportions are not spatial. A change matrix derived from GIS provides useful information, but it does not show the spatial form of change in the landscape. Landscape pattern metrics reveal spatial pattern. 2) A growing body of literature has shown that a change in landscape pattern might indicate important changes in ecological functions: forest connectivity and species movements, number and size of farm patches, effects on water quality. Spatial pattern is important in structuring ecological communities and in maintaining existence of competitors. Spatial pattern may be determined by disturbance and may in turn, determine how disturbances propagate through the system. 3) Sometimes landscape pattern may not significantly change, even though land cover proportions do change. Or, vice-versa, sometimes landscape pattern can significantly change, even though land cover proportions don't significantly change. 4) Landscape pattern is an inherent and important part of describing landscapes: based on the literature, one of the most important descriptive characteristics of a landscape is its texture. The objectives of this paper are to: 1) Explain the importance of the role of landscape ecology and landscape pattern analysis in land cover change studies; 2) Review the literature that specifically incorporates landscape ecology into land cover change studies; and 3) List the theoretical and technical issues involved and suggest solutions for them.

  14. Literature analysis and research progress of the landscape ecology in China in the 1990s

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    This paper makes analysis of published articles and books on landscape ecology in the 1990s through literature collection. The analytical results showed that the study of landscape ecology had made a great advance during the past decade in China. By incomplete survey, Chinese researchers at home and abroad published 619 scientific articles and 13 monographs on landscape ecology in the 1990s, and most of them (more than 90%) were published in Chinese with English abstracts. The published articles on basic theory accounted for 39.6% (245 articles), and those concerning application and methods accounted for 36.8% (228) and 23.6% (146), respectively. According to the objects of research, the published articles on landscape ecology were classified into nine catalogues. The urban landscape ranks first in terms of number of published articles, accounting for 13.4% of the total, followed by regional and river basin landscape, cold and arid landscape, forest landscape, habitat and bio-diversity landscape, agricultural landscape, wetlands, suburban landscape, and vegetation landscape. Based on the analysis, some discussions were made on the existing problems and development trend of landscape ecology study in China

  15. Analysis on the Fusion and Sustainable Developmental of Landscape Sculpture

    Institute of Scientific and Technical Information of China (English)

    LlU Jinmin[1,2; GE Li[1,2

    2015-01-01

    Landscape sculpture, as part of landscape environment, features fusion that is not possessed by other art forms. Therefore, it will lose its existence value and meaning once it is without fusion. Along with the development of the times, landscape sculpture can attain a sustainable development, and this is a highlight in the development of the modem landscape sculpture design.

  16. Funtools: Fits Users Need Tools for Quick, Quantitative Analysis

    Science.gov (United States)

    Mandel, Eric; Brederkamp, Joe (Technical Monitor)

    2001-01-01

    The Funtools project arose out of conversations with astronomers about the decline in their software development efforts over the past decade. A stated reason for this decline is that it takes too much effort to master one of the existing FITS libraries simply in order to write a few analysis programs. This problem is exacerbated by the fact that astronomers typically develop new programs only occasionally, and the long interval between coding efforts often necessitates re-learning the FITS interfaces. We therefore set ourselves the goal of developing a minimal buy-in FITS library for researchers who are occasional (but serious) coders. In this case, "minimal buy-in" meant "easy to learn, easy to use, and easy to re-learn next month". Based on conversations with astronomers interested in writing code, we concluded that this goal could be achieved by emphasizing two essential capabilities. The first was the ability to write FITS programs without knowing much about FITS, i.e., without having to deal with the arcane rules for generating a properly formatted FITS file. The second was to support the use of already-familiar C/Unix facilities, especially C structs and Unix stdio. Taken together, these two capabilities would allow researchers to leverage their existing programming expertise while minimizing the need to learn new and complex coding rules.

  17. Landscape Analysis of Geographical Names in Hubei Province, China

    Directory of Open Access Journals (Sweden)

    Xixi Chen

    2014-12-01

    Full Text Available Hubei Province is the hub of communications in central China, which directly determines its strategic position in the country’s development. Additionally, Hubei Province is well-known for its diverse landforms, including mountains, hills, mounds and plains. This area is called “The Province of Thousand Lakes” due to the abundance of water resources. Geographical names are exclusive names given to physical or anthropogenic geographic entities at specific spatial locations and are important signs by which humans understand natural and human activities. In this study, geographic information systems (GIS technology is adopted to establish a geodatabase of geographical names with particular characteristics in Hubei Province and extract certain geomorphologic and environmental factors. We carry out landscape analysis of mountain-related geographical names and water-related geographical names respectively. In the end, we calculate the information entropy of geographical names of each county to describe the diversity and inhomogeneity of place names in Hubei province. Our study demonstrates that geographical names represent responses to the cultural landscape and physical environment. The geographical names are more interesting in specific landscapes, such as mountains and rivers.

  18. Evaluation of Peak-Fitting Software for Gamma Spectrum Analysis

    CERN Document Server

    Zahn, Guilherme S; Moralles, Maurício

    2015-01-01

    In all applications of gamma-ray spectroscopy, one of the most important and delicate parts of the data analysis is the fitting of the gamma-ray spectra, where information as the number of counts, the position of the centroid and the width, for instance, are associated with each peak of each spectrum. There's a huge choice of computer programs that perform this type of analysis, and the most commonly used in routine work are the ones that automatically locate and fit the peaks; this fit can be made in several different ways -- the most common ways are to fit a Gaussian function to each peak or simply to integrate the area under the peak, but some software go far beyond and include several small corrections to the simple Gaussian peak function, in order to compensate for secondary effects. In this work several gamma-ray spectroscopy software are compared in the task of finding and fitting the gamma-ray peaks in spectra taken with standard sources of $^{137}$Cs, $^{60}$Co, $^{133}$Ba and $^{152}$Eu. The results...

  19. Mesoscopic Model for Free Energy Landscape Analysis of DNA sequences

    CERN Document Server

    Tapia-Rojo, R; Mazo, J J; Falo, F; 10.1103/PhysRevE.86.021908

    2012-01-01

    A mesoscopic model which allows us to identify and quantify the strength of binding sites in DNA sequences is proposed. The model is based on the Peyrard-Bishop-Dauxois model for the DNA chain coupled to a Brownian particle which explores the sequence interacting more importantly with open base pairs of the DNA chain. We apply the model to promoter sequences of different organisms. The free energy landscape obtained for these promoters shows a complex structure that is strongly connected to their biological behavior. The analysis method used is able to quantify free energy differences of sites within genome sequences.

  20. Spatial charaterization of El Pardo landscape using Detrended Fluctuation analysis

    Science.gov (United States)

    Castellanos, Maria Teresa; Morato, Maria Carmen; Aguado, Pedro L.; del Monte, Juan P.; Tarquis, Ana M.

    2017-04-01

    The interactions among abiotic, biotic, and anthropic factors and their influence at different scales create a complex dynamic in landscape evolution. Scaling and multifractal analysis has the potential to characterize the landscape in terms of the statistical signature of the measure selected, in this case altitude. The study zone is a matrix of 2053 x 2053 pixels, with a resolution of 5m (25 m2 by pixel), obtained from a digital terrain model (DTM) using the latest informatics tools. This zone corresponds to homogeneous region with respect to soil characteristics and climatology but with topographic distinctive areas, known as "Monte de El Pardo". We found that the fluctuation statistics at different scales revealed a non-Gaussian character in the data. Generalized Hurst dimensions were calculated on several transects crossing the area studied exhibit multifractality in all of them within a certain range. Analysis of the directionality by means of a Generalized Hurst rose plot showed differences in scaling characteristics along river and reservoir direction and across it. The results show a growth of persistent behavior in all the directions and a clear anisotropy to be considered in bi-dimensional detrended fluctuation analysis.

  1. Characterizing structural transitions using localized free energy landscape analysis.

    Directory of Open Access Journals (Sweden)

    Nilesh K Banavali

    Full Text Available BACKGROUND: Structural changes in molecules are frequently observed during biological processes like replication, transcription and translation. These structural changes can usually be traced to specific distortions in the backbones of the macromolecules involved. Quantitative energetic characterization of such distortions can greatly advance the atomic-level understanding of the dynamic character of these biological processes. METHODOLOGY/PRINCIPAL FINDINGS: Molecular dynamics simulations combined with a variation of the Weighted Histogram Analysis Method for potential of mean force determination are applied to characterize localized structural changes for the test case of cytosine (underlined base flipping in a GTCAGCGCATGG DNA duplex. Free energy landscapes for backbone torsion and sugar pucker degrees of freedom in the DNA are used to understand their behavior in response to the base flipping perturbation. By simplifying the base flipping structural change into a two-state model, a free energy difference of upto 14 kcal/mol can be attributed to the flipped state relative to the stacked Watson-Crick base paired state. This two-state classification allows precise evaluation of the effect of base flipping on local backbone degrees of freedom. CONCLUSIONS/SIGNIFICANCE: The calculated free energy landscapes of individual backbone and sugar degrees of freedom expectedly show the greatest change in the vicinity of the flipping base itself, but specific delocalized effects can be discerned upto four nucleotide positions away in both 5' and 3' directions. Free energy landscape analysis thus provides a quantitative method to pinpoint the determinants of structural change on the atomic scale and also delineate the extent of propagation of the perturbation along the molecule. In addition to nucleic acids, this methodology is anticipated to be useful for studying conformational changes in all macromolecules, including carbohydrates, lipids, and proteins.

  2. Estimating landscape carrying capacity through maximum clique analysis.

    Science.gov (United States)

    Donovan, Therese M; Warrington, Gregory S; Schwenk, W Scott; Dinitz, Jeffrey H

    2012-12-01

    Habitat suitability (HS) maps are widely used tools in wildlife science and establish a link between wildlife populations and landscape pattern. Although HS maps spatially depict the distribution of optimal resources for a species, they do not reveal the population size a landscape is capable of supporting--information that is often crucial for decision makers and managers. We used a new approach, "maximum clique analysis," to demonstrate how HS maps for territorial species can be used to estimate the carrying capacity, N(k), of a given landscape. We estimated the N(k) of Ovenbirds (Seiurus aurocapillus) and bobcats (Lynx rufus) in an 1153-km2 study area in Vermont, USA. These two species were selected to highlight different approaches in building an HS map as well as computational challenges that can arise in a maximum clique analysis. We derived 30-m2 HS maps for each species via occupancy modeling (Ovenbird) and by resource utilization modeling (bobcats). For each species, we then identified all pixel locations on the map (points) that had sufficient resources in the surrounding area to maintain a home range (termed a "pseudo-home range"). These locations were converted to a mathematical graph, where any two points were linked if two pseudo-home ranges could exist on the landscape without violating territory boundaries. We used the program Cliquer to find the maximum clique of each graph. The resulting estimates of N(k) = 236 Ovenbirds and N(k) = 42 female bobcats were sensitive to different assumptions and model inputs. Estimates of N(k) via alternative, ad hoc methods were 1.4 to > 30 times greater than the maximum clique estimate, suggesting that the alternative results may be upwardly biased. The maximum clique analysis was computationally intensive but could handle problems with < 1500 total pseudo-home ranges (points). Given present computational constraints, it is best suited for species that occur in clustered distributions (where the problem can be

  3. Analysis of sea use landscape pattern based on GIS: a case study in Huludao, China.

    Science.gov (United States)

    Suo, Anning; Wang, Chen; Zhang, Minghui

    2016-01-01

    This study aims to analyse sea use landscape patterns on a regional scale based on methods of landscape ecology integrated with sea use spatial characteristics. Several landscape-level analysis indices, such as the dominance index, complex index, intensivity index, diversity index and sea congruency index, were established using Geographic Information System (GIS) and applied in Huludao, China. The results indicated that sea use landscape analysis indices, which were created based on the characteristics of sea use spatial patterns using GIS, are suitable to quantitatively describe the landscape patterns of sea use. They are operable tools for the landscape analysis of sea use. The sea use landscape in Huludao was dominated by fishing use with a landscape dominance index of 0.724. The sea use landscape is a complex mosaic with high diversity and plenty of fishing areas, as shown by the landscape complex index of 27.21 and the landscape diversity index of 1.25. Most sea use patches correspond to the marine functional zonation plan and the sea use congruency index is 0.89 in the fishing zone and 0.92 in the transportation zone.

  4. Analysis on sensitivity and landscape ecological spatial structure of site resources

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This article establishes a set of indicators and standards for landscape ecological sensitivity analysis of site resources by using thetheories and approaches of landscape ecology.It uses landscape diversity index( H), evenness(E), natural degree(N), contrast degree(C)to study spatial structure and landscape heterogeneity of site resources and thus provides a qualitative-quantitative evaluation method for landplanning and management of small, medium scale areas.The analysis of Yantian District, Shenzhen of China showed that Wutong Mountainbelonged to high landscape ecological sensitivity area, Sanzhoutian Reservoir and Shangping Reservoir were medium landscape sensitivity areaand high ecological sensitivity area; Dameisha and Xiaomeisha belonged to medium sensitivity area caused by the decline of natural ecologicalareas.Shatoujiao, Yantian Pier belonged to low sensitivity area but urban landscape ecological development had reshaped and influenced theirlandscape ecological roles in a great extent.Suggestions on planning, protection goals and development intensity of each site or district wereraised.

  5. Hydrological landscape analysis based on digital elevation data

    Science.gov (United States)

    Seibert, J.; McGlynn, B.; Grabs, T.; Jensco, K.

    2008-12-01

    Topography is a major factor controlling both hydrological and soil processes at the landscape scale. While this is well-accepted qualitatively, quantifying relationships between topography and spatial variations of hydrologically relevant variables at the landscape scale still remains a challenging research topic. In this presentation, we describe hydrological landscape analysis HLA) as a way to derive relevant topographic indicies to describe the spatial variations of hydrological variables at the landscape scale. We demonstrate our HLA approach with four high-resolution digital elevation models (DEMs) from Sweden, Switzerland and Montana (USA). To investigate scale effects HLA metrics, we compared DEMs of different resolutions. These LiDAR-derived DEMs of 3m, 10m, and 30m, resolution represent catchments of ~ 5 km2 ranging from low to high relief. A central feature of HLA is the flowpath-based analysis of topography and the separation of hillslopes, riparian areas, and the stream network. We included the following metrics: riparian area delineation, riparian buffer potential, separation of stream inflows into right and left bank components, travel time proxies based on flowpath distances and gradients to the channel, and as a hydrologic similarity to the hypsometric curve we suggest the distribution of elevations above the stream network (computed based on the location where a certain flow pathway enters the stream). Several of these indices depended clearly on DEM resolution, whereas this effect was minor for others. While the hypsometric curves all were S-shaped the 'hillslope-hypsometric curves' had the shape of a power function with exponents less than 1. In a similar way we separated flow pathway lengths and gradients between hillslopes and streams and compared a topographic travel time proxy, which was based on the integration of gradients along the flow pathways. Besides the comparison of HLA-metrics for different catchments and DEM resolutions we present

  6. Fundamental Study about the Landscape Estimation and Analysis by CG

    Science.gov (United States)

    Nakashima, Yoshio; Miyagoshi, Takashi; Takamatsu, Mamoru; Sassa, Kazuhiro

    In recent years, the color of advertising signboards or vending machines on the streets should be harmonized with the surrounding landscape. In this study, we investigated how the colors (red and white) of the vending machines virtually installed by CG would affect the traditional landscape. 20 subjects estimated landscape samples in Hida-Furukawa by the SD technique. The result of our experiment shows that the vending machines have great influence on the surrounding landscape. On the other hand, we have confirmed that they can harmonize with the circumference landscape by the color to use.

  7. Parametric resonance in the early Universe—a fitting analysis

    Science.gov (United States)

    Figueroa, Daniel G.; Torrentí, Francisco

    2017-02-01

    Particle production via parametric resonance in the early Universe, is a non-perturbative, non-linear and out-of-equilibrium phenomenon. Although it is a well studied topic, whenever a new scenario exhibits parametric resonance, a full re-analysis is normally required. To avoid this tedious task, many works present often only a simplified linear treatment of the problem. In order to surpass this circumstance in the future, we provide a fitting analysis of parametric resonance through all its relevant stages: initial linear growth, non-linear evolution, and relaxation towards equilibrium. Using lattice simulations in an expanding grid in 3+1 dimensions, we parametrize the dynamics' outcome scanning over the relevant ingredients: role of the oscillatory field, particle coupling strength, initial conditions, and background expansion rate. We emphasize the inaccuracy of the linear calculation of the decay time of the oscillatory field, and propose a more appropriate definition of this scale based on the subsequent non-linear dynamics. We provide simple fits to the relevant time scales and particle energy fractions at each stage. Our fits can be applied to post-inflationary preheating scenarios, where the oscillatory field is the inflaton, or to spectator-field scenarios, where the oscillatory field can be e.g. a curvaton, or the Standard Model Higgs.

  8. Self-dissimilar landscapes: Revealing the signature of geologic constraints on landscape dissection via topologic and multi-scale analysis

    Science.gov (United States)

    Danesh-Yazdi, Mohammad; Tejedor, Alejandro; Foufoula-Georgiou, Efi

    2017-10-01

    Climatic or geologic controls, such as tectonics or glacial drainage, might impose constraints on landscape self-organization resulting in spatial patterns of rivers and valleys which do not obey the typical self-similar relationships found in most landscapes. The goal of this study is to quantify how such geologic constraints express themselves on channel network topology, spatial heterogeneity of drainage patterns, and emergence of preferred scales of landscape dissection. We use as an example a basin located in the Upper Midwestern United States where successive glaciations over the past thousand years have led to a pronounced spatially anisotropic channel network structure which defeats most scaling laws of fluvial landscapes. This is contrasted with another river basin in the North-Central U.S. which has been organized under the absence of major geologic influences and follows a typical self-similar channel network organization. We show how the geologic constraints have imposed a competition for space which is captured in the slope-local drainage density probabilistic structure, in the failure of self-similarity in basin-wide river network topology, and in the length-area scaling relationship being not typical of fluvial landscapes. Via a two-dimensional wavelet analysis and synthesis, we demonstrate the occurrence of a gap in the power spectrum which corresponds to the presence of preferred scales of organization, and characterize them through multi-scale detrending. The developed methodologies can be useful in advancing our geomorphologic understanding of how external controls might manifest themselves in creating a landscape dissection that is outside the norm and how this dissection can be studied objectively for understanding cause and effect.

  9. National logistics working groups: A landscape analysis study.

    Science.gov (United States)

    Leab, Dorothy; Schreiber, Benjamin; Kasonde, Musonda; Bessat, Olivia; Bui, Son; Loisel, Carine

    2017-04-19

    Several countries have acknowledged the contributions made by national logistics working groups (NLWG) to ensure equitable access to the expanded program on immunization's (EPI) vaccines against preventable diseases. In order to provide key insights to the United Nations Children's Fund (UNICEF) and the World Health Organization (WHO) supply chain hub - as well as other players, including national EPI - a landscape analysis study was conducted from September 2015 to February 2016. This is a cross-sectional survey taken by 43 countries that combines qualitative and quantitative approaches. Data was collected through a desk review, consultation, interviews, and distance questioning. References and guidance were used to determine and specify the underlying mechanisms of NLWGs. The key findings are:This study has provided a general overview of the status of NLWGs for immunization in various countries. Based on the key insights of the study, technical assistance needs have been identified, and immunization partners will be required to help countries create and reinforce their NLWGs.

  10. PyFACT: Python and FITS analysis for Cherenkov telescopes

    Science.gov (United States)

    Raue, Martin; Deil, Christoph

    2012-12-01

    Ground-based very-high energy (VHE; E>100 GeV) gamma-ray astronomy is growing from being conducted by small teams in closed collaborations into a full-fledged branch of astronomy with open observatories. This is best illustrated by the number of known sources: it increased by one order of magnitude in the past ten years, from 10 in the year 2000 to more than 100 in 2010. It is expected that this trend will continue with the next-generation instrument Cherenkov Telescope Array (CTA). This transformation has a profound impact on the data format and analysis of Imaging Atmospheric Cherenkov Telescopes (IACTs). Up to now, IACT data analysis was an internal task performed by specialists with no public access to the data or software. In the future, a large community of VHE astronomers from different scientific topics should be enabled to work with the data. Ease of use, compatibility, and integration with existing astronomy standards and tools will be key. In this contribution, a collection of Python tools for the analysis of data in FITS format (PyFACT; Python and FITS Analysis for Cherenkov Telescopes) is presented, which connects with existing tools like xspec, sherpa, and ds9. The package is available as open source (https://github.com/mraue/pyfact, comments and contributions welcome). Advantages of the chosen ansatz are discussed and implications for future observatories and data archival are presented.

  11. Simplified QCD fit method for BSM analysis of HERA data

    CERN Document Server

    Turkot, Oleksii; Zarnecki, Aleksander Filip

    2016-01-01

    The high-precision HERA data can be used as an input to a QCD analysis within the DGLAP formalism to obtain the detailed description of the proton structure in terms of the parton distribution functions (PDFs). However, when searching for Beyond Standard Model (BSM) contributions in the data one should take into account the possibility that the PDF set may already have been biased by partially or totally absorbing previously unrecognised new physics contributions. The ZEUS Collaboration has proposed a new approach to the BSM analysis of the inclusive $ep$ data based on the simultaneous QCD fits of parton distribution functions together with contributions of new physics processes. Unfortunately, limit setting procedure in the frequentist approach is very time consuming in this method, as full QCD analysis has to be repeated for numerous data replicas. We describe a simplified approach, based on the Taylor expansion of the cross section predictions in terms of PDF parameters, which allowed us to reduce the calc...

  12. Integrating landscape analysis and planning: a multi-scale approach for oriented management of tourist recreation.

    Science.gov (United States)

    de Aranzabal, Itziar; Schmitz, María F; Pineda, Francisco D

    2009-11-01

    Tourism and landscape are interdependent concepts. Nature- and culture-based tourism are now quite well developed activities and can constitute an excellent way of exploiting the natural resources of certain areas, and should therefore be considered as key objectives in landscape planning and management in a growing number of countries. All of this calls for careful evaluation of the effects of tourism on the territory. This article focuses on an integrated spatial method for landscape analysis aimed at quantifying the relationship between preferences of visitors and landscape features. The spatial expression of the model relating types of leisure and recreational preferences to the potential capacity of the landscape to meet them involves a set of maps showing degrees of potential visitor satisfaction. The method constitutes a useful tool for the design of tourism planning and management strategies, with landscape conservation as a reference.

  13. FRAGSTATS: spatial pattern analysis program for quantifying landscape structure.

    Science.gov (United States)

    Kevin McGarigal; Barbara J. Marks

    1995-01-01

    This report describes a program, FRAGSTATS, developed to quantify landscape structure. FRAGSTATS offers a comprehensive choice of landscape metrics and was designed to be as versatile as possible. The program is almost completely automated and thus requires little technical training. Two separate versions of FRAGSTATS exist: one for vector images and one for raster...

  14. Effects of Landscape Fragmentation on Animals Fitness%景观破碎化对动物适合度的影响研究综述

    Institute of Scientific and Technical Information of China (English)

    扎史其; 格玛江初

    2013-01-01

    景观破碎化是生物多样性下降的主要原因之一,景观破碎化已成为保护生物学和生态学的中心问题之一。通常以岛屿生物地理学、异质种群生物学和景观生态学的理论来解释景观破碎化的生态学效应。以往研究表明,生境破碎化对动物适合度造成严重影响。文章通过综合文献,论述景观破碎化对动物适合度的影响,分析影响动物适合度的各项指标,包括物种生存能力,繁殖能力和子代存活能力。同时探讨研究中存在的问题,为物种的保护提出建议,并指出今后研究的主要方法、亟待解决的问题和研究热点。%As one of major factors attributed to the loss of biodiversity , landscape fragmentation has be-come one of central issues in conservation of biology and ecology .Theories of island biogeography , meta-population and landscape ecology have been taken to mainly explain effects of landscape fragmentation , some research shows that habitat fragmentation has mainly changed the fitness of animals .In this paper , by using comprehensive literature , the impact of the landscape fragmentation on fitness of animals has been discussed , and each factor including species , viability , reproductive ability and offspring viability also been analyzed .Study also discussed the problems , and addressed recommendations for the species protection , the methods of future research and research focus .

  15. Bioelectrical Impedance Vector Analysis and Muscular Fitness in Healthy Men

    Science.gov (United States)

    Rodríguez-Rodríguez, Fernando; Cristi-Montero, Carlos; González-Ruíz, Katherine; Correa-Bautista, Jorge Enrique; Ramírez-Vélez, Robinson

    2016-01-01

    Muscle strength can define the general muscular fitness (MF) measurable through hand-grip strength (HG), which is a factor that relates to the health of people of different ages. In this study we evaluated the muscle strength together with a bioimpedance electric analysis in 223 healthy Colombian adult subjects. The bioelectrical impedance vector analysis (BIVA) was conducted to determine the resistance (R), reactance (Xc) and phase angle (PhA). We classified the subjects into three groups (for tertiles), obtaining lower values of R and Xc in subjects with lower HG, plus a high correlation between PhA and HG. An increase in the level of PhA is associated with a high level of MF in a sample of healthy Latin American adult men. The BIVA’s parameters and PhA are a potentially effective preventive measure to be integrated into routine screening in the clinical setting. PMID:27384579

  16. Bioelectrical Impedance Vector Analysis and Muscular Fitness in Healthy Men

    Directory of Open Access Journals (Sweden)

    Fernando Rodríguez-Rodríguez

    2016-07-01

    Full Text Available Muscle strength can define the general muscular fitness (MF measurable through hand-grip strength (HG, which is a factor that relates to the health of people of different ages. In this study we evaluated the muscle strength together with a bioimpedance electric analysis in 223 healthy Colombian adult subjects. The bioelectrical impedance vector analysis (BIVA was conducted to determine the resistance (R, reactance (Xc and phase angle (PhA. We classified the subjects into three groups (for tertiles, obtaining lower values of R and Xc in subjects with lower HG, plus a high correlation between PhA and HG. An increase in the level of PhA is associated with a high level of MF in a sample of healthy Latin American adult men. The BIVA’s parameters and PhA are a potentially effective preventive measure to be integrated into routine screening in the clinical setting.

  17. Parametric Resonance in the Early Universe - A Fitting Analysis

    CERN Document Server

    Figueroa, Daniel G.

    2017-01-01

    Particle production via parametric resonance in the early Universe, is a non-perturbative, non-linear and out-of-equilibrium phenomenon. Although it is a well studied topic, whenever a new scenario exhibits parametric resonance, a full re-analysis is normally required. To avoid this tedious task, many works present often only a simplified linear treatment of the problem. In order to surpass this circumstance in the future, we provide a fitting analysis of parametric resonance through all its relevant stages: initial linear growth, non-linear evolution, and relaxation towards equilibrium. Using lattice simulations in an expanding grid in $3+1$ dimensions, we parametrise the dynamics' outcome scanning over the relevant ingredients: role of the oscillatory field, particle coupling strength, initial conditions, and background expansion rate. We emphasise the inaccuracy of the linear calculation of the decay time of the oscillatory field, and propose a more appropriate definition of this scale based on the subsequ...

  18. Integrated dynamic landscape analysis and modeling system (IDLAMS) : installation manual.

    Energy Technology Data Exchange (ETDEWEB)

    Li, Z.; Majerus, K. A.; Sundell, R. C.; Sydelko, P. J.; Vogt, M. C.

    1999-02-24

    The Integrated Dynamic Landscape Analysis and Modeling System (IDLAMS) is a prototype, integrated land management technology developed through a joint effort between Argonne National Laboratory (ANL) and the US Army Corps of Engineers Construction Engineering Research Laboratories (USACERL). Dr. Ronald C. Sundell, Ms. Pamela J. Sydelko, and Ms. Kimberly A. Majerus were the principal investigators (PIs) for this project. Dr. Zhian Li was the primary software developer. Dr. Jeffrey M. Keisler, Mr. Christopher M. Klaus, and Mr. Michael C. Vogt developed the decision analysis component of this project. It was developed with funding support from the Strategic Environmental Research and Development Program (SERDP), a land/environmental stewardship research program with participation from the US Department of Defense (DoD), the US Department of Energy (DOE), and the US Environmental Protection Agency (EPA). IDLAMS predicts land conditions (e.g., vegetation, wildlife habitats, and erosion status) by simulating changes in military land ecosystems for given training intensities and land management practices. It can be used by military land managers to help predict the future ecological condition for a given land use based on land management scenarios of various levels of training intensity. It also can be used as a tool to help land managers compare different land management practices and further determine a set of land management activities and prescriptions that best suit the needs of a specific military installation.

  19. A meta-analysis of crop pest and natural enemy response to landscape complexity.

    Science.gov (United States)

    Chaplin-Kramer, Rebecca; O'Rourke, Megan E; Blitzer, Eleanor J; Kremen, Claire

    2011-09-01

    Many studies in recent years have investigated the relationship between landscape complexity and pests, natural enemies and/or pest control. However, no quantitative synthesis of this literature beyond simple vote-count methods yet exists. We conducted a meta-analysis of 46 landscape-level studies, and found that natural enemies have a strong positive response to landscape complexity. Generalist enemies show consistent positive responses to landscape complexity across all scales measured, while specialist enemies respond more strongly to landscape complexity at smaller scales. Generalist enemy response to natural habitat also tends to occur at larger spatial scales than for specialist enemies, suggesting that land management strategies to enhance natural pest control should differ depending on whether the dominant enemies are generalists or specialists. The positive response of natural enemies does not necessarily translate into pest control, since pest abundances show no significant response to landscape complexity. Very few landscape-scale studies have estimated enemy impact on pest populations, however, limiting our understanding of the effects of landscape on pest control. We suggest focusing future research efforts on measuring population dynamics rather than static counts to better characterise the relationship between landscape complexity and pest control services from natural enemies.

  20. Activity Landscape Plotter: A Web-based Application for the Analysis of Structure-Activity Relationships.

    Science.gov (United States)

    González-Medina, Mariana; Méndez-Lucio, Oscar; Medina-Franco, Jose Luis

    2017-02-24

    Activity landscape modeling is a powerful method for the quantitative analysis of structure-activity relationships. This cheminformatics area is in continuous growth and several quantitative and visual approaches are constantly being developed. However, these approaches often fall into disuse due to their limited access. Herein, we present Activity Landscape Plotter as the first freely available web-based tool to automatically analyze structure-activity relationships of compound data sets. Based on the concept of activity landscape modeling, the online service performs pair-wise structure and activity relationships from an input data set supplied by the user. For visual analysis, Activity Landscape Plotter generates Structure-Activity Similarity and Dual Activity Difference maps. The user can interactively navigate through the maps and export all the pairwise structure-activity information as comma delimited files. Activity Landscape Plotter is freely accessible at https://unam-shiny-difacquim.shinyapps.io/ActLSmaps/.

  1. Thermal Infrared Remote Sensing for Analysis of Landscape Ecological Processes: Methods and Applications

    Science.gov (United States)

    Quattrochi, Dale A.; Luvall, Jeffrey C.

    1998-01-01

    Thermal Infrared (TIR) remote sensing data can provide important measurements of surface energy fluxes and temperatures, which are integral to understanding landscape processes and responses. One example of this is the successful application of TIR remote sensing data to estimate evapotranspiration and soil moisture, where results from a number of studies suggest that satellite-based measurements from TIR remote sensing data can lead to more accurate regional-scale estimates of daily evapotranspiration. With further refinement in analytical techniques and models, the use of TIR data from airborne and satellite sensors could be very useful for parameterizing surface moisture conditions and developing better simulations of landscape energy exchange over a variety of conditions and space and time scales. Thus, TIR remote sensing data can significantly contribute to the observation, measurement, and analysis of energy balance characteristics (i.e., the fluxes and redistribution of thermal energy within and across the land surface) as an implicit and important aspect of landscape dynamics and landscape functioning. The application of TIR remote sensing data in landscape ecological studies has been limited, however, for several fundamental reasons that relate primarily to the perceived difficulty in use and availability of these data by the landscape ecology community, and from the fragmentation of references on TIR remote sensing throughout the scientific literature. It is our purpose here to provide evidence from work that has employed TIR remote sensing for analysis of landscape characteristics to illustrate how these data can provide important data for the improved measurement of landscape energy response and energy flux relationships. We examine the direct or indirect use of TIR remote sensing data to analyze landscape biophysical characteristics, thereby offering some insight on how these data can be used more robustly to further the understanding and modeling of

  2. Urban-rural gradient detection using multivariate spatial analysis and landscape metrics

    Directory of Open Access Journals (Sweden)

    Marco Vizzari

    2013-09-01

    Full Text Available The gradient approach allows for an innovative representation of landscape composition and configuration not presupposing spatial discontinuities typical of the conventional methods of analysis. Also the urban-rural dichotomy can be better understood through a continuous landscape gradient whose characterization changes accordingly to natural and anthropic variables taken into account and to the spatio-temporal scale adopted for the study. The research was aimed at the analysis of an urban-rural gradient within a study area located in central Italy, using spatial indicators associated with urbanization, agriculture and natural elements. A multivariate spatial analysis (MSA of such indicators enabled the identification of urban, agricultural and natural dominated areas, as well as specific landscape transitions where the most relevant relationships between agriculture and other landscape components were detected. Landscapes derived from MSA were studied by a set of key landscape pattern metrics within a framework oriented to the structural characterization of the whole urban-rural gradient. The results showed two distinct sub-gradients: one urban-agricultural and one agricultural-natural, both characterized by different fringe areas. This application highlighted how the proposed methodology can represent a reliable approach supporting modern landscape planning and management.

  3. ANALYSIS OF ENVIRONMENTAL FRAGILITY USING MULTI-CRITERIA ANALYSIS (MCE FOR INTEGRATED LANDSCAPE ASSESSMENT

    Directory of Open Access Journals (Sweden)

    Abimael Cereda Junior

    2014-01-01

    Full Text Available The Geographic Information Systems brought greater possibilitie s to the representation and interpretation of the landscap e as well as the integrated a nalysis. However, this approach does not dispense technical and methodological substan tiation for achieving the computational universe. This work is grounded in ecodynamic s and empirical analysis of natural and anthr opogenic environmental Fragility a nd aims to propose and present an integrated paradigm of Multi-criteria Analysis and F uzzy Logic Model of Environmental Fragility, taking as a case study of the Basin of Monjolinho Stream in São Carlos-SP. The use of this methodology allowed for a reduct ion in the subjectivism influences of decision criteria, which factors might have its cartographic expression, respecting the complex integrated landscape.

  4. Pottery in the landscape: Ceramic analysis at the city-kingdom of Idalion, Cyprus

    Directory of Open Access Journals (Sweden)

    Bartusewich, Rebecca

    2012-04-01

    Full Text Available The ancient site of Idalion, Cyprus has a landscape dominated by two acropoleis containing sacred sites. The plain below is the location of domestic occupation. I have petrologically analyzed 45 ceramics from the domestic area and one sacred area and found that while the sacred spaces dominate the landscape, ceramics were not produced/chosen differently for the sacred area over the domestic area. The visual proximity of the sacred and the everyday seems to indicate cohesion in the social and natural landscape. The preliminary petrological analysis of pottery from Idalion has shown, thus far, that the sacred and profane are intertwined.

  5. Bayesian item fit analysis for unidimensional item response theory models.

    Science.gov (United States)

    Sinharay, Sandip

    2006-11-01

    Assessing item fit for unidimensional item response theory models for dichotomous items has always been an issue of enormous interest, but there exists no unanimously agreed item fit diagnostic for these models, and hence there is room for further investigation of the area. This paper employs the posterior predictive model-checking method, a popular Bayesian model-checking tool, to examine item fit for the above-mentioned models. An item fit plot, comparing the observed and predicted proportion-correct scores of examinees with different raw scores, is suggested. This paper also suggests how to obtain posterior predictive p-values (which are natural Bayesian p-values) for the item fit statistics of Orlando and Thissen that summarize numerically the information in the above-mentioned item fit plots. A number of simulation studies and a real data application demonstrate the effectiveness of the suggested item fit diagnostics. The suggested techniques seem to have adequate power and reasonable Type I error rate, and psychometricians will find them promising.

  6. English in the Japanese Linguistic Landscape: A Motive Analysis

    Science.gov (United States)

    Rowland, Luke

    2016-01-01

    Linguistic landscape (LL) research seeks to account for the visible displays of multilingualism on public signage. While surveys of signage in the LL produce quantitative descriptions of language contact in a given area, such analyses shed little light on people's interpretations of multilingual signs. Moreover, even within more qualitative…

  7. An analysis on the water landscape design of residential area

    Institute of Scientific and Technical Information of China (English)

    张庆雷

    2012-01-01

    Water is an essential factor in our daily life and one of the most vivid scenery in the nature. Water may modify the local atmosphere, purify the air, irrigate plants, breed fish and prevent from fire, all of which are the important factors for the landscape design.

  8. GIFtS: annotation landscape analysis with GeneCards

    Directory of Open Access Journals (Sweden)

    Dalah Irina

    2009-10-01

    Full Text Available Abstract Background Gene annotation is a pivotal component in computational genomics, encompassing prediction of gene function, expression analysis, and sequence scrutiny. Hence, quantitative measures of the annotation landscape constitute a pertinent bioinformatics tool. GeneCards® is a gene-centric compendium of rich annotative information for over 50,000 human gene entries, building upon 68 data sources, including Gene Ontology (GO, pathways, interactions, phenotypes, publications and many more. Results We present the GeneCards Inferred Functionality Score (GIFtS which allows a quantitative assessment of a gene's annotation status, by exploiting the unique wealth and diversity of GeneCards information. The GIFtS tool, linked from the GeneCards home page, facilitates browsing the human genome by searching for the annotation level of a specified gene, retrieving a list of genes within a specified range of GIFtS value, obtaining random genes with a specific GIFtS value, and experimenting with the GIFtS weighting algorithm for a variety of annotation categories. The bimodal shape of the GIFtS distribution suggests a division of the human gene repertoire into two main groups: the high-GIFtS peak consists almost entirely of protein-coding genes; the low-GIFtS peak consists of genes from all of the categories. Cluster analysis of GIFtS annotation vectors provides the classification of gene groups by detailed positioning in the annotation arena. GIFtS also provide measures which enable the evaluation of the databases that serve as GeneCards sources. An inverse correlation is found (for GIFtS>25 between the number of genes annotated by each source, and the average GIFtS value of genes associated with that source. Three typical source prototypes are revealed by their GIFtS distribution: genome-wide sources, sources comprising mainly highly annotated genes, and sources comprising mainly poorly annotated genes. The degree of accumulated knowledge for a

  9. An Entropy-Based Contagion Index and Its Sampling Properties for Landscape Analysis

    Directory of Open Access Journals (Sweden)

    Bernard R. Parresol

    2014-03-01

    Full Text Available Studies of spatial patterns of landscapes are useful to quantify human impact, predict wildlife effects, or describe various landscape features. A robust landscape index should quantify two components of landscape diversity: composition and configuration. One category of landscape index is the contagion index. Some landscape ecologists promote the use of relative contagion indices. It is demonstrated, using simulated landscapes, that relativized contagion indices are mathematically untenable. A new entropy contagion index (Γ is developed. Distributional properties of Γ^ are derived. It is shown to be asymptotically unbiased, consistent, and asymptotically normally distributed. A variance formula for Γ^ is derived using the delta method. As an application, the pattern and changes in forest types across four soil-geologic landform strata were analyzed on the 80,000 ha Savannah River Site in South Carolina, USA. One-way analysis of variance was used for hypothesis testing of contagion among strata. The differences in contagion across the strata provide insight to managers to meet structural objectives.

  10. Integration of Bayesian analysis for eutrophication prediction and assessment in a landscape lake.

    Science.gov (United States)

    Yang, Likun; Zhao, Xinhua; Peng, Sen; Zhou, Guangyu

    2015-01-01

    Eutrophication models have been widely used to assess water quality in landscape lakes. Because flow rate in landscape lakes is relatively low and similar to that of natural lakes, eutrophication is more dominant in landscape lakes. To assess the risk of eutrophication in landscape lakes, a set of dynamic equations was developed to simulate lake water quality for total nitrogen (TN), total phosphorous (TP), dissolve oxygen (DO) and chlorophyll a (Chl a). Firstly, the Bayesian calibration results were described. Moreover, the ability of the model to reproduce adequately the observed mean patterns and major cause-effect relationships for water quality conditions in landscape lakes were presented. Two loading scenarios were used. A Monte Carlo algorithm was applied to calculate the predicated water quality distributions, which were used in the established hierarchical assessment system for lake water quality risk. The important factors affecting the lake water quality risk were defined using linear regression analysis. The results indicated that the variations in the landscape lake receiving recharge water quality caused considerable landscape lake water quality risk in the surrounding area. Moreover, the Chl a concentration in lake water was significantly affected by TP and TN concentrations; the lake TP concentration was the limiting factor for growth of plankton in lake water. The lake water TN concentration provided the basic nutritional requirements. Lastly, lower TN and TP concentrations in the receiving recharge water caused increased lake water quality risk.

  11. Modeling the Habitat Range of Phototrophic Microorganisms in Yellowstone National Park: Toward the Development of a Comprehensive Fitness Landscape

    Directory of Open Access Journals (Sweden)

    Eric eBoyd

    2012-06-01

    Full Text Available The extent to which geochemical variation constrains the distribution of phototrophic metabolisms was modeled based on 439 observations in geothermal springs in Yellowstone National Park (YNP, Wyoming. Generalized additive models (GAMs were developed to predict the distribution of photosynthesis as a function of spring temperature, pH, and total sulfide. GAMs comprised of temperature explained 42.7% of the variation in the distribution of phototrophic metabolisms whereas GAMs comprised of sulfide and pH explained 20.7% and 11.7% of the variation, respectively. These results suggest that of the measured variables, temperature is the primary constraint on the distribution of phototrophic metabolism in YNP. GAMs comprised of multiple variables explained a larger percentage of the variation in the distribution of phototrophic metabolism, indicating additive interactions among variables. A GAM that combined temperature and sulfide explained the greatest variation in the dataset (54.8% while minimizing the introduction of degrees of freedom. In an effort to verify the extent to which phototroph distribution reflects constraints on activity, we examined the influence of sulfide and temperature on dissolved inorganic carbon (DIC uptake rates under both light and dark conditions. Light-driven DIC uptake decreased systematically with increasing concentrations of sulfide in acidic, algal-dominated systems, but was unaffected in alkaline, bacterial-dominated systems. In both alkaline and acidic systems, light-driven DIC uptake was suppressed in cultures incubated at temperatures 10°C greater than their in situ temperature. Collectively, these results suggest that the habitat range of phototrophs in YNP springs, specifically that of cyanobacteria and algae, largely results from constraints imposed by temperature and sulfide on the activity and fitness of these populations, a finding that is consistent with the predictions from GAMs.

  12. Geomorphology applied to landscape analysis for planning and management of natural spaces. Case study: Las Batuecas-S. de Francia and Quilamas natural parks, (Salamanca, Spain).

    Science.gov (United States)

    Martínez-Graña, A M; Silva, P G; Goy, J L; Elez, J; Valdés, V; Zazo, C

    2017-04-15

    Geomorphology is fundamental to landscape analysis, as it represents the main parameter that determines the land spatial configuration and facilitates reliefs classification. The goal of this article is the elaboration of thematic maps that enable the determination of different landscape units and elaboration of quality and vulnerability synthetic maps for landscape fragility assessment prior to planning human activities. For two natural spaces, the final synthetic maps were created with direct (visual-perceptual features) and indirect (cartographic models and 3D simulations) methods from thematic maps with GIS technique. This enabled the creation of intrinsic and extrinsic landscape quality maps showing sectors needing most preservation, as well as intrinsic and extrinsic landscape fragility maps (environment response capacity or vulnerability towards human actions). The resulting map shows absorption capacity for areas of maximum and/or minimum human intervention. Sectors of high absorption capacity (minimum need for preservation) are found where the incidence of human intervention is minimum: escarpment bottoms, fitted rivers, sinuous high lands with thick vegetation coverage and valley interiors, or those areas with high landscape quality, low fragility and high absorption capacity, whose average values are found across lower hillsides of some valleys, and sectors with low absorption capacity (areas needing most preservation) found mainly in the inner parts of natural spaces: peaks and upper hillsides, synclines flanks and scattered areas. For the integral analysis of landscape, a mapping methodology has been set. It comprises a valid criterion for rational and sustainable planning, management and protection of natural spaces. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Perceptions of Fitness Professionals regarding Fitness Occupations and Careers: A Phenomenological Analysis

    Directory of Open Access Journals (Sweden)

    Ant\\u00F3nio Rosado

    2014-01-01

    Full Text Available El propósito de este estudio fue examinar las percepciones de su profesión y las carreras profesionales de fitness . Dieciséis profesores portugueses de aptitud física ( edad M = 28 años participaron en las entrevistas semi-estructuradas con respecto a su percepción de su profesión. Los datos se analizaron usando temáticamente interpretativo fenomenológico Análisis (Smith y Osborn , 2003 . Se pidió a los participantes a considerar temas como su función profesional , perfil y habilidades ; social, el grupo y los factores organizativos ; factores personales relacionados con su profesión y al mercado de trabajo ; y las perspectivas sociales y financieros de theirjob . Del análisis de las entrevistas, una lista completa de las sentencias se elaboró ​​, expresar opiniones y ideasby los entrevistados. Estos se organizaron y se incluyen en las categorías pre - definidas , dando lugar a una red de sub-temas . Este estudio ha puesto de manifiesto algunas de las características propias de la profesión que debe ser considerado a un nivel más general , con implicaciones importantes en la orientación profesional dadas a los jóvenes, en la organización de los flujos de trabajo , y en la formación y organización de la actividad profesional como todo.

  14. MULTI-TEMPORAL ANALYSIS OF LANDSCAPES AND URBAN AREAS

    Directory of Open Access Journals (Sweden)

    E. Nocerino

    2012-07-01

    Full Text Available This article presents a 4D modelling approach that employs multi-temporal and historical aerial images to derive spatio-temporal information for scenes and landscapes. Such imagery represent a unique data source, which combined with photo interpretation and reality-based 3D reconstruction techniques, can offer a more complete modelling procedure because it adds the fourth dimension of time to 3D geometrical representation and thus, allows urban planners, historians, and others to identify, describe, and analyse changes in individual scenes and buildings as well as across landscapes. Particularly important to this approach are historical aerial photos, which provide data about the past that can be collected, processed, and then integrated as a database. The proposed methodology employs both historical (1945 and more recent (1973 and 2000s aerial images from the Trentino region in North-eastern Italy in order to create a multi-temporal database of information to assist researchers in many disciplines such as topographic mapping, geology, geography, architecture, and archaeology as they work to reconstruct building phases and to understand landscape transformations (Fig. 1.

  15. Assessment and analysis components of physical fitness of students

    Directory of Open Access Journals (Sweden)

    Kashuba V.A.

    2012-08-01

    Full Text Available It is assessed components of a physical fitness of students. It is analyzed the internal and external factors affecting the quality of life for students. The study involved more than 200 students. Found that students represent a category of people with elevated risk factors, which include the nervous and mental tension, constant violations of the food, work and leisure, in their way of life there is a lack of care about their health. It is noted that the existing approaches to promoting physical fitness of students are inefficient and require the development and implementation of brand new contemporary theoretical foundations and practical approaches to the problem of increasing the activity of students. It is proved that sold today in the practice of higher education forms, methods, learning tools do not allow to fully ensure the implementation of approaches to promoting physical fitness of students do not meet the requirements for the preparation of the modern health professional.

  16. Kalman Filter Track Fits and Track Breakpoint Analysis

    CERN Document Server

    Astier, Pierre; Cousins, R D; Letessier-Selvon, A A; Popov, B A; Vinogradova, T G; Astier, Pierre; Cardini, Alessandro; Cousins, Robert D.; Letessier-Selvon, Antoine; Popov, Boris A.; Vinogradova, Tatiana

    2000-01-01

    We give an overview of track fitting using the Kalman filter method in the NOMAD detector at CERN, and emphasize how the wealth of by-product information can be used to analyze track breakpoints (discontinuities in track parameters caused by scattering, decay, etc.). After reviewing how this information has been previously exploited by others, we describe extensions which add power to breakpoint detection and characterization. We show how complete fits to the entire track, with breakpoint parameters added, can be easily obtained from the information from unbroken fits. Tests inspired by the Fisher F-test can then be used to judge breakpoints. Signed quantities (such as change in momentum at the breakpoint) can supplement unsigned quantities such as the various chisquares. We illustrate the method with electrons from real data, and with Monte Carlo simulations of pion decays.

  17. Evaluation of the landscape surrounding northern bobwhite nest sites: A multiscale analysis

    Science.gov (United States)

    White, C.G.; Schweitzer, Sara H.; Moore, C.T.; Parnell, I.B.; Lewis-Weis, L.A.

    2005-01-01

    Implementation of the Conservation Reserve Program (CRP) altered the interspersion and abundance of patches of different land-cover types in landscapes of the southeastern United States. Because northern bobwhites (Colinus virginianus) are experiencing significant population declines throughout most of their range, including the Southeast, it is critical to understand the impacts of landscape-scale changes in habitat on their reproductive rates. Our objective was to identify components of landscape structure important in predicting nest site selection by bobwhites at different spatial scales in the Upper Coastal Plain of Georgia. We used a Geographic Information System (GIS) and spatial analysis software to calculate metrics of landscape structure near bobwhite nest sites. Logistic regression was used to model the relationship of nest sites to structure within the surrounding landscape at 4 spatial scales. We found that patch density and open-canopy planted pine were consistently important predictor variables at multiple scales, and other variables were important at various scales. The density of different patch types could be increased by thinning rows of pines in large monotypic stands of closed-canopy planted pine stands. Thinning and creating openings in CRP pine plantations should provide increased nesting opportunities for bobwhites. We interpret the support for other variables in our analysis as an indication that various patch configuration lead to different combinations of landscape structure that provide an acceptable range of habitat conditions for bobwhites.

  18. Gradient analysis of landscape spatial and temporal pattern changes in Beijing metropolitan area

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The gradient based landscape metrics analysis is now widely used to study the landscape pattern changes in respond to the urbanization.In order to discover the trend of spatio-temporal changes in Beijing metropolitan area during the past 15 years,several landscape metrics are computed using a moving window along a 96 km long transect across Beijing metropolitan area from west to east.Specially,the spatial extent of sub-landscape,which is determined by the moving window’s size,is profoundly examined.The results show that the metrics varies smoothly and regularly along the selected transect when the window size is greater than 6 km×6 km,and irregularly fluctuated for the smaller window size,that the spatial and temporal landscape characteristics of Beijing city match the hypothetical framework of spatio-temporal urban sprawl in the form of alternating processes of diffusion and coalescence well,and that some new trends of the urban sprawl style in Beijing metropolitan area,such as leap-frog manner,are also detected by the gradient landscape analysis.

  19. A Landscape Analysis to Understand Orientation of Honey Bee (Hymenoptera: Apidae) Drones in Puerto Rico.

    Science.gov (United States)

    Galindo-Cardona, A; Monmany, A C; Diaz, G; Giray, T

    2015-08-01

    Honey bees [Apis mellifera L. (Apidae, Hymenoptera)] show spatial learning behavior or orientation, in which animals make use of structured home ranges for their daily activities. Worker (female) orientation has been studied more extensively than drone (male) orientation. Given the extensive and large flight range of drones as part of their reproductive biology, the study of drone orientation may provide new insight on landscape features important for orientation. We report the return rate and orientation of drones released at three distances (1, 2, and 4 km) and at the four cardinal points from an apiary located in Gurabo, Puerto Rico. We used high-resolution aerial photographs to describe landscape characteristics at the releasing sites and at the apiary. Analyses of variance were used to test significance among returning times from different distances and directions. A principal components analysis was used to describe the landscape at the releasing sites and generalized linear models were used to identify landscape characteristics that influenced the returning times of drones. Our results showed for the first time that drones are able to return from as far as 4 km from the colony. Distance to drone congregation area, orientation, and tree lines were the most important landscape characteristics influencing drone return rate. We discuss the role of landscape in drone orientation.

  20. Analysis of Land Cover Changes in the Central Part of Isfahan (Iran Using Landscape Metrics

    Directory of Open Access Journals (Sweden)

    N. Bihamta Toosi

    2014-03-01

    Full Text Available Knowledge about long-term land cover/use changes is essential for evaluating and predicting their consequent problems by urban managers and policymakers. Remote sensing with landscape metrics is an effective tool for monitoring these changes in urban cores and their peripheral areas. During the recent decades, industrial and urban growth, and immigration of people into Isfahan metropolitan area (Iran have affected its surrounding environment. The objective of this research was to quantify the changes of landscape patterns in the center of Isfahan during the last two decades. For monitoring spatial pattern changes, land use and cover maps of the area were prepared using supervised maximum likelihood classification of Landsat Thematic Mapper (TM images taken in 1990 and 2010. In order to quantify the changes in landscape patterns during this period, we used several landscape metrics of each class type and total landscape. These metrics included percentage of landscape (PLAND, number of patches (NP, mean patch size (MPS, patch density (PD, largest patch index (LPI, mean nearest neighbor (MNN, contagion (CONTAG, and Shannon’s diversity index (SHDI. The results of this study showed that the proportion of urban area and bare land significantly increased during the study period. Decreased mean patch area for agriculture and undeveloped land uses indicated that the landscape had been more fragmented in these two classes. The synoptic analysis of selected metrics for landscape level indicated that the metric values of MNNand SHDI to have increased and the metric values of LPI has reduced during the last two decades.

  1. Graph theoretical analysis of the energy landscape of model polymers.

    Science.gov (United States)

    Baiesi, Marco; Bongini, Lorenzo; Casetti, Lapo; Tattini, Lorenzo

    2009-07-01

    In systems characterized by a rough potential-energy landscape, local energetic minima and saddles define a network of metastable states whose topology strongly influences the dynamics. Changes in temperature, causing the merging and splitting of metastable states, have nontrivial effects on such networks and must be taken into account. We do this by means of a recently proposed renormalization procedure. This method is applied to analyze the topology of the network of metastable states for different polypeptidic sequences in a minimalistic polymer model. A smaller spectral dimension emerges as a hallmark of stability of the global energy minimum and highlights a nonobvious link between dynamic and thermodynamic properties.

  2. Spectral Curve Fitting for Automatic Hyperspectral Data Analysis

    CERN Document Server

    Brown, Adrian J

    2014-01-01

    Automatic discovery and curve fitting of absorption bands in hyperspectral data can enable the analyst to identify materials present in a scene by comparison with library spectra. This procedure is common in laboratory spectra, but is challenging for sparse hyperspectral data. A procedure for robust discovery of overlapping bands in hyperspectral data is described in this paper. The method is capable of automatically discovering and fitting symmetric absorption bands, can separate overlapping absorption bands in a stable manner, and has relatively low sensitivity to noise. A comparison with techniques already available in the literature is presented using simulated spectra. An application is demonstrated utilizing the shortwave infrared (2.0-2.5 micron or 5000-4000 cm-1) region. A small hyperspectral scene is processed to demonstrate the ability of the method to detect small shifts in absorption wavelength caused by varying white mica chemistry in a natural setting.

  3. Gradient Analysis of Urbanization Pattern Based on Class-level Landscape Metrics for Shanghai Region

    Institute of Scientific and Technical Information of China (English)

    HUANG Zhen; ZHANG Li-quan; CHEN Liang

    2005-01-01

    The spatial pattern of urbanization in the Shanghai metropolitan area is quantified with GIS-based land use data set and gradient analysis of landscape metrics. A number of landscape metrics were computed along a 64 km long and 6 km wide west-east transect and another 66 km long and 6 km wide south-north transect. The results of transect analysis with class-level metrics showed that the spatial pattern of urbanization could be reliably quantified using landscape metrics with a gradient analysis approach, and the location of the urbanization center could be identified precisely and consistently with multiple indices of the landscape metrics used in this study. Different land use types exhibited distinctive, but not necessarily unique,spatial signatures that were dependent on specific landscape metrics. These results seemed to characterize the urban core of the Shanghai metropolitan area rather accurately and precisely: Agriculture patches were abundant and less fragmented; the urban land use types were extensive,having many small patches and highly fragmented.

  4. Chemical landscape analysis with the OpenTox framework.

    Science.gov (United States)

    Jeliazkova, Nina; Jeliazkov, Vedrin

    2012-01-01

    The Structure-Activity Relationships (SAR) landscape and activity cliffs concepts have their origins in medicinal chemistry and receptor-ligand interactions modelling. While intuitive, the definition of an activity cliff as a "pair of structurally similar compounds with large differences in potency" is commonly recognized as ambiguous. This paper proposes a new and efficient method for identifying activity cliffs and visualization of activity landscapes. The activity cliffs definition could be improved to reflect not the cliff steepness alone, but also the rate of the change of the steepness. The method requires explicitly setting similarity and activity difference thresholds, but provides means to explore multiple thresholds and to visualize in a single map how the thresholds affect the activity cliff identification. The identification of the activity cliffs is addressed by reformulating the problem as a statistical one, by introducing a probabilistic measure, namely, calculating the likelihood of a compound having large activity difference compared to other compounds, while being highly similar to them. The likelihood is effectively a quantification of a SAS Map with defined thresholds. Calculating the likelihood relies on four counts only, and does not require the pairwise matrix storage. This is a significant advantage, especially when processing large datasets. The method generates a list of individual compounds, ranked according to the likelihood of their involvement in the formation of activity cliffs, and goes beyond characterizing cliffs by structure pairs only. The visualisation is implemented by considering the activity plane fixed and analysing the irregularities of the similarity itself. It provides a convenient analogy to a topographic map and may help identifying the most appropriate similarity representation for each specific SAR space. The proposed method has been applied to several datasets, representing different biological activities. Finally

  5. VECTOR ANALYSIS THEORY ON LANDSCAPE PATTERN (VATLP) IN SANJIANG PLAIN MARSH,CHINA

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shu-Qing; ZHANG Jun-Yan; LI Fang

    2004-01-01

    Landscape indices are popular for the quantification of landscape pattern. But all landscape indices being used so far are scalar quantity, which measure patterns without considering sufficiently the pattern size and the directionality together. Based on planar characteristics defined in mechanics such as centroid, moment of inertia, product of inertia, principal axes and so on, vector analysis theory on landscape pattern (VATLP) is explored here. Firstly we establish a coordinate system of centroidal principal axes (CSCPA) of a patch or patches. Some related new indices including those describing the direction of pattern distribution (patch orientation (PO), vectorial patch orientation (VPO)), and those indicating the shape of patch' s equivalent ellipse ( major axis (MJA), minor axis (MIA) and eccentric rate (ER)) are deduced. These landscape metrics are then applied to the pattern analysis of Sanjiang plain marsh, the study area. Two temporal vector-based data sets of the study area come from interpretation of remote sensing images MSS (1980) and TM (2000). The application of the theory captures some shape properties of riparian wetland in Sanjiang plain marsh. The dissymmetrieal featires of Sanjiang plain marsh around principal axes due to agricultural development could also be explained.

  6. Asphericity analysis using corneal wavefront and topographic meridional fits

    Science.gov (United States)

    Arba-Mosquera, Samuel; Merayo-Lloves, Jesús; de Ortueta, Diego

    2010-03-01

    The calculation of corneal asphericity as a 3-D fit renders more accurate results when it is based on the corneal wavefront aberrations rather than on the corneal topography of the principal meridians. A more accurate prediction could be obtained for hyperopic treatments compared to myopic treatments. We evaluate a method to calculate corneal asphericity and asphericity changes after refractive surgery. Sixty eyes of 15 consecutive myopic patients and 15 consecutive hyperopic patients (n=30 each) are retrospectively evaluated. Preoperative and 3-month-postoperative topographic and corneal wavefront analyses are performed using corneal topography. Ablations are performed using a laser with an aberration-free profile. Topographic changes in asphericity and corneal aberrations are evaluated for a 6-mm corneal diameter. The induction of corneal spherical aberrations and asphericity changes correlates with the achieved defocus correction. Preoperatively as well as postoperatively, asphericity calculated from the topography meridians correlates with asphericity calculated from the corneal wavefront in myopic and hyperopic treatments. A stronger correlation between postoperative asphericity and the ideally expected/predicted asphericity is obtained based on aberration-free assumptions calculated from corneal wavefront values rather than from the meridians. In hyperopic treatments, a better correlation can be obtained compared to the correlation in myopic treatments. Corneal asphericity calculated from corneal wavefront aberrations represents a 3-D fit of the corneal surface; asphericity calculated from the main topographic meridians represents a 2-D fit of the principal corneal meridians. Postoperative corneal asphericity can be calculated from corneal wavefront aberrations with higher fidelity than from corneal topography of the principal meridians. Hyperopic treatments show a greater accuracy than myopic treatments.

  7. Spatial analysis of Lobesia botrana (Lepidoptera: Tortricidae) male population in a mediterranean agricultural landscape in central Italy.

    Science.gov (United States)

    Sciarretta, A; Zinni, A; Mazzocchetti, A; Trematerra, P

    2008-04-01

    The results obtained from the spatial analysis of pheromone-baited trap catch data of Lobesia botrana (Denis and Schiffermüller) males are reported. The research was undertaken in the Abruzzo region of central Italy. In the study area, vineyards (of Vitis vinifera L.) are the predominant cultivation, surrounded by hedgerows and small woodlots, and interspersed with cereal crops and olive groves. The main purpose of the study was to investigate the spatio-temporal dynamics of L. botrana, inside and outside vineyards, and to evaluate the effect of the landscape elements on pest distribution. A trend orientation over the experimental area was observed along the direction from northwest to southeast. Correlograms fitted using a spherical model showed in all cases an aggregated distribution and an estimated range having a mean of 174 m in 2005 and 116 m in 2006. Contour maps highlighted that spatial distribution of L. botrana was not limited to vineyards, but its presence is high particularly inside olive groves. The adult distribution on the experimental area changed during the season: hot spots of flight I were positioned inside olive groves; during flights II and III, they were concentrated in vineyards. L. botrana males were also captured in uncultivated fields, but never in high densities. Our results showed that a large proportion of the adult population of L. botrana inhabits areas outside those usually targeted by pest management programs. Thus, in Mediterranean agro-ecosystems, it is highly recommended to consider the whole landscape, with particular attention to olive crops.

  8. Pattern-based compression of multi-band image data for landscape analysis

    CERN Document Server

    Myers, Wayne L; Patil, Ganapati P

    2006-01-01

    This book describes an integrated approach to using remotely sensed data in conjunction with geographic information systems for landscape analysis. Remotely sensed data are compressed into an analytical image-map that is compatible with the most popular geographic information systems as well as freeware viewers. The approach is most effective for landscapes that exhibit a pronounced mosaic pattern of land cover. The image maps are much more compact than the original remotely sensed data, which enhances utility on the internet. As value-added products, distribution of image-maps is not affected by copyrights on original multi-band image data.

  9. A spatio-temporal analysis of landscape dynamics under changing environmental regimes in southern African savannas

    Science.gov (United States)

    Bunting, Erin L.

    The United Nations and Intergovernmental Panel on Climate Change (IPCC) deem many regions of southern Africa as vulnerable landscapes due to changing climatic regimes, ecological condition, and low adaptive capacity. The savanna ecosystems of southern Africa are of great ecological importance due to the high biodiversity they sustain, their high level of productivity, and the great role they play in the global carbon cycle. Given the dependence of humans on the lands it is essential to explore landscape level trends in patterns and processes in an effort to inform management practices. Even if climate change mitigation strategies were put in place, this is still a region heavily dependent on rain-fed agriculture and tourism of the biological diverse lands. Therefore analysis of climate variability, both interannual and intra-annual, and the changing role it plays on the landscape is critical. This body of research analyzes the role of climate variability and climate on environmental condition and socio-economic development via research on (1) spatial and temporal vegetation patterns, (2) the underlying processes that influence savanna ecosystem resilience, (3) local perception of risk to livelihood development, and (4) potential consequences of climate change on vegetation patterns. As a whole this demonstrates the key role that climate plays on savanna landscapes, which would be highly beneficial when developing conservation or mitigation strategies. Increased climate variability is occurring, but what is still open to debate is the resilience of savanna landscape and vulnerability of socio-economic development.

  10. An Integrative Platform for Three-dimensional Quantitative Analysis of Spatially Heterogeneous Metastasis Landscapes

    Science.gov (United States)

    Guldner, Ian H.; Yang, Lin; Cowdrick, Kyle R.; Wang, Qingfei; Alvarez Barrios, Wendy V.; Zellmer, Victoria R.; Zhang, Yizhe; Host, Misha; Liu, Fang; Chen, Danny Z.; Zhang, Siyuan

    2016-04-01

    Metastatic microenvironments are spatially and compositionally heterogeneous. This seemingly stochastic heterogeneity provides researchers great challenges in elucidating factors that determine metastatic outgrowth. Herein, we develop and implement an integrative platform that will enable researchers to obtain novel insights from intricate metastatic landscapes. Our two-segment platform begins with whole tissue clearing, staining, and imaging to globally delineate metastatic landscape heterogeneity with spatial and molecular resolution. The second segment of our platform applies our custom-developed SMART 3D (Spatial filtering-based background removal and Multi-chAnnel forest classifiers-based 3D ReconsTruction), a multi-faceted image analysis pipeline, permitting quantitative interrogation of functional implications of heterogeneous metastatic landscape constituents, from subcellular features to multicellular structures, within our large three-dimensional (3D) image datasets. Coupling whole tissue imaging of brain metastasis animal models with SMART 3D, we demonstrate the capability of our integrative pipeline to reveal and quantify volumetric and spatial aspects of brain metastasis landscapes, including diverse tumor morphology, heterogeneous proliferative indices, metastasis-associated astrogliosis, and vasculature spatial distribution. Collectively, our study demonstrates the utility of our novel integrative platform to reveal and quantify the global spatial and volumetric characteristics of the 3D metastatic landscape with unparalleled accuracy, opening new opportunities for unbiased investigation of novel biological phenomena in situ.

  11. A landscape-based cluster analysis using recursive search instead of a threshold parameter

    NARCIS (Netherlands)

    Gladwin, Thomas E; Vink, Matthijs; Mars, Roger B

    2016-01-01

    Cluster-based analysis methods in neuroimaging provide control of whole-brain false positive rates without the need to conservatively correct for the number of voxels and the associated false negative results. The current method defines clusters based purely on shapes in the landscape of activation,

  12. Explore the Usefulness of Person-Fit Analysis on Large-Scale Assessment

    Science.gov (United States)

    Cui, Ying; Mousavi, Amin

    2015-01-01

    The current study applied the person-fit statistic, l[subscript z], to data from a Canadian provincial achievement test to explore the usefulness of conducting person-fit analysis on large-scale assessments. Item parameter estimates were compared before and after the misfitting student responses, as identified by l[subscript z], were removed. The…

  13. Geographic information analysis: An ecological approach for the management of wildlife on the forest landscape

    Science.gov (United States)

    Ripple, William J.

    1995-01-01

    This document is a summary of the project funded by NAGw-1460 as part of the Earth Observation Commericalization/Applications Program (EOCAP) directed by NASA's Earth Science and Applications Division. The goal was to work with several agencies to focus on forest structure and landscape characterizations for wildlife habitat applications. New analysis techniques were used in remote sensing and landscape ecology with geographic information systems (GIS). The development of GIS and the emergence of the discipline of landscape ecology provided us with an opportunity to study forest and wildlife habitat resources from a new perspective. New techniques were developed to measure forest structure across scales from the canopy to the regional level. This paper describes the project team, technical advances, and technology adoption process that was used. Reprints of related refereed journal articles are in the Appendix.

  14. Panoramic UAV Views for Landscape Heritage Analysis Integrated with Historical Maps Atlases

    Directory of Open Access Journals (Sweden)

    Raffaella Brumana

    2012-12-01

    Full Text Available Analysis of landscape heritage and territorial transformations dedicated to its protection and preservation rely increasingly upon the contribution of integrated disciplines. In 2000 the European Landscape Convention established the necessity ‘to integrate landscape into its regional and town planning policies and in its cultural, environmental, agricultural, social and economic policies’. Such articulated territorial dimension requires an approach able to consider multi-dimensional data and information from different spatial and temporal series, supporting territorial analysis and spatial planning under different points of view. Most of landscape representation instruments are based on 3D models based on top-down image/views, with still weak possibilities to reproduce views similar to the human eye or map surface development along preferential directions (e.g. water front views. A methodological approach of rediscovering the long tradition of historical water front view maps, itinerary maps and human eye maps perspective, could improve content decoding of cultural heritage with environmental dimension and its knowledge transfer to planners and citizens. The research here described experiments multiple view models which can simulate real scenarios at the height of observer or along view front. The paper investigates the possibilities of panoramic views simulation and reconstruction from images acquired by RC/UAV platforms and multisensory systems, testing orthoimage generation for landscape riparian areas and water front wiew representation, verifying the application of automatic algorithms for image orientation and DTM extraction (AtiPE, ATE on such complex image models, identifying critical aspects for future development. The sample landscape portion along ancient water corridor, with stratified values of anthropogenic environment, shows the potentials of future achievement in supporting sustainable planning through technical water front

  15. The marketing analysis of competitiveness of fitness-clubs in Kharkiv

    Directory of Open Access Journals (Sweden)

    Svitlana Stadnyk

    2016-12-01

    Full Text Available Purpose: to carry out the marketing analysis of competitiveness of fitness-clubs of Kharkiv. Material & Methods: analysis of references and documents, organizational analysis, system analysis, methods of the marketing analysis (SWOT-analysis, methods of mathematical data processing. The research was conducted on the basis of 13 fitness-clubs of Kharkiv. Administrators acted as respondents – 15 persons; those who are engaged in fitness-clubs – 50 persons. Results: opportunities and threats of the external environment of fitness-clubs of Kharkiv are defined on the basis of the carried-out marketing analysis, satisfaction of Kharkov citizens with activity of fitness-clubs of the city from providing recreational services is found. Conclusions: the carried-out analysis of marketing activity of fitness-clubs of Kharkiv gave the chance to find possible threats from competitors: the rate of inflation in the country, the appearance of new competitors, the change of level of the income of the population, the increase in mortality of the population, the change of attachments of the population.

  16. Embodied language, best-fit analysis, and formal compositionality

    Science.gov (United States)

    Feldman, Jerome

    2010-12-01

    This review brings together two fundamental, but unreconciled, aspects of human language: embodiment and compositionality. One major scientific advance in recent decades has been Embodiment - the realization that scientific understanding of mind and language entails detailed modeling of the human brain and how it evolved to control a physical body in a social community. The ability to learn and use language is one of the most characteristically human traits. Many animals signal, but only people can express and understand an essentially unbounded range of messages. The technical term for the ability of human language to support all these messages from a few dozen alphabetic symbols is Compositionality. Rigor is essential for the advancement of any science, but there has been essentially no overlap between efforts to formalize language compositionality and the manifest embodiment of thought. Recent developments suggest that it is feasible to formalize the compositionality of embodied language, but that this requires a focus on conceptual composition and better understanding of contextual best-fit.

  17. Embodied language, best-fit analysis, and formal compositionality.

    Science.gov (United States)

    Feldman, Jerome

    2010-12-01

    This review brings together two fundamental, but unreconciled, aspects of human language: embodiment and compositionality. One major scientific advance in recent decades has been Embodiment - the realization that scientific understanding of mind and language entails detailed modeling of the human brain and how it evolved to control a physical body in a social community. The ability to learn and use language is one of the most characteristically human traits. Many animals signal, but only people can express and understand an essentially unbounded range of messages. The technical term for the ability of human language to support all these messages from a few dozen alphabetic symbols is Compositionality. Rigor is essential for the advancement of any science, but there has been essentially no overlap between efforts to formalize language compositionality and the manifest embodiment of thought. Recent developments suggest that it is feasible to formalize the compositionality of embodied language, but that this requires a focus on conceptual composition and better understanding of contextual best-fit.

  18. QUANTITATIVE ANALYSIS AND FRACTAL MODELING ON THE MOSAIC STRUCTURE OF LANDSCAPE IN THE CENTRAL AREA OF SHANGHAI METROPOLIS

    Institute of Scientific and Technical Information of China (English)

    XU Jian-hua; AI Nan-shan; CHEN Yong; MEI An-xin; LIAO Hong-juan

    2003-01-01

    The mosaic structure of landscape of the central area of Shanghai Metropolis is studied by quantitative methods of landscape ecology based on Remote Sensing (RS) and Geographic Information System (GIS) in this pa-per. Firstly, landscapes are classified into eight categories: residential quarter, industrial quarter, road, other urban landscape, farmland, village and small town, on-building area, river and other water bodies (such as lake, etc.). Sec-ondly, a GIS is designed and set up based on the remote sensing data and field investigation, and a digital map of landscape mosaic is made. Then the indexes of diversity, dominance, fragmentation and isolation, and fractal dimen-sion of each type of landscape in different periods are calculated by using spatial analysis method of GIS. With refer-ence to the calculated results, a series of relative issues are discussed.

  19. Chemical Engineering Data Analysis Made Easy with DataFit

    Science.gov (United States)

    Brenner, James R.

    2006-01-01

    The outline for half of a one-credit-hour course in analysis of chemical engineering data is presented, along with a range of typical problems encountered later on in the chemical engineering curriculum that can be used to reinforce the data analysis skills learned in the course. This mini course allows students to be exposed to a variety of ChE…

  20. Contrasting cascade effects of carnivores on plant fitness: a meta-analysis.

    Science.gov (United States)

    Romero, Gustavo Q; Koricheva, Julia

    2011-05-01

    1. Although carnivores indirectly improve plant fitness by decreasing herbivory, they may also decrease plant reproduction by disrupting plant-pollinator mutualism. The overall magnitude of the resulting net effect of carnivores on plant fitness and the factors responsible for the variations in strength and direction of this effect have not been explored quantitatively to date. 2. We performed a meta-analysis of 67 studies containing 163 estimates of the effects of carnivores on plant fitness and examined the relative importance of several potential sources of variation in carnivore effects. 3. Carnivores significantly increased plant fitness via suppression of herbivores and decreased fitness by consuming pollinators. The overall net effect of carnivores on plant fitness was positive (32% increase), indicating that effects via herbivores were stronger than effects via pollinators. 4. Parasitoids had stronger positive effect on plant fitness than predators. Active hunters increased plant fitness, whereas stationary predators had no significant effect, presumably because they were more prone to disrupt plant-pollinator mutualism. Carnivores with broader habitat domain had negative effects on plant fitness, whereas those with narrow habitat domain had positive effects. 5. Predator effects were positive for plants which offered rewards (e.g. extrafloral nectaries) and negative for plants which lacked any attractors. 6. This study adds new knowledge on the factors that determine the strength of terrestrial trophic cascades and highlights the importance of considering simultaneous contrasting interactions in the same study system. © 2011 The Authors. Journal of Animal Ecology © 2011 British Ecological Society.

  1. Nonlinear Fitting Method of Long-Term Distributions for Statistical Analysis of Extreme Negative Surge Elevations

    Institute of Scientific and Technical Information of China (English)

    DONG Sheng; LI Fengli; JIAO Guiying

    2003-01-01

    Hydrologic frequency analysis plays an important role in coastal and ocean engineering for structural design and disaster prevention in coastal areas. This paper proposes a Nonlinear Least Squares Method (NLSM), which estimates the three unknown parameters of the Weibull distribution simultaneously by an iteration method. Statistical test shows that the NLSM fits each data sample well. The effects of different parameter-fitting methods, distribution models, and threshold values are also discussed in the statistical analysis of storm set-down elevation. The best-fitting probability distribution is given and the corresponding return values are estimated for engineering design.

  2. Analysis of Dynamics of Forest Landscapes of Administrative District by Means of GIS Technologies

    Directory of Open Access Journals (Sweden)

    Teslenok S.A.

    2015-12-01

    Full Text Available On the example of the territory of Insarsky District, located in the South of the middle part of the Republic of Mordovia, the authors reviewed the methodology and presented the results of the use of geographic information and aerospace technologies for the analysis of the dynamics of forest landscape in the period between the time slices – 1941 and 2009. The research allowed to reveal tendencies of change and development of forest landscapes through the creation of specialized GIS databases and the use of software ArcView GIS, MapInfo Professional, SAS.Planet, ERDAS Imagine, EasyTrace. Baseline data were presented cartographic materials – retrospective traditional and digital as well as the actual remote sensing data. Determining the area of forest landscapes, analysis, comparison, display and cartographic visualization of their dynamics are based on cartographicmaterials produced using GIS technology. In the GIS have been produced covered (overlay vector layers, analysis and comparison of obtained maps identifying the direction (increase or decrease of the changes and their possible causes, in order to reveal the dynamics the area of forest landscapes. In the case of processing of raster cartographic materials you can use toolkit raster algebra (map algebra. As a result, have been identified direction and possible causes of the changes the area of forest geosystems for each of the studied time sections, as well as the quantitative characteristics of extant disappeared and re-emerged of their arrays. In most of the analyzed territory there was an increase of forest landscapes, the cause of which should be considered as abandonment and non-use of agricultural land. The slight decrease in the area of forest geosystems may be associated with deforestation and fires. Obtained through research geoinformation and cartographic models and statistics are the basis for management decisions in the field of forestry and forest management, organization

  3. GPUs for statistical data analysis in HEP: a performance study of GooFit on GPUs vs. RooFit on CPUs

    Science.gov (United States)

    Pompili, Alexis; Di Florio, Adriano; CMS Collaboration

    2016-10-01

    In order to test the computing capabilities of GPUs with respect to traditional CPU cores a high-statistics toy Monte Carlo technique has been implemented both in ROOT/RooFit and GooFit frameworks with the purpose to estimate the statistical significance of the structure observed by CMS close to the kinematical boundary of the Jψϕ invariant mass in the three-body decay B +→JψϕK +. GooFit is a data analysis open tool under development that interfaces ROOT/RooFit to CUDA platform on nVidia GPU. The optimized GooFit application running on GPUs hosted by servers in the Bari Tier2 provides striking speed-up performances with respect to the RooFit application parallelised on multiple CPUs by means of PROOF-Lite tool. The considerably resulting speed-up, while comparing concurrent GooFit processes allowed by CUDA Multi Process Service and a RooFit/PROOF-Lite process with multiple CPU workers, is presented and discussed in detail. By means of GooFit it has also been possible to explore the behaviour of a likelihood ratio test statistic in different situations in which the Wilks Theorem may apply or does not apply because its regularity conditions are not satisfied.

  4. GPU-accelerated analysis and visualization of large structures solved by molecular dynamics flexible fitting.

    Science.gov (United States)

    Stone, John E; McGreevy, Ryan; Isralewitz, Barry; Schulten, Klaus

    2014-01-01

    Hybrid structure fitting methods combine data from cryo-electron microscopy and X-ray crystallography with molecular dynamics simulations for the determination of all-atom structures of large biomolecular complexes. Evaluating the quality-of-fit obtained from hybrid fitting is computationally demanding, particularly in the context of a multiplicity of structural conformations that must be evaluated. Existing tools for quality-of-fit analysis and visualization have previously targeted small structures and are too slow to be used interactively for large biomolecular complexes of particular interest today such as viruses or for long molecular dynamics trajectories as they arise in protein folding. We present new data-parallel and GPU-accelerated algorithms for rapid interactive computation of quality-of-fit metrics linking all-atom structures and molecular dynamics trajectories to experimentally-determined density maps obtained from cryo-electron microscopy or X-ray crystallography. We evaluate the performance and accuracy of the new quality-of-fit analysis algorithms vis-à-vis existing tools, examine algorithm performance on GPU-accelerated desktop workstations and supercomputers, and describe new visualization techniques for results of hybrid structure fitting methods.

  5. Rich RNA Structure Landscapes Revealed by Mutate-and-Map Analysis.

    Directory of Open Access Journals (Sweden)

    Pablo Cordero

    2015-11-01

    Full Text Available Landscapes exhibiting multiple secondary structures arise in natural RNA molecules that modulate gene expression, protein synthesis, and viral infection [corrected]. We report herein that high-throughput chemical experiments can isolate an RNA's multiple alternative secondary structures as they are stabilized by systematic mutagenesis (mutate-and-map, M2 and that a computational algorithm, REEFFIT, enables unbiased reconstruction of these states' structures and populations. In an in silico benchmark on non-coding RNAs with complex landscapes, M2-REEFFIT recovers 95% of RNA helices present with at least 25% population while maintaining a low false discovery rate (10% and conservative error estimates. In experimental benchmarks, M2-REEFFIT recovers the structure landscapes of a 35-nt MedLoop hairpin, a 110-nt 16S rRNA four-way junction with an excited state, a 25-nt bistable hairpin, and a 112-nt three-state adenine riboswitch with its expression platform, molecules whose characterization previously required expert mutational analysis and specialized NMR or chemical mapping experiments. With this validation, M2-REEFFIT enabled tests of whether artificial RNA sequences might exhibit complex landscapes in the absence of explicit design. An artificial flavin mononucleotide riboswitch and a randomly generated RNA sequence are found to interconvert between three or more states, including structures for which there was no design, but that could be stabilized through mutations. These results highlight the likely pervasiveness of rich landscapes with multiple secondary structures in both natural and artificial RNAs and demonstrate an automated chemical/computational route for their empirical characterization.

  6. Repeated holdout Cross-Validation of Model to Estimate Risk of Lyme Disease by Landscape Attributes

    Science.gov (United States)

    We previously modeled Lyme disease (LD) risk at the landscape scale; here we evaluate the model's overall goodness-of-fit using holdout validation. Landscapes were characterized within road-bounded analysis units (AU). Observed LD cases (obsLD) were ascertained per AU. Data were ...

  7. PREdator: a python based GUI for data analysis, evaluation and fitting

    Science.gov (United States)

    2014-01-01

    The analysis of a series of experimental data is an essential procedure in virtually every field of research. The information contained in the data is extracted by fitting the experimental data to a mathematical model. The type of the mathematical model (linear, exponential, logarithmic, etc.) reflects the physical laws that underlie the experimental data. Here, we aim to provide a readily accessible, user-friendly python script for data analysis, evaluation and fitting. PREdator is presented at the example of NMR paramagnetic relaxation enhancement analysis.

  8. An Exploratory Factor Analysis Examining Traits, Perceived Fit and Job Satisfaction in Employed College Graduates

    Science.gov (United States)

    Brandon, John R.

    2011-01-01

    This study is an analysis of 24 variables associated with employee attitudes, behaviors and outcomes. A total of 140 college graduates participated in the study. Utilizing exploratory factor analysis (EFA) techniques, the research examined relationships among the following variables: perceived fit, job satisfaction, cognitive ability, vocational…

  9. Multitemporal analysis of landscape metrics for monitoring forested patterns in coastal and mountainous areas

    Science.gov (United States)

    Carone, M. T.; Imbrenda, V.; Lanfredi, M.; Macchiato, M.; Simoniello, T.

    2009-04-01

    series of Landsat-TM subscenes: for area A, we used five images covering the period 1987-2006; and for area B, three images covering the period 1993-1998. The analysis of landscape structure and dynamics were performed by elaborating metrics based on patch number, size, shape and arrangements of different land cover types. At landscape level, area A provided quite low levels of Evenness (SHEIforests in the period 1987-1998 when they show an alternation with a less structured and herbaceous vegetation. For area B, the landscape level shows, in the studied period, stable high values of Evenness (SHEI>0.80) and medium values of Diversity (SHDI~1.8). Metrics for patch and class levels reveal, instead, an increment in size and complexity for anthropical vegetation and a decrement for natural forested areas (mainly beeches) accompanied by a high variability of the transitional areas located along the edges of forested sites. On the whole, the combined interpretation of metrics at different levels of landscape structure and at different time steps revealed an increasing trend of forest isolation and fragmentation, which can enhance their sensitivity. The obtained results for both areas suggest that the institution of protected areas is not a complete solution for the maintaining of forest ecosystems balance without a correct management of the surrounding areas. In order to increase the connectivity among forested patches and, more in general, to improve the ecosystem functionality, the ecological analysis of satellite time series represents an operative tool for an efficient intervention planning, such as the location of the most suitable sites for ecological restoration activities.

  10. SPATIAL GRADIENT ANALYSIS OF URBAN GREEN SPACES COMBINED WITH LANDSCAPE METRICS IN JINAN CITY OF CHINA

    Institute of Scientific and Technical Information of China (English)

    KONG Fan-hua; Nobukazu NAKAGOSHI; YIN Hai-wei; Akira KIKUCHI

    2005-01-01

    Urban green spaces have been arisen growing concern responded to the social and environmental costs of urban sprawl. A wide range of planning and policies has been and/or will be designed to protect urban green spaces and optimize their spatial pattern. A better design or planning of urban green space can make a major contribution to quality of environment and urban life, and furthermore can decide whether we can have a sustainable development in the urban area. Information about the status quo of urban green spaces can help planners design more effectively.However, how to quantify and capture such information will be the essential question we face. In this paper, to quantify the urban green space, a new method comprising gradient analysis, landscape metrics and GIS was developed through a case of Jinan City. The results demonstrate: 1) the gradient analysis is a valid and reliable instrument to quantify the urban green space spatial pattern precisely; 2) using moving window, explicit landscape metrics were spatially realized. Compared with quantifying metrics in the entire landscape, it would be better to link pattern with process and establish an important basis for analyzing the ecological and socioeconomic functions of green spaces.

  11. Landscape level analysis of disturbance regimes in protected areas of Rajasthan, India

    Indian Academy of Sciences (India)

    P Hari Krishna; C Sudhakar Reddy; Randeep Singh; C S Jha

    2014-04-01

    There is an urgent need to identify the human influence on landscape as disturbance regimes was realized for prioritization of the protected areas. The present study has attempted to describe the landscape level assessment of fragmentation and disturbance index in protected areas of Rajasthan using remote sensing and GIS techniques. Geospatial analysis of disturbance regimes indicates 61.75% of the total Pas are under moderate disturbance index followed by 28.64% and 9.61% under low and high, respectively. Among the 28 protected areas – National Chambal WLS, Jaisamand WLS, Kumbhalgarh WLS, Sawai Man Singh WLS, Kailadevi WLS and Bandh BarathaWLS are representing high level of disturbance. The present study has emphasized the moderate to low disturbance regimes in protected areas, which infer low biotic pressure and conservation effectiveness of PA network in Rajasthan. The spatial information generated on PAs is of valuable use for forest management and developing conservation strategies.

  12. An Experimental Analysis of Water and Soil Conservation Effected by Micro-landscape Structure

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    [Objective] This comparative experiment was to explore the soil loss con- trol effects under cultivation combination of different soil and vegetation types, and to provide scientific basis for the upcoming pilot project of ecological recovery. [Method] Both the rudiment of water locomotion functioned by micro-landscape structures and different spatial combinations of various landscape constituents are considered, thus, the combination of multi-soil type, crop species and site conditions is designed in three different experimental sites. [Result] Soil loss estimates in experiments in South Wello significantly depended on various soil type, slope, vegetation and type of con- servation structure; grass cover tremendously reduces soil loss; legume cultivation performed better than cereal cultivation in soil loss control. [Conclusion] By conduct- ing the data analysis of the experiment, a scientific reference is proposed to the agri- culture planting and protective mode for the alleviation of water and soil loss in Amhara Region, Ethiopia.

  13. Accounting for Calibration Uncertainties in X-ray Analysis: Effective Areas in Spectral Fitting

    CERN Document Server

    Lee, Hyunsook; van Dyk, David A; Connors, Alanna; Drake, Jeremy J; Izem, Rima; Meng, Xiao-Li; Min, Shandong; Park, Taeyoung; Ratzlaff, Pete; Siemiginowska, Aneta; Zezas, Andreas

    2011-01-01

    While considerable advance has been made to account for statistical uncertainties in astronomical analyses, systematic instrumental uncertainties have been generally ignored. This can be crucial to a proper interpretation of analysis results because instrumental calibration uncertainty is a form of systematic uncertainty. Ignoring it can underestimate error bars and introduce bias into the fitted values of model parameters. Accounting for such uncertainties currently requires extensive case-specific simulations if using existing analysis packages. Here we present general statistical methods that incorporate calibration uncertainties into spectral analysis of high-energy data. We first present a method based on multiple imputation that can be applied with any fitting method, but is necessarily approximate. We then describe a more exact Bayesian approach that works in conjunction with a Markov chain Monte Carlo based fitting. We explore methods for improving computational efficiency, and in particular detail a ...

  14. Lines of landscape organisation

    DEFF Research Database (Denmark)

    Løvschal, Mette

    2015-01-01

    This paper offers a landscape analysis of the earliest linear landscape boundaries on Skovbjerg Moraine, Denmark, during the first millennium BC. Using Delaunay triangulation as well as classic distribution analyses, it demonstrates that landscape boundaries articulated already established use-pa...

  15. Complexity of free energy landscapes of peptides revealed by nonlinear principal component analysis.

    Science.gov (United States)

    Nguyen, Phuong H

    2006-12-01

    Employing the recently developed hierarchical nonlinear principal component analysis (NLPCA) method of Saegusa et al. (Neurocomputing 2004;61:57-70 and IEICE Trans Inf Syst 2005;E88-D:2242-2248), the complexities of the free energy landscapes of several peptides, including triglycine, hexaalanine, and the C-terminal beta-hairpin of protein G, were studied. First, the performance of this NLPCA method was compared with the standard linear principal component analysis (PCA). In particular, we compared two methods according to (1) the ability of the dimensionality reduction and (2) the efficient representation of peptide conformations in low-dimensional spaces spanned by the first few principal components. The study revealed that NLPCA reduces the dimensionality of the considered systems much better, than did PCA. For example, in order to get the similar error, which is due to representation of the original data of beta-hairpin in low dimensional space, one needs 4 and 21 principal components of NLPCA and PCA, respectively. Second, by representing the free energy landscapes of the considered systems as a function of the first two principal components obtained from PCA, we obtained the relatively well-structured free energy landscapes. In contrast, the free energy landscapes of NLPCA are much more complicated, exhibiting many states which are hidden in the PCA maps, especially in the unfolded regions. Furthermore, the study also showed that many states in the PCA maps are mixed up by several peptide conformations, while those of the NLPCA maps are more pure. This finding suggests that the NLPCA should be used to capture the essential features of the systems.

  16. Changing Landscape

    DEFF Research Database (Denmark)

    Tunby Gulbrandsen, Ib; Kamstrup, Andreas; Koed Madsen, Anders

    with an analysis of the changing organizational landscape created by new ICT’s like Google, Facebook, Wikipedia, iPods, smart phones and Wi-Fi. Based on five netno- and ethno-graphic investigations of the intertwinement of ICT’s and organizational work, we point to three features that have changed the scene: new...

  17. Changing Landscape

    DEFF Research Database (Denmark)

    Tunby Gulbrandsen, Ib; Kamstrup, Andreas; Koed Madsen, Anders

    with an analysis of the changing organizational landscape created by new ICT’s like Google, Facebook, Wikipedia, iPods, smart phones and Wi-Fi. Based on five netno- and ethno-graphic investigations of the intertwinement of ICT’s and organizational work, we point to three features that have changed the scene: new...

  18. Advanced alpha spectrum analysis based on the fitting and covariance analysis of dependent variables

    Science.gov (United States)

    Ihantola, S.; Pelikan, A.; Pöllänen, R.; Toivonen, H.

    2011-11-01

    The correct handling of statistical uncertainties is crucial especially when unfolding alpha spectra that contain a low number of counts or overlapping peaks from different nuclides. For this purpose, we have developed a new spectrum analysis software package called ADAM, which performs a full covariance calculus for alpha-particle emitting radionuclides. By analyzing a large number of simulated and measured spectra, the program was proved to give unbiased peak areas and statistically correct uncertainty limits. This applies regardless of the peak areas and the number of unknown parameters during the fitting. In addition, ADAM performs reliable deconvolution for multiplets, which opens the way for the determination of isotope ratios, such as 239Pu/240Pu.

  19. Intrinsically Disordered Energy Landscapes

    Science.gov (United States)

    Chebaro, Yassmine; Ballard, Andrew J.; Chakraborty, Debayan; Wales, David J.

    2015-05-01

    Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such ‘intrinsically disordered’ landscapes, with a number of very different competing low-energy structures, are likely to characterise IDPs, and provide a useful way to address their properties. In particular, IDPs are present in many cellular protein interaction networks, and several questions arise regarding how they bind to partners. Are conformations resembling the bound structure selected for binding, or does further folding occur on binding the partner in a induced-fit fashion? We focus on the p53 upregulated modulator of apoptosis (PUMA) protein, which adopts an -helical conformation when bound to its partner, and is involved in the activation of apoptosis. Recent experimental evidence shows that folding is not necessary for binding, and supports an induced-fit mechanism. Using a variety of computational approaches we deduce the molecular mechanism behind the instability of the PUMA peptide as a helix in isolation. We find significant barriers between partially folded states and the helix. Our results show that the favoured conformations are molten-globule like, stabilised by charged and hydrophobic contacts, with structures resembling the bound state relatively unpopulated in equilibrium.

  20. Landscape dynamics analysis in Iasi Metropolitan Area (Romania using remote sensing data

    Directory of Open Access Journals (Sweden)

    CÃTÃLIN CÎMPIANU

    2013-08-01

    Full Text Available The present paper focuses on the observation and quantification of land cover changes in Iasi Metropolitan Area during 1993-2009. The analysis is centered upon the built-up space dynamics and includes the detection of its extension directions and the measurement of its structural changes by landscape metrics. In order to obtain the land cover data, some remote sensing images were processed by supervised classification and Normalized Difference Vegetation Index (NDVI. In the end of the study, a synthetic statistical analysis of the change dynamics is performed at commune level, in order to compare the administrative units by the intensity of land cover dynamics.

  1. Transition Path Times for Nucleic Acid Folding Determined from Energy-Landscape Analysis of Single-Molecule Trajectories

    Science.gov (United States)

    Neupane, Krishna; Ritchie, Dustin B.; Yu, Hao; Foster, Daniel A. N.; Wang, Feng; Woodside, Michael T.

    2012-08-01

    The duration of structural transitions in biopolymers is only a fraction of the time spent searching diffusively over the configurational energy landscape. We found the transition time, τTP, and the diffusion constant, D, for DNA and RNA folding using energy landscapes obtained from single-molecule trajectories under tension in optical traps. DNA hairpins, RNA pseudoknots, and a riboswitch all had τTP˜10μs and D˜10-13-14m2/s, despite widely differing unfolding rates. These results show how energy-landscape analysis can be harnessed to characterize brief but critical events during folding reactions.

  2. Visualizing nD Point Clouds as Topological Landscape Profiles to Guide Local Data Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Oesterling, Patrick [Univ. of Leipzig (Germany). Computer Science Dept.; Heine, Christian [Univ. of Leipzig (Germany). Computer Science Dept.; Federal Inst. of Technology (ETH), Zurich (Switzerland). Dept. of Computer Science; Weber, Gunther H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Scheuermann, Gerik [Univ. of Leipzig (Germany). Computer Science Dept.

    2012-05-04

    Analyzing high-dimensional point clouds is a classical challenge in visual analytics. Traditional techniques, such as projections or axis-based techniques, suffer from projection artifacts, occlusion, and visual complexity.We propose to split data analysis into two parts to address these shortcomings. First, a structural overview phase abstracts data by its density distribution. This phase performs topological analysis to support accurate and non-overlapping presentation of the high-dimensional cluster structure as a topological landscape profile. Utilizing a landscape metaphor, it presents clusters and their nesting as hills whose height, width, and shape reflect cluster coherence, size, and stability, respectively. A second local analysis phase utilizes this global structural knowledge to select individual clusters or point sets for further, localized data analysis. Focusing on structural entities significantly reduces visual clutter in established geometric visualizations and permits a clearer, more thorough data analysis. In conclusion, this analysis complements the global topological perspective and enables the user to study subspaces or geometric properties, such as shape.

  3. Visualizing nD point clouds as topological landscape profiles to guide local data analysis.

    Science.gov (United States)

    Oesterling, Patrick; Heine, Christian; Weber, Gunther H; Scheuermann, Gerik

    2013-03-01

    Analyzing high-dimensional point clouds is a classical challenge in visual analytics. Traditional techniques, such as projections or axis-based techniques, suffer from projection artifacts, occlusion, and visual complexity. We propose to split data analysis into two parts to address these shortcomings. First, a structural overview phase abstracts data by its density distribution. This phase performs topological analysis to support accurate and nonoverlapping presentation of the high-dimensional cluster structure as a topological landscape profile. Utilizing a landscape metaphor, it presents clusters and their nesting as hills whose height, width, and shape reflect cluster coherence, size, and stability, respectively. A second local analysis phase utilizes this global structural knowledge to select individual clusters or point sets for further, localized data analysis. Focusing on structural entities significantly reduces visual clutter in established geometric visualizations and permits a clearer, more thorough data analysis. This analysis complements the global topological perspective and enables the user to study subspaces or geometric properties, such as shape.

  4. Adding Graphical Interactive FITS Image Interaction to Data Analysis in IPython Notebooks

    Science.gov (United States)

    Jeschke, E.

    2014-05-01

    IPython notebooks are becoming a popular and viable approach for documenting data analysis procedures and helping produce open, reproducible science. Recent developments in the IPython project allow notebooks to be published and viewed on the web, providing a nearly seamless transition from data analysis to publication. In this talk we will review and demonstrate the ipython notebook as a data analysis tool, and show how graphical FITS image interaction can be integrated in the workflow to simplify some cumbersome tasks.

  5. Landscape analysis of urban growth patterns in Seremban, Malaysia, using spatio-temporal data

    Science.gov (United States)

    Aburas, Maher M.; Abdullah, Sabrina H.; Ramli, Mohammad F.; As'shari, Zulfa H.

    2016-06-01

    Urban growth is one of the major issues that have played a significant role in destroying the ecosystem in recent years. Landscape analysis is an important technique widely used to evaluate urban growth patterns. In this study, four land-use maps from 1984, 1990, 2000, and 2010 have been used to analyze an urban landscape. The values of a built-up area were initially computed using a geographic information system environment based on the spatial gradient approach. Mathematical matrices were then used to determine the amount of change in urban patches in each direction. Results of the number of patches, landscape shape index, aggregation index, and total edges confirmed that the urban patches in Seremban, Malaysia, have become more dispersed from 2000 to 2010. The urban patches have also become more continuous, especially in the north-western part of Seremban as a result of the urban development in the Nilai District. These results indicate the necessity to create new policies in the city to protect the sustainability of the land use of Seremban.

  6. Alternative future analysis for assessing the potential impact of climate change on urban landscape dynamics.

    Science.gov (United States)

    He, Chunyang; Zhao, Yuanyuan; Huang, Qingxu; Zhang, Qiaofeng; Zhang, Da

    2015-11-01

    Assessing the impact of climate change on urban landscape dynamics (ULD) is the foundation for adapting to climate change and maintaining urban landscape sustainability. This paper demonstrates an alternative future analysis by coupling a system dynamics (SD) and a cellular automata (CA) model. The potential impact of different climate change scenarios on ULD from 2009 to 2030 was simulated and evaluated in the Beijing-Tianjin-Tangshan megalopolis cluster area (BTT-MCA). The results suggested that the integrated model, which combines the advantages of the SD and CA model, has the strengths of spatial quantification and flexibility. Meanwhile, the results showed that the influence of climate change would become more severe over time. In 2030, the potential urban area affected by climate change will be 343.60-1260.66 km(2) (5.55 -20.37 % of the total urban area, projected by the no-climate-change-effect scenario). Therefore, the effects of climate change should not be neglected when designing and managing urban landscape.

  7. Assessing the Goodness of Fit of Phylogenetic Comparative Methods: A Meta-Analysis and Simulation Study.

    Science.gov (United States)

    Jhwueng, Dwueng-Chwuan

    2013-01-01

    Phylogenetic comparative methods (PCMs) have been applied widely in analyzing data from related species but their fit to data is rarely assessed. Can one determine whether any particular comparative method is typically more appropriate than others by examining comparative data sets? I conducted a meta-analysis of 122 phylogenetic data sets found by searching all papers in JEB, Blackwell Synergy and JSTOR published in 2002-2005 for the purpose of assessing the fit of PCMs. The number of species in these data sets ranged from 9 to 117. I used the Akaike information criterion to compare PCMs, and then fit PCMs to bivariate data sets through REML analysis. Correlation estimates between two traits and bootstrapped confidence intervals of correlations from each model were also compared. For phylogenies of less than one hundred taxa, the Independent Contrast method and the independent, non-phylogenetic models provide the best fit.For bivariate analysis, correlations from different PCMs are qualitatively similar so that actual correlations from real data seem to be robust to the PCM chosen for the analysis. Therefore, researchers might apply the PCM they believe best describes the evolutionary mechanisms underlying their data.

  8. Assessing the Goodness of Fit of Phylogenetic Comparative Methods: A Meta-Analysis and Simulation Study.

    Directory of Open Access Journals (Sweden)

    Dwueng-Chwuan Jhwueng

    Full Text Available Phylogenetic comparative methods (PCMs have been applied widely in analyzing data from related species but their fit to data is rarely assessed.Can one determine whether any particular comparative method is typically more appropriate than others by examining comparative data sets?I conducted a meta-analysis of 122 phylogenetic data sets found by searching all papers in JEB, Blackwell Synergy and JSTOR published in 2002-2005 for the purpose of assessing the fit of PCMs. The number of species in these data sets ranged from 9 to 117.I used the Akaike information criterion to compare PCMs, and then fit PCMs to bivariate data sets through REML analysis. Correlation estimates between two traits and bootstrapped confidence intervals of correlations from each model were also compared.For phylogenies of less than one hundred taxa, the Independent Contrast method and the independent, non-phylogenetic models provide the best fit.For bivariate analysis, correlations from different PCMs are qualitatively similar so that actual correlations from real data seem to be robust to the PCM chosen for the analysis. Therefore, researchers might apply the PCM they believe best describes the evolutionary mechanisms underlying their data.

  9. The Effect of Missing Data Handling Methods on Goodness of Fit Indices in Confirmatory Factor Analysis

    Science.gov (United States)

    Köse, Alper

    2014-01-01

    The primary objective of this study was to examine the effect of missing data on goodness of fit statistics in confirmatory factor analysis (CFA). For this aim, four missing data handling methods; listwise deletion, full information maximum likelihood, regression imputation and expectation maximization (EM) imputation were examined in terms of…

  10. Fitness levels with tail bounds for the analysis of randomized search heuristics

    DEFF Research Database (Denmark)

    Witt, Carsten

    2014-01-01

    The fitness-level method, also called the method of f-based partitions, is an intuitive and widely used technique for the running time analysis of randomized search heuristics. It was originally defined to prove upper and lower bounds on the expected running time. Recently, upper tail bounds were...... added to the technique; however, these tail bounds only apply to running times that are at least twice as large as the expectation.We remove this restriction and supplement the fitness-level method with sharp tail bounds, including lower tails. As an exemplary application, we prove that the running time...

  11. A multiscale analysis of gene flow for the New England cottontail, an imperiled habitat specialist in a fragmented landscape.

    Science.gov (United States)

    Fenderson, Lindsey E; Kovach, Adrienne I; Litvaitis, John A; O'Brien, Kathleen M; Boland, Kelly M; Jakubas, Walter J

    2014-05-01

    Landscape features of anthropogenic or natural origin can influence organisms' dispersal patterns and the connectivity of populations. Understanding these relationships is of broad interest in ecology and evolutionary biology and provides key insights for habitat conservation planning at the landscape scale. This knowledge is germane to restoration efforts for the New England cottontail (Sylvilagus transitionalis), an early successional habitat specialist of conservation concern. We evaluated local population structure and measures of genetic diversity of a geographically isolated population of cottontails in the northeastern United States. We also conducted a multiscale landscape genetic analysis, in which we assessed genetic discontinuities relative to the landscape and developed several resistance models to test hypotheses about landscape features that promote or inhibit cottontail dispersal within and across the local populations. Bayesian clustering identified four genetically distinct populations, with very little migration among them, and additional substructure within one of those populations. These populations had private alleles, low genetic diversity, critically low effective population sizes (3.2-36.7), and evidence of recent genetic bottlenecks. Major highways and a river were found to limit cottontail dispersal and to separate populations. The habitat along roadsides, railroad beds, and utility corridors, on the other hand, was found to facilitate cottontail movement among patches. The relative importance of dispersal barriers and facilitators on gene flow varied among populations in relation to landscape composition, demonstrating the complexity and context dependency of factors influencing gene flow and highlighting the importance of replication and scale in landscape genetic studies. Our findings provide information for the design of restoration landscapes for the New England cottontail and also highlight the dual influence of roads, as both

  12. Comparison of an analog and digital quantitative and qualitative analysis for the fit of dental copings.

    Science.gov (United States)

    Kuhn, Katharina; Ostertag, Silke; Ostertag, Michael; Walter, Michael H; Luthardt, Ralph G; Rudolph, Heike

    2015-02-01

    Precision in fit is crucial for dental crowns and bridges. Most analyses of fit are based on analog 2D techniques. Aim of this in-vitro study was to compare an analog and a digital quantitative and qualitative analysis for the fit of CAD/CAM fabricated dental copings. A prepared steel canine served as master die. CAD surface models, varying in data density, were purposely enlarged in height (Ez), circumference (Exy) and both of these aspects at once (Exyz). Two titanium copings for each variation were produced. The silicone-replica-technique was applied to analyze the fit by means of a 2D analog light microscope measurement (LMM) and a 3D computer-assisted measurement using an optical digitizing system (ODKM97), respectively. In most cases, restorations based on the low data density showed a better fit than those based on high data density. Original size low density data showed the lowest marginal and axial values in the quantitative 2D analyses (LMM and ODKM97). The 3D measurements (ODKM97) revealed best fit of the low density original size specimens, whereas the Ez specimens showed the highest values. Noticeable variations in fit were detected marginally and axially depending on the specific measurement point (mesial, distal, oral, or buccal) for both measurement systems. The analog 2D replica technique revealed a loss of information due to the necessary cutting process. By contrast, the digital computer-based method provided 3D quantitative and qualitative results without data loss over the complete surface. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. XRD fitting analysis of semiconductor heterostructures [Puolijohderakenteiden r\\"ontgendiffraktion sovitusanalyysi] (in Finnish)

    OpenAIRE

    Tilli, Juha-Matti

    2014-01-01

    Analysis of measured X-ray diffraction (XRD) data from heterostructures with fitting analysis is discussed, for which computer program was written. Lattice constant and Poisson's ratio of a multi-compound layer is calculated from Vegard's law. Layers are strained in in-plane direction causing additional strain in out-of-plane direction and may be only partially strained. For crystals, wavelength-dependent electric susceptibility is represented as Fourier series, components of which are calcul...

  14. Fit Gap Analysis – The Role of Business Process Reference Models

    Directory of Open Access Journals (Sweden)

    Dejan Pajk

    2013-12-01

    Full Text Available Enterprise resource planning (ERP systems support solutions for standard business processes such as financial, sales, procurement and warehouse. In order to improve the understandability and efficiency of their implementation, ERP vendors have introduced reference models that describe the processes and underlying structure of an ERP system. To select and successfully implement an ERP system, the capabilities of that system have to be compared with a company’s business needs. Based on a comparison, all of the fits and gaps must be identified and further analysed. This step usually forms part of ERP implementation methodologies and is called fit gap analysis. The paper theoretically overviews methods for applying reference models and describes fit gap analysis processes in detail. The paper’s first contribution is its presentation of a fit gap analysis using standard business process modelling notation. The second contribution is the demonstration of a process-based comparison approach between a supply chain process and an ERP system process reference model. In addition to its theoretical contributions, the results can also be practically applied to projects involving the selection and implementation of ERP systems.

  15. Everything you wanted to know about data analysis and fitting but were afraid to ask

    CERN Document Server

    Young, Peter

    2015-01-01

    These notes describe how to average and fit numerical data that have been obtained either by simulation or measurement. Following an introduction on how to estimate various average values, they discuss how to determine error bars on those estimates, and how to proceed for combinations of measured values. Techniques for fitting data to a given set of models will be described in the second part of these notes. This primer equips readers to properly derive the results covered, presenting the content in a style suitable for a physics audience. It also includes scripts in python, perl and gnuplot for performing a number of tasks in data analysis and fitting, thereby providing readers with a useful reference guide.

  16. Analysis of umbu (Spondias tuberosa Arruda (Anacardiaceae)) in different landscape management regimes: a process of incipient domestication?

    Science.gov (United States)

    Lins Neto, Ernani Machado de Freitas; Peroni, Nivaldo; Maranhão, Christine Maria Carneiro; Maciel, Maria Inês Sucupira; de Albuquerque, Ulysses Paulino

    2012-07-01

    Plant domestication is an evolutionary process guided by human groups who modify the landscape for their needs. The objective of this study was to evaluate the phenotypic variations between populations of Spondias tuberosa Arruda (umbuzeiro) when subjected to different local landscape management strategies. The influence of the landscape management system on these populations was evaluated in five identified regional units (mountains, base of mountains, pastures, cultivated areas and home gardens). Ten individuals were randomly selected from each region and subjected to morphological and chemical fruit analysis. The diversity index, based on Simpson's index, was determined for the different populations. We then evaluated the morphological differences between the individual fruits from the distinct landscape areas. We observed no significant differences in morphological diversity between the areas studied. Our data suggest that the umbuzeiro specimens in this region may be in the process of incipient domestication.

  17. Matrix permeability of agriculture landscapes: an analysis of movements of the common frog (Rana temporaria)

    NARCIS (Netherlands)

    Vos, C.C.; Goedhart, P.W.; Lammertsma, D.R.; Spitzen-van der Sluijs, A.M.

    2007-01-01

    The implications of habitat fragmentation go beyond changes in the size and composition of suitable habitat patches. In fragmented landscapes, "matrix permeability" influences the dispersal of organisms, thereby affecting the persistence of populations in such landscapes. We investigated the effect

  18. Strategic Environmental Assessment Framework for Landscape-Based, Temporal Analysis of Wetland Change in Urban Environments

    Science.gov (United States)

    Sizo, Anton; Noble, Bram F.; Bell, Scott

    2016-03-01

    This paper presents and demonstrates a spatial framework for the application of strategic environmental assessment (SEA) in the context of change analysis for urban wetland environments. The proposed framework is focused on two key stages of the SEA process: scoping and environmental baseline assessment. These stages are arguably the most information-intense phases of SEA and have a significant effect on the quality of the SEA results. The study aims to meet the needs for proactive frameworks to assess and protect wetland habitat and services more efficiently, toward the goal of advancing more intelligent urban planning and development design. The proposed framework, adopting geographic information system and remote sensing tools and applications, supports the temporal evaluation of wetland change and sustainability assessment based on landscape indicator analysis. The framework was applied to a rapidly developing urban environment in the City of Saskatoon, Saskatchewan, Canada, analyzing wetland change and land-use pressures from 1985 to 2011. The SEA spatial scale was rescaled from administrative urban planning units to an ecologically meaningful area. Landscape change assessed was based on a suite of indicators that were subsequently rolled up into a single, multi-dimensional, and easy to understand and communicate index to examine the implications of land-use change for wetland sustainability. The results show that despite the recent extremely wet period in the Canadian prairie region, land-use change contributed to increasing threats to wetland sustainability.

  19. Analysis of riboswitch structure and function by an energy landscape framework.

    Science.gov (United States)

    Quarta, Giulio; Kim, Namhee; Izzo, Joseph A; Schlick, Tamar

    2009-11-06

    The thiamine pyrophosphate (TPP) riboswitch employs modular domains for binding TPP to form a platform for gene expression regulation. Specifically, TPP binding triggers a conformational switch in the RNA from a transcriptionally active "on" state to an inactive "off" state that concomitantly causes the formation of a terminator hairpin and halting of transcription. Here, clustering analysis of energy landscapes at different nucleotide lengths suggests a novel computational tool for analysis of the mechanics of transcription elongation in the presence or absence of the ligand. Namely, we suggest that the riboswitch's kinetics are tightly governed by a length-dependent switch, whereby the energy landscape has two clusters available during transcription elongation and where TPP's binding shifts the preference to one form. Significantly, the biologically active and inactive structures determined experimentally matched well the structures predominant in each computational set. These clustering/structural analyses combined with modular computational design suggest design principles that exploit the above features to analyze as well as create new functions and structures of RNA systems.

  20. Strategic Environmental Assessment Framework for Landscape-Based, Temporal Analysis of Wetland Change in Urban Environments.

    Science.gov (United States)

    Sizo, Anton; Noble, Bram F; Bell, Scott

    2016-03-01

    This paper presents and demonstrates a spatial framework for the application of strategic environmental assessment (SEA) in the context of change analysis for urban wetland environments. The proposed framework is focused on two key stages of the SEA process: scoping and environmental baseline assessment. These stages are arguably the most information-intense phases of SEA and have a significant effect on the quality of the SEA results. The study aims to meet the needs for proactive frameworks to assess and protect wetland habitat and services more efficiently, toward the goal of advancing more intelligent urban planning and development design. The proposed framework, adopting geographic information system and remote sensing tools and applications, supports the temporal evaluation of wetland change and sustainability assessment based on landscape indicator analysis. The framework was applied to a rapidly developing urban environment in the City of Saskatoon, Saskatchewan, Canada, analyzing wetland change and land-use pressures from 1985 to 2011. The SEA spatial scale was rescaled from administrative urban planning units to an ecologically meaningful area. Landscape change assessed was based on a suite of indicators that were subsequently rolled up into a single, multi-dimensional, and easy to understand and communicate index to examine the implications of land-use change for wetland sustainability. The results show that despite the recent extremely wet period in the Canadian prairie region, land-use change contributed to increasing threats to wetland sustainability.

  1. Land Cover and Landscape Diversity Analysis in the West Polesie Biosphere Reserve

    Science.gov (United States)

    Chmielewski, Szymon; Chmielewski, Tadeusz J.; Tompalski, Piotr

    2014-04-01

    The aim of this research was to present the land cover structure and landscape diversity in the West Polesie Biosphere Reserve. The land cover classification was performed using Object Based Image Analysis in Trimble eCognition Developer 8 software. The retrospective land cover changes analysis in 3 lake catchments (Kleszczów, Moszne, Bia³eW³odawskie Lakes)was performed on the basis of archival aerial photos taken in 1952, 1971, 1984, 1992, 2007 and one satellite scene from 2003 (IKONOS).On the basis of land cover map structure, Shannon diversity index was estimated with the moving window approach enabled in Fragstats software. The conducted research has shown that the land cover structure of the West Polesie Biosphere Reserve is diverse and can be simply described by selected landscape metrics. The highest level of land cover diversity, as showed by Shannon Diversity Index, was identified in the western part of the West Polesie Biosphere Reserve, which is closely related to the agricultural character of land cover structure in those regions. The examples of three regional retrospective land cover analyses demonstrated that the character of land cover structure has changed dramatically over the last 40 years.

  2. The effectiveness of FOBT vs. FIT: A meta-analysis on colorectal cancer screening test

    Science.gov (United States)

    Mousavinezhad, Maryam; Majdzadeh, Reza; Akbari Sari, Ali; Delavari, Alireza; Mohtasham, Farideh

    2016-01-01

    Background: After lung and prostate cancers, colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women after breast cancer worldwide. Every year, more than one million people are diagnosed with colorectal cancer worldwide and half of these patients die from this disease, making it the fourth leading cause of death in the world. This systematic review aimed to assess the effectiveness of the two colorectal diagnostic tests of FOBT (fecal occult blood test) and FIT (fecal immunochemical test)) in terms of technical performance. Methods: To retrieve the relevant evidence, appropriate medical databases such as Cochrane library, NHSEED, Scopus and Google scholar were searched from February 2013 to July 2014, using free-texts and Mesh. In this study, inclusion/exclusion criteria of the papers, randomized controlled trials, economic evaluations, systematic reviews, meta-analyses and meta-syntheses of the effectiveness of FIT versus FOBT tests in moderate-risk populations (age: 50 to 70 years), which had reported the least of such outcomes as sensitivity, specificity and clinical outcomes were reviewed. The analyses of the effectiveness outcomes were performed in the form of meta-analysis. Results: Five papers were eligible to be included in the final phase of the study for synthesis. FIT showed a better performance in participation and positivity rate. Moreover, in terms of false positive and negative rate, FIT showed fewer rates compared to FOBT (RR:-4.06; 95% CI (-7.89-0.24), and NN-scope (Number need to scope) (2.2% vs. 1.6%), and NN-screen (Number need to screen) (84% vs. 31-49% in different cut off levels) showed significant differences in FOBT vs. FIT, respectively. Conclusion: In the five included studies (3, 11-14), the acceptability of FIT was more than FOBT. However, in our meta-analysis, no difference was found between the two tests. FIT was significant in positivity rate and had a better performance in

  3. An Analysis of Physical Fitness Differences in Soccer,Handball,and Basketball

    Institute of Scientific and Technical Information of China (English)

    HUHong; ZHONGPu

    2002-01-01

    This study focuses on the evaluation of the differences of physical fitness among soccer players,handball players,and basktball players,and the investigation of the physical fitness structures of those players,The participants consisted of 160 elite players selected from university teams,Fourteen tests related to health and motor fitness were conducted.The results were subjected to a multivariate analysis of variance (MANOVA) to test the mean vector differences among the three groups of different sport.Nine out of the fourteen tests were of of significantly discriminating results regarding to different group,which include side step,abdominal strength,shuttle running,100m running,pull-up,1,500m running,trunk frunk flexion,grip strength and broad jump,as determined by a stepwise regression approach,MANOVA showed that there was a significant difference(P<0.001) of the mean vectors of the 9 tests among the three events,Discriminant function analysis showed that three discriminant functions were significant,whose correctness was testified by the classification analysis to be over 80.2%,it is demonstrated that elite handball players are good at agility,elite soccer players are speedy,and successful basketball players apparently possess preeeminent muscular strength and endurance.

  4. Comprehensive assessment and network analysis of the emerging genetic susceptibility landscape of prostate cancer.

    Science.gov (United States)

    Hicks, Chindo; Miele, Lucio; Koganti, Tejaswi; Vijayakumar, Srinivasan

    2013-01-01

    Recent advances in high-throughput genotyping have made possible identification of genetic variants associated with increased risk of developing prostate cancer using genome-wide associations studies (GWAS). However, the broader context in which the identified genetic variants operate is poorly understood. Here we present a comprehensive assessment, network, and pathway analysis of the emerging genetic susceptibility landscape of prostate cancer. We created a comprehensive catalog of genetic variants and associated genes by mining published reports and accompanying websites hosting supplementary data on GWAS. We then performed network and pathway analysis using single nucleotide polymorphism (SNP)-containing genes to identify gene regulatory networks and pathways enriched for genetic variants. We identified multiple gene networks and pathways enriched for genetic variants including IGF-1, androgen biosynthesis and androgen signaling pathways, and the molecular mechanisms of cancer. The results provide putative functional bridges between GWAS findings and gene regulatory networks and biological pathways.

  5. Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes

    Energy Technology Data Exchange (ETDEWEB)

    Baird, Nathan J. [National Inst. of Health (NIH), Bethesda, MD (United States); Inglese, James [National Inst. of Health (NIH), Bethesda, MD (United States); Ferré-D’Amaré, Adrian R. [National Inst. of Health (NIH), Bethesda, MD (United States)

    2015-12-07

    The structure and biological properties of RNAs are a function of changing cellular conditions, but comprehensive, simultaneous investigation of the effect of multiple interacting environmental variables is not easily achieved. We have developed an efficient, high-throughput method to characterize RNA structure and thermodynamic stability as a function of multiplexed solution conditions using Förster resonance energy transfer (FRET). In a single FRET experiment using conventional quantitative PCR instrumentation, 19,400 conditions of MgCl2, ligand and temperature are analysed to generate detailed empirical conformational and stability landscapes of the cyclic diguanylate (c-di-GMP) riboswitch. This method allows rapid comparison of RNA structure modulation by cognate and non-cognate ligands. Landscape analysis reveals that kanamycin B stabilizes a non-native, idiosyncratic conformation of the riboswitch that inhibits c-di-GMP binding. Our research demonstrates that allosteric control of folding, rather than direct competition with cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other structured RNA molecules.

  6. Landscape analysis and pattern of hurricane impact and circulation on mangrove forests of the everglades

    Science.gov (United States)

    Doyle, T.W.; Krauss, K.W.; Wells, C.J.

    2009-01-01

    The Everglades ecosystem contains the largest contiguous tract of mangrove forest outside the tropics that were also coincidentally intersected by a major Category 5 hurricane. Airborne videography was flown to capture the landscape pattern and process of forest damage in relation to storm trajectory and circulation. Two aerial video transects, representing different topographic positions, were used to quantify forest damage from video frame analysis in relation to prevailing wind force, treefall direction, and forest height. A hurricane simulation model was applied to reconstruct wind fields corresponding to the ground location of each video frame and to correlate observed treefall and destruction patterns with wind speed and direction. Mangrove forests within the storm's eyepath and in the right-side (forewind) quadrants suffered whole or partial blowdowns, while left-side (backwind) sites south of the eyewall zone incurred moderate canopy reduction and defoliation. Sites along the coastal transect sustained substantially more storm damage than sites along the inland transect which may be attributed to differences in stand exposure and/or stature. Observed treefall directions were shown to be non-random and associated with hurricane trajectory and simulated forewind azimuths. Wide-area sampling using airborne videography provided an efficient adjunct to limited ground observations and improved our spatial understanding of how hurricanes imprint landscape-scale patterns of disturbance. ?? 2009 The Society of Wetland Scientists.

  7. Landscape analysis of drone congregation areas of the honey bee, Apis mellifera.

    Science.gov (United States)

    Galindo-Cardona, Alberto; Monmany, A Carolina; Moreno-Jackson, Rafiné; Rivera-Rivera, Carlos; Huertas-Dones, Carlos; Caicedo-Quiroga, Laura; Giray, Tugrul

    2012-01-01

    Male honey bees fly and gather at Drone Congregation Areas (DCAs), where drones and queens mate in flight. DCAs occur in places with presumably characteristic features. Using previously described landscape characteristics and observations on flight direction of drones in nearby apiaries, 36 candidate locations were chosen across the main island of Puerto Rico. At these locations, the presence or absence of DCAs was tested by lifting a helium balloon equipped with queen-sex-pheromone-impregnated bait, and visually determining the presence of high numbers of drones. Because of the wide distribution of honey bees in Puerto Rico, it was expected that most of the potential DCAs would be used as such by drones and queens from nearby colonies. Eight DCAs were found in the 36 candidate locations. Locations with and without DCAs were compared in a landscape analysis including characteristics that were described to be associated with DCAs and others. Aspect (direction of slope) and density of trails were found to be significantly associated with the presence of DCAs.

  8. Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes

    Science.gov (United States)

    Baird, Nathan J.; Inglese, James; Ferré-D'Amaré, Adrian R.

    2015-12-01

    The structure and biological properties of RNAs are a function of changing cellular conditions, but comprehensive, simultaneous investigation of the effect of multiple interacting environmental variables is not easily achieved. We have developed an efficient, high-throughput method to characterize RNA structure and thermodynamic stability as a function of multiplexed solution conditions using Förster resonance energy transfer (FRET). In a single FRET experiment using conventional quantitative PCR instrumentation, 19,400 conditions of MgCl2, ligand and temperature are analysed to generate detailed empirical conformational and stability landscapes of the cyclic diguanylate (c-di-GMP) riboswitch. The method allows rapid comparison of RNA structure modulation by cognate and non-cognate ligands. Landscape analysis reveals that kanamycin B stabilizes a non-native, idiosyncratic conformation of the riboswitch that inhibits c-di-GMP binding. This demonstrates that allosteric control of folding, rather than direct competition with cognate effectors, is a viable approach for pharmacologically targeting riboswitches and other structured RNA molecules.

  9. A multilevel analysis of health-related physical fitness. The Portuguese sibling study on growth, fitness, lifestyle and health

    Science.gov (United States)

    Pereira, Sara; Todd Katzmarzyk, Peter; Gomes, Thayse Natacha; Souza, Michele; Chaves, Raquel Nichele; dos Santos, Fernanda Karina; Santos, Daniel; Hedeker, Donald; Maia, José

    2017-01-01

    This study investigates biological, behavioural and sociodemographic correlates of intra-pair similarities, and estimates sibling resemblance in health-related physical fitness (PF). The sample comprises 1101 biological siblings (525 females) aged 9–20 years. PF components and markers were: morphological [waist circumference (WC) and %body fat (%BF)], muscular [handgrip strength (GS) and standing long jump (SLJ)], motor [50-yard dash (50YD) and shuttle run (SR)], and cardiorespiratory (1-mile run). Biological maturation was assessed; physical activity (PA), TV viewing and socioeconomic status (SES) information was obtained. On average, older and more mature subjects are better performers in all PF components; PA was negatively associated with SR, while SES was negatively associated with SLJ and SR. A pattern was observed in the intraclass correlations (ρ) wherein same sex siblings demonstrate greater resemblance for most PF components (sister-sister: 0.35≤ ρ≤0.55; brother-brother: (0.25≤ρ≤0.60) than brother-sister pairs (BS) (0≤ρ≤0.15), except for %BF (ρBB>ρSS>ρBS), and the 1-mile run (ρSS>ρBS>ρBB). In conclusion, behavioural and sociodemographic correlates play different roles in siblings PF expression. Further, a significant familial PF resemblance was observed with different trends in different sibling types, probably due to variations in shared genetic factors and sociodemographic conditions. PMID:28187195

  10. A gradient analysis on urban sprawl and urban landscape pattern between 1985 and 2000 in the Pearl River Delta, China

    Science.gov (United States)

    Dai, Erfu; Wu, Zhuo; Du, Xiaodian

    2017-04-01

    Urbanization is an irreversible trend worldwide, especially in rapidly developing China. Accelerated urbanization has resulted in rapid urban sprawl and urban landscape pattern changes. Quantifying the spatiotemporal dynamics of urban land use and landscape pattern not only can reveal the characteristics of social transfer and economic development, but also can provide insights into the driving mechanisms of land use changes. In this study, we integrated remote sensing (RS), geographic information system (GIS), landscape metrics, and gradient analysis to quantitatively compare the spatiotemporal dynamics of land use, urban sprawl, and landscape pattern for nine cities in the Pearl River Delta from 1985‒2000. For the whole study region, urbanization was obvious. The results show an increase in urban buildup land and shrinkage of cropland in the Pearl River Delta. However, the nine cities differed greatly in terms of the process and magnitude of urban sprawl for both the spatial and temporal dimensions. This was most evident for the cities of Guangzhou and Shenzhen. Gradient analysis on urban landscape changes could deepen understanding of the stages of urban development and provide a scientific foundation for future urban planning and land management strategies in China.

  11. Innovation and entrepreneurship programs in US medical education: a landscape review and thematic analysis.

    Science.gov (United States)

    Niccum, Blake A; Sarker, Arnab; Wolf, Stephen J; Trowbridge, Matthew J

    2017-01-01

    Training in innovation and entrepreneurship (I&E) in medical education has become increasingly prevalent among medical schools to train students in complex problem solving and solution design. We aim to characterize I&E education in US allopathic medical schools to provide insight into the features and objectives of this growing field. I&E programs were identified in 2016 via structured searches of 158 US allopathic medical school websites. Program characteristics were identified from public program resources and structured phone interviews with program directors. Curricular themes were identified via thematic analysis of program resources, and themes referenced by >50% of programs were analyzed. Thirteen programs were identified. Programs had a median age of four years, and contained a median of 13 students. Programs were led by faculty from diverse professional backgrounds, and all awarded formal recognition to graduates. Nine programs spanned all four years of medical school and ten programs required a capstone project. Thematic analysis revealed seven educational themes (innovation, entrepreneurship, technology, leadership, healthcare systems, business of medicine, and enhanced adaptability) and two teaching method themes (active learning, interdisciplinary teaching) referenced by >50% of programs. The landscape of medical school I&E programs is rapidly expanding to address newfound skills needed by physicians due to ongoing changes in healthcare, but programs remain relatively few and small compared to class size. This landscape analysis is the first review of I&E in medical education and may contribute to development of a formal educational framework or competency model for current or future programs. AAMC: American Association of Medical Colleges; AMA: American Medical Association; I&E: Innovation and entrepreneurship.

  12. Applying information network analysis to fire-prone landscapes: implications for community resilience

    Directory of Open Access Journals (Sweden)

    Derric B. Jacobs

    2017-03-01

    Full Text Available Resilient communities promote trust, have well-developed networks, and can adapt to change. For rural communities in fire-prone landscapes, current resilience strategies may prove insufficient in light of increasing wildfire risks due to climate change. It is argued that, given the complexity of climate change, adaptations are best addressed at local levels where specific social, cultural, political, and economic conditions are matched with local risks and opportunities. Despite the importance of social networks as key attributes of community resilience, research using social network analysis on coupled human and natural systems is scarce. Furthermore, the extent to which local communities in fire-prone areas understand climate change risks, accept the likelihood of potential changes, and have the capacity to develop collaborative mitigation strategies is underexamined, yet these factors are imperative to community resiliency. We apply a social network framework to examine information networks that affect perceptions of wildfire and climate change in Central Oregon. Data were collected using a mailed questionnaire. Analysis focused on the residents' information networks that are used to gain awareness of governmental activities and measures of community social capital. A two-mode network analysis was used to uncover information exchanges. Results suggest that the general public develops perceptions about climate change based on complex social and cultural systems rather than as patrons of scientific inquiry and understanding. It appears that perceptions about climate change itself may not be the limiting factor in these communities' adaptive capacity, but rather how they perceive local risks. We provide a novel methodological approach in understanding rural community adaptation and resilience in fire-prone landscapes and offer a framework for future studies.

  13. K, L, and M shell datasets for PIXE spectrum fitting and analysis

    Science.gov (United States)

    Cohen, David D.; Crawford, Jagoda; Siegele, Rainer

    2015-11-01

    Routine PIXE analysis programs, like GUPIX, GEOPIXE and PIXAN generally perform at least two key functions firstly, the fitting of K, L and M characteristic lines X-ray lines to a background, including unfolding of overlapping lines and secondly, the use of a fitted primary Kα, Lα or Mα line area to determine the elemental concentration in a given matrix. To achieve these two results to better than 3-5% the data sets for fluorescence yields, emission rates, Coster-Kronig transitions and ionisation cross sections should be determined to better than 3%. There are many different theoretical and experimental K, L and M datasets for these parameters. How they are applied and used in analysis programs can vary the results obtained for both fitting and concentration determinations. Here we discuss several commonly used datasets for fluorescence yields, emission rates, Coster-Kronig transitions and ionisation cross sections for K, L and M subshells and suggests an optimum set to obtain consistent results for PIXE analyses across a range of elements with atomic numbers from 5 ⩽ Z ⩽ 100.

  14. Marginal Vertical Fit along the Implant-Abutment Interface: A Microscope Qualitative Analysis

    Directory of Open Access Journals (Sweden)

    Nicola Mobilio

    2016-09-01

    Full Text Available The aim of this study was to qualitatively evaluate the marginal vertical fit along two different implant-abutment interfaces: (1 a standard abutment on an implant and (2 a computer-aided-design/computer-aided-machine (CAD/CAM customized screw-retained crown on an implant. Four groups were compared: three customized screw-retained crowns with three different “tolerance” values (CAD-CAM 0, CAD-CAM +1, CAD-CAM −1 and a standard titanium abutment. Qualitative analysis was carried out using an optical microscope. Results showed a vertical gap significantly different from both CAD-CAM 0 and CAD-CAM −1, while no difference was found between standard abutment and CAD-CAM +1. The set tolerance in producing CAD/CAM screw-retained crowns plays a key role in the final fit.

  15. Finding Clothing That Fit through Cluster Analysis and Objective Interestingness Measures

    Science.gov (United States)

    Peña, Isis; Viktor, Herna L.; Paquet, Eric

    Clothes should fit consumers well, be aesthetically pleasing and comfortable. However, repeated studies of customers’ levels of satisfaction indicate that this is often not the case. For example, more robust males often find it difficult to find pants that are the correct length and fit their waists well. What, then, are the typical body profiles of the population? Would it be possible to identify the measurements that are of importance for different sizes and genders? Furthermore, assuming that we have access to an anthropometric database would there be a way to guide the data mining process to discover only those relevant body measurements that are of the most interest for apparel designers? This paper describes our results when addressing these questions through cluster analysis and interestingness measures-based feature selection. We explore a database containing anthropometric measurements as well as 3-D body scans, of a representative sample of the Dutch population.

  16. K, L, and M shell datasets for PIXE spectrum fitting and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, David D., E-mail: dcz@ansto.gov.au; Crawford, Jagoda; Siegele, Rainer

    2015-11-15

    Highlights: • Differences between several datasets commonly used by PIXE codes for spectrum fitting and concentration estimates have been highlighted. • A preferred option dataset was selected which includes ionisation cross sections, fluorescence yield, Coster–Kronig probabilities and X-ray line emission rates for K, L and M subshells. • For PIXE codes differences of several tens of percent can be seen for selected elements for L and M lines depending on the data sets selected. - Abstract: Routine PIXE analysis programs, like GUPIX, GEOPIXE and PIXAN generally perform at least two key functions firstly, the fitting of K, L and M characteristic lines X-ray lines to a background, including unfolding of overlapping lines and secondly, the use of a fitted primary Kα, Lα or Mα line area to determine the elemental concentration in a given matrix. To achieve these two results to better than 3–5% the data sets for fluorescence yields, emission rates, Coster–Kronig transitions and ionisation cross sections should be determined to better than 3%. There are many different theoretical and experimental K, L and M datasets for these parameters. How they are applied and used in analysis programs can vary the results obtained for both fitting and concentration determinations. Here we discuss several commonly used datasets for fluorescence yields, emission rates, Coster–Kronig transitions and ionisation cross sections for K, L and M subshells and suggests an optimum set to obtain consistent results for PIXE analyses across a range of elements with atomic numbers from 5 ⩽ Z ⩽ 100.

  17. AN ANALYSIS ON THE DETERMINANTS OF SERVICE QUALITY PERCEIVED BY MEMBERS OF THE FITNESS CENTER

    Directory of Open Access Journals (Sweden)

    Kadir YILDIZ

    2016-12-01

    Full Text Available In this research, it is aimed to determine the determinants of service quality perceived by fitness center members. Scanning model from quantitative research methods was used in the research. The study group consisted of 301 women and 390 men in total 691 members who participated the research voluntarily and were selected through an easily accessible sample. The "Sport-Fitness Centers Perceived Service Quality Scale (SFC-PSQS" developed by Uçan (2007 was used in the study. In the analysis of the data, independent t-test, correlation analysis and logistic regression tests were applied. According to obtained findings, significant and moderate relationships were determined between service quality sub-dimensions in positive direction whereas Independent T test results showed that service quality perceptions of participants who evaluated the program as expensive were found to be significantly lower in all sub-dimensions. Considering the logistic regression results, it was determined that variable of "physical environment quality" from perceived service quality sub-dimensions had an effect on the level of program fees of the members. It seems that 1 unit increase in physical environment quality variable caused 6.1% decrease in "program fee prediction" related to odds value. It can be stated that 11% of the total variance of program fee levels predicts perceived service quality. As a result, it is considered that only one factor cannot be effective in ensuring the continuity of sport-fitness center customers and the sustainability of the business. This is because factors such as customer expectations, equipment, experience of fitness center, customer loyalty, physical appearance that may affect individual consumer satisfaction are important factors.

  18. Electrical signature analysis to quantify human and animal performance on fitness and therapy equipment such as a treadmill

    Science.gov (United States)

    Cox, Daryl F.; Hochanadel, Charles D.; Haynes, Howard D.

    2010-05-18

    The invention is a human and animal performance data acquisition, analysis, and diagnostic system for fitness and therapy devices having an interface box removably disposed on incoming power wiring to a fitness and therapy device, at least one current transducer removably disposed on said interface box for sensing current signals to said fitness and therapy device, and a means for analyzing, displaying, and reporting said current signals to determine human and animal performance on said device using measurable parameters.

  19. Hydrological resiliency in the Western Boreal Plains: classification of hydrological responses using wavelet analysis to assess landscape resilience

    Science.gov (United States)

    Probert, Samantha; Kettridge, Nicholas; Devito, Kevin; Hannah, David; Parkin, Geoff

    2017-04-01

    The Boreal represents a system of substantial resilience to climate change, with minimal ecological change over the past 6000 years. However, unprecedented climatic warming, coupled with catchment disturbances could exceed thresholds of hydrological function in the Western Boreal Plains. Knowledge of ecohydrological and climatic feedbacks that shape the resilience of boreal forests has advanced significantly in recent years, but this knowledge is yet to be applied and understood at landscape scales. Hydrological modelling at the landscape scale is challenging in the WBP due to diverse, non-topographically driven hydrology across the mosaic of terrestrial and aquatic ecosystems. This study functionally divides the geologic and ecological components of the landscape into Hydrologic Response Areas (HRAs) and wetland, forestland, interface and pond Hydrologic Units (HUs) to accurately characterise water storage and infer transmission at multiple spatial and temporal scales. Wavelet analysis is applied to pond and groundwater levels to describe the patterns of water storage in response to climate signals; to isolate dominant controls on hydrological responses and to assess the relative importance of physical controls between wet and dry climates. This identifies which components of the landscape exhibit greater magnitude and frequency of variability to wetting and drying trends, further to testing the hierarchical framework for hydrological storage controls of: climate, bedrock geology, surficial geology, soil, vegetation, and topography. Classifying HRA and HU hydrological function is essential to understand and predict water storage and redistribution through drought cycles and wet periods. This work recognises which landscape components are most sensitive under climate change and disturbance and also creates scope for hydrological resiliency research in Boreal systems by recognising critical landscape components and their role in landscape collapse or catastrophic

  20. SPR imaging based electronic tongue via landscape images for complex mixture analysis.

    Science.gov (United States)

    Genua, Maria; Garçon, Laurie-Amandine; Mounier, Violette; Wehry, Hillary; Buhot, Arnaud; Billon, Martial; Calemczuk, Roberto; Bonnaffé, David; Hou, Yanxia; Livache, Thierry

    2014-12-01

    Electronic noses/tongues (eN/eT) have emerged as promising alternatives for analysis of complex mixtures in the domain of food and beverage quality control. We have recently developed an electronic tongue by combining surface plasmon resonance imaging (SPRi) with an array of non-specific and cross-reactive receptors prepared by simply mixing two small molecules in varying and controlled proportions and allowing the mixtures to self-assemble on the SPRi prism surface. The obtained eT generated novel and unique 2D continuous evolution profiles (CEPs) and 3D continuous evolution landscapes (CELs) based on which the differentiation of complex mixtures such as red wine, beer and milk were successful. The preliminary experiments performed for monitoring the deterioration of UHT milk demonstrated its potential for quality control applications. Furthermore, the eT exhibited good repeatability and stability, capable of operating after a minimum storage period of 5 months.

  1. Self-assembly with colloidal clusters: facile crystal design using connectivity landscape analysis.

    Science.gov (United States)

    Zanjani, Mehdi B; Crocker, John C; Sinno, Talid

    2017-08-29

    Recent experimental and theoretical studies demonstrate that prefabricated micron-scale colloidal clusters functionalized with DNA oligomers offer a practical way for introducing anisotropic interactions, significantly extending the scope of DNA-mediated colloidal assembly, and enabling the formation of interesting crystalline superstructures that are otherwise inaccessible with short-ranged, spherically symmetric interactions. However, it is apparent that the high-dimensional parameter space that defines the geometric and interaction properties of such systems poses an obstacle to assembly design and optimization. Here, we present a geometrical analysis that generates connectivity landscapes for target superstructures, greatly reducing the space over which subsequent experimental trials must search. We focus on several superstructures that are assembled from binary systems comprised of 'merged' or 'sintered' tetrahedral clusters and single spheres. We also validate and extend the analytical constraint approach with direct MD simulations of superstructure nucleation and growth.

  2. Thermal Infrared Remote Sensing for Analysis of Landscape Ecological Processes: Current Insights and Trends. Chapter 3

    Science.gov (United States)

    Quattrochi, Dale A.; Luvall, Jeffrey C.

    2014-01-01

    NASA or NOAA Earth-observing satellites are not the only space-based TIR platforms. The European Space Agency (ESA), the Chinese, and other countries have in orbit or plan to launch TIR remote sensing systems. Satellite remote sensing provides an excellent opportunity to study land-atmosphere energy exchanges at the regional scale. A predominant application of TIR data has been in inferring evaporation, evapotranspiration (ET), and soil moisture. In addition to using TIR data for ET and soil moisture analysis over vegetated surfaces, there is also a need for using these data for assessment of drought conditions. The concept of ecological thermodynamics provides a quantification of surface energy fluxes for landscape characterization in relation to the overall amount of energy input and output from specific land cover types.

  3. Mapping the dengue scientific landscape worldwide: a bibliometric and network analysis

    Directory of Open Access Journals (Sweden)

    Fabio Batista Mota

    Full Text Available BACKGROUND Despite the current global trend of reduction in the morbidity and mortality of neglected diseases, dengue’s incidence has increased and occurrence areas have expanded. Dengue also persists as a scientific and technological challenge since there is no effective treatment, vaccine, vector control or public health intervention. Combining bibliometrics and social network analysis methods can support the mapping of dengue research and development (R&D activities worldwide. OBJECTIVES The aim of this paper is to map the scientific scenario related to dengue research worldwide. METHODS We use scientific publication data from Web of Science Core Collection - articles indexed in Science Citation Index Expanded (SCI-EXPANDED - and combine bibliometrics and social network analysis techniques to identify the most relevant journals, scientific references, research areas, countries and research organisations in the dengue scientific landscape. FINDINGS Our results show a significant increase of dengue publications over time; tropical medicine and virology as the most frequent research areas and biochemistry and molecular biology as the most central area in the network; USA and Brazil as the most productive countries; and Mahidol University and Fundação Oswaldo Cruz as the main research organisations and the Centres for Disease Control and Prevention as the most central organisation in the collaboration network. MAIN CONCLUSIONS Our findings can be used to strengthen a global knowledge platform guiding policy, planning and funding decisions as well as to providing directions to researchers and institutions. So that, by offering to the scientific community, policy makers and public health practitioners a mapping of the dengue scientific landscape, this paper has aimed to contribute to upcoming debates, decision-making and planning on dengue R&D and public health strategies worldwide.

  4. Postmodern landscape architecture: theoretical, compositional characteristics and design elements with the analysis of 25 projects

    OpenAIRE

    Eplényi Anna; Oláh-Christian Brigitta

    2015-01-01

    This paper endeavours to highlight three aspects of postmodern landscape design: theoretical basis, composition and design elements. Postmodern theories, philosophy influenced the language of the postmodern landscape architecture and got materialized in the use of narratives, eclecticism, the Rhizome-principle. Postmodern landscape composition can be associated with anti-hierarchy, unusual structures, landforms, and playful moods. Postmodern design elements consist of the strong graphical use...

  5. Postmodern landscape architecture: theoretical, compositional characteristics and design elements with the analysis of 25 projects

    Directory of Open Access Journals (Sweden)

    Eplényi Anna

    2015-12-01

    Full Text Available This paper endeavours to highlight three aspects of postmodern landscape design: theoretical basis, composition and design elements. Postmodern theories, philosophy influenced the language of the postmodern landscape architecture and got materialized in the use of narratives, eclecticism, the Rhizome-principle. Postmodern landscape composition can be associated with anti-hierarchy, unusual structures, landforms, and playful moods. Postmodern design elements consist of the strong graphical use of colour and pavements, bizarre water features, unusual structures and buildings, postmodern sculptures and thematic garden details. 25 analysed projects try to capture the essence of postmodernism in landscape architecture as well as to reveal points of intersection within these projects.

  6. Fuzzy Modelling applied to the Analysis of Landscape: A proposal for participatory environmental assessment

    Directory of Open Access Journals (Sweden)

    Lucirene Vitória Góes França

    2014-11-01

    Full Text Available This paper aims to show the use of fuzzy logic as inference tool to decision support in analyzes of the landscape. For this, was created a mathematical model in order to express more realistically the environmental condition of the landscape. Through the construction of a environmental quality fuzzy index for the landscape, with emphasis on physical, biotic and social environments, as well as weighting criteria (severity, significance and magnitude, it was possible to articulate a method to evaluation harmful human actions to the environment, which are often subjectively treated, by the presence of uncertainty and personal considerations... Keywords: Landscape; Fuzzy; Jundiai-Mirim River.

  7. Spatial Analysis of Agricultural Landscape and Hymenoptera Biodiversity at Cianjur Watershed

    Directory of Open Access Journals (Sweden)

    YAHERWANDI

    2006-12-01

    Full Text Available Hymenoptera is one of the four largest insect order (the other three are Coleoptera, Diptera, and Lepidoptera. There are curerently over 115 000 described Hymenoptera species. It is clear that Hymenoptera is one of the major components of insect biodiversity. However, Hymenoptera biodiversity is affected by ecology, environment, and ecosystem management. In an agricultural areas, the spatial structure, habitat diversity, and habitat composition may vary from cleared landscapes to structurally rich landscape. Thus, it is very likely that such large-scale spatial patterns (landscape effects may influence local biodiversity and ecological functions. Therefore, the objective of this research were to study diversity and configuration elements of agricultural landscapes at Cianjur Watershed with geographical information sytems (GIS and its influence on Hymenoptera biodiversity. The structural differences between agricultural landscapes of Nyalindung, Gasol, and Selajambe were characterized by patch analyst with ArcView 3.2 of digital land use data. Results indicated that class of land uses of Cianjur Watershed landscape were housing, mixed gardens, talun and rice, vegetable, and corn fields. Landscape structure influenced the biodiversity of Hymenoptera. Species richness and the species diversity were higher in Nyalindung landscape compare to Gasol and Selajambe landscape.

  8. [Molecular genetic analysis of wild soybean (Glycine soja Sieb. & Zucc.) population structure in anthropogenic and natural landscapes of Primorskii krai].

    Science.gov (United States)

    Nedoluzhko, A V; Tikhonov, A V; Dorokhov, D B

    2008-08-01

    The data are presented on genetic population structure of wild soybean growing in natural and anthropogenically disturbed landscapes of Primorskii krai of the Russian Federation. Comparative analysis showed that wild soybean populations exposed to anthropogenic influence exhibited lower genetic diversity than natural populations. Recommendations on conservation of the wild plant gene pools using comparative data on population genetic structures are made.

  9. Automatic scatter detection in fluorescence landscapes by means of spherical principal component analysis

    DEFF Research Database (Denmark)

    Kotwa, Ewelina Katarzyna; Jørgensen, Bo Munk; Brockhoff, Per B.;

    2013-01-01

    In this paper, we introduce a new method, based on spherical principal component analysis (S‐PCA), for the identification of Rayleigh and Raman scatters in fluorescence excitation–emission data. These scatters should be found and eliminated as a prestep before fitting parallel factor analysis...... this drawback, we implement the fast S‐PCA in the scatter identification routine. Moreover, an additional pattern interpolation step that complements the method, based on robust regression, will be applied. In this way, substantial time savings are gained, and the user's engagement is restricted to a minimum...

  10. Approaches to automatic parameter fitting in a microscopy image segmentation pipeline: An exploratory parameter space analysis

    Directory of Open Access Journals (Sweden)

    Christian Held

    2013-01-01

    Full Text Available Introduction: Research and diagnosis in medicine and biology often require the assessment of a large amount of microscopy image data. Although on the one hand, digital pathology and new bioimaging technologies find their way into clinical practice and pharmaceutical research, some general methodological issues in automated image analysis are still open. Methods: In this study, we address the problem of fitting the parameters in a microscopy image segmentation pipeline. We propose to fit the parameters of the pipeline′s modules with optimization algorithms, such as, genetic algorithms or coordinate descents, and show how visual exploration of the parameter space can help to identify sub-optimal parameter settings that need to be avoided. Results: This is of significant help in the design of our automatic parameter fitting framework, which enables us to tune the pipeline for large sets of micrographs. Conclusion: The underlying parameter spaces pose a challenge for manual as well as automated parameter optimization, as the parameter spaces can show several local performance maxima. Hence, optimization strategies that are not able to jump out of local performance maxima, like the hill climbing algorithm, often result in a local maximum.

  11. Approaches to automatic parameter fitting in a microscopy image segmentation pipeline: An exploratory parameter space analysis

    Science.gov (United States)

    Held, Christian; Nattkemper, Tim; Palmisano, Ralf; Wittenberg, Thomas

    2013-01-01

    Introduction: Research and diagnosis in medicine and biology often require the assessment of a large amount of microscopy image data. Although on the one hand, digital pathology and new bioimaging technologies find their way into clinical practice and pharmaceutical research, some general methodological issues in automated image analysis are still open. Methods: In this study, we address the problem of fitting the parameters in a microscopy image segmentation pipeline. We propose to fit the parameters of the pipeline's modules with optimization algorithms, such as, genetic algorithms or coordinate descents, and show how visual exploration of the parameter space can help to identify sub-optimal parameter settings that need to be avoided. Results: This is of significant help in the design of our automatic parameter fitting framework, which enables us to tune the pipeline for large sets of micrographs. Conclusion: The underlying parameter spaces pose a challenge for manual as well as automated parameter optimization, as the parameter spaces can show several local performance maxima. Hence, optimization strategies that are not able to jump out of local performance maxima, like the hill climbing algorithm, often result in a local maximum. PMID:23766941

  12. Spatiotemporal Dynamics and Fitness Analysis of Global Oil Market: Based on Complex Network

    Science.gov (United States)

    Wang, Minggang; Fang, Guochang; Shao, Shuai

    2016-01-01

    We study the overall topological structure properties of global oil trade network, such as degree, strength, cumulative distribution, information entropy and weight clustering. The structural evolution of the network is investigated as well. We find the global oil import and export networks do not show typical scale-free distribution, but display disassortative property. Furthermore, based on the monthly data of oil import values during 2005.01–2014.12, by applying random matrix theory, we investigate the complex spatiotemporal dynamic from the country level and fitness evolution of the global oil market from a demand-side analysis. Abundant information about global oil market can be obtained from deviating eigenvalues. The result shows that the oil market has experienced five different periods, which is consistent with the evolution of country clusters. Moreover, we find the changing trend of fitness function agrees with that of gross domestic product (GDP), and suggest that the fitness evolution of oil market can be predicted by forecasting GDP values. To conclude, some suggestions are provided according to the results. PMID:27706147

  13. 医疗建筑景观空间结构剖析%MEDICAL BUILDING LANDSCAPE SPATIAL STRUCTURE ANALYSIS

    Institute of Scientific and Technical Information of China (English)

    张羽飞

    2016-01-01

    From the significant of medical building landscape design, the article overviews the design features, and based on hospital spatial and functions analyzes the key issues of landscape design; proposes deeper analysis of medial landscape design patterns to make the theory more systematic and complete.%文章从医疗建筑景观环境设计的重要性出发,概述了医疗建筑景观环境的设计特点,并根据医院空间的功能分析了景观设计的重点,建议更深层次地剖析医疗景观的设计模式,使其理论更加系统化,完整化。

  14. CFD Analysis of Experimental Wing and Winglet for FalconLAUNCH 8 and the ExFIT Program

    Science.gov (United States)

    2010-03-01

    CFD Analysis of Experimental Wing and Winglet for FalconLAUNCH 8 and the ExFIT Program THESIS Benjamin P. Switzer, Second Lieutenant, USAF AFIT/GAE...to copyright protection in the United States. AFIT/GAE/ENY/10-M25 CFD Analysis of Experimental Wing and Winglet for FalconLAUNCH 8 and the ExFIT...this analysis focused on the effects caused by shock waves forming on the winglet and their impact on the lifting characteristics and temperature

  15. The ecological structures as components of flood and erosion vulnerability analysis in costal landscapes

    Science.gov (United States)

    Valentini, E.; Taramelli, A.; Martina, M.; Persichillo, M. G.; Casarotti, C.; Meisina, C.

    2014-12-01

    The direct and the indirect changes of natural habitats for coastal development can affect the level of exposure to erosion and flooding (inundation). Although engineered structures are still preferred for coastal safety there is an increasing number of applications of ecosystem-based solutions worldwide as the building with nature approaches and the arising natural capital evaluation. A question to which we should respond, is the possibility of using the wide range of satellite data and the already available Earth Observation based products to make a synoptic structural and environmental vulnerability assessment. By answering to this, we could also understand, if and how many markers/signals can be identified in the landscape components, to define transitions to and from nonlinear processes - to and from scale invariant spatial distributions- characterizing the evolution of the environmental patch size mosaic, the landscape. The Wadden Sea, in example, is a productive estuarine area in the south-eastern coastal zone of the North Sea. It is characterized by extensive tidal mud flats, saltmarshes and by the tidal channel network between the mainland and the chain of islands along the North Sea side. The area has a UNESCO World Heritage Status and a Natura 2000 status. Here, we identified thresholds to distinguish spatial and temporal patterns controlled by changes in environmental variables. These patterns are represented by the cover percent and by the structural level of vegetation and sediment/soil in each identified patch. The environmental variables are those able to act on the patch size distribution as the forcing factors from the sea (wind and waves fields) or from the climate and the hydrology drivers. The Bayesian approach defines the dependencies of the spatial patch size distribution from the major flooding and erosion environmental variables. When the analysis is scaled up from the ecosystem units to the landscape level thanks to the satellite

  16. FREQFIT: Computer program which performs numerical regression and statistical chi-squared goodness of fit analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hofland, G.S.; Barton, C.C.

    1990-10-01

    The computer program FREQFIT is designed to perform regression and statistical chi-squared goodness of fit analysis on one-dimensional or two-dimensional data. The program features an interactive user dialogue, numerous help messages, an option for screen or line printer output, and the flexibility to use practically any commercially available graphics package to create plots of the program`s results. FREQFIT is written in Microsoft QuickBASIC, for IBM-PC compatible computers. A listing of the QuickBASIC source code for the FREQFIT program, a user manual, and sample input data, output, and plots are included. 6 refs., 1 fig.

  17. Biased random walks, lyapunov functions, and stochastic analysis of best fit bin packing

    Energy Technology Data Exchange (ETDEWEB)

    Kenyon, C. [CNRS, Lyon (France); Rabani, Y. [Technion, Haifa (Israel); Sinclair, A. [Univ. of California, Berkeley, CA (United States)

    1996-12-31

    We study the average case performance of the Best Fit algorithm for on-line bin packing under the distribution U(j,k), in which the item sizes are uniformly distributed in the discrete range (1/k, 2/k,..., j/k). Our main result is that, in the case j = k - 2, the expected waste for an infinite stream of items remains bounded. This settles an open problem posed recently by Coffman et al. It is also the first result which involves a detailed analysis of the infinite multi-dimensional Markov chain underlying the algorithm.

  18. Comparative analysis of physical fitness of students and cadets NUCPU to perform professional duties

    Directory of Open Access Journals (Sweden)

    Vitaly Kolokolov

    2014-12-01

    Full Text Available Purpose: to determine differences in physical training of cadets and students I rate faculties "Civil Defense", "Fire", "Technogenic and Environmental". Material and Methods: the study was conducted on the basis of educational and sports complex of the National University of Civil Defence of Ukraine. Students studied 80 boys and 80 students-boys. Results: a comparative analysis of the physical fitness of students and students. The results of testing Conclusions: set the difference in terms of performance but only if the three exercises: pull a translated, long jump, shuttle run, which allows you to optimize the physical training of cadets and students considering their future careers.

  19. FREQFIT: Computer program which performs numerical regression and statistical chi-squared goodness of fit analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hofland, G.S.; Barton, C.C.

    1990-10-01

    The computer program FREQFIT is designed to perform regression and statistical chi-squared goodness of fit analysis on one-dimensional or two-dimensional data. The program features an interactive user dialogue, numerous help messages, an option for screen or line printer output, and the flexibility to use practically any commercially available graphics package to create plots of the program`s results. FREQFIT is written in Microsoft QuickBASIC, for IBM-PC compatible computers. A listing of the QuickBASIC source code for the FREQFIT program, a user manual, and sample input data, output, and plots are included. 6 refs., 1 fig.

  20. [Aging Process of Puer Black Tea Studied by FTIR Spectroscopy Combined with Curve-Fitting Analysis].

    Science.gov (United States)

    Li, Dong-yu; Shi, You-ming; Yi, Shi Lai

    2015-07-01

    For better determination of the chemical components in the Puer black tea, Fourier transform infrared spectroscopy was used for obtaining vibrational spectra of Puer black tea at different aging time. Fourier transform infrared (FTIR) spectra indicated that the chemical components had change in Puer black tea at different aging time. The leaf of Puer black tea was a complex system, its Fourier transform infrared spectrum showed a total overlap of each absorption spectrum of various components. Each band represented an overall overlap of some characteristic absorption peaks of functional groups in the Puer black tea. In order to explore the change of characteristic absorption peaks of functional groups with aging time, the prediction positions and the number of second peaks in the range of 1900-900 cm(-1) were determined by Fourier self-deconvolution at first, and later the curve fitting analysis was performed in this overlap band. At different aging time of Puer black tea, the wave number of second peaks of amide II, tea polyphenol, pectin and polysaccharides at overlap band were assigned by curve fitting analysis. The second peak at 1520 cm(-1) was characteristic absorption band of amide II, the second peaks of tea polyphenol and pectin appeared at 1278 and 1103 cm(-1) respectively. Two second peaks at 1063 and 1037 cm(-1), corresponds mainly to glucomannan and arabinan. The relative area of these second peaks could be indicated the content of protein, tea polyphenol, pectin and polysaccharides in the Puer black tea. The results of curve fitting analysis showed that the relative area of amide II was increasing first and then decreasing, it indicated the change of protein in Puer black tea. At the same time, the content of tea polyphenol and pectin were decreased with the increase of aging time, but the glucomannan and arabinan were increased in reverse. It explained that the bitter taste was become weak and a sweet taste appeared in the tea with the increase of

  1. Fitness cost

    DEFF Research Database (Denmark)

    Nielsen, Karen L.; Pedersen, Thomas M.; Udekwu, Klas I.

    2012-01-01

    of each isolate was determined in a growth competition assay with a reference isolate. Significant fitness costs of 215 were determined for the MRSA isolates studied. There was a significant negative correlation between number of antibiotic resistances and relative fitness. Multiple regression analysis...... to that seen in Denmark. We propose a significant fitness cost of resistance as the main bacteriological explanation for the disappearance of the multiresistant complex 83A MRSA in Denmark following a reduction in antibiotic usage.......Denmark and several other countries experienced the first epidemic of methicillin-resistant Staphylococcus aureus (MRSA) during the period 196575, which was caused by multiresistant isolates of phage complex 83A. In Denmark these MRSA isolates disappeared almost completely, being replaced by other...

  2. X-ray diffraction from thin films : Size/strain analysis and whole pattern fitting

    Energy Technology Data Exchange (ETDEWEB)

    Scardi, P. [Trento Univ. (Italy). Dept. of Materials Engineering

    1996-09-01

    Line Profile Analysis (LPA) and whole pattern fitting may be used with success for the characterization of thin films from XRD data collected with the traditional Bragg-Brentano geometry. The size/strain analysis was conducted by an integrated procedure of profile modelling-assisted Fourier analysis, in order to measure the content of lattice imperfections and crystalline domain size along the growth direction in heteroepitaxial thin films. The microstructure of these films is typical of several PVD processes for the production of highly textured and low-defect thin crystalline layers. The same analysis could be conducted on random thin films as well, and in this case it is possible to determine an average crystallite size and shape. As will be shown in the paper, structural and microstructural parameters obtained by these methods may be correlated with thin film properties of technological interest. The whole pattern analysis may be used to obtain the information contained in a wide region of the diffraction pattern. This approach, currently used for the quantitative analysis of phase mixtures in traditional powder samples, was modified to account both for the size/strain effects, according to a simplified LPA, and for the structure of thin films and multi-layer systems. In this way, a detailed analysis based on a structural model for the present phases can be performed considering the real geometry of these samples. In particular, the quantitative phase analysis could be conducted in terms of layer thickness instead of volume or weight fractions.

  3. Chapter 10: Geographic information system landscape analysis using GTR 220 concepts

    Science.gov (United States)

    M. North; R.M. Boynton; P.A. Stine; K.F. Shipley; E.C. Underwood; N.E. Roth; J.H. Viers; J.F. Quinn

    2012-01-01

    Forest Service General Technical Report "An Ecosystem Management Strategy for Sierran Mixed-Conifer Forests" (hereafter GTR 220) (North et al. 2009) emphasizes increasing forest heterogeneity throughout a range of spatial scales including within-stand microsites, individual stands, watersheds, and entire landscapes. For fuels reduction, various landscape...

  4. Spatial pattern analysis for quantification of landscape structure of Tadoba-Andhari Tiger Reserve, Central India

    Institute of Scientific and Technical Information of China (English)

    Ambica Paliwal; Vinod Bihari Mathur

    2014-01-01

    Landscape structure is often regarded as an important factor that governs the distribution and abundance of species. Therefore it is critical to understand the landscapes and their dynamics. Patterns of landscape elements strongly influence the ecological characteristics. This study was designed to document and map the current status of the tropi-cal dry deciduous forest of the Tadoba-Andhari Tiger Reserve (TATR), Central India, (using IRS P6 LISS IV data) and to describe its landscape structure at three levels of organization viz. landscape, class, and patch. The study area was classified into 10 land cover classes that include 6 vegetation classes. The landscape structure was analyzed using FRAG-STATS using 12 set of indices. The TATR landscapes have a total of 2,307 patches with a mean patch size of 25.67 ha and patch density of 1.7 patches per km². Amongst all land cover classes, mixed bamboo forest is dominant-it occupied maximum area (77.99%)-while riparian forest is least represented (0.32%). Mixed forest has maximum number of patches among all vegetation classes. Results have shown that despite being dominant in the area, mixed bamboo forest has low patch density (0.25/100 ha). Dominance of mixed bamboo forest is attributed to large patch sizes and not to the number of patches. This study has focussed on the approach of integrating satellite forest classification and forest inven-tory data for studying forest landscape patterns.

  5. Landscapes of the Anthropocene

    DEFF Research Database (Denmark)

    Pawson, Eric; Christensen, Andreas Aagaard

    2014-01-01

    The purpose of this chapter is to explore the dramatic increase in the power of human agency over the environment through an analysis of landscape change. It discusses the processes that have shaped new landscapes in the capitalist world before focusing on one place that is characteristic of the ...

  6. Situated knowledge of pathogenic landscapes in Ghana: Understanding the emergence of Buruli ulcer through qualitative analysis.

    Science.gov (United States)

    Tschakert, Petra; Ricciardi, Vincent; Smithwick, Erica; Machado, Mario; Ferring, David; Hausermann, Heidi; Bug, Leah

    2016-02-01

    Successfully addressing neglected tropical diseases requires nuanced understandings of pathogenic landscapes that incorporate situated, contexualized community knowledge. In the case of Buruli ulcer (BU), the role of social science is vital to investigate complex human-environment interactions and navigate different ways of knowing. We analyze a set of qualitative data from our interdisciplinary project on BU in Ghana, drawing from participatory mapping, focus group discussions, semi-structured interviews, and open-ended survey questions to explore how people in endemic and non-endemic areas see themselves embedded in changing environmental and social landscapes. We pay particular attention to landscape disturbance through logging and small-scale alluvial gold mining. The results from our participatory research underscore the holistic nature of BU emergence in landscapes, encapsulated in partial and incomplete local descriptions, the relevance of collective learning to distill complexity, and the potential of rich qualitative data to inform quantitative landscape-disease models.

  7. Tracing the Potential Flow of Consumer Data: A Network Analysis of Prominent Health and Fitness Apps.

    Science.gov (United States)

    Grundy, Quinn; Held, Fabian P; Bero, Lisa A

    2017-06-28

    A great deal of consumer data, collected actively through consumer reporting or passively through sensors, is shared among apps. Developers increasingly allow their programs to communicate with other apps, sensors, and Web-based services, which are promoted as features to potential users. However, health apps also routinely pose risks related to information leaks, information manipulation, and loss of information. There has been less investigation into the kinds of user data that developers are likely to collect, and who might have access to it. We sought to describe how consumer data generated from mobile health apps might be distributed and reused. We also aimed to outline risks to individual privacy and security presented by this potential for aggregating and combining user data across apps. We purposively sampled prominent health and fitness apps available in the United States, Canada, and Australia Google Play and iTunes app stores in November 2015. Two independent coders extracted data from app promotional materials on app and developer characteristics, and the developer-reported collection and sharing of user data. We conducted a descriptive analysis of app, developer, and user data collection characteristics. Using structural equivalence analysis, we conducted a network analysis of sampled apps' self-reported sharing of user-generated data. We included 297 unique apps published by 231 individual developers, which requested 58 different permissions (mean 7.95, SD 6.57). We grouped apps into 222 app families on the basis of shared ownership. Analysis of self-reported data sharing revealed a network of 359 app family nodes, with one connected central component of 210 app families (58.5%). Most (143/222, 64.4%) of the sampled app families did not report sharing any data and were therefore isolated from each other and from the core network. Fifteen app families assumed more central network positions as gatekeepers on the shortest paths that data would have to

  8. Marc Treib: Representing Landscape Architecture

    DEFF Research Database (Denmark)

    Braae, Ellen Marie

    2008-01-01

    The editor of Representing Landscape Architecture, Marc Treib, argues that there is good reason to evaluate the standard practices of representation that landscape architects have been using for so long. In the rush to the promised land of computer design these practices are now in danger of being...... left by the wayside. The 14 often both fitting and well crafted contributions of this publication offer an approach to how landscape architecture has been and is currently represented; in the design study, in presentation, in criticism, and in the creation of landscape architecture....

  9. Fifty-year spatiotemporal analysis of landscape changes in the Mont Saint-Hilaire UNESCO Biosphere Reserve (Quebec, Canada).

    Science.gov (United States)

    Béliveau, Marc; Germain, Daniel; Ianăş, Ana-Neli

    2017-05-01

    Diachronic analysis with a GIS-based classification of land-use changes based on aerial photographs, orthophotos, topographic maps, geotechnical reports, urban plans, and using landscape metrics has permitted insight into the driving forces responsible for landscape fragmentation in the Mont Saint-Hilaire (MSH) Biosphere Reserve over the period 1958-2015. Although the occurrence of exogenous factors, such as extreme weather and fires, can have a significant influence on the fragmentation of the territory in time and space, the accelerated development of the built environment (+470%) is nevertheless found to be primarily responsible for landscape fragmentation and the loss of areas formerly occupied by orchards, agriculture, and woodlands. The landscape metrics used corroborate these results, with a simplification of the shape of polygons, and once again reveal the difficulties of harmonizing different land uses. MSH has become somewhat of a forest island in a sea of residential development and agriculture. To counter this isolation of fragmented habitat components, forest corridors have been proposed and developed for the Biosphere Reserve and particularly for the core area. Two corridors, to the north and south, are used to connect the protected area and other wooded areas at the regional scale, in order to promote genetic exchange between populations of various species. In that regard, the forest buffer zone around the hill continues to play a key role and has great ecological value for species and ecological preservation and conservation. However, appropriate management and landscape preservation actions should recognize and focus on landscape composition and the associated geographical configuration.

  10. Assessing the Goodness of Fit of Phylogenetic Comparative Methods: A Meta-Analysis and Simulation Study: e67001

    National Research Council Canada - National Science Library

    Dwueng-Chwuan Jhwueng

    2013-01-01

    ...? Data I conducted a meta-analysis of 122 phylogenetic data sets found by searching all papers in JEB, Blackwell Synergy and JSTOR published in 2002-2005 for the purpose of assessing the fit of PCMs...

  11. Enteric disease surveillance under the AFHSC-GEIS: Current efforts, landscape analysis and vision forward

    Directory of Open Access Journals (Sweden)

    Kasper Matthew R

    2011-03-01

    Full Text Available Abstract The mission of the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS is to support global public health and to counter infectious disease threats to the United States Armed Forces, including newly identified agents or those increasing in incidence. Enteric diseases are a growing threat to U.S. forces, which must be ready to deploy to austere environments where the risk of exposure to enteropathogens may be significant and where routine prevention efforts may be impractical. In this report, the authors review the recent activities of AFHSC-GEIS partner laboratories in regards to enteric disease surveillance, prevention and response. Each partner identified recent accomplishments, including support for regional networks. AFHSC/GEIS partners also completed a Strengths, Weaknesses, Opportunities and Threats (SWOT survey as part of a landscape analysis of global enteric surveillance efforts. The current strengths of this network include excellent laboratory infrastructure, equipment and personnel that provide the opportunity for high-quality epidemiological studies and test platforms for point-of-care diagnostics. Weaknesses include inconsistent guidance and a splintered reporting system that hampers the comparison of data across regions or longitudinally. The newly chartered Enterics Surveillance Steering Committee (ESSC is intended to provide clear mission guidance, a structured project review process, and central data management and analysis in support of rationally directed enteric disease surveillance efforts.

  12. Enteric disease surveillance under the AFHSC-GEIS: current efforts, landscape analysis and vision forward.

    Science.gov (United States)

    Money, Nisha N; Maves, Ryan C; Sebeny, Peter; Kasper, Matthew R; Riddle, Mark S; Wu, Max; Lee, James E; Schnabel, David; Bowden, Robert; Oaks, Edwin V; Ocaña, Victor; Acosta, Luis; Gotuzzo, Eduardo; Lanata, Claudio; Ochoa, Theresa; Aguayo, Nicolás; Bernal, Maruja; Meza, Rina; Canal, Enrique; Gregory, Michael; Cepeda, David; Listiyaningsih, Erlin; Putnam, Shannon D; Young, Sylvia; Mansour, Adel; Nakhla, Isabelle; Moustafa, Manal; Hassan, Khaled; Klena, John; Bruton, Jody; Shaheen, Hind; Farid, Sami; Fouad, Salwa; El-Mohamady, Hanan; Styles, Timothy; Shiau, L C D R Danny; Espinosa, Benjamin; McMullen, Kellie; Reed, Eva; Neil, Donald; Searles, Doug; Nevin, Remington; Von Thun, Annette; Sessions, Cecili

    2011-03-04

    The mission of the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) is to support global public health and to counter infectious disease threats to the United States Armed Forces, including newly identified agents or those increasing in incidence. Enteric diseases are a growing threat to U.S. forces, which must be ready to deploy to austere environments where the risk of exposure to enteropathogens may be significant and where routine prevention efforts may be impractical. In this report, the authors review the recent activities of AFHSC-GEIS partner laboratories in regards to enteric disease surveillance, prevention and response. Each partner identified recent accomplishments, including support for regional networks. AFHSC/GEIS partners also completed a Strengths, Weaknesses, Opportunities and Threats (SWOT) survey as part of a landscape analysis of global enteric surveillance efforts. The current strengths of this network include excellent laboratory infrastructure, equipment and personnel that provide the opportunity for high-quality epidemiological studies and test platforms for point-of-care diagnostics. Weaknesses include inconsistent guidance and a splintered reporting system that hampers the comparison of data across regions or longitudinally. The newly chartered Enterics Surveillance Steering Committee (ESSC) is intended to provide clear mission guidance, a structured project review process, and central data management and analysis in support of rationally directed enteric disease surveillance efforts.

  13. Landscape evolution reconstructions on Mars: a detailed analysis of lacustrine and fluvial terraces

    Science.gov (United States)

    Rossato, Sandro; Pajola, Maurizio; Baratti, Emanuele; Mangili, Clara; Coradini, Marcello

    2015-04-01

    Liquid water was flowing on the surface of Mars in the past, leaving behind a wide range of geomorphic features. The ancient major Martian water fluxes vanished about 3.5 Ga. Meteoritic impacts, wind-erosion, gravity-related phenomena, tectonic deformations and volcanic activities deeply altered the landforms during the ages. Hence, the reconstruction of water-shaped landscapes is often complicated. Fluvial and lacustrine terraces analysis and correlation is a useful approach to understand and reconstruct the past changes in Martian landscape evolution. These features are commonly used as reference for the top of water bodies on Earth, since they are void of the uncertainties or errors deriving from erosional or slumping processes that could have acted on the valley flanks or in the plateau, where the hydrological network was carved in. The study area is located in the western hemisphere of Mars, in the Memnonia quadrangle, between latitude 9° 10'-9° 50'South and longitude 167° 0'-167° 30' West and it constitutes a transition region between the southern highlands of Terra Sirenum and the northern lowlands of Lucus Planum. Many water-shaped features have already been described near the study area, the most prominent of them being the Ma'adim Vallis and the Mangala Valles system. Our results derive from the observations and the analysis of HRSC images (12.5 m spatial resolution) and Digital Elevation Models (DEMs) derived from the MEX-HRSC (75 m resolution), that allow the identification of elevation differences up to the tens of meter scale. We were able to reconstruct six main evolutionary stages of a complex hydrologic systems consisting of two main palaeorivers (up to 5 km wide) connected one another by a palaeolake that formed within a meteor crater (~20 km diameter). On the basis of Earth analogs, these stages/terraces should have evolved during a long period of time, at least thousands years long. Furthermore, crater counting date back the deactivation of

  14. 康复性景观及其相关概念辨析%Analysis of the Healing Landscape and Its Relevant Conceptions

    Institute of Scientific and Technical Information of China (English)

    王晓博; 李金凤

    2012-01-01

    通过介绍康复性景观基本概念及相关名词,分析康复性景观的特点,同时对康复性景观与一般性景观进行比较分析,并且将康复性景观与园艺疗法、景观疗法的概念及其之间的关系进行辨析,试图理清康复性景观的内涵和外延.%As more and more studies on healing landscape appeared, the analysis of the conception of healing landscape became necessary. This paper introduced the basic conception of healing landscape and its related nouns, and analysed the features of healing landscape. The differences between healing Landscape and general landscape, and the relationship among healing landscape and horticultural therapy, landscape therapy were discussed in the essay. The clearness of the connotation and extension of healing landscape was helpful for the future study on this field.

  15. Visibility Analysis of the Oriental Pearl Based on Digital Landscape Simulation - View from East Daming Road of Shanghai

    Science.gov (United States)

    Liu, S.; Zhang, S.

    2015-08-01

    As the demand for visual quality of environment increases, visual analysis therefore plays progressively important role in current urban landscape construction and management. Guided by the City Image theory, this paper presents a covered scene index "X" to describe the visibility of the target scene, and formulates a digital analysis model based on ArcGIS and 3D simulation. This method is applied to the viewpoint analysis from the East Daming Road of the North Bund to the Oriental Pearl in Shanghai and optimized solutions are proposed according to the results. It turns out that this simple and objective technique can serve as a good tool for the reference of urban landscape planning and management.

  16. The analysis of the landscape resources and Xiamen botanical garden landscape construction%浅析厦门植物园景观资源与景观营造

    Institute of Scientific and Technical Information of China (English)

    颜佩楠

    2012-01-01

    The function of the botanical garden and the connotation with the continuous development of society and rich and expansion.This article from the historical evolution,landscape resources and basic conditions on Xiamen botanical garden is analyzed,and its ecological science,history introduced humanities,natural resources and leisure fitness four types of landscape construction,so as to modern botanical garden for planning design goal of innovation,so as to realize the scientific nature,the landscape sex,the unity of the educational goal to build for different types of landscape,has certain practical significance.%植物园的功能和内涵随着社会的不断发展而丰富和拓展。该文从历史沿革、景观资源及基础条件对厦门植物园进行分析,介绍其生态科普、历史人文、自然资源和休闲健身四个类型的景观营造等,以现代植物园为规划设计目标进行创新,以实现科学性、景观性、教育性的统一性为目标来营造不同类型的景观,具有一定的实践指导意义。

  17. An analysis of weight loss articles and advertisements inmainstream women’s health and fitness magazines

    National Research Council Canada - National Science Library

    Danna Ethan; Corey Basch; Grace Hillyer; Alyssa Berdnik; Mary Huynh

    2016-01-01

    ... women’s health and fitness magazines. Methods: This preliminary cross-sectional study evaluated the prevalence of articles and advertisements featuring weight loss content and products in mainstream US-based health and fitness magazines, as well...

  18. Constraining processes of landscape change with combined in situ cosmogenic 14C-10Be analysis

    Science.gov (United States)

    Hippe, Kristina

    2017-10-01

    Reconstructing Quaternary landscape evolution today frequently builds upon cosmogenic-nuclide surface exposure dating. However, the study of complex surface exposure chronologies on the 102-104 years' timescale remains challenging with the commonly used long-lived radionuclides (10Be, 26Al, 36Cl). In glacial settings, key points are the inheritance of nuclides accumulated in a rock surface during a previous exposure episode and (partial) shielding of a rock surface after the main deglaciation event, e.g. during phases of glacier readvance. Combining the short-lived in situ cosmogenic 14C isotope with 10Be dating provides a valuable approach to resolve and quantify complex exposure histories and burial episodes within Lateglacial and Holocene timescales. The first studies applying the in situ14C-10Be pair have demonstrated the great benefit from in situ14C analysis for unravelling complex glacier chronologies in various glacial environments worldwide. Moreover, emerging research on in situ14C in sedimentary systems highlights the capacity of combined in situ14C-10Be analysis to quantify sediment transfer times in fluvial catchments or to constrain changes in surface erosion rates. Nevertheless, further methodological advances are needed to obtain truly routine and widely available in situ14C analysis. Future development in analytical techniques has to focus on improving the analytical reproducibility, reducing the background level and determining more accurate muonic production rates. These improvements should allow extending the field of applications for combined in situ14C-10Be analysis in Earth surface sciences and open up a number of promising applications for dating young sedimentary deposits and the quantification of recent changes in surface erosion dynamics.

  19. Landscape morphology metrics for urban areas: analysis of the role of vegetation in the management of the quality of urban environment

    Directory of Open Access Journals (Sweden)

    Danilo Marques de Magalhães

    2013-05-01

    Full Text Available This study has the objective to demonstrate the applicability of landscape metric analysis undertaken in fragments of urban land use. More specifically, it focuses in low vegetation cover, arboreal and shrubbery vegetation and their distribution on land use. Differences of vegetation cover in dense urban areas are explained. It also discusses briefly the state-of-the-art Landscape Ecology and landscape metrics. It develops, as an example, a case study in Belo Horizonte, Minas Gerais, Brazil. For this study, it selects the use of the area’s metrics, the relation between area, perimeter, core, and circumscribed circle. From this analysis, this paper proposes the definition of priority areas for conservation, urban parks, free spaces of common land, linear parks and green corridors. It is demonstrated that, in order to design urban landscape, studies of two-dimension landscape representations are still interesting, but should consider the systemic relation between different factors related to shape and land use.

  20. Descriptive analysis of the type and design of contact lenses fitted according to keratoconus severity and morphology

    Directory of Open Access Journals (Sweden)

    Letícia Helena Lunardi

    2016-04-01

    Full Text Available ABSTRACT Purpose: Keratoconus is characterized by bilateral asymmetrical corneal ectasia that leads to inferior stromal thinning and corneal protrusion. There is currently a lack of consensus regarding the most efficacious method for fitting contact lenses in patients with keratoconus, given the various topographical patterns and evolution grades observed in affected populations. The purpose of the present study was to evaluate the association between keratoconus evolution grade and topography pattern and the type and design of fitted contact lens. Methods: We performed a retrospective analysis of contact lenses fitted in a total of 185 patients with keratoconus (325 eyes. Keratoconus was classified as either grade I, II, III, or IV based on keratometry and cone morphology (nipple, oval, globus, or indeterminate results. Results: A total of 325 eyes were evaluated in the present study. Of the 62 eyes classified as grade I, 66.1% were fitted with monocurve contact lenses. Of the 162 eyes classified as grade I and II, 51%, 30%, and 19% were fitted with adapted monocurve rigid gas-permeable contact lenses (RGPCL, bicurve lenses, and others lens types, respectively. Bicurve lenses were fitted in 52.1% and 62.2% of eyes classified as grade III and IV, respectively. Of the eyes classified as grade III and IV, monocurve and bicurve RGPCL were fitted in 26% and 55%, respectively. In eyes with oval keratoconus, 45%, 35%, and 20% were fitted with monocurve lenses, bicurve lenses, and other lens types, respectively. In eyes with round cones (nipple morphology, 55%, 30%, and 15% were fitted with bicurve lenses, monocurve lenses, and other lens types, respectively. Conclusion: Monocurve RGPCL were most frequently fitted in patients with mild to moderate keratoconus and oval cones morphology, while bicurve lenses were more frequently fitted in patients with severe and advanced keratoconus. This was probably because bicurve lenses are more appropriate for

  1. ZonalMetrics - a Python toolbox for zonal landscape structure analysis

    Science.gov (United States)

    Adamczyk, Joanna; Tiede, Dirk

    2017-02-01

    We present a Python toolbox for the calculation of zonal landscape metrics. Instead of global calculations focusing on the whole landscape, the proposed ZonalMetrics toolbox allows the calculation of landscape metrics for user-defined zones. Such zones can be defined through regular units (e.g. hexagons, grids) that can be created within the toolbox. In addition, any polygonal set specified by the user (e.g. administrative units) can be used. The implemented set of landscape metrics is specifically selected and valid for calculations within zones. The tool is demonstrated based on a case study for the Warsaw metropolitan area and the possibilities of applying the toolbox for different zonal layers are illustrated. The implementation is based on the Python toolbox introduced in ArcGIS 10.1, offering an easy to use graphical user interface and batch calculation possibilities. The source code is free and open to the community and extendable to specific needs.

  2. Towards climate reconstruction on Mars using landscape analysis: Insights from terrestrial analogues

    Science.gov (United States)

    Hauber, E.; Ulrich, M.; Reiss, D.; Hiesinger, H.; Balme, M. R.; Gallagher, C. J.

    2011-12-01

    Many very young landforms on Mars resemble terrestrial glacial and periglacial surface features in permafrost regions and show a latitude-dependent geographic distribution. They include surface mantling, viscous flow features, polygonally fractured ground, patterned ground, fractured mounds, and gullies. Collectively, these landforms are hypothesized to represent the geomorphological surface record of Martian ice ages that were triggered by astronomical forcing and associated climate changes. Many previous studies of possible cold-climate features on Mars considered just one of them in isolation, e.g., polygons or fractured mounds. Such approaches do not consider the geomorphologic context of the landforms, and thus interpretations can be ambiguous due to the possible effect of equifinality. A more comprehensive investigation of the full assemblage of associated landforms (landscape analysis) has the potential to reduce this ambiguity. We use the permafrost landscape of Spitsbergen (Svalbard, Norway) as an analogue for the assemblage of cold-climate landforms that is typically found in mid-latitudes on Mars. Although relatively warm and wet as compared to other cold-climate analogues on Earth, Spitsbergen is a particularly instructive morphological analogue to Mars as it offers many surface features in a close spatial context that are strikingly similar to those on Mars. Based on this comparison, which uses remote sensing and field data from Svalbard, we identify similarities as well as differences, both of which are important in the use of analogues as a means to establish testable hypotheses. We then propose possible scenarios which may help to understand the evolution of Martian landforms into their present state. Of particular interest with respect to the habitability of Martian permafrost is whether liquid water was involved or not. Most phenomena on Mars, but not Svalbard, can plausibly be explained by "dry" permafrost scenarios without the need to invoke

  3. Analysis of colors used on outdoor advertising in urban landscape: a case study in Osaka city

    Science.gov (United States)

    Takahashi, Mika; Fujibayashi, Kazumi; Shimonaka, Tomomi; Sato, Masako; Sawa, Kazuhiro

    2002-06-01

    This is a case study for practical survey and assessment of urban landscapes containing outdoor advertisements in Osaka City, Japan. We practically surveyed and analyzed the colors used on the outdoor advertisements in the three urban areas: the business area long the main street, the amusement area along the shopping street, and the station plaza in front of the railroad terminal. Further by the laboratory experiments, we examined the interrelation between the atmosphere of the area and the impression arising from the outdoor advertisements using the pictures of street scenes on video monitor. In this experiment, eye movements of each subject observing the scene were analyzed by eye point recorder. (1) In general, vivid red, yellow, green and blue, and white and black were frequently used on the outdoor advertisements in every area. (2) The character of each area was respectively found out by analysis of the following factors: the type of advertisement, the size of each advertisement, and the arrangement of the advertisements. Vivid colors on the outdoor advertisements could be clearly perceived even from a distance. Then, our eyes would be attracted by vivid colors of them. (4) The atmosphere of the area would be affected by favorable or unfavorable impression from the outdoor advertisements. For instance, on the main street, the advertisements would impress us favorably if they are in harmony with each other and create an orderly and elegant streetscape. On the shopping street, various advertisements would impress us favorably if they create a lively and cheerful streetscape.

  4. The Changing Financial Landscape of Renal Transplant Practice: A National Cohort Analysis.

    Science.gov (United States)

    Axelrod, D A; Schnitzler, M A; Xiao, H; Naik, A S; Segev, D L; Dharnidharka, V R; Brennan, D C; Lentine, K L

    2017-02-01

    Kidney transplantation has become more resource intensive as recipient complexity has increased and average donor quality has diminished over time. A national retrospective cohort study was performed to assess the impact of kidney donor and recipient characteristics on transplant center cost (exclusive of organ acquisition) and Medicare reimbursement. Data from the national transplant registry, University HealthSystem Consortium hospital costs, and Medicare payments for deceased donor (N = 53 862) and living donor (N = 36 715) transplants from 2002 to 2013 were linked and analyzed using multivariate linear regression modeling. Deceased donor kidney transplant costs were correlated with recipient (Expected Post Transplant Survival Score, degree of allosensitization, obesity, cause of renal failure), donor (age, cause of death, donation after cardiac death, terminal creatinine), and transplant (histocompatibility matching) characteristics. Living donor costs rose sharply with higher degrees of allosensitization, and were also associated with obesity, cause of renal failure, recipient work status, and 0-ABDR mismatching. Analysis of Medicare payments for a subsample of 24 809 transplants demonstrated minimal correlation with patient and donor characteristics. In conclusion, the complexity in the landscape of kidney transplantation increases center costs, posing financial disincentives that may reduce organ utilization and limit access for higher-risk populations.

  5. Free energy landscape of the Michaelis complex of lactate dehydrogenase: A network analysis of atomistic simulations

    Science.gov (United States)

    Pan, Xiaoliang; Schwartz, Steven

    2015-03-01

    It has long been recognized that the structure of a protein is a hierarchy of conformations interconverting on multiple time scales. However, the conformational heterogeneity is rarely considered in the context of enzymatic catalysis in which the reactant is usually represented by a single conformation of the enzyme/substrate complex. Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of two forms of the cofactor nicotinamide adenine dinucleotide (NADH and NAD+). Recent experimental results suggest that multiple substates exist within the Michaelis complex of LDH, and they are catalytic competent at different reaction rates. In this study, millisecond-scale all-atom molecular dynamics simulations were performed on LDH to explore the free energy landscape of the Michaelis complex, and network analysis was used to characterize the distribution of the conformations. Our results provide a detailed view of the kinetic network the Michaelis complex and the structures of the substates at atomistic scale. It also shed some light on understanding the complete picture of the catalytic mechanism of LDH.

  6. Stratigraphic landscape analysis, thermochronology and the episodic development of elevated, passive continental margins

    Directory of Open Access Journals (Sweden)

    Green, Paul F.

    2013-12-01

    Full Text Available The continental margin of West Greenland is similar in many respects to other elevated, passive continental margins (EPCMs around the world. These margins are characterised by extensive regions of low relief at elevations of 1–2 kilometres above sea level sloping gently inland, with a much steeper, oceanward decline, often termed a 'Great Escarpment', terminating at a coastal plain. Recent studies, based on integration of geological, geomorphological and thermochronological evidence, have shown that the high topography of West Greenland was formed by differential uplift and dissection of an Oligo-Miocene peneplain since the late Miocene, many millions of years after continental break-up between Greenland and North America. In contrast, many studies of other EPCMs have proposed a different style of development in which the high plateaux and the steep, oceanward decline are regarded as a direct result of rifting and continental separation. Some studies assume that the elevated regions have remained high since break-up, with the high topography continuously renewed by isostasy. Others identify the elevated plains as remnants of pre-rift landscapes. Key to understanding the development of the West Greenland margin is a new approach to the study of landforms, stratigraphic landscape analysis, in which the low-relief, high-elevation plateaux at EPCMs are interpreted as uplifted peneplains: low-relief surfaces of large extent, cutting across bedrock of different age and resistance, and originally graded to sea level. Identification of different generations of peneplain (re-exposed and epigene from regional mapping, combined with geological constraints and thermochronology, allows definition of the evolution leading to the formation of the modern-day topography. This approach is founded particularly on results from the South Swedish Dome, which document former sea levels as base levels for the formation of peneplains. These results support the view

  7. Self-similarity in a General Aggregation-Fragmentation Problem ; Application to Fitness Analysis

    CERN Document Server

    Calvez, Vincent; Gabriel, Pierre

    2010-01-01

    We consider the linear growth and fragmentation equation with general coefficients. Under suitable conditions, the first eigenvalue represents the asymptotic growth rate of solutions, also called \\emph{fitness} or \\emph{Malthus coefficient} in population dynamics ; it is of crucial importance to understand the long-time behaviour of the population. We investigate the dependency of the dominant eigenvalue and the corresponding eigenvector on the transport and fragmentation coefficients. We show how it behaves asymptotically as transport dominates fragmentation or \\emph{vice versa}. For this purpose we perform suitable blow-up analysis of the eigenvalue problem in the limit of small/large growth coefficient (resp. fragmentation coefficient). We exhibit possible non-monotonic dependency on the parameters, conversely to what would have been conjectured on the basis of some simple cases.

  8. An empirical analysis of the quantitative effect of data when fitting quadratic and cubic polynomials

    Science.gov (United States)

    Canavos, G. C.

    1974-01-01

    A study is made of the extent to which the size of the sample affects the accuracy of a quadratic or a cubic polynomial approximation of an experimentally observed quantity, and the trend with regard to improvement in the accuracy of the approximation as a function of sample size is established. The task is made possible through a simulated analysis carried out by the Monte Carlo method in which data are simulated by using several transcendental or algebraic functions as models. Contaminated data of varying amounts are fitted to either quadratic or cubic polynomials, and the behavior of the mean-squared error of the residual variance is determined as a function of sample size. Results indicate that the effect of the size of the sample is significant only for relatively small sizes and diminishes drastically for moderate and large amounts of experimental data.

  9. Analysis of surface soil moisture patterns in agricultural landscapes using empirical orthogonal functions

    Directory of Open Access Journals (Sweden)

    W. Korres

    2009-08-01

    Full Text Available Soil moisture is one of the fundamental variables in hydrology, meteorology and agriculture. Nevertheless, its spatio-temporal patterns in agriculturally used landscapes affected by multiple natural (rainfall, soil, topography etc. and agronomic (fertilisation, soil management etc. factors are often not well known. The aim of this study is to determine the dominant factors governing the spatio-temporal patterns of surface soil moisture in a grassland and an arable land test site within the Rur catchment in Western Germany. Surface soil moisture (0–6 cm has been measured in an approx. 50×50 m grid at 14 and 17 dates (May 2007 to November 2008 in both test sites. To analyse spatio-temporal patterns of surface soil moisture, an Empirical Orthogonal Function (EOF analysis was applied and the results were correlated with parameters derived from topography, soil, vegetation and land management to connect the pattern to related factors and processes. For the grassland test site, the analysis results in one significant spatial structure (first EOF, which explains about 57.5% of the spatial variability connected to soil properties and topography. The weight of the first spatial EOF is stronger on wet days. The highest temporal variability can be found in locations with a high percentage of soil organic carbon (SOC. For the arable land test site, the analysis yields two significant spatial structures, the first EOF, explaining 38.4% of the spatial variability, shows a highly significant correlation to soil properties, namely soil texture. The second EOF, explaining 28.3% of the spatial variability, is connected to differences in land management. The soil moisture in the arable land test site varies more during dry and wet periods on locations with low porosity.

  10. Drainage basin and topographic analysis of a tropical landscape: Insights into surface and tectonic processes in northern Borneo

    Science.gov (United States)

    Mathew, Manoj Joseph; Menier, David; Siddiqui, Numair; Ramkumar, Mu.; Santosh, M.; Kumar, Shashi; Hassaan, Muhammad

    2016-07-01

    We investigated the recent landscape development of Borneo through geomorphic analysis of two large drainage basins (Rajang and Baram basins). The extraction of morphometric parameters utilizing digital terrain data in a GIS environment, focusing on hydrography (stream length-gradient index, ratio of valley floor width to valley height, and transverse topographic symmetry factor) and topography (local relief and relief anomaly), was carried out in order to elucidate processes governing drainage and landscape evolution. Anomalously high and low values of stream length-gradient indices of main tributary streams associated with faults and multiple knick-points along the channel profiles are linked to deformation events. The development of deeply incised V-shaped valleys show enhanced incision capability of streams in response to steepening of hillslope gradients following tectonic inputs. Deflection of streams and probable dynamic reorganization of the drainage system through stream capture processes as feedbacks to tectonic uplift and orographic effect are observed. Local relief and relief anomaly maps highlight the presence of preserved elevation-accordant relict portions of landscapes characterized by low amplitude relief, nested between ridgelines in regions of complex folding. Our results reveal dynamic geomorphic adjustment of the landscape due to perturbations in tectonic and climatic boundary conditions. The implication is that the landscape of north Borneo experienced a tectonic phase of rapid uplift after 5 Ma and undergoes active folding of the Rajang Group thrust belts in the present-day. Active shortening combined with high rates of denudation in Sarawak, demonstrates transience emphasized by the drainage system attempting to adjust to tectonic and climatic forcing.

  11. TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays

    Directory of Open Access Journals (Sweden)

    Xie Dan

    2007-04-01

    Full Text Available Abstract Background A nearly complete collection of gene-deletion mutants (96% of annotated open reading frames of the yeast Saccharomyces cerevisiae has been systematically constructed. Tag microarrays are widely used to measure the fitness of each mutant in a mutant mixture. The tag array experiments can have a complex experimental design, such as time course measurements and drug treatment with multiple dosages. Results TagSmart is a web application for analysis and visualization of Saccharomyces cerevisiae mutant fitness data measured by tag microarrays. It implements a robust statistical approach to assess the concentration differences among S. cerevisiae mutant strains. It also provides an interactive environment for data analysis and visualization. TagSmart has the following advantages over previously described analysis procedures: 1 it is user-friendly software rather than merely a description of analytical procedure; 2 It can handle complicated experimental designs, such as multiple time points and treatment with multiple dosages; 3 it has higher sensitivity and specificity; 4 It allows users to mask out "bad" tags in the analysis. Two biological tests were performed to illustrate the performance of TagSmart. First, we generated titration mixtures of mutant strains, in which the relative concentration of each strain was controlled. We used tag microarrays to measure the numbers of tag copies in each titration mixture. The data was analyzed with TagSmart and the result showed high precision and recall. Second, TagSmart was applied to a dataset in which heterozygous deletion strain mixture pools were treated with a new drug, Cincreasin. TagSmart identified 53 mutant strains as sensitive to Cincreasin treatment. We individually tested each identified mutant, and found 52 out of the 53 predicted mutants were indeed sensitive to Cincreasin. Conclusion TagSmart is provided "as is" to analyze tag array data produced by Affymetrix and Agilent

  12. [Application of land economic ecological niche in landscape pattern analysis at county level: A case study of Jinghe County in Xinjiang, China].

    Science.gov (United States)

    Yu, Hai-yang; Zhang, Fei; Wang, Juan; Zhou, Mei

    2015-12-01

    The theory of land economic ecological niche was used to analyze the regional landscape pattern in this article, with an aim to provide a new method for the characterization and representation of landscape pattern. The Jinghe County region, which is ecologically fragile, was selected as an example for the study, and the Landsat images of 1990, 1998, 2011 and 2013 were selected as remote sensing data. The land economic ecological niche of land use types calculated by ecostate-ecorole theory, combined with landscape ecology theory, was discussed in application of land economic ecological niche in county landscape pattern analysis. The results showed that, during the study period, the correlations between land economic ecological niche of farmland, construction land, and grassland with the parameters, including landscape patch number (NP), aggregated index (AI), fragmented index (FN) and fractal dimension (FD), were significant. Regional landscape was driven by the changes of land economic ecological niche, and the trend of economic development could be represented by land economic ecological niche change in Jinghe County. Land economic ecological niche was closely related with the land use types which could yield direct economic benefits, which could well explain the landscape pattern characteristics in Jinghe County when combined with the landscape indices.

  13. Biodiversity research trends and gap analysis from a transboundary landscape, Eastern Himalayas

    Directory of Open Access Journals (Sweden)

    Pratikshya Kandel

    2016-03-01

    Full Text Available The Kangchenjunga landscape, a transboundary complex shared by Bhutan, India, and Nepal, is one of the biologically richest regions in the Eastern Himalayas. Owing to the remarkable biodiversity, the three countries came together to enhance regional cooperation in conservation and development in 2012. To start a strategic conservation intervention, the status of our knowledge base on biodiversity of the landscape is the most important stepping stone. In this paper, we traced the history of biodiversity research in the Kangchenjunga landscape, and present the research trends over time and subject interests. Meanwhile, we also identified key research and knowledge gaps and future priorities. For this, we analyzed 500 peer-reviewed journal articles (until 2014 relating to biodiversity, which were retrieved from the web platform ‘Google Scholar’ and other peer-reviewed journals. The review showed that the landscape received attention from the scientific community as early as the 1840s, and grew progressively after the 1980s. Research on fauna (especially mammals and flora (especially angiosperms is most notable, but with major gaps in systematic research of their ecology, whereas invertebrates other than butterflies appear to be neglected. There is a need for systematic research with long-term monitoring that would allow us to understand changes occurring within the landscape.

  14. Analysis of Nuclear Power Plant Fittings Stock Management and Design of a Decision Support System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Through analyzing the desired characteristics of fittings in a nuclear power plant, the representative random stock models are built, and forecast methods about the desired probability of fittings are discussed secondly, the design of the plant fittings stock decision support system (FSDSS) is given.Then the main features of this system and function modules are introduced, and the special emphasis on organization of a database and composition and memory of a model base is given.

  15. Analysis of physical fitness and coronary heart disease risk of Dallas area police officers.

    Science.gov (United States)

    Pollock, M L; Gettman, L R; Meyer, B U

    1978-06-01

    Two hundred thirteen male police officers between 21 and 52 years of age volunteered to participate in a physical evaluation and conditioning program. Information concerning the physical fitness status and risk of coronary heart disease (CHD) of police officers were shown. Younger police officers (less than 30 years of age) were average in physical fitness levels and CHD risk compared to the population of the same age. Middle-aged police officers were shown to be lower in physical fitness levels and higher in CHD risk compared to their cohorts. The results from this investigation support the need for physical fitness and preventive medicine programs for police officers.

  16. FIT ANALYSIS OF INDOSAT DOMPETKU BUSINESS MODEL USING A STRATEGIC DIAGNOSIS APPROACH

    Directory of Open Access Journals (Sweden)

    Fauzi Ridwansyah

    2015-09-01

    Full Text Available Mobile payment is an industry's response to global and regional technological-driven, as well as national social-economical driven in less cash society development. The purposes of this study were 1 identifying positioning of PT. Indosat in providing a response to Indonesian mobile payment market, 2 analyzing Indosat’s internal capabilities and business model fit with environment turbulence, and 3 formulating the optimum mobile payment business model development design for Indosat. The method used in this study was a combination of qualitative and quantitative analysis through in-depth interviews with purposive judgment sampling. The analysis tools used in this study were Business Model Canvas (MBC and Ansoff’s Strategic Diagnosis. The interviewees were the representatives of PT. Indosat internal management and mobile payment business value chain stakeholders. Based on BMC mapping which is then analyzed by strategic diagnosis model, a considerable gap (>1 between the current market environment and Indosat strategy of aggressiveness with the expected future of environment turbulence level was obtained. Therefore, changes in the competitive strategy that need to be conducted include 1 developing a new customer segment, 2 shifting the value proposition that leads to the extensification of mobile payment, 3 monetizing effective value proposition, and 4 integrating effective collaboration for harmonizing company’s objective with the government's vision. Keywords: business model canvas, Indosat, mobile payment, less cash society, strategic diagnosis

  17. Assessments of habitat preferences and quality depend on spatial scale and metrics of fitness

    Science.gov (United States)

    Chalfoun, A.D.; Martin, T.E.

    2007-01-01

    1. Identifying the habitat features that influence habitat selection and enhance fitness is critical for effective management. Ecological theory predicts that habitat choices should be adaptive, such that fitness is enhanced in preferred habitats. However, studies often report mismatches between habitat preferences and fitness consequences across a wide variety of taxa based on a single spatial scale and/or a single fitness component. 2. We examined whether habitat preferences of a declining shrub steppe songbird, the Brewer's sparrow Spizella breweri, were adaptive when multiple reproductive fitness components and spatial scales (landscape, territory and nest patch) were considered. 3. We found that birds settled earlier and in higher densities, together suggesting preference, in landscapes with greater shrub cover and height. Yet nest success was not higher in these landscapes; nest success was primarily determined by nest predation rates. Thus landscape preferences did not match nest predation risk. Instead, nestling mass and the number of nesting attempts per pair increased in preferred landscapes, raising the possibility that landscapes were chosen on the basis of food availability rather than safe nest sites. 4. At smaller spatial scales (territory and nest patch), birds preferred different habitat features (i.e. density of potential nest shrubs) that reduced nest predation risk and allowed greater season-long reproductive success. 5. Synthesis and applications. Habitat preferences reflect the integration of multiple environmental factors across multiple spatial scales, and individuals may have more than one option for optimizing fitness via habitat selection strategies. Assessments of habitat quality for management prescriptions should ideally include analysis of diverse fitness consequences across multiple ecologically relevant spatial scales. ?? 2007 The Authors.

  18. Quasispecies on Class-Dependent Fitness Landscapes.

    Science.gov (United States)

    Cerf, Raphaël; Dalmau, Joseba

    2016-06-01

    We study Eigen's quasispecies model in the asymptotic regime where the length of the genotypes goes to [Formula: see text] and the mutation probability goes to 0. We give several explicit formulas for the stationary solutions of the limiting system of differential equations.

  19. Association of Physical Fitness With the Risk of Atrial Fibrillation: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Zhu, Wengen; Shen, Yang; Zhou, Qiongqiong; Xu, Zhenyan; Huang, Lin; Chen, Qi; Hong, Kui

    2016-07-01

    Several studies have investigated the role of physical fitness in atrial fibrillation (AF), but the results remain controversial. We aimed to estimate the association between physical fitness and risk of AF. We comprehensively retrieved data from the Cochrane Library, PubMed, and Embase databases until February 29, 2016, for studies evaluating the association of physical fitness with the risk of AF. Data were abstracted from included studies, and effect estimates were pooled using a random-effects model. Six studies with a total of 205 094 participants and 15 919 AF cases fulfilled the inclusion criteria. When physical fitness was assessed as a continuous variable, per incremental increase of physical fitness was associated with a 9% reduced risk of AF (risk ratio [RR]: 0.91, 95% confidence interval [CI]: 0.84-1.00, P = 0.05). When physical fitness was assessed as a categorical variable, the risk of AF was significantly reduced (RR: 0.51, 95% CI: 0.28-0.91, P = 0.02) in individuals with the highest level of physical fitness compared with those with the lowest level. The intermediate vs the lowest level of physical fitness was associated with a 28% reduced risk of AF (RR: 0.72, 95% CI: 0.56-0.93, P = 0.01). The sensitivity analysis indicated that these results were stable. Notably, there was evidence of statistical heterogeneity across studies; therefore, we should interpret the results cautiously. In conclusion, published literature supports that a higher level of physical fitness is associated with a lower risk of AF. Further studies should be performed to confirm these findings.

  20. [Landscape and ecological genomics].

    Science.gov (United States)

    Tetushkin, E Ia

    2013-10-01

    Landscape genomics is the modern version of landscape genetics, a discipline that arose approximately 10 years ago as a combination of population genetics, landscape ecology, and spatial statistics. It studies the effects of environmental variables on gene flow and other microevolutionary processes that determine genetic connectivity and variations in populations. In contrast to population genetics, it operates at the level of individual specimens rather than at the level of population samples. Another important difference between landscape genetics and genomics and population genetics is that, in the former, the analysis of gene flow and local adaptations takes quantitative account of landforms and features of the matrix, i.e., hostile spaces that separate species habitats. Landscape genomics is a part of population ecogenomics, which, along with community genomics, is a major part of ecological genomics. One of the principal purposes of landscape genomics is the identification and differentiation of various genome-wide and locus-specific effects. The approaches and computation tools developed for combined analysis of genomic and landscape variables make it possible to detect adaptation-related genome fragments, which facilitates the planning of conservation efforts and the prediction of species' fate in response to expected changes in the environment.

  1. Analysis of SAR and optical temporal signatures of grapevine over a heterogeneous vineyard landscape

    Science.gov (United States)

    Loussert, P.; Baup, F.; Corgne, S.; Quénol, H.; Ortega, A.

    2016-10-01

    The aim of this work is to analyse grapevine temporal signatures over a viticultural landscape with remote sensing data in order to evaluate the impact of the perennial practices on optical and SAR signals. For this, the effects of different combinations of vineyard organisations on multi-temporal high and very high spatial resolution SAR and optical data have been analysed. The study area is located in Mendoza (Argentina). All the ground data were acquired during an experimental campaign performed in 2014-2015 over 153 vineyards (around 400ha). The data of the perennial practices were recorded over each of the 153 vineyards. The schedule of the annual practices were also provided over the all site. The grapevine phenological cycle was finally monitored on 14 fields through GLAI (Green Leaf Area index) estimation using hemispherical images and grapevine canopy height measurements. The satellite images dataset is composed of 6 Dual-Pol TerraSAR-X images, 5 Pleiades images, and 6 Landsat-8 images. After calibrating the images, backscattering coefficients and polarimetric parameters were extracted from Terrasar-X images (entropy and alpha angle) and the NDVI from optical images. The analysis of the temporal signatures regarding perennial practices revealed a strong impact of the inter-row spacing management. Ranges of values of backscattering coefficients differ with the type of management but their temporal variation seems to be linked to soil moisture changes. Depending on the roughness of the inter-row spacing the alpha angle evolution is linked to grapevine growth in the case of a chemically weeded inter-row spacing. But it remains at high values when the inter-row spacing is ploughed or grassed. In those cases, the entropy increases along the growth cycle. The vegetation indexes series are increasing with the grapevine growth depending on canopy width and soil management. Thus this work highlighted the variability of the SAR and optical signals due to

  2. Detailed analysis of an Eigen quasispecies model in a periodically moving sharp-peak landscape

    Science.gov (United States)

    Neves, Armando G. M.

    2010-09-01

    The Eigen quasispecies model in a periodically moving sharp-peak landscape considered in previous seminal works [M. Nilsson and N. Snoad, Phys. Rev. Lett. 84, 191 (2000)10.1103/PhysRevLett.84.191] and [C. Ronnewinkel , in Theoretical Aspects of Evolutionary Computing, edited by L. Kallel, B. Naudts, and A. Rogers (Springer-Verlag, Heidelberg, 2001)] is analyzed in greater detail. We show here, through a more rigorous analysis, that results in those papers are qualitatively correct. In particular, we obtain a phase diagram for the existence of a quasispecies with the same shape as in the above cited paper by C. Ronnewinkel , with upper and lower thresholds for the mutation rate between which a quasispecies may survive. A difference is that the upper value is larger and the lower value is smaller than the previously reported ones, so that the range for quasispecies existence is always larger than thought before. The quantitative information provided might also be important in understanding genetic variability in virus populations and has possible applications in antiviral therapies. The results in the quoted papers were obtained by studying the populations only at some few genomes. As we will show, this amounts to diagonalizing a 3×3 matrix. Our work is based instead in a different division of the population allowing a finer control of the populations at various relevant genetic sequences. The existence of a quasispecies will be related to Perron-Frobenius eigenvalues. Although huge matrices of sizes 2ℓ , where ℓ is the genome length, may seem necessary at a first look, we show that such large sizes are not necessary and easily obtain numerical and analytical results for their eigenvalues.

  3. Spatially explicit analysis of metal transfer to biota: influence of soil contamination and landscape.

    Directory of Open Access Journals (Sweden)

    Clémentine Fritsch

    Full Text Available Concepts and developments for a new field in ecotoxicology, referred to as "landscape ecotoxicology," were proposed in the 1990s; however, to date, few studies have been developed in this emergent field. In fact, there is a strong interest in developing this area, both for renewing the concepts and tools used in ecotoxicology as well as for responding to practical issues, such as risk assessment. The aim of this study was to investigate the spatial heterogeneity of metal bioaccumulation in animals in order to identify the role of spatially explicit factors, such as landscape as well as total and extractable metal concentrations in soils. Over a smelter-impacted area, we studied the accumulation of trace metals (TMs: Cd, Pb and Zn in invertebrates (the grove snail Cepaea sp and the glass snail Oxychilus draparnaudi and vertebrates (the bank vole Myodes glareolus and the greater white-toothed shrew Crocidura russula. Total and CaCl(2-extractable concentrations of TMs were measured in soils from woody patches where the animals were captured. TM concentrations in animals exhibited a high spatial heterogeneity. They increased with soil pollution and were better explained by total rather than CaCl(2-extractable TM concentrations, except in Cepaea sp. TM levels in animals and their variations along the pollution gradient were modulated by the landscape, and this influence was species and metal specific. Median soil metal concentrations (predicted by universal kriging were calculated in buffers of increasing size and were related to bioaccumulation. The spatial scale at which TM concentrations in animals and soils showed the strongest correlations varied between metals, species and landscapes. The potential underlying mechanisms of landscape influence (community functioning, behaviour, etc. are discussed. Present results highlight the need for the further development of landscape ecotoxicology and multi-scale approaches, which would enhance our

  4. Analysis of surface soil moisture patterns in agricultural landscapes using Empirical Orthogonal Functions

    Directory of Open Access Journals (Sweden)

    W. Korres

    2010-05-01

    Full Text Available Soil moisture is one of the fundamental variables in hydrology, meteorology and agriculture. Nevertheless, its spatio-temporal patterns in agriculturally used landscapes that are affected by multiple natural (rainfall, soil, topography etc. and agronomic (fertilisation, soil management etc. factors are often not well known. The aim of this study is to determine the dominant factors governing the spatio-temporal patterns of surface soil moisture in a grassland and an arable test site that are located within the Rur catchment in Western Germany. Surface soil moisture (0–6 cm was measured in an approx. 50×50 m grid during 14 and 17 measurement campaigns (May 2007 to November 2008 in both test sites. To analyse the spatio-temporal patterns of surface soil moisture, an Empirical Orthogonal Function (EOF analysis was applied and the results were correlated with parameters derived from topography, soil, vegetation and land management to link the patterns to related factors and processes. For the grassland test site, the analysis resulted in one significant spatial structure (first EOF, which explained 57.5% of the spatial variability connected to soil properties and topography. The statistical weight of the first spatial EOF is stronger on wet days. The highest temporal variability can be found in locations with a high percentage of soil organic carbon (SOC. For the arable test site, the analysis resulted in two significant spatial structures, the first EOF, which explained 38.4% of the spatial variability, and showed a highly significant correlation to soil properties, namely soil texture and soil stone content. The second EOF, which explained 28.3% of the spatial variability, is linked to differences in land management. The soil moisture in the arable test site varied more strongly during dry and wet periods at locations with low porosity. The method applied is capable of identifying the dominant parameters controlling spatio-temporal patterns of

  5. Early treatment of trans-tibial amputees: retrospective analysis of early fitting and elastic bandaging

    NARCIS (Netherlands)

    Velzen, van A.D.; Nederhand, M.J.; Emmelot, C.H.; IJzerman, M.J.

    2005-01-01

    This study investigates the effects of early fitting in trans-tibial amputees. The assumption is that compared to elastic bandaging, the use of a rigid dressing in early fitting will result in quicker wound healing and earlier ambulation. A retrospective file search was carried out in three differen

  6. Distribution of Health-Related Physical Fitness in Texas Youth: A Demographic and Geographic Analysis

    Science.gov (United States)

    Welk, Gregory J.; Meredith, Marilu D.; Ihmels, Michelle; Seeger, Chris

    2010-01-01

    This study examined demographic and geographic variability in aggregated school-level data on the percentage of students achieving the FITNESSGRAM[R] Healthy Fitness Zones[TM] (HFZ). Three-way analyses of variance were used to examine differences in fitness achievement rates among schools that had distinct diversity and socioeconomic status…

  7. Convergence, Admissibility, and Fit of Alternative Confirmatory Factor Analysis Models for MTMM Data

    Science.gov (United States)

    Lance, Charles E.; Fan, Yi

    2016-01-01

    We compared six different analytic models for multitrait-multimethod (MTMM) data in terms of convergence, admissibility, and model fit to 258 samples of previously reported data. Two well-known models, the correlated trait-correlated method (CTCM) and the correlated trait-correlated uniqueness (CTCU) models, were fit for reference purposes in…

  8. Cardiovascular risk profile: Cross-sectional analysis of motivational determinants, physical fitness and physical activity

    NARCIS (Netherlands)

    Sassen, Barbara; Kok, Gerjo; Schaalma, Herman; Kiers, Henri; Vanhees, Luc

    2010-01-01

    Background: Cardiovascular risk factors are associated with physical fitness and, to a lesser extent, physical activity. Lifestyle interventions directed at enhancing physical fitness in order to decrease the risk of cardiovascular diseases should be extended. To enable the development of effective

  9. A 3-year longitudinal analysis of changes in fitness, physical activity, fatness and screen time

    DEFF Research Database (Denmark)

    Aires, L; Andersen, Lars Bo; Mendonça, D

    2010-01-01

    in fitness. METHODS: This is a 3-year longitudinal study of 345 high school students aged 11-19 years. Students performed curl-ups, push-ups and 20-m shuttle run tests from Fitnessgram. PA and ST were evaluated using a standard questionnaire. Standardized scores of fitness tests were summed. Changes over...

  10. Cardiovascular risk profile: Cross-sectional analysis of motivational determinants, physical fitness and physical activity

    NARCIS (Netherlands)

    Drs. Henri Kiers; Herman Schaalma; Drs. Barbara Sassen; Gerjo Kok; Prof. Dr. Luc L.E.M.J. Vanhees

    2010-01-01

    Background: Cardiovascular risk factors are associated with physical fitness and, to a lesser extent, physical activity. Lifestyle interventions directed at enhancing physical fitness in order to decrease the risk of cardiovascular diseases should be extended. To enable the development of effective

  11. Convergence, Admissibility, and Fit of Alternative Confirmatory Factor Analysis Models for MTMM Data

    Science.gov (United States)

    Lance, Charles E.; Fan, Yi

    2016-01-01

    We compared six different analytic models for multitrait-multimethod (MTMM) data in terms of convergence, admissibility, and model fit to 258 samples of previously reported data. Two well-known models, the correlated trait-correlated method (CTCM) and the correlated trait-correlated uniqueness (CTCU) models, were fit for reference purposes in…

  12. The role of landscape pattern analysis in understanding concepts of land cover change%景观类型分析在土地覆被变化中的作用

    Institute of Scientific and Technical Information of China (English)

    Jerry A Griffith

    2004-01-01

    Landscape ecology and landscape pattern analysis are important components of national-scale programs to identify trends in land cover change because: 1) Statistics on changes in land cover proportions are not spatial. A change matrix derived from GIS provides useful information,but it does not show the spatial form of change in the landscape. Landscape pattern metrics reveal spatial pattern. 2) A growing body of literature has shown that a change in landscape pattern might indicate important changes in ecological functions: forest connectivity and species movements, number and size of farm patches, effects on water quality. Spatial pattern is important in structuring ecological communities and in maintaining existence of competitors. Spatial pattern may be determined by disturbance and may in turn, determine how disturbances propagate through the system. 3) Sometimes landscape pattern may not significantly change, even though land cover proportions do change. Or,vice-versa, sometimes landscape pattern can significantly change, even though land cover proportions don't significantly change. 4) Landscape pattern is an inherent and important part of describing landscapes: based on the literature, one of the most important descriptive characteristics of a landscape is its texture. The objectives of this paper are to: 1) Explain the importance of the role of landscape ecology and landscape pattern analysis in land cover change studies; 2) Review the literature that specifically incorporates landscape ecology into land cover change studies; and 3) List the theoretical and technical issues involved and suggest solutions for them.

  13. Variance analysis for model updating with a finite element based subspace fitting approach

    Science.gov (United States)

    Gautier, Guillaume; Mevel, Laurent; Mencik, Jean-Mathieu; Serra, Roger; Döhler, Michael

    2017-07-01

    Recently, a subspace fitting approach has been proposed for vibration-based finite element model updating. The approach makes use of subspace-based system identification, where the extended observability matrix is estimated from vibration measurements. Finite element model updating is performed by correlating the model-based observability matrix with the estimated one, by using a single set of experimental data. Hence, the updated finite element model only reflects this single test case. However, estimates from vibration measurements are inherently exposed to uncertainty due to unknown excitation, measurement noise and finite data length. In this paper, a covariance estimation procedure for the updated model parameters is proposed, which propagates the data-related covariance to the updated model parameters by considering a first-order sensitivity analysis. In particular, this propagation is performed through each iteration step of the updating minimization problem, by taking into account the covariance between the updated parameters and the data-related quantities. Simulated vibration signals are used to demonstrate the accuracy and practicability of the derived expressions. Furthermore, an application is shown on experimental data of a beam.

  14. Caste fate conflict in swarm-founding social hymenoptera: an inclusive fitness analysis.

    Science.gov (United States)

    Wenseleers, T; Ratnieks, F L W; Billen, J

    2003-07-01

    A caste system in which females develop into morphologically distinct queens or workers has evolved independently in ants, wasps and bees. Although such reproductive division of labour may benefit the colony it is also a source of conflict because individual immature females can benefit from developing into a queen in order to gain greater direct reproduction. Here we present a formal inclusive fitness analysis of caste fate conflict appropriate for swarm-founding social Hymenoptera. Three major conclusions are reached: (1) when caste is self-determined, many females should selfishly choose to become queens and the resulting depletion of the workforce can substantially reduce colony productivity; (2) greater relatedness among colony members reduces this excess queen production; (3) if workers can prevent excess queen production at low cost by controlled feeding, a transition to nutritional caste determination should occur. These predictions generalize results derived earlier using an allele-frequency model [Behav. Ecol. Sociobiol. (2001) 50: 467] and are supported by observed levels of queen production in various taxa, especially stingless bees, where caste can be either individually or nutritionally controlled.

  15. A systematic analysis of the optical merit function landscape: towards improved optimization methods in optical design

    NARCIS (Netherlands)

    Van Turnhout, M.

    2009-01-01

    A major problem in optical system design is that the optical merit function landscape is usually very complicated, especially for complex design problems where many minima are present. Finding good new local minima is then a difficult task. We show however that a certain degree of order is present i

  16. Exploration and Analysis of Space Molding by Plants in Landscape Environment

    Institute of Scientific and Technical Information of China (English)

    袁文欣

    2016-01-01

    The plant population can not only effectively divide the space, but can also set off and decorate the space. The great plantation of plants should be systematic to express and emphasize the site layout, which plays an irreplaceable role in landscape design.

  17. Kriging analysis of soil properties: Implication to landscape management and productivity improvement

    Science.gov (United States)

    Soil as a landscape entity contains wide ranges of physical, chemical, morphological, and mineralogical properties, both laterally and vertically. Soils with similar properties and environments are expected to behave similarly. Statement of land use potential depends in part on the precision and acc...

  18. The Singapore Global Schoolhouse: An Analysis of the Development of the Tertiary Education Landscape in Singapore

    Science.gov (United States)

    Ng, Pak Tee; Tan, Charlene

    2010-01-01

    Purpose: This paper seeks to analyse the Singapore government's recent attempt to make Singapore a "Global Schoolhouse" by transforming its tertiary education sector. It aims to examine the government's attempt to promote greater diversity and autonomy in the tertiary education landscape; it also aims to examine the government's systems…

  19. Frozen Actions in the Arctic Linguistic Landscape: A Nexus Analysis of Language Processes in Visual Space

    Science.gov (United States)

    Pietikainen, Sari; Lane, Pia; Salo, Hanni; Laihiala-Kankainen, Sirkka

    2011-01-01

    This article examines the linguistic landscape (LL) of seven villages above the Arctic Circle, in the region called North Calotte. The area forms a complex nexus of contested and changing multilingualism, particularly as regards to endangered indigenous Sami languages and Kven and Meankieli minority languages. Viewing LL as a discursively…

  20. GEOINFORMATION ANALYSIS OF THE INDEX OF BIOLOGICAL EFFICIENCY OF CLIMATE AS CRITERION FOR EVALUATION OF POTENTIAL STABILITY OF THE LANDSCAPE

    Directory of Open Access Journals (Sweden)

    A. N. Ogurtsov

    2017-01-01

    Full Text Available The article considers indicator approach to assessment of potential stability of landscapes. As an example of integrated criterion the index of climate biological efficiency (TK has been used. Calculations of TK index for assessment of stability of landscapes have been executed for the territory of Tver Region. Cartograms of TK index and its components have been made. Geospatial analysis has been carried out and estimates of potential stability of landscapes are given. The example of mapping and calculation of the TK index serves as a starting point for using it in multi-criteria assessment of the state and emergent properties of geosystems built on the principles of ASPID-methodology. This example reflects the possibility of using the indicator approach in the first stage of the study of resistance to changes in the parameters of natural regime for the subsequent multicriteria and integral assessment of resistance to changes in the parameters of natural and anthropogenic regimes of geosystems functioning. The use of the index of climate biological efficiency as an indicator of sustainability will make it possible to actively use it in future in geoecological research.

  1. LiDAR and Orthophoto Synergy to optimize Object-Based Landscape Change: Analysis of an Active Landslide

    Directory of Open Access Journals (Sweden)

    Martijn Kamps

    2017-08-01

    Full Text Available Active landslides have three major effects on landscapes: (1 land cover change, (2 topographical change, and (3 above ground biomass change. Data derived from multi-temporal Light Detection and Ranging technology (LiDAR are used in combination with multi-temporal orthophotos to quantify these changes between 2006 and 2012, caused by an active deep-seated landslide near the village of Doren in Austria. Land-cover is classified by applying membership-based classification and contextual improvements based on the synergy of orthophotos and LiDAR-based elevation data. Topographical change is calculated by differencing of LiDAR derived digital terrain models. The above ground biomass is quantified by applying a local-maximum algorithm for tree top detection, in combination with allometric equations. The land cover classification accuracies were improved from 65% (using only LiDAR and 76% (using only orthophotos to 90% (using data synergy for 2006. A similar increase from respectively 64% and 75% to 91% was established for 2012. The increased accuracies demonstrate the effectiveness of using data synergy of LiDAR and orthophotos using object-based image analysis to quantify landscape changes, caused by an active landslide. The method has great potential to be transferred to larger areas for use in landscape change analyses.

  2. Analysis of human induced changes in a karst landscape - the filling of dolines in the Kras plateau, Slovenia.

    Science.gov (United States)

    Kovačič, Gregor; Ravbar, Nataša

    2013-03-01

    A comprehensive analysis of the increased pressure on karst landscapes due to expansive economic and urban development is presented with the aim of evaluating changes in land use and their deleterious effects on karst relief forms. The study focuses on two areas surrounding the relatively quickly growing settlements of Hrpelje-Kozina and Divača on the Kras plateau (Slovenia) that have been subjected to intensive urban and business development and traffic since the motorway was brought to their vicinity fifteen years ago. National legislation loopholes and technological improvement were the cause of the commonly unsupervised human encroachment which caused the widespread degradation of the landscape. By comparing different topographical and ortophotographical materials from the past four decades and by detailed field inspection of land use and environmental changes, as well as the morphometrical characterization of dolines, the following results have been found: due to the population growth in the past four decades (39% and 50%, respectively), an increase of settlement area by 18 and 11 percentage points took place. Consequently, between 25 and 27% of dolines have disappeared or have been extensively modified (filled up and leveled). According to the local spatial plans, an additional 18% to 28% dolines are endangered. Broad human induced changes in the karst landscape have resulted in a noticeable increase in landscape deterioration, which is consistent with similar phenomena observed in other regions. Due to the extreme susceptibility of the karst to human activities that may lead to the degradation of its exceptional esthetic and environmental value, the alteration of karst processes such as corrosion, endangering of unique habitats and the quality of non-renewable natural resources, it is necessary to promptly define measures for its protection at the national level. Copyright © 2013 Elsevier B.V. All rights reserved.

  3. Assessment of land use and land cover change using spatiotemporal analysis of landscape: case study in south of Tehran.

    Science.gov (United States)

    Sabr, Abutaleb; Moeinaddini, Mazaher; Azarnivand, Hossein; Guinot, Benjamin

    2016-12-01

    In the recent years, dust storms originating from local abandoned agricultural lands have increasingly impacted Tehran and Karaj air quality. Designing and implementing mitigation plans are necessary to study land use/land cover change (LUCC). Land use/cover classification is particularly relevant in arid areas. This study aimed to map land use/cover by pixel- and object-based image classification methods, analyse landscape fragmentation and determine the effects of two different classification methods on landscape metrics. The same sets of ground data were used for both classification methods. Because accuracy of classification plays a key role in better understanding LUCC, both methods were employed. Land use/cover maps of the southwest area of Tehran city for the years 1985, 2000 and 2014 were obtained from Landsat digital images and classified into three categories: built-up, agricultural and barren lands. The results of our LUCC analysis showed that the most important changes in built-up agricultural land categories were observed in zone B (Shahriar, Robat Karim and Eslamshahr) between 1985 and 2014. The landscape metrics obtained for all categories pictured high landscape fragmentation in the study area. Despite no significant difference was evidenced between the two classification methods, the object-based classification led to an overall higher accuracy than using the pixel-based classification. In particular, the accuracy of the built-up category showed a marked increase. In addition, both methods showed similar trends in fragmentation metrics. One of the reasons is that the object-based classification is able to identify buildings, impervious surface and roads in dense urban areas, which produced more accurate maps.

  4. Effect of translation and rotation fitting on analysis of corneal topography.

    Science.gov (United States)

    Deng, Man Li; Li, Lin Na; Huang, Li Fang; Wang, Wenwen; Yu, A Yong; Huang, Jin Hai; Wang, Qin Mei; Bao, Fang Jun; Elsheikh, Ahmed

    2015-01-01

    The purpose was to assess the suitability of quadratic equations for the accurate representation of corneal topography and consider the effect of translation and rotation fitting on the quality of fit and the curvature results. Topography images were recorded for the anterior and posterior surfaces of 490 corneas of 490 myopic patients using Pentacam. Elevation data were fitted to four shape models, three of which considered translational and/or rotational fitting. Differences between the models in the estimates of radii of curvature (R) and asphericity coefficients (Q) and in the quality of fit (as measured by the root mean square (RMS) error and the structural similarity index (SSIM)) were statistically analysed. The general shape model that considered both translational and rotational misalignments provided the best fit for the anterior (RMS = 1.18 ± 0.56 µm, SSIM = 0.99 ± 0.01) and posterior (RMS 3.64 ± 1.23 µm, SSIM = 0.99 ± 0.01) corneal surfaces in all subjects. The quality of fit degraded significantly (with p corneal topography. The effects of misalignments on the estimates of corneal radius and asphericity are statistically significant and may in some cases be clinically significant.

  5. The extended Lennard-Jones potential energy function: A simpler model for direct-potential-fit analysis

    Science.gov (United States)

    Hajigeorgiou, Photos G.

    2016-12-01

    An analytical model for the diatomic potential energy function that was recently tested as a universal function (Hajigeorgiou, 2010) has been further modified and tested as a suitable model for direct-potential-fit analysis. Applications are presented for the ground electronic states of three diatomic molecules: oxygen, carbon monoxide, and hydrogen fluoride. The adjustable parameters of the extended Lennard-Jones potential model are determined through nonlinear regression by fits to calculated rovibrational energy term values or experimental spectroscopic line positions. The model is shown to lead to reliable, compact and simple representations for the potential energy functions of these systems and could therefore be classified as a suitable and attractive model for direct-potential-fit analysis.

  6. 西安市健身俱乐部会员锻炼现状与特征调查分析——以皇室、亚特和美格菲为例%Investigation and Analysis of Fitness Feature and Status of Physical Exercise of Members of Fitness Club in Xi'an City:Taking Royal Fitness Club, Yate Fitness Club and Megafit Fitness Club for Examples

    Institute of Scientific and Technical Information of China (English)

    杨建设

    2012-01-01

    The paper made an investigation and analysis on the status of physical exercise and fitness feature of members who are in Royal Fitness Club, Yate Fitness Club and Megafit Fitness Club by using questionnaires and field observation. The survey results show that female members are more than male members in fitness clubs, the majority of members are young and middle-aged, and have high education, stable income, their occupational distribution is wide, and fitness motivation, choice of exercise program are varied- It also has obvious features in hebdomadal number of fitness, daily fitness time and the duration of fitness at a time. Members have higher degree of satisfaction to coaches and customer service. Doing housework and being busy with work are the main factors restraining members from participating in fitness.%通过问卷调查法和实地观察法对西安市皇室、亚特和美格菲三家健身俱乐部会员的锻炼现状和健身特征进行调查与分析.调查结果表明参与健身的女性会员明显多于男性会员,会员以高学历、稳定收入和中青年为主,会员的职业分布广泛,健身动机、选择锻炼项目多样,周健身次数、每日健身时段和每次健身持续时间特征明显,会员对教练员和客户服务满意度较高,做家务、工作忙没时间成为制约会员健身的最主要因素.

  7. Unnameable landscapes

    Directory of Open Access Journals (Sweden)

    John Stuart-Murray

    1995-10-01

    Full Text Available This paper outlines the key concepts of opacity, back formation and toponymic activity used by place name historians, and relates them to the naming of contemporary artefacts in the cultural landscape. It categorises place names according to a three-layered analytical model of landscape and argues that place naming is now carried out largely within a cultural framework. Exceptions are names given by modern recreationalists who have regained something of the intimate relationship with the land possessed by earlier agricultural societies. This view is supported by findings that students of landscape architecture have difficulty in naming and describing character where landscapes have been shaped largely by physical and biological processes. It is also consistent with the increasing articulation of landscapes at the cultural level independent of physical and natural process, allowed by the sophistication of modern technology.

  8. A simulation method for the stability analysis of landscape scenarios by using a NetLogo application in GIS environment

    Science.gov (United States)

    Gobattoni, Federica; Lauro, Giuliana; Leone, Antonio; Monaco, Roberto; Pelorosso, Raffaele

    2010-05-01

    could be able to predict the response of the landscape working as a unique system, are expected to advance through a development of sustainable planning strategies and to evaluate the equilibrium-non equilibrium status of landscape evolution and the availability of vital resources in space and time. In this context mathematical models adapted in GIS environment may really give an heavy contribution in such a complex problem- solving, providing a real and concrete Decision System Support. An integrated GIS (Geographic Information System)-based approach was developed (G. Lauro, R. Monaco, 2008) combining an ecological graph model for the analysis of the relationship between spatial pattern and ecological flows and a mathematical model, based on a system of two nonlinear differential equations, that studies meta-stability and bifurcation phenomena. These equations are mainly based on a balance law between a logistic growth of bio-energy and its reduction due to limiting factors coming from environmental constraints. The energy exchange among them will be more or less strong depending on the degree of permeability of the barriers which can obstruct the energy passage from each "landscape unit" to the other. Through NetLogo, a cross-platform multi-agent programmable modelling environment, a completely automatic GIS-based mathematical model, based on the ecological graph and on the cited two differential equations, is presented and discussed here. A study case in Central Italy is analysed to better underline the importance of such a user friendly model in GIS environment.

  9. The analysis of modern approaches to physical fitness testing of military personnel

    Directory of Open Access Journals (Sweden)

    Glazunov Sergej Ivanovich

    2011-11-01

    Full Text Available The aim of research is to determine modern approaches to the physical fitness testing of service personnel. In the army with modern military experience, marked by a tendency to view the content of tests to determine the level of physical fitness of military personnel. Observed differentiation of unified systems tests to determine the general physical and military training military application. Summary of tests determined the nature of loads and motions of the structure inherent in the military during combat operations.

  10. The Impact of BIB Spiraling-Induced Missing Data Patterns on Goodness-of-Fit Tests in Factor Analysis.

    Science.gov (United States)

    Kaplan, David

    1995-01-01

    This article considers the impact of missing data arising from balanced incomplete block (BIB) spiraled designs on the chi-square goodness-of-fit test in factor analysis. The new approach is shown to outperform the pairwise available case method for continuous variables and to be comparatively better for dichotomous variables. (SLD)

  11. From Perceived Values to Shared Values: A Multi-Stakeholder Spatial Decision Analysis (M-SSDA for Resilient Landscapes

    Directory of Open Access Journals (Sweden)

    Maria Cerreta

    2017-06-01

    Full Text Available This paper puts forth a Multi-Stakeholder Spatial Decision Analysis (M-SSDA which combines Multi-Stakeholders Decision Analysis (M-SDA and GIS processing based on a collaborative, hybrid and adaptive evaluative approach to support the elaboration of enhancement strategies designed for resilient landscapes. This methodology has been tested in the research project “Cilento Labscape: An integrated model for the activation of a Living Lab in the National Park of Cilento, Vallo di Diano and Alburni”, which was conducted in the Cilento National Park (Southern Italy. The aim of the methodology is to find alternative touristic routes for the promotion of the Park. The different steps in the process will be described, as will the employment of multiple tools/techniques (interviews, GIS tools, Semantic Analysis, and Geo-Statistical Analysis to improve the reliability of the decision-making process. The most relevant results of the methodology will also be outlined in terms of the transition from the identification of the perceived landscape’s values to the acknowledgement of the shared values, and their consequent employment for the outlining of new thematic itineraries for the Park. To realise sustainable territorial strategies and preserve the landscape through bottom-up decision-making processes, the different local communities need to gain a new awareness of their identity shared values and make an active contribution towards promoting and managing their site-specific resources.

  12. Spatio-temporal analysis of the urban-rural gradient structure: an application in a Mediterranean mountainous landscape (Serra San Bruno, Italy)

    Science.gov (United States)

    Modica, G.; Vizzari, M.; Pollino, M.; Fichera, C. R.; Zoccali, P.; Di Fazio, S.

    2012-12-01

    The most recent and significant transformations of European landscapes have occurred as a consequence of a series of diffused, varied and often connected phenomena: urban growth and sprawl, agricultural intensification in the most suitable areas and agricultural abandonment in marginal areas. These phenomena can affect dramatically ecosystems' structure and functioning, since certain modifications cause landscape fragmentation while others tend to increase homogeneity. Thus, a thorough comprehension of the evolution trends of landscapes, in particular those linked to urban-rural relations, is crucial for a sustainable landscape planning. In this framework, the main objectives of the present paper are: (a) to investigate Land Use/Land Cover (LULC) transformations and dynamics that occurred over the period 1955-2006 in the municipality of Serra San Bruno (Calabria, Italy), an area particularly representative of the Mediterranean mountainous landscape; (b) to compare the settlement growth with the urban planning tools in charge in the study area; (c) to examine the relationship between urban-rural gradient, landscape metrics, demographic and physical variables; (d) to investigate the evolution of urban-rural gradient composition and configuration along significant axes of landscape changes. Data with a high level of detail (minimum mapping unit 0.2 ha) were obtained through the digitisation of historical aerial photographs and digital orthophotos identifying LULC classes according to the Corine Land Cover legend. The investigated period was divided into four significant time intervals, which were specifically analysed to detect LULC changes. Differently from previous studies, in the present research the spatio-temporal analysis of urban-rural gradient was performed through three subsequent steps: (1) kernel density analysis of settlements; (2) analysis of landscape structure by means of metrics calculated using a moving window method; (3) analysis of composition and

  13. Spatio-temporal analysis of the urban-rural gradient structure: an application in a Mediterranean mountainous landscape (Serra San Bruno, Italy

    Directory of Open Access Journals (Sweden)

    G. Modica

    2012-08-01

    Full Text Available The most recent and significant transformations of European landscapes have occurred as a consequence of a series of diffused, varied and often connected phenomena: urban growth and sprawl, agricultural intensification in the most suitable areas and agricultural abandonment in marginal areas. These phenomena can affect dramatically ecosystems' structure and functioning, since certain modifications cause landscape fragmentation while others tend to increase homogeneity. Thus, a thorough comprehension of the evolution trends of landscapes, in particular those linked to urban-rural relations, is crucial for a sustainable landscape planning.

    In this framework, the main objectives of the present paper are: (a to investigate Land Use/Land Cover (LULC transformations and dynamics occurred over the period 1955–2006 in the municipality of Serra San Bruno (Calabria, Italy, an area particularly representative of the Mediterranean mountainous landscape; (b to compare the settlement growth with the urban planning tools in charge in the study area; (c to examine the relationship between urban-rural gradient, landscape metrics, demographic and physical variables; (d to investigate the evolution of urban-rural gradient composition and configuration along significant axes of landscape changes.

    Data with a high level of detail (minimum mapping unit 0.2 ha were obtained through the digitisation of historical aerial photographs and digital orthophotos identifying LULC classes according to the Corine Land Cover legend. The investigated period was divided into four significant time intervals, which were specifically analysed to detect LULC changes.

    Differently from previous studies, in the present research the spatio-temporal analysis of urban-rural gradient was performed through three subsequent steps: (1 kernel density analysis of settlements; (2 analysis of landscape structure by means of metrics calculated using a moving window method

  14. Are all models created equal? A content analysis of women in advertisements of fitness versus fashion magazines.

    Science.gov (United States)

    Wasylkiw, L; Emms, A A; Meuse, R; Poirier, K F

    2009-03-01

    The current study is a content analysis of women appearing in advertisements in two types of magazines: fitness/health versus fashion/beauty chosen because of their large and predominantly female readerships. Women appearing in advertisements of the June 2007 issue of five fitness/health magazines were compared to women appearing in advertisements of the June 2007 issue of five beauty/fashion magazines. Female models appearing in advertisements of both types of magazines were primarily young, thin Caucasians; however, images of models were more likely to emphasize appearance over performance when they appeared in fashion magazines. This difference in emphasis has implications for future research.

  15. Linear-fitting-based similarity coefficient map for tissue dissimilarity analysis in -w magnetic resonance imaging

    Science.gov (United States)

    Yu, Shao-De; Wu, Shi-Bin; Wang, Hao-Yu; Wei, Xin-Hua; Chen, Xin; Pan, Wan-Long; Hu, Jiani; Xie, Yao-Qin

    2015-12-01

    Similarity coefficient mapping (SCM) aims to improve the morphological evaluation of weighted magnetic resonance imaging However, how to interpret the generated SCM map is still pending. Moreover, is it probable to extract tissue dissimilarity messages based on the theory behind SCM? The primary purpose of this paper is to address these two questions. First, the theory of SCM was interpreted from the perspective of linear fitting. Then, a term was embedded for tissue dissimilarity information. Finally, our method was validated with sixteen human brain image series from multi-echo . Generated maps were investigated from signal-to-noise ratio (SNR) and perceived visual quality, and then interpreted from intra- and inter-tissue intensity. Experimental results show that both perceptibility of anatomical structures and tissue contrast are improved. More importantly, tissue similarity or dissimilarity can be quantified and cross-validated from pixel intensity analysis. This method benefits image enhancement, tissue classification, malformation detection and morphological evaluation. Project supported in part by the National High Technology Research and Development Program of China (Grant Nos. 2015AA043203 and 2012AA02A604), the National Natural Science Foundation of China (Grant Nos. 81171402, 61471349, and 81501463), the Innovative Research Team Program of Guangdong Province, China (Grant No. 2011S013), the Science and Technological Program for Higher Education, Science and Research, and Health Care Institutions of Guangdong Province, China (Grant No. 2011108101001), the Natural Science Foundation of Guangdong Province, China (Grant No. 2014A030310360), the Fundamental Research Program of Shenzhen City, China (Grant No. JCYJ20140417113430639), and Beijing Center for Mathematics and Information Interdisciplinary Sciences, China.

  16. Nintendo wii sports and wii fit game analysis, validation, and application to stroke rehabilitation.

    Science.gov (United States)

    Deutsch, Judith E; Brettler, Arielle; Smith, Caroline; Welsh, Jamie; John, Roshan; Guarrera-Bowlby, Phyllis; Kafri, Michal

    2011-01-01

    Interactive video gaming has become ubiquitous in the practice of rehabilitation. The Nintendo Wii is one such system. Interactive gaming can promote intensive task-based therapy in a manner that is motivating for the user. Widespread enthusiasm for consoles and their games prompted us to analyze the games for their rehabilitation elements related to improving balance and mobility for individuals poststroke. The purpose of this article is to provide a game analysis for clinical application and evaluation of the game elements for research on interactive video gaming. Using a team of game players and raters, 5 tables (1 for the Wii Sports and 4 for the Wii Fit) were developed and validated. The tables consist of 3 categories: game description, impairments targeted (strength, endurance, balance, and coordination), and feedback provided (knowledge of performance [KP] and knowledge of results [KR]). Two domain content experts established face validity. Construct validity was performed by 2 therapist-raters who had more than 15 years' clinical experience and postgraduate training in motor learning. Observations about the games including the fidelity of the interfaces, the nature of the feedback, and some of the challenges to adapting the games for rehabilitation are presented. An 80% agreement between raters set as the criterion for establishing the construct validity was met for feedback evaluation. There was 100% agreement on impairment ratings. Games provide a greater amount of KR compared with KP. Given the preponderance of KR, therapists will need to monitor motor performance. Adaptation of interactive video consoles for rehabilitation requires careful evaluation of the games' attributes using relevant rehabilitation construits.

  17. Levels of physical fitness and analysis of posture tendencies in classic ballerinas

    Directory of Open Access Journals (Sweden)

    Alessandra Prati

    2006-03-01

    Full Text Available Classic ballet is a dance practiced by children and adolescents along all their development process. To get to the high level of technique and performance, it is necessary more than seven years of practice. In this way, the repetition of the technical movements can promote the acquisition of some posture problems, as well as to develop aspects of the specific physical fitness. The aim of this descriptive study was to analyze physical fitness level and posture of ballet dancers. The sample was composed by eleven dancers with more than seven years of practice from ballet schools in Maringá, Paraná. For analysis of posture, the method PSU adapted by Althoff et al. (1988 was applied by using subjective evaluation through symmetrigraf view and deviations analyses of body segments (normal when index of postural correction -IPC>85%. Physical fitness level was determined by anthropometry to identify body composition (body mass index=BMI, % body fat, waist-to-hip ratio, strength test (dynamometry=D, arm strength (SA, abdominal resistance (AR, muscle power (vertical jump=VJ and long jump=LJ, the sit-and-reach test (Fl and aerobic work capacity (12 minute test. The main results were mean body composition (BMI=19.9kg.m-2; % body fat=22.7% and waist-to-hip ratio=0.69 was appropriate to the activity. Strength and resistance (D=50.3kgf, SA=21, AR=23 and Fl=40cm, muscle power (VJI=36.8cm and LJ=136cm and aerobic resistance (12min=1526m mean values were lower than expected. It was noticed that the dancers presented mean IPC of 86,9%. The segment head and neck showed deviations (13% kyphosis, as well as upper and lower back region (8% hyperlordosis, abdomen and hip (13% protruding abdomen and one higher hip and lower limbs (18% flat feet. The results lead to infer that the posture deviations observed can be consequence of the repetition of characteristic ballet movements along years of training. It is thought that for better performance in this long

  18. BMI as a mediator of the relationship between muscular fitness and cardiometabolic risk in children: a mediation analysis.

    Directory of Open Access Journals (Sweden)

    Ana Díez-Fernández

    Full Text Available Muscular fitness levels have been associated with cardiometabolic risk in children, although whether body weight acts as a confounder or as an intermediate variable in this relationship remains controversial. The aim of this study was to examine whether the association between muscular fitness and cardiometabolic risk factors is mediated by body mass index (BMI.Cross-sectional study using a sample of 1158 schoolchildren aged 8-11 years from the province of Cuenca, Spain. We measured anthropometrics and biochemical variables and we calculated a muscular fitness index as the sum of z-scores of handgrip dynamometry/weight and standing long jump, and we estimated a previously validated cardiometabolic risk index (CMRI. Linear regression models were fitted for mediation analysis to assess whether the association between muscular fitness and cardiometabolic risk was mediated by BMI.Children with normal weight (NW had a better cardiometabolic risk profile than their overweight (OW or obese (OB peers after controlling for muscular fitness. Marginal estimated mean ± SE values for NW, OW and OB categories of CMRI were -0.75 ± 0.06 0.05 ± 0.09 >-1.16 ± 0.13 for lower, middle and upper quartiles of muscular fitness in boys and 1.01 ± 0.16 > 0.10 ± 0.09 > -1.02 ± 0.15 in girls, both p < 0.001, but differences disappeared when controlling for BMI. BMI acted as a full mediator between muscular fitness and most cardiometabolic risk factors (Sobel test z = -11.44 for boys; z = -11.83 for girls; p < 0.001 in CMRI mediation model and as a partial mediator in the case of waist circumference (Sobel test z=-14.86 for boys; z=-14.51 for girls; p<0.001.BMI mediates the association between muscular fitness and cardiometabolic risk in schoolchildren. Overall, good muscular fitness is associated with lower cardiometabolic risk, but particularly when accompanied by normal weight.

  19. Low-Cost Mapping and Publishing Methods for Landscape Architectural Analysis and Design in Slum-Upgrading Projects

    Directory of Open Access Journals (Sweden)

    Jörg Rekittke

    2011-10-01

    Full Text Available The research project “Grassroots GIS” focuses on the development of low-cost mapping and publishing methods for slums and slum-upgrading projects in Manila. In this project smartphones, collaborative mapping and 3D visualization applications are systematically employed to support landscape architectural analysis and design work in the context of urban poverty and urban informal settlements. In this paper we focus on the description of the developed methods and present preliminary results of this work-in-progress.

  20. Landscape analysis as a theoretical-methodological tool and bridge for territory socio-environmental management

    OpenAIRE

    Susana Barrera Lobatón

    2013-01-01

    This paper attempts to understand how the concept of landscape is transformed from its academic production and discussion to its adaptation by the State; and also how this concept ends up being applied on the territory by various professionals interested in it. In order to do this we look at some definitions developed by various disciplines: Geography, Anthropology, Archeology, Ecology, Agronomy and Architecture, highlighting key points; and we make a comparison between their proposals and th...

  1. Landscape Participatory Planning in the Digital City: Analysis of the Potentialities in Curitiba, Paraná

    Directory of Open Access Journals (Sweden)

    Regina Maria Martins de Araujo Klein

    2016-12-01

    Full Text Available The technologies and services applied in a virtual environment offer alternative inclusion of citizens in the urban scenes qualification process, it is therefore desirable for the prevention of lack of articulation of landscape theme in the public administration sphere. Given these assumptions, the central question of the research focused on the interpretation of the incorporation possibilities real theme and factual participation of the population in municipal management through technological information resources. In this context, the main research objective is to analyze the potential of participatory planning of the landscape in the digital city. Thus, it is supported by documentary study on the reality of Curitiba, State of Parana. The observation unit covered the intervening legislation in green areas composition, defined as relevant clippings of landscape components of the urban area. Legal standards were associated with both qualitative and quantitative parameters of morphological and compositional elements as the interface with the community perspectives. The results demonstrate the lack of effective integration of urban dwellers in the current planning processes of these spaces in Curitiba. Notwithstanding the procedures adopted limitations, the conclusion indicates existence of capacity expansion in this connection within the digital city. This fact diagnosed by identifying enhancement opportunities of citizen’s virtual involvement and technological diversity options for this purpose.

  2. Analysis of land use and landscape pattern on university campus%高校校园土地利用与景观格局分析研究

    Institute of Scientific and Technical Information of China (English)

    赵敏; 程维明; 李雅素

    2014-01-01

    为讨论西北农林科技大学校园景观布局的优劣,对今后规划工作提供依据,以CAD校园平面图和高清遥感影像为基础资料,采用独创性的景观划分法,利用ArcMap获取南北校区校园土地利用与景观格局的空间分布,并运用各类景观指标,对景观格局进行定量分析。结果表明:南校区各景观的破碎度均大于北校,而优势度偏低;就全校范围来看,多样性、均匀度、优势度最大的分别为生活景观(1.858)、绿地景观(0.97)、娱乐景观(0.617),娱乐景观的均匀度最低,绿地景观的优势度最小;北校区的建筑设施(包括教学、生活、娱乐、附属设施)对景观的支配作用较大,南校区各景观受人为因素影响较大。简而言之,全校景观空间格局分布合理,功能区划协调统一。%In order to analysis the landscape layout of north campus, south campus and the whole campus, discuss the advantages and disadvantages of the current landscape layout and provide a basis for future campus pattern, this paper put the nwsuaf CAD-campus plan and HD remote sensing image as the basic data, combined with topographic map of Yangling District, made use of the unique methods of landscape pattern and used Landscape Ecology-related indicators to analysis the North-South Campus land use and landscape pattern distribution. The results show that: ①Each landscape fragmentation in the South Campus is greater than that in the North South, the advantage of the North Campus buildings are higher than the North Campus; ② On school-wide perspective, the living facilities landscape, the green landscape and the recreational amenities landscape respectively have the greatest diversity, evenness, dominance. Evenness of the recreational amenities landscape is the lowest. Advantage of the green landscape is the least. ③ Building facilities (including teaching, living, entertainment, ancillary facilities

  3. The general environment fit scale: a factor analysis and test of convergent construct validity.

    Science.gov (United States)

    Beasley, Christopher R; Jason, Leonard A; Miller, Steven A

    2012-09-01

    Person-environment fit (P-E fit) was initially espoused as an important construct in the field of community psychology; however, most of the theoretical and empirical development of the construct has been conducted by the industrial/organizational (I/O) psychologists and business management fields. In the current study, the GEFS-a P-E fit measure that was developed from organizational perspectives on fit-was administered to 246 attendees of an annual convention for residents and alumni of Oxford House, a network of over 1,400 mutual-help addiction recovery homes. The authors conducted confirmatory factor and convergent construct validity analyses with the GEFS. The results suggested that the theoretical factor structure of the measure adequately fit the data and provided limited support for the measure's validity. Sufficient supply of resident needs by the Oxford House and similarity between residents and their housemates predicted satisfaction with the recovery home, but only perceived similarity to housemates predicted how long residents intended to stay in the Oxford Houses.

  4. Geostatistical analysis of groundwater level using Euclidean and non-Euclidean distance metrics and variable variogram fitting criteria

    Science.gov (United States)

    Theodoridou, Panagiota G.; Karatzas, George P.; Varouchakis, Emmanouil A.; Corzo Perez, Gerald A.

    2015-04-01

    Groundwater level is an important information in hydrological modelling. Geostatistical methods are often employed to map the free surface of an aquifer. In geostatistical analysis using Kriging techniques the selection of the optimal variogram model is very important for the optimal method performance. This work compares three different criteria, the least squares sum method, the Akaike Information Criterion and the Cressie's Indicator, to assess the theoretical variogram that fits to the experimental one and investigates the impact on the prediction results. Moreover, five different distance functions (Euclidean, Minkowski, Manhattan, Canberra, and Bray-Curtis) are applied to calculate the distance between observations that affects both the variogram calculation and the Kriging estimator. Cross validation analysis in terms of Ordinary Kriging is applied by using sequentially a different distance metric and the above three variogram fitting criteria. The spatial dependence of the observations in the tested dataset is studied by fitting classical variogram models and the Matérn model. The proposed comparison analysis performed for a data set of two hundred fifty hydraulic head measurements distributed over an alluvial aquifer that covers an area of 210 km2. The study area is located in the Prefecture of Drama, which belongs to the Water District of East Macedonia (Greece). This area was selected in terms of hydro-geological data availability and geological homogeneity. The analysis showed that a combination of the Akaike information Criterion for the variogram fitting assessment and the Brays-Curtis distance metric provided the most accurate cross-validation results. The Power-law variogram model provided the best fit to the experimental data. The aforementioned approach for the specific dataset in terms of the Ordinary Kriging method improves the prediction efficiency in comparison to the classical Euclidean distance metric. Therefore, maps of the spatial

  5. Landscape and land use history of Eurajoki between 1840 and 2007: Analysis of geographical data and landscape transformation; Eurajoen maisema- ja maankaeyttoehistoria 1840-2007: paikkatietoaineistojen kaesittely ja muutosten kartoitus

    Energy Technology Data Exchange (ETDEWEB)

    Koistinen, T.; Kaeyhkoe, N. [Turku Univ. (Finland), Dept. of Geography and Geology, Lab. of Computer Cartography

    2011-11-15

    , vectorizing of the selected elements, standardizing of the heterogeneous spatial data and analyzing and estimating of the quality of the produced data. In addition report includes description of used landscape change study methods and visualizations of the produced spatial data and change analysis results. The future possibilities and restrictions of the data are also discussed. Main challenges for the use are thematic differencies and inconsistencies between the original map products. Different scales and geometric errors cause also some concerns for the future use. The spatial data produced from the more general map products can however turn out to be useful for example as approaching maps. The time scale of the study starts from the 1840's and ends in 2007. The maps used in this project turned out to be very varying in their consistency and reliability. This alternation was evident also between the landscape elements. Fields, meadows and buildings were depicted in the most consistent manner between the maps, altough meadow as a concept has somewhat changed during the research period. Most of the meadows in Eurajoki disappeared by the 1903-1904 as most of them were ploughed into fields. Measuring the changes in small lakes between the historical spatial data and the modern land use information was more challenging as precision of depiction was so different between the products. Comparing wetlands was also very difficult task because the way of classifying and depicting of them varied from one historical map to another. The basic structure of settlements has maintained during the whole study period although the housing in different parts of the municipal has somewhat changed it's emphasis. The basic composition of roadnetwork has also remained throughout the study period. The only clear new feature in the landscape is the highway that was built in 1950's. (orig.)

  6. Industrious Landscaping

    DEFF Research Database (Denmark)

    Brichet, Nathalia Sofie; Hastrup, Frida

    2017-01-01

    This article offers a history of landscaping at Søby brown coal beds – a former mining site in western Denmark. Exploring this industrial landscape through a series of projects that have made different natural resources appear, we argue that what is even recognized as resources shifts over time...... according to radically different and unpredictable agendas. Natural resources emerge as feats of particular political and historical landscape configurations, rather than fixed dormant sediments waiting to be exploited. This indicates that the Søby landscape is fundamentally volatile, as its resourcefulness...... such as Søby both natural resources and historical developments are made through particular ad hoc perspectives, somehow providing their own argument on the basis of the ends they are seen to meet.. This view of natural resources and development processes as perspectival accomplishments calls for a detailed...

  7. Fitness club

    CERN Multimedia

    Fitness club

    2011-01-01

    General fitness Classes Enrolments are open for general fitness classes at CERN taking place on Monday, Wednesday, and Friday lunchtimes in the Pump Hall (building 216). There are shower facilities for both men and women. It is possible to pay for 1, 2 or 3 classes per week for a minimum of 1 month and up to 6 months. Check out our rates and enrol at: http://cern.ch/club-fitness Hope to see you among us! CERN Fitness Club fitness.club@cern.ch  

  8. Electromagnetic Landscape

    DEFF Research Database (Denmark)

    Cermak, Daniel; Okutsu, Ayaka; Jørgensen, Stina Marie Hasse

    2015-01-01

    Daniel Cermak-Sassenrath, Ayaka Okutsu, Stina Hasse. Electromagnetic Landscape - In-between Signal, Noise and Environment. Installation and artist talk. 21th International Symposium on Electronic Art (ISEA) 2015, Vancouver, CAN, Aug 14-18, 2015.......Daniel Cermak-Sassenrath, Ayaka Okutsu, Stina Hasse. Electromagnetic Landscape - In-between Signal, Noise and Environment. Installation and artist talk. 21th International Symposium on Electronic Art (ISEA) 2015, Vancouver, CAN, Aug 14-18, 2015....

  9. FIT3D: Fitting optical spectra

    Science.gov (United States)

    Sánchez, S. F.; Pérez, E.; Sánchez-Blázquez, P.; González, J. J.; Rosales-Ortega, F. F.; Cano-Díaz, M.; López-Cobá, C.; Marino, R. A.; Gil de Paz, A.; Mollá, M.; López-Sánchez, A. R.; Ascasibar, Y.; Barrera-Ballesteros, J.

    2016-09-01

    FIT3D fits optical spectra to deblend the underlying stellar population and the ionized gas, and extract physical information from each component. FIT3D is focused on the analysis of Integral Field Spectroscopy data, but is not restricted to it, and is the basis of Pipe3D, a pipeline used in the analysis of datasets like CALIFA, MaNGA, and SAMI. It can run iteratively or in an automatic way to derive the parameters of a large set of spectra.

  10. Algorithm of athletes’ fitness structure individual features’ determination with the help of multidimensional analysis (on example of basketball

    Directory of Open Access Journals (Sweden)

    Zh.L. Kozina

    2017-10-01

    Full Text Available Purpose: to determine main laws of determination of athletes’ fitness structure’s individual characteristics with the help of multidimensional analysis (on example of basketball. Material: in the research elite basketball players (n=54 participated. Pedagogic testing included 12 tests, applied in combined teams of Ukraine and Russia. For every test three attempts were given and the best result was registered. The tests were passed during 2-3 training sessions. Results: we worked out general scheme of ways of athletes’ training individualization. For every athlete we determined the groups of leading and secondary factors in individual structure of fitness. The process of athletes’ training shall contain basic and variable components. Basic component was 70% of means in general system of athletes' training. Variable component was 30% of means and implies application of individual training means. Percentage of means in individual programs varies depending on the following: leading factors in fitness individual structure; period of individual dynamic of competition efficiency. In every micro-cycle 30% is assigned for athletes’ individual training: athletes received individual tasks; groups on the base of cluster analysis data were formed, if necessary. Conclusions: when working out individual training programs, development of leading factors in individual factorial structure of athletes’ fitness shall be accented. Application of individual programs, combined with universal individualization methods creates preconditions for rising competition activities’ efficiency.

  11. The Impact Analysis of Water Body Landscape Pattern on Urban Heat Island: A Case Study of Wuhan City

    Directory of Open Access Journals (Sweden)

    Bohan Yang

    2015-01-01

    Full Text Available Based on the LST and the landscape metrics of water body with remote sensing technique and spatial analysis, the relationship between the mean LST and the attributes of water body was revealed via Pearson’s correlation analysis and multiple stepwise regression analysis. Result showed that, in 32 class-based metrics we selected, the proportion of water body, average water body size, the isolation and fragmentation of water body, and other eight metrics have high correlation with the LST. As a resultant force, the quantity, shape, and spatial distribution of water body affect the forming of temperature. We found that the quantity and spatial pattern of city water body could be allocated reasonably to maximize its cooling effect.

  12. Analysis of the effects of agricultural land use change on rural environment and landscape through historical cartography and GIS tools

    Directory of Open Access Journals (Sweden)

    Dina Statuto

    2016-03-01

    Full Text Available The human activities and the social and economic transformations occurred during the last century led modifications in the agro-forestry areas. This paper shows a study case study in which the dynamics of land use are analysed using a geographic information system applied to historical maps in order to evaluate the consequences of these land transformations over the last 179 years on the rural environment and landscape. The use of three-dimensional reconstructions, obtained through the creation of different digital terrain model, has allowed to appreciate the landscape modifications, in term of morphological and vegetation variation, determining its aesthetic quality. The analysis shows a common dynamic present in many rural areas of Southern Italy, i.e., the increase of agricultural areas replacing forested surfaces in an older period followed by the further phenomenon of spontaneous re-naturalisation of many of these areas, due to the abandonment of extensive cultivated areas. Moreover, through comparison with historical documents, it was possible to analyse how the agricultural activities influenced the quality of the forest ecosystem. The methodology employed in this study allows a detailed analysis of the processes that occurred in different rural context and the creation of appropriate tools for sustainable land management.

  13. On the Usefulness of a Multilevel Logistic Regression Approach to Person-Fit Analysis

    Science.gov (United States)

    Conijn, Judith M.; Emons, Wilco H. M.; van Assen, Marcel A. L. M.; Sijtsma, Klaas

    2011-01-01

    The logistic person response function (PRF) models the probability of a correct response as a function of the item locations. Reise (2000) proposed to use the slope parameter of the logistic PRF as a person-fit measure. He reformulated the logistic PRF model as a multilevel logistic regression model and estimated the PRF parameters from this…

  14. Testing Hypotheses About the Person-Response Function in Person-Fit Analysis

    NARCIS (Netherlands)

    Emons, Wilco H.M.; Sijtsma, Klaas; Meijer, R.R.

    The person-response function (PRF) relates the probability of an individual's correct answer to the difficulty of items measuring the same latent trait. Local deviations of the observed PRF from the expected PRF indicate person misfit. We discuss two new approaches to investigate person fit. The

  15. An analysis of weight loss articles and advertisements inmainstream women’s health and fitness magazines

    Directory of Open Access Journals (Sweden)

    Danna Ethan

    2016-06-01

    Conclusion: Articles presented information about exercise and dieting whereas advertisements supported potentially harmful health beliefs and behaviors. As a well-utilized American media format, health and fitness-focused magazines have an opportunity to communicate frequent,accurate messaging about healthy weight reduction and limit advertisements that may include misleading claims.

  16. Oxygen mask fit analysis in F-16 fighter pilots using 3D imaging

    NARCIS (Netherlands)

    Schreinemakers, J.R.C.; Oudenhuijzen, A.J.K.; Amerongen, P.C.G.M. van; Kon, M.

    2013-01-01

    Background: The majority of Dutch F-16 pilots experience in-flight oxygen mask related nasal discomfort and injury. We aimed to analyze the fit of the oxygen mask. Methods: We successfully scanned 35 pilots with a 3D scanner to measure the distance between the contact area on the nose and the oxygen

  17. On the Usefulness of a Multilevel Logistic Regression Approach to Person-Fit Analysis

    Science.gov (United States)

    Conijn, Judith M.; Emons, Wilco H. M.; van Assen, Marcel A. L. M.; Sijtsma, Klaas

    2011-01-01

    The logistic person response function (PRF) models the probability of a correct response as a function of the item locations. Reise (2000) proposed to use the slope parameter of the logistic PRF as a person-fit measure. He reformulated the logistic PRF model as a multilevel logistic regression model and estimated the PRF parameters from this…

  18. Oxygen mask fit analysis in F-16 fighter pilots using 3D imaging

    NARCIS (Netherlands)

    Schreinemakers, J.R.C.; Oudenhuijzen, A.J.K.; Amerongen, P.C.G.M. van; Kon, M.

    2013-01-01

    Background: The majority of Dutch F-16 pilots experience in-flight oxygen mask related nasal discomfort and injury. We aimed to analyze the fit of the oxygen mask. Methods: We successfully scanned 35 pilots with a 3D scanner to measure the distance between the contact area on the nose and the oxygen

  19. Testing Hypotheses About the Person-Response Function in Person-Fit Analysis

    NARCIS (Netherlands)

    Emons, Wilco H.M.; Sijtsma, Klaas; Meijer, Rob R.

    2004-01-01

    The person-response function (PRF) relates the probability of an individual's correct answer to the difficulty of items measuring the same latent trait. Local deviations of the observed PRF from the expected PRF indicate person misfit. We discuss two new approaches to investigate person fit. The fir

  20. Perception of physical fitness is associated with perception of body weight: sociodemographic analysis in Spain

    Directory of Open Access Journals (Sweden)

    Carlos Mª Tejero-González

    2014-02-01

    Full Text Available Introduction: The objective of this study was to analyse the relationship between sociodemographic characteristics, body weight perception and physical fitness perception. Methods: Survey by means of personal interview. The sample consisted of 8,594 participants living in Spain between 15 and 97 years of age. Sampling error was ±1.07%. Results: Of the people who reported having good or excellent physical fitness, there was a proportionally greater prevalence of males, people aged 15 to 34, people with university studies and people from an upper or very upper social class (P < 0.001. It was also inferred that there was a greater possibility of perceiving deficient or very bad physical fitness in cohorts who felt that they should gain a bit of weight (OR = 2.87, lose a bit of weight (OR = 2.31 or lose a lot of weight (OR = 8.78. Conclusion: Perception of physical fitness is associated with perception of body weight, independently of people's sociodemographic characteristics.

  1. Chapter 4: Overview of the vegetation management treatment economic analysis module in the integrated landscape assessment project

    Science.gov (United States)

    Xiaoping Zhou; Miles A. Hemstrom

    2014-01-01

    Forest land provides various ecosystem services, including timber, biomass, and carbon sequestration. Estimating trends in these ecosystem services is essential for assessing potential outcomes of landscape management scenarios. However, the state-and transition models used in the Integrated Landscape Assessment Project for simulating landscape changes over time do not...

  2. Do anti-embolism stockings fit our legs? Leg survey and data analysis.

    Science.gov (United States)

    Macintyre, Lisa; Kent, Kimberly; McPhee, Donna

    2013-07-01

    Anti-embolism stockings are commonly used worldwide to prevent the development of thrombosis in hospitalised patients. Patients are typically measured for, and fitted with, anti-embolism stockings during extended periods of non-ambulation. Anti-embolism stockings must critically fit the leg to achieve optimum blood flow and thus success of prophylaxis. Therefore, hospitals endeavour to maintain stock of anti-embolism stockings that fit the majority of their patients. The objective of this study was to establish whether popular styles/brands of anti-embolism stockings "fitted" the legs of convenience sampled volunteers. Volunteer's legs were measured at ankle, calf and thigh following guidance from British nurses and in accordance with brand instructions. Leg measurements were subsequently compared to the size charts of 10 anti-embolism stocking styles made by 4 different manufacturers. "Fit" is defined as a volunteer's leg measurements matching any stocking size in a range at all measurement points. Volunteers were measured in different settings around Scotland, including private homes, work places and shopping centres. A convenience sample of 471 volunteers (283 female, 188 male) were recruited on the basis of willingness to participate and being over 16 years old. Volunteers ranged from 17 years to 82 years old with an average age of 35. The 10 different styles of anti-embolism stockings, made by 4 different brands, examined for this paper had a size match coefficient ranging from 0% to 100% for our volunteer's legs. The size match coefficient is strongly influenced by the Brand's sizing policy. The proportion of legs that "fit" a particular brand of anti-embolism stockings can be increased through: (1) the reduction of the number of leg measurement points that need to be matched to the size chart of the stockings; (2) the use of open-ended size ranges; (3) the use of increased size range width and (4) the use of increased overlap between sizes. However, all but

  3. Cardiovascular risk profile: Cross-sectional analysis of motivational determinants, physical fitness and physical activity

    Directory of Open Access Journals (Sweden)

    Kiers Henri

    2010-10-01

    Full Text Available Abstract Background Cardiovascular risk factors are associated with physical fitness and, to a lesser extent, physical activity. Lifestyle interventions directed at enhancing physical fitness in order to decrease the risk of cardiovascular diseases should be extended. To enable the development of effective lifestyle interventions for people with cardiovascular risk factors, we investigated motivational, social-cognitive determinants derived from the Theory of Planned Behavior (TPB and other relevant social psychological theories, next to physical activity and physical fitness. Methods In the cross-sectional Utrecht Police Lifestyle Intervention Fitness and Training (UP-LIFT study, 1298 employees (aged 18 to 62 were asked to complete online questionnaires regarding social-cognitive variables and physical activity. Cardiovascular risk factors and physical fitness (peak VO2 were measured. Results For people with one or more cardiovascular risk factors (78.7% of the total population, social-cognitive variables accounted for 39% (p In addition to the prediction of intention to engage in physical activity and physical active behavior, we explored the impact of the intensity of physical activity. The intentsity of physical activity was only significantly related to physical active behavior (beta = .253, p 2 = .06, p 2 = .23, p For people with one or more cardiovascular risk factors, 39.9% had positive intentions to engage in physical activity and were also physically active, and 10.5% had a low intentions but were physically active. 37.7% had low intentions and were physically inactive, and about 11.9% had high intentions but were physically inactive. Conclusions This study contributes to our ability to optimize cardiovascular risk profiles by demonstrating an important association between physical fitness and social-cognitive variables. Physical fitness can be predicted by physical active behavior as well as by self-efficacy and the intensity of

  4. An analysis of weight loss articles and advertisements in mainstream women's health and fitness magazines.

    Science.gov (United States)

    Ethan, Danna; Basch, Corey H; Hillyer, Grace Clarke; Berdnik, Alyssa; Huynh, Mary

    2016-01-01

    Magazines are a commonly used source for health and fitness information. Little is known about the nature and extent of weight loss strategies and products presented in mainstream women's health and fitness magazines. This preliminary cross-sectional study evaluated the prevalence of articles and advertisements featuring weight loss content and products in mainstream US-based health and fitness magazines, as well as assessed weight loss themes presented. Thirty-one US health and fitness-focused magazine issues were coded. Prevalence of, product type, and themes related to weight loss in articles and advertisements were assessed. Among the 31 issues of the five US-based women's magazines examined, we identified 39 articles (4.8% [95% CI = 3.3% to 5.5%] of 819 articles) related to weight loss with 14 identified weight loss topics. The most prevalent article topics covered were exercising/workouts (32.0% [95% CI = 28.8% to 33.6%]) followed by dieting (18.6% [95% CI = 15.9% to 19.9%]).The most common product advertised was weight loss pills (46.0% [95% CI = 42.6% to 47.7%]). Fat burners were also frequently advertised (14.9% [95% CI = 12.5% to 16.1%]) followed by hunger reduction strategies (10.3% [95% CI = 8.2% to 11.3%]) and fat blockers (6.9% [95% CI= 5.2% to 7.8%]). Articles presented information about exercise and dieting whereas advertisements supported potentially harmful health beliefs and behaviors. As a well-utilized American media format, health and fitness-focused magazines have an opportunity to communicate frequent,accurate messaging about healthy weight reduction and limit advertisements that may include misleading claims.

  5. Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme.

    Science.gov (United States)

    Honaker, Matthew T; Acchione, Mauro; Sumida, John P; Atkins, William M

    2011-12-09

    Enzymological paradigms have shifted recently to acknowledge the biological importance of catalytic promiscuity. However, catalytic promiscuity is a poorly understood property, and no thermodynamic treatment has described the conformational landscape of promiscuous versus substrate-specific enzymes. Here, two structurally similar glutathione transferase (GST, glutathione S-transferase) isoforms with high specificity or high promiscuity are compared. Differential scanning calorimetry (DSC) indicates a reversible low temperature transition for the promiscuous GSTA1-1 that is not observed with substrate-specific GSTA4-4. This transition is assigned to rearrangement of the C terminus at the active site of GSTA1-1 based on the effects of ligands and mutations. Near-UV and far-UV circular dichroism indicate that this transition is due to repacking of tertiary contacts with the remainder of the subunit, rather than "unfolding" of the C terminus per se. Analysis of the DSC data using a modified Landau theory indicates that the local conformational landscape of the active site of GSTA1-1 is smooth, with barrierless transitions between states. The partition function of the C-terminal states is a broad unimodal distribution at all temperatures within this DSC transition. In contrast, the remainder of the GSTA1-1 subunit and the GSTA4-4 protein exhibit folded and unfolded macrostates with a significant energy barrier separating them. Their partition function includes a sharp unimodal distribution of states only at temperatures that yield either folded or unfolded macrostates. At intermediate temperatures the partition function includes a bimodal distribution. The barrierless rearrangement of the GSTA1-1 active site within a local smooth energy landscape suggests a thermodynamic basis for catalytic promiscuity.

  6. A simple approach for a spatial terrestrial exposure assessment of the insecticide fenoxycarb, based on a high-resolution landscape analysis.

    Science.gov (United States)

    Thomas, Kai; Resseler, Herbert; Spatz, Robert; Hendley, Paul; Sweeney, Paul; Urban, Martin; Kubiak, Roland

    2016-11-01

    The objective was to refine the standard regulatory exposure scenario used in plant protection product authorisations by developing a more realistic landscape-related GIS-based exposure assessment for terrestrial non-target arthropods. We quantified the proportion of adjacent off-target area in agricultural landscapes potentially exposed to insecticide drift from applications of the active substance fenoxycarb. High-resolution imagery, landscape classification and subsequent stepwise analysis of a whole landscape using drift and interception functions were applied to selected areas in representative fruit-producing regions in Germany. Even under worst-case assumptions regarding treated area, use rate and drift, less than 12% of the non-agricultural habitat area would potentially be exposed to fenoxycarb drift above regulatory acceptable concentrations. Additionally, if the filtering effect of tall vegetation were taken into account, this number would decrease to 6.6%. Further refinements to landscape elements and application conditions indicate that less than 5% of the habitat area might be exposed above regulatory acceptable concentrations, meaning that 95% of the non-agricultural habitat area will be unimpacted (i.e. no unacceptable effects) and can serve as refuge for recolonisation. Approaches and tools are proposed for standardisable and transparent refinements in regulatory risk assessments on the landscape level. © 2016 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. © 2016 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

  7. Cardiovascular risk profile: cross-sectional analysis of motivational determinants, physical fitness and physical activity.

    Science.gov (United States)

    Sassen, Barbara; Kok, Gerjo; Schaalma, Herman; Kiers, Henri; Vanhees, Luc

    2010-10-07

    Cardiovascular risk factors are associated with physical fitness and, to a lesser extent, physical activity. Lifestyle interventions directed at enhancing physical fitness in order to decrease the risk of cardiovascular diseases should be extended. To enable the development of effective lifestyle interventions for people with cardiovascular risk factors, we investigated motivational, social-cognitive determinants derived from the Theory of Planned Behavior (TPB) and other relevant social psychological theories, next to physical activity and physical fitness. In the cross-sectional Utrecht Police Lifestyle Intervention Fitness and Training (UP-LIFT) study, 1298 employees (aged 18 to 62) were asked to complete online questionnaires regarding social-cognitive variables and physical activity. Cardiovascular risk factors and physical fitness (peak VO2) were measured. For people with one or more cardiovascular risk factors (78.7% of the total population), social-cognitive variables accounted for 39% (p < .001) of the variance in the intention to engage in physical activity for 60 minutes every day. Important correlates of intention to engage in physical activity were attitude (beta = .225, p < .001), self-efficacy (beta = .271, p < .001), descriptive norm (beta = .172, p < .001) and barriers (beta = -.169, p < .01). Social-cognitive variables accounted for 52% (p < .001) of the variance in physical active behaviour (being physical active for 60 minutes every day). The intention to engage in physical activity (beta = .469, p < .001) and self-efficacy (beta = .243, p < .001) were, in turn, important correlates of physical active behavior.In addition to the prediction of intention to engage in physical activity and physical active behavior, we explored the impact of the intensity of physical activity. The intensity of physical activity was only significantly related to physical active behavior (beta = .253, p < .01, R2 = .06, p < .001). An important goal of our study was to

  8. 流域景观格局分析研究进展%Progress of analysis and research on landscape pattern of river basin

    Institute of Scientific and Technical Information of China (English)

    张爱静; 董哲仁; 赵进勇; 孙东亚

    2012-01-01

    Landscape pattern analysis is an effective method for assessment of ecological status and explication of ecological process. The progress of the research on the interrelations between landscape pattern of river basin and ecological process is emphatically expounded herein on the basis of introducing the relevant landscape pattern analysis methods, and then the generals of the study on the coupling between landscape pattern and ecological process are also presented by taking the PLM model as a typical study case. Finally, the applications of landscape pattern analysis to land-use planning, ecological assessment and river ecological restoration are discussed as well%景观格局分析是评估生态状况、诠释生态过程的有效工具.本文在介绍流域景观格局分析方法的基础上,重点阐述了流域景观格局与生态过程之间相互关系的研究进展,并以PLM景观模型为例,论述了景观格局与生态过程耦合研究的概况.最后,文中还讨论了流域景观格局分析在土地利用规划、生态状况评估、河流生态修复中的应用.

  9. Landscape analysis as a theoretical-methodological tool and bridge for territory socio-environmental management

    Directory of Open Access Journals (Sweden)

    Susana Barrera Lobatón

    2013-12-01

    Full Text Available This paper attempts to understand how the concept of landscape is transformed from its academic production and discussion to its adaptation by the State; and also how this concept ends up being applied on the territory by various professionals interested in it. In order to do this we look at some definitions developed by various disciplines: Geography, Anthropology, Archeology, Ecology, Agronomy and Architecture, highlighting key points; and we make a comparison between their proposals and the way these concepts have been adopted by the State, specifically through the so-called “terms of reference”. Then we analyze how these concepts and methodologies are put into practice by professionals working in different consulting companies, many times disregarding how local inhabitants understand and live the landscape from their territory. We conclude that there is a clear need to build bridges between the Academia, the State, the people and the business sector, through professional practice and based on the need to acknowledge the way local inhabitants live the concept from their territory. Only in this way will we manage to make a real impact and better people’s life quality.

  10. Landscape-scale analysis of aboveground tree carbon stocks affected by mountain pine beetles in Idaho

    Science.gov (United States)

    Bright, B. C.; Hicke, J. A.; Hudak, A. T.

    2012-12-01

    Bark beetle outbreaks kill billions of trees in western North America, and the resulting tree mortality can significantly impact local and regional carbon cycling. However, substantial variability in mortality occurs within outbreak areas. Our objective was to quantify landscape-scale effects of beetle infestations on aboveground carbon (AGC) stocks using field observations and remotely sensed data across a 5054 ha study area that had experienced a mountain pine beetle outbreak. Tree mortality was classified using multispectral imagery that separated green, red, and gray trees, and models relating field observations of AGC to LiDAR data were used to map AGC. We combined mortality and AGC maps to quantify AGC in beetle-killed trees. Thirty-nine per cent of the forested area was killed by beetles, with large spatial variability in mortality severity. For the entire study area, 40-50% of AGC was contained in beetle-killed trees. When considered on a per-hectare basis, 75-89% of the study area had >25% AGC in killed trees and 3-6% of the study area had >75% of the AGC in killed trees. Our results show that despite high variability in tree mortality within an outbreak area, bark beetle epidemics can have a large impact on AGC stocks at the landscape scale.

  11. A detailed analysis of the recombination landscape of the button mushroom Agaricus bisporus var. bisporus.

    Science.gov (United States)

    Sonnenberg, Anton S M; Gao, Wei; Lavrijssen, Brian; Hendrickx, Patrick; Sedaghat-Tellgerd, Narges; Foulongne-Oriol, Marie; Kong, Won-Sik; Schijlen, Elio G W M; Baars, Johan J P; Visser, Richard G F

    2016-08-01

    The button mushroom (Agaricus bisporus) is one of the world's most cultivated mushroom species, but in spite of its economic importance generation of new cultivars by outbreeding is exceptional. Previous genetic analyses of the white bisporus variety, including all cultivars and most wild isolates revealed that crossing over frequencies are low, which might explain the lack of introducing novel traits into existing cultivars. By generating two high quality whole genome sequence assemblies (one de novo and the other by improving the existing reference genome) of the first commercial white hybrid Horst U1, a detailed study of the crossover (CO) landscape was initiated. Using a set of 626 SNPs in a haploid offspring of 139 single spore isolates and whole genome sequencing on a limited number of homo- and heterokaryotic single spore isolates, we precisely mapped all COs showing that they are almost exclusively restricted to regions of about 100kb at the chromosome ends. Most basidia of A. bisporus var. bisporus produce two spores and pair preferentially via non-sister nuclei. Combined with the COs restricted to the chromosome ends, these spores retain most of the heterozygosity of the parent thus explaining how present-day white cultivars are genetically so close to the first hybrid marketed in 1980. To our knowledge this is the first example of an organism which displays such specific CO landscape.

  12. Biomechanics of the press-fit phenomenon in dental implantology: an image-based finite element analysis

    OpenAIRE

    Frisardi Gianni; Barone Sandro; Razionale Armando V; Paoli Alessandro; Frisardi Flavio; Tullio Antonio; Lumbau Aurea; Chessa Giacomo

    2012-01-01

    Abstract Background A fundamental pre-requisite for the clinical success in dental implant surgery is the fast and stable implant osseointegration. The press-fit phenomenon occurring at implant insertion induces biomechanical effects in the bone tissues, which ensure implant primary stability. In the field of dental surgery, the understanding of the key factors governing the osseointegration process still remains of utmost importance. A thorough analysis of the biomechanics of dental implanto...

  13. Marginal fit and photoelastic stress analysis of CAD-CAM and overcast 3-unit implant-supported frameworks.

    Science.gov (United States)

    Presotto, Anna Gabriella Camacho; Bhering, Cláudia Lopes Brilhante; Mesquita, Marcelo Ferraz; Barão, Valentim Adelino Ricardo

    2017-03-01

    Several studies have shown the superiority of computer-assisted design and computer-assisted manufacturing (CAD-CAM) technology compared with conventional casting. However, an advanced technology exists for casting procedures (the overcasting technique), which may serve as an acceptable and affordable alternative to CAD-CAM technology for fabricating 3-unit implant-supported fixed dental prostheses (FDPs). The purpose of this in vitro study was to evaluate, using quantitative photoelastic analysis, the effect of the prosthetic framework fabrication method (CAD-CAM and overcasting) on the marginal fit and stress transmitted to implants. The correlation between marginal fit and stress was also investigated. Three-unit implant-supported FDP frameworks were made using the CAD-CAM (n=10) and overcasting (n=10) methods. The frameworks were waxed to simulate a mandibular first premolar (PM region) to first molar (M region) FDP using overcast mini-abutment cylinders. The wax patterns were overcast (overcast experimental group) or scanned to obtain the frameworks (CAD-CAM control group). All frameworks were fabricated from cobalt-chromium (CoCr) alloy. The marginal fit was analyzed according to the single-screw test protocol, obtaining an average value for each region (M and PM) and each framework. The frameworks were tightened for the photoelastic model with standardized 10-Ncm torque. Stress was measured by quantitative photoelastic analysis. The results were submitted to the Student t test, 2-way ANOVA, and Pearson correlation test (α=.05). The framework fabrication method (FM) and evaluation site (ES; M and PM regions) did not affect the marginal fit values (P=.559 for FM and P=.065 for ES) and stress (P=.685 for FM and P=.468 for ES) in the implant-supported system. Positive correlations between marginal fit and stress were observed (CAD-CAM: r=0.922; PCAD-CAM and overcasting methods present similar marginal fit and stress values for 3-unit FDP frameworks. The

  14. Fitness Club

    CERN Multimedia

    Fitness Club

    2011-01-01

    The CERN Fitness Club is organising Zumba Classes on the first Wednesday of each month, starting 7 September (19.00 – 20.00). What is Zumba®? It’s an exhilarating, effective, easy-to-follow, Latin-inspired, calorie-burning dance fitness-party™ that’s moving millions of people toward joy and health. Above all it’s great fun and an excellent work out. Price: 22 CHF/person Sign-up via the following form: https://espace.cern.ch/club-fitness/Lists/Zumba%20Subscription/NewForm.aspx For more info: fitness.club@cern.ch

  15. Globalization and Landscape Architecture

    Directory of Open Access Journals (Sweden)

    Robert R. Hewitt

    2014-02-01

    Full Text Available The literature review examines globalization and landscape architecture as discourse, samples its various meanings, and proposes methods to identify and contextualize its specific literature. Methodologically, the review surveys published articles and books by leading authors and within the WorldCat.org Database associated with landscape architecture and globalization, analyzing survey results for comprehensive conceptual and co-relational frameworks. Three “higher order” dimensions frame the review’s conceptual organization, facilitating the organization of subordinate/subtopical areas of interest useful for comparative analysis. Comparative analysis of the literature suggests an uneven clustering of discipline-related subject matter across the literature’s “higher order” dimensions, with a much smaller body of literature related to landscape architecture confined primarily to topics associated with the dispersion of global phenomena. A subcomponent of this smaller body of literature is associated with other fields of study, but inferentially related to landscape architecture. The review offers separate references and bibliographies for globalization literature in general and globalization and landscape architecture literature, specifically.

  16. Geometry and Coarse-Grained Representations of Landscapes

    DEFF Research Database (Denmark)

    Qin, Jing; Stadler, Peter; Klemm, Konstantin

    2014-01-01

    Recent Advances in the Theory and Application of Fitness Landscapes Emergence, Complexity and ComputationVolume 6, 2014, pp 153-176......Recent Advances in the Theory and Application of Fitness Landscapes Emergence, Complexity and ComputationVolume 6, 2014, pp 153-176...

  17. Detecting the Land-Cover Changes Induced by Large-Physical Disturbances Using Landscape Metrics, Spatial Sampling, Simulation and Spatial Analysis

    Directory of Open Access Journals (Sweden)

    Hone-Jay Chu

    2009-08-01

    Full Text Available The objectives of the study are to integrate the conditional Latin Hypercube Sampling (cLHS, sequential Gaussian simulation (SGS and spatial analysis in remotely sensed images, to monitor the effects of large chronological disturbances on spatial characteristics of landscape changes including spatial heterogeneity and variability. The multiple NDVI images demonstrate that spatial patterns of disturbed landscapes were successfully delineated by spatial analysis such as variogram, Moran’I and landscape metrics in the study area. The hybrid method delineates the spatial patterns and spatial variability of landscapes caused by these large disturbances. The cLHS approach is applied to select samples from Normalized Difference Vegetation Index (NDVI images from SPOT HRV images in the Chenyulan watershed of Taiwan, and then SGS with sufficient samples is used to generate maps of NDVI images. In final, the NDVI simulated maps are verified using indexes such as the correlation coefficient and mean absolute error (MAE. Therefore, the statistics and spatial structures of multiple NDVI images present a very robust behavior, which advocates the use of the index for the quantification of the landscape spatial patterns and land cover change. In addition, the results transferred by Open Geospatial techniques can be accessed from web-based and end-user applications of the watershed management.

  18. Dynamic landscape models of coevolutionary games

    CERN Document Server

    Richter, Hendrik

    2016-01-01

    Players of coevolutionary games may update not only their strategies but also their networks of interaction. Based on interpreting the payoff of players as fitness, dynamic landscape models are proposed. The modeling procedure is carried out for Prisoner's Dilemma (PD) and Snowdrift (SD) games that both use either birth-death (BD) or death-birth (DB) strategy updating. With the main focus on using dynamic fitness landscapes as an alternative tool for analyzing coevolutionary games, landscape measures such as modality, ruggedness and information content are computed and analyzed. In addition, fixation properties of the games and quantifiers characterizing the network of interaction are calculated numerically. Relations are established between landscape properties expressed by landscape measures and quantifiers of coevolutionary game dynamics such as fixation probabilities, fixation times and network properties

  19. Computation of mutual fitness by competing bacteria

    NARCIS (Netherlands)

    Keymer, J.E.; Galajda, P.; Lambert, G.; Liao, D.; Austin, R.H.

    2008-01-01

    Competing populations in shared spaces with nonrenewable resources do not necessarily wage a battle for dominance at the cost of extinction of the less-fit strain if there are fitness advantages to the presence of the other strain. We report on the use of nanofabricated habitat landscapes to study t

  20. Computation of mutual fitness by competing bacteria

    NARCIS (Netherlands)

    Keymer, J.E.; Galajda, P.; Lambert, G.; Liao, D.; Austin, R.H.

    2008-01-01

    Competing populations in shared spaces with nonrenewable resources do not necessarily wage a battle for dominance at the cost of extinction of the less-fit strain if there are fitness advantages to the presence of the other strain. We report on the use of nanofabricated habitat landscapes to study t

  1. Quantitative analysis of the publishing landscape in High-Energy Physics

    CERN Document Server

    Mele, S; Vigen, Jens; Yeomans, Joanne

    2006-01-01

    World-wide collaboration in high-energy physics (HEP) is a tradition which dates back several decades, with scientific publications mostly coauthored by scientists from different countries. This coauthorship phenomenon makes it difficult to identify precisely the "share" of each country in HEP scientific production. One year's worth of HEP scientific articles published in peer-reviewed journals is analysed and their authors are uniquely assigned to countries. This method allows the first correct estimation on a pro rata basis of the share of HEP scientific publishing among several countries and institutions. The results provide an interesting insight into the geographical collaborative patterns of the HEP community. The HEP publishing landscape is further analysed to provide information on the journals favoured by the HEP community and on the geographical variation of their author bases. These results provide quantitative input to the ongoing debate on the possible transition of HEP publishing to an Open Acce...

  2. Implications of atmospheric conditions for analysis of surface temperature variability derived from landscape-scale thermography

    Science.gov (United States)

    Hammerle, Albin; Meier, Fred; Heinl, Michael; Egger, Angelika; Leitinger, Georg

    2016-08-01

    Thermal infrared (TIR) cameras perfectly bridge the gap between (i) on-site measurements of land surface temperature (LST) providing high temporal resolution at the cost of low spatial coverage and (ii) remotely sensed data from satellites that provide high spatial coverage at relatively low spatio-temporal resolution. While LST data from satellite (LSTsat) and airborne platforms are routinely corrected for atmospheric effects, such corrections are barely applied for LST from ground-based TIR imagery (using TIR cameras; LSTcam). We show the consequences of neglecting atmospheric effects on LSTcam of different vegetated surfaces at landscape scale. We compare LST measured from different platforms, focusing on the comparison of LST data from on-site radiometry (LSTosr) and LSTcam using a commercially available TIR camera in the region of Bozen/Bolzano (Italy). Given a digital elevation model and measured vertical air temperature profiles, we developed a multiple linear regression model to correct LSTcam data for atmospheric influences. We could show the distinct effect of atmospheric conditions and related radiative processes along the measurement path on LSTcam, proving the necessity to correct LSTcam data on landscape scale, despite their relatively low measurement distances compared to remotely sensed data. Corrected LSTcam data revealed the dampening effect of the atmosphere, especially at high temperature differences between the atmosphere and the vegetated surface. Not correcting for these effects leads to erroneous LST estimates, in particular to an underestimation of the heterogeneity in LST, both in time and space. In the most pronounced case, we found a temperature range extension of almost 10 K.

  3. Landscape and regional environmental analysis of the spatial distribution of hantavirus human cases in Europe

    Directory of Open Access Journals (Sweden)

    Caroline Brigitte Zeimes

    2015-03-01

    Full Text Available Background: In Europe, the most prevalent hantavirus, Puumala virus, is transmitted by bank voles and causes nephropathia epidemica in human. The European spatial distribution of nephropathia epidemica is investigated here for the first time with a rich set of environmental variables. Methods: The influence of variables at the landscape and regional level is studied through multilevel logistic regression and further information on their effects across the different European ecoregions is obtained by comparing an overall niche model (boosted regression trees with regressions by ecoregion. Results: The presence of nephropathia epidemica is likely in populated regions with well-connected forests, more intense vegetation activity, low soil water content, mild summers and cold winters. In these regions, landscapes with a higher proportion of built-up areas in forest ecotones and lower minimum temperature in winter are expected to be more at risk. Climate and forest connectivity have a stronger effect at the regional level. If variables are staying at their current values, the models predict that nephropathia epidemica may know intensification but should not spread (although Southern Sweden, the Norwegian coast and the Netherlands should be kept under watch.Conclusions: Models indicate that large-scale modeling can lead to a very high predictive power. At large scale, the effect of one variable on disease may follow three response scenarios: the effect may be the same across the entire study area; the effect can change according to the variable value, and the effect can change depending on local specificities. Each of these scenarios impacts large-scale modeling differently.

  4. Implications of atmospheric conditions for analysis of surface temperature variability derived from landscape-scale thermography.

    Science.gov (United States)

    Hammerle, Albin; Meier, Fred; Heinl, Michael; Egger, Angelika; Leitinger, Georg

    2017-04-01

    Thermal infrared (TIR) cameras perfectly bridge the gap between (i) on-site measurements of land surface temperature (LST) providing high temporal resolution at the cost of low spatial coverage and (ii) remotely sensed data from satellites that provide high spatial coverage at relatively low spatio-temporal resolution. While LST data from satellite (LSTsat) and airborne platforms are routinely corrected for atmospheric effects, such corrections are barely applied for LST from ground-based TIR imagery (using TIR cameras; LSTcam). We show the consequences of neglecting atmospheric effects on LSTcam of different vegetated surfaces at landscape scale. We compare LST measured from different platforms, focusing on the comparison of LST data from on-site radiometry (LSTosr) and LSTcam using a commercially available TIR camera in the region of Bozen/Bolzano (Italy). Given a digital elevation model and measured vertical air temperature profiles, we developed a multiple linear regression model to correct LSTcam data for atmospheric influences. We could show the distinct effect of atmospheric conditions and related radiative processes along the measurement path on LSTcam, proving the necessity to correct LSTcam data on landscape scale, despite their relatively low measurement distances compared to remotely sensed data. Corrected LSTcam data revealed the dampening effect of the atmosphere, especially at high temperature differences between the atmosphere and the vegetated surface. Not correcting for these effects leads to erroneous LST estimates, in particular to an underestimation of the heterogeneity in LST, both in time and space. In the most pronounced case, we found a temperature range extension of almost 10 K.

  5. Contemporary Danish landscape research

    DEFF Research Database (Denmark)

    Vejre, Henrik; Brandt, Jesper

    2004-01-01

    Danish landscape research blossomed during the 1990’ies thanks to several transdisciplinary research programmes involving several institutions. The main themes of the programmes encompassed Landscape change, landscape and biological diversity, nature and landscape management, use and monitoring o...

  6. Application of Vector Landscape Metrics on Landscape Pattern Analysis for Resource-Based Cities%矢量景观指数在资源型城镇景观格局分析中的应用

    Institute of Scientific and Technical Information of China (English)

    那晓东; 臧淑英; 李晓

    2011-01-01

    景观方向性是景观空间格局的重要特征,能够反映和影响景观的生态流,对于景观的异质性分析和驱动机制分析等都具有重要意义.该文将两种矢量景观指数PO和VPO应用于通过遥感影像获取的2005年大庆市城镇景观斑块,提取斑块的方向性信息,探讨其形成机理.研究结果表明,以萨尔图、让胡路、红岗区为主的油田开发区,大部分城镇景观的走向是由北向南,建成区景观的塑造主要受到油田建设的影响;以大同镇为中心的农业区景观斑块大多数为东南-西北走向,与油田开发区相比表现出明显的差异,主要特点是面积较小,且分布分散.该研究不仅丰富了矢量景观理论应用领域,而且为揭示资源型城镇景观格局的形成机理提供依据.%Pattern directionality is a key characteristic of landscape pattern. It both reileets and attects ecological flow within the landscape,and is very important for landscape heterogeneity analysis and driving mechanism analysis. The Patch Orientation and Veetorized Patch Orientation landscape pattern metrics which are developed by Shuqing Zhang are applied to extract the directional information of build-up land patches based on the Landsat TM imagery in 2005. The results show that most of the build-up land patches trends are from north to south in the oil development zone centered on saertu, Ranghulu and Honggang. The shape of build-up landscape is influenced by the built of oil field in a large extent. In contrast,most of the build-up land patches trends in agriculture area centered on Datong are from southeast to northwest or from northwest to southeast. The main characteristics of build-up landscape patches are quite small and distribute quite separately. This study rot only develops the application fields of vector landscape pattern theory but also reveals the formulation mechanisms of build-up landscape in resource-based city.

  7. Multi-temporal analysis of energetic fluxes in the Maremma (Italy landscape between XIX and XX century

    Directory of Open Access Journals (Sweden)

    Santoro A

    2010-10-01

    Full Text Available Using the energy flow account and the input/output analysis is possible to assess the “energetic sustainability” of landscape, in order to define policies as well as planning and management tools of the rural territory. The study area is the municipality of Castagneto Carducci, located on the Tuscan coastline, in the Leghorn district. The area, 14.000 hectares wide, is characterized by wooded hills in the inner part, a narrow dunal band along the coastline with mixed pine woods, and a flat area in the middle where all the major infrastructures and agricultural activities are located. The economy is based on tourism and on high quality wine production. The energy balance is not only referred to the present situation, but we have carried out the balances for the years 1832 and 1954, in order to assess the energy use evolution through the last 180 years, according to a multitemporal methodology develop for monitoring the dynamics of Tuscan landscape The energy balances examine all the energy flows result from the various activities in agriculture, forestry and animal husbandry. The study area must be considered as a close system, and we have to value the energy flows between the inside and the outside of this system, and how this energy is used inside of it. The three periods show different landscapes, due to the different socio-economic situation. In 1832 we find a traditional agricultural structure, based on large estate and on mezzadria management; in 1954 the mezzadria gives way to the diffusion of industrial agriculture and animal husbandry, while olive orchards became one of the main elements of the landscape. From the ’70s we attend at the proliferation of vineyards, and in few years Castagneto will become the area where some of the best Italian wines are produced (Sassicaia, Ornellaia. The wooded areas have undergone a dramatic change in their spatial location, specific composition, density and structure, but the extension remains the

  8. Visualization of multivariate physiological data for cardiorespiratory fitness assessment through ECG (R-peak) analysis.

    Science.gov (United States)

    Munoz, J E; Bermudez I Badia, S; Rubio, E; Cameirao, M S

    2015-01-01

    The recent rise and popularization of wearable and ubiquitous fitness sensors has increased our ability to generate large amounts of multivariate data for cardiorespiratory fitness (CRF) assessment. Consequently, there is a need to find new methods to visualize and interpret CRF data without overwhelming users. Current visualizations of CRF data are mainly tabular or in the form of stacked univariate plots. Moreover, normative data differs significantly between gender, age and activity, making data interpretation yet more challenging. Here we present a CRF assessment tool based on radar plots that provides a way to represent multivariate cardiorespiratory data from electrocardiographic (ECG) signals within its normative context. To that end, 5 parameters are extracted from raw ECG data using R-peak information: mean HR, SDNN, RMSSD, HRVI and the maximal oxygen uptake, VO2max. Our tool processes ECG data and produces a visualization of the data in a way that it is easy to compare between the performance of the user and normative data. This type of representation can assist both health professionals and non-expert users in the interpretation of CRF data.

  9. A comparative analysis on computational methods for fitting an ERGM to biological network data

    Directory of Open Access Journals (Sweden)

    Sudipta Saha

    2015-03-01

    Full Text Available Exponential random graph models (ERGM based on graph theory are useful in studying global biological network structure using its local properties. However, computational methods for fitting such models are sensitive to the type, structure and the number of the local features of a network under study. In this paper, we compared computational methods for fitting an ERGM with local features of different types and structures. Two commonly used methods, such as the Markov Chain Monte Carlo Maximum Likelihood Estimation and the Maximum Pseudo Likelihood Estimation are considered for estimating the coefficients of network attributes. We compared the estimates of observed network to our random simulated network using both methods under ERGM. The motivation was to ascertain the extent to which an observed network would deviate from a randomly simulated network if the physical numbers of attributes were approximately same. Cut-off points of some common attributes of interest for different order of nodes were determined through simulations. We implemented our method to a known regulatory network database of Escherichia coli (E. coli.

  10. Dynamic modeling and analysis of vortex filament motion using a novel curve-fitting method

    Directory of Open Access Journals (Sweden)

    Chang-Joo Kim

    2016-02-01

    Full Text Available Applications of a novel curve-fitting technique are presented to efficiently predict the motion of the vortex filament, which is trailed from a rigid body such as wings and rotors. The governing equations of the motion, when a Lagrangian approach with the present curve-fitting method is applied, can be transformed into an easily solvable form of the system of nonlinear ordinary differential equations. The applicability of Bézier curves, B-spline, and Lagrange interpolating polynomials is investigated. Local Lagrange interpolating polynomials with a shift operator are proposed as the best selection for applications, since it provides superior system characteristics with minimum computing time, compared to other methods. In addition, the Gauss quadrature formula with local refinement strategy has been developed for an accurate prediction of the induced velocity computed with the line integration of the Biot–Savart law. Rotary-wing problems including a vortex ring problem are analyzed to show the efficiency, accuracy, and flexibility in the applications of the proposed method.

  11. An analysis of certain components of health related fitness: An exploration through the practice of yoga

    Directory of Open Access Journals (Sweden)

    DR. MANJIT SINGH

    2014-10-01

    Full Text Available The purpose of this study was to determine the effects of 6-week training programme of yogic asanas on certain components of Health Related Fitness (i.e., cardiovascular endurance, body composition, muscular strength & endurance and flexibility. Data were collected on thirty (N=30 female subjects between the age group of 18-25 years (Mean ± SD: age 21.03 ± 1.30 years, body mass 63.40 ± 2.36 kg, height 1.62 ± 0.022 m from Department of Physical Education (T, Guru Nanak Dev University, Amritsar, Punjab, India. The subjects were purposively assigned into two groups: Group-A: Experimental (N1=15 and Group-B: Control (N2=15. All participants were informed about the objective and protocol of the study. The 6 week training programme of yogic asanas brought about significant improvement in cardiovascular Endurance (P<.05, Body Composition (P<.05, Muscular Strength & Endurance (p<.05 and flexibility (p<.05. It is concluded that, the 6-week training programme of yogic asanas had significant effect on cardiovascular endurance, body composition, muscular strength & endurance and flexibility. Thus, such yogic asanas may be recommended to improve aerobic fitness, percent body fat, abdominal strength & endurance and trunk flexibility.

  12. Accurate fit and thermochemical analysis of the adsorption isotherms of methane in zeolite 13X

    Energy Technology Data Exchange (ETDEWEB)

    Llano-Restrepo, M. [University of Valle, Valle (Colombia). School of Chemical Engineering

    2010-07-01

    The recovery of methane from landfill gases and coal mines has become of the utmost importance because methane has a global-climate warming potential much higher than that of carbon dioxide. Zeolite 13X is widely used for the separation of methane and carbon dioxide from such sources. Accurate fits of the adsorption isotherms of methane in zeolite 13X are required for the rigorous simulation of that separation. In this work, a generalized statistical thermodynamic adsorption (GSTA) model has been used to obtain a very accurate correlation of a published set of adsorption isotherms of methane in zeolite 13X that were measured from 120 K to 273 K over the pressure range 0.07 Pa to 12.2 MPa. In contrast, none of five traditional adsorption models was capable of fitting these isotherms. A thermochemical interpretation of the correlation is provided and predictions for the isosteric heat of adsorption are made, which turn out to be in excellent agreement with the available experimental data.

  13. Qualifying Urban Landscapes

    DEFF Research Database (Denmark)

    Juel Clemmensen, Thomas; Daugaard, Morten; Nielsen, Tom

    This paper is based on a research project aimed at contributing to the qualification of the aesthetical value of the contemporary urban landscape. We see our work as part of a tradition within the architectural profession of making explorative projects, which combines analysis of the contemporary...

  14. Qualifying Urban Landscapes

    DEFF Research Database (Denmark)

    Juel Clemmensen, Thomas; Daugaard, Morten; Nielsen, Tom

    2010-01-01

    This paper is based on a research project aimed at contributing to the qualification of the aesthetical value of the contemporary urban landscape. We see our work as part of a tradition within the architectural profession of making explorative projects, which combines analysis of the contemporary...

  15. THE IDENTIFICATION OF THE LOOKOUT POINTS WITH A ROLE IN THE TOURISM VALORISATION OF LANDSCAPE IN THE DISTRICT OF CICEU. VIEWSHED ANALYSIS

    Directory of Open Access Journals (Sweden)

    Alexandra-Camelia POTRA

    2016-11-01

    Full Text Available The increase of the visibility of a territory, in order to highlight the potential of the landscape, seen as a resource which can ensure the performance of various social-economic activities in a territory becomes achievable by arranging lookout points. Conducting the visibility analysis of such points is a common topic in the works of territorial planning, namely in terms of valorisation of landscapes and the visual impact assessment of their characteristics. The natural and the anthropic component of the District of Ciceu work together to create a valuable resource of the landscape, which are most often surprising by the presence of pitoresque valleys preserving the territorial specificities. The present study aims, in a first phase, that by the methods and tools specific to the onsite step (observation, mapping, to identify possible locations, including vestiges and historic buildings, suitable for arranging representative lookout points to present the elements of the landscape in the District of Ciceu. In order to achieve the visibility analysis, in order to highlight the assessment potential of district’s ”landscape” from the mapped lookout points, was resorted to ViewshedAnalysys method of the ArcGIS software. The use of the mapping leads to the materialization of theresults of the different cartographic representations, useful for the landscape recovery activities. The results of the study consist in generating the visibility areas of the lookout points, development of tourist routes that integrate the lookout points mapped on-site, namely to capitalize the landscape elements of the District of Ciceu.

  16. Geomorpho-Landscapes

    Science.gov (United States)

    Farabollini, Piero; Lugeri, Francesca; Amadio, Vittorio

    2014-05-01

    Landscape is the object of human perceptions, being the image of spatial organization of elements and structures: mankind lives the first approach with the environment, viewing and feeling the landscape. Many definitions of landscape have been given over time: in this case we refer to the Landscape defined as the result of interaction among physical, biotic and anthropic phenomena acting in a different spatial-temporal scale (Foreman & Godron) Following an Aristotelic approach in studying nature, we can assert that " Shape is synthesis": so it is possible to read the land features as the expression of the endogenous and exogenous processes that mould earth surfaces; moreover, Landscape is the result of the interaction of natural and cultural components, and conditions the spatial-temporal development of a region. The study of the Landscape offers results useful in order to promote sustainable development, ecotourism, enhancement of natural and cultural heritage, popularization of the scientific knowledge. In Italy, a very important GIS-based tool to represent the territory is the "Carta della Natura" ("Map of Nature", presently coordinated by the ISPRA) that aims at assessing the state of the whole Italian territory, analyzing Landscape. The methodology follows a holistic approach, taking into consideration all the components of a landscape and then integrating the information. Each individual landscape, studied at different scales, shows distinctive elements: structural, which depend on physical form and specific spatial organization; functional, which depend on relationships created between biotic and abiotic elements, and dynamic, which depend on the successive evolution of the structure. The identification of the landscape units, recognized at different scales of analysis, allows an evaluation of the state of the land, referring to the dual risk/resource which characterizes the Italian country. An interesting opportunity is to discover those areas of unusual

  17. Landscape relatedness

    DEFF Research Database (Denmark)

    Norman, Anita J; Strønen, Astrid Vik; Fuglstad, Geir-Arne

    2017-01-01

    Context Methods for detecting contemporary, fine-scale population genetic structure in continuous populations are scarce. Yet such methods are vital for ecological and conservation studies, particularly under a changing landscape. Objectives Here we present a novel, spatially explicit method that...

  18. Electromagnetic Landscape

    DEFF Research Database (Denmark)

    Cermak, Daniel; Okutsu, Ayaka; Hasse, Stina

    2015-01-01

    Electromagnetic Landscape demonstrates in direct, tangible and immediate ways effects of the disruption of the familiar. An ubiquitous technological medium, FM radio, is turned into an alien and unfamiliar one. Audience participation, the environment, radio signals and noise create a site...

  19. Disposable Landscapes

    Science.gov (United States)

    Kevin T. Smith

    2008-01-01

    Whether we are a traditionalist or on the cutting edge of landscape care, we need to take a deep breath and think about what we are trying to achieve, before we select a specific treatment or practice for tree care. We should measure that treatment or practice against what we know about the tree system. I say "system" because the recent years of Modern...

  20. Landscape as World Picture

    DEFF Research Database (Denmark)

    Wamberg, Jacob

    -consciousness, with an urban individual contemplating nature at an aesthetic distance. Apart from being structurally equivalent with the new Copernican cosmos and the colonial expansion of Western culture, the new territorial landscape image is shown to develop in close interaction with the early modern work ethic......This book presents a new and comprehensive theory concerning the manner in which landscapes in Western pictorial art may be interpreted in relation to the cultures that created them. Its point of departure is a hitherto unexplored developmental pattern that characterises landscape representation...... from Palaeolithic cave paintings through to 19th-century modernity. A structuralist comparison between this pattern and three additional fields of analysis - self-consciousness, socially-determined perception of nature, and world picture - reveals a fascinating insight into culture's macrohistorical...

  1. A data-driven analysis of energy balance closure across FLUXNET research sites: The role of landscape scale heterogeneity

    DEFF Research Database (Denmark)

    Stoy, Paul C.; Mauder, Matthias; Foken, Thomas

    2013-01-01

    on average under near-neutral atmospheric conditions. CEB,s was significantly related to mean precipitation, gross primary productivity and landscape-level enhanced vegetation index (EVI) from MODIS, and the variability in elevation, MODIS plant functional type, and MODIS EVI. A linear model including...... landscape-level variability in both EVI and elevation, mean precipitation, and an interaction term between EVI variability and precipitation had the lowest Akaike's information criterion value. CEB,s in landscapes with uniform plant functional type approached 0.9 and CEB,s in landscapes with uniform EVI...

  2. Drainage Analysis of the South American Landscape and its Tectonic Implications

    Science.gov (United States)

    Rodríguez Tribaldos, Verónica; White, Nicholas J.; Roberts, Gareth G.

    2016-04-01

    The majority of studies aimed at investigating topographic growth and landscape evolution have limited spatial coverage. Frequently, spot measurements of uplift and denudation are only available, which hampers spatial resolution of the growth of regional topographic features. This limitation can be overcome by quantitatively analysing substantial, continent-wide, drainage networks. The shapes of long wavelength longitudinal river profiles appear to be mainly controlled by regional uplift and moderated by erosional processes, both of which can vary as a function of space and time. By parametrizing erosional histories, it is feasible to develop inverse models that permit spatial and temporal patterns of regional uplift to be reliably retrieved. Here, a drainage inventory for South America consisting of 1827 rivers has been inverted. River profiles were extracted from the SRTM topographic dataset and modelled using a simplified version of the stream-power law, in which erosional processes are described using a linear advective formulation. The inverse problem is then solved by seeking smooth uplift rate histories that minimize the misfit between observed and calculated river profiles using a linearized, damped, non-negative, least squares algorithm. Calibration of erosional processes is achieved by inverting the complete drainage inventory and seeking a calculated uplift history that best honours independent geological observations from the Borborema Province of northeast Brazil. This province experienced regional Cenozoic uplift. Calculated uplift rate histories for South America suggest that the bulk of its topography developed during Cenozoic times. The model suggests, for instance, that the Andean mountain chain mostly arose in late Eocene-Oligocene (i.e. 40-28 Ma) times with an increase in elevation during Miocene times (i.e. the last 20 Ma). Uplift of the Central Andean Altiplano from an elevation of ~ 1 km to its present-day height of ~ 4 km occurred within the

  3. Site-specific climate analysis elucidates revegetation challenges for post-mining landscapes in eastern Australia

    Directory of Open Access Journals (Sweden)

    P. Audet

    2013-10-01

    Full Text Available In eastern Australia, the availability of water is critical for the successful rehabilitation of post-mining landscapes and climatic characteristics of this diverse geographical region are closely defined by factors such as erratic rainfall and periods of drought and flooding. Despite this, specific metrics of climate patterning are seldom incorporated into the initial design of current post-mining land rehabilitation strategies. Our study proposes that a few common rainfall parameters can be combined and rated using arbitrary rainfall thresholds to characterise bioregional climate sensitivity relevant to the rehabilitation these landscapes. This approach included assessments of annual rainfall depth, average recurrence interval of prolonged low intensity rainfall, average recurrence intervals of short or prolonged high intensity events, median period without rain (or water-deficit and standard deviation for this period in order to address climatic factors such as total water availability, seasonality and intensity – which were selected as potential proxies of both short- and long-term biological sensitivity to climate within the context of post-disturbance ecological development and recovery. Following our survey of available climate data, we derived site "climate sensitivity" indexes and compared the performance of 9 ongoing mine sites: Weipa, Mt. Isa and Cloncurry, Eromanga, Kidston, the Bowen Basin (Curragh, Tarong, North Stradbroke Island, and the Newnes Plateau. The sites were then ranked from most-to-least sensitive and compared with natural bioregional patterns of vegetation density using mean NDVI. It was determined that regular rainfall and relatively short periods of water-deficit were key characteristics of sites having less sensitivity to climate – as found among the relatively more temperate inland mining locations. Whereas, high rainfall variability, frequently occurring high intensity events, and (or prolonged seasonal

  4. Application of principal component analysis to ecodiversity assessment of postglacial landscape (on the example of Debnica Kaszubska commune, Middle Pomerania)

    Science.gov (United States)

    Wojciechowski, Adam

    2017-04-01

    In order to assess ecodiversity understood as a comprehensive natural landscape factor (Jedicke 2001), it is necessary to apply research methods which recognize the environment in a holistic way. Principal component analysis may be considered as one of such methods as it allows to distinguish the main factors determining landscape diversity on the one hand, and enables to discover regularities shaping the relationships between various elements of the environment under study on the other hand. The procedure adopted to assess ecodiversity with the use of principal component analysis involves: a) determining and selecting appropriate factors of the assessed environment qualities (hypsometric, geological, hydrographic, plant, and others); b) calculating the absolute value of individual qualities for the basic areas under analysis (e.g. river length, forest area, altitude differences, etc.); c) principal components analysis and obtaining factor maps (maps of selected components); d) generating a resultant, detailed map and isolating several classes of ecodiversity. An assessment of ecodiversity with the use of principal component analysis was conducted in the test area of 299,67 km2 in Debnica Kaszubska commune. The whole commune is situated in the Weichselian glaciation area of high hypsometric and morphological diversity as well as high geo- and biodiversity. The analysis was based on topographical maps of the commune area in scale 1:25000 and maps of forest habitats. Consequently, nine factors reflecting basic environment elements were calculated: maximum height (m), minimum height (m), average height (m), the length of watercourses (km), the area of water reservoirs (m2), total forest area (ha), coniferous forests habitats area (ha), deciduous forest habitats area (ha), alder habitats area (ha). The values for individual factors were analysed for 358 grid cells of 1 km2. Based on the principal components analysis, four major factors affecting commune ecodiversity

  5. European landscape character areas : typologies, cartography and indicators for the assessment of sustainable landscapes

    NARCIS (Netherlands)

    Wascher, D.M.

    2005-01-01

    Landscape Character Assessment (LCA) is designed to describe landscape character. It can be applied at a range of scales, from the national, though to the regional and local. It may also integrate landscape character analysis with biodiversity assessments, the analysis of historical character, air,

  6. From curve fitting to machine learning an illustrative guide to scientific data analysis and computational intelligence

    CERN Document Server

    Zielesny, Achim

    2016-01-01

    This successful book provides in its second edition an interactive and illustrative guide from two-dimensional curve fitting to multidimensional clustering and machine learning with neural networks or support vector machines. Along the way topics like mathematical optimization or evolutionary algorithms are touched. All concepts and ideas are outlined in a clear cut manner with graphically depicted plausibility arguments and a little elementary mathematics. The major topics are extensively outlined with exploratory examples and applications. The primary goal is to be as illustrative as possible without hiding problems and pitfalls but to address them. The character of an illustrative cookbook is complemented with specific sections that address more fundamental questions like the relation between machine learning and human intelligence. All topics are completely demonstrated with the computing platform Mathematica and the Computational Intelligence Packages (CIP), a high-level function library developed with M...

  7. Trends in landscape research and landscape planning : implications for PhD students

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Fry, G.; Antrop, M.

    2005-01-01

    This chapter introduces the contents of the book through an analysis of current trends in landscape research and landscape planning and a discussion of the consequences of these trends for PhD students.

  8. The New Minimal Supersymmetric GUT: Spectra, RG analysis and fermion fits

    Science.gov (United States)

    Aulakh, Charanjit S.; Garg, Sumit K.

    2012-04-01

    The supersymmetric SO(10) GUT based on the 210⊕10⊕120⊕126⊕126¯ Higgs system provides a minimal framework for the emergence of the R-parity exact MSSM at low energies and a viable supersymmetric seesaw explanation for the observed neutrino masses and mixing angles. We present formulae for MSSM decomposition of the superpotential invariants, tree level light charged fermion effective Yukawa couplings, Weinberg neutrino mass generation operator, and the d=5, ΔB=ΔL≠0 effective superpotential in terms of GUT parameters. We use them to determine fits of the 18 available fermion mass-mixing data in terms of the superpotential parameters of the NMSGUT and SUGRY (NUHM) type soft supersymmetry breaking parameters ({m,m,A,MH,H¯2}) specified at the MSSM one-loop unification scale MX0=10 GeV. Our fits are compatible with electroweak symmetry breaking and Unification constraints and yield right-handed neutrino masses in the leptogenesis relevant range: 10-10 GeV. Matching the SM data requires lowering the strange and down quark Yukawas in the MSSM via large tanβ driven threshold corrections and characteristic soft Susy breaking spectra. The standard model Higgs mass emerges less than 130 GeV. The Susy spectra have light pure Bino LSP, heavy exotic Higgs(inos) and large μ, A, M parameters ˜100 TeV. Typically third generation sfermions are much heavier than the first two generations. The smuon is often the lightest charged sfermion thus offering a Bino-CDM co-annihilation channel. The parameter sets obtained are used to calculate B violation rates which are found to be generically much faster (˜10 yr) than the current experimental limits. Improvements which may allow acceptable B violation rates are identified.

  9. Downward dog becomes fit body, inc.: A content analysis of 40 years of female cover images of Yoga Journal.

    Science.gov (United States)

    Webb, Jennifer B; Vinoski, Erin R; Warren-Findlow, Jan; Burrell, Marlene I; Putz, Davina Y

    2017-09-01

    The present analysis investigated temporal trends in physical appearance attributes and attire worn by female cover models of Yoga Journal magazine between the years 1975-2015. Covers featuring a single female model (N=168) were coded for: pose activity, amount of body visibility, perceived body size, body shape, breast size, skin exposure, and revealing or form-fitting attire. When collapsed across all decades, the majority of cover models was actively posed with high body visibility, rated as at most low normal weight, possessed either a "thin/lean" or "skinny/boney" body shape, and were "flat-chested" or "small-breasted". Greater body visibility, pose activity, thinness/leanness, skin exposure, and form-fitting attire were featured on more recent years' covers. Findings suggest that the female "yoga body" conforms to the contemporary thin- and-toned media fitness ideal, particularly recently, which may promote objectified body competence, an unhealthy drive for leanness, and dissuade higher weight women from considering yoga practice. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Model-based analysis of multi-shell diffusion MR data for tractography: How to get over fitting problems

    Science.gov (United States)

    Jbabdi, Saad; Sotiropoulos, Stamatios N; Savio, Alexander M; Graña, Manuel; Behrens, Timothy EJ

    2012-01-01

    In this article, we highlight an issue that arises when using multiple b-values in a model-based analysis of diffusion MR data for tractography. The non-mono-exponential decay, commonly observed in experimental data, is shown to induce over-fitting in the distribution of fibre orientations when not considered in the model. Extra fibre orientations perpendicular to the main orientation arise to compensate for the slower apparent signal decay at higher b-values. We propose a simple extension to the ball and stick model based on a continuous Gamma distribution of diffusivities, which significantly improves the fitting and reduces the over-fitting. Using in-vivo experimental data, we show that this model outperforms a simpler, noise floor model, especially at the interfaces between brain tissues, suggesting that partial volume effects are a major cause of the observed non-mono-exponential decay. This model may be helpful for future data acquisition strategies that may attempt to combine multiple shells to improve estimates of fibre orientations in white matter and near the cortex. PMID:22334356

  11. Fitness Club

    CERN Multimedia

    Fitness Club

    2012-01-01

    Open to All: http://cern.ch/club-fitness  fitness.club@cern.ch Boxing Your supervisor makes your life too tough ! You really need to release the pressure you've been building up ! Come and join the fit-boxers. We train three times a week in Bd 216, classes for beginners and advanced available. Visit our website cern.ch/Boxing General Fitness Escape from your desk with our general fitness classes, to strengthen your heart, muscles and bones, improve you stamina, balance and flexibility, achieve new goals, be more productive and experience a sense of well-being, every Monday, Wednesday and Friday lunchtime, Tuesday mornings before work and Thursday evenings after work – join us for one of our monthly fitness workshops. Nordic Walking Enjoy the great outdoors; Nordic Walking is a great way to get your whole body moving and to significantly improve the condition of your muscles, heart and lungs. It will boost your energy levels no end. Pilates A body-conditioning technique de...

  12. The Use of Statistical Process Control-Charts for Person-Fit Analysis on Computerized Adaptive Testing. LSAC Research Report Series.

    Science.gov (United States)

    Meijer, Rob R.; van Krimpen-Stoop, Edith M. L. A.

    In this study a cumulative-sum (CUSUM) procedure from the theory of Statistical Process Control was modified and applied in the context of person-fit analysis in a computerized adaptive testing (CAT) environment. Six person-fit statistics were proposed using the CUSUM procedure, and three of them could be used to investigate the CAT in online test…

  13. ANALYSIS OF THE INFLUENCE OF LANDFORMS ON LANDSCAPE MOLDING AND LAND MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Tomasz Oberski

    2014-10-01

    Full Text Available Landscaping has a major impact on the natural phenomena that occur on the surface of the Earth. Directive 2000/60/EC of the European Parliament and of the Council of Europe (23/10/2000 prescribes an obligation of sustainable management of water resources, including by protecting them against deterioration of water, aquatic and terrestrial ecosystems and wetlands dependent on water. Origins of wetlands and natural water reservoirs associated with the structure and the type of soil, topography, the surface flow of water in the hydrological cycle and the groundwater that emanates as a stream water under sloping impermeable layer. The Szwedow-Birghman equation describes the function of gravity relating flow of terrain which is density-plastic soil on slope surface. The movement of soil on sloping angle stops after reaching the final state. The final state will profile H = H0 that shows the terrain in stability condition. Over time, the shape of any profile will become regular independent of its original condition, and in its lower part forms a zone of accumulation, which under certain conditions, hydrological and soil will be a natural barrier for surface and underground water. The aim of this study was to develop methods to assess the stability of the terrain using modern methods of photogrammetry and geospatial and gain areas at risk of flooding acquisition and pollution associated with the flow of surface water and groundwater.

  14. Mesoscopic model and free energy landscape for protein-DNA binding sites: analysis of cyanobacterial promoters.

    Directory of Open Access Journals (Sweden)

    Rafael Tapia-Rojo

    2014-10-01

    Full Text Available The identification of protein binding sites in promoter sequences is a key problem to understand and control regulation in biochemistry and biotechnological processes. We use a computational method to analyze promoters from a given genome. Our approach is based on a physical model at the mesoscopic level of protein-DNA interaction based on the influence of DNA local conformation on the dynamics of a general particle along the chain. Following the proposed model, the joined dynamics of the protein particle and the DNA portion of interest, only characterized by its base pair sequence, is simulated. The simulation output is analyzed by generating and analyzing the Free Energy Landscape of the system. In order to prove the capacity of prediction of our computational method we have analyzed nine promoters of Anabaena PCC 7120. We are able to identify the transcription starting site of each of the promoters as the most populated macrostate in the dynamics. The developed procedure allows also to characterize promoter macrostates in terms of thermo-statistical magnitudes (free energy and entropy, with valuable biological implications. Our results agree with independent previous experimental results. Thus, our methods appear as a powerful complementary tool for identifying protein binding sites in promoter sequences.

  15. Scaling in landscape erosion: Renormalization group analysis of a model with infinitely many couplings

    Science.gov (United States)

    Antonov, N. V.; Kakin, P. I.

    2017-02-01

    Applying the standard field theory renormalization group to the model of landscape erosion introduced by Pastor-Satorras and Rothman yields unexpected results: the model is multiplicatively renormalizable only if it involves infinitely many coupling constants (i.e., the corresponding renormalization group equations involve infinitely many β-functions). We show that the one-loop counterterm can nevertheless be expressed in terms of a known function V (h) in the original stochastic equation and its derivatives with respect to the height field h. Its Taylor expansion yields the full infinite set of the one-loop renormalization constants, β-functions, and anomalous dimensions. Instead of a set of fixed points, there arises a two-dimensional surface of fixed points that quite probably contains infrared attractive regions. If that is the case, then the model exhibits scaling behavior in the infrared range. The corresponding critical exponents turn out to be nonuniversal because they depend on the coordinates of the fixed point on the surface, but they satisfy certain universal exact relations.

  16. Retrospective analysis of anthropometric and fitness characteristics associated with long-term career progression in Rugby League.

    Science.gov (United States)

    Till, Kevin; Cobley, Steve; O'Hara, John; Morley, David; Chapman, Chris; Cooke, Carlton

    2015-05-01

    The current study retrospectively investigated the differences in anthropometric and fitness characteristics of junior rugby league players selected onto a talent identification and development (TID) programme between long-term career progression levels (i.e., amateur, academy, professional). Retrospective design. Former junior rugby league players (N=580) selected to a TID programme were grouped according to their career progression level. Anthropometric (height, sitting height, body mass and sum of four skinfolds), maturational and fitness (power, speed, change of direction speed and estimated V̇O2max) assessments were conducted at 13-15 years. Multivariate analysis of covariance (MANCOVA) analyzed differences between career progression levels controlling for chronological age. 57.1% and 12.1% of players selected to the TID programme progressed to academy and professional levels in rugby league, respectively. Sum of four skinfolds (η(2)=0.03), vertical jump (η(2)=0.02), 10 m (η(2)=0.02), 20 m (η(2)=0.02), 30 m (η(2)=0.02), and 60 m (η(2)=0.03) speed, agility 505 left (η(2)=0.06), agility 505 right (η(2)=0.05) and estimated V̇O2max (η(2)=0.03) were superior within junior players who progressed to professional compared to amateur levels. No significant differences were identified between future academy and professional players for any measure. Findings suggest that lower sum of four skinfolds and advanced fitness characteristics within junior (13-15 years) rugby league players may partially contribute to long-term career progression. Therefore, TID programmes within rugby league should aim to assess and develop body composition and fitness characteristics, especially change of direction speed. However, TID programmes should also consider technical, tactical and psycho-social characteristics of junior rugby league players that may be important for long-term career progression. Copyright © 2014 Sports Medicine Australia. Published by Elsevier Ltd. All

  17. Competitive priorities for service operations strategy: an analysis of the perceived-value criteria of a fitness center

    Directory of Open Access Journals (Sweden)

    Luciano Costa Santos

    2012-01-01

    Full Text Available The setting of priorities among the various performance objectives is one of the main activities in the formulation of manufacturing strategy. Recognizing the importance of this activity and using the nomenclature of “perceived-value criteria”, this paper reports an analysis of competitive priorities of a fitness center, which was an essential part of a broader process aimed at the formulation of operations strategy for the company. After a brief literature review, the article proposes a model for the analysis of perceived-value criteria in service operations that, among other tools, makes use of importance-performance matrix and trade-off analysis. To validate its applicability, the proposed model was field-tested in an action research approach, in which one of the authors of this paper played the role of external facilitator of the process of organizational intervention. The application of the model allowed identifying the processes and the perceived-value criteria (PVC's that should be prioritized by the company, using for this, two bases of comparison: the direct competitors of its influence area and the benchmark fitness centers (best practices. As a result, the firm's managers were able to better decide about the different strategic alternatives to improve its operations.

  18. Evaluation principles in Landscape Projects

    Directory of Open Access Journals (Sweden)

    Saverio Miccoli

    2013-08-01

    Full Text Available Landscape is a crucial component of the world heritage. Landscape projects play a vital role in the development of sustainable scenarios. The assessment of a project plays a dual role: it is a procedure to pass judgements on both “values” and “choices”. From a strictly economic perspective, the community’s appreciation of Landscape Projects may be ascertained through its “total economic value”. The value of a Landscape Project may be ascertained also through a multidimensional approach, based on the analysis of different project attributes whose outcome is calculated in non-monetary terms. This paper illustrates the cultural foundations and theoretical-methodological principles to assess Landscape Projects.

  19. Spatial Analysis of Cultural Heritage Landscapes in Rural China: Land Use Change and Its Risks for Conservation

    Science.gov (United States)

    Yu, Huirong; Verburg, Peter H.; Liu, Liming; Eitelberg, David A.

    2016-06-01

    Cultural heritage landscapes are consistently perceived as landscapes of high value. However, these landscapes are very vulnerable to change. In China, rapid land use change, especially urbanization, has become one of the main challenges for the conservation of cultural heritage landscapes in rural areas. This paper focuses on the designated cultural villages in rural China by systematically analyzing the spatial distribution of the designated cultural landscape across the country and assessing the threats these traditional landscapes are facing under current and future urbanization and other land use pressures. Current designated cultural heritage landscapes in China are predominantly located in the rural and peri-urban regions of Central and South China and less frequently found in other regions. Especially in these regions risks to land use change are large. These risks are assessed based on observed recent land use change and land use model simulations for scenarios up to 2050. The risk assessment reveals that especially in Southeast China along the sea coast and near the cities along the Yangtze River, high pressures are expected on cultural heritage landscapes due to urbanization. At the same time, in Southwest China, especially in Yunnan and Guizhou provinces, high pressures due to other land use changes are expected, including land abandonment. This assessment gives direction and guidance toward the selection of the most threatened cultural villages for detailed investigation and additional protection measures.

  20. Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates.

    Science.gov (United States)

    Yu, Hao; Gupta, Amar Nath; Liu, Xia; Neupane, Krishna; Brigley, Angela M; Sosova, Iveta; Woodside, Michael T

    2012-09-04

    Protein folding is described conceptually in terms of diffusion over a configurational free-energy landscape, typically reduced to a one-dimensional profile along a reaction coordinate. In principle, kinetic properties can be predicted directly from the landscape profile using Kramers theory for diffusive barrier crossing, including the folding rates and the transition time for crossing the barrier. Landscape theory has been widely applied to interpret the time scales for protein conformational dynamics, but protein folding rates and transition times have not been calculated directly from experimentally measured free-energy profiles. We characterized the energy landscape for native folding of the prion protein using force spectroscopy, measuring the change in extension of a single protein molecule at high resolution as it unfolded/refolded under tension. Key parameters describing the landscape profile were first recovered from the distributions of unfolding and refolding forces, allowing the diffusion constant for barrier crossing and the transition path time across the barrier to be calculated. The full landscape profile was then reconstructed from force-extension curves, revealing a double-well potential with an extended, partially unfolded transition state. The barrier height and position were consistent with the previous results. Finally, Kramers theory was used to predict the folding rates from the landscape profile, recovering the values observed experimentally both under tension and at zero force in ensemble experiments. These results demonstrate how advances in single-molecule theory and experiment are harnessing the power of landscape formalisms to describe quantitatively the mechanics of folding.

  1. Spatial Analysis of Cultural Heritage Landscapes in Rural China: Land Use Change and Its Risks for Conservation.

    Science.gov (United States)

    Yu, Huirong; Verburg, Peter H; Liu, Liming; Eitelberg, David A

    2016-06-01

    Cultural heritage landscapes are consistently perceived as landscapes of high value. However, these landscapes are very vulnerable to change. In China, rapid land use change, especially urbanization, has become one of the main challenges for the conservation of cultural heritage landscapes in rural areas. This paper focuses on the designated cultural villages in rural China by systematically analyzing the spatial distribution of the designated cultural landscape across the country and assessing the threats these traditional landscapes are facing under current and future urbanization and other land use pressures. Current designated cultural heritage landscapes in China are predominantly located in the rural and peri-urban regions of Central and South China and less frequently found in other regions. Especially in these regions risks to land use change are large. These risks are assessed based on observed recent land use change and land use model simulations for scenarios up to 2050. The risk assessment reveals that especially in Southeast China along the sea coast and near the cities along the Yangtze River, high pressures are expected on cultural heritage landscapes due to urbanization. At the same time, in Southwest China, especially in Yunnan and Guizhou provinces, high pressures due to other land use changes are expected, including land abandonment. This assessment gives direction and guidance toward the selection of the most threatened cultural villages for detailed investigation and additional protection measures.

  2. Integrated analysis of landscape management scenarios using state and transition models in the upper Grande Ronde River subbasin, Oregon, USA.

    Science.gov (United States)

    Miles A. Hemstrom; James Merzenich; Allison Reger; Barbara. Wales

    2007-01-01

    We modeled the integrated effects of natural disturbances and management activities for three disturbance scenarios on a 178 000-ha landscape in the upper Grande Ronde subbasin of northeast Oregon. The landscape included three forest environments (warm-dry, cool-moist, and cold) as well as a mixture of publicly and privately owned lands. Our models were state and...

  3. Forest Loss in Protected Areas and Intact Forest Landscapes: A Global Analysis.

    Directory of Open Access Journals (Sweden)

    Matias Heino

    Full Text Available In spite of the high importance of forests, global forest loss has remained alarmingly high during the last decades. Forest loss at a global scale has been unveiled with increasingly finer spatial resolution, but the forest extent and loss in protected areas (PAs and in large intact forest landscapes (IFLs have not so far been systematically assessed. Moreover, the impact of protection on preserving the IFLs is not well understood. In this study we conducted a consistent assessment of the global forest loss in PAs and IFLs over the period 2000-2012. We used recently published global remote sensing based spatial forest cover change data, being a uniform and consistent dataset over space and time, together with global datasets on PAs' and IFLs' locations. Our analyses revealed that on a global scale 3% of the protected forest, 2.5% of the intact forest, and 1.5% of the protected intact forest were lost during the study period. These forest loss rates are relatively high compared to global total forest loss of 5% for the same time period. The variation in forest losses and in protection effect was large among geographical regions and countries. In some regions the loss in protected forests exceeded 5% (e.g. in Australia and Oceania, and North America and the relative forest loss was higher inside protected areas than outside those areas (e.g. in Mongolia and parts of Africa, Central Asia, and Europe. At the same time, protection was found to prevent forest loss in several countries (e.g. in South America and Southeast Asia. Globally, high area-weighted forest loss rates of protected and intact forests were associated with high gross domestic product and in the case of protected forests also with high proportions of agricultural land. Our findings reinforce the need for improved understanding of the reasons for the high forest losses in PAs and IFLs and strategies to prevent further losses.

  4. Forest Loss in Protected Areas and Intact Forest Landscapes: A Global Analysis.

    Science.gov (United States)

    Heino, Matias; Kummu, Matti; Makkonen, Marika; Mulligan, Mark; Verburg, Peter H; Jalava, Mika; Räsänen, Timo A

    2015-01-01

    In spite of the high importance of forests, global forest loss has remained alarmingly high during the last decades. Forest loss at a global scale has been unveiled with increasingly finer spatial resolution, but the forest extent and loss in protected areas (PAs) and in large intact forest landscapes (IFLs) have not so far been systematically assessed. Moreover, the impact of protection on preserving the IFLs is not well understood. In this study we conducted a consistent assessment of the global forest loss in PAs and IFLs over the period 2000-2012. We used recently published global remote sensing based spatial forest cover change data, being a uniform and consistent dataset over space and time, together with global datasets on PAs' and IFLs' locations. Our analyses revealed that on a global scale 3% of the protected forest, 2.5% of the intact forest, and 1.5% of the protected intact forest were lost during the study period. These forest loss rates are relatively high compared to global total forest loss of 5% for the same time period. The variation in forest losses and in protection effect was large among geographical regions and countries. In some regions the loss in protected forests exceeded 5% (e.g. in Australia and Oceania, and North America) and the relative forest loss was higher inside protected areas than outside those areas (e.g. in Mongolia and parts of Africa, Central Asia, and Europe). At the same time, protection was found to prevent forest loss in several countries (e.g. in South America and Southeast Asia). Globally, high area-weighted forest loss rates of protected and intact forests were associated with high gross domestic product and in the case of protected forests also with high proportions of agricultural land. Our findings reinforce the need for improved understanding of the reasons for the high forest losses in PAs and IFLs and strategies to prevent further losses.

  5. Spatio-temporal analysis on land transformation in a forested tropical landscape in Jambi Province, Sumatra

    Science.gov (United States)

    Melati, Dian N.; Nengah Surati Jaya, I.; Pérez-Cruzado, César; Zuhdi, Muhammad; Fehrmann, Lutz; Magdon, Paul; Kleinn, Christoph

    2015-04-01

    Land use/land cover (LULC) in forested tropical landscapes is very dynamically developing. In particular, the pace of forest conversion in the tropics is a global concern as it directly impacts the global carbon cycle and biodiversity conservation. Expansion of agriculture is known to be among the major drivers of forest loss especially in the tropics. This is also the case in Jambi Province, Sumatra, Indonesia where it is the mainly expansion of tree crops that triggers deforestation: oil palm and rubber trees. Another transformation system in Jambi is the one from natural forest into jungle rubber, which is an agroforestry system where a certain density of forest trees accompanies the rubber tree crop, also for production of wood and non-wood forest products. The spatial distribution and the dynamics of these transformation systems and of the remaining forests are essential information for example for further research on ecosystem services and on the drivers of land transformation. In order to study land transformation, maps from the years 1990, 2000, 2011, and 2013 were utilized, derived from visual interpretation of Landsat images. From these maps, we analyze the land use/land cover change (LULCC) in the study region. It is found that secondary dryland forest (on mineral soils) and secondary swamp forest have been transformed largely into (temporary) shrub land, plantation forests, mixed dryland agriculture, bare lands and estate crops where the latter include the oil palm and rubber plantations. In addition, we present some analyses of the spatial pattern of land transformation to better understand the process of LULC fragmentation within the studied periods. Furthermore, the driving forces are analyzed.

  6. Improving the interpretability of climate landscape metrics: An ecological risk analysis of Japan's Marine Protected Areas.

    Science.gov (United States)

    García Molinos, Jorge; Takao, Shintaro; Kumagai, Naoki H; Poloczanska, Elvira S; Burrows, Michael T; Fujii, Masahiko; Yamano, Hiroya

    2017-02-17

    Conservation efforts strive to protect significant swaths of terrestrial, freshwater and marine ecosystems from a range of threats. As climate change becomes an increasing concern, these efforts must take into account how resilient-protected spaces will be in the face of future drivers of change such as warming temperatures. Climate landscape metrics, which signal the spatial magnitude and direction of climate change, support a convenient initial assessment of potential threats to and opportunities within ecosystems to inform conservation and policy efforts where biological data are not available. However, inference of risk from purely physical climatic changes is difficult unless set in a meaningful ecological context. Here, we aim to establish this context using historical climatic variability, as a proxy for local adaptation by resident biota, to identify areas where current local climate conditions will remain extant and future regional climate analogues will emerge. This information is then related to the processes governing species' climate-driven range edge dynamics, differentiating changes in local climate conditions as promoters of species range contractions from those in neighbouring locations facilitating range expansions. We applied this approach to assess the future climatic stability and connectivity of Japanese waters and its network of marine protected areas (MPAs). We find 88% of Japanese waters transitioning to climates outside their historical variability bounds by 2035, resulting in large reductions in the amount of available climatic space potentially promoting widespread range contractions and expansions. Areas of high connectivity, where shifting climates converge, are present along sections of the coast facilitated by the strong latitudinal gradient of the Japanese archipelago and its ocean current system. While these areas overlap significantly with areas currently under significant anthropogenic pressures, they also include much of the MPA

  7. Scaling in erosion of landscapes: renormalization group analysis of a model with turbulent mixing

    Science.gov (United States)

    Antonov, N. V.; Kakin, P. I.

    2017-02-01

    The model of landscape erosion, introduced in (1998 Phys. Rev. Lett. 80 4349, 1998 J. Stat. Phys. 93 477) and modified in (2016 Theor. Math. Phys. in press (arXiv:1602.00432)), is advected by anisotropic velocity field. The field is Gaussian with vanishing correlation time and the pair correlation function of the form \\propto δ ≤ft(t-{{t}\\prime}\\right)/k\\botd-1+ξ , where {{k}\\bot}=|{{\\mathbf{k}}\\bot}| and {{\\mathbf{k}}\\bot} is the component of the wave vector, perpendicular to a certain preferred direction—the d-dimensional generalization of the ensemble introduced by Avellaneda and Majda (1990 Commun. Math. Phys. 131 381). Analogous to the case without advection, the model is multiplicatively renormalizable and has infinitely many coupling constants. The one-loop counterterm is derived in a closed form in terms of the certain function V(h), entering the original stochastic equation, and its derivatives with respect to the height field h≤ft(t,\\mathbf{x}\\right) . The full infinite set of the one-loop renormalization constants, β-functions and anomalous dimensions is obtained from the Taylor expansion of the counter-term. Instead of a two-dimensional surface of fixed points there are two such surfaces; they are likely to contain infrared attractive region(s). If that is the case, the model exhibits scaling behaviour in the infrared range. The corresponding critical exponents are non-universal because they depend on the coordinates of the fixed points on the surface; they also satisfy certain universal exact relation.

  8. The histone H3 N-terminal tail: a computational analysis of the free energy landscape and kinetics.

    Science.gov (United States)

    Zheng, Yuqing; Cui, Qiang

    2015-05-28

    Histone tails are the short peptide protrusions outside of the nucleosome core particle and they play a critical role in regulating chromatin dynamics and gene activity. A histone H3 N-terminal tail, like other histone tails, can be covalently modified on different residues to activate or repress gene expression. Previous studies have indicated that, despite its intrinsically disordered nature, the histone H3 N-terminal tail has regions of notable secondary structural propensities. To further understand the structure-dynamics-function relationship in this system, we have carried out 75.6 μs long implicit solvent simulations and 29.3 μs long explicit solvent simulations. The extensive samplings allow us to better characterize not only the underlying free energy landscape but also kinetic properties through Markov state models (MSM). Dihedral principal component analysis (dPCA) and locally scaled diffusion map (LSDMap) analysis yield consistent results that indicate an overall flat free energy surface with several shallow basins that correspond to conformations with a high α-helical propensity in two regions of the peptide. Kinetic information extracted from Markov state models reveals rapid transitions between different metastable states with mean first passage times spanning from several hundreds of nanoseconds to hundreds of microseconds. These findings shed light on how the dynamical nature of the histone H3 N-terminal tail is related to its function. The complementary nature of dPCA, LSDMap and MSM for the analysis of biomolecules is also discussed.

  9. Seismogram Analysis and Fitting of Three Earthquakes, West Papua, Recorded at Stations ENH and KMI, China

    Institute of Scientific and Technical Information of China (English)

    Bagus Jaya Santosa

    2008-01-01

    The S wave velocity structure of the earth below Eastern Southeast Asia has been investigated by analyzing the seismogram from surface wave to multiple depth waves in the time domain and three Cartesian components simultaneously. The wave passes across the front area of subduction zone between the Philippine plate and the Asian plate. The main data are waveform comparisons, instead of the arrival times. The synthetic seismogram is calculated using the GEMINI method. The synthetic seismogram constructed by PREMAN global earth model deviates greatly from the measured one. To solve this problem, corrections are needed for the β speed structure. Corrections cover the gradient change of βh>, which turns from negative to positive in upper mantle layers as in the PREMAN, change of earth crust depth and change of zero order coefficients of β velocity function in all earth mantle layers. So, the fitting is obtained, as well as the arrival time or the waveform of Love and Rayleigh surface waves, the S wave and the repetitive depth waves ScS2> and ScS3. This result reveals that the Southeast Asia, being stretched due to tectonic release, has a mantle in some parts with negative anomaly of S wave velocity and vertical anisotropy in all earth mantle layers.

  10. Goodness-of-fit analysis of the Cosmicflows-2 database of velocities

    CERN Document Server

    Hoffman, Yehuda; Courtois, Helene M; Tully, R Brent

    2016-01-01

    The goodness-of-fit (GoF) of the Cosmicflows-2 (CF2) database of peculiar velocities with the LCDM standard model of cosmology is presented. Standard application of the Chi^2 statistics of the full database, of its 4,838 data points, is hampered by the the small scale nonlinear dynamics which is not accounted for by the (linear regime) velocity power spectrum. The bulk velocity constitutes a highly compressed representation of the data which filters out the small scales non-linear modes. Hence the statistics of the bulk flow provides an efficient tool for assessing the GoF of the data given a model. The particular approach introduced here is to use the (spherical top-hat window) bulk velocity extracted from the Wiener filter reconstruction of the 3D velocity field as a linear low pass filtered highly compressed representation of the CF2 data. An ensemble 2250 random linear realizations of the WMAP/LCDM model has been used to calculate the bulk velocity auto-covariance matrix. We find that the CF2 data is cons...

  11. Goodness-of-fit analysis of the Cosmicflows-2 data base of velocities

    Science.gov (United States)

    Hoffman, Yehuda; Nusser, Adi; Courtois, Hélène M.; Tully, R. Brent

    2016-10-01

    The goodness-of-fit (GoF) of the Cosmicflows-2 (CF2) data base of peculiar velocities with the Λ cold dark matter (ΛCDM) standard model of cosmology is presented. Standard application of the χ2 statistics of the full data base, of its 4838 data points, is hampered by the small-scale non-linear dynamics which is not accounted for by the (linear regime) velocity power spectrum. The bulk velocity constitutes a highly compressed representation of the data which filters out the small-scales non-linear modes. Hence the statistics of the bulk flow provides an efficient tool for assessing the GoF of the data given a model. The particular approach introduced here is to use the (spherical top-hat window) bulk velocity extracted from the Wiener filter reconstruction of the 3D velocity field as a linear low-pass filtered highly compressed representation of the CF2 data. An ensemble 2250 random linear realizations of the Wilkinson Microwave Anisotropy Probe (WMAP)/ΛCDM model has been used to calculate the bulk velocity autocovariance matrix. We find that the CF2 data is consistent with the WMAP/ΛCDM model to better than the 2σ confidence limits. This provides a further validation that the CF2 data base is consistent with the standard model of cosmology.

  12. Stress analysis for the candidate of lower end fitting of advanced LWR fuel using FEM

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S. S.; Moon, Y. C. [Korea University of Technology and Education, Chonan (Korea, Republic of); Kim, H. K. [Korea Nuclear Fuel Company, Taejon (Korea, Republic of)

    2002-10-01

    The geometric modeling has been conducted for the candidate of advanced LWR fuel using the three-dimensional solid modeler. Then the three-dimensional stress analysis using MSC/NASTRAN has been performed. The evaluation for the mechanical integrity of the candidate has been performed based on the stress distribution obtained from the finite elements analysis.

  13. One Size Fits All: Evaluation of the Transferability of a New "Learning" Histologic Image Analysis Application.

    Science.gov (United States)

    Arlt, Janine; Homeyer, André; Sänger, Constanze; Dahmen, Uta; Dirsch, Olaf

    2016-01-01

    Quantitative analysis of histologic slides is of importance for pathology and also to address surgical questions. Recently, a novel application was developed for the automated quantification of whole-slide images. The aim of this study was to test and validate the underlying image analysis algorithm with respect to user friendliness, accuracy, and transferability to different histologic scenarios. The algorithm splits the images into tiles of a predetermined size and identifies the tissue class of each tile. In the training procedure, the user specifies example tiles of the different tissue classes. In the subsequent analysis procedure, the algorithm classifies each tile into the previously specified classes. User friendliness was evaluated by recording training time and testing reproducibility of the training procedure of users with different background. Accuracy was determined with respect to single and batch analysis. Transferability was demonstrated by analyzing tissue of different organs (rat liver, kidney, small bowel, and spleen) and with different stainings (glutamine synthetase and hematoxylin-eosin). Users of different educational background could apply the program efficiently after a short introduction. When analyzing images with similar properties, accuracy of >90% was reached in single images as well as in batch mode. We demonstrated that the novel application is user friendly and very accurate. With the "training" procedure the application can be adapted to novel image characteristics simply by giving examples of relevant tissue structures. Therefore, it is suitable for the fast and efficient analysis of high numbers of fully digitalized histologic sections, potentially allowing "high-throughput" quantitative "histomic" analysis.

  14. Recent Progress on Labfit: a Multispectrum Analysis Program for Fitting Lineshapes Including the Htp Model and Temperature Dependence

    Science.gov (United States)

    Cich, Matthew J.; Guillaume, Alexandre; Drouin, Brian; Benner, D. Chris

    2017-06-01

    Multispectrum analysis can be a challenge for a variety of reasons. It can be computationally intensive to fit a proper line shape model especially for high resolution experimental data. Band-wide analyses including many transitions along with interactions, across many pressures and temperatures are essential to accurately model, for example, atmospherically relevant systems. Labfit is a fast multispectrum analysis program originally developed by D. Chris Benner with a text-based interface. More recently at JPL a graphical user interface was developed with the goal of increasing the ease of use but also the number of potential users. The HTP lineshape model has been added to Labfit keeping it up-to-date with community standards. Recent analyses using labfit will be shown to demonstrate its ability to competently handle large experimental datasets, including high order lineshape effects, that are otherwise unmanageable.

  15. WIND PROTECTION OF LANDSCAPE ARCHITECTURE

    Directory of Open Access Journals (Sweden)

    Trubitsyna Natalja Anatolevna

    2017-07-01

    Full Text Available The article discusses the interaction between the wind regime and the landscape. Examples of objects of landscape architecture in high-tech and science-intensive spheres, such as the launch pad of a spacecraft, are given. Wind protection is represented as a result of work on wind power engineering and a means of increasing bioclimatic comfort. The terms of landscape architecture are disclosed and mutual influence on the climate and impact on woody-shrub vegetation and field crops are analyzed. The phenomenon of air permeability for optimal operation of windproof structures and orientations of geoplastics and dendroplastics is described. In this paper, a classification of terrain types is described with a description of their elemental composition, as well as various categories of landscape. The proposal to consider the landscape as a territorial complex, and landscape buildings, landscape-architectural structures as objects of landscape architecture possessing properties of wind protection and air permeability was introduced. Thus, the concept of a landscape-architectural complex as a single group of landscape-architectural objects located on the territory and connected by a common system of communications, functions, technical elements and a visual image is formulated. Further research is based on the rationale for the use of the term ensemble in relation to the objects of the landscape and architectural complex and the identification of their design and planning features that can affect the parameters of wind protection and air permeability. The paper concludes that frequent coincidence of favorable for the fauna wind regime and mimicry of landscape architecture objects. The combination in the landscape of functions for wind protection and aesthetics is analyzed with analysis of such elements of landscape architecture as hedges and windproof properties of green plantations. In the work examples of wind engineering small architectural forms are

  16. Incorporating Resource Protection Constraints in an Analysis of Landscape Fuel-Treatment Effectiveness in the Northern Sierra Nevada, CA, USA

    Science.gov (United States)

    Dow, Christopher B.; Collins, Brandon M.; Stephens, Scott L.

    2016-03-01

    Finding novel ways to plan and implement landscape-level forest treatments that protect sensitive wildlife and other key ecosystem components, while also reducing the risk of large-scale, high-severity fires, can prove to be difficult. We examined alternative approaches to landscape-scale fuel-treatment design for the same landscape. These approaches included two different treatment scenarios generated from an optimization algorithm that reduces modeled fire spread across the landscape, one with resource-protection constrains and one without the same. We also included a treatment scenario that was the actual fuel-treatment network implemented, as well as a no-treatment scenario. For all the four scenarios, we modeled hazardous fire potential based on conditional burn probabilities, and projected fire emissions. Results demonstrate that in all the three active treatment scenarios, hazardous fire potential, fire area, and emissions were reduced by approximately 50 % relative to the untreated condition. Results depict that incorporation of constraints is more effective at reducing modeled fire outputs, possibly due to the greater aggregation of treatments, creating greater continuity of fuel-treatment blocks across the landscape. The implementation of fuel-treatment networks using different planning techniques that incorporate real-world constraints can reduce the risk of large problematic fires, allow for landscape-level heterogeneity that can provide necessary ecosystem services, create mixed forest stand structures on a landscape, and promote resilience in the uncertain future of climate change.

  17. Fitness Club

    CERN Multimedia

    Fitness Club

    2012-01-01

    Get in Shape for Summer with the CERN Fitness Club Saturday 23 June 2012 from 14:30 to 16.30 (doors open at 14.00) Germana’s Fitness Workshop. Build strength and stamina, sculpt and tone your body and get your heart pumping with Germana’s workout mixture of Cardio Attack, Power Pump, Power Step, Cardio Combat and Cross-Training. Where: 216 (Pump room – equipped with changing rooms and showers). What to wear: comfortable clothes and indoor sports shoes + bring a drink! How much: 15 chf Sign up here: https://espace.cern.ch/club-fitness/Lists/Test_Subscription/NewForm.aspx? Join the Party and dance yourself into shape at Marco + Marials Zumba Masterclass. Saturday 30 June 2012 from 15:00 to 16:30 Marco + Mariel’s Zumba Masterclass Where: 216 (Pump room – equipped with changing rooms and showers). What to wear: comfortable clothes and indoor sports shoes + bring a drink! How much: 25 chf Sign up here: https://espace.cern.ch/club-fitness/Lists/Zumba%20...

  18. Fitness Club

    CERN Multimedia

    Fitness Club

    2012-01-01

      The CERN Fitness Club is pleased to announce its new early morning class which will be taking place on: Tuesdays from 24th April 07:30 to 08:15 216 (Pump Hall, close to entrance C) – Facilities include changing rooms and showers. The Classes: The early morning classes will focus on workouts which will help you build not only strength and stamina, but will also improve your balance, and coordination. Our qualified instructor Germana will accompany you throughout the workout  to ensure you stay motivated so you achieve the best results. Sign up and discover the best way to start your working day full of energy! How to subscribe? We invite you along to a FREE trial session, if you enjoy the activity, please sign up via our website: https://espace.cern.ch/club-fitness/Activities/SUBSCRIBE.aspx. * * * * * * * * Saturday 28th April Get in shape for the summer at our fitness workshop and zumba dance party: Fitness workshop with Germana 13:00 to 14:30 - 216 (Pump Hall) Price...

  19. Fitness club

    CERN Multimedia

    Fitness club

    2013-01-01

      Nordic Walking Classes Come join the Nordic walking classes and outings offered by the CERN Fitness Club starting September 2013. Our licensed instructor Christine offers classes for people who’ve never tried Nordic Walking and who would like to learn the technique, and outings for people who have completed the classes and enjoy going out as a group. Course 1: Tuesdays 12:30 - 13:30 24 September, 1 October, 8 October, 15 October Course 2: Tuesdays 12:30 - 13:30 5 November, 12 November, 19 November, 26 November Outings will take place on Thursdays (12:30 to 13:30) from 12 September 2013. We meet at the CERN Club Barracks car park (close to Entrance A) 10 minutes before departure. Prices: 50 CHF for 4 classes, including the 10 CHF Club membership. Payments made directly to instructor. Renting Poles: Poles can be rented from Christine at 5 CHF / hour. Subscription: Please subscribe at: http://cern.ch/club-fitness Looking forward to seeing you among us! Fitness Club FitnessClub@c...

  20. Fitness analysis method for magnesium in drinking water with atomic absorption using quadratic curve calibration

    Directory of Open Access Journals (Sweden)

    Esteban Pérez-López

    2014-11-01

    Full Text Available Because of the importance of quantitative chemical analysis in research, quality control, sales of services and other areas of interest , and the limiting of some instrumental analysis methods for quantification with linear calibration curve, sometimes because the short linear dynamic ranges of the analyte, and sometimes by limiting the technique itself, is that there is a need to investigate a little more about the convenience of using quadratic curves for analytical quantification, which seeks demonstrate that it is a valid calculation model for chemical analysis instruments. To this was taken as an analysis method based on the technique and atomic absorption spectroscopy in particular a determination of magnesium in a sample of drinking water Tacares sector Northern Grecia, employing a nonlinear calibration curve and a curve specific quadratic behavior, which was compared with the test results obtained for the same analysis with a linear calibration curve. The results show that the methodology is valid for the determination referred to, with all confidence, since the concentrations are very similar, and as used hypothesis testing can be considered equal.

  1. Radial-velocity fitting challenge. II. First results of the analysis of the data set

    Science.gov (United States)

    Dumusque, X.; Borsa, F.; Damasso, M.; Díaz, R. F.; Gregory, P. C.; Hara, N. C.; Hatzes, A.; Rajpaul, V.; Tuomi, M.; Aigrain, S.; Anglada-Escudé, G.; Bonomo, A. S.; Boué, G.; Dauvergne, F.; Frustagli, G.; Giacobbe, P.; Haywood, R. D.; Jones, H. R. A.; Laskar, J.; Pinamonti, M.; Poretti, E.; Rainer, M.; Ségransan, D.; Sozzetti, A.; Udry, S.

    2017-02-01

    threshold to attest the veracity of planetary signals for RV measurements with similar properties to those of the different RV fitting challenge systems. Based on observations collected at the La Silla Parana Observatory, ESO (Chile), with the HARPS spectrograph at the 3.6-m telescope.

  2. Sustaining ecosystem services in cultural landscapes

    Directory of Open Access Journals (Sweden)

    Tobias Plieninger

    2014-06-01

    Full Text Available Classical conservation approaches focus on the man-made degradation of ecosystems and tend to neglect the social-ecological values that human land uses have imprinted on many environments. Throughout the world, ingenious land-use practices have generated unique cultural landscapes, but these are under pressure from agricultural intensification, land abandonment, and urbanization. In recent years, the cultural landscapes concept has been broadly adopted in science, policy, and management. The interest in both outstanding and vernacular landscapes finds expression in the UNESCO World Heritage Convention, the European Landscape Convention, and the IUCN Protected Landscape Approach. These policies promote the protection, management, planning, and governance of cultural landscapes. The ecosystem services approach is a powerful framework to guide such efforts, but has rarely been applied in landscape research and management. With this paper, we introduce a special feature that aims to enhance the theoretical, empirical and practical knowledge of how to safeguard the resilience of ecosystem services in cultural landscapes. It concludes (1 that the usefulness of the ecosystem services approach to the analysis and management of cultural landscapes should be reviewed more critically; (2 that conventional ecosystem services assessment needs to be complemented by socio-cultural valuation; (3 that cultural landscapes are inherently changing, so that a dynamic view on ecosystem services and a focus on drivers of landscape change are needed; and (4 that managing landscapes for ecosystem services provision may benefit from a social-ecological resilience perspective.

  3. Why dichotomies can be misleading while dualities fit the analysis of complex phenomena.

    Science.gov (United States)

    Branco, Angela Uchoa

    2009-12-01

    Humans' tendency to classify and categorize is definitely overspread, but it can be misleading at all fields, including epistemology, ontology, theory, and analysis of scientific knowledge construction itself. Sanchez and Loredo (IPBS: Integrative Psychological & Behavioral Science 43:4, 2009-DOI 10.1007/s12124-009-9091-1) in their article on classification of contemporary constructivists fall exactly into such pitfall- even as their effort to make sense of many outstanding theorists is impressive and inriguing. A further analysis, however, points at the theoretical trap posed by such endeavor, for models arisen from different epistemological standpoints cannot be compared along the lines of a simplistic polarity between "objectivism" and "subjectivism". There is much more to be taken into account when a intrinsically complex subject like constructivism and constructionism epistemological approach and their welcome different versions--perspectives--are submitted to analysis and critical evaluation.

  4. Cognitive fitness.

    Science.gov (United States)

    Gilkey, Roderick; Kilts, Clint

    2007-11-01

    Recent neuroscientific research shows that the health of your brain isn't, as experts once thought, just the product of childhood experiences and genetics; it reflects your adult choices and experiences as well. Professors Gilkey and Kilts of Emory University's medical and business schools explain how you can strengthen your brain's anatomy, neural networks, and cognitive abilities, and prevent functions such as memory from deteriorating as you age. The brain's alertness is the result of what the authors call cognitive fitness -a state of optimized ability to reason, remember, learn, plan, and adapt. Certain attitudes, lifestyle choices, and exercises enhance cognitive fitness. Mental workouts are the key. Brain-imaging studies indicate that acquiring expertise in areas as diverse as playing a cello, juggling, speaking a foreign language, and driving a taxicab expands your neural systems and makes them more communicative. In other words, you can alter the physical makeup of your brain by learning new skills. The more cognitively fit you are, the better equipped you are to make decisions, solve problems, and deal with stress and change. Cognitive fitness will help you be more open to new ideas and alternative perspectives. It will give you the capacity to change your behavior and realize your goals. You can delay senescence for years and even enjoy a second career. Drawing from the rapidly expanding body of neuroscience research as well as from well-established research in psychology and other mental health fields, the authors have identified four steps you can take to become cognitively fit: understand how experience makes the brain grow, work hard at play, search for patterns, and seek novelty and innovation. Together these steps capture some of the key opportunities for maintaining an engaged, creative brain.

  5. Analysis of magnetic measurement data by least squares fit to series expansion solution of 3-D Laplace equation

    Energy Technology Data Exchange (ETDEWEB)

    Blumberg, L.N. [Brookhaven National Lab., Upton, NY (United States). National Synchrotron Light Source

    1992-03-01

    The authors have analyzed simulated magnetic measurements data for the SXLS bending magnet in a plane perpendicular to the reference axis at the magnet midpoint by fitting the data to an expansion solution of the 3-dimensional Laplace equation in curvilinear coordinates as proposed by Brown and Servranckx. The method of least squares is used to evaluate the expansion coefficients and their uncertainties, and compared to results from an FFT fit of 128 simulated data points on a 12-mm radius circle about the reference axis. They find that the FFT method gives smaller coefficient uncertainties that the Least Squares method when the data are within similar areas. The Least Squares method compares more favorably when a larger number of data points are used within a rectangular area of 30-mm vertical by 60-mm horizontal--perhaps the largest area within the 35-mm x 75-mm vacuum chamber for which data could be obtained. For a grid with 0.5-mm spacing within the 30 x 60 mm area the Least Squares fit gives much smaller uncertainties than the FFT. They are therefore in the favorable position of having two methods which can determine the multipole coefficients to much better accuracy than the tolerances specified to General Dynamics. The FFT method may be preferable since it requires only one Hall probe rather than the four envisioned for the least squares grid data. However least squares can attain better accuracy with fewer probe movements. The time factor in acquiring the data will likely be the determining factor in choice of method. They should further explore least squares analysis of a Fourier expansion of data on a circle or arc of a circle since that method gives coefficient uncertainties without need for multiple independent sets of data as needed by the FFT method.

  6. Assessing Model Fit: Caveats and Recommendations for Confirmatory Factor Analysis and Exploratory Structural Equation Modeling

    Science.gov (United States)

    Perry, John L.; Nicholls, Adam R.; Clough, Peter J.; Crust, Lee

    2015-01-01

    Despite the limitations of overgeneralizing cutoff values for confirmatory factor analysis (CFA; e.g., Marsh, Hau, & Wen, 2004), they are still often employed as golden rules for assessing factorial validity in sport and exercise psychology. The purpose of this study was to investigate the appropriateness of using the CFA approach with these…

  7. Cuban Landscapes

    DEFF Research Database (Denmark)

    Scarpaci, Joseph L.; Portela, Armando

    (cubanidad), and vice versa. They provide a unique perspective on Cuba’s distinct historical periods and political economies, from the colonial period through republicanism and today’s socialist era. Compelling topics include the legacies of slavery and the sugar industry, the past and future of urban......This accessible book offers a vivid geographic portrait of Cuba, exploring the island’s streetscapes, sugar cane fields, beaches, and rural settlements; its billboards, government buildings, and national landmarks. The authors illuminate how natural and built landscapes have shaped Cuban identity...

  8. Cuban Landscapes

    DEFF Research Database (Denmark)

    Scarpaci, Joseph L.; Portela, Armando

    This accessible book offers a vivid geographic portrait of Cuba, exploring the island’s streetscapes, sugar cane fields, beaches, and rural settlements; its billboards, government buildings, and national landmarks. The authors illuminate how natural and built landscapes have shaped Cuban identity...... (cubanidad), and vice versa. They provide a unique perspective on Cuba’s distinct historical periods and political economies, from the colonial period through republicanism and today’s socialist era. Compelling topics include the legacies of slavery and the sugar industry, the past and future of urban...

  9. One Size Does Not Fit All: Human Failure Event Decomposition and Task Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ronald Laurids Boring, PhD

    2014-09-01

    In the probabilistic safety assessments (PSAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered or exacerbated by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question remains central as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PSAs tend to be top-down—defined as a subset of the PSA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) are more likely to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications. In this paper, I first review top-down and bottom-up approaches for defining HFEs and then present a seven-step guideline to ensure a task analysis completed as part of human error identification decomposes to a level suitable for use as HFEs. This guideline illustrates an effective way to bridge the bottom-up approach with top-down requirements.

  10. The farmer as a landscape steward: Comparing local understandings of landscape stewardship, landscape values, and land management actions.

    Science.gov (United States)

    Raymond, Christopher M; Bieling, Claudia; Fagerholm, Nora; Martin-Lopez, Berta; Plieninger, Tobias

    2016-03-01

    We develop a landscape stewardship classification which distinguishes between farmers' understanding of landscape stewardship, their landscape values, and land management actions. Forty semi-structured interviews were conducted with small-holder (100 acres) in South-West Devon, UK. Thematic analysis revealed four types of stewardship understandings: (1) an environmental frame which emphasized the farmers' role in conserving or restoring wildlife; (2) a primary production frame which emphasized the farmers' role in taking care of primary production assets; (3) a holistic frame focusing on farmers' role as a conservationist, primary producer, and manager of a range of landscape values, and; (4) an instrumental frame focusing on the financial benefits associated with compliance with agri-environmental schemes. We compare the landscape values and land management actions that emerged across stewardship types, and discuss the global implications of the landscape stewardship classification for the engagement of farmers in landscape management.

  11. Football Fitness - a new version of football?

    DEFF Research Database (Denmark)

    Bennike, Søren; Wikman, Johan Michael; Ottesen, Laila Susanne

    2014-01-01

    This article explores a new Danish football-based activity for health called Football Fitness (FF). Data are from quantitative and qualitative methods, and the theoretical framework for the analysis of the organizational form of FF is the theory of path dependency (Mahoney) and first- and second......-order change (Watzlawick et al.). Theories of Pestoff concerning differences between state, market, and the civil society and theories of voluntary associations in a Danish context (Kaspersen & Ottesen; Ibsen & Seippel) are applied. This article indicates how FF is a result of the changing landscape of sport...... and argues that it can be beneficial to target sports organizations and include the expertise of non-profit sports clubs if the goal is to raise the physical activity level of the local community and make these long lasting. But the organizations need to consider how this is to be done. FF, established...

  12. Understanding The Decision Context: DPSIR, Decision Landscape, And Social Network Analysis

    Science.gov (United States)

    Establishing the decision context for a management problem is the critical first step for effective decision analysis. Understanding the decision context allow stakeholders and decision-makers to integrate the societal, environmental, and economic considerations that must be con...

  13. The Importance of Physical Fitness versus Physical Activity for Coronary Artery Disease Risk Factors: A Cross-Sectional Analysis.

    Science.gov (United States)

    Young, Deborah Rohm; Steinhardt, Mary A.

    1993-01-01

    This cross-sectional study examined relationships among physical fitness, physical activity, and risk factors for coronary artery disease (CAD) in male police officers. Data from screenings and physical fitness assessments indicated physical activity must be sufficient to influence fitness before obtaining statistically significant risk-reducing…

  14. Epigenetic Inheritance Across the Landscape

    Directory of Open Access Journals (Sweden)

    Amy Vaughn Whipple

    2016-10-01

    Full Text Available The study of epigenomic variation at the landscape-level in plants may add important insight to studies of adaptive variation. A major goal of landscape genomic studies is to identify genomic regions contributing to adaptive variation across the landscape. Heritable variation in epigenetic marks, resulting in transgenerational plasticity, can influence fitness-related traits. Epigenetic marks are influenced by the genome, the environment, and their interaction, and can be inherited independently of the genome. Thus, epigenomic variation likely influences the heritability of many adaptive traits, but the extent of this influence remains largely unknown. Here we summarize the relevance of epigenetic inheritance to ecological and evolutionary processes, and review the literature on landscape-level patterns of epigenetic variation. Landscape-level patterns of epigenomic variation in plants generally show greater levels of isolation by distance and isolation by environment then is found for the genome, but the causes of these patterns are not yet clear. Linkage between the environment and epigenomic variation has been clearly shown within a single generation, but demonstrating transgenerational inheritance requires more complex breeding and/or experimental designs. Transgenerational epigenetic variation may alter the interpretation of landscape genomic studies that rely upon phenotypic analyses, but should have less influence on landscape genomic approaches that rely upon outlier analyses or genome-environment associations. We suggest that multi-generation common garden experiments conducted across multiple environments will allow researchers to understand which parts of the epigenome are inherited, as well as to parse out the relative contribution of heritable epigenetic variation to the phenotype.

  15. Source-sink landscape theory and its ecological significance

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Exploring the relatiouships between landscape pattern and ecological processes is the key topic of landscape ecology,for which,a large number of indices as well as landscape pattern analysis model were developed.However,one problem faced by landscape ecologists is that it is hard to link the landscape indices with a specific ecological process.Linking landscape pattern and ecological processes has become a challenge for landscape ecologists."Source" and "sink" are common concepts used in air pollution research,by which the movement direction and pattern of different pollutants in air can be clearly identified.In fact,for any ecological process,the research can be considered as a balance between the source and the sink in space.Thus,the concepts of "source" and "sink" could be implemented to the research of landscape pattern and ecological processes.In this paper,a theory of sourcesink landscape was proposed,which include:(1) In the research of landscape pattern and ecological process,all landscape types can be divided into two groups,"source"landscape and "sink" landscape."Source" landscape contributes positively to the ecological process,while "sink" landscape is unhelpful to the ecological process.(2) Both landscapes are recognized with regard to the specific ecological process."Source" landscape in a target ecological process may change into a "sink"landscape as in another ecological process.Therefore,the ecological process should be determined before "source"or "sink" landscape were defined.(3) The key point to distinguish "source" landscape from "sink" landscape is to quantify the effect of landscape on ecological process.The positive effect is made by "source" landscape,and the negative effect by "sink" landscape.(4) For the same ecological process,the contribution of "source" landscapes may vary,and it is the same to the "sink"landscapes.It is required to determine the weight of each landscape type on ecological processes.(5) The sourcesink principle can be

  16. How does scientific risk assessment of GM crops fit within the wider risk analysis?

    Science.gov (United States)

    Johnson, Katy L; Raybould, Alan F; Hudson, Malcolm D; Poppy, Guy M

    2007-01-01

    The debate concerning genetically modified crops illustrates confusion between the role of scientists and that of wider society in regulatory decision making. We identify two fundamental misunderstandings, which, if rectified, would allow progress with confidence. First, scientific risk assessment needs to test well-defined hypotheses, not simply collect data. Second, risk assessments need to be placed in the wider context of risk analysis to enable the wider 'non-scientific' questions to be considered in regulatory decision making. Such integration and understanding is urgently required because the challenges to regulation will escalate as scientific progress advances.

  17. [Graphical procedures for assessing person-fit in item factor analysis].

    Science.gov (United States)

    Ferrando Piera, Pere Joan; Morales Vives, Fàbia

    2010-05-01

    Flagging the individuals who did not answer consistently can be very useful in certain applied domains, especially in clinical and personnel selection areas. Identification of inconsistent patterns prevents erroneous interpretations of test scores. Two graphic procedures based on linear factor analysis are proposed in this paper. They allow the possible causes of low intra-individual consistency to be assessed once a pattern has been flagged as inconsistent. Moreover, these procedures allow us to identify the items that have contributed the most to the inconsistency. The procedures are illustrated with some empirical examples in personality. Lastly, implications of the results in the construction of personality measures are discussed.

  18. Fitness Club

    CERN Multimedia

    Fitness Club

    2012-01-01

    Nordic Walking Classes Sessions of four classes of one hour each are held on Tuesdays. RDV barracks parking at Entrance A, 10 minutes before class time. Session 1 =  11.09 / 18.09 / 25.09 / 02.10, 18:15 - 19:15 Session 2 = 25.09 / 02.10 / 09.10 / 16.10, 12:30 - 13:30 Session 3 = 23.10 / 30.10 / 06.11 / 13.11, 12:30 - 13:30 Session 4 = 20.11 / 27.11 / 04.12 / 11.12, 12:30 - 13:30 Prices 40 CHF per session + 10 CHF club membership 5 CHF/hour pole rental Check out our schedule and enroll at http://cern.ch/club-fitness   Hope to see you among us!  fitness.club@cern.ch In spring 2012 there was a long-awaited progress in CERN Fitness club. We have officially opened a Powerlifting @ CERN, and the number of members of the new section has been increasing since then reaching 70+ people in less than 4 months. Powerlifting is a strength sport, which is simple as 1-2-3 and efficient. The "1-2-3" are the three basic lifts (bench press...

  19. Reconstructing the free-energy landscape of Met-enkephalin using dihedral Principal Component Analysis and Well-tempered Metadynamics

    CERN Document Server

    Sicard, Francois

    2012-01-01

    Well-Tempered Metadynamics (WTmetaD) is an efficient method to enhance the reconstruction of the free-energy surface of proteins. WTmetaD guarantees a faster convergence in the long time limit in comparison with the standard metadynamics. It still suffers however from the same limitation, i.e. the non trivial choice of pertinent collective variables (CVs). To circumvent this problem, we couple WTmetaD with a set of CVs generated from a dihedral Principal Component Analysis (dPCA) on the Ramachadran dihedral angles describing the backbone structure of the protein. The dPCA provides a generic method to extract relevant CVs built from internal coordinates. We illustrate the robustness of this method in the case of the small and very diffusive Metenkephalin pentapeptide, and highlight a criterion to limit the number of CVs necessary to biased the metadynamics simulation. The free-energy landscape (FEL) of Met-enkephalin built on CVs generated from dPCA is found rugged compared with the FEL built on CVs extracted ...

  20. Youth in crisis in the Middle East and North Africa: a systematic literature review and focused landscape analysis.

    Science.gov (United States)

    Fehling, M; Jarrah, Z M; Tiernan, M E; Albezreh, S; VanRooyen, M J; Alhokair, A; Nelson, B D

    2016-03-15

    Recent political and demographic factors have exposed the vulnerability of the youth in the Middle East and North Africa (MENA) region. This study aimed to elucidate the current needs, activities, stakeholders and solutions related to at-risk youth and young adults in the MENA region. A systematic literature review was conducted of the peer-reviewed and grey literature. This was complemented by an in-region landscape analysis involving key-informant interviews and focus group discussions. After extensive screening of 1160 unique articles, 275 articles were considered relevant to this study. Of these 275, 145 (52.7%) were related to health (64.8% of these related to mental health), 101 (36.7%) to livelihood, 87 (31.6%) to violence prevention and 68 (24.7%) to education. Important themes and challenges identified in the literature and discussions included the MENA region's growing youth bulge; youth unemployment; critical gender gaps; and the impact of conflict on livelihoods, education and health, especially mental health.

  1. Multi-scale analysis of relationship between landscape pattern and urban river water quality in different seasons

    Science.gov (United States)

    Xiao, Rui; Wang, Guofeng; Zhang, Qianwen; Zhang, Zhonghao

    2016-05-01

    Water quality is highly dependent on the landscape characteristics. In this study, we investigated the relationships between water quality and landscape pattern (composition and configuration) in Huzhou City, China. The water quality variables, including pH, dissolved oxygen (DO), chemical oxygen demand (CODMn), Biochemical Oxygen Demand (BOD), NH3-N, petroleum, dissolved total phosphorus (DTP), and total nitrogen (TN) in low water, normal water and flood periods were identified by investigating 34 sampling sites in Huzhou City during the period from 2001 to 2007. Landscape composition and landscape configuration metrics were calculated for different scales. It was found that scales and seasons both play important role when analyzing the relationships between landscape characteristics of different land use types. The results implied that some water quality parameters such as CODMn, petroleum are more polluted in flood period than the other two seasons at different scales, while DTP and TN are more polluted in low water period. Influences of different landscape metrics on water quality should operate at different spatial scales. The results shown in this paper will effectively provide scientific basis for the policy making in sustainable development of water environment.

  2. [Assessment of landscape ecological security and optimization of landscape pattern based on spatial principal component analysis and resistance model in arid inland area: A case study of Ganzhou District, Zhangye City, Northwest China].

    Science.gov (United States)

    Pan, Jing-hu; Liu, Xiao

    2015-10-01

    Starting from ecological environment of inland river in arid area, the distribution of ecological security pattern of Ganzhou District was obtained by using the theory of landscape ecology, spatial principal component analysis (SPCA) and GIS techniques. Ten factors such as altitude, slope, soil erosion, vegetation coverage, and distance from road, were selected as the constraint conditions. According to the minimum cumulative resistance (MCR) model of landscape, the ecological corridor and nodes were established to optimize the structure and function of ecological function network. The results showed that the comprehensive ecological security situation of the research area was on the average. Area of moderate level of security was 1318.7 km2, being the largest and accounting for 36.7% of the research area. The area of low level of security was mainly located in the northern part and accounted for 19.9% of the study area. With points, lines and surfaces being interlaced, a regional ecological network was constructed, which was consisted of six ecological corridor, 14 ecological nodes, a large ecological source region and a plurality of small area source region, and could effectively improve ecological security level of the study area.

  3. Analysis of Environmental Stress Factors Using an Artificial Growth System and Plant Fitness Optimization

    Directory of Open Access Journals (Sweden)

    Meonghun Lee

    2015-01-01

    Full Text Available The environment promotes evolution. Evolutionary processes represent environmental adaptations over long time scales; evolution of crop genomes is not inducible within the relatively short time span of a human generation. Extreme environmental conditions can accelerate evolution, but such conditions are often stress inducing and disruptive. Artificial growth systems can be used to induce and select genomic variation by changing external environmental conditions, thus, accelerating evolution. By using cloud computing and big-data analysis, we analyzed environmental stress factors for Pleurotus ostreatus by assessing, evaluating, and predicting information of the growth environment. Through the indexing of environmental stress, the growth environment can be precisely controlled and developed into a technology for improving crop quality and production.

  4. Analysis of environmental stress factors using an artificial growth system and plant fitness optimization.

    Science.gov (United States)

    Lee, Meonghun; Yoe, Hyun

    2015-01-01

    The environment promotes evolution. Evolutionary processes represent environmental adaptations over long time scales; evolution of crop genomes is not inducible within the relatively short time span of a human generation. Extreme environmental conditions can accelerate evolution, but such conditions are often stress inducing and disruptive. Artificial growth systems can be used to induce and select genomic variation by changing external environmental conditions, thus, accelerating evolution. By using cloud computing and big-data analysis, we analyzed environmental stress factors for Pleurotus ostreatus by assessing, evaluating, and predicting information of the growth environment. Through the indexing of environmental stress, the growth environment can be precisely controlled and developed into a technology for improving crop quality and production.

  5. Global fit analysis of myosin-5b motility reveals thermodynamics of Mg2+-sensitive acto-myosin-ADP states.

    Directory of Open Access Journals (Sweden)

    Igor Chizhov

    Full Text Available Kinetic and thermodynamic studies of the mechanochemical cycle of myosin motors are essential for understanding the mechanism of energy conversion. Here, we report our investigation of temperature and free Mg(2+-ion dependencies of sliding velocities of a high duty ratio class-5 myosin motor, myosin-5b from D. discoideum using in vitro motility assays. Previous studies have shown that the sliding velocity of class-5 myosins obeys modulation by free Mg(2+-ions. Free Mg(2+-ions affect ADP release kinetics and the dwell time of actin-attached states. The latter determines the maximal velocity of actin translocation in the sliding filament assay. We measured the temperature dependence of sliding velocity in the range from 5 to 55°C at two limiting free Mg(2+-ion concentrations. Arrhenius plots demonstrated non-linear behavior. Based on this observation we propose a kinetic model, which explains both sensitivity towards free Mg(2+-ions and non-linearity of the temperature dependence of sliding velocity. According to this model, velocity is represented as a simple analytical function of temperature and free Mg(2+-ion concentrations. This function has been applied to global non-linear fit analysis of three data sets including temperature and magnesium (at 20°C dependence of sliding velocity. As a result we obtain thermodynamic parameters (ΔH(Mg and ΔS(Mg of a fast equilibrium between magnesium free (AM·D and magnesium bound acto-myosin-ADP (AM· Mg(2+D states and the corresponding enthalpic barriers associated with ADP release (ΔH1(‡ and ΔH2(‡. The herein presented integrative approach of data analysis based on global fitting can be applied to the remaining steps of the acto-myosin ATPase cycle facilitating the determination of energetic parameters and thermodynamics of acto-myosin interactions.

  6. Metapopulations in agricultural landscapes: a spatially explicit trade-off analysis

    NARCIS (Netherlands)

    Groeneveld, R.A.; Grashof-Bokdam, C.J.; Ierland, van E.C.

    2005-01-01

    This paper presents a spatially explicit trade-off analysis of species conservation in agricultural areas. A spatially explicit model is presented that integrates an applied metapopulation model with a farm management model. The model is used to calculate production possibilities frontiers of net mo

  7. A Global Approach to Accurate and Automatic Quantitative Analysis of NMR Spectra by Complex Least-Squares Curve Fitting

    Science.gov (United States)

    Martin, Y. L.

    The performance of quantitative analysis of 1D NMR spectra depends greatly on the choice of the NMR signal model. Complex least-squares analysis is well suited for optimizing the quantitative determination of spectra containing a limited number of signals (20). From a general point of view it is concluded, on the basis of mathematical considerations and numerical simulations, that, in the absence of truncation of the free-induction decay, complex least-squares curve fitting either in the time or in the frequency domain and linear-prediction methods are in fact nearly equivalent and give identical results. However, in the situation considered, complex least-squares analysis in the frequency domain is more flexible since it enables the quality of convergence to be appraised at every resonance position. An efficient data-processing strategy has been developed which makes use of an approximate conjugate-gradient algorithm. All spectral parameters (frequency, damping factors, amplitudes, phases, initial delay associated with intensity, and phase parameters of a baseline correction) are simultaneously managed in an integrated approach which is fully automatable. The behavior of the error as a function of the signal-to-noise ratio is theoretically estimated, and the influence of apodization is discussed. The least-squares curve fitting is theoretically proved to be the most accurate approach for quantitative analysis of 1D NMR data acquired with reasonable signal-to-noise ratio. The method enables complex spectral residuals to be sorted out. These residuals, which can be cumulated thanks to the possibility of correcting for frequency shifts and phase errors, extract systematic components, such as isotopic satellite lines, and characterize the shape and the intensity of the spectral distortion with respect to the Lorentzian model. This distortion is shown to be nearly independent of the chemical species, of the nature of the molecular site, and of the type of nucleus, but

  8. Agrarian Landscape Management in a Modernized World

    DEFF Research Database (Denmark)

    Christensen, Andreas Aagaard

    processes within the Western world. Case landscapes in Denmark and New Zealand were selected based on a maximum variation sampling strategy, in order to be able to identify and analyse patterns of change manifesting across a variety of Western, modern agricultural landscapes. The thesis consists of : (1......) A historical analysis of social drivers of land use change affecting agrarian landscapes in the Western world in the period 1700-2000 based on a litterature review of modernization theory applied to two local scale historical case studies of changes in landscape structure; (2) A national scale analysis based...... land use patterns within the Western world based on historical cartographic evidence, (4) A local scale analysis of the decision making practices of landscape managers in four modern case landscapes in Denmark and New Zealand, based on interview surveys conducted in 2011 and 2012. Findings indicate...

  9. Timepix and FitPix detection system for RBS/C materials analysis

    CERN Document Server

    David-Bosne, Eric; Wahl, Ulrich

    This thesis reports the implementation of a Timepix position sensitive detector in a ion beam facility with a 0.5 mm collimated beam of 2MeV 1H$^{+}$ and 4He$^{+}$ for use in Rutherford Back-scattering Spectrometry channeling (RBS/C). A complete description is given of the methodology used for energy calibration, RBS data analysis and simulation with the FLUX Monte Carlo simulation program. Energy calibration was performed with internal test pulses and resulting resolution and accuracy were verified in two ways. The first time using a triple alpha source with the isotopes $^{239}$Pu, $^{241}$Am and $^{244}$Cm and secondly using a RBS spectrum of a thin film sample of Au/SiO$_{2}$/C. Setup characterization for channeling measurements was performed using single crystals of Si, 6H$^{-}$SiC and SrTiO$_{3}$. An energy resolution of 47.2 keV at 1862 keV for He$^{+}$ and an angular resolution of 0.11 (standard deviation) was achieved. Count rates as high as 2kHz were achieved with a frame rate of 15 frames/s. Higher...

  10. Strategic analysis of tuberculosis prevention and control actions in Brazil and Ethiopia: one size fits all?

    Science.gov (United States)

    Cardoso, Gisela; Dos Santos, Elizabeth Moreira; Kiflie, Yibeltal; Woldemichael, Kifle; Wilson, Suzanne; Lemma, Wuleta

    2017-03-01

    This study aimed at conducting a strategic analysis of Tuberculosis prevention and control actions in Brazil and Ethiopia, looking at the potential of directly observed treatment short-course strategy (DOTS) and community DOTS in both countries. Literature review was conducted using PubMed, Medline-Ovid, EMBASE, and SCIELO databases. The reviewed terms were Tuberculosis, prevention and control and Brazil (or Brasil) or Ethiopia (or Etiopia). Study's eligibility included article's title or abstract in English or Portuguese and comprised the following Tuberculosis policy components: management; care; communication, and social mobilization; training and professional development; epidemiological surveillance, and monitoring and evaluation. The study identified, compared, and analyzed the challenges and recommendations reported in the literature. Although DOTS was not able to address all the difficulties regarding Tuberculosis control and prevention, it contributes to overcome challenges identified in the literature review. Decentralizing DOTS in Ethiopia and implementing DOTS in Brazil were key recommendations to overcome problems of access and treatment default. DOTS and Community DOTS cannot solve every identified Tuberculosis challenge, but together they complement each other. Both strategies need to be tailored to site's challenges.

  11. Experience of fractal analysis of micromammal population in mosaic landscapes of Karelia

    Directory of Open Access Journals (Sweden)

    Korosov Andrey Victorovich

    2015-12-01

    Full Text Available The multifractal analysis of the community structure of small mammals which inhabit the areas with a long history of forest management was carried out on the basis of the investigations of 1996-2015. Scaling showed deterioration of the self-similarity of theriocenozis, while scaling down ( reducing the volume of the sample. In our opinion, this is due to the asymmetric reaction of different types of animals in the secondary anthropogenic mosaic of habitats. To obtain meaningful results it is necessary to possess unattainably great amount of data. The time elapsed to learn technology and calculations of multifractal analysis was not justified by the modesty of conclusions received in this study.

  12. Social Evaluation Approaches in Landscape Projects

    Directory of Open Access Journals (Sweden)

    Saverio Miccoli

    2014-11-01

    Full Text Available Landscape is a crucial component of world heritage and, in the last few years, landscape projects have played a vital role in the development of sustainable scenarios. As reported in the European Landscape Convention, landscape means an area, as perceived by people, of which the character is the result of the action and interaction of natural and/or human factors. Therefore, in landscape planning and assessment, the community is necessarily involved. In order to improve the effectiveness of a project for landscape enhancement, this study suggests strategies for an integrated project, taking into account the numerous, heterogeneous variables involved. A landscape project, therefore, is a complex project that requires structured valuation stages, open to the community dimension. The qualitative, intergenerational, and inclusive characteristics of landscapes suggest that the limits of traditional economic analysis should be exceeded by adopting new assessment methods. With this aim in mind, this paper proposes social evaluation approaches, which operate by combining deliberative processes with total economic and multidimensional approaches. In this paper, we present: (1 a brief overview of the main features and issues concerning landscape projects; (2 strategies for integrated projects in landscape enhancement; and (3 social approaches in landscape assessment that account for complexity and social inclusion.

  13. Data science education: a preliminary analysis of the U.S landscape

    Directory of Open Access Journals (Sweden)

    Renata Gonçalves Curty

    2016-08-01

    Full Text Available Introduction: Data scientists has received great attention in recent years following the demands of the labor market stimulated by the open science and big data era. Originally widespread in 2008 and, since then, present in many different industries and applications; data science was announced in 2012 as the most attractive and one of the best paid jobs of the century, culminating with an increasing supply of training courses. Objective: Characterize and understand the formative aspects of data scientists. Methodology: This article describes part of a survey research based on analysis of 93 degrees in data science offered by US institutions. Results: The content analysis of the information publicized on the websites of the identified programs provides evidence that this professional is trained to deal with issues related to the collection, treatment, processing, analysis, visualization and curation of large and heterogeneous data collections in order to solving real-life and practical problems. Conclusion: Findings also revealed that, in general, training in science data places great emphasis on statistical skills, mathematics and computing, including programming and advanced modeling, many of which are placed as prerequisites for admission in these programs.

  14. Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery.

    Science.gov (United States)

    Hoinka, Jan; Berezhnoy, Alexey; Dao, Phuong; Sauna, Zuben E; Gilboa, Eli; Przytycka, Teresa M

    2015-07-13

    High-Throughput (HT) SELEX combines SELEX (Systematic Evolution of Ligands by EXponential Enrichment), a method for aptamer discovery, with massively parallel sequencing technologies. This emerging technology provides data for a global analysis of the selection process and for simultaneous discovery of a large number of candidates but currently lacks dedicated computational approaches for their analysis. To close this gap, we developed novel in-silico methods to analyze HT-SELEX data and utilized them to study the emergence of polymerase errors during HT-SELEX. Rather than considering these errors as a nuisance, we demonstrated their utility for guiding aptamer discovery. Our approach builds on two main advancements in aptamer analysis: AptaMut-a novel technique allowing for the identification of polymerase errors conferring an improved binding affinity relative to the 'parent' sequence and AptaCluster-an aptamer clustering algorithm which is to our best knowledge, the only currently available tool capable of efficiently clustering entire aptamer pools. We applied these methods to an HT-SELEX experiment developing aptamers against Interleukin 10 receptor alpha chain (IL-10RA) and experimentally confirmed our predictions thus validating our computational methods. Published by Oxford University Press on behalf of Nucleic Acids Research 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  15. 景观认知偏好及其人群差异性分析%Landscape Cognitive Preference and Individual Difference Analysis

    Institute of Scientific and Technical Information of China (English)

    罗涛; 张婷; 王海; 甘永洪; 邱全毅

    2013-01-01

    Taking Houguan Lake, Wuhan as the case area, cognitive preference of subjects to 3 landscape types/12 elements was evaluated by AHP, and their individual differences were also analyzed.Results indicated that the subjects show different degree of preferences on different landscape types or elements.They generally prefer natural landscape most especially landscape elements including water and trees, followed by semi-natural landscape and artificial landscape.Obvious difference exists in cognitive preference of different subjects to natural landscape types.Different subjects have similar cognitive preference to artificial landscape.The cognitive preference values are affected by the subjects' gender, age, living area, education background, vocation and professional background, with the influence degree from high to low as age, vocation, living area, professional background, education background and gender.According to analysis results of individual difference of cognitive preference, the subjects who prefer natural landscape have some features in common, that is female, younger than 45 years' old, living in urban area, bachelor or above degree, working indoor, and with professional background of landscape or equivalent.%以武汉市后官湖地区为例,采用层次分析法(AHP)测试了人们对该区域内3种景观类型、12类景观元素的认知偏好情况,并初步分析了景观认知偏好的人群差异性.结果表明:(1)样本人群对不同的景观类型和景观元素表现出不同程度的偏好,并且普遍偏好自然景观(尤其是包含水体和与树木有关的景观元素),其次是半自然景观,最次是人工景观;(2)不同个体对于自然景观的认知偏好表现出明显的差异性,而对于人工景观,样本人群的认知偏好评价较为一致;(3)样本人群的性别、年龄、地区、受教育程度、职业及专业背景均会对个体的景观认知偏好产生不同程度的影响,影响程度从大到小依次

  16. Fitness club

    CERN Multimedia

    Fitness club

    2013-01-01

    Nordic Walking Classes New session of 4 classes of 1 hour each will be held on Tuesdays in May 2013. Meet at the CERN barracks parking at Entrance A, 10 minutes before class time. Dates and time: 07.05, 14.05, 21.05 and 28.05, fom  12 h 30 to 13 h 30 Prices: 40 CHF per session + 10 CHF club membership – 5 CHF / hour pole rental Check out our schedule and enroll at http://cern.ch/club-fitness Hope to see you among us! 

  17. Genetic analysis of a rat model of aerobic capacity and metabolic fitness.

    Directory of Open Access Journals (Sweden)

    Yu-Yu Ren

    Full Text Available Aerobic capacity is a strong predictor of all-cause mortality and can influence many complex traits. To explore the biological basis underlying this connection, we developed via artificial selection two rat lines that diverge for intrinsic (i.e. inborn aerobic capacity and differ in risk for complex disease traits. Here we conduct the first in-depth pedigree and molecular genetic analysis of these lines, the high capacity runners (HCR and low capacity runners (LCR. Our results show that both HCR and LCR lines maintain considerable narrow-sense heritability (h(2 for the running capacity phenotype over 28 generations (h(2 = 0.47 ± 0.02 and 0.43 ± 0.02, respectively. To minimize inbreeding, the lines were maintained by rotational mating. Pedigree records predict that the inbreeding coefficient increases at a rate of <1% per generation, ~37-38% slower than expected for random mating. Genome-wide 10K SNP genotype data for generations 5, 14, and 26 demonstrate substantial genomic evolution: between-line differentiation increased progressively, while within-line diversity deceased. Genome-wide average heterozygosity decreased at a rate of <1% per generation, consistent with pedigree-based predictions and confirming the effectiveness of rotational breeding. Linkage disequilibrium index r(2 decreases to 0.3 at ~3 Mb, suggesting that the resolution for mapping quantitative trait loci (QTL can be as high as 2-3 cM. To establish a test population for QTL mapping, we conducted an HCR-LCR intercross. Running capacity of the F1 population (n=176 was intermediate of the HCR and LCR parentals (28 pairs; and the F2 population (n=645 showed a wider range of phenotypic distribution. Importantly, heritability in the F0-F2 pedigree remained high (h(2~0.6. These results suggest that the HCR-LCR lines can serve as a valuable system for studying genomic evolution, and a powerful resource for mapping QTL for a host of characters relevant to human health.

  18. The contribution of Nintendo Wii Fit series in the field of health: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Julien Tripette

    2017-09-01

    Full Text Available Background Wii Fit was originally designed as a health and fitness interactive training experience for the general public. There are, however, many examples of Wii Fit being utilized in clinical settings. This article aims to identify the contribution of Wii Fit in the field of health promotion and rehabilitation by: (1 identifying the health-related domains for which the Wii Fit series has been tested, (2 clarifying the effect of Wii Fit in those identified health-related domains and (3 quantifying this effect. Method A systematic literature review was undertaken. The MEDLINE database and Games for Health Journal published content were explored using the search term “Wii-Fit.” Occurrences resulting from manual searches on Google and material suggested by experts in the field were also considered. Included articles were required to have measurements from Wii Fit activities for at least one relevant health indicator. The effect of Wii Fit interventions was assessed using meta-analyses for the following outcomes: activity-specific balance confidence score, Berg balance score (BBC and time-up-and-go test (TUG. Findings A total of 115 articles highlighted that the Wii Fit has been tested in numerous healthy and pathological populations. Out of these, only a few intervention studies have focused on the prevention of chronic diseases. A large proportion of the studies focus on balance training (N = 55. This systematic review highlights several potential benefits of Wii Fit interventions and these positive observations are supported by meta-analyses data (N = 25. For example, the BBC and the TUG respond to a similar extend to Wii Fit interventions compared with traditional training. Conclusion Wii Fit has the potential to be used as a rehabilitation tool in different clinical situations. However, the current literature includes relatively few randomized controlled trials in each population. Further research is therefore required.

  19. The application of GIS in the topoclimatic analysis of the landscape for the viticulture purposes

    Directory of Open Access Journals (Sweden)

    Igor Žiberna

    1992-12-01

    Full Text Available For the needs of the analysis of the positions of viticulture areas and thechanges between the years 1824 and 1985 we have made a simple GIS for two example areas in the Middle Slovenske gorice. The DEM 50x50 m was used for GIS as a basic data layer. With the help of certain topoclimatical data we have tried to make a map of climatical conveniend areas for the vineyard. The changes of viticultural areas between the years 1824 and 1985 are shown as well.

  20. Energy landscape investigation by wavelet transform analysis of atomic force spectroscopy data in a biorecognition experiment.

    Science.gov (United States)

    Bizzarri, Anna Rita

    2016-01-01

    Force fluctuations recorded in an atomic force spectroscopy experiment, during the approach of a tip functionalized with biotin towards a substrate charged with avidin, have been analyzed by a wavelet transform. The observation of strong transient changes only when a specific biorecognition process between the partners takes place suggests a drastic modulation of the force fluctuations when biomolecules recognize each other. Such an analysis allows to investigate the peculiar features of a biorecognition process. These results are discussed in connection with the possible role of energy minima explored by biomolecules during the biorecognition process.

  1. Invasion fitness, inclusive fitness, and reproductive numbers in heterogeneous populations.

    Science.gov (United States)

    Lehmann, Laurent; Mullon, Charles; Akçay, Erol; Van Cleve, Jeremy

    2016-08-01

    How should fitness be measured to determine which phenotype or "strategy" is uninvadable when evolution occurs in a group-structured population subject to local demographic and environmental heterogeneity? Several fitness measures, such as basic reproductive number, lifetime dispersal success of a local lineage, or inclusive fitness have been proposed to address this question, but the relationships between them and their generality remains unclear. Here, we ascertain uninvadability (all mutant strategies always go extinct) in terms of the asymptotic per capita number of mutant copies produced by a mutant lineage arising as a single copy in a resident population ("invasion fitness"). We show that from invasion fitness uninvadability is equivalently characterized by at least three conceptually distinct fitness measures: (i) lineage fitness, giving the average individual fitness of a randomly sampled mutant lineage member; (ii) inclusive fitness, giving a reproductive value weighted average of the direct fitness costs and relatedness weighted indirect fitness benefits accruing to a randomly sampled mutant lineage member; and (iii) basic reproductive number (and variations thereof) giving lifetime success of a lineage in a single group, and which is an invasion fitness proxy. Our analysis connects approaches that have been deemed different, generalizes the exact version of inclusive fitness to class-structured populations, and provides a biological interpretation of natural selection on a mutant allele under arbitrary strength of selection.

  2. Biomechanics of the press-fit phenomenon in dental implantology: an image-based finite element analysis

    Directory of Open Access Journals (Sweden)

    Frisardi Gianni

    2012-05-01

    Full Text Available Abstract Background A fundamental pre-requisite for the clinical success in dental implant surgery is the fast and stable implant osseointegration. The press-fit phenomenon occurring at implant insertion induces biomechanical effects in the bone tissues, which ensure implant primary stability. In the field of dental surgery, the understanding of the key factors governing the osseointegration process still remains of utmost importance. A thorough analysis of the biomechanics of dental implantology requires a detailed knowledge of bone mechanical properties as well as an accurate definition of the jaw bone geometry. Methods In this work, a CT image-based approach, combined with the Finite Element Method (FEM, has been used to investigate the effect of the drill size on the biomechanics of the dental implant technique. A very accurate model of the human mandible bone segment has been created by processing high resolution micro-CT image data. The press-fit phenomenon has been simulated by FE analyses for different common drill diameters (DA = 2.8 mm, DB = 3.3 mm, and DC = 3.8 mm with depth L = 12 mm. A virtual implant model has been assumed with a cylindrical geometry having height L = 11 mm and diameter D = 4 mm. Results The maximum stresses calculated for drill diameters DA, DB and DC have been 12.31 GPa, 7.74 GPa and 4.52 GPa, respectively. High strain values have been measured in the cortical area for the models of diameters DA and DB, while a uniform distribution has been observed for the model of diameter DC . The maximum logarithmic strains, calculated in nonlinear analyses, have been ϵ = 2.46, 0.51 and 0.49 for the three models, respectively. Conclusions This study introduces a very powerful, accurate and non-destructive methodology for investigating the effect of the drill size on the biomechanics of the dental implant technique. Further studies could aim at understanding how different drill

  3. Landscape as World Picture

    DEFF Research Database (Denmark)

    Wamberg, Jacob

    Age, among the powers-that-be. The topic of Volume II is the breakthrough of the modern landscape image and its new perspectival vistas, transient time and cultivated - or completely deserted - terrains. This post-medieval paradigm shift is construed as the mature stage in the evolution of self......-consciousness, with an urban individual contemplating nature at an aesthetic distance. Apart from being structurally equivalent with the new Copernican cosmos and the colonial expansion of Western culture, the new territorial landscape image is shown to develop in close interaction with the early modern work ethic...... from Palaeolithic cave paintings through to 19th-century modernity. A structuralist comparison between this pattern and three additional fields of analysis - self-consciousness, socially-determined perception of nature, and world picture - reveals a fascinating insight into culture's macrohistorical...

  4. Simulations of Fluvial Landscapes

    Science.gov (United States)

    Cattan, D.; Birnir, B.

    2013-12-01

    The Smith-Bretherton-Birnir (SBB) model for fluvial landsurfaces consists of a pair of partial differential equations, one governing water flow and one governing the sediment flow. Numerical solutions of these equations have been shown to provide realistic models in the evolution of fluvial landscapes. Further analysis of these equations shows that they possess scaling laws (Hack's Law) that are known to exist in nature. However, the simulations are highly dependent on the numerical methods used; with implicit methods exhibiting the correct scaling laws, but the explicit methods fail to do so. These equations, and the resulting models, help to bridge the gap between the deterministic and the stochastic theories of landscape evolution. Slight modifications of the SBB equations make the results of the model more realistic. By modifying the sediment flow equation, the model obtains more pronounced meandering rivers. Typical landsurface with rivers.

  5. Fitting Analysis using Differential evolution Optimization (FADO):. Spectral population synthesis through genetic optimization under self-consistency boundary conditions

    Science.gov (United States)

    Gomes, J. M.; Papaderos, P.

    2017-07-01

    The goal of population spectral synthesis (pss; also referred to as inverse, semi-empirical evolutionary- or fossil record approach) is to decipher from the spectrum of a galaxy the mass, age and metallicity of its constituent stellar populations. This technique, which is the reverse of but complementary to evolutionary synthesis, has been established as fundamental tool in extragalactic research. It has been extensively applied to large spectroscopic data sets, notably the SDSS, leading to important insights into the galaxy assembly history. However, despite significant improvements over the past decade, all current pss codes suffer from two major deficiencies that inhibit us from gaining sharp insights into the star-formation history (SFH) of galaxies and potentially introduce substantial biases in studies of their physical properties (e.g., stellar mass, mass-weighted stellar age and specific star formation rate). These are i) the neglect of nebular emission in spectral fits, consequently; ii) the lack of a mechanism that ensures consistency between the best-fitting SFH and the observed nebular emission characteristics of a star-forming (SF) galaxy (e.g., hydrogen Balmer-line luminosities and equivalent widths-EWs, shape of the continuum in the region around the Balmer and Paschen jump). In this article, we present fado (Fitting Analysis using Differential evolution Optimization) - a conceptually novel, publicly available pss tool with the distinctive capability of permitting identification of the SFH that reproduces the observed nebular characteristics of a SF galaxy. This so-far unique self-consistency concept allows us to significantly alleviate degeneracies in current spectral synthesis, thereby opening a new avenue to the exploration of the assembly history of galaxies. The innovative character of fado is further augmented by its mathematical foundation: fado is the first pss code employing genetic differential evolution optimization. This, in conjunction

  6. Comparative analysis of chromatin landscape in regulatory regions of human housekeeping and tissue specific genes

    Directory of Open Access Journals (Sweden)

    Dasgupta Dipayan

    2005-05-01

    Full Text Available Abstract Background Global regulatory mechanisms involving chromatin assembly and remodelling in the promoter regions of genes is implicated in eukaryotic transcription control especially for genes subjected to spatial and temporal regulation. The potential to utilise global regulatory mechanisms for controlling gene expression might depend upon the architecture of the chromatin in and around the gene. In-silico analysis can yield important insights into this aspect, facilitating comparison of two or more classes of genes comprising of a large number of genes within each group. Results In the present study, we carried out a comparative analysis of chromatin characteristics in terms of the scaffold/matrix attachment regions, nucleosome formation potential and the occurrence of repetitive sequences, in the upstream regulatory regions of housekeeping and tissue specific genes. Our data show that putative scaffold/matrix attachment regions are more abundant and nucleosome formation potential is higher in the 5' regions of tissue specific genes as compared to the housekeeping genes. Conclusion The differences in the chromatin features between the two groups of genes indicate the involvement of chromatin organisation in the control of gene expression. The presence of global regulatory mechanisms mediated through chromatin organisation can decrease the burden of invoking gene specific regulators for maintenance of the active/silenced state of gene expression. This could partially explain the lower number of genes estimated in the human genome.

  7. Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.

    Directory of Open Access Journals (Sweden)

    Stephen Gregory Addinall

    2011-04-01

    Full Text Available To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1 or containing a null mutation in the DNA damage response and telomere capping gene YKU70 (yku70Δ. We performed Quantitative Fitness Analysis (QFA on thousands of yeast strains containing mutations affecting telomere-capping proteins in combination with a library of systematic gene deletion mutations. To perform QFA, we typically inoculate 384 separate cultures onto solid agar plates and monitor growth of each culture by photography over time. The data are fitted to a logistic population growth model; and growth parameters, such as maximum growth rate and maximum doubling potential, are deduced. QFA reveals that as many as 5% of systematic gene deletions, affecting numerous functional classes, strongly interact with telomere capping defects. We show that, while Cdc13 and Yku70 perform complementary roles in telomere capping, their genetic interaction profiles differ significantly. At least 19 different classes of functionally or physically related proteins can be identified as interacting with cdc13-1, yku70Δ, or both. Each specific genetic interaction informs the roles of individual gene products in telomere biology. One striking example is with genes of the nonsense-mediated RNA decay (NMD pathway which, when disabled, suppress the conditional cdc13-1 mutation but enhance the null yku70Δ mutation. We show that the suppressing/enhancing role of the NMD pathway at uncapped telomeres is mediated through the levels of Stn1, an essential telomere capping protein, which interacts with Cdc13 and recruitment of telomerase to telomeres. We show that increased Stn1 levels affect growth of cells with telomere capping defects due to cdc13-1 and yku70Δ. QFA is a sensitive, high-throughput method that will also be useful to understand other

  8. The linguistic encoding of landscape in Lokono

    NARCIS (Netherlands)

    Rybka, K.A.

    2016-01-01

    This thesis investigates how landscape elements are expressed linguistically in Lokono (Arawakan). As a background to the analysis, an account of language vitality and a description of the grammar of space are given. The linguistic analysis of landscape starts with landform terms, which form a syste

  9. Screening for dioxin contamination in fish oil by PARAFAC and N-PLSR analysis of fluorescence landscapes

    DEFF Research Database (Denmark)

    Pedersen, Dorthe Kjær; Engelsen, Søren Balling

    2002-01-01

    A preliminary investigation of fish oils demonstrates that fluorescence excitation-emission landscapes evaluated by 3-way chemometric methods may be a candidate for an inexpensive screening method to indicate the level of contamination by dioxins and PCB’s which are normally analysed with expensive...... and time-consuming physicochemical separation techniques such as GC-MS. Fluorescence landscapes of 88 fish oils have been investigated and showed great variation due to species, season and treatment, depicting a variation in natural fluorescent components. The fluorescence landscapes were analysed...... by PARAFAC. Samples with similar fluorescence fingerprints were selected from a PARAFAC score plot and local significant prediction models with PARAFAC/MLR, N-PLSR and PLSR were established with correlation coefficients in the range from r=0.69 (n=10) to r=0.97 (n=75) for dioxin and r=0.92 (n=12) for PCB...

  10. Reading the Landscape: semitotics and landscape assessment

    Directory of Open Access Journals (Sweden)

    William Field

    1997-03-01

    Full Text Available The metaphor of the landscape as a text provides fertile ground for considering theories of linguistics as conceptual frameworks for interpreting and assessing landscapes. In this essay, some key propositions of semiotic theory, a branch of linguistics, are reviewed. Furthermore, the development from structuralist semiotics to post-structuralist ways of thinking is traced through the work of key semiotic proponents such as Roland Barthes and Umberto Eco. The findings of this review are compared with the approach taken in a recent New Zealand landscape assessment – the Canterbury Regional Landscape Study. The challenges presented by the multiple reading of a text, or landscape, are confronted in this landscape assessment without explicit reference to semiotic theory. Semiotic concepts such as polysemy, unlimited semiosis, semiotic fields and codification have the potential for making explicit the difficulties involved in the interpretation of landscapes.

  11. Landscape analysis for multi-hazard prevention in Orco and Soana valleys, North-Western Italy

    Science.gov (United States)

    Turconi, L.; Tropeano, D.; Savio, G.; De, S. Kumar; Mason, P. J.

    2015-04-01

    A Civil Protection Plan has been drafted for a 600 km2 mountainous region in NW Italy Consisting of Orco and Soana Valleys. It is a part of the oldest natural park in Italy and attracts several thousand tourists every year. The work is concerned with the analysis of relevant physiographic characteristics of this Alpine landscapehaving extremely variable geomorphology and possess a long history of instability. Thousands of records as well as digital maps (involving overlay and comparison of up to 90 GIS layers) have been analyzed and cross-correlated to find out the details of the events. The study area experienced different types of natural hazards, typical of the whole Alpine environment. Thus, the present area has been selected for such multi-hazard research in which several natural processes have been investigated, concerning their damaging effects over the land. Due to 36 different severe hazardous events at least 250 deaths have been recorded in the area since 18th Century, in the occasion of.

  12. Exploring the Visual Landscape

    NARCIS (Netherlands)

    Nijhuis, S.; Van Lammeren, R.; Van der Hoeven, F.

    2011-01-01

    Exploring the Visual Landscape is about the combination of landscape research and planning, visual perception and Geographic Information Science. It showcases possible ways of getting a grip on themes like: landscape openness, cluttering of the rural landscape, high-rise buildings in relation to

  13. Landscaping for energy efficiency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    This publication by the National Renewable Energy Laboratory addresses the use of landscaping for energy efficiency. The topics of the publication include minimizing energy expenses; landscaping for a cleaner environment; climate, site, and design considerations; planning landscape; and selecting and planting trees and shrubs. A source list for more information on landscaping for energy efficiency and a reading list are included.

  14. The effect of Tai Chi training on cardiorespiratory fitness in healthy adults: a systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Guohua Zheng

    Full Text Available Tai Chi may be efficient for healthy adults to improve the cardiorespiratory fitness, but there is no systematic evaluation for its effectiveness.To systematically assess the effectiveness of Tai Chi on cardiorespiratory fitness in healthy adults.Seven electronic databases were searched from their inception to October 2013. The controlled trails including randomized controlled trial (RCT, non-randomized controlled trial (NRCT, self-controlled trial (SCT, and cohort study (CS testing Tai Chi exercise against non-intervention control conditions in healthy adults that assessed any type cardiorespiratory fitness outcome measures were considered. Two reviewers independently performed the selection of the studies according to predefined criteria. The risk of bias was assessed using Cochrane criteria. RevMan 5.2 software was applied for data analysis.Twenty studies (2 RCTs, 8 NRCTs, 3 SCTs, and 7 CSs with 1868 participants were included, but most of them belonged to low methodological quality. The results of systematic review showed that Tai Chi exercise had positive effect on majority outcomes of cardio function (Blood pressure: n = 536, SPB SMD = -0.93, 95% CI -1.30 to -0.56, P < 0.00001; DBP SMD = -0.54, 95% CI -0.90 to -0.18, P < 0.00001; heart rate at quiet condition: n = 986, SMD = -0.72, 95% CI -1.27 to -0.18, P = 0.010; stroke volume: n = 583, SMD = 0.44, 95% CI 0.28 to 0.61, P < 0.00001; cardio output: n = 583, MD = 0.32 L/min, 95% CI 0.08 to 0.56, P = 0.009, lung capacity (FVC at quiet condition: n = 1272, MD = 359.16 mL, 95% CI 19.57 to 698.75, P = 0.04 for less than one year intervention, and MD = 442.46 mL, 95% CI 271.24 to 613.68, P<0.0001 for more than one year intervention; V·O2peak: n = 246, SMD = 1.33, 95% CI 0.97 to 1.70, P < 0.00001, and cardiorespiratory endurance (O2 pulse at quiet condition: n = 146, SMD = 1.04; 95% CI 0.69 to 1.39; P < 0.00001; stair test index at quiet condition: n = 679, SMD = 1.34, 95% CI 0.27 to 2.40, p = 0

  15. Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers.

    Directory of Open Access Journals (Sweden)

    Seong-Keun Yoo

    2016-08-01

    Full Text Available Follicular thyroid carcinoma (FTC and benign follicular adenoma (FA are indistinguishable by preoperative diagnosis due to their similar histological features. Here we report the first RNA sequencing study of these tumors, with data for 30 minimally invasive FTCs (miFTCs and 25 FAs. We also compared 77 classical papillary thyroid carcinomas (cPTCs and 48 follicular variant of PTCs (FVPTCs to observe the differences in their molecular properties. Mutations in H/K/NRAS, DICER1, EIF1AX, IDH1, PTEN, SOS1, and SPOP were identified in miFTC or FA. We identified a low frequency of fusion genes in miFTC (only one, PAX8-PPARG, but a high frequency of that in PTC (17.60%. The frequencies of BRAFV600E and H/K/NRAS mutations were substantially different in miFTC and cPTC, and those of FVPTC were intermediate between miFTC and cPTC. Gene expression analysis demonstrated three molecular subtypes regardless of their histological features, including Non-BRAF-Non-RAS (NBNR, as well as BRAF-like and RAS-like. The novel molecular subtype, NBNR, was associated with DICER1, EIF1AX, IDH1, PTEN, SOS1, SPOP, and PAX8-PPARG. The transcriptome of miFTC or encapsulated FVPTC was indistinguishable from that of FA, providing a molecular explanation for the similarly indolent behavior of these tumors. We identified upregulation of genes that are related to mitochondrial biogenesis including ESRRA and PPARGC1A in oncocytic follicular thyroid neoplasm. Arm-level copy number variations were correlated to histological and molecular characteristics. These results expanded the current molecular understanding of thyroid cancer and may lead to new diagnostic and therapeutic approaches to the disease.

  16. Comprehensive Analysis of the Transcriptional and Mutational Landscape of Follicular and Papillary Thyroid Cancers.

    Science.gov (United States)

    Yoo, Seong-Keun; Lee, Seungbok; Kim, Su-Jin; Jee, Hyeon-Gun; Kim, Byoung-Ae; Cho, Hyesun; Song, Young Shin; Cho, Sun Wook; Won, Jae-Kyung; Shin, Jong-Yeon; Park, Do Joon; Kim, Jong-Il; Lee, Kyu Eun; Park, Young Joo; Seo, Jeong-Sun

    2016-08-01

    Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable by preoperative diagnosis due to their similar histological features. Here we report the first RNA sequencing study of these tumors, with data for 30 minimally invasive FTCs (miFTCs) and 25 FAs. We also compared 77 classical papillary thyroid carcinomas (cPTCs) and 48 follicular variant of PTCs (FVPTCs) to observe the differences in their molecular properties. Mutations in H/K/NRAS, DICER1, EIF1AX, IDH1, PTEN, SOS1, and SPOP were identified in miFTC or FA. We identified a low frequency of fusion genes in miFTC (only one, PAX8-PPARG), but a high frequency of that in PTC (17.60%). The frequencies of BRAFV600E and H/K/NRAS mutations were substantially different in miFTC and cPTC, and those of FVPTC were intermediate between miFTC and cPTC. Gene expression analysis demonstrated three molecular subtypes regardless of their histological features, including Non-BRAF-Non-RAS (NBNR), as well as BRAF-like and RAS-like. The novel molecular subtype, NBNR, was associated with DICER1, EIF1AX, IDH1, PTEN, SOS1, SPOP, and PAX8-PPARG. The transcriptome of miFTC or encapsulated FVPTC was indistinguishable from that of FA, providing a molecular explanation for the similarly indolent behavior of these tumors. We identified upregulation of genes that are related to mitochondrial biogenesis including ESRRA and PPARGC1A in oncocytic follicular thyroid neoplasm. Arm-level copy number variations were correlated to histological and molecular characteristics. These results expanded the current molecular understanding of thyroid cancer and may lead to new diagnostic and therapeutic approaches to the disease.

  17. An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging.

    Directory of Open Access Journals (Sweden)

    Tian Yuan

    2015-02-01

    Full Text Available Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains unclear how much of this drift is functional or caused by underlying changes in cell subtype composition. Moreover, no study has yet comprehensively explored epigenetic drift at different genomic length scales and in relation to regulatory elements. Here we conduct an in-depth analysis of epigenetic drift in blood tissue. We demonstrate that most of the age-associated drift is independent of the increase in the granulocyte to lymphocyte ratio that accompanies aging and that enrichment of age-hypermethylated CpG islands increases upon adjustment for cellular composition. We further find that drift has only a minimal impact on in-cis gene expression, acting primarily to stabilize pre-existing baseline expression levels. By studying epigenetic drift at different genomic length scales, we demonstrate the existence of mega-base scale age-associated hypomethylated blocks, covering approximately 14% of the human genome, and which exhibit preferential hypomethylation in age-matched cancer tissue. Importantly, we demonstrate the feasibility of integrating Illumina 450k DNA methylation with ENCODE data to identify transcription factors with key roles in cellular development and aging. Specifically, we identify REST and regulatory factors of the histone methyltransferase MLL complex, whose function may be disrupted in aging. In summary, most of the epigenetic drift seen in blood is independent of changes in blood cell type composition, and exhibits patterns at different genomic length scales reminiscent of those seen in cancer. Integration of Illumina 450k with appropriate ENCODE data may represent a fruitful approach to identify transcription factors with key roles in aging and disease.

  18. Characterizing European cultural landscapes

    DEFF Research Database (Denmark)

    Tieskens, Koen F.; Schulp, Catharina J E; Levers, Christian

    2017-01-01

    European cultural landscapes are mostly characterized by only one of the dimensions. Our paper can help to identify pressures to cultural landscapes and thus to target measures for the conservation of these landscapes, to link similar landscapes in different regions, and to inform policy design on the most......Almost all rural areas in Europe have been shaped or altered by humans and can be considered cultural landscapes, many of which now are considered to entail valuable cultural heritage. Current dynamics in land management have put cultural landscapes under a huge pressure of agricultural...... intensification and land abandonment. To prevent the loss of cultural landscapes, knowledge on the location of different types of cultural landscapes is needed. In this paper, we present a characterization of European cultural landscapes based on the prevalence of three key dimensions of cultural landscapes...

  19. Landscape preference assessment of Louisiana river landscapes: a methodological study

    Science.gov (United States)

    Michael S. Lee

    1979-01-01

    The study pertains to the development of an assessment system for the analysis of visual preference attributed to Louisiana river landscapes. The assessment system was utilized in the evaluation of 20 Louisiana river scenes. Individuals were tested for their free choice preference for the same scenes. A statistical analysis was conducted to examine the relationship...

  20. 基于景观格局的福州LUCC与生态安全响应%LUCC Ecological Security Analysis of Fuzhou Based on Landscape Pattern

    Institute of Scientific and Technical Information of China (English)

    曾丽云; 韦素琼

    2011-01-01

    以1988年、2000年和2008年福州的土地利用数据为基础,基于GIS空间分析功能,以破碎度、分离度和优势度景观格局指数和景观类型脆弱度为指标,计算生态安全指数,评价研究区景观生态安全的变化趋势.研究结果表明:研究区景观结构变化导致生态安全指数随时间变化,耕地、林地景观生态安全指数有所下降,由于建设用地面积扩大,逐渐占据优势景观地类,由此计算出的区域整体生态安全指标上升.从景观指数看,耕地、林地、水域和未利用地的破碎度、分离度指数变化呈上升或不稳定状态,建设用地的破碎度和分离度指数有所减小;优势景观类型份额有所改变,建设用地对于区域景观的控制作用逐渐加强;景观干扰指数与生态安全指数存在负相关.%Based on the land use data of Fuzhou five districts in 1988, 2000 and 2008, supported by the function of GIS spatial analysis, and with the indexes of fragmentation, isolation and dominance, and of vulnerability of landscape types, it was introduced the indexes of ecological security to analyze that temporal characteristic of ecological security. The result shows: the change in landscape structure can strongly influence the indexes of ecological security in the region, which might result in the creasing of the degree of ecological security with the indexes of cultivated land and woodland landscape ecological security decreasing and construction land's contrary. The indexes of fragmentation and isolation of cultivated land, woodland, water area and unutilized land are increasing or unstable, and of the construction land decrease; the share of dominance landscape has changed and the control action of construction land to the landscape is being strong; the interference index of landscape and the index of ecological security are negative correlation.