WorldWideScience

Sample records for fifty year dose

  1. The next fifty years

    International Nuclear Information System (INIS)

    Scaldwell, Reg

    1995-01-01

    The General Manager of the reactor division of Centronics, a world class manufacturer of reactor control systems and radiation detectors, describes its achievements and looks forward to speculate on what the next fifty years may mean in terms of technological development. Tables are given of the locations of Centronics Fission Chambers and of reactors controlled with Centronic Detectors. (UK)

  2. Fifty years after Hiroshima

    International Nuclear Information System (INIS)

    Imai, R.

    1997-01-01

    Any discussion of the nuclear-proliferation regime in the post-Cold War era, its present role and expected function in the future must take into account the outcome of the New York Non-proliferation Treaty Review Conference held in 1995, and the four factors that shaped the twentieth century: fascism and communism, nuclear energy and environmental concerns, as well as the interaction between them. none of the factors can be handled within the boundaries of a single state. After fifty years of nuclear competition both for military and energy generation purposes, international conferences on disarmament, Non-proliferation Treaty, Comprehensive Test Ban Treaty, START negotiations and agreements, there are still remaining nuclear issues. Population growth, energy demands and supplies, all related to global environmental changes must be taken into account

  3. Fifty Years of Insulin

    African Journals Online (AJOL)

    has since saved millions of lives throughout the world. The year 197I is the 50th anniversary of Banting's historic discovery. The story of insulin ... He found no evidence of injury. An impaired ... Prize in medicine for his discovery of insulin.

  4. Fifty years of ILO

    International Nuclear Information System (INIS)

    1969-01-01

    'Poverty anywhere constitutes a danger to prosperity everywhere. This is the motto of the International Labour Organisation (ILO) which in June this year was celebrating the 50th anniversary of its foundation. It was initiated to advance the cause of social justice as a way of contributing to peace. (author)

  5. Fifty years of ILO

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1969-07-01

    'Poverty anywhere constitutes a danger to prosperity everywhere. This is the motto of the International Labour Organisation (ILO) which in June this year was celebrating the 50th anniversary of its foundation. It was initiated to advance the cause of social justice as a way of contributing to peace. (author)

  6. PAs: Fifty years young.

    Science.gov (United States)

    Mandel, Ellen D; North, Shannon

    2017-10-01

    The PA profession is 50 years young. Practicing PAs and current students hail from several generational categories ranging from Builders to Generation Z. This article reviews how different generations may have experienced PA program expansion, professional identity, state licensing, and prescription delegation. The authors sampled a cohort of PA program applicants about their views on what evokes optimism and concern for the PA profession. These themes mirror the recently paved professional road, while posing the all-important question: What construction lies on the horizon?

  7. Fifty years of Erlangen radiochemistry

    International Nuclear Information System (INIS)

    Morell, W.

    2007-01-01

    On June 29, 2006, the Radiochemical Laboratory of AREVA NP GmbH (formerly Siemens AG) in Erlangen celebrated its fiftieth anniversary. The occasion was marked by an event attended by more than 1,000 guests, among them Werner Gebauhr, the 85-year-old founder and first head of the Laboratory; the Managing Directors of AREVA NP GmbH, Ralf Gueldner and Ruediger Steuerlein; representatives of universities, research institutions, power utilities, and public authorities. The present head of the Radiochemical Laboratory, Wilfred Morell, sketched the highlights of the work performed over the past fifty years, which ranged from solid-state and very-high-purity materials technologies to development and service activities for nuclear technology. Manfred Erve, head of the Technical Center of AREVA NP GmbH, of which the Radiochemical Laboratory is a part, emphasized the changes in priorities over the past fifty years, which had always been met successfully by Radiochemistry. In the scientific part of the event, Wolfgang Schwarz (E.ON Kernkraftwerk GmbH, KKW Isar), Ulf Ilg (EnBW Kraftwerk AG, KKW Philippsburg), and Hans-Josef Allelein (Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH) explained 3 major subject areas in which Erlangen Radio-chemistry over many years has contributed basic findings (see other articles in this atw issue). On the occasion of the anniversary, a comprehensive booklet was published under the title of '50 Jahre Radiochemie Erlangen - 1956-2006'. (orig.)

  8. Fifty years with nuclear fission

    International Nuclear Information System (INIS)

    Behrens, J.W.; Carlson, A.D.

    1989-01-01

    The news of the discovery of nucler fission, by Otto Hahn and Fritz Strassmann in Germany, was brought to the United States by Niels Bohr in January 1939. Since its discovery, the United States, and the world for that matter, has never been the same. It therefore seemed appropriate to acknowledge the fiftieth anniversary of its discovery by holding a topical meeting entitled, ''Fifty years with nuclear fission,'' in the United States during the year 1989. The objective of the meeting was to bring together pioneers of the nuclear industry and other scientists and engineers to report on reminiscences of the past and on the more recent developments in fission science and technology. The conference highlighted the early pioneers of the nuclear industry by dedicating a full day (April 26), consisting of two plenary sessions, at the National Academy of Sciences (NAS) in Washington, DC. More recent developments in fission science and technology in addition to historical reflections were topics for two full days of sessions (April 27 and 28) at the main sites of the NIST in Gaithersburg, Maryland. The wide range of topics covered by Volume 2 of this topical meeting included plenary invited, and contributed sessions entitled, Nuclear fission -- a prospective; reactors II; fission science II; medical and industrial applications by by-products; reactors and safeguards; general research, instrumentation, and by-products; and fission data, astrophysics, and space applications. The individual papers have been cataloged separately

  9. Fifty years with nuclear fission

    International Nuclear Information System (INIS)

    Behrens, J.W.; Carlson, A.D.

    1989-01-01

    The news of the discovery of nuclear fission, by Otto Hahn and Fritz Strassmann in Germany, was brought to the United States by Niels Bohr in January 1939. Since its discovery, the United States, and the world for that matter, has never been the same. It therefore seemed appropriate to acknowledge the fifieth anniversary of its discovery by holding a topical meeting entitled, ''Fifty Years with Nuclear Fission,'' in the United States during the year 1989. The objective of the meeting was to bring together pioneers of the nuclear industry and other scientists and engineers to report on reminiscences of the past and on the more recent development in fission science and technology. The conference highlighted the early pioneers of the nuclear industry by dedicated a full day (April 26), consisting of two plenary sessions, at the National Academy of Sciences (NAS) in Washington, DC. More recent developments in fission science and technology in addition to historical reflections were topics for two fully days of sessions (April 27 and 28) at the main site of the NIST in Gaithersburg, Maryland. The wide range of topics covered in this Volume 1 by this topical meeting included plenary invited, and contributed sessions entitled: Preclude to the First Chain Reaction -- 1932 to 1942; Early Fission Research -- Nuclear Structure and Spontaneous Fission; 50 Years of Fission, Science, and Technology; Nuclear Reactors, Secure Energy for the Future; Reactors 1; Fission Science 1; Safeguards and Space Applications; Fission Data; Nuclear Fission -- Its Various Aspects; Theory and Experiments in Support of Theory; Reactors and Safeguards; and General Research, Instrumentation, and By-Product. The individual papers have been cataloged separately

  10. Fifty years of polymer science

    NARCIS (Netherlands)

    Du Prez, Filip; Hoogenboom, Richard; Klumperman, Bert; Meier, Michael; Monteiro, Michael; Müller, Alejandro; Vancso, Gyula J.

    2015-01-01

    The European Polymer Journal (EPJ) has been serving the scientific community for 50 years, which makes it one of the older macromolecular journals with a broad focus. Since its launch 50 years ago, EPJ has provided a distinguished forum for publications in polymer research, including chemistry,

  11. Fifty years of genetic load

    International Nuclear Information System (INIS)

    Wallace, B.

    1991-01-01

    This book discusses the radiation effects on Drosophila. It was originally thought that irradiating Drosophila would decrease the average fitness of the population, thereby leading to information about the detrimental effects of mutations. Surprisingly, the fitness of the irradiated population turned out to be higher than that of the control population. The original motivation for the experiment was as a test of genetic load theory. The average fitness of a population is depressed by deleterious alleles held in the population by the balance between mutation and natural selection. The depression is called the genetic load of the population. The load dose not depend on the magnitude of the deleterious effect of alleles, but only on the mutation rate

  12. Fifty years of radiological protection

    International Nuclear Information System (INIS)

    2007-01-01

    On 21 March 1957, the Steering Committee for Nuclear Energy of the Organisation for European Economic Co-operation established the Working Party on Public Health and Safety. From this early date onwards, radiological protection formed a central part of the work of what was to become the OECD Nuclear Energy Agency. Now, 50 years later, the Committee on Radiation Protection and Public Health (CRPPH) has commissioned this historical review of half a century of work and accomplishments. Over this period, the key topics in radiological protection have been identified, debated and addressed by the CRPPH. This report brings this history to life, presenting the major questions in the context of their time, and of the personalities who worked to address them. The developments and views of the past condition how we are able to assess and manage radiological risks today, as well as how we may adjust to challenges that will or could emerge in the coming years. This heritage is thus an important element for the CRPPH to consider as it looks forward to its next 50 years of accomplishments. (author)

  13. Fifty years of symmetry operations

    International Nuclear Information System (INIS)

    Wigner, E.P.

    1978-01-01

    The author begins by discussing the application of symmetry principles in classical physics, which began 150 years ago. He then offers a few remarks on the essence of these principles and their role in the structure of physics; events, laws of nature, and invariance principles - kinematic and then dynamic - are treated. After this general discussion of the various types of symmetries, he considers the fundamental differences in their application in classical and quantum physics; the symmetry principles have greater effectiveness in quantum theory. After a few critical remarks of a general nature on the invariance principles, the author reviews the application of symmetry principles in various areas of quantum mechanics: atomic spectra, molecular physics, solid state physics, nuclear physics, and particle physics. He notes that the role of the different symmetries recognized to be approximate provide the most interesting conclusions

  14. Fifty years of radiochemical tracers

    International Nuclear Information System (INIS)

    Evans, E.A.

    1992-01-01

    During the past 50 years radiochemical tracers, usually in the form of isotopically labelled organic compounds, have been essential tools to further advance our knowledge at the frontiers of a great variety of scientific developments in the life sciences. This plenary lecture reviews necessarily selected highlights in the synthesis and applications of such radiochemical tracers. Included are examples where important advances, made possible by using radiochemicals, have contributed to improving the quality of life on this planet. The principal radioisotopes involved, 14 C, 3 H, 35 S, 32 P, 125 I, are all relatively safe to handle and are commercially available at maximum theoretical specific activity (carrier free). The compounds labeled with these radioisotopes are used in many fields of research which include biosynthesis and biotechnology studies, cell biology, drug metabolism, clinical research and environmental applications, and are briefly reviewed. (author). 55 refs

  15. Homo cyborg: fifty years old

    Directory of Open Access Journals (Sweden)

    Chris Hables Gray

    2011-06-01

    Full Text Available While the term “cyborg” is only 50 years old, the process that has produced cyborgization is much older: the evolution of the human. Humans have evolved to modify ourselves and our environment, especially through evolving culture and the technologies it creates. Culture is part of nature. Today’s mundane i-cyborgs, military drones, intimate human-machine merging and genetic engineering are a result of this; which in turn produce feelings of uncanniness, hubris, and fear. Contemporary politics must take this complex dynamic into account if we are to secure a sustainable, survivable, future for ourselves and our descendents. Social experiments such as Burning Man are a prefiguration of the kinds of (self conscious techno-social creativity needed.

  16. Vannevar Bush: Fifty Years Later

    Science.gov (United States)

    Lagowski, J. J.

    1995-12-01

    It is ironic that the 50th anniversary year of Vannevar Bush's Report to President Truman entitled "Science the Endless Frontier", which put into motion the eminently successful current system of education of scientists in this country occurs at a time when serious questions are being asked about the usefulness of that very system. Bush viewed his proposal to establish a national research foundation (later to be called the National Science Foundation) as a "social compact." Judgment of scientific merit would be delegated to expert peers in return for scientific progress, which would ultimately benefit the nation in terms of scientific needs--military security, economic productivity, and enhanced quality of life. Bush wanted the funding of basic research intertwined with training, and preferred to use universities for this purpose rather than industrial or national labs. Bush viewed college and university scientists as teachers and investigators. He believed university-based research would uniquely encourage and engage the next generation of scientists as no other institutional arrangement could. Bush did not trust industry's commitment to basic research, an instinct that proved prophetic. The academic reserve of scientists (PhD's in training and postdoctoral students) that existed before World War II, and upon which the United States could draw for its needs, which were primarily associated with defense efforts, was probably one of the defining factors in Bush's suggested strategy. Currently, that reserve of talent has gotten so large that it is the obvious throttle in the pipeline slowing the continued development of the university research enterprise. Since 1977, the rate at which we have trained new scientists exceeds an average of 4% annually. Since 1987, the "science work force"--PhD's--has grown at three times the rate of the general labor supply. Temporary positions for postdoctoral scientists have grown even faster (over 5% per year since 1989). To compound

  17. Fifty years of Technical Cooperation

    International Nuclear Information System (INIS)

    2007-01-01

    The International Atomic Energy Agency (IAEA) was established in Vienna in 1957. The Statute of the IAEA, approved by 81 nations, founded the organization on three pillars: nuclear verification; safety and security; and the transfer of technology. Today, these three pillars still remain at the heart of the organization's work. However, the way in which the IAEA carries out this work, particularly with regard to technology transfer, has changed greatly over the years. When the IAEA opened for business, nuclear science and technology were in their infancy. Many Member States had no nuclear capacity at all. The IAEA's 'technical assistance' programme, as it was then known, was modest. Early projects were small in scale and short lived, focusing mainly on building human capacities and creating institutions and facilities that would support the introduction of nuclear technology in a safe and effective manner. Today, the picture is more complex. Instead of merely offering assistance, the IAEA focuses on cooperation for sustainable socioeconomic development, building on the skills and infrastructure that Member States have acquired over the past five decades. Member States are full partners in the process, guiding the IAEA's technical cooperation activities, setting national and regional priorities, and offering training opportunities and technical support to the IAEA and to other Member States. Technical cooperation between developing countries is facilitated and supported through regional cooperative agreements. Regional centres of expertise play an important role in sharing the benefits of nuclear science and technology among Member States

  18. Fifty years of shear zones

    Science.gov (United States)

    Graham, Rodney

    2017-04-01

    We are here, of course, because 1967 saw the publication of John Ramsay's famous book. Two years later a memorable field trip from Imperial College to the Outer Hebrides saw John on a bleak headland on the coast of North Uist where a relatively undeformed metadolerite within Lewisian (Precambrian) gneisses contained ductile shear zones with metamorphic fabrics in amphibolite facies. One particular outcrop was very special - a shear zone cutting otherwise completely isotropic, undeformed metadolerite, with an incremental foliation starting to develop at 45° to the deformation zone, and increasing in intensity as it approached the shear direction. Here was proof of the process of simple shear under ductile metamorphic conditions - the principles of simple shear outlined in John Ramsay's 1967 book clearly visible in nature, and verified by Ramsay's mathematical proofs in the eventual paper (Ramsay and Graham, 1970). Later work on the Lewisian on the mainland of Scotland, in South Harris, in Africa, and elsewhere applied Ramsay's simple shear principles more liberally, more imprecisely and on larger scale than at Caisteal Odair, but in retrospect it documented what seems now to be the generality of mid and lower crustal deformation. Deep seismic reflection data show us that on passive margins hyper-stretched continental crust (whether or not cloaked by Seaward Dipping Reflectors) seems to have collapsed onto the mantle. Crustal faults mostly sole out at or above the mantle - so the Moho is a detachment- an 'outer marginal detachment', if you like, and, of course, it must be a ductile shear. On non-volcanic margins this shear zone forms the first formed ocean floor before true sea floor spreading gets going to create real oceanic crust. Gianreto Manatschal, Marcel Lemoine and others realised that the serpentinites described in parts of the Alps are exposed remnants of this ductile shear zone. Associated ophicalcite breccias tell of sea floor exposure, while high

  19. Fifty years of nuclear magnetic resonance

    International Nuclear Information System (INIS)

    Martinez Valderrama, Juan Crisostomo

    1997-01-01

    Short information about the main developments of nuclear magnetic resonance during their fifty existence years is presented. Beside two examples of application (HETCOR and INADEQUATE) to the structural determination of organic compounds are described

  20. Information Systems Curricula: A Fifty Year Journey

    Science.gov (United States)

    Longenecker, Herbert E., Jr.; Feinstein, David; Clark, Jon D.

    2013-01-01

    This article presents the results of research to explore the nature of changes in skills over a fifty year period spanning the life of Information Systems model curricula. Work begun in 1999 was expanded both backwards in time, as well as forwards to 2012 to define skills relevant to Information Systems curricula. The work in 1999 was based on job…

  1. Fifty years ago - nuclear physics at Cambridge

    International Nuclear Information System (INIS)

    Burcham, W.E.

    1982-01-01

    Fifty years ago, the Cavendish saw the first nuclear transformations using artificially accelerated particles, and was soon to provide confirmation of the discovery of the positron. In 1932, the Cavendish Laboratory under the guiding hand of Rutherford was a world focus for research and with these discoveries saw the birth of modern particle physics. (orig.).

  2. Fifty years after Hiroshima and Nagasaki

    International Nuclear Information System (INIS)

    Nishiwaki, Y.

    1996-01-01

    factors such as those mentioned above must be considered in interpreting the effect of the atomic bombing, instead of ascribing all the effects solely to ionizing radiation. Fifty years ago, in 1945, the first three atomic bombs in human history were produced by the United States; one of these bombs was exploded experimentally at the testing ground in the desert 80 km from Alamogordo, New Mexico, on 16 July. The remaining two were used against Japan; the one called L ittle Boy , using Uranium 235 was dropped on Hiroshima on 6 August, the other F at Man , using Plutonium 239 on Nagasaki on 9 August, 1945

  3. First Fifty Years of Chemoresistive Gas Sensors

    Directory of Open Access Journals (Sweden)

    Giovanni Neri

    2015-01-01

    Full Text Available The first fifty years of chemoresistive sensors for gas detection are here reviewed, focusing on the main scientific and technological innovations that have occurred in the field over the course of these years. A look at advances made in fundamental and applied research and leading to the development of actual high performance chemoresistive devices is presented. The approaches devoted to the synthesis of novel semiconducting materials with unprecedented nanostructure and gas-sensing properties have been also presented. Perspectives on new technologies and future applications of chemoresistive gas sensors have also been highlighted.

  4. Nuclear fission discovered fifty years ago

    International Nuclear Information System (INIS)

    Weis, M.

    1988-01-01

    Fifty years ago, Otto Hahn, Lise Meitner and Fritz Strassmann discovered the process of nuclear fission which, more than other scientific discoveries to date, profoundly has changed the world and continues to influence our life significantly: This discovery made the up to then incontestable physicists' view of the atom as an inseparable whole suddenly shatter to pieces. It has brought about the invaluable advantages of a peaceful utilization of nuclear energy, and at the same time put scientists in the position to build the most terrible weapon ever, threatening mankind and earth with complete destruction. All this certainly is reason enough to recall the scientists, their work and the spirit of the time. (orig.) [de

  5. Fifty years of 'Atoms for Peace'

    International Nuclear Information System (INIS)

    Heller, W.

    2004-01-01

    Fifty years ago, on December 8, 1953, the then U.S. President, Dwight D. Eisenhower, in his famous speech before the General Assembly of the United Nations proclaimed his 'Atoms for Peace' program, which was to initiate a policy of international cooperation. The event had been preceded by a policy of the United States intended to guarantee to the United States the monopoly in the production and use of nuclear weapons, which ultimately failed because of the resistance of the Soviet Union. The doctrine of a technological monopoly in the nuclear field was to be changed in favor of cooperative ventures under the rigorous control of the United States. The 1954 Atomic Energy Act clearly formulated the will to cooperate. Following a U.S. initiative, the International Atomic Energy Agency (IAEA) was founded in 1956 to assist in transfers of nuclear technology and assume controlling functions to prevent abuse for non-peaceful purposes. Quite a number of countries used the 'Atoms for Peace' offer to develop nuclear power in very close cooperation with American industry and depending on U.S. nuclear fuel supply. On the whole, 'Atoms for Peace' has paved the way to a worldwide peaceful use of nuclear power. (orig.)

  6. The Kramers problem: Fifty years of development

    International Nuclear Information System (INIS)

    Mel'nikov, V.O.

    1990-09-01

    In the last fifty years the seminal work by Kramers of 1940 has been greatly extended both by elaboration of new theoretical approaches and through applications to new experimental systems. The most interesting case turns out to be the regime of weak-to-medium damping, in which case the Fokker-Planck equation can be reduced to an equation or to a system of integral equations of the Wiener-Hopf type. Exact solutions can then be given for the escape rate from single- and double-well potentials. This general scheme can be naturally extended to include quantum penetration through a semiclassical barrier and the effect of quantum noise. Finally, we consider the Brownian motion in a tilted washboard potential using Josephson junctions as an illustrative example. In that context we calculate (i) fluctuation-induced voltage-current characteristics, (ii) the lifetime of a zero-voltage state, (iii) the lifetime of the running state, (iv) partial probabilities of the phase jumps by 2πn (n is an integer) and (v) retrapping current distribution in both classical and quantum regimes. (author). 61 refs, 17 figs

  7. Fifty years of science, memories, and events

    CERN Multimedia

    2004-01-01

    In 2004 CERN celebrates its 50th anniversary. More precisely, on Wednesday 29 September 2004, the signature of the convention that established CERN will be 50 years old. During this special year, CERN's public web site will host a celebratory Fiftieth Anniversary web site.

  8. Fifty years of driving safety research.

    Science.gov (United States)

    Lee, John D

    2008-06-01

    This brief review covers the 50 years of driving-related research published in Human Factors, its contribution to driving safety, and emerging challenges. Many factors affect driving safety, making it difficult to assess the impact of specific factors such as driver age, cell phone distractions, or collision warnings. The author considers the research themes associated with the approximately 270 articles on driving published in Human Factors in the past 50 years. To a large extent, current and past research has explored similar themes and concepts. Many articles published in the first 25 years focused on issues such as driver impairment, individual differences, and perceptual limits. Articles published in the past 25 years address similar issues but also point toward vehicle technology that can exacerbate or mitigate the negative effect of these issues. Conceptual and computational models have played an important role in this research. Improved crash-worthiness has contributed to substantial improvements in driving safety over the past 50 years, but future improvements will depend on enhancing driver performance and perhaps, more important, improving driver behavior. Developing models to guide this research will become more challenging as new technology enters the vehicle and shifts the focus from driver performance to driver behavior. Over the past 50 years, Human Factors has accumulated a large base of driving-related research that remains relevant for many of today's design and policy concerns.

  9. Fifty years of allergy: 1965-2015.

    Science.gov (United States)

    Campbell, Dianne E; Mehr, Sam

    2015-01-01

    The last 50 years in allergy could almost be considered the first 50 years. Over this time period, we have witnessed the emergence of allergy as a subspecialty, have seen and continue to observe a tremendous change in prevalence of allergic disease and have gained insight into the mechanisms that underlie allergic predisposition and disease manifestation. We have improved the care of children with many forms of allergic disease and now sit poised to be able to alter the natural history of allergic disease with the use of specific immunotherapy. There is much left to do in the next 50 years including understanding what underlies both the predisposition to atopic disease and its natural resolution and identifying the environmental cofactors involved in the 'allergic epidemic' and therefore targets for effective primary prevention. © 2015 The Authors. Journal of Paediatrics and Child Health © 2015 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  10. Environment and Change, The Next Fifty Years.

    Science.gov (United States)

    Ewald, William R., Jr.

    As the second of three volumes published in connection with the American Institute of Planners' two-year study program, this book offers realistic goals toward which urban planning must direct itself if human society is to fulfill its need and capability for advancement. It stresses the fact that the nation can no longer afford the haphazard urban…

  11. Fifty years of atoms for peace

    International Nuclear Information System (INIS)

    Airey, P.; Tuniz, C.

    2003-01-01

    The nuclear community around the world will be marking the 50th anniversary of President Eisenhower's Atoms for Peace Speech on 8 December 2003. The Lawrence Livermore National Laboratory is organising a series of seminars in the US, Japan and France which will culminate in consensus statement Atoms for Peace after 50 Years; New Challenges and Opportunities. A separate initiative has seen the foundation of the World Nuclear University with the mission to strengthen international institutions to guide the ongoing development of the peaceful nuclear technology. The challenge for the nuclear community over the next 50 years is to redefine and recommit to the old vision in a new world challenged by new dimensions in national security, by environmental degradation and by the impacts of population pressures coupled with predicted climate change

  12. Fifty years of progress in acoustic phonetics

    Science.gov (United States)

    Stevens, Kenneth N.

    2004-10-01

    Three events that occurred 50 or 60 years ago shaped the study of acoustic phonetics, and in the following few decades these events influenced research and applications in speech disorders, speech development, speech synthesis, speech recognition, and other subareas in speech communication. These events were: (1) the source-filter theory of speech production (Chiba and Kajiyama; Fant); (2) the development of the sound spectrograph and its interpretation (Potter, Kopp, and Green; Joos); and (3) the birth of research that related distinctive features to acoustic patterns (Jakobson, Fant, and Halle). Following these events there has been systematic exploration of the articulatory, acoustic, and perceptual bases of phonological categories, and some quantification of the sources of variability in the transformation of this phonological representation of speech into its acoustic manifestations. This effort has been enhanced by studies of how children acquire language in spite of this variability and by research on speech disorders. Gaps in our knowledge of this inherent variability in speech have limited the directions of applications such as synthesis and recognition of speech, and have led to the implementation of data-driven techniques rather than theoretical principles. Some examples of advances in our knowledge, and limitations of this knowledge, are reviewed.

  13. Fifty Years of Innovation in Plastic Surgery

    Directory of Open Access Journals (Sweden)

    Richard M Kwasnicki

    2016-03-01

    Full Text Available BackgroundInnovation has molded the current landscape of plastic surgery. However, documentation of this process only exists scattered throughout the literature as individual articles. The few attempts made to profile innovation in plastic surgery have been narrative, and therefore qualitative and inherently biased. Through the implementation of a novel innovation metric, this work aims to identify and characterise the most prevalent innovations in plastic surgery over the last 50 years.MethodsPatents and publications related to plastic surgery (1960 to 2010 were retrieved from patent and MEDLINE databases, respectively. The most active patent codes were identified and grouped into technology areas, which were subsequently plotted graphically against publication data. Expert-derived technologies outside of the top performing patents areas were additionally explored.ResultsBetween 1960 and 2010, 4,651 patents and 43,118 publications related to plastic surgery were identified. The most active patent codes were grouped under reconstructive prostheses, implants, instruments, non-invasive techniques, and tissue engineering. Of these areas and other expert-derived technologies, those currently undergoing growth include surgical instruments, implants, non-invasive practices, transplantation and breast surgery. Innovations related to microvascular surgery, liposuction, tissue engineering, lasers and prostheses have all plateaued.ConclusionsThe application of a novel metric for evaluating innovation quantitatively outlines the natural history of technologies fundamental to the evolution of plastic surgery. Analysis of current innovation trends provides some insight into which technology domains are the most active.

  14. Fifty years of German nuclear legislation

    International Nuclear Information System (INIS)

    Heller, W.

    2006-01-01

    The political situation and the state of legislation after World War II make it difficult to pinpoint a precise date of origin of German nuclear legislation. The restrictions imposed by the Allied High Commission (AHC) without any exception put a ban on the production of uranium and thorium metal as well as the construction of nuclear reactors. These restrictions were lifted expressly when the German Atomic Energy Act (AtG) entered into force on January 1, 1960, i.e. much later than the formal step of gaining sovereignty, which was marked by the protocol of May 5, 1955 terminating the Occupation Statute. In October 1955, the German federal government established the then Federal Ministry for Atomic Matters also in an attempt to reconnect to developments in nuclear fission in other parts of the Western world. To supersede the AHC law, the German federal government in December 1956 publicized a draft Atomic Energy Act. It is safe, therefore, to consider that year the starting point of German atomic legislation. This step was followed by deliberations preparatory to the adoption of the Atomic Energy Act. In 1957, however, adoption failed because no two-thirds majority was reached to amend the Basic Law, i.e. the Constitution. As a consequence, some federal states saw the need to adopt state legislation to regulate this area. On December 3, 1959, a new draft Atomic Energy Act was adopted by the German federal parliament after the second and third readings - coupled with an amendment to the Basic Law on that same day - with the votes of the opposition and with one abstention. (orig.)

  15. Atoms for Peace after Fifty Years

    International Nuclear Information System (INIS)

    Joeck, N.; Lehman, R.; Vergino, E.; Schock, R.

    2004-01-01

    President Eisenhower's hopes for nuclear technology still resonate, but the challenges to fulfilling them are much different today. On December 8, 1953, President Eisenhower, returning from his meeting with the leaders of Britain and France at the Bermuda Summit, flew directly to New York to address the United Nations General Assembly. His presentation, known afterwards as the ''Atoms for Peace'' speech, was bold, broad, and visionary. Eisenhower highlighted dangers associated with the further spread of nuclear weapons and the end of the thermonuclear monopoly, but the president also pointed to opportunities. Earlier that year, Stalin had died and the Korean War armistice was signed. Talks on reunification of Austria were about to begin. The speech sought East-West engagement and outlined a framework for reducing nuclear threats to security while enhancing the civilian benefits of nuclear technology. One specific proposal offered to place surplus military fissile material under the control of an ''international atomic energy agency'' to be used for peaceful purposes, especially economic development. Eisenhower clearly recognized the complex interrelationships between different nuclear technologies and the risks and the benefits that accrue from each. The widespread use of civilian nuclear technology and absence of any use of a nuclear weapon during the next half-century reflects success in his approach. Today, the world faces choices about nuclear technology that have their parallels in the Eisenhower calculus and its legacy. Although his specific fissile material proposal was never implemented, his broader themes gave impetus to agreements such as the nuclear Non-Proliferation Treaty (NPT) and institutions such as the International Atomic Energy Agency (IAEA). The resulting governance process has promoted some and restricted other nuclear technology. Perhaps even more influential was Eisenhower's overarching recommendation that we try to reduce the risks and seek

  16. Fifty Years of Lightning Observations from Space

    Science.gov (United States)

    Christian, H. J., Jr.

    2017-12-01

    Some of the earliest satellites, starting with OSO (1965), ARIEL (1967), and RAE (1968), detected lightning using either optical and RF sensors, although that was not their intent. One of the earliest instruments designed to detect lightning was the PBE (1977). The use of space to study lightning activity has exploded since these early days. The advent of focal-plane imaging arrays made it possible to develop high performance optical lightning sensors. Prior to the use of charged-coupled devices (CCD), most space-based lightning sensors used only a few photo-diodes, which limited the location accuracy and detection efficiency (DE) of the instruments. With CCDs, one can limit the field of view of each detector (pixel), and thus improve the signal to noise ratio over single-detectors that summed the light reflected from many clouds with the lightning produced by a single cloud. This pixelization enabled daytime DE to increase from a few percent to close to 90%. The OTD (1995), and the LIS (1997), were the first lightning sensors to utilize focal-plane arrays. Together they detected global lightning activity for more than twenty years, providing the first detailed information on the distribution of global lightning and its variability. The FORTE satellite was launched shortly after LIS, and became the first dedicated satellite to simultaneously measure RF and optical lightning emissions. It too used a CCD focal plane to detect and locate lightning. In November 2016, the GLM became the first lightning instrument in geostationary orbit. Shortly thereafter, China placed its GLI in orbit. Lightning sensors in geostationary orbit significantly increase the value of space-based observations. For the first time, lightning activity can be monitored continuously, over large areas of the Earth with high, uniform DE and location accuracy. In addition to observing standard lightning, a number of sensors have been placed in orbit to detect transient luminous events and

  17. Fifty years of Jaynes-Cummings physics

    Science.gov (United States)

    Greentree, Andrew D.; Koch, Jens; Larson, Jonas

    2013-11-01

    electromagnetic modes, arrays of coupled cavities [5-7], and optomechanical systems [8] have further enriched the physics of the Jaynes-Cummings model. From the early interests in masers and the consistent quantum description of radiation and atom-photon interaction, the Jaynes-Cummings model has evolved into a cornerstone of quantum state engineering [9]. The authors of this editorial had not been born when Jaynes and Cummings wrote their remarkable paper. It is, therefore, a special honour for us to be able to draw the reader's attention to the accompanying reminiscence contributed by Frederick Cummings where he gives us a glimpse of the early history of the Jaynes-Cummings model from his perspective [11]. By now, the original 1963 paper by Jaynes and Cummings has gathered numerous citations and, at the time of writing, the number of articles involving Jaynes-Cummings physics is approaching 15 000.1 This special issue does not attempt to review this impressive wealth of research. The interested reader, however, is urged to consult the definitive article by Shore and Knight [10] for a comprehensive review of the first 30 years of Jaynes-Cummings physics. The collection of 26 papers presented in this issue, showcases a snapshot of some of the most recent and continuing research devoted to Jaynes-Cummings physics. We begin our special issue with Professor Cumming's recollections [11]. We then have six papers on quantum information aspects of the Jaynes-Cummings model [12-17]. The next topic includes seven papers on the Dicke and generalized Jaynes-Cummings models [18-24], followed by six papers on circuit QED, which is one of the most important experimental frameworks for Jaynes-Cummings systems [25-30]. Finally, we have six papers on the extension to many cavities, the Jaynes-Cummings-Hubbard model [31-36]. The snapshot of research captured in this special issue illustrates the unifying language provided by the Jaynes-Cummings model, tying together research in a number of

  18. EDITORIAL: Semiconductor lasers: the first fifty years Semiconductor lasers: the first fifty years

    Science.gov (United States)

    Calvez, S.; Adams, M. J.

    2012-09-01

    Anniversaries call for celebrations. Since it is now fifty years since the first semiconductor lasers were reported, it is highly appropriate to celebrate this anniversary with a Special Issue dedicated to the topic. The semiconductor laser now has a major effect on our daily lives since it has been a key enabler in the development of optical fibre communications (and hence the internet and e-mail), optical storage (CDs, DVDs, etc) and barcode scanners. In the early 1960s it was impossible for most people (with the exception of very few visionaries) to foresee any of these future developments, and the first applications identified were for military purposes (range-finders, target markers, etc). Of course, many of the subsequent laser applications were made possible by developments in semiconductor materials, in the associated growth and fabrication technology, and in the increased understanding of the underlying fundamental physics. These developments continue today, so that the subject of semiconductor lasers, although mature, is in good health and continues to grow. Hence, we can be confident that the pervasive influence of semiconductor lasers will continue to develop as optoelectronics technology makes further advances into other sectors such as healthcare, security and a whole host of applications based on the global imperatives to reduce energy consumption, minimise environmental impact and conserve resources. The papers in this Special Issue are intended to tell some of the story of the last fifty years of laser development as well as to provide evidence of the current state of semiconductor laser research. Hence, there are a number of papers where the early developments are recalled by authors who played prominent parts in the story, followed by a selection of papers from authors who are active in today's exciting research. The twenty-fifth anniversary of the semiconductor laser was celebrated by the publication of a number of papers dealing with the early

  19. Fifty years of Cuba's medical diplomacy: from idealism to pragmatism.

    Science.gov (United States)

    Feinsilver, Julie M

    2010-01-01

    Medical diplomacy, the collaboration between countries to simultaneously produce health benefits and improve relations, has been a cornerstone of Cuban foreign policy since the outset of the revolution fifty years ago. It has helped Cuba garner symbolic capital (goodwill, influence, and prestige) well beyond what would have been possible for a small, developing country, and it has contributed to making Cuba a player on the world stage. In recent years, medical diplomacy has been instrumental in providing considerable material capital (aid, credit, and trade), as the oil-for-doctors deals with Venezuela demonstrates. This has helped keep the revolution afloat in trying economic times. What began as the implementation of the one of the core values of the revolution, namely health as a basic human right for all peoples, has continued as both an idealistic and a pragmatic pursuit. This article examines the factors that enabled Cuba to conduct medical diplomacy over the past fifty years, the rationale behind the conduct of this type of soft power politics, the results of that effort, and the mix of idealism and pragmatism that has characterized the experience. Moreover, it presents a typology of medical diplomacy that Cuba has used over the past fifty years.

  20. Nuclear spin: Fifty years of ups and downs

    Energy Technology Data Exchange (ETDEWEB)

    Pines, A. [Lawrence Berkeley National Lab., CA (United States)

    1996-12-31

    Rumors of its demise notwithstanding, nuclear magnetic resonance (NMR) continues to flourish fifty years after our birth. The lecture will be a reminiscence about moments of excitation, coherence and relaxation in the history of NMR which produced, among other developments, spin echoes and time reversal, Fourier transform and multidimensional spectroscopy, magnetic resonance imaging, and high resolution solid state NMR. Applications of modern NMR spectroscopy cut across the boundaries of physics, chemistry, materials, biology and medicine.

  1. Fifty years of sociological leadership at Social Science and Medicine.

    Science.gov (United States)

    Timmermans, Stefan; Tietbohl, Caroline

    2018-01-01

    In this review article, we examine some of the conceptual contributions of sociology of health and illness over the past fifty years. Specifically, we focus on research dealing with medicalization, the management of stigma, research on adherence and compliance, and patient-doctor interaction. We show how these themes that originated within sociology, diffused in other disciplines. Sociology in Social Science and Medicine started as an applied research tradition but morphed into a robust, stand-alone social science tradition. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Fifty years in fusion and the way forward

    International Nuclear Information System (INIS)

    Jacquinot, J.

    2010-01-01

    This particular 'Fusion Pioneers Memorial lecture' was given 50 years after the first historical FEC conference in 1958. It was a unique occasion to perform a global reflection on thermonuclear fusion which is summarized in this paper. We first consider the case for fusion energy then move on to the scientific achievements during the past five decades. Finally, the lessons drawn from the past give a framework to consider the challenges ahead of us. The 1958 pioneers had the vision of the vital importance of international collaboration to succeed in this unique endeavour. Fifty years later, this vision has amply proven its worth. Looking at the way forward, this vision constitutes a strong basis to harness fusion energy in the decades to come.

  3. Fifty years of mathematical physics selected works of Ludwig Faddeev

    CERN Document Server

    Faddeev, Ludwig; Niemi, Antti J

    2016-01-01

    This unique volume summarizes with a historical perspective several of the major scientific achievements of Ludwig Faddeev, with a foreword by Nobel Laureate C N Yang. The volume that spans over fifty years of Faddeev's career begins where he started his own scientific research, in the subject of scattering theory and the three-body problem. It then continues to describe Faddeev's contributions to automorphic functions, followed by an extensive account of his many fundamental contributions to quantum field theory including his original article on ghosts with Popov. Faddeev's contributions to soliton theory and integrable models are then described, followed by a survey of his work on quantum groups. The final scientific section is devoted to Faddeev's contemporary research including articles on his long-term interest in constructing knotted solitons and understanding confinement. The volume concludes with his personal view on science and mathematical physics in particular.

  4. The fifty-year-old woman and midlife stress.

    Science.gov (United States)

    Campbell, S

    It has been assumed that the fifties are a relatively stable decade; however, women in their fifties are susceptible to many stresses, internal and external. The possibilities of widowhood, divorce, or poverty, combined with intra- and interpersonal strains, make this a time of insecurity about aging for many women. Some suggestions as to why women nonetheless cope successfully with aging are considered.

  5. The anomaly of Marquesan ceramics : a fifty year retrospective

    International Nuclear Information System (INIS)

    Allen, M.S.; Dickinson, W.R.; Huebert, J.M.

    2012-01-01

    Fifty years ago pioneering archaeologist Robert Suggs reported a small number of pottery sherds from the Marquesas Islands. The first such finds in East Polynesia, at the time they were considered indicative of both a Marquesan homeland and local ceramic manufacture. In the intervening years, additional sherds have been recovered from three other Marquesan localities resulting in a total of 14 specimens. Prior petrographic studies demonstrate unambiguously that some derive from Fiji. Others have been interpreted historically as representative of an indigenous Marquesan ceramic industry. Here we bring together key petrographic analyses from Polynesia, recent chronological assessments of the Marquesan sequence, and insights from new field research to reassess the origins and chronology of Marquesan pottery. We suggest that there is little support for an indigenous Marquesan ceramic industry, and most likely all of the specimens are imports. With respect to the timing of ceramic arrivals, three hypotheses are explored: 1) with founding settlers, 2) as a component of long-distance exchange networks operating between the 12th to 16th centuries AD, or 3) as late prehistoric or historic imports. The preponderance of evidence points to the second alternative, although the other two cannot be completely discounted for the assemblage as a whole. (author). 63 refs., 5 figs., 3 tabs.

  6. The Proton Synchrotron, going strong at fifty years

    CERN Multimedia

    Django Manglunki

    It was on the evening of 24 November 1959 that an incredulous Hildred Blewett, on detachment to CERN from the Brookhaven laboratory, exclaimed “Yes! We’re through transition!” The first beam of ten billion protons had not only broken through the 5.2 GeV barrier but gone on all the way to 24 GeV, the machine’s top energy at that time.   An operational screenshot from the PS, taken on its 50th anniversary. The three white peaks depict different phases (cycles) of the PS’s operation. In the first and third cycle, the PS is producing a very low-intensity beam for LHC commissioning. In the second cycle, protons are being spilled out for use in the East Area. Fifty years ago the PS, the first strong-focusing proton synchrotron using alternating gradient technology, first began to circulate beams at an unprecedented level of energy. Over the years, a complex of linear and circular accelerators and storage rings grew up around the PS. In the mid-1990s ...

  7. Fifty years of hemodialysis access literature: The fifty most cited publications in the medical literature.

    Science.gov (United States)

    Skripochnik, Edvard; O'Connor, David J; Trestman, Eric B; Lipsitz, Evan C; Scher, Larry A

    2018-02-01

    Objectives The modern era of hemodialysis access surgery began with the publication in 1966 by Brescia et al. describing the use of a surgically created arteriovenous fistula. Since then, the number of patients on chronic hemodialysis and the number of publications dealing with hemodialysis access have steadily increased. We have chronicled the increase in publications in the medical literature dealing with hemodialysis access by evaluating the characteristics of the 50 most cited articles. Methods We queried the Science Citation Index from the years 1960-2014. Articles were selected based on a subject search and were ranked according to the number of times they were cited in the medical literature. Results The 50 most frequently cited articles were selected for further analysis and the number of annual publications was tracked. The landmark publication by Dr Brescia et al. was unequivocally the most cited article dealing with hemodialysis access (1109 citations). The subject matter of the papers included AV fistula and graft (9), hemodialysis catheter (9), complications and outcomes (24), and other topics (8). Most articles were published in nephrology journals (33), with fewer in surgery (7), medicine (7), and radiology (3) journals. Of the 17 journals represented, Kidney International was the clear leader, publishing 18 articles. There has been an exponential rise in the frequency of publications regarding dialysis access with 42 of 50 analyzed papers being authored after 1990. Conclusion As the number of patients on hemodialysis has increased dramatically over the past five decades, there has been a commensurate increase in the overall number of publications related to hemodialysis access.

  8. Fifty years of fuzzy logic and its applications

    CERN Document Server

    Rishe, Naphtali; Kandel, Abraham

    2015-01-01

    This book presents a comprehensive report on the evolution of Fuzzy Logic since its formulation in Lotfi Zadeh’s seminal paper on “fuzzy sets,” published in 1965. In addition, it features a stimulating sampling from the broad field of research and development inspired by Zadeh’s paper. The chapters, written by pioneers and prominent scholars in the field, show how fuzzy sets have been successfully applied to artificial intelligence, control theory, inference, and reasoning. The book also reports on theoretical issues; features recent applications of Fuzzy Logic in the fields of neural networks, clustering, data mining, and software testing; and highlights an important paradigm shift caused by Fuzzy Logic in the area of uncertainty management. Conceived by the editors as an academic celebration of the fifty years’ anniversary of the 1965 paper, this work is a must-have for students and researchers willing to get an inspiring picture of the potentialities, limitations, achievements and accomplishments...

  9. Anniversary Paper: Nuclear medicine: Fifty years and still counting

    International Nuclear Information System (INIS)

    Williams, Lawrence E.

    2008-01-01

    The history, present status, and possible future of nuclear medicine are presented. Beginning with development of the rectilinear scanner and gamma camera, evolution to the present forms of hybrid technology such as single photon emission computed tomography/computed tomography (CT) and positron emission tomography/CT is described. Both imaging and therapy are considered and the recent improvements in dose estimation using hybrid technologies are discussed. Future developments listed include novel radiopharmaceuticals created using short chains of nucleic acids and varieties of nanostructures. Patient-specific radiotherapy is an eventual outcome of this work. Possible application to proving the targeting of potential chemotherapeutics is also indicated

  10. Student Interviews Fifty Years Later: An Oral History

    OpenAIRE

    2018-01-01

    The Regional History Project at UC Santa Cruz has rich collections of interviews with generations of narrators, ranging across the administration, faculty, and staff. In the early years of the campus, founding director Elizabeth Spedding Calciano conducted two rounds of interviews focused on the student experience at what was then the newest campus of the University of California. Those interviews, conducted in 1967 and 1969 as the campus was still adding a new college every year, give a wind...

  11. Fifty years of CERN history in the spotlight

    CERN Document Server

    2004-01-01

    The programme of events for CERN's Golden Jubilee year was officially unveiled at a press conference on 8 March. The first of these events took place the following day, when the Swiss commemorative postage stamp issued in the Laboratory's honour went on sale in post offices throughout Switzerland.

  12. Fifty years of invasion ecology: The legacy of Charles Elton

    Czech Academy of Sciences Publication Activity Database

    Richardson, D. M.; Pyšek, Petr

    2008-01-01

    Roč. 14, č. 2 (2008), s. 161-168 ISSN 1366-9516 R&D Projects: GA MŠk(CZ) LC06073 Institutional research plan: CEZ:AV0Z60050516 Keywords : bibliometric analysis * biological invasions * citation analysis Subject RIV: EF - Botanics Impact factor: 3.446, year: 2008

  13. Fifty years of Tsetse control in Tanzania: challenges and prospects ...

    African Journals Online (AJOL)

    Even after 50 years of independence, Human African Trypanosomiasis (HAT) or Sleeping Sickness is still one of the major public health problems with about 300 cases being reported annually. Tsetse control has been sporadic and uncoordinated hence no tangible results have been accrued since independence despite ...

  14. Fifty Years of Boundary-Layer Theory and Experiment

    Science.gov (United States)

    Dryden, Hugh L.

    1955-01-01

    The year 1954 marked the 50th anniversary of the Prandtl boundary-layer theory from which we may date the beginning of man's understanding of the dynamics of real fluids. A backward look at this aspect of the history of the last 50 years may be instructive. This paper (1) attempts to compress the events of those 50 years into a few thousand words, to tell in this brief space the interesting story of the development of a new concept, its slow acceptance and growth, its spread from group to group within its country of origin, and its diffusion to other countries of the world. The original brief paper of Prandtl (2) was presented at the Third International Mathematical Congress at Heidelberg in 1904 and published in the following year. It was an attempt to explain the d'Alembert paradox, namely, that the neglect of the small friction of air in the theory resulted in the prediction of zero resistance to motion. Prandtl set himself the task of computing the motion of a fluid of small friction, so small that its effect could be neglected everywhere except where large velocity differences were present or a cumulative effect of friction occurred This led to the concept of boundary layer, or transition layer, near the wall of a body immersed in a fluid stream in which the velocity rises from zero to the free-stream value. It is interesting that Prandtl used the term Grenzsehicht (boundary layer) only once and the term Ubergangsschicht (transition layer) seven times in the brief article. Later writers also used Reibungsschicht (friction layer), but most writers today use Grenzschicht (boundary layer).

  15. Bibliometric analysis of fifty years of physica status solidi

    Energy Technology Data Exchange (ETDEWEB)

    Marx, Werner [Max Planck Institute for Solid State Research, Stuttgart (Germany); Hoffmann, Dieter [Max Planck Institute for the History of Sciences, Berlin (Germany)

    2011-12-15

    Bibliometric methods are used to analyze quantitatively the journal physica status solidi (pss) 50 years after its inception. First, the coverage of the journal by the relevant citation indices accessible under the Web of Science (WoS) and the field-specific INSPEC database is examined. The number of papers published per year by the journal as a whole and by the specific pss series is given. The time evolution of the pss output in terms of papers per year is compared with the output evolution of some major competing journals in the field of condensed-matter physics. The top-12 most frequently cited pss papers published within the complete time period 1961-2010 and within the two separate time periods 1974-1989 and 1990-2010 (before and after the German reunification) are listed. The citation time curves (citation history) of the three most frequently cited pss papers are presented. Furthermore, the Journal Impact Factors (JIFs) of the pss journal series (a) and (b) are discussed and their time evolution is shown. Moreover, the distribution of the pss papers over their document types and the authors is given. The countries of authors are ranked for the complete time period 1961-2010 as well as for the time periods 1973-1989 and 1990-2010. The complete ensemble of the citing papers of the pss papers is analyzed and discussed. The journals citing most often the pss papers published in the year 2000 are listed. Finally, the distribution of the pss papers over the various subject areas and classification terms based on the INSPEC database is tabled. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. DMPD: Fifty years of interferon research: aiming at a moving target. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available mmunity. 2006 Sep;25(3):343-8. (.png) (.svg) (.html) (.csml) Show Fifty years of interferon research: aiming at a moving target. Pubm...edID 16979566 Title Fifty years of interferon research: aiming at a moving target.

  17. Fifty years of IAA History Symposia (1967-2016)

    Science.gov (United States)

    Skoog, A. Ingemar; Hall, R. Cargill

    2017-05-01

    The International Academy of Astronautics (IAA) Symposia on the History of Rocketry and Astronautics have been held annually at the International Astronautical Congresses since 1967. During these past 50 years nearly 800 papers have been presented and subsequently published in the proceedings. With a 20-year rule imposed for historical presentations, the first 10 symposia concentrated on pre-World War II and early 1950s activities. A surprisingly large number of papers on early, less well-known Soviet-Russian contributions to rocketry and astronautics were presented in the first symposia, despite the ongoing Space Race between the U.S and USSR. Another important element in these symposia involved memoir papers offered by pre- and post-war rocket and astronautics pioneers from many countries, and the participation of many of these pioneers in person. In sum, the history of national space and rocket projects from some 40 countries were presented over the years in IAA History Symposia. These 50 symposia have provided a platform for scholars and professional and non-professional historians to meet and discuss the history of rocketry and astronautics, and to personally interview many space pioneers, most of whom today are deceased. Their personal recollections have since been shared with a large audience. Over time, IAA history papers divided into recognizable periods: ancient times through the 19th century, and the 20th and 21st centuries, which separate among actions and events that took place before 1945, in 1945 to 1957, and after 1957 (which marked the beginning of the space age). Proceedings of the IAA History Symposia have been published in English, ultimately in the History Series of the American Astronautical Society (AAS) and its publishing arm, Univelt Inc., under an agreement secured with the IAA. This paper presents an overview of the IAA History Symposia. It examines the early years of the history committee and its first symposium, the evolution of

  18. Fifty years of fuel quality and vehicle emissions

    Energy Technology Data Exchange (ETDEWEB)

    Rose, K. [CONCAWE, Brussels (Belgium)

    2013-04-01

    In the late 1970s, with growing emphasis on urban air quality in Europe, CONCAWE embarked on new research related to fuels and vehicles. After only a few years, it became clear that fuel properties and specifications would be increasingly important to the future of the European refining industry, and considerable research was completed in the 1970s to better understand the impact of fuel composition on vehicle performance and emissions. This early work led to the formation of the first Fuels and Emissions Management Group (FEMG) in 1982, almost 20 years after the formation of the CONCAWE Association. Since these early days, FEMG has been responsible for ensuring CONCAWE's strategic outlook on future vehicle and fuel developments, monitoring regulatory and vehicle developments, and overseeing a diverse portfolio of fuel quality and vehicle emissions research. Since the 1980s, tremendous progress has been made in improving European air quality, in part by reducing emissions from road transport and other sectors, and major improvements in European fuel qualities have contributed to these reductions. Nevertheless, many challenges are still ahead, especially further reductions in pollutant emissions from vehicles while also reducing greenhouse gas (GHG) emissions from transport. In the near-term, these GHG reductions will largely come from improvements in engine and vehicle fuel consumption and by blending of GHG-reducing bio-blending components. Dealing with these challenges to fuel quality and performance will require a continuing focus on CONCAWE's founding principles: sound science, cost effectiveness and transparency.

  19. Perspectives on Erving Goffman's "Asylums" fifty years on.

    Science.gov (United States)

    Adlam, John; Gill, Irwin; Glackin, Shane N; Kelly, Brendan D; Scanlon, Christopher; Mac Suibhne, Seamus

    2013-08-01

    Erving Goffman's "Asylums" is a key text in the development of contemporary, community-orientated mental health practice. It has survived as a trenchant critique of the asylum as total institution, and its publication in 1961 in book form marked a further stage in the discrediting of the asylum model of mental health care. In this paper, some responses from a range of disciplines to this text, 50 years on, are presented. A consultant psychiatrist with a special interest in cultural psychiatry and mental health legislation, two collaborating psychotherapists in adult and forensic mental health, a philosopher, and a recent medical graduate, present their varying responses to the text. The editors present these with the hope of encouraging further dialogue and debate from service users, carers, clinicians, and academics and researchers across a range of disciplines.

  20. Changes in sunflower breeding over the last fifty years

    Directory of Open Access Journals (Sweden)

    Vear Felicity

    2016-03-01

    Full Text Available This article discusses changes in sunflower breeding objectives since the introduction of hybrid varieties 50 years ago. After a reminder of the importance of some early programmes, Canadian in particular, the present situation for each breeding objective is compared with those encountered earlier. Breeding for yield has changed from maximum possible yield under intensive agriculture to yield with resistance to abiotic stresses, moderate droughts and shallow soils in particular, helped by collaboration with agronomists to produce crop models. Breeding for oil has changed from quantity to quality and the value of seed meal is again becoming economically important. Necessary disease resistances vary with agronomic practises and selection pressure on pathogens according to varietal genetics. The possibilities of new types of sunflower are also discussed. Advances in genomics will change breeding procedures, but with rapidly changing molecular techniques, international collaboration is particularly important.

  1. FIFTY YEARS OF MELPHALAN USE IN HEMATOPOIETIC STEM CELL TRANSPLANTATION

    Science.gov (United States)

    Bayraktar, Ulas D.; Bashir, Qaiser; Qazilbash, Muzaffar; Champlin, Richard E.; Ciurea, Stefan O.

    2015-01-01

    Melphalan remains the most widely used agent in preparative regimens for hematopoietic stem-cell transplantation. From its initial discovery more than 50 years ago, it has been gradually incorporated in the conditioning regimens for both autologous and allogeneic transplantation due to its myeloablative properties and broad antitumor effects as a DNA alkylating agent. Melphalan remains the mainstay conditioning for multiple myeloma and lymphomas; and has been used successfully in preparative regimens of a variety of other hematological and non-hematological malignancies. The addition of newer agents to conditioning like bortezomib or lenalidomide for myeloma, or clofarabine for myeloid malignancies, may improve antitumor effects for transplantation, while in combination with alemtuzumab may represent a backbone for future cellular therapy due to reliable engraftment and low toxicity profile. This review summarizes the development and the current use of this remarkable drug in hematopoietic stem-cell transplantation. PMID:22922522

  2. Fifty years of federal radioactive waste management: Policies and practices

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, R.G.

    1997-04-01

    This report provides a chronological history of policies and practices relating to the management of radioactive waste for which the US Atomic Energy Commission and its successor agencies, the Energy Research and Development Administration and the Department of Energy, have been responsible since the enactment of the Atomic Energy Act in 1946. The defense programs and capabilities that the Commission inherited in 1947 are briefly described. The Commission undertook a dramatic expansion nationwide of its physical facilities and program capabilities over the five years beginning in 1947. While the nuclear defense activities continued to be a major portion of the Atomic Energy Commission`s program, there was added in 1955 the Atoms for Peace program that spawned a multiplicity of peaceful use applications for nuclear energy, e.g., the civilian nuclear power program and its associated nuclear fuel cycle; a variety of industrial applications; and medical research, diagnostic, and therapeutic applications. All of these nuclear programs and activities generated large volumes of radioactive waste that had to be managed in a manner that was safe for the workers, the public, and the environment. The management of these materials, which varied significantly in their physical, chemical, and radiological characteristics, involved to varying degrees the following phases of the waste management system life cycle: waste characterization, storage, treatment, and disposal, with appropriate transportation linkages. One of the benefits of reviewing the history of the waste management program policies and practices if the opportunity it provides for identifying the lessons learned over the years. Examples are summarized at the end of the report and are listed in no particular order of importance.

  3. Fifty years of federal radioactive waste management: Policies and practices

    International Nuclear Information System (INIS)

    Bradley, R.G.

    1997-04-01

    This report provides a chronological history of policies and practices relating to the management of radioactive waste for which the US Atomic Energy Commission and its successor agencies, the Energy Research and Development Administration and the Department of Energy, have been responsible since the enactment of the Atomic Energy Act in 1946. The defense programs and capabilities that the Commission inherited in 1947 are briefly described. The Commission undertook a dramatic expansion nationwide of its physical facilities and program capabilities over the five years beginning in 1947. While the nuclear defense activities continued to be a major portion of the Atomic Energy Commission's program, there was added in 1955 the Atoms for Peace program that spawned a multiplicity of peaceful use applications for nuclear energy, e.g., the civilian nuclear power program and its associated nuclear fuel cycle; a variety of industrial applications; and medical research, diagnostic, and therapeutic applications. All of these nuclear programs and activities generated large volumes of radioactive waste that had to be managed in a manner that was safe for the workers, the public, and the environment. The management of these materials, which varied significantly in their physical, chemical, and radiological characteristics, involved to varying degrees the following phases of the waste management system life cycle: waste characterization, storage, treatment, and disposal, with appropriate transportation linkages. One of the benefits of reviewing the history of the waste management program policies and practices if the opportunity it provides for identifying the lessons learned over the years. Examples are summarized at the end of the report and are listed in no particular order of importance

  4. Fifty years of progress in speech coding standards

    Science.gov (United States)

    Cox, Richard

    2004-10-01

    Over the past 50 years, speech coding has taken root worldwide. Early applications were for the military and transmission for telephone networks. The military gave equal priority to intelligibility and low bit rate. The telephone network gave priority to high quality and low delay. These illustrate three of the four areas in which requirements must be set for any speech coder application: bit rate, quality, delay, and complexity. While the military could afford relatively expensive terminal equipment for secure communications, the telephone network needed low cost for massive deployment in switches and transmission equipment worldwide. Today speech coders are at the heart of the wireless phones and telephone answering systems we use every day. In addition to the technology and technical invention that has occurred, standards make it possible for all these different systems to interoperate. The primary areas of standardization are the public switched telephone network, wireless telephony, and secure telephony for government and military applications. With the advent of IP telephony there are additional standardization efforts and challenges. In this talk the progress in all areas is reviewed as well as a reflection on Jim Flanagan's impact on this field during the past half century.

  5. Fifty years of atomic time-keeping at VNIIFTRI

    International Nuclear Information System (INIS)

    Domnin, Y.; Gaigerov, B.; Koshelyaevsky, N.; Poushkin, S.; Rusin, F.; Tatarenkov, V.; Yolkin, G.

    2005-01-01

    Time metrology in Russia in the second half of the twentieth century has been marked, as in other advanced countries, by the rapid development of time and frequency quantum standards and the beginning of atomic time-keeping. This brief review presents the main developments and studies in time and frequency measurement, and the improvement of accuracy and atomic time-keeping at the VNIIFTRI-the National Metrology Institute keeping primary time and frequency standards and ensuring unification of measurement. The milestones along the way have been the ammonia and hydrogen masers, primary caesium beam and fountain standards and laser frequency standards. For many years, VNIIFTRI was the only world laboratory that applied hydrogen-maser clock ensembles for time-keeping. VNIIFTRI's work on international laser standard frequency comparisons and absolute frequency measurements contributed greatly to the adoption by the CIPM of a highly accurate value for the He-Ne/CH 4 laser frequency. VNIIFTRI and the VNIIM were the first to establish a united time, frequency and length standard. (authors)

  6. Fifty years of atomic time-keeping at VNIIFTRI

    Energy Technology Data Exchange (ETDEWEB)

    Domnin, Y.; Gaigerov, B.; Koshelyaevsky, N.; Poushkin, S.; Rusin, F.; Tatarenkov, V.; Yolkin, G. [VNIIFTRI (Russian Federation)

    2005-06-01

    Time metrology in Russia in the second half of the twentieth century has been marked, as in other advanced countries, by the rapid development of time and frequency quantum standards and the beginning of atomic time-keeping. This brief review presents the main developments and studies in time and frequency measurement, and the improvement of accuracy and atomic time-keeping at the VNIIFTRI-the National Metrology Institute keeping primary time and frequency standards and ensuring unification of measurement. The milestones along the way have been the ammonia and hydrogen masers, primary caesium beam and fountain standards and laser frequency standards. For many years, VNIIFTRI was the only world laboratory that applied hydrogen-maser clock ensembles for time-keeping. VNIIFTRI's work on international laser standard frequency comparisons and absolute frequency measurements contributed greatly to the adoption by the CIPM of a highly accurate value for the He-Ne/CH{sub 4} laser frequency. VNIIFTRI and the VNIIM were the first to establish a united time, frequency and length standard. (authors)

  7. Fifty years of atomic time-keeping at VNIIFTRI

    Science.gov (United States)

    Domnin, Yu; Gaigerov, B.; Koshelyaevsky, N.; Poushkin, S.; Rusin, F.; Tatarenkov, V.; Yolkin, G.

    2005-06-01

    Time metrology in Russia in the second half of the twentieth century has been marked, as in other advanced countries, by the rapid development of time and frequency quantum standards and the beginning of atomic time-keeping. This brief review presents the main developments and studies in time and frequency measurement, and the improvement of accuracy and atomic time-keeping at the VNIIFTRI—the National Metrology Institute keeping primary time and frequency standards and ensuring unification of measurement. The milestones along the way have been the ammonia and hydrogen masers, primary caesium beam and fountain standards and laser frequency standards. For many years, VNIIFTRI was the only world laboratory that applied hydrogen-maser clock ensembles for time-keeping. VNIIFTRI's work on international laser standard frequency comparisons and absolute frequency measurements contributed greatly to the adoption by the CIPM of a highly accurate value for the He-Ne/CH4 laser frequency. VNIIFTRI and the VNIIM were the first to establish a united time, frequency and length standard.

  8. Nuclear chemistry fifty years after the discovery of artificial radioactivity

    International Nuclear Information System (INIS)

    Lefort, M.

    1984-01-01

    In January 1934, the observation and the chemical identification of radiophosphorus as a reaction product in the bombardment of Aluminium by alpha particles have been the first step of a new scientific branch: Nuclear Chemistry. We describe here how this discovery in itself contains the frame of all the development which has followed. It consisted in four stages, each of them being a crucial starting point. The first one is the possibility for a total balance of the nuclear reaction in the exit channels, so that reaction mechanisms can be studied. The second, the most important perhaps, is the opening of nuclear synthesis. Nuclear chemists can now interfere into nuclear matter and instead of staying as observers of the radioactive decays of natural isotopes, they were able to build up a numerous chart of various nuclear species, going step by step further and further away from the nuclear stability conditions. The third aspect of the discovery was the appearance of a new mode of radioactive decay with the production of the first particle an antimater. 50 years later, the instability due to a much larger excess of protons is known to induce the proton emission radioactivity for new species like 109 I or 115 Cs, in the vicinity of proton unstability. Finally, the last point, so fertile for the future, was the observation of a neutron in the exit channel, so that neutron fluxes could result from alpha induced nuclear reactions and became such a strong tool for the production of transuranium elements and for nuclear fission. In the present survey, the wide interest of the second point, i.e. the nuclear synthesis, is emphasized, as well as the huge change in the technical methods

  9. Fifty Years of Water Sensitive Urban Design, Salisbury, South Australia

    Institute of Scientific and Technical Information of China (English)

    John C.Radcliffe; Declan Page; Bruce Naumann; Peter Dillon

    2017-01-01

    Australia has developed extensive policies and guidelines for the management of its water.The City of Salisbury,located within metropolitan Adelaide,South Australia,developed rapidly through urbanisation from the 1970s.Water sensitive urban design principles were adopted to maximise the use of the increased run-off generated by urbanisation and ameliorate flood risk.Managed aquifer recharge was introduced for storing remediated low-salinity stormwater by aquifer storage and recovery (ASR) in a brackish aquifer for subsequent irrigation.This paper outlines how a municipal government has progressively adopted principles of Water Sensitive Urban Design during its development within a framework of evolving national water policies.Salisbury's success with stormwater harvesting led to the formation of a pioneering water business that includes linking projects from nine sites to provide a non-potable supply of 5 × 106 m3 ·year-1.These installations hosted a number of applied research projects addressing well configuration,water quality,reliability and economics and facilitated the evaluation of its system as a potential potable water source.The evaluation showed that while untreated stormwater contained contaminants,subsurface storage and end-use controls were sufficient to make recovered water safe for public open space irrigation,and with chlorination,acceptable for third pipe supplies.Drinking water quality could be achieved by adding microfiltration,disinfection with UV and chlorination.The costs that would need to be expended to achieve drinking water safety standards were found to be considerably less than the cost of establishing dual pipe distribution systems.The full cost of supply was determined to be AUD$1.57 m-3 for non-potable water for public open space irrigation,much cheaper than mains water,AUD $3.45 m-3 at that time.Producing and storing potable water was found to cost AUD$1.96 to $2.24 m-3.

  10. Fifty Years of THERP and Human Reliability Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ronald L. Boring

    2012-06-01

    In 1962 at a Human Factors Society symposium, Alan Swain presented a paper introducing a Technique for Human Error Rate Prediction (THERP). This was followed in 1963 by a Sandia Laboratories monograph outlining basic human error quantification using THERP and, in 1964, by a special journal edition of Human Factors on quantification of human performance. Throughout the 1960s, Swain and his colleagues focused on collecting human performance data for the Sandia Human Error Rate Bank (SHERB), primarily in connection with supporting the reliability of nuclear weapons assembly in the US. In 1969, Swain met with Jens Rasmussen of Risø National Laboratory and discussed the applicability of THERP to nuclear power applications. By 1975, in WASH-1400, Swain had articulated the use of THERP for nuclear power applications, and the approach was finalized in the watershed publication of the NUREG/CR-1278 in 1983. THERP is now 50 years old, and remains the most well known and most widely used HRA method. In this paper, the author discusses the history of THERP, based on published reports and personal communication and interviews with Swain. The author also outlines the significance of THERP. The foundations of human reliability analysis are found in THERP: human failure events, task analysis, performance shaping factors, human error probabilities, dependence, event trees, recovery, and pre- and post-initiating events were all introduced in THERP. While THERP is not without its detractors, and it is showing signs of its age in the face of newer technological applications, the longevity of THERP is a testament of its tremendous significance. THERP started the field of human reliability analysis. This paper concludes with a discussion of THERP in the context of newer methods, which can be seen as extensions of or departures from Swain’s pioneering work.

  11. Serving the Nation for Fifty Years: 1952 - 2002 Lawrence Livermore National Laboratory [LLNL], Fifty Years of Accomplishments

    Science.gov (United States)

    2002-01-01

    For 50 years, Lawrence Livermore National Laboratory has been making history and making a difference. The outstanding efforts by a dedicated work force have led to many remarkable accomplishments. Creative individuals and interdisciplinary teams at the Laboratory have sought breakthrough advances to strengthen national security and to help meet other enduring national needs. The Laboratory's rich history includes many interwoven stories -- from the first nuclear test failure to accomplishments meeting today's challenges. Many stories are tied to Livermore's national security mission, which has evolved to include ensuring the safety, security, and reliability of the nation's nuclear weapons without conducting nuclear tests and preventing the proliferation and use of weapons of mass destruction. Throughout its history and in its wide range of research activities, Livermore has achieved breakthroughs in applied and basic science, remarkable feats of engineering, and extraordinary advances in experimental and computational capabilities. From the many stories to tell, one has been selected for each year of the Laboratory's history. Together, these stories give a sense of the Laboratory -- its lasting focus on important missions, dedication to scientific and technical excellence, and drive to made the world more secure and a better place to live.

  12. Laser applications for energy. Fifty years since advent of laser and next thirty years

    International Nuclear Information System (INIS)

    Nakai, Sadao

    2011-01-01

    The utilization of light has been changed since the advent of lasers about fifty years ago. Now in the twenty first century, laser science is being applied in every industry as the fundamental technology. In the recent years, remarkable progresses have been made in the semiconductor lasers of high power and wide wavelength region. The amazing developments of ceramics laser materials like YAG and nonlinear optics materials of organic crystals have been achieved as well as the big progress in the fiber lasers. It is also to be pointed out that very high power ultra short laser pulses have become available. In the field of power photonics, which is based on the power semiconductor lasers, fiber lasers and new laser materials, various industrial applications are expected to be constructed further in civil engineering, manufacturing technology, agricultural and biological applications, medical utilization and space sciences. It is expected, by the development of ultra short pulse and ultra high mean power lasers, that particle accelerations, ultra high density sciences, nuclear fusion neutron sources and laser fusion power reactors are to be advanced drastically. Recent development and future prospects of high power lasers are illustrated. Lasers are now regarded as one of the key technologies in line with the national policy toward the creation of innovative industries. Realization of the laser fusion reactor is the most challenging target in the coming thirty years. (S. Funahashi)

  13. Deterrence, denuclearization, and proliferation: Alternative visions of the next fifty years

    Energy Technology Data Exchange (ETDEWEB)

    Lehman, R.F. II

    1994-02-12

    The great library of Alexandria may have contained fewer volumes than the number which have been written on the subject of nuclear weapons in the Cold War. With the end of the Cold War, a new nuclear library is in the making. Much thought is being given to the next steps in nuclear policy, strategy, forces, arms control, and nonproliferation. For this very distinguished conference, however, I have been asked to look further ahead indeed, forward fifty-years. Prognostication is always a risky business. Detailed predictions beyond the shortest duration are difficult to label as ``scientific`` even in the social sciences. Forecasting ahead fifty years in an age of ever accelerating change would seem to be hopeless. Projecting the future of nuclear weapons, however, may not be as complex as one might think. Detailing the future fifty years from now is not necessary. We want to inform upcoming decisions by examining the possibilities, not write a history in advance of what is to happen. Our look forward con benefit from a brief look back fifty years. In retrospect, those years passed quickly, and with each additional year, analysts make them appear more simple than they seemed at the time. This paper contributes further to this process of oversimplification, as we say, ``for heuristic purposes.`` When in doubt, I have erred on the side of being provocative.

  14. Deterrence, denuclearization, and proliferation: Alternative visions of the next fifty years

    International Nuclear Information System (INIS)

    Lehman, R.F. II.

    1994-01-01

    The great library of Alexandria may have contained fewer volumes than the number which have been written on the subject of nuclear weapons in the Cold War. With the end of the Cold War, a new nuclear library is in the making. Much thought is being given to the next steps in nuclear policy, strategy, forces, arms control, and nonproliferation. For this very distinguished conference, however, I have been asked to look further ahead indeed, forward fifty-years. Prognostication is always a risky business. Detailed predictions beyond the shortest duration are difficult to label as ''scientific'' even in the social sciences. Forecasting ahead fifty years in an age of ever accelerating change would seem to be hopeless. Projecting the future of nuclear weapons, however, may not be as complex as one might think. Detailing the future fifty years from now is not necessary. We want to inform upcoming decisions by examining the possibilities, not write a history in advance of what is to happen. Our look forward con benefit from a brief look back fifty years. In retrospect, those years passed quickly, and with each additional year, analysts make them appear more simple than they seemed at the time. This paper contributes further to this process of oversimplification, as we say, ''for heuristic purposes.'' When in doubt, I have erred on the side of being provocative

  15. What history tells us XIII. Fifty years of the Central Dogma

    Indian Academy of Sciences (India)

    2008-05-14

    May 14, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 2. What history tells us XIII. Fifty years of the Central Dogma. Michel Morange. Series Volume 33 Issue 2 June 2008 pp 171-175. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/033/02/0171-0175 ...

  16. Fifty years of continuous improvement: (What has DOE done for analytical chemistry?)

    Energy Technology Data Exchange (ETDEWEB)

    Shults, W.D.

    1993-11-01

    Over the past fifty years, analytical scientist within the DOE complex have had a tremendous impact on the field of analytical chemistry. This paper suggests six ``high impact`` research/development areas that either originated within or were brought to maturity within the DOE laboratories. ``High impact`` means they lead to new subdisciplines or to new ways of doing business.

  17. Domain analysis of computational science - Fifty years of a scientific computing group

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, M.

    2010-02-23

    I employed bibliometric- and historical-methods to study the domain of the Scientific Computing group at Brookhaven National Laboratory (BNL) for an extended period of fifty years, from 1958 to 2007. I noted and confirmed the growing emergence of interdisciplinarity within the group. I also identified a strong, consistent mathematics and physics orientation within it.

  18. The history of fifty years of institute of electrical engineers 1947-1996

    International Nuclear Information System (INIS)

    1997-07-01

    This book starts with the survey of a century of Korea electrical industry. It includes a business of electric power and electrical machinery industry. Next, it deals with the survey of fifty years of Korea institute electrical engineers. Then, it enumerates the articles of association, organization, board members, the role of the administrative organization, study and institute business activities in detail.

  19. Fifty years of entomological publications in the Revista de Biología Tropical.

    Science.gov (United States)

    Hanson, Paul

    2002-01-01

    Over its fifty year history nearly twenty percent of the papers published in the Revista de Biología Tropical have been about insects and arachnids. In the 1950's papers on arthropods of medical importance were dominant, in the 1960's there was a poliferation of papers on bees, and in more recent years the subjects have become increasingly diverse. In terms of nationality of contributing authors, the journal appears to have become increasingly international in later years.

  20. Fifty years experiences in nuclear engineering education at Tokyo Institute of Technology

    International Nuclear Information System (INIS)

    Fujii, Yasuhiko; Saito, Masaki; Aritomi, Masanori

    2008-01-01

    Nuclear engineering education has been initiated in 1957 at the graduate school of Tokyo Institute of Technology. Educational activities have been conducted for fifty years under the support of the Research Laboratory for Nuclear Reactors. In the past fifty years, about 1000 Master students and 200 Doctoral students and 200 Doctoral students graduated from our Nuclear Engineering Department at Tokyo Institute of Technology. Many of them found their jobs in nuclear industries and institutes. International course of nuclear engineering was initiated in 1994, and so far about 90 students from 15 overseas countries have graduated from our Master and Doctoral Programs. In 2003, our proposal of 'Innovative Nuclear Energy System for the Sustainable World' was adopted as the Center of Excellent Program sponsored by Ministry of Education, Science and Technology. Recently a collaborative education network has been developed among Kanazawa University, Fukui University, Ibaraki University, Okayama University, Tokyo Institute of Technology and Japan Atomic Energy Agency. (author)

  1. L'etat, c'est moi. Fifty years of history and philosophy of evolutionary biology.

    Science.gov (United States)

    Ruse, Michael

    2016-01-01

    I reflect on my fifty-year history as a philosopher of biology, showing how it has taken me from rather narrow analytic studies, through the history of ideas, and now on to issues to do with science and religion. I argue that moral concerns were and still are a major motivation behind what I do and write. Copyright: © 2016 by Fabrizio Serra editore, Pisa · Roma.

  2. The Henderson Question? The Melbourne Institute and fifty years of welfare policy

    OpenAIRE

    R. G. Gregory

    2013-01-01

    We discuss selected research contributions of the Melbourne Institute of Applied Economics and Social Research, to fifty years of welfare policy for those of work force age and focus particularly on the policy focus of R. F. Henderson, the inaugural director. Following the spirit of his 1960s poverty research, government, in the mid-1970s, doubled unemployment allowances in real terms and increased pensions by approximately forty per cent. Both income support payments were to be indexed by av...

  3. One hundred and fifty years of combustion of fossil hydrocarbons: The emergent alternatives

    International Nuclear Information System (INIS)

    Laine, Jorge

    2009-01-01

    After one hundred fifty years of drilling first commercial petroleum wells that led to the intensive use of liquid fuels to move transport vehicles, we are arriving at the peak of the world-wide petroleum reserves. Yet, we still have a good portion for spending, with the hope that the consequences will be better than in the first part, which has implied several wars and deteriorations of the environment. This assay brings a review about the history of fossil fuels and with the prospective of the emergent energetic alternatives, placing emphasis on bioenergy as an alternative for the transition between the actual combustion age and the new age of clean energy.

  4. The continuous time random walk, still trendy: fifty-year history, state of art and outlook

    Science.gov (United States)

    Kutner, Ryszard; Masoliver, Jaume

    2017-03-01

    In this article we demonstrate the very inspiring role of the continuous-time random walk (CTRW) formalism, the numerous modifications permitted by its flexibility, its various applications, and the promising perspectives in the various fields of knowledge. A short review of significant achievements and possibilities is given. However, this review is still far from completeness. We focused on a pivotal role of CTRWs mainly in anomalous stochastic processes discovered in physics and beyond. This article plays the role of an extended announcement of the Eur. Phys. J. B Special Issue [open-calls-for-papers/123-epj-b/1090-ctrw-50-years-on">http://epjb.epj.org/open-calls-for-papers/123-epj-b/1090-ctrw-50-years-on] containing articles which show incredible possibilities of the CTRWs. Contribution to the Topical Issue "Continuous Time Random Walk Still Trendy: Fifty-year History, Current State and Outlook", edited by Ryszard Kutner and Jaume Masoliver.

  5. The Research of Dr. Joanne Simpson: Fifty Years Investigating Hurricanes, Tropical Clouds and Cloud Systems

    Science.gov (United States)

    Tao, W. -K.; Halverson, J.; Adler, R.; Garstang, M.; Houze, R., Jr.; LeMone, M.; Pielke, R., Sr.; Woodley, W.; O'C.Starr, David (Technical Monitor)

    2001-01-01

    This AMS Meteorological Monographs is dedicated to Dr. Joanne Simpson for her many pioneering research efforts in tropical meteorology during her fifty-year career. Dr. Simpson's major areas of scientific research involved the "hot tower" hypothesis and its role in hurricanes, structure and maintenance of trade winds, air-sea interaction, and observations and the mechanism for hurricanes and waterspouts. She was also a pioneer in cloud modeling with the first one-dimensional model and had the first cumulus model on a computer. She also played a major role in planning and leading observational experiments on convective cloud systems. The launch of the Tropical Rainfall Measuring Mission (TRMM) satellite, a joint U.S.-Japan project, in November of 1997 made it possible for quantitative measurements of tropical rainfall to be obtained on a continuous basis over the entire global tropics. Dr. Simpson was the TRAM Project Scientist from 1986 until its launch in 1997. Her efforts during this crucial period ensured that the mission was both well planned scientifically and well engineered as well as within budget. In this paper, Dr. J. Simpson's nine specific accomplishments during her fifty-year career: (1) hot tower hypothesis, (2) hurricanes, (3) airflow and clouds over heated islands, (4) cloud models, (5) trade winds and their role in cumulus development, (6) air-sea interaction, (7) cloud-cloud interactions and mergers, (8) waterspouts, and (9) TRMM science, will be described and discussed.

  6. Fifty years of fat: news coverage of trends that predate obesity prevalence.

    Science.gov (United States)

    Davis, Brennan; Wansink, Brian

    2015-07-10

    Obesity prevalence has risen in fifty years. While people generally expect media mentions of health risks like obesity prevalence to follow health risk trends, food consumption trends may precede obesity prevalence trends. Therefore, this research investigates whether media mentions of food predate obesity prevalence. Fifty years of non-advertising articles in the New York Times (and 17 years for the London Times) are coded for the mention of less healthy (5 salty and 5 sweet snacks) and healthy (5 fruits and 5 vegetables) food items by year and then associated with annual obesity prevalence in subsequent years. Time-series generalized linear models test whether food-related mentions predate or postdate obesity prevalence in each country. United States obesity prevalence is positively associated with New York Times mentions of sweet snacks (b = 55.2, CI = 42.4 to 68.1, p = .000) and negatively associated with mentions of fruits (b = -71.28, CI -91.5 to -51.1, p = .000) and vegetables (b = -13.6, CI = -17.5 to -9.6, p = .000). Similar results are found for the United Kingdom and The London Times. Importantly, the "obesity followed mentions" models are stronger than the "obesity preceded mentions" models. It may be possible to estimate a nation's future obesity prevalence (e.g., three years from now) based on how frequently national media mention sweet snacks (positively related) and vegetables or fruits (negatively related) today. This may provide public health officials and epidemiologists with new tools to more quickly assess the effectiveness of current obesity interventions based on what is mentioned in the media today.

  7. Nuclear power: A look at the future. International Conference on Fifty Years of Nuclear Power: The Next Fifty Years, 27 June 2004, Moscow, Russia

    International Nuclear Information System (INIS)

    ElBaradei, M.

    2004-01-01

    other electricity sources. Critical Issues in Shaping the Future are: Carbon Emissions and the Growth in Demand; Security of Supply; Public Perceptions and Misconceptions: Shaping National Choices; Performance in Addressing Key Concerns: Nuclear Safety, Management and Disposal of Spent Nuclear Fuel, Nuclear Security, Technological and Policy Innovation, Fuel for Transportation (Growing Interest in the Potential for a 'Hydrogen Economy'). Although it is difficult to predict with any confidence what the next fifty years holds for nuclear power, the factors that will shape the future of nuclear power are relatively evident, and action should ne taken to address those factors, to enhance the prospects that nuclear energy remains a viable source of safe, secure and environmentally benign energy

  8. The richness of discovery : Amoco's first fifty years in Canada (1948-1998)

    International Nuclear Information System (INIS)

    McKenzie-Brown, P.

    1998-01-01

    A review of Amoco's first fifty years of operations in Canada, including investments, discoveries, and policies was presented. While no claim is made for this attractively produced slim volume to be a definitive history, it does manage to shed light on some of the great achievements and outstanding deeds of the people behind the company. The book provides a glimpse into how Amoco contributed to the growth of the Canadian petroleum industry in diverse areas including the manufacturing sector, the petroleum service sector, oil field technology, oil field infrastructure and petrochemical development. The company enjoyed spectacular success during the 1950s and 1960s. As evidence of that success, in 1997 Amoco Canada was the largest Canadian producer and exporter of natural gas and NGLs, the largest cold producer of heavy oil, the second largest in situ producer of heavy oil, and one of the 10 largest producers of conventional oil. refs., tabs., figs

  9. Gauge evolution of elementary particles physics during the last fifty years

    International Nuclear Information System (INIS)

    Khodjaev, L.Sh

    2002-01-01

    Gauge evolution of the elementary particle physics has been remarked by outstanding and exiting discoveries during the last fifty years of X X century. We review a new tendency in the development of the modern elementary particle physics. The phenomenological basis for the formulation of Standard Model has been reviewed. The Standard Model based on the fundamental postulates has been formulated. The concept of the fundamental symmetries has been introduced to look for not fundamental particles but fundamental symmetries. The Standard Model is renormalizable and therefore potentially consistent in all energy scales. The Standard Model in principle can describe the properties of the Universe beginning at 10 -43 sec. after Big Bang. In searching of more general theory obvious program is to searching the first of all global symmetries and then learn consequences connected with the localization of these global symmetries

  10. Venice: Fifty years after the great flood of November 4, 1966

    Science.gov (United States)

    Rizzoli, P. M.

    2017-12-01

    Fifty years ago Venice and its lagoon suffered the most devastating flood in their millennial history. The causes of the increasingly recurring floods will be examined, namely the man-induced subsidence in the period 1925-1970 and the storm surges of the Adriatic sea. The engineering solution designed for their protection , named the MOSE system, will be discussed in detail. The MOSE was started in 2003 and is near completion. It consists of four barriers , invisible in normal conditions, which will close the inlets to the lagoon under the prediction of a forthcoming flood. Finally, the perspective of the MOSE capability of protecting the city under scenarios of future global sea level rise will be assessed. This assessment must critically take into account that Venice and its lagoon are confined in the northernmost corner of the semi-enclosed, marginal Mediterranean sea for which the uncertainties of future sea level rise greatly exceed the uncertainties of the global averages.

  11. Organ Transplantation and the Uniform Anatomical Gift Act: A Fifty-Year Perspective.

    Science.gov (United States)

    Sadler, Blair L; Sadler, Alfred M

    2018-03-01

    Fifty years ago this summer, the Uniform Anatomical Gift Act was adopted by the National Conference of Commissioners on Uniform State Laws and approved by the American Bar Association. The UAGA has provided a sound and stable legal platform on which to base an effective nationwide organ donation system. The cardinal principles of altruism, autonomy, and public trust are still important. At a time when confidence and trust in our government and many private institutions has declined, maintaining trust and confidence in our health care system and its commitment to "first, do no harm" has never been more important. Any policies that override these core ethical principles could cause irreparable damage to the public's faith in our transplant system. While progress has been made to increase organ registration and the number of organs transplanted, much more must be done to realize the potential of life-saving therapy without jeopardizing ethical principles. © 2018 The Hastings Center.

  12. Fifty years of herbicide research: comparing the discovery of trifluralin and halauxifen-methyl.

    Science.gov (United States)

    Epp, Jeffrey B; Schmitzer, Paul R; Crouse, Gary D

    2018-01-01

    Fifty years separate the commercialization of the herbicides trifluralin and halauxifen-methyl. Despite the vast degree of technological change that occurred over that time frame, some aspects of their discovery stories are remarkably similar. For example, both herbicides were prepared very early in the iterative discovery process and both were developed from known lead compound structures by hypothesis-driven research efforts without the use of in vitro assays or computer-aided molecular design. However, there are aspects of the halauxifen-methyl and trifluralin discovery stories that are substantially different. For example, the chemical technology required for the cost-effective production of halauxifen-methyl simply did not exist just two decades prior to its commercial launch. By contrast, the chemical technology required for the cost-effective production of trifluralin was reported in the chemical literature more than two decades prior to its commercial launch. In addition, changes in regulatory environment since the early 1960s ensured that their respective discovery to commercial launch stories would also differ in substantial ways. Ultimately, the time and cost required to develop and register halauxifen-methyl demanded a global initial business case while the lower registration hurdles that trifluralin cleared enabled a narrow initial business case mainly focused on the USA. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  13. Age-dependent salt hypertension in Dahl rats: fifty years of research.

    Science.gov (United States)

    Zicha, J; Dobešová, Z; Vokurková, M; Rauchová, H; Hojná, S; Kadlecová, M; Behuliak, M; Vaněčková, I; Kuneš, J

    2012-01-01

    Fifty years ago, Lewis K. Dahl has presented a new model of salt hypertension - salt-sensitive and salt-resistant Dahl rats. Twenty years later, John P. Rapp has published the first and so far the only comprehensive review on this rat model covering numerous aspects of pathophysiology and genetics of salt hypertension. When we summarized 25 years of our own research on Dahl/Rapp rats, we have realized the need to outline principal abnormalities of this model, to show their interactions at different levels of the organism and to highlight the ontogenetic aspects of salt hypertension development. Our attention was focused on some cellular aspects (cell membrane function, ion transport, cell calcium handling), intra- and extrarenal factors affecting renal function and/or renal injury, local and systemic effects of renin-angiotensin-aldosterone system, endothelial and smooth muscle changes responsible for abnormal vascular contraction or relaxation, altered balance between various vasoconstrictor and vasodilator systems in blood pressure maintenance as well as on the central nervous and peripheral mechanisms involved in the regulation of circulatory homeostasis. We also searched for the age-dependent impact of environmental and pharmacological interventions, which modify the development of high blood pressure and/or organ damage, if they influence the salt-sensitive organism in particular critical periods of development (developmental windows). Thus, severe self-sustaining salt hypertension in young Dahl rats is characterized by pronounced dysbalance between augmented sympathetic hyperactivity and relative nitric oxide deficiency, attenuated baroreflex as well as by a major increase of residual blood pressure indicating profound remodeling of resistance vessels. Salt hypertension development in young but not in adult Dahl rats can be attenuated by preventive increase of potassium or calcium intake. On the contrary, moderate salt hypertension in adult Dahl rats is

  14. Emerging frontiers of pharmacy education in Saudi Arabia: The metamorphosis in the last fifty years.

    Science.gov (United States)

    Asiri, Yousif A

    2011-01-01

    The trends in the quality of biomedical education in pharmacy schools have witnessed significant changes in the 21st century. With the advent of continuous revision and standardization processes of medical curricula throughout the world, the focus has been on imparting quality education. This pedagogic paradigm has shifted to pharmacy schools. In Saudi Arabia, the concept of "medical and pharmacy education" is relatively new as mainstream pharmacy curriculum and universities were established only half a century ago. This period has seen major changes in the dimension of "pharmacy education" to keep pace with the education systems in the United States and Europe. As our knowledge and perceptions about pharmaceuticals change with time, this motivates educators to search for better teaching alternatives to the ever increasing number of enthusiastic and budding pharmacists. Recently, the academic system in Saudi Arabian Pharmacy has adopted a more clinically-oriented Pharm. D. curriculum. This paper deals with the major changes from the inception of a small pharmacy faculty in 1959, the College of Pharmacy at the King Saud University, Riyadh, to the model of progress and a prototype of pharmacy colleges in Saudi Arabia. The fifty year chronological array can be regarded as an epitome of progress in pharmacy education in Saudi Arabia from its traditional curriculum to the modern day Pharm. D. curriculum with a high population growth and expanding health care sector, the demand for qualified pharmacists is growing and is projected to grow considerably in the future. The number of pharmacy graduates is increasing each year by many folds and to meet the needs the system lays stress upon a constant revising and updating of the current curriculum from a global perspective.

  15. Fifty Years of Safeguards under the EURATOM Treaty. A Regulatory Review

    International Nuclear Information System (INIS)

    Patel, B.; Chare, P.

    2007-01-01

    March 2007 marked the 50th anniversary of the signing of one of the founding treaties of the European Community. The EURATOM Treaty has its origins at a time when the stability of energy supplies in Europe was a major concern. Recently, much debate has centred on the possible reform or repeal of some parts of the treaty, given that its original aim was to promote and oversee the development of nuclear energy in Europe. This debate has focused attention on the future contribution of nuclear power to increasing energy demands in an enlarged Europe. However, despite these issues there is near universal agreement that the EURATOM Treaty has played a vital role in the protection of European citizens through the controls required for nuclear materials. Chapter 7 of the treaty (Safeguards) confers wide regulatory powers to the European Commission to ensure that civil nuclear materials are not diverted from their intended use as declared by the operators. This paper describes the early period of operation of the safeguards inspectorate, and gives statistics on the numbers and types of inspections carried out by the EURATOM inspectors, and discusses from an operational point of view the value of inspection activities. Further, a critical appraisal of Articles 77-85 within Chapter 7 is made. The paper also considers those safeguards requirements that are important to strengthen, in order to maintain a strong regulatory system to oversee future challenges, particularly in the context of increasing decommissioning activities within Europe. It is noteworthy that fifty-years after the founding of the treaty, many of the concerns about security of energy supply have re-emerged. It is a measure of the vision and forward thinking of its founders that the treaty has successfully overseen the safe and secure development of nuclear power in Europe (which currently provides a third of its electricity needs) and despite the many changes and developments that have occurred, that the

  16. Celebrating fifty years of research and applications in reminiscence and life review: State of the art and new directions

    NARCIS (Netherlands)

    Westerhof, Gerben Johan; Bohlmeijer, Ernst Thomas

    2014-01-01

    Fifty years ago, psychiatrist Robert Butler (1963) published an influential article on the recollection and evaluation of personal memories in later life. We discuss the major insights and applications in psychological gerontology that were inspired by Butler. Reminiscence and life review serve to

  17. [Trends in the mortality of liver cancer in Qidong, China: an analysis of fifty years].

    Science.gov (United States)

    Chen, Jian-guo; Zhu, Jian; Zhang, Yong-hui; Chen, Yong-sheng; Ding, Lu-lu; Lu, Jian-hua; Zhu, Yuan-rong

    2012-07-01

    To describe and analyze the charecteristics and trends of liver cancer mortality during the past fifty years in Qidong, China. Retrospective mortality survey was conducted to get the data on liver cancer death in the period of 1958-1971, and the data from 1972 to 2007 were obtained from the records of cancer registration in Qidong. The crude mortality rate (CR) of liver cancer, and age-standardized rate by Chinese population (CASR) and by world population (WASR) were calculated and analyzed. The total percent changes (PC) and annual percent changes (APC) were used for evaluating the increasing trends of the mortality. The sex-specific rate, age-specific rate, truncated rate of the age group 35 - 64, cumulative rate of the age group 0-74, cumulative risk, period-rate, and the rate for age-birth cohort were compared. The natural death rate in Qidong residents for the past five-decade period experienced a wave interval of 8.62‰ in 1958 down to 5.37‰ in 1979, and up to 7.75‰ in 2007. The mortality rate for all-site cancers was increased from 56.69 per 100, 000 to 234.97 per 100, 000. The mortality rate of liver cancer, being 20.45 per 100, 100 in 1958 was increased to 49.04 per 100, 000 in 1972, and up to 69.29 per 100, 000 in 2007. According to the registration data of 1972 - 2007, the death from liver cancer was accounted for 34.88% of all deaths due to cancers, with a CR of 58.86 per 100, 000, CASR of 38.36 per 100, 000, and WASR, 49.37 Per 100, 000 in Qidong. The truncated rate for the age group 35 - 64 was 117.08 per 100, 000, and the cumulative rate for the age group 0-74 and the cumulative risk were 5.15% and 5.02%, respectively. The CRs for males was 90.52 per 100, 000 and for females was 27.93 per 100, 000, with a sex ratio of 3.24:1. For the period of 1972 - 2007, the PC for CR was 49.71%, and APC was +1.41%, showing an increasing variation tendency. The APCs for CASR and WASR, however, were decreasing, with a percentage of -1.11%, and -0

  18. Fifty years of plutonium exposure to the Manhattan Project plutonium workers: an update.

    Science.gov (United States)

    Voelz, G L; Lawrence, J N; Johnson, E R

    1997-10-01

    Twenty-six white male workers who did the original plutonium research and development work at Los Alamos have been examined periodically over the past 50 y to identify possible health effects from internal plutonium depositions. Their effective doses range from 0.1 to 7.2 Sv with a median value of 1.25 Sv. As of the end of 1994, 7 individuals have died compared with an expected 16 deaths based on mortality rates of U.S. white males in the general population. The standardized mortality ratio (SMR) is 0.43. When compared with 876 unexposed Los Alamos workers of the same period, the plutonium worker's mortality rate was also not elevated (SMR = 0.77). The 19 living persons have diseases and physical changes characteristic of a male population with a median age of 72 y (range = 69 to 86 y). Eight of the twenty-six workers have been diagnosed as having one or more cancers, which is within the expected range. The underlying cause of death in three of the seven deceased persons was from cancer, namely cancer of prostate, lung, and bone. Mortality from all cancers was not statistically elevated. The effective doses from plutonium to these individuals are compared with current radiation protection guidelines.

  19. SINGAPORE'S DEMOGRAPHIC TRANSITION, THE LABOR FORCE AND GOVERNMENT POLICIES: THE LAST FIFTY YEARS

    OpenAIRE

    MUI TENG YAP; CHRISTOPHER GEE

    2015-01-01

    The trajectory of Singapore's population size and composition can be mapped out with its progression through the various phases of demographic transition from high birth and death rates in the post-war years to very low birth and death rates today, all within the context of rapid economic and social development that has taken place in the past 50 years. Population planning has been integral in Singapore's national development strategy, balancing the economy's needs for more and better qualifi...

  20. Fifty years of advances in sarcoma treatment: moving the needle from conventional chemotherapy to targeted therapy.

    Science.gov (United States)

    Patel, Shreyaskumar R

    2014-01-01

    Much of the progress in systemic therapy for sarcomas was accomplished in the first half of the last 5 decades. Various chemotherapeutic agents were tested in the 70s through the 80s and became part of the standard of care for this patient population. During the decade of the 90s, dose intensification became feasible as a result of improved supportive care and the availability of growth factors, thus maximizing the therapeutic potential of this class of agents. However, response rates and survival plateaued and it became obvious that newer and mechanistically different agents were needed to improve the therapeutic index and gain further enhancement of outcomes. Since early 2000, primarily inspired by the experience with imatinib in gastrointestinal stromal tumors (GISTs), several targeted therapies have been tested in sarcomas with modest success. The major limitations encountered include the lack of drivers and actionable targets for bone and soft tissue sarcomas with complex genomic profiles. Continued investigations and sequencing of larger numbers of these rare and heterogeneous malignancies could shed some light on a path toward improved outcomes.

  1. Fifty years with the Hamilton scales for anxiety and depression. A tribute to Max Hamilton

    DEFF Research Database (Denmark)

    Bech, P; Bech, P

    2009-01-01

    as the method for the evaluation of the clinical effects of psychotropic drugs. Inspired by Eysenck, Hamilton took the long route around factor analysis in order to qualify his scales for anxiety (HAM-A) and depression (HAM-D) as scientific tools. From the moment when, 50 years ago, Hamilton published his first...... placebo-controlled trial with an experimental anti-anxiety drug, he realized the dialectic problem in using the total score on HAM-A as a sufficient statistic for the measurement of outcome. This dialectic problem has been investigated for more than 50 years with different types of factor analyses without...

  2. Fifty-Year Trends in the Chemical Industry: What Do They Mean for Chemical Education?

    Science.gov (United States)

    Tolman, Chadwick A.; Parshall, George W.

    1999-01-01

    Describes major changes that have occurred in the chemical industry over the last 50 years including trends in the development of products and processes, changes in chemical manufacturing, the globalization of business, and modifications of research laboratory practices. Discusses implications for chemistry education and predictions for future…

  3. Rosalind Franklin: The Woman Scientist of DNA It is fifty years since ...

    Indian Academy of Sciences (India)

    milind1

    awarded the Nobel Prize as it is not given posthu- mously. ... photographs are among the most beautiful of any substance ... during World War II, and Franklin investigated why some ... fered her only a three-year fellowship, with nei- ther rank ...

  4. The Kitty Genovese Story in Introductory Psychology Textbooks: Fifty Years Later

    Science.gov (United States)

    Griggs, Richard A.

    2015-01-01

    Given the many inaccuracies in the original "New York Times" 38-witnesses version of the Kitty Genovese story, this study examined the accuracy of this story in current introductory psychology textbooks, 50 years later. Recent studies have shown that there is no evidence for the following three key features of the original story: (1)…

  5. Open oakwoods facing modern threats: Will they survive the next fifty years?

    Czech Academy of Sciences Publication Activity Database

    Chudomelová, Markéta; Hédl, Radim; Zouhar, V.; Szabó, Péter

    2017-01-01

    Roč. 210, Part A (2017), s. 163-173 ISSN 0006-3207 R&D Projects: GA ČR GA17-09283S EU Projects: European Commission(XE) 278065 - LONGWOOD Institutional support: RVO:67985939 Keywords : community change * open oakwoods * canopy closure Subject RIV: EH - Ecology, Behaviour OBOR OECD: Ecology Impact factor: 4.022, year: 2016

  6. Fifty years of solid-phase extraction in water analysis--historical development and overview.

    Science.gov (United States)

    Liska, I

    2000-07-14

    The use of an appropriate sample handling technique is a must in an analysis of organic micropollutants in water. The efforts to use a solid phase for the recovery of analytes from a water matrix prior to their detection have a long history. Since the first experimental trials using activated carbon filters that were performed 50 years ago, solid-phase extraction (SPE) has become an established sample preparation technique. The initial experimental applications of SPE resulted in widespread use of this technique in current water analysis and also to adoption of SPE into standardized analytical methods. During the decades of its evolution, chromatographers became aware of the advantages of SPE and, despite many innovations that appeared in the last decade, new SPE developments are still expected in the future. A brief overview of 50 years of the history of the use of SPE in organic trace analysis of water is given in presented paper.

  7. Introduction to the focus issue: fifty years of chaos: applied and theoretical.

    Science.gov (United States)

    Hikihara, Takashi; Holmes, Philip; Kambe, Tsutomu; Rega, Giuseppe

    2012-12-01

    The discovery of deterministic chaos in the late nineteenth century, its subsequent study, and the development of mathematical and computational methods for its analysis have substantially influenced the sciences. Chaos is, however, only one phenomenon in the larger area of dynamical systems theory. This Focus Issue collects 13 papers, from authors and research groups representing the mathematical, physical, and biological sciences, that were presented at a symposium held at Kyoto University from November 28 to December 2, 2011. The symposium, sponsored by the International Union of Theoretical and Applied Mechanics, was called 50 Years of Chaos: Applied and Theoretical. Following some historical remarks to provide a background for the last 50 years, and for chaos, this Introduction surveys the papers and identifies some common themes that appear in them and in the theory of dynamical systems.

  8. Financial requirements and manpower needs of nuclear energetics for the next fifty years

    International Nuclear Information System (INIS)

    Spital'nik, Dzh.

    1997-01-01

    Forecasts on financial and manpower requirements of rich and poor countries for NPPs construction by 2050 showed that the NPPs capacities will increase from 320 up to 2500 GW, whereby the ratio between the rich and poor countries will constitute approximately 2:1. Investments in NPPs construction will equal from 1600 up to 2700 billions dollars. Global need in manpower for NPPs will constitute by 2050 240000 man/year

  9. The urban and territorial planning during the last fifty years in mexico

    OpenAIRE

    Ortiz Macedo, Luis

    2010-01-01

    The urban and territorial planning in Mexico started late, and always federal, state and local governments haven’t been able to forecast the long term issues, but instead the long seventy years in which the governors were supported by the Partido Revolucionario Institucional (PRI) started urban structures that were never finished by their successors. However, depending on successive Secretaries of State planning programs have been made relying on national and international specialists, but th...

  10. Carbon Stocks across a Fifty Year Chronosequence of Rubber Plantations in Tropical China

    Directory of Open Access Journals (Sweden)

    Chenggang Liu

    2017-06-01

    Full Text Available Transition from forest to rubber (Hevea brasiliensis Muell. Arg. plantation has occurred in tropical China for decades. Rubber has been planted on 1 million ha to provide raw materials to the rubber industry. The role of various-aged rubber plantations in carbon (C sequestration remains unclear. The biomass C accumulation including latex C and C distribution in soil of five different-aged stands (7, 13, 19, 25 and 47 years old were examined. The total biomass C stock (TBC and total net primary productivity (NPPtotal, whether with or without latex C, had a close quadratic relationship with stand age. Regardless of stand age, around 68% of the C was stored in aboveground biomass, and NPPlatex contributed to approximately 18% of C sequestration. Soil organic carbon stock in the 100-cm depth remained relatively stable, but it lost about 16.8 Mg ha−1 with stand age. The total ecosystem C stock (TEC across stands averaged 159.6, 174.4, 229.6, 238.1 and 291.9 Mg ha−1, respectively, of which more than 45% was stored in the soil. However, biomass would become the major C sink rather than soil over a maximal rubber life expectancy. Regression analysis showed that TEC for rubber plantation at 22 years is comparable to a baseline of 230.4 Mg ha−1 for tropical forest in China, and would reach the maximum value at around 54 years. Therefore, rubber plantation can be considered as alternative land use without affecting net forest ecosystem C storage. In addition to the potential C gains, a full set of ecosystem and economic properties have to be quantified in order to assess the trade-offs associated with forest-to-rubber transition.

  11. Age-dependent salt hypertension in Dahl rats: fifty years of research

    Czech Academy of Sciences Publication Activity Database

    Zicha, Josef; Dobešová, Zdenka; Vokurková, Martina; Rauchová, Hana; Hojná, Silvie; Kadlecová, Michaela; Behuliak, Michal; Vaněčková, Ivana; Kuneš, Jaroslav

    2012-01-01

    Roč. 61, Suppl.1 (2012), S35-S87 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) 1M0510; GA ČR(CZ) GA305/09/0336; GA ČR(CZ) GAP304/12/0259 Institutional research plan: CEZ:AV0Z50110509 Institutional support: RVO:67985823 Keywords : blood pressure * cell membrane transport * hemodynamics * vasoactive systems * cell calcium handling Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery Impact factor: 1.531, year: 2012

  12. A vision for the second fifty years of nuclear energy. Vision and strategies

    International Nuclear Information System (INIS)

    Hori, M.

    1997-01-01

    The paper is the Polish issue of the report worked out by International Nuclear Societies Council published in 1996. The report contains the experts opinion on development of nuclear energy and applications of radiation techniques and sources worldwide during the next 50 years. The worldwide energy demand prognosis as well as needs of different branches of industry, agriculture, medicine, etc. have been taken into account. The broad spectrum of aspects (safety assurance, economy, environmental impacts) connected with nuclear technology utilization has been also discussed

  13. The 1953 Stanley L. Miller Experiment: Fifty Years of Prebiotic Organic Chemistry

    Science.gov (United States)

    Lazcano, Antonio; Bada, Jeffrey L.

    2003-01-01

    The field of prebiotic chemistry effectively began with a publication in Science 50 years ago by Stanley L. Miller on the spark discharge synthesis of amino acids and other compounds using a mixture of reduced gases that were thought to represent the components of the atmosphere on the primitive Earth. On the anniversary of this landmark publication, we provide here an accounting of the events leading to the publication of the paper. We also discuss the historical aspects that lead up to the landmark Miller experiment.

  14. A Fifty-Year Sustainability Assessment of Italian Agro-Forest Districts

    Directory of Open Access Journals (Sweden)

    Fabio Recanatesi

    2015-12-01

    Full Text Available As cropland management and land use shifted towards more intensive practices, global land degradation increased drastically. Understanding relationships between ecological and socioeconomic drivers of soil and landscape degradation within these landscapes in economically dynamic contexts such as the Mediterranean region, requires multi-target and multi-scalar approaches covering long-term periods. This study provides an original approach for identifying desertification risk drivers and sustainable land management strategies within Italian agro-forest districts. An Environmental Sensitivity Area (ESA approach, based on four thematic indicators (climate, soil, vegetation and land-use and a composite index of desertification risk (ESAI, was used to evaluate changes in soil vulnerability and landscape degradation between the years 1960 and 2010. A multivariate model was developed to identify the most relevant drivers causing changes in land susceptibility at the district scale. Larger districts, and those with a higher proportion of their total surface area classified as agro-forest, had a significantly lower increase in land susceptibility to degradation during the 50 years when compared with the remaining districts. We conclude that preserving economic viability and ecological connectivity of traditional, extensive agricultural systems is a key measure to mitigate the desertification risk in the Mediterranean region.

  15. Fifty Years of Burn Care at Shriners Hospitals for Children, Galveston.

    Science.gov (United States)

    Čapek, Karel D; Culnan, Derek M; Desai, Manubhai H; Herndon, David N

    2018-03-01

    More than 50 years ago, Shriners Hospitals for Children expanded their philanthropy to include care for burned children. In so doing, the effects of their work weightily expanded from rehabilitation and quality of life outcomes to include survival proper. As the first facility dedicated to the care of burned children, originally designated the Shriners Burn Institute, the Galveston hospital remains the cornerstone of this endeavor. Shriners maintains charitable pediatric hospitals, provide care irrespective of the patient's or the family's ability to pay, and promote research. The sole criterion for admission at Shriners Hospitals for Children is the determination by a surgeon at a Shriners hospital that "the child's trouble may be corrected or improved." This philanthropic effort to provide medical care for children is one expression of the human commonality recognized by Shriners. In this article, we provide some background information on how this hospital came into existence as well as a global summary of its interventions toward greater survival and more complete rehabilitation of burned children. Based on the findings presented herein, we assert that there is less suffering and less loss of life due to childhood burns today than in previous years. We attribute much of this improvement to the simple voluntary collective decision by Shriners to provide alms for burned children.

  16. Fifty years with the Hamilton scales for anxiety and depression. A tribute to Max Hamilton.

    Science.gov (United States)

    Bech, P

    2009-01-01

    From the moment Max Hamilton started his psychiatric education, he considered psychometrics to be a scientific discipline on a par with biochemistry or pharmacology in clinical research. His clinimetric skills were in operation in the 1950s when randomised clinical trials were established as the method for the evaluation of the clinical effects of psychotropic drugs. Inspired by Eysenck, Hamilton took the long route around factor analysis in order to qualify his scales for anxiety (HAM-A) and depression (HAM-D) as scientific tools. From the moment when, 50 years ago, Hamilton published his first placebo-controlled trial with an experimental anti-anxiety drug, he realized the dialectic problem in using the total score on HAM-A as a sufficient statistic for the measurement of outcome. This dialectic problem has been investigated for more than 50 years with different types of factor analyses without success. Using modern psychometric methods, the solution to this problem is a simple matter of reallocating the Hamilton scale items according to the scientific hypothesis under examination. Hamilton's original intention, to measure the global burden of the symptoms experienced by the patients with affective disorders, is in agreement with the DSM-IV and ICD-10 classification systems. Scale reliability and obtainment of valid information from patients and their relatives were the most important clinimetric innovations to be developed by Hamilton. Max Hamilton therefore belongs to the very exclusive family of eminent physicians celebrated by this journal with a tribute. 2009 S. Karger AG, Basel.

  17. One hundred and fifty years of Coulomb stress history along the California-Nevada border, USA

    Science.gov (United States)

    Verdecchia, Alessandro; Carena, Sara

    2015-02-01

    The region north of the Garlock Fault between the Sierra Nevada and Death Valley has experienced at least eight Mw ≥ 6 earthquakes in historical times, beginning with the 1872, Mw 7.5, Owens Valley earthquake. Furthermore, since 1978, the Long Valley Caldera has been undergoing periods of unrest, with earthquake swarms and resurgence. Our goal is to determine whether the 1872 Owens Valley earthquake and the caldera unrest have influenced the evolution of seismicity in the area. We model the evolution of coseismic, postseismic, and interseismic Coulomb stress change (Coulomb failure stress (ΔCFS)) in the region due to both Mw ≥ 6 earthquakes and caldera inflation in the last 150 years. Our results show that the 1872 Owens Valley earthquake has an important influence on subsequent events, strongly encouraging faulting in northern Owens Valley while inhibiting it elsewhere. There is also a correlation between caldera inflation and seismicity in northern Owens Valley, evidenced by the west-to-east migration of earthquakes from the Long Valley Caldera toward the White Mountains immediately following the 1978 caldera inflation event. Finally, we show that a total ΔCFS increase of up to 30 bars in the last 150 years has occurred on part of the White Mountains fault, making it a possible candidate for the next major earthquake in this region.

  18. White paper on science and technology, 1995. Fifty years of postwar science and technology in Japan

    International Nuclear Information System (INIS)

    1995-07-01

    This August marks 50 years since the end of World War II. Japan emerged from the ruins to overcome the post-war devastation to achieve a high level of economic growth and become the second largest economy in the world. Science and technology have played major roles as a driving force behind this quest for prosperity. However, it seems as though true prosperity is not necessarily being enjoyed by citizens of Japan today. Japan is becoming an aging society. To realize a truly rich and prosperous society in which people can live comfortably, it is important to further raise the level of science and technology. It is also necessary to ensure this development by revitalizing the economy, and to continue to utilize science and technology as an endless resource to create assets for society as a whole which will be inherited by future generations. With this viewpoint in mind, this White Paper looks back on Japan's scientific and technological development over the last 50 years, and considers the future of science and technology with a view toward realizing the true prosperity for its people. It is our hope that this White Paper will be helpful for considering the scientific and technological activities needed to bring about a Japan whose people are truly prosperous, and we will, as a government, continually increase our efforts toward the promotion of science and technology. (J.P.N.)

  19. Oil prices touch fifty year low - industry gears up for further cuts in operating costs

    International Nuclear Information System (INIS)

    Anon.

    1999-01-01

    International crude oil prices hit a 50-year low (inflation adjusted) in December 1998. Prices are now lower than in 1973 and are expected to remain low for several years; so much so that the future of production activities are under threat. The paper goes on to discuss the UK Government's initiative to tackle the problem and of the activities of the CRINE (Cost Reduction in the New Era) Network to reduce operating costs. The Government Oil and Gas Task Force aimed to develop strategies to reduce the cost base of UK gas and oil operations and recommend action by Government and/or the industry by summer 1999. The concern is that current costs of production on the UK continental shelf will make new offshore development uneconomic. A meeting in January 1999 agreed six key areas for action. The work of the Task Force overlaps that of Crine which, since 1992 has been working to drive down capital costs of developing oil and gas fields by innovative approaches including cooperation between companies. (UK)

  20. Fifty years of levelling measurements at Askja volcano, Iceland: New Bayesian interpretations of a unique dataset

    Science.gov (United States)

    Barnie, Talfan; Sigmundsson, Freysteinn; Sturkell, Erik

    2017-04-01

    The year 2016 marks the 50th anniversary of the start of geodetic levelling surveys at Askja volcano in the Northern Volcanic Zone of Iceland. Askja has produced frequent basaltic fissural eruptions and rarer silicic caldera forming eruptions during the Holocene, the most recent of each type in 1961 and 1875 respectively. The potential for widespread disruption from larger eruptions and the popularity of the site with tourists makes Askja an important target for observation. Geodetic monitoring started in 1966 with the installation of a 12 station survey line on the 1961 lava flow, which provided a stable, extensive surface close to the putative source of magma. This was infilled and extended over the following two decades to give a finished levelling line of 35 stations spaced approximately 50 m apart (Tryggvason, Nordic Volcanological Institute, 1989). With the exception of the period 1972 to 1983, this line has been surveyed every year, providing a unique record of post eruptive deformation at a spreading rift segment capable of capturing magma motions at depth and any potential recharging in anticipation of future activity. The levelling has so far revealed that after an initial period of complicated inflations and deflations the volcano settled into a pattern of slowly decaying deflation from 1983 onwards (Sturkell and Sigmundsson, JGR, 105, 2000), a pattern that has been confirmed by newer geodetic techniques as they have become available (e.g. Pagli et al., JVGR, 152, 2005). The strength of the levelling data at Askja is its long time span, high accuracy and same measurement type over a period of 50 years. However, the small extent of the levelling line limits the power of the network to resolve changes in the magma plumbing system and requires the addition of constraints from other sources. This lends itself to Bayesian modelling techniques where assumptions are made explicit as priors and uncertainties in retrieved parameters can be comprehensibly modelled

  1. Fifty years of mapping the Balkan flora for Atlas Florae Europaeae

    Directory of Open Access Journals (Sweden)

    Uotila Pertti

    2017-10-01

    Full Text Available Atlas Florae Europaeae (AFE, a programme for mapping the distribution of vascular plants in Europe, was launched in 1965 as a collaborative effort between European botanists. A historical review of the mapping for AFE in the Balkan countries, cited in the last volume (16 from 2013 as Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Former Yugoslav Republic (F. Y. R. of Macedonia, Greece, Kosovo, Montenegro, Serbia, Slovenia, and Turkey (European part, is presented and achievements and problems discussed. The special challenges facing mapping of the Balkan area during the past 50 years include the extremely rich flora, diverse and mountainous relief, political and economic difficulties, inaccessibility of available data, and scarcity of botanists contributing and collecting data for mapping.

  2. [Fifty years of population growth and absorbing manual labor in Brazil, 1950-2000].

    Science.gov (United States)

    Paiva, P D

    1986-01-01

    The economically active population has grown rapidly in Brazil, resulting either from population growth or increased female participation in the work force. This rhythm of growth will continue at least until the end of this century. The authors suggest that the impact of the recent decline in fertility will be moderate and will only affect the younger age groups. Despite the rapid growth of employment in the processing industry, the relative size of the so-called informal sector has remained stable since 1950. It is further predicted that, given the economically active population's rate of growth and the decrease in employment in agriculture, there will be a great demand for urban employment in the next 20 years.

  3. Legend and legacy: Fifty years of defense production at the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, M.S.

    1992-09-01

    Today, the Hanford Site is engaged in the largest waste cleanup effort ever undertaken in human history. That in itself makes the endeavor historic and unique. The Hanford Site has been designated the ``flagship`` of Department of Energy (DOE) waste remediation endeavors. And, just as the wartime Hanford Project remains unmatched in history, no counterpart exists for the current waste cleanup enterprise. This report provides a summary of the extensive historical record, however, which does give a partial road map. The science of environmental monitoring pioneered at the Hanford Site, and records of this type are the most complete of any in the world, from private companies or public agencies, for the early years of Site operations. The Hanford Site was unique for establishing a detailed, scientific, and multi-faceted environmental monitoring program.

  4. Cognitive function fifty-six years after surgical treatment of temporal lobe epilepsy: A case study

    Directory of Open Access Journals (Sweden)

    Sarah Jane Banks

    2014-01-01

    Our investigation at 56 postoperative years focused on cognitive skills, with some emphasis on learning and memory; a clinical examination was also performed, and the anatomical extent of the resection was determined on 3-Tesla magnetic resonance imaging. Four age- and IQ-appropriate women were tested as healthy control subjects. The patient showed material-specific impairments in language and verbal memory compared with the control subjects and also compared with her own earlier performance, but her performance on other cognitive tasks did not differ from that of the control subjects. Thus, her specific deficits had worsened over time, and she was also impaired compared with healthy individuals of her age, but her deficits remained confined to the verbal sphere, consistent with her temporal lobe seizure focus and surgery.

  5. Fifty years of computer analysis in chest imaging: rule-based, machine learning, deep learning.

    Science.gov (United States)

    van Ginneken, Bram

    2017-03-01

    Half a century ago, the term "computer-aided diagnosis" (CAD) was introduced in the scientific literature. Pulmonary imaging, with chest radiography and computed tomography, has always been one of the focus areas in this field. In this study, I describe how machine learning became the dominant technology for tackling CAD in the lungs, generally producing better results than do classical rule-based approaches, and how the field is now rapidly changing: in the last few years, we have seen how even better results can be obtained with deep learning. The key differences among rule-based processing, machine learning, and deep learning are summarized and illustrated for various applications of CAD in the chest.

  6. Legend and legacy: Fifty years of defense production at the Hanford Site

    International Nuclear Information System (INIS)

    Gerber, M.S.

    1992-09-01

    Today, the Hanford Site is engaged in the largest waste cleanup effort ever undertaken in human history. That in itself makes the endeavor historic and unique. The Hanford Site has been designated the ''flagship'' of Department of Energy (DOE) waste remediation endeavors. And, just as the wartime Hanford Project remains unmatched in history, no counterpart exists for the current waste cleanup enterprise. This report provides a summary of the extensive historical record, however, which does give a partial road map. The science of environmental monitoring pioneered at the Hanford Site, and records of this type are the most complete of any in the world, from private companies or public agencies, for the early years of Site operations. The Hanford Site was unique for establishing a detailed, scientific, and multi-faceted environmental monitoring program

  7. [Fifty years of psychiatry at the interface between psyche and soma: a SWOT analysis].

    Science.gov (United States)

    van Houdenhove, B; Luyten, P

    2008-01-01

    During the past 50 years the border area between psychiatry and somatic medicine has undergone remarkable changes. Theories have become better-founded, both psychologically and neurobiologically, research has become more sophisticated, and liaison-psychiatrists and health psychiatrist/behavioural medicine psychologists have played an increasingly active role in this domain. At the beginning of the 21st century modern psychosomatic medicine is facing new challenges; these include how to create a workable diagnostic classification system, how to instruct and educate both health professionals and lay-persons to an adequate level, how to utilize innovative research paradigms without having recourse to reductionism and how to implement in medical practice treatments that are geared to the needs of the individual patient.

  8. One hundred and fifty years of sprint and distance running – Past trends and future prospects

    Science.gov (United States)

    Weiss, Martin; Newman, Alexandra; Whitmore, Ceri; Weiss, Stephan

    2016-01-01

    Abstract Sprint and distance running have experienced remarkable performance improvements over the past century. Attempts to forecast running performances share an almost similarly long history but have relied so far on relatively short data series. Here, we compile a comprehensive set of season-best performances for eight Olympically contested running events. With this data set, we conduct (1) an exponential time series analysis and (2) a power-law experience curve analysis to quantify the rate of past performance improvements and to forecast future performances until the year 2100. We find that the sprint and distance running performances of women and men improve exponentially with time and converge at yearly rates of 4% ± 3% and 2% ± 2%, respectively, towards their asymptotic limits. Running performances can also be modelled with the experience curve approach, yielding learning rates of 3% ± 1% and 6% ± 2% for the women's and men's events, respectively. Long-term trends suggest that: (1) women will continue to run 10–20% slower than men, (2) 9.50 s over 100 m dash may only be broken at the end of this century and (3) several middle- and long-distance records may be broken within the next two to three decades. The prospects of witnessing a sub-2 hour marathon before 2100 remain inconclusive. Our results should be interpreted cautiously as forecasting human behaviour is intrinsically uncertain. The future season-best sprint and distance running performances will continue to scatter around the trends identified here and may yield unexpected improvements of standing world records. PMID:26088705

  9. Fifty years dynamics of Russian forests: Impacts on the earth system

    Science.gov (United States)

    Shvidenko, Anatoly; Schepaschenko, Dmitry; Kraxner, Florian

    2015-04-01

    The paper presents a succinct history of Russian forests during the time period of 1960-2010 and reanalysis of their impacts on global carbon and nitrogen cycles. We present dynamics of land cover change (including major categories of forest land) and biometric characteristics of forests (species composition, age structure, growing stock volume etc.) based on reconciling all relevant information (data of forest and land inventories, official forest management statistics, multi-sensor remote sensing products, data of forest pathological monitoring etc.). Completeness and reliability of background information was different during the period of the study. Forest inventory data and official statistics were partially modified based on relevant auxiliary information and used for 1960-2000. The analysis for 2001-2010 was provided with a crucial use of multi-sensor remote sensing data. For this last period a hybrid forest mask was developed at resolution of 230m by integration of 8 remote sensing products and using geographical weighted regression and data of crowdsourcing. During the considered 50 years forested areas of Russia substantially increased by middle of 1990s and slightly declined (at about 5%) after. Indicators needed for assessment of carbon and nitrogen cycles of forest ecosystems were defined for the entire period (aggregated estimates by decades for 1960-2000 and yearly for 2001-2010) based on unified methodology with some peculiarities following from availability of information. Major results were obtained by landscape-ecosystem method that uses as comprehensive as possible empirical and semi-empirical information on ecosystems and landscapes in form of an Integrated Land Information System and complimentary combines pool- and flux-based methods. We discuss and quantify major drivers of forest cover change (socio-economic, environmental and climatic) including forest management (harvest, reforestation and afforestation), impacts of seasonal weather on

  10. Fifty-year trends in a box turtle population in Maryland

    Science.gov (United States)

    Hall, R.J.; Henry, P.F.P.; Bunck, C.M.

    1999-01-01

    A survey conducted in 1995 investigated long term declines reported in a population of box turtles Terrapene Carolina monitored each decade since 1945 in bottomland hardwood forest at the Patuxent Wildlife Research Center, Maryland. Methods duplicated past surveys in most respects, but were supplemented by radiotelemetry and a survey of dominant vegetation. Seventy different turtles were found on the 11.8 ha study area, a decline of >75% since peak populations were recorded in 1955. Searchers were less efficient in 1995 than in 1945-1975 for a variety of possible reasons. Among turtles recorded, approximately equal numbers persisted from each of the past five decades, with some individuals surviving >70 years. A sex ratio strongly favoring males was first recorded in 1975 and continued in 1995, but juveniles and subadults were found in greater proportion in 1995 than in any other survey. Six of nine radio-marked turtles left the bottomland study area and migrated to the adjoining bluffs to hibernate, suggesting more extensive movements and perhaps less stable home ranges than formerly thought. Age structure of trees indicated a gradual change to more shade-tolerant species. Examination of rates of change from survey data suggested that major losses probably resulted from changes in hydrology that exacerbated flooding in 1972, with recovery only beginning in 1995 and perhaps limited both by repeated flood events and successional changes in the forest. Slow recovery from losses may indicate that populations of the species would respond poorly to exploitation.

  11. Fifty years of population growth and absorption of labor in Brazil: from 1950 to 2000.

    Science.gov (United States)

    Paiva, P D

    1997-01-01

    For a long time, the Brazilian population has grown at a relatively high rate, and only recently has the process of demographic transition intensified in the country. While the associated decline in fertility could result in a future decline in the size of the working-age population, it could also lead to an increase in female participation in the labor market. Brazil's economy is performing well, with gross domestic product (GDP) growing at an average annual rate of 7.1% during 1947-80. Marked growth in industrial employment opportunities has accompanied this growth in GDP. The size of the informal sector, however, has not decreased in similar proportion, while the 1981-83 economic crisis caused urban employment levels to drop, especially in industry and construction. Moreover, the level of rural-urban migration has increased and the agricultural employment index has fallen. The author evaluates past growth trends of the Economically Active Population (EAP) and of employment in Brazil, and assesses the potential growth of the labor force until the year 2000.

  12. Fifty years old, and still going strong: Transmission electron optical studies of materials

    International Nuclear Information System (INIS)

    Brown, L.M.

    2008-01-01

    Highlights in the history of transmission electron microscopy and scanning transmission electron microscopy include the introduction of diffraction contrast, resolution of periodic lattices by phase contrast and incoherent imaging via the high-angle annular dark-field detector. Convergent-beam electron diffraction and analytical electron microscopy, especially the application of energy-dispersive X-ray and electron energy-loss spectrometry, have provided structural and chemical information in addition to strain contrast from lattice defects. From the outset, novel specimen stages and improvements to aid the operator enhanced the electron-optical engineering provided by the instrument makers. The spatial resolution achieved was mainly determined by the way the instrument was used, and not by the basic resolution limit set by the electron optics. However, the application of computer controlled correction of spherical (and higher order) aberration has resulted in a new generation of instruments capable of sub-Angstrom point-to-point resolution. This improved performance, combined with electron energy-loss spectrometry, promises genuine three-dimensional determination of atomic and electronic structure: an indispensable weapon in the battle to fabricate and control useful nanostructures. The uncertainty principle now fundamentally restricts some of the observations one can make, but much more technical development over the next decades must occur before one can say that the techniques of electron-optical imaging of material structure have reached their fundamental limitations. One can expect remarkable progress over the next few years

  13. Science that connects the past and the future. Fifty years of 14C dating

    International Nuclear Information System (INIS)

    Imamura, M.

    2006-01-01

    Major contribution of radiochemistry in archaeological sciences is the dating which provides the most essential information in studies of prehistory. In particular the method of 14 C dating revolutionized the theory of civilization in the world. In this talk I will review 50 years of 14 C dating, techniques and applications, and then the possibilities in contemporary world. The technical developments are featured by ultra-sensitive method of accelerator mass spectrometry in 1977 and its developments, and an introduction of international calibration datasets for 14 C dates started in 1986. Both contributed greatly to improvements in versatility and precision for dating. As for the applications, several interesting topics are reviewed such as the origin of agriculture and its propagation in the western world, the oldest pottery production in Japanese archipelago and its relation to world climate, paddy-rice agriculture and its propagation in Japanese archipelago. Since 14 C studies in nature is also well known as key information on carbon dynamics in earth's surface, it may be said that 14 C play an extraordinary role in understanding our past, present and the future. (author)

  14. THE CLIMATE OF LAGO MAGGIORE AREA DURING THE LAST FIFTY YEARS

    Directory of Open Access Journals (Sweden)

    Angelo Rolla

    2006-09-01

    Full Text Available Data collected in over 50 years' activity at the C.N.R. meteorological station of Pallanza were analysed to see whether any changes have taken place in some climatic elements and to quantify the extent of such changes. A statistical analysis of the respective historical series was performed on nine meteorological parameters (solar radiation, insolation, air temperature, atmospheric pressure, humidity, cloud cover, precipitation, evaporation and wind, and on two other strictly limnological features: the level of Lago Maggiore and its water temperature at six different depths. In particular, we evaluated the means and the extremes (maxima and minima on an annual, seasonal, monthly and daily level, with the results presented uniformly for all the parameters, also in graphic form. We especially highlighted the trend lines, even though they were not always statistically significant owing to the extreme variability of the meteorological data; in the absence of statistical validity, their significance is an approximate indication of their increasing or decreasing trend. Results showed that insolation, air temperature and atmospheric pressure had increased markedly over time, at least on an annual level, with the trends for solar radiation, humidity and cloud cover also showing an increase, though very slight. Evaporation and wind showed a steady, marked decrease, while precipitation and lake level were essentially stable. Water temperature showed a more varied picture, with the temperature of the topmost levels (to a depth of 10 m continuing to increase.

  15. Fifty years of HgCdTe at Texas Instruments and beyond

    Science.gov (United States)

    Kinch, Michael A.

    2009-05-01

    Work on HgCdTe began at Texas Instruments in the early 1960s, and continued through 1997 when TI's defense business was sold first to Raytheon, and subsequently in 1998 to DRS Technologies. This presentation traces the history of HgCdTe's evolution throughout this timeframe to the present day, as viewed through the eyes of the author and several of his TI contemporaries who have survived the experience. The materials technology will be traced from the early days of bulk growth by the solid state recrystalization technique, through the traveling heater method of growth, to liquid phase epitaxy from large Te-rich melts, to vapor phase growth by molecular beam epitaxy and metal organic chemical vapor deposition. The evolution of detector device architectures at TI over the years will be discussed, from the early, successful days of photoconductors and the Common Module System, through the somewhat problematic and relatively unsuccessful foray into charge coupled and charge injection devices for 2nd generation FPAs for the Javelin program, to the outstandingly successful development of the vertically integrated photodiode (VIP) and high density VIP FPA architectures for mono-color and multi-color 3rd generation systems. The versatile, and unique nature of this infrared semiconductor materials system will be highlighted by reference to current work at DRS Technologies into electron avalanche photodiodes (EAPDs), for use in active/passive IR systems, and high operating temperature (HOT) detectors, which threaten to eventually offer BLIP photon detection at uncooled operating temperatures, over the whole IR spectrum from 1 to 12um.

  16. Comparing Socialist and Post-Socialist Television Culture. Fifty Years of Television in Croatia

    Directory of Open Access Journals (Sweden)

    Zrinjka Peruško

    2014-06-01

    Full Text Available This article builds a theoretical model for comparative analysis of media culture based on the notion of genre, and applies it to a comparative analysis of television as a cultural form in socialist and post-socialist Croatia. The paper explores how the shares and generic composition of program modes of information, entertainment and fiction change in time, and how the contribution of different genres to program flow and modes varies with the changes of political, economic and technological context. Longitudinal trends in television flows are comparatively evaluated in relation to trends in genre developments in Europe and their relationship to the changes in the cultural role of television. The results show a decrease in the information and an increase in the fiction mode between socialism and democracy, with some similarities of the Croatian and western television culture in relation to genre and mode composition and flow, albeit with a belated introduction of neo television genres. Notwithstanding the limited freedom of expression and ideological content, which necessarily influenced socialist media culture, television as a cultural form in Croatia developed in concert with the global program flows. The article is based on original content analysis of television schedules where the unit of analysis is a televisions program listing. The analogue television universe is represented by longitudinal data for 1959, 1969, 1979, 1989, 1999, and 2009. The stratified systematic sample (N=3934 for each chosen year consists of two constructed weeks from a universe of all listed programs broadcast on all free to air television channels with a national reach license.

  17. Homo cyborg: fifty years old Homo Ciborg: Cincuenta años después

    Directory of Open Access Journals (Sweden)

    Chris Hables Gray

    2011-12-01

    Full Text Available While the term “cyborg” is only 50 years old, the process that has produced cyborgization is much older: the evolution of the human. Humans have evolved to modify ourselves and our environment, especially through evolving culture and the technologies it creates. Culture is part of nature. Today’s mundane i-cyborgs, military drones, intimate human-machine merging and genetic engineering are a result of this; which in turn produce feelings of uncanniness, hubris, and fear. Contemporary politics must take this complex dynamic into account if we are to secure a sustainable, survivable, future for ourselves and our descendents. Social experiments such as Burning Man are a prefiguration of the kinds of (self conscious techno-social creativity needed.Mientras la terminología “ciborg” tiene apenas 50 años, son mucho más antiguos los procesos de “ciborgización”: la evolución humana. Los humanos evolucionaron para modificar su entorno y a sí mismos, especialmente a través de la cultura y las tecnologías. La cultura es parte de la naturaleza. De ella resultan los i-ciborgs mundanos de la actualidad,  los aviones militares no tripulados, la fusión íntima humano-máquina y la ingeniería genética: lo que a su vez produce sensaciones de inquietud, arrogancia y miedo. La política contemporánea debe de considerar si estamos asegurando un futuro sostenible y vivible para nuestros descendientes. Algunos experimentos sociales como el Burning Man son una prefiguración de esta necesidad creativa por la concienciación tecno-social.

  18. Ocean climate coupling in the tropical Pacific Ocean over the past fifty years: implications and feedbacks

    International Nuclear Information System (INIS)

    Wang, Xiujun; Murtugudde, Ragu; Busalacchi, Antonio J.

    2007-01-01

    Full text: The tropical Pacific plays an important role in climate because of its significant air-sea exchanges of heat, freshwater, and carbon dioxide (C02), and because of its direct linkage to climate variability. There are two dominant modes of climate variability in the Tropics: the El Nino-Southern Oscillation (ENSO) phenomenon and the Pacific Decadal Oscillation (PDO). There has been strong evidence of ENSO and PDO impacts on tropical Pacific physics and biogeochemistry, including heat content, ocean circulation (McPhaden and Zhang 2002), and carbon fluxes (Feely ef al. 2006; Wang ef al. 2006). In this study, we apply a basin-scale ocean circulation-ecosystem-carbon model (Wang ef al. 2006) to study the responses of the tropical Pacific ecosystem, biogeochemistry and carbon cycle to climate forcing over the past 50 years. The model produces strong spatial and temporal variability in surface nutrient concentration, phytoplankton biomass, carbon uptake, and sea-to-air C02 flux, which are largely associated with the ENSO phenomenon. In particular, the size of the tropical Pacific C02 source is large during the ENSO cold phase but small during the ENSO warm phase. There are significant decadal variations in tropical Pacific carbon fluxes, reflecting physical and biogeochemical changes associated with the 1977 and 1997/98 PDO shifts. The 1977 regime shift caused 1 0 C warming in sea surface temperature and -50% reduction in surface iron concentration in the Niho3.4 area, leading to decreased biological activity. While there is a large decrease in phytoplankton growth and biomass, reduction in carbon uptake is smaller than expected, due to phytoplankton photoadaption, which increases the carbon to chlorophyll ratio in the upper euphotic zone and enhances sub-surface production. Photoadaption also results in clearer water near the surface, leading to less heating near the ocean surface and allowing more solar radiation to penetrate the subsurface. Our studies

  19. The big and little of fifty years of Moessbauer spectroscopy at Argonne

    International Nuclear Information System (INIS)

    Westfall, C.

    2005-01-01

    Using radioactive materials obtained by chance, a turntable employing gears from Heidelberg's mechanical toy shops, and other minimal equipment available in post World War II Germany, in 1959 Rudolf Moessbauer confirmed his suspicion that his graduate research had yielded ground-breaking results. He published his conclusion: an atomic nucleus in a crystal undergoes negligible recoil when it emits a low energy gamma ray and provides the entire energy to the gamma ray. In the beginning Moessbauer's news might have been dismissed. As Argonne nuclear physicist Gilbert Perlow noted: ''Everybody knew that nuclei were supposed to recoil when emitting gamma rays--people made those measurements every day''. If any such effect existed, why had no one noticed it before? The notion that some nuclei would not recoil was ''completely crazy'', in the words of the eminent University of Illinois condensed matter physicist Frederich Seitz. Intrigued, however, nuclear physicists as well as condensed matter (or solid state) physicists in various locations--but particularly at the Atomic Energy Research Establishment at Harwell in Britain and at Argonne and Los Alamos in the U.S.--found themselves pondering the Moessbauer spectra with its nuclear and solid state properties starting in late 1959. After an exciting year during which Moessbauer's ideas were confirmed and extended, the physics community concluded that Moessbauer was right. Moessbauer won the Nobel Prize for his work in 1961. In the 1960s and 1970s Argonne physicists produced an increasingly clear picture of the properties of matter using the spectroscopy ushered in by Moessbauer. The scale of this traditional Moessbauer spectroscopy, which required a radioactive source and other simple equipment, began quite modestly by Argonne standards. For example Argonne hosted traditional Moessbauer spectroscopy research using mostly existing equipment in the early days and equipment that cost $100,000 by the 1970s alongside work at

  20. The big and little of fifty years of Moessbauer spectroscopy at Argonne.

    Energy Technology Data Exchange (ETDEWEB)

    Westfall, C.

    2005-09-20

    Using radioactive materials obtained by chance, a turntable employing gears from Heidelberg's mechanical toy shops, and other minimal equipment available in post World War II Germany, in 1959 Rudolf Moessbauer confirmed his suspicion that his graduate research had yielded ground-breaking results. He published his conclusion: an atomic nucleus in a crystal undergoes negligible recoil when it emits a low energy gamma ray and provides the entire energy to the gamma ray. In the beginning Moessbauer's news might have been dismissed. As Argonne nuclear physicist Gilbert Perlow noted: ''Everybody knew that nuclei were supposed to recoil when emitting gamma rays--people made those measurements every day''. If any such effect existed, why had no one noticed it before? The notion that some nuclei would not recoil was ''completely crazy'', in the words of the eminent University of Illinois condensed matter physicist Frederich Seitz. Intrigued, however, nuclear physicists as well as condensed matter (or solid state) physicists in various locations--but particularly at the Atomic Energy Research Establishment at Harwell in Britain and at Argonne and Los Alamos in the U.S.--found themselves pondering the Moessbauer spectra with its nuclear and solid state properties starting in late 1959. After an exciting year during which Moessbauer's ideas were confirmed and extended, the physics community concluded that Moessbauer was right. Moessbauer won the Nobel Prize for his work in 1961. In the 1960s and 1970s Argonne physicists produced an increasingly clear picture of the properties of matter using the spectroscopy ushered in by Moessbauer. The scale of this traditional Moessbauer spectroscopy, which required a radioactive source and other simple equipment, began quite modestly by Argonne standards. For example Argonne hosted traditional Moessbauer spectroscopy research using mostly existing equipment in the early days and

  1. [Fifty years of the Polish School of Medicine at the University of Edinburgh (1941-1991)].

    Science.gov (United States)

    Tomaszewski, W

    1994-01-01

    The Polish School of Medicine at the University of Edinburgh started in 1941 on the initiative of the University. It was destined for soldier-students in the Polish Forces in Great Britain. This academic institution, unique in the history of universities, was a joint Scottish-Polish enterprise. An Agreement was concluded between the Polish Government in London and the University of Edinburgh. The School was an independent Polish academic institution and, at the same time, an integral part of the University of Edinburgh. The students matriculated at the University. The University provided all the laboratory and clinical facilities necessary for teaching. Due to a lack of Polish professors for some chairs a few of them were held by Scottish professors. Attached to them were Polish lecturers but the examinations were then held in English. The diploma, originally valid only in Poland, became recognised in Great Britain following an Act of Parliament in 1947. There were 337 students, a number of them women. 227 obtained the degree M.B., Ch.B. The war ended in 1945. The School continued up till 1949. Poland was not free. The Nazi occupation of Poland was replaced by Soviet domination which was to last for over 40 years. Only 22 of the graduates returned home, about 100 settled in G. Britain, another 100 dispersed world wide. The "magnanimous gesture" of the University of Edinburgh was thereafter remembered with gratitude by the members of the Polish School. In 1961, on the occasion of the 20th anniversary of the School, the first reunion of the graduates was organised in Birmingham for those settled in Gr. Britain. The success of the reunion prompted decision on organising annual "English" gatherings of the Polish graduates in Gr. Britain. The first world reunion of the graduates took place in Edinburgh in 1966, attracting a large number of participants on this occasion of the 25th anniversary of the School. That immensely successful anniversary of the Polish School

  2. Normalization Fifty Years Beyond

    DEFF Research Database (Denmark)

    Bonfils, Inge Storgaard; Tøssebro, Jan; Teittinen, Antti

    2012-01-01

    toward larger group homes and congregations, inequality across municipalities, marketization, and new public management, but also an increasing emphasis on consumer rights and the use of the personal assistance scheme in services for people with ID. The authors conclude that diverging trends coexist...

  3. Florence Richardson Wyckoff (1905-1997), Fifty Years of Grassroots Social ActivismVolume III: Watsonville Years 1960-1985

    OpenAIRE

    Wyckoff, Florence Richardson; Jarrell, Randall

    1990-01-01

    Florence Wyckoff's three-volume oral history documents her remarkable, lifelong work as a social activist, during which she has become nationally recognized as an advocate of migrant families and children. From the depression years through the 1970s, she pursued grassroots, democratic, community-building efforts in the service of improving public health standards and providing health care, education, and housing for migrant families. Major legislative milestones in her career of advocacy were...

  4. From conditioning to learning communities: implications of fifty years of research in e-learning interaction design

    Directory of Open Access Journals (Sweden)

    Andrew Ravenscroft

    2003-12-01

    Full Text Available This paper will consider e-learning in terms of the underlying learning processes and interactions that are stimulated, supported or favoured by new media and the contexts or communities in which it is used. We will review and critique a selection of research and development from the past fifty years that has linked pedagogical and learning theory to the design of innovative e-learning systems and activities, and discuss their implications. It will include approaches that are, essentially, behaviourist (Skinner and Gagné, cognitivist (Pask, Piaget and Papert, situated (Lave, Wenger and Seely-Brown, socioconstructivist (Vygotsky, socio-cultural (Nardi and Engestrom and community-based (Wenger and Preece. Emerging from this review is the argument that effective elearning usually requires, or involves, high-quality educational discourse, that leads to, at the least, improved knowledge, and at the best, conceptual development and improved understanding. To achieve this I argue that we need to adopt a more holistic approach to design that synthesizes features of the included approaches, leading to a framework that emphasizes the relationships between cognitive changes, dialogue processes and the communities, or contexts for e-learning.

  5. An Ode to Stuart Hall's "The Supply of Demand": The Case of Post-Secondary Education in Ontario Fifty Years Later

    Science.gov (United States)

    FitzGerald Murphy, Maggie

    2016-01-01

    Despite the fact that over fifty years have passed since its publication, Stuart Hall's article "The Supply of Demand" (1960), is remarkably relevant today. The central message that society must not be blinded by "prosperity" such that it no longer envisions and demands a better world is especially pertinent in light of the…

  6. Deutsches Atomforum turns fifty

    International Nuclear Information System (INIS)

    Geisler, Maja

    2009-01-01

    Fifty years ago, the Deutsches Atomforum e. V. was founded to promote the peaceful uses of nuclear power in Germany. On July 1, 2009, the organization celebrated its fiftieth birthday in Berlin. The anniversary was celebrated in the Berlin electricity plant, Germany's oldest existing building for commercial electricity generation. DAtF President Dr. Walter Hohlefelder welcomed some 200 high-ranking guests from politics, industry, and from the nuclear community, above all, the Chancellor of the Federal Republic of Germany, Dr. Angela Merkel, and, as keynote speaker, Professor Dr. Arnulf Baring. (orig.)

  7. Fifty years ago, the black coal mine Barsinghausen was shut down; Vor 50 Jahren wurde das Steinkohlenbergwerk Barsinghausen stillgelegt

    Energy Technology Data Exchange (ETDEWEB)

    Boden, Konrad

    2008-09-09

    In the year 1957, the black coal mine Barsinghausen of the former Preussag AG was shut down. Under this aspect, the author of the contribution under consideration recalls this event. Substantial aspects of this contribution are: (a) The mine in the year 1955; (b) How did it come to the shutdown? (c) Reactions in the publicity; (d) Settlement of alternative industry; (e) Works council; (f) Social plan; (g) Where is the staff?.

  8. An Interview with Joe McMann: Lessons Learned from Fifty Years of Observing Hardware and Human Behavior

    Science.gov (United States)

    McMann, Joe

    2011-01-01

    Pica Kahn conducted "An Interview with Joe McMann: Lessons Learned in Human and Hardware Behavior" on August 16, 2011. With more than 40 years of experience in the aerospace industry, McMann has gained a wealth of knowledge. This presentation focused on lessons learned in human and hardware behavior. During his many years in the industry, McMann observed that the hardware development process was intertwined with human influences, which impacted the outcome of the product.

  9. 'Suddenly the First Fifty Years of My Life Made Sense': Experiences of Older People with Autism

    Science.gov (United States)

    Hickey, Aoife; Crabtree, Jason; Stott, Joshua

    2018-01-01

    Research on the experience of growing older with autism is very limited. In this study, 13 people with autism aged over 50 years participated in semi-structured interviews about their experiences of diagnosis, social support and getting older. Interviews were analysed using thematic analysis. Three overarching themes were generated: difference,…

  10. Oak Ridge National Laboratory [ORNL] Review, Vol. 25, Nos. 3 and 4, 1992 [The First Fifty Years

    Science.gov (United States)

    Krause, C.(ed.)

    1992-01-01

    In observation of the 50th anniversary of Oak Ridge National Laboratory, this special double issue of the Review contains a history of the Laboratory, complete with photographs, drawings, and short accompanying articles. Table of contents include: Wartime Laboratory; High-flux Years; Accelerating Projects; Olympian Feats; Balancing Act; Responding to Social Needs; Energy Technologies; Diversity and Sharing; Global Outreach; Epilogue

  11. The Meta-Analysis of Clinical Judgment Project: Fifty-Six Years of Accumulated Research on Clinical Versus Statistical Prediction

    Science.gov (United States)

    Aegisdottir, Stefania; White, Michael J.; Spengler, Paul M.; Maugherman, Alan S.; Anderson, Linda A.; Cook, Robert S.; Nichols, Cassandra N.; Lampropoulos, Georgios K.; Walker, Blain S.; Cohen, Genna; Rush, Jeffrey D.

    2006-01-01

    Clinical predictions made by mental health practitioners are compared with those using statistical approaches. Sixty-seven studies were identified from a comprehensive search of 56 years of research; 92 effect sizes were derived from these studies. The overall effect of clinical versus statistical prediction showed a somewhat greater accuracy for…

  12. Rhode Island hurricanes and tropical storms: A fifty-six year summary 1936-1991. Technical memo

    International Nuclear Information System (INIS)

    Vallee, D.R.

    1993-03-01

    The paper was compiled to provide a general overview of all tropical cyclone activity near Rhode Island since 1936. The year of 1936 is arbitrary, chosen mainly to include a 'not so well known' system prior to the well documented Great New England Hurricane of 1938. Thirty-one such storms have affected the state in the past 56 years, either making landfall along the coast of southern New England, or passing close enough over the offshore waters to spread tropical storm or hurricane force conditions into the area. The intensities of these systems have ranged from weak, disorganized tropical storms to full fledged major hurricanes. The one feature common to almost all of the storms was a rapid acceleration toward Rhode Island, which greatly reduced the time to prepare and evacuate

  13. Pile burning creates a fifty-year legacy of openings in regenerating lodgepole pine forests in Colorado

    Science.gov (United States)

    Charles C. Rhoades; Paula J. Fornwalt

    2015-01-01

    Pile burning is a common means of disposing the woody residues of logging and for post-harvest site preparation operations, in spite of the practice’s potential negative effects. To examine the long-term implications of this practice we established a 50-year sequence of pile burns within recovering clear cuts in lodgepole pine forests. We compared tree, shrub and...

  14. Journal of Limnology Vol. 65 (Suppl. 1): The climate of Lago Maggiore area during the last fifty years

    OpenAIRE

    Giussani, Gianluigi; Bertoni, Roberto

    2006-01-01

    Data collected in over 50 years' activity at the C.N.R. meteorological station of Pallanza were analysed to see whether any changes have taken place in some climatic elements and to quantify the extent of such changes. A statistical analysis of the respective historical series was performed on nine meteorological parameters (solar radiation, insolation, air temperature, atmospheric pressure, humidity, cloud cover, precipitation, evaporation and wind), and on two other strictly limnological fe...

  15. Proceedings of the International Symposium on Advances in Nuclear Physics. Fifty Years of Institutional Physics Research in Romania

    International Nuclear Information System (INIS)

    Poenaru, Dorin; Stoica, Sabin

    2000-01-01

    This Symposium was devoted to the cerebration of 50 years of Institutional Physics Research in Romania. The inaugural talk was given by professor W. Greiner on development in fission, fusion, cluster radioactivity and the extension of the periodic system of elements. Seven divisions followed on the items: super heavy nuclei (4 talks); new fission modes (4 talks); astrophysics and cosmic rays (5 talks); particle and high energy physics (6 talks); hadronic matter (6 talks); nuclear structure and reactions (13 talks); atomic physics (4 talks); applications and history. Many of these talks highlighted the substantial Romanian contributions to the scientific achievements in these fields

  16. A vision for the second fifty years of nuclear energy. Vision and strategies; Wizja drugiego piecdziesieciolecia energetyki jadrowej

    Energy Technology Data Exchange (ETDEWEB)

    Hori, M. [International Nuclear Societies Council (Poland)] [and others

    1997-12-31

    The paper is the Polish issue of the report worked out by International Nuclear Societies Council published in 1996. The report contains the experts opinion on development of nuclear energy and applications of radiation techniques and sources worldwide during the next 50 years. The worldwide energy demand prognosis as well as needs of different branches of industry, agriculture, medicine, etc. have been taken into account. The broad spectrum of aspects (safety assurance, economy, environmental impacts) connected with nuclear technology utilization has been also discussed. Transl., 24 refs, 6 figs, 6 tabs.

  17. Suicides in Serbia at the beginning of the 21st century and trends in the past fifty years

    Directory of Open Access Journals (Sweden)

    Penev Goran

    2007-01-01

    Full Text Available In 2006 in Serbia, 1444 persons committed suicide (19.5 per 100.000 population. Compared to the early 50s of the 20th century, the number of suicides has nearly doubled, but there has been a moderate decrease in the last 15 years. Similar, but somewhat more moderate tendencies are noted in the change of the value of the suicide rates. The lowest suicide rates were recorded during the 1950s, around 12 per 100.000, and the highest in the last decade of the 20th century when the rate reached 20 suicides per 100.000 inhabitants. The highest suicide rate is among the elderly, and there is also a noticeable tendency of increase in the share of the elderly in the total number of suicides, which is primarily the consequence of intense demographic aging. With youth, the last thirty years note a decline of both the number of suicides and the value of the suicide rates. The number of young people aged 15-24 who have committed suicide in 2006 is less than half of the number from 1971 (decreased from 150 to 66, and the values of suicide rates are also significantly low (decreased from 11.5 to 6.9 per 100.000. Despite certain changes in the values of age-specific suicide rates achieved in the last 50 years, their age patterns of suicide mortality can be characterized as stable. Men are dominant among persons who have committed suicide, with double the number of women, and the highest recorded value of the suicide rate of women never surpassed the value of the lowest suicide rate in men. In terms of marital status, the total rate of suicides is highest with widowers then divorced persons, married persons, and lowest rates are with celibates. In all four groups, suicide rates are at least 3 times higher for men. There is also a clear connection between the level of education and suicide rates for both sexes, with the suicide rate decreasing with higher educational level. In terms of total suicide rate, Serbia is currently in the top half of the European list of

  18. Fifty years of violent war deaths from Vietnam to Bosnia: analysis of data from the world health survey programme.

    Science.gov (United States)

    Obermeyer, Ziad; Murray, Christopher J L; Gakidou, Emmanuela

    2008-06-28

    To provide an accurate estimate of violent war deaths. Analysis of survey data on mortality, adjusted for sampling bias and censoring, from nationally representative surveys designed to measure population health. Estimated deaths compared with estimates in database of passive reports. 2002-3 World health surveys, in which information was collected from one respondent per household about sibling deaths, including whether such deaths resulted from war injuries. Estimated deaths from war injuries in 13 countries over 50 years. From 1955 to 2002, data from the surveys indicated an estimated 5.4 million violent war deaths (95% confidence interval 3.0 to 8.7 million) in 13 countries, ranging from 7000 in the Republic of Congo [corrected] to 3.8 million in Vietnam. From 1995 to 2002 survey data indicate 36,000 war deaths annually (16,000 to 71,000) in the 13 countries studied. Data from passive surveillance, however, indicated a figure of only a third of this. On the basis of the relation between world health survey data and passive reports, we estimate 378,000 globalwar deaths annually from 1985-94, the last years for which complete passive surveillance data were available. The use of data on sibling history from peacetime population surveys can retrospectively estimate mortality from war. War causes more deaths than previously estimated, and there is no evidence to support a recent decline in war deaths.

  19. Fifty years on: against the stigmatising myths, taboos and traditions embedded within the Suicide Act 1961 (UK).

    Science.gov (United States)

    Shaw, Julia J A

    2011-06-01

    Although assisted suicide carries a maximum of 14 years imprisonment in England, courts and juries have historically demonstrated a reluctance to convict, most specifically in relation to those travelling abroad to accompany a terminally ill person seeking assisted dying. The possibility of prosecution is still present, however, and there have recently been a number of challenges to the law on assisted dying. During the consultation period of the Coroners and Justice Act 2009 (UK) an amendment was proposed that would have legalised, among other things, assisting suicide overseas. However, it was voted down by peers who believed it to be dangerously radical. In 2008 a multiple sclerosis sufferer requested a clear policy statement, should her partner help her to seek assisted dying abroad in the future. After her application was initially rejected, Mrs Purdy was granted leave to appeal and following a favourable ruling by the House of Lords in 2009, the Director of Public Prosecutions clarified the law on assisted suicide, introducing a Full Code Test which includes the consideration of "public interest factors". Although the new guidelines are not a direct threat to the 50-year-old Suicide Act 1961 (UK), it is clearly an historic development: the latest in a series of high-profile cases and debates which have taken place over the last decade. It is suggested that English law on assisted dying continues to rely on a range of inappropriate concepts, taboos and superstitions, and it is from this perspective that the implications for future legislative reform are addressed.

  20. Summary of Symposium on Cloud Systems, Hurricanes and TRMM: Celebration of Dr. Joanne Simpson's Career, The First Fifty Years

    Science.gov (United States)

    Tao, W.-K.; Adler, R.; Braun, S.; Einaudi, F.; Ferrier, B.; Halverson, J.; Heymsfield, G.; Kummerow, C.; Negri, A.; Kakar, R.; hide

    2000-01-01

    A symposium celebrating the first 50 years of Dr. Joanne Simpson's career took place at the NASA/Goddard Space Flight Center from December 1 - 3, 1999. This symposium consisted of presentations that focused on: historical and personal points of view concerning Dr. Simpson's research career, her interactions with the American Meteorological Society, and her leadership in TRMM; scientific interactions with Dr. Simpson that influenced personal research; research related to observations and modeling of clouds, cloud systems and hurricanes; and research related to the Tropical Rainfall Measuring Mission (TRMM). There were a total of 36 presentations and 103 participants from the US, Japan and Australia. The specific presentations during the symposium are summarized in this paper.

  1. A fifty year record of winter glacier melt events in southern Chile, 38°–42°S

    International Nuclear Information System (INIS)

    Brock, Ben W; Burger, Flavia; Montecinos, Aldo; Rivera, Andrés

    2012-01-01

    Little is known about the frequency and potential mass balance impact of winter glacier melt events. In this study, daily atmospheric temperature soundings from the Puerto Montt radiosonde (41.43°S) are used to reconstruct winter melting events at the glacier equilibrium line altitude in the 38°–42°S region of southern Chile, between 1960 and 2010. The representativeness of the radiosonde temperatures to near-surface glacier temperatures is demonstrated using meteorological records from close to the equilibrium line on two glaciers in the region over five winters. Using a degree-day model we estimate an average of 0.28 m of melt and 21 melt days in the 15 June–15 September period each year, with high inter-annual variability. The majority of melt events are associated with midlatitude migratory high pressure systems crossing Chile and northwesterly flows, that force adiabatic compression and warm advection, respectively. There are no trends in the frequency or magnitude of melt events over the period of record, but the annual frequency of winter melt days shows a significant, although rather weak and probably non-linear, relationship to late winter and early spring values of a multivariate El Niño Southern Oscillation Index (MEI). (letter)

  2. Fifty years of coiled-coils and alpha-helical bundles: a close relationship between sequence and structure.

    Science.gov (United States)

    Parry, David A D; Fraser, R D Bruce; Squire, John M

    2008-09-01

    alpha-Helical coiled coils are remarkable for the diversity of related conformations that they adopt in both fibrous and globular proteins, and for the range of functions that they exhibit. The coiled coils are based on a heptad (7-residue), hendecad (11-residue) or a related quasi-repeat of apolar residues in the sequences of the alpha-helical regions involved. Most of these, however, display one or more sequence discontinuities known as stutters or stammers. The resulting coiled coils vary in length, in the number of chains participating, in the relative polarity of the contributing alpha-helical regions (parallel or antiparallel), and in the pitch length and handedness of the supercoil (left- or right-handed). Functionally, the concept that a coiled coil can act only as a static rod is no longer valid, and the range of roles that these structures have now been shown to exhibit has expanded rapidly in recent years. An important development has been the recognition that the delightful simplicity that exists between sequence and structure, and between structure and function, allows coiled coils with specialized features to be designed de novo.

  3. Fifty Years of Flight Research: An Annotated Bibliography of Technical Publications of NASA Dryden Flight Research Center, 1946-1996

    Science.gov (United States)

    Fisher, David F.

    1999-01-01

    Titles, authors, report numbers, and abstracts are given for more than 2200 unclassified and unrestricted technical reports and papers published from September 1946 to December 1996 by NASA Dryden Flight Research Center and its predecessor organizations. These technical reports and papers describe and give the results of 50 years of flight research performed by the NACA and NASA, from the X-1 and other early X-airplanes, to the X-15, Space Shuttle, X-29 Forward Swept Wing, and X-31 aircraft. Some of the other research airplanes tested were the D-558, phase 1 and 2; M-2, HL-10 and X-24 lifting bodies; Digital Fly-By-Wire and Supercritical Wing F-8; XB-70; YF-12; AFTI F-111 TACT and MAW; F-15 HiDEC; F-18 High Alpha Research Vehicle, and F-18 Systems Research Aircraft. The citations of reports and papers are listed in chronological order, with author and aircraft indices. In addition, in the appendices, citations of 233 contractor reports, more than 200 UCLA Flight System Research Center reports and 25 video tapes are included.

  4. Fifty years of Brazilian Dental Materials Group: scientific contributions of dental materials field evaluated by systematic review

    Science.gov (United States)

    ROSA, Wellington Luiz de Oliveira; SILVA, Tiago Machado; LIMA, Giana da Silveira; SILVA, Adriana Fernandes; PIVA, Evandro

    2016-01-01

    ABSTRACT Objective A systematic review was conducted to analyze Brazilian scientific and technological production related to the dental materials field over the past 50 years. Material and Methods This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (Prisma) statement. Searches were performed until December 2014 in six databases: MedLine (PubMed), Scopus, LILACS, IBECS, BBO, and the Cochrane Library. Additionally, the Brazilian patent database (INPI - Instituto Nacional de Propriedade Industrial) was screened in order to get an overview of Brazilian technological development in the dental materials field. Two reviewers independently analyzed the documents. Only studies and patents related to dental materials were included in this review. Data regarding the material category, dental specialty, number of documents and patents, filiation countries, and the number of citations were tabulated and analyzed in Microsoft Office Excel (Microsoft Corporation, Redmond, Washington, United States). Results A total of 115,806 studies and 53 patents were related to dental materials and were included in this review. Brazil had 8% affiliation in studies related to dental materials, and the majority of the papers published were related to dental implants (1,137 papers), synthetic resins (681 papers), dental cements (440 papers), dental alloys (392 papers) and dental adhesives (361 papers). The Brazilian technological development with patented dental materials was smaller than the scientific production. The most patented type of material was dental alloys (11 patents), followed by dental implants (8 patents) and composite resins (7 patents). Conclusions Dental materials science has had a substantial number of records, demonstrating an important presence in scientific and technological development of dentistry. In addition, it is important to approximate the relationship between academia and industry to expand the technological development in

  5. Fifty years of Brazilian Dental Materials Group: scientific contributions of dental materials field evaluated by systematic review.

    Science.gov (United States)

    Rosa, Wellington Luiz de Oliveira; Silva, Tiago Machado; Lima, Giana da Silveira; Silva, Adriana Fernandes; Piva, Evandro

    2016-01-01

    A systematic review was conducted to analyze Brazilian scientific and technological production related to the dental materials field over the past 50 years. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (Prisma) statement. Searches were performed until December 2014 in six databases: MedLine (PubMed), Scopus, LILACS, IBECS, BBO, and the Cochrane Library. Additionally, the Brazilian patent database (INPI - Instituto Nacional de Propriedade Industrial) was screened in order to get an overview of Brazilian technological development in the dental materials field. Two reviewers independently analyzed the documents. Only studies and patents related to dental materials were included in this review. Data regarding the material category, dental specialty, number of documents and patents, filiation countries, and the number of citations were tabulated and analyzed in Microsoft Office Excel (Microsoft Corporation, Redmond, Washington, United States). A total of 115,806 studies and 53 patents were related to dental materials and were included in this review. Brazil had 8% affiliation in studies related to dental materials, and the majority of the papers published were related to dental implants (1,137 papers), synthetic resins (681 papers), dental cements (440 papers), dental alloys (392 papers) and dental adhesives (361 papers). The Brazilian technological development with patented dental materials was smaller than the scientific production. The most patented type of material was dental alloys (11 patents), followed by dental implants (8 patents) and composite resins (7 patents). Dental materials science has had a substantial number of records, demonstrating an important presence in scientific and technological development of dentistry. In addition, it is important to approximate the relationship between academia and industry to expand the technological development in countries such as Brazil.

  6. Radiation Protection in Slovenia Over the Past Fifty Years (1963-2013) and the Slovenian Society of Radiation Protection

    International Nuclear Information System (INIS)

    Omahen, G.; Krizman, M.J.

    2013-01-01

    The use of the ionizing radiation sources in Slovenia started as early as 1900 when X-ray device was put in operation; the first radioactive source was used two years later. Artificial radioactive sources were introduced from 1954 onwards. The use of radioactive sources in industry started in the middle of the 1950's when industrial radiography was introduced due to strong metal industry in Slovenia. Four nuclear facilities were built in Slovenia: the research reactor TRIGA (1966), the Krško nuclear power plant (1983), the mining and milling uranium complex at Žirovski Vrh (1984) and the low and intermediate level radioactive waste storage (1986). The infrastructure of radiation protection (RP) in the former Yugoslavia was established as late as the first Law on RP was adopted in 1959, the competent authorities were defined and technical support organisations for RP were designated. But the whole infrastructure could not follow the rapid development of nuclear industry and the extent uses of sources. After joining EU, the changes in legislation made a significant shift ahead in radiation protection, as regards the quality of the implementation of radiation protection measures as the intensity of administrative and inspection controls. Slovenian Radiation Protection Society was established in 1981 during the 11th symposium of the Yugoslav Radiation Protection Society. The role of the Slovenian Society for Radiation Protection has never been significant, mostly due to a small critical mass of membership. This is sometimes advantageous since everyone knows each other and can easily come with the problem to be solved. This feature reduces the need for the Society to be active as a formal association. The main role of the Society is the distribution of actual information on RP and related important events.(author)

  7. [Fifty years of residency in Psychiatry at the University of Montreal: relevance and necessity of the Residents' Association].

    Science.gov (United States)

    Thibault, Alexis

    2015-01-01

    In the context of the fiftieth anniversary celebrations of the Département de psychiatrie de l'Université de Montréal, the present article offers to retrace the history of the Psychiatry Resident's Association (ARPUM). Since the Association's activities and demands reflected the concerns of the time, a depiction of the Residency Program and exploration of the historical and administrative context, in each key period, is also undertaken. Multiple psychiatrists from every decade, who were once active members of the Association, were interviewed and asked to describe the Residency Program at their time, with its positive and negative aspects, based on their own personal experience as a resident, but also as a member of the organization. The interviewees were also invited to share their recollections of the various Association's demands, representations, activities and functioning, depending on the issues and periods. Various private and public archives were also used, in order to contextualize the residents' experiences and the Association's work. A brief exploration of the historical and political context that led to the creation of the organization is explained. Training and working conditions of residents at that time are reported, enabling the understanding of the first demands when the group was born. Historical jumps are then proposed, from decades to decades, in order to depict key issues, whether they were academic, clinical or organizational, through which the Association worked, over the evolution of the Residency Program. The internal functioning and its occasional problems throughout the years are also described, as is the role in organizing social and educational events. The Residency Program is in constant mutation, and the Association has played its part in shaping the psychiatric training at the Université de Montréal. Multiple positive and tangible impacts were and are still made possible from the collaborative work between the Département de

  8. The National Institute of Research and Development for Isotopic and Molecular Technologies at Cluj - Napoca - Fifty Years of Experience

    International Nuclear Information System (INIS)

    Vasaru, Gh.

    2000-01-01

    , 15 N, has been separated for the first time by means of a cascade of 4 columns of 10 m total length. Later on a 19 column cascade was used to obtained 13 C. By using the same method the neon isotopes ( 20 Ne, 22 Ne) were separated obtaining enrichment levels of up to 99%. Similar enrichment levels were obtained for 36 Ar, 78 Kr and 86 Kr. A special effort was devoted to enrichment of 15 N, up to 99.8%, with a production yield of 1000 g/year, an isotope largely used in agricultural research and required on external market. The report presents also the separation methodologies for other isotopes. In direct connection with the isotope separation works extremely high precision isotopic and chemical analytical methods for extreme concentration were developed. High performance mass spectrometers were also devised, the institute becoming the most important producer of such equipment in this country. Routine deuterium analyses at Heavy Water plant at Drobeta- Turnu Severin are carried out with high precision mass spectrometers produced at ITIM. Finally, the report presents the works on novel applications of stable isotopes separated or enriched at ITIM

  9. Fifty Years of Matter Waves

    Science.gov (United States)

    Medicus, Heinrich A.

    1974-01-01

    Discusses the origin of de Broglie's concept and its influences on his contemporaries, notably on Einstein, Schrodinger, Elsasser, Davisson, and Thomson. Indicates that the theory served not only as the starting point of quantum mechanics, but also opened new experimental possibilities. Historical inaccuracies are corrected with new material…

  10. Fifty years of pacemaker advancements.

    Science.gov (United States)

    Steinhaus, David

    2008-12-01

    A 1957 power blackout in Minnesota prompted C. Walton Lillehei, MD, a pioneer in open heart surgery, to ask Earl Bakken, the co-founder of Medtronic, Inc., to create a battery-operated pacemaker for pediatric patients. That conversation led to the development of the first external battery-operated pacemaker. That first bulky device is far removed from the tiny implantable computers available to heart patients today. Now, the size of two silver dollars stacked on top of one another, a pacemaker is prescribed for a person whose heart beats too slowly or pauses irregularly. Slightly larger devices have more recently evolved from pacing and regulating the heartbeat to being able to provide therapeutic high voltage shocks when needed to stop runaway fast heart rates, recording heart activity, and other physiologic functions, even resynchronizing the heart's chambers-all while providing information on the patient's condition and device performance to the doctor remotely or in the office.

  11. Cardiac Dose From Tangential Breast Cancer Radiotherapy in the Year 2006

    International Nuclear Information System (INIS)

    Taylor, Carolyn W.; Povall, Julie M.; McGale, Paul; Nisbet, Andrew; Dodwell, David; Smith, Jonathan T.; Darby, Sarah C.

    2008-01-01

    Purpose: To quantify the radiation doses received by the heart and coronary arteries from contemporary tangential breast or chest wall radiotherapy. Methods and Materials: Fifty consecutive patients with left-sided breast cancer and 5 consecutive patients with right-sided breast cancer treated at a large United Kingdom radiotherapy center during the year 2006 were selected. All patients were irradiated with 6- or 8-MV tangential beams to the breast or chest wall. For each dose plan, dose-volume histograms for the heart and left anterior descending (LAD) coronary artery were calculated. For 5 of the left-sided and all 5 right-sided patients, dose-volume histograms for the right and circumflex coronary arteries were also calculated. Detailed spatial assessment of dose to the LAD coronary artery was performed for 3 left-sided patients. Results: For the 50 patients given left-sided irradiation, the average mean (SD) dose was 2.3 (0.7) Gy to the heart and 7.6 (4.5) Gy to the LAD coronary artery, with the distal LAD receiving the highest doses. The right and circumflex coronary arteries received approximately 2 Gy mean dose. Part of the heart received >20 Gy in 22 left-sided patients (44%). For the 5 patients given right-sided irradiation, average mean doses to all cardiac structures were in the range 1.2 to 2 Gy. Conclusions: Heart dose from left-tangential radiotherapy has decreased considerably over the past 40 years, but part of the heart still receives >20 Gy for approximately half of left-sided patients. Cardiac dose for right-sided patients was generally from scattered irradiation alone

  12. Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs.

    Science.gov (United States)

    Andreasen, Nancy C; Pressler, Marcus; Nopoulos, Peg; Miller, Del; Ho, Beng-Choon

    2010-02-01

    A standardized quantitative method for comparing dosages of different drugs is a useful tool for designing clinical trials and for examining the effects of long-term medication side effects such as tardive dyskinesia. Such a method requires establishing dose equivalents. An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study. Regression was used to compare each drug in the experts' charts to chlorpromazine and haloperidol and to create formulas for each relationship. The formulas were solved for chlorpromazine 100 mg and haloperidol 2 mg to derive new chlorpromazine and haloperidol equivalents. The formulas were incorporated into our definition of dose-years such that 100 mg/day of chlorpromazine equivalent or 2 mg/day of haloperidol equivalent taken for 1 year is equal to one dose-year. All comparisons to chlorpromazine and haloperidol were highly linear with R(2) values greater than .9. A power transformation further improved linearity. By deriving a unique formula that converts doses to chlorpromazine or haloperidol equivalents, we can compare otherwise dissimilar drugs. These equivalents can be multiplied by the time an individual has been on a given dose to derive a cumulative value measured in dose-years in the form of (chlorpromazine equivalent in mg) x (time on dose measured in years). After each dose has been converted to dose-years, the results can be summed to provide a cumulative quantitative measure of lifetime exposure. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

  13. Receptor dose and patient dose in radiographic exposures: a 15 year review

    International Nuclear Information System (INIS)

    Peet, D.J.; Tyler, N.; Pryor, M.; Hollaway, P.; Strudley, C.; Leavesley, L.

    2008-01-01

    A patient dose programme has been established locally for the last 15 years across 109 hospitals and 250 X-ray rooms in line with the National Protocol, in conjunction with a programme to look at routine performance of these rooms. Routine performance checks initially looked primarily at film density and AEC performance but with the introduction of Computerised Radiography (CR) across UK hospitals and a revision of recommended procedures in the UK, the emphasis has shifted to assessing receptor dose under AEC control. Results show a wide variation in film density in the early years indicating sub optimal performance and dose. The spread was reduced over later years. The introduction of CR has led to a variety of approaches by the CR companies, X-ray companies and local sites. Receptor doses vary widely as a result. Large variations within hospitals were also observed. The doses over the last 15 years are reviewed and compared against diagnostic reference levels and with the performance of the imaging chain. Results show that patient dose programmes and optimisation strategies were having an impact, but the introduction of CR requires renewed efforts to ensure images and doses are optimised. (author)

  14. Il clima dell'areale del Lago Maggiore durante gli ultimi cinquant'anni (The climate of Lago Maggiore area during the last fifty years)

    OpenAIRE

    Ambrosetti, Walter; Barbanti, Luigi; Rolla, Angelo

    2006-01-01

    Data collected in over 50 years' activity at the C.N.R. meteorological station of Pallanza were analysed to see whether any changes have taken place in some climatic elements and to quantify the extent of such changes. A statistical analysis of the respective historical series was performed on nine meteorological parameters (solar radiation, insolation, air temperature, atmospheric pressure, humidity, cloud cover, precipitation, evaporation and wind), and on two other strictly limnological fe...

  15. Changes in drought tolerance in maize associated with fifty years of breeding for yield in the US Corn Belt [Zea mays L.

    International Nuclear Information System (INIS)

    Campos, H.; Cooper, M.; Edmeades, G.O.; Löffler, C.; Schussler, J.R.; Ibanez, M.

    2006-01-01

    Understanding the changes underlying past breeding progress may help to focus research efforts and accelerate future genetic gains. The major abiotic stress affecting maize production on a worldwide basis is drought. We addressed the improvements in drought tolerance over a 50-year period of hybrid breeding by evaluating, under targeted stress conditions, a set of 18 Pioneer-brand hybrids that had been released during the 1953-2001 period. Stress treatments were designed as overlapping windows of water deficit covering the pre-flowering to late grain filling development stages. Data were collected on grain yield, yield components and anthesis-silking interval (ASI) and were analyzed using a linear mixed model approach. Genetic gain was measured as the slope of the regression of the trait on the year of hybrid release. Significant, positive genetic gains of varying magnitude were observed for grain yield in all windows of stress evaluated. The largest genetic gains for grain yield were observed under conditions of full irrigation and severe flowering stress. ASI and barrenness, especially under stress at flowering, were significantly reduced by selection. Though flowering remains the most susceptible stage to drought in maize, selection has reduced its negative effects and susceptibility during early grain filling is now of similar importance in many modern hybrids. Yield under drought at flowering has more than kept pace with the increase in yield potential because of the emphasis breeders have placed on improved floral synchrony [it

  16. Long-term trends in sodium and chloride in the Mohawk River, New York: the effect of fifty years of road-salt application

    International Nuclear Information System (INIS)

    Godwin, K.S.; Hafner, S.D.; Buff, M.F.

    2003-01-01

    Sodium and chloride have increased in the last 50 years in this river ecosystem. - Ecological studies have demonstrated the adverse effects of road-salt, primarily NaCl, on water quality, flora, and fauna. In this study, we quantified changes in ionic composition and solute flux of water draining the Mohawk River Basin (9103 km 2 ) in New York State, from 1952 to 1998. Using various statistical, graphical, and modeling techniques, we showed that concentrations of Na + and Cl - have increased by 130 and 243%, respectively, while other constituents have decreased or remained constant. The use of de-icing salt on roads within the watershed, which we estimate at 39 kg km -2 day -1 , appears to be the primary mechanism responsible for reported increases, accounting for the increase in NaCl export from 16 to 46 kg km -2 day -1 over the 47-year period. Moreover, despite population decline within this rural upstate watershed, increased environmental stewardship, and The Clean Water Act, concentrations of Na + and Cl - still increased during the 1990s

  17. Fifty-three years' experience with randomized clinical trials of emergency portacaval shunt for bleeding esophageal varices in Cirrhosis: 1958-2011.

    Science.gov (United States)

    Orloff, Marshall J

    2014-02-01

    Emergency treatment of bleeding esophageal varices (BEV) consists mainly of endoscopic and pharmacologic measures, with transjugular intrahepatic portal-systemic shunt (TIPS) performed when bleeding is not controlled. Surgical shunt has been relegated to salvage. At the University of California, San Diego, Medical Center, our group has conducted 10 studies of emergency portacaval shunt (EPCS) during 46 years. To describe 2 randomized clinical trials (RCTs) conducted from 1988 to 2011 in unselected consecutive patients who received emergency treatment for BEV. In RCT No. 1, a total of 211 unselected consecutive patients with cirrhosis and acute BEV were randomized to emergency endoscopic sclerotherapy (EEST) (n=106) or EPCS (n=105). In RCT No. 2, a total of 154 unselected consecutive patients with cirrhosis and acute BEV were randomized to TIPS (n=78) or EPCS (n=76). Diagnostic workup was completed within 6 hours of initial contact, and primary treatment was initiated within 8 to 12 hours. Regular follow-up for up to 10 years was accomplished in 100% of the patients. In RCT No. 1, EEST or EPCS; in RCT No. 2, TIPS or EPCS. The 2 groups were compared with regard to survival, control of bleeding, portal-systemic encephalopathy, and direct cost of care. RESULTS Distribution in Child risk classes was almost identical. One-third of patients were in Child class C. Permanent control of bleeding was achieved by EEST in only 20% of the patients and by TIPS in only 22%. In contrast, EPCS permanently controlled bleeding in 97% and 100% of the patients in RCT No. 2 and RCT No. 1, respectively (Pcases. Recurrent portal-systemic encephalopathy developed in 35% of the patients who underwent EEST and 61% of those who received TIPS. In contrast, portal-systemic encephalopathy occurred in 15% of the patients who received EPCS in RCT No. 1 and 21% of those in RCT No. 2. Direct costs of care were 5 to 7 times greater in the EEST ($168100) and TIPS ($264800) groups than in the EPCS

  18. The 1.3-m Robotically Controlled Telescope (RCT) at Kitt Peak - A Fifty year old dream Realized: Telescope Characteristics, Current Research and Education Progr

    Science.gov (United States)

    Guinan, Edward; Gelderman, Richard; Strolger, Louis-Gregory; Carini, Michael T.; McGruder, Charles, III; Campbell, Rachel; Walter, Donald K.; Davis, Donald R.; Tedesco, Edward F.; Engle, Scott G.

    2011-03-01

    The 1.3 m Robotically Controlled Telescope (RCT) on Kitt Peak has a rich history, including its role as a prototype for remotely controlled telescopes during the 1960s. As such, the RCT could be considered one of the first - Telescopes from Afar. The telescope, originally called the Remotely Controlled Telescope, has been renamed the Robotically Controlled Telescope to reflect the change in operational control and mode of use. The RCT was a conceptual precursor of today's robotic telescopes, but the actual operation of a remotely controlled telescope was technologically premature for its time, and was subsequently manually operated primarily to conduct optical and infrared observations as well being used as a test bed for new spectroscopic and photometric instruments. In 1995 budget constraints forced the closing of the telescope as part of the Kitt Peak National Observatory (KPNO), following nearly 30 years of distinguished service to KPNO. A request for proposals to operate this telescope was issued to the science community. The RCT consortium, lead by Western Kentucky University, was the successful proposer for operation of the telescope. After several difficult years of retrofitting, refurbishing, and automating the telecope and observatory dome, the telescope has returned to routine science operations in November 2009. The RCT has operated smoothly since that time, with no major interruptions. Observations of objects of interest to the consortium partners (including: comets & asteroids, variable & binary stars, exoplanets, supernovae, quasars & blazars) are being routinely obtained and evaluated. One of the distinguishing features of the RCT is that it is an autonomous observatory designed to handle diverse optical imaging and photometry programs. These include being able to automatically deal with a wide range of observing parameters such as -integration time, sky conditions, repetitions, return visits, filters, air mass, non-sidereal objects, transients etc

  19. Long-term trends in sodium and chloride in the Mohawk River, New York: the effect of fifty years of road-salt application.

    Science.gov (United States)

    Godwin, K S; Hafner, S D; Buff, M F

    2003-01-01

    Ecological studies have demonstrated the adverse effects of road-salt, primarily NaCl, on water quality, flora, and fauna. In this study, we quantified changes in ionic composition and solute flux of water draining the Mohawk River Basin (9103 km(2)) in New York State, from 1952 to 1998. Using various statistical, graphical, and modeling techniques, we showed that concentrations ofNa+ and Cl- have increased by 130 and 243%, respectively, while other constituents have decreased or remained constant. The use of de-icing salt on roads within the watershed, which we estimate at 39 kg km(-2) day(-1), appears to be the primary mechanism responsible for reported increases, accounting for the increase in NaCl export from 16 to 46 kg km(-2) day(-1) over the 47-year period.Moreover, despite population decline within this rural upstate watershed, increased environmental stewardship, and The Clean Water Act, concentrations of Na+ and Cl- still increased during the 1990s.

  20. [Effects of fire recurrence on fire behaviour in cork oak woodlands (Quercus suber L.) and Mediterranean shrublands over the last fifty years].

    Science.gov (United States)

    Schaffhauser, Alice; Pimont, François; Curt, Thomas; Cassagne, Nathalie; Dupuy, Jean-Luc; Tatoni, Thierry

    2015-12-01

    Past fire recurrence impacts the vegetation structure, and it is consequently hypothesized to alter its future fire behaviour. We examined the fire behaviour in shrubland-forest mosaics of southeastern France, which were organized along a range of fire frequency (0 to 3-4 fires along the past 50 years) and had different time intervals between fires. The mosaic was dominated by Quercus suber L. and Erica-Cistus shrubland communities. We described the vegetation structure through measurements of tree height, base of tree crown or shrub layer, mean diameter, cover, plant water content and bulk density. We used the physical model Firetec to simulate the fire behaviour. Fire intensity, fire spread, plant water content and biomass loss varied significantly according to fire recurrence and vegetation structure, mainly linked to the time since the last fire, then the number of fires. These results confirm that past fire recurrence affects future fire behaviour, with multi-layered vegetation (particularly high shrublands) producing more intense fires, contrary to submature Quercus woodlands that have not burnt since 1959 and that are unlikely to reburn. Further simulations, with more vegetation scenes according to shrub and canopy covers, will complete this study in order to discuss the fire propagation risk in heterogeneous vegetation, particularly in the Mediterranean area, with a view to a local management of these ecosystems. Copyright © 2015 Académie des sciences. Published by Elsevier SAS. All rights reserved.

  1. The Impossible Sustainability of the Bay of Brest? Fifty Years of Ecosystem Changes, Interdisciplinary Knowledge Construction and Key Questions at the Science-Policy-Community Interface

    Directory of Open Access Journals (Sweden)

    Olivier Ragueneau

    2018-04-01

    Full Text Available In this contribution, the study of the Bay of Brest ecosystem changes over the past 50 years is used to explore the construction of interdisciplinary knowledge and raise key questions that now need to be tackled at the science-policy-communities interface. The Bay of Brest is subject to a combination of several aspects of global change, including excessive nutrient inputs from watersheds and the proliferation of invasive species. These perturbations strongly interact, affecting positively or negatively the ecosystem functioning, with important impacts on human activities. We first relate a cascade of events over these five decades, linking farming activities, nitrogen, and silicon biogeochemical cycles, hydrodynamics of the Bay, the proliferation of an exotic benthic suspension feeder, the development of the Great scallop fisheries and the high biodiversity in maerl beds. The cascade leads to today's situation where toxic phytoplankton blooms become recurrent in the Bay, preventing the fishery of the great scallop and forcing the fishermen community to switch pray and alter the maerl habitat and the benthic biodiversity it hosts, despite the many scientific alerts and the protection of this habitat. In the second section, we relate the construction of the interdisciplinary knowledge without which scientists would never have been able to describe these changes in the Bay. Interdisciplinarity construction is described, first among natural sciences (NS and then, between natural sciences and human and social sciences (HSS. We finally ask key questions at the science-policy interface regarding this unsustainable trend of the Bay: How is this possible, despite decades of joint work between scientists and fishermen? Is adaptive co-management a sufficient condition for a sustainable management of an ecosystem? How do the different groups (i.e., farmers, fishermen, scientists, environmentalists, with their diverse interests, take charge of this situation

  2. Oak Ridge Dose Reconstruction annual report for calendar year 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    Calendar year 1997 was the third full year of work on the Oak Ridge Dose Reconstruction. Activities are summarized on the following individual project tasks: Task 1 -- Investigation of radioiodine releases from X-10 radioactive lanthanum processing; Task 2 -- Investigation of mercury releases from Y-12 lithium enrichment; Task 3 -- Investigation of PCBs in the environment near Oak Ridge; Task 4 -- Investigation of radionuclides released from White Oak Creek to the Clinch River; Task 5 -- Systematic searching of records repositories; Task 6 -- Evaluation of the quality of uranium monitoring data and a screening evaluation of potential off-site health risks; and Task 7 -- Performance of screening for additional materials not evaluated in the feasibility study.

  3. Year 2000 estimated population dose for the Tennessee Valley region

    International Nuclear Information System (INIS)

    Fletcher, J.F.; Strauch, S.; Siegel, G.R.; Witherspoon, J.P.

    1976-01-01

    A comprehensive study has recently been completed of the potential regional radiological dose in the Tennessee and Cumberland river basins in the year 2000, resulting from the operation of nuclear facilities. This study, sponsored jointly by the U.S. Energy Research and Development Administration and the Tennessee Valley Authority, was performed by the Hanford Engineering Development Laboratory (HEDL), the Oak Ridge National Laboratory (ORNL), and the Atmospheric Turbulence and Diffusion Laboratory (ATDL). This study considered the operation in the year 2000 of 33,000 MWe of nuclear capacity within the study area, and of 110,000 MWe in adjacent areas, together with supporting nuclear fuel fabrication and reprocessing facilities. Air and water transport models used and methods for calculating nuclide concentrations on the ground are discussed

  4. Oak Ridge Dose Reconstruction annual report for calendar year 1997

    International Nuclear Information System (INIS)

    1998-01-01

    Calendar year 1997 was the third full year of work on the Oak Ridge Dose Reconstruction. Activities are summarized on the following individual project tasks: Task 1 -- Investigation of radioiodine releases from X-10 radioactive lanthanum processing; Task 2 -- Investigation of mercury releases from Y-12 lithium enrichment; Task 3 -- Investigation of PCBs in the environment near Oak Ridge; Task 4 -- Investigation of radionuclides released from White Oak Creek to the Clinch River; Task 5 -- Systematic searching of records repositories; Task 6 -- Evaluation of the quality of uranium monitoring data and a screening evaluation of potential off-site health risks; and Task 7 -- Performance of screening for additional materials not evaluated in the feasibility study

  5. School Finance: Fifty Years of Expansion.

    Science.gov (United States)

    Guthrie, James W.

    1997-01-01

    Analyzes the increases in per-pupil expenditures in elementary and secondary education since World War II and discusses factors contributing to the increase. A significant cause is the 86% inflation-adjusted increase in teacher salaries between 1949-50 and 1971-72, although teacher salaries have increased little since that time. (SLD)

  6. The Pentagon: The First Fifty Years

    Science.gov (United States)

    1992-01-01

    Secretary of War Stimson reviewed it. Initially "skeptical," Stimson finally concurrcd. He wrote in his diary that "it will cost a lot of money, but it will...wrote in his diary : "It struck me as so fantastic that I did not express myself to him, but I told Somervell afterwards... I should absolutely refuse to...8217l Jill10 i"Il LtW ILI il Ih( "IM Ol*110 II )’(1 ol11 ,(\\ o n u l tl,1 + Rivci Eqttancc At ’M AyA I’wP e Pentagon Lore The Pentagon entered into

  7. Chemists in Rijeka Together for Fifty Years

    Directory of Open Access Journals (Sweden)

    Milin, C.

    2009-06-01

    Full Text Available Whatever part of the World you come from, when you come to Rijeka you came to the heart of Europe. Rijeka is waiting for you with the scent of its sea and the hospitality of its people. Rijeka is a town of unusual, turbulent and intersected history. At the end of the IX Century the area of Rijeka was one of the most powerful industrial zones in Europe. Prof. Eugen Cerkovnikov, Ph. D., a much-respected chemist, first Head of the Department for Chemistry and Biochemistry on the then newly established Medical School in Rijeka, launched the initiative to form a branch-office of the Croatian Chemist Society in Rijeka. On 18 January, 1958 in the Big Classroom of the Medical School in Rijeka the Founding Assembly was held, and many respected scientists of that period were present.In 1960, the Rijeka branch-office of the Croatian Chemist Society merged with the Society of Chemists and Technologists and in 1973 the Biochemists section joined. In the five decades of its existence, the love towards chemistry, biochemistry, molecular biology, technology and chemical engineering, the love towards the basis of natural sciences and the wish to educate new, progressive generations formed the mission of the Society. The Society does not want to be closed in a guild organisation; its aim is to open its doors towards all those striving to progress.Former presidents of the Society were: Eugen Cerkovnikov (1958-1974, Marijan Kolombo (1974-1980, Josip Šilipeter (1980-1984, Marinko Oršia (1984-1996 i Nikola Bla?evia (1996-; and each one of them marked his era. Transitional circumstances have shut down forever many, until recently, extremely powerful industries in Rijeka. Today, Rijeka is searching for new paths, and we believe that our Society will continue to work on and give its contribution to this search.

  8. Sandia National Laboratories: The First Fifty Years

    Energy Technology Data Exchange (ETDEWEB)

    MORA,CARL J.

    1999-11-03

    On Nov. 1, 1999, Sandia National Laboratories celebrates its 50th birthday. Although Sandia has its roots in the World War II-era Manhattan Project, Sandia began operating as a separate nuclear weapons engineering laboratory under the management of AT&T on Nov. 1, 1949. Today the lab employs more than 7,000 people at its two sites in Albuquerque and Livermore, California, and has research and development missions in national security, energy and environmental technologies, and U.S. economic competitiveness. Lockheed Martin Corporation operates Sandia for the US. Department of Energy.

  9. The Fifty Year Rehabilitation of the Egg

    Directory of Open Access Journals (Sweden)

    Donald J. McNamara

    2015-10-01

    Full Text Available The 1968 American Heart Association announced a dietary recommendation that all individuals consume less than 300 mg of dietary cholesterol per day and no more than three whole eggs per week. This recommendation has not only significantly impacted the dietary patterns of the population, but also resulted in the public limiting a highly nutritious and affordable source of high quality nutrients, including choline which was limited in the diets of most individuals. The egg industry addressed the egg issue with research documenting the minimal effect of egg intake on plasma lipoprotein levels, as well as research verifying the importance of egg nutrients in a variety of issues related to health promotion. In 2015 dietary cholesterol and egg restrictions have been dropped by most health promotion agencies worldwide and recommended to be dropped from the 2015 Dietary Guidelines for Americans.

  10. Strategies for the next fifty years

    International Nuclear Information System (INIS)

    1996-01-01

    This report presents a professional, global and unrestricted overview of the nuclear energy development and using, and the worldwide related research. The document also presents the strategies for the next half-century

  11. Fifty Years of HF Doppler Observations

    Directory of Open Access Journals (Sweden)

    T Ogawa

    2009-04-01

    Full Text Available High frequency Doppler observations of the ionosphere began in August of 1957 in Kyoto. The number of the observation points worldwide were about 40 in 1980 and are about 20 at present. By this method the movement of the ionosphere reflection height and electron density below the height can be observed. Such variations are occurred by a wide variety of sources.

  12. Immunotoxicology: fifty years of global scientific progress.

    Science.gov (United States)

    McKarns, Susan C; Kerkvliet, Nancy I; Dean, Jack H; Bonn, Michael B; Cohen, Mitchell D; Franko, Jennifer; Laiosa, Michael D; Lawrence, B Paige; Luebke, Robert W; Luster, Michael I; Miller, Patrick G; Palmer, Rachel K; Pfau, Jean C; Raman, Priyadarshini; Regal, Jean F; Rodgers, Kathleen E; Schondelmeyer, Rio S; Zhang, Xiaochu; Burns-Naas, Leigh Ann

    2012-01-01

    The Immunotoxicology Specialty Section of the Society of Toxicology (SOT) celebrated the 50(th) Anniversary of the SOT by constructing a poster to highlight the milestones of Immunotoxicology during that half-century period. This poster was assembled by an ad hoc committee and intertwines in words, citations, graphics, and photographs our attempts to capture a timeline reference of the development and progressive movement of immunotoxicology across the globe. This poster was displayed during the 50(th) Annual SOT Meeting in Washington DC in March, 2011. The poster can be accessed by any Reader at the SOT Website via the link http://www.toxicology.org/AI/MEET/AM2011/posters_rcsigss.asp#imss. We dedicate this poster to all of the founders and the scientists that followed them who have made the discipline of Immunotoxicology what it is today.

  13. Fifty Years of Physics of Living Systems.

    Science.gov (United States)

    Latash, Mark L

    2016-01-01

    The equilibrium-point hypothesis and its more recent version, the referent configuration hypothesis, represent the physical approach to the neural control of action. This hypothesis can be naturally combined with the idea of hierarchical control of movements and of synergic organization of the abundant systems involved in all actions. Any action starts with defining trajectories of a few referent coordinates for a handful of salient task-specific variables. Further, referent coordinates at hierarchically lower levels emerge down to thresholds of the tonic stretch reflex for the participating muscles. Stability of performance with respect to salient variables is reflected in the structure of inter-trial variance and phenomena of motor equivalence. Three lines of recent research within this framework are reviewed. First, synergic adjustments of the referent coordinate and apparent stiffness have been demonstrated during finger force production supporting the main idea of control with referent coordinates. Second, the notion of unintentional voluntary movements has been introduced reflecting unintentional drifts in referent coordinates. Two types of unintentional movements have been observed with different characteristic times. Third, this framework has been applied to studies of impaired movements in neurological patients. Overall, the physical approach searching for laws of nature underlying biological movement has been highly stimulating and productive.

  14. Fifty Years of Scholarship in Media Ethics

    Science.gov (United States)

    Christians, Clifford G.

    1977-01-01

    Describes changing attitudes toward the role of mass media ethics, as reflected in the literature. Available from: Journal of Communication, The Annenberg School of Communications, University of Pennsylvania, 3620 Walnut Street, Philadelphia, PA 19104, $15.00 yr; $4.00 sc. (KS)

  15. History * Autobiography * Growth: (Fifty Years since Dartmouth)

    Science.gov (United States)

    Doecke, Brenton

    2016-01-01

    This essay explores how my professional experiences as an English educator have been shaped by the values and beliefs that are typically associated with the Dartmouth Seminar of 1966 as they were presented by John Dixon in his immensely influential report of that seminar, "Growth Through English." Rather than seeing "Growth"…

  16. Fifty years chlorpromazine: a historical perspective.

    Science.gov (United States)

    Ban, Thomas A

    2007-08-01

    Chlorpromazine was synthesized in December 1951 in the laboratories of Rhône-Poiulenc, and became available on prescription in France in November 1952. Its effectiveness was reflected in the transformation of disturbed wards; its commercial success stimulated the development of other psychotropic drugs. Recognition of chemical mediation at the site of the synapse, followed by the introduction of the spectrophotofluorimeter first, and receptor assays subsequently, led to the demonstration that chlorpromazine blocks dopamine receptors. Treatment with chlorpromazine focused attention on the heterogeneity of schizophrenia in terms of responsiveness to treatment. By the mid-1980s there was sufficient evidence to believe that resolving this heterogeneity is a prerequisite for developing more effective treatments. Chlorpromazine was instrumental in the development of neuropsychopharmacology, a new discipline dedicated to the study of mental pathology with the employment of centrally acting drugs.

  17. Medulloblastoma: time-dose relationship based on a 30-year review

    International Nuclear Information System (INIS)

    Charco, John O. del; Bolek, Timothy W.; McCollough, W. Mark; Maria, Bernard L.; Kedar, Amos; Braylan, Raul C.; Mickle, J. Parker; Buatti, John M.; Mendenhall, Nancy P.; Marcus, Robert B.

    1998-01-01

    Purpose: Time-dose relationships have proven important in many cancer sites. This study evaluates the time factors involved in the successful postoperative radiotherapy of medulloblastoma, based on a 30-year experience in a single institution. Methods and Materials: Fifty-three patients with medulloblastoma received postoperative craniospinal radiotherapy with curative intent between 1963 and 1993. Seven patients (13%) underwent biopsy alone, 28 patients (53%) had subtotal excision, and 18 patients (34%) had gross total excision. Eleven patients received adjuvant chemotherapy. The mean posterior fossa dose was 53.1 Gy; most patients received 54.0 Gy (range, 34.3 to 69.6 Gy). For 41 patients receiving once-a-day therapy, the mean dose was 50.6 Gy (range, 34.3 to 56.0 Gy). For 12 patients receiving twice-a-day therapy, the mean dose was 61.8 Gy (range, 52.6 to 69.6 Gy). Minimum follow-up was 2 years, and median follow-up was 10.7 years. Survival, freedom from relapse, and disease control in the posterior fossa were calculated using the Kaplan-Meier method, and multivariate analysis was performed for prognostic factors. Variables related to radiotherapy were examined, including dose to the craniospinal axis, dose to the posterior fossa, fractionation (once-a-day vs. twice-a-day), use of adjuvant chemotherapy, risk group [high (≥T3b or ≥M1) or low (≤T3a and M0-MX)], interval between surgery and radiotherapy (excluding patients receiving chemotherapy before radiotherapy), and duration of radiotherapy. Results: At 5 and 10 years, overall survival rates were 68 and 64%, respectively, and freedom-from-relapse rates were 61 and 52%, respectively. Rates of disease control in the posterior fossa at 5 and 10 years were 79 and 68%, respectively. At 5 years, absolute survival rates after biopsy alone, subtotal excision, and gross total excision were 43, 67, and 78%, respectively (p = 0.04), and posterior fossa control rates were 27, 89, and 83%, respectively (p = 0

  18. Atoms for peace plus fifty

    International Nuclear Information System (INIS)

    Eisenhower, S.

    2003-01-01

    One of Dwight Eisenhower's most significant political legacies stemmed from his management of the nuclear question. Five decades after Eisenhower's 'Atoms for Peace' speech before the United Nations, the nuclear dilemma persists but the world is a different, and I would submit, a better place today than it might have been had that vision not been articulated, or its proposals not advanced. The 'Atoms for Peace' speech had a number of objectives, but it is over arching goal was to propose a set of ideas, a nuclear strategy, which would call on the Soviets to cooperate internationally for the betterment of mankind. This would reengage the Soviets in discussions on nuclear matters at a time when arms control talks had stalled, but it would also offer hope, and a practical set of ideas, to the developing world. 'Atoms for Peace' spawned many developments, including the establishment of the International Atomic Energy Agency, and eventually the Nuclear Non-Proliferation Treaty. While 'Atoms for Peace', as well as the institutions it created, has come under fire in recent years, it is hard to imagine what the world would have been like without it. Largely through the international Atomic Energy Agency, nations around the world have participated in research and development programs, including the use of nuclear energy in important civilian applications. Nuclear electric power accounts for nearly one-fifth of the world's electricity - reducing global tensions by replacing oil in many applications, and providing much of the world's electricity that is generated without the release of greenhouse gases or other destructive emissions. Many other nuclear and radiation-related technologies, especially radiopharmaceuticals and medical advances involving radiation, have resulted in large part from research spawned by 'Atoms for Peace'. Millions of lives have been saved in the process. While the 'nuclear dilemma' remains a challenge almost as complex as it was fifty years ago, the

  19. The D1 method: career dose estimation from a combination of historical monitoring data and a single year's dose data

    International Nuclear Information System (INIS)

    Sont, W.N.

    1995-01-01

    A method is introduced to estimate career doses from a combination of historical monitoring data and a single year's dose data. This method, called D1 eliminates the bias arising from incorporating historical dose data from times when occupational doses were generally much higher than they are today. Doses calculated by this method are still conditional on the preservation of the status quo in the effectiveness of radiation protection. The method takes into account the variation of the annual dose, and of the probability of being monitored, with the time elapsed since the start of a career. It also allows for the calculation of a standard error of the projected career dose. Results from recent Canadian dose data are presented. (author)

  20. Dose calibrators quality controls in Switzerland: six years of experience

    International Nuclear Information System (INIS)

    Bochud, F.; Spring, Ph.; Baechler, S.; Twerenbold, D.; Linder, R.; Leibundgut, F.

    2006-01-01

    In Switzerland, the legal use of open radioactive sources in nuclear medicine and the general requirements for quality controls are defined in a federal ordinance. The metrological traceability is guaranteed through a directive of the Swiss metrological office (M.E.T.A.S.) that requires each instrument to be monitored at least once a year through either a verification or an intercomparison. The verification is performed onsite by an accredited laboratory with a set of three gamma sources (Co-57, Cs-137 and Co-60) and - if applicable - a beta source (Sr-90/Y- 90). The intercomparison is made through conventional mail. A source of I-131 or Tc- 99 m is measured both in the nuclear medicine department and in an accredited laboratory. The maximum tolerated error is 10% for gamma sources and 20% for beta sources. This methodology guarantees that the instruments have a correct response for most of the energy range used in practice. Not all nuclides are systematically probed and manufacturers are ultimately responsible for the calibration factors. The precision of the measurements performed in Switzerland is satisfactory with only about 6% of the measurements out of the tolerances. This monitoring also allowed us to improve the skills of the personnel and update the park of instruments by getting rid of dose calibrators displaying old units. (authors)

  1. Dose calibrators quality controls in Switzerland: six years of experience

    Energy Technology Data Exchange (ETDEWEB)

    Bochud, F.; Spring, Ph.; Baechler, S. [Institut Universitaire de Radiophysique Appliquee, Lausanne (Switzerland); Twerenbold, D. [METAS, Lindenweg 50, Bern-Wabern (Switzerland); Linder, R. [Bundesamt fur Gesundheit, Abteilung Strahlenschutz, Bern (Switzerland); Leibundgut, F. [Raditec radiation and technology, Schoftland (Switzerland)

    2006-07-01

    In Switzerland, the legal use of open radioactive sources in nuclear medicine and the general requirements for quality controls are defined in a federal ordinance. The metrological traceability is guaranteed through a directive of the Swiss metrological office (M.E.T.A.S.) that requires each instrument to be monitored at least once a year through either a verification or an intercomparison. The verification is performed onsite by an accredited laboratory with a set of three gamma sources (Co-57, Cs-137 and Co-60) and - if applicable - a beta source (Sr-90/Y- 90). The intercomparison is made through conventional mail. A source of I-131 or Tc- 99 m is measured both in the nuclear medicine department and in an accredited laboratory. The maximum tolerated error is 10% for gamma sources and 20% for beta sources. This methodology guarantees that the instruments have a correct response for most of the energy range used in practice. Not all nuclides are systematically probed and manufacturers are ultimately responsible for the calibration factors. The precision of the measurements performed in Switzerland is satisfactory with only about 6% of the measurements out of the tolerances. This monitoring also allowed us to improve the skills of the personnel and update the park of instruments by getting rid of dose calibrators displaying old units. (authors)

  2. Personal dose estimations for Olympic Dam's first year of production

    International Nuclear Information System (INIS)

    Sonter, M.; Hondros, J.

    1989-01-01

    Underground development activities have been underway at Olympic Dam since 1983; commercial ore extraction commenced in early 1988; and the metallurgical treatment plant commenced operation in mid 1988. Detailed and extensive radiation monitoring programs have been in place since commencement of activities and have enabled detailed individual assessment of personal doses. Results are shown, in histogram form, of doses to full and part-time underground mine workers pre-1988 and for calendar 1988; and projected annual doses to treatment plant workers for the period July 1988 to July 1989. Comments are included on the dose calculation assumptions applying in mine and mill and on the degree of conservatism of these assumptions. The doses presented show compliance with the limits quoted in the Australian code of practice; they compare well with other underground uranium mines, and they indicate effective pursuit of the 'alara' principle. 7 figs., 1 tab

  3. Radiation doses from common radiographic procedures: a ten year perspective

    International Nuclear Information System (INIS)

    Heggie, J.C.P.; Wilkinson, L.E.

    2000-01-01

    Using a semi-empirical model patient doses for a number of plain film radiographic procedures following the implementation of Computed Radiography (CR) technology in our Hospital have been evaluated. The results are presented in terms of the entrance surface dose (ESD) and the effective dose. A comparison of these results, with those reported previously for 1988, suggests that with the exception of chest radiography, patient doses have decreased although in many instances the decreases are not statistically significant. The finding for chest examinations stands apart from all others in that the introduction of CR technology has resulted in a substantial increase in patient dose for the PA view by at least 18%. The major reason for these apparently contradictory findings has its roots in the effectively variable speed of CR systems and the willingness of radiologists to accept more noise in some CR images

  4. Dose escalation with 3-D CRT in prostate cancer: five year dose responses and optimal treatment

    International Nuclear Information System (INIS)

    Hanks, Gerald; Hanlon, Alexandra; Pinover, Wayne; Hunt, Margie; Movsas, Benjamin; Schultheiss, Timothy

    1997-01-01

    Purpose: To report 5 yr dose responses in prostate cancer patients treated with 3D-CRT and describe optimal treatment based on dose response. Methods: Dose escalation was studied in 233 consecutive patients treated with 3D-CRT between 3/89 and 10/92. All surviving patients have >32 mo follow-up, the median follow-up is 55 mo. Estimated logistic cumulative distribution functions (logit response models) fit to 5 yr actuarial bNED outcome are reported for 3 dose groups in each of 3 pretreatment PSA groupings (10-19.9 ng/ml and 20+ ng/ml); no dose response is observed for patients with pretreatment PSA <10 ng/ml. Logit response models fit to 5 yr actuarial late morbidity rates (grade 2 GI, grade 2 GU, grade 3,4 GI) are also reported for 4 dose groups. Patients are treated with CT planned 4-field conformal technique where the PTV encompasses the CTV by 1.0 cm in all directions including the anterior rectal wall margin. Patients are followed at 6 mo intervals with PSA and DRE, and bNED failure is defined as PSA ≥1.5 ng/ml and rising on two consecutive measures. The Fox Chase modification of the LENT morbidity scale is used for GI morbidity including any blood transfusion and/or more than 2 coagulations as a grade 3 event. GU morbidity follows the RTOG scale. Results: The logit response models based on 5 yr bNED results have slopes of 27% and 18% for pretreatment PSA grouping 10-19.9 ng/ml and 20+ ng/ml, respectively. The 50% bNED response is observed at 71 Gy and 80 Gy respectively, while the 80% bNED response is observed at 76 Gy for the 10-19.9 ng/ml group and estimated at 88 Gy for the 20+ ng/ml group. Logit dose response models for grade 2 GI and grade 2 GU morbidity show markedly different slopes, 23% versus 4%, respectively. The slope for grade 3,4 GI is 12%. The dose response model indicates grade 3,4 GI complication rates at 5 yrs are 8% at 76 Gy and 12% at 80 Gy. Conclusion: Based on 5 yr results, we can draw some conclusions about appropriate dose from these

  5. Offsite radiation doses summarized from Hanford environmental monitoring reports for the years 1957-1984

    International Nuclear Information System (INIS)

    Soldat, J.K.; Price, K.R.; McCormack, W.D.

    1986-02-01

    Since 1957, evaluations of offsite impacts from each year of operation have been summarized in publicly available, annual environmental reports. These evaluations included estimates of potential radiation exposure to members of the public, either in terms of percentages of the then permissible limits or in terms of radiation dose. The estimated potential radiation doses to maximally exposed individuals from each year of Hanford operations are summarized in a series of tables and figures. The applicable standard for radiation dose to an individual for whom the maximum exposure was estimated is also shown. Although the estimates address potential radiation doses to the public from each year of operations at Hanford between 1957 and 1984, their sum will not produce an accurate estimate of doses accumulated over this time period. The estimates were the best evaluations available at the time to assess potential dose from the current year of operation as well as from any radionuclides still present in the environment from previous years of operation. There was a constant striving for improved evaluation of the potential radiation doses received by members of the public, and as a result the methods and assumptions used to estimate doses were periodically modified to add new pathways of exposure and to increase the accuracy of the dose calculations. Three conclusions were reached from this review: radiation doses reported for the years 1957 through 1984 for the maximum individual did not exceed the applicable dose standards; radiation doses reported over the past 27 years are not additive because of the changing and inconsistent methods used; and results from environmental monitoring and the associated dose calculations reported over the 27 years from 1957 through 1984 do not suggest a significant dose contribution from the buildup in the environment of radioactive materials associated with Hanford operations

  6. Annual dose distribution of Nuclear Malaysia radiation workers for monitoring period from year 2003 to 2007

    International Nuclear Information System (INIS)

    Hairul Nizam Idris; Azimawati Ahmad; Norain Ab Rahman

    2008-08-01

    Estimation of radiation dose (external exposure) received by Nuklear Malaysia's radiation workers are measured by using personal dosimetry device which are provided by SSDL-Nuklear Malaysia. Dose assessment report for monitoring period from year 2003 - 2007 shows that almost all radiation workers received annual doses less than 20 mSv, only in very small percentage of radiation workers received annual doses between 20.1 to 50 mSv and none of the workers received doses higher than 50 mSv/year. Exposure dose below 20 mSv/year (the new annual dose limit to be used in Malaysia soon) could be fully achieved by improving the compliance with the safety regulations and enhancing the awareness about radiation safety among the workers. (Author)

  7. Summary of fifty years research on the late effects of atomic bomb irradiation in Japan with special reference to possible similar late effects by nuclear weapons tests in Semipalatinsk

    International Nuclear Information System (INIS)

    Tomonaga, M.

    2000-01-01

    The investigation clearly demonstrated statistically significant increases of risks for acute myeloid and lymphoid leukemia, chronic myeloid leukemia, and solid tumors including thyroid cancer, gastrointestinal cancers, lung cancer, hepatoma and skin cancer. The excess relative risks was highest for acute lymphoid leukemia, followed by chronic myeloid leukemia, acute myeloid leukemia, and solid cancer. The increased risk for leukemia has almost completely disappeared after 50 years, whereas the risks for cancers are apparently persisting giving a great threat to general health of atomic bomb survivors. These observations can be directly referred to the possible late effects of the acute and chronic exposure to irradiation caused by nuclear tests in Semipalatinsk region. Recent dose-estimation efforts by Kazakhstan, US and Japanese scientists indicated that there had been Hiroshima/Nagasaki atomic bomb equivalent high-dose exposure in some residents around the test sites. Some researchers suggested increased risks for malignant diseases such as leukemia and cancers. Unfortunately there was a lack of high-quality statistics in the Semipalatinsk survey, providing a considerable difficulty in interpreting the estimated incidences of such malignant diseases

  8. First Year of the Development of the central State Dose Register in Slovenia

    International Nuclear Information System (INIS)

    Janzekovic, H.; Breznik, B.; Jovanovic, P.; Zdesar, U.; Rojc, J.; Stuhec, M.; Vaupotic, J.

    2001-01-01

    Full text: In order to improve the registration of doses received by around 4500 workers who annually work with the ionising radiation sources in Slovenia the Health Inspectorate started to build a Central State Dose Register in 1999. Today the register includes data concerning all workers including outside workers and is filled by six laboratories from four institutions. The doses are measured in around 500 enterprises. The register built in Access 97 accepts data in electronic forms periodically from the dosimetry services. The external doses are reported monthly and the internal doses are reported usually once per year. The identification of a person is based on personal data which are not a subject of changes generally. The received doses are related to the time period during which the doses were received, licensee, employer, type of the work, type of the source and also to the cumulative dose received in the current year. The reported doses are always related to the dosimetry service so that a revaluation of the dose is always possible if necessary. As a rule the part of health surveillance data and the education of workers related to the radiation protection are also given. The cumulative doses of workers received before January 1, 2000 are reported as well. The developmental problems of the register related to extensiveness of the use of the ionising radiation sources in Slovenia will be discussed and the applied solutions based on ICRP 60 and 96/29/Euratom will be given. (author)

  9. Cumulative high doses of inhaled formoterol have less systemic effects in asthmatic children 6-11 years-old than cumulative high doses of inhaled terbutaline

    DEFF Research Database (Denmark)

    Kaae, Rikke; Agertoft, Lone; Pedersen, Sören

    2004-01-01

    OBJECTIVES: To evaluate high dose tolerability and relative systemic dose potency between inhaled clinically equipotent dose increments of formoterol and terbutaline in children. METHODS: Twenty boys and girls (6-11 years-old) with asthma and normal ECGs were studied. Ten doses of formoterol (Oxi...

  10. Fifty consecutive pancreatectomies without mortality

    Directory of Open Access Journals (Sweden)

    Enio Campos Amico

    Full Text Available Objective: to report the group's experience with a series of patients undergoing pancreatic resection presenting null mortality rates. Methods: we prospectively studied 50 consecutive patients undergoing pancreatic resections for peri-ampullary or pancreatic diseases. Main local complications were defined according to international criteria. In-hospital mortality was defined as death occurring in the first 90 postoperative days. Results: patients' age ranged between 16 and 90 years (average: 53.3. We found anemia (Hb < 12g/dl and preoperative jaundice in 38% and 40% of cases, respectively. Most patients presented with peri-ampullary tumors (66%. The most common surgical procedure was the Kausch - Whipple operation (70%. Six patients (12% needed to undergo resection of a segment of the mesenteric-portal axis. The mean operative time was 445.1 minutes. Twenty two patients (44% showed no clinical complications and presented mean hospital stay of 10.3 days. The most frequent complications were pancreatic fistula (56%, delayed gastric emptying (17.1% and bleeding (16%. Conclusion : within the last three decades, pancreatic resection is still considered a challenge, especially outside large specialized centers. Nevertheless, even in our country (Brazil, teams seasoned in such procedure can reach low mortality rates.

  11. DITTY - a computer program for calculating population dose integrated over ten thousand years

    International Nuclear Information System (INIS)

    Napier, B.A.; Peloquin, R.A.; Strenge, D.L.

    1986-03-01

    The computer program DITTY (Dose Integrated Over Ten Thousand Years) was developed to determine the collective dose from long term nuclear waste disposal sites resulting from the ground-water pathways. DITTY estimates the time integral of collective dose over a ten-thousand-year period for time-variant radionuclide releases to surface waters, wells, or the atmosphere. This document includes the following information on DITTY: a description of the mathematical models, program designs, data file requirements, input preparation, output interpretations, sample problems, and program-generated diagnostic messages

  12. Age-specific radiation dose commitment factors for a one-year chronic intake

    International Nuclear Information System (INIS)

    Hoenes, G.R.; Soldat, J.K.

    1977-11-01

    During the licensing process for nuclear facilities, radiation doses and dose commitments must be calculated for people in the environs of a nuclear facility. These radiation doses are determined by examining characteristics of population groups, pathways to people, and radionuclides found in those pathways. The pertinent characteristics, which are important in the sense of contributing a significant portion of the total dose, must then be analyzed in depth. Dose factors are generally available for adults, see Reference 1 for example, however numerous improvements in data on decay schemes and half-lives have been made in recent years. In addition, it is advisable to define parameters for calculation of the radiation dose for ages other than adults since the population surrounding nuclear facilities will be composed of various age groups. Further, since infants, children, and teens may have higher rates of intake per unit body mass, it is conceivable that the maximally exposed individual may not be an adult. Thus, it was necessary to develop new radiation-dose commitment factors for various age groups. Dose commitment factors presented in this report have been calculated for a 50-year time period for four age groups

  13. Staff radiation doses during eight years in a nuclear medicine radiopharmacy

    International Nuclear Information System (INIS)

    Jansen, S.E.; Aswegen, A. van; Loetter, M.G.; Herbst, C.P.; Otto, A.C.; Orange Free State Univ., Bloemfontein

    1994-01-01

    Staff working in the radiopharmacy and nursing staff responsible for injecting radionuclides are being monitored constantly in our department. We report here on the effective doses and doses to the hands received by staff at two hospitals during 8 years from January 1985 to December 1992. In addition to the doses determined monthly by the South African Bureau of Standards' Radiation Protection Service (SABS), radiation doses received to the hands and whole body were measured every week using lithium fluoride thermoluminescent dosimetry (TLD). The highest total radiation dose received in any one year by any one person at hospital A was 233.53 mSv to the hands, and 10.20 mSv and 8.37 mSv to the whole body depending on the dosemeter used. The corresponding values for hospital B were 54.05 mSv to the hands and 6.94 mSv and 4.43 mSv to the whole body. If only one radiographer should do all the work calculated highest dose received would be 447.06 mSv to the hands and 9.68 mSv SABS effective dose. The radiation doses to staff were well within the limits prescribed. (Author)

  14. Guaifenesin Pharmacokinetics Following Single‐Dose Oral Administration in Children Aged 2 to 17 Years

    Science.gov (United States)

    Thompson, Gary A.; Solomon, Gail; Albrecht, Helmut H.; Reitberg, Donald P.

    2016-01-01

    Abstract This study characterized guaifenesin pharmacokinetics in children aged 2 to 17 years (n = 40) who received a single oral dose of guaifenesin (age‐based doses of 100‐400 mg) 2 hours after breakfast. Plasma samples were obtained before and for 8 hours after dosing and analyzed for guaifenesin using liquid chromatography‐tandem mass spectrometry. Pharmacokinetic parameters were estimated using noncompartmental methods, relationships with age were assessed using linear regression, and dose proportionality was assessed on 95% confidence intervals. Based on the upper dose recommended in the monograph (for both children and adolescents), area under the curve from time zero to infinity and maximum plasma concentration both increased with age. However, when comparing the upper dose for children aged 2 to 11 years with the lower dose for adolescents aged 12 to 17 years, similar systemic exposure was observed. As expected due to increasing body size, oral clearance (CLo) and terminal volume of distribution (Vz/F) increased with age. Due to a larger increase in Vz/F than CLo, an increase in terminal exponential half‐life was also observed. Allometric scaling indicated no maturation‐related changes in CLo and Vz/F. PMID:26632082

  15. Tennessee Valley region study: potential year 2000 radiological dose to population resulting from nuclear facility operations

    International Nuclear Information System (INIS)

    1978-06-01

    A companion report, DOE/ET-0064/1, presents a geographic, cultural, and demographic profile of the Tennessee Valley Region study area. This report describes the calculations of radionuclide release and transport and of the resultant dose to the regional population, assuming a projected installed capacity of 220,000 MW in the year 2000, of which 144,000 MW would be nuclear. All elements of the fuel cycle were assumed to be in operation. The radiological dose was calculated as a one-year dose based on ingestion of 35 different food types as well as for nine non-food pathways, and was reported as dose to the total body and for six specific organs for each of four age groups (infant, child, teen, and adult). Results indicate that the average individual would receive an incremental dose of 7 x 10 -4 millirems in the year 2000 from the operation of nuclear facilities within and adjacent to the region, five orders of magnitude smaller than the dose from naturally occurring radiation in the area. The major contributor to dose was found to be tritium, and the most significant pathways were immersion in air, inhalation of air, transpiration of tritium (absorption through the skin), and exposure radionuclide-containing soil. 60 references

  16. Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years

    DEFF Research Database (Denmark)

    Björkman, Sven; Folkesson, Anna; Jönsson, Siv

    2009-01-01

    in the sparse clinical data. Model-predicted doses (based on age and body weight) to maintain a recommended 0.01 U/mL trough level of FVIII with administration on alternate days started at around 60 U/kg in the small children, decreasing to 10 U/kg or less in middle age. However, "true" dose requirements......, as estimated from individual PK parameter data, showed a much greater variation. CONCLUSION: Appropriate dosing of FVIII for prophylactic treatment cannot be calculated only from body weight and/or age. However, plausible starting doses for most patients would be 1,000 U every other day. FVIII levels should...... can be calculated according to patient characteristics, and (3) to present dosing recommendations for initiating prophylactic treatment. METHODS: A population PK model was developed using data from four PK studies on patients aged 7-74 years. The model was tested on sparse FVIII data from 42...

  17. An EGS4-ready tomographic computational model of a 14-year-old female torso for calculating organ doses from CT examinations

    International Nuclear Information System (INIS)

    Caon, M.; School of Physics and Electronic Systems Engineering, University of South Australia, The Levels Campus, Mawson Lakes, South Australia, 5095; Pattison, J.

    1999-01-01

    Fifty-four consecutive CT scans have been used to construct a tomographic computational model of a 14-year-old female torso suitable for the determination of organ doses from CT. The model, known as ADELAIDE, is in the form of an input file compatible with user codes based on XYZDOS.MOR from the readily available EGS4 Monte Carlo radiation transport code. ADELAIDE's dimensions are close to the Australian averages for her age so the model is representative of a 14-year-old girl. The realistic anatomy in the model differs considerably from that in Cristy's 15-year-old mathematical computational model by having realistically shaped organs that are appropriately located within a real external contour. Average absorbed dose to organs from simulated CT examinations of the chest and abdomen have been calculated for ADELAIDE using EGS4 within a geometry specific to the General Electric Hi-Speed Advantage CT scanner and using an x-ray spectrum calculated using data from the scanner's x-ray tube. The simulations include the scanner's beam shaping filter and patient table. It is suggested that the resulting values have fewer possible sources of uncertainty than organ doses derived from dose coefficients calculated for a MIRD style model with mathematical anatomy and a spectrum that may not match that of the scanner. The organ doses were normalized using the scanner's CTDI measured free-in-air and an EGS4 simulation of the CTDI measurement. Effective dose to the torso from 26-slice chest and 24-slice abdomen examinations (at 120 kV, 200 mAs, 7 mm slices) is 4.6±0.1mSv and 4.3±0.1mSv respectively. (author)

  18. Botulinum Toxin-A Dosing Trends for Adductor Spasmodic Dysphonia at a Single Institution Over 10 Years.

    Science.gov (United States)

    Bradley, Joseph P; Barrow, Emily M; Hapner, Edie R; Klein, Adam M; Johns, Michael M

    2017-05-01

    This study aimed to identify the changes in dosing of botulinum toxin-A for adductor spasmodic dysphonia (ADSD) over a prolonged period. This is a retrospective chart review. One hundred thirteen subjects treated for ADSD from 2003 to 2013 were identified from a clinical database. Subject age, gender, and total injection dose amount were all recorded for all subjects who had at least 10 injections. Fifty-four subjects met criteria for inclusion. There were no age or gender differences in the starting dose for subjects. Dosing decreased significantly compared with the second dose (5.05 ± 1.623 Units), by the sixth dose (4.26 ± 1.698 Units), and continued through the 10th dose (4.08 ± 2.019 Units) (P < 0.005 for all). Botulinum toxin-A dosing for ADSD decreases consistently over subsequent injections after the initial two dose titrations. Copyright © 2017. Published by Elsevier Inc.

  19. The American oil industry and the Fifty-Fifty Agreement of 1950

    International Nuclear Information System (INIS)

    Anderson, T.H.

    1988-01-01

    This paper traces the history of the Fifty-fifty Agreement of 1950, and the role of the American oil industry in that agreement. Regardless of the definition one chooses for the term foreign policy, it can now be argued with considerable force that the Fifty-fifty Agreement was, in fact, the product of American foreign policy. Defining the term narrowly as the enunciated policy of the Executive Branch of Government on matters outside the national boundary, it is clear that a consistent policy had been in place for a long time supporting exactly the type of action which was taken hear. Defining the term broadly, as the defacto cumulative thrust of all competing interest groups within a nation-state (both governmental and private) outside the national boundary, makes the assertion even more clear. Including Aramco and the parent companies in the equation leaves little doubt that the Fifty-fifty Agreement was the product of American foreign policy

  20. Doses from nuclear medicine examinations: A 25-year follow-up study

    International Nuclear Information System (INIS)

    Kairemo, K.J.A.; Korpela, H.

    2001-01-01

    New radiopharmaceuticals have been introduced in nuclear medicine examinations, and on the other hand, the amount of many routine nuclear medicine procedures have been replaced with clinical methods utilising non-ionisating radiation (ultrasonography, MRI). To clarify the situation in Finland, a country wide survey on the use of radiopharmaceuticals in diagnostics and therapy was made in 1975, 1982, 1989, 1994, 1997 and will be made in 2000. A questionnaire was sent to all hospitals and institutes using unsealed sources in both diagnostic and therapeutic nuclear medicine procedures. For each procedure, the pharmaceutical used, the number of procedures and the typical administered activities were recorded. The collective effective doses from nuclear medicine examinations were calculated according to the ICRP formulae similarly for each survey. In Finland, in each of these years, more than 50,000 procedures in more than 30 different laboratories were performed. Significant changes in collective doses were observed: for example, the collective dose from I-131 was 350 manSv in 1975, and 20 manSv in 1997. In 1975, 68% (n=23967) of collective dose originated from I-131, whereas in 1997 the percentage of I-131 in collective dose was 10 % (n=1118). In 1994 and 1997, the use of the three radionuclides (Tc-99m, I-131 and Tl-201) accounted for 96% and 95% of the collective effective dose. Our results indicate that the collective effective dose from nuclear medicine examinations has decreased in last 25 years. National surveys form the basis when setting reference levels for typical nuclear medicine examinations. By introducing reference levels based on national practice it is possible to even decrease the collective effective dose. (author)

  1. Doses from external and internal radiation in Norway during the first year after the Chernobyl accident

    International Nuclear Information System (INIS)

    Strand, P.; Kjoelaas, G.; Reitan, J.B.; Strand, T.; Berthelsen, T.; Selnaes, T.D.

    1990-01-01

    In this article the estimation of monthly doses from external radiation from internal radiation due to ingestion of contaminated food is reported. The monthly doses is estimated for each municipality in Norway for the first 13 months after the Chernobyl accident (from May 1986 to June 1987). The estimation which has been elaborated from an extensive data material, shows that the dose rates from external radiation due to the Chernobyl fallout were for the country as a whole three times higher in the first month after the accident (May 1986) compared with the twelfth month (April 1987). The doses received from intake of radiocesium through food were small in the first three months, but reached almost the double of the doses from the external radiation the 9th month. The reduction in the dose from external radiation was primarily due to the physical half life of radiocesium and washout. The increase in the doses from radiocesium through intake of food was due to the time required for radiocesium to enter the food chain and the biokinetics of radiocesium in humans. There is no significant correlation between the ground activity levels and the activity levels observed in the food which is consumed in the same area. The average internal dose in the first year after the Chernobyl accident was estimated to 0.110 ± 0.006 mSv and the external dose to 0.070 ± 0.007 mSv as an average for the whole country. 13 refs., 3 figs., 4 tabs

  2. A 10-year review of the dose history of radiation workers in the University of Surrey

    International Nuclear Information System (INIS)

    Parami, V.K.

    1991-09-01

    This thesis presents data on internally and externally received doses for radiation workers whose records are kept at the Safety Office of the University of Surrey for the period 1981-1990. The distribution of doses by range is presented and analysed. The patterns of the collective equivalent dose (CED) and the average individual equivalent dose (IED) over the 10-year period are presented. The annual CED is very low, so that even the total for the 10-year period is less than 1 man-Sv. Likewise, the annual average IED is extremely low, well below the average annual dose to the U.K. population from overall sources of ionising radiation. Some relevant aspects of the 1990 ICRP Recommendations are examined and the impact of these to the 'practices' and sources of ionising radiation in the University is given consideration. The results of the 10-year review provide more evidence of over designation of radiation workers in the University. A recommendation is made to reduce the number of workers who are routinely monitored and justification and options are presented. This study is viewed as a useful database which could be of particular importance in the procedure of optimisation of radiation protection in the University of Surrey and U.K. establishments for higher education as a whole. (author)

  3. Columbia physics in the fifties: Untold tales

    Directory of Open Access Journals (Sweden)

    J. Sucher

    2000-07-01

    Full Text Available Eyvind Wichmann and I were both graduate students at Columbia University in the fifties, a decade of remarkable creativity by a star-studded physics faculty, which included some ten Nobel Laureates. I share some reminiscences about our time there and explain the role played in our relationship by an eightball.

  4. German Atomic Energy Act turns fifty

    International Nuclear Information System (INIS)

    Schneider, Horst

    2009-01-01

    The German Atomic Energy Act entered into force on January 1, 1960. It turns fifty at the beginning of 2010. Is this a reason to celebrate or rather the opposite? Lawyers, in principle, can view old pieces of legislation from 2 perspectives: On the one hand, aged laws are treated in a spirit of veneration and are celebrated as proven. On the other hand, an anniversary of this kind can be a welcome reason for demands to abolish or, at least, fundamentally renew that law. Over the past half century, the German Atomic Energy Act went through stormy and varied phases both of a legal and a political character. Its 50 th anniversary is likely to spark off very conflicting evaluations as well. A review of legal history shows that the German or, rather, the Federal German Atomic Energy Act (AtG) was not a first-of-its-kind piece of legislation but stemmed from the 1957 EURATOM Treaty, in a way representing a latecomer of that treaty. The Atomic Energy Act experienced a number of important developments throughout its history: - In 1975, compulsory licensing of fuel element factories was introduced. - The back end of the fuel cycle, especially final storage, were incorporated in the Atomic Energy Act comprehensively first in 1976. - In 1985, legislators decided in favor of unlimited nuclear liability. - In 1994 and 1998, only some innovations in special items were introduced under the headings of environmental impact assessment and suitability for repository storage because the controversy about nuclear power did not permit a fundamental alignment towards a more comprehensive modern safety law. - The decision to opt out of the peaceful uses of nuclear power in 2002 drew the final line so far of decisions about directions of nuclear law in a major amendment. In parallel, the decisions by the Federal Constitutional Court and the Federal Administrative Court in the late 1970s and, above all, the 1980s provided important assistance which has remained valid to this day. What is

  5. Early experience with dual mobility acetabular systems featuring highly cross-linked polyethylene liners for primary hip arthroplasty in patients under fifty five years of age: an international multi-centre preliminary study.

    Science.gov (United States)

    Epinette, Jean-Alain; Harwin, Steven F; Rowan, Fiachra E; Tracol, Philippe; Mont, Michael A; Chughtai, Morad; Westrich, Geoffrey H

    2017-03-01

    To evaluate early performance of contemporary dual mobility acetabular systems with second generation annealed highly cross-linked polyethylene for primary hip arthroplasty of patients under 55 years of age. A prospective observational five years study across five centers in Europe and the USA of 321 patients with a mean age of 48.1 years was performed. Patients were assessed for causes of revision, hip instability, intra-prosthetic dissociation, Harris hip score and radiological signs of osteolysis. There were no dislocations and no intra-prosthetic dissociations. Kaplan Meier analysis demonstrated 97.51% survivorship for all cause revision and 99.68% survivorship for acetabular component revision at five years. Mean Harris hip score was 93.6. Two acetabular shells were revised for neck-rim implant impingement without dislocation and ten femoral stems were revised for causes unrelated to dual mobility implants. Contemporary highly cross-linked polyethylene dual mobility systems demonstrate excellent early clinical, radiological, and survivorship results in a cohort of patients that demand high performance from their implants. It is envisaged that DM and second generation annealed HXLPE may reduce THA instability and wear, the two most common causes of THA revision in hip arthroplasty.

  6. Comparison of ESD and major organ absorbed doses of 5 year old standard guidekines and clinical exposure conditions

    Energy Technology Data Exchange (ETDEWEB)

    Kang, A Ram; Ahn, Sung Min [Dept. of Radiological Science, The Graduate School, Gachon University, Incheon (Korea, Republic of); Lee, In Ja [Dept. of Radiologic technology, Dongnam health University, Suwon (Korea, Republic of)

    2017-09-15

    Pediatrics are more sensibility to radiation than adults and because they are organs that are not completely grown, they have a life expectancy that can be adversely affected by exposure. Therefore, the management of exposure dose is more important than the case of adult. The purpose of this study was to determine the suitability of the 10 year old phantom for the 5 year old pediatric's recommendation and the incident surface dose, and to measure the organ absorbed dose. This study is compared the organ absorbed dose and the entrance surface dose in the clinical conditions at 5 and 10 years old pediatric. Clinical 5 year old condition was slightly higher than recommendation condition and 10 year old condition was very high. In addition, recommendation condition ESD was found to be 43% higher than the ESD of the 5 year old group and the ESD of the 10 year old group was 126% higher than that of the 5 year old group. The recommended ESD at 5 years old and the ESD according to clinical imaging conditions were 31.6%. There was no significant difference between the 5 year old recommended exposure conditions and the organ absorbed dose due to clinical exposure conditions, but there was a large difference between the Chest and Pelvic. However, it was found that there was a remarkable difference when comparing the organ absorbed dose by 10 year clinical exposure conditions. Therefore, more detailed standard exposure dose for the recommended dose of pediatric should be studied.

  7. Comparison of ESD and major organ absorbed doses of 5 year old standard guidekines and clinical exposure conditions

    International Nuclear Information System (INIS)

    Kang, A Ram; Ahn, Sung Min; Lee, In Ja

    2017-01-01

    Pediatrics are more sensibility to radiation than adults and because they are organs that are not completely grown, they have a life expectancy that can be adversely affected by exposure. Therefore, the management of exposure dose is more important than the case of adult. The purpose of this study was to determine the suitability of the 10 year old phantom for the 5 year old pediatric's recommendation and the incident surface dose, and to measure the organ absorbed dose. This study is compared the organ absorbed dose and the entrance surface dose in the clinical conditions at 5 and 10 years old pediatric. Clinical 5 year old condition was slightly higher than recommendation condition and 10 year old condition was very high. In addition, recommendation condition ESD was found to be 43% higher than the ESD of the 5 year old group and the ESD of the 10 year old group was 126% higher than that of the 5 year old group. The recommended ESD at 5 years old and the ESD according to clinical imaging conditions were 31.6%. There was no significant difference between the 5 year old recommended exposure conditions and the organ absorbed dose due to clinical exposure conditions, but there was a large difference between the Chest and Pelvic. However, it was found that there was a remarkable difference when comparing the organ absorbed dose by 10 year clinical exposure conditions. Therefore, more detailed standard exposure dose for the recommended dose of pediatric should be studied

  8. Dose response in prostate cancer with 8-12 years' follow-up

    International Nuclear Information System (INIS)

    Hanks, Gerald E.; Hanlon, Alexandra L.; Epstein, Barry; Horwitz, Eric M.

    2002-01-01

    Purpose: This communication reports the long-term results of the original group of prostate cancer patients who participated in the first prospective Fox Chase Cancer Center radiation dose escalation study for which 8-12 years of follow-up is now available. Methods and Materials: Between March 1, 1989 and October 31, 1992, 232 patients with clinically localized prostate cancer received three-dimensional conformal radiotherapy only at Fox Chase Cancer Center in a prospective dose-escalation study. Of these patients, 229 were assessable. The 8-, 10-, and 12-year actuarial rates of biochemical control (biochemically no evidence of disease [bNED]), freedom from distant metastasis (FDM), and morbidity were calculated. The Cox proportional hazards model was used to assess multivariately the predictors of bNED control and FDM, including pretreatment prostate-specific antigen (PSA) level (continuous), tumor stage (T1/T2a vs. T2b/T3), Gleason score (2-6 vs. 7-10), and radiation dose (continuous). The median total dose for all patients was 74 Gy (range 67-81). The median follow-up for living patients was 110 months (range 89-147). bNED control was defined using the American Society for Therapeutic Radiology and Oncology consensus definition. Results: The actuarial bNED control for all patients included in this series was 55% at 5 years, 48% at 10 years, and 48% at 12 years. Patients with pretreatment PSA levels of 10-20 ng/mL had statistically significant differences (19% vs. 31% vs. 84%, p=0.0003) in bNED control when stratified by dose ( 75.6 Gy, respectively) on univariate analysis. For the 229 patients with follow-up, 124 (54%) were clinically and biochemically without evidence of disease. Sixty-nine patients were alive at the time of last follow-up, and 55 patients were dead of intercurrent disease. On multivariate analysis, radiation dose was a statistically significant predictor of bNED control for all patients and for unfavorable patients with a pretreatment PSA 20

  9. Dose escalation with 3D conformal treatment: five year outcomes, treatment optimization, and future directions

    International Nuclear Information System (INIS)

    Hanks, Gerald E.; Hanlon, Alexandra L. M.S.; Schultheiss, Timothy E.; Pinover, Wayne H.; Movsas, Benjamin; Epstein, Barry E.; Hunt, Margie

    1998-01-01

    Purpose: To report the 5-year outcomes of dose escalation with 3D conformal treatment (3DCRT) of prostate cancer. Methods and Materials: Two hundred thirty-two consecutive patients were treated with 3DCRT alone between 6/89 and 10/92 with ICRU reporting point dose that increased from 63 to 79 Gy. The median follow-up was 60 months, and any patient free of clinical or biochemical evidence of disease was termed bNED. Biochemical failure was defined as prostate-specific antigen (PSA) rising on two consecutive recordings and exceeding 1.5 ng/ml. Morbidity was reported by the Radiation Therapy Oncology Group (RTOG) scale, the Late Effects Normal Tissue (LENT) scale, and a Fox Chase modification of the latter (FC-LENT). All patients were treated with a four-field technique with a 1 cm clinical target volume (CTV) to planning target volume (PTV) margin to the prostate or prostate boost; the CTV and gross tumor volume (GTV) were the same. Actuarial rates of outcome were calculated by Kaplan-Meier and cumulative incidence methods and compared using the log rank and Gray's test statistic, respectively. Cox regression models were used to establish prognostic factors predictive of the various measures of outcome. Five-year Kaplan-Meier bNED rates were utilized by dose group to estimate logit response models for bNED and late morbidity. Results: PSA 10 ng/ml based on 5-year bNED results. No dose response was observed for patients with pretreatment PSA 10 ng/ml strongly suggests that clinical trials employing radiation should investigate the use of 3DCRT and prostate doses of 76-80 Gy

  10. Radiation dose from food to man the first four years after Chernobyl

    International Nuclear Information System (INIS)

    Boee, E.; Strand, P.; Selnaes, T.D.

    1991-01-01

    In order to estimate the degree to which the Norwegian population was exposed to radiation as a consequence of the Chernobyl accident, four population groups were selected in 1987. Two groups encompassed individuals who were assumed to consume relatively large amounts of foods containing high levels of radionuclides. Two other groups included randomly selected people from two different districts. Two methods, dietary studies and whole-body measurements, were used to estimate the dose burden to which the participants had been exposed. The intake of radionuclides via food during the course of a year was estimated by dietary studies, while whole-body measurements were performed on people once a year to determine body reactivity levels. The annual dose was calculated on the basis of data gathered from the two types of study. The investigational period was March to May in 1987 to 1990. There was good correlation between doses estimated on the basis of dietary studies on the one hand and whole-body measurements on the other. Nevertheless, there was a two-fold difference in the size of the dose estimated by the two methods. The average annual radiocesium intake by the Norwegian population has been between 10000 and 25000 Bq, milk been the major source in the years following the accident. Dietary advice, together with agricultural decontamination measures, have resulted in considerable reduction in the level of exposure in the population. The study also demonstrated that changes in dietary habits have led to a dramatic dose reduction in the specially selected groups. 8 refs., 7 figs., 22 tabs

  11. Development and use of a fifteen year-old equivalent mathematical phantom for internal dose calculations

    International Nuclear Information System (INIS)

    Jones, R.M.; Poston, J.W.; Hwang, J.L.; Jones, T.D.; Warner, G.G.

    1976-06-01

    The existence of a phantom based on anatomical data for the average fifteen-year-old provides for a proficient means of obtaining estimates of absorbed dose for children of that age. Dimensions representative of an average fifteen-year-old human, obtained from various biological and medical research, were transformed into a mathematical construct of idealized shapes of the exterior, skeletal system, and internal organs of a human. The idealization for an average adult presently in use by the International Commission on Radiological Protection was used as a basis for design. The mathematical equations describing the phantom were developed to be readily adaptable to present-day methods of dose estimation. Typical exposure situations in nuclear medicine have previously been modeled for existing phantoms. With no further development of the exposure model necessary, adaptation to the fifteen-year-old phantom demonstrated the utility of the design. Estimates of absorbed dose were obtained for the administration of two radiopharmaceuticals, /sup 99m/Tc-sulfur colloid and /sup 99m/Tc-DMSA

  12. Age- and gender-specific estimates of cumulative CT dose over 5 years using real radiation dose tracking data in children

    International Nuclear Information System (INIS)

    Lee, Eunsol; Goo, Hyun Woo; Lee, Jae-Yeong

    2015-01-01

    It is necessary to develop a mechanism to estimate and analyze cumulative radiation risks from multiple CT exams in various clinical scenarios in children. To identify major contributors to high cumulative CT dose estimates using actual dose-length product values collected for 5 years in children. Between August 2006 and July 2011 we reviewed 26,937 CT exams in 13,803 children. Among them, we included 931 children (median age 3.5 years, age range 0 days-15 years; M:F = 533:398) who had 5,339 CT exams. Each child underwent at least three CT scans and had accessible radiation dose reports. Dose-length product values were automatically extracted from DICOM files and we used recently updated conversion factors for age, gender, anatomical region and tube voltage to estimate CT radiation dose. We tracked the calculated CT dose estimates to obtain a 5-year cumulative value for each child. The study population was divided into three groups according to the cumulative CT dose estimates: high, ≥30 mSv; moderate, 10-30 mSv; and low, <10 mSv. We reviewed clinical data and CT protocols to identify major contributors to high and moderate cumulative CT dose estimates. Median cumulative CT dose estimate was 5.4 mSv (range 0.5-71.1 mSv), and median number of CT scans was 4 (range 3-36). High cumulative CT dose estimates were most common in children with malignant tumors (57.9%, 11/19). High frequency of CT scans was attributed to high cumulative CT dose estimates in children with ventriculoperitoneal shunt (35 in 1 child) and malignant tumors (range 18-49). Moreover, high-dose CT protocols, such as multiphase abdomen CT (median 4.7 mSv) contributed to high cumulative CT dose estimates even in children with a low number of CT scans. Disease group, number of CT scans, and high-dose CT protocols are major contributors to higher cumulative CT dose estimates in children. (orig.)

  13. Five-Year Outcomes of High-Dose Single-Fraction Spinal Stereotactic Radiosurgery

    International Nuclear Information System (INIS)

    Moussazadeh, Nelson; Lis, Eric; Katsoulakis, Evangelia; Kahn, Sweena; Svoboda, Marek; DiStefano, Natalie M.; McLaughlin, Lily; Bilsky, Mark H.; Yamada, Yoshiya; Laufer, Ilya

    2015-01-01

    Purpose: To characterize local tumor control and toxicity risk in very long-term survivors (>5 years) after high-dose spinal image guided, intensity modulated radiation therapy delivered as single-dose stereotactic radiosurgery (SRS). Previously published spinal SRS outcome analyses have included a heterogeneous population of cancer patients, mostly with short survival. This is the first study reporting the long-term tumor control and toxicity profiles after high-dose single-fraction spinal SRS. Methods and Materials: The study population included all patients treated from June 2004 to July 2009 with single-fraction spinal SRS (dose 24 Gy) who had survived at least 5 years after treatment. The endpoints examined included disease progression, surgical or radiation retreatment, in-field fracture development, and radiation-associated toxicity, scored using the Radiation Therapy Oncology Group radiation morbidity scoring criteria and the Common Terminology Criteria for Adverse Events, version 4.0. Local control and fracture development were assessed using Kaplan-Meier analysis. Results: Of 278 patients, 31 (11.1%), with 36 segments treated for spinal tumors, survived at least 5 years after treatment and were followed up radiographically and clinically for a median of 6.1 years (maximum 102 months). The histopathologic findings for the 5-year survivors included radiation-resistant metastases in 58%, radiation-sensitive metastases in 22%, and primary bone tumors in 19%. In this selected cohort, 3 treatment failures occurred at a median of 48.6 months, including 2 recurrences in the radiation field and 1 patient with demonstrated progression at the treatment margins. Ten lesions (27.8%) were associated with acute grade 1 cutaneous or gastrointestinal toxicity. Delayed toxicity ≥3 months after treatment included 8 cases (22.2%) of mild neuropathy, 2 (5.6%) of gastrointestinal discomfort, 8 (22.2%) of dermatitides, and 3 (8.3%) of myalgias/myositis. Thirteen

  14. Five-Year Outcomes of High-Dose Single-Fraction Spinal Stereotactic Radiosurgery

    Energy Technology Data Exchange (ETDEWEB)

    Moussazadeh, Nelson [Division of Neurological Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York (United States); Lis, Eric [Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Katsoulakis, Evangelia [Department of Radiation Oncology, New York Methodist Hospital, Brooklyn, New York (United States); Kahn, Sweena; Svoboda, Marek; DiStefano, Natalie M.; McLaughlin, Lily [Division of Neurological Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Bilsky, Mark H. [Division of Neurological Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York (United States); Yamada, Yoshiya [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Laufer, Ilya, E-mail: lauferi@mskcc.org [Division of Neurological Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, New York (United States)

    2015-10-01

    Purpose: To characterize local tumor control and toxicity risk in very long-term survivors (>5 years) after high-dose spinal image guided, intensity modulated radiation therapy delivered as single-dose stereotactic radiosurgery (SRS). Previously published spinal SRS outcome analyses have included a heterogeneous population of cancer patients, mostly with short survival. This is the first study reporting the long-term tumor control and toxicity profiles after high-dose single-fraction spinal SRS. Methods and Materials: The study population included all patients treated from June 2004 to July 2009 with single-fraction spinal SRS (dose 24 Gy) who had survived at least 5 years after treatment. The endpoints examined included disease progression, surgical or radiation retreatment, in-field fracture development, and radiation-associated toxicity, scored using the Radiation Therapy Oncology Group radiation morbidity scoring criteria and the Common Terminology Criteria for Adverse Events, version 4.0. Local control and fracture development were assessed using Kaplan-Meier analysis. Results: Of 278 patients, 31 (11.1%), with 36 segments treated for spinal tumors, survived at least 5 years after treatment and were followed up radiographically and clinically for a median of 6.1 years (maximum 102 months). The histopathologic findings for the 5-year survivors included radiation-resistant metastases in 58%, radiation-sensitive metastases in 22%, and primary bone tumors in 19%. In this selected cohort, 3 treatment failures occurred at a median of 48.6 months, including 2 recurrences in the radiation field and 1 patient with demonstrated progression at the treatment margins. Ten lesions (27.8%) were associated with acute grade 1 cutaneous or gastrointestinal toxicity. Delayed toxicity ≥3 months after treatment included 8 cases (22.2%) of mild neuropathy, 2 (5.6%) of gastrointestinal discomfort, 8 (22.2%) of dermatitides, and 3 (8.3%) of myalgias/myositis. Thirteen

  15. Three years of seasonal dose assessment from outdoors gamma exposure in Sao Paulo city, Brazil

    International Nuclear Information System (INIS)

    Carneiro, Janete C.G.G.; Sanches, Matias P.; Betti, Flavio; Pecequilo, Brigitte R.S.

    2011-01-01

    Measurements of external (outdoors) gamma exposure from natural background radiation have been used to estimate the average annual doses in Sao Paulo city. Twelve monitoring stations were placed in different regions of the town including both urban (where building materials are present) and outskirts areas. Seasonally surveys observing the four seasons from 2008 to 2010 have been carried out. The data were drawn from a 3-month sampling using the thermoluminescent dosimetry. The effective doses values are quite similar (slightly higher during the winter), so it can be considered that these results are not under significant influence (or variability) of seasonal environmental conditions like temperature, wind or rain. Dose values over the three years period, from Vila Carrao district, exclusively an urban location with mostly no green areas, present the highest values, while the lower values were always obtained for Tucuruvi district, near the biggest urban forest, Parque Estadual da Cantareira. Over the assessed period, the mean of the average annual effective doses was 1.3 ± 0.1 mSv.y -1 . For the same period, the average annual background from nuclear and radioactive facility at IPEN was 0.75 ± 0.12 mSv.y -1 . (author)

  16. Pulsed dose rate brachytherapy (PDR): an analysis of the technique at 2 years

    Energy Technology Data Exchange (ETDEWEB)

    Thienpont, M [Ghent Rijksuniversiteit (Belgium). Kliniek voor Radiotherapie en Kerngeneeskunde; Van Eijkeren, M; Van Hecke, H; Boterberg, T; De Neve, W

    1995-12-01

    A total of 154 applications was analysed using a pulsed dose brachytherapy technique for 138 patients over a 2 year period with emphasis on technical aspects influencing the overall treatment time. Vaginal ovoids were used in 59 cases, plastic tubes in 52, a Fletcher-type in 18, vaginal cylinders in 14 and a perineal template in 11 cases. Pulses were given at hourly intervals with a median dose rate of 0.6 Gy per pulse (range 0.4 to 3 Gy). The number of pulses per application varied from 3 to 134 (median 32). The number of dwell positions varied from 1 to 542 over 1 to 18 catheters. Patient related problems were few. The room was entered almost every 77 minutes. We noted 561 status codes in 147 applications. Of the 25 different codes, the most frequent one was due to the door left open when a pulse had to be given (35%) or due to constriction of the plastic catheters at the transfer tube junction (26%). However, the median total treatment time was increased by only 5 minutes. With pulsed dose rate brachytherapy at hourly pulses we can treat our patients within the planned time despite frequent room entrance and occurrence of an appreciable number of status codes. This technique seems to fulfill its promise to replace low dose rate brachytherapy.

  17. Three years of seasonal dose assessment from outdoors gamma exposure in Sao Paulo city, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Janete C.G.G.; Sanches, Matias P.; Betti, Flavio; Pecequilo, Brigitte R.S., E-mail: janetegc@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-07-01

    Measurements of external (outdoors) gamma exposure from natural background radiation have been used to estimate the average annual doses in Sao Paulo city. Twelve monitoring stations were placed in different regions of the town including both urban (where building materials are present) and outskirts areas. Seasonally surveys observing the four seasons from 2008 to 2010 have been carried out. The data were drawn from a 3-month sampling using the thermoluminescent dosimetry. The effective doses values are quite similar (slightly higher during the winter), so it can be considered that these results are not under significant influence (or variability) of seasonal environmental conditions like temperature, wind or rain. Dose values over the three years period, from Vila Carrao district, exclusively an urban location with mostly no green areas, present the highest values, while the lower values were always obtained for Tucuruvi district, near the biggest urban forest, Parque Estadual da Cantareira. Over the assessed period, the mean of the average annual effective doses was 1.3 {+-} 0.1 mSv.y{sup -1}. For the same period, the average annual background from nuclear and radioactive facility at IPEN was 0.75 {+-} 0.12 mSv.y{sup -1}. (author)

  18. Fifty challenging problems in probability with solutions

    CERN Document Server

    Mosteller, Frederick

    1987-01-01

    Can you solve the problem of ""The Unfair Subway""? Marvin gets off work at random times between 3 and 5 p.m. His mother lives uptown, his girlfriend downtown. He takes the first subway that comes in either direction and eats dinner with the one he is delivered to. His mother complains that he never comes to see her, but he says she has a 50-50 chance. He has had dinner with her twice in the last 20 working days. Explain. Marvin's adventures in probability are one of the fifty intriguing puzzles that illustrate both elementary ad advanced aspects of probability, each problem designed to chall

  19. Fifty Years of A-Level Mathematics: Have Standards Changed?

    Science.gov (United States)

    Jones, Ian; Wheadon, Chris; Humphries, Sara; Inglis, Matthew

    2016-01-01

    Advanced-level (A-level) mathematics is a high-profile qualification taken by many school leavers in England, Wales, Northern Ireland and around the world as preparation for university study. Concern has been expressed in these countries that standards in A-level mathematics have declined over time, and that school leavers enter university or the…

  20. Tribology - friction, lubrication and wear: fifty years on. 2 v

    International Nuclear Information System (INIS)

    1987-01-01

    The paper presents the proceedings of the International Tribology Conference held in London (United Kingdom), 1987, and organised by the Institution of Mechanical Engineers. The aim of the conference was to address the current status and future developments in all aspects of tribology. The conference proceedings contained 121 papers, and the sessions were structured under six headings: hydrodynamic, elastohydrodynamic and mixed lubrication; friction and wear; contact mechanics; materials; design and applications; and lubricants. Four papers were chosen for INIS and indexed separately. (U.K.)

  1. Theoretical nuclear fission: The evolution of the first fifty years

    International Nuclear Information System (INIS)

    Griffin, J.J.

    1989-01-01

    The evolution of the dynamical theory of nuclear fission is reviewed through four recognizable major phases. Its conceptual structure was from the outset shaped by the Bohr-Wheeler idea of the nucleus as a liquid drop. On the other hand, today's nuclear drop is a system which has under study repeatedly revealed remarkable and unexpected properties, especially with respect to the dependence of its energy upon its shape. Although some of these special properties arise from quantal effects, the theory of fission is still expressed largely in terms of classical dynamics. This situation leaves open the question whether our theoretical success flows entirely from physical truth or in part from the great phenomenological flexibility of the drop model. It leads one also to wonder whether in the next phase connections with the quantal many-body dynamics might finally find a firm place in the theory, and tie its predictions quantitatively to the deeper microscopic reality

  2. Fifty years of CFD for room air distribution

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm

    2015-01-01

    the principle behind CFD, the development in numerical schemes, turbulence models and the importance of the increased computer size since the 1970s. Special attention is given to the selection of the correct governing equations, to the understanding of low turbulent flow, to the selection of turbulence models...

  3. MAYAK production association ``the fifty year old secret''

    Science.gov (United States)

    Chikshov, A. I.; Glagolenko, Y. V.; Malykh, Y. A.; Langley, Roger; Latham, Ian

    1998-06-01

    This paper details the history, production capability, facilities and capacity of MAYAK Production Association. The paper also gives technical details of reactors, storage ponds and handling facilities used for fabrication of Co-60 and Cs-137 sources for Gamma Irradiation Plants and other applications, and describes the quality assurance system and methods.

  4. The lure of local SETI: Fifty years of field experiments

    Science.gov (United States)

    Ailleris, Philippe

    2011-01-01

    With the commemoration in October 2007 of the Sputnik launch, space exploration celebrated its 50th anniversary. Despite impressive technological and scientific achievements the fascination for space has weakened during the last decades. One contributing factor has been the gradual disappearance of mankind's hope of discovering extraterrestrial life within its close neighbourhood. In striking contrast and since the middle of the 20th century, a non-negligible proportion of the population have already concluded that intelligent beings from other worlds do exist and visit Earth through space vehicles popularly called Unidentified Flying Objects (UFOs). In light of the continuous public interest for the UFO enigma symbolized by the recent widely diffused media announcements on the release of French and English governmental files; and considering the approach of broadening the strategies of the "Active SETI" approach and the existence of a rich multi-disciplinary UFO documentation of potential interest for SETI; this paper describes some past scientific attempts to demonstrate the physical reality of the phenomena and potentially the presence on Earth of probes of extraterrestrial origin. Details of the different instrumented field studies deployed by scientists and organizations during the period 1950-1990 in the USA, Canada and Europe are provided. In conclusion it will be argued that while continuing the current radio/optical SETI searches, there is the necessity to maintain sustaining attention to the topic of anomalous aerospace phenomena and to develop new rigorous research approaches.

  5. International conference on fifty years research in nuclear fission

    International Nuclear Information System (INIS)

    1989-02-01

    These proceedings contain extended abstracts of the papers presented at the named conference. They deal with static properties of fission, instrumentation for fission studies, fission in compound-nucleus reactions, fission dynamics, fission-like heavy ion reactions, and fusion reactions. See hints under the relevant topics. (HSI)

  6. Fifty years of illumination about the natural levels of adaptation

    DEFF Research Database (Denmark)

    Boomsma, Jacobus Jan

    2016-01-01

    A visionary Darwinian ahead of his time, George C. Williams developed in his 1966 book Adaptation and Natural Selection the essentials of a unifying theory of adaptation that remains robust today and has inspired immense progress in understanding how natural selection works.......A visionary Darwinian ahead of his time, George C. Williams developed in his 1966 book Adaptation and Natural Selection the essentials of a unifying theory of adaptation that remains robust today and has inspired immense progress in understanding how natural selection works....

  7. Fifty years of forest hydrology in the Southeast

    Science.gov (United States)

    C. Rhett Jackson; Ge Sun; Devendra Amatya; Wayne T. Swank; Mark Riedel; Jim Patric; Tom Williams; Jim M. Vose; Carl Trettin; W. Michael Aust; R. Scott Beasley; Hamlin Williston; George G. Ice

    2004-01-01

    The forests of the southeastern United States are incredibly valuable and diverse, both for timber production and for the aquatic habitat they provide. These overlapping values and diverse conditions have spawned numerous studies to assess how forest management affects hydrology and water quality. In the mountains, key watershed studies include those conducted at USDA...

  8. [Fifty years of green memory: nursing care for the environment].

    Science.gov (United States)

    Wächter, Maria Isaura Fradera; Piccinini, Gema Conte; Matzenbacher, Nelson Ivo

    2003-08-01

    This paper describes the activities related to the 50th anniversary celebration of the Nursing School of the Federal University of Rio Grande do Sul, Brazil. It aimed at surveying the trees of the florula of the green area that surrounds the School and rescuing the memory of those who planted each specimen. The orphan trees were offered to the teaching and administrative staff for adoption. Adding up the erva-mate and the pau-brasil trees planted during the celebration, there are a total of 100 trees distributed into 18 families and 29 species out of which 15 are native and 14 are exotic trees. The erva-mate tree and its monument represent the landmark of this significant date.

  9. Metallography at the Met Lab -- The first fifty years

    International Nuclear Information System (INIS)

    Lee, R.H.

    1995-01-01

    The Met Lab at the University of Chicago was established to build the world's first nuclear reactor. The object was to see if a pile (CP-1) could be built to create a sustained chain reaction, i.e., controlled nuclear fission. New materials of the very best quality were needed and people of many skills worked together to achieve the goal as quickly as possible. This is the story of a select group of people who were scientific and engineering pioneers in this new field. Research continued at new sites on more advanced reactors and cooling systems. Many problems were encountered in the fabrication of reactor components, and metallography was a crucial method of analyzing the reactions and quality of consolidation. 1996 will be the 50th anniversary of the beginning of the National Laboratories, so it is appropriate to commemorate and recall some pioneering achievements

  10. Maternal health in fifty years of Tanzania independence: Challenges ...

    African Journals Online (AJOL)

    High rate of maternal death is one of the major public health concerns in Tanzania. ... had been on a downward trend from 453 to 200 per 100,000 live births. ... Current statistics indicate that maternal mortality ratio has dropped slightly in 2010 ...

  11. Fifty years of studies on environmental radioactivity in Peru

    International Nuclear Information System (INIS)

    Osores, Jose M.; Gonzales, Susana; Martinez, Jorge; Lopez, Edith; Jara, Raul; Anaya, Aurelio

    2008-01-01

    In May of 1962, due to the explosions carried out by the Commission of Atomic Energy of the United States in the Christmas Island, a group of professionals of the 'Junta de Control de Energia Atomica' of Peru, created in 1957, carried out experimental evaluations of atmospheric radioactivity, obtaining acceptable results regarding those of Naval US Research Laboratory, this was the beginning of the Laboratory of Atmospheric Radioactivity that begins to operate permanently in February of 1964. In 1966, France began a program of nuclear tests in the French Polynesian, generating concern due to the meteorological conditions that could affect the peruvian population. With the support of experts and equipments on the part of the government from France, the Laboratory of Environmental Radioactivity began their activities in August of 1966. At the present time, the Laboratory of Environmental Radioactivity is located in the Nuclear Center RACSO of the 'Instituto Peruano de Energia Nuclear' and it carries out the following programs: Radiological Environmental Surveillance in the Influence Area of the Nuclear Center, Nationwide Radiological Environmental Surveillance, Marine Radiological Environmental Surveillance, Radiological Environmental Surveillance in the Peruvian Antarctic Region and Surveillance of the Radioactive Contamination of Foods. The results of the evaluations of the programs of radiological environmental surveillance, developed nationwide from 1962, show one gradual decrease of the levels of environmental radioactivity. Significant concentrations of Cs-137 and Be-7 were found in the Antarctic region, and, in the area of influence of the nuclear center RACSO, environmental discharges of I-131, Cs-137, Co-60, Cs- 134 and Te-123m were detected, however, the concentrations did not present radiological risk for the population. (author)

  12. History for fifty years of Korea Atomic Energy Research Institute

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-15

    This introduces establishment, foundation, technical independent, puberty and preview of KAERI. It is divided six chapters, which deals with research and development on nuclear fission and nuclear fusion, cycle of nuclear fuel and research of nuclear safety, nuclear business and technical development, activity on nuclear safe regulation like establishment and role module for nuclear safety center and check of the safety of nuclear power plant, study of radio therapeutics and cancer treatment, development of human resources for nuclear power and training, general management about regulations, organization, person, contract, facility and building, welfare and establishment and activity of labor union.

  13. Fifty-year study of the Peierls-Nabarro stress

    CSIR Research Space (South Africa)

    Nabarro, FRN

    1997-08-30

    Full Text Available , North-Holland, Amsterdam, 1979, pp. 33. [9] E. Orowan, in: Cyril Stanley Smith (Ed.), The Sorby Centennial Symposium on the History of Metallurgy, Gordon and Breach, New York, 1965, pp. 359. [lo] R.E. Peierls, in: A...

  14. Fifty years of oxacalix[3]arenes: A review

    Directory of Open Access Journals (Sweden)

    Kevin Cottet

    2012-02-01

    Full Text Available Hexahomotrioxacalix[3]arenes, commonly called oxacalix[3]arenes, were first reported in 1962. Since then, their chemistry has been expanded to include numerous derivatives and complexes. This review describes the syntheses of the parent compounds, their derivatives, and their complexation behaviour towards cations. Extraction data are presented, as are crystal structures of the macrocycles and their complexes with guest species. Applications in fields as diverse as ion selective electrode modifiers, fluorescence sensors, fullerene separations and biomimetic chemistry are described.

  15. The Sociological Imagination and Its Promise Fifty Years Later

    Directory of Open Access Journals (Sweden)

    Carlos Frade

    2009-11-01

    Full Text Available This paper offers a restatement of Wright Mills’ The Sociological Imagination and tries to judge whether its promise can be credibly renewed today by addressing the question about the present and future possibilities of the social sciences as free forms of enquiry. Relying on Weber, Mills and other thinkers, the paper sustains that the possibilities for a truly free social science essentially depend on three major ‘conditions’: the subjective stance or vocation, the sociological imagination proper, and an independent social science politics, conditions whose apt names can also be ‘love’, ‘insight’ and ‘courage’. An analysis of the presence and strength of each of these conditions in contemporary social science and in academia shows the magnitude of the task faced for the existence of a free social science.

  16. Hashing in computer science fifty years of slicing and dicing

    CERN Document Server

    Konheim, Alan G

    2009-01-01

    Written by one of the developers of the technology, Hashing is both a historical document on the development of hashing and an analysis of the applications of hashing in a society increasingly concerned with security. The material in this book is based on courses taught by the author, and key points are reinforced in sample problems and an accompanying instructor s manual. Graduate students and researchers in mathematics, cryptography, and security will benefit from this overview of hashing and the complicated mathematics that it requires

  17. Fifty-four Years of Adventures in Infrared Astronomy

    Science.gov (United States)

    Becklin, Eric Eric

    2018-01-01

    My adventures in infrared astronomy started when I was a grad student in 1965 with the discovery of an infrared-bright object (now known as the Becklin-Neugebauer Object) in the Orion Nebula. In 1966, I made the first measurements of the infrared radiation from the center of the Milky Way Galaxy. I was fortunate enough to be able to take advantage of the 2.2 micron sky survey carried out by Neugebauer and Leighton (1969), which produced many remarkable discoveries, the most spectacular being the heavily dust-embedded carbon star IRC+10216, thebrightest object in the sky at 5 microns outside the solar system. In the 1970’s there was a growth in Infrared astronomy with the availability of many new facilities such as the Kuiper Airborne Observatory, (KAO) which I used extensively with Mike Werner and Ian Gatley for many unique observations. In 1977, I moved to Hawaii to work on the NASA IRTF 3- meter telescope. Many discoveries were made, including the first direct measurements of the rings of Jupiter at 2.2 microns (with Gareth Wynn-Williams) and the discovery of the first L dwarf star around a white dwarf (with Ben Zuckerman). In the 1980’s the introduction of large format arrays changed the way we did infrared astronomy. With Ian McLean, I moved to UCLA in 1990 to start the IR lab and get involved in Keck development and science. In 1995, Andrea, Ghez, Mark Morris and I started looking for evidence of a possible massive Black Hole in the Galactic Center. Spectacular observations using the Keck10 meter telescopes with large format near-infrared arrays and adaptive optics led to the confirmation of the presence of such a black hole and an estimate of its mass (4xE6 M (Sun)). In 1996, I began working on the Stratospheric Observatory For Infrared Astronomy (SOFIA) and I will finish my talk by discussing SOFIA observations of the ring of dust and gas orbiting the massive black hole in the center

  18. Fifty-one years of Los Alamos Spacecraft

    Energy Technology Data Exchange (ETDEWEB)

    Fenimore, Edward E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-09-04

    From 1963 to 2014, the Los Alamos National Laboratory was involved in at least 233 spacecraft. There are probably only one or two institutions in the world that have been involved in so many spacecraft. Los Alamos space exploration started with the Vela satellites for nuclear test detection, but soon expanded to ionospheric research (mostly barium releases), radioisotope thermoelectric generators, solar physics, solar wind, magnetospheres, astrophysics, national security, planetary physics, earth resources, radio propagation in the ionosphere, and cubesats. Here, we present a list of the spacecraft, their purpose, and their launch dates for use during RocketFest

  19. Fifty Years of Institutional Rehabilitation Outcomes: Inventory and Implications.

    Science.gov (United States)

    Gibson, David; Fields, Donald L.

    1983-01-01

    Temporal variability within the record was more easily attributed to the adequacy of past accountability research and to public policy than to program effects, socioeconomic climate, or changing receiver group attitudes. (Author/SEW)

  20. Fifty years later - still not enough early external involvement

    International Nuclear Information System (INIS)

    Lash, T.

    1992-01-01

    When it comes to nuclear issues, public participation is like the weather: We talk a lot but we do not do anything meaningful about it. This does not need to be the situation, however. If the program leaders were to make an open commitment to listening to the concerns and requests of the public and then changing their programs in response to what they hear, there would be improved programs and greater public support for them. This paper addresses one such nuclear issue: involving the public effectively in decision making about the transportation of spent nuclear fuel

  1. Inner-shell physics after fifty years of quantum mechanics

    International Nuclear Information System (INIS)

    Merzbacher, E.

    1976-01-01

    A historical view is given of how the development of quantum mechanics has been affected by the information relating to inner shells, gathered by physicists since the early days of atomic physics, and of the impact of quantum mechanics on the physics of inner atomic shells. 25 refs

  2. Fifty years of nuclear fission: Nuclear data and measurements series

    International Nuclear Information System (INIS)

    Lynn, J.E.

    1989-06-01

    This report is the written version of a colloquium first presented at Argonne National Laboratory in January 1989. The paper begins with an historical preamble about the events leading to the discovery of nuclear fission. This leads naturally to an account of early results and understanding of the fission phenomena. Some of the key concepts in the development of fission theory are then discussed. The main theme of this discussion is the topography of the fission barrier, in which the interplay of the liquid-drop model and nucleon shell effects lead to a wide range of fascinating phenomena encompassing metastable isomers, intermediate-structure effects in fission cross-sections, and large changes in fission product properties. It is shown how study of these changing effects and theoretical calculations of the potential energy of the deformed nucleus have led to broad qualitative understanding of the nature of the fission process. 54 refs., 35 figs

  3. Fifty years of crop protection, 1950-2000

    NARCIS (Netherlands)

    Zadoks, J.C.

    2002-01-01

    We detected the presence of fructosamine in human and bovine semen. In seminal plasma of healthy normozoospermic men (N = 17) fructosamine was found in 53% of the cases (fru+). In fru+ semen samples the concentration of fructosamine was (mean ± S.E.M., N = 9) 0.45 ± 0.09 mmol/L and varied from 0.15

  4. Fifty years of particle physics at the CEA

    International Nuclear Information System (INIS)

    Turlay, R.

    1997-01-01

    A historical review of researches at the CEA (and more particularly at Saclay) in particle physics, is presented. Contributions in themes such as polarized targets, bubble chambers, classic and superconductive magnets, etc. resulted in cooperation to the design of various machines such as Van de Graaff accelerator, cyclotron, Saturne, etc. Collaborations between CEA and CERN had led to numerous experiments in high energy physics, such as electronic experiments with the SPS accelerator. CEA was also involved in the intermediate boson discovery on the SppS collision apparatus, and is participating in two CERN's programs, neutrino physics (NOMAD) and CP violation (NA48). CEA is also collaborating with Russian, German and American laboratories in these domains

  5. Coral seas in fifty years: Need for local policies

    Science.gov (United States)

    Longley, P.; Cheng, N. S.; Fontaine, R. M.; Horton, K.; Bhattacharya, A.

    2017-12-01

    Arising stressors from both global and local sources threaten coral reefs, with studies indicating that local and global sources might reduce coral resilience. Local sources include sediment stress and nutrient stress from fishing; global sources include increasing sea surface temperature and ocean acidification. Through an in-depth review and re-analysis of published work, conducted under the scope of a course in the spring of 2017 semester and follow up research over the summer of 2017 and fall of 2017, students in Environmental Studies Course, ENVS 4100: Coral reefs, at the University of Colorado Boulder have developed a framework to initiate a discussion of global and local policies focused on protection of coral reefs. The research aims to assess current threats and suggest mitigation efforts. The paper uses secondary research to analyze impact of ocean acidification on aragonite saturation levels, current thermal stress, nutrient stress, and sediment factors that influence the health of coral and its surrounding ecosystem over the Common Era. Case studies in this paper include the Caribbean and Red Sea coral reefs, due to the variation of the atmosphere, temperature, and human activity in these regions. This paper intends to offer sufficient evidence that will lead to appropriate policy decisions that pertain to reef conservation.

  6. Duration of post-vaccination immunity to yellow fever in volunteers eight years after a dose-response study.

    Science.gov (United States)

    de Menezes Martins, Reinaldo; Maia, Maria de Lourdes S; de Lima, Sheila Maria Barbosa; de Noronha, Tatiana Guimarães; Xavier, Janaina Reis; Camacho, Luiz Antonio Bastos; de Albuquerque, Elizabeth Maciel; Farias, Roberto Henrique Guedes; da Matta de Castro, Thalita; Homma, Akira

    2018-06-27

    In 2009, Bio-Manguinhos conducted a dose-response study with the yellow fever vaccine, administering the vaccine in the usual mean dose of 27,476 IU (full dose, reference) and in tapered doses (10,447 IU, 3013 IU, 587 IU, 158 IU, and 31 IU) by the usual subcutaneous route and usual volume (0.5 mL). Tapered doses were obtained by dilution in the manufacturer's laboratory, and the test batches presented industrial quality. Doses down to 587 IU showed similar immunogenicity to the full dose (27,476, reference), while the 158 IU and 31 IU doses displayed lower immunogenicity. Seropositivity was maintained at 10 months, except in the group that received the 31 IU dose. The current study aims to determine whether yellow fever seropositivity was maintained eight years after YF vaccination in non-revaccinated individuals. According to the current study's results, seropositivity was maintained in 85% of 318 participants and was similar across groups. The findings support the use of the yellow fever vaccine in fractional doses during outbreaks, but each fractional dose should have at least 587 IU. This study also supports the minimum dose required by WHO, 1000 IU. Clinicaltrials.gov NCT 03338231. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. Deutsches Atomforum turns fifty; 50 Jahre Deutsches Atomforum

    Energy Technology Data Exchange (ETDEWEB)

    Geisler, Maja [Deutsches Atomforum e.V., Berlin (Germany). Bereich Oeffentlichkeitsarbeit, Informationskreis KernEnergie

    2009-07-15

    Fifty years ago, the Deutsches Atomforum e. V. was founded to promote the peaceful uses of nuclear power in Germany. On July 1, 2009, the organization celebrated its fiftieth birthday in Berlin. The anniversary was celebrated in the Berlin electricity plant, Germany's oldest existing building for commercial electricity generation. DAtF President Dr. Walter Hohlefelder welcomed some 200 high-ranking guests from politics, industry, and from the nuclear community, above all, the Chancellor of the Federal Republic of Germany, Dr. Angela Merkel, and, as keynote speaker, Professor Dr. Arnulf Baring. (orig.)

  8. Fifty shades of exploitation: Fan labor and Fifty Shades of Grey

    Directory of Open Access Journals (Sweden)

    Bethan Jones

    2014-03-01

    Full Text Available This exploration of the debates that have taken place in fandom over the ethics of pulling fan fiction and publishing it as original work draws on the notion of the fannish gift economy, which postulates that gifts such as fan fiction and fan art have value in the fannish community because they are designed to create and cement its social structure. Tension exists between fans who subscribe to the notion of a fannish gift economy and those who exploit fandom by using it to sell their pulled-to-publish works. An examination of E. L. James's 2012 Fifty Shades trilogy (comprising the books Fifty Shades of Grey, Fifty Shades Darker, and Fifty Shades Freed, which began as Twilight fan fiction, in addition to Twilight fan art sold through sites such as Redbubble and Etsy, demonstrates a tension between the two modes of fan expression: sale of artworks appears to be an acceptable practice in fandom, but the commercial sale of fan fic, even when marketed as original fiction, is widely contested.

  9. Development of 1-year-old computational phantom and calculation of organ doses during CT scans using Monte Carlo simulation

    International Nuclear Information System (INIS)

    Pan, Yuxi; Qiu, Rui; Ge, Chaoyong; Xie, Wenzhang; Li, Junli; Gao, Linfeng; Zheng, Junzheng

    2014-01-01

    With the rapidly growing number of CT examinations, the consequential radiation risk has aroused more and more attention. The average dose in each organ during CT scans can only be obtained by using Monte Carlo simulation with computational phantoms. Since children tend to have higher radiation sensitivity than adults, the radiation dose of pediatric CT examinations requires special attention and needs to be assessed accurately. So far, studies on organ doses from CT exposures for pediatric patients are still limited. In this work, a 1-year-old computational phantom was constructed. The body contour was obtained from the CT images of a 1-year-old physical phantom and the internal organs were deformed from an existing Chinese reference adult phantom. To ensure the organ locations in the 1-year-old computational phantom were consistent with those of the physical phantom, the organ locations in 1-year-old computational phantom were manually adjusted one by one, and the organ masses were adjusted to the corresponding Chinese reference values. Moreover, a CT scanner model was developed using the Monte Carlo technique and the 1-year-old computational phantom was applied to estimate organ doses derived from simulated CT exposures. As a result, a database including doses to 36 organs and tissues from 47 single axial scans was built. It has been verified by calculation that doses of axial scans are close to those of helical scans; therefore, this database could be applied to helical scans as well. Organ doses were calculated using the database and compared with those obtained from the measurements made in the physical phantom for helical scans. The differences between simulation and measurement were less than 25% for all organs. The result shows that the 1-year-old phantom developed in this work can be used to calculate organ doses in CT exposures, and the dose database provides a method for the estimation of 1-year-old patient doses in a variety of CT examinations. (paper)

  10. High-Dose-Rate Monotherapy for Localized Prostate Cancer: 10-Year Results

    Energy Technology Data Exchange (ETDEWEB)

    Hauswald, Henrik; Kamrava, Mitchell R.; Fallon, Julia M.; Wang, Pin-Chieh; Park, Sang-June; Van, Thanh; Borja, Lalaine; Steinberg, Michael L.; Demanes, D. Jeffrey, E-mail: JDemanes@mednet.ucla.edu

    2016-03-15

    Purpose: High-dose-rate (HDR) brachytherapy was originally used with external beam radiation therapy (EBRT) to increase the dose to the prostate without injuring the bladder or rectum. Numerous studies have reported HDR brachytherapy is safe and effective. We adapted it for use without EBRT for cases not requiring lymph node treatment. Patients and Methods: We entered the patient demographics, disease characteristics, and treatment parameters into a prospective registry and serially added follow-up data for 448 men with low-risk (n=288) and intermediate-risk (n=160) prostate cancer treated from 1996 to 2009. Their median age was 64 years (range 42-90). The median prostate-specific antigen (PSA) level was 6.0 ng/mL (range 0.2-18.2). The Gleason score was ≤6 in 76% and 7 in 24%. The median dose was 43.5 Gy in 6 fractions. The clinical and biochemical disease control and survival rates were calculated. Adverse events were graded according to the Common Toxicity Criteria of Adverse Events. Results: The median follow-up period was 6.5 years (range 0.3-15.3). The actuarial 6- and 10-year PSA progression-free survival was 98.6% (95% confidence interval [CI] 96.9%-99.4%) and 97.8% (95% CI 95.5%-98.9%). Overall survival at 10 years was 76.7% (95% CI 69.9%-82.2%). The local control, distant metastasis-free survival, and cause-specific survival were 99.7% (95% CI 97.9%-99.9%), 98.9% (95% CI 96.3%-99.7%), and 99.1% (95% CI 95.8%-99.8%). T stage, initial PSA level, Gleason score, National Comprehensive Cancer Network risk group, patient age, and androgen deprivation therapy did not significantly correlate with disease control or survival. No late grade 3 to 4 rectal toxicities developed. Late grade 3 to 4 genitourinary toxicity occurred in 4.9% (grade 3 in 4.7%). Conclusions: HDR monotherapy is a safe and highly effective treatment of low- and intermediate-risk prostate cancer.

  11. FIFTY-FIVE GALLON DRUM STANDARD STUDY

    International Nuclear Information System (INIS)

    Puigh, R.J.

    2009-01-01

    Fifty-five gallon drums are routinely used within the U.S. for the storage and eventual disposal of fissionable materials as Transuranic or low-level waste. To support these operations, criticality safety evaluations are required. A questionnaire was developed and sent to selected Endusers at Hanford, Idaho National Laboratory, Lawrence Livermore National Laboratory, Oak Ridge and the Savannah River Site to solicit current practices. This questionnaire was used to gather information on the kinds of fissionable materials packaged into drums, the models used in performing criticality safety evaluations in support of operations involving these drums, and the limits and controls established for the handling and storage of these drums. The completed questionnaires were reviewed and clarifications solicited through individual communications with each Enduser to obtain more complete and consistent responses. All five sites have similar drum operations involving thousands to tens of thousands of fissionable material waste drums. The primary sources for these drums are legacy (prior operations) and decontamination and decommissioning wastes at all sites except Lawrence Livermore National Laboratory. The results from this survey and our review are discussed in this paper

  12. ``Fifty-fifty`` - an unexpectedly successful start. Implementation of Agenda 21 results in energy savings in school buildings; ``Fifty-fifty`` - ein erfreulich erfolgreicher Start. Energieeinsparung durch praktizierte Agenda 21 in Schulen

    Energy Technology Data Exchange (ETDEWEB)

    Schafhausen, F. [Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)

    1998-10-01

    The idea of the `Fifty-Fifty` pilot project was conceived at the environmental department of the Hamburg municipal authority; its implementation took place in close cooperation with the department for schools, the young, and vocational training (`BSJB`). It started in October 94 and was finalized in June 97. After its successful completion, `Fifty-Fifty` meanwhile has the status of a permanent project.- For decades it has been known that public buildings consume added energy (power and heat) as well as water not only because technical devices are lacking or obsolete but also because of negligence and carelessness. `Fifty-Fifty` endeavours to bring about a change. (orig.) [Deutsch] Geschichte des `Fifty-fifty`-Modells: Die Idee wurde von der Hamburger Umweltbehoerde entwickelt und in enger Zusammenarbeit mit der Behoerde fuer Schule, Jugend und Berufsbildung (BSJB) umgesetzt. Der Modellversuch wurde im Oktober 1994 gestartet und im Juni 1997 abgeschlossen. Nach der erfolgreichen Beendigung des Modellversuchs hat `Fifty-fifty` mittlerweile den Status eines Dauerprojekts. Seit Jahrzehnten ist bekannt, dass in oeffentlich genutzten Gebaeuden nicht nur aufgrund fehlender oder veralteter technischer Ausstattung, sondern insbesondere auch wegen eines unsachgemaessen oder gedankenlosen Verhaltens mehr Energie (Strom und Waerme) und mehr Wasser verbraucht werden. `Fifty-fifty` tut etwas dagegen. (orig.)

  13. Offsite radiation doses from Hanford Operations for the years 1983 through 1987: A comparison of results calculated by two methods

    International Nuclear Information System (INIS)

    Soldat, J.K.

    1989-10-01

    This report compares the results of the calculation of potential radiation doses to the public by two different environmental dosimetric systems for the years 1983 through 1987. Both systems project the environmental movement of radionuclides released with effluents from Hanford operations; their concentrations in air, water, and foods; the intake of radionuclides by ingestion and inhalation; and, finally, the potential radiation doses from radionuclides deposited in the body and from external sources. The first system, in use for the past decade at Hanford, calculates radiation doses in terms of 50-year cumulative dose equivalents to body organs and to the whole body, based on the methodology defined in ICRP Publication 2. This system uses a suite of three computer codes: PABLM, DACRIN, and KRONIC. In the new system, 50-year committed doses are calculated in accordance with the recommendations of the ICRP Publications 26 and 30, which were adopted by the US Department of Energy (DOE) in 1985. This new system calculates dose equivalent (DE) to individual organs and effective dose equivalent (EDE). The EDE is a risk-weighted DE that is designed to be an indicator of the potential health effects arising from the radiation dose. 16 refs., 1 fig., 38 tabs

  14. Three Mile Island epidemiologic radiation dose assessment revisited: 25 years after the accident.

    Science.gov (United States)

    Field, R William

    2005-01-01

    Over the past 25 years, public health concerns following the Three Mile Island (TMI) accident prompted several epidemiologic investigations in the vicinity of TMI. One of these studies is ongoing. This commentary suggests that the major source of radiation exposure to the population has been ignored as a potential confounding factor or effect modifying factor in previous and ongoing TMI epidemiologic studies that explore whether or not TMI accidental plant radiation releases caused an increase in lung cancer in the community around TMI. The commentary also documents the observation that the counties around TMI have the highest regional radon potential in the United States and concludes that radon progeny exposure should be included as part of the overall radiation dose assessment in future studies of radiation-induced lung cancer resulting from the TMI accident.

  15. Three Mile Island epidemiologic radiation dose assessment revisited: 25 years after the accident

    International Nuclear Information System (INIS)

    Field, R. W.

    2005-01-01

    Over the past 25 years, public health concerns following the Three Mile Island (TMI) accident prompted several epidemiologic investigations in the vicinity of TMI. One of these studies is ongoing. This commentary suggests that the major source of radiation exposure to the population has been ignored as a potential confounding factor or effect modifying factor in previous and ongoing TMI epidemiologic studies that explore whether or not TMI accidental plant radiation releases caused an increase in lung cancer in the community around TMI. The commentary also documents the observation that the counties around TMI have the highest regional radon potential in the United States and concludes that radon progeny exposure should be included as part of the overall radiation dose assessment in future studies of radiation-induced lung cancer resulting from the TMI accident. (authors)

  16. Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period.

    Science.gov (United States)

    Namin, Arya W; Christopher, Kara M; Eisenbeis, John F

    2017-01-01

    The study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a "classic" dosing trend that initially decreases before stabilizing, and a "fluctuating" dosing trend), and (3) determine if patients with the "classic" dosing trend differed in age or in dosing intervals from those with the "fluctuating" dosing trend. This is a retrospective case series. Of 149 patients who received a total of 2484 BTX injections for the treatment of spasmodic dysphonia in 1993-2013, 49 patients received at least 20 injections. The BTX dose and the interval between doses were recorded. The mean dose of injections 1-20 was determined. The age at initial injection, initial dose, and interval in days between treatments were compared for the "fluctuating" and "classic" groups. The cohort exhibits a significant decrease in dose during the first 10-15 injections. The "fluctuating" group had a significantly shorter interval between injections (mean interval = 97.09 days, SD = 29.41; mean interval = 136.90 days, SD = 43.76, P = 0.002). The mean age at initial dose was not significantly different between the "classic" and "fluctuating" groups. The average BTX dose of patients with ADSD who receive long-term injections significantly decreases during the initial 10-15 injections before stabilizing. Patients who exhibit the "fluctuating" dosing pattern have a significantly shorter interval between injections than those with the "classic" dosing pattern. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  17. HADOC: a computer code for calculation of external and inhalation doses from acute radionuclide releases

    International Nuclear Information System (INIS)

    Strenge, D.L.; Peloquin, R.A.

    1981-04-01

    The computer code HADOC (Hanford Acute Dose Calculations) is described and instructions for its use are presented. The code calculates external dose from air submersion and inhalation doses following acute radionuclide releases. Atmospheric dispersion is calculated using the Hanford model with options to determine maximum conditions. Building wake effects and terrain variation may also be considered. Doses are calculated using dose conversion factor supplied in a data library. Doses are reported for one and fifty year dose commitment periods for the maximum individual and the regional population (within 50 miles). The fractional contribution to dose by radionuclide and exposure mode are also printed if requested

  18. Cumulative high doses of inhaled formoterol have less systemic effects in asthmatic children 6-11 years-old than cumulative high doses of inhaled terbutaline.

    Science.gov (United States)

    Kaae, Rikke; Agertoft, Lone; Pedersen, Sören; Nordvall, S Lennart; Pedroletti, Christophe; Bengtsson, Thomas; Johannes-Hellberg, Ingegerd; Rosenborg, Johan

    2004-10-01

    To evaluate high dose tolerability and relative systemic dose potency between inhaled clinically equipotent dose increments of formoterol and terbutaline in children. Twenty boys and girls (6-11 years-old) with asthma and normal ECGs were studied. Ten doses of formoterol (Oxis) 4.5 microg (F4.5) or terbutaline (Bricanyl) 500 microg (T500) were inhaled cumulatively via a dry powder inhaler (Turbuhaler) over 1 h (three patients) or 2.5 h (17 patients) and compared to a day of no treatment, in a randomised, double-blind (active treatments only), crossover trial. Blood pressure (BP), ECG, plasma potassium, glucose, lactate, and adverse events were monitored up to 10 h to assess tolerability and relative systemic dose potency. Formoterol and terbutaline had significant beta2-adrenergic effects on most outcomes. Apart from the effect on systolic BP, QRS duration and PR interval, the systemic effects were significantly more pronounced with terbutaline than with formoterol. Thus, mean minimum plasma potassium, was suppressed from 3.56 (95% confidence interval, CI: 3.48-3.65) mmol l(-1) on the day of no treatment to 2.98 (CI: 2.90-3.08) after 10 x F4.5 and 2.70 (CI: 2.61-2.78) mmol l(-1) after 10 x T500, and maximum Q-Tc (heart rate corrected Q-T interval [Bazett's formula]) was prolonged from 429 (CI: 422-435) ms on the day of no treatment, to 455 (CI: 448-462) ms after 10 x F4.5 and 470 (CI: 463-476) ms after 10 x T500. Estimates of relative dose potency indicated that F4.5 microg had the same systemic activity as the clinically less effective dose of 250 microg terbutaline. The duration of systemic effects differed marginally between treatments. Spontaneously reported adverse events (most frequently tremor) were fewer with formoterol (78% of the children) than with terbutaline (95%). A serious adverse event occurred after inhalation of 45 microg formoterol over the 1 h dosing time, that prompted the extension of dosing time to 2.5 h. Multiple inhalations over 2.5 h of

  19. Cumulative high doses of inhaled formoterol have less systemic effects in asthmatic children 6–11 years-old than cumulative high doses of inhaled terbutaline

    Science.gov (United States)

    Kaae, Rikke; Agertoft, Lone; Pedersen, Sören; Nordvall, S Lennart; Pedroletti, Christophe; Bengtsson, Thomas; Johannes-Hellberg, Ingegerd; Rosenborg, Johan

    2004-01-01

    Objectives To evaluate high dose tolerability and relative systemic dose potency between inhaled clinically equipotent dose increments of formoterol and terbutaline in children. Methods Twenty boys and girls (6–11 years-old) with asthma and normal ECGs were studied. Ten doses of formoterol (Oxis®) 4.5 µg (F4.5) or terbutaline (Bricanyl®) 500 µg (T500) were inhaled cumulatively via a dry powder inhaler (Turbuhaler®) over 1 h (three patients) or 2.5 h (17 patients) and compared to a day of no treatment, in a randomised, double-blind (active treatments only), crossover trial. Blood pressure (BP), ECG, plasma potassium, glucose, lactate, and adverse events were monitored up to 10 h to assess tolerability and relative systemic dose potency. Results Formoterol and terbutaline had significant β2-adrenergic effects on most outcomes. Apart from the effect on systolic BP, QRS duration and PR interval, the systemic effects were significantly more pronounced with terbutaline than with formoterol. Thus, mean minimum plasma potassium, was suppressed from 3.56 (95% confidence interval, CI: 3.48–3.65) mmol l−1 on the day of no treatment to 2.98 (CI: 2.90–3.08) after 10 × F4.5 and 2.70 (CI: 2.61–2.78) mmol l−1 after 10 × T500, and maximum Q-Tc (heart rate corrected Q-T interval [Bazett's formula]) was prolonged from 429 (CI: 422–435) ms on the day of no treatment, to 455 (CI: 448–462) ms after 10 × F4.5 and 470 (CI: 463–476) ms after 10 × T500. Estimates of relative dose potency indicated that F4.5 µg had the same systemic activity as the clinically less effective dose of 250 µg terbutaline. The duration of systemic effects differed marginally between treatments. Spontaneously reported adverse events (most frequently tremor) were fewer with formoterol (78% of the children) than with terbutaline (95%). A serious adverse event occurred after inhalation of 45 µg formoterol over the 1 h dosing time, that prompted the extension of dosing time to 2.5 h

  20. Tennessee Valley region study: potential year 2000 radiological dose to population resulting from nuclear facility operations. [Includes glossary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    A companion report, DOE/ET-0064/1, presents a geographic, cultural, and demographic profile of the Tennessee Valley Region study area. This report describes the calculations of radionuclide release and transport and of the resultant dose to the regional population, assuming a projected installed capacity of 220,000 MW in the year 2000, of which 144,000 MW would be nuclear. All elements of the fuel cycle were assumed to be in operation. The radiological dose was calculated as a one-year dose based on ingestion of 35 different food types as well as for nine non-food pathways, and was reported as dose to the total body and for six specific organs for each of four age groups (infant, child, teen, and adult). Results indicate that the average individual would receive an incremental dose of 7 x 10/sup -4/ millirems in the year 2000 from the operation of nuclear facilities within and adjacent to the region, five orders of magnitude smaller than the dose from naturally occurring radiation in the area. The major contributor to dose was found to be tritium, and the most significant pathways were immersion in air, inhalation of air, transpiration of tritium (absorption through the skin), and exposure radionuclide-containing soil. 60 references.

  1. Long-term Dose Stability of OnabotulinumtoxinA Injection for Adductor Spasmodic Dysphonia: A 19-Year Single Institution Experience

    Directory of Open Access Journals (Sweden)

    Paul Paddle

    2017-11-01

    Full Text Available ObjectivesAdductor spasmodic dysphonia (AdSD is a focal dystonia predominantly involving the laryngeal adductor muscles. AdSD is reported to be a largely non-progressive neurological disorder, though fluctuations in symptom severity do occur. Repeated laryngeal onabotulinumtoxinA (BTX-A injections are the primary management for AdSD. A number of studies have demonstrated long-term dose stability as evidence of this long-term disease stability.MethodsA retrospective review was performed on all patients undergoing BTX-A injections for AdSD from April 1994 to September 2013 by a single laryngologist at a tertiary referral laryngology center. Patient demographics, injection doses, use of diazepam and/or lidocaine, and self-reported vocal function were recorded. Multiple linear regression analyses were performed.Results83 patients underwent a total of 1,168 injections over 19 years. The mean starting dose was 2.35 MU (0.79 SD. The mean long-term dose was 2.36 MU (0.79 SD. After adjusting for confounders, the change in the relative dose of BTX-A, with every year elapsed since initial dose was 0.13% (95% confidence interval −0.31 to 0.57%, p = 0.568.ConclusionBTX-A dose is stable over time in our large cohort of patients treated with bilateral thyroarytenoid injections for AdSD.

  2. Mathematical card magic fifty-two new effects

    CERN Document Server

    Mulcahy, Colm

    2013-01-01

    Mathematical card effects offer both beginning and experienced magicians an opportunity to entertain with a minimum of props. Featuring mostly original creations, Mathematical Card Magic: Fifty-Two New Effects presents an entertaining look at new mathematically based card tricks. Each chapter contains four card effects, generally starting with simple applications of a particular mathematical principle and ending with more complex ones. Practice a handful of the introductory effects and, in no time, you'll establish your reputation as a "mathemagician." Delve a little deeper into each chapter and the mathematics gets more interesting. The author explains the mathematics as needed in an easy-to-follow way. He also provides additional details, background, and suggestions for further explorations.Suitable for recreational math buffs and amateur card lovers or as a text in a first-year seminar, this color book offers a diverse collection of new mathemagic principles and effects.

  3. Diabetes mellitus during pregnancy: a study of fifty cases

    International Nuclear Information System (INIS)

    Randhawa, M. S.; Moin, S.; Shoaib, F.

    2003-01-01

    To review and critically evaluated the incidence, epidemiology, clinical pattern, diagnosis, management, complications and outcome of diabetes mellitus during pregnancy in hospital based study. Results: Total number of women delivered were 11271. Fifty cases of diabetes mellitus during pregnancy were studied. Mostly the patients were more than 30 years of age, multiparous ladies with gestational diabetes in 80% of cases, Type-II diabetes in 16% and only in 4% Type-I diabetes was reported. Insulin was required in 40% of patients. Eight women out of 50 had spontaneous miscarriage, 5 underwent preterm delivery while 36 reached term with one intrauterine death. Total number of babies delivered alive were 41. There was one stillbirth and 3 neonatal deaths. Conclusion: Management of diabetes mellitus in pregnancy involves teamwork of obstetricians, physicians and neonatologists. (author)

  4. Chevy Corvette: Icon Of American Life In The Fifties

    Directory of Open Access Journals (Sweden)

    Wishnoebroto Wishnoebroto

    2007-11-01

    Full Text Available Cars not only function simply as a mean of transportation. Like paintings, the design of a car could represent a certain cultural and social phenomenon of a country. The design of Chevrolet (Chevy Corvette is very different compared to its competitors in the 50s. The size, engine, weight, and the materials of this car were chosen based on the assumption that speed and agility is on top of everything. It was not surprising that in the 50s, the year when the first Corvette was designed and launched, The US was involved in a cold war with the Soviets. Arm race and competition to be the first was the major issue and Corvette was the first car that suggests this spirit. This paper tries to show the distinctiveness of Corvette and how it can be used to explain the character of American people in the fifties

  5. Development and use of a fifteen year-old equivalent mathematical phantom for internal dose calculations. [Radiation dose distributions from /sup 99m/Tc-labeled compounds

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R.M.; Poston, J.W.; Hwang, J.L.; Jones, T.D.; Warner, G.G.

    1976-06-01

    The existence of a phantom based on anatomical data for the average fifteen-year-old provides for a proficient means of obtaining estimates of absorbed dose for children of that age. Dimensions representative of an average fifteen-year-old human, obtained from various biological and medical research, were transformed into a mathematical construct of idealized shapes of the exterior, skeletal system, and internal organs of a human. The idealization for an average adult presently in use by the International Commission on Radiological Protection was used as a basis for design. The mathematical equations describing the phantom were developed to be readily adaptable to present-day methods of dose estimation. Typical exposure situations in nuclear medicine have previously been modeled for existing phantoms. With no further development of the exposure model necessary, adaptation to the fifteen-year-old phantom demonstrated the utility of the design. Estimates of absorbed dose were obtained for the administration of two radiopharmaceuticals, /sup 99m/Tc-sulfur colloid and /sup 99m/Tc-DMSA. (auth)

  6. Nuclear histochemistry: Its history in fifty volumes

    Directory of Open Access Journals (Sweden)

    M.G. Manfredi Romanini

    2014-01-01

    Full Text Available The fiftieth anniversary of the double helix was marked two years ago. The elucidation of the structure of DNA by Watson and Crick can rightfully be considered to be "the" milestone in modern biology because it has conditioned the explosive growth in our understanding of the molecular mechanisms regulating the structural and functional organization of single cells and multicellular organisms....

  7. Inverse Planned High-Dose-Rate Brachytherapy for Locoregionally Advanced Cervical Cancer: 4-Year Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Tinkle, Christopher L.; Weinberg, Vivian [Department of Radiation Oncology, University of California, San Francisco, California (United States); Chen, Lee-May [Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California (United States); Littell, Ramey [Gynecologic Oncology, The Permanente Medical Group, San Francisco, California (United States); Cunha, J. Adam M.; Sethi, Rajni A. [Department of Radiation Oncology, University of California, San Francisco, California (United States); Chan, John K. [Gynecologic Oncology, California Pacific Medical Center, San Francisco, California (United States); Hsu, I-Chow, E-mail: ichow.hsu@ucsf.edu [Department of Radiation Oncology, University of California, San Francisco, California (United States)

    2015-08-01

    Purpose: Evaluate the efficacy and toxicity of image guided brachytherapy using inverse planning simulated annealing (IPSA) high-dose-rate brachytherapy (HDRB) boost for locoregionally advanced cervical cancer. Methods and Materials: From December 2003 through September 2009, 111 patients with primary cervical cancer were treated definitively with IPSA-planned HDRB boost (28 Gy in 4 fractions) after external radiation at our institution. We performed a retrospective review of our experience using image guided brachytherapy. Of the patients, 70% had a tumor size >4 cm, 38% had regional nodal disease, and 15% had clinically evident distant metastasis, including nonregional nodal disease, at the time of diagnosis. Surgical staging involving pelvic lymph node dissection was performed in 15% of patients, and 93% received concurrent cisplatin-based chemotherapy. Toxicities are reported according to the Common Terminology Criteria for Adverse Events version 4.0 guidelines. Results: With a median follow-up time of 42 months (range, 3-84 months), no acute or late toxicities of grade 4 or higher were observed, and grade 3 toxicities (both acute and late) developed in 8 patients (1 constitutional, 1 hematologic, 2 genitourinary, 4 gastrointestinal). The 4-year Kaplan-Meier estimate of late grade 3 toxicity was 8%. Local recurrence developed in 5 patients (4 to 9 months after HDRB), regional recurrence in 3 (6, 16, and 72 months after HDRB), and locoregional recurrence in 1 (4 months after HDR boost). The 4-year estimates of local, locoregional, and distant control of disease were 94.0%, 91.9%, and 69.1%, respectively. The overall and disease-free survival rates at 4 years were 64.3% (95% confidence interval [CI] of 54%-73%) and 61.0% (95% CI, 51%-70%), respectively. Conclusions: Definitive radiation by use of inverse planned HDRB boost for locoregionally advanced cervical cancer is well tolerated and achieves excellent local control of disease. However, overall

  8. On the radiation exposure dose and health management history during 50 years of x-ray working

    International Nuclear Information System (INIS)

    Yoshida, Tomihiro

    1981-01-01

    My X-ray working history has become 50 years at the end of April, 1980. At this chance, the following data were summarized; the case numbers of X-ray photographs (517,132 cases), total amounts of radiation exposure dose (66.85 roentgen) and the results of blood test, which were experienced during past 50 years. The amounts of exposure dose during 35 years till 1965 were measured using my own method, which measured the film blackening as 30 milli-roentgen per week by certain standard method. After 1966 till 1980, the exposure dose were recorded using that of the film-badge service of Nippon Hoan Yohin Kyokai. The total amounts of exposure dose during 50 years were about 1/4 of D = 5 (N - 18). The results of blood test during last 27 years were found to be normal values. Then, it is happy to say that my body has been protected completely, from radiation hazard as a result of taking radiation protection and checking blood test always at my daily radiation works. The data of my own experiences during 50 years are summarized and reported in this paper. (author)

  9. Lloyd Berkner: Catalyst for Meteorology's Fabulous Fifties

    Science.gov (United States)

    Lewis, J. M.

    2002-05-01

    In the long sweep of meteorological history - from Aristotle's Meteorologica to the threshold of the third millennium - the 1950s will surely be recognized as a defining decade. The contributions of many individuals were responsible for the combination of vision and institution building that marked this decade and set the stage for explosive development during the subsequent forty years. In the minds of many individuals who were active during those early years, however, one name stands out as a prime mover par excellence: Lloyd Viel Berkner. On May 1, 1957, Berkner addressed the National Press Club. The address was entitled, "Horizons of Meteorology". It reveals Berkner's insights into meteorology from his position as Chairman of the Committee on Meteorology of the National Academy of Sciences, soon to release the path-breaking report, Research and Education in Meteorology (1958). The address also reflects the viewpoint of an individual deeply involved in the International Geophysical Year (IGY). It is an important footnote to meteorological history. We welcome this opportunity to profile Berkner and to discuss "Horizons of Meteorology" in light of meteorology's state-of-affairs in the 1950s and the possible relevance to Berkner's ideas to contemporary issues.

  10. Yearly stepwise increments of the growth hormone dose results in a better growth response after four years in girls with Turner syndrome. Dutch Working Group on Growth Hormone

    NARCIS (Netherlands)

    van Teunenbroek, A.; de Muinck Keizer-Schrama, S. M.; Stijnen, T.; Jansen, M.; Otten, B. J.; Delemarre-van de Waal, H. A.; Vulsma, T.; Wit, J. M.; Rouwé, C. W.; Reeser, H. M.; Gosen, J. J.; Rongen-Westerlaken, C.; Drop, S. L.

    1996-01-01

    To optimize the growth promoting effect of growth hormone (GH), 65 previously untreated girls with Turner syndrome (TS), chronological age (CA) 2-11 yr, were randomized into 3 dosage regimen groups: A, B, and C, with a daily recombinant-human GH dose during 4 study years of 4-4-4-4, 4-6-6-6, and

  11. One year follow-up reveals no difference in quality of life between high dose and conventional dose radiation: a quality of life assessment of RTOG 94-05

    International Nuclear Information System (INIS)

    Kachnic, L.A.; Scott, C.; Ginsberg, R.; Pisansky, T.; Martenson, J.; Komaki, R.; Okawara, G.; Rosenthal, S.; Kelsen, D.; Minsky, B.

    2001-01-01

    histology did not significantly correlate with overall pre-treatment QOL. At treatment completion, 96 patients (46%) completed QOL forms (46 HD, 50 CD); non-participation was due to death in 17, delayed completion in 23 and missing in 33. QOL was worse post-treatment in both arms with total QOL scores significantly lower than baseline in the HD arm (p=0.05). Similarly, women reported lower QOL on the 64.8 Gy arm (overall QOL p=0.06, physical well-being p=0.06, relationship with physician p=0.02 and emotional well-being p=0.02). Among the various QOL domains, pre-treatment weight loss of ≥10% only significantly correlated with decreased family well-being on the HD arm (p=0.04). Seventy-three patients (35%) participated in QOL assessment at 8 months post CMT (40 HD, 33 CD); the principle reason for non-participation was patient death. QOL scores were similarly restored to baseline in the two treatment arms, with head and neck symptoms reported as improved. Pre-treatment weight loss remained a significant predictor for overall QOL, as well as for social and family well being. Gender had no significant effect on QOL at 8 months. Fifty-seven patients were available for QOL participation at 1 year (25 HD, 32 CD) with no significant differences in QOL scores between the two treatment arms. Preliminary analysis at 2 years showed no local control or survival benefit for the high dose arm. Conclusion: In this randomized trial of RT dose escalation, functional and symptomatic scores of QOL were decreased after CMT in both treatment arms with total QOL scores significantly poorer than baseline in the high dose group. This early decrease in QOL for the 64.8 Gy arm was restored to baseline after 8 months, and at 1 year there were no significant differences in QOL scores between the two treatment arms. Therefore, for patients treated with CMT for esophageal cancer who remain alive at 1 year, RT dose escalation to 64.8 Gy appears to be as well tolerated as the conventional 50.4 Gy arm

  12. Use of high-dose, twice-yearly albendazole and ivermectin to suppress Wuchereria bancrofti microfilarial levels.

    Science.gov (United States)

    Dembele, Benoit; Coulibaly, Yaya I; Dolo, Housseini; Konate, Siaka; Coulibaly, Siaka Y; Sanogo, Dramane; Soumaoro, Lamine; Coulibaly, Michel E; Doumbia, Salif Seriba; Diallo, Abdallah A; Traore, Sekou F; Diaman Keita, Adama; Fay, Michael P; Nutman, Thomas B; Klion, Amy D

    2010-12-01

    Annual mass treatment with albendazole and ivermectin is the mainstay of current strategies to interrupt transmission of Wuchereria bancrofti in Africa. More-effective microfilarial suppression could potentially reduce the time necessary to interrupt transmission, easing the economic burden of mass treatment programs in countries with limited resources. To determine the effect of increased dose and frequency of albendazole-ivermectin treatment on microfilarial clearance, 51 W. bancrofti microfilaremic residents of an area of W. bancrofti endemicity in Mali were randomized to receive 2 doses of annual, standard-dose albendazole-ivermectin therapy (400 mg and 150 μg/kg; n = 26) or 4 doses of twice-yearly, increased-dose albendazole-ivermectin therapy (800 mg and 400 μg/kg; n = 25). Although microfilarial levels decreased significantly after therapy in both groups, levels were significantly lower in the high-dose, twice-yearly group at 12, 18, and 24 months. Furthermore, there was complete clearance of detectable microfilariae at 12 months in the 19 patients in the twice-yearly therapy group with data available at 12 months, compared with 9 of 21 patients in the annual therapy group (P < .001, by Fisher's exact test). This difference between the 2 groups was sustained at 18 and 24 months, with no detectable microfilariae in the patients receiving twice-yearly treatment. Worm nests detectable by ultrasonography and W. bancrofti circulating antigen levels, as measured by enzyme-linked immunosorbent assay, were decreased to the same degree in both groups at 24 months, compared with baseline. These findings suggest that increasing the dosage and frequency of albendazole-ivermectin treatment enhances suppression of microfilariae but that this effect may not be attributable to improved adulticidal activity.

  13. Trabeculectomy with double low dose of mitomycin C – two years of follow-up

    Directory of Open Access Journals (Sweden)

    Errico D

    2011-12-01

    Full Text Available Donato Errico1, Francesca Scrimieri1, Roberta Riccardi1, Romolo Fedeli1, Giancarlo Iarossi21Opthalmology Unit, Glaucoma Service, Azienda Ospedaliera, Cardinale G Panìco, Tricase (Le, Italy; 2Department of Opthalmology, Ospedale Pediatrico Bambino Gesù, Rome, ItalyPurpose: To evaluate the efficacy and the safety of a surgical technique in which classic trabeculectomy ab externo is performed with a double application of low-dose mitomycin C (MMC in uncontrolled open-angle glaucoma (OAG patients.Method: A consecutive series of 43 white patients (43 eyes with uncontrolled primary OAG underwent trabeculectomy surgery. A double application of MMC (0.1% was performed: the first under the Tenon's capsule for 3 minutes, and the second below the scleral flap for 1 or 2 minutes, according to the risk factors. Complete success was defined as intraocular pressure (IOP <14 mmHg without any additional glaucoma surgery or medication. Qualified success was defined as IOP <14 mmHg with additional needling revision.Results: Mean preoperative IOP was 29.9 mmHg (SD 3.8 for all eyes evaluated. At 1 day postoperative, mean IOP was 6.7 mmHg (SD 1.26. At the end of the first 2 weeks postoperative, mean IOP was 8.6 mmHg (SD 1.7, at 12 months mean IOP was 11.3 mmHg (SD 1.4; P < 0.0001 and at 24 months mean IOP was 11.4 mmHg (SD 1.5; P < 0.0001. At 3 months, two eyes (5.4% underwent needling of the bleb for cystic blebs formation.Conclusion: In this study we presented the results after 2 years of follow-up of OAG undergoing trabeculectomy with dual administration of MMC (0.1 mg/mL. After 24 months, complete success was achieved in 93% of patients and a qualified success in 100% of patients.Keywords: glaucoma, trabeculectomy, mitomycin C

  14. One year of a thermoluminescent dosemeter and dose record keeping service

    International Nuclear Information System (INIS)

    Dennis, J.A.

    1979-01-01

    A brief description is given of the National Radiological Protection Board's (NRPB) thermoluminescent dosemeter. The automated processing of these dosemeters is linked to a computer-based system of dose records. The postal system is currently used by about 10% of the establishments for which the NRPB provides a personnel monitoring service, but it will soon be extended to other establishments. The distributions of individual whole body doses in 1977 are tabulated. The significant advantage of this new system lies in the improvements in accuracy, completeness, and convenience to the employers of record keeping. (U.K.)

  15. Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models

    Science.gov (United States)

    Xie, Tianwu; Kuster, Niels; Zaidi, Habib

    2017-08-01

    Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms while the argument for individualized patient-specific radiation dosimetry exists. This study aims to evaluate the influence of body habitus on internal dosimetry and to quantify the uncertainties in dose estimation correlated with the use of fixed reference models. The 5-year-old IT’IS male phantom was modified to match target anthropometric parameters, including body weight, body height and sitting height/stature ratio (SSR), determined from reference databases, thus enabling the creation of 125 5-year-old habitus-dependent male phantoms with 10th, 25th, 50th, 75th and 90th percentile body morphometries. We evaluated the absorbed fractions and the mean absorbed dose to the target region per unit cumulative activity in the source region (S-values) of F-18 in 46 source regions for the generated 125 anthropomorphic 5-year-old hybrid male phantoms using the Monte Carlo N-Particle eXtended general purpose Monte Carlo transport code and calculated the absorbed dose and effective dose of five 18F-labelled radiotracers for children of various habitus. For most organs, the S-value of F-18 presents stronger statistical correlations with body weight, standing height and sitting height than BMI and SSR. The self-absorbed fraction and self-absorbed S-values of F-18 and the absorbed dose and effective dose of 18F-labelled radiotracers present with the strongest statistical correlations with body weight. For 18F-Amino acids, 18F-Brain receptor substances, 18F-FDG, 18F-L-DOPA and 18F-FBPA, the mean absolute effective dose differences between phantoms of different habitus and fixed reference models are 11.4%, 11.3%, 10.8%, 13.3% and 11.4%, respectively. Total body

  16. Results of dose control and measurement plans applied for SPEAR3 commissioning year (FY04)

    Energy Technology Data Exchange (ETDEWEB)

    Khater, Hesham [Radiation Protection Department, Stanford Linear Accelerator Center (SLAC), 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)]. E-mail: khater1@llnl.gov; Liu, James [Radiation Protection Department, Stanford Linear Accelerator Center (SLAC), 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Prinz, Alyssa [Radiation Protection Department, Stanford Linear Accelerator Center (SLAC), 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Allan, Jim [Radiation Protection Department, Stanford Linear Accelerator Center (SLAC), 2575 Sand Hill Road, Menlo Park, CA 94025 (United States); Rokni, Sayed [Radiation Protection Department, Stanford Linear Accelerator Center (SLAC), 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)

    2006-12-15

    Dose control and measurement plans for the SPEAR3 Booster and storage ring have taken place during the SPEAR3 commissioning. The initial commissioning period (SPEAR3 start-up) covered the time period from the beginning of November 2003 to the early part of March 2004. The period from the beginning of March to the beginning of August 2004 has been mostly dedicated to the scientific program. The initial commissioning period was characterized with frequent injection and significantly higher losses. In comparison, the scientific program period was characterized with more stable beam operation with limited number of injections per day and lower beam losses. Three types of dose measurements, passive, active and special measurements, were implemented around the SPEAR3 Booster and storage ring. Based on the expected radiation hazards, several dose control measures were adopted at several stages of the commissioning. In the early stages of commissioning, areas within 4.5 m from the walls of the Booster and storage ring were designated as radiation areas (RA). Areas outside RA were classified as radiologically controlled area (RCA). Access to these areas required less training than the RA. A monthly review of the accelerator operation conditions and radiation measurement results were used to determine the changes needed for the RA classification status and associated dose control measures.

  17. Spasmodic dysphonia: a seven-year audit of dose titration and demographics in the Indian population.

    Science.gov (United States)

    Nerurkar, N K; Banu, T P

    2014-07-01

    This study aimed to evaluate the demographics of spasmodic dysphonia in the Indian population and to analyse the optimum dose titration of botulinum toxin type A in this group. A comparative analysis with international studies was also performed. The study involved a retrospective analysis and audit of botulinum toxin type A dose titration in spasmodic dysphonia patients who visited our voice clinic between January 2005 and January 2012. The average total therapeutic dose required for patients with adductor spasmodic dysphonia was 4.2 U per patient per vocal fold (total 8.4 U per patient), and for patients with abductor spasmodic dysphonia, it was 4.6 U per patient. Our audit revealed that 80 per cent of the spasmodic dysphonia patients were male, which contrasts dramatically with international studies, wherein around 80 per cent of spasmodic dysphonia patients were female. Our study also revealed a higher dose titration of botulinum toxin for the Indian spasmodic dysphonia population in both adductor and abductor spasmodic dysphonia cases.

  18. Evaluation of dose-volume histograms after prostate seed implantation. 4-year experience

    International Nuclear Information System (INIS)

    Hoinkis, C.; Lehmann, D.; Winkler, C.; Herrmann, T.; Hakenberg, O.W.; Wirth, M.P.

    2004-01-01

    Background and purpose: permanent interstitial brachytherapy by seed implantation is a treatment alternative for low-volume low-risk prostate cancer and a complex interdisciplinary treatment with a learning curve. Dose-volume histograms are used to assess postimplant quality. The authors evaluated their learning curve based on dose-volume histograms and analyzed factors influencing implantation quality. Patients and methods: since 1999, 38 patients with a minimum follow-up of 6 months were treated at the authors' institution with seed implantation using palladium-103 or iodine-125, initially using the preplan method and later real-time planning. Postimplant CT was performed after 4 weeks. The dose-volume indices D90, V100, V150, the D max of pre- and postplans, and the size and position of the volume receiving the prescribed dose (high-dose volume) of the postplans were evaluated. In six patients, postplan imaging both by CT and MRI was used and prostate volumes were compared with preimplant transrectal ultrasound volumes. The first five patients were treated under external supervision. Results: patients were divided into three consecutive groups for analysis of the learning curve (group 1: n = 5 patients treated under external supervision; group 2: n = 13 patients; group 3: n = 20 patients). D90 post for the three groups were 79.3%, 74.2%, and 99.9%, the V100 post were 78.6%, 73.5%, and 88.2%, respectively. The relationship between high-dose volume and prostate volume showed a similar increase as the D90, while the relationship between high-dose volume lying outside the prostate and prostate volume remained constant. The ratio between prostate volumes from transrectal ultrasound and CT imaging decreased with increasing D90 post , while the preplanning D90 and V100 remained constant. The different isotopes used, the method of planning, and the implanted activity per prostate volume did not influence results. Conclusion: a learning curve characterized by an increase

  19. Shift in imaging modalities of the spine through 25 years and its impact on patient ionizing radiation doses

    Energy Technology Data Exchange (ETDEWEB)

    Borgen, Lars [Department of Radiology, Hospital of Buskerud, Dronning gaten 28, 3004 Drammen (Norway)]. E-mail: lars.borgen@sb-hf.no; Ostensen, Harald [Diagnostic Imaging and Laboratory Technology, World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27 (Switzerland); Stranden, Erling [Buskerud University College, Konggate 51, 3019 Drammen (Norway); Olerud, Hilde Marie [Norwegian Radiation Protection Authority, PO Box 55, 1332 Osteras (Norway); Gudmundsen, Tor Erik [Department of Radiology, Hospital of Buskerud, Dronning gaten 28, 3004 Drammen (Norway); Buskerud University College, Konggate 51, 3019 Drammen (Norway)

    2006-10-15

    Study design: Retrospective. Objective: To explore the shift in modalities when diagnosing the spine in the years 1979-2003. To see how this shift, together with a radiation protective policy, have influenced on the ionizing radiation doses. Summary of background data: The shift from CT/myelography to MR when diagnosing the spine is well known. To what extent this has changed the radiation doses has to our knowledge not yet been published. Methods: Activity reports from a department of radiology have been reviewed. Relevant radiation doses estimates have been obtained from the Norwegian Radiation Protection Authority. Results: MRI was introduced in 1992 and has been used increasingly since then. Conventional X-ray to the spine has been practically unchanged. Myelography and CT decreased markedly after the introduction of MRI. The total number of examinations of the spine has increased, but the radiation doses given have decreased since 1993. Conclusions: The introduction of MRI together with a radiation protective policy have reduced the ionizing radiation doses given to this population, in spite of an increase in the total number of examinations of the spine.

  20. Gamma knife radio-surgery in meningiomas: decisive variables in the dose prescription during 14 years

    International Nuclear Information System (INIS)

    Dominguez O, X.; Diaz A, P.; Toledo B, V.; Zazueta L, F.

    2010-09-01

    A comparative study is presented among the variables of dose prescription in twelve cases of treated meningiomas from 1997 to 2009 in the Gamma Knife Unit of the Hospital San Javier. An evolution is observed in the definition of the treatment volumes, collimators election and matrix of dose calculation, this evolution has been due so much to the technological advance associated to the image acquisition systems: Computerized axial tomography, Images by magnetic resonance and Angiography by digital subtraction, as well as to the indexes adoption that are used to qualify among different treatment plans. The differences among the analyzed periods demonstrate a favorable learning curve that have influenced contributing to a treatment with a minor irradiated volume due to the application of theoretical models used in this installation, attenuating the risk of peripheral unexpected complications to the treated volume. (Author)

  1. High dose, fast delivery magnesium sulphate in a 3-year-old acute severe asthmatic

    Directory of Open Access Journals (Sweden)

    John R Elton

    2017-09-01

    Full Text Available Acute severe asthma when respiratory failure is imminent is not addressed in world asthma guidelines. Intravenous magnesium sulphate, salbutamol and aminophylline all have advocates but what order, speed of delivery or dosage is left up to the individual physician treating the patient. A child in respiratory failure was given a large, fast dose of intravenous magnesium sulphate before intravenous salbutamol which relaxed bronchial smooth muscle immediately and tracheal intubation and lung ventilation was avoided. Justification for this treatment is discussed.

  2. Influence of the number of daily pills and doses on adherence to antiretroviral treatment: a 7-year study.

    Science.gov (United States)

    Hernández Arroyo, M J; Cabrera Figueroa, S E; Sepúlveda Correa, R; Valverde Merino, M P; Luna Rodrigo, G; Domínguez-Gil Hurlé, A

    2016-02-01

    Antiretroviral treatment (ART) is hampered by complicated regimens, high pill burden, drug-drug interactions, and frequent short- and long-term adverse effects, leading to decreased adherence. Over recent years, considerable effort has been directed at developing regimens that are less burdening. We undertook a 7-year retrospective study of the records of 264 HIV-infected subjects enrolled in a pharmaceutical care programme to document the progress made and to study the influence of the number of ART pills and doses on the level of treatment adherence. Antiretroviral dispensing records were analysed for the number of pills and doses administered and the ART adherence rate estimated. In 2005, the patients took a mean of 6·2 pills daily (CI 95%: 5·9-6·6), and 92·9% of them were on a twice-a-day (BID) dosage regimen. By 2012, the mean number of pills was reduced to 4·1 (CI 95%: 3·8-4·4), and only 50·9% were on a BID regimen. No statistically significant relation was observed between number of daily pills and doses and ART adherence reached by the patients in any of the analyses performed. There has been a continuous reduction in the number of pills and doses of antiretrovirals taken by individual patients over the last 7 years due largely to the introduction of improved treatments and regimens. More daily pills or doses was not associated with worse ART adherence in our pharmaceutical care programme. © 2015 John Wiley & Sons Ltd.

  3. Influence of fractionation of dose on 3 year results of X-ray therapy of skin cancer

    International Nuclear Information System (INIS)

    Szymczyk, W.; Radziszewska, J.; Cyplik, I.; Glinska, H.

    1985-01-01

    Three-year results of X-ray therapy of skin cancer in 345 patients are presented. The dependence of results on the size of irradiated field and the method of dose fractionation is analysed. The clinical usefulness of a cumulative radiation effect (CRE) is evaluated. 96.5% of three-year cures were obtained. Recurrences amounted to 1.6% and necroses to 1.9% of treated lesions. It has been shown that treatment of small fields with 8-fractions gave equally positive results as with 15-fractions whereas in the treatment of large lesions the selection of CRE value, a number of fractions and dose should let the value of CRE minimally exceeds the level of tolerance of healthy tissues. The regard to CRE value in the treatment of large lesions or the introduction of additional dosimetric acts seems to be useful. 10 refs., 1 fig., 5 tabs. (author)

  4. Las notas al pie en la traducción de Fifty Shades (Footnotes in the Translation of Fifty Shades

    Directory of Open Access Journals (Sweden)

    Xinia Valverde Jara

    2017-11-01

    Full Text Available Se analiza el recurso de las notas a pie de página insertas en la traducción independiente de literatura comercial en versión digital, de la trilogía Fifty Shades of Grey, Fifty Shades Darker y Fifty Shades Freed, de E. L. James. Se examina el grado de influencia de esos elementos extratextuales, y se concluye que todos ellos, organizados en un complejo proceso de traducción, en especial los del contexto de llegada, condicionan la estrategia traductológica. Abstract This study examines the use of footnotes as a translation strategy in the independent translation of commercial literature in digital format, based on the trilogy written by E. L. James, Fifty Shades of Grey, Fifty Shades Darker and Fifty Shades Freed. The analysis measures the influence of these extratextual elements within the complex translation process, specifically those of the target language context, and it is concluded that they condition the translation strategies used.

  5. A dynamic compensation method for natural ambient dose rate based on 6 years data from the Dutch radioactivity monitoring network

    International Nuclear Information System (INIS)

    Smetsers, R.C.G.M.; Blaauboer, R.O.

    1997-01-01

    The significant variations in time exhibited by background radiation hinders a sensitive recognition of human-induced factors. A comprehensive study in the Netherlands has examined the influence of the various natural processes on the natural background using six years data from the Dutch nuclear emergency network. Results presented concentrate on temporal variations in ambient dose-equivalent rate, H*(10), and have led to simple expressions to model the ambient dose rate using a limited set of readily available parameters, i.e. air pressure, deposition rate and equilibrium equivalent decay product concentration of 222 Rn, EEDC. Best values and uncertainty ranges of the applied parameters are reported. Remaining variations, e.g. due to variations in the cosmic radiation intensity and the radon soil profile, are shown to be small in the Netherlands, with one exception when the cosmogenic dose rate at sea level was decreased for a period of months due to a global deflection of the earth's magnetic field in the summer of 1991. The resulting compensation method for the natural ambient dose rate enables sensitive detection of anomalies, supporting the surveillance of nuclear installations and the management of nuclear emergency networks. (Author)

  6. Diclofenac pharmacokinetic meta-analysis and dose recommendations for surgical pain in children aged 1-12 years.

    Science.gov (United States)

    Standing, Joseph F; Tibboel, Dick; Korpela, Reijo; Olkkola, Klaus T

    2011-03-01

    Diclofenac is an effective, opiate-sparing analgesic for acute pain in children, which is commonly used in pediatric surgical units. Recently, a Cochrane review concluded the major knowledge gap in diclofenac use is dosing information. A pharmacokinetic meta-analysis has been undertaken with the aim of recommending a dose for children aged 1-12 years. Studies containing diclofenac pharmacokinetic data were identified during a Cochrane systematic review, and authors were asked to provide raw data. A pooled population analysis was undertaken in NONMEM to define the pharmacokinetics of intravenous, oral, and rectal diclofenac in children. Simulations were performed to recommend a dose yielding an equivalent area under diclofenac concentration-time curve (AUC) to a 50-mg dispersible tablet in adults. Data from 111 children aged 1-14 years consisting of 375 samples following intravenous, oral suspension, and suppositories were used. Adult dispersible tablet and suspension data were added to provide a reference AUC and support the absorption modeling, respectively. A three-compartment model described disposition, a dual-absorption compartment model was used for suspension and dispersible tablet data, and single-absorption compartment model for suppositories. The estimate of clearance was 16.5 l·h(-1) ·70 kg(-1) and bioavailabilities were 0.36, 0.63, and 0.35 for suspension, suppository, and dispersible tablets, respectively. Single doses of 0.3 mg·kg(-1) for intravenous, 0.5 mg·kg(-1) for suppositories, and 1 mg·kg(-1) for oral diclofenac in children aged 1-12 years are recommended as they yield a similar AUC to 50 mg in adults. © 2011 Blackwell Publishing Ltd.

  7. Clinical effects of chronic low doses irradiation (11 years after Chernobyl accident)

    International Nuclear Information System (INIS)

    Romanenko, A.Y.; Bebeshko, V.G.

    1997-01-01

    Estimation of clinical effects of influence low doses of irradiation as the result of the Chernobyl accident on the human organism is presented in this report. The results of the investigations are concerning to changings in different organs and systems of inhabitants of the contamination territories and among clean-up workers. Increasing of morbidity of digestive and nervous systems is notified. Increase of thyroid cancer, chronic thyroidities and hypothyreouses is resisted in clean-up workers in dynamic observation. Highly morbidity of bronchopulmonal system and blood circulation system is revealed. High level of compensative and adaptive reactions of immune and hemopoietic systems is notified. Excesses of leukemias and lymphomas in inhabitants of the contamination territories is not demonstrated but tendency for increasing quantity cases of oncohematological diseases (leukemias, lymphomas, MDS) among clean-up workers IV-VII 1986 are absent. A dynamic of health state of children injured as a result of Chernobyl accident is characterized with continues negative tendencies. (author)

  8. Booster dose after 10 years is recommended following 17DD-YF primary vaccination.

    Science.gov (United States)

    Campi-Azevedo, Ana Carolina; Costa-Pereira, Christiane; Antonelli, Lis R; Fonseca, Cristina T; Teixeira-Carvalho, Andréa; Villela-Rezende, Gabriela; Santos, Raiany A; Batista, Maurício A; Campos, Fernanda M; Pacheco-Porto, Luiza; Melo Júnior, Otoni A; Hossell, Débora M S H; Coelho-dos-Reis, Jordana G; Peruhype-Magalhães, Vanessa; Costa-Silva, Matheus F; de Oliveira, Jaquelline G; Farias, Roberto H; Noronha, Tatiana G; Lemos, Jandira A; von Doellinger, Vanessa dos R; Simões, Marisol; de Souza, Mirian M; Malaquias, Luiz C; Persi, Harold R; Pereira, Jorge M; Martins, José A; Dornelas-Ribeiro, Marcos; Vinhas, Aline de A; Alves, Tatiane R; Maia, Maria de L; Freire, Marcos da S; Martins, Reinaldo de M; Homma, Akira; Romano, Alessandro P M; Domingues, Carla M; Tauil, Pedro L; Vasconcelos, Pedro F; Rios, Maria; Caldas, Iramaya R; Camacho, Luiz A; Martins-Filho, Olindo Assis

    2016-01-01

    A single vaccination of Yellow Fever vaccines is believed to confer life-long protection. In this study, results of vaccinees who received a single dose of 17DD-YF immunization followed over 10 y challenge this premise. YF-neutralizing antibodies, subsets of memory T and B cells as well as cytokine-producing lymphocytes were evaluated in groups of adults before (NVday0) and after (PVday30-45, PVyear1-4, PVyear5-9, PVyear10-11, PVyear12-13) 17DD-YF primary vaccination. YF-neutralizing antibodies decrease significantly from PVyear1-4 to PVyear12-13 as compared to PVday30-45, and the seropositivity rates (PRNT≥2.9Log10mIU/mL) become critical (lower than 90%) beyond PVyear5-9. YF-specific memory phenotypes (effector T-cells and classical B-cells) significantly increase at PVday30-45 as compared to naïve baseline. Moreover, these phenotypes tend to decrease at PVyear10-11 as compared to PVday30-45. Decreasing levels of TNF-α(+) and IFN-γ(+) produced by CD4(+) and CD8(+) T-cells along with increasing levels of IL-10(+)CD4(+)T-cells were characteristic of anti-YF response over time. Systems biology profiling represented by hierarchic networks revealed that while the naïve baseline is characterized by independent micro-nets, primary vaccinees displayed an imbricate network with essential role of central and effector CD8(+) memory T-cell responses. Any putative limitations of this cross-sectional study will certainly be answered by the ongoing longitudinal population-based investigation. Overall, our data support the current Brazilian national immunization policy guidelines that recommend one booster dose 10 y after primary 17DD-YF vaccination.

  9. The treatment of Graves' disease with antithyroid drugs and small doses of radioiodine. About 330 cases during a 20 years period

    International Nuclear Information System (INIS)

    Jaffiol, C.; Baldet, L.; Papachristou, C.; Lavit, C.; Mirouze, J.

    1980-01-01

    Three hundred and thirty Graves' disease patients were treated by 131 I from 1961 to 1979; 57% has a goiter and 32% had exophtalmos. One or several doses of radioiodine were given to each patient without dosimetry. The mean total dose (+- SEM) was = 8.51 +- 0.44 mCi and the mean for the first dose 4.34 +- 4 ans 54.8% of the patients received only one dose but 10.3% of them had more than 3 doses. Data obtained by actuarial methods showed 66% of the cases to be in remission in less than 2 years; the frequency of hypothyroidism increased steadily by 3% every year to give 15% at 5 years and 30% at 10 years. Remission was slower to occur in goitrous subjects and hypothyroidism was less frequent in this group despite doses significantly higher of radioidine (p [fr

  10. Anti-HBs in immunized children with cuban hepatitis B vaccine and impact of booster dose after five years

    International Nuclear Information System (INIS)

    Dahifar, H.; Mousavi, F.; Ghorbani, A.

    2008-01-01

    Hepatitis B virus infection and associated diseases are a major public health problem. This study was planned to find out the persistence of antibody against hepatitis B surface antigen in Iranian vaccinated children after five years. Anti-HBs titers in a group of healthy good - responder children who were vaccinated with Cuban hepatitis B vaccine in infancy were measured after five years. Children with antibody titers <100 mlU/ml were revaccinated and retested after four weeks. Mean anti-HBs titers in 68 children (29 females, 39 males) were 482.1 mlU/ml at six months after the third dose of primary vaccination and 153 mlU/ml at five years later. Total mean anti-HBs titers in 36 (52.9%) children out of 68 (17 females, 19 males) were 38.3 mlU/ml and 4(5.8%) of 68 children (two of each sexes) had no detectable antibody after five years. Total mean anti-HBs titers in these hypo- responder and non- responder were 774.3 mlU/ml and 625.5 mlU/ml respectively after booster dose. In a group of children, who were immunized with Cuban hepatitis B vaccine from birth, anti-HBS titers fell at 6.5 years of age and almost half of children became hypo responder or no responder and their anti-HBs titers developed secondary rise after booster vaccination. All children showed immunologic memory to a booster dose. (author)

  11. Evaluation of the impact of 2 years of a dosing intervention on canine echinococcosis in the Alay Valley, Kyrgyzstan.

    Science.gov (United States)

    VAN Kesteren, F; Mastin, A; Torgerson, P R; Mytynova, Bermet; Craig, P S

    2017-09-01

    Echinococcosis is a re-emerging zoonotic disease in Kyrgyzstan. In 2012, an echinococcosis control scheme was started that included dosing owned dogs in the Alay Valley, Kyrgyzstan with praziquantel. Control programmes require large investments of money and resources; as such it is important to evaluate how well these are meeting their targets. However, problems associated with echinococcosis control schemes include remoteness and semi-nomadic customs of affected communities, and lack of resources. These same problems apply to control scheme evaluations, and quick and easy assessment tools are highly desirable. Lot quality assurance sampling was used to assess the impact of approximately 2 years of echinococcosis control in the Alay valley. A pre-intervention coproELISA prevalence was established, and a 75% threshold for dosing compliance was set based on previous studies. Ten communities were visited in 2013 and 2014, with 18-21 dogs sampled per community, and questionnaires administered to dog owners. After 21 months of control efforts, 8/10 communities showed evidence of reaching the 75% praziquantel dosing target, although only 3/10 showed evidence of a reduction in coproELISA prevalence. This is understandable, since years of sustained control are required to effectively control echinococcosis, and efforts in the Alay valley should be and are being continued.

  12. Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review

    International Nuclear Information System (INIS)

    Chawla, Soni C.; Federman, Noah; Zhang, Di; Nagata, Kristen; Nuthakki, Soujanya; McNitt-Gray, Michael; Boechat, M.I.

    2010-01-01

    The increasing use of serial PET/CT scans in the management of pediatric malignancies raises the important consideration of radiation exposure in children. To estimate the cumulative radiation dose from PET/CT studies to children with malignancy and to compare with the data in literature. Two hundred forty-eight clinical PET/CT studies performed on 78 patients (50 boys/28 girls, 1.3 to 18 years old from December 2002 to October 2007) were retrospectively reviewed under IRB approval. The whole-body effective dose (ED) estimates for each child were obtained by estimating the effective dose from each PET/CT exam performed using the ImPACT Patient Dosimetry Calculator for CT and OLINDA for PET. The average number of PET/CT studies was 3.2 per child (range: 1 to 14 studies). The average ED of an individual CT study was 20.3 mSv (range: 2.7 to 54.2), of PET study was 4.6 mSv (range: 0.4 to 7.7) and of PET/CT study was 24.8 mSv (range: 6.2 to 60.7). The average cumulative radiation dose per patient from CT studies was 64.4 mSv (range: 2.7 to 326), from PET studies was 14.5 mSv (range: 2.8 to 73) and from PET/CT studies was 78.9 mSv (range: 6.2 to 399). The radiation exposure from serial PET/CT studies performed in pediatric malignancies was considerable; however, lower doses can be used for both PET and CT studies. The ALARA principle must be applied without sacrificing diagnostic information. (orig.)

  13. Low-dose fractionated percutaneous teletherapy in age-related macular degeneration with subfoveolar neovascularization - 3 year results

    International Nuclear Information System (INIS)

    Schittkowski, M.; Schneider, H.; Guthoff, R.; Grueschow, K.; Ziegler, P.G.; Fietkau, R.

    2001-01-01

    The effect of low dose fractionated percutaneous teletherapy to visual acuity and the changes in subfoveolar neovascular membranes in age-related macular degeneration were investigated. Patients and Method: 126 eyes of 118 patients (age 55-89 years; mean 74 ys.) were treated. Best distal and near visual acuity was assessed prior to (= initial visual acuity [IVA]) and 3, 6, 12, 18, 24, and 36 months after teletherapy. Fluorescein angiography was performed prior to and 6, 12, 24 and 36 months after radiation therapy. For analysis patients were divided into different groups by IVA and membrane size. Maximal duration of observation was 36 months. Teletherapy was done by a 9-MeV photon linear accelerator through a lateral port in half-beam technique with a single dose of 2 Gy up to a total dose of 20 Gy within 12 days. Results: No severe negative side effects have been observed. Eight patients reported of epiphora and four patients complained of transient sicca syndrome. Visual acuity decreased more than one line in the group IVA 0.05-0.2. The group IVA 0.3-0.5 remained unchanged for 1 year. We found a tendency for increased visual acuity in group IVA ≥ 0.6 for 18 months. After that time both groups showed decreased visual acuity, but all these patients reported of reduced metamorphopsia and increased color and contrast perception. Conclusions: There is an influence of low dose fractionated percutaneous teletherapy on visual acuity, subfoveal neovascular membranes and metamorphopsia. IVA and duration of anamnesis play an important role. There seems to be no persistent effect; possibly increased dosage will bring a benefit. (orig.) [de

  14. Conventional external beam radiation therapy and high dose rate afterloading brachytherapy as a boost for patients older than 70 years

    International Nuclear Information System (INIS)

    Pellizzon, Antonio Cassio Assis; Salvajoli, Joao Vitor; Fogaroli, Ricardo Cesar; Novaes, Paulo Eduardo R.S.; Maia, Maria Aparecida Conte; Ferrigno, Robson

    2005-01-01

    The treatment options for patients with non metastatic prostate cancer range from observation, radical prostatectomy, radiation therapy, hormonal therapy to various combination of some to all of them. Objective: we evaluated the impact on biochemical control of disease (bNED), acute and late intestinal (GI) and urological (GU) morbidity for a group of patients older than 70 years presenting initial or locally advanced prostate cancer treated with fractionated high dose rate brachytherapy (HDRB) as a boost to conventional external beam radiation therapy (RT) at the Department of Radiation Oncology from Hospital do Cancer A. C. Camargo, Sao Paulo, Brazil. Methods: a total of 56 patients older than 70 were treated from March, 1997 to June, 2002. All patients had prior to HDRB a course of RT to a median dose of 45 Gy. HDRB doses ranged from 16 Gy to 20 Gy, given in 4 fractions. Results: the median age of the patients was 74.4 years (range 70-83) and the median follow-up 33 months (range 24 to 60). The 5-year actuarial bNED rate was 77%. Acute GU and GI morbidity G1-2 were seen in 17.8% and 7.1% of patients, respectively. Late G1 or G2 GU morbidity was seen in 10.7% of the patients, while late G3 morbidity was observed in 7.1% of the patients, represented by urethral strictures. Conclusion: this group of patients had similar bNED rates when compared to literature, with acceptable morbidity rates. (author)

  15. Accelerated partial breast irradiation in the elderly: 5-year results of high-dose rate multi-catheter brachytherapy

    International Nuclear Information System (INIS)

    Genebes, Caroline; Hannoun-Levi, Jean-Michel; Chand, Marie-Eve; Gal, Jocelyn; Gautier, Mathieu; Raoust, Ines; Ihrai, Tarik; Courdi, Adel; Ferrero, Jean-Marc; Peyrottes, Isabelle

    2014-01-01

    To evaluate clinical outcome after accelerated partial breast irradiation (APBI) in the elderly after high-dose-rate interstitial multi-catheter brachytherapy (HIBT). Between 2005 and 2013, 70 patients underwent APBI using HIBT. Catheter implant was performed intra or post-operatively (referred patients) after lumpectomy and axillary sentinel lymph node dissection. Once the pathological results confirmed the indication of APBI, planification CT-scan was performed to deliver 34 Gy/10f/5d or 32 Gy/8f/4d. Dose-volume adaptation was manually achieved (graphical optimization). Dosimetric results and clinical outcome were retrospectively analyzed. Physician cosmetic evaluation was reported. With a median follow-up of 60.9 months [4.6 – 90.1], median age was 80.7 years [62 – 93.1]. Regarding APBI ASTRO criteria, 61.4%, 18.6% and 20% were classified as suitable, cautionary and non-suitable respectively. Axillary sentinel lymph node dissection was performed in 94.3%; 8 pts (11.5%) presented an axillary involvement. A median dose of 34 Gy [32 – 35] in 8 to 10 fractions was delivered. Median CTV was 75.2 cc [16.9 – 210], median D90 EQD2 was 43.3 Gy [35 – 72.6] and median DHI was 0.54 [0.19 – 0.74]. One patient experienced ipsilateral recurrence (5-year local free recurrence rate: 97.6%. Five-year specific and overall survival rates were 97.9% and 93.2% respectively. Thirty-four patients (48%) presented 47 late complications classified grade 1 (80.8%) and grade 2 (19.2%) with no grade ≥ 3. Cosmetic results were considered excellent/good for 67 pts (95.7%). APBI using HIBT and respecting strict rules of implantation and planification, represents a smart alternative between no post-operative irradiation and whole breast irradiation delivered over 6 consecutive weeks

  16. 1977 flywheel technology symposium proceedings. [Fifty-two papers

    Energy Technology Data Exchange (ETDEWEB)

    Chang, G.C.; Stone, R.G. (eds.)

    1978-03-01

    Fifty-two papers, four paper abstracts, and four brief summaries of panel discussions are presented on flywheel energy storage technology. A separate abstract was prepared for each of 41 papers for inclusion in DOE Energy Research Abstracts (ERA). Eleven papers were processed previously for inclusion in the data base. (PMA)

  17. A seasonal variation of the three Leading diagnoses over fifty ...

    African Journals Online (AJOL)

    A seasonal variation of the three Leading diagnoses over fifty months at the Duk Lost. Boys Clinic, South Sudan reed, williama, Dannan, Tomb, Friedman Danielc, MD, Manyok gabrield, Connor Barbarae, MD, reed Davidf, MD. Introduction. The Duk Lost Boys Clinic, a Primary Health Care Clinic in Duk Payuel, is the only ...

  18. Fifty Cases of Parkinson's Disease Treated by Acupuncture Combined with Madopar

    Institute of Scientific and Technical Information of China (English)

    REN Xiao-ming

    2008-01-01

    objective;To search for an effective therapy for trealing motor disorder due to Parkinson's disease(PD).Methods;Fifty cases in a treatrnent group were treated by acupuncture combined with madopar,and 30 cases in a control group treated by madopar only.Results;A total effective rate of 92%was achieved with obvious alleviation of motor disorder in the treatment group,which was significantly higher than that in the control group(P<0.05).Conclusion;Acupuncture can enhance therapeutic effects of western medicine and lessen the dose of the medicine needed.

  19. Sexist Attitudes Among Emerging Adult Women Readers of Fifty Shades Fiction.

    Science.gov (United States)

    Altenburger, Lauren E; Carotta, Christin L; Bonomi, Amy E; Snyder, Anastasia

    2017-02-01

    Stereotypical sexist representations of men and women in popular culture reinforce rigid views of masculinity (e.g., males as being strong, in control, masterful, and aggressive) and femininity (e.g., women as being fragile and weak, unassertive, peaceful, irrational, and driven by emotions). The present study examined associations between the fictional series Fifty Shades-one popular culture mechanism that includes pervasive traditional gender role representations-and underlying sexist beliefs among a sample of 715 women ages 18-24 years. Analyses revealed associations between Fifty Shades readership and sexism, as measured through the Ambivalent Sexism Inventory. Namely women who reported reading Fifty Shades had higher levels of ambivalent, benevolent, and hostile sexism. Further, those who interpreted Fifty Shades as "romantic" had higher levels of ambivalent and benevolent sexism. Our findings support prior empirical studies noting associations between interacting with aspects of popular culture, such as television and video games, and individual beliefs and behaviors.

  20. Factors influencing the success of radio-iodine dose in the treatment of Graves disease: one year outcome

    International Nuclear Information System (INIS)

    Kamoun, T.; Sfar, R.; Regaieg, H.; Toumi, A.; Zanzouri, H.; Nouira, M.; Ben Fredj, M.; Ayachi, N.; Chatti, K.; Guezguez, M.; Essabbah, H.; Sakly, N.

    2015-01-01

    Full text of publication follows. Aim: radioiodine ( 131 I) is increasingly used as the definitive treatment of Graves disease (GD). Many factors influence the curative effects of the 131 I, thus there are some difficulties to define the optimal dose of 131 I for the treatment of GD. The purpose of our study is to evaluate the factors influencing the success rate in patients having GD and treated with radioiodine dose modulated by thyroid mass. Materials and methods: this is a prospective study of 86 patients (aged 43 ± 11, 58 women and 28 men) treated for Graves disease by radioiodine during the year 2011 in Nuclear Medicine department CHU Sahloul, Sousse. Radioiodine dose are modulated by thyroid mass: 370 MBq, 444 MBq and 555 MBq respectively for mass strictly less than 30 g, between 30 g and 40 g and greater than to 40 g. Some patients received more than 555 MBq for other causes to reach hypothyroidism precociously. The thyroid function outcome (hyperthyroidism or euthyroidism/hypothyroidism) was verified 6 months and 1 year after 131 I treatment. Patient gender, age, ophthalmopathy, thyroid size, antithyroid drugs used prior to 131 I treatment and anti-TSH receptor antibodies (TRAb), anti-thyroid peroxidase antibodies (ATPO) and anti-thyroglobulin antibodies (ATG) plasma concentrations before 131 I treatment were studied as potential interference factors for 131 I treatment success. Results: Thirty patients received 370 MBq, 29 received 444 MBq, 14 received 555 MBq and 13 more than 555 MBq. Outcome after treatment was determined in a total of 66 patients at 6 months and 63 at one year. Post-therapy follow-up revealed that treatment failed in 29% of the patients at 6 months and in 20% of patients at one year. No correlation was noted between the outcome of treatment and age, sex, ophthalmopathy, antithyroid drugs taking and ATG titer. A significant correlation was noted between the disease outcome at one year and TRAb titer: High TRAb levels are associated

  1. Late toxicity and five year outcomes after high-dose-rate brachytherapy as a monotherapy for localized prostate cancer

    International Nuclear Information System (INIS)

    Ghadjar, Pirus; Oesch, Sebastian L; Rentsch, Cyrill A; Isaak, Bernhard; Cihoric, Nikola; Manser, Peter; Thalmann, George N; Aebersold, Daniel M

    2014-01-01

    To determine the 5-year outcome after high-dose-rate brachytherapy (HDR-BT) as a monotherapy. Between 10/2003 and 06/2006, 36 patients with low (28) and intermediate (8) risk prostate cancer were treated by HDR-BT monotherapy. All patients received one implant and 4 fractions of 9.5 Gy within 48 hours for a total prescribed dose (PD) of 38 Gy. Five patients received concomitant androgen deprivation therapy (ADT). Toxicity was scored according to the common terminology criteria for adverse events from the National Cancer Institute (CTCAE) version 3.0. Biochemical recurrence was defined according to the Phoenix criteria and analyzed using the Kaplan Meier method. Predictors for late grade 3 GU toxicity were analyzed using univariate and multivariate Cox regression analyses. The median follow-up was 6.9 years (range, 1.5-8.0 years). Late grade 2 and 3 genitourinary (GU) toxicity was observed in 10 (28%) and 7 (19%) patients, respectively. The actuarial proportion of patients with late grade 3 GU toxicity at 5 years was 17.7%. Late grade 2 and 3 gastrointestinal (GI) toxicities were not observed. The crude erectile function preservation rate in patients without ADT was 75%. The 5 year biochemical recurrence-free survival (bRFS) rate was 97%. Late grade 3 GU toxicity was associated with the urethral volume (p = 0.001) and the urethral V 120 (urethral volume receiving ≥120% of the PD; p = 0.0005) after multivariate Cox regression. After HDR-BT monotherapy late grade 3 GU was observed relatively frequently and was associated with the urethral V 120 . GI toxicity was negligible, the erectile function preservation rate and the bRFS rate was excellent

  2. Accelerated partial-breast irradiation using high-dose-rate interstitial brachytherapy: 12-year update of a prospective clinical study

    International Nuclear Information System (INIS)

    Polgar, Csaba; Major, Tibor; Fodor, Janos; Sulyok, Zoltan; Somogyi, Andras; Loevey, Katalin; Nemeth, Gyoergy; Kasler, Miklos

    2010-01-01

    Background and purpose: To report the 12-year updated results of accelerated partial-breast irradiation (APBI) using multicatheter interstitial high-dose-rate (HDR) brachytherapy (BT). Patients and methods: Forty-five prospectively selected patients with T1N0-N1mi, nonlobular breast cancer without the presence of an extensive intraductal component and with negative surgical margins were treated with APBI after breast-conserving surgery (BCS) using interstitial HDR BT. A total dose of 30.3 Gy (n = 8) and 36.4 Gy (n = 37) in seven fractions within 4 days was delivered to the tumour bed plus a 1-2 cm margin. The median follow-up time was 133 months for surviving patients. Local and regional control, disease-free (DFS), cancer-specific (CSS), and overall survival (OS), as well as late side effects, and cosmetic results were assessed. Results: Four (8.9%) ipsilateral breast tumour recurrences were observed, for a 5-, 10-, and 12-year actuarial rate of 4.4%, 9.3%, and 9.3%, respectively. A total of two regional nodal failures were observed for a 12-year actuarial rate of 4.4%. The 12-year DFS, CSS, and OS was 75.3%, 91.1%, and 88.9%, respectively. Grade 3 fibrosis was observed in one patient (2.2%). No patient developed grade 3 teleangiectasia. Fat necrosis requiring surgical intervention occurred in one woman (2.2%). Cosmetic results were rated excellent or good in 35 patients (77.8%). Conclusions: Twelve-year results with APBI using HDR multicatheter interstitial implants continue to demonstrate excellent long-term local tumour control, survival, and cosmetic results with a low-rate of late side effects.

  3. Sustained Antibody Responses 6 Years Following 1, 2, or 3 Doses of Quadrivalent Human Papillomavirus (HPV) Vaccine in Adolescent Fijian Girls, and Subsequent Responses to a Single Dose of Bivalent HPV Vaccine: A Prospective Cohort Study.

    Science.gov (United States)

    Toh, Zheng Quan; Russell, Fiona M; Reyburn, Rita; Fong, James; Tuivaga, Evelyn; Ratu, Tupou; Nguyen, Cattram D; Devi, Rachel; Kama, Mike; Matanitobua, Silivia; Tabrizi, Sepehr N; Garland, Suzanne M; Sinha, Rohit; Frazer, Ian; Tikoduadua, Lisi; Kado, Joseph; Rafai, Eric; Mulholland, Edward K; Licciardi, Paul V

    2017-04-01

    The duration of antibody response following reduced human papillomavirus (HPV) vaccine doses has not been determined. We compared the antibody responses in girls previously vaccinated with zero, 1, 2, or 3 doses of quadrivalent HPV vaccine (4vHPV; Gardasil, Merck) 6 years previously. A prospective cohort study was undertaken in 200 Fijian girls 15-19 years of age. Approximately equal numbers of girls from 2 main ethnic groups (Fijians of Indian descent [FID] and Indigenous Fijians [iTaukei]) in Fiji were recruited for each dosage groups. Blood was drawn before and 28 days following a single dose of bivalent HPV vaccine (2vHPV; Cervarix, GlaxoSmithKline). We measured neutralizing antibodies (NAb) against HPV-6, -11, -16, and -18 using the pseudovirion-based neutralization assay. After 6 years (before a dose of 2vHPV was given), the geometric mean NAb titers for all 4 HPV types were not statistically different between 2-dose (2D) and 3-dose (3D) recipients: HPV-6 (3D: 2216 [95% confidence interval {CI},1695-2896]; 2D: 1476 [95% CI, 1019-2137]; P = .07), HPV-11 (3D: 4431 [95% CI, 3396-5783]; 2D: 2951 [95% CI, 1984-4390]; P = .09), HPV-16 (3D: 3373 [95% CI, 2511-4530]; 2D: 3275 [95% CI, 2452-4373]; P = .89); HPV-18 (3D: 628 [95% CI: 445-888]; 2D: 606 [95% CI, 462-862]; P = .89), and were higher in FID than iTaukei girls. Although 1-dose recipients had significantly lower NAb titers than 2-/3-dose recipients, their NAb titers were 5- to 30-fold higher than unvaccinated girls. Post-2vHPV NAb titers against HPV-16 and -18 were not statistically different between girls who received 1, 2, or 3 doses of 4vHPV previously. Two doses of 4vHPV provide similar NAb titers as 3 doses for 6 years, although the clinical significance is unknown. A single dose of 4vHPV elicits antibodies that persisted for at least 6 years, and induced immune memory, suggesting possible protection against HPV vaccine types after a single dose of 4vHPV. © The Author 2016. Published by Oxford University

  4. Low-dose CT pulmonary angiography on a 15-year-old CT scanner: a feasibility study

    Directory of Open Access Journals (Sweden)

    Moritz Kaup

    2016-12-01

    Full Text Available Background Computed tomography (CT low-dose (LD imaging is used to lower radiation exposure, especially in vascular imaging; in current literature, this is mostly on latest generation high-end CT systems. Purpose To evaluate the effects of reduced tube current on objective and subjective image quality of a 15-year-old 16-slice CT system for pulmonary angiography (CTPA. Material and Methods CTPA scans from 60 prospectively randomized patients (28 men, 32 women were examined in this study on a 15-year-old 16-slice CT scanner system. Standard CT (SD settings were 100 kV and 150 mAs, LD settings were 100 kV and 50 mAs. Attenuation of the pulmonary trunk, various anatomic landmarks, and image noise were quantitatively measured; contrast-to-noise ratios (CNR and signal-to-noise ratios (SNR were calculated. Three independent blinded radiologists subjectively rated each image series using a 5-point grading scale. Results CT dose index (CTDI in the LD series was 66.46% lower compared to the SD settings (2.49 ± 0.55 mGy versus 7.42 ± 1.17 mGy. Attenuation of the pulmonary trunk showed similar results for both series (SD 409.55 ± 91.04 HU; LD 380.43 HU ± 93.11 HU; P = 0.768. Subjective image analysis showed no significant differences between SD and LD settings regarding the suitability for detection of central and peripheral PE (central SD/LD, 4.88; intra-class correlation coefficients [ICC], 0.894/4.83; ICC, 0.745; peripheral SD/LD, 4.70; ICC, 0.943/4.57; ICC, 0.919; all P > 0.4. Conclusion The LD protocol, on a 15-year-old CT scanner system without current high-end hardware or post-processing tools, led to a dose reduction of approximately 67% with similar subjective image quality and delineation of central and peripheral pulmonary arteries.

  5. Comparative Assessment of a Single Dose and a 2-dose Vaccination Series of a Quadrivalent Meningococcal CRM-conjugate Vaccine (MenACWY-CRM) in Children 2-10 Years of Age.

    Science.gov (United States)

    Johnston, William; Essink, Brandon; Kirstein, Judith; Forleo-Neto, Eduardo; Percell, Sandra; Han, Linda; Keshavan, Pavitra; Smolenov, Igor

    2016-01-01

    We compared the immunogenicity, safety and 1-year antibody persistence of a single-dose and a 2-dose series of a licensed meningococcal ACWY-CRM conjugate vaccine (MenACWY-CRM) in 2- to 10-year-old children. In this phase III, multicenter, observer-blind study, children aged 2-5 years (n = 359) and 6-10 years (n = 356) were randomized 1:1 to receive 2 doses of MenACWY-CRM (ACWY2) or 1 dose of placebo followed by 1 dose of MenACWY-CRM (ACWY1), 2 months apart. Immunogenicity was measured using serum bactericidal activity with human complement (hSBA). Primary outcomes were to assess the immunologic noninferiority and superiority of ACWY2 versus ACWY1. One-month after the second dose, the hSBA seroresponse in ACWY2 was noninferior to ACWY1 for all 4 serogroups, in both age cohorts, and was superior for serogroups C and Y in the 2- to 5-year-old age cohort and for serogroup Y in the 6- to 10-year-old age cohort. Overall, 90%-99% of subjects in ACWY2 and 65%-96% in ACWY1 had hSBA titers ≥ 8; geometric mean titers were 1.8- to 6.4-fold higher in ACWY2 than ACWY1 across serogroups. At 1 year postvaccination, geometric mean titers declined, and the differences between ACWY2 and ACWY1 remained significant for serogroups A and C in the 2- to 5-year-old age cohort and for serogroups C and Y in the 6- to 10-year-old age cohort. The safety profile of MenACWY-CRM was similar in both groups. The single dose and 2-dose MenACWY-CRM series were immunogenic and well tolerated. Although antibody responses were greater after 2 doses, especially in the 2- to 5-year-old age cohort, this difference was less pronounced at 1 year postvaccination.

  6. In vivo dosimetry with semiconducting diodes for dose verification in total-body irradiation. A 10-year experience

    International Nuclear Information System (INIS)

    Ramm, U.; Licher, J.; Moog, J.; Scherf, C.; Kara, E.; Boettcher, H.D.; Roedel, C.; Mose, S.

    2008-01-01

    Background and purpose: for total-body irradiation (TBI) using the translation method, dose distribution cannot be computed with computer-assisted three-dimensional planning systems. Therefore, dose distribution has to be primarily estimated based on CT scans (beam-zone method) which is followed by in vivo measurements to ascertain a homogeneous dose delivery. The aim of this study was to clinically establish semiconductor probes as a simple and fast method to obtain an online verification of the dose at relevant points. Patients and methods: in 110 consecutively irradiated TBI patients (12.6 Gy, 2 x 1.8 Gy/day), six semiconductor probes were attached to the body surface at dose-relevant points (eye/head, neck, lung, navel). The mid-body point of the abdomen was defined as dose reference point. The speed of translation was optimized to definitively reach the prescribed dose in this point. Based on the entrance and exit doses, the mid-body doses at the other points were computed. The dose homogeneity in the entire target volume was determined comparing all measured data with the dose at the reference point. Results: after calibration of the semiconductor probes under treatment conditions the dose in selected points and the dose homogeneity in the target volume could be quantitatively specified. In the TBI patients, conformity of calculated and measured doses in the given points was achieved with small deviations of adequate accuracy. The data of 80% of the patients are within an uncertainty of ± 5%. Conclusion: during TBI using the translation method, dose distribution and dose homogeneity can be easily controlled in selected points by means of semiconductor probes. Semiconductor probes are recommended for further use in the physical evaluation of TBI. (orig.)

  7. Persistence of immunity from 1 year of age after one or two doses of hepatitis A vaccine given to children in Argentina

    Directory of Open Access Journals (Sweden)

    Espul C

    2012-08-01

    Full Text Available Carlos Espul,1 Laura Benedetti,2 Héctor Cuello,3 Guy Houillon,4 Anvar Rasuli41Programa de Lucha Contra las Hepatitis Virales, Ministerio de Salud/Hospital Central de Mendoza, 2Programa Provincial de Inmunizaciones, Ministerio de Salud, 3Laboratorio de Virología, Hospital Central de Mendoza, Mendoza, Argentina; 4Sanofi Pasteur, Lyon, FranceBackground: This study was done to determine the immunogenicity of a single dose of hepatitis A vaccine in children, providing needed clinical data on the flexibility of booster administration.Methods: Participants had received one dose of inactivated hepatitis A vaccine (Avaxim™ 80 U Pediatric at 12–23 months of age or two doses of the same vaccine at 12 and 18 months of age prior to enrolment. Anti-hepatitis A antibody concentrations were measured at the first, second, and third year after vaccination. Suspected cases of hepatitis A in participant families were assessed and family socioeconomic data were collected.Results: A series of 546 participants were enrolled. Of 467 (85.5% participants completing 3 years of follow-up, 365 had received a single vaccine dose and 94 had received two vaccine doses. Seropositivity (anti-HAV ≥ 10 mIU/mL at 3 years was 99.7% after one dose and 100% after two doses. At one year, geometric mean concentrations were higher after two doses (1433.9 mIU/mL, 95% confidence interval [CI] 1108–1855 than one (209.7 mIU/mL, 95% CI 190.6–230.6. Geometric mean concentrations decreased in both groups during the study, but remained well above 10 mIU/mL through the third year. The geometric mean of 3-year to one-year anti-hepatitis A concentration ratios was 0.74 (95% CI 0.70–0.79 following one dose and 0.57 (95% CI 0.47–0.70 following two doses. The greatest decrease in geometric mean concentrations occurred during the third year, ie, 21.2% in the one-dose group and 40.8% in the two-dose group. Six participants became seronegative during follow-up and responded strongly to a

  8. Estimate of the internal doses received by the population of Bucharest due to 137 Cs and 90 Sr intake in the first five years after the Chernobyl accident

    International Nuclear Information System (INIS)

    Toader, Maria; Vasilache, R. A.

    1995-01-01

    The evolution of the 137 Cs and 90 Sr daily intake between April 1986 and March 1991 as well as the internal doses resulting from ingestion of contaminated food is presented for a group of adults living in Bucharest. The results indicate that the effective doses due to 137 Cs and 90 Sr dietary intake had the highest values in the first year after the Chernobyl accident, namely, 796 μSv as a result of 137 Cs dietary intake and 23 μSv as a result of the 90 Sr dietary intake. The effective doses committed annually due to the Caesium-137 dietary intake decreased very fast from 796 μSv committed in the first year after the accident to 7.3 μSv committed in the fifth year after the accident. Although the effective dose committed in the first year after the accident due to the Strontium-90 dietary intake was much smaller than the dose due to the Caesium-137 (23 μSv), the decrease was slower so that the effective dose committed in the fifth year after the accident due to the Strontium-90 dietary intake was 7.5 μSv. (authors)

  9. Primary treatment of endometrial carcinoma with high-dose-rate brachytherapy: results of 12 years of experience with 280 patients

    International Nuclear Information System (INIS)

    Knocke, Tomas H.; Kucera, Herwig; Weidinger, Barbara; Hoeller, Walpurga; Poetter, Richard

    1997-01-01

    Purpose: This study aimed to evaluate the efficacy of high-dose-rate brachytherapy (HDRB) in the primary treatment of endometrial carcinoma. The results of 12 years of experience (1981-1992) covering 280 patients (mean age 72 years) and their follow-up over 10 years (mean 55 months) are reported. Methods and Materials: Staging was based on clinical examination and fractionated curettage. There were 116 patients in clinical Stage Ia, 119 in Stage Ib, 37 in Stage II, and 8 in Stage III. HDRB was performed four to five times (8.5 Gy) with a one-channel intracavitary applicator and one to two times (7 Gy) with an intravaginal cylinder applicator. Overall and disease-specific survival, local control according to stage and histology, and late side effects were analyzed retrospectively (actuarial method). Results: At 5 years, overall survival, disease-specific survival, and local control were 52.7%, 76.6%, and 75.4% (Stage Ia: 63.9%, 84.9%, and 86.0%; Stage Ib: 47.3%, 73.3%, and 68.8%; and Stage II: 40.2%, 68.6%, and 60.5%) according to histopathologic Grade 1: 65.1%, 83.5%, and 77.7%; for Grade 2: 44.7%, 75.4%, and 75.8%; and for Grade 3: 37.7%, 63.9%, and 74.1%. Eight patients showed progressive disease, 64 developed recurrence after a median of 13 months (45 of whom had a local recurrence only, and 6 of whom had a local recurrence with distant metastases), 6 developed a lymph node recurrence only, and 7 developed distant metastases only. The calculated probability for developing a Grade III late side effect was 5.2% at 5 years. Conclusion: At Stages Ia, Ib, and II in endometrial carcinoma, HDRB is a very effective treatment modality with acceptable local control rates and disease-specific survival for patients who are not fit for surgery. During the time frame of 12 years and in 280 patients the method has proven to have a low risk of acute complications and an acceptable risk of long-term side effects

  10. Dosimetric evaluation in organs of the Tc99m, I123 bio-kinetics to estimate dose in thyroid children 1 and 5 years

    International Nuclear Information System (INIS)

    Vasquez, A. M.; Quispe, R.; Vasquez, D. J.; Rocha, M. D.; Morales, N. R.; Marin, R. K.; Zelada, A. L.

    2012-10-01

    Using the formalism MIRD and the representation of Cristy-Eckerman for the thyroid in children of 1 and 5 years, is demonstrated that the dosimetric contribution of the organs of I 123 (iodure) bio-kinetics is not significant in the dose estimate. The total dose absorbed by the gland is its auto dose. The dosimetric contribution of the organs source of the Tc 99m (pertechnetate) bio-kinetics in the gland is significant in the dose estimate like to be ignored. The reported results for the iodure are not significantly different to the found for the Marinelli scheme (auto-dose) for thyroid represented by a sphere of 1,78 and 3,45 grams. (Author)

  11. Assessment of the Annual Additional Effective Doses amongst Minamisoma Children during the Second Year after the Fukushima Daiichi Nuclear Power Plant Disaster.

    Science.gov (United States)

    Tsubokura, Masaharu; Kato, Shigeaki; Morita, Tomohiro; Nomura, Shuhei; Kami, Masahiro; Sakaihara, Kikugoro; Hanai, Tatsuo; Oikawa, Tomoyoshi; Kanazawa, Yukio

    2015-01-01

    An assessment of the external and internal radiation exposure levels, which includes calculation of effective doses from chronic radiation exposure and assessment of long-term radiation-related health risks, has become mandatory for residents living near the nuclear power plant in Fukushima, Japan. Data for all primary and secondary children in Minamisoma who participated in both external and internal screening programs were employed to assess the annual additional effective dose acquired due to the Fukushima Daiichi nuclear power plant disaster. In total, 881 children took part in both internal and external radiation exposure screening programs between 1st April 2012 to 31st March 2013. The level of additional effective doses ranged from 0.025 to 3.49 mSv/year with the median of 0.70 mSv/year. While 99.7% of the children (n = 878) were not detected with internal contamination, 90.3% of the additional effective doses was the result of external radiation exposure. This finding is relatively consistent with the doses estimated by the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). The present study showed that the level of annual additional effective doses among children in Minamisoma has been low, even after the inter-individual differences were taken into account. The dose from internal radiation exposure was negligible presumably due to the success of contaminated food control.

  12. Considerations about soil decontamination in Goiania: doses the population at the first year and at long date

    International Nuclear Information System (INIS)

    Amaral, E.C.S.; Vianna, M.E.C.M.; Godoy, J.M.; Rochedo, E.R.R.; Campos, M.J.; Oliveira, J.P.; Reis, W.G.; Pires do Rio, M.A.; Pereira, J.C.A.; Romeiro, C.H.; Ramos Junior, A.C.

    1988-01-01

    Values of the order of 10 4 to 10 5 Bq/Kg for the Cs-137 specific activity were observed for soils from regions within a radius of about 50 meters around the main focus. The dissemination was done by the wind and further deposition. However, it was also observed the disposal of contaminated housewaste at unused gardens nearby. It was found the soil profiles as an adequated method for decision on the soil layer to be removed. The in-soil Cs-137 migration presented the same shape whatever the specific activity deposited at the surface and in average 30% of the total activity has remained at the upper 1.5 cm layer over the first five months after the accident. The limits and procedures that have been adopted ensure a total dose to the critical group below 4 mSv for the first year and 0.68 mSv/a in average over the life-time above background. (author) [pt

  13. Young age under 60 years is not a contraindication to treatment with definitive dose escalated radiotherapy for prostate cancer

    International Nuclear Information System (INIS)

    Klayton, Tracy L.; Ruth, Karen; Horwitz, Eric M.; Uzzo, Robert G.; Kutikov, Alexander; Chen, David Y.T.; Sobczak, Mark; Buyyounouski, Mark K.

    2011-01-01

    Background: It is widely believed that younger prostate cancer patients are at greater risk of recurrence following radiotherapy (RT). Methods: From 1992 to 2007, 2168 (395 age ⩽60) men received conformal RT alone for prostate cancer at our institution (median dose = 76 Gy, range: 72–80). Multivariable analysis (MVA) was used to identify significant predictors for BF and PCSM. Cumulative incidence was estimated using the competing risk method (Fine and Gray) for BF (Phoenix definition) and PCSM to account for the competing risk of death. Results: With a median follow-up of 72.2 months (range: 24.0–205.1), 8-year BF was 27.1% for age ⩽60 vs. 23.7% for age >60 (p = 0.29). Eight-year PCSM was 3.0% for age ⩽60 vs. 2.0% for age >60 (p = 0.52). MVA for BF identified initial PSA [adjusted HR = 1.7 (PSA 10–20), 2.6 (PSA >20), p 12 months), p < 0.01] as significant, but not age or ADT <12 months. MVA for PCSM identified Gleason score [adjusted HR = 3.0 (G8–10), p = 0.01] and T-stage [adjusted HR = 8.7 (T3-4), p < 0.01] as significant, but not age, PSA, or ADT. Conclusion: This is the largest, most mature study of younger men treated with RT for prostate cancer that confirms young age is not prognostic for BF.

  14. Nuclear magnetic resonance evaluation of fifty children with cancer

    International Nuclear Information System (INIS)

    Cohen, M.D.; Klatte, E.C.; Smith, J.A.; Carr, B.E.; Martin-Simmerman, P.

    1985-01-01

    Fifty children with cancer have been studied by MR. The patients studied include ten with lymphoma, nine with neuroblastoma, five with rhabdomyosarcoma, six with leukemia, five with Ewings sarcoma, four with Wilms tumor and several with other miscellaneous tumors. The results of scanning show that MR is well tolerated by children. Primary tumor has been identified in every case. Metastases have been identified in many patients. MR has proved helpful in identifying the organ of origin of a tumor. Because of excellent vessel visualization it is helpful in planning surgical resection of a tumor. In addition, in a number of patients MR has proved helpful in monitoring the response of tumor to nonsurgical therapy. With continued improvement in image quality it is believed that MR has a major role to play in pediatric tumor imaging [fr

  15. The decision book fifty models for strategic thinking

    CERN Document Server

    Krogerus, Mikael

    2011-01-01

    Most of us face the same questions every day: What do I want? And how can I get it? How can I live more happily and work more efficiently? A worldwide bestseller, The Decision Book distils into a single volume the fifty best decision-making models used on MBA courses and elsewhere that will help you tackle these important questions - from the well known (the Eisenhower matrix for time management) to the less familiar but equally useful (the Swiss Cheese model). It will even show you how to remember everything you will have learned by the end of it. Stylish and compact, this little black book is a powerful asset. Whether you need to plot a presentation, assess someone's business idea or get to know yourself better, this unique guide will help you simplify any problem and take steps towards the right decision.

  16. Individual doses control in the units of ministry of defence and ministry of interior and administration in the years 1986 - 2000

    International Nuclear Information System (INIS)

    Jazwinski, J.; Nowosielska, E.M.; Janiak, M.K.

    2003-01-01

    The aim of presented work was the assessment of occupational radiation exposure and its distribution among the workers of Ministry of Defence and Ministry of Interior and Administration in the years 1986 - 2000. the research was conducted on the basis of data collected by Laboratory of Radiological Inspection and Individual Doses Control, Department of Radiation Protection and Radiobiology Military Institute of Hygiene and Epidemiology, Warsaw, Poland. The workers occupationally exposed to radiation were divided into following groups: government department (Ministry of Defence or Ministry of Interior and Administration), according to the age (below 25, 26-35, 36-45, 46-55 and above 56 years old), sex, education, (elementary, secondary, university) or job (doctors, nurses, rtg technicians, etc.). The number of workers covered with individual doses control changed in Ministry of Defence from 689 (in 1986) to 1030 (in 2000), and in Ministry of Interior and Administration from 261 to 924 in the same period. The percent of workers, who received doses below 2 mSv per year varied in Ministry of Defence from 91,6% (in 1997) to 99,4% (in 1990), and in Ministry of Interior and Administration from 96,8% (in 1993) to 99,4 (in 2000). Almost 99% of workers occupationally exposed to radiation and covered with individual doses control received doses below 15 mSv, irrespective of year or department. The analysis of collected data revealed, that for a large majority of occupationally exposed workers the risk arising from contact with ionizing radiation is minimal (over 99% of workers covered with individual doses control received doses below 2 mSv per year), however there are critical groups of workers, for which the received equivalent doses were about 30 - 50 mSv. Increased doses of radiation, however not exceeding obligatory limits, are noticed for workers taking part in surgical operations in X radiation field, urologic operations and diagnostic and or working on several

  17. Paediatric radiology and scientific contributions to radiation dose at the meeting of the German Radiological Society-An analysis of an 11-year period

    International Nuclear Information System (INIS)

    Heyer, Christoph M.; Lemburg, Stefan P.; Peters, Soeren A.

    2010-01-01

    Aim: Evaluation of the emphasis on themes pertaining to paediatric radiology and radiation dose at the Meeting of the German Radiological Society from 1998 to 2008 in comparison to international data. Materials and methods: Retrospective analysis of 9440 abstracts with documentation of type of contribution, imaging modality, and examined body region. Abstracts primarily dealing with paediatric radiology and those stating radiation dose were documented. Results were compared with a Pubmed query. Results: 448 contributions in paediatric radiology were presented corresponding to 5% of all abstracts with an increase from 5 (1998) to 7% (2008). The proportion of prospective studies of all congress contributions was 10%, whereas in paediatric radiology, the share of prospective studies was 6%. From 1998 to 2008, the share of MRI fell from 48 to 38%, while CT contributions rose from 30 to 34%. Within paediatric radiology, the proportion of CT rose from 23 to 29%, while MRI and ultrasound fell from 63 to 48% and 35 to 19%, respectively. The share of abstracts dealing with radiation dose rose from 7 to 10% while that primarily pertaining to dose reduction grew from 2 to 4%. Of all abstracts concerning CT, 15% touched on radiation dose, whereas 6% primarily dealt with dose reduction. Among all abstracts dealing with paediatric radiology, 20 and 6% mentioned radiation dose and dose reduction, respectively. In the subgroup of paediatric radiology CT abstracts, radiation dose and dose reduction were mentioned in 34 and 16%, respectively. An online query produced 137,791 publications on CT, of whose abstracts 3% mentioned radiation dose and 0.5% mentioned dose reduction. 11% of all CT publications dealt with paediatric populations and 2% of these publications examined questions of radiation dose. Conclusions: In the last 11 years the Meeting of the German Radiological Society has presented a growing number of contributions pertaining to paediatric radiology. CT has shown the

  18. Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis: A Two-Year Pilot Study

    Directory of Open Access Journals (Sweden)

    Boel Mörck

    2013-01-01

    Full Text Available The rationale of the study was to evaluate the efficacy of infliximab (IFX treatment in patients with ankylosing spondylitis (AS and to determine whether IFX dose reduction and interval extension sustains the treatment effect. Nineteen patients were included and treated with IFX 5 mg/kg every 6 weeks for 56 weeks. All patients concomitantly received MTX with median dose 7.5 mg/weekly. During the second year, the IFX dose was reduced to 3 mg/kg every 8 weeks. Eighteen patients completed the 1-year and 15 patients the 2-year trial. The ≥50% improvement at week 16 from baseline of BASDAI was achieved in 16/19 (84% patients. Significant reductions in BASDAI, BASFI, and BASMI scores, decrease in ESR and CRP, and improvement in SF-36 were observed at weeks 16 and 56. The MRI-defined inflammatory changes in the sacroiliac joints disappeared in 10/15 patients (67% already at 16 weeks. IFX treatment effect was sustained throughout the second year after IFX dose reduction and interval extension. We conclude that IFX treatment is effective in well-established active AS and a dose reduction sustains the treatment effect. These observations are of clinical importance and open the opportunity to reduce the drug costs. This trial is registered with ClinicalTrials.gov NCT01850121.

  19. Immunogenicity and safety of combined adsorbed low-dose diphtheria, tetanus and inactivated poliovirus vaccine (REVAXIS®) versus combined diphtheria, tetanus and inactivated poliovirus vaccine (DT Polio®) given as a booster dose at 6 years of age

    Science.gov (United States)

    Gajdos, Vincent; Soubeyrand, Benoit; Vidor, Emmanuel; Richard, Patrick; Boyer, Julie; Sadorge, Christine

    2011-01-01

    This randomized, comparative, phase-IIIb study conducted in France aimed to demonstrate whether seroprotection against diphtheria, tetanus and poliomyelitis 1 month after a single dose of REVAXIS (low-dose diphtheria) is non-inferior to seroprotection 1 month after a single dose of DT Polio (standard-dose diphtheria), both vaccines being given as a second booster to healthy children at 6 years of age. Children were randomly assigned to receive a single intramuscular dose of REVAXIS or DT Polio. Primary endpoints were the 1-month post-booster seroprotection rates for diphtheria, tetanus and poliovirus type-1, -2 and -3 antigens. Secondary endpoints were immunogenicity and safety observations. Of 788 children screened, 760 were randomized: REVAXIS group, 384 children; DT Polio group, 376 children. No relevant difference in demographic characteristics at baseline was observed between REVAXIS and DT Polio groups. Noninferiority of REVAXIS compared with DT Polio for seroprotection was demonstrated against diphtheria (respectively 98.6% and 99.3%), tetanus (respectively 99.6% and 100%) and poliovirus antigens (100% for each types in both groups). No allergic reactions to REVAXIS were reported. A benefit/risk ratio in favor of REVAXIS was suggested by the trend towards a better tolerability of REVAXIS compared with DT Polio regarding the rate of severe solicited injection-site reactions. The results support the use of REVAXIS as a booster at 6 years of age in infants who previously received a three-dose primary series within the first 6 months of life and a first booster including diphtheria, tetanus and poliovirus vaccine(s) given before 2 years of age. PMID:21441781

  20. Estimate of the genetically significant dose (GSD) in the Mexican population for the years 1996 and 1997

    International Nuclear Information System (INIS)

    Gama Trejo, G.; Alvarez Romero, J.T.

    2000-01-01

    An estimate of the GSD is presented for 1140 radiodiagnostic facilities from a survey carried out by the Ministry of Health in 1996, and 1368 facilities in 1997, corresponding to the 35 and 42% of the total of installations at Mexico respectively. The population in the interviews are divided in three age groups: from 0 to 15, from 16 to 40 and older than 40 years; and 14 different radiological studies are considered, classified by sex. The survey analysis shows that five examinations, that more contribute to the total are: thorax with 29% to 32%, extremities with 19.5% to 19.81%, head and neck with 11.1% to 11.2%, abdomen with 10.0% to 10.7%, and spinal column with 9.2%. The GSD is estimated in a minimum value of 15.4 and a maximum value of 601.9 μGy for the year 1996, and a minimum of 35.0 and a maximum of 1 199.5 μGy for 1997. Values that extrapolated to the total of the establishments correspond from a minimum of 44.0 and a maximum to 1 719.8 μGy for 1996; and 83.3 and 2 855.9 μGy for 1997. For the gonad doses Dg, we took the values of ICRP 34(1982) and UNSCEAR (1972, 1978). The expected number of children is obtained by specific fecundity for each age group in the year of 1996. The analysis of both surveys allows us to determine that: the average is of 923 studies for each thousand individuals, for 100% of the establishments in 1996, and 1 770 studies for each thousand in 1997. The minimum and maximum values of the GSD for Mexicans are 0.16 and 6.2 times in 1996 that the world average value, (that we calculate in 276.5 μGy); and 0.30 and 10.33 times for 1997. We conclude that it is very probable that our values of GSD are underestimated in both cases, because of: I. The estimate values of Dg are smaller to those measured and reported in the literature in other countries. II. It is necessary to optimize the classification of the groups of age of the surveyed people, (more than three groups) and the radiological studies (more than 14 studies) and III. It

  1. Five years' experience of occupational radiation dose reduction in positron emission tomography-computed tomography imaging at Prince Sultan Military Medical City

    International Nuclear Information System (INIS)

    Alenezi, Ahmed; Soliman, Khaled

    2016-01-01

    The number of installed PET/CT scanners is increasing leading to an increased workload which could result in higher radiation dose received by nuclear medicine workers responsible for conducting the imaging studies in clinical environment. An effort should be made to further optimize the current dose reduction methods employed to achieve 'as low as reasonably achievable' (ALARA) levels. The aim of this work is to provide an overview of the recent techniques used to reduce the occupational radiation doses in PET/CT practice. The worker radiation dose in PET/ CT is higher than in conventional nuclear medicine practice. The higher radiation dose is mainly from the high energy annihilation photons. The highest radiation exposures to the involved staff occur during the dispensing, injection of the Radiopharmaceuticals and performing direct communications with the injected patients at close range. During the period of five years of PET/CT practice at Prince Sultan military medical city (PSMMC) in Saudi Arabia, we have implemented several methods for staff dose optimization. The methods included the following: (1) Training and experience of PET/CT staff, (2) use of time of flight (TOF) technology, (3) optimized design and layout of the department, (4) use of lead shields and automatic dispensing/injection systems. The results from implementing the dose optimization methods are reflected on the staff occupational dose records by a reduction of 55% over a period of 5 years. The presented data can be applied to optimize radiation protection practices during PET/CT imaging procedures. (author)

  2. Effects of body habitus on internal radiation dose calculations using the 5-year-old anthropomorphic male models

    DEFF Research Database (Denmark)

    Xie, Tianwu; Kuster, Niels; Zaidi, Habib

    2017-01-01

    Xtended general purpose Monte Carlo transport code and calculated the absorbed dose and effective dose of five 18F-labelled radiotracers for children of various habitus. For most organs, the S-value of F-18 presents stronger statistical correlations with body weight, standing height and sitting height than BMI...... and SSR. The self-absorbed fraction and self-absorbed S-values of F-18 and the absorbed dose and effective dose of 18F-labelled radiotracers present with the strongest statistical correlations with body weight. For 18F-Amino acids, 18F-Brain receptor substances, 18F-FDG, 18F-L-DOPA and 18F-FBPA, the mean...... absolute effective dose differences between phantoms of different habitus and fixed reference models are 11.4%, 11.3%, 10.8%, 13.3% and 11.4%, respectively. Total body weight, standing height and sitting height have considerable effects on human internal dosimetry. Radiation dose calculations...

  3. MODELING THE VARIATIONS OF DOSE RATE MEASURED BY RAD DURING THE FIRST MSL MARTIAN YEAR: 2012–2014

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Jingnan; Wimmer-Schweingruber, Robert F.; Heber, Bernd; Köhler, Jan; Appel, Jan K.; Böhm, Eckart; Böttcher, Stephan; Burmeister, Sönke; Lohf, Henning; Martin, Cesar [Institute of Experimental and Applied Physics, Christian-Albrechts-University, Kiel (Germany); Zeitlin, Cary [Southwest Research Institute, Earth, Oceans and Space Department, Durham, NH (United States); Rafkin, Scot; Hassler, Donald M.; Ehresmann, Bent [Southwest Research Institute, Space Science and Engineering Division, Boulder, CO (United States); Posner, Arik [NASA Headquarters, Science Mission Directorate, Washington, DC (United States); Brinza, David E. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA (United States); Kahanpää, H. [Finnish Meteorological Institute, Helsinki (Finland); Reitz, Günther, E-mail: guo@physik.uni-kiel.de [Aerospace Medicine, Deutsches Zentrum für Luft- und Raumfahrt, Köln (Germany)

    2015-09-01

    The Radiation Assessment Detector (RAD), on board Mars Science Laboratory’s (MSL) rover Curiosity, measures the energy spectra of both energetic charged and neutral particles along with the radiation dose rate at the surface of Mars. With these first-ever measurements on the Martian surface, RAD observed several effects influencing the galactic cosmic-ray (GCR) induced surface radiation dose concurrently: (a) short-term diurnal variations of the Martian atmospheric pressure caused by daily thermal tides, (b) long-term seasonal pressure changes in the Martian atmosphere, and (c) the modulation of the primary GCR flux by the heliospheric magnetic field, which correlates with long-term solar activity and the rotation of the Sun. The RAD surface dose measurements, along with the surface pressure data and the solar modulation factor, are analyzed and fitted to empirical models that quantitatively demonstrate how the long-term influences ((b) and (c)) are related to the measured dose rates. Correspondingly, we can estimate dose rate and dose equivalents under different solar modulations and different atmospheric conditions, thus allowing empirical predictions of the Martian surface radiation environment.

  4. An analysis of uncertainty and of dependence on season of year of ingestion population dose arising from design basis accidents in advanced thermal reactors

    International Nuclear Information System (INIS)

    Nair, S.; Ponting, A.C.

    1985-03-01

    The results of a detailed study of ingestion collective dose from five limiting PWR design basis releases are presented, the PWR being chosen as being typical of an advanced thermal reactor for which source terms are readily available. The ingestion collective dose was calculated for a range of wind direction/weather scenarios for releases from a typical U.K. rural and a U.K. semi-urban site and scenarios identified where the ingestion pathway was of potential significance. The dependence of the ingestion collective dose for these cases on the season of year when the release occurs was investigated. An analysis was carried out of the uncertainty in the ''worst case'' ingestion calculations arising from uncertainties in foodchain input parameters. An efficient but comprehensive set of dynamic foodchain computer models was produced and the literature surveyed to produce probability distribution functions (PDF's) for all relevant independent input data items. These were used to produce output PDF's for food contamination levels and for ingestion collective dose from the five releases. Finally, the study has highlighted several areas central to ingestion collective dose assessments where the available data are inadequate. This led to the formulation of a set of future research requirements which will need to be met both to obtain a better fundamental understanding of foodchain transfer and to reduce uncertainties in ingestion collective dose assessments. (author)

  5. Screenings of lung cancer with low dose spiral CT: results of a three year pilot study and design of the randomised controlled trial Italung-CT

    International Nuclear Information System (INIS)

    Picozzi, Giulia; Paci, Enrico; Lopes Pegna, Andrea

    2005-01-01

    Purpose: To report the results of a three-year observational pilot study of lung cancer screening with low dose computed tomography (CT) and to present the study design of a randomised clinical trial named as Italung CT. Materials and methods: Sixty (47 males and 13 females, mean age 64±4.5 years) heavy smokers (at least 20 packs-year) underwent three low-dose spiral CT screening tests one year apart on a single slice or multislice CT scanner. Indeterminate nodules were managed according to the recommendations of the Early Lung Cancer Action Project. Results: Indeterminate nodules were observed in 33 (55%) of the subjects (60% at the baseline screening test, 24% at the first annual test and 16% at the second annual test). The size of the largest indeterminate nodule was [it

  6. Estimation of the collective ionizing dose in the Portuguese population for the years 2011 and 2012, due to nuclear medicine exams.

    Science.gov (United States)

    Costa, F; Teles, P; Nogueira, A; Barreto, A; Santos, A I; Carvalho, A; Martins, B; Oliveira, C; Gaspar, C; Barros, C; Neves, D; Costa, D; Rodrigues, E; Godinho, F; Alves, F; Cardoso, G; Cantinho, G; Conde, I; Vale, J; Santos, J; Isidoro, J; Pereira, J; Salgado, L; Rézio, M; Vieira, M; Simãozinho, P; Almeida, P; Castro, R; Parafita, R; Pintão, S; Lúcio, T; Reis, T; Vaz, P

    2015-01-01

    In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation doses for the Portuguese population. The current study is the continuation of this work, although it focuses only on NM exams for the years 2011 and 2012. The annual frequency of each of the 28 selected NM exams and the average administered activity per procedure was obtained by means of a nationwide survey sent to the 35 NM centres in Portugal. The results show a reduction of the number of cardiac exams performed in the last two years compared with 2010, leading to a reduction of the annual average effective dose of Portuguese population due to NM exams from 0.08 mSv ± 0.017 mSv/caput to 0.059 ± 0.011 mSv/caput in 2011 and 0.054 ± 0.011 mSv/caput in 2012. Portuguese total annual average collective effective dose due to medical procedures was estimated to be 625.6 ± 110.9 manSv in 2011 and 565.1 ± 117.3 manSv in 2012, a reduction in comparison with 2010 (840.3 ± 183.8 manSv). The most frequent exams and the ones that contributed the most for total population dose were the cardiac and bone exams, although a decrease observed in 2011 and in 2012 was verified. The authors intend to perform this study periodically to identify trends in the annual Portuguese average effective dose and to help to raise awareness about the potential dose optimization. Copyright © 2014 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

  7. Baseline status and dose to the penile bulb predict impotence 1 year after radiotherapy for prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cozzarini, Cesare; Badenchini, Fabio [San Raffaele Scientific Institute, Radiotherapy, Milano (Italy); Rancati, Tiziana [Fondazione IRCCS Istituto Nazionale dei Tumori, Prostate Cancer Program, Milan (Italy); Palorini, Federica; Improta, Ilaria; Fiorino, Claudio [San Raffaele Scientific Institute, Medical Physics, Milan (Italy); Avuzzi, Barbara [Fondazione IRCCS Istituto Nazionale dei Tumori, Radiation Oncology 1, Milan (Italy); Degli Esposti, Claudio [Ospedale Bellaria, Radiotherapy, Bologna (Italy); Girelli, Giuseppe [Ospedale ASL9, Radiotherapy, Ivrea (Italy); Vavassori, Vittorio [Cliniche Gavazzeni-Humanitas, Radiotherapy, Bergamo (Italy); Valdagni, Riccardo [Fondazione IRCCS Istituto Nazionale dei Tumori, Prostate Cancer Program, Milan (Italy); Fondazione IRCCS Istituto Nazionale dei Tumori, Radiation Oncology 1, Milan (Italy)

    2016-05-15

    To assess the predictors of the onset of impotence 1 year after radiotherapy for prostate cancer. In a multi-centric prospective study, the International Index of Erectile Function (IIEF) questionnaire-based potency of 91 hormone-naive and potent patients (IIEF1-5 > 11 before radiotherapy) was assessed. At the time of this analysis, information on potency 1 year after treatment was available for 62 of 91 patients (42 treated with hypofractionation: 2.35-2.65 Gy/fr, 70-74.2 Gy; 20 with conventional fractionation: 74-78 Gy). Prospectively collected individual information and D{sub max}/D{sub mean} to the penile bulb were available; the corresponding 2 Gy-equivalent values (EQD2 {sub max}/EQD2 {sub mean}) were also considered. Predictors of 1-year impotency were assessed through uni- and multi-variable backward logistic regression: The best cut-off values discriminating between potent and impotent patients were assessed by ROC analyses. The discriminative power of the models and goodness-of-fit were measured by AUC analysis and the Hosmer-Lemeshow (H and L) test. At 1-year follow-up, 26 of 62 patients (42 %) became impotent. The only predictive variables were baseline IIEF1-5 values (best cut-off baseline IIEF1-5 ≥ 19), D{sub max} ≥ 68.5 Gy and EQD2 {sub max} ≥ 74.2 Gy. The risk of 1-year impotence may be predicted by a two-variable model including baseline IIEF1-5 (OR: 0.80, p = 0.003) and EQD2 {sub max} ≥ 74.2 Gy (OR: 4.1, p = 0.022). The AUC of the model was 0.77 (95% CI: 0.64-0.87, p = 0.0007, H and L: p = 0.62). The 1-year risk of impotency after high-dose radiotherapy in potent men depends on the EQD2 {sub max} to the penile bulb and on baseline IIEF1-5 values. A significant reduction in the risk may be expected mainly when sparing the bulb in patients with no/mild baseline impotency (IIEF1-5 > 17). (orig.) [German] Beurteilung von Praediktoren fuer das Auftreten von Impotenz 1 Jahr nach Radiotherapie bei Prostatakrebs. In einer multizentrischen

  8. High and low doses of antimony (Sb v in American cutaneous leishmaniasis: a five years follow-up study of 15 patients

    Directory of Open Access Journals (Sweden)

    MP Oliveira-Neto

    1996-04-01

    Full Text Available Seventeen patients proceeding from the municipality of Rio de Janeiro, Brazil presenting with the cutaneous ulcerative form of American leishmaniasis were treated with one ampoule of pentavalent antimony daily for 30 days. With this regimen the individuals doses varies greatly: from 3.8 mg/kg of body weight to 22.3 mg/kg. After five years, patients receiving either a smaller dose or a bigger one, showed the same therapeutic result: cutaneous scars and no mucosal lesions.

  9. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults >= 60 years of age

    NARCIS (Netherlands)

    Vermeulen, Joost N.; Lange, Joep M. A.; Tyring, Stephen K.; Peters, Patrick H.; Nunez, Margaret; Poland, Gregory; Levin, Myron J.; Freeman, Carrie; Chalikonda, Ira; Li, Jianjun; Smith, Jeffrey G.; Caulfield, Michael J.; Stek, Jon E.; Chan, Ivan S. F.; Vessey, Rupert; Schödel, Florian P.; Annunziato, Paula W.; Schlienger, Katia; Silber, Jeffrey L.

    2012-01-01

    Background: Incidence and severity of herpes zoster (HZ) and postherpetic neuralgia increase with age, associated with age-related decrease in immunity to varicella-zoster virus (VZV). One dose of zoster vaccine (ZV) has demonstrated substantial protection against HZ; this study examined impact of a

  10. The response of coffee trees to doses of boron soil applications two or three times a year in Andisoles at Heredia, Costa Rica

    International Nuclear Information System (INIS)

    Ramirez, J. E.

    1999-01-01

    The response of coffee trees to doses of Boron soil applications two or three times a year in Andisoles at Heredia, Costa Rica. The effect of coffee production of increasing boron doses, applied to the soil two or three times a year, was tested in a 4 year-old plantation cv. Caturra, growing in a Typic Haplustand at Heredia, Costa Rica, from 1991 to 1994. The effect of B contents in soil and leaves (2nd or 4th pair), the Ca/B ratios, and toxicity symptoms, were also determined. There were significant differences among treatments in all variables. The highest yields were obtained with 40 kg/ha B 2 O 3 split into three applications: May, August and November (early, mid and late rainy season). Yields of four annual harvest periods decreased significantly as doses increased over 40 kg/ha. Increasing B doses shifted Ca/B foliar ratios toward values reported as toxic, and more so in the 4th leaf pair. All treatments except 20 Kg/ha B 2 O 3 induced slight to severe toxicity symptoms on leaves. (Author) [es

  11. Muscular variations during axillary dissection: A clinical study in fifty patients

    Directory of Open Access Journals (Sweden)

    Upasna

    2015-01-01

    Methods: The anatomy of axilla regarding muscular variations was studied in 50 patients who had an axillary dissection for the staging and treatment of invasive primary breast cancer over one year. Results: In a period of one year, two patients (4% with axillary arch and one patient (2% with absent pectoralis major and minor muscles among fifty patients undergoing axillary surgery for breast cancer were identified. Conclusions: Axillary arch when present should always be identified and formally divided to allow adequate exposure of axillary contents, in order to achieve a complete lymphatic dissection. Complete absence of pectoralis major and minor muscles precludes the insertion of breast implants and worsens the prognosis of breast cancer.

  12. The nuclear medical diagnostic procedures at the hospitals in Sofia over a period of ten years - from 1990 to 2000 - structure, number and doses

    International Nuclear Information System (INIS)

    Adelina, P.; Ingilizova, K.; Paskalev, Z

    2003-01-01

    The aim of this study is to analyze the structure and the number of nuclear diagnostic procedures at hospitals in Sofia over a period of ten years (from 1990 to 2000); to calculate the effective doses received by patients; to compare the results from different hospitals. We have developed a form in order to collect the necessary information from hospitals (nuclear laboratories). The information has been collected according to examined organ, applied radioactive pharmaceutical and injected activity (MBq), patient's age and sex. The effective doses have been calculated using transition coefficients for each of the applied radioactive pharmaceuticals and for each of the diagnostic procedures. We have received the information and calculated the doses. We have compared the data from different hospitals (nuclear laboratories). The results show that the doctors in different hospitals have used different radioactive pharmaceuticals and applied different activities for one and the same procedure. (orig.)

  13. Immunogenicity and safety of one dose of diphtheria, tetanus, acellular pertussis and poliomyelitis vaccine (Repevax®) followed by two doses of diphtheria, tetanus and poliomyelitis vaccine (Revaxis®) in adults aged ≥ 40 years not receiving a diphtheria- and tetanus-containing vaccination in the last 20 years.

    Science.gov (United States)

    Dominicus, Rolf; Galtier, Florence; Richard, Patrick; Baudin, Martine

    2014-06-30

    The immunogenicity and safety of one dose of Tdap-IPV (tetanus, diphtheria, acellular pertussis and inactivated poliomyelitis vaccine) and two doses of Td-IPV (tetanus, diphtheria and inactivated poliomyelitis vaccine) were assessed in adults who had not received a diphtheria- and tetanus-containing vaccine in the last 20 years. This open-label, multicentre study was conducted in adults aged ≥ 40 years with no diphtheria- and tetanus-containing vaccine in the last 20 years. Participants received one dose of Tdap-IPV followed by two doses of Td-IPV (0, 1, 6 month schedule). Primary immunogenicity objectives: to demonstrate acceptable seroprotection rates (percentage of participants with antibody titre above threshold) post-dose 3 for diphtheria (≥ 0.1IU/mL by seroneutralization assay [SNA]); tetanus (≥ 0.1IU/mL by enzyme-linked immunosorbent assay [ELISA]); and poliomyelitis (≥ 8 1/dil by SNA); and to evaluate the percentage of participants with an antibody concentration ≥ 5EU/mL (by ELISA) for pertussis antigens post-dose 1. Seroprotection rates were acceptable if the lower limit of the 95% confidence interval (CI) was >95%. Percentage of participants with basic clinical immunity against diphtheria (≥ 0.01IU/mL) was also assessed. Safety (adverse events [AEs] and serious AEs) was assessed after each dose. Overall, 336 participants were included (mean age: 60.2 years). Post-dose 3 seroprotection rates were: diphtheria, 94.6% (CI 91.5-96.8); tetanus and poliomyelitis, 100% (CI: 98.8-100). Percentage of participants with an antibody titre ≥ 5EU/mL against pertussis antigens was ≥ 95.8% for all five pertussis components. Basic clinical immunity against diphtheria was achieved in 100% (CI: 98.8-100) of participants. AEs were reported more frequently following vaccination with Tdap-IPV (post-dose 1: 65.3%) than with Td-IPV (post-dose 2: 48.3%; post-dose 3: 50.3%). This study highlights the benefits of using Tdap-IPV followed by two doses of Td-IPV in an

  14. Comparison of immune persistence among inactivated and live attenuated hepatitis a vaccines 2 years after a single dose

    Science.gov (United States)

    Zhang, Xiaoshu; An, Jing; Tu, Aixia; Liang, Xuefeng; Cui, Fuqiang; Zheng, Hui; Tang, Yu; Liu, Jianfeng; Wang, Xuxia; Zhang, Ningjing; Li, Hui

    2016-01-01

    ABSTRACT Objective: Compare immune persistence from one dose of each of 3 different hepatitis A vaccines when given to school-age children: a domestic, live attenuated hepatitis A vaccine (H2 vaccine); a domestic inactivated hepatitis A vaccine (Healive®); and an imported, inactivated hepatitis A vaccine (Havrix®),.Methods: School-age children were randomized into 1 of 4 groups to receive a single dose of a vaccine: H2 vaccine, Healive®, Havrix®, or hepatitis B vaccine [control]. Serum samples were collected 12 and 24 months after vaccination for measurement of anti-HAV IgG using microparticle enzyme immunoassay. Seropositivity was defined as ≥ 20 mUI/ml. We compared groups on seropositivity and geometric mean concentration (GMC). Results: Seropositive rates for the H2, Healive®, Havrix®, and control groups were 64%, 94.4%, 73%, and 1.0%, respectively, 12-months post-vaccination; and 63%, 95.6%, 72%, and 1.0%, respectively 24-months post-vaccination. Seropositivity was greater for Healive® than for H2 and Havrix® at 12 months (p-values a single dose of inactivated hepatitis A vaccine and live attenuated hepatitis A vaccine. PMID:27494260

  15. Dose-Response Relationship between Cumulative Occupational Lead Exposure and the Associated Health Damages: A 20-Year Cohort Study of a Smelter in China.

    Science.gov (United States)

    Wu, Yue; Gu, Jun-Ming; Huang, Yun; Duan, Yan-Ying; Huang, Rui-Xue; Hu, Jian-An

    2016-03-16

    Long-term airborne lead exposure, even below official occupational limits, has been found to cause lead poisoning at higher frequencies than expected, which suggests that China's existing occupational exposure limits should be reexamined. A retrospective cohort study was conducted on 1832 smelting workers from 1988 to 2008 in China. These were individuals who entered the plant and came into continuous contact with lead at work for longer than 3 months. The dose-response relationship between occupational cumulative lead exposure and lead poisoning, abnormal blood lead, urinary lead and erythrocyte zinc protoporphyrin (ZPP) were analyzed and the benchmark dose lower bound confidence limits (BMDLs) were calculated. Statistically significant positive correlations were found between cumulative lead dust and lead fumes exposures and workplace seniority, blood lead, urinary lead and ZPP values. A dose-response relationship was observed between cumulative lead dust or lead fumes exposure and lead poisoning (p lead dust and fumes doses were 0.68 mg-year/m³ and 0.30 mg-year/m³ for lead poisoning, respectively. The BMDLs of workplace airborne lead concentrations associated with lead poisoning were 0.02 mg/m³ and 0.01 mg/m³ for occupational exposure lead dust and lead fume, respectively. In conclusion, BMDLs for airborne lead were lower than occupational exposure limits, suggesting that the occupational lead exposure limits need re-examination and adjustment. Occupational cumulative exposure limits (OCELs) should be established to better prevent occupational lead poisoning.

  16. Our experience of high dose I-131 therapy in 75 patients with well differentiated carcinoma thyroid followed up over 5 years

    International Nuclear Information System (INIS)

    Dougall, P.; Kumar, A.; Ashok, P.; Chinwan, B.P.; Khan, B.; Pandey, D.; Joshi, N.D.

    2005-01-01

    Thyroid cancer is the most common endocrine malignancy. The epidemiology of thyroid cancer is variable, depending on the geographic location of the patient population. Well differentiated thyroid cancer (WTC), is responsive to high dose I-131 treatment, and is the most accepted form of therapy, even though the dose administered for ablation of residual thyroid tissue maybe controversial. At our centre, 75 patients of WTC, mean age 42.4 years, 22 males and 53 females (M:F 1:2.4), were treated with high dose oral I-131 therapy with a Total Mean Dose (TMD) of 263.6 mCi, 4 - 6 weeks post thyroidectomy. They were followed up over a period of 6 years. Twenty ( 26.7%) patients had follicular cancer (FC), 47 (62.7%) papillary cancer (PC) and 8 (10.7%) were mixed (MC), on histopathology, at presentation. 38 (50.7%) patients had only residual thyroid tissue (RTT) on I-131 whole body bone scan (WBS) and 37 (49.3%) presented with metastatic disease (MD) at the time of therapy. Of the 37 patients with MD, 21 (56.8%) had metastases to the lymph nodes, 6 (16.2%) to the lungs, 4 (10.8%) to bone, 3 (8.1%) to bone and lung, and 4 (10.8%) to lung plus lymph nodes. Twenty-three patients (7 FC , 13 - PC and 3 MC; 6 RTT, 17 - MD) , received more than one dose of I-131 with a TMD of 422.7 mCi (Range 88 1590 mCi ). 52 patients (13 FC, 34 PC, 5 MC; 20 MD and 32 RTT) received a single TMD of 104.4 (Range 39.5 219 mCi). On follow-up, 3 patients of FC with MD (2 lung metastasis and 1 with extensive lymph node metastasis), died within 3 months 2 years of therapy. 3 patients of MD (2 FC, 1-MC; 2 bone metastasis and 1 bone with lung metastasis) died after 5 .5 years, Of the 6 patients who died, 5 were FC and only 1 was MC. 2 patients with MD to lungs and bone had received a single dose and were lost to follow up. All patients with PC and FC with only RTT, were surviving at the end of 5 years. None of the patients with MD to lymph nodes died at the end of 5 years, either receiving single or

  17. Selection and Classification of United States Military Officers: A fifty-Year Bibliography (1937-1986)

    Science.gov (United States)

    1989-03-01

    orientation in Naval aviation cadets. Journal of Educational Psychology , 45, 91-109. 908 Creelman , J.A. (1954). An analysis of the physical fitness index...International Index to Periodicals. (e) Military Testing Association Proceedings, and (f) Psychological Abstracts. The research organizations of the armed...Texas, can trace its beginning to a number of Psychological Research Units of the Medical Division of the United States Army Air Corps. Some of the

  18. Fifty Years since the Coleman Report: Rethinking the Relationship between Schools and Inequality

    Science.gov (United States)

    Downey, Douglas B.; Condron, Dennis J.

    2016-01-01

    In the half century since the 1966 Coleman Report, scholars have yet to develop a consensus regarding the relationship between schools and inequality. The Coleman Report suggested that schools play little role in generating achievement gaps, but social scientists have identified many ways in which schools provide better learning environments to…

  19. Fifty years contribution to research and technological development of Argentina. Part 7

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2004-01-01

    The paper is the seventh part of a short history of the National Atomic Energy Commission (CNEA). The future of the nuclear activities in the country is outlined, mainly of those related to the energy generation. The completion of the Atucha II nuclear power plant now under construction is supported. (author)

  20. Fifty years contribution to research and technological development of Argentina. Part 4

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2003-01-01

    The paper is the forth part of a short history of the National Atomic Energy Commission (CNEA). The activities concerning the radioactive waste management are reviewed as well as the research and development programs in the sciences related to nuclear energy. (author)

  1. Fifty years contribution to research and technological development of Argentina. Part 1

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2001-01-01

    The paper is the first part of a short history of the Argentine National Atomic Energy Commission (CNEA). The activities concerning the fuel cycle are reviewed. The uranium production as well as the manufacturing of nuclear fuel elements is described. (author)

  2. Fifty years contribution to research and technological development of Argentina. Part 3

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2001-01-01

    This paper is the third part of a short history of the National Atomic Energy Commission (CNEA). The activities concerning the radioisotope and radiation applications are reviewed as well as the radiation protection program

  3. Fifty years contribution to research and technological development of Argentina. Part 6

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2004-01-01

    The paper is the sixth part of a short history of the National Atomic Energy Commission (CNEA). The international relations and the nuclear technology exports of the CNEA are reviewed. A short description of the Argentine nuclear centers and nuclear enterprises is also given. The present structure of the CNEA is briefly outlined. (author)

  4. Fifty years contribution to research and technological development of Argentina. Part 5

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2003-01-01

    The paper is the fifth part of a short history of the National Atomic Energy Commission (CNEA). The activities concerning the development of the institutional infrastructure and the education and training activities are reviewed as well as the legal and regulatory aspects of nuclear energy in Argentina. (author)

  5. Fifty years contribution to research and technological development of Argentina. Part 2

    International Nuclear Information System (INIS)

    Aguirre, Fernando; Boselli, Alfredo; Colangelo, Luis J.; Coll, Jorge A.; Espejo, Hector; Mattei, Clara E.; Ornstein, Roberto M.; Palacios, Tulio A.; Radicella, Renato; Rodrigo, Felix

    2002-01-01

    The paper is the second part of a short history of the Argentine National Atomic Energy Commission (CNEA). The activities concerning research reactors are reviewed as well as the nuclear power program. The heavy water program is also is described. (author)

  6. Reforecasting the ENSO Events in the Past Fifty-Seven Years (1958-2014)

    Science.gov (United States)

    Huang, B.; Shin, C. S.; Shukla, J.; Marx, L.; Balmaseda, M.; Halder, S.; Dirmeyer, P.; Kinter, J. L.

    2016-12-01

    A set of ensemble seasonal reforecasts for 1958-2014 is conducted using the National Centers for Environmental Prediction (NCEP) Climate Forecast System, version 2 (CFSv2), initialized with observation-based ocean, atmosphere, land and sea ice reanalyses, including the Eu­ropean Centre for Medium-Range Weather Forecasts (ECMWF) global ocean reanalysis version 4, the ERA-40 atmospheric reanalysis, the NCEP CFS Reanalysis for atmosphere, land and sea ice, and the NASA Global Land Data Assimilation System reanalysis version 2.0 for land. The purpose is to examine a long and continuous seasonal reforecast dataset from a modern seasonal forecast system to be used by the research community. In comparison with other current reforecasts, this dataset allows us to evaluate the degree to which El Niño and Southern Oscillation (ENSO) events can be predicted, using a larger sample of events. Furthermore, we can directly compare the predictability of the ENSO events in 1960s-70s with the more widely studied ENSO events occurring since the 1980s to examine the state-of-the-art seasonal forecast system's capability at different phases of global climate change and multidecadal variability. A major concern is whether the seasonal reforecasts before 1979 have useful skill when there were fewer ocean observations. Our preliminary examination of the reforecasts shows that, although the reforecasts have lower skill in predicting the SST anomalies in the North Pacific and North Atlantic before 1979, the prediction skill of the ENSO onset and development for 1958-1978 is comparable to that for 1979-2014. The skill of the earlier predictions declines faster in the ENSO decaying phase because the reforecasts initialized after the summer season persistently predict lingering wind and SST anomalies in the eastern equatorial Pacific during the decaying phase of several major ENSO events in the 1960s-70s. Since the 1980s, the reforecasts initialized in fall overestimate the peak SST anomalies in strong El Niño events. Both facts imply that the model air-sea feedback is overly active in the eastern Pacific before ENSO termination, likely induced by the model warm bias in the eastern Pacific during boreal winter and spring.

  7. [National Academy of Medicine, one hundred and fifty-four academic year].

    Science.gov (United States)

    Mansilla-Olivares, Armando

    2017-01-01

    El incalculable valor que atesora la Academia Nacional de Medicina, su enorme influencia y repercusión sobre la toma de decisiones médico-científico-epidemiológicas, radica única y exclusivamente en el dominio del conocimiento, la mente científica y el talento de todos y cada uno de sus miembros, desde su fundación en 1864 hasta nuestros días.

  8. Fifty years of discovery of alpha-fetoprotein as the first tumor marker

    Directory of Open Access Journals (Sweden)

    Nikulina Dina

    2015-01-01

    Full Text Available Alpha-fetoprotein represents the most prominent oncobiomarker, widely used in the diagnosis of hepatocellular carcinoma for monitoring of tumor progression, presence of metastasis, assessment of cancer prognosis and successful antitumor therapeutic measures. Yuri Semenovich Tatarinov is a Russian scientist who first published antigen specific for human hepatocellular carcinoma in 1963. To commemorate the 50th anniversary of the discovery of alpha-fetoprotein, 9th International Scientific- Practical Conference entitled “Achievements of fundamental science and translational medicine capabilities in solving actual problems of practical public health”, was held from May 6-8th, 2013 in Astrakhan, Russia. The conference was held in memory of historical scientific work of Yuri Semenovich Tatarinov. [Projekat Ministarstva nauke Republike Srbije, br. 175056

  9. FIFTY YEARS OF YANG-MILLS THEORIES: A Phenomenological Point of View

    Science.gov (United States)

    de Rújula, Alvaro

    On the occasion of the celebration of the first half-century of Yang-Mills theories, I am contributing a personal recollection of how the subject, in its early times, confronted physical reality, that is, its "phenomenology". There is nothing original in this work, except, perhaps, my own points of view. But I hope that the older practitioners of the field will find here grounds form nostalgia, or good reasons to disagree with me. Younger addicts may learn that history does not resemble at all what is reflected in current textbooks: it was orders of magnitude more fascinating.

  10. How Development Assistance from France and the United Kingdom Has Evolved: Fifty Years on from Decolonisation

    Directory of Open Access Journals (Sweden)

    François Pacquement

    2010-03-01

    Full Text Available France and the United Kingdom are influential backers when it comes to the global governance of aid to developing countries. A short history of the contributions made by these former colonial powers to ODA is presented, covering the institutions concerned, strategies conducted and funding provided. These institutions have undergone complex changes since the initial phase of making “improvements” in the colonies up until recent reforms. Their ambitious strategies, grounded on considerable research, have received attention from a multilateral audience, turning the colonial question into a global issue. The vision of aid in both France and the UK is broader than is conveyed by the calculations that are carried out by the OECD’s DAC. Though subject to political contingencies, aid from these countries amounts to a substantial contribution that seeks to respond to various development needs.

  11. Fifty years working to improve food and nutrition in Central America

    Directory of Open Access Journals (Sweden)

    1999-12-01

    Full Text Available El Instituto de Nutrición de Centroamérica y Panamá (INCAP, un centro especializado de la Organización Panamericana de la Salud con sede en la ciudad de Guatemala (Guatemala, cumple este año medio siglo de trabajo dedicado a mejorar la alimentación y nutrición en Centroamérica. El Instituto ha conseguido importantes logros en diferentes áreas, que incluyen la investigación, la cooperación técnica, la formación y la diseminación de información científica y técnica.

  12. Fifty Years of Research in ARDS. Respiratory Mechanics in Acute Respiratory Distress Syndrome.

    Science.gov (United States)

    Henderson, William R; Chen, Lu; Amato, Marcelo B P; Brochard, Laurent J

    2017-10-01

    Acute respiratory distress syndrome is a multifactorial lung injury that continues to be associated with high levels of morbidity and mortality. Mechanical ventilation, although lifesaving, is associated with new iatrogenic injury. Current best practice involves the use of small Vt, low plateau and driving pressures, and high levels of positive end-expiratory pressure. Collectively, these interventions are termed "lung-protective ventilation." Recent investigations suggest that individualized measurements of pulmonary mechanical variables rather than population-based ventilation prescriptions may be used to set the ventilator with the potential to improve outcomes beyond those achieved with standard lung protective ventilation. This review outlines the measurement and application of clinically applicable pulmonary mechanical concepts, such as plateau pressures, driving pressure, transpulmonary pressures, stress index, and measurement of strain. In addition, the concept of the "baby lung" and the utility of dynamic in addition to static measures of pulmonary mechanical variables are discussed.

  13. The jewel on the mountaintop the European Southern Observatory through fifty years

    CERN Document Server

    Madsen, Claus

    2013-01-01

    Authored by ESO senior advisor Claus Madsen, the present book comprises 576 action-packed pages of ESO history and dramatic stories about the people behind the organisation. This is the ultimate historical account about ESO and its telescopes in the southern hemisphere, but also about a truly remarkable European success story in research. Spanning the range from the first telescopes to the future platforms of the next generation, it shows how the improvement of the telescopes leads to a continuously changing view of the Universe. With 150 photos and illustrations. Produced especially for ESO's

  14. The Armed Forces Epidemiological Board: Its First Fifty Years, 1940-1990

    Science.gov (United States)

    1990-02-01

    measles; (9 mumps; (g) diphtheria and tetanus toxoids; (I) enteric infections such as bacillary dysentery, Shigella, Sahnonella typhosa, Vibrio cholerae ...pestis that followed the kissing of the dead. Once he remarked that a patient in New Mexico did not die of plague but of "too many antibiotics." Another...interests shifted to hog cholera and the f’eld of virology. This interest continued for the next thirty-eight y’ears. A key obs,’.%ation (with Dr. Paul

  15. International Nuclear Societies Council vision for the second fifty years of nuclear energy

    International Nuclear Information System (INIS)

    Hatcher, S.R.

    1994-01-01

    A vision of the future is presented in the context of ongoing social and technological development. The most compelling moral and ethical issue facing the world at the close of the 20th Century is to help the peoples of the poorer countries in their struggle for a reasonable quality of life, while at the same time they face a dramatic increase in their population. The new society will need vastly more energy than the world of today. It will need all supply options that can provide the energy in an economic environmentally sustainable manner. Nuclear energy will be a vital element in this supply pattern, provided that it continues to demonstrate the imperatives of safe operation and economic competitiveness. Other applications of nuclear energy will add their own impact to the improving quality of life. 5 refs., 1 fig

  16. Perspective: Fifty years of density-functional theory in chemical physics

    Energy Technology Data Exchange (ETDEWEB)

    Becke, Axel D., E-mail: axel.becke@dal.ca [Department of Chemistry, Dalhousie University, 6274 Coburg Rd., P.O. Box 15000, Halifax, Nova Scotia B3H 4R2 (Canada)

    2014-05-14

    Since its formal inception in 1964–1965, Kohn-Sham density-functional theory (KS-DFT) has become the most popular electronic structure method in computational physics and chemistry. Its popularity stems from its beautifully simple conceptual framework and computational elegance. The rise of KS-DFT in chemical physics began in earnest in the mid 1980s, when crucial developments in its exchange-correlation term gave the theory predictive power competitive with well-developed wave-function methods. Today KS-DFT finds itself under increasing pressure to deliver higher and higher accuracy and to adapt to ever more challenging problems. If we are not mindful, however, these pressures may submerge the theory in the wave-function sea. KS-DFT might be lost. I am hopeful the Kohn-Sham philosophical, theoretical, and computational framework can be preserved. This Perspective outlines the history, basic concepts, and present status of KS-DFT in chemical physics, and offers suggestions for its future development.

  17. Pasolini fifty years ago: «Mi è tornata la fantasia del narratore»

    Directory of Open Access Journals (Sweden)

    Alfredo Barberis

    2014-05-01

    Full Text Available An interview with Pier Paolo Pasolini by Alfredo Barberi, published by «il Giorno» in 1964 and since then only republished once in a now exrtemely rare collection by Oronzo Panageli.

  18. IAEA fifty years: more than just safeguards. Interview with Professor Werner Burkart

    International Nuclear Information System (INIS)

    Anon.

    2007-01-01

    Professor Werner Burkart, IAEA Deputy Director General and head of the Nuclear Sciences and Applications Division, comments upon matters associated with the fiftieth anniversary of the International Atomic Energy Agency (IAEA). The Agency was founded on July 29, 1957. Today it is a worldwide organization of the United Nations with 144 member countries and manifold duties in the field of nuclear power utilization. The mandate of IAEA is based on the 'Atoms for Peace' initiative, its essence being support of all member countries in the use of nuclear power as long as IAEA safeguards on the spot ensure that no military aims are pursued in those activities. The safeguards work serves to prevent military uses. IAEA recommendations for a global nuclear safety culture, the so-called Safety Standards, are employed by member countries as a basis of legislation and ordinances. The emerging renaissance of nuclear power will be accompanied by the IAEA especially with regard to the important aspects of harmonization, safeguards, safety, security, and readiness for emergencies. The interview took place in Vienna on September 20, 2007. The questions were asked by the President of the Swiss Nuclear Forum, Dr. Bruno Pellaud, former Deputy Director General of IAEA. (orig.)

  19. Perspective: Fifty years of density-functional theory in chemical physics

    International Nuclear Information System (INIS)

    Becke, Axel D.

    2014-01-01

    Since its formal inception in 1964–1965, Kohn-Sham density-functional theory (KS-DFT) has become the most popular electronic structure method in computational physics and chemistry. Its popularity stems from its beautifully simple conceptual framework and computational elegance. The rise of KS-DFT in chemical physics began in earnest in the mid 1980s, when crucial developments in its exchange-correlation term gave the theory predictive power competitive with well-developed wave-function methods. Today KS-DFT finds itself under increasing pressure to deliver higher and higher accuracy and to adapt to ever more challenging problems. If we are not mindful, however, these pressures may submerge the theory in the wave-function sea. KS-DFT might be lost. I am hopeful the Kohn-Sham philosophical, theoretical, and computational framework can be preserved. This Perspective outlines the history, basic concepts, and present status of KS-DFT in chemical physics, and offers suggestions for its future development

  20. CASTLE BRAVO: Fifty Years of Legend and Lore. A Guide to Off-Site Radiation Exposures

    Science.gov (United States)

    2013-01-31

    depressions , may grow rapidly from small beginnings—from small perturbations in a broad, unstable air stream—has led to the suggestion that the...Hygiene and Toxicology 25(7)253–274. ——. 1974. Paper presented in Radiology Centennial . Radiology Centennial , Inc., Reston, VA. Fehner, T. R., and F. G

  1. History of initial fifty years of ARIES: A Major National Indian Facility for Optical Observations

    Science.gov (United States)

    Sanwal, Basant Ballabh; Pandey, Anil Kumar; Uddin, Wahab; Kumar, Brijesh; Joshi, Santosh

    2018-04-01

    The idea of starting an astronomical observatory in the state of Uttar Pradesh in India germinated through the initiative of a scholarly statesman Babu Sampurnanandji. His interest in astrology coupled with his academic bent of mind got him interested in modern astronomy. Being then Education Minister and later Chief Minister of Uttar Pradesh, he established an astronomical observatory at Varanasi on April 20, 1954. Later on it was shifted to Manora Peak, Nainital. Four reflectors were commissioned at Manora Peak. For solar research an H alpha petrol unit and a horizontal solar spectrograph was setup. A detailed project report for installation of a 4-m class optical telescope was prepared indigenously in late 1980, however, the project could not take off. With the generous support of the Department of Science and Technology, the institute established a 3.6-m new technology optical telescope and a 1.3-m wide field optical telescope at a new observing site called Devasthal. Now a 4-m liquid mirror telescope is also being installed at the same observing site. I present here a brief journey of the observatory beginning right from its birth in 1954 till now.

  2. Fifty years of chasing lizards: new insights advance optimal escape theory.

    Science.gov (United States)

    Samia, Diogo S M; Blumstein, Daniel T; Stankowich, Theodore; Cooper, William E

    2016-05-01

    Systematic reviews and meta-analyses often examine data from diverse taxa to identify general patterns of effect sizes. Meta-analyses that focus on identifying generalisations in a single taxon are also valuable because species in a taxon are more likely to share similar unique constraints. We conducted a comprehensive phylogenetic meta-analysis of flight initiation distance in lizards. Flight initiation distance (FID) is a common metric used to quantify risk-taking and has previously been shown to reflect adaptive decision-making. The past decade has seen an explosion of studies focused on quantifying FID in lizards, and, because lizards occur in a wide range of habitats, are ecologically diverse, and are typically smaller and differ physiologically from the better studied mammals and birds, they are worthy of detailed examination. We found that variables that reflect the costs or benefits of flight (being engaged in social interactions, having food available) as well as certain predator effects (predator size and approach speed) had large effects on FID in the directions predicted by optimal escape theory. Variables that were associated with morphology (with the exception of crypsis) and physiology had relatively small effects, whereas habitat selection factors typically had moderate to large effect sizes. Lizards, like other taxa, are very sensitive to the costs of flight. © 2015 Cambridge Philosophical Society.

  3. Fifty Interesting Years: Higher Education Funding and Financial Management 1961-2011

    Science.gov (United States)

    Williams, Gareth

    2012-01-01

    During the half century of the AUA's existence UK universities have experienced the fastest rate of growth and most far-reaching changes in their history. Funding arrangements in particular have changed radically. Since 1961 the finance office has been transformed from a small group of bean counters into a key management group at the heart of all…

  4. An Appreciation of Clinton B. Ford and the AAVSO of Fifty Years Ago

    Science.gov (United States)

    Hull, T.

    2012-06-01

    This is a rather personal story about Clinton B. Ford, my boyhood mentor in astronomy, and about the influence of the AAVSO and Clint on my life and career. While much has been written on Clint, this addresses the man, and his kindness. Naturally I joined the AAVSO (a little early, I was fifteen) and attended the AAVSO 50th Annual Meeting at Harvard College Observatory. Remembrance of Clint and the 50th Annual Meeting is given.

  5. Educating the Educators: A Fifty-Year Retrospective of Religious Education in the Catholic Context

    Science.gov (United States)

    Gilmour, Peter

    2015-01-01

    The progressive spirit of the Second Vatican Council (1962-1965) spawned a myriad of graduate departments of religious education in American Catholic colleges and universities. These departments evolved to include other master degrees (e.g., pastoral studies, pastoral counseling, divinity, spirituality, and social justice). As the numbers of…

  6. The Premise of Black Inferiority: An Enduring Obstacle Fifty Years Post-"Brown"

    Science.gov (United States)

    O'Connor, Carla

    2006-01-01

    Gloria Ladson-Billings explains in her chapter that, in part, the promise of "Brown v. Board of Education" has not been realized because it was premised on black inferiority. She elaborates that "instead of addressing the underlying pathology of the defendant--White supremacy"--the evidence, case, and accordant ruling…

  7. Fifty-thousand-year vegetation and climate history of Noel Kempff Mercado National Park, Bolivian Amazon

    Science.gov (United States)

    Burbridge, Rachel E.; Mayle, Francis E.; Killeen, Timothy J.

    2004-03-01

    Pollen and charcoal records from two large, shallow lakes reveal that throughout most of the past 50,000 yr Noel Kempff Mercado National Park, in northeastern lowland Bolivia (southwestern Amazon Basin), was predominantly covered by savannas and seasonally dry semideciduous forests. Lowered atmospheric CO 2 concentrations, in combination with a longer dry season, caused expansion of dry forests and savannas during the last glacial period, especially at the last glacial maximum. These ecosystems persisted until the mid-Holocene, although they underwent significant species reassortment. Forest communities containing a mixture of evergreen and semideciduous species began to expand between 6000 and 3000 14C yr B.P. Humid evergreen rain forests expanded to cover most of the area within the past 2000 14C yr B.P., coincident with a reduction in fire frequencies. Comparisons between modern pollen spectra and vegetation reveal that the Moraceae-dominated rain forest pollen spectra likely have a regional source area at least 2-3 km beyond the lake shore, whereas the grass- and sedge-dominated savanna pollen spectra likely have a predominantly local source area. The Holocene vegetation changes are consistent with independent paleoprecipitation records from the Bolivian Altiplano and paleovegetation records from other parts of southwestern Amazonia. The progressive expansion in rain forests through the Holocene can be largely attributed to enhanced convective activity over Amazonia, due to greater seasonality of insolation in the Southern Hemisphere tropics driven by the precession cycle according to the Milankovitch Astronomical Theory.

  8. Fifty Years of Quasars From Early Observations and Ideas to Future Research

    CERN Document Server

    Marziani, Paola; Sulentic, Jack

    2012-01-01

    The 50th anniversary of the discovery of quasars in 1963 presents an interesting opportunity to ask questions about the current state of quasar research. Formatted as a series of interviews with noted researchers in the field, each of them asked to address a specific set of questions covering topics selected by the editors, this book deals with the historical development of quasar research and discusses how advances in instrumentation and computational capabilities have benefitted quasar astronomy and have changed our basic understanding of quasars. In the last part of the book the interviews address the current topic of the role of quasars in galaxy evolution. They summarise open issues in understanding active galactic nuclei and quasars and present an outlook regarding what future observational facilities both on the ground and in space might reveal. Its interview format, the fascinating topic of quasars and black holes, and the lively recollections and at times controversial views of the contributors make ...

  9. Fifty Years of Research in ARDS. Gas Exchange in Acute Respiratory Distress Syndrome.

    Science.gov (United States)

    Radermacher, Peter; Maggiore, Salvatore Maurizio; Mercat, Alain

    2017-10-15

    Acute respiratory distress syndrome (ARDS) is characterized by severe impairment of gas exchange. Hypoxemia is mainly due to intrapulmonary shunt, whereas increased alveolar dead space explains the alteration of CO 2 clearance. Assessment of the severity of gas exchange impairment is a requisite for the characterization of the syndrome and the evaluation of its severity. Confounding factors linked to hemodynamic status can greatly influence the relationship between the severity of lung injury and the degree of hypoxemia and/or the effects of ventilator settings on gas exchange. Apart from situations of rescue treatment, targeting optimal gas exchange in ARDS has become less of a priority compared with prevention of injury. A complex question for clinicians is to understand when improvement in oxygenation and alveolar ventilation is related to a lower degree or risk of injury for the lungs. In this regard, a full understanding of gas exchange mechanism in ARDS is imperative for individualized symptomatic support of patients with ARDS.

  10. fifty years of oil exploration in nigeria: the paradox of plenty

    African Journals Online (AJOL)

    Admin

    against corruption. KEYWORDS: Resource curse, Nigeria, Oil and Gas, GDP, Infrastructure, Corruption. INTRODUCTION. The history of oil exploration in Nigeria ..... as the country failed to invest in the downstream sector of the petroleum industry. Table 4: Economic Indicators as at 2003. Parameters. Brazil. Mexico. Ghana.

  11. A Pictorial History of the Drury College Student: The First Fifty Years

    Science.gov (United States)

    Maddux, Mindy

    2011-01-01

    Established in 1873, Drury College in Springfield, Missouri, provided a unique experience for their undergraduate students. A limited amount of research has been conducted on the institution but no work has been done to specifically look at the undergraduate student experience. Using archival research methods and information from literature on…

  12. Fifty years of Yang-Mills Theories: a phenomenological point of view

    CERN Document Server

    De Rújula, Alvaro

    2005-01-01

    On the occasion of the celebration of the first half-century of Yang--Mills theories, I am contributing a personal recollection of how the subject, in its early times, confronted physical reality, that is, its "phenomenology". There is nothing original in this work, except, perhaps, my own points of view. But I hope that the older practitioners of the field will find here grounds for nostalgia, or good reasons to disagree with me. Younger addicts may learn that history does not resemble at all what is reflected in current textbooks: it was orders of magnitude more fascinating.

  13. Isotopes and innovation: MDS Nordion's first fifty years, 1946-1996

    International Nuclear Information System (INIS)

    Litt, P.

    2000-01-01

    Few people realize that Canada leads in the world in the production of radio isotopes, the raw material of nuclear medicine and high-tech scanners, and in their use in medicine and industry. In Isotopes and Innovation the author gives an in-depth look at MDS Nordion, a company that started as the radium sales department of Eldorado Mining and Refining, the Canadian uranium producer that was a key strategic resource for the Allies during the race to build the nuclear bomb, and went on to become the world?s leading producer of radioisotopes. When radium began to be used as a cancer treatment, Eldorado quickly became familiar with the medical marketplace and adept at developing products that could solve clinical problems and, more important, save lives. When Canadian nuclear reactors at Chalk River began producing radioisotopes that outperformed radium, Eldorado's radium sales department was transferred to a new crown corporation, Atomic Energy of Canada Limited, created to manage Canada's nuclear research establishment. The new company developed many useful applications for radioisotopes, including cobalt-60 cancer therapy machines and industrial sterilization plants. Bought by Medical Data Services Inc. in the early 1990s, MDS Nordion was a runaway success, creator and sole proprietor of several market-leading products. Isotopes and Innovation describes how a company capitalized on the byproducts of Canada's unique nuclear research program to attain a commanding international position in extremely specialized and demanding high-tech markets, a saga in which innovative research and enterprising global marketing have brought commercial success and saved countless lives around the world

  14. Draft Budget of the Organization for the Fifty-First Financial Year 2005

    CERN Document Server

    2004-01-01

    A sa réunion du 15 septembre 2004 , le Comité des finances a recommandé au Conseil d'approuver le projet préliminaire de budget 2005 aux prix de 2004. La présente version tient compte des transferts du budget 2004 présentés dans le document "Budget 2004 - Transferts et dépassements de crédits" , du prélèvement dans la réserve pour imprévus pour le LHC indiqué dans le document "Réserve pour imprévus pour le LHC" et de divers ajustements mineurs. En conséquence, il est demandé au Comité des finances de recommander au Conseil d'approuver les modifications par rapport au projet préliminaire de budget 2005 présentées dans les tableaux de l'annexe 1.

  15. Fifty years of Fanger's equation: Is there anything to discover yet?

    DEFF Research Database (Denmark)

    d'Ambrosio Alfano, Francesca Romana; Palella, Boris Igor; Riccio, Giuseppe

    2018-01-01

    This short communication to the Editor is completely devoted to a recent paper published by Broday et al. (2017) in which a comparative analysis of methods for determining the clothing surface temperature is reported. Contrarily to what our colleagues have found, we will demonstrate that the algo......This short communication to the Editor is completely devoted to a recent paper published by Broday et al. (2017) in which a comparative analysis of methods for determining the clothing surface temperature is reported. Contrarily to what our colleagues have found, we will demonstrate...

  16. Fifty Years of Mountain Passes: A Perspective on Dan Janzen's Classic Article.

    Science.gov (United States)

    Sheldon, Kimberly S; Huey, Raymond B; Kaspari, Michael; Sanders, Nathan J

    2018-05-01

    In 1967, Dan Janzen published "Why Mountain Passes Are Higher in the Tropics" in The American Naturalist. Janzen's seminal article has captured the attention of generations of biologists and continues to inspire theoretical and empirical work. The underlying assumptions and derived predictions are broadly synthetic and widely applicable. Consequently, Janzen's "seasonality hypothesis" has proven relevant to physiology, climate change, ecology, and evolution. To celebrate the fiftieth anniversary of this highly influential article, we highlight the past, present, and future of this work and include a unique historical perspective from Janzen himself.

  17. Isotopes and innovation: MDS Nordion's first fifty years, 1946-1996

    Energy Technology Data Exchange (ETDEWEB)

    Litt, P

    2000-07-01

    Few people realize that Canada leads in the world in the production of radio isotopes, the raw material of nuclear medicine and high-tech scanners, and in their use in medicine and industry. In Isotopes and Innovation the author gives an in-depth look at MDS Nordion, a company that started as the radium sales department of Eldorado Mining and Refining, the Canadian uranium producer that was a key strategic resource for the Allies during the race to build the nuclear bomb, and went on to become the world?s leading producer of radioisotopes. When radium began to be used as a cancer treatment, Eldorado quickly became familiar with the medical marketplace and adept at developing products that could solve clinical problems and, more important, save lives. When Canadian nuclear reactors at Chalk River began producing radioisotopes that outperformed radium, Eldorado's radium sales department was transferred to a new crown corporation, Atomic Energy of Canada Limited, created to manage Canada's nuclear research establishment. The new company developed many useful applications for radioisotopes, including cobalt-60 cancer therapy machines and industrial sterilization plants. Bought by Medical Data Services Inc. in the early 1990s, MDS Nordion was a runaway success, creator and sole proprietor of several market-leading products. Isotopes and Innovation describes how a company capitalized on the byproducts of Canada's unique nuclear research program to attain a commanding international position in extremely specialized and demanding high-tech markets, a saga in which innovative research and enterprising global marketing have brought commercial success and saved countless lives around the world.

  18. The Biggest Aspidistra in the World; A Personal Celebration of Fifty Years of the BBC.

    Science.gov (United States)

    Black, Peter

    This book is a personal recollection of the history of the British Broadcasting Corporation (BBC), written as a celebration of the BBC's fiftieth anniversary in 1972. The emphasis is on programs and people rather than policies. It is divided into roughly three periods: prewar, war, and postwar. The author writes, "The object is to remind…

  19. Fifty years of atmospheric radioactivity monitoring by the German Meteorological Service

    International Nuclear Information System (INIS)

    2006-01-01

    At a commemorative event at the Langen Training and Congress Center on 8 and 9 June 2005 it was brought to the attention of the audience that the German Meteorological Service has been charged with the sovereign task of monitoring atmospheric radioactivity since 8 August 1955. The purpose of this commission at the time was to measure traces of radioactivity in the atmosphere and precipitation and make forecasts on the movement of radioactive air masses. This was motivated by the above-ground nuclear tests carried out by the USA and the Soviet Union and the resulting measurable increase in atmospheric radioactivity levels. Equipped as it was with the necessary infrastructure the German Meteorological Service offered to take on this monitoring task. The importance of being able to assess the meteorological situation and provide data on radioactivity levels in the atmosphere and precipitation became apparent in 1986 after the reactor disaster of Chernobyl. When the Law on Preventive Radiation Protection was enacted in 1986 it was therefore only logical for the German Meteorological Service's commission to monitor atmospheric radioactivity levels to be renewed

  20. Normalization Fifty Years Beyond--Current Trends in the Nordic Countries

    Science.gov (United States)

    Tossebro, Jan; Bonfils, Inge S.; Teittinen, Antti; Tideman, Magnus; Traustadottir, Rannveig; Vesala, Hannu T.

    2012-01-01

    The authors discuss recent developments in services for people with intellectual disabilities (ID) in the Nordic countries. They note that all of the countries saw important reforms during the 1990s, regarding both deinstitutionalization and decentralization. However, they posit that the litmus test of the reforms is not what happens during reform…

  1. Cryogenics for high-energy particle accelerators: highlights from the first fifty years

    CERN Document Server

    AUTHOR|(CDS)2067931

    2017-01-01

    Applied superconductivity has become a key technology for high-energy particle accelerators, allowing to reach higher beam energy while containing size, capital expenditure and operating costs. Large and powerful cryogenic systems are therefore ancillary to low-temperature superconducting accelerator devices – magnets and high-frequency cavities – distributed over multi-kilometre distances and operating generally close to the normal boiling point of helium, but also above 4.2 K in supercritical and down to below 2 K in superfluid. Additionally, low-temperature operation in accelerators may also be required by considerations of ultra-high vacuum, limited stored energy and beam stability. We discuss the rationale for cryogenics in high-energy particle accelerators, review its development over the past half-century and present its outlook in future large projects, with reference to the main engineering domains of cryostat design and heat loads, cooling schemes, efficient power refrigeration and cryogenic flu...

  2. Truth in Reform: Reversing Fifty Years of Information Suppression in Burma

    Science.gov (United States)

    2014-10-30

    suit with a broader offering that includes next generation 3G services and legacy 2G services that are more affordable to most Burmese citizens. 46...with the same effect during the 2007 Saffron Revolution, when citizen journalists used grainy mobile phone video, Burmese Internet cafes, and web...Internet controls were not technically sophisticated, the government quickly resorted to a complete block on mobile and Internet access during the 2007

  3. Three-year monitoring study of radiocesium transfer and ambient dose rate in forest environments affected by the Fukushima Dai-ichi Nuclear Power Plant accident

    Science.gov (United States)

    Kato, Hiroaki; Onda, Yuichi; Loffredo, Nicolas; Kawamori, Ayumi; Hisadome, Keigo

    2015-04-01

    We investigated the transfer of canopy-intercepted radiocesium to the forest floor during 3 years (July 2011~) following the Fukushima Dai-ichi Nuclear Power Plant accident. The cesium-137 (Cs-137) contents of throughfall, stemflow, and litterfall were monitored in two coniferous stands (plantation of Japanese cedar) and a deciduous broad-leaved forest stand (Japanese oak with red pine). We also measured an ambient dose rate at different height in the forest by using a survey meter (TCS-172B, Hitachi-Aloka Medical, LTD.) and a portable Ge gamma-ray detector (Detective-DX-100T, Ortec, Ametek, Inc.). Furthermore, effects of forest decontamination on the reduction of ambient dose rate were assessed quantitatively. Total Cs-137 deposition flux from the canopy to forest floor for the mature cedar, young cedar, and the mixed broad-leaved stands were 157 kBq/m^2, 167 kBq/m^2, and 54 kBq/m^2, respectively. These values correspond to 36%, 39% and 12% of total atmospheric input after the accident. The ambient dose rate showed an exponential decrease with time for all the forest sites, however the decreasing trend differed depending on the forest type. These data suggested that an ambient dose rate in forest environment can be variable in spatially and temporally reflecting the transfer of radiocesium from canopy to forest floor. We presented the analysis results of the relationship between radiocesium deposition flux and ambient dose rate at the forest floor. In addition to that, we reported the effects of forest decontamination (e.g., tree felling, removal of organic materials, woodchip pavement) on the reduction of ambient dose rate in the forest environment.

  4. Population dose commitments due to radioactive releases from nuclear power plant sites in 1975

    International Nuclear Information System (INIS)

    Baker, D.A.; Soldat, J.K.; Watson, E.C.

    1977-10-01

    Population radiation dose commitments were estimated from reported radionuclide releases from commercial power reactors operating during 1975. Fifty-year dose commitments from one year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teenager and adult) residing between 2 and 80 km from each site. Results are given in the form of tables giving the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each site is a histogram showing the fraction of the total population within the 2 to 80-km region around each site receiving various average dose commitments from the airborne pathways. The total dose commitment from both liquid and airborne pathways ranged from a high of 750 person-rem to a low of 0.008 person-rem with an arithmetic mean of 34 person-rem

  5. Accelerated Partial Breast Irradiation With Low-Dose-Rate Interstitial Implant Brachytherapy After Wide Local Excision: 12-Year Outcomes From a Prospective Trial

    Energy Technology Data Exchange (ETDEWEB)

    Hattangadi, Jona A. [Harvard Radiation Oncology Program, Boston, MA (United States); Powell, Simon N. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); MacDonald, Shannon M.; Mauceri, Thomas; Ancukiewicz, Marek [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Freer, Phoebe [Department of Radiology, Massachusetts General Hospital, Boston, MA (United States); Lawenda, Brian [21st Century Oncology, Las Vegas, NV (United States); Alm El-Din, Mohamed A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY (United States); Department of Clinical Oncology, Tanta University Hospital, Tanta (Egypt); Gadd, Michele A.; Smith, Barbara L. [Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA (United States); Taghian, Alphonse G., E-mail: ataghian@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States)

    2012-07-01

    Purpose: To evaluate the long-term toxicity, cosmesis, and local control of accelerated partial breast irradiation with implant brachytherapy after wide local excision for Stage T1N0 breast cancer (BCa). Materials and Methods: Between 1997 and 2001, 50 patients with Stage T1N0M0 BCa were treated in a Phase I-II protocol using low-dose-rate accelerated partial breast irradiation with implant brachytherapy after wide local excision and lymph node surgery. The total dose was escalated in three groups: 50 Gy (n = 20), 55 Gy (n = 17), and 60 Gy (n = 13). Patient- and physician-assessed breast cosmesis, patient satisfaction, toxicity, mammographic abnormalities, repeat biopsies, and disease status were prospectively evaluated at each visit. Kendall's tau ({tau}{sub {beta}}) and logistic regression analyses were used to correlate outcomes with dose, implant volume, patient age, and systemic therapy. Results: The median follow-up period was 11.2 years (range, 4-14). The patient satisfaction rate was 67%, 67% reported good-excellent cosmesis, and 54% had moderate-severe fibrosis. Higher dose was correlated with worse cosmetic outcome ({tau}{sub {beta}} 0.6, p < .0001), lower patient satisfaction ({tau}{sub {beta}} 0.5, p < .001), and worse fibrosis ({tau}{sub {beta}} 0.4, p = .0024). Of the 50 patients, 35% had fat necrosis and 34% developed telangiectasias {>=}1 cm{sup 2}. Grade 3-4 late skin and subcutaneous toxicities were seen in 4 patients (9%) and 6 patients (13%), respectively, and both correlated with higher dose ({tau}{sub {beta}} 0.3-0.5, p {<=} .01). One patient had Grade 4 skin ulceration and fat necrosis requiring surgery. Mammographic abnormalities were seen in 32% of the patients, and 30% underwent repeat biopsy, of which 73% were benign. Six patients had ipsilateral breast recurrence: five elsewhere in the breast, and one at the implant site. One patient died of metastatic BCa after recurrence. The 12-year actuarial local control, recurrence

  6. Accelerated Partial Breast Irradiation With Low-Dose-Rate Interstitial Implant Brachytherapy After Wide Local Excision: 12-Year Outcomes From a Prospective Trial

    International Nuclear Information System (INIS)

    Hattangadi, Jona A.; Powell, Simon N.; MacDonald, Shannon M.; Mauceri, Thomas; Ancukiewicz, Marek; Freer, Phoebe; Lawenda, Brian; Alm El-Din, Mohamed A.; Gadd, Michele A.; Smith, Barbara L.; Taghian, Alphonse G.

    2012-01-01

    Purpose: To evaluate the long-term toxicity, cosmesis, and local control of accelerated partial breast irradiation with implant brachytherapy after wide local excision for Stage T1N0 breast cancer (BCa). Materials and Methods: Between 1997 and 2001, 50 patients with Stage T1N0M0 BCa were treated in a Phase I-II protocol using low-dose-rate accelerated partial breast irradiation with implant brachytherapy after wide local excision and lymph node surgery. The total dose was escalated in three groups: 50 Gy (n = 20), 55 Gy (n = 17), and 60 Gy (n = 13). Patient- and physician-assessed breast cosmesis, patient satisfaction, toxicity, mammographic abnormalities, repeat biopsies, and disease status were prospectively evaluated at each visit. Kendall’s tau (τ β ) and logistic regression analyses were used to correlate outcomes with dose, implant volume, patient age, and systemic therapy. Results: The median follow-up period was 11.2 years (range, 4–14). The patient satisfaction rate was 67%, 67% reported good-excellent cosmesis, and 54% had moderate-severe fibrosis. Higher dose was correlated with worse cosmetic outcome (τ β 0.6, p β 0.5, p β 0.4, p = .0024). Of the 50 patients, 35% had fat necrosis and 34% developed telangiectasias ≥1 cm 2 . Grade 3–4 late skin and subcutaneous toxicities were seen in 4 patients (9%) and 6 patients (13%), respectively, and both correlated with higher dose (τ β 0.3–0.5, p ≤ .01). One patient had Grade 4 skin ulceration and fat necrosis requiring surgery. Mammographic abnormalities were seen in 32% of the patients, and 30% underwent repeat biopsy, of which 73% were benign. Six patients had ipsilateral breast recurrence: five elsewhere in the breast, and one at the implant site. One patient died of metastatic BCa after recurrence. The 12-year actuarial local control, recurrence-free survival, and overall survival rate was 85% (95% confidence interval, 70–97%), 72% (95% confidence interval, 54–86%), and 87% (95

  7. The First Fifty ABO Blood Group Incompatible Kidney Transplantations: The Rotterdam Experience

    Directory of Open Access Journals (Sweden)

    Madelon van Agteren

    2014-01-01

    Full Text Available This study describes the single center experience and long-term results of ABOi kidney transplantation using a pretransplantation protocol involving immunoadsorption combined with rituximab, intravenous immunoglobulins, and triple immune suppression. Fifty patients received an ABOi kidney transplant in the period from 2006 to 2012 with a follow-up of at least one year. Eleven antibody mediated rejections were noted of which 5 were mixed antibody and cellular mediated rejections. Nine cellular mediated rejections were recorded. Two grafts were lost due to rejection in the first year. One-year graft survival of the ABOi grafts was comparable to 100 matched ABO compatible renal grafts, 96% versus 99%. At 5-year follow-up, the graft survival was 90% in the ABOi versus 97% in the control group. Posttransplantation immunoadsorption was not an essential part of the protocol and no association was found between antibody titers and subsequent graft rejection. Steroids could be withdrawn safely 3 months after transplantation. Adverse events specifically related to the ABOi protocol were not observed. The currently used ABOi protocol shows good short and midterm results despite a high rate of antibody mediated rejections in the first years after the start of the program.

  8. Optimizing the radiation therapy dose prescription for pediatric medulloblastoma: Minimizing the life years lost attributable to failure to control the disease and late complication risk

    DEFF Research Database (Denmark)

    Brodin, N. Patrik; Vogelius, Ivan R.; Bjork-Eriksson, Thomas

    2014-01-01

    Background. A mathematical framework is presented for simultaneously quantifying and evaluating the trade-off between tumor control and late complications for risk-based radiation therapy (RT) decision-support. To demonstrate this, we estimate life years lost (LYL) attributable to tumor recurrence...... is important, with 0.75 LYL (95% CI 0.60-7.2 years) for standard uniform 24 Gy CS irradiation. However, recurrence risk dominates the total LYL with 14.2 years (95% CI 13.4-16.6 years). Compared to standard treatment, a risk-adapted strategy prescribing 12 Gy to the spinal volume encompassing the 1st-10th......, late cardiac toxicity and secondary cancers for standard-risk pediatric medulloblastoma (MB) patients and compare the effect of dose re-distribution on a common scale. Methods. Total LYL were derived, based on the LYL attributable to radiation-induced late complications and the LYL from not controlling...

  9. High-dose rate brachytherapy in the treatment of carcinoma of uterine cervix: twenty-year experience with cobalt after-loading system.

    Science.gov (United States)

    Mosalaei, A; Mohammadianpanah, M; Omidvari, S; Ahmadloo, N

    2006-01-01

    This retrospective analysis aims to report results of patients with cancer of uterine cervix treated with external-beam radiotherapy (EBR) and high-dose rate (HDR) brachytherapy, using manual treatment planning. From 1975 to 1995, 237 patients with FIGO stages IIB-IVA and mean age of 54.31 years were treated. EBR dose to the whole pelvis was 50 Gy in 25 fractions. Brachytherapy with HDR after-loading cobalt source (Cathetron) was performed following EBR completion with a dose of 30 Gy in three weekly fractions of 10 Gy to point A. Survival, local control, and genitourinary and gastrointestinal complications were assessed. In a median follow-up of 60.2 months, the 10-year overall and disease-free survival rate was 62.4%. Local recurrence was seen in 12.2% of patients. Distant metastases to the lymph nodes, peritoneum, lung, liver, and bone occurred in 25.3% of patients. Less than 6% of patients experienced severe genitourinary and/or gastrointestinal toxicity that were relieved by surgical intervention. No treatment-related mortality was seen. This series suggests that 50 Gy to the whole pelvis together with three fractions of 10 Gy to point A with HDR brachytherapy is an effective fractionation schedule in the treatment of locally advanced cancer of cervix. To decrease the complications, newer devices and treatment planning may be beneficial.

  10. High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial.

    Science.gov (United States)

    Pearson, Andrew D J; Pinkerton, C Ross; Lewis, Ian J; Imeson, John; Ellershaw, Caroline; Machin, David

    2008-03-01

    The current standard treatment for patients with high-risk neuroblastoma includes initial induction chemotherapy with a 21-day interval between induction treatments. We aimed to assess whether an intensive chemotherapy protocol that had a 10-day interval between treatments would improve event-free survival (EFS) in patients aged 1 year or over with high-risk neuroblastoma. Between Oct 30, 1990, and March 18, 1999, patients with stage 4 neuroblastoma who had not received previous chemotherapy were enrolled from 29 centres in Europe. Patients were randomly assigned to rapid treatment (cisplatin [C], vincristine [O], carboplatin [J], etoposide [E], and cyclophosphamide [C], known as COJEC) or standard treatment (vincristine [O], cisplatin [P], etoposide [E], and cyclophosphamide [C], ie, OPEC, alternated with vincristine [O], carboplatin [J], etoposide [E], and cyclophosphamide [C], ie, OJEC). Both regimens used the same total cumulative doses of each drug (except vincristine), but the dose intensity of the rapid regimen was 1.8-times higher than that of the standard regimen. The standard regimen was given every 21 days if patients showed haematological recovery, whereas the rapid regimen was given every 10 days irrespective of haematological recovery. Response to chemotherapy was assessed according to the conventional International Neuroblastoma Response Criteria (INRC). In responders, surgical excision of the primary tumour was attempted, followed by myeloablation (with 200 mg/m2 of melphalan) and haemopoietic stem-cell rescue. Primary endpoints were 3-year, 5-year, and 10-year EFS. Data were analysed by intention to treat. This trial is registered on the clinical trials site of the US National Cancer Institute website, number NCT00365755, and also as EU-20592 and CCLG-NB-1990-11. 262 patients, of median age 2.95 years (range 1.03-20.97), were randomly assigned-132 patients to standard and 130 patients to rapid treatment. 111 patients in the standard group and 109

  11. Five-year follow-up of survival and relapse in patients who received cryotherapy during high-dose chemotherapy for stem cell transplantation shows no safety concerns.

    Science.gov (United States)

    Svanberg, A; Ohrn, K; Birgegård, G

    2012-11-01

    We have previously published a randomised controlled study of the efficacy of cryotherapy in preventing acute oral mucositis after high-dose chemotherapy for stem cell transplantation. The present study is a 5-year follow-up safety study of survival in these patients. In the previously published study oral cryotherapy (cooling of the oral cavity) during high-dose chemotherapy significantly reduced mucositis grade and opiate use in the treated group. All patients were followed up for at least 5 years with regard to relapse and death rates. Baseline data, transplant complications and mucositis data were compared. Significantly more patients (25/39) who received oral cryotherapy were alive after 5 years compared to 15/39 in the control group (P= 0.025). Relapse rates were similar. The only baseline difference was a lower proportion of patients in complete remission at transplantation in the control group (6 vs. 13, P= 0.047). This 5-year follow-up study gave no support for safety concerns with cryotherapy. © 2012 Blackwell Publishing Ltd.

  12. Doses from potential inhalation by people living near plutonium contaminated areas

    International Nuclear Information System (INIS)

    Iranzo Gonzales, E.; Salvador Ruiz, S.

    1983-09-01

    An aviation accident above the town of Palomares, Spain resulted in four thermonuclear bombs carried by one of the planes falling. The nuclear fuel in two of them ignited and formed an aerosol which contaminated a 226-hectare area of underbrush, farmland and an urban center. The magnitude of risk to people living in the area who may have inhaled the plutonium aerosol or dusts during the fifteen-year period since the time the accident is addressed in this report. In addition the internal radiation doses that people may have received during this period and during a fifty-year period commencing with the accident is estimated. In brief summary, the lungs received the greatest dose equivalent (1966 to 1980). Over the fifty year period (to 2015) the bones are projected to receive the greatest dose. For the remaining organs - liver-intestines-kidneys, - the relationships or between the doses that will be accumulated up to the year 2015 and the corresponding annual dose equivalent limits are less than those for the bones and lungs

  13. Symmetry and conservation laws in particle physics in the fifties

    International Nuclear Information System (INIS)

    Michel, L.

    1989-01-01

    This paper puzzles over why symmetry, so central to particle physics today, was so little attended to in the 1950s when the need for it was becoming profound, with the notion of parity violation and other break-downs in conservation laws, such as angular momentum and charge conjugation. Group theory, including Lie groups, would also have helped understanding of the particle physics discoveries of the 1950s such as strange particles, resonances, and associated production. They were adopted ten years too late by the physics community. (UK)

  14. A mathematical medley fifty easy pieces on mathematics

    CERN Document Server

    Szpiro, George G

    2010-01-01

    Szpiro's book provides a delightful, well-written, eclectic selection of mathematical tidbits that makes excellent airplane reading for anyone with an interest in mathematics, regardless of their mathematical background. Excellent gift material. -Keith Devlin, Stanford University, author of The Unfinished Game and The Language of Mathematics It is great to have collected in one volume the many varied, insightful and often surprising mathematical stories that George Szpiro has written in his mathematical columns for the newspapers through the years. -Marcus du Sautoy, Oxford University, author

  15. Measurement and Analysis of Output Radiation Dose on X-Ray Device over 10 Years at Hospitals in Medan City

    Directory of Open Access Journals (Sweden)

    Herty Afrina Sianturi

    2018-01-01

    Adhikari, Suraj Raj. 2012. Effect And Application      Of Ionization Radiation (X-Ray In Living  Organism. Kaski: Volume 3.The Himalaya  Physics. Badan Pengawas Tenaga Nuklir, Peraturan Kepala BAPETEN No. 8 Tahun 2011  tentang Keselamatan Radiasi dalam Penggunaan Pesawat Sinar-X Radiologi Diagnostik dan Intervensional, 2011. BAPETEN, 1999, Surat Keputusan Kepala Bapeten nomor 01/Ka-Bapeten/V-99 tentang Kesehatan terhadap radiasi pengion, Jakarta BATAN, 2005, Disain Penahan Ruang Sinar – X, Pusdiklat, BATAN, Jakarta Bushong, Steward C. 2013. Radologic Science for Technologists. 10th edition.United State of  America : CV. Mosby Company. Kramer, H. M., dan Selbach, H. J. 2008. Extension of the Range of Definition of the Practical Peak Voltage up to 300 kV. The British Journal of  Radiologhy (81:693-698. Rassad, S. dkk, Radiologi Diagnostik, Fakultas Kedokteran Universitas Indonesia Rumah Sakit Dr Cipto Mangunkusumo, Jakarta (2000. Suryanto, Sigit Bachtiar. 2011. Analisis Pembentukan Gambar Dan Batas Toleransi Uji Kesesuaian Pada Pesawat Sinar-X Diagnostik. Prosiding Seminar Penelitian Dan Pengelolaan Perangkat Nuklir. Trikasjono, T. dkk. 2009. Analisis Keselamatan Pesawat Sinar-X di Instalasi Radiologi Rumah Sakit Umum daerah Sleman Yogyakarta. Prosiding Seminar Nasional Sains dan Teknologi Nuklir PTNBR – BATAN. Vassileva, J. 2004. A Phantom for Dose Image Quality Optimization in Chest Radiography. The British Journal of Radiologhy 75:837-842. Wadianto, Azis Muslim. 2017. Uji Akurasi Tegangan Tinggi Alat Rontgen Radiography Mobile. INOVASI, Volume XIX Nomor 1,Januari 2017

  16. Optimizing the radiation therapy dose prescription for pediatric medulloblastoma: minimizing the life years lost attributable to failure to control the disease and late complication risk.

    Science.gov (United States)

    Brodin, N Patrik; Vogelius, Ivan R; Björk-Eriksson, Thomas; Munck Af Rosenschöld, Per; Maraldo, Maja V; Aznar, Marianne C; Specht, Lena; Bentzen, Søren M

    2014-04-01

    A mathematical framework is presented for simultaneously quantifying and evaluating the trade-off between tumor control and late complications for risk-based radiation therapy (RT) decision-support. To demonstrate this, we estimate life years lost (LYL) attributable to tumor recurrence, late cardiac toxicity and secondary cancers for standard-risk pediatric medulloblastoma (MB) patients and compare the effect of dose re-distribution on a common scale. Total LYL were derived, based on the LYL attributable to radiation-induced late complications and the LYL from not controlling the primary disease. We compared the estimated LYL for three different treatments in 10 patients: 1) standard 3D conformal RT; 2) proton therapy; 3) risk-adaptive photon treatment lowering the dose to part of the craniospinal (CS) target volume situated close to critical risk organs. Late toxicity is important, with 0.75 LYL (95% CI 0.60-7.2 years) for standard uniform 24 Gy CS irradiation. However, recurrence risk dominates the total LYL with 14.2 years (95% CI 13.4-16.6 years). Compared to standard treatment, a risk-adapted strategy prescribing 12 Gy to the spinal volume encompassing the 1st-10th thoracic vertebrae (Th1-Th10), and 36 Gy to the remaining CS volume, estimated a LYL reduction of 0.90 years (95% CI -0.18-2.41 years). Proton therapy with 36 Gy to the whole CS volume was associated with significantly fewer LYL compared to the risk-adapted photon strategies, with a mean LYL difference of 0.50 years (95% CI 0.25-2.60 years). Optimization of RT prescription strategies considering both late complications and the risk of recurrence, an all-cause mortality dose painting approach, was demonstrated. The risk-adapted techniques compared favorably to the standard, and although in this context, the gain is small compared to estimated uncertainty, this study demonstrates a framework for all-cause mortality risk estimation, rather than evaluates direct clinical applicability of risk

  17. The Colima Economy from fifties to the eighties

    Directory of Open Access Journals (Sweden)

    José Luis Villa Aguijosa

    2008-03-01

    Full Text Available The economic development of Colima, from 50s to 80s decades, was characterized for three stages which are differentiated for some certain features given by the roll that plays the economic sectors from the behaviour of some basic indicators of economic activities like port, agricultural, tourism, mining and industry, an for the economic strategy proposed during these years.In the 50s and 60s years, the economic of Colima took two fundamental characteristics which transcendent to the 70s decade: the supremacy in the participation in the agricultural sector in the gross state product, specialy given with impulse of the industrialization agricultural, and the mining activation, transforming in the base of economic development to Colima. The second stage, is in the 70s decade, and is characterized by the dynamic that industrial stage takes above other sectors with more slowly growing tax, besides it is characterized for one reduction of the growth tax of the gross estate product.The characteristics of economic development of Colima during these years are: standstill of the agricultural activity, trade and services, growth of industry, the urbanization and new economic profile, and makes the bases from the new economic profile of the 80s, in the context of the trade opening. The economy of Colima presented a regional polarization of the activities, a deficient communications and transports, a tourist potential misuse, an important growing of the industrial activities, and the necessity to expand the potential of the Manzanillo port and their big expectatives in the Mexican pacific, and an important growing of an industrial sector highly polarized. This panorama impacted in the profile of the development of Colima in the next decade.The third moment which crosses the economic of Colima, and is presented in the decade of the 80s, is characterized by the beginning of an economic model based in the planning which ;designs; an integrated Colima to the

  18. 76 FR 9786 - NIOSH Dose Reconstruction Program Ten-Year Review-Phase I Report on Customer Service; Request for...

    Science.gov (United States)

    2011-02-22

    ... Reconstruction Program Ten-Year Review--Phase I Report on Customer Service; Request for Public Review and Comment... Review--Phase I Report on Customer Service.'' This publication is part of a review by NIOSH of its... during the program review: The customer service provided by NIOSH in the program. The document can be...

  19. Sylvia Plath's The Bell Jar: a Mirror of American Fifties

    Directory of Open Access Journals (Sweden)

    Ghandeharion A.

    2015-12-01

    Full Text Available With its portrayal of a talented yet frustrated young American woman in the 1950s, Sylvia Plath's The Bell Jar (1963 depicts the experiences of a nineteen-year-old girl before her mental breakdown. Benefitting from a Friedanian second wave feminism, this paper aims to trace the root of disappointment and identity crisis in Plath's heroine, Esther Greenwood. It is understood that besides being a personal issue, her frustration is the outcome of sociocultural factors. The lack of role models and the contradictory messages sent by the media lead to her anxiety, disillusionment, and uncertainty. The Bell Jar proposes a solution: it is indeed possible for a woman to hold a fulfilling career and at the same time be a caring wife and a loving mother. And this is the answer Esther tries to figure out at a time when the boundaries between the domestic sphere and the outside world are clearly defined for women.

  20. Sylvia Plath's The Bell Jar: a Mirror of American Fifties

    Directory of Open Access Journals (Sweden)

    Ghandeharion, A.

    2015-01-01

    Full Text Available With its portrayal of a talented yet frustrated young American woman in the 1950s, Sylvia Plath's The Bell Jar (1963 depicts the experiences of a nineteen-year-old girl before her mental breakdown. Benefitting from a Friedanian second wave feminism, this paper aims to trace the root of disappointment and identity crisis in Plath's heroine, Esther Greenwood. It is understood that besides being a personal issue, her frustration is the outcome of sociocultural factors. The lack of role models and the contradictory messages sent by the media lead to her anxiety, disillusionment, and uncertainty. The Bell Jar proposes a solution: it is indeed possible for a woman to hold a fulfilling career and at the same time be a caring wife and a loving mother. And this is the answer Esther tries to figure out at a time when the boundaries between the domestic sphere and the outside world are clearly defined for women.

  1. High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution

    Science.gov (United States)

    Seldin, D. C.; Andrea, N.; Berenbaum, I.; Berk, J. L.; Connors, L.; Dember, L. M.; Doros, G.; Fennessey, S.; Finn, K.; Girnius, S.; Lerner, A.; Libbey, C.; Meier-Ewert, H. K.; O’Connell, R.; O’Hara, C.; Quillen, K.; Ruberg, F. L.; Sam, F.; Segal, A.; Shelton, A.; Skinner, M.; Sloan, J. M.; Wiesman, J. F.; Sanchorawala, V.

    2017-01-01

    Treatment with high-dose melphalan chemotherapy supported by hematopoietic rescue with autologous stem cells produces high rates of hematologic responses and improvement in survival and organ function for patients with AL amyloidosis. Ongoing clinical trials explore pre-transplant induction regimens, post-transplant consolidation or maintenance approaches, and compare transplant to non-transplant regimens. To put these studies into context, we reviewed our recent experience with transplant for AL amyloidosis in the Amyloid Treatment and Research Program at Boston Medical Center and Boston University School of Medicine. Over the past 10 years, there was a steady reduction in rates of treatment-related mortality and improvement in 1-year survival, now approximately 5% and 90%, respectively, based upon an intention-to-treat analysis. Median overall survival of patients treated with this approach at our center exceeds 7.5 years. PMID:21838459

  2. On the time development of the population dose in selected settlements of Korma county in Belarus about 13 years after the Chernobyl accident

    International Nuclear Information System (INIS)

    Dederichs, H.; Hill, P.; Hille, R.; Konoplya, E.

    2000-01-01

    After the reactor accident at Chernobyl in 1986 the time development of environmental contamination and population doses was investigated by several national and international institutions. One of the most comprehensive projects was the German three-year measuring campaign that was started in 1991. Though concerning the ingestion dose in-vivo monitoring proved, that the international annual dose limit of 1 mSv/a had only been exceeded in less than 2% of 317,000 cases, an a priori unexpected upward trend of mean annual doses showed the necessity of further studies to verify the long-term evaluation of the population dose. Several small follow-up studies were initiated in Belarus, Russia and the Ukraine. This paper reports especially on a study in Belarus, where two municipalities in Korma county were selected for further investigations: Wornovka, a purely agricultural municipality, and Volincy, an agricultural and forestal municipality. The ground contamination of these two areas was between 300 kBq/m 2 and 630 kBq/m 2 in 1991. In contrast to Wornovka the municipality of Volincy is surrounded by a contaminated forest area and isolated from the main part of Korma county by a highly contaminated evacuation zone and the river Sosch. Both the internal contamination of people as well as the contamination of the environment and food have been assessed using mobile in-vivo and environmental monitoring systems. Measurements of soil contamination in 1998 show a drop down to a mean of less than 200 kBq/m 2 in both municipalities. The evaluation of the internal contamination with time is however quite different: in the year 1992 the mean value at Wornovka was 0.8 kBq, 1.7 kBq in 1997 and 2.8 kBq in autumn 1998. At Volincy the internal contamination increased from 6.1 kBq in 1992 to 14.1 kBq in 1998 and even 51.2 kBq in early summer 1999 corresponding to an internal dose of about 2 mSv/a. Body burdens of up to 660 kBq 137 Cs have been observed. Due to the severe economic

  3. Howard Hughes Medical Institute dose assessment survey

    International Nuclear Information System (INIS)

    O'Brien, S.L.; McDougall, M.M.; Barkley, W.E.

    1996-01-01

    Biomedical science researchers often express frustration that health physics practices vary widely between individual institutions. A survey examining both internal and external dose assessment practices was devised and mailed to fifty institutions supporting biomedical science research. The results indicate that health physics dose assessment practices and policies are highly variable. Factors which may contribute to the degree of variation are discussed. 2 tabs

  4. Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA1c, and Insulin Dose.

    Science.gov (United States)

    Hao, Wei; Gitelman, Steven; DiMeglio, Linda A; Boulware, David; Greenbaum, Carla J

    2016-10-01

    We aimed to describe the natural history of residual insulin secretion in Type 1 Diabetes TrialNet participants over 4 years from diagnosis and relate this to previously reported alternative clinical measures reflecting β-cell secretory function. Data from 407 subjects from 5 TrialNet intervention studies were analyzed. All subjects had baseline stimulated C-peptide values of ≥0.2 nmol/L from mixed-meal tolerance tests (MMTTs). During semiannual visits, C-peptide values from MMTTs, HbA1c, and insulin doses were obtained. The percentage of individuals with stimulated C-peptide of ≥0.2 nmol/L or detectable C-peptide of ≥0.017 nmol/L continued to diminish over 4 years; this was markedly influenced by age. At 4 years, only 5% maintained their baseline C-peptide secretion. The expected inverse relationships between C-peptide and HbA1c or insulin doses varied over time and with age. Combined clinical variables, such as insulin-dose adjusted HbA1c (IDAA1C) and the relationship of IDAA1C to C-peptide, also were influenced by age and time from diagnosis. Models using these clinical measures did not fully predict C-peptide responses. IDAA1C ≤9 underestimated the number of individuals with stimulated C-peptide ≥0.2 nmol/L, especially in children. Current trials of disease-modifying therapy for type 1 diabetes should continue to use C-peptide as a primary end point of β-cell secretory function. Longer duration of follow-up is likely to provide stronger evidence of the effect of disease-modifying therapy on preservation of β-cell function. © 2016 by the American Diabetes Association.

  5. Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period.

    Science.gov (United States)

    Biason, Talita Poli; Goldberg, Tamara Beres Lederer; Kurokawa, Cilmery Suemi; Moretto, Maria Regina; Teixeira, Altamir Santos; Nunes, Hélio Rubens de Carvalho

    2015-04-03

    Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs. This was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 μg ethinylestradiol/150 μg desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann-Whitney test with the significance level fixed at 5% or p variations in the median percentages for bone mass variables. The COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p variation between COC users and non-users. Use of a low-dose COC (ethinylestradiol 20 μg/desogestrel 150 μg) was associated with lower bone mass acquisition in adolescents during the study period. Registry Number, RBR-5h9b3c.

  6. The fifty highest cited papers in anterior cruciate ligament injury.

    Science.gov (United States)

    Vielgut, Ines; Dauwe, Jan; Leithner, Andreas; Holzer, Lukas A

    2017-07-01

    The anterior cruciate ligament (ACL) is one of the most common injured knee ligaments and at the same time, one of the most frequent injuries seen in the sport orthopaedic practice. Due to the clinical relevance of ACL injuries, numerous papers focussing on this topic including biomechanical-, basic science-, clinical- or animal studies, were published. The purpose of this study was to determine the most frequently cited scientific articles which address this subject, establish a ranking of the 50 highest cited papers and analyse them according to their characteristics. The 50 highest cited articles related to Anterior Cruciate Ligament Injury were searched in Thomson ISI Web of Science® by the use of defined search terms. All types of scientific papers with reference to our topic were ranked according to the absolute number of citations and analyzed for the following characteristics: journal title, year of publication, number of citations, citation density, geographic origin, article type and level of evidence. The 50 highest cited articles had up to 1624 citations. The top ten papers on this topic were cited 600 times at least. Most papers were published in the American Journal of Sports Medicine. The publication years spanned from 1941 to 2007, with the 1990s and 2000s accounting for half of the articles (n = 25). Seven countries contributed to the top 50 list, with the USA having by far the most contribution (n = 40). The majority of articles could be attributed to the category "Clinical Science & Outcome". Most of them represent a high level of evidence. Scientific articles in the field of ACL injury are highly cited. The majority of these articles are clinical studies that have a high level of evidence. Although most of the articles were published between 1990 and 2007, the highest cited articles in absolute and relative numbers were published in the early 1980s. These articles contain well established scoring- or classification systems. The

  7. High-dose preoperative radiation for cancer of the rectum: Impact of radiation dose on patterns of failure and survival

    International Nuclear Information System (INIS)

    Ahmad, N.R.; Mohiuddin, M.; Marks, G.

    1993-01-01

    A variety of dose-time schedules are currently used for preoperative radiation therapy of rectal cancer. An analysis of patients treated with high-dose preoperative radiation therapy was undertaken to determine the influence of radiation dose on the patterns of failure, survival, and complications. Two hundred seventy-five patients with localized rectal cancer were treated with high-dose preoperative radiation therapy. One hundred fifty-six patients received 45 Gy (low-dose group). Since 1985, 119 patients with clinically unfavorable cancers were given a higher dose, 55 Gy using a shrinking field technique (high-dose group). All patients underwent curative resection. Median follow-up was 66 months in the low-dose group and 28 months in the high-dose group. Patterns of failure, survival, and complications were analyzed as a function of radiation dose. Fourteen percent of the total group developed a local recurrence; 20% in the low-dose group as compared with 6% in the high-dose group. The actuarial local recurrence rate at 5 years was 20% for the low-dose group and 8% for the high-dose group, and approached statistical significance with p = .057. For tethered/fixed tumors the actuarial local recurrence rates at 5 years were 28% and 9%, respectively, with p = .05. Similarly, for low-lying tumors (less than 6 cm from the anorectal junction) the rates were 24% and 9%, respectively, with p = .04. The actuarial rate of distant metastasis was 28% in the low-dose group and 20% in the high-dose group and was not significantly different. Overall actuarial 5-year survival for the total group of patients was 66%. No significant difference in survival was observed between the two groups, despite the higher proportion of unfavorable cancers in the high-dose group. The incidence of complications was 2%, equally distributed between the two groups. High-dose preoperative radiation therapy for rectal cancer results in excellent local control rates. 27 refs., 2 figs., 8 tabs

  8. Estimates of radiation doses due to ingested radiocesium and strontium 90 to the Romanian population. The second and the third year after the Chernobyl accident

    International Nuclear Information System (INIS)

    Botezatu, E.; Iacob, O.

    1992-01-01

    The paper reports the data provided by all the Romanian radiation hygiene laboratories from the Institutes of Hygiene and Public Health and the Regional Prophylactic Medicine Centers. The 134 Cs, 137 Cs and 90 Sr concentrations in some 20,000 various samples (water and foodstuff) were determined after the Chernobyl accident, as part of a long-term sanitary surveillance programme. The measurements were performed by using gamma spectroscopy and radiochemical analysis. As expected, measurements of 90 Sr and radiocesium concentrations in the samples collected from all over Romania showed a grater contamination with radiocesium. The levels of the contamination have greatly decreased during the period of 30 April 1987 - 30 April 1989. Charting the levels of food radioactivity, it was possible to divide Romania into three zones. These zones overlap pretty well those of the 137 Cs deposition (UNSCEAR 1988). Doses from ingestion of contaminated foods were calculated as products of average concentration in foods, consumption amounts and age specific dose per unit intake factors. The effective dose equivalent received by individuals (children and adults) during the second and third year following the accident were determined. (author) 1 fig., 7 tabs., 13 refs

  9. Tandem high-dose chemotherapy and auto-SCT for malignant brain tumors in children under 3 years of age.

    Science.gov (United States)

    Sung, K W; Lim, D H; Lee, S H; Yoo, K H; Koo, H H; Kim, J H; Suh, Y-L; Joung, Y S; Shin, H J

    2013-07-01

    In an effort to improve survival and reduce late adverse effects of radiation therapy (RT), 25 children SCT following six cycles of induction chemotherapy. RT was either not given or deferred until 3 years of age if the patient was in CR after tandem HDCT/auto-SCT. Tumors relapsed or progressed in nine patients (five during induction treatment), and two of these patients survived after receiving salvage treatment, including RT. Two patients died due to toxicities during tandem HDCT/auto-SCT. A total of 16 patients survived to a median follow-up period of 52 months (range 18-96) from the time of diagnosis. Four of these patients did not receive RT, two received local RT (L-RT), three received craniospinal RT (CSRT), and seven received both L-RT and CSRT. The 5-year OS and EFS rates were 67.8±9.4% and 55.5±10.0%, respectively. Neuroendocrine and neurocognitive functions evaluated 3 years after tandem HDCT/auto-SCT were acceptable. Our results indicate that tandem HDCT/auto-SCT may improve survival in young children with malignant brain tumors with an acceptable level of risk of long-term toxicity.

  10. Once-Weekly, High-Dose Stereotactic Body Radiotherapy for Lung Cancer: 6-Year Analysis of 60 Early-Stage, 42 Locally Advanced, and 7 Metastatic Lung Cancers

    International Nuclear Information System (INIS)

    Salazar, Omar M.; Sandhu, Taljit S.; Lattin, Paul B.; Chang, Jung H.; Lee, Choon K.; Groshko, Gayle A.; Lattin, Cheryl J.

    2008-01-01

    Purpose: To explore once-weekly stereotactic body radiotherapy (SBRT) in nonoperable patients with localized, locally advanced, or metastatic lung cancer. Methods and Materials: A total of 102 primary (89 untreated plus 13 recurrent) and 7 metastatic tumors were studied. The median follow-up was 38 months, the average patient age was 75 years. Of the 109 tumors studied, 60 were Stage I (45 IA and 15 IB), 9 were Stage II, 30 were Stage III, 3 were Stage IV, and 7 were metastases. SBRT only was given in 73% (40 Gy in four fractions to the planning target volume to a total dose of 53 Gy to the isocenter for a biologically effective dose of 120 Gy 10 ). SBRT was given as a boost in 27% (22.5 Gy in three fractions once weekly for a dose of 32 Gy at the isocenter) after 45 Gy in 25 fractions to the primary plus the mediastinum. The total biologically effective dose was 120 Gy 10 . Respiration gating was used in 46%. Results: The overall response rate was 75%; 33% had a complete response. The overall response rate was 89% for Stage IA patients (40% had a complete response). The local control rate was 82%; it was 100% and 93% for Stage IA and IB patients, respectively. The failure rate was 37%, with 17% within the planning target volume. No Grade 3-4 acute toxicities developed in any patient; 12% and 7% of patients developed Grade 1 and 2 toxicities, respectively. Late toxicity, all Grade 2, developed in 3% of patients. The 5-year cause-specific survival rate for Stage I was 70% and was 74% and 64% for Stage IA and IB patients, respectively. The 3-year Stage III cause-specific survival rate was 30%. The patients with metastatic lung cancer had a 57% response rate, a 27% complete response rate, an 86% local control rate, a median survival time of 19 months, and 23% 3-year survival rate. Conclusions: SBRT is noninvasive, convenient, fast, and economically attractive; it achieves results similar to surgery for early or metastatic lung cancer patients who are older

  11. Development of artificial radioactivity in the French environment during the past 50 years and related doses; effect of the current operation of nuclear facilities

    International Nuclear Information System (INIS)

    Renaud, Ph.; Roussel-Debet, S.

    2010-01-01

    The activities of artificial radionuclides in the environment have being strongly decreasing since 50 years. Nowadays the activities of 3 H and 14 C widely predominate, but they cannot be still considered as artificial radionuclides, except nearby the nuclear installations where they constitute the most abundant radioactive releases. In terrestrial environment this influence is limited to the surroundings of 5 sites, although most of nuclear sites and nuclear medical centers are involved in the contamination of the aquatic environment downstream the releases and in the Channel. Since 1987 the doses to the French population have been mainly induced by 14 C and 137 Cs. (author)

  12. Uterine cervix cancer treatment in IIB, IIIA and IIIB stages with external radiotherapy versus external radiotherapy and scintiscanning of low dose. ION SOLCA. Years 1998-2000

    International Nuclear Information System (INIS)

    Sanchez, Doris; Falquez, Roberto

    2002-01-01

    We realized study of retrospective accomplished in course of years 1998-2000, reviewing clinical charts of statistical department of ION SOLCA. We reviewed 544 cases in 1998, 603 patients in 1999, and 630 cases in 2000. In the radiotherapy service, 133 patients received treatment with external radiotherapy between February 1998 to February 1999 in IIB, IIIA, IIIB stages and only 80 patients were treated with external radiotherapy and scintiscanning of low dose rate in the same stages between March 1999 to March 2000. (The author)

  13. 25 years of Chernobyl: Countermeasures are still required to keep radiation doses to reindeer herders under the recommended limits; 25 aar med Tsjernobyl: Mottiltak er framleis noedvendige for aa halde straaledosane til reindriftsutoevarane under tilraadde grenser

    Energy Technology Data Exchange (ETDEWEB)

    2011-07-01

    The government's goal was that no one should get radiation doses above 5 mSv the first year after the Chernobyl accident, and not more than 1 mSv per year in the following years. Radiation doses to reindeer herders in the most polluted areas in North-Troendelag and Nordland would have been about 10 mSv per year at most without all the measures that was initiated. From 1986 to 2009 was radiation doses to reindeer herders in Snaasa region reduced with approx. 70%, and in the Roeros region with approx. 40%. (AG)

  14. The effect of eight half-yearly single-dose treatments with DEC on Wuchereria bancrofti circulating antigenaemia

    DEFF Research Database (Denmark)

    Simonsen, Paul E; Magesa, Stephen M; Meyrowitsch, Dan W

    2005-01-01

    The effect of eight half-yearly treatment rounds with diethylcarbamazine (DEC; 6mg/kg bodyweight) on Wuchereria bancrofti-specific circulating filarial antigen (CFA), a marker of adult worm infection, was followed in 79 individuals who were CFA-positive before start of treatment. Half of these we...... values. Repeated DEC therapy thus appears to have a slow but profound and persistent macrofilaricidal effect, which in the long run may be beneficial to populations undergoing DEC-based control interventions by reducing the probability of future morbidity development....

  15. Efficacy and tolerability of treatment with single doses of diethylcarbamazine (DEC) and DEC plus albendazole (ABZ) for three consecutive years in lymphatic filariasis: a field study in India.

    Science.gov (United States)

    Kshirsagar, Nilima A; Gogtay, N J; Garg, B S; Deshmukh, P R; Rajgor, D D; Kadam, V S; Thakur, P A; Gupta, A; Ingole, N S; Lazdins-Helds, J K

    2017-10-01

    Lymphatic filariasis (LF) affects 73 countries, causes morbidity and impedes socioeconomic development. We had found no difference in safety and micro (Mf) and macro filarial action of single-dose diethylcarbamazine (DEC) and DEC + albendazole (ABZ) in an F01 study done in India (year 2000). There was a programmatic need to evaluate safety and efficacy of multiple annual treatments (F02). Subjects (155) from the F01 study, meeting inclusion-exclusion criteria, were enrolled in F02 and treated with further two annual doses of DEC or DEC + ABZ. Efficacy was evaluated for Mf positivity by peripheral smear (PS) and nucleopore (NP) filter, circulating filarial antigen (CFA) and filarial dance sign (FDS) positivity and Mf count at yearly follow-up. Safety was assessed for 5 days after drug administration. Total of 139 subjects evaluated for efficacy (69 DEC and 70 DEC + ABZ group). Mf positivity prevalence declined progressively by 95% (PS), 66% (NP), and 95% (PS) and 86% (NP); CFA positivity prevalence declined by 15% and 9%; FDS by 100% each; Mf count declined by 75.5 and 76.9% with three annual treatment of DEC and DEC + ABZ, respectively. Addition of ABZ did not show any advantage over DEC given as three annual rounds for LF. DEC and DEC + ABZ were well tolerated. There was no correlation between result of CFA and FDS, (both claimed to be indicative of adult worm). Analysis of published studies and our data indicate that macrofilaricidal effect of DEC/DEC + ABZ may be seen in children and not adults, with three or more annual dosing.

  16. Predicting Grief Reactions One Year Following a Mass University Shooting: Evaluating Dose-Response and Contextual Predictors.

    Science.gov (United States)

    Smith, Andrew J; Layne, Christopher M; Coyle, Patrick; Kaplow, Julie B; Brymer, Melissa J; Pynoos, Robert S; Jones, Russell T

    2017-12-01

    This study identifies risk factors for grief following a mass school shooting. Participants (N = 1,013) completed online questionnaires 3-4 months (Time 1) and 1 year (Time 2) post-shootings. We tested models predicting Time 2 grief reactions, exploring direct and indirect predictive effects of exposure variables (physical and social proximity) through hypothesized peritraumatic mediators (peritraumatic perceived threat to self or others) while controlling for Time 1 grief and posttraumatic stress (PTS) reactions, pretrauma vulnerabilities. Findings demonstrate that closer social proximity predicted higher levels of Time 2 grief, directly and indirectly through increasing peritraumatic perceived threat to others' safety. Physical proximity and peritraumatic threat to self did not predict Time 2 grief reactions. Implications for grief screening instruments and theory building research through identifying risk factors and causal mechanisms are discussed.

  17. High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period

    Directory of Open Access Journals (Sweden)

    W. Louis Cleveland

    2009-01-01

    Full Text Available This paper describes an individual who was diagnosed with obsessive-compulsive disorder (OCD and body dysmorphic disorder (BDD at age 17 when education was discontinued. By age 19, he was housebound without social contacts except for parents. Adequate trials of three selective serotonin reuptake inhibitors, two with atypical neuroleptics, were ineffective. Major exacerbations following ear infections involving Group A -hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. At age 22, another severe exacerbation followed antibiotic treatment for H. pylori. This led to a hypothesis that postulates deficient signal transduction by the N-methyl-D-aspartate receptor (NMDAR. Treatment with glycine, an NMDAR coagonist, over 5 years led to robust reduction of OCD/BDD signs and symptoms except for partial relapses during treatment cessation. Education and social life were resumed and evidence suggests improved cognition. Our findings motivate further study of glycine treatment of OCD and BDD.

  18. "Double crap!" abuse and harmed identity in Fifty Shades of Grey.

    Science.gov (United States)

    Bonomi, Amy E; Altenburger, Lauren E; Walton, Nicole L

    2013-09-01

    While intimate partner violence (IPV) affects 25% of women and impairs health, current societal conditions-including the normalization of abuse in popular culture such as novels, film, and music-create the context to support such violence. Fifty Shades of Grey, a best-selling novel, depicts a "romantic" and "erotic" relationship involving 28-year-old megamillionaire, Christian Grey, and a 22-year-old college student, Anastasia Steele. We argue that the relationship is characterized by IPV, which is harmful to Anastasia. All authors engaged in iterative readings of the text, and wrote narrative summaries to elucidate themes. Validity checks included double review of the first eight chapters of the novel to establish consistency in our analysis approach, iterative discussions in-person and electronically to arbitrate discrepancies, and review of our analysis with other abuse and sexual practice experts. To characterize IPV, we used the U.S. Centers for Disease Control and Prevention's definitions of emotional abuse (intimidation/threats; isolation; stalking; and humiliation) and sexual violence (forced sex acts/contact against a person's will, including using alcohol/drugs or intimidation/pressure). To characterize harm, we used Smith's conceptualizations of perceived threat, managing, altered identity, yearning, entrapment, and disempowerment experienced by abused women. Emotional abuse is present in nearly every interaction, including: stalking (Christian deliberately follows Anastasia and appears in unusual places, uses a phone and computer to track Anastasia's whereabouts, and delivers expensive gifts); intimidation (Christian uses intimidating verbal and nonverbal behaviors, such as routinely commanding Anastasia to eat and threatening to punish her); and isolation (Christian limits Anastasia's social contact). Sexual violence is pervasive-including using alcohol to compromise Anastasia's consent, as well as intimidation (Christian initiates sexual encounters

  19. Estimate of radiation detriment long period after exposure to low doses of ionizing radiation: Chromosomal aberrations in liquidators 6-10 years after the Chernobyl accident

    International Nuclear Information System (INIS)

    Nikiforov, A.M.; Slozina, N.M.; Neronova, E.G.; Kharchenko, T.V.; Drygina, L.B.; Strukov, E.L.

    1997-01-01

    The group of 297 liquidators was cytogenetically investigated 6 - 10 years after the Chernobyl accident. The significantly increased level of chromosomal and chromatid types exchange aberrations was shown. For all subjects questionnaires that provide consideration of known and suspected confounding variables were filled in. The participation in recovery works at the Chernobyl nuclear power station was the only reason for dicentrics and rings rise in liquidators. An investigation of the tumor-specific markers (CEA, AFP, CA19-9, PSA, NSE) was carried out in 56 liquidators simultaneously with chromosomal analysis. The increased level of NSE was found in liquidators bearing the chromosomal aberrations of exchange type. The results of this work let us to consider the liquidators who underwent to low doses of ionizing radiation 6-10 years ago as a detrimental group that needs special scientific and medical attention. (author)

  20. Single-Dose Universal Hepatitis A Immunization in Argentina: Low Viral Circulation and High Persistence of Protective Antibodies Up to 4 Years.

    Science.gov (United States)

    Vizzotti, C; González, J; Rearte, A; Urueña, A; Pérez Carrega, M; Calli, R; Gentile, A; Uboldi, A; Ramonet, M; Cañero-Velasco, M; Diosque, M

    2015-12-01

    Single-dose hepatitis A virus (HAV) vaccination was implemented in all Argentinean children aged 12 months in 2005. Between 2005 and 2011, a dramatic decline was observed in HAV infection rates, fulminant hepatitis, and liver transplantation. This study assessed current viral circulation and estimated protective antibody persistence 4 years after vaccination. Prevalence of prevaccination anti-HAV antibodies in 12-month-old children was evaluated as an indirect estimation of viral circulation (Group A). Seroprevalence was also measured in 5-year-old children who received 1 dose of HAV vaccine at 1 year of age (Group B). Blood samples were tested for immunoglobulin (Ig)G anti-HAV antibodies (seroprotection = ≥10 mIU/mL). All Group A-positive samples were tested for IgM anti-HAV antibodies to identify recent infections. Logistic regression analysis was done to evaluate associations between demographic and socioeconomic variables and seroprotection. Of 433 children from Group A, 29.5% (95% confidence interval [CI], 25.2-33.8) were positive for IgG anti-HAV antibodies with a geometric mean concentration (GMC) of 6.17 mIU/mL (95% CI, 5.33-7.15 mIU/mL); all IgM anti-HAV were negative. From 1139 in Group B, 93% (95% CI, 91.7-94.6) maintained seroprotection with a GMC of 97.96 mIU/mL (95% CI, 89.21-107.57 mIU/mL). Kindergarten attendance was associated with seroprotection in Group B (odds ratio [OR], 2.0; 95% CI, 1.26-3.3). In contrast, high maternal educational level was associated with a lack of seroprotection in this group (OR, .26; 95% CI, .09-.8). Single-dose, universal hepatitis A immunization in infants resulted in low HAV circulation and persistent immunologic protection up to 4 years in Argentina. Variables associated with presence or absence of seroprotection in vaccinated children could be related to differences in hygiene habits in settings with residual viral circulation. © The Author 2014. Published by Oxford University Press on behalf of the Pediatric

  1. Fifty Violins.

    Science.gov (United States)

    Hurwitz, Sol

    1999-01-01

    Roberta Guaspari-Tzavoras teaches 125 young violinists in 2 East Harlem elementary schools. Students are chosen by lottery. The only prerequisite is a willingness to do the hard work of practicing and learning. Her success in coaching inner-city students to a performance in Carnegie hall is the subject of a documentary and a feature film. (MLF)

  2. Representasi Perempuan Dalam Film (Analisis Semiotika Representasi Perempuan Dalam Film “Fifty Shades of Grey”)

    OpenAIRE

    Aviomeita, Friska

    2016-01-01

    This study entitled "Representation of Women In Film ( Roland Barthes Semiotics Analysis In the film Fifty Shades of Grey ) " . The purpose of this study to find out how women are represented in the film " Fifty Shades of Grey " by denotation , connotation and myths . Film has always influenced and shaped the public based on the contents of the message behind it. Messages or values contained in the film may affect the audience. In this study, researchers used several theorie...

  3. High-Dose-Rate Brachytherapy and External-Beam Radiotherapy for Hormone-Naïve Low- and Intermediate-Risk Prostate Cancer: A 7-Year Experience

    International Nuclear Information System (INIS)

    Aluwini, Shafak; Rooij, Peter H. van; Kirkels, Wim J.; Jansen, Peter P.; Praag, John O.; Bangma, Chris H.; Kolkman-Deurloo, Inger-Karine K.

    2012-01-01

    Purpose: To report clinical outcomes and early and late complications in 264 hormone-naïve patients with low- and intermediate-risk prostate cancer treated with high-dose-rate brachytherapy (HDR-BT) in combination with external-beam radiotherapy (EBRT). Methods and Materials: Between February 2000 and July 2007, 264 patients underwent HDR-BT in combination with EBRT as a treatment for their low- to intermediate-risk prostate cancer. The HDR-BT was performed using ultrasound-based implantation. The total HDR-BT dose was 18 Gy in 3 fractions within 24 h, with a 6-h minimum interval. The EBRT started 2 weeks after HDR-BT and was delivered in 25 fractions of 1.8 Gy to 45 Gy within 5 weeks. Results: After a mean follow-up of 74.5 months, 4 patients (1.5%) showed prostate-specific antigen progression according to the American Society for Radiation Oncology definition and 8 patients (3%) according to the Phoenix definition. A biopsy-proven local recurrence was registered in 1 patient (0.4%), and clinical progression (bone metastases) was documented in 2 patients (0.7%). Seven-year actuarial freedom from biochemical failure was 97%, and 7-year disease-specific survival and overall survival were 100% and 91%, respectively. Toxicities were comparable to other series. Conclusions: Treatment with interstitial HDR-BT plus EBRT shows a low incidence of late complications and a favorable oncologic outcome after 7 years follow-up.

  4. A 1 year retrospective audit of quality indicators of clinical pharmacological advice for personalized linezolid dosing: one stone for two birds?

    Science.gov (United States)

    Pea, Federico; Cojutti, Piergiorgio; Dose, Lucia; Baraldo, Massimo

    2016-02-01

    This study explored the clinical and economic impact of clinical pharmacological advice (CPA) (based on therapeutic drug monitoring [TDM] results, and on patients' characteristics and co-medications) on personalized linezolid therapy in a tertiary care hospital. A 1 year retrospective analysis of quality indicators of CPA (clinicians' adherence rate to CPA, pre-post rate of linezolid trough concentrations within the desired range and cost balance analysis) was conducted. Five hundred and forty-four CPAs were provided to clinicians during 2014 for personalizing linezolid therapy in 168 patients. Clinicians' adherence to CPAs was very high (94.7%). The pre-post rate of linezolid Cmin distribution showed a favourable impact of CPA on patient care (pre-post ratio of Cmin within the desired range + 23.4%, pre, 51.2% vs. post, 74.6%). Overall, linezolid dosage was mainly reduced (56.9% of cases), whereas dose augmentation was needed only in a minority of cases (7.7%). Cost balance analysis showed that overall 1258 standard doses of linezolid (unitary dose 600 mg) were spared for treating 168 patients with a personalized dosage for a median duration of 11 days (range 3-128 days) with a cost saving of 60038.05 €. Active computerized advice elaborated by the clinical pharmacologist on the basis of TDM results and of patient's pathophysiological data and co-medications may be cost-effective for personalizing linezolid treatment. © 2015 The British Pharmacological Society.

  5. From personnel dose to personal dose

    International Nuclear Information System (INIS)

    Hoefert, M.; Raffnsoe, R.C.; Tuyn, J.W.N.; Wittekind, D.

    1985-01-01

    From following the development of personnel doses at CERN over the past six years it has become evident that work in areas of induced radioactivity is the principal cause of exposure. The results of photon dose measurements free-in-air and around a phantom are presented and discussed in the light of new quantities in individual monitoring. The importance of these results, with respect to the practical situation, is discussed and the problem of phantom size is mentioned. Finally, the results of dose measurements in the phantom are presented, since such information is important in cases where it becomes necessary to transform personnel doses into personal doses. (author)

  6. Estimation of committed effective dose from radioactive caesium contained in kindergarten supply of food during one year after Fukushima Daiichi Nuclear Power Plant accident

    International Nuclear Information System (INIS)

    Midorikawa, Miho; Hayashi, Toru

    2013-01-01

    For the purpose of contributing to an understanding about the situation of radioactive contamination of kindergarten lunch, contents of radioactive caesium and 40 K in lunch supplied by the attached kindergarten of Seitoku University was calculated by using the data on radioactive contamination of foodstuffs published by the Japanese Government. The average value of daily intake of radioactive caesium was estimated at lower than 1Bq and that of 40 K was 8.6Bq. Total amount of radioactive caesium in the lunch for one year was about 100Bq and that of 40 K was 1100Bq, resulting in a committed effective dose from radioactive caesium at about 1μSv. (author)

  7. Use of social media is associated with short sleep duration in a dose-response manner in students aged 11 to 20 years.

    Science.gov (United States)

    Sampasa-Kanyinga, Hugues; Hamilton, Hayley A; Chaput, Jean-Philippe

    2018-04-01

    This study examined the association between social media and sleep duration among Canadian students aged 11-20. Data from 5242 students were obtained from the 2015 Ontario Student Drug Use and Health Survey, a province-wide, school-based survey that has been conducted every two years since 1977. We measured the respondents' sleep duration against the recommended ranges of 9-11 h per night at 11-13 years of age, 8-10 h at 14-17 and 7-9 h per night for those aged 18 years or more. Overall, 36.4% of students met or exceeded the recommended sleep duration and 63.6% slept less than recommended, with 73.4% of students reporting that they used social media for at least one hour per day. After adjusting for various covariates, the use of social media was associated with greater odds of short sleep duration in a dose-response manner (p for linear trend fashion among Canadian students aged 11-20. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  8. Population dose commitments due to radioactive releases from nuclear power plant sites in 1987

    International Nuclear Information System (INIS)

    Baker, D.A.

    1990-08-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1987. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 70 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for reach of the sites is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The site average individual dose commitment from all pathways ranged from a low of 2 x 10 -6 mrem to a high of 0.009 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites. However, licensee calculation of doses to the maximally exposed individual at some sites indicated values of up to approximately 100 times average individual doses (on the order of a few millirem per year). 2 refs., 2 figs., 7 tabs

  9. Population dose commitments due to radioactive releases from nuclear power plant sites in 1982. Volume 4

    International Nuclear Information System (INIS)

    Baker, D.A.; Peloquin, R.A.

    1986-06-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1982. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 51 sites. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each site is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitments from both liquid and airborne pathways ranged from a high of 30 person-rem to a low of 0.007 person-rem for the sites with plants operating throughout the year with an arithmetic mean of 3 person-rem. The total population dose for all sites was estimated at 130 person-rem for the 100 million people considered at risk. The average individual dose commitment from all pathways on a site basis ranged from a low of 6 x 10 -7 mrem to a high of 0.06 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites

  10. Population dose commitments due to radioactive releases from nuclear power plant sites in 1986

    International Nuclear Information System (INIS)

    Baker, D.A.

    1989-10-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1986. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 66 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 31 person-rem to a low of 0.0007 person-rem for the sites with plants operating throughout the year with an arithmetic mean of 1.7 person-rem. The total population dose for all sites was estimated at 110 person-rem for the 140 million people considered at risk. The site average individual dose commitment from all pathways ranged from a low of 2 x 10 -6 mrem to a high of 0.02 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites. 12 refs

  11. Population dose commitments due to radioactive releases from nuclear power plant sites in 1984

    International Nuclear Information System (INIS)

    Baker, D.A.

    1988-01-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1984. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 56 sites. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each of the sites is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 110 person-rem to a low of 0.002 person-rem for the sites with plants operating throughout the year with an arithmetic mean of 5 person-rem. The total population dose for all sites was estimated at 280 person-rem for the 100 million people considered at risk. The site average individual dose commitment from all pathways ranged from a low of 6 x 10 -6 mrem to a high of 0.04 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites

  12. Population dose commitments due to radioactive releases from nuclear power plant sites in 1985

    International Nuclear Information System (INIS)

    Baker, D.A.

    1988-08-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commericial power reactors operating during 1985. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 61 sites. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each of the sites is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 73 person-rem to a low of 0.011 person-rem for the sites with plants operating throughout the year with an arithmetic mean of 3 person-rem. The total population dose for all sites was estimated at 200 person-rem for the 110 million people considered at risk. The site average individual dose commitment from all pathways ranged from a low of 5 /times/ 10/sup /minus/6/ mrem to a high of 0.02 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites

  13. Estimated radiation exposure of German commercial airline cabin crew in the years 1960-2003 modeled using dose registry data for 2004-2015.

    Science.gov (United States)

    Wollschläger, Daniel; Hammer, Gaël Paul; Schafft, Thomas; Dreger, Steffen; Blettner, Maria; Zeeb, Hajo

    2018-05-01

    Exposure to ionizing radiation of cosmic origin is an occupational risk factor in commercial aircrew. In a historic cohort of 26,774 German aircrew, radiation exposure was previously estimated only for cockpit crew using a job-exposure matrix (JEM). Here, a new method for retrospectively estimating cabin crew dose is developed. The German Federal Radiation Registry (SSR) documents individual monthly effective doses for all aircrew. SSR-provided doses on 12,941 aircrew from 2004 to 2015 were used to model cabin crew dose as a function of age, sex, job category, solar activity, and male pilots' dose; the mean annual effective dose was 2.25 mSv (range 0.01-6.39 mSv). In addition to an inverse association with solar activity, exposure followed age- and sex-dependent patterns related to individual career development and life phases. JEM-derived annual cockpit crew doses agreed with SSR-provided doses for 2004 (correlation 0.90, 0.40 mSv root mean squared error), while the estimated average annual effective dose for cabin crew had a prediction error of 0.16 mSv, equaling 7.2% of average annual dose. Past average annual cabin crew dose can be modeled by exploiting systematic external influences as well as individual behavioral determinants of radiation exposure, thereby enabling future dose-response analyses of the full aircrew cohort including measurement error information.

  14. Observational study of vaccine efficacy 24 years after the start of hepatitis B vaccination in two Gambian villages: no need for a booster dose.

    Directory of Open Access Journals (Sweden)

    Maimuna Mendy

    Full Text Available To determine the duration of protection from hepatitis B vaccine given in infancy and early childhood and asses risk factors for HBV infection and chronic infection.In 1984 infant HBV vaccination was started in two Gambian villages. Cross sectional serological surveys have been undertaken every 4 years to determine vaccine efficacy. In the current survey 84.6% of 1508 eligible participants aged 1-28 years were tested. A spouse study was conducted in females (aged 14 years and above and their male partners.Vaccine efficacy against chronic infection with hepatitis B virus was 95.1% (95% confidence interval 91.5% to 97.1%, which did not vary significantly between age groups or village. Efficacy against infection was 85.4% (82.7% to 87.7%, falling significantly with age. Concentrations of hepatitis B antibody fell exponentially with age varying according to peak response: 20 years after vaccination only 17.8% (95% CI 10.1-25.6 of persons with a low peak response (10-99 mIU/ml had detectable HBs antibody compared to 27% (21.9% to 32.2% of those with a high peak response (>999 mIU/ml. Time since vaccination and a low peak response were the strongest risk factors for HBV infections; males were more susceptible, marriage was not a significant risk for females. Hepatitis B DNA was not detected after infection, which tested soley core antibody positive. An undetectable peak antibody response of <10 mIU/ml and a mother who was hepatitis B e antigen positive were powerful risk factors for chronic infection.Adolescents and young adults vaccinated in infancy are at increased risk of hepatitis B infection, but not chronic infection. Married women were not at increased risk. There is no compelling evidence for the use of a booster dose of HBV vaccine in The Gambia.

  15. Brachytherapy source calibration, reviews, and consistency of 192Ir high-dose rate afterloading sources supplied over the period of 10 years: a retrospective analysis

    International Nuclear Information System (INIS)

    Nagappan, Balasubramanian; Kumar, Yogesh; Patel, Narayan P.; Dhull, Anil Kumar; Kaushal, Vivek

    2015-01-01

    Measurement and verification of strength of monomodal high-dose rate (mHDR) 192 Ir source supplied by the vendor is a major part of quality assurance program. Reference air kerma rate (RAKR) or air kerma strength (AKS) is the recommended quantity to specify the strength of gamma emitting brachytherapy sources. Physicist in our institution performed the source calibration as soon as each 192 Ir new source was loaded on the mHDR afterloading machine. The AKS accurately measured using a physikalisch technische werkstatten (PTW) re-entrant chamber-electrometer system in a scatter-free geometry was used to compute the air kerma rate (AKR) at one-meter distance in the air. To ensure accurate dose delivery to brachytherapy patients, measured AKS or RAKR should be entered correctly in both HDR treatment console station (TCS) as well as treatment planning system (TPS) associated with it. The clinical outcome mainly depends not only on the accuracy of the source strength measurement in the hospital but also on the correct source strength entered into both TCS and TPS software. A retrospective study on 22 mHDR V2 sources supplied by the vendor for the period of 10 years was taken up to access the accuracy of source strength supplied to the Radiotherapy department. The results are analyzed and reported. The accuracy in measured RAKR of all 22 sources supplied by vendor was well within the tolerance limits set by the national regulatory body and international recommendations. The deviations observed between measured RAKR versus manufacturer's quoted RAKR were in the range from -1.71% to +1.15%. In conclusion, the measured RAKR have good agreement with vendor quoted RAKR values. (author)

  16. Frailty, prefrailty and employment outcomes in Health and Employment After Fifty (HEAF) Study.

    Science.gov (United States)

    Palmer, Keith T; D'Angelo, Stefania; Harris, E Clare; Linaker, Cathy; Gale, Catharine R; Evandrou, Maria; Syddall, Holly; van Staa, Tjeerd; Cooper, Cyrus; Aihie Sayer, Avan; Coggon, David; Walker-Bone, Karen

    2017-07-01

    Demographic changes are requiring people to work longer. No previous studies, however, have focused on whether the 'frailty' phenotype (which predicts adverse events in the elderly) is associated with employment difficulties. To provide information, we assessed associations in the Health and Employment After Fifty Study, a population-based cohort of 50-65-year olds. Subjects, who were recruited from 24 English general practices, completed a baseline questionnaire on 'prefrailty' and 'frailty' (adapted Fried criteria) and several work outcomes, including health-related job loss (HRJL), prolonged sickness absence (>20 days vs less, past 12 months), having to cut down substantially at work and difficulty coping with work's demands. Associations were assessed using logistic regression and population attributable fractions (PAFs) were calculated. In all, 3.9% of 8095 respondents were classed as 'frail' and 31.6% as 'prefrail'. Three-quarters of the former were not in work, while 60% had left their last job on health grounds (OR for HRJL vs non-frail subjects, 30.0 (95% CI 23.0 to 39.2)). Among those in work, ORs for prolonged sickness absence, cutting down substantially at work and struggling with work's physical demands ranged from 10.7 to 17.2. The PAF for HRJL when any frailty marker was present was 51.8% and that for prolonged sickness absence was 32.5%. Associations were strongest with slow reported walking speed. Several associations were stronger in manual workers than in managers. Fried frailty symptoms are not uncommon in mid-life and are strongly linked with economically important adverse employment outcomes. Frailty could represent an important target for prevention. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. [Origin exploration of "the fifty-nine acupoints for febrile disease"].

    Science.gov (United States)

    Li, Guangyi

    2017-02-12

    Fifty-nine acupoints for febrile disease is recorded in Huangdi Neijing ( Huangdi's Internal Classics ). By analyzing the combination of these acupoints, the writer discovered the acupoint composition and detected their origins from Huangdi's Internal Classics , in which the terms biaoben, qijie and beishu are involved in the theoretic evidence. The writer thought the "fifty-nine acupoints for febrile disease" implied the self-evolution of some acupuncture school in ancient time, which was formed by absorbing the theoretic experiences of the other schools. It is necessary to analyze and interpret the other literatures besides Huangdi's Internal Classics and probably obtain the further reorganization on it.

  18. Quality control in pulsed dose rate brachytherapy; Controle de qualite en curietherapie de debit de dose pulse

    Energy Technology Data Exchange (ETDEWEB)

    Metayer, Y.; Brunaud, C.; Peiffert, D. [Centre Alexis-Vautrin, Unite de Radiophysique, 54 - Vandoeuvre-les-Nancy (France); Meyer, P. [Centre Paul-Strauss, 67 - Strasbourg (France)

    2009-07-15

    A prospective multicenter study (P.D.R.) was leaded on pulsed dose rate brachytherapy over 2 years (2005/2006) in 20 French centres, as part of a programme entitled (Support for the innovative and expensive techniques) S.t.i.c.-P.D.R. and supported by the French ministry of health. Eight hundred and fifty patients were treated for cervix carcinoma with 2D classic or 3D innovative brachytherapy (425 in each arm). The main objectives of this study were to assess the cost of P.D.R. brachytherapy with dose optimization compared to traditional treatments, and to evaluate the complications and local control. A joint programme of quality control was established by the physicists of the different centres, concerning the software treatment planning, the source replacement, the projector and the technical parameters of the course of patient treatment. This technical note lists these controls, and their frequency. (authors)

  19. Pattern of employment and associated factors in long-term lymphoma survivors 10 years after high-dose chemotherapy with autologous stem cell transplantation.

    Science.gov (United States)

    Kiserud, C E; Fagerli, U-M; Smeland, K B; Fluge, Ø; Bersvendsen, H; Kvaløy, S; Holte, H; Dahl, A A

    2016-05-01

    Background This study examined employment patterns and associated factors in lymphoma survivors treated with high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT) from diagnosis to a follow-up survey at a mean of 10 years after HDT-ASCT. Patients and methods All lymphoma survivors aged ≥18 years at HDT-ASCT in Norway from 1987 to 2008, and alive at the end of 2011 were eligible for this cross-sectional study performed in 2012/2013. Participants completed a mailed questionnaire. Job status was dichotomized as either employed (paid work) or not-employed (disability and retirement pension, on economic support, home-makers, or students). Results The response rate was 78%, and the sample (N = 312) contained 60% men. Mean age at HDT-ASCT was 44.3 and at survey 54.0 years. At diagnosis 85% of survivors were employed, 77% before and 77% after HDT-ASCT, and 58% at follow-up. Forty seven percent of the survivors were employed at all time points. The not-employed group at survey was significantly older and included significantly more females than the employed group. No significant between-group differences were observed for lymphoma-related variables. Fatigue, mental distress and type D personality were significantly higher among those not-employed, while quality of life was significantly lower compared to the employed group. Older age at survey, being female, work ability and presence of type D personality remained significantly related to being not-employed at survey in the multivariable analysis. Conclusions Our findings show that not-employed long-term survivors after HDT-ASCT for lymphoma have more comorbidity, cognitive problems and higher levels of anxiety/depression than employed survivors. These factors should be checked and eventually treated in order to improve work ability.

  20. Population dose commitments due to radioactive releases from Nuclear-Power-Plant Sites in 1979

    International Nuclear Information System (INIS)

    Baker, D.A.; Peloquin, R.A.

    1982-12-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1979. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each site. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each site is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitment from both liquid and airborne pathways ranged from a high of 1300 person-rem to a low of 0.0002 person-rem with an arithmetic mean of 38 person-rem. The total population dose for all sites was estimated at 1800 person-rem for the 94 million people considered at risk. The average individual dose commitment from all pathways on a site basis ranged from a low of 2 x 10 - 6 mrem to a high of 0.7 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites

  1. Population dose commitments due to radioactive releases from nuclear-power-plant sites in 1978

    International Nuclear Information System (INIS)

    Peloquin, R.A.; Schwab, J.D.; Baker, D.A.

    1982-06-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1978. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each site. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each site is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitment from both liquid and airborne pathways ranged from a high of 200 person-rem to a low of 0.0004 person-rem with an arithmetic mean of 14 person-rem. The total population dose for allsites was estimated at 660 person-rem for the 93 million people considered at risk. The average individual dose commitment from all pathways on a site basis ranged from a low of 3 x 10 -6 mrem to a high of 0.08 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites

  2. Fiction or not? Fifty Shades is associated with health risks in adolescent and young adult females.

    Science.gov (United States)

    Bonomi, Amy E; Nemeth, Julianna M; Altenburger, Lauren E; Anderson, Melissa L; Snyder, Anastasia; Dotto, Irma

    2014-09-01

    No prior study has empirically characterized the association between health risks and reading popular fiction depicting violence against women. Fifty Shades--a blockbuster fiction series--depicts pervasive violence against women, perpetuating a broader social narrative that normalizes these types of risks and behaviors in women's lives. The present study characterized the association between health risks in women who read and did not read Fifty Shades; while our cross-sectional study design precluded causal determinations, an empirical representation of the health risks in women consuming the problematic messages in Fifty Shades is made. Females ages 18 to 24 (n=715), who were enrolled in a large Midwestern university, completed a cross-sectional online survey about their health behaviors and Fifty Shades' readership. The analysis included 655 females (219 who read at least the first Fifty Shades novel and 436 who did not read any part of Fifty Shades). Age- and race-adjusted multivariable models characterized Fifty Shades' readers and nonreaders on intimate partner violence victimization (experiencing physical, sexual and psychological abuse, including cyber-abuse, at some point during their lifetime); binge drinking (consuming five or more alcoholic beverages on six or more days in the last month); sexual practices (having five or more intercourse partners and/or one or more anal sex partner during their lifetime); and using diet aids or fasting for 24 or more hours at some point during their lifetime. One-third of subjects read Fifty Shades (18.6%, or 122/655, read all three novels, and 14.8%, or 97/655, read at least the first novel but not all three). In age- and race-adjusted models, compared with nonreaders, females who read at least the first novel (but not all three) were more likely than nonreaders to have had, during their lifetime, a partner who shouted, yelled, or swore at them (relative risk [RR]=1.25) and who delivered unwanted calls/text messages

  3. Radiotherapy reference dose audit in the United Kingdom by the National Physical Laboratory: 20 years of consistency and improvements

    Directory of Open Access Journals (Sweden)

    Russell A.S. Thomas

    2017-07-01

    Conclusions: The introduction of the 2003 electron code of practice based on absorbed dose to water decreased the difference between absolute dose measurements by the centre and NPL. The use of a single photon code of practice over the period of measurements has contributed to a reduction in measurement variation. Within the clinical setting, on-site audit visits have been shown to identify areas of improvement for determining and implementing absolute dose calibrations.

  4. Committed effective dose from thoron daughters inhalation

    International Nuclear Information System (INIS)

    Campos, M.P.; Pecequilo, B.R.S.

    2000-01-01

    Mankind's interest in natural radiation exposure levels has increased over the past fifty years and it is now recognized that the most significant contributors to human irradiation by natural sources are the short-lived decay products of radon ( 222 Rn) and thoron ( 220 Rn). Despite the thoron short half-life of 55 s, effective dose from inhalation of thoron an its progeny ( 212 Pb and 212 Bi) must be considered, owing to the high thorium background in countries like Brazil, China and India, for example. The indoor committed effective dose was assessed by air sampling at the thorium purification plant and the nuclear materials storage site of the Instituto de Pesquisas Energeticas e Nucleares; Sao Paulo, Brazil. A total of 21 glass fiber filter samples was analyzed by high resolution gamma ray spectrometry in order to obtain the 212 Pb and 212 Bi activities. The equilibrium equivalent concentration (EEC) varied from 0.3 Bq/m 3 to 6.8 Bq/m 3 for the storage site air samples and from 9.9 Bq/m 3 to 249.8 Bq/m 3 for the thorium purification plant air samples. As retention studies indicate a biological half-life of a few hours inhaled thoron progeny in the human lungs, the main fraction of the potential alpha energy (PAEC) deposited is absorbed in the lungs, meaning negligible to the effective dose the contribution of the dose in other times. The committed effective dose due thoron progeny was performed by compartimental analysis following the ICRP 66 lung compartimental model and ICRP 67 lead compartimental model. The values obtained varied from 0.03 mSv/a to 0.67 mSv/a for the storage site air samples and from 0.12 mSv/a to 6.00 mSv/a for the thorium purification plant air samples. (author)

  5. Is the standard dose rate for de-contamination, 0.23 mc-Sv/hr, truly 1 mSv/year?

    International Nuclear Information System (INIS)

    Furuta, Sadaaki

    2014-01-01

    Examined is the validity of the standard dose rates in the title, which have been additionally defined by Ministry of the Environment (ME) to the measures of Fukushima Nuclear Power Plant Accident. The standard 0.23 mc-Sv/hr is the sum of natural ambient dose rate 0.04 mc-Sv/hr in average of Japan as measured with NaI scintillation surveymeter, plus additional accidental exposure dose 1 mSv/y, which is defined equivalent to 0.19 mc-Sv/hr. Here, the equation of addition 0.04+0.19 mc-Sv/hr is not exactly correct because the unit of each dose value has different means as follows. The natural dose is derived from the value 5.8 mc-R/hr (0.038 mc-Sv/hr, effective dose) of the average national natural dose data (2011) of Ministry of Education, Culture, Sports, Science and Technology. However, if the measurement is done with the surveymeter which practically gives 1 cm dose equivalent, the rate is calculated to be 0.06 mc-Sv/hr. When the Fukushima prefectural natural dose rate 6.4 mc-R/hr is employed, the calculation gives 0.07 mc-Sv/hr. ME defines the additional doses to be 0.19 mc-Sv/hr and 1 mSv/y, which are derived from the calculation: (0.19 mc-Sv/hr x 8 hr outdoor + 0.19 mc-Sv/hr x 0.4 indoor, shielded) x 365 d/y= 1 mSv/y. The dose is assumed to be measurable with the surveymeter (1 cm dose equivalent) and thereby calculation, if the source is mainly "1"3"4Cs and "1"3"7Cs, gives the effective dose of 0.32 mc-Sv/hr to be managed by the meter. As this, the effective dose unit and 1 cm equivalent dose unit are used for calculation of the administrative standard dose rate of 1 mSv/y, which should be recognized by both radiological experts and administration for the explanation to general public. (T.T.)

  6. Dose commitments due to radioactive releases from nuclear power plant sites in 1992. Volume 14

    International Nuclear Information System (INIS)

    Aaberg, R.L.; Baker, D.A.

    1996-03-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1992. Fifty-year dose commitments for a 1-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teenager, and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses, which are compared with 10 CFR Part 50, Appendix I, design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 3.7 person-rem to a low of 0.0015 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 0.66 person-rem. The total population dose for all sites was estimated at 47 person-rem for the 130-million people considered at risk. The individual dose commitments estimated for all sites were below the 10 CFR 50, Appendix I, design objectives

  7. Dose commitments due to radioactive releases from nuclear power plant sites in 1991. Volume 13

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.A. [Pacific Northwest Lab., Richland, WA (United States)

    1995-04-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1991. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teenager and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses which are compared with 10 CFR Part 50, Appendix 1 design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 22 person-rem to a low of 0.002 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 1.2 person-rem. The total population dose for all sites was estimated at 88 person-rem for the 130 million people considered at risk. The individual dose commitments estimated for all sites were below the Appendix 1 design objectives.

  8. Dose commitments due to radioactive releases from nuclear power plant sites in 1992. Volume 14

    Energy Technology Data Exchange (ETDEWEB)

    Aaberg, R.L.; Baker, D.A.

    1996-03-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1992. Fifty-year dose commitments for a 1-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teenager, and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses, which are compared with 10 CFR Part 50, Appendix I, design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 3.7 person-rem to a low of 0.0015 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 0.66 person-rem. The total population dose for all sites was estimated at 47 person-rem for the 130-million people considered at risk. The individual dose commitments estimated for all sites were below the 10 CFR 50, Appendix I, design objectives.

  9. Dose commitments due to radioactive releases from nuclear power plant sites in 1991. Volume 13

    International Nuclear Information System (INIS)

    Baker, D.A.

    1995-04-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1991. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teenager and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses which are compared with 10 CFR Part 50, Appendix 1 design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 22 person-rem to a low of 0.002 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 1.2 person-rem. The total population dose for all sites was estimated at 88 person-rem for the 130 million people considered at risk. The individual dose commitments estimated for all sites were below the Appendix 1 design objectives

  10. Dose commitments due to radioactive releases from nuclear power plant sites in 1989

    International Nuclear Information System (INIS)

    Baker, D.A.

    1993-02-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1989. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses which are compared with 10 CFR Part 50, Appendix I design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 14 person-rem to a low of 0.005 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 1.2 person-rem. The total population dose for all sites was estimated at 84 person-rem for the 140 million people considered at risk. The individual dose commitments estimated for all sites were below the Appendix I design objectives

  11. Dose commitments due to radioactive releases from nuclear power plant sites in 1989

    Energy Technology Data Exchange (ETDEWEB)

    Baker, D.A. (Pacific Northwest Lab., Richland, WA (United States))

    1993-02-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1989. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses which are compared with 10 CFR Part 50, Appendix I design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 14 person-rem to a low of 0.005 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 1.2 person-rem. The total population dose for all sites was estimated at 84 person-rem for the 140 million people considered at risk. The individual dose commitments estimated for all sites were below the Appendix I design objectives.

  12. Dose commitments due to radioactive releases from nuclear power plant sites in 1990: Volume 12

    International Nuclear Information System (INIS)

    Baker, D.A.

    1994-11-01

    Population and individual radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1990. Fifty-year dose commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 72 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is an estimate of individual doses which are compared with 10 CFR Part 50, Appendix 1 design objectives. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 15 person-rem to a low of 0.002 person-rem for the sites with plants in operation and producing power during the year. The arithmetic mean was 1.1 person-rem. The total population dose for all sites was estimated at 78 person-rem for the 130 million people considered at risk. The individual dose commitments estimated for all sites were below the Appendix 1 design objectives

  13. Fifty Shades a way readers put sex back in their lives

    DEFF Research Database (Denmark)

    Knudsen, Gry Høngsmark

    2014-01-01

    This is a guest blog from Gry Høngsmark Knudsen, a former student, who visited my “Women’s Economy” class this winter to report on her project about the reception of Fifty Shades of Grey. We all enjoyed her report, so I asked her to write a short blog for Double X Readers....

  14. Dose from radiological examinations

    International Nuclear Information System (INIS)

    Imamura, Keiko; Uji, Teruyuki; Sakuyama, Keiko; Fujikawa, Mitsuhiro; Fujii, Masamichi

    1976-01-01

    Relatively high gonad doses, several hundred to one thousand mR, have been observed in case of pelvis, hip-joint, coccyx, lower abdomen and lumber examination. Dose to the ovary is especially high in barium enema and I.V.P. examinations. About 12 per cent of the 4-ray examination are high-dose. The gonad dose is relatively high in examination of abdomen and lower extremities, in infants. The dose to the eyes is especially high, 1.0 to 2.5R per exposure, in temporal bone and nasal sinuses tomography. X-ray doses have been compared with dose limits recommended by ICRP and with the gonad dose from natural radiations. The gonad dose in lumbar examination, barium enema, I.V.P. etc. is as high as the maximum permissible dose per year recommended by ICRP. Several devices have been made for dose reduction in the daily examinations: (1) separating the radiation field from the gonad by one centimeter decreases the gonad dose about one-half. (2) using sensitive screens and films. In pelvimetry and in infant hip-joint examination, the most sensitive screen and film are used. In the I.V.P. examination of adult, use of MS screen in place of FS screen decreases the dose to one-third, in combination with careful setting of radiation field, (3) use of grid increases the dose about 50 percent and the lead rubber protection (0.1mm lead equivalent) decreases the gonad dose to one-thirtieth in the spinal column examination of infant, (4) A lead protector, 1mm thickness and 2.5cm in diameter, on the eyes decreases the dose to about one-eighth in the face and nead examinations. These simple and effective methods for dose reduction. Should be carried out in as many examinations as possible in addition to observing dose limits recommended by ICRP. (Evans, J.)

  15. Prostate-Specific Antigen at 4 to 5 Years After Low-Dose-Rate Prostate Brachytherapy Is a Strong Predictor of Disease-Free Survival

    International Nuclear Information System (INIS)

    Lo, Andrea C.; Morris, W. James; Lapointe, Vincent; Hamm, Jeremy; Keyes, Mira; Pickles, Tom; McKenzie, Michael; Spadinger, Ingrid

    2014-01-01

    Purpose: To determine (1) the prognostic utility of prostate-specific antigen (PSA) concentration at 45 to 60 months (48mPSA) after low-dose-rate prostate brachytherapy (LDR-PB); (2) the predictors of 48mPSA; and (3) the prognostic utility of directional trends between PSA levels at 24, 36, and 48 months after LDR-PB. Methods and Materials: Between 1998 and 2008, 2223 patients with low- and intermediate-risk prostate cancer received LDR-PB monotherapy. A cohort of 1434 of these patients was identified with a documented 48mPSA and no evidence of disease relapse prior to the 48mPSA. In addition, a subset of this cohort (n=585) was identified with ≥72 months of follow-up and documented PSA values at both 24 and 36 months after implantation. Results: Median follow-up time was 76 months. Eight-year Kaplan-Meier disease-free survival (DFS) rates were 100% vs 73.4% for patients with 48mPSA ≤0.2 vs those with >0.2 ng/mL; 99.1% versus 53.8% for a 48mPSA threshold of ≤0.4 versus >0.4 ng/mL, respectively; and 97.3% versus 0% for a threshold of ≤1.0 versus >1.0 ng/mL, respectively. On multivariate analysis, the only factor predictive of DFS was 48mPSA (P 0.2 ng/mL) between 24 and 36 months, 24 patients had a rise between 36 and 48 months, and 11 patients had rises over both intervals. Failure rates in these patients were 52%, 79%, and 100%, respectively. On multivariate analysis, initial PSA, androgen deprivation therapy, and dose to 90% of the prostate significantly correlated with 48mPSA but together accounted for only ∼5% of its total variance. Conclusions: The 48mPSA after LDR-PB is highly predictive of long-term DFS. Patients with 48mPSA ≤0.4 ng/mL had a 1.0 ng/mL relapsed. Consecutive PSA rises of >0.2 ng/mL from 24 to 36 months and from 36 to 48 months were also highly predictive of subsequent failure

  16. Total body irradiation (TBI) in pediatric patients. A single-center experience after 30 years of low-dose rate irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Linsenmeier, Claudia; Thoennessen, Daniel; Negretti, Laura; Streller, Tino; Luetolf, Urs Martin [University Hospital Zurich (Switzerland). Dept. of Radiation-Oncology; Bourquin, Jean-Pierre [University Children' s Hospital Zurich (Switzerland). Dept. of Hemato-Oncology; Oertel, Susanne [University Hospital Zurich (Switzerland). Dept. of Radiation-Oncology; Heidelberg Univ. (Germany). Dept. of Radiation Oncology

    2010-11-15

    To retrospectively analyze patient characteristics, treatment, and treatment outcome of pediatric patients with hematologic diseases treated with total body irradiation (TBI) between 1978 and 2006. 32 pediatric patients were referred to the Department of Radiation-Oncology at the University of Zurich for TBI. Records of regular follow-up of 28 patients were available for review. Patient characteristics as well as treatment outcome regarding local control and overall survival were assessed. A total of 18 patients suffered from acute lymphoblastic leukemia (ALL), 5 from acute and 2 from chronic myelogenous leukemia, 1 from non-Hodgkin lymphoma, and 2 from anaplastic anemia. The cohort consisted of 15 patients referred after first remission and 13 patients with relapsed leukemia. Mean follow-up was 34 months (2-196 months) with 15 patients alive at the time of last follow-up. Eight patients died of recurrent disease, 1 of graft vs. host reaction, 2 of sepsis, and 2 patients died of a secondary malignancy. The 5-year overall survival rate (OS) was 60%. Overall survival was significantly inferior in patients treated after relapse compared to those treated for newly diagnosed leukemia (24% versus 74%; p=0.004). At the time of last follow-up, 11 patients survived for more than 36 months following TBI. Late effects (RTOG {>=}3) were pneumonitis in 1 patient, chronic bronchitis in 1 patient, cardiomyopathy in 2 patients, severe cataractogenesis in 1 patient (48 months after TBI with 10 Gy in a single dose) and secondary malignancies in 2 patients (36 and 190 months after TBI). Growth disturbances were observed in all patients treated prepubertally. In 2 patients with identical twins treated at ages 2 and 7, a loss of 8% in final height of the treated twin was observed. As severe late sequelae after TBI, we observed 2 secondary malignancies in 11 patients who survived in excess of 36 months. However, long-term morbidity is moderate following treatment with the fractionated

  17. Radiation dose associated with CT-guided drain placement for pediatric patients

    International Nuclear Information System (INIS)

    Schwartz, Cody J.; Isaacson, Ari J.; Fordham, Lynn Ansley; Ivanovic, Marija; Dixon, Robert G.; Taylor, J.B.

    2017-01-01

    To date, there are limited radiation dose data on CT-guided procedures in pediatric patients. Our goal was to quantify the radiation dose associated with pediatric CT-guided drain placement and follow-up drain evaluations in order to estimate effective dose. We searched the electronic medical record and picture archiving and communication system (PACS) to identify all pediatric (<18 years old) CT-guided drain placements performed between January 2008 and December 2013 at our institution. We compiled patient data and radiation dose information from CT-guided drain placements as well as pre-procedural diagnostic CTs and post-procedural follow-up fluoroscopic abscess catheter injections (sinograms). Then we converted dose-length product, fluoroscopy time and number of acquisitions to effective doses using Monte Carlo simulations and age-appropriate conversion factors based on annual quality-control testing. Fifty-two drainages were identified with mean patient age of 11.0 years (5 weeks to 17 years). Most children had diagnoses of appendicitis (n=23) or inflammatory bowel disease (n=11). Forty-seven patients had diagnostic CTs, with a mean effective dose of 7.3 mSv (range 1.1-25.5 mSv). Drains remained in place for an average of 16.9 days (range 0-75 days), with an average of 0.9 (0-5) sinograms per patient in follow-up. The mean effective dose for all drainages and follow-up exams was 5.3 mSv (0.7-17.1) and 62% (32/52) of the children had effective doses less than 5 mSv. The majority of pediatric patients who have undergone CT-guided drain placements at our institution have received total radiation doses on par with diagnostic ranges. This information could be useful when describing the dose of radiation to parents and providers when CT-guided drain placement is necessary. (orig.)

  18. Radiation dose associated with CT-guided drain placement for pediatric patients

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, Cody J.; Isaacson, Ari J.; Fordham, Lynn Ansley; Ivanovic, Marija; Dixon, Robert G. [University of North Carolina at Chapel Hill, Department of Radiology, UNC Health Care, Chapel Hill, NC (United States); Taylor, J.B. [University of North Carolina at Chapel Hill, Environment, Health and Safety, Chapel Hill, NC (United States)

    2017-05-15

    To date, there are limited radiation dose data on CT-guided procedures in pediatric patients. Our goal was to quantify the radiation dose associated with pediatric CT-guided drain placement and follow-up drain evaluations in order to estimate effective dose. We searched the electronic medical record and picture archiving and communication system (PACS) to identify all pediatric (<18 years old) CT-guided drain placements performed between January 2008 and December 2013 at our institution. We compiled patient data and radiation dose information from CT-guided drain placements as well as pre-procedural diagnostic CTs and post-procedural follow-up fluoroscopic abscess catheter injections (sinograms). Then we converted dose-length product, fluoroscopy time and number of acquisitions to effective doses using Monte Carlo simulations and age-appropriate conversion factors based on annual quality-control testing. Fifty-two drainages were identified with mean patient age of 11.0 years (5 weeks to 17 years). Most children had diagnoses of appendicitis (n=23) or inflammatory bowel disease (n=11). Forty-seven patients had diagnostic CTs, with a mean effective dose of 7.3 mSv (range 1.1-25.5 mSv). Drains remained in place for an average of 16.9 days (range 0-75 days), with an average of 0.9 (0-5) sinograms per patient in follow-up. The mean effective dose for all drainages and follow-up exams was 5.3 mSv (0.7-17.1) and 62% (32/52) of the children had effective doses less than 5 mSv. The majority of pediatric patients who have undergone CT-guided drain placements at our institution have received total radiation doses on par with diagnostic ranges. This information could be useful when describing the dose of radiation to parents and providers when CT-guided drain placement is necessary. (orig.)

  19. Comparison of single-grain and small-aliquot OSL dose estimates in < 3000 years old river sediments from South India

    DEFF Research Database (Denmark)

    Thomas, P.J.; Jain, M.; Juyal, N.

    2005-01-01

    We report on OSL dose distributions derived from small-aliquot and single grains of quartz in young fluvial sediments sampled from the Penner River basin, South India. The single-grain dose distributions suggest that 13 out of 19 samples were well bleached. In many well-bleached samples, there wa......We report on OSL dose distributions derived from small-aliquot and single grains of quartz in young fluvial sediments sampled from the Penner River basin, South India. The single-grain dose distributions suggest that 13 out of 19 samples were well bleached. In many well-bleached samples......, there was an underestimation in the single-aliquot dose estimates as compared to those from the single grain-the difference between average dose estimates determined by the two methods ranged from similar to 1% to 31%. Such a dose underestimation was not detectable in poorly bleached samples. Various possible reasons...... perhaps be one of the reasons; this may occur because the stimulation wavelength affects the proportion of the medium and slow components in the initial signal. (c) 2004 Elsevier Ltd. All rights reserved....

  20. Assessment of coverage levels of single dose measles vaccine

    International Nuclear Information System (INIS)

    Tariq, P.

    2003-01-01

    Objective: To study the consequences of low coverage levels of a single dose of measles vaccine. Results: mean age observed in measles cases was 2 years and 8 months with a range from 3 months to 8 years. Maximum number of cases reported were <1 year of age (n=22,32%). Fifty percent of cases were seen among vaccinated children. Seventy-five percent (n=51) had history of contact with a measles case. Pneumonia was the commonest complication followed by acute gastroenteritis, encephalitis, febrile convulsions, oral ulcers, oral thrush, eye changes of vitamin-A deficiency and pulmonary tuberculosis (T.B.) in descending order of frequency. Fifty four cases were successfully treated for complications of measles and discharged. Nine cases left against medical advice. Five patients died all of them had encephalitis either alone (n=1) or in combination with pneumonia and acute gastroenteritis (n=4). Conclusion: There is a dire need to increase the immunization coverage to reduce the rate of vaccine failure and achieve effective control of measles.(author)

  1. Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes

    DEFF Research Database (Denmark)

    Dirksen, Carsten; Jacobsen, Siv H; Bojsen-Møller, Kirstine N

    2013-01-01

    Experience with Roux-en-Y gastric bypass in patients with type 1 diabetes is very limited, despite an increasing prevalence of obesity also in this population. We describe changes in anthropometric measures, insulin dose, HbA1c, blood pressure, lipid status, and metabolic response to a liquid mixed...... meal throughout the first year after RYGB in an obese patient with type 1 diabetes. No change in HbA1c was observed, but a 48% reduction in weight-adjusted insulin dose and improvements in cardiovascular risk factors was seen 1 year after surgery. Exaggerated secretions of anorexigenic gut hormones...

  2. Low-dose biplanar skeletal survey versus digital skeletal survey in multiple myeloma

    International Nuclear Information System (INIS)

    Boutry, Nathalie; Dutouquet, Bastien; Cotten, Anne; Leleu, Xavier; Vieillard, Marie-Helene; Duhamel, Alain

    2013-01-01

    To evaluate the low-dose biplanar (LDB) skeletal survey (SS) for the assessment of focal bone involvement in patients with multiple myeloma (MM) as compared with digital SS and to compare the two techniques in terms of image quality, patient comfort and radiation exposure. Fifty-six consecutive patients with newly diagnosed or first relapsed MM underwent LDB and digital SS on the same day. These were assessed by two radiologists for the detection of focal bone lesions. In the case of discordance, whole-body MR imaging was performed. Image quality, patient comfort and radiation dose were also assessed. Fifty-six patients (M:30, F:26, mean age, 62 years) with newly diagnosed (n = 21) or first relapse MM (n = 35) were enrolled. A total of 473 bone lesions in 46 patients (82 %) were detected. Out of that total, digital SS detected significantly more lesions than LDB SS (451 [95.35 %] versus 467 [98.73 %]), especially in osteopenic and obese patients. Overall patient satisfaction was greater with LDB SS (48.6 %) compared with digital SS (2.7 %). The radiation dose was significantly reduced (by a factor of 7.8) with the LDB X-ray device. Low-dose biplanar skeletal surveys cannot replace digital SS in all patients suffering from multiple myeloma. (orig.)

  3. Low-dose biplanar skeletal survey versus digital skeletal survey in multiple myeloma

    Energy Technology Data Exchange (ETDEWEB)

    Boutry, Nathalie [University Hospital of Jeanne de Flandre and University of Lille 2, Departments of Pediatric and Musculoskeletal Imaging, Lille (France); University Hospital of Jeanne de Flandre and University of Lille 2, Department of Pediatric Imaging, Lille (France); Hopital Jeanne de Flandre, Service de Radiopediatrie, Lille (France); Dutouquet, Bastien; Cotten, Anne [University Hospital of Roger Salengro and University of Lille 2, Department of Musculoskeletal Imaging, Lille (France); Leleu, Xavier [University Hospital of Claude Huriez and University of Lille 2, Clinical Hematology Department, Lille (France); Vieillard, Marie-Helene [University Hospital of Roger Salengro and University of Lille 2, Rheumatology Department, Lille (France); Duhamel, Alain [University of Lille 2, Department of Medical Statistics, Lille (France)

    2013-08-15

    To evaluate the low-dose biplanar (LDB) skeletal survey (SS) for the assessment of focal bone involvement in patients with multiple myeloma (MM) as compared with digital SS and to compare the two techniques in terms of image quality, patient comfort and radiation exposure. Fifty-six consecutive patients with newly diagnosed or first relapsed MM underwent LDB and digital SS on the same day. These were assessed by two radiologists for the detection of focal bone lesions. In the case of discordance, whole-body MR imaging was performed. Image quality, patient comfort and radiation dose were also assessed. Fifty-six patients (M:30, F:26, mean age, 62 years) with newly diagnosed (n = 21) or first relapse MM (n = 35) were enrolled. A total of 473 bone lesions in 46 patients (82 %) were detected. Out of that total, digital SS detected significantly more lesions than LDB SS (451 [95.35 %] versus 467 [98.73 %]), especially in osteopenic and obese patients. Overall patient satisfaction was greater with LDB SS (48.6 %) compared with digital SS (2.7 %). The radiation dose was significantly reduced (by a factor of 7.8) with the LDB X-ray device. Low-dose biplanar skeletal surveys cannot replace digital SS in all patients suffering from multiple myeloma. (orig.)

  4. Young Women's Perceptions of the Relationship in Fifty Shades of Grey.

    Science.gov (United States)

    Bonomi, Amy E; Nichols, Emily M; Carotta, Christin L; Kiuchi, Yuya; Perry, Samantha

    2016-02-01

    Millions of women are interacting with Fifty Shades of Grey-a best-selling novel and film. Yet, to date, no social science study has been undertaken to examine women's perceptions of the Fifty Shades relationship narrative in its film adaptation-what they deem appealing, what they deem unappealing, and what they would welcome or resist in their own relationship. In the present study, we used focus groups to examine women's perceptions of the relationship patterns in the Fifty Shades of Grey film. Focus groups were conducted with 35 young adult women (randomly sampled from the registrar's office of a large Midwestern university) immediately after watching the Fifty Shades film with the study team at a local theater within two days of the film's release. Seven semistructured questions concentrating on reactions to the relationship patterns between Christian Grey and Anastasia Steele depicted in the Fifty Shades film were asked, including general reactions, appealing and unappealing characteristics, romantic and dangerous elements, and aspects that participants would tolerate (or not tolerate) in their own relationships. While participants assessed parts of the relationship between Christian and Anastasia as exciting and romantic, they consistently indicated an unappealing lack of health in the relationship. Participants expressed grave concerns over Christian's stalking, controlling, manipulative, and emotionally abusive behavior, anger in sexual interactions, and neglect of Anastasia's needs. At the same time, they sympathized with and rationalized Christian's behaviors as a function of his personality, needs, and abilities. A small contingent implicated Anastasia in the unhealthy relationship process, whereas a broader majority of participants highlighted the challenges with trying to "speak up" in an unhealthy relationship like Christian and Anastasia's. When asked where participants would draw the line in their own relationship, participants indicated they would

  5. Population dose commitments due to radioactive releases from nuclear power plant sites in 1980

    International Nuclear Information System (INIS)

    Baker, D.A.; Peloquin, R.A.

    1983-08-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1980. In addition doses derived from the shutdown reactors at the Three Mile Island site were included. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each site. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each site is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitment from both liquid and airborne pathways ranged from a high of 40 person-rem to a low of 0.02 person-rem with an arithmetic mean of 4 person-rem. The total population dose for all sites was estimated at 180 person-rem for the 96 million people considered at risk

  6. Comparison of single-grain and small-aliquot OSL dose estimates in <3000 years old river sediments from South India

    International Nuclear Information System (INIS)

    Thomas, P.J.; Jain, M.; Juyal, N.; Singhvi, A.K.

    2005-01-01

    We report on OSL dose distributions derived from small-aliquot and single grains of quartz in young fluvial sediments sampled from the Penner River basin, South India. The single-grain dose distributions suggest that 13 out of 19 samples were well bleached. In many well-bleached samples, there was an underestimation in the single-aliquot dose estimates as compared to those from the single grain-the difference between average dose estimates determined by the two methods ranged from ∼1% to 31%. Such a dose underestimation was not detectable in poorly bleached samples. Various possible reasons for the discrepancy between single-grain and small-aliquot dose estimates are discussed. Although there is no satisfactory explanation for this discrepancy, we speculate that the difference in the stimulation wavelengths, 470+/-30nm in the case of single-aliquot and 532nm in the case of single grains, could perhaps be one of the reasons; this may occur because the stimulation wavelength affects the proportion of the medium and slow components in the initial signal

  7. Women in Management - A Movement from the Fifties to the New Millenium

    OpenAIRE

    Parikh Indira J; Engineer Mahrukh

    2002-01-01

    "Women in Management - A Movement from the Fifties to the New Millennium", views the evolution and changes that have occurred from the 1950s onwards and looks at new opportunities for women managers in the new millennium. Women in Management are coming of age. The transformation of the Indian woman from an enigmatic figure, covered in meters of fabric, to todays educated, successful and accomplished professional has not been without great personal sacrifices. These are women who have broken t...

  8. Statement to the fifty-fifth session of the United Nations General Assembly

    International Nuclear Information System (INIS)

    ElBaradei, M.

    2000-01-01

    In his statement to the fifty-fifth session of the United Nations General Assembly, the Director General of the IAEA briefly presented the three fundamental functions of the IAEA, namely: its role as a catalyst for the development and transfer of peaceful nuclear technologies, the efforts to prevent the proliferation of nuclear weapons and move towards nuclear disarmament, and the work to build and maintain a global nuclear safety regime

  9. Age-related changes in the macula. A histopathological study of fifty Indian donor eyes

    OpenAIRE

    Biswas Jyotirmay; Raman Rajiv

    2002-01-01

    PURPOSE: Age-related macular degeneration (ARMD) is clinically less common in India compared to the West. Therefore, clinicians are unfamiliar with histopathologic evidence of age-related macular changes in the Indian population. METHODS: Fifty consecutive human donor eyes removed for corneal grafting were studied for gross, microscopic and histochemical features of age-related changes in the macula in the Indian population. A horizontal block was cut from the globe including the optic disc, ...

  10. Population dose commitments due to radioactive releases from nuclear power plant sites in 1983

    International Nuclear Information System (INIS)

    Baker, D.A.; Peloquin, R.A.

    1987-04-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1983. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 52 sites. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each of the sites is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 45 person-rem to a low of 0.002 person-rem for the sites with plants operating throughout the year with an arithmetic mean of 3 person-rem. The total population dose for all sites was estimated at 170 person-rem for the 100 million people considered at risk

  11. Extreme Markup: The Fifty US Hospitals With The Highest Charge-To-Cost Ratios.

    Science.gov (United States)

    Bai, Ge; Anderson, Gerard F

    2015-06-01

    Using Medicare cost reports, we examined the fifty US hospitals with the highest charge-to-cost ratios in 2012. These hospitals have markups (ratios of charges over Medicare-allowable costs) approximately ten times their Medicare-allowable costs compared to a national average of 3.4 and a mode of 2.4. Analysis of the fifty hospitals showed that forty-nine are for profit (98 percent), forty-six are owned by for-profit hospital systems (92 percent), and twenty (40 percent) operate in Florida. One for-profit hospital system owns half of these fifty hospitals. While most public and private health insurers do not use hospital charges to set their payment rates, uninsured patients are commonly asked to pay the full charges, and out-of-network patients and casualty and workers' compensation insurers are often expected to pay a large portion of the full charges. Because it is difficult for patients to compare prices, market forces fail to constrain hospital charges. Federal and state governments may want to consider limitations on the charge-to-cost ratio, some form of all-payer rate setting, or mandated price disclosure to regulate hospital markups. Project HOPE—The People-to-People Health Foundation, Inc.

  12. External effective radiation dose to workers in the restricted area of the Fukushima Daiichi Nuclear Power Plant during the third year after the Great East Japan Earthquake

    International Nuclear Information System (INIS)

    Sakumi, Akira; Miyagawa, Ryu; Tamari, Yuki; Nawa, Kanabu; Sakura, Osamu; Nakagawa, Keiichi

    2016-01-01

    Since the Great East Japan Earthquake on 11 March 2011, Iitate Village has continued to be classified as a deliberate evacuation area, in which residents are estimated to receive an annual additional effective radiation dose of >20 mSv. Some companies still operate in Iitate Village, with a special permit from the Cabinet Office Team in Charge of Assisting the Lives of Disaster Victims. In this study, we measured the annual effective radiation dose to workers in Iitate Village from 15 January to 13 December 2013. The workers stayed in Iitate for 10 h and left the village for the remaining 14 h each working day. They worked for 5 days each week in Iitate Village, but stayed outside of the village for the remaining 2 days each week. We found that the effective radiation dose of 70% of the workers was <2 mSv, including natural radiation; the maximum dose was 3.6 mSv. We estimated the potential annual additional effective radiation dose if people returned full-time to Iitate. Our analysis supports the plan for people to return to their home village at the end of 2017

  13. Long-term outcomes after disease activity-guided dose reduction of TNF inhibition in rheumatoid arthritis: 3-year data of the DRESS study - a randomised controlled pragmatic non-inferiority strategy trial

    NARCIS (Netherlands)

    Bouman, Chantal Am; van Herwaarden, Noortje; van den Hoogen, Frank Hj; Fransen, Jaap; van Vollenhoven, Ronald F.; Bijlsma, Johannes Wj; Maas, Aatke van der; den Broeder, Alfons A.

    2017-01-01

    Tumour necrosis factor inhibitors (TNFi) are effective in rheumatoid arthritis (RA), but disadvantages include adverse events (AEs) and high costs. This can be improved by disease activity-guided dose reduction (DR). We aimed to assess long-term outcomes of TNFi DR in RA by using 3-year data from

  14. Long-term outcomes after disease activity-guided dose reduction of TNF inhibition in rheumatoid arthritis: 3-year data of the DRESS study - a randomised controlled pragmatic non-inferiority strategy trial

    NARCIS (Netherlands)

    Bouman, C.A.M.; Herwaarden, N. van; Hoogen, F.H.J. van den; Fransen, J.; Vollenhoven, R.F. van; Bijlsma, J.W.; Maas, A.V.; Broeder, A.A. den

    2017-01-01

    OBJECTIVE: Tumour necrosis factor inhibitors (TNFi) are effective in rheumatoid arthritis (RA), but disadvantages include adverse events (AEs) and high costs. This can be improved by disease activity-guided dose reduction (DR). We aimed to assess long-term outcomes of TNFi DR in RA by using 3-year

  15. Population dose commitments due to radioactive releases from nuclear power plant sites in 1988

    International Nuclear Information System (INIS)

    Baker, D.A.

    1992-01-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1988. Fifty-year commitments for a one-year exposure from both liquid and atmospheric releases were calculated for four population groups (infant, child, teen-ager and adult) residing between 2 and 80 km from each of 71 reactor sites. This report tabulates the results of these calculations, showing the dose commitments for both water and airborne pathways for each age group and organ. Also included for each of the sites is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total collective dose commitments (from both liquid and airborne pathways) for each site ranged from a high of 16 person-rem to a low of 0.0011 person-rem for the sites with plants operating throughout the year with an arithmetic mean of 1.1 person-rem. The total population dose for all sites was estimated at 75 person-rem for the 150 million people considered at risk. The site average individual dose commitment from all pathways ranged from a low of 3 x 10 -7 mrem to a high of 0.02 mrem. No attempt was made in this study to determine the maximum dose commitment received by any one individual from the radionuclides released at any of the sites. However, licensee calculation of doses to the maximally exposed individual at some sites indicated values of up to approximately 100 times average individual doses (on the order of a few millirem per year)

  16. The results of randomized controlled trial of low-dose radiation for wet-type age-related macular degeneration on a 1 year term basis

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-06-01

    Evaluation of low dose radiation therapy to the wet-type age-related macular degeneration (AMD) located at the fovea centralis. Patients were irradiated with 10 fractions of 2 Gy external beam or just observed. Between the treated (39) and untreated (31) cases, there was no significant difference in gender, age, initial visual acuity, or size of the neovascular membrane. With the follow-up of 12 months, the visual acuity was significantly well preserved and the size of the neovascular membrane was decreased. These results indicate that low dose irradiation is effective for the wet-type AMD of the stage we treated in the present study. (author)

  17. Safety and immune response to a challenge dose of hepatitis B vaccine in healthy children primed 10years earlier with hexavalent vaccines in a 3, 5, 11-month schedule: An open-label, controlled, multicentre trial in Italy.

    Science.gov (United States)

    Zanetti, Alessandro; Desole, Maria Giuseppina; Romanò, Luisa; d'Alessandro, Antonio; Conversano, Michele; Ferrera, Giuseppe; Panico, Maria Grazia; Tomasi, Alberto; Zoppi, Giorgio; Zuliani, Massimo; Thomas, Stéphane; Soubeyrand, Benoît; Eymin, Cécile; Lockhart, Stephen

    2017-07-13

    The strategy of vaccinating infants to prevent hepatitis B virus infection in adolescence or adulthood requires durable immunity. This study investigated responses to a challenge dose of monovalent hepatitis B vaccine in children primed with three doses of either Hexavac® or Infanrix hexa® 10years earlier during infancy. This open-label, controlled, multicentre study conducted in Italy, enrolled 751 healthy pre-adolescents (aged 11-13years) who were given either Hexavac (n=409) or Infanrix hexa (n=342) at 3, 5 and 11months of life. All participants received a challenge dose of a monovalent hepatitis B vaccine (HBVaxPro® 5µg). The concentrations of antibodies to hepatitis B surface antigen (anti-HBs) were measured before and 1month after the challenge dose. The analysis was descriptive and no formal hypothesis was tested. One month post-challenge, 331 participants in the Hexavac cohort [83.6%, 95% CI: 79.6; 87.1] and 324 in the Infanrix hexa cohort [96.4%, 95% CI: 93.8; 98.1] had anti-HBs concentrations ≥10mIU/mL. Before the challenge dose, an anti-HBs concentration of ≥10mIU/mL was found in 94 children in the Hexavac cohort [23.9%, 95% CI: 19.7; 28.4] and in 232 children in the Infanrix hexa cohort [69%, 95% CI: 63.8; 74.0]. Among children with a pre-challenge anti-HBs concentration of children (>80%) at least 10years after a two-dose primary and booster vaccination schedule with a hexavalent vaccine (Hexavac or Infanrix hexa). EudraCT Number: 2013-001602-28; clinicaltrials.gov: NCT02012998. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Testicular dose and hormonal changes after radiotherapy of rectal cancer

    International Nuclear Information System (INIS)

    Hermann, Robert M.; Henkel, Karsten; Christiansen, Hans; Vorwerk, Hilke; Hille, Andrea; Hess, Clemens F.; Schmidberger, Heinz

    2005-01-01

    Background and purpose: To measure the dose received by the testicles during radiotherapy for rectal cancer and to determine the contribution of each field of the pelvic box and the relevance for hormonal status. Materials and methods: In 11 patients (mean age 55.2 years) testicular doses were measured with an ionisation chamber between 7 and 10 times during the course of pelvic radiotherapy (50 Gy) for rectal carcinoma. Before and several months after radiotherapy luteinizing hormone, follicle stimulating hormone and total testosterone serum levels were determined. Results: The mean cumulative radiation exposure to the testicles was 3.56 Gy (0.7-8.4 Gy; 7.1% of the prescribed dose). Seventy-three percent received more than 2 Gy to the testicles. Fifty-eight percent of the measured dose was contributed by the p.a. field, 30% by the a.p. field and 12% by the lateral fields. Mean LH and FSH levels were significantly increased after therapy (350%/185% of the pre-treatment values), testosterone levels decreased to 78%. No correlation could be found between changes of hormones and doses to the testis, probably due to the low number of evaluated patients. Conclusions: Radiotherapy of rectal carcinoma causes significant damage to the testis, as shown by increased levels of gonadotropins after radiotherapy. Most of the gonadal dose is delivered by the p.a. field, due to the divergence of the p.a. beam towards the testicles. The reduction in testosterone level may be of clinical concern. Patients who will receive radiotherapy for rectal carcinoma must be instructed about a high risk of permanent infertility, and the risk of endocrine failure (hypogonadism). Larger studies are needed to establish the correlation between testicular radiation dose and hormonal changes in this group of patients

  19. Paediatric dose display

    International Nuclear Information System (INIS)

    Griffin, D.W.; Derges, S.; Hesslewood, S.

    1984-01-01

    A compact, inexpensive unit, based on an 8085 microprocessor, has been designed for calculating doses of intravenous radioactive injections for children. It has been used successfully for over a year. The dose is calculated from the body surface area and the result displayed in MBq. The operator can obtain the required dose on a twelve character alphanumeric display by entering the age of the patient and the adult dose using a hexadecimal keyboard. Circuit description, memory map and input/output, and firmware are dealt with. (U.K.)

  20. Population dose commitments due to radioactive releases from nuclear power plant sites in 1981. Volume 3

    International Nuclear Information System (INIS)

    Baker, D.A.; Peloquin, R.A.

    1985-01-01

    Population radiation dose commitments have been estimated from reported radionuclide releases from commercial power reactors operating during 1981. Fifty-year dose commitments from a one-year exposure were calculated from both liquid and atmospheric releases for four population groups (infant, child, teenager and adult) residing between 2 and 80 km from each site. This report tabulates the results of these calculations, showing the dose commitments for both liquid and airborne pathways for each age group and organ. Also included for each site is a histogram showing the fraction of the total population within 2 to 80 km around each site receiving various average dose commitments from the airborne pathways. The total dose commitment from both liquid and airborne pathways from 48 sites ranged from a high of 20 person-rem to a low of 0.008 person-rem with an arithmetic mean of 3 person-rem. The total population dose for all sites was estimated at 160 person-rem for the 98 million people considered at risk