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Sample records for fibromatosis rf tumor

  1. Superficial Fibromatosis Mimicking Glomus Tumor of the Second Toe.

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    Jo, Hyang Jeong; Chae, Soo Uk; Kim, Gang Deuk; Kim, Yeung Jin; Choi, Deok Hwa; Park, Jae In

    2015-09-01

    Various types of tumor can occur in the subungual space, including glomus tumors, subungual exostosis, hemangioma, epidermal cysts, and malignant tumors. While fibromatosis can occur at various sites throughout the body, it is very rarely seen in the toe. Here, we are the first to report a case of superficial fibromatosis mimicking a glomus tumor in the subungual space of the second toe. The presentation of this condition shows the possibility of encountering uncommon superficial fibromatosis in the distal phalanx of the toe, and suggests that superficial fibromatosis should be included in the differential diagnosis of a glomus tumor in the toe.

  2. Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells.

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    Wu, Colleen; Amini-Nik, Saeid; Nik-Amini, Saied; Nadesan, Puviindran; Stanford, William L; Alman, Benjamin A

    2010-10-01

    The cellular origins from which most tumors arise are poorly defined, especially in mesenchymal neoplasms. Aggressive fibromatosis, also known as desmoid tumor, is a locally invasive soft tissue tumor that has mesenchymal characteristics. We found that aggressive fibromatosis tumors express genes and cell surface markers characteristic of mesenchymal stem cells (MSC). In mice that are genetically predisposed to develop aggressive fibromatosis tumors (Apc(wt/1638N)), we found that the number of tumors formed was proportional to the number of MSCs present. Sca-1(-/-) mice, which develop fewer MSCs, were crossed with Apc(wt/1638N) mice. Doubly mutant mice deficient in Sca-1 developed substantially fewer aggressive fibromatosis tumors than wild-type (WT) littermates, but Sca-1 deficiency had no effect on the formation of epithelial-derived intestinal polyps. MSCs isolated from Apc(wt/1638N) mice (or mice expressing a stabilized form of β-catenin) induced aberrant cellular growth reminiscent of aggressive fibromatosis tumors after engraftment to immunocompromised mice, but WT cells and mature fibroblasts from the same animals did not. Taken together, our findings indicate that aggressive fibromatosis is derived from MSCs, and that β-catenin supports tumorigenesis by maintaining mesenchymal progenitor cells in a less differentiated state. Protecting this progenitor cell population might prevent tumor formation in patients harboring a germline APC mutation, where fibromatosis is currently the leading cause of mortality. © 2010 AACR.

  3. Synchronous multicentric desmoid tumors (aggressive fibromatosis) of the extremities

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    Sundaram, M.; Duffrin, H.; Vas, W.; McGuire, M.H.

    1988-01-01

    Synchronous multicentric aggressive fibromatosis does not appear to have been previously reported. Two such cases are described. The tumors were identified by magnetic resonance (MR) imaging. The incidence of synchronous multicentric aggressive fibromatosis is not known. It is anticipated that increased use of coronal MR imaging will reveal more tumors of this type, both synchronous and metachronous. In a patient with known or suspected aggressive fibromatosis, every other soft tissue nodule or mass in the same limb has to be regarded as an additional tumor of the same histology. (orig.)

  4. Biology and Treatment of Aggressive Fibromatosis or Desmoid Tumor.

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    Skubitz, Keith M

    2017-06-01

    Aggressive fibromatosis, also known as desmoid-type fibromatosis (DTF) or desmoid tumor, is an uncommon locally invasive tumor. Because of its low incidence and variable behavior, DTF is often first seen by physicians who are not familiar with it, and recent advances in understanding this disease have led to changes in treatment approaches. The Wnt (β-catenin) pathway appears to play a key role in DTF pathogenesis, and recent studies of DTF biology suggest a possible model of DTF pathogenesis. Histologically, DTF shows a poorly circumscribed proliferation of myofibroblast-like cells with variable collagen deposition, similar to the proliferative phase of wound healing, and DTF has been associated with trauma and pregnancy. Desmoid-type fibromatosis may be a useful model of the tumor stroma in carcinomas as well as other fibrosing diseases such as progressive pulmonary fibrosis. The clinical course of DTF can vary greatly among patients, complicating the determination of the optimal treatment approach. Treatment options include surgery, nonsteroidal anti-inflammatory drugs with or without hormonal manipulation, chemotherapy, radiation therapy, and other forms of local therapy. Many treatments have been used, but these are not without toxicities. Because of the variable nature of the disease and the potential morbidity of treatment, some cases of DTF may do better without treatment; simple observation is often the best initial treatment. This review used a PubMed search from January 1, 1980, through October 31, 2016, using the terms fibromatosis and desmoid and discusses DTF disease characteristics, pathophysiology, and treatment options as well as examines several cases illustrating key points in the biology and treatment of this heterogeneous disease. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  5. The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors)

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    Lips, D.J.; Barker, N.; Clevers, H.; Hennipman, A.

    2009-01-01

    BACKGROUND: Aggressive fibromatosis (syn. desmoid tumor) is a sporadically occurring neoplastic proliferation of fibroblasts originating from musculoaponeurotic planes, forming invasively growing masses without the capability to metastasize. The choice of treatment remains surgical resection with or

  6. Ultrasound and MR imaging of fibromatosis colli (sternomastoid tumor of infancy)

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    Ablin, D.S.; Jain, K. [Department of Radiology, University of California, Sacramento, CA (United States); Howell, L. [Department of Pathology, University of California, Davis Medical Center, Sacramento, CA (United States); West, D.C. [Department of Pediatrics, University of California, Davis Medical Center, Sacramento, CA (United States)

    1998-04-01

    The sonographic and CT findings of fibromatosis colli (sternomastoid tumor of infancy) have been described, but the MRI appearance has been reported in only one case in which the mass resolved over time. This case describes the detailed MRI findings in a biopsy-proven case of fibromatosis colli; the signal intensity of the mass on T2-weighted images was slightly less than on gradient-recalled T1-weighted images, consistent with the presence of some fibrous tissue within the muscle mass. The involved portion of the muscle was better defined on MRI than sonography. MRI was helpful in demonstrating the signal characteristics of the mass; localizing the mass to within the sternocleidomastoid muscle; and demonstrating clear surrounding fascial planes with lack of associated lymphadenopathy, airway compression, vascular encasement, bone involvement or intracranial/intraspinal extension associated with other neck masses. (orig.) With 3 figs., 6 refs.

  7. Radiation-induced Sarcomas Occurring in Desmoid-type Fibromatosis Are Not Always Derived From the Primary Tumor.

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    Verschoor, Arie J; Cleton-Jansen, Anne-Marie; Wijers-Koster, Pauline; Coffin, Cheryl M; Lazar, Alexander J; Nout, Remi A; Rubin, Brian P; Gelderblom, Hans; Bovée, Judith V M G

    2015-12-01

    Desmoid-type fibromatosis is a rare, highly infiltrative, locally destructive neoplasm that does not metastasize, but recurs often after primary surgery. Activation of the Wnt/β-catenin pathway is the pathogenic mechanism, caused by an activating mutation in exon 3 of CTNNB1 (85% of the sporadic patients). Radiotherapy is a frequent treatment modality with a local control rate of approximately 80%. In very rare cases, this may result in the development of radiation-induced sarcoma. It is unclear whether these sarcomas develop from the primary tumor or arise de novo in normal tissue. In 4 tertiary referral centers for sarcoma, 6 cases of desmoid-type fibromatosis that subsequently developed sarcoma after radiotherapy were collected. The DNA sequence of CTNNB1 exon 3 in the desmoid-type fibromatosis and the subsequent postradiation sarcoma was determined. Sarcomas developed 5 to 21 years after the diagnosis of desmoid-type fibromatosis and included 2 osteosarcomas, 2 high-grade undifferentiated pleomorphic sarcomas, 1 fibrosarcoma, and 1 undifferentiated spindle cell sarcoma. Three patients showed a CTNNB1 hotspot mutation (T41A, S45F, or S45N) in both the desmoid-type fibromatosis and the radiation-induced sarcoma. The other 3 patients showed a CTNNB1 mutation in the original desmoid-type fibromatosis (2 with a T41A and 1 with an S45F mutation), which was absent in the sarcoma. In conclusion, postradiation sarcomas that occur in the treatment area of desmoid-type fibromatosis are extremely rare and can arise through malignant transformation of CTNNB1-mutated desmoid fibromatosis cells, but may also originate from CTNNB1 wild-type normal cells lying in the radiation field.

  8. Fibromatosis-like carcinoma-an unusual phenotype of a metaplastic breast tumor associated with a micropapilloma

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    Badwe Rajan A

    2007-02-01

    Full Text Available Abstract Background Fibromatosis-like metaplastic carcinoma is a newly described metaplastic breast tumor, literature on which is still evolving. Case presentation A 77-year-old lady presented with a 2 × 2 cm mass with irregular margins in the upper and outer quadrant of left breast. Fine needle aspiration cytology (FNAC from the lump was inconclusive. A lumpectomy was performed and sent for frozen section, which revealed presence of spindle cells showing mild atypia in a sclerotic stroma. The tumor cells revealed prominent infiltration into the adjacent fat. A differential diagnosis of a low-grade sarcoma vs. a metaplastic carcinoma, favoring the former, was offered. Final histology sections revealed an infiltrating tumor with predominant spindle cells in a collagenous background, simulating a fibromatosis. Adjacent to the tumor were foci of benign ductal hyperplasia and a micropapilloma. Immunohistochemistry (IHC showed diffuse co-expression of epithelial markers i.e. cytokeratins (CK, HMWCK, CK7 and EMA along with a mesenchymal marker i.e. vimentin in the tumor cells. Myoepithelial markers (SMA and p63 showed focal positivity. A diagnosis of a low-grade fibromatosis-like carcinoma breast associated with a micropapilloma was formed. Conclusion Fibromatosis-like carcinoma is a rare form of a metaplastic breast tumor. This diagnosis requires an index of suspicion while dealing with spindle cell breast tumors. The importance of making this diagnosis to facilitate an intra operative surgical planning is marred by diagnostic difficulties. In such cases, IHC is imperative in forming an objective diagnosis.

  9. Fibromatosis-like carcinoma-an unusual phenotype of a metaplastic breast tumor associated with a micropapilloma

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    Rekhi, Bharat; Shet, Tanuja M; Badwe, Rajan A; Chinoy, Roshni F

    2007-01-01

    Background Fibromatosis-like metaplastic carcinoma is a newly described metaplastic breast tumor, literature on which is still evolving. Case presentation A 77-year-old lady presented with a 2 × 2 cm mass with irregular margins in the upper and outer quadrant of left breast. Fine needle aspiration cytology (FNAC) from the lump was inconclusive. A lumpectomy was performed and sent for frozen section, which revealed presence of spindle cells showing mild atypia in a sclerotic stroma. The tumor cells revealed prominent infiltration into the adjacent fat. A differential diagnosis of a low-grade sarcoma vs. a metaplastic carcinoma, favoring the former, was offered. Final histology sections revealed an infiltrating tumor with predominant spindle cells in a collagenous background, simulating a fibromatosis. Adjacent to the tumor were foci of benign ductal hyperplasia and a micropapilloma. Immunohistochemistry (IHC) showed diffuse co-expression of epithelial markers i.e. cytokeratins (CK, HMWCK, CK7) and EMA along with a mesenchymal marker i.e. vimentin in the tumor cells. Myoepithelial markers (SMA and p63) showed focal positivity. A diagnosis of a low-grade fibromatosis-like carcinoma breast associated with a micropapilloma was formed. Conclusion Fibromatosis-like carcinoma is a rare form of a metaplastic breast tumor. This diagnosis requires an index of suspicion while dealing with spindle cell breast tumors. The importance of making this diagnosis to facilitate an intra operative surgical planning is marred by diagnostic difficulties. In such cases, IHC is imperative in forming an objective diagnosis. PMID:17324295

  10. Mesenteric fibromatosis representing as a colo-colic intussusception mimicking the ascending colon malignant tumor with CT and {sup 18}F-flurodeoxyglucose position emission tomography/CT findings: A case report

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    Lee, Jae Hyun; Ha, Hong Il; Kim, Min Jeong; Hwang, Jin Ho; Lee, Kwan Seop [Dept. of Radiology, Hallym University Medical Center, Hallym University Sacred Heart Hospital, Anyang (Korea, Republic of)

    2016-04-15

    Mesenteric fibromatosis is a rare benign fibroblastic tumor; moreover, cases that occur in the mesocolon are even rarer. In some cases, mesenteric fibromatosis is difficult to differentiate from a malignant tumor that shows an infiltrative growth pattern or forms intussusception similar to lymphoma or adenocarcinoma. In this study, we reported a case of mesenteric fibromatosis represented as a colo-colic type intussusception adjacent to the ascending colon mimicking malignant tumors such as lymphoma or adenocarcinoma.

  11. Breast fibromatosis associated with breast implants.

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    Seo, Yoon Nae; Park, Young Mi; Yoon, Hye Kyoung; Lee, Sun Joo; Choo, Hye Jung; Ryu, Ji Hwa

    2015-09-01

    Fibromatosis refers to an extra-abdominal desmoid tumor or aggressive fibromatosis. Breast fibromatosis can develop in association with the capsule around a breast implant, although reports of cases of fibromatosis associated with breast implants are rare. As the demand for breast augmentation has increased, it is important to understand the diseases associated with breast implants. In the present report, we describe a case of breast fibromatosis that developed adjacent to a breast implant and demonstrated a relatively well-defined border even though it invaded the surrounding structures. We also explore the specific imaging features for diagnosing breast fibromatosis in association with implants by reviewing previous literature.

  12. Aggressive intraabdominal fibromatosis

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    Stojković Mirjana

    2006-01-01

    Full Text Available Background. Intraabdominal or mesenteric fibromatosis is a rare benign nonmetastatic neoplasm that appears as a sporadic lesion or in patients with familiar polyposis. Its evolution is unpredictable. About 10% of the cases show a very aggressive growth. Case report. We presented a 22-year-old woman in whom an aggressive intraabdominal fibromatosis had appeared during the first pregnancy as a well circumscribed ovoid tumor, involving the terminal ileum, the caecum, the ascending colon, the right kidney, the ureter, and the right common iliac artery. The tumor was excised with right colectomy, nephroureterectomy and resection of the involved artery using arterial reconstruction with graft interposition. Two years after the surgery the patient developed an inoperable tumor recurrence with a fatal outcome. Conclusion. In spite of a successful surgical excision during the original surgery intraabdominal or mesenteric fibromatosis might have an aggressive evolution leading to an inoperable tumor recurrency and a fatal outcome.

  13. Fibromatosis in vertical rectus abdominis myocutaneous flap imitating tumor recurrence after surgery for locally advanced rectal cancer: case report.

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    Goscinski, Mariusz Adam; Hole, Knut Håkon; Tønne, Elin; Ryder, Truls; Grøholt, Krystyna Kotanska; Flatmark, Kjersti

    2016-03-03

    Abdominoperineal excision is performed in patients with locally advanced, low rectal carcinoma. Reconstruction of the dorsal vagina and perineum using the vertical rectus abdominis myocutaneous flap following extensive surgery results in favorable surgical outcome and quality of life. However, the rectus abdominis muscle, as part of the anterior abdominal wall, may develop fibrous lesions also as a transplant. A 39-year-old female patient with low rectal cancer and extensive colorectal polyposis was treated with neoadjuvant chemoradiotherapy followed by colectomy and abdominoperineal excision with resection of the dorsal vaginal wall and subsequent reconstruction of the perineum using the vertical rectus abdominis myocutaneous flap. At the 6-month follow-up, a suspected 2 × 2 cm tumor recurrence was detected in the transposed tissue and was subsequently surgically removed. Histologic examination concluded with fibromatosis. Genetic testing revealed a known disease-causing mutation in the adenomatous polyposis coli gene, confirming the diagnosis of familial adenomatous polyposis. Fibromatosis may affect the anterior abdominal wall, that is the rectus abdominis muscle, at the primary site or may develop in the muscle after its transposition into the perineum at pelvic reconstruction. Fibromatosis in the muscle flap after pelvic reconstruction may present a difficult diagnostic challenge for the multidisciplinary team.

  14. Aggressive fibromatosis of anterior maxilla

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    Devi C Shetty

    2011-01-01

    Full Text Available Aggressive fibromatosis is a comparitively rare tumor with unpredictable growth and varying local recurrence rates. It does not develop distant metastases but locally it shows an aggressive and infiltrative behavior. Clinically, aggressive fibromatosis manifests as a painless, firm, often rapidly enlarging mass, fixed to underlying bone or soft tissue. It is never encapsulated. Histologically, it is rich in collagen and fibroblastic cells that are devoid of hyperchromatic or atypical nuclei, but with more variable cellularity in different tumor sections.

  15. AGGRESSIVE FIBROMATOSIS (NONFAMILIAL DESMOID TUMOR) - THERAPEUTIC PROBLEMS AND THE ROLE OF ADJUVANT RADIOTHERAPY

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    PLUKKER, JT; VANOORT, [No Value; VERMEY, A; MOLENAAR, [No Value; HOEKSTRA, HJ; PANDERS, AK; DOLSMA, WV; KOOPS, HS

    1995-01-01

    Aggressive fibromatosis is a rare soft tissue tumour with a high tendency to local recurrence, even after apparently adequate resection. Wide local excision with a margin of at least 3 cm, depending on the anatomical location, should be performed to improve rates of recurrent disease. There is no co

  16. Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor:A case report

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    Piergiuseppe Colombo; Daoud Rahal; Fabio Grizzi; Vittorio Quagliuolo; Massimo Roncalli

    2005-01-01

    Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract. Although rare, it is the most common primary tumor of the mesentery and can develop at any age. We describe a rare case of primary IAF involving the mesentery and small bowel which clinically, macroscopically and histologically mimicked malignant gastrointestinal stromal tumor (GIST). This report highlights the fact that benign IAF can be misdiagnosed as a malignant GIST localized in the mesentery or arising from the intestinal wall. Their diagnostic discrimination is essential because of their very different biological behaviors and the fact that the introduction of effective therapies involving tyrosine kinase inhibitor STI571 (imatinib mesylate) has greatly changed the clinical approach to intra-abdominal stromal spindle cell tumors.

  17. Plantar fibromatosis.

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    Zgonis, Thomas; Jolly, Gary Peter; Polyzois, Vasilios; Kanuck, David M; Stamatis, Emmanouil D

    2005-01-01

    Plantar fibromatosis is defined as a benign fibrous disorder involving the plantar aponeurosis. Although its incidence is well described on the hands, it is less commonly seen on the feet, and its etiology is unknown. A differential diagnosis for the heel pain along the medial arch could be a benign thickening of the plantar fascia associated with plantar fibromatosis. Its high recurrence after surgical excision and problematic scarring and wound presents a significant challenge to the reconstructive foot and ankle surgeon. This article reviews the history, clinical presentation, pathologic findings, and surgical approaches to the treatment of plantar fibromatosis.

  18. Fibromatosis of the Sigmoid Colon With CTNNB1 (β-Catenin) Gene Mutation, Arising at the Site of Ileocolic Anastomosis for Resection of Gastrointestinal Stromal Tumor.

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    Thway, Khin; Abou Sherif, Sara; Riddell, Angela M; Mudan, Satvinder

    2016-05-01

    We describe a case of intra-abdominal fibromatosis, which occurred in a 44-year-old woman who had a previous history of gastrointestinal stromal tumor (GIST) of the sigmoid mesocolon, which was treated with imatinib and resection. A mass was detected at the site of ileocolic anastomosis of the previous small bowel resection and sigmoid colectomy, nearly 3 years later. Clinically, this was suspected to represent recurrent GIST and was excised, but histology and mutational analysis showed desmoid-type fibromatosis with a mutation in codon 41 of exon 3 of the CTNNB1 (β-catenin) gene. The occurrence of fibromatosis at the site of excision of GIST is very rare, but its recognition is important as the treatment of the two neoplasms differs significantly. As imaging cannot reliably distinguish between these 2 entities, histological diagnosis is crucial for correct clinical management. © The Author(s) 2015.

  19. Aggressive juvenile mandibular fibromatosis.

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    Ivanov, Georgi P; Atanasov, Dimitar T; Anavi, Beniamin L

    2013-01-01

    Aggressive juvenile fibromatosis of the jawbones is a rare tumor presenting as infiltrative mass with unpredictable evolution. We report herein a 17-year-old student with a 6-month history of radiologically proven resorption of a part of the mandible, lingual displacement of tooth 34 and malocclusion. Alveolar ridge resorption and three dark-brown foci in the bone were seen after the tooth was extracted. Histological study showed the tumor tissue to have a bundle-like structure; immunohistochemically it was positive for vimentin, smooth muscle actin, beta-catenin, Ki-67 (5%), and negative for desmin and cytokeratin 34bE12. The golden standard in the diagnostics of desmoid fibromatoses is the nuclear or membrane expression of beta-catenin, which is found in 90% of the cases. Differential diagnosis include mandibular fibroma, well-differentiated fibrosarcoma, fibrosing histiocytoma, and infiltration from adjacent soft-tissue tumor. Aggressive juvenile fibromatosis should be managed by radical excision. Local recurrences are not rare, but metastases do not develop. In rare cases this type of fibromatosis has been known to regress spontaneously. Aggressive fibromatosis is a diagnostic challenge, since it remains in the grey zone between benign and malignant lesions of the oral cavity.

  20. Fibromatosis of the Submandibular Region

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    Ying-Nan Chang

    2009-09-01

    Full Text Available Fibromatoses are benign tumors that can occur anywhere in the body. They are locally aggressive and tend to recur; they also cause considerable morbidity, particularly when they arise in the head and neck. Fibromatosis in the submandibular region is rare. Here, we present a case of fibromatosis of the submandibular region in a 42-year-old female who presented with a right submandibular mass. The patient underwent complete excision of the fibromatosis, showed negative margins and had no adjuvant therapy. Her recovery was uneventful, and there was no recurrence or neurological deficit 1 year after the operation.

  1. Multicentric synchronous recurrent aggressive fibromatosis

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    Kavita Kohli

    2012-01-01

    Full Text Available Extra-abdominal desmoid tumors are known as aggressive fibromatosis (AFM. Synchronous and metachronous multicentric aggressive fibromatosis are rare lesions and pose dilemma in diagnosis and management. A rare and interesting case of recurrent multicentric, synchronous AFM is presented which to the best of our knowledge has not been reported earlier. A young male presented with well defined, hard, fixed swelling on the thigh. Resected tumor mass on histopathology was diagnosed as an extra abdominal fibromatosis. He presented again after two months with swelling at the same site; and two more swellings on the foot. Fine needle aspiration cytology (FNAC from all three sites was performed; and was suggestive of benign spindle cell lesion of fibrogenic origin with the possibility of multicentric synchronous recurrent aggressive fibromatosis.

  2. Recurring fibromatosis of breast following tumorectomy: a case report

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    Kim, Kum Rae; Park, Won Kyu; Hwang, Mi Soo; Cho, Jae Ho; Bae, Young Kyung [College of Medicine, Yeungnam University, Daegu (Korea, Republic of)

    2008-02-15

    A fibromatosis or desmoid tumor of the breast is an extremely rare benign tumor, which is often presented clinically and radiologically as a malignant tumor. Although benign, fibromatosis or desmoid tumors can grow aggressively in local infiltrating patterns. The recurrence is relatively common; hence a wide excision with a clear margin around the tumor is necessary. We report a case of a young female patient with a recurring fibromatosis of the breast after a local excision.

  3. Incidental Finding and Management of Mesenteric Fibromatosis.

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    Nicolas, Gregory; Kfoury, Tony; Shimlati, Rasha; Tohme, Maroon; Wakim, Raja

    2016-06-09

    Mesenteric fibromatosis, also known as mesenteric desmoids, is part of the clinical-pathologic spectrum of deep fibromatosis, which encompasses a group of benign fibro-proliferative processes that are locally aggressive and have the capacity to infiltrate or recur without metastasis. Case of a 45-year-old man, with a history of hypertension and lung fibrosis, presenting for a left abdominal mass, which was found incidentally during his lung fibrosis imaging. He complained of constipation due to pressure upon his bowel leading to difficulty in defecation. Although there are many overlapping criteria between gastrointestinal stromal tumors and mesenteric fibromatosis, making it difficult to discriminate between the two, there are differences that are unique to mesenteric fibromatosis that should be noticed during the diagnosis. In this case, mesenteric fibromatosis was unusual as it is not associated with Gardner's syndrome, desmoid tumors, nor familial adenomatous polyposis, but was an incidental finding.

  4. Aggressive Fibromatosis in Neck.

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    Namita Kabdwal

    2013-01-01

    Full Text Available Aggressive fibromatosis (AF is a locally aggressive infiltrative low-grade benign tumor that accounts for approximately less than 3% of all soft tissue tumors. In the head and neck region this tumor tends to be more aggressive and associated with significant morbidity. Aggressive surgery is a viable management option and may be successfully used as a single modality treatment, or in combination with radiotherapy. We report a rare case of AF in a 38 year old female, who presented with a painless mass over the left supraclavicular fossa, extending inferiorly into the thoracic inlet, which was excised successfully in toto with the help of cardiothoracic vascular surgeon (CTVS.

  5. [Inclusion body fibromatosis: a case report].

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    Zouaidia, F; Boralevi, F; Vergnes, P; Coindre, J-M; Lepreux, S

    2012-03-01

    Infantile digital fibromatosis or inclusion body fibromatosis is a rare, benign fibroproliferative lesion with recurrent potential that occurs on the digits of infants. A highly characteristic morphologic finding is the presence of paranuclear inclusion within the tumoral cells. We report here a case occurring in an 8-month-old infant with 2 asynchronous lesions of the toes. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  6. Sonographic evaluation of fibromatosis colli

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    Lee, Sun Wha [Hallym University College of Medicine, Chuncheon (Korea, Republic of); Ryu, Kyung Nam [Ewha Womans University College of Medicine, Seoul (Korea, Republic of); Park, Ki Soon [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    1993-12-15

    Congenital muscular torticollis is frequently associated with a sternocleidomastoid tumor, which is known alternatively as fibromatosis colli. The sonographic appearance in 24 infants with fibromatosis colli was studied. The majority of the masses was on the right side. Sonographic evidence of a discrete mass lesion within the sternocleidomastoid muscle was detected in all 25 lesions. Sixteen masses involved both the sternal and calvicularportions. The masses predominantly involved the lower two thirds of the sternocleidomastoid muscle. Eighteen masses (72%) had homogeneous echo-texture, which were hyper echoic in 15 cases and isoechoic in three cases. Seeven(28%) had patchy echo-texture. There was a higher incidence of patchy echo-texture in younger age group. A hypoechoic rim surrounding the mass was frequently present (80%). In conclusion, we think ultrasonography is a valuable method for the diagnosis and evaluation of fibromatosis colli over clinical method. Further prospectiveand controlled sonographic evaluation of fibromatosis colli are needed to provide objective guidelines of the management of this disease

  7. Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up.

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    Laskin, William B; Miettinen, Markku; Fetsch, John F

    2009-01-01

    The clinicopathologic and immunohistochemical features of 69 pediatric examples of infantile digital fibroma/fibromatosis (IDF) were analyzed. Thirty males, 26 females, and 1 child (sex unstated) ranging from newborn to 120 months of age (median, 12 mo) manifested 74 lesions (5 identified in follow-up) involving the toe or finger (n=71) and the hand or foot (n=3). Tumors ranged in size from 3 to 35 (median, 10) mm. All but 4 study members presented with a solitary lesion. Metachronous IDFs developed in 7 patients within 17 to 82 months. Microscopically, a cytologically bland, fibroproliferative lesion was observed forming a dome-shaped/polypoid nodule directly beneath the epidermis and invading dermal adnexa. Mitotic figures per 20 high-powered fields ranged from 0 to 7 (median, 1). Paranuclear cytoplasmic inclusions were identified in 57 tumors. Tumor cells immunohistochemically expressed calponin (11 of 11 tumors), desmin (9/9), alpha-smooth muscle actin (11/11), CD99 (11/11), CD117 (6/8), heavy caldesmon (2/11 and scattered cytoplasmic inclusions in 4 tumors), CD10 (1/9), nuclear beta-catenin (2/11), and CD34 (1/11), but not muscle actin (HUC1-1), keratins, estrogen/progesterone receptor proteins, or activated caspase-3. Twenty-eight of 38 patients (74%) experienced recurrent/persistent disease (single in 22; multiple in 6) (median, 4 mo after surgery). One recurrent tumor spontaneously regressed and the size of another remained unchanged for almost 17 years before reexcision. All 23 patients with >5 years follow-up are currently disease free (median disease-free interval, 23 y). Minor postoperative functional/cosmetic complaints were reported in 47%. No patient with adequate clinical data developed the digitocutaneous dysplasia syndrome or a conventional fibromatosis, or relayed a family history of IDF/conventional fibromatosis. Our results indicate that IDF is a unique myofibroblastic process separable from conventional fibromatoses and from histologic mimics

  8. Idiopathic gingival fibromatosis

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    Dani, Nitin Hemchandra; Khanna, Dinkar Parveen; Bhatt, Vaibhavi Hitesh; Joshi, Chaitanya Pradeep

    2015-01-01

    Idiopathic gingival fibromatosis (IGF) is a rare hereditary condition characterized by slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva caused by increase in submucosal connective...

  9. Vulvar fibromatosis: a clinical enigma.

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    Conroy, Erin M; Frimer, Marina; Karabakhtsian, Rouzan G; Gorlick, Richard; Goldberg, Gary L

    2015-01-01

    To present a case of recurrent vulvar fibromatosis in an adolescent, discuss the specific difficulties of treating adolescents, and review the literature on available treatment. We present a case of recurrent vulvar fibromatosis in a 14-year-old girl, requiring several treatment modalities, including multiple surgeries, radiation therapy, and multiagent chemotherapy. We then discuss management strategies for these tumor types, and specifically examine how tumor location may impact their treatment. Vulvar desmoids are extremely uncommon and they can be disfiguring and cause significant discomfort for women. Initial management of these tumors is surgical excision, yet failed surgery is often followed by other treatment modalities, including radiation, tyrosine kinase inhibitors, nonsteroidal anti-inflammatory drugs, hormonal therapy, and chemotherapy. This case clearly highlights the difficulties in managing these rare tumors, particularly in the adolescent population. Desmoid tumors are nonmalignant, locally aggressive neoplasms most common in the 15 to 60 years age group. They are associated with high estrogen states, prior surgical trauma, and Gardner syndrome. Most commonly, desmoid tumors present in the abdominal wall, shoulder, neck, and chest, but can occur anywhere in the body. Given their rarity and lack of definitive therapy, vulvar desmoid tumors can be exceedingly difficult to treat, and are best managed with an interdisciplinary approach.

  10. Neuropathic pain due to fibromatosis: Does anticancer treatment help?

    Directory of Open Access Journals (Sweden)

    David Mathew

    2011-01-01

    Full Text Available Desmoid fibromatosis, although histologically benign, infiltrates local structures. The involvement of neural structures can lead to difficult neuropathic pain and the escalating use of analgesics. We report a patient with desmoid fibromatosis of the chest wall causing brachial plexus infiltration. As the tumor was locally invasive and unresectable, he was treated with radiation therapy and oral tamoxifen. On follow-up, there was significant pain relief, sustained reduction in the tumor size, and reduced analgesic requirement. Antineoplastic treatments like local radiation therapy and targeted systemic therapy with hormones or other agents can be considered in the management of selected unresectable desmoid fibromatosis to improve symptom control and reduce polypharmacy.

  11. Fibromatosis stem cells rather than bone-marrow mesenchymal stem cells recapitulate a murine model of fibromatosis.

    Science.gov (United States)

    Wang, Jung-Pan; Hui, Yun-Ju; Wang, Shih-Tien; Huang, Yi-Chao; Chiang, En-Rung; Liu, Chien-Lin; Chen, Tain-Hsiung; Hung, Shih-Chieh

    2011-05-06

    Palmar fibromatosis is a benign fibroproliferative tumor of unknown etiology, with a high rate of recurrence after excision. The offending cells of palmar fibromatosis are myofibroblasts and the cellular origin of other myofibroblasts has previously been reported to be the bone marrow. However, further clarification of the relationship between bone marrow precursors and palmar fibromatosis is required. Stem cells (SCs) are known to exist in various tissues, but whether SCs can be isolated from fibromatosis tissue is still unclear. The purpose of this study was to isolate and identify stem cells from human palmar fibromatosis, and to evaluate the differences in the differentiation and fibrogenic capacities of bone marrow stem cells (BMSCs) and fibromatosis-derived stem cells (FSCs). We found that FSCs had better fibrogenic differentiation potential than BMSCs, whereas BMSCs had better adipogenic and chondrogenic differentiation capacities. Treatment with transforming growth factor-β1 increased the expression of α-smooth muscle actin, and types III and I collagen significantly more in FSCs than in BMSCs. An in vivo study further confirmed the results of fibrogenesis and suggested that FSCs can recapitulate the fibromatosis nodule. In summary, their myofibroblastic differentiation both in vivo and in vitro makes FSCs a potential cell source for future applications in murine models of fibromatosis or fibrogenesis. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. Bilateral breast fibromatosis: case report and review of the literature.

    Science.gov (United States)

    Taylor, Thomas V; Sosa, Jose

    2011-01-01

    Fibromatosis or desmoid tumor is a benign, slow-growing fibroblastic neoplasm originating from musculoaponeurotic stromal elements. These tumors are characterized by an infiltrative and locally aggressive growth pattern, frequent recurrences, but no metastatic potential. The etiology is unknown, but these tumors have been associated with trauma and genetic disorders. Breast fibromatosis is exceedingly rare and often misdiagnosed, comprising only 0.2% of breast tumors. Clinically, it might mimic other breast lesions, such as carcinoma. Only approximately 6 case series and 100 case reports of this disorder affecting the breast are documented, and only 5 cases of bilateral breast fibromatosis have been reported. We describe the case of a 20-year-old woman who presented to our institution with firm, nontender masses palpable in both breasts. Prior ultrasound was suspicious for carcinoma, and breast core biopsies were suggestive of phyllodes tumor. An excisional biopsy was necessary to establish the diagnosis of breast fibromatosis for both masses. A review of articles published on desmoid tumors and breast fibromatosis was performed with emphasis on articles published in the last 10 years. Fibromatosis should be considered in the differential diagnosis of patients presenting with hard breast lumps suspicious of other diseases. Copyright © 2011 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  13. Fibromatosis of infratemporal space.

    Science.gov (United States)

    Warraich, Riaz Ahmed; Saeed, Tooba; Riaz, Nabila; Aftab, Asma

    2016-02-01

    Fibromatosis is a rare benign mesenchymal neoplasm which primarily originates in the muscle, connective tissue, fascial sheaths, and musculoaponeurotic structures. It is commonly seen as abdominal tumour but in maxillofacial region, the occurrence of these tumours is very rare and exceedingly rare in infratemporal space. Often misdiagnosed due to its varied clinical behaviour, fibromatosis is benign, slow-growing, infiltrative tumour without any metastatic potential, but is locally aggressive causing organ dysfunction along with high recurrence rate. We report a case of fibromatosis involving the left infratemporal space in a 35-year-old female who presented with chief complaint of limited mouth opening for the preceding 4 years.

  14. The etiopathogenesis of uterine fibromatosis

    Science.gov (United States)

    Manta, L; Suciu, N; Toader, O; Purcărea, RM; Constantin, A; Popa, F

    2016-01-01

    Uterine fibroids or uterine leiomyomas are the most common benign tumors of the uterus among women of fertile age, while the etiology is still incompletely elucidated. The occurrence and development of the fibromatosis may be related to certain risk factors and genic mechanisms, although the exact causes are not yet fully known. The development of uterine fibroids is correlated not only with the metabolism and with the level of female sexual hormones, estrogen, and progesterone, but also with the number of these hormone receptors expressed on the surface of the myometrium. Proliferative effects of estrogen and progesterone may be exercised through proinflammatory factors (TNF alpha), growth factors (IGF1, IGF2, TGFbeta3 and betaFGF) or inhibitors of apoptosis (p53 suppression). A number of predisposing factors such as ethnicity – black skin, early menarche, nulliparity, caffeine and alcohol, chronic inflammation, obesity, were also identified. Approximately 40% of the uterine fibroids are caused by the same cytogenetic alterations found in the other tumor types such as kidney, lung, or leiomyosarcoma. As part of a system dysfunction, uterine fibromatosis was connected to other disorders such as AHT (arterial hypertension), endometrium adenocarcinoma, adenomyosis, endometriosis, diabetes mellitus, breast tumors, seemingly with a common causality. The action and effect of some hormonal imbalances over the various organs depend on the histological and local expression particularities of the various receptors, being the cause for many disorders, among which the uterine fibromatosis, coexisting or accompanying the later. This article examines and summarizes the latest data refreshed literature etiopathogenesis offering indicators of uterine fibroids. PMID:27974911

  15. Sporadic Giant Mesenteric Fibromatosis

    National Research Council Canada - National Science Library

    Sinukumar, Snita; Gomes, Rachel M; Kumar, Rajiv K; Desouza, Ashwin; Saklani, Avanish

    2014-01-01

    Mesenteric fibromatosis is an uncommon tumour which is locally aggressive without any metastatic potential and can occur as a sporadic event or in association with familial adenomatous polyposis syndrome...

  16. The analysis of treatment of aggressive fibromatosis using oral methotrexate chemotherapy.

    Science.gov (United States)

    Yoon, Gi Woon; Kim, Jae Do; Chung, So Hak

    2014-12-01

    Aggressive fibromatosis is a rare but invasive tumor infiltrating widely between fascia and muscle fibers. It has a high tendency to be locally recurrent despite complete resection. Effectiveness of adjuvant treatment for aggressive fibromatosis including radiotherapy, pharmacological agents, hormonal treatments, and chemotherapy have been previously reported. The purpose of this article was to collect and analyze all information regarding the effectiveness and side effects of oral methotrexate in aggressive fibromatosis. From 2005 to 2011, eleven patients with aggressive fibromatosis treated with oral methotrexate at our institution were analyzed in this study. Oral methotrexate was administered once per week at 10 mg per week. Authors collected information about effectiveness concerning cases of local recurrence and metastasis. Eleven patients had remission, two patients had local recurrence. Fatal complications or toxicity were not observed. Oral methotrexate given at this dose and schedule was considered as a useful treatment in primary inoperable fibromatosis and recurrent fibromatosis.

  17. [Fibromatosis breast in the male. Case study].

    Science.gov (United States)

    Muñoz-Atienza, Virginia; Manzanares-Campillo, María Del Carmen; Sánchez-García, Susana; Pardo-García, Ricardo; Martín-Fernández, Jesús

    2013-01-01

    Antecedentes: la fibromatosis mamaria es una enfermedad rara; sus casos son 0.2% de las neoplasias de mama, y en los varones es aún más rara. El diagnóstico definitivo es anatomopatológico. Caso clínico: se comunica el caso de un varón de 52 años, con diagnóstico anatomopatológico de fibromatosis mamaria posterior al estudio de un tumor en la mama derecha. Se le practicó exéresis con amplios márgenes, luego mastectomía subcutánea, con estudio histológico de fibromatosis con márgenes libres. El postoperatorio transcurrió sin complicaciones y no requirió tratamiento coadyuvante. En el seguimiento a seis meses continuaba libre de enfermedad. El tratamiento de elección es la escisión con amplios márgenes y el oncológico coadyuvante es motivo de controversia. Conclusiones: la fibromatosis en la mama es poco frecuente y su aparición en el varón excepcional. El tratamiento quirúrgico es el definitivo, no así la terapia oncológica neoadyuvante que sigue suscitando controversia.

  18. Differential diagnostic considerations of desmoid-type fibromatosis.

    Science.gov (United States)

    Goldstein, Jeffery A; Cates, Justin M M

    2015-07-01

    Fibrous and myofibroblastic tumors of soft tissue often present the surgical pathologist with a difficult differential diagnosis because of the number of diagnostic possibilities and morphologic similarities among cytologically bland spindle-cell tumors. Prototypical in this regard is desmoid-type fibromatosis. In a review of 320 surgical specimens diagnosed as desmoid tumor, 94 (29%) were discovered to be misclassified as such. The most common lesions in this series were Gardner fibroma, scar tissue, superficial fibromatosis, nodular fasciitis, myofibroma, and collagenous fibroma. Four sarcomas were also misinterpreted as desmoid-type fibromatosis (3 low-grade fibromyxoid sarcomas and 1 unclassified spindle-cell sarcoma). We take this opportunity to compare and contrast desmoid tumor and several of the soft tissue tumors that should be considered in the differential diagnosis thereof.

  19. Recidivant desmoide fibromatosis of anterior abdominal wall et desmoide fibromatosis of retroperitoneum: Case report

    Directory of Open Access Journals (Sweden)

    Marijanović G.

    2015-01-01

    Full Text Available Desmoide or aggressive fibromatosis belong to the group of benign tumor characterized by a locally infiltrative growth and tendency to recur and which do not metastasize. Here is shown 46 years old woman who is coming for examination because of recurrent tumors of the anterior abdominal wall, PH earlier verified as desmoide fibromatosis. With a tumor of the anterior abdominal wall measuring 14.7 x 7.0 x 12.5 cm, CT diagnostics discovered a tumor size of 5.8 x 8.8 cm 6,2x in the lodge earlier removed right kidney, which is in close communication with v. cava inferior (VCI and A. Illiaca comunis dex. (AIC dex.. Compression of VCI and AIC has resulted in swelling of the right leg as a whole who retired after excision of the tumor. The postoperative course was uneventful.

  20. Scintigraphy of aggressive fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Hudson, T.M.; Bertoni, F.; Enneking, W.F.

    1985-01-01

    Thirteen patients with aggressive fibromatosis underwent skeletal scintigraphy and computed tomography as part of their preoperative staging. Bone involvement was visible on plain radiographs of three patients. For the other 10 patients, the presence or absence of bone involvement was shown best by computed tomography (CT) in five instances, and best by scintigraphy only once. The two studies were equally useful four times. Although skeletal scintigraphy has previously been fount to be very accurate for the evaluation of bone involvement by soft tissue sarcomas, it was less useful in these patients with aggressive fibromatosis.

  1. [Plantar fibromatosis (Ledderhose's disease)].

    Science.gov (United States)

    Koudela, K; Koudela, K; Kunešová, M; Koudelová, J

    2010-08-01

    The authors describe the concomitant presence of plantar fibromatosis and Dupuytren's disease in a 33-year-old man. A lesion located under the sesamoid bones of the first metatarsophalangeal joint on the right showed an aggressive tendency (rapid growth, pain, impossibility to put weight on the medial side of the foot). Another lesion located proximal to the first one was smaller and painless. Neither plain radiography nor computed tomography showed any structural changes of the skeleton. Contrast-enhancement on magnetic resonance imaging revealed two lesions on the sole of the foot. Since a concurrence of plantar fibromatosis and malignant tumour could not be ruled out, an excision of both lesions and the adjacent plantar aponeurosis was made for biopsy examination. The operative procedure was carried out from two incisions.The intra-operative findings included proliferative growth and bleeding in the lesion located under the first metatarsophalangeal joint, and delimited growth without noticeable bleeding in the other lesion. Based on histological examination, the diagnosis of plantar fibromatosis was made for both lesions.The differential diagnosis and therapy of plantar fibromatosis is discussed.

  2. MR findings of extra abdominal fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hee Jin; Lee, Sung Moon; Rhee, Chang Soo; Sohn, Chul Ho; Lee, Hee Jung; Kim, Jung Sik; Kim, Hong [Dongsan Medical Center, Keimyung Univ. College of Medicine, Taegu (Korea, Republic of); Seo, Kyung Jin [Suh Joo MRI center, Seoul (Korea, Republic of); Jo, Kil Ho [Youngnam Univ. College of Medicine, Kyongsan (Korea, Republic of)

    1999-12-01

    To evaluate the MR findings of extra-abdominal fibromatosis and the role of MRI in primary diagnosis Fifteen cases in of histologically proven extra-abdominal fibromatosis in 13 patients were retrospectively reviewed. T1-weighted and T2-weighted images were obtained in axial, coronal and sagittal planes. Gd-enhancement was performed in 14 cases, and dynamic enhancement studies in two. All lesions were evaluated for mass shape and margin definition. Among the 15 cases, tumors of the buttock accounted for five, and tumor of the thigh for two. in eight cases tumors were intermuscular and in six cases were intramuscular. In ten cases (67%) the mass extended along the long axis of the body and in 14 of 15 cases (93%) focal infiltration of adjacent structures was visible. The signal intensity of the lesion was in all cases inhomogeneous on both T1 and T2 weighted images. As seen on Gd-DTPA enhanced scans, the masses were inhomogeneously enhanced. In all cases MRI revealed star-shaped linear strands or a band-like low signal area in the mass. These features were not enhanced and were arranged along the long axis of the mass. MR findings of extra-abdominal fibromatosis were relatively characteristic and helpful for primary diagnosis of the condition.

  3. Morphologic Spectrum of Desmoid-Type Fibromatosis.

    Science.gov (United States)

    Zreik, Riyam T; Fritchie, Karen J

    2016-03-01

    Desmoid-type fibromatosis is a locally aggressive neoplasm composed of long sweeping fascicles of bland fibroblasts/myofibroblasts. Tumors with classic features are easy to identify, but the morphologic spectrum of this entity spans beyond the conventional histologic pattern. Since sampling of an unrecognized histologic variant may lead to misdiagnosis, especially on small needle biopsy specimens, we sought to fully characterize the morphologic spectrum of this entity. We examined 165 cases of desmoid-type fibromatosis and catalogued the morphologic patterns and percentage of those patterns identified in each case. Clinicopathologic variables, including age, sex, location, and recurrence, were analyzed and correlated with pattern frequency. Seven morphologic patterns were identified, including conventional, hyalinized/hypocellular, staghorn vessel, myxoid, keloidal, nodular fasciitis-like, and hypercellular. The mean number of patterns per case was two, but some cases harbored up to five patterns. The greatest morphologic variability was seen in the intra-abdominal lesions, with these tumors having a significantly higher percentage of the keloidal and staghorn patterns compared with extra-abdominal and abdominal wall sites. No significant correlation between patient outcome (recurrence) and presence of variant morphologic pattern was observed (P = .549). The morphologic spectrum of desmoid-type fibromatosis is deceptively broad, and awareness of the variety of histologic patterns is critical for accurate diagnosis. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  4. Ovarian fibromatosis and sotos syndrome with a new genetic mutation.

    Science.gov (United States)

    Beurdeley, M; Sabourin, J C; Drouin-Garraud, V; Liard, A; Bachy, B; Vivier, P H

    2013-04-01

    Sotos syndrome is one the most common overgrowth conditions, after Beckwith-Wiedemann syndrome. As with other overgrowth syndromes, Sotos syndrome can be associated with an increased risk of tumors. We describe a young girl with Sotos syndrome and ovarian fibromatosis with a new mutation not reported before in the literature. Development of ovarian tumor in Sotos syndrome has been poorly documented. Ovarian fibromatosis is a very rare non neoplastic disease. Management is guided by the benignity of the lesion and consists of surgical excision of the fibroma. Copyright © 2013 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

  5. Deep Neck Fibromatosis After Diskectomy and Cervical Fusion: Case Series and Review of the Literature.

    Science.gov (United States)

    Lacayo, Eduardo A; Glastonbury, Christine M; Hoang, Jenny K; Magliocca, Kelly R; Hill, Kenneth L; Hudgins, Patricia A

    2016-05-01

    The objective of our study was to report head and neck deep fibromatosis as part of the differential diagnosis of a firm painful neck mass after cervical fusion and diskectomy. Although they are rare tumors, fibromatosis tumors or desmoid tumors should be considered in a patient with a painful neck mass; a history of cervical spine surgery; and MRI findings showing a large, avidly enhancing, heterogeneous mass adjacent to surgical hardware that is hyperintense on T2-weighted imaging.

  6. Duodenum-derived fibromatosis that invaded the muscular layer of intestinal wall: A rare case report.

    Science.gov (United States)

    Li, Jiannan; Le, Hanxiang; Chai, Wei; Zhou, Yan; Jin, Lifang; Liu, Tongjun; Zhang, Kai

    2017-08-01

    Intraabdominal fibromatosis is a rare benign tumor that often affects the mesentery or retroperitoneum, and can infiltrate adjacent organs. However, it is rare for fibromatosis to arise from the small intestinal wall. A 27-year-old female with a tangible abdominal tumor is described. The computed tomography (CT) scan revealed a 7.5 cm, small intestine-associated tumor in the right abdomen. The patient received tumor resection and intestinal anastomosis. Further pathological examination confirmed the tumor as a duodenal fibromatosis that infiltrated the intestinal wall. To the best of our knowledge, this is the first report of a duodenum-derived fibromatosis that invaded the muscular layer of the intestine. Our study demonstrated that an unexplained abdominal mass should be noteworthy and properly treated.

  7. Fibromatosis arising in association with neuromuscular hamartoma of the mandible.

    Science.gov (United States)

    Taher, Leena Yaseen; Saleem, Muhammad; Velagapudi, Suresh; Dababo, Anas

    2013-09-01

    Aggressive fibromatosis is a benign but locally-aggressive tumor, which most often affects the muscles of the shoulder, the pelvic girdle, and the thigh. It usually affects adolescents and young adults. Desmoplastic fibroma, considered the bone counterpart of soft tissue fibromatosis, is a rare tumor that usually affects the metaphyseal or diaphyseal portions of long bones or, less commonly, the jaw. Neuromuscular hamartoma, a rare developmental lesion composed of mature elements of both striated muscle and nerve, is usually diagnosed in infants and children and affects large nerve trunks. Rarely, it can affect the head and neck region. Occasional cases showing an association between aggressive fibromatosis and neuromuscular hamartoma have been reported in the literature. Here we present a unique case of an adult patient with desmoplastic fibroma of the mandible in association with neuromuscular hamartoma.

  8. When is a GIST not a GIST? A case report of synchronous metastatic gastrointestinal stromal tumor and fibromatosis

    Directory of Open Access Journals (Sweden)

    Desilva Keshani

    2009-01-01

    Full Text Available Abstract Background A number of non-malignant diseases that share similar morphological features as gastrointestinal stromal tumor (GIST have been reported. Co-existence of GIST with these other diseases is rarely recognized or reported. Case presentation We report a case of a 62 year-old man with long-term stable control of metastatic GIST with systemic therapy, presented with an apparent intra-abdominal progression but not supported by imaging with positron emission tomography. Subsequent resection of the intra-abdominal tumor identified a non-malignant fibroid. Conclusion Differentiating localized progression of GIST from other diseases has important prognostic and therapeutic implications. The potential for co-existence of non-malignant soft tissue neoplasm should always be considered.

  9. [Plantar fibromatosis and Dupuytren's contracture in an adolescent].

    Science.gov (United States)

    Nikolić, Jelena; Janjić, Zlata; Momcilović, Dragan; Ninković, Srdjan; Harhai, Vladimir

    2011-10-01

    Fibromatosis represents a wide group of benign, locally proliferative disorders of fibroblasts. Dupuytren's disease is a benign proliferative disease of palmar aponeurosis which usually affects adults between 40 and 60 years of age. Ledderhose's disease or plantar fibromatosis is plantar equivalent of Dupuyten's disease most often affecting middle-aged and older men, usually bilateral, represented with painless nodule in the medial division of plantar fascia. We presented a 19-year old adolescent that turned to a plastic surgeon complaining to his small finger contracture. He noticed palmar thickening with nodule over the metacarpophalangeal joint of small finger of his right hand when he was 16 years old. A year later a finger started to band. During physical checkup we noticed plantar nodule that also had his father and grandmother. Magnetic resonance and tumor biopsy confirmed a suspicion on plantar fibromatosis - Ledderhose's disease. Clinical exam of the hand clearly led to a conclusion that the patient had Dupuytren's contracture with pretendinous cord over the small finger flexor tendons and lack of extension of proximal interphalangeal (PIP) joint. On the extensor side of the PIP joints there were Garrod's nodes. The patient refused surgical treatment of plantar tumor, but agreed to surgical correction of finger contracture. Despite the fact that Dupuytren's disease and plantar fibromatosis are diseases of adults, the possibility of conjoint appearance of these forms of fibromatosis in adolescent period of life should be kept in mind especially in patients with strong genetic predisposition.

  10. Idiopathic gingival fibromatosis

    Directory of Open Access Journals (Sweden)

    Sujata Rath

    2011-01-01

    This article presents a case report of a 14-year-old female patient with idiopathic gingival fibromatosis in the maxillary region with radiographic feature of congenitally missing maxillary permanent left lateral incisor, maxillary left and right permanent canine, mandibular right second premolar, all third molars along with overretained primary maxillary left lateral incisor and primary mandibular second molar. The treatment rendered in this patient comprised of surgical excision of the hyperplasia under general anesthesia.

  11. Fibromatosis of the cervical region following laminectomy: a case report and literature review.

    Science.gov (United States)

    Sevak, Shruti; Blount, Andrew L; Cottingham, Sandra; DeLano, Mark; Vander Woude, Douglas L; Stevenson, John; Chung, Mathew H

    2012-04-01

    A case report and a discussion of recently published data. To highlight the occurrence of postoperative fibromatosis arising in the cervical spine. Fibromatosis is a benign, locally invasive fibroblastic proliferation that can cause compressive effects on adjacent structures. Although the precise etiology of fibromatosis remains unclear, numerous studies have investigated the role of pluripotent mesenchymal stem cells in β-catenin-regulated tumorigenesis. At present, aggressive fibromatosis is managed with wide local excision. Postoperative radiation therapy is indicated for incomplete excision. A 48-year-old woman presented with a 2-year history of enlarging paracervical fibromatosis after undergoing extensive cervicothoracic instrumentation for excision of an extradural schwannoma. The patient underwent wide local excision of the neck mass, with right trapezius myocutaneous flap reconstruction of the subsequent defect. Histologically, the lesion was shown to be fibromatosis. Six months postoperatively, the patient was doing well with no recurrence. Fibromatosis is an important diagnosis to consider when evaluating locally aggressive spinal lesions at sites of prior operative repair. Molecular and genetic studies pertaining to the role of mesenchymal stem cells and β-catenin in the pathogenesis of aggressive fibromatosis tumors could lead to possible worthwhile treatment strategies in the future.

  12. Recurrent Primary Fibromatosis in the Breast: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Soo Jin; Kang, Young Hae; Lee, Ju Won; Kim, Youn Jeong [Dept. of Radiology, Inha University Hospital, Inha University School of Medicine, Incheon (Korea, Republic of); Kim, Lucia [Dept. of Pathology, Inha University Hospital, Inha University School of Medicine, Incheon (Korea, Republic of); Cho, Young Up [Dept. of Surgery, Inha University Hospital, Inha University School of Medicine, Incheon (Korea, Republic of)

    2012-03-15

    Fibromatosis is a rare benign tumor that presents predominantly as a unilateral, painless, palpable, and firm to hard mass which may be accompanied by skin dimpling and nipple retraction. It is characterized as an infiltrating fibroblastic and myofibroblastic proliferation that can behave in a locally aggressive fashion if incompletely excised. However, it is not known to metastasize. We report a case of a 39-year-old female with recurrent fibromatosis in the breast. Initially, the mass was detected by a screening mammography. It appeared as an oval mass and recurred twice after surgical excision over a 36-month period with a more suspicious appearance.

  13. [Expression of beta-catenin and estrogen receptor in desmoid-type fibromatosis].

    Science.gov (United States)

    Zhang, Hong-Ying; Ke, Qi; Zhang, Zhang; Zhang, Rui; Fu, Jing; Chen, Hui-Jiao; Wei, Bing; Bu, Hong

    2010-01-01

    To detect the expression of beta-catenin and Estrogen Receptor in desmoid-type fibromatosis. Nuclear beta-catenin expression was detected by immunohistochemistry in 77 lesions with desmoid-type fibromatosis and 171 other spindle cell lesions, including superficial fibromatosis (n = 18), nodular fasciitis (n = 36), keloid (n = 16), scar (n = 10), granulation tissue (n = 9), synovial sarcoma (n = 38), neufibroma (n = 13), solitary fibrous tumor (n =12), gastrointestinal stromal tumor (n = 10), low-grade myxofibrosarcoma (n = 3), low-grade fibromyxoid sarcoma (n = 3), and smooth muscle tumor (n = 10). In addition, the immunohistochemical expressions of ER-alpha, ER-beta and Ki-67 were examined in all of the lesions with desmoid-type fibromatosis. The nuclear immunohistochemical staining for nuclear beta-catenin and ER-beta was graded as high level ( > or = 25% of cells), low level (5%-25%) or none. High-level nuclear beta-catenin staining was detected in a very limited subset of tissue types, which included 70.1% of lesions with desmoid-type fibromatosis (54/77) and 6.3% of lesions with keloid (1/16). No high-level nuclear beta-catenin staining was seen in any of the other lesions. None of the lesions with desmoid-type fibromatosis expressed ER-alpha. However, 62 (80.5%) of the lesions with desmoids-type fibromatosis were positive in ER-beta, which included 52 (67.5%) with high-level expression, and 10 (13%) with low-level expression. The Spearman correlation analysis suggested that the expression of beta-catenin was positively correlated (r = 0.867, P fibromatosis had very low Ki-67 positive rate. The recurrence of desmoids-type fibromatosis was not correlated independently with beta-catenin, ER-beta or Ki-67. High-level nuclear beta-catenin staining serves as a useful diagnostic tool for desmoid-type fibromatosis. The high expression of ER-beta in desmoid-type fibromatosis provides a biological mechanism for the antiestrogenic compounds to treat fibromatosis. There

  14. [Clinical features and surgical treatment of chest aggressive fibromatosis].

    Science.gov (United States)

    Zhang, Y J; Gao, Y S

    2016-03-23

    To investigate the clinical features and surgical treatment of chest aggressive fibromatosis. Twenty-five patients with aggressive fibromatosis treated from September 1998 to May 2014 in the Department of Thoracic Surgery of Cancer Hospital of Chinese Academy of Medical Sciences were included in this study. The 25 patients, including 12 males and 13 famales, had an average age of 38 (range 15-76 years). The initial manifestations included chest pain (9 patients, 36.0%) and shortness of breath (1 patient). In 13 patients (52.0%) the tumor was found in a physical examination. Two patients (8.0%) were detected during an operation for lung disease. The tumor was located in the left chest wall in 15 patients, and located on the right side in 10 patients. Among them, the most common locations were the left front chest wall and the right front chest wall. The operation method affects the prognosis. Radiological imaging and needle biopsy did not make a correct diagnosis, and the diagnosis of aggressive fibromatosis was confirmed by pathology using immunohistechmistry after surgery. 13 patients underwent tumor resection, 9 cases had expanded resection, 3 patients had palliative resection. Six cases received radiotherapy after surgery. The median follow-up time was 101.5 months. Currently, all of the 25 patients are still alive, but 5 cases had local recurrence after surgery, among them, 4 patients received tumor resection, and one patient underwent expanded resection. Aggressive fibromatosis is a low-grade malignant tumor. The diagnosis of aggressive fibromatosis needs to be confirmed by pathology using immunohistechmical staining after surgery. Although this tumor is liable to relapse, its prognosis is favorable. Radical surgery is the most important treatment for patients to get a higher quality of life and long-term survival without recurrence.

  15. Idiopathic gingival fibromatosis

    Directory of Open Access Journals (Sweden)

    Nitin Hemchandra Dani

    2015-01-01

    Full Text Available Idiopathic gingival fibromatosis (IGF is a rare hereditary condition characterized by slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva caused by increase in submucosal connective tissue elements, mostly associated with some syndrome. This case report describes a case of nonsyndromic generalized IGF in an 18-year-old male patient who presented with generalized gingival enlargement. The enlarged tissue was surgically removed by internal bevel gingivectomy and ledge and wedge procedure. The patient was regularly monitored clinically for improvement in his periodontal condition as well as for any recurrence of gingival overgrowth.

  16. Idiopathic gingival fibromatosis

    Science.gov (United States)

    Dani, Nitin Hemchandra; Khanna, Dinkar Parveen; Bhatt, Vaibhavi Hitesh; Joshi, Chaitanya Pradeep

    2015-01-01

    Idiopathic gingival fibromatosis (IGF) is a rare hereditary condition characterized by slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva caused by increase in submucosal connective tissue elements, mostly associated with some syndrome. This case report describes a case of nonsyndromic generalized IGF in an 18-year-old male patient who presented with generalized gingival enlargement. The enlarged tissue was surgically removed by internal bevel gingivectomy and ledge and wedge procedure. The patient was regularly monitored clinically for improvement in his periodontal condition as well as for any recurrence of gingival overgrowth. PMID:26941525

  17. [Isolated Ledderhose fibromatosis plantaris].

    Science.gov (United States)

    Runkel, N; Göhring, U; Friedl, W; Roeren, T

    1993-07-01

    Plantar fibromatosis or Ledderhose syndrome has rarely been discussed in the medical literature. This clinical entity includes nodular Dupuytren-like indurations of the plantar aponeurosis. We present a case of a young man with isolated disease of his right foot and describe the clinical and pathomorphological features of this disease as well as its characteristic findings at magnetic resonance tomography. The therapy of choice is a subtotal resection of the plantar aponeurosis to prevent irreversible contractions of the toes. The prognosis following fascietomy is good.

  18. Juvenile hyaline fibromatosis.

    Science.gov (United States)

    Larralde, M; Santos-Muñoz, A; Calb, I; Magariños, C

    2001-01-01

    Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disease with onset in infancy or early childhood. It is characterized by papulonodular skin lesions, soft tissue masses, gingival hypertrophy, and flexion contractures of the large joints. The light and electron microscopic features are very distinctive. Here we report an 8-month-old boy with characteristic stiffness of the knees and elbows and pink confluent papules on the paranasal folds, and periauricular and perianal regions. He also had hard nodules all over the scalp and around the mouth, and severe gingival hypertrophy. Histologic and ultrastructural features were typical of JHF. Clinical features, pathology, and physiology are discussed.

  19. Juvenile hyaline fibromatosis: a case report.

    Science.gov (United States)

    Karaçal, Naci; Gülçelik, Nevzat; Yildiz, Kadriye; Mungan, Sevdegül; Kutlu, Necmettin

    2005-07-01

    Juvenile hyaline fibromatosis ( JHF ) is a rare autosomal recessive disease characterized by papulonodular skin lesions, gingival hyperplasia, joint contractures, and bone lesions. The skin lesions may consist of multiple large tumors, commonly on the scalp and around the neck, and small pearly, pink papules and plaques on the trunk, chin, ears, and around the nostrils. Here, we report a 2-year-old boy with characteristic stiffness of the knees and elbows and pink confluent papules on the paranasal folds, and periauricular and perianal regions. He also had hard nodules all over the scalp and around the mouth, and severe gingival hyperplasia. The lesions were totally excised and clinicopathological diagnosis was JHF.

  20. Infantile desmoid-type fibromatosis with involvement of temporal bone: case report

    Energy Technology Data Exchange (ETDEWEB)

    Hagen, T. [Dept. of Neuroradiology, Saarland Univ., Homburg (Germany); Feiden, W. [Dept. of Neuropathology, Saarland Univ., Homburg (Germany); Piepgras, U. [Dept. of Neuroradiology, Saarland Univ., Homburg (Germany)

    1995-12-31

    Infantile desmoid-type fibromatosis is a rare, benign, infiltratively growing tumor of the soft tissue. The histological classification is often confusing due to various patterns. Although surgical excision is the treatment of choice, local recurrence is high. Ultrasound, CT, and MRI cannot differentiate the different types of fibrous lesions, but are very essential, showing the localization and infiltrated tissues. We report an unusual case of desmoid-type fibromatosis destroying the temporal bone in a now-5-year-old boy. The literature contains only few reports of radiological findings in patients with infantile fibromatosis. (orig.)

  1. Aggressive fibromatosis of the oral cavity in a 5 year old boy: a rare case report

    Science.gov (United States)

    Nair, Keerthi Krishnankutty; Chaudhuri, Kanad; Lingappa, Ashok; Shetty, Ranjani; Vittobarao, Pramod Gujjar

    2017-01-01

    Fibrous tissue proliferations express a wide spectrum of histologic and morphologic variation in both infants and adults. This ranges from hypertrophic scar formation at one end to malignant fibrosarcoma at the other end of the spectrum. Aggressive fibromatosis is an intermediate tumor which is in proximity to fibrosarcomas. These are locally invasive and often recur after excision, but do not metastasize. Histologically, they are characterized by proliferating fibroblasts with little mitotic activity. Aggressive fibromatosis in the head and neck region is not common, and very sporadically occurs in the oral cavity or jaw bones. Here we report a rare case of aggressive fibromatosis occurring in a 5 year old boy. PMID:28819469

  2. Scintigraphic evaluation of aggressive fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, H.; Endo, K.; Konishi, J.; Iwasaki, R.; Kotoura, Y.; Yamamuro, T.; Kotoura, H. (Wakayama Red Cross Hospital (Japan))

    1990-10-01

    Despite its benign microscopic appearance, aggressive fibromatosis has potential to recur and infiltrate neighboring tissues. Therefore, it is necessary to determine the exact extent before therapy. In the present study, 11 cases of aggressive fibromatosis were examined scintigraphically using ({sup 99m}Tc(V))dimercaptosuccinic acid (11 cases) and {sup 67}Ga-citrate (7 cases). Technetium-99m-(V)-dimercaptosuccinic acid demonstrated all lesions, while {sup 67}Ga-citrate detected 57% of the cases.

  3. Radiological diagnosis of aggressive fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Wiesmann, W.; Galanski, M.; Peters, P.E.; Timm, C.

    1986-11-01

    Aggressive fibromatosis (desmoid, desmoid tumour) resembles, in its infiltrating and destructive growth, a fibrosarcoma, but does not metastasise. Because of its high recurrence rate, the tumour remains a surgical problem. Various imaging methods were evaluated retrospectively in 23 patients with histologically confirmed aggressive fibromatosis. Conventional radiological procedures are poor at demonstrating the extent and type of tumour. Modern tomographic methods are more able to determine the size of the lesion and a combination of angiography and CT can frequently provide a definite diagnosis.

  4. A Case Of Sporadic Mesenteric Fibromatosis Mimicking Pancreatic Mass

    Directory of Open Access Journals (Sweden)

    Halil ibrahim Tasci

    2015-03-01

    Full Text Available The term abdominal fibromatosis refers to sporadic, pelvic, and mesenteric lesions and to all the fibromatosis lesions seen in Gardner's syndrome. Sporadic fibromatosis, however, is very rarer and literature offers a limited number of cases. The 14-year-old female patient presented to our clinic with complaints of indefinite abdominal pain in the epigastric area for the last 2 months, dyspeptic problems, and vomiting after eating. Upon the patient's gastroscopy revealed a mass lesion pressuring the stomach, endoscopic ultrasonography was performed. A hyperechoic mass lesion of 9x5 cm thought to have originated from the pancreatic tail was detected. The mass was surgically excised. Although mesenteric fibromatosis shows the characteristics of a benign tumor pathologically, it is extremely aggressive clinically and has a very high rate of recurrence. These patients should be treated like they have malign tumors and surgeons should perform surgical resection as wide as possible. [Cukurova Med J 2015; 40(1.000: 138-142

  5. Desmoid Type Fibromatosis in the Facet Joint of Lumbar Spine: Case Report and Review of Literature

    Science.gov (United States)

    Kim, So Jung; Lee, Sang Min; Kang, Haeyoun

    2013-01-01

    Desmoid type fibromatosis is a benign fibroblastic tumor arising from the fascia or musculoaponeurosis. It may occur in various locations, but most commonly in the shoulder girdle and neck; to our knowledge, there has been no reported case originating from a facet joint of the spine. We report CT and MR imaging findings of a desmoid type fibromatosis, involving the facet joint of the L3-4 spine with bone involvement. PMID:24043979

  6. Desmoid type fibromatosis in the facet joint of lumbar spine: Case report and review of literature

    Energy Technology Data Exchange (ETDEWEB)

    Kim, So Jung; Ha, Doo Hoe; Lee, Sang Min; Kang, Hae Youn [CHA Bundang Medical Center, CHA University, Seongnam (Korea, Republic of)

    2013-10-15

    Desmoid type fibromatosis is a benign fibroblastic tumor arising from the fascia or musculoaponeurosis. It may occur in various locations, but most commonly in the shoulder girdle and neck; to our knowledge, there has been no reported case originating from a facet joint of the spine. We report CT and MR imaging findings of a desmoid type fibromatosis, involving the facet joint of the L3-4 spine with bone involvement.

  7. Aggressive fibromatosis of the mandible in childhood

    Energy Technology Data Exchange (ETDEWEB)

    Sartoris, D.J.; Parker, B.R.; Arkoff, R.S.

    1983-09-01

    Aggressive fibromatosis, or infantile fibrosarcoma, is an uncommon form of juvenile fibromatosis which rarely involves the head and neck. Skeletal involvement is infrequently demonstrated by radiography in this condition. Two unusual cases with similar radiographic changes in the mandible are presented, a situation not previously described. Clinical, pathologic, and radiographic features of aggressive fibromatosis are discussed.

  8. Juvenile hyaline fibromatosis

    Directory of Open Access Journals (Sweden)

    Jayashree Krishnamurthy

    2011-01-01

    Full Text Available Juvenile hyaline fibromatosis is a rare, autosomal-recessive disease characterized by papular and nodular skin lesions, gingival hyperplasia, joint contractures and bone involvement in variable degrees. It is a connective tissue disorder with aberrant synthesis of glycosaminoglycans by fibroblasts. We report a 5-year-old female born of first-degree consanguineous marriage who presented with multiple, recurrent, painless, variable-sized nodules. Fine needle aspiration cytology smears and the subsequent histopathological examination from the nodules showed benign spindle cells in a Periodic acid Schiff-positive myxoid background. The disease has a relentlessly progressive course, with most patients surviving only up to the 4 th decade. As of now, there is no specific treatment for this disorder. Genetic counseling is essential to explain to parents about a 25% chance of having a diseased baby in any pregnancy. With the gene being mapped recently, techniques for antenatal diagnosis are likely to be established.

  9. Plantar fibromatosis. Ultrasound assessment; La fibromatosi plantare: risultati ecografici

    Energy Technology Data Exchange (ETDEWEB)

    Solivetti, F.R.; Luzi, F.; Bucher, S.; Thorel, M.F.; Muscardin, L. [Rome Ospedale Santa Maria e San Gallicano, Rome (Italy)

    1999-05-01

    In 1998-99, six patients with plantar fibromatosis were submitted to US (ultrasound) with plantar fibromatosis were submitted to US with 13 MHz linear array and 20 MHz mechanical annular array probes. All patients were examined in prone recumbency with the probe positioned on the sole of the foot. Only some of them were subsequently submitted to surgery. Plantar fibromatosis exhibited an almost pathognomonic pattern and US proved to be a quick, noninvasive and cost-effective technique to confirm clinical diagnosis. The nodule is typically single and iso echoic, with maximum diameter of about 1 cm, inhomogeneous internal structure and few thin hyperechoic septa. The nodular fibrous proliferation adheres with the major axis along the plantar fascia; it exhibits clear-cut margins and US beam transmission is good. No calcifications or fluid collections are seen within the nodule. Color and power Doppler show no flow inside. It is demonstrated that US is an adequate tool for the study of plantar fibromatosis. [Italian] Negli anni 1998-99 sono stati osservati ben sei casi di fibromatosi plantare, solo in parte trattati chirurgicamente. Tutti sono stati studiati con ecografia, con apparecchiatura in tempo reale e sonde lineari da 13 MHz e anulari da 20 MHz. Si puo' descrivere un quadro tipico della malattia diagnosticabile con l'ecografia, specie in associazione con sintomi clinici caratteristici.

  10. Plantar fibromatosis and Dupuytren’s contracture in an adolescent

    Directory of Open Access Journals (Sweden)

    Nikolić Jelena

    2011-01-01

    Full Text Available Background. Fibromatosis represents a wide group of benign, locally proliferative disorders of fibroblasts. Dupuytren` s disease is a benign proliferative disease of palmar aponeurosis which usually affects adults between 40 and 60 years of age. Ledderhose`s disease or plantar fibromatosis is plantar equivalent of Dupuyten`s disease most often affecting middle- aged and older men, usually bilateral, represented with painless nodule in the medial division of plantar fascia. Case report. We presented a 19-year old adolescent that turned to a plastic surgeon complaining to his small finger contracture. He noticed palmar thickening with nodule over the metacarpophalangeal joint of small finger of his right hand when he was 16 years old. A year later a finger started to band. During physical checkup we noticed plantar nodule that also had his father and grandmother. Magnetic resonance and tumor biopsy confirmed a suspicion on plantar fibromatosis - Ledderhose`s disease. Clinical exam of the hand clearly led to a conclusion that the patient had Dupuytren`s contracture with pretendinous cord over the small finger flexor tendons and lack of extension of proximal interphalangeal (PIP joint. On the extensor side of the PIP joints there were Garrod`s nodes. The patient refused surgical treatment of plantar tumor, but agreed to surgical correction of finger contracture. Conclusion. Despite the fact that Dupuytren`s disease and plantar fibromatosis are diseases of adults, the possibility of conjoint appearance of these forms of fibromatosis in adolescent period of life should be kept in mind especially in patients with strong genetic predisposition.

  11. Juvenile hyaline fibromatosis. Radiological diagnosis. Fibromatosis hialina juvenil. Diagnostico radiologico

    Energy Technology Data Exchange (ETDEWEB)

    Fuentes, R.; Sar, V.; Cabrera, J.J.; Diaz, L.; Hernandez, B.; Valeron, P.; Baez, O.; Rodriguez, M.

    1993-10-01

    Juvenile hyaline fibromatosis (JHF) is a rare disorder of unknown etiology, very few cases of which have been reported in the literature. It presents similarities to other fibromatosys, but has its particular radiological features which differentiate it from them. The clinical findings consist of several, slow growing, subcutaneous nodules, flexion contractures of the joints which can lead to disability, gingival hypertrophy and muscular atrophy. The suspected radiological diagnosis is confirmed by electron microscopy study of the nodules, although light microscopy can also reveal suggestive images. Author (9 refs.)

  12. Fibromatosis of breast mimicking sarcoidosis

    Directory of Open Access Journals (Sweden)

    Silonie Sachdeva

    2011-01-01

    Full Text Available Primary mammary fibromatosis is a rare skin condition which can arise after trauma or previous surgery. The exact etiology is unknown. Very few cases have been reported in literature and the main emphasis is to differentiate this condition from breast carcinoma. We report here an unusual case of a 60 year old female who presented with skin lesion which clinically looked sarcoid with history suggestive of sarcoidosis, but on histopathology fibromatosis of breast was revealed. Complete work up ruled out any carcinomatous changes. Surgical excision of the lesion was done with no recurrence seen in one year follow up period.

  13. Low-grade fibromyxoid sarcoma versus fibromatosis: a comparative study of clinicopathological and immunohistochemical features.

    Science.gov (United States)

    Meng, Guo-Zhao; Zhang, Hong-Ying; Bu, Hong; Geng, Jian-Guo

    2009-02-01

    We have studied 11 cases of low-grade fibromyxoid sarcoma (LGFMS) and 15 cases of fibromatosis with respect to clinicopathological features and immunohistochemical expression of Ki-67, nm23, cyclinD1, and p53, in order to investigate the differential diagnosis between this two groups. Formalin-fixed, paraffin-embedded sections from 11 cases of LGFMS and 15 cases of fibromatosis were studied histologically and immunohistochemically. The immunostainings were semiquantitatively evaluated using the Allred score system. Microscopically, LGFMS was composed of bland spindle cells arranged in a whorled pattern showing alternating myxoid zones and fibrous stroma zones with prominent arcade curvilinear capillaries. Cytological atypia, mitotic figures, and tumor necrosis were absent in all 11 cases of LGFMS. In contrast, fibromatosis was less cellular and more fascicular, containing more collagen and showing no alternating fibrous and myxoid zones as compared with LGFMS. The immunostaining scores of nm23 in LGFMS were significantly lower than that in fibromatosis. The immunostaining scores of Ki-67, p53, and cyclinD1 in LGFMS were significantly higher than that in fibromatosis. Thus, we consider that LGFMS can be distinguished from fibromatosis by clinicopathological features, and assessments of the immunohistochemical expression level of cyclinD1, p53, nm23, and Ki-67 are helpful in the differential diagnosis.

  14. Fibromatosis of bone in children

    Energy Technology Data Exchange (ETDEWEB)

    Capusten, B.M.; Azouz, E.M.; Rosman, M.A.

    1984-09-01

    Radiographs, computed tomograms, and radionuclide bone scans were obtained preoperatively in three children with fibromatosis involving the bones and soft tissues of the extremities. Two of the children had identical scar-like bone lesions of the proximal tibia, which, to the author's knowledge, have not been reported before in this disease. The lesions recurred in two children.

  15. Hyaline fibromatosis syndrome: cutaneous manifestations*

    Science.gov (United States)

    Marques, Silvio Alencar; Stolf, Hamilton Ometto; Polizel, Juliana Ocanha; Munhoz, Tânia; Brandão, Marcela Calixto; Marques, Mariangela Esther Alencar

    2016-01-01

    Hyaline fibromatosis syndrome is the current name for clinical manifestations of diseases previously known as “infantile systemic hyalinosis” and “juvenile hyaline fibromatosis”. The authors report representative clinical cases of each one of the above subtypes with emphasis on cutaneous manifestations and difficulties for early diagnosis in this syndrome, essentially of multidisciplinary approach. PMID:27192526

  16. Mammary fibromatosis in a male breast.

    Science.gov (United States)

    Al-Saleh, N; Amir, T; Shafi, I N

    2012-07-01

    Fibromatosis of the breast is a relatively benign, though locally invasive neoplasm. It is rare and difficult to diagnose. Risk of recurrence is there if it was inadequately excised. The best treatment is local wide excision with negative margins. We report a 46-year old gentleman with mammary fibromatosis. To the best of our knowledge, there are only few cases reported on male breast fibromatosis. The optimal management of it is unknown because of the rarity of the disease.

  17. Radiologic images of an aggressive implant-associated fibromatosis of the breast and chest wall: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Lourdes Alanis, MD, MPH

    2017-09-01

    Full Text Available Fibromatosis of the breast is a rare benign disease compromising <0.2% of all primary breast tumors. Although the chest wall is a common location, occurrences of implant-associated fibromatosis of the breast are extremely rare; only 33 cases have been reported. We present a case of a 42-year-old female who underwent breast augmentation with silicone breast implants, and 2 years later developed an aggressive implant-associated fibromatosis of the breast and chest wall. On imaging studies, the tumor mimicked breast carcinoma, and despite chemotherapy, the fibromatosis rapidly enlarged and was locally invasive requiring wide surgical excision. Unlike previously reported imaging findings, magnetic resonance imaging revealed an oval circumscribed mass with fringe-like internal architecture. We provide a review of the literature and discuss the imaging features of implant-associated fibromatosis of the breast.

  18. [A little known entity: aggressive fibromatosis].

    Science.gov (United States)

    Marqúes Gubern, A; Pérez Payarols, J; Sánchez de Toledo, J; Martínez Ibáñez, V; Moraga, F; de Torres Ramírez, I M

    1991-01-01

    Aggressive fibromatosis is an unfrequent and little known entity, which in spite of being a histologically benign tumoration with scarce mitosis and without metastasis at distance, frequently presents with a high degree of local malignancy that can cause serious functional and aesthetical disturbance for the patient and even lead to death if infiltration of vital organs is presented, above all in cases of abdominal or maxillo-facial mass localization. The authors present their experience with 17 cases of aggressive fibromatosis observed in our centre: four of abdominal localization, six in extremities, five in the maxillo-facial mass, one in the torax and one in the lumbo-sacral region. Histological diagnosis, either by puncture or biopsy, is complemented by studies of extension of the tumour based on ecography and TAC. All cases were treated according to the classical criteria of ample resection of the lesion, always when practicable, except in one infant case and in the torax, in which only a biopsy was effected. Of the 15 cases resected, nine cases had local relapses, six of which remained free of disease with a second operation, another two required a third operation and the remaining case needed five interventions. In six children chemotherapy was applied with vincristina, cyclophosphamide and adriamicina. A follow up was carried out in 14 patients, one of which died and the remaining 13 are free of disease. In spite of the fact that progestagene receptors were not evidenced in two of our cases, one presented complete remission of the tumor after treatment with medroxyprogesterone. In this case the coincidence of Gardner's syndrome arises in the family history.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. Aggressive fibromatosis: evaluation by computed tomography and angiography

    Energy Technology Data Exchange (ETDEWEB)

    Hudson, T.M.; Vandergriend, R.A.; Springfield, D.S.; Hawkins, I.F. Jr.; Spanier, S.S.; Enneking, W.F.; Hamlin, D.J.

    1984-02-01

    Fifteen CT scans of 13 patients who had aggressive fibromatosis were generally accurate in showing the extent of disease, although the CT definition of half or more of the margins of nine lesions was poor. Fibromatosis tumors were typically isodense or slightly hypodense with muscle when no contrast medium was used, and they enhanced to hyperdense with better delineation during infusion of contrast medium. Obliterated intermuscular planes did not always signify disease extension; the relationship to bone was often obscured by beam-hardening artifact; and small blood vessels were often invisible. Arteriograms of seven of eight patients showed some hypervascularity and helped to delineate lesions and vessels that were poorly seen on CT scans. In four instances CT findings were clearer, in two instances arteriographic findings were clearer, and twice the findings were equally clear. Three of six bone scintigrams added accurate information about involvement of adjacent bones.

  20. Sclerotome distribution of melorheostosis and multicentric fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Rhys, R. [Department of Radiology, Royal Orthopaedic Hospital NHS Trust, Birmingham (United Kingdom); Davies, A.M. [Department of Pathology, Royal Orthopaedic Hospital NHS Trust, Birmingham (United Kingdom)]|[MRI Centre, The Royal Orthopaedic Hospital NHS Trust, Woodlands, Northfield, Birmingham (United Kingdom); Mangham, D.C. [Department of Pathology, Royal Orthopaedic Hospital NHS Trust, Birmingham (United Kingdom); Grimer, R.J. [Department of Orthopaedic Oncology, Royal Orthopaedic Hospital NHS Trust, Birmingham (United Kingdom)

    1998-11-01

    A case of melorheostosis affecting the C7 sclerotome is described, in association with synchronous multicentric fibromatosis. The foci of fibromatosis also affected the C7 sclerotome, suggesting a similar underlying pathogenesis for both diseases. (orig.) With 6 figs., 16 refs.

  1. Fibromatosis: a potential sequela of neuromuscular choristoma.

    Science.gov (United States)

    Hébert-Blouin, Marie-Noëlle; Scheithauer, Bernd W; Amrami, Kimberly K; Durham, Susan R; Spinner, Robert J

    2012-02-01

    Neuromuscular choristoma (NMC) is a rare peripheral nerve lesion in which mature skeletal muscle fibers lie within the nerve and its fascicles. Given limited follow-up, its natural history is poorly understood. The occurrence of aggressive fibromatosis in one of the authors' patients and its occurrence in reported cases suggests an etiological relationship between the 2 lesions. This study attempts to explain the association and its frequency. All cases of NMCs seen in consultation or treated at the Mayo Clinic were identified. Demographic and clinical data were reviewed in cases with coexistent aggressive fibromatosis. Pathology and neuroimaging studies were reexamined. In addition, an extensive literature review was performed to explore the association of NMC with aggressive fibromatosis, with special attention given to pathological and imaging characteristics and the development of aggressive fibromatosis. The authors identified 10 patients with a diagnosis of NMC who were treated at the Mayo Clinic between 1992 and 2010. Four of 5 with adequate follow-up had developed a definite or suspected aggressive fibromatosis. A review of the initial pathological specimens in these cases revealed no evidence of fibromatosis, but all of the lesions exhibited accompanying hypocellular collagenous tissue. On MR images, all cases showed areas of low signal intensity, which significantly differed from muscle, nerve, and NMC components. On available serial MR imaging studies, aggressive fibromatosis seemed to originate in such lower-intensity regions. In the 18 previously reported cases of NMC, 5 patients developed recurrent masses diagnosed as either definite (2 cases) or possible (3 cases) fibromatosis. Review of the published imaging studies in these cases suggests the presence of lower intensity areas similar to those observed in the 10 patients treated at the Mayo Clinic. This study confirms that the development of aggressive fibromatosis in patients with NMC has been

  2. Desmoid-type fibromatosis of the head and neck in children: a case report and review of the literature.

    Science.gov (United States)

    Miyashita, Hidetaka; Asoda, Seiji; Soma, Tomoya; Munakata, Kanako; Yazawa, Masaki; Nakagawa, Taneaki; Kawana, Hiromasa

    2016-06-10

    Desmoid-type fibromatosis is defined as an intermediate tumor that rarely occurs in the head and neck of children. There is no doubt as to the value of complete surgical excision for desmoid-type fibromatosis. However, in pediatric patients, surgeons may often be concerned about making a wide excision because of the potential for functional morbidity. Some studies have reported a lack of correlation between margin status and recurrence. Therefore, we discussed our findings with a focus on the state of surgical margins. We report an unusual case of a 9-month-old Japanese girl who prior to presenting at our hospital underwent debulking surgery twice with chemotherapy for desmoid-type fibromatosis of the tongue at another hospital. We performed a partial glossectomy and simultaneous reconstruction with local flap and achieved microscopic complete resection. We also reviewed available literature of pediatric desmoid-type fibromatosis in the head and neck. We described successful treatment for the refractory case of pediatric desmoid-type fibromatosis. The review results showed that some microscopic incomplete resections of tumors in pediatric patients with desmoid-type fibromatosis tended to be acceptable with surgical treatment.

  3. Breast fibromatosis response to tamoxifen: dynamic MRI findings and review of the current treatment options.

    Science.gov (United States)

    Plaza, Michael J; Yepes, Monica

    2012-03-01

    Breast fibromatosis is a rare entity responsible for 0.2% of all solid breast tumors. It has been associated with scars, pregnancy, implants, and familial adenomatous polyposis. We present an interesting case of breast fibromatosis in a 29 year old woman which encroached upon her saline implant and subsequently filled its cavity once the implant was removed. The patient was put on tamoxifen therapy and at 14 month follow-up there was a significant decrease in the size of the mass. Dynamic MRI images are offered for review and current treatment options are discussed.

  4. Fibromatosis of the breast mimicking an abscess: case report of unusual sonographic features.

    Science.gov (United States)

    Lee, So Min; Lee, Ji Young; Lee, Byung Hoon; Kim, Su Young; Joo, Mee; Kim, Jae Il

    2015-01-01

    Fibromatosis of the breast, also known as a desmoid tumor, is extremely rare and most often appears as an aggressive lesion mimicking breast carcinoma. It lacks metastatic potential but can grow aggressively in a localized area. Ultrasonography often shows an irregular spiculated hypoechoic mass with posterior acoustic shadowing. We discuss a case of breast fibromatosis that presented as a painful palpable breast mass in a 32-year-old woman and mimicked an abscess in the sonogram. We found that this lesion displayed atypical sonographic features such as a heterogeneous echoic mass with an internal anechoic area. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Infantile Fibromatosis: A Rare Cause of Anterior Mediastinal Mass in a Child

    Directory of Open Access Journals (Sweden)

    Venkatraman Bhat

    2015-01-01

    Full Text Available Fibromatosis also known as desmoid tumor is an uncommon cause of a mediastinal mass in patients of all ages. Imaging appearance of fibromatosis is generally nonspecific and demands special attention to subtle details to be correctly identified as a possibility. Management of the patient is often complicated by failure to obtain precise pre-operative diagnosis. Location of a mass in the anterior mediastinum with encasement of vital structures is not favourable for complete cure. Although histologically benign, biological behaviour of the lesion varies between benign fibrous proliferation and low-grade fibrosarcoma. We present imaging appearances, surgical management dilemma, and the histopathological details of a case of fibromatosis in the anterior mediastinum in a child.

  6. Squamous cell carcinoma of the lung with highly proliferating fibromatosis-like stroma: a rare phenomenon.

    Science.gov (United States)

    Tajima, Shogo; Takanashi, Yusuke; Koda, Kenji

    2015-01-01

    Few cases of carcinoma with exuberant stromal proliferation have been documented, apart from scirrhous carcinoma. To the best of our knowledge, previous cases of carcinoma exhibiting exuberant stromal proliferation have exclusively been reported in the thyroid gland, specifically as papillary carcinoma. The exuberant stromal proliferation has been recognized to be similar to either fibromatosis or nodular fasciitis. Herein, we report a case of a 74-year-old Japanese man whose tumor in the upper lobe of his right lung displayed highly proliferating stroma with dispersed, poorly differentiated squamous cell carcinoma nests. The stromal spindle cells (fibroblasts/myofibroblasts) had similar molecular profiles to those typically observed in fibromatosis rather than nodular fasciitis, resulting in the designation of "fibromatosis-like" stroma. The presence of carcinoma cells, along with stromal cells, expressing TGF-β in this case likely fostered continuous stromal proliferation, presumably in conjunction with the unique microenvironment in which the carcinoma cells were present.

  7. Magnetic resonance appearance of fibromatosis. A report of 14 cases and review of the literature

    Energy Technology Data Exchange (ETDEWEB)

    Kransdorf, M.J.; Jelinek, J.S.; Utz, J.A. (Walter Reed Army Medical Center, Washington, DC (USA). Dept. of Radiology Uniformed Services Univ. of the Health Sciences, Bethesda, MD (USA). Dept. of Radiology and Nuclear Medicine); Moser, R.P. Jr. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Radiologic Pathology Uniformed Services Univ. of the Health Sciences, Bethesda, MD (USA). Dept. of Radiology and Nuclear Medicine Pennsylvania State Univ., Hershey (USA). Dept. of Radiology); Hudson, T.M. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Radiologic Pathology); Neal, J. (Armed Forces Inst. of Pathology, Washington, DC (USA). Dept. of Soft Tissue Pathology); Berrey, B.H. (Walter Reed Army Medical Center, Washington, DC (USA). Dept. of Orthopedic Surgery Uniformed Services Univ. of the Health Sciences, Bethesda, MD (USA). Dept. of Surgery)

    1990-10-01

    We reviewed retrospectively the magnetic resonance (MR) images of 14 soft-tissue lesions of fibromatosis (desmoid tumors) encountered in 11 patients. The lesions were typically inhomogeneous in texture and round to oval in configuration. Margins were well-defined in 78% of the lesions at presentation and were infiltrating in all recurrences. (orig./DG).

  8. Aggressive musculo-apo neurotic fibromatosis, findings in image in a case of posttraumatic involvement of the scalene muscle; Fibromatosis musculo-aponeurotica agresiva, hallazgos en imagen en un caso de afectacion postraumatica dle musculo escaleno

    Energy Technology Data Exchange (ETDEWEB)

    Vizcaino, I.; Costa, S.; Cremades, A. [Hospital Universitario Dr. Peset. Valencia (Spain)

    2001-07-01

    Musculoaponeurotic fibromatosis is a well-differentiated benign tumoral condition of fibroblastic origin that is classified as a tumor of the soft tissue. These lesions present an intermediate biological behavior between the benign fibroblastic tumors and fibrosarcoma, and have the capacity of presenting local relapse, but never metastasis. One case of post-traumatic musculoaponeurotic fibromatosis of the scalene muscle is presented by the study of the ultrasonography, CT and MRI. The imaging findings are not characteristics, but they are useful to carry out the differential diagnosis and extension study. (Author) 14 refs.

  9. Fibromatosis orbitaria solitaria: reporte de caso

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    Jorge Docampo

    2010-04-01

    Full Text Available Se reporta un caso de fibromatosis orbitaria solitaria en una paciente de sexo femenino de 4 años de edad, la que acudió a consulta por proptosis derecha y pérdida de la agudeza visual. Por tomografía computada (TC, ecografía y resonancia magnética (RM se identificó una masa intraconal que comprometía a los músculos extrínsecos de la órbita y hacía impronta sobre el nervio óptico.Solitary fibrous tumor of the orbit. Case report We report on a 4-year-old female patient with solitary fibrous tumor of the orbit, who presented with right eye ptosis and loss of visual sharpness. Computed tomography (CT scan, ultrasonography (US and magnetic resonance imaging (MRI showed an intraconal mass lesion involving the extrinsic orbit muscles, leaving a depression on the aptic nerve.

  10. [Desmoid fibromatosis of the posterior mediastinum].

    Science.gov (United States)

    Ayadi-Kaddour, A; Chaabouni, N; Smati, B; Mehouachi, R; Djilani, H; El Mezni, F

    2008-01-01

    Fibromatosis are uncommon connective tissue tumours arising from musculo-aponeurotic tissue and characterised by spindle cell fibroblastic and myofibroblastic proliferation. The exact aetiology is unknown but several factors are considered to be positively correlated with their development and growth (genetic and hormonal factors and trauma). Although they are considered histologically benign they behave aggressively locally and relapse repeatedly after surgical excision. Mediastinal localisation is very rare. We describe a case of de novo fibromatosis of the posterior mediastinum in a 61 year old man with no history of thoracotomy or trauma. Although mediastinal fibromatosis is very uncommon physicians should be aware of this disease in order to ensure appropriate surgical treatment.

  11. Plantar fibromatosis: an immunohistochemical and ultrastructural study.

    Science.gov (United States)

    de Palma, L; Santucci, A; Gigante, A; Di Giulio, A; Carloni, S

    1999-04-01

    The analogies between plantar fibromatosis and Dupuytren's disease (palmar fibromatosis) are well known. The latter is clinically more frequent and has been the object of extensive immunohistochemical and ultrastructural studies, with a view to investigating its pathogenesis. By contrast, such data on plantar fibromatosis are quite scarce. A histochemical, immunohistochemical, and ultrastructural study was performed on nodule tissue from six patients who were subjected to total fasciectomy for plantar fibromatosis. The study of myofibroblasts revealed features suggestive of their fibroblastic origin and evidenced a cytoskeleton and an extracellular filamentous system that could enable myofibroblasts to generate and exert the intracellular forces that contribute to the contraction of the aponeurosis. These aspects are similar to those observed in Dupuytren's disease and seem to lend support to the theory that the two diseases are expressions of the same disorder.

  12. Case report: Fibromatosis colli in a neonate

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    Smiti S

    2010-01-01

    Full Text Available Fibromatosis colli or pseudotumor of infancy of the sternocleidomastoid muscle is a rare cause of a benign neck mass in neonates and infants. If diagnosed correctly, it can be managed conservatively, and unnecessary investigations can be avoided.

  13. Giant Omental Fibromatosis Presenting as Pelvic Mass

    Science.gov (United States)

    Singh, Pradyumn; Jain, Neelesh; Jain, Jaswant; Kumar, Vijay

    2015-01-01

    Omental fibromatosis (abdominal desmoids) is a rare benign but locally aggressive neoplasm characterized by mass like or infiltrative growth of fibrous tissue. It usually arises from the abdominal wall or the extremities, however rarely it may also arise in the omentum, ileocolic mesentery, transverse or sigmoid mesocolon and ligamentum teres. Here, we present an 18-year-old male, who presented with lower abdominal pain and palpable lump in hypogastric region. Computed tomography of the abdomen showed large heterogeneous mass in lower abdomen, possibly arising from mesentery with regional adenopathy. Patient underwent exploratory laparotomy with a preoperative diagnosis of mesenteric tumour possibly gastrointestinal stromal tumour (GIST). Histopathological examination revealed the lesion as omental fibromatosis. To the best of our knowledge, very few cases of omental fibromatosis are noted in literature. Here, we describe a rare case of giant omental fibromatosis which resembled mesenteric GIST clinically but finally diagnosed as fibromatosis by histomorphology and immunohistochemistry (IHC). The present article describes fibromatosis of greater omentum and the difficulty in preoperative diagnosis, as it is frequently misdiagnosed as GIST. PMID:25859511

  14. Desmoid-type fibromatosis-associated Gardner fibromas: prevalence and impact on local recurrence.

    Science.gov (United States)

    Cates, Justin M M; Stricker, Thomas P; Sturgeon, Duveen; Coffin, Cheryl M

    2014-10-28

    Although Gardner fibroma is a precursor lesion of desmoid tumor, the prevalence and prognostic importance of Gardner fibroma associated with desmoid tumors has not been systematically studied in adults. From 129 patients with desmoid-type fibromatosis, 170 specimens were re-examined for the presence of an associated Gardner fibroma. Clinicopathologic features of Gardner fibroma-associated desmoid-type fibromatosis were compared to desmoid tumors without associated Gardner fibroma. Recurrence-free survival was compared using multivariate Cox proportional hazard regression to account for known confounding factors. Of 104 evaluable primary desmoid tumor resections, 25 (24%) had an associated Gardner fibroma. When previous incisional biopsies and resection specimens of locally recurrent desmoid tumors were also examined, the overall prevalence of associated Gardner fibroma was 37%. Desmoid tumors arising in high risk anatomic sites (extremities or deep soft tissues of the back and chest wall) were more often associated with Gardner fibroma than tumors at other sites. Median recurrence-free survival for patients with Gardner fibroma-associated desmoid-type fibromatosis was 3.2 years, whereas median survival for patients without associated Gardner fibroma was >25 years (hazard ratio 2.8; P = 0.001). Although the presence of Gardner fibroma had no impact on the recurrence rate of desmoid tumors arising at high risk anatomic sites, associated Gardner fibroma increased the risk of recurrence 4-fold for desmoid tumors at low risk anatomic sites. Associated Gardner fibroma is under-recognized in desmoid-type fibromatosis and increases the risk of local recurrence for a subgroup of patients. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  15. F 18 FDG PET/CT Findings of Spontaneous Mesenteric Fibromatosis in a Patient with Gardner's Syndrome

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    Sohn, Myung Hee; Jeong, Young Jin; Lim, Seok Tae; Kim, Dong Wook; Jeong, Hwan Jeong; Yim, Chang Yeol [Chonbuk National Univ. Medical School and Hospital, Jeonju (Korea, Republic of)

    2011-06-15

    Gardner's syndrome (GS), a variant of familial adenomatous polyposis, is an autosomal dominant disease. Originally, Gardner described a syndrome consisting of hereditary intestinal polyposis With osteomas and multiple cutaneous and subcutaneous lesions. The syndrome was later modified by the addition of other features, such as dental abnormalities, abdominal fibromatosis, and a number of malignant tumors. the principal cutaneous lesions that have been described in GS are epidermoid cysts. Other cutaneous lesions include fibromas, lipomas, leiomyomas, neurofibromas, and pigmented skin lesions. Fibromatoses are histologically benign, but locally aggressive fibrous tumors consisting of mature fibroblasts within an extensive collagen matrix. Most cases are sporadic, but there is a clear association with familial adenomatous polyposis and GS, suggesting a link with a mutation of the APC gene on chromosome 5q22. Fibromatosis occurs in 3.5%-29% of patients with GS, and is more likely to be multiple and to involve the mesentery and abdominal wall rather than being an isolated form. Clinically, fibromatosis presents as a painless firm soft tissue mass. Most cases of fibromatosis are believed to be precipitated by surgical trauma, however, a few cases of spontaneous occurrence have been reported. In our patient, no history of abdominal surgery or trauma was present. In addition, an abdominal CT obtained 2 years ago revealed no abnormality. Although the radiological features of fibromatosis on CT or MR have been described in the literature, F 18 FDG PET or PET/CT findings are rarely reported. The F 18 FDG uptake in patients with fibromatosis ranged from low to moderate grade and was generally heterogenous with a few tiny foci of relatively intense uptake or relatively homogenous. The areas of higher FDG metabolism are likely to represent more cellular and mitotically active areas. Mesenteric fibromatosis has similar findings to extra abdominal lesions.

  16. Spinal fibromatosis: a report of two cases and review of the literature.

    Science.gov (United States)

    Shakur, Sophia F; Takagi, Ippei; Jacobsohn, Jamie A; Golden, Barbara M; Karahalios, Dean G

    2013-08-01

    Spinal fibromatosis is a unique subset of fibromatosis that is only anecdotally described in the literature in sporadic case reports. According to our review of the literature, only 11 cases of spinal fibromatosis have been previously documented. This paucity of clinical data limits our understanding of its presentation and treatment. The authors present the first two cases of spinal fibromatosis encountered at their institution, and review the literature of reported cases to elucidate the presentation and outcomes of patients with this rare tumor. A report of two cases and review of the literature. The two patients in our case report were women aged 45 and 38 years. Both of the patients presented to our clinic after previous excisional biopsy of a spinal mass, 17 years and 1 year later, respectively, with pain and paresthesias that recapitulated their former symptoms. Thirteen cases, including the two described in the current article, were culled from the literature. Magnetic resonance imaging revealed an enhancing lesion in the posterior elements of the spinal column in the first case and a paraspinal soft tissue mass in the second case. The tumors were histologically defined by haphazardly arranged, elongated, and slender spindle cells separated by abundant collagen without mitoses or necrosis. Surgical management resulted in intralesional resection in the first case and en bloc resection in the second case. By 40 and 10 months after surgery, both patients remain without neurologic deficits. Among 13 cases of spinal fibromatosis, pain with or without a mass is the most common symptom at presentation. Tumor etiology is evenly distributed between de novo origin and surgical trauma. Treatment outcomes, although, cannot be determined from the limited data currently available. Published by Elsevier Inc.

  17. Aggressive fibromatosis of the neck in a patient with Gardner's syndrome

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    Rai, A.T.; Nguyen, T.P.; Hogg, J.P.; Gabriele, F.J. [Dept. of Radiology, West Virginia Univ. Hospitals, Morgantown, WV (United States)

    2001-08-01

    We report a patient with Gardner's syndrome who, in addition to a total colectomy, had multiple excisions of desmoid tumors in both thighs. He presented with left-sided neck swelling and pain. MRI was highly suggestive of desmoid tumors in multiple neck muscles. To our knowledge this is the first description of diffuse fibromatosis of the neck in association with Gardner's syndrome. (orig.)

  18. The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor

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    Hashimoto, Yoshifumi; Kumagai, Naomichi; Hosoda, Nao; Hoshino, Shin-ichi, E-mail: hoshino@phar.nagoya-cu.ac.jp

    2014-03-14

    Highlights: • So far, eRF3 has been thought to function exclusively in the cytoplasm. • eRF3 is a nucleo-cutoplasmic shuttling protein. • eRF3 has a leptomycin-sensitive nuclear export signal (NES). • Removal of NES by proteolytic cleavage allows eRF3 to translocate to the nucleus. • The processed eRF3 (p-eRF3) interacts with a nuclear tumor suppressor ARF. - Abstract: The eukaryotic releasing factor eRF3 is a multifunctional protein that plays pivotal roles in translation termination as well as the initiation of mRNA decay. eRF3 also functions in the regulation of apoptosis; eRF3 is cleaved at Ala73 by an as yet unidentified protease into processed isoform of eRF3 (p-eRF3), which interacts with the inhibitors of apoptosis proteins (IAPs). The binding of p-eRF3 with IAPs leads to the release of active caspases from IAPs, which promotes apoptosis. Although full-length eRF3 is localized exclusively in the cytoplasm, p-eRF3 localizes in the nucleus as well as the cytoplasm. We here focused on the role of p-eRF3 in the nucleus. We identified leptomycin-sensitive nuclear export signal (NES) at amino acid residues 61–71 immediately upstream of the cleavage site Ala73. Thus, the proteolytic cleavage of eRF3 into p-eRF3 leads to release an amino-terminal fragment containing NES to allow the relocalization of eRF3 into the nucleus. Consistent with this, p-eRF3 more strongly interacted with the nuclear ARF tumor suppressor than full-length eRF3. These results suggest that while p-eRF3 interacts with IAPs to promote apoptosis in the cytoplasm, p-eRF3 also has some roles in regulating cell death in the nucleus.

  19. A V530I Mutation in c-KIT Exon 10 Is Associated to Imatinib Response in Extraabdominal Aggressive Fibromatosis

    Directory of Open Access Journals (Sweden)

    Jean-Emmanuel Kurtz

    2010-01-01

    Full Text Available Aggressive fibromatosis (AF or desmoid tumor is a rare condition, characterized by deep tissue invasion by a monoclonal fibroblastic neoplasm, developed from musculoaponeurotic structures. Surgery is the treatment of choice, but negative margins can hardly been achieved in large tumors, and can lead to major functional disability. AF medical therapy includes nonsteroids anti-inflammatory drugs, tamoxifen, with inconsistent results. Several reports of imatinib efficacy in AF appear in the literature. Here, we describe for the first time a V530I KIT exon 10 mutant that was associated to a dramatic imatinib response in an extraabdominal aggressive fibromatosis. The previously discovered V530I substitution was characterized in the core binding factor AML, but had never been reported in any other condition, so far. In this paper, we discuss the KIT exon 10 mutations or polymorphisms that have been described in a variety of KIT-related conditions, including acute myelogenous leukemia, mastocytosis, and aggressive fibromatosis.

  20. Low-grade fibromatosis-like spindle cell carcinoma of the breast.

    Science.gov (United States)

    Dwyer, Jessica B; Clark, Beth Z

    2015-04-01

    Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local recurrence, and their favorable prognosis among the metaplastic carcinomas of the breast. The diagnosis is potentially challenging, particularly on core needle biopsies, because of the morphologic overlap with other low-grade spindle cell lesions. Recognition of a proliferation of cytologically bland spindle cells with areas of epithelial differentiation in combination with immunohistochemistry using antibodies against cytokeratins and myoepithelial markers should aid in producing a definitive diagnosis. These tumors can be locally aggressive with an increased incidence of local recurrence, but the potential for lymph node or distant metastasis is low. Complete excision with adequate margins is considered curative in the majority of cases.

  1. Design of Hemispherical Radio Frequency (RF Capacitive-type Electrode Free of Edge Effects for Treatment of Intracavitary Tumors

    Directory of Open Access Journals (Sweden)

    Moriyama,Masahiro

    2012-04-01

    Full Text Available A new hemispherical electrode to heat oral cavity cancer is proposed. The electrode does not produce a hot spot around its edge, a feature that usually arises when using radio frequency (RF capacitive-type heating. The hemispherical electrode was designed by computer simulation using a 3-D finite element method. To assess its practicality and effectiveness, we built a prototype hemispherical electrode and evaluated its heating characteristics by phantom experiments. The heating effects on the phantom were measured by thermography. The concave phantom surface in contact with the hemispherical electrode showed a uniform increase in temperature, with no obvious edge effect. The proposed electrode allows non-invasive RF capacitive-type heating for intracavity tumors that was not previously considered possible, and should contribute to the multidisciplinary treatment of intracavity tumors.

  2. Fibromatosis of the male breast with concurrent florid-type gynecomastia: Report of a case and review of literature.

    Science.gov (United States)

    El Demellawy, Dina; Herath, Chaturika; Khalil, Mazin; Nasr, Ahmed; Moussa, Bassem

    2011-05-15

    Fibromatosis is a soft tissue lesion with infiltrative capacity, and is formed of proliferation of fibroblastic and myofibroblastic cells with a significant risk for local recurrence, but no metastatic potential. Fibromatosis is uncommon in the mammary gland, and accounts for less than 0.2% of all primary breast lesions. To the best of our knowledge, it has not been described in the setting of male breast with concurrent florid-type gynecomastia. We report a rare case of a 45-year-old male presenting with a palpable breast mass that was suspicious of carcinoma clinically. Failure of exclusion of metaplastic carcinoma and other lesions in repeated core biopsies lead to excision, which documented the intra-mammary origin of the lesion and established the diagnosis of fibromatosis. The current case demonstrates that fibromatosis in the male breast may have features and a presentation that can be confused with breast cancer. When obvious breast changes and history do not correlate with routine diagnostic measures, the presence of an unusual breast or chest wall tumor, such as a fibromatosis, should be considered in the differential diagnosis. Crown Copyright © 2010. Published by Elsevier GmbH. All rights reserved.

  3. Magnetic resonance imaging of musculoaponeurotic fibromatosis

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    Hawnaur, J.M.; Jenkins, J.P.R.; Isherwood, I. (Manchester Univ. (UK). Dept. of Diagnostic Radiology)

    1990-10-01

    Musculoaponeurotic fibromatosis can be mistaken for soft-tissue sarcoma both clinically and on X-ray computed tomography. Magnetic resonance imaging (MRI) in three patients with this condition enabled the correct diagnosis to be made prospectively in two. The appearance on MRI of a heterogeneous mass with well-defined, predominantly peripheral areas of very low signal intensity due to dense fibrous tissue and areas of medium to high signal intensity corresponding to a more cellular stroma should raise the suspicion of musculoaponeurotic fibromatosis. Cellular areas within the tumour showed moderate enhancement after gadolinium diethylene triamine pentaacetic acid administration. (orig.).

  4. Aggressive Fibromatosis: Evidence for a Stable Phase

    Directory of Open Access Journals (Sweden)

    Gillian Mitchell

    1998-01-01

    Full Text Available Purpose. Aggressive fibromatosis (AF is an uncommon locally infiltrating benign disease of soft tissue for which treatment comprises complete surgical resection. Radiotherapy can be given postoperatively if the margin is incompletely resected. If the tumour is inoperable radiotherapy provides an alternative treatment. Hormone therapy and cytotoxic chemotherapy have also been used for unresectable or recurrent disease. All treatment modalities carry an associated morbidity. We believe that the natural history of aggressive fibromatosis may include a period of stable disease without progression, during which time, treatment is not always necessary.

  5. Time Trends in the Incidence and Treatment of Extra-Abdominal and Abdominal Aggressive Fibromatosis: A Population-Based Study

    NARCIS (Netherlands)

    D.L.M. van Broekhoven (Danique); D.J. Grunhagen (Dirk Jan); M.A. den Bakker (Michael); T. van Dalen (Thijs); C. Verhoef (Kees)

    2015-01-01

    textabstractBackground: Aggressive fibromatosis (AF) is a locally infiltrating soft-tissue tumor. In a population-based study in the Netherlands, we evaluated time trends for the incidence and treatment of AF. Methods: In PALGA: Dutch Pathology Registry, all patients diagnosed between 1993 and 2013

  6. Differential diagnosis of fibromatosis and fibrosarcoma with histopathologic characteristics and IHC markers

    Directory of Open Access Journals (Sweden)

    Parviz Deyhimi

    2015-01-01

    Methods: In this cross-sectional descriptive analytical study, a total of 40 specimens from pathology department archives in hospitals of Isfahan and Tehran universities from 2003 to 2013, including 20 fibrosarcoma and 20 fibromatosis biopsies, were selected. First, histopathologic characteristics were identified using H&E slides and an optical microscope H&E slides and then they were stained through immunohistochemical staining technique using the EnVision for markers Ki-67 and β-catenin. Afterward the samples were examined by optical microscope and positively stained cells were counted. Results: There was no significant difference between fibromatosis and fibrosarcoma in terms of a mean age (P=0.063, distribution of gender frequency (P=0.197, necrotic rate (P=0.602, clarity of nucleolus (P=0.799 and SID mean of β-catenin marker (0.369. However, it was seen a meaningful difference between fibromatosis and fibrosarcoma in terms of frequency distribution (P=0.017, rate of mitotic figures (P<0.001, rate of herring-bone pattern (P=0.043, rate of cellularity (P<0.001, rate of nucleus overlapping (P<0.001, mean of Ki-67 (P=0.046, mean of Ki-67-limit (P=0.001 and atypia rate (P<0.001. Conclusion: There was a meaningful difference between fibrosarcoma and fibromatosis in terms of mitotic figures, expression of Ki-67 mitotic marker, herring bone pattern, cellularity and atypia. Therefore these features can be used to differentiate the relevant pathological lesions. However, no meaningful difference between two tumors in terms of expression and intensity of β-catenin, clarity of nucleoli and necrosis. This indicates that they are not reliable criteria of differentiation between fibrosarcoma and fibromatosis.

  7. Fibromatosis of thyroid gland (a case report.

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    Samsi A

    1992-01-01

    Full Text Available Fibromatosis of thyroid gland is a rare condition encountered in surgical practice. Clinically presenting as goitre, it is treated with near total thyroidectomy with good results. We had one such case under our care at the K.E.M. Hospital, Bombay. Rarity of this condition prompted us to publish the data, the literature is briefly reviewed.

  8. Mammary Fibromatosis: Sonographic Features and Pathologic Correlations

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Hae Kyoung; Ko, Kyung Hee; Rho, Ji Young; Kang, Hye Yoon [Cha University College of Medicine, Pocheon (Korea, Republic of); Kim, Eun Kyung [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2010-09-15

    The purpose of this study was to determine if the sonographic features of mammary fibromatosis had correlation with the pathologic findings. We identified four cases of fibromatosis of the breast at our institution over a 10-year period. The patients were all women, and they ranged from 25 to 48 years of age (mean, 34.3 years). All four patients complained of palpable breast masses and were subsequently diagnosed with mammary fibromatosis. We retrospectively reviewed their imaging findings. Mammography obtained in one patient revealed architectural distortion. On sonography, all four cases showed spiculated, irregular, hypoechoic masses that could not be differentiated from malignant lesions. After surgical excision and vacuum assisted biopsy of the masses in four patients, there was no recurrence on clinical or sonographic follow-up over a 13-36 month period. Although mammary fibromatosis is a very rare condition, it should be included in the differential diagnosis when an un-calcified, spiculated, irregular and hypoechoic masses are encountered on breast sonography

  9. Lytic clavicular lesions in fibromatosis colli

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    Sartoris, D.J.; Parker, B.R.; Mochizuki, R.M.

    1983-06-01

    Two patients with fibromatosis colli (congenital torticollis) presented with lytic lesions in the clavicle at the insertion of the fibrosed clavicular head of the sternocleidomastoid muscle. Biopsy of one lesion showed intraosseous fibrosis. These lesions are probably not uncommon but radiographs are rarely performed in uncomplicated cases.

  10. Desmoid fibromatosis: MRI features of response to systemic therapy

    Energy Technology Data Exchange (ETDEWEB)

    Sheth, Pooja J.; Subhawong, Ty K. [University of Miami Miller School of Medicine/Jackson Memorial Hospital, Department of Radiology, Miami, FL (United States); Del Moral, Spencer; Wilky, Breelyn A.; Trent, Jonathan C. [University of Miami Miller School of Medicine/Sylvester Comprehensive Cancer Center, Division of Hematology/Oncology, Department of Medicine, Miami, FL (United States); Cohen, Jonathan [Oncology and Radiation Associates, Miami, FL (United States); Rosenberg, Andrew E. [University of Miami Miller School of Medicine, Department of Pathology, Miami, FL (United States); Temple, H.T. [Center for Orthopedic Innovations, Miami, FL (United States)

    2016-10-15

    Imaging criteria for measuring the response of desmoid fibromatosis to systemic therapy are not well established. We evaluated a series of patients with desmoids who underwent systemic therapy to document magnetic resonance imaging (MRI) features associated with a positive clinical response. This Institutional Review Board-approved retrospective study included 23 patients (mean age 40.5) with 29 extra-abdominal tumors. Therapeutic regimens included cytotoxic chemotherapy (n = 19), targeted therapy (n = 3), and nonsteroid anti-inflammatory drugs (NSAIDS; n = 1). Clinical effects were categorized as progressive disease, stable, or partial response. Maximum tumor dimension (D{sub max}), approximate tumor volume (V{sub Tumor}), and quantitative tumor T2 hyperintensity and contrast enhancement (relative to muscle) for pre- and post-treatment MRIs were compared. Three lesions progressed, 5 lesions were stable, whereas 21 showed a clinical response. D{sub max} decreased more in responders (mean -11.0 %) than in stable/progressive lesions (mean -3.6 and 0 % respectively, p = 0.28, ANOVA); by Response Evaluation Criteria in Solid Tumors (RECIST 1.1) 27 out of 29 lesions were ''stable,'' including the 3 progressive lesions. In responders, V{sub Tumor} change averaged -29.4 %, but -19.2 % and +32.5 % in stable and progressive lesions respectively (p = 0.002, ANOVA); by 3D criteria 14 out of 29 lesions showed a partial response. T2 hyperintensity decreased by 50-54 % in partial response/stable disease, but only by 10 % in progressive lesions (p = 0.049, t test). Changes in contrast enhancement ranged from -23 % to 0 %, but were not statistically significant among response groups (p = 0.37). Change in T2 hyperintensity showed a positive correlation with volumetric change (r = 0.40). Decreases in volume and T2 hyperintensity reflect the positive response of desmoid fibromatosis to systemic therapy; RECIST 1.1 criteria are not sensitive to clinically

  11. Slow growing desmoid-type fibromatosis of the breast: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ah Reum; Kim, Ji Young; Kim, Hyun Jung; KIm, Jae Hyung; Jeong, Myeong Ja; Kim, Soung Hee; Kim, Soo Hyun; Kang, Mi Jin; Lee, Ji Hae; Bae, Kyung Eun [Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2017-04-15

    Fibromatosis or desmoid tumor of the breast is a rare benign entity that has no metastatic potential but has significant risk of local recurrence. Its association with previous surgical or accidental trauma and Gardner's syndrome has been reported. Awareness of this lesion is important as the diagnosis is often confused with breast carcinoma. We report a case of a 44-year-old woman who presented with a palpable mass in her left breast, close to the axilla since a few months ago. She had undergone excisional biopsy for her left breast mass 15 months ago, and the diagnosis was confirmed as intraductal papilloma with atypical ductal hyperplasia. Subsequent ultrasound and core needle biopsy revealed stromal fibrosis. After 9 months, the mass showed an increase in its size and the anteroposterior to width ratio on ultrasonography compared to the previous examination, and final excisional biopsy confirmed the diagnosis of desmoid-type fibromatosis.

  12. Inoperable aggressive mesenteric fibromatosis with ureteric fistula

    Energy Technology Data Exchange (ETDEWEB)

    Khanna, Paritosh C. [Radiology Department, Nanavati Hospital, Mumbai (India)]. E-mail: paritoshkhanna@hotmail.com; Lath, Chinar [Radiology Department, Nanavati Hospital, Mumbai (India); Gadewar, Swapna B. [Radiology Department, Nanavati Hospital, Mumbai (India); Agrawal, Dilpesh [Internal Medicine Department, Wockhardt Hospital, Mumbai (India)

    2006-07-15

    The purpose of our report is to illustrate an aggressive case of mesenteric fibromatosis in a 17-year-old girl with a ureteric fistula and to review imaging and pathological features, natural history and treatment options of this disease. Our patient underwent computed tomography that revealed a widespread intra-abdominal mass. The necrotic centre of this mass had a fistulous communication with the right ureter. Fibromatoses represent a spectrum of uncommon benign conditions characterised by proliferating fibrous tissue. The deep intra-abdominal form of mesenteric fibromatosis (MF), one of the rare subtypes of the 'fibromatoses' or 'desmoid tumours', grows rapidly and may become extensive. Surgery provides good results in limited disease and non-surgical modalities in cases of unresectable and residual disease.

  13. Clinicopathological study of three cases of infantile fibromatosis of the orbit.

    Science.gov (United States)

    Hayashi, Kengo; Katori, Nobutada; Otsuki, Yoshiro; Ohno-Matsui, Kyoko

    2014-10-01

    We report the clinical and pathological findings in three infants with infantile fibromatosis that involved several extraocular muscles which led to disorders of ocular motility. We also describe their clinical features before and after surgery. This was a retrospective interventional case study with clinicopathological correlations. We present three cases of infantile fibromatosis that were diagnosed by clinical features and histopathlogical examination of biopsy specimens. The three patients were all female children aged 1, 3, and 3 years at their initial visit. The orbital tumor was unilateral in all patients. All three patients had disorders of ocular motility because the tumors involved ≥2 extraocular muscles. The margins between the tumor and the involved extraocular muscles were not distinct. We performed partial resection of the tumors to preserve the extraocular muscles. In all cases, the tumors partially remained, but periodic postoperative magnetic resonance imaging showed no enlargement of the tumors during the follow-up period. All three patients had residual limitations of eye movements. We should consider the postoperative binocular function when we treat infantile benign fibrous tumors involving the extraocular muscles.

  14. Desmoid Fibromatosis of Submandibular Region

    African Journals Online (AJOL)

    Head and Neck Surgery, Mater Misericordiae University ... and neck. With tumors in this region, patients usually present with trismus ..... Cancer. 2004;100:612‑20. 17. Poon R, Smits R, Li C, Jagmohan‑Changur S, Kong M, Cheon S, et al.

  15. An unusual case of idiopathic gingival fibromatosis

    Directory of Open Access Journals (Sweden)

    Vikender S Yadav

    2013-01-01

    Full Text Available Idiopathic gingival fibromatosisis, a condition of undetermined cause can develop as an isolated disorder, but mostly it is associated with some syndrome. It usually begins at the time of eruption of permanent teeth but can develop with the eruption of deciduous dentition and rarely present at birth. This case report describes an unusual case of non-syndromic generalized idiopathic gingival fibromatosis in a 15-year-old male present since birth. Surgical treatment in the form of ledge and wedge procedure with internal bevel gingivectomy was performed. No recurrence of enlargement was seen after 2 years of follow-up.

  16. Radiotherapy in the management of aggressive fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Atahan, I.L.; Akyol, F.; Zorlu, F.; Guerkaynak, M. (Hacettepe University Hospital, Ankara (Turkey). Dept. of Radiology)

    1989-09-01

    Four case reports are summarised concerning the management of aggressive fibromatosis in children and adolescents up to the age of 15. It was concluded that radiotherapy should be reserved for recurrences or inoperable cases. A dose of 5000-6000 cGy in 25-30 fractions depending on age of patient, site, and size of tumour is necessary, since most surgical recurrences appear in 12 months, all cases with positive surgical margins should receive doses in the range 4000-4500 cGy for microscopic disease. Radiotherapy-chemotherapy combinations can also be used. (UK).

  17. MRI of fibromatosis: with pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, P. (Dept. of Diagnostic Imaging, Hospital for Sick Children, Toronto Univ., ON (Canada)); Thorner, P. (Dept. of Pathology, Hospital for Sick Children, Toronto Univ., OH (Canada))

    1992-12-01

    Fibromatosis refers to group of benign but sometimes locally aggressive proliferative lesions of myofibroblasts. These are characterized by infiltrative growth, and hence may mimic a malignant lesion. These lesions reveal a low signal intensity on T1-weighted pulse sequences, but may show low or high signal intensity on the T2-weighted sequences. Histologic correlation reveals that the lesion showing low signal intensity on T2-weighted sequences has a larger collagenous component, and reduced cellularity compared with the lesion showing high signal intensity on T2-weighted sequences. (orig.)

  18. [Fibromatosis plantaris Ledderhose (Dupuytren's contracture of the foot sole].

    Science.gov (United States)

    Villiger, K J

    1982-05-01

    Fibromatosis plantaris, also called Ledderhose disease, is presented on the basis of the limited literature available. The possible causes are mentioned. Two cases are reported of patients suffering from fibromatosis palmaris (Dupuytren) on both hands and fibromatosis plantaris (Ledderhose) on both feet simultaneously. It is suggested that more attention be paid to examination of the soles of the feet, especially after a period of immobilization and plaster fixation of the shank. On diagnosis of Ledderhose disease, surgery should be performed before the often irreversible deformation of the toes develops.

  19. Mesenteric Fibromatosis: A Rare Cause of Acute Abdominal Pain

    Science.gov (United States)

    Bethune, R; Amin, A

    2006-01-01

    A 45-year-old man, with a previous history of astrocytoma, presented with diffuse abdominal pain. A CT scan was non-specific and the pain worsened; his abdomen became peritonitic on examination. An exploratory laparotomy was performed, and a large small bowel mesenteric mass was found together with an associated haematoma. Subsequent histology showed the tumour to be a benign fibromatosis, and the patient recovered uneventfully. There were no reports in the literature of any association between astrocytomas and fibromatosis. Mesenteric fibromatosis is a rare tumour often associated with Gardner's syndrome. It can present in a multitude of ways and the only definite treatment is surgical resection.

  20. Fallopian Tube Cancer with Palmar Fibromatosis or Fasciitis without Polyarthritis.

    Science.gov (United States)

    Fukui, Shoichi; Fujiwara, Sho; Kobayashi, Satomi; Kamei, Satoshi; Takizawa, Yasunobu; Setoguchi, Keigo; Uno, Masaya; Funata, Nobuaki

    2015-01-01

    A 64-year-old Japanese woman had rapidly progressing bilateral palmar contracture associated with severe pain on both palms over the previous 8 weeks, without a history of arthritis in any joints. We suspected palmar fibromatosis or fasciitis without polyarthritis. Because palmar fibromatosis is known to be associated with cancer, we performed cancer screening and the patient was subsequently diagnosed with fallopian tube cancer. This is the first case report of palmar fibromatosis or fasciitis without polyarthritis associated with fallopian tube cancer. The characteristic rapid progression of palmar contracture is a key finding that suggests the potential existence of a malignancy.

  1. Juvenile fibromatosis of the temporomandibular joint: A rare case report

    Directory of Open Access Journals (Sweden)

    Mohammed Salman Basha

    2014-01-01

    Full Text Available Fibromatosis is the non-malignant proliferation of fibroblasts that aggressively invade adjacent tissues. It is composed of well-differentiated cells separated by considerable collagen and/or reticulin. The cause of this abundant growth is unknown, but many suspect hormonal or traumatic influences. When fibromatosis develops in the temporomandibular joint (TMJ or adjoining tissues, its aggressive growth can compress the trachea and cause death. The management is difficult as it is perplexing to comprehend. Resection is the treatment of choice. The following case report presents a rare case of fibromatosis involving TMJ and its uneventful successful management.

  2. Cholangiocarcinoma accompanied by desmoid-type fibromatosis

    Institute of Scientific and Technical Information of China (English)

    Nan Xu; Zhe-Yu Chen; Lu-NanYan; Jia-YingYang; Wen-TaoWang; Shu-Guang Jing

    2011-01-01

    BACKGROUND: Cholangiocarcinoma complicated by intra-abdominal desmoid-type fibromatosis (DTF) is uncommon. There are no reports on patients with this type of fibromatosis, in which the pre-operative treatment (including diagnosis), surgical approach, post-operative pathologic reports, and prognosis are discussed. METHOD: The clinicopathological features of a 49-year-old man were retrospectively analyzed. RESULTS: Cholangiocarcinoma located in the inferior segment of the bile duct was considered pre-operatively on the basis of clinical findings. At the time of pancreaticoduodenectomy, the mesojejunum was stiff without nodules or a mass at a distance of approximately 80 cm from the ligament of Treitz. Complete excision of the entire lesion of the intestinal mesenteric contracture and its subsidiary was performed. Post-operative pathologic findings confirmed an adenocarcinoma located at the extremity of the common bile duct and infiltrating the full thickness of the common bile duct as well as the deep muscular layer of the duodenum. The contracted jejunal mesentery was shown to have DTF. The patient was alive with no evidence of recurrence after a follow-up of 6 months. CONCLUSIONS: The patient had a rare hereditary disease with intra-abdominal DTF, which manifests the characteristics of an aggressive growth pattern and a high rate of local recurrence;conservative therapy is recommended. Complete excision of the fibromatous lesion during pancreaticoduodenectomy may maximally decrease the risk of local recurrence.

  3. Infantile digital fibromatosis (inclusion body fibromatosis observed in a baby without finger involvement

    Directory of Open Access Journals (Sweden)

    Avni Kaya

    2013-01-01

    Full Text Available A 9-day-old male baby was hospitalized after his birth due to some swells under the skin. The hard consistency nodules observed under the skin all over the body of the patient were of different size, and presented lesions, among which the biggest was 1 × 1 cm. No lesions were observed on the fingers. By superficial ultrasonography, multiple isoechoic hypoechoic lesions were observed among the muscle plan. In thoracolumbar magnetic resonance imaging, multiple massif lesions retaining peripheral contrast (the biggest was 1.7 × 1.4 cm large had been observed under the skin muscle plans, between the muscles of the extremities. The biopsy was positive for smooth muscle actin, but negative for desmin, S100, and CD34. These findings were diagnosed as infantile digital fibromatosis (IDF (inclusion body fibromatosis. The case was presented with an objective to illustrate and remind that IDF can be observed in babies without finger involvement.

  4. Nationwide trends in the current management of desmoid (aggressive) fibromatosis.

    Science.gov (United States)

    Eastley, N C; Hennig, I M; Esler, C P; Ashford, R U

    2015-06-01

    The optimal management of desmoid fibromatosis remains unclear, leading to significant variability in patient management. To assess this problem, the current approach of clinicians managing this complex condition in the UK was investigated. A hypothetical case of intramuscular limb girdle desmoid fibromatosis in a fit 65-year-old patient was devised. Surgical and non-surgical oncology members of the British Sarcoma Group were questioned on how they would manage this case in three scenarios: primary disease with function-sparing surgery possible, primary disease with neurovascular involvement and disease recurrence after a previous R0 resection. Initial management, management of symptomatic disease progression, follow-up preferences and any differences in respondents' management choices in a younger case were investigated. The responses from 14 sarcoma surgeons and 23 oncologists (14 clinical, nine medical) were analysed. Desmoid fibromatosis management is generally shared by surgeons and oncologists within sarcoma multidisciplinary teams in the UK. Variation exists in the chosen initial management of primary desmoid fibromatosis in the UK, with function-sparing surgery possible (observation 51%, resection 51%), primary desmoid fibromatosis with neurovascular involvement (hormone therapy with non-steroidal anti-inflammatory drugs 51%, radiotherapy 27%, observation 22%) and for cases of desmoid fibromatosis recurrence (radiotherapy 41%, hormone therapy and non-steroidal anti-inflammatory drugs 27%, observation 24%). There was a clear preference of surgical resection of symptomatic disease progression in cases of primary desmoid fibromatosis without neurovascular involvement (60%). By contrast, radiotherapy was the preferred treatment for progression in cases with neurovascular involvement (47%) or cases of recurrence after a previous R0 resection (34%). Clinical follow-up was selected 3 months after intervention in 68% of scenarios. Follow-up imaging was selected 3

  5. Ollier's disease in association with adjacent fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Al-Ismail, Khalid; Torreggiani, William C.; Munk, Peter L. [Department of Radiology, Vancouver General Hospital, University of British Columbia, 899 West l2th Avenue, Vancouver, BC (Canada); O' Connell, John X.; Nicolaou, Savvakis [Department of Pathology, Vancouver General Hospital, University of British Columbia, 899 West l2th Avenue, Vancouver, BC (Canada); Masri, Bassam A. [Department of Orthopaedics, Vancouver General Hospital, University of British Columbia, 899 West l2th Avenue, Vancouver, BC (Canada)

    2002-08-01

    Ollier's disease (enchondromatosis) is a nonhereditary disorder of mesodermal dysplasia. It is characterized by the presence of multiple enchondromas that typically affect the metaphyseal ends of bones. The association of Ollier's disease with adjacent fibromatosis has, to our knowledge, not been previously described. We report a case of Ollier's disease in association with soft tissue fibromatosis adjacent to the involved upper arm. (orig.)

  6. Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases☆

    Science.gov (United States)

    Cates, Justin M. M.; Black, Jennifer O.; Itani, Doha M.; Fasig, John H.; Keedy, Vicki L.; Hande, Kenneth R.; Whited, Brent W.; Homlar, Kelly C.; Halpern, Jennifer L.; Holt, Ginger E.; Schwartz, Herbert S.; Coffin, Cheryl M.

    2014-01-01

    Summary Despite reports of receptor tyrosine kinase activation in desmoid-type fibromatosis, therapeutic benefits of kinase inhibitor therapy are unpredictable. Variability in signal transduction or cellular kinases heretofore unevaluated in desmoid tumors may be responsible for these inconsistent responses. In either case, a better understanding of growth regulatory signaling pathways is necessary to assess the theoretical potential of inhibitor therapy. Immunohistochemical analysis of tyrosine kinases and activated isoforms of downstream signal transduction proteins was performed on a tissue microarray containing 27 cases of desmoid-type fibromatosis and 14 samples of scar; 6 whole sections of normal fibrous tissue were studied for comparison. Platelet-derived growth factor receptor, β type, and focal adhesion kinase 1 were expressed in all desmoid tumors and healing scars but only 80% and 50% of nonproliferative fibrous tissue samples, respectively. Hepatocyte growth factor receptor was detected in 89% of desmoids and all scars tested, but not in any of the fibrous tissue samples. Epidermal growth factor receptor was detected in only 12% of desmoids and not in scar or fibrous tissue. Mast/stem cell growth factor receptor, receptor tyrosine–protein kinase erbB-2, and phosphorylated insulin-like growth factor 1 receptor/insulin receptor were negative in all study cases. Variable levels of phosphorylated downstream signal transduction molecules RAC-α/β/γ serine/threonine-protein kinase, mitogenactivated protein kinase, and signal transducer and activator of transcription-3 were observed in desmoids (58%, 62%, and 67%), scar tissues (100%, 86%, and 86%), and fibrous tissue (33%, 17%, and 17%). These results indicate that tyrosine kinase signaling is active in both fibromatosis and healing scar, but not in most nonproliferating fibrous tissues. Although platelet-derived growth factor receptor, β type, is expressed ubiquitously in desmoids, the kinases driving

  7. Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases.

    Science.gov (United States)

    Cates, Justin M M; Black, Jennifer O; Itani, Doha M; Fasig, John H; Keedy, Vicki L; Hande, Kenneth R; Whited, Brent W; Homlar, Kelly C; Halpern, Jennifer L; Holt, Ginger E; Schwartz, Herbert S; Coffin, Cheryl M

    2012-10-01

    Despite reports of receptor tyrosine kinase activation in desmoid-type fibromatosis, therapeutic benefits of kinase inhibitor therapy are unpredictable. Variability in signal transduction or cellular kinases heretofore unevaluated in desmoid tumors may be responsible for these inconsistent responses. In either case, a better understanding of growth regulatory signaling pathways is necessary to assess the theoretical potential of inhibitor therapy. Immunohistochemical analysis of tyrosine kinases and activated isoforms of downstream signal transduction proteins was performed on a tissue microarray containing 27 cases of desmoid-type fibromatosis and 14 samples of scar; 6 whole sections of normal fibrous tissue were studied for comparison. Platelet-derived growth factor receptor, β type, and focal adhesion kinase 1 were expressed in all desmoid tumors and healing scars but only 80% and 50% of nonproliferative fibrous tissue samples, respectively. Hepatocyte growth factor receptor was detected in 89% of desmoids and all scars tested, but not in any of the fibrous tissue samples. Epidermal growth factor receptor was detected in only 12% of desmoids and not in scar or fibrous tissue. Mast/stem cell growth factor receptor, receptor tyrosine-protein kinase erbB-2, and phosphorylated insulin-like growth factor 1 receptor/insulin receptor were negative in all study cases. Variable levels of phosphorylated downstream signal transduction molecules RAC-α/β/γ serine/threonine-protein kinase, mitogen-activated protein kinase, and signal transducer and activator of transcription-3 were observed in desmoids (58%, 62%, and 67%), scar tissues (100%, 86%, and 86%), and fibrous tissue (33%, 17%, and 17%). These results indicate that tyrosine kinase signaling is active in both fibromatosis and healing scar, but not in most nonproliferating fibrous tissues. Although platelet-derived growth factor receptor, β type, is expressed ubiquitously in desmoids, the kinases driving cell

  8. Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour)

    Science.gov (United States)

    Hong, H; Nadesan, P; Poon, R; Alman, B A

    2011-01-01

    Background: Aggressive fibromatosis (desmoid tumour) is a locally invasive tumour caused by mutations resulting in β-catenin protein stabilisation. Apc1638N mice are predisposed to developing aggressive fibromatosis tumours, and male mice develop greater numbers of tumours than female mice, suggesting a role for androgens in this tumour type. Methods: Human aggressive fibromatosis tumours were examined for the expression of the androgen receptor, and primary human tumour cell cultures were treated with testosterone. Orchidectomised Apc1638N mice were investigated for the development of tumours, and were treated with testosterone to study the effect of tumour formation and the level of β-catenin. Results: Androgen receptors are universally expressed in human aggressive fibromatosis tumours. Testosterone increased the proliferation rate and β-catenin protein level in a dose-dependent manner in human aggressive fibromatosis tumours. Orchiectomy reduced the number and size of tumours that formed in male Apc1638N mice to a similar level as observed in female mice. Testosterone treatment increased the number of tumours that formed in orchidectomised male mice, and resulted in a marked increase in β-catenin protein levels. Conclusion: Testosterone regulates β-catenin protein level and proliferation rate in this mesenchymal tumour. This work identifies the therapeutic use of testosterone blockade in aggressive fibromatosis as an area for further investigation. PMID:21468052

  9. Prevalence of palmar fibromatosis with and without contracture in asymptomatic patients.

    Science.gov (United States)

    Diep, Gustave K; Agel, Julie; Adams, Julie E

    2015-01-01

    This retrospective study documents the proportion of hand clinic patients presenting with palmar fibromatosis with and without contracture. All "new" patients >18 years presenting to a single surgeon's hand clinic over a 16-month period were included, and information was abstracted from chart review regarding patient demographics, reason for presentation, presence or absence of palmar fibromatosis, contracture, and prior known diagnosis of Dupuytren's disease. The percentage of asymptomatic patients with palmar fibromatosis was calculated. Of 827 patients, 306 had palmar fibromatosis. Among all patients, 33% of male and 40% of female patients had palmar fibromatosis. Only 8% had contractures, while 92% had palmar fibromatosis without contracture. Among those who had contractures, 81% presented with a primary complaint of Dupuytren's disease (symptomatic contracture). Prevalence of palmar fibromatosis increased with increasing age. The findings demonstrate that Dupuytren's palmar fibromatosis is common and often present without overt contractures.

  10. Time trends in the incidence and treatment of extra-abdominal and abdominal aggressive fibromatosis: a population-based study.

    Science.gov (United States)

    van Broekhoven, Danique L M; Grünhagen, Dirk J; den Bakker, Michael A; van Dalen, Thijs; Verhoef, Cornelis

    2015-09-01

    Aggressive fibromatosis (AF) is a locally infiltrating soft-tissue tumor. In a population-based study in the Netherlands, we evaluated time trends for the incidence and treatment of AF. In PALGA: Dutch Pathology Registry, all patients diagnosed between 1993 and 2013 as having extra-abdominal or abdominal wall aggressive fibromatosis were identified and available pathology data of the patients were evaluated. Epidemiological and treatment-related factors were analyzed with χ (2)and regression analysis. During the study period, 1134 patients were identified. The incidence increased from 2.10 to 5.36 per million people per year. Median age at the time of diagnosis increased annually by B 0.285 (P = 0.001). Female gender prevailed and increased over time [annual odds ratio (OR) 1.022; P = 0.058]. All anatomic localizations, but in particular truncal tumors, became more frequent. During the study period diagnostic histological biopsies were performed more often (annual OR 1.096; P fibromatosis was observed. The workup of patients improved and a trend towards a nonsurgical treatment policy was observed.

  11. A case of desmoid-type fibromatosis arising after thoracotomy for lung cancer with a review of the english and Japanese literature.

    Science.gov (United States)

    Mori, Takeshi; Yamada, Tatsuya; Ohba, Yasuomi; Yoshimoto, Kentaro; Ikeda, Koei; Shiraishi, Kenji; Suzuki, Makoto

    2014-01-01

    Chest wall desmoid-type fibromatoses are rare, locally aggressive tumors that occasionally arise from previous thoracotomy sites. Tumors arising from previous sites of thoracotomy to treat malignant disease should be discriminated from the pleural dissemination of the previous malignancy. In this study, we report a case of desmoid-type fibromatosis arising from a site for thoracotomy to treat lung cancer. Additionally we reviewed 15 reported cases of desmoid-type fibromatosis following thoracotomy and summarized their features. A 62-year-old woman was found to have a tumor on computed tomography (CT) at a 1-year routine checkup for lung cancer. The tumor (diameter, 3.4 cm) was located at the previous thoracotomy site. Positron emission tomography (PET) revealed mild (18)F-fluorodeoxyglucose (FDG) accumulation in the tumor, with a maximal standardized uptake value (SUVmax) of 1.9. CT-guided biopsy revealed only fibrous tissue. Eighteen months after the biopsy, CT revealed apparent tumor growth, and a biopsy revealed the same histology observed previously. The tumor was removed and diagnosed as desmoid-type fibromatosis. Currently, the patient is alive without recurrence 4 years after desmoid surgery.

  12. Familial gingival fibromatosis: A rare case report

    Directory of Open Access Journals (Sweden)

    Shweta Sharma

    2012-01-01

    Full Text Available Hereditary gingival fibromatosis is a rare condition that can occur as an isolated disease or as part of a syndrome or chromosomal abnormality. In severe cases, the gingival enlargement may cover the crowns of teeth and cause severe functional and aesthetic concerns. Here, we present a case of an 8-year-old girl with severe enlargement of gums in maxilla and mandible. Both deciduous and permanent teeth were not erupted in the oral cavity at all. Mutation in the Son-of-Sevenless (SOS-1 gene has been associated with the disease. The diagnosis was made based on clinical examination and family history. Surgical removal of the hyperplastic tissue was performed under general anesthesia.

  13. A case of juvenile hyaline fibromatosis.

    Science.gov (United States)

    Yayli, Savaş; Uncu, Sibel; Alpay, Köksal; Yildiz, Kadriye; Cimşit, Gülseren; Bahadir, Sevgi

    2006-04-01

    Juvenile hyaline fibromatosis (JHF) is a rare, autosomally-recessive disease characterized by papulonodular skin lesions, soft tissue masses, joint contractures, gingival hypertrophy and osteolytic bone lesions. Its onset is in infancy or early childhood. The most commonly affected sites are the nose, chin, ears, scalp, back and knees. The accumulation of an amorphous, hyaline material is typical in the skin and the other organs. Herein, we report a 14-month-old boy who presented with confluent pink papules on the paranasal folds and the chin, and nodular lesions on the periauricular and perianal regions. He had gingival hypertrophy and contractures of the shoulders, knees and elbows. He also had third-degree consanguineous parents. Histopathological studies confirmed the diagnosis of JHF with the presence of increased numbers of fibroblasts embedded in a hyalinized connective tissue stroma.

  14. Role of technetium-99m pertechnetate scintigraphy in the management of extra-abdominal fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Terui, Shoji [Div. of Nuclear Medicine, National Cancer Hospital, Tokyo (Japan); Terauchi, Takashi [Div. of Nuclear Medicine, National Cancer Hospital, Tokyo (Japan); Abe, Hiroyuki [Div. of Nuclear Medicine, National Cancer Hospital, Tokyo (Japan); Muramatsu, Yukio [Div. of Diagnostic Radiology, National Cancer Hospital, Tokyo (Japan); Fukuma, Hisatoshi [Div. of Orthopedics, National Cancer Center Hospital, Tokyo (Japan); Beppu, Yasuo [Div. of Orthopedics, National Cancer Center Hospital, Tokyo (Japan); Yokoyama, Ryohei [Div. of Orthopedics, National Cancer Center Hospital, Tokyo (Japan)

    1995-07-01

    The purpose of this study was to investigate technetium-99m pertechnetate (Tc-99m) as a tumorscanning agent in patients with extra-abdominal fibromatosis, and to establish the sensitivity of this type of scintigraphy. Eleven patients with extra-abdominal fibromatosis were studied: all but one having postsurgical recurrences. Of the 11 patients, diagnosed histologically, 5 underwent repeated Tc-99m scintigraphic follow-up examinations. The injected 370 MBq Tc-99m gave us an early scintigram within 10 min and a delayed one 2 h later. For adequate comparison, the region of interest (ROI) of the scintigram was placed over the tumor. The tumor-to-background (T/BG) count ratio was computed. Extra-abdominal fibromatoses, even recurrences, were demonstrated scintigraphically in both the early and the delayed phase, in all 11 patients. The average T/BG ratio was 2.11 in the early scintigram and 2.15 in the delayed one. The sensitivity and the specificity were both 100%. Tc-99m scintigraphy has proved useful in detecting extra-abdominal fibromatoses and in the follow-up of patients. (orig.)

  15. Congenital infantile digital fibromatosis: a case report and review of the literature

    Science.gov (United States)

    Failla, Valérie; Wauters, Odile; Nikkels-Tassoudji, Nazli; Carlier, Alain; André, Josette; Nikkels, Arjen F

    2009-01-01

    Infantile digital fibromatosis (IDF) is a rare benign fibroproliferative tumor of early childhood. IDF preferentially affects the fingers and the toes. Malignant transformation or metastases have never been reported. Surgical treatment has been advocated previously but local recurrences were observed frequently. Recent literature supports clinical surveillance without any medical or surgical intervention as spontaneous regression usually occurs after two to three years. A six-month-old Caucasian girl with IDF on the left fourth digit is presented here. The tumor progressively increased in size after birth. Topical imiquimod cream and diflucortolone valerate cream, both displaying antifibrotic properties, had no effect on tumor growth. Currently the lesion size remains stable without any treatment. Early recognition of IDF is important in order to avoid unnecessary surgical intervention that may prove to be potentially aggravating, unless serious functional or cosmetic concerns intervene. Parents should be reassured concerning the benign nature of IDF and be informed that spontaneous involution of IDF might be expected. PMID:21139926

  16. Aggressive intracranial fibromatosis: case report Fibromatose agressiva intracraniana: relato de caso

    Directory of Open Access Journals (Sweden)

    Oswaldo Inácio de Tella Jr

    2006-06-01

    Full Text Available Fibromatosis is a locally aggressive, proliferative fibroblastic lesion affecting musculoaponeurotic structures, most often in the limbs and trunk. Intracranial fibromatosis is extremely rare and requires aggressive treatment to prevent recurrence. Case Description - We present the case of a 20 year old woman with aggressive skull base fibromatosis. The lesion extended through the sphenoid, ethmoid sinus and nasal cavity, destroying the right roof of the orbit and penetrating in anterior skull base. A combined anterior craniofacial approach was performed; complete resection with surgical margin was impossible due to the localization of the tumor and relation to important neurovascular structures. Complete resection with surgical margin is often impossible because of its widely infiltrative nature. Radiotherapy and chemotherapy are often required to improve local control of the lesion.Fibromatose é lesão fibroblástica proliferativa com agressividade localizada, afetando as estruturas músculo-aponeuróticas e acometendo, mais freqüentemente, os membros e tronco. A fibromatose intracraniana é rara e requer tratamento agressivo para evitar recidiva. Descrevemos uma paciente de 20 anos portadora de fibromatose agressiva de base de crânio. A lesão se estendia através da cavidade nasal, seios esfenoidal e etmoidal, destruindo o teto da órbita direita e invadindo a porção anterior da base do crânio. A paciente foi submetida a uma via craniofacial anterior combinada, não sendo possível uma ressecção completa devido ao envolvimento de estruturas neurovasculares. A ressecção completa é, freqüentemente, impossível devido sua natureza infiltrativa. Radioterapia e quimioterapia são indicadas para melhorar o controle da lesão.

  17. Current concepts on gingival fibromatosis-related syndromes.

    Science.gov (United States)

    Poulopoulos, Athanasios; Kittas, Dimitrios; Sarigelou, Asimina

    2011-08-01

    Gingival fibromatosis is a rare, benign, slowly-growing fibrous overgrowth of the gingiva, with great genetic and clinical heterogeneity. Gingival fibromatosis/overgrowth can be inherited as an isolated trait (hereditary gingival fibromatosis) and/or as a component of a syndrome, or it can be drug induced. As a clinical manifestation of a syndrome, gingival fibromatosis is usually associated with generalized hypertrichosis, mental retardation, or epilepsy. Gingival fibromatosis and its related syndromes are mainly inherited in an autosomal-dominant manner, but autosomal-recessive inheritance has also been reported. Clinical syndromic presentation includes Zimmermann-Laband syndrome, Ramon syndrome, Rutherford syndrome, Cowden syndrome, Cross syndrome, Göhlich-Ratmann syndrome, Avani syndrome, and I-cell disease. However, a phenotypic overlap has been suggested, as many combinations of their systemic manifestations have been reported. Treatment of choice is usually gingivectomy with gingivoplasty. Before any therapy, clinical practitioners must take into consideration the clinical course of a particular syndrome and every possible functional and esthetic disorder.

  18. Palmar-plantar fibromatosis in children and preadolescents: a clinicopathologic study of 56 cases with newly recognized demographics and extended follow-up information.

    Science.gov (United States)

    Fetsch, John F; Laskin, William B; Miettinen, Markku

    2005-08-01

    Palmar-plantar fibromatosis, the most common type of fibromatosis, is well recognized in the adult population, but many clinicians and pathologists are unfamiliar with the fact that children may also be affected by this process. This report describes the clinicopathologic findings in 56 cases of palmar-plantar fibromatosis in children and preadolescents. Our study group included 19 males and 37 females, ranging from 2 to 12 years of age at the time of their first surgical procedure (median age, 9 years). The patients typically presented with solitary, lobular or multilobular masses in the 0.5- to 2.5-cm size range. The preoperative duration of the lesions ranged from 1 month to 6 years, with 1 patient purportedly having clinical evidence of disease since birth. All but two of the initial lesions occurred on the plantar aspect of the feet, typically in the region of the arch. Only 2 patients presented with palmar disease. The tumors were usually painless, except when pressure was applied. Seven patients had a history of trauma, sometimes involving a foreign body. One patient presented with concurrent disease involving both feet, and 12 additional patients subsequently developed palmar-plantar fibromatosis in another extremity, knuckle pads on the hands, or had other clinical findings linked to this disease. A family history was available for 25 patients, and 11 individuals had relatives with palmar-plantar fibromatosis, and 4 others had relatives with a history that was either suspicious for palmar-plantar disease or positive for other disorders associated with this disease. Histologically, the tumors involved aponeurosis and commonly formed discontinuous, moderately cellular, nodular masses composed of spindled cells with intervening collagen. Mitotic counts for 79 separately submitted tumor specimens ranged from 0 to 31 mitotic figures per 25 wide-field high power fields (mean mitotic count, 3.4 mitotic figures per 25 wide-field high power fields). Eight tumor had

  19. CTNNB1 Mutations and Estrogen Receptor Expression in Neuromuscular Choristoma and Its Associated Fibromatosis.

    Science.gov (United States)

    Carter, Jodi M; Howe, Benjamin M; Hawse, John R; Giannini, Caterina; Spinner, Robert J; Fritchie, Karen J

    2016-10-01

    Neuromuscular choristoma (NMC) is a very rare, developmental malformation characterized by the endoneurial intercalation of mature muscle fibers among peripheral nerve fibers. NMC typically arises in the major proximal peripheral nerves, most commonly the sciatic nerve, and may involve the lumbosacral and brachial plexus. Patients present clinically with progressive neuropathy or plexopathy. NMC is strongly associated with development of a fibromatosis, histologically identical to conventional desmoid-type fibromatosis (NMC-fibromatosis). The development of NMC-fibromatosis is often precipitated by iatrogenic trauma (ie, biopsy). Desmoid-type fibromatosis is characterized by CTNNB1 exon 3 mutations, which result in aberrant nuclear β-catenin localization and dysregulated canonical Wnt signaling. In contrast, the pathogenesis of NMC and NMC-fibromatosis is unknown. Desmoid-type fibromatosis expresses estrogen receptors (ER), specifically the ER-beta isoform (ERβ), and endocrine therapies may be used in surgically unresectable cases. In contrast, the ER expression profile of NMC-fibromatosis is unknown. We evaluated a series of NMC and NMC-fibromatosis for CTNNB1 mutations, β-catenin expression, and ER isoform expression. Five NMCs occurred in 2 female and 3 male patients (median age: 14 y, range T (p.S45F) and 1 c.121 A>G (p.T41A). Four patients subsequently developed NMC-fibromatosis, and all 4 cases contained CTNNB1 mutations, including 1 p.T41A and 3 p.S45F mutations. In 3 patients, the NMC and NMC-fibromatosis had identical CTNNB1 mutations. Only 1 NMC had no detectable CTNNB1 mutation; however, the patient's subsequent NMC-fibromatosis had a CTNNB1 p.T41A mutation. All NMC and NMC-fibromatosis showed aberrant nuclear localization of β-catenin, nuclear ERβ expression, and no ERα expression. The presence of CTNNB1 mutations both in NMC and NMC-fibromatosis may be a shared molecular genetic abnormality underlying their pathogenesis.

  20. Limb salvage surgery in the excision of a massive fibromatosis.

    Science.gov (United States)

    Redmond, Karen C; Kuppusamy, Madhankumar; Nicholson, Andrew G; Searle, Adam; Thomas, Meirion; Goldstraw, Peter

    2011-09-01

    Fibromatosis is a rare fibroproliferative disorder with a tendency for local infiltrative and destructive growth. Local recurrence is frequent, despite apparent complete resection after radical excision. We present a case of a 22-year-old woman with massive recurrent thoracic fibromatosis extending into the neck and impairing the function of her right upper limb. This required a multidisciplinary approach to surgery to salvage the limb. The case highlights the fact that while every attempt should be made to achieve negative histologic margins, local recurrence is not uncommon. Therefore, if fibromatosis occurs adjacent to or involves vital structures, these should not be sacrificed to achieve negative margins. Function and structure preserving procedures are important as the primary goal, if not even more important. Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  1. Fibromatosis over the dorsa of both feet: An unusual presentation

    Science.gov (United States)

    Kishan Kumar, Y. Hari; Sujatha, C.; Jayaprasad, Sushmitha

    2015-01-01

    Fibromatosis is benign fibrous tissue condition intermediate between benign fibroma and metastasizing fibrosarcoma. The lesion tends to infiltrate and recur when removed, but do not metastasize. The lesion may be single or multiple, and the likelihood of recurrence after surgical removal varies with location of the lesion and age. A 40-year-old female presented with multiple raised lesions over both feet since 4 years, they were multiple well-defined firm nodules coalescing to form lobulated plaques distributed in a symmetrical pattern over the dorsum of both feet. Histopathology of skin showed epidermis with hyperkeratosis, acanthosis, mild parakeratosis, and prominent granular layer. Superficial dermis was unremarkable and deep dermis showed thick bundles of irregular collagen and fibroblastic proliferation, suggestive of fibromatosis. This case is being reported for its unusual presentation of fibromatosis over the dorsum of both feet. PMID:25821730

  2. The diagnosis of mesenteric fibromatosis: A 90-month five patients case report.

    Science.gov (United States)

    Li, Peixin; Zhang, Zhongtao; Qin, Shengqi; Li, Jianshe

    2016-01-01

    Mesenteric fibromatosis (MF) is a rare tumor (2-4 cases per 1 million people annually) with few presented features. In this case study, we reported five MF patients, one of whom suffered a recurrence. Patients received renogram, colonoscopy, cystoscopy, and gastrointestinal examinations. Histology and immunohistochemistry evaluations were performed after the surgical resection. Hormone levels were measured before and after the surgery. It was found that clinical imaging readily confirmed an abnormal mass but was unable to distinguish MF from other tumors. Histology and immunohistochemistry were definitive diagnoses because the tissue was vimentin ± β-catenin ± CD117-/CD34-. Furthermore, the patient who suffered a recurrence showed an elevated estrogen level. A 6-month postoperative administration of letrozole drove the estrogen down to normal level. Our study showed that vimentin, β-catenin, CD117, and CD34 were the markers for MF whereas medical imaging, and estrogen level could be used for the complimentary purpose.

  3. Plantar fibromatosis may adopt the brain gyriform pattern of a low-grade fibromyxoid sarcoma.

    Science.gov (United States)

    Touraine, Sébastien; Bousson, Valérie; Kaci, Rachid; Parlier-Cuau, Caroline; Haddad, Samuel; Laouisset, Liess; Petrover, David; Laredo, Jean-Denis

    2013-01-01

    We report the case of a 42-year-old man with histologically proven plantar fibromatosis (Ledderhose disease) demonstrating an uncommon brain gyriform pattern at MRI, so far exclusively described in the low-grade fibromyxoid sarcoma (LGFMS). An acoustic posterior enhancement at ultrasound, a high intensity on T2w and post-contrast T1wMR images were unusual and related to a high tumor cellularity at histology with no myxoid tissue. The juxtaposition of areas of high and low cellularity (with more fibrous material) in a multilobulated mass built a brain gyriform pattern at MR, similar to what was so far described exclusively in LGFMS. This case demonstrates that the brain gyriform pattern may also be observed in other soft tissue fibrous tumors with no myxoid material but with high cellularity areas alternating with fibrous zones of low cellularity. Copyright © 2012 Elsevier Ltd. All rights reserved.

  4. Desmoid Fibromatosis of the Abdominal Wall: Surgical Resection and Reconstruction with Biological Matrix Egis®

    Directory of Open Access Journals (Sweden)

    Saveria Tropea

    2017-02-01

    Full Text Available Desmoid tumor is a rare monoclonal fibroblast proliferation that is regarded as benign. The clinical management of desmoid tumors is very complex and requires a multidisciplinary approach because of the unpredictable disease course. For those cases localized in the anterior abdominal wall, symptomatic and unresponsive to medical treatment, radical resection and reconstruction with a prosthetic device are indicated. We present here a case of desmoid fibromatosis of the left anterolateral abdominal wall with a marked increase of the mass that required a large excision followed by reconstruction with biological matrix. The fact that it can be incorporated in patient tissue without a fibrotic response and that it can resist future infections, together with a very competetive price, made the new collagen matrix Egis® our first choice.

  5. Fibromatosis mamaria, diagnóstico diferencial del carcinoma invasor: Reporte de un caso

    OpenAIRE

    DÍAZ C,M. LORENA  ; ARANCIBIA H,PATRICIA; Moyano S,Leonor; Burgos S,Nelson

    2009-01-01

    Introducción: La fibromatosis o tumor desmoide, es una lesión infrecuente del tejido conectivo, que corresponde al 0,2% de los tumores mamarios. No tiene potencial de dar metástasis pero presenta alta tasa de recidiva local debido a sus márgenes infiltrativos. Su etiología es desconocida. La presentación clínica e imagenológica es casi indistinguible a la de un carcinoma mamario. El diagnóstico es histológico y el tratamiento de elección es la resección quirúrgica. Reporte de caso: Mujer de 3...

  6. Keratinocytes modify fibroblast metabolism in hereditary gingival fibromatosis.

    NARCIS (Netherlands)

    Meng, L.; Ye, X.; Fan, M.; Xiong, X.; Hoff, J.W. Von den; Bian, Z.

    2008-01-01

    OBJECTIVES: Hereditary gingival fibromatosis (HGF) is a rare benign disorder characterized by progressive fibrous overgrowth of the gingiva. The proliferation and expression of growth factors of HGF keratinocytes are abnormal. However, the exact role of keratinocytes in HGF pathogenesis is still unk

  7. Pazopanib, a promising option for the treatment of aggressive fibromatosis

    NARCIS (Netherlands)

    Szucs, Z.; Messiou, C.; Wong, H.H.; Hatcher, H.; Miah, A.; Zaidi, S.; Graaf, W.T.A. van der; Judson, I.; Jones, R.L.; Benson, C.

    2017-01-01

    Desmoid tumour/aggressive fibromatosis (DT/AF) is a rare soft-tissue neoplasm that is locally aggressive but does not metastasize. There is no standard systemic treatment for symptomatic patients, although a number of agents are used. Tyrosine kinase inhibitors have recently been reported to show us

  8. Can the MRI signal of aggressive fibromatosis be used to predict its behavior?

    Energy Technology Data Exchange (ETDEWEB)

    Castellazzi, G. [Department of Radiology, Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milano (Italy); Department of Radiology, Institut de Cancerologie Gustave Roussy, Villejuif (France); Vanel, D. [Istituti Ortopedici Rizzoli, 1/10 via di Barbiano, Bologna (Italy); Department of Radiology, Institut de Cancerologie Gustave Roussy, Villejuif (France)], E-mail: dvanel@ior.it; Le Cesne, A. [Department of Medicine, Institut de Cancerologie Gustave-Roussy, Villejuif (France); Le Pechoux, C. [Department of Radiotherapy, Institut de Cancerologie Gustave-Roussy, Villejuif (France); Caillet, H. [Department of Radiology, Institut de Cancerologie Gustave Roussy, Villejuif (France); Perona, F. [Department of Radiology, Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milano (Italy); Bonvalot, S. [Department of Surgery, Institut de Cancerologie Gustave-Roussy, Villejuif (France)

    2009-02-15

    Purpose: Aggressive fibromatosis is an invasive non-metastasizing soft-tissue tumor. Until recently, the standard treatment combined surgery and radiation therapy, but new studies reported that conservative strategies with or without medical treatment could be the best management. The aim of this study was to analyze and correlate the size and MR imaging signal features of aggressive fibromatosis with its behavior in order to choose the best treatment. Materials and methods: Between March 1985 and December 2005, 27 patients with at least 2 consecutive MRI examinations and no surgery or radiation therapy in between were recorded. There were 9 men and 18 women, and median age was 31 years. They underwent 107 MRI examinations of 47 lesions, 29 of which were medically treated, while the remaining 18 did not receive any drug administration. The size and signal changes of each lesion were studied over time on T2- and/or T1-weighted sequences after injection of contrast medium. RECIST criteria were used for size: only a 30% decrease or a 20% increase in the size of the main dimension was considered significant. We classified the appearance of the signal into six categories in order of increasing intensity and then we established the related variations over time. Results: The size of 79% of the lesions in the treated group and 82% in the untreated group remained stable. The initial signal of stable lesions or those exhibiting an increase in size was most frequently high. There was a high rate of signal stability over time, whatever the initial signal and size changes. Changes in size were not correlated with the initial MR signal. A decrease in size associated with a decreased signal was observed in three cases exclusively in the treated group. Conclusion: Fibromatoses are a group of soft-tissue tumors with variable characteristics on MRI, but it is not possible to predict their behavior based on the MRI signal.

  9. The Autosomal Recessive Inheritance of Hereditary Gingival Fibromatosis

    Directory of Open Access Journals (Sweden)

    Poulami Majumder

    2013-01-01

    Full Text Available Hereditary gingival fibromatosis (HGF is a rare condition which is marked by enlargement of gingival tissue that covers teeth to various extents leading to aesthetic disfigurement. This study presents a case of a 28-year-old female patient and 18-year-old male who belong to the same family suffering from HGF with chief complaint of overgrowing swelling gingiva. The presence of enlarged gingiva with the same eruption was found in their other family members with no concomitant drug or medical history, and the occurrence of HGF has been found in one generation of this family which may indicate the autosomal recessive inheritance pattern of HGF. Hereditary gingival fibromatosis is an idiopathic condition as its etiology is unknown and it was found to recur in some cases even after surgical treatment. Both patients underwent thorough oral prophylaxis and later surgical therapy to correct the deformity.

  10. Continuous phenobarbital treatment leads to recurrent plantar fibromatosis.

    Science.gov (United States)

    Strzelczyk, Adam; Vogt, Heinrich; Hamer, Hajo M; Krämer, Günter

    2008-11-01

    Despite contrary recommendations by expert opinion and international guidelines phenobarbital remains the most widely prescribed anticonvulsant worldwide. Although associated connective tissue disorders were described in a timely way after its introduction, the association between plantar fibromatosis--also called Ledderhose syndrome--and phenobarbital seems not to be well known in general. Our case series uniquely demonstrates that continuous phenobarbital treatment leads to recurrent plantar fibromatosis and may result in long-term disability and numerous unnecessary operations. In general, the association between connective tissue disorders and phenobarbital most prominently appears in adult patients of northern European descent. However, our case series and data from the literature suggest that patient groups less susceptible to connective tissue disorders may as well develop Ledderhose syndrome or other associated syndromes as Dupuytren's contractures, frozen shoulder, Peyronie's disease or complex regional pain syndrome in the course of phenobarbital treatment.

  11. Hereditary Nonsyndromic Gingival Fibromatosis: Report of Family Case Series

    Directory of Open Access Journals (Sweden)

    Syed Wali Peeran

    2013-01-01

    Full Text Available Hereditary gingival fibromatosis (HGF is a rare, benign disorder with slowly progressive enlargement of maxillary and mandibular gingiva. Herewith, we report the first case series of HGF presenting among mother and all of her 3 children. Their complaints included unaesthetic appearance due to gingival growth, malocclusion, and difficulty in mastication. Conventional gingivectomy with oral hygiene measures and regular followup is the treatment of choice for such presentation.

  12. Non syndromic gingival fibromatosis in a mild mental retardation child

    Directory of Open Access Journals (Sweden)

    Mahesh K Duddu

    2012-01-01

    Full Text Available Gingival fibromatosis is a benign oral condition characterized by enlargement of gingival tissues. It usually develops as an isolated disorder but can be one of the features of a syndrome. This case report is of a 5-year-old male with severe gingival hyperplasia and mild mental retardation which was complicated by open bite, abnormal occlusion, open lip posture, and disabilities associated with mastication and speech. Full mouth gingivectomy in single sitting under general anesthesia was done with electrocautery.

  13. [Unilateral idiopathic gingival fibromatosis--a case report].

    Science.gov (United States)

    Łazarz-Bartyzel, Katarzyna; Gawron, Katarzyna; Darczuk, Dagmara; Chomyszyn-Gajewska, Maria

    2016-01-01

    Gingival fibromatosis is a painless gingival overgrowth. It may result in difficulties with proper dental hygiene keeping, mastication and occlusion. Herein, a case of a 10-year-old patient was described. The patient reported to the Department of Periodontology and Oral Medicine of the Jagiellonian University Medical College in Krakow due to the problems with permanent teeth eruption (23-26), chewing and dental hygiene maintaining. Based on medical history, clinical examination, diagnostic tests and histopathological study of gingival tissue biopsies the patient was diagnosed with unilateral idiopathic gingival fibromatosis. After oral cavity hygienization, patient un- derwent dental surgery procedures by gingivectomy and gingivoplasty. The follow-up examination 2 and 6 months post operation showed un- eventful healing, proper tooth eruption, improved oral hygiene and chewing function. Twelve months post surgery no recurrence was noted. Due to the etiological diversity of gingival lesions occurring as an overgrowth, accurate medical history, clinical examination, laboratory tests and histopathological study are needed. Accurate diagnos- tics is crucial mainly to exclude he- matological and oncological diseases. Gingivectomy being the "gold method" of gingival fibromatosis treatment was effective and sufficient to cure the case presented in this article.

  14. Hyaline fibromatosis of Hoffa's fat pad in a patient with a mild type of hyaline fibromatosis syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Raak, Sjoerd M. van [Albert Schweitzer Hospital, Department of Radiology, Dordrecht (Netherlands); Meuffels, Duncan E. [Erasmus MC - University Medical Center, Department of Orthopaedic Surgery, Rotterdam (Netherlands); Leenders, Geert J.L.H. van [Erasmus MC - University Medical Center, Department of Pathology, Rotterdam (Netherlands); Oei, Edwin H.G. [Erasmus MC - University Medical Center, Department of Radiology, Rotterdam (Netherlands)

    2014-04-15

    Hyaline fibromatosis syndrome (HFS) is a rare, homozygous, autosomal recessive disease, characterized by deposition of hyaline material in skin and other organs, resulting in esthetic problems, disability, and potential life-threatening complications. Most patients become clinically apparent in the first few years of life, and the disorder typically progresses with the appearance of new lesions. We describe a rare case of a 20-year-old patient with juvenile-onset mild HFS who presented with a history of progressive anterior knee pain. Detailed magnetic resonance (MR) imaging findings with histopathological correlation are presented of hyaline fibromatosis of Hoffa's fat pad, including differential diagnosis. The diagnosis of HFS is generally made on basis of clinical and histopathological findings. Imaging findings, however, may contribute to the correct diagnosis in patients who present with a less typical clinical course of HFS. (orig.)

  15. Congenital infantile digital fibromatosis: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Nazli Nikkels-Tassoudji

    2009-12-01

    Full Text Available Infantile digital fibromatosis (IDF is a rare benign fibroproliferative tumor of early childhood. IDF preferentially affects the fingers and the toes. Malignant transformation or metastases have never been reported. Surgical treatment has been advocated previously but local recurrences were observed frequently. Recent literature supports clinical surveillance without any medical or surgical intervention as spontaneous regression usually occurs after two to three years. A six-month-old Caucasian girl with IDF on the left fourth digit is presented here. The tumor progressively increased in size after birth. Topical imiquimod cream and diflucortolone valerate cream, both displaying antifibrotic properties, had no effect on tumor growth. Currently the lesion size remains stable without any treatment. Early recognition of IDF is important in order to avoid unnecessary surgical intervention that may prove to be potentially aggravating, unless serious functional or cosmetic concerns intervene. Parents should be reassured concerning the benign nature of IDF and be informed that spontaneous involution of IDF might be expected.

  16. Idiopathic gingival fibromatosis with asymmetrical presentation and electrosurgical management.

    Science.gov (United States)

    Pol, Dilip Ganpat; Lobo, Tanya Marguerite; Pol, Samruddhi Dilip

    2016-01-01

    Idiopathic gingival fibromatosis is a rare genetically heterogeneous condition characterized by recurrent gingival enlargement without any identifiable cause. We report a case of 14-year-old female patient affected with sporadic, nonsyndromic, progressive gingival enlargement. It manifested more severely on the right side of the mouth with history of recurrence after prior conventional surgical excision. Electrosurgical resection of the enlargement was done, and overall patient management had a successful outcome along with achieving preservation of teeth with poor prognosis in the 2 years follow-up.

  17. Idiopathic gingival fibromatosis with asymmetrical presentation and electrosurgical management

    Directory of Open Access Journals (Sweden)

    Dilip Ganpat Pol

    2016-01-01

    Full Text Available Idiopathic gingival fibromatosis is a rare genetically heterogeneous condition characterized by recurrent gingival enlargement without any identifiable cause. We report a case of 14-year-old female patient affected with sporadic, nonsyndromic, progressive gingival enlargement. It manifested more severely on the right side of the mouth with history of recurrence after prior conventional surgical excision. Electrosurgical resection of the enlargement was done, and overall patient management had a successful outcome along with achieving preservation of teeth with poor prognosis in the 2 years follow-up.

  18. Hereditary gingival fibromatosis with distinct dental, skeletal and developmental abnormalities.

    Science.gov (United States)

    Katz, Joseph; Guelmann, Marcio; Barak, Shlomo

    2002-01-01

    A case of a 9-year-old child with hereditary gingival fibromatosis, supernumerary tooth, chest deformities, auricular cartilage deformation, joint laxity and undescended testes is described. The exact mode of inheritance is unclear; a new mutation pattern is possible. These features resemble but differ from the previously reported Laband syndrome. The dental treatment consisted of surgical removal of the fibrous tissue and conservative restorative treatment under general anesthesia. The dental practitioner should be alert for developmental abnormalities such as supernumerary teeth and delayed tooth eruption. A comprehensive medical history and physical systemic evaluation is essential to rule out other systemic abnormalities. Genetic consultation is mandatory for future family planing.

  19. A rare case of isolated idiopathic gingival fibromatosis

    Directory of Open Access Journals (Sweden)

    Ashish Saini

    2013-01-01

    Full Text Available Idiopathic gingival fibromatosis (IGF is a rare condition. It is genetically heterogeneous and is usually part of a syndrome or, rarely, an isolated disorder. This study presents a rare case of 13 year old boy who was diagnosed with isolated IGF. This diagnosis has been based on clinical examination and after ruling out family, drug, and medical histories. External bevel gingivectomy has been done to remove excess gingival tissues. Excised tissue has been examined histologically. The patient has been followed up for a period of two and half years. No recurrence has been observed.

  20. A rare case of isolated idiopathic gingival fibromatosis.

    Science.gov (United States)

    Saini, Ashish; Singh, Meghna; Singh, Saimbi C

    2013-01-01

    Idiopathic gingival fibromatosis (IGF) is a rare condition. It is genetically heterogeneous and is usually part of a syndrome or, rarely, an isolated disorder. This study presents a rare case of 13 year old boy who was diagnosed with isolated IGF. This diagnosis has been based on clinical examination and after ruling out family, drug, and medical histories. External bevel gingivectomy has been done to remove excess gingival tissues. Excised tissue has been examined histologically. The patient has been followed up for a period of two and half years. No recurrence has been observed.

  1. Primary or recurring extra-abdominal desmoid fibromatosis: assessment of treatment by observation only.

    Science.gov (United States)

    Barbier, O; Anract, P; Pluot, E; Larouserie, F; Sailhan, F; Babinet, A; Tomeno, B

    2010-12-01

    Extra-abdominal desmoid fibromatosis (EADF) is a benign tumoral condition, classically managed by more or less radical and sometimes mutilating excision. This treatment strategy is associated with a recurrence rate of nearly 50% according to various reports. EADF may show spontaneous stabilization over time. A retrospective series of 26 cases of EADF managed by simple observation was studied to assess spontaneous favorable evolution and identify possible factors impacting evolution. Eleven cases were of primary EADF with no treatment or surgery, and 15 of recurrence after surgery with no adjuvant treatment. MRI was the reference examination during follow-up. Twenty-four cases showed stabilization at a median 14 months; there were no cases of renewed evolution after stabilization. One primary tumor showed spontaneous regression, and one recurrence still showed evolution at end of follow-up (23 months). The sole factor impacting potential for evolution was prior surgery. No radiologic or pathologic criteria of evolution emerged from analysis. The present series, one of the largest dedicated to EADF managed by observation, confirmed recent literature findings: a conservative "wait-and-see" attitude is reasonable and should be considered when large-scale resection would entail significant functional or esthetic impairment. Level IV, retrospective study. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  2. Spontaneous isolated mesenteric fibromatosis: sonographic and computed tomographic findings with pathologic correlation.

    Science.gov (United States)

    Ko, Sheung-Fat; Lin, Jui-Wei; Ng, Shu-Hang; Huang, Chung-Cheng; Wan, Yung-Liang; Huang, Hsuan-Ying; Sheen-Chen, Shyr-Ming

    2006-08-01

    Eight cases of spontaneous isolated mesenteric fibromatosis (SIMF) were retrospectively reviewed. Clinical presentations included palpable abdominal mass (n = 6), abdominal pain (n = 4), gastrointestinal bleeding (n = 2) and acute abdomen (n = 1). On sonography and computed tomography (CT), eight SIMFs (size range 3 to 24 cm, mean 14.8 cm) were categorized into four morphologic patterns: well-defined inhomogeneous, well-defined homogeneous, well-defined cystic or infiltrative mesenteric mass patterns. Well-defined inhomogeneous SIMF (n = 3) was correlated with the histopathologic finding of bundles of fibroblasts with unevenly intermingled hyaline and/or myxoid degeneration areas, whereas well-defined homogeneous SIMF (n = 2) showed scarce degenerative changes. Well-defined cystic SIMF (n = 2) were ascribed to the presence of large areas of myxoid and cystic degenerations. One SIMF presented as an infiltrative mesenteric mass and the patient died 10 months after diagnosis. Both cases of cystic SIMFs showed tumor recurrences and one patient died after 84 months. The other five patients were cured by radical tumor resection. In summary, sonography, similar to CT, is also useful for evaluating SIMF with protean morphologic features, ascribing to the underlying histopathologic changes with varied degrees of hyaline, myxoid or cystic degenerations.

  3. [The use of magnetic resonance imaging in the diagnosis of plantar fibromatosis: a case report].

    Science.gov (United States)

    Halefoğlu, Ahmet Mesrur

    2005-01-01

    Plantar fibromatosis is a benign but infiltrative neoplasm, presenting as a slow-growing nodular thickening most often within the central band of the plantar aponeurosis. In this case report, we presented a 43-year-old male patient who had a tender nodule in the sole of the right foot for two years. On magnetic resonance images, the location and signal intensity characteristics of the lesion were suggestive of plantar fibromatosis, which was histologically confirmed following an incisional biopsy. Magnetic resonance imaging is a noninvasive method for confirmation of the clinical diagnosis of plantar fibromatosis and also has an important role in planning surgical treatment by delineating the extent of the lesion.

  4. Fibromatosis associated with silicone breast implant: ultrasonography and MR imaging findings.

    Science.gov (United States)

    Shim, Hyun Seok; Kim, Seon-Jeong; Kim, Ok Hwa; Jung, Hyun Kyung; Kim, Suk Jung; Kim, Woogyeong; Kim, Woon Won

    2014-01-01

    Desmoid type fibromatosis is an uncommon benign disease entity of which its etiology is currently unknown. It constitutes 0.3% of all solid neoplasms, but it is rarely seen in the breast and even more scarcely reported to develop in association with breast implant. We present ultrasonography and magnetic resonance imaging findings of a 29-year-old female patient with fibromatosis after breast implant surgery. Knowledge of imaging findings of breast fibromatosis associated with implant will be helpful for accurate diagnosis and appropriate management. © 2014 Wiley Periodicals, Inc.

  5. CT findings of solitary fibromatosis in the colon: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Heo, So Young; Lim, Jae Hoon; Kang, Kyung A; Lee, Jeong Ju [Myongji Hospital, Seonam University College of Medicine, Goyang (Korea, Republic of)

    2016-07-15

    Fibromatosis is a rare benign neoplasm that appears as a sporadic lesion or is found in patients with familial adenomatous polyposis. Fewer than 7 cases of intraabdominal solitary fibromatosis arising from the colon have been reported in the English literature. This small number of reported cases may be not only because of the low incidence of the disease but also because of the difficulty in making proper diagnosis. We present here a case of histologically confirmed intraabdominal solitary fibromatosis arising from the colon, with an emphasis on computed tomography findings.

  6. Pediatric fibromatosis involving mandible: case reportand a five-year post-operative follow-up

    Directory of Open Access Journals (Sweden)

    Vilson Lacerda Brasileiro Junior

    2013-06-01

    Full Text Available Extra-abdominal fibromatosis is a benign fibrous neoplasm of locally aggressive behavior. Surgical excision with a wide margin is the treatment of choice. The aim of the present work is to report the case of fibromatosis in an 11-year-old melanodermic patient, who showed swelling in the area of the right mandible. Conservative surgery was performed based on the initial histopathological diagnosis of benign lesion suggestive of neural origin. The new anatomopathological examination of the surgical specimen was compatible with fibromatosis. The patient is still under periodic observation as part of the five-year surgical follow-up, showing no signs of recurrence.

  7. Fibromatosis in a young Bernese Mountain Dog: clinical, imaging, and histopathological findings.

    Science.gov (United States)

    Welle, Monika M; Sutter, Esther; Malik, Yasminda; Konar, Martin; Rüfenacht, Silvia; Howard, Judith E K

    2009-11-01

    A young, intact, male Bernese Mountain Dog was presented to the animal hospital for lameness and diffuse thickening of the soft tissue in the right hind limb. Magnetic resonance imaging revealed multiple, multilobular, space-occupying lesions within and between the muscles of the right femur. Biopsies taken from the lesions revealed an infiltrative mass composed mainly of collagen fibers and a low density of benign-appearing fibroblasts. These findings were compatible with a diagnosis of a fibromatosis. Taking the age of onset into account, infantile fibromatosis was most likely. A deep fibromatosis, similar to that seen in adults, could not be excluded based on histology.

  8. Long-Term Follow-Up of Desmoid Fibromatosis Treated with PF-03084014, an Oral Gamma Secretase Inhibitor.

    Science.gov (United States)

    Villalobos, Victor Manuel; Hall, Francis; Jimeno, Antonio; Gore, Lia; Kern, Kenneth; Cesari, Rossano; Huang, Bo; Schowinsky, Jeffrey T; Blatchford, Patrick Judson; Hoffner, Brianna; Elias, Anthony; Messersmith, Wells

    2017-09-08

    Desmoid fibromatosis is a fibroblastic neoplasm driven by aberrations within the WNT pathway, exhibiting mutations in β-catenin or APC. We review the long-term follow-up of patients in a phase I study treated with an oral gamma secretase inhibitor, PF-03084014. PF-03084014 was administered orally at doses ranging from 20 to 330 mg twice daily. Tumor assessments were performed using computed tomography/magnetic resonance imaging (CT/MRI) within 4 weeks of study entry, and every other cycle through cycle 9. After cycle 9, patients were evaluated as clinically indicated. Seven patients with desmoid fibromatosis were treated between December 2009 and December 2016 at the University of Colorado. Five patients (71.4%, 95% confidence interval [CI] 29.0-96.3%) achieved a partial response (PR), with a mean time to achieving response of 11.9 months (95% CI 2.5-21.4 months). All patients who achieved a PR continue to maintain responses between 47.9 and 73+ months. Four patients stopped treatment yet remain free of progression between 11 and 53+ months. One patient had PFS of 42+ months, with a 17% decrease in the target lesion. A biopsy performed at the end of the study showed decreased tumoral cellularity compared with previous biopsies. Effective treatment doses ranged from 80 to 330 mg administered orally twice daily. PF-03084014 was effective in treating desmoid tumors, with an objective response rate of 71.4% (95% CI 29.0-96.3%) in this small cohort of patients. PF-03084014 exhibits promising activity, even at relatively low doses (80 mg twice daily), with high tolerability leading to prolonged disease control even after therapy discontinuation.

  9. Tumorer

    DEFF Research Database (Denmark)

    Prause, J.U.; Heegaard, S.

    2005-01-01

    oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer......oftalmologi, øjenlågstumorer, conjunctivale tumorer, malignt melanom, retinoblastom, orbitale tumorer...

  10. Desmoid Tumor of the Anterior Abdominal Wall in Female Patients: Comparison with Endometriosis

    Directory of Open Access Journals (Sweden)

    H. Krentel

    2012-01-01

    Full Text Available In female patients presenting a tumor of the lower abdominal wall especially after cesarian section, an endometriotic tumor as well as an aggressive desmoid tumor should be considered. Symptoms in correlation with the monthly period can facilitate the presurgical differentiation between endometriosis and fibromatosis. Ultrasound reveals the typical location of both tumors and its remarkable sonographic appearance. In the clinical practice, the desmoid fibromatosis of the lower abdominal wall is a very rare disease. We present a case of a 25-year-old pregnant and discuss diagnostic and therapeutic options by a PubMed literature review. With the knowledge of the prognosis of the desmoid fibromatosis and the respective treatment options including wait and see, complete surgical resection with macroscopically free margins and adjuvant approaches is essential to avoid further interventions and progression of the locally destructive tumor.

  11. Nonsurgical treatment of aggressive fibromatosis in the head and neck

    Energy Technology Data Exchange (ETDEWEB)

    West, C.B. Jr.; Shagets, F.W.; Mansfield, M.J. (Wilford Hall USAF Medical Center, Lackland Air Force Base, TX (USA))

    1989-09-01

    Aggressive fibromatosis is a poorly defined, locally aggressive, yet histologically benign fibroblastic proliferative lesion that may occur in the head and neck. The lesion is highly cellular and locally infiltrative and has a propensity to invade and erode bone, compromising vital structures within the head and neck. However, it is not a true malignancy because it does not have malignant cytologic characteristics nor does it metastasize. We present two cases of aggressive fibromatosis occurring in young adult men. The first case involved a rapidly enlarging mass of the anterior maxilla that involved the upper lip, nasal alae, nasal septum, inferior turbinates, and hard palate. The patient underwent incisional biopsy to confirm the diagnosis. Because of difficulty in determining the actual margins of this extensive lesion and the significant morbidity that would have resulted from surgical resection, we elected to treat this patient with chemotherapy and radiation therapy. The second case was an extensive lesion involving the right temporal bone, pterygomaxillary space, and infratemporal, temporal, and middle cranial fossae. Incisional biopsy confirmed the diagnosis. Because of the lack of functional and cosmetic deficits and the unavoidable morbidity of a surgical resection, this patient was treated with radiation therapy. Although wide field resection is the most satisfactory form of treatment, in situations in which this modality would result in unacceptable morbidity or if surgical margins are positive, then radiation therapy and chemotherapy should be considered. Support for these therapeutic modalities is found in larger series of cases outside the head and neck.

  12. Gingival fibromatosis with hypertrichosis syndrome: Case series of rare syndrome

    Directory of Open Access Journals (Sweden)

    Preetha Balaji

    2017-01-01

    Full Text Available Gingival fibromatosis with hypertrichosis syndrome is an extremely rare genetic condition characterized by profound overgrowth of hair and gums, as well as other variable features. Gingival fibromatosis is characterized by a large increase in the gingival dimension which extends above the dental crowns, covering them partially or completely. They were found to have a genetic origin, may also occur in isolation or be part of a syndrome, or acquired origin, due to specific drugs administered systemically. Congenital generalized hypertrichosis is a heterogeneous group of diseases with continuing excessive growth of terminal hair without androgenic stimulation. It has informally been called werewolf syndrome because the appearance is similar to that of a werewolf. Various syndromes have been associated with these features such as epilepsy, mental retardation, cardiomegaly, or osteochondrodysplasia. As so far very few cases have been reported in literature, we are reporting a series of three cases with management of the same. The excess gingival tissues, in these cases, were removed by conventional gingivectomy under general anesthesia. The postoperative result was uneventful and the patient's appearance improved significantly. Good esthetic result was achieved to allow patient to practice oral hygiene measures. Though this is not a serious condition clinically, psychosocial trauma cannot be neglected owing to the cosmetic disfigurement it produces.

  13. Ledderhose disease: a case report with palmar fibromatosis, keloid and partial response to oral retinoid

    Directory of Open Access Journals (Sweden)

    Sadr Eshkevari Shahriar

    2015-01-01

    Full Text Available Ledderhose disease is a rare hyperproliferative disorder of fibrous tissue. We present the case of a 40-year-old man who presented with bilateral plantar fibromatosis, dupuytren contracture and keloid, with partial response to oral acitretin.

  14. Ledderhose disease: a case report with palmar fibromatosis, keloid and partial response to oral retinoid

    OpenAIRE

    Sadr Eshkevari Shahriar; Nickhah Nahid

    2015-01-01

    Ledderhose disease is a rare hyperproliferative disorder of fibrous tissue. We present the case of a 40-year-old man who presented with bilateral plantar fibromatosis, dupuytren contracture and keloid, with partial response to oral acitretin.

  15. Cicatricial Fibromatosis Diagnosis after Suspected Local Recurrence at the Bronchial Stump Following Lobectomy for Lung Cancer.

    Science.gov (United States)

    Hwang, Wan Jin; Lee, Yeiwon; Jung, Soo Young; Yeh, Daewook; Park, Soon Hyo; Yoon, Yoo Sang

    2016-04-01

    A mass excision surrounding the bronchial stump was performed to exclude malignancy in a 42-year-old man who had undergone a right lower lobectomy for lung cancer. The mass was identified as a cicatricial fibroma. Cicatricial fibromatosis, which is desmoid fibromatosis that arises in a surgical scar, is a well-known clinical condition. It consists of histologically benign neoplasms. Their occurrence after thoracic surgery is extremely rare. Biopsy or excision of suspicious lesions is very important for diagnosis. R0 resection remains the principal outcome for intra-thoracic desmoid fibromatosis. We report that a cicatricial fibromatosis in the subcarinal space was removed after suspicion of local recurrence at the bronchial stump follwing lobectomy for lung cancer.

  16. Increased expression of collagen prolyl 4-hydroxylases in Chinese patients with hereditary gingival fibromatosis.

    NARCIS (Netherlands)

    Meng, L.; Huang, M.; Ye, X.; Fan, M.; Bian, Z.

    2007-01-01

    OBJECTIVES: Hereditary gingival fibromatosis (HGF) is characterized by excess accumulation of interstitial collagen. However, until now, there has been controversy about the mechanism of collagen accumulation in HGF gingivae. The present study aimed to clarify the pathogenic mechanisms potentially i

  17. Vemurafenib-associated Dupuytren- and Ledderhose palmoplantar fibromatosis in metastatic melanoma patients.

    Science.gov (United States)

    Vandersleyen, V; Grosber, M; Wilgenhof, S; De Kock, J; Neyns, B; Gutermuth, J

    2016-07-01

    The BRAF-inhibitor vemurafenib, used in patients with metastatic melanoma, induces multiple cutaneous side-effects. The aim of this work was to evaluate the development of palmoplantar fibromatosis in a population of patients treated with the BRAF inhibitor vemurafenib. Between April 2011 and February 2013, we initiated a treatment with vemurafenib in 53 patients with an unresectable stage IIIC or stage IV melanoma. The patients were followed-up on a regular base to monitor possible side-effects. A plantar or palmar fibromatosis was observed in five of 53 patients treated with vemurafenib. In four of these patients other risk factors for the development of palmoplantar fibromatosis were absent. The BRAF-inhibitor vemurafenib might induce palmoplantar fibromatosis. © 2015 European Academy of Dermatology and Venereology.

  18. Increased expression of collagen prolyl 4-hydroxylases in Chinese patients with hereditary gingival fibromatosis.

    NARCIS (Netherlands)

    Meng, L.; Huang, M.; Ye, X.; Fan, M.; Bian, Z.

    2007-01-01

    OBJECTIVES: Hereditary gingival fibromatosis (HGF) is characterized by excess accumulation of interstitial collagen. However, until now, there has been controversy about the mechanism of collagen accumulation in HGF gingivae. The present study aimed to clarify the pathogenic mechanisms potentially i

  19. RF tumor ablation with internally cooled electrodes and saline infusion: what is the optimal location of the saline infusion?

    Directory of Open Access Journals (Sweden)

    Cruz Ignacio

    2007-07-01

    Full Text Available Abstract Background Radiofrequency ablation (RFA of tumors by means of internally cooled electrodes (ICE combined with interstitial infusion of saline may improve clinical results. To date, infusion has been conducted through outlets placed on the surface of the cooled electrode. However, the effect of infusion at a distance from the electrode surface is unknown. Our aim was to assess the effect of perfusion distance (PD on the coagulation geometry and deposited power during RFA using ICE. Methods Experiments were performed on excised bovine livers. Perfusion distance (PD was defined as the shortest distance between the infusion outlet and the surface of the ICE. We considered three values of PD: 0, 2 and 4 mm. Two sets of experiments were considered: 1 15 ablations of 10 minutes (n ≥ 4 for each PD, in order to evaluate the effect of PD on volume and diameters of coagulation; and 2 20 additional ablations of 20 minutes. The effect of PD on deposited power and relative frequency of uncontrolled impedance rises (roll-off was evaluated using the results from the two sets of experiments (n ≥ 7 for each PD. Comparisons between PD were performed by analysis of variance or Kruskal-Wallis test. Additionally, non-linear regression models were performed to elucidate the best PD in terms of coagulation volume and diameter, and the occurrence of uncontrolled impedance rises. Results The best-fit least square functions were always obtained with quadratic curves where volume and diameters of coagulation were maximum for a PD of 2 mm. A thirty per cent increase in volume coagulation was observed for this PD value compared to other values (P Conclusion Saline perfusion at around 2 mm from the electrode surface while using an ICE in RFA improves deposition of energy and enlarges coagulation volume.

  20. High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose’s disease)

    OpenAIRE

    Knobloch, Karsten; Peter M Vogt

    2012-01-01

    Background Plantar fibromatosis is a benign disease creating nodules on the medial plantar side of affected patients. While surgical removal is regarded as the therapeutic mainstay, recurrence rates and impairment of daily activities remains substantial. High-energy focussed extracorporeal shockwave therapy has been suggested to be potentially effective in plantar fibromatosis in terms of pain reduction. Hypothesis High-energy focussed extracorporeal shockwave therapy reduces pain in plantar ...

  1. Mesenteric fibromatosis with spontaneous cystic degeneration: a case report with US and CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Seog Wan; Lee, Ji Shin [Medical College, Seonam Univ., Kwangju (Korea, Republic of)

    2002-05-01

    Mesenteric fibromatosis is an uncommon benign neoplasm occurring in the mesentery or retroperitoneum, and presenting as a firm mass with infiltrative margins and homogeneous parenchyma without necrosis or a cystic component (1-4). Cystic change may occur, usually after prolonged medical treatment, but is extremely rare (5-7). We describe the US and CT findings in a case of mesenteric fibromatosis with spontaneous extensive cystic degeneration.

  2. A case of thyroid fibromatosis, a rare lesion of this gland

    Science.gov (United States)

    Cabrera, Rafael Adame; Leite, Valeriano

    2016-01-01

    Summary Thyroid fibromatosis is a very rare lesion; to our knowledge, there are only four cases reported in the medical literature. Herein, we report the clinical case of a woman with thyroid fibromatosis with a long follow-up (11 years). A 63-year-old female patient, with an increasing multinodular goitre without compressive symptoms, was admitted to total thyroidectomy. The histology revealed a spindle-cell proliferation with fibroblastic characteristics with no atypia and thin capillary vessels. Immunohistochemistry was positive for beta-catenin, focally to desmin and alfa-actin and negative for cytokeratins and CD34. Thyroid cells did not display any features of papillary thyroid cancer. These characteristics were compatible with thyroid fibromatosis. For the past 11 years, the patient has been periodically followed up with neck CTs and she has not shown any signs of recurrence. Thyroid fibromatosis has been associated with invasion of surrounding structures in previous reported cases. However, this aggressive behaviour was not observed in our patient. The most challenging differential diagnosis is with papillary thyroid cancer with fibromatosis-like stroma, in which the malignant component is usually peripheral. Therefore, in these cases, it is mandatory to perform an extensive examination of the resected sample. Learning points: Fibromatosis is a mesenchymal lesion that consists of an infiltrative proliferation of fibroblasts without atypia. Thyroid fibromatosis is a rare entity in this gland. In previously reported cases, it has been associated with an invasive behaviour but this was not the case in our patient. When spindle-cell proliferation with fibroblastic/myofibroblastic characteristics is detected on thyroid histology, it is mandatory to exclude a papillary thyroid carcinoma with fibromatosis-like stroma. PMID:27855230

  3. Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice.

    Directory of Open Access Journals (Sweden)

    Jung-Pan Wang

    Full Text Available Musculoskeletal fibromatosis remains a disease of unknown etiology. Surgical excision is the standard of care, but the recurrence rate remains high. Superficial fibromatosis typically presents as subcutaneous nodules caused by rapid myofibroblast proliferation followed by slow involution to dense acellular fibrosis. In this study, we demonstrate that fibromatosis stem cells (FSCs can be isolated from palmar nodules but not from cord or normal palm tissues. We found that FSCs express surface markers such as CD29, CD44, CD73, CD90, CD105, and CD166 but do not express CD34, CD45, or CD133. We also found that FSCs are capable of expanding up to 20 passages, that these cells include myofibroblasts, osteoblasts, adipocytes, chondrocytes, hepatocytes, and neural cells, and that these cells possess multipotentiality to develop into the three germ layer cells. When implanted beneath the dorsal skin of nude mice, FSCs recapitulated human fibromatosis nodules. Two weeks after implantation, the cells expressed immunodiagnostic markers for myofibroblasts such as α-smooth muscle actin and type III collagen. Two months after implantation, there were fewer myofibroblasts and type I collagen became evident. Treatment with the antifibrogenic compound Trichostatin A (TSA inhibited the proliferation and differentiation of FSCs in vitro. Treatment with TSA before or after implantation blocked formation of fibromatosis nodules. These results suggest that FSCs are the cellular origin of fibromatosis and that these cells may provide a promising model for developing new therapeutic interventions.

  4. Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice.

    Science.gov (United States)

    Wang, Jung-Pan; Hui, Yun-Ju; Wang, Shih-Tien; Yu, Hsiang-Hsuan Michael; Huang, Yi-Chao; Chiang, En-Rung; Liu, Chien-Lin; Chen, Tain-Hsiung; Hung, Shih-Chieh

    2011-01-01

    Musculoskeletal fibromatosis remains a disease of unknown etiology. Surgical excision is the standard of care, but the recurrence rate remains high. Superficial fibromatosis typically presents as subcutaneous nodules caused by rapid myofibroblast proliferation followed by slow involution to dense acellular fibrosis. In this study, we demonstrate that fibromatosis stem cells (FSCs) can be isolated from palmar nodules but not from cord or normal palm tissues. We found that FSCs express surface markers such as CD29, CD44, CD73, CD90, CD105, and CD166 but do not express CD34, CD45, or CD133. We also found that FSCs are capable of expanding up to 20 passages, that these cells include myofibroblasts, osteoblasts, adipocytes, chondrocytes, hepatocytes, and neural cells, and that these cells possess multipotentiality to develop into the three germ layer cells. When implanted beneath the dorsal skin of nude mice, FSCs recapitulated human fibromatosis nodules. Two weeks after implantation, the cells expressed immunodiagnostic markers for myofibroblasts such as α-smooth muscle actin and type III collagen. Two months after implantation, there were fewer myofibroblasts and type I collagen became evident. Treatment with the antifibrogenic compound Trichostatin A (TSA) inhibited the proliferation and differentiation of FSCs in vitro. Treatment with TSA before or after implantation blocked formation of fibromatosis nodules. These results suggest that FSCs are the cellular origin of fibromatosis and that these cells may provide a promising model for developing new therapeutic interventions.

  5. High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose's disease).

    Science.gov (United States)

    Knobloch, Karsten; Vogt, Peter M

    2012-10-02

    Plantar fibromatosis is a benign disease creating nodules on the medial plantar side of affected patients. While surgical removal is regarded as the therapeutic mainstay, recurrence rates and impairment of daily activities remains substantial. High-energy focussed extracorporeal shockwave therapy has been suggested to be potentially effective in plantar fibromatosis in terms of pain reduction. High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis. A total number of six patients (5 males, 58±4 years) were included with plantar fibromatosis (Ledderhose's disease) associated with pain. Three patients were operated on previously, one had concomitant Dupuytren's contracture. High-energy focussed ESWT was applied using a Storz Duolith SD1 (2000 impulses, 3 Hz, 1.24 mJ/mm²) in two sessions with 7 days between. Pain was 6±2 at baseline, 2±1 after 14 days and 1±1 after 3 months. Softening of the nodules was noted by all patients. No adverse effects were noted. High-energy focussed extracorporeal shockwave energy reduces pain in painful plantar fibromatosis (Morbus Ledderhose). Further large-scale prospective trials are warranted to elucidate the value of high-energy focussed extracorporeal shockwave therapy (ESWT) in plantar fibromatosis in terms of recurrence and efficacy.

  6. High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis (Ledderhose’s disease)

    Science.gov (United States)

    2012-01-01

    Background Plantar fibromatosis is a benign disease creating nodules on the medial plantar side of affected patients. While surgical removal is regarded as the therapeutic mainstay, recurrence rates and impairment of daily activities remains substantial. High-energy focussed extracorporeal shockwave therapy has been suggested to be potentially effective in plantar fibromatosis in terms of pain reduction. Hypothesis High-energy focussed extracorporeal shockwave therapy reduces pain in plantar fibromatosis. Findings A total number of six patients (5 males, 58±4 years) were included with plantar fibromatosis (Ledderhose’s disease) associated with pain. Three patients were operated on previously, one had concomitant Dupuytren’s contracture. High-energy focussed ESWT was applied using a Storz Duolith SD1 (2000 impulses, 3 Hz, 1.24 mJ/mm2) in two sessions with 7 days between. Pain was 6±2 at baseline, 2±1 after 14 days and 1±1 after 3 months. Softening of the nodules was noted by all patients. No adverse effects were noted. Conclusions High-energy focussed extracorporeal shockwave energy reduces pain in painful plantar fibromatosis (Morbus Ledderhose). Further large-scale prospective trials are warranted to elucidate the value of high-energy focussed extracorporeal shockwave therapy (ESWT) in plantar fibromatosis in terms of recurrence and efficacy. PMID:23031080

  7. Positron emission tomography in patients with aggressive fibromatosis/desmoid tumours undergoing therapy with imatinib

    Energy Technology Data Exchange (ETDEWEB)

    Kasper, Bernd; Hohenberger, Peter [University of Heidelberg, Sarcoma Unit, ITM - Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, Mannheim (Germany); Dimitrakopoulou-Strauss, Antonia; Strauss, Ludwig G. [German Cancer Research Center, Clinical Cooperation Unit Nuclear Medicine, Heidelberg (Germany)

    2010-10-15

    We used {sup 18}F-FDG PET to evaluate the FDG uptake in patients with aggressive fibromatosis (AF, also known as desmoid tumours) undergoing therapy with imatinib (imatinib mesylate, Glivec). The pilot study included nine patients with progressive AF receiving oral treatment with imatinib at a daily dose of 800 mg. Patients were examined using PET prior to the start of therapy and during imatinib treatment. Restaging according to the Response Evaluation Criteria in Solid Tumors (RECIST) was performed in parallel using CT and/or MRI and served as reference. The clinical outcomes in nine evaluable patients were as follows: seven patients with stable disease, and two patients with progressive disease. A 27% decrease in the median average standardized uptake value (SUV) of the sequential PET examinations was demonstrated in all evaluable patients with three patients (33%) showing a decrease in SUV of more than 40% (48%, 52% and 54%, respectively); no patient showed a substantial increase in SUV. To our knowledge, this is the first series of AF patients undergoing treatment with imatinib and monitored using sequential PET imaging, that allows detection of SUV changes after imatinib induction, thus helping to decide whether treatment should be continued or not. (orig.)

  8. Diagnosis and treatment of a hereditary gingival fibromatosis case.

    Science.gov (United States)

    Zhou, Min; Xu, Li; Meng, Huan Xin

    2011-01-01

    Hereditary gingival fibromatosis (HGF) is a rare condition characterised by severe gingival hyperplasia, which could result in serious aesthetic and emotional problems and functional impairment. Here the present authors report a case of a 28-year-old female patient with generalised severe gingival enlargement covering almost all of the teeth and diagnosed as HGF. Her family history was of significance, since her father and 3-year-old daughter suffered from the same symptoms. Many studies have agreed that surgical removal should be used in the treatment of HGF, and gingivectomy is the most common method. This study tried both external and internal bevel incisions. The results suggest that the former is better for shaping gingival contour, if the attached gingiva is adequate. Correct physiological contour of the marginal gingiva, good oral hygiene and periodic recall can decrease recurrence risk. Post-surgical follow-up after 26 months demonstrated no recurrence and the patient was satisfied with her appearance.

  9. Imaging evalution of the gingival fibromatosis and dental abnormalities syndrome

    Science.gov (United States)

    dos Santos Neto, PE; dos Santos, LAN; Coletta, RD; Laranjeira, AL; de Oliveira Santos, CC; Bonan, PR; Martelli-Júnior, H

    2011-01-01

    Objective The purpose of this study was to evaluate the dentomaxillofacial imaging features of one family affected by the gingival fibromatosis (GF) and dental abnormalities (DA) syndrome. Methods Conventional radiographs (periapical and panoramic) and cone beam CT (CBCT) were performed in nine members of this family: four were affected by the syndrome and five were not. Results The four affected members demonstrated mild generalized GF in association with DA, including hypoplastic amelogenesis imperfecta, intrapulpal calcifications, delay on tooth eruption and pericoronal radiolucencies in unerupted teeth. None of these oral changes were identified in the five unaffected members. All nine members presented alterations in the paranasal sinuses and mucosal thickening of the maxillary sinus was the most common finding. Conclusion Family members not affected by the syndrome showed similar alterations in the paranasal sinuses and CBCT was useful to characterize the dentomaxillofacial features of this new syndrome associating GF and DA. PMID:21493880

  10. [Extra-abdominal desmoid tumors. Case report and literature review].

    Science.gov (United States)

    Ridders, J; Ernst, A; Todt, I; Seidl, R O

    2005-07-01

    Musculoaponeurotic fibromatosis or desmoid tumors are rare. We report the case of a 57 year old woman with a slowly growing tumor behind the sternocleidomastoid muscle, which was completely removed. Histological examination confirmed the clinical suspicion of a desmoid tumor. Desmoid tumors are aggressive, locally infiltrating, non-metastasizing tumors with a high local recurrence. Genetic, endocrine and physical factors have been implicated as causative agents. The diagnosis is made histologically, reactive fibromatosis and fibrosarcoma must be eliminated in differential diagnosis. By the combination of different radiographic techniques, it is possible to describe the tumors and differentiate between vessels, nerves and bones. The therapy of the choice is the surgical resection. Adjuvant therapy, such as x-ray treatment, chemo- and hormone therapy, are indicated when the tumor is inoperable or too extensive for surgery.

  11. RF transformer

    Science.gov (United States)

    Smith, James L.; Helenberg, Harold W.; Kilsdonk, Dennis J.

    1979-01-01

    There is provided an improved RF transformer having a single-turn secondary of cylindrical shape and a coiled encapsulated primary contained within the secondary. The coil is tapered so that the narrowest separation between the primary and the secondary is at one end of the coil. The encapsulated primary is removable from the secondary so that a variety of different capacity primaries can be utilized with one secondary.

  12. High frequency of beta-catenin heterozygous mutations in extra-abdominal fibromatosis: a potential molecular tool for disease management.

    Science.gov (United States)

    Dômont, J; Salas, S; Lacroix, L; Brouste, V; Saulnier, P; Terrier, P; Ranchère, D; Neuville, A; Leroux, A; Guillou, L; Sciot, R; Collin, F; Dufresne, A; Blay, J-Y; Le Cesne, A; Coindre, J-M; Bonvalot, S; Bénard, J

    2010-03-16

    Fibromatosis comprises distinct clinical entities, including sporadic extra-abdominal fibromatosis, which have a high tendency for recurrence, even after adequate resection. There are no known molecular biomarkers of local recurrence. We searched for beta-catenin mutations in a European multicentre series of fibromatosis tumours to relate beta-catenin mutational status to disease outcome. Direct sequencing of exon 3 beta-catenin gene was performed for 155 frozen fibromatosis tissues from all topographies. Correlation of outcome with mutation rate and type was performed on the extra-abdominal fibromatosis group (101 patients). Mutations of beta-catenin were detected in 83% of all cases. Among 101 extra-abdominal fibromatosis, similar mutation rates (87%) were observed, namely T41A (39.5%), S45P (9%), S45F (36.5%), and deletion (2%). None of the clinico-pathological parameters were found to be significantly associated with beta-catenin mutational status. With a median follow-up of 62 months, 51 patients relapsed. Five-year recurrence-free survival was significantly worse in beta-catenin-mutated tumours regardless of a specific genotype, compared with wild-type tumours (49 vs 75%, respectively, P=0.02). A high frequency (87%) of beta-catenin mutation hallmarks extra-abdominal fibromatosis from a large multicentric retrospective study. Moreover, wild-type beta-catenin seems to be an interesting prognostic marker that might be useful in the therapeutic management of extra-abdominal fibromatosis.

  13. Breast Fibromatosis after Hydrophilic Polyacrylamide Gel Injection for Breast Augmentation: a Case Report and Review of the Literature

    Institute of Scientific and Technical Information of China (English)

    Xiao Long; Qun Qiao

    2011-01-01

    @@ BREAST fibromatosis is a rare kind of lesion.The average incidence is about 2-4 per million every year.1 So far there have been about 100 cases reported altogether.2 In this report, we describe a case of breast fibromatosis developed after hydrophilic polyacrylamide gel (HPG) injection for breast augmenta-Received for publication December 10, 2010.

  14. Fibroblastic and myofibroblastic tumors of the head and neck: Comprehensive imaging-based review with pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Hourani, Roula, E-mail: rh64@aub.edu.lb [Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut (Lebanon); Taslakian, Bedros, E-mail: bt05@aub.edu.lb [Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut (Lebanon); Shabb, Nina S., E-mail: ns04@aub.edu.lb [Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut (Lebanon); Nassar, Lara, E-mail: ln07@aub.edu.lb [Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut (Lebanon); Hourani, Mukbil H., E-mail: mh17@aub.edu.lb [Department of Diagnostic Radiology, American University of Beirut Medical Center, Beirut (Lebanon); Moukarbel, Roger, E-mail: rm17@aub.edu.lb [Department of Otolaryngology – Head and Neck Surgery, American University of Beirut Medical Center, Beirut (Lebanon); Sabri, Alain, E-mail: as71@aub.edu.lb [Department of Otolaryngology – Head and Neck Surgery, American University of Beirut Medical Center, Beirut (Lebanon); Rizk, Toni, E-mail: tonirisk@hotmail.com [Department of Neurosurgery, Hôtel-Dieu de France, Saint-Joseph University, Beirut (Lebanon)

    2015-02-15

    Highlights: • Almost all fibroblastic tumors are evaluated with non-invasive imaging. • Radiologists should be familiar with the imaging appearance of fibroblastic tumors. • Most appropriate initial examination when fibromatosis coli suspected is ultrasound. • Most common location of ossifying fibromas is the tooth-bearing regions. - Abstract: Fibroblastic and myofibroblastic tumors of the head and neck are a heterogeneous group of disorders characterized by the proliferation of fibroblasts, myofibroblasts, or both. These tumors may be further subclassified on the basis of their behavior as benign, intermediate with malignant potential, or malignant. There are different types of fibroblastic and myofibroblastic tumors that can involve the head and neck including desmoid-type fibromatosis, solitary fibrous tumor, myofibroma/myofibromatosis, nodular fasciitis, nasopharyngeal angiofibroma, fibrosarcoma, dermatofibrosarcoma protuberans, fibromatosis coli, inflammatory myofibroblastic tumor, ossifying fibroma, fibrous histiocytoma, nodular fasciitis, fibromyxoma, hyaline fibromatosis and fibrous hamartoma. Although the imaging characteristics of fibroblastic and myofibroblastic tumors of the head and neck are nonspecific, imaging plays a pivotal role in the noninvasive diagnosis and characterization of these tumors, providing information about the constitution of tumors, their extension and invasion of adjacent structures. Correlation with the clinical history may help limit the differential diagnosis and radiologists should be familiar with the imaging appearance of these tumors to reach an accurate diagnosis.

  15. Recurrence of plantar fibromatosis after plantar fasciectomy: single-center long-term results.

    Science.gov (United States)

    van der Veer, Willem M; Hamburg, Stijn M; de Gast, Arthur; Niessen, Frank B

    2008-08-01

    Plantar fibromatosis is a rare, hyperproliferative, benign lesion of the plantar aponeurosis with an unknown cause. Surgical treatment is associated with a high recurrence rate and risk of complications. The goal of this study was to determine the recurrence rate of plantar fibromatosis after plantar fasciectomy at the authors' institute during the past three decades and the factors associated with an increased risk for recurrence. The study group contained 27 patients with plantar fibromatosis, who underwent 40 operations on 33 feet, including 13 right (39 percent) and 20 left (61 percent) feet. The overall recurrence rate was 60 percent. Treating a primary lesion with total plantar fasciectomy was associated with the lowest (25 percent) and local resection of the lesion was associated with the highest recurrence rate (100 percent). There seemed to be a relation between the existence of multiple nodules in one foot and a higher recurrence rate. The recurrence of a primary lesion treated with fasciectomy combined with postoperative radiotherapy seemed to be lower in comparison with the recurrence rate after surgery only. Surgical treatment of plantar fibromatosis is associated with a high recurrence rate and indicated only when the lesions are highly symptomatic and conservative measures fail. Total plantar fasciectomy is the most successful treatment in this study, particularly for primary lesions. The role of postoperative radiotherapy should be evaluated further. A prospective multicenter study comparing different surgical procedures will be needed to determine the type of operation that most effectively eliminates plantar fibromatosis.

  16. Prevalence of the CTNNB1 mutation genotype in surgically resected fibromatosis of the breast.

    Science.gov (United States)

    Kim, Taeeun; Jung, Eun Ah; Song, Ji Young; Roh, Ji Hyeon; Choi, Jong Sun; Kwon, Jee Eun; Kang, So Young; Cho, Eun Yoon; Shin, Jung Hee; Nam, Suk-Jin; Yang, Jung Hyun; Choi, Yoon-La

    2012-01-01

    To investigate CTNNB1 mutation and β-catenin expression in resected breast fibromatosis and to identify potential molecular markers of fibromatosis of the breast. We selected 12 patients with fibromatosis of the breast who underwent surgical resection and were confirmed by histological examination. Ultrasonography findings for 10 patients were reviewed and only two cases were suspicious for fibromatosis on imaging. On core needle biopsy for pre-operative diagnoses, only three cases were histologically suspicious for fibromatosis. Mutations in exon 3 of CTNNB1 were detected by direct DNA sequencing in nine (75.0%) cases: all were c.121G>A (p.T41A), which was much more frequent in breast fibromatoses than in other soft tissue lesions. Nuclear β-catenin expression was observed in all cases and the level of expression was higher in cases with mutation. In eight of nine cases, the matched biopsy specimen showed the same CTNNB1 mutation status as the pre-operative specimen. In the majority of cases, clinical presentation and breast imaging are highly suspicious for carcinoma. Definitive pre-operative pathological diagnosis by core needle biopsy is difficult. CTNNB1 mutation and nuclear β-catenin expression are frequently detected in sporadic breast fibromatoses, suggesting their potential as a useful tool to distinguish breast fibromatoses from other neoplasms. © 2011 Blackwell Publishing Limited.

  17. The medico-legal observation of an aggressive urogenital fibromatosis with isolated development not related to any traumatic event.

    Science.gov (United States)

    Muccino, Enrico; Gentile, Guendalina; Mantero, Stefano; Marchesi, Matteo; Rancati, Alessandra; Zoja, Riccardo

    2016-03-01

    Desmoid tumor is a fibroproliferative neoplasm with an intermediate malignancy and it can be localized in every bodily district: some locations are considered exceptional, like the urogenital localization. The Author point out a rare case of giant idiopathic scrotal fibromatosis that was found during an autopsy. A widower, that lived alone in poor hygienic conditions, was found dead in his house. The Judicial Authority ordered the autopsy, that was performed two days later at the Medico-Legal Section of Milan University. External examinations revealed only the considerable dimension of the scrotum (cm 24 × 41). The cause of death was fixed in a cardiac tamponade due to a natural heart laceration localized in correspondence of a transmural infarction. The toxicological exam resulted negative, while the histopathological and immunohistochemical analysis qualify the scrotal mass as a desmoids tumor. Due to the absence of predisposing conditions and of fibroproliferative infiltration in bladder and retroperitoneal space, the neoplasm was configured as an idiopathic desmoid tumor. The presented case gives the reason for the discussion concerning medico-legal aspects that are typical of rare neoplasms.

  18. Fibromatosis of the hand associated with EMO syndrome: A Case report

    Directory of Open Access Journals (Sweden)

    Altmeyer Peter

    2004-11-01

    Full Text Available Abstract Background EMO syndrome, defined as a triad including exophthalmus, pretibial myxedema and osteoarthropathia, is a rare condition in patients suffering from hyperthyreosis. Case presentation We here describe an interesting case of EMO syndrome associated with unilateral fibromatosis of the hand and an initial stage of generalized myxedema of the skin. To our knowledge a similar case has not yet been described in literature though reports about associated fibromatosis, e.g. located retroperitoneally, already exist. Familiar explanations include its initiation by autoimmune processes or aberrant T-cell cytokine stimulation leading to an overwhelming production of glycosaminoglycans. Conclusion Interpreting our case in context with previous reports we conclude that associated fibromatosis induced by autoimmune processes may affect a variety of different localizations and therefore requires careful monitoring. A therapeutical attempt by using UVA1 irridation for pretibial myxedema remained without a satisfying regression.

  19. Congenital infantile fibromatosis of the cheek: report of a rare case and differential diagnosis.

    Science.gov (United States)

    Pontes, H A R; Pontes, F S C; e Silva, B T C; Kato, A M B; de Freitas Silva, B S

    2011-11-01

    Infantile fibromatosis is a benign tumour that consists of dense masses of fibroblasts and myofibroblasts with marked collagen production. Although it is a nonmetastasising tumour, it has significant potential for local invasion and recurrence and may be fatal because of its size and location. The authors report an unusual case of infantile fibromatosis of the cheek in an 8-month-old boy, present since birth. The patient underwent surgical treatment with tumour-free margins and the 6-month follow-up revealed no signs of recurrence. Infantile fibromatosis of the cheek is a very rare condition at this location, especially congenital cases. It should be considered in the differential diagnosis of congenital lesions in childhood. Copyright © 2011 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  20. Long-term management of an idiopathic gingival fibromatosis patient with the primary dentition.

    Science.gov (United States)

    Kamolmatyakul, S; Kietthubthew, S; Anusaksathien, O

    2001-01-01

    Gingival fibromatosis is usually seen as an isolated finding or occasionally in association with other features as part of a syndrome. The combination of gingival enlargement, hypertrichosis, epilepsy and mental retardation is also a commonly reported syndrome that features gingival fibromatosis. The following report is about a mentally retarded patient who has shown no sign of hypertrichosis, but has been taking phenobarbital as a long-term therapy drug for anti-convulsion. Long-term management of this patient has been carried out from the age of one-and-a-half years to 14 years old. The patient's clinical features, treatment received, histopathologic presentation of gingival fibromatosis and proper management of the condition are discussed.

  1. [Pseudo-tumoral lesions of dense conjuntival tissue. Attempt at pathogenic interpretation].

    Science.gov (United States)

    Bonenfani, J L; Lagacé, R

    1975-01-01

    The histogenesis of pseudotumors of dense connective tissue has been studied. These lesions may be classified as mucoid (synovial cyst and periungueal myxoma), collagenous (desmoid tumor, desmoid fibroblastoma and fibromatosis colli), elastic (elastofibroma dorsi), cellular (fibroblastic: fibromatosis, fasciitis and myositis; histiocytic: giant-cell tumor of tendon sheath, fibrous histiocytoma and atypical fibroxanthoma), metaplastic (ossifying fasciitis, ossifying myositis and juvenile chondroid fibroma) and hamartomatous nature (fibrous hamartoma). It must be emphasized that these lesions show a variable and polymorphouse cellular composition and then can simulate sarcoma.

  2. Fibromatosis of the plantar fascia: diagnosis and indications for surgical treatment.

    Science.gov (United States)

    Dürr, H R; Krödel, A; Trouillier, H; Lienemann, A; Refior, H J

    1999-01-01

    Plantar fibromatosis is a rare, benign lesion involving the plantar aponeurosis. Eleven patients (13 feet) underwent 24 operations, including local excision, wide excision, or complete plantar fasciectomy. Clinical results were evaluated retrospectively. There were no differences among the subgroups in postoperative complications. Two primary fasciectomies did not recur. Three of six revised fasciectomies, seven of nine wide excisions, and six of seven local excisions recurred. Our results indicate that recurrence of plantar fibromatosis after surgical resection can be reduced by aggressive initial surgical resection.

  3. Juvenile hyaline fibromatosis and infantile systemic hyalinosis: Divergent expressions of the same genetic defect?

    Directory of Open Access Journals (Sweden)

    Dhingra Mandeep

    2008-01-01

    Full Text Available We describe here a three year-old girl with classic clinical and histological features of juvenile hyaline fibromatosis. We found a history of similar skin findings in her eldest sister, in whom the disorder took a rapidly progressive and fatal course in the second year of life, suggesting either a very severe form of juvenile hyaline fibromatosis, or the possibility of infantile systemic hyalinosis. The similarities and differences between these two described types of hyalinoses have been reviewed in reference to the present report.

  4. AKT1 and BRAF mutations in pediatric aggressive fibromatosis.

    Science.gov (United States)

    Meazza, Cristina; Belfiore, Antonino; Busico, Adele; Settanni, Giulio; Paielli, Nicholas; Cesana, Luca; Ferrari, Andrea; Chiaravalli, Stefano; Massimino, Maura; Gronchi, Alessandro; Colombo, Chiara; Pilotti, Silvana; Perrone, Federica

    2016-06-01

    Aside from the CTNNB1 and adenomatous polyposis coli (APC) mutations, the genetic profile of pediatric aggressive fibromatosis (AF) has remained poorly characterized. The aim of this study was to shed more light on the mutational spectrum of pediatric AF, comparing it with its adult counterpart, with a view to identifying biomarkers for use as prognostic factors or new potential therapeutic targets. CTNNB1, APC, AKT1, BRAF TP53, and RET Sanger sequencing and next-generation sequencing (NGS) with the 50-gene Ion AmpliSeq Cancer Hotspot Panel v2 were performed on formalin-fixed samples from 28 pediatric and 33 adult AFs. The prognostic value of CTNNB1, AKT1, and BRAF mutations in pediatric AF patients was investigated. Recurrence-free survival (RFS) curves were estimated with the Kaplan-Meier method and statistical comparisons were drawn using the log-rank test. In addition to the CTNNB1 mutation (64%), pediatric AF showed AKT1 (31%), BRAF (19%), and TP53 (9%) mutations, whereas only the CTNNB1 mutation was found in adult AF. The polymorphism Q472H VEGFR was identified in both pediatric (56%) and adult (40%) AF. Our results indicate that the mutational spectrum of pediatric AF is more complex than that of adult AF, with multiple gene mutations involving not only CTNNB1 but also AKT1 and BRAF. This intriguing finding may have clinical implications and warrants further investigations. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  5. Retroperitoneal fibromatosis:1 case report with literature review%腹膜后纤维瘤病1例报告并文献复习

    Institute of Scientific and Technical Information of China (English)

    代海涛; 刘昌茂; 夏安; 熊鹰; 呙林杰; 刘远华; 郑江; 陈益

    2015-01-01

    目的:探讨腹膜后纤维瘤病临床特点。方法:报道1例腹膜后纤维瘤病侵袭输尿管致严重血尿的诊治,并复习有关文献。结果:术中发现腹膜后右侧输尿管末端有一直径6cm 实性肿瘤,固定于盆壁,与髂外动静脉致密粘连,包裹右侧输尿管末端,上段输尿管扩张。行肿瘤大部切除术+输尿管再植术,切除肿瘤大部分为肌瘤样组织,中间坏死形成囊腔,与输尿管相通;术中快速冰冻片报告梭形细胞肿瘤,良恶性待定;术后病理报告为腹膜后纤维瘤病,免疫组化:CD34(-)、CD117(-)、Dog -1(-)、SMAS -100(-)、Vimentin (+)、Desmin(-)、NSE(-)。结论:腹膜后纤维瘤病是一种十分罕见的软组织肿瘤,可以因发生位置不同而以不同临床症状就诊,提高对这一肿瘤的认识可以减少误诊。%Objective:To investigate the clinical features of retroperitoneal fibromatosis.Methods:Describing and reporting the diagnosis and treatment of a case of retroperitoneal fibromatosis,which was invasive to the right ureter, caused severe hematuria.The literature had been reviewed and discussed.Results:There was a 6cm solid tumor,fixed on the pelvic wall,external iliac vein with dense adhesions,parcel right ureter end,with upper ureteral dilatation.We underwent tumor subtotal +ureteral reimplantation.Most of the tumor were fibroid tissue,necrosis intermediate forma-tion of cysts,which interlinked ureter.Intraoperative frozen section slice reported spindle cell tumors.Postoperative pa-thology reported retroperitoneal fibromatosis.Immunohistochemistry:CD34(-),CD117(-),Dog -1(-),SMAS -100(-),Vimentin(+),Desmin(-),NSE(-).Conclusion:Retroperitoneal fibromatosis is a very rare soft tissue tumor which can occur different clinical symptoms.To improve the understanding of this tumor can reduce misdiagnosis.

  6. Bimaxillary unilateral gingival fibromatosis with localized aggressive periodontitis (eating the tooth at the same table

    Directory of Open Access Journals (Sweden)

    Sharanabasappa Japatti

    2013-01-01

    Full Text Available This case reports a unique presentation of two different clinical entities amidst few similarities and differences. Usually, aggressive periodontitis and gingival fibromatosis occur independently. Their simultaneous occurrence is rarely found. This report deals with the clinical features and management aspect of such a case.

  7. Electrochemotherapy for the treatment of recurring aponeurotic fibromatosis in a dog.

    Science.gov (United States)

    Spugnini, Enrico P; Di Tosto, Giovanni; Salemme, Scirin; Pecchia, Luca; Fanciulli, Maurizio; Baldi, Alfonso

    2013-06-01

    This paper reports the clinical findings, histopathology, and clinical outcome of a rare case of aponeurotic fibromatosis in a dog. The dog was treated with 4 courses of electrochemotherapy using the drugs cisplatin and bleomycin. There was complete remission and the dog was still disease-free after 18 months.

  8. Hereditary gingival fibromatosis: a report of four cases in the same family.

    Science.gov (United States)

    Avelar, Rafael Linard; de Luna Campos, Gustavo José; de Carvalho Bezerra Falcão, Paulo Germano; da Costa Araújo, Fábio Andrey; de Carvalho, Ricardo Wathson Feitosa; de Souza Andrade, Emanuel Sávio

    2010-02-01

    Hereditary gingival fibromatosis is characterized by a slow, progressive increase in the gingival tissue that develops as either an isolated disorder or as part of the clinical characteristics of diverse syndromes. The present case report describes a Brazilian family with individuals from three generations affected. The proposed treatment was maxillary and mandibular gingivectomy with 12 months of monitoring.

  9. Fibromatosis gingival hereditaria una inusual enfermedad genética: reporte de caso Hereditary gingival fibromatosis a rare genetic disease: case report

    Directory of Open Access Journals (Sweden)

    J Harris Ricardo

    2012-08-01

    Full Text Available Asociada a factores genéticos, que se caracterizada por aumento en el tamaño del tejido gingival, el cual genera dificultades emocionales, estéticas y funcionales. En el presente artículo se reporta un caso de una paciente femenina de 13 años con aumento generalizado en el volumen de la encía, que cubre casi todos los dientes, la historia familiar fue muy importante para el diagnóstico de fibromatosis gingival hereditaria, ya que la madre y un hermano presentaron la misma manifestación.Hereditary gingival fibromatosis is a rare disorder, associated with genetic factors, characterized by various degrees of attached gingival overgrowth, which generates emotional, aesthetic and functional disorders. This article reports the case of a 13-year-old female who presented a generalized severe gingival overgrowth, involving the maxillary and mandibular arches and covering almost the whole dentition. The family history was very important for the diagnosis of hereditary gingival fibromatosis, as the mother and a brother had the same disorder.

  10. Tumor

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008479 Preliminary study of MR elastography in brain tumors. XU Lei(徐磊), et al.Neurosci Imaging Center, Beijing Tiantan Hosp, Capital Med Univ, Beijing 100050.Chin J Radiol 2008;42(6):605-608. Objective To investigate the potential values of magnetic resonance elastography (MRE) for evaluating the brain tumor consistency in vivo. Methods Fourteen patients with known solid brain tumor (5 male, 9 female; age range: 16-63 years)

  11. High frequency of β-catenin heterozygous mutations in extra-abdominal fibromatosis: a potential molecular tool for disease management

    Science.gov (United States)

    Dômont, J; Salas, S; Lacroix, L; Brouste, V; Saulnier, P; Terrier, P; Ranchère, D; Neuville, A; Leroux, A; Guillou, L; Sciot, R; Collin, F; Dufresne, A; Blay, J-Y; Le Cesne, A; Coindre, J-M; Bonvalot, S; Bénard, J

    2010-01-01

    Background: Fibromatosis comprises distinct clinical entities, including sporadic extra-abdominal fibromatosis, which have a high tendency for recurrence, even after adequate resection. There are no known molecular biomarkers of local recurrence. We searched for β-catenin mutations in a European multicentre series of fibromatosis tumours to relate β-catenin mutational status to disease outcome. Methods: Direct sequencing of exon 3 β-catenin gene was performed for 155 frozen fibromatosis tissues from all topographies. Correlation of outcome with mutation rate and type was performed on the extra-abdominal fibromatosis group (101 patients). Results: Mutations of β-catenin were detected in 83% of all cases. Among 101 extra-abdominal fibromatosis, similar mutation rates (87%) were observed, namely T41A (39.5%), S45P (9%), S45F (36.5%), and deletion (2%). None of the clinico-pathological parameters were found to be significantly associated with β-catenin mutational status. With a median follow-up of 62 months, 51 patients relapsed. Five-year recurrence-free survival was significantly worse in β-catenin-mutated tumours regardless of a specific genotype, compared with wild-type tumours (49 vs 75%, respectively, P=0.02). Conclusion: A high frequency (87%) of β-catenin mutation hallmarks extra-abdominal fibromatosis from a large multicentric retrospective study. Moreover, wild-type β-catenin seems to be an interesting prognostic marker that might be useful in the therapeutic management of extra-abdominal fibromatosis. PMID:20197769

  12. Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse

    Directory of Open Access Journals (Sweden)

    Bell Sherilyn

    2007-04-01

    Full Text Available Abstract Background Neoplasia can be driven by mutations resulting in dysregulation of transcription. In the mesenchymal neoplasm, aggressive fibromatosis, subtractive hybridization identified sterile alpha motif domain 9 (SAMD9 as a substantially down regulated gene in neoplasia. SAMD9 was recently found to be mutated in normophosphatemic familial tumoral calcinosis. In this study, we studied the gene structure and function of SAMD9, and its paralogous gene, SAMD9L, and examined these in a variety of species. Results SAMD9 is located on human chromosome 7q21.2 with a paralogous gene sterile alpha motif domain 9 like (SAMD9L in the head-to-tail orientation. Although both genes are present in a variety of species, the orthologue for SAMD9 is lost in the mouse lineage due to a unique genomic rearrangement. Both SAMD9 and SAMD9L are ubiquitously expressed in human tissues. SAMD9 is expressed at a lower level in a variety of neoplasms associated with β-catenin stabilization, such as aggressive fibromatosis, breast, and colon cancers. SAMD9 and SAMD9L contain an amino-terminal SAM domain, but the remainder of the predicted protein structure does not exhibit substantial homology to other known protein motifs. The putative protein product of SAMD9 localizes to the cytoplasm. In vitro data shows that SAMD9 negatively regulates cell proliferation. Over expression of SAMD9 in the colon cancer cell line, SW480, reduces the volume of tumors formed when transplanted into immune-deficient mice. Conclusion SAMD9 and SAMD9L are a novel family of genes, which play a role regulating cell proliferation and suppressing the neoplastic phenotype. This is the first report as far as we know about a human gene that exists in rat, but is lost in mouse, due to a mouse specific rearrangement, resulting in the loss of the SAMD9 gene.

  13. Desmoid-Type Fibromatosis of the Thorax: CT, MRI, and FDG PET Characteristics in a Large Series From a Tertiary Referral Center

    Science.gov (United States)

    Xu, Hai; Koo, Hyun Jung; Lim, Soyeoun; Lee, Jae Wook; Lee, Han Na; Kim, Dong Kwan; Song, Joon Seon; Kim, Mi Young

    2015-01-01

    Abstract The purpose of this study was to describe the radiologic findings of computed tomography (CT), magnetic resonance (MR) imaging, and 18F-fluorodeoxy glucose positron emission tomography (FDG PET) in desmoid-type fibromatosis of the thorax. We retrospectively evaluated 47 consecutive patients with pathologically proven desmoid-type fibromatosis from January 2005 to March 2015. Patients underwent CT (n = 36) and/or MR (n = 32), and 13 patients also underwent FDG PET. Based on CT and MR, the sizes, locations, margins, contours, presence of surrounding fat, extra-compartment extension, bone involvement, and neurovascular involvement of the tumors were recorded. The attenuation, signal intensity, enhancement pattern, and presence of internal low signal band or signal void of the tumors were evaluated. Initial image findings were then compared between 2 groups of tumors: group 1 with recurrence or progression, and group 2 with no recurrence or stable without treatment. Median age at diagnosis of the tumors was 45 years, range 4 to 96, female-to-male ratio 1.8. Median tumor long diameter was 65 mm (range, 22–126 mm). The most common locations were chest wall (42.6%), followed by supraclavicular area, shoulder or axillary area, and mediastinum. The tumors had well-defined margins (83.0%), lobulated in contours (66.0%) surrounding fat (63.8%), extra-compartment extensions (42.6%), bone involvements (42.6%), and neurovascular involvements (27.7%). On CT, tumors had low attenuation (60.0%) with mild enhancement (median 24 HU, range 0–52). On MR, they showed iso-signal intensity (SI) (96.9%) on T1-weighted images (WI), and high SI (90.6%) on T2WI images, with strong (87.5%) and heterogeneous (96.9%) enhancement. Internal low signal bands (84.4%) and signal voids (68.8%) were noted. The median value of maxSUV was 3.1 (range, 2.0–7.3). In group 1 (n = 19, 40.4%), 13 patients suffered recurrence and 6 experienced progression. Group 2 (n = 28, 59

  14. Recycler barrier RF buckets

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, C.M.; /Fermilab

    2011-03-01

    The Recycler Ring at Fermilab uses a barrier rf systems for all of its rf manipulations. In this paper, I will give an overview of historical perspective on barrier rf system, the longitudinal beam dynamics issues, aspects of rf linearization to produce long flat bunches and methods used for emittance measurements of the beam in the RR barrier rf buckets. Current rf manipulation schemes used for antiproton beam stacking and longitudinal momentum mining of the RR beam for the Tevatron collider operation are explained along with their importance in spectacular success of the Tevatron luminosity performance.

  15. Desmoid tumor of bone with enchondromatous nodules, mistaken for chondrosarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Won-Jong [Musculoskeletal Oncology Study Group, Catholic University of Korea (Korea); Department of Orthopaedic Surgery, Uijongbu St. Mary' s Hospital, 65-1 Geumohdong, Uijongbu, Gyunggido, 480-130 (Korea); Kang, Yong-Koo; Lee, An-Hee [Musculoskeletal Oncology Study Group, Catholic University of Korea (Korea); Mirra, Joseph M. [Orthpaedic Oncology, Orthopaedic Hospital, Los Angeles, CA (United States)

    2003-04-01

    Desmoid tumor of bone, also termed desmoplastic fibroma or aggressive fibromatosis, is a rare, locally aggressive fibroblastic tumor. We present a 16-year-old male with a huge desmoid tumor involving the iliac wing. It was associated with enchondromatous nodules mimicking malignancy. The tumor in this patient was mistaken for chondrosarcoma and hemipelvectomy was performed. To our knowledge, such a case has not previously been documented fully in the English literature. The radiographic and pathologic findings and a possible mechanism of enchondromatous nodule formation in fibrous bone tumors are discussed. (orig.)

  16. RF multipole implementation

    CERN Document Server

    Latina, A

    2012-01-01

    The electromagnetic radio-frequency (RF) field of accelerating structures and crab-cavities can exhibit transverse field components due to asymmetries in the azimuthal direction of the element geometry. Tracking simulations must be performed to evaluate the impact of such transverse RF deflections on the beam dynamics. In an ultra-relativistic regime where the Panofsky-Wenzel theorem is applicable, these RF deflections can be modeled via a multipolar expansion of the generating RF field similarly to what is done with static magnetic elements. The element implementing such RF multipolar fields has been called RF multipole. In this note we present an analytical formulation of a thin RF multipole Hamiltonian, and we explicitly calculate the RF kick and the elements of its first- and second- order transfer matrices. Also, we present the implementation of the corresponding code in MAD-X, plus some tests of tracking, simplecticity, consistency, and reflected maps that we successfully applied to verify the correctne...

  17. Idiopathic Gingival Fibromatosis With Aggressive Periodontitis – A Rare Case Report

    Directory of Open Access Journals (Sweden)

    Rizwan M Sanadi

    2010-12-01

    Full Text Available Idiopathic gingival fibromatosis is a rare benign oral condition characterized by a slowly progressive, non-hemorrhagic, fibrous enlargement of maxillary and mandibular attached and non-attached gingivae. A 14 year old female patient suffered from unusual gingival enlargement, more on the left side along with generalized aggressive periodontitis. The enlarged gingiva covered more than two-thirds of the clinical crowns. Marked inflammatory hyperplasia of epithelium and connective tissue of the gingiva was observed histopathologically. Perioscan test was performed, the results of which were negative. The diagnosis of Idiopathic gingival fibromatosis with aggressive periodontitis was made. Conventional periodontal therapy was performed followed by excision of the enlargement using gingivectomy procedure.

  18. Treatment and two-year follow-up of a patient with hereditary gingival fibromatosis

    Directory of Open Access Journals (Sweden)

    Abhinav Bansal

    2011-01-01

    Full Text Available Hereditary gingival fibromatosis is a rare disorder characterized by various degrees of attached gingival overgrowth. Gingival fibromatosis usually develops as an isolated disorder but can be one feature of a syndrome. A case of a 17-year-old female who presented with a generalized severe gingival overgrowth, involving the maxillary and mandibular arches and covering almost the whole dentition. Excess gingival tissue was removed by conventional gingivectomy under local anesthesia. The postoperative course was uneventful and the patient′s appearance improved considerably. Good esthetic result was achieved without recurrence of the gingival overgrowth. After treatment, regular recall visits are necessary in order to evaluate oral hygiene, and the stability of the periodontal treatment.

  19. Management of idiopathic gingival fibromatosis: report of a case and literature review.

    Science.gov (United States)

    Ramnarayan, B K; Sowmya, Krishna; Rema, J

    2011-01-01

    Gingival hyperplasia is a rare condition and is of importance for cosmetic and mechanical reasons. Idiopathic gingival fibromatosis, a benign, slow-growing proliferation of the gingival tissues, is genetically heterogeneous. The enlargement is most intense during the eruption of the primary and permanent teeth, and minimal or nondetectable growth is observed in adults. The genetic aspect, clinical feature, histopathology, immunohistochemistry, and treatment aspects are reviewed. The purpose of this paper was to report a case of idiopathic gingival fibromatosis in a 13-year-old female who had a negative family history for a similar type of gingival enlargement. The diagnosis was established through history, clinical examination, and histopathology using both hematoxylin and eosin and Van Giesen stain (a special stain for collagen). Surgical treatment, which included both gingivectomy and gingivoplasty, was carried out. The case showed remarkable esthetic and functional improvement. The patient returned after a year and showed no recurrence.

  20. Solid tumors of the peritoneum, omentum, and mesentery in children: radiologic-pathologic correlation: from the radiologic pathology archives.

    Science.gov (United States)

    Chung, Ellen M; Biko, David M; Arzamendi, Aaron M; Meldrum, Jaren T; Stocker, J Thomas

    2015-01-01

    Intraperitoneal solid tumors are far less common in children than in adults, and the histologic spectrum of neoplasms of the peritoneum and its specialized folds in young patients differs from that in older patients. Localized masses may be caused by inflammatory myofibroblastic tumor, Castleman disease, mesenteric fibromatosis, or other mesenchymal masses. Inflammatory myofibroblastic tumor is a mesenchymal tumor of borderline biologic potential that appears as a solitary circumscribed mass, possibly with central calcification. Castleman disease is an idiopathic lymphoproliferative disorder that appears as a circumscribed, intensely enhancing mass in the mesentery. Mesenteric fibromatosis, or intra-abdominal desmoid tumor, is a benign tumor of mesenchymal origin associated with familial adenomatous polyposis. Mesenteric fibromatosis appears as a mildly enhancing, circumscribed solitary mass without metastases. Diffuse peritoneal disease may be due to desmoplastic small round cell tumor (DSRCT), non-Hodgkin lymphoma, or rhabdomyosarcoma. DSRCT is a rare member of the small round blue cell tumor family that causes diffuse peritoneal masses without a visible primary tumor. A dominant mass is typically found in the retrovesical space. Burkitt lymphoma is a pediatric tumor that manifests with extensive disease because of its short doubling time. The bowel and adjacent mesentery are commonly involved. Rhabdomyosarcoma may arise as a primary tumor of the omentum or may spread from a primary tumor in the bladder, prostate, or scrotum. Knowledge of this spectrum of disease allows the radiologist to provide an appropriate differential diagnosis and suggest proper patient management.

  1. Management of hereditary gingival fibromatosis: A 2 years follow-up case report

    OpenAIRE

    Amitandra Kumar Tripathi; Gopal Dete; Charanjeet Singh Saimbi; Vivek Kumar

    2015-01-01

    Hereditary gingival fibromatosis (HGF) is a rare hereditary condition characterized by slow, progressive, nonhemorrhagic, fibrous enlargement of gingiva due to increase in sub-mucosal connective tissue component. This paper presents a case report of an 18-year-old female suffering from HGF with positive family history. Her 42-year-old mother also have enlargement of the gums. After through clinical examination of both the patients, routine blood investigation was advised. All the investigatio...

  2. Benign Nerve Sheath Myxoma in an Infant Misdiagnosed as Infantile Digital Fibromatosis.

    Science.gov (United States)

    Güngör, Şule; Şişman, Servet; Kocaturk, Emek; Oguz Topal, Ilteris; Yıldırım, Selda

    2016-07-01

    Herein we present the case of a 16-month boy, clinically diagnosed with infantile digital fibromatosis, but 9 months after continued growth, the mass was excised and the histopathologic diagnosis was that of a benign nerve sheath myxoma. We present this case to emphasize that nerve sheath myxomas (also known as myxoid neurothekeoma) should be included in the differential diagnosis of dermal nodules in infants.

  3. Fibromatosis of the Plantar Fascia: Diagnosis and Indications For Surgical Treatment

    OpenAIRE

    Dürr, Hans R.; Krödel, Andreas; Trouillier, Hans; Lienemann, Andreas; Refior, Hans J.

    1999-01-01

    Plantar fibromatosis is a rare, benign lesion involving the plantar aponeurosis. Eleven patients (13 feet) underwent 24 operations, including local excision, wide excision, or complete plantar fasciectomy. Clinical results were evaluated retrospectively. There were no differences among the subgroups in postoperative complications. Two primary fasciectomies did not recur. Three of six revised fasciectomies, seven of nine wide excisions, and six of seven local excisions recurred. Our results in...

  4. Value of magnetic resonance imaging in the follow-up of fibromatosis. Report on 10 cases

    Energy Technology Data Exchange (ETDEWEB)

    Vanel, D.; Ubaldino, V.; Coffre, C.; Genin, J.; Contesso, G.; Sarrazin, D.

    1989-01-01

    Retrospective study of 10 patients followed for fibromatosis after initial treatment by magnetic resonance imaging. There is a close correlation between an intense signal on weighted T2 images and tumour recurrence. Inversely, a low signal on the weighted T2 image indicated fibrotic sequelae without tumour recurrence. The examination should commence with the weighted T2 sequence. The injection of contrast medium may be an alternative.

  5. Sciatic nerve tumor and tumor-like lesions - uncommon pathologies

    Energy Technology Data Exchange (ETDEWEB)

    Wadhwa, Vibhor; Thakkar, Rashmi S.; Carrino, John A.; Chhabra, Avneesh [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Maragakis, Nicholas; Hoeke, Ahmet; Sumner, Charlotte J.; Lloyd, Thomas E. [Johns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD (United States); Belzberg, Allan J. [Johns Hopkins University School of Medicine, Department of Neurosurgery, Baltimore, MD (United States)

    2012-07-15

    Sciatic nerve mass-like enlargement caused by peripheral nerve sheath tumors or neurocutaneous syndromes such as neurofibromatosis or schwannomatosis has been widely reported. Other causes of enlargement, such as from perineuroma, fibromatosis, neurolymphoma, amyloidosis, endometriosis, intraneural ganglion cyst, Charcot-Marie-Tooth disease, and chronic inflammatory demyelinating polyneuropathy are relatively rare. High-resolution magnetic resonance imaging (MRI) is an excellent non-invasive tool for the evaluation of such lesions. In this article, the authors discuss normal anatomy of the sciatic nerve and MRI findings of the above-mentioned lesions. (orig.)

  6. Idiopathic gingival fibromatosis associated with progressive hearing loss: A nonfamilial variant of Jones syndrome

    Directory of Open Access Journals (Sweden)

    Bagavad Gita

    2014-01-01

    Full Text Available Gingival fibromatosis is characterized by gingival tissue overgrowth of a firm and fibrotic nature. The growth is slow and progressive and is drug-induced, idiopathic, or hereditary in etiology. It occurs isolated or frequently as a component of various syndromes. Our patient presented with the complaint of gingival enlargement associated with progressive deafness, characteristic of Jones syndrome. This case report is important and unique since it is the first known one to have a Jones syndrome-like presentation without a family history. A male patient aged 14 years reported with the chief complaint of swelling of gums and progressive hearing loss in both ears for the past one year. There was no family history or history of drug intake. Enlargement was generalized, fibrotic and bulbous, involving the free and attached gingiva, extending up to the middle 1/3 rd of the crown. Investigations such as pure tone audiogram, impedance audiometry, and Tone decay test concluded that there was severe right and moderate left sensorineural hearing loss. The case was diagnosed to be idiopathic, generalized gingival fibromatosis with progressive hearing loss. The gingival overgrowth was managed by gingivectomy and periodic review. The patient was advised to use high occlusion computer generated hearing aids for his deafness as it was not treatable by medicines or surgery. This unique case report once again emphasizes the heterogeneity of gingival fibromatosis, which can present in an atypical manner.

  7. Extra-abdominal desmoid fibromatosis: A review of management, current guidance and unanswered questions.

    Science.gov (United States)

    Eastley, N; McCulloch, T; Esler, C; Hennig, I; Fairbairn, J; Gronchi, A; Ashford, R

    2016-07-01

    Extra abdominal desmoid fibromatosis is a complex condition with many recognised treatments including active observation, hormonal therapy, chemotherapy, radiotherapy and surgical resection. There is large variation in the natural history of individual desmoid tumours, with some cases progressing aggressively and others regressing spontaneously when observed alone. This combined with an absence of accurate clinical predictors of a desmoid tumour's behaviour has led to difficulties in identifying which patients would benefit most from aggressive treatment, and which could be adequately managed with a policy of active observation alone. This review explores the aetiology and common presentation of extra-abdominal desmoid fibromatosis including the condition's histopathological, clinical and radiological characteristics. The current evidence for potential predictors of desmoid tumour behaviour is also reviewed, along with the indications and evidence for the multitude of treatments available. We also summarise the published guidelines that are currently available for oncologists and surgeons managing extra-abdominal desmoid fibromatosis, and highlight some of the unanswered questions that need to be addressed to optimise the management of this condition. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Juvenile hyaline fibromatosis and infantile systemic hyalinosis: a unifying term and a proposed grading system.

    Science.gov (United States)

    Nofal, Ahmad; Sanad, Mohammad; Assaf, Magda; Nofal, Eman; Nassar, Amani; Almokadem, Sahar; Attwa, Enayat; Elmosalamy, Khaled

    2009-10-01

    It has been suggested that juvenile hyaline fibromatosis and infantile systemic hyalinosis represent different severities of the same disease. We sought to redefine these disorders clearly to establish a common inclusive terminology. The study included two children with early onset of similar pink papulonodular skin lesions and marked gingival hyperplasia. The first case was characterized by flexion contractures of the large joints, fractures, persistent diarrhea, recurrent chest infections, and retarded physical growth. The second patient had large swellings on the scalp and knees without systemic involvement. Radiologic examination revealed fractures and osteolytic bone lesions in the first case, and soft tissue masses in the second case. Laboratory tests showed anemia in both cases, and hypogammaglobulinemia, hypoalbuminemia, and electrolyte imbalance in the first case. Histopathological and ultrastructural evaluation demonstrated hyalinized fibrous tissue in the dermis in both cases. Genetic studies were unavailable. Juvenile hyaline fibromatosis and infantile systemic hyalinosis share many common features that strongly support consideration of these conditions as different expressions of the same disorder. We propose a common term, "hyaline fibromatosis syndrome," which can be divided into mild, moderate, and severe subtypes.

  9. RF feedback for KEKB

    Energy Technology Data Exchange (ETDEWEB)

    Ezura, Eizi; Yoshimoto, Shin-ichi; Akai, Kazunori [National Lab. for High Energy Physics, Tsukuba, Ibaraki (Japan)

    1996-08-01

    This paper describes the present status of the RF feedback development for the KEK B-Factory (KEKB). A preliminary experiment concerning the RF feedback using a parallel comb-filter was performed through a choke-mode cavity and a klystron. The RF feedback has been tested using the beam of the TRISTAN Main Ring, and has proved to be effective in damping the beam instability. (author)

  10. Fibroblastic and myofibroblastic tumors of the head and neck: comprehensive imaging-based review with pathologic correlation.

    Science.gov (United States)

    Hourani, Roula; Taslakian, Bedros; Shabb, Nina S; Nassar, Lara; Hourani, Mukbil H; Moukarbel, Roger; Sabri, Alain; Rizk, Toni

    2015-02-01

    Fibroblastic and myofibroblastic tumors of the head and neck are a heterogeneous group of disorders characterized by the proliferation of fibroblasts, myofibroblasts, or both. These tumors may be further subclassified on the basis of their behavior as benign, intermediate with malignant potential, or malignant. There are different types of fibroblastic and myofibroblastic tumors that can involve the head and neck including desmoid-type fibromatosis, solitary fibrous tumor, myofibroma/myofibromatosis, nodular fasciitis, nasopharyngeal angiofibroma, fibrosarcoma, dermatofibrosarcoma protuberans, fibromatosis coli, inflammatory myofibroblastic tumor, ossifying fibroma, fibrous histiocytoma, nodular fasciitis, fibromyxoma, hyaline fibromatosis and fibrous hamartoma. Although the imaging characteristics of fibroblastic and myofibroblastic tumors of the head and neck are nonspecific, imaging plays a pivotal role in the noninvasive diagnosis and characterization of these tumors, providing information about the constitution of tumors, their extension and invasion of adjacent structures. Correlation with the clinical history may help limit the differential diagnosis and radiologists should be familiar with the imaging appearance of these tumors to reach an accurate diagnosis.

  11. Infantile fibromatosis in childhood: Findings on MR imaging and pathologic correlation

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Joong Mo; Yoon, Hye-Kyung; Suh, Yeon-Lim; Kim, Eung Yeop; Han, Bokyung K.; Yoon, Jung Hwan; Kim, Seung Hoon; Cho Jae Min; Kim, Sung; Moon; Kang, Heung Sik

    2000-01-01

    AIM: The objective of this study was to analyse the MR imaging findings of infantile fibromatosis of childhood and to correlate them with histopathological features. MATERIALS AND METHODS: Seven patients with histologically proven infantile fibromatosis were included in this study. The findings on MR images were retrospectively evaluated and then correlated with the pathological features. Findings on MR imaging evaluated included signal intensity, extent of hyperintense area on T2-weighted images, margins of the lesion, the degree and pattern of enhancement and the presence of fatty tissue. Pathological features evaluated included cellularity, collagenization, and myxoid change. A five point scale was used for the evaluation of the extent of hyperintense area on MR imaging, and each of pathological features. RESULTS: On T1-weighted images, the lesions were iso-intense in two patients; iso- and hypointense in three; and iso-, hypo- and hyperintense in two. On T2-weighted images, iso-, hypo- and hyperintense areas were mixed in all patients, the hyperintense area being the largest portion of the lesion. The margins of the lesions were infiltrative in four patients (57%), smooth in two (29%) and mixed in one (14%). Enhancement was marked in five patients (72%) and diffuse in five (71%). Regardless of the hyperintense signal intensity on T2-weighted images, the grades of each pathologic feature were variable. CONCLUSION: Infantile fibromatosis on MR imaging causes an enhancing mass, that is largely hyperintense on T2-weighted images. Areas of high signal intensity on T2-weighted images corresponded to variable grades of cellularity, collagenization, or myxoid change. Ahn, J.M. (2000)

  12. Variable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis.

    Science.gov (United States)

    Lin, Xu-Yong; Wang, Liang; Zhang, Yong; Dai, Shun-Dong; Wang, En-Hua

    2013-03-26

    Nodular fasciitis is the most common pseudosarcomatous lesion of soft tissue. Ki67 was considered as a useful marker for distinguishing some benign and malignant lesions. To study the usefulness of Ki67 in diagnosis of nodular fasciitis, the expression of Ki67 was examined by using immunostaining in 65 nodular fasciitis specimens, 15 desmoid fibromatosis specimens and 20 fibrosarcoma specimens. The results showed that there was a variable Ki67 index in all 65 cases of nodular fasciitis, and the mean labeling index was 23.71±15.01%. In majority (70.77%) of all cases,the index was ranged from 10% to 50%, in 6.15% (4/65) of cases the higher Ki67 index (over 50%) could be seen. The Ki67 proliferative index was closely related to duration of lesion, but not to age distribution, lesion size, sites of lesions and gender. Moreover, the mean proliferative index in desmoid fibromatosis and fibrosarcoma was 3.20±1.26% and 26.15±3.30% respectively. The mean Ki67 index of nodular fasciitis was not significantly lower than fibrosarcoma, but higher than desmoid fibromatosis. The variable and high Ki67 index in nodular fasciitis may pose a diagnostic challenge. We should not misdiagnose nodular fasciitis as a sarcoma because of its high Ki67 index. The recurrence of nodular fasciitis is rare; and the utility of Ki67 immunostaining may be not suitable for recurrence assessment in nodular fasciitis. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4782335818876666.

  13. Improved pathologic teeth migration following gingivectomy in a case of idiopathic gingival fibromatosis.

    Science.gov (United States)

    Seki, Keisuke; Sato, Shuichi; Asano, Yukhiro; Akutagawa, Hideyasu; Ito, Koichi

    2010-01-01

    A case is reported of a 20-year-old woman with generalized severe gingival overgrowth covering almost all of the teeth with diastemata, diagnosed as idiopathic gingival fibromatosis. After initial therapy, the patient underwent surgery consisting of a full-mouth internal beveled gingivectomy. Postoperatively, the maxillary anterior teeth spontaneously moved to almost optimal positions. Removing the cause by gingivectomy can lead to spontaneous correction of the pathologic tooth migration. With supportive periodontal treatment, the patient showed no recurrence of gingival enlargement or repositioning of the teeth at the 5-year follow-up.

  14. Fibromatosis of the breast: a pictorial review of the imaging and histopathology findings.

    Science.gov (United States)

    Ebrahim, L; Parry, J; Taylor, D B

    2014-10-01

    Fibromatosis of the breast is a rare condition that predominantly affects middle-aged women. It is locally aggressive, and exhibits a high incidence of local recurrence. The clinical presentation and radiological appearance are highly suspicious for carcinoma. Definitive diagnosis is made by diagnostic open biopsy. The aim of this review is to illustrate the main radiological and histopathological characteristics of this rare disease to increase awareness of this entity and discuss the role of magnetic resonance imaging (MRI) in its management. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  15. Fibromatosis colli: findings at high-resolution ultrasound and color Doppler images

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Deok Hee; Shin, Myung Jin; Choi, Hye Young; Choi, Soo Na Mi; Kim, Yong Hwan [University of Ulsan College of Medicine, Asan Medical Center, Ulsan (Korea, Republic of)

    1993-12-15

    Fibromatosis colli is a unique mass of sternocleidomastoid muscle, which usually presents in neonatal period and disappears within one year of age. The diagnosis of this disease is not difficult with the findings of ultrasound and the unique clinical behavior of the mass. The purposes of this study are to evaluate the detailed sonographic features of fibromatosis colli and to find the value of color Doppler studies on the initial examinations and the follow-up of the patients. Twenty-four patients who were diagnosed as fibromatosis colli by the clinical history and ultrasound examination were studied. Among them, 11 patients underwent follow-up studies including color Doppler imaging. We evaluated the size, shape and echogenicity of the mass. The sonographic features and the findings at color Doppler imaging of 11 follow-up studies were compared with those of the initial examinations. Most of the masses were identified at about 3 weeks of age. The mean size of the masses was30x10x15mm. Most of the masses were round (n=13,54%) or fusiform (n=8,33%) in shape. The chogenicity of the mass was iso- (n=15,63%) or slightly hyperechoic (n=9,37%) to that of the surrounding muscles. All 8 cases examined with color Doppler showed branching pattern of arterial signal within the mass at the initial examination. On the follow-up studies, most of the lesions decreased in size and increased in their echogenicity. There was no color Doppler signal on the follow-up study in 7 out of 8 patients in whom both the initial and the follow-up color Doppler imagings were performed. In conclusion, the sonographic findings of fibromatosis coli were more complicated than those described by previous literatures and color Doppler examination could give more information about this disease especially on follow-up studies. A long term follow-up of larger series is required to know the practical significance of the results of follow-up studies

  16. Hereditary Gingival Fibromatosis: A Review and a Report of a Rare Case

    Directory of Open Access Journals (Sweden)

    Hossein Aghili

    2013-01-01

    Full Text Available Hereditary gingival fibromatosis (HGF is a rare condition which manifests itself by an enlarged gingival tissue covering teeth to various extents. The condition may occur isolated or as part of a syndrome. This paper presents a case of 9-year-old female patient suffering from HGF with chief complaint of mouth protrusion. Cephalometric findings showed severe mandibular deficiency and vertical maxillary excess. Patient exhibited perioral muscle contraction on mouth closing. After discussing the treatment possibilities with the patient and her parents, the decision was made to wait until growth potential decreases (following the adolescent growth spurt and to correct the problem with orthognathic surgery.

  17. A Study on the Ultrastructure and Gene Location of Hereditary Gingival Fibromatosis

    Institute of Scientific and Technical Information of China (English)

    杨明华; 张东生; 肖尚喜; 武影; 郑际烈; 孔祥银

    2002-01-01

    Objective To ascertain the histological characteristics of hereditary gingival fibromatosis and the location of HGF gene. Methods A pedigree analysis of HGF was made. The ultrastructure of gingival overgrown tissue was observed by electron microscopy (EMS) and the location of the HGF gene defined with microsatellite markers. Results The HGF consisted of coarse collagen bundles and fibrocytes, epithelial cells, smooth muscle cells, etc. were abnormally arranged; the HGF locus had been mapped to chromosome 5q13-q22. Conclusion The gingival pathological changes resemble "hamartoma" and the findings have implications for identification of the underlying genetic basis of HGF.

  18. Amelogenesis Imperfecta and Generalized Gingival Overgrowth Resembling Hereditary Gingival Fibromatosis in Siblings: A Case Report

    Directory of Open Access Journals (Sweden)

    Emre Yaprak

    2012-01-01

    Full Text Available Amelogenesis imperfecta (AI is a group of hereditary disorders primarily characterized by developmental abnormalities in the quantity and/or quality of enamel. There are some reports suggesting an association between AI and generalized gingival enlargement. This paper describes the clinical findings and oral management of two siblings presenting both AI and hereditary gingival fibromatosis (HGF like generalized gingival enlargements. The treatment of gingival enlargements by periodontal flap surgery was successful in the management of the physiologic gingival form for both patients in the 3-year follow-up period. Prosthetic treatment was also satisfactory for the older patient both aesthetically and functionally.

  19. Hereditary gingival fibromatosis – a case report and management using a novel surgical technique

    OpenAIRE

    K. Butchi Babu; Kalwa Pavankumar; Anuradha, B R; Nupur Arora

    2011-01-01

    Introduction: Hereditary gingival fibromatosis (HGF) is a rare condition presenting varied degrees of gingival enlargement. HGF can present as an isolated entity or as part of a syndrome. Current literatures report a defect in the Son of sevenless-1 gene (SOS-1) on chromosome 2p21-p22 (HGF1) as a possible cause of this condition. Case report: A case of a 16-year-old female is reported who presented generalized extensive gingival overgrowth, involving the maxillary and mandibular arches coveri...

  20. Increased expression of integrin alpha2 and abnormal response to TGF-beta1 in hereditary gingival fibromatosis.

    NARCIS (Netherlands)

    Zhou, J.; Meng, L.; Ye, X.Q.; Hoff, J.W. von den; Bian, Z.

    2009-01-01

    OBJECTIVE: To investigate the possible correlation between integrin alpha1, alpha2, and beta1 expression and excessive collagen synthesis in fibroblasts from 3 unrelated Chinese families with hereditary gingival fibromatosis (HGF). DESIGN: Gingival fibroblasts from three Chinese HGF patients and thr

  1. Susceptibility of Fibromatosis Cells in Short-Term Culture to Ifosfamide: A Possible Experimental Treatment in Clinically Aggressive Cases

    Directory of Open Access Journals (Sweden)

    Mark W. Verrill

    1999-01-01

    Full Text Available Purpose. Deep fibromatoses are large, often rapidly growing but benign soft tissue tumours. Although surgery is the mainstay of treatment, in unremitting and aggressive cases the use of cytotoxic chemotherapy may produce objective tumour responses. Fresh tumour samples from four patients with fibromatosis were investigated as part of a study of drug resistance in soft tissue tumours.

  2. Microfluidic stretchable RF electronics.

    Science.gov (United States)

    Cheng, Shi; Wu, Zhigang

    2010-12-07

    Stretchable electronics is a revolutionary technology that will potentially create a world of radically different electronic devices and systems that open up an entirely new spectrum of possibilities. This article proposes a microfluidic based solution for stretchable radio frequency (RF) electronics, using hybrid integration of active circuits assembled on flex foils and liquid alloy passive structures embedded in elastic substrates, e.g. polydimethylsiloxane (PDMS). This concept was employed to implement a 900 MHz stretchable RF radiation sensor, consisting of a large area elastic antenna and a cluster of conventional rigid components for RF power detection. The integrated radiation sensor except the power supply was fully embedded in a thin elastomeric substrate. Good electrical performance of the standalone stretchable antenna as well as the RF power detection sub-module was verified by experiments. The sensor successfully detected the RF radiation over 5 m distance in the system demonstration. Experiments on two-dimensional (2D) stretching up to 15%, folding and twisting of the demonstrated sensor were also carried out. Despite the integrated device was severely deformed, no failure in RF radiation sensing was observed in the tests. This technique illuminates a promising route of realizing stretchable and foldable large area integrated RF electronics that are of great interest to a variety of applications like wearable computing, health monitoring, medical diagnostics, and curvilinear electronics.

  3. RF gymnastics in synchrotrons

    CERN Document Server

    Garoby, R

    2011-01-01

    The RF systems installed in synchrotrons can be used to change the longitudinal beam characteristics. 'RF gymnastics' designates manipulations of the RF parameters aimed at providing such non-trivial changes. Some keep the number of bunches constant while changing bunch length, energy spread, emittance, or distance between bunches. Others are used to change the number of bunches. After recalling the basics of longitudinal beam dynamics in a hadron synchrotron, this paper deals with the most commonly used gymnastics. Their principle is described as well as their performance and limitations.

  4. RF Gymnastics in Synchrotrons

    CERN Document Server

    Garoby, R

    2005-01-01

    The RF systems installed in synchrotrons can be used to change the longitudinal beam characteristics. "RF gymnastics" designates manipulations of the RF parameters aimed at providing such non-trivial changes. Some keep the number of bunches constant while changing bunch length, energy spread, emittance or distance between bunches. Others are used to change the number of bunches. After recalling the basics of longitudinal beam dynamics in a hadron synchrotron, this paper deals with the most commonly used gymnastics. Their principle is described as well as their performance and limitations.

  5. Geolocation of RF signals

    CERN Document Server

    Progri, Ilir

    2011-01-01

    ""Geolocation of RF Signals - Principles and Simulations"" offers an overview of the best practices and innovative techniques in the art and science of geolocation over the last twenty years. It covers all research and development aspects including theoretical analysis, RF signals, geolocation techniques, key block diagrams, and practical principle simulation examples in the frequency band from 100 MHz to 18 GHz or even 60 GHz. Starting with RF signals, the book progressively examines various signal bands - such as VLF, LF, MF, HF, VHF, UHF, L, S, C, X, Ku, and, K and the corresponding geoloca

  6. Fibromatosis of the cecum presenting with acute appendicitis: a case report

    Directory of Open Access Journals (Sweden)

    Toydemir T

    2011-12-01

    Full Text Available Toygar Toydemir1, Gökhan Ertuğrul21Istanbul Surgery Hospital, Department of General Surgery, Nisantasi-Istanbul, 2Atatürk State Hospital, Department of General Surgery, Düzce, TurkeyAbstract: Although acute appendicitis is a common clinical condition in general surgical practice, <1% of them are associated with malignancies. Appendiceal carcinoids make up most of those malignancies and acute appendicitis cases associated with benign cecal neoplasias are very uncommon. In this study, a 25-year-old female patient who presented with distinct acute appendicitis symptoms is reported. The patient was operated on via open technique. Exploration revealed an appendix with advanced edema and hyperemia. While the cecum was observed to be normal, a solid mass of 2.5 cm diameter was palpated in the appendiceal base. Following the ileocecal resection, histopathological examination revealed the mass as a fibromatosis. The goals of this report are to remind health care professionals that some very rare etiologies may be involved in acute appendicitis diagnosis and treatment, and to underscore the place of laparoscopic approach and preoperative computed tomography in this disease.Keywords: acute appendicitis, fibromatosis, laparoscopy, preoperative computed tomography

  7. Neuromuscular choristoma: characteristic magnetic resonance imaging findings and association with post-biopsy fibromatosis.

    Science.gov (United States)

    Niederhauser, Blake D; Spinner, Robert J; Jentoft, Mark E; Everist, Brian M; Matsumoto, Jane M; Amrami, Kimberly K

    2013-04-01

    To describe imaging characteristics of neuromuscular choristomas (NMC) and to differentiate them from fibrolipomatous hamartomas (FLH). Clinical and imaging characteristics of six patients with biopsy-proven NMC and six patients with FLH were reviewed by musculoskeletal, a pediatric, and two in-training radiologists with a literature review to define typical magnetic resonance imaging features by consensus. Five radiology trainees blinded to cases and naive to the diagnosis of NMC and a musculoskeletal-trained radiologist rated each lesion as having more than or less than 50% intralesional fat, as well as an overall impression using axial T1 images. Sensitivity, specificity, accuracy, and interobserver agreement kappa were determined. Typical features of NMC include smoothly tapering, fusiform enlargement of the sciatic nerve or brachial plexus elements with T1 and T2 signal characteristics closely following those of muscle. Longitudinal bands of intervening low T1 and T2 signal were often present and likely corresponded to fibrous tissue by pathology. Four of five patients with long-term follow-up (80%) developed aggressive fibromatosis after percutaneous or surgical biopsy. Nerve fascicle thickening often resulted in a "coaxial cable" appearance similar to classic FLH, however, using a cutoff of fibromatosis.

  8. Reconfigurable RF Filters Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Space Micro proposes to build upon our existing space microelectronics and hardening technologies and products, to research and develop a novel rad hard/tolerant RF...

  9. Microbunching and RF Compression

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M.; Migliorati, M.; Ronsivalle, C.; Ferrario, M.; Vaccarezza, C.

    2010-05-23

    Velocity bunching (or RF compression) represents a promising technique complementary to magnetic compression to achieve the high peak current required in the linac drivers for FELs. Here we report on recent progress aimed at characterizing the RF compression from the point of view of the microbunching instability. We emphasize the development of a linear theory for the gain function of the instability and its validation against macroparticle simulations that represents a useful tool in the evaluation of the compression schemes for FEL sources.

  10. RF Measurement Concepts

    CERN Document Server

    Caspers, F

    2014-01-01

    For the characterization of components, systems and signals in the radiofrequency (RF) and microwave ranges, several dedicated instruments are in use. In this article the fundamentals of the RF signal techniques are discussed. The key element in these front ends is the Schottky diode which can be used either as a RF mixer or as a single sampler. The spectrum analyser has become an absolutely indispensable tool for RF signal analysis. Here the front end is the RF mixer as the RF section of modern spectrum analyses has a ra ther complex architecture. The reasons for this complexity and certain working principles as well as limitations are discussed. In addition, an overview of the development of scalar and vector signal analysers is given. For the determination of the noise temperature of a one-port and the noise figure of a two-port, basic concepts and relations are shown as well as a brief discussion of commonly used noise-measurement techniques. In a further part of this article the operating principles of n...

  11. Imaging of soft tissue tumors with Tc(V)-99m dimercaptosuccinic acid. A new tumor-seeking agent

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, H.; Endo, K.; Fujita, T.; Nakajima, T.; Sakahara, H.; Torizuka, K.; Shimizu, Y.; Hata, N.; Masuda, H.; Horiuchi, K.

    1984-10-01

    Tumor scintigraphy, using Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS) was performed in 58 patients with soft tissue tumors, and the results were compared with that of Ga-67 citrate. Tc(V)-DMS was found to have a sensitivity of 90% for malignant tumors including aggressive fibromatosis compared to that of Ga-67 citrate, which was 56%. However, the specificity of Tc(V)-DMS for these tumors was 71% but with Ga-67 citrate the specificity was 80%. The imaging accuracy in soft tissue tumors with Tc(V)-DMS and Ga-67 citrate was 78% and 71%, respectively. Although the accumulation of Tc(V)-DMS has been detected in some benign soft tissue tumors, the reduced accumulation in inflammatory lesions compared to Ga-67 citrate was recognized, and Tc(V)-DMS could be of great use in the detection of extension or location of malignant soft tissue tumors.

  12. Hereditary gingival fibromatosis and its management: 2-year follow-up

    Directory of Open Access Journals (Sweden)

    Amitandra Kumar Tripathi

    2014-01-01

    Full Text Available Hereditary gingival fibromatosis (HGF is a rare hereditary condition characterised by slow, progressive, nonhemorrhagic, fibrous enlargement of gingiva caused by increase in sub-mucosal connective tissue component. This paper presents a case report of a 14-year-old male suffering from HGF with positive family history. After through clinical examination, routine blood investigation was advised. All the parameters were within normal physiological limits. Surgical excision of enlarged gingival mass was planned after meticulous scaling and root planning. Patient was recalled 1-week after surgery. Postoperative healing was good and desired crown lengthening was achieved with significant improvement in speech and masticatory problems. There was no recurrence of the disease even after 2 years follow-up.

  13. Management of hereditary gingival fibromatosis: A 2 years follow-up case report

    Science.gov (United States)

    Tripathi, Amitandra Kumar; Dete, Gopal; Saimbi, Charanjeet Singh; Kumar, Vivek

    2015-01-01

    Hereditary gingival fibromatosis (HGF) is a rare hereditary condition characterized by slow, progressive, nonhemorrhagic, fibrous enlargement of gingiva due to increase in sub-mucosal connective tissue component. This paper presents a case report of an 18-year-old female suffering from HGF with positive family history. Her 42-year-old mother also have enlargement of the gums. After through clinical examination of both the patients, routine blood investigation was advised. All the investigations were within normal physiological limits of both the patients. Surgical excision of enlarged gingival tissue was planned after meticulous scaling and root planing. Patients were recalled 1 week after surgery. Postoperative healing were good and desired crown lengthening was achieved with significant improvement in speech and masticatory problems in both the patients. There was no recurrence of the disease even after 2 years follow-up. PMID:26229281

  14. Management of hereditary gingival fibromatosis: A 2 years follow-up case report.

    Science.gov (United States)

    Tripathi, Amitandra Kumar; Dete, Gopal; Saimbi, Charanjeet Singh; Kumar, Vivek

    2015-01-01

    Hereditary gingival fibromatosis (HGF) is a rare hereditary condition characterized by slow, progressive, nonhemorrhagic, fibrous enlargement of gingiva due to increase in sub-mucosal connective tissue component. This paper presents a case report of an 18-year-old female suffering from HGF with positive family history. Her 42-year-old mother also have enlargement of the gums. After through clinical examination of both the patients, routine blood investigation was advised. All the investigations were within normal physiological limits of both the patients. Surgical excision of enlarged gingival tissue was planned after meticulous scaling and root planing. Patients were recalled 1 week after surgery. Postoperative healing were good and desired crown lengthening was achieved with significant improvement in speech and masticatory problems in both the patients. There was no recurrence of the disease even after 2 years follow-up.

  15. Management of hereditary gingival fibromatosis: A 2 years follow-up case report

    Directory of Open Access Journals (Sweden)

    Amitandra Kumar Tripathi

    2015-01-01

    Full Text Available Hereditary gingival fibromatosis (HGF is a rare hereditary condition characterized by slow, progressive, nonhemorrhagic, fibrous enlargement of gingiva due to increase in sub-mucosal connective tissue component. This paper presents a case report of an 18-year-old female suffering from HGF with positive family history. Her 42-year-old mother also have enlargement of the gums. After through clinical examination of both the patients, routine blood investigation was advised. All the investigations were within normal physiological limits of both the patients. Surgical excision of enlarged gingival tissue was planned after meticulous scaling and root planing. Patients were recalled 1 week after surgery. Postoperative healing were good and desired crown lengthening was achieved with significant improvement in speech and masticatory problems in both the patients. There was no recurrence of the disease even after 2 years follow-up.

  16. A rare cervical dystonia mimic in adults: congenital muscular torticollis (fibromatosis colli, a follow-up

    Directory of Open Access Journals (Sweden)

    Mehmet Can Uluer

    2016-02-01

    Full Text Available Neglected or undiagnosed congenital muscular torticollis (CMT in adults is quite rare, although it is the third most common congenital deformity in the newborn [1]. When left untreated at an early age, deficits in lateral and rotational range of motion can occur along with irreversible facial and skeletal deformities that develop over time. Subtle cases can go unnoticed until early adulthood, with predominant fibrotic replacement in the sternocleidomastoid (SCM making physical therapy and chemodenervation mostly ineffective. Surgical intervention, in these cases, can prove effective in alleviating pain, improving function and cosmesis [2].We report an update on a previously reported case, misdiagnosed as cervical dystonia, which had undergone partial myectomy of the anterior belly of the SCM with some relief of symptoms but not total resolution after the correct diagnosis of fibromatosis colli [3].

  17. Basics of RF electronics

    CERN Document Server

    Gallo, A

    2011-01-01

    RF electronics deals with the generation, acquisition and manipulation of high-frequency signals. In particle accelerators signals of this kind are abundant, especially in the RF and beam diagnostics systems. In modern machines the complexity of the electronics assemblies dedicated to RF manipulation, beam diagnostics, and feedbacks is continuously increasing, following the demands for improvement of accelerator performance. However, these systems, and in particular their front-ends and back-ends, still rely on well-established basic hardware components and techniques, while down-converted and acquired signals are digitally processed exploiting the rapidly growing computational capability offered by the available technology. This lecture reviews the operational principles of the basic building blocks used for the treatment of high-frequency signals. Devices such as mixers, phase and amplitude detectors, modulators, filters, switches, directional couplers, oscillators, amplifiers, attenuators, and others are d...

  18. β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast.

    Science.gov (United States)

    Lacroix-Triki, Magali; Geyer, Felipe C; Lambros, Maryou B; Savage, Kay; Ellis, Ian O; Lee, Andrew H S; Reis-Filho, Jorge S

    2010-11-01

    Wnt signalling pathway is known to have a critical role in carcinogenesis and in epithelial-to-mesenchymal transition. Upon Wnt activation, β-catenin is translocated from the membrane to the cytoplasm and nucleus, where it interacts with transcriptional activators. It has been suggested that various spindle cell lesions of the breast may harbour Wnt pathway activation. Given that β-catenin nuclear localization constitutes a good surrogate marker of Wnt canonical pathway activation, we have investigated the distribution of β-catenin in spindle cell lesions of the breast and whether it could be employed in the differential diagnosis of these lesions. A total of 52 metaplastic breast carcinomas, eight fibromatoses and 23 phyllodes tumours were retrieved from our institutions' archives. We performed immunohistochemistry using two anti-β-catenin antibodies. In all, three fibromatoses and 21 metaplastic breast carcinomas were subjected to CTNNB1 (β-catenin encoding gene) mutation analysis by direct gene sequencing. A good correlation between the two antibodies was observed (Spearman's r>0.82, Pfibromatosis, β-catenin was more often diffusely expressed, whereas in metaplastic breast carcinomas, expression was more frequently focal. Membranous β-catenin expression was significantly lower in spindle cell carcinomas than in other subtypes of metaplastic breast carcinomas. In phyllodes tumours, stromal cells of benign and malignant subtypes displayed nuclear β-catenin expression in 94 and 57% of cases, respectively. No CTNNB1 mutation was identified in any of the 21 metaplastic carcinomas analysed, whereas the mutations 45S>S/P and 41T>T/A were found in samples of fibromatosis. In conclusion, β-catenin nuclear expression is a common feature in fibromatoses and in the stromal component of phyllodes tumours, but may also be observed in metaplastic breast carcinomas. β-catenin nuclear expression should not be used as a single marker to differentiate fibromatosis from

  19. ISR RF cavities

    CERN Multimedia

    1983-01-01

    In each ISR ring the radiofrequency cavities were installed in one 9 m long straight section. The RF system of the ISR had the main purpose to stack buckets of particles (most of the time protons)coming from the CPS and also to accelerate the stacked beam. The installed RF power per ring was 18 kW giving a peak accelerating voltage of 20 kV. The system had a very fine regulation feature allowing to lower the voltage down to 75 V in a smooth and well controlled fashion.

  20. Rf2a and rf2b transcription factors

    Science.gov (United States)

    Beachy, Roger N.; Petruccelli, Silvana; Dai, Shunhong

    2007-10-02

    A method of activating the rice tungro bacilliform virus (RTBV) promoter in vivo is disclosed. The RTBV promoter is activated by exposure to at least one protein selected from the group consisting of Rf2a and Rf2b.

  1. AC/RF Superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Ciovati, Gianluigi [JLAB

    2015-02-01

    This contribution provides a brief introduction to AC/RF superconductivity, with an emphasis on application to accelerators. The topics covered include the surface impedance of normal conductors and superconductors, the residual resistance, the field dependence of the surface resistance, and the superheating field.

  2. Remote RF Battery Charging

    NARCIS (Netherlands)

    Visser, H.J.; Pop, V.; Op het Veld, J.H.G.; Vullers, R.J.M.

    2011-01-01

    The design of a remote RF battery charger is discussed through the analysis and design of the subsystems of a rectenna (rectifying antenna): antenna, rectifying circuit and loaded DC-to-DC voltage (buck-boost) converter. Optimum system power generation performance is obtained by adopting a system in

  3. Reliability engineering in RF CMOS

    OpenAIRE

    2008-01-01

    In this thesis new developments are presented for reliability engineering in RF CMOS. Given the increase in use of CMOS technology in applications for mobile communication, also the reliability of CMOS for such applications becomes increasingly important. When applied in these applications, CMOS is typically referred to as RF CMOS, where RF stands for radio frequencies.

  4. Aggressive Fibromatosis: Imaging Diagnosis and Clinical Therapy%侵袭性纤维瘤病的影像诊断及临床治疗分析

    Institute of Scientific and Technical Information of China (English)

    郑德春; 陈韵彬; 陈英; 曹喜生; 张和军

    2012-01-01

    with mild or not enhancement. Most lesions were ovoid or infiltrative with clear outline and with an irregular or lobulated contour. Other 10 CT imaging showed heterogenous iso-hypodense on plain CT scan. Most lesions showed inhomogeneous mild enhancement after contrast inject, while some could enhanced intensely, especial on the delay scan. Routine pathobiology feature of AF was composed of fibroblasts, fibrocytes and bundles of collagen fiber. Immunohistochemical staining showed that Vim, Bcl-2, CD99, SMA, CD34 et cetera were positive. Among 29 resection cases, 25 cases were of no obvious residues£2 with pathological approved residual diseases and 2 fail to excision of tumor, 8 cases of them underwent supplement radiotherapy after resection. Conclusion aggressive fibromatosis has characteristic on MRI and CT examination. It is a general agreement that radical surgery followed by radiotherapy or Pharmaceuticals for primary and recurrence aggressive fibromatosis

  5. Do Liposomal Apoptotic Enhancers Increase Tumor Coagulation and End-Point Survival in Percutaneous Radiofrequency Ablation of Tumors in a Rat Tumor Model? 1

    Science.gov (United States)

    Yang, Wei; Elian, Mostafa; Hady, El-Shymma A.; Levchenko, Tatyana S.; Sawant, Rupa R.; Signoretti, Sabina; Collins, Michael; Torchilin, Vladimir P.; Goldberg, S. Nahum

    2010-01-01

    Purpose: To characterize effects of combining radiofrequency (RF) ablation with proapoptotic intravenous liposome-encapsulated paclitaxel and doxorubicin on tumor destruction, apoptosis and heat-shock protein (HSP) production, intratumoral drug accumulation, and end-point survival. Materials and Methods: R3230 mammary adenocarcinomas (n = 177) were implanted in 174 rats in this animal care committee–approved study. Tumors received (a) no treatment, (b) RF ablation, (c) paclitaxel, (d) RF ablation followed by paclitaxel (RF ablation–paclitaxel), (e) paclitaxel before RF ablation (paclitaxel–RF ablation), (f) RF ablation followed by doxorubicin (RF ablation–doxorubicin), (g) paclitaxel followed by doxorubicin without RF ablation (paclitaxel-doxorubicin), or (h) paclitaxel before RF ablation, followed by doxorubicin (paclitaxel–RF ablation–doxorubicin). Tumor coagulation area and diameter were compared at 24–96 hours after treatment. Intratumoral paclitaxel uptake with and without RF ablation were compared. Immunohistochemical staining revealed cleaved caspase-3 and 70-kDa HSP (HSP70) expression. Tumors were randomized into eight treatment arms for Kaplan-Meier analysis of defined survival end-point (3.0-cm diameter). Results: Paclitaxel–RF ablation increased tumor coagulation over RF ablation or paclitaxel (mean, 14.0 mm ± 0.9 [standard deviation], 6.7 mm ± 0.6, 2.5 mm ± 0.6, respectively; P RF ablation–doxorubicin had similar tumor coagulation (P RF ablation, at 24 and 96 hours. Mean intratumoral paclitaxel accumulation for paclitaxel–RF ablation (6.76 μg/g ± 0.35) and RF ablation–paclitaxel (9.28 μg/g ± 0.87) increased over that for paclitaxel (0.63 μg/g ± 0.25, P RF ablation–doxorubicin (56.8 days ± 25.3) was greater, compared with that for paclitaxel–RF ablation or RF ablation–paclitaxel (17.6 days ± 2.5), RF ablation–doxorubicin (30.3 days ± 4.9, P cellular apoptosis and HSP production effectively increases RF ablation

  6. rf SQUID metamaterials

    OpenAIRE

    Lazarides, N.; Tsironis, G. P.

    2007-01-01

    An rf superconducting quantum interference device (SQUID) array in an alternating magnetic field is investigated with respect to its effective magnetic permeability, within the effective medium approximation. This system acts as an inherently nonlinear magnetic metamaterial, leading to negative magnetic response, and thus negative permeability, above the resonance frequency of the individual SQUIDs. Moreover, the permeability exhibits oscillatory behavior at low field intensities, allowing it...

  7. RF Power Amplifier Analysis

    Directory of Open Access Journals (Sweden)

    M. Lokay

    1993-04-01

    Full Text Available The special program is presented for the demonstration of RF power transistor amplifiers for the purposes of the high-school education in courses of radio transmitters. The program is written in Turbo Pascal 6. 0 and enables to study the waveforms in selected points of the amplifier and to draw the trajectories of the working point in a plot of output transistor characteristics.

  8. Microwave and RF engineering

    CERN Document Server

    Sorrentino, Roberto

    2010-01-01

    An essential text for both students and professionals, combining detailed theory with clear practical guidance This outstanding book explores a large spectrum of topics within microwave and radio frequency (RF) engineering, encompassing electromagnetic theory, microwave circuits and components. It provides thorough descriptions of the most common microwave test instruments and advises on semiconductor device modelling. With examples taken from the authors' own experience, this book also covers:network and signal theory;electronic technology with guided electromagnetic pr

  9. RF Pulsed Heating

    Energy Technology Data Exchange (ETDEWEB)

    Pritzkau, David P.

    2002-01-03

    RF pulsed heating is a process by which a metal is heated from magnetic fields on its surface due to high-power pulsed RF. When the thermal stresses induced are larger than the elastic limit, microcracks and surface roughening will occur due to cyclic fatigue. Pulsed heating limits the maximum magnetic field on the surface and through it the maximum achievable accelerating gradient in a normal conducting accelerator structure. An experiment using circularly cylindrical cavities operating in the TE{sub 011} mode at a resonant frequency of 11.424 GHz is designed to study pulsed heating on OFE copper, a material commonly used in normal conducting accelerator structures. The high-power pulsed RF is supplied by an X-band klystron capable of outputting 50 MW, 1.5 {micro}s pulses. The test pieces of the cavity are designed to be removable to allow testing of different materials with different surface preparations. A diagnostic tool is developed to measure the temperature rise in the cavity utilizing the dynamic Q change of the resonant mode due to heating. The diagnostic consists of simultaneously exciting a TE{sub 012} mode to steady-state in the cavity at 18 GHz and measuring the change in reflected power as the cavity is heated from high-power pulsed RF. Two experimental runs were completed. One run was executed at a calculated temperature rise of 120 K for 56 x 10{sup 6} pulses. The second run was executed at a calculated temperature rise of 82 K for 86 x 10{sup 6} pulses. Scanning electron microscope pictures show extensive damage occurring in the region of maximum temperature rise on the surface of the test pieces.

  10. RF Based Spy

    Directory of Open Access Journals (Sweden)

    Robot Prerna Jain

    2014-04-01

    Full Text Available The intention of this paper is to reduce human victims in terrorist attack such as 26/11. So this problem can be overcome by designing the RF based spy robot which involves wireless camera. so that from this we can examine rivals when it required. This robot can quietly enter into enemy area and sends us the information via wireless camera. On the other hand one more feature is added in this robot that is colour sensor. Colour sensor senses the colour of surface and according to that robot will change its colour. Because of this feature this robot can’t easily detected by enemies. The movement of this robot is wirelessly controlled by a hand held RF transmitter to send commands to the RF receiver mounted on the moving robot. Since human life is always Valueable, these robots are the substitution of soldiers in war areas. This spy robot can also be used in star hotels, shopping malls, jewelry show rooms, etc where there can be threat from intruders or terrorists.

  11. Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy

    Directory of Open Access Journals (Sweden)

    H. Thomas Temple

    2011-08-01

    Full Text Available Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11–70, and the mean tumor size was 11.5 cm (range 2.5–21.2 cm. The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1–149 months. Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects.

  12. Treatment of Extra — Abdominal Desmoid Tumors with Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, Corey [Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72211 (United States); Emory, Cynthia [Wake Forest School of Medicine, Medical Center Blvds, Winston-Salem, NC 27157 (United States); Adams, Sheila [Department of Orthopaedics and Rehabilitation, University of Miami Miller School of Medicine, Cedars Medical Center, 1400 NW 12th Avenue (R-12), Miami, FL 33136 (United States); Cohen, Jonathan [Division of Psychology, University of Miami Miller School of Medicine, 1695 N.W. 9th Ave. (D-29), Miami, FL 33136 (United States); Pitcher, John David [Department of Orthopaedics and Rehabilitation, University of Miami School of Medicine, 1400 NW 12th Avenue (R-12), Miami, FL 33136 (United States); Potter, Benjamin Kyle [Department of Orthopaedic Surgery, Walter Reed Army Medical Center, 6900 Georgia Avenue North West, Washington, D.C., 20307 (United States); Temple, H. Thomas [Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, 1600 N.W. 10th Avenue (R-12), Miami, FL 33136 (United States)

    2011-08-25

    Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males) with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11–70), and the mean tumor size was 11.5 cm (range 2.5–21.2 cm). The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1–149 months). Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia) occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects.

  13. MR Histoanatomical Distribution of 290 Soft-tissue Tumors

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Tae Yong; Lee, In Sook; Lee, Gee Won; Kim, Jeung Il; Choi, Kyung Un; Kim, Won Taek [Pusan National University Hospital, Busan (Korea, Republic of)

    2008-12-15

    This study was designed too identify the MR histoanatomical distribution of soft-tissue tumors. A total of 290 soft-tissue tumors of 281 patients were analyzed by the use of MR imaging and were pathologically confirmed after surgical resection or a biopsy. There were 120 malignant soft-tissue tumors including tumors of an intermediate malignancy and 170 benign tumors. The histoanatomical locations were divided into three types: 'type I' with superficial layer tumors that involved the cutaneous and subcutaneous tissue, 'type II' with deep layer tumors that involved the muscle or tendon and 'type III' with soft tissue tumors that involved both the superficial and deep layers. Soft-tissue tumors with more than three cases with a frequency of more than 75% included dermatofibrosarcoma protuberans, glomus tumor, angiolipoma, leiomyosarcoma and lymphoma as 'type I' tumors. 'Type II' tumors with more than three cases with a frequency of more than 75% included liposarcoma, fibromatosis, papillary endothelial hyperplasia and rhabdomyosarcoma. 'Type III' tumors with more than three cases with a frequency of more than 50% included neurofibromatosis. The MR histoanatomical distributions of soft tissue tumors are useful in the differential pathological diagnosis when a soft-tissue tumor has a nonspecific MR appearance.

  14. Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous.

    Science.gov (United States)

    Takano, Elena A; Hunter, Sally M; Campbell, Ian G; Fox, Stephen B

    2015-05-01

    Low-grade fibromatosis-like spindle cell carcinomas are very rare breast carcinomas comprising <0.5% of all breast cancers. They demonstrate immunohistochemical (IHC) features of basal-like/metaplastic breast carcinomas, but the underlying molecular characteristics are unknown. We hypothesised that, as with IHC similarities, there may be common genomic alterations between spindle cell and basal-like/metaplastic carcinomas. Genomic mutational profile and genomic copy number aberration (CNA) analyses were performed on three cases of this unusual entity, and findings were compared with that reported for basal-like/metaplastic breast carcinomas. Copy number analyses by molecular inversion probe assays of the three spindle cell carcinoma samples revealed little overall genomic CNAs with only minor changes identified (fraction of the genome altered; 1.3%-6.4%), but with a common 9p21.3 loss in 2 out of 3 samples, with CDKN2A (p16) being a likely candidate. No areas of commonality were identified in an in silico analysis compared with publically available basal-like/metaplastic carcinoma copy number data. These tumours are characterised by low genomic instability, and share no CNAs with other metaplastic carcinomas. These findings favour this entity being a unique group genotype and belie their apparent homogeneous morphology and phenotype. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  15. Hereditary gingival fibromatosis: A report of two cases in the same family

    Directory of Open Access Journals (Sweden)

    Vanali V Umrania

    2016-01-01

    Full Text Available Overgrowth of keratinized gingival tissues is a common condition and is described under variety of names. Causes of such enlargement can be medications, hereditary, and/or local irritating factors. Mutation in SOS1, son-of-sevenless gene, is thought to be responsible for hereditary gingival fibromatosis. This report shows a case of 19-year-old male and his 15-year-old sister, with a chief complaint of overgrowth of gingival and irregularly placed teeth. A similar overgrowth was also found in other members of the same family, without any drug history or syndromic conditions. An occurrence of the disease has been found in two generations of this family and therefore, it may be following autosomal dominant trait of inheritance. Since it is idiopathic and has a genetic cause for its occurrence, it cannot be prevented. Both cases underwent a surgical intervention to rectify the abnormality and were followed from 6 months to 1 year, during which there was no recurrence.

  16. RF power generation

    CERN Document Server

    Carter, R G

    2011-01-01

    This paper reviews the main types of r.f. power amplifiers which are, or may be, used for particle accelerators. It covers solid-state devices, tetrodes, inductive output tubes, klystrons, magnetrons, and gyrotrons with power outputs greater than 10 kW c.w. or 100 kW pulsed at frequencies from 50 MHz to 30 GHz. Factors affecting the satisfactory operation of amplifiers include cooling, matching and protection circuits are discussed. The paper concludes with a summary of the state of the art for the different technologies.

  17. Other RF power sources

    Energy Technology Data Exchange (ETDEWEB)

    Kurkin, G.Ya. [Budker Inst. of Nuclear Physics, Novosibirsk (Russian Federation)

    1999-09-01

    The main subjects discussed in this paper are as follows. Triode tube; main characteristics of the equivalent schematic of the amplifying stage. Requirements for operation of a triode stage loaded with an accelerating cavity. Influence of parameters of the output stage and transmission line length on the output impedance of RF system for the beam. Typical design of the power output stage. Magnetron, travelling-wave tube, principles of operation, main parameters. Magnetron loaded with a microtron cavity, methods of coupling, requirements for stable operation. Magnicon - BHF generator with a circular deflection of the electron beam, principle of operation, results of development. (author)

  18. SPS RF cavity

    CERN Multimedia

    1974-01-01

    The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. A power of up to 790 kW can be supplied to each giving a total accelerating voltage of about 8 MV. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities.

  19. Fibromatosis gingival. Diagnóstico y tratamiento: Reporte de un caso Ceccarelli-Calle JF, Ricaldi-Camahualí J, Berastain-Arenas JF. Fibromatosis gingival. Diagnóstico

    OpenAIRE

    Ceccarelli Calle, Juan Francisco; Residente en Periodoncia e Implantes Dentales. Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima; Ricaldi Camahualí, Jennifer Nadia; Residente en Odontogía Pediátrica. Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima,; Berastain Arenas, Juan Francisco; Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima

    2014-01-01

    La fibromatosis gingival es una deformidad desarrollada de baja prevalencia. Las características clínicas de la FG incluyen tejidos gingivales hiperplásicos de consistencia firme y nodular,presentándose en forma generalizada o localizada. Las características histológicas de la FG incluyen principalmente tejido conectivo con un denso infiltrado rico en fibras de colágeno y un epitelio denso con papilas epiteliales largas Se presenta un reporte de caso de un paciente masculino de 12 años referi...

  20. Fibromatosis gingival. Diagnóstico y tratamiento: Reporte de un caso Ceccarelli-Calle JF, Ricaldi-Camahualí J, Berastain-Arenas JF. Fibromatosis gingival. Diagnóstico

    OpenAIRE

    Ceccarelli Calle, Juan Francisco; Residente en Periodoncia e Implantes Dentales. Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima; Ricaldi Camahualí, Jennifer Nadia; Residente en Odontogía Pediátrica. Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima,; Berastain Arenas, Juan Francisco; Facultad de Estomatología. Universidad Peruana Cayetano Heredia. Lima

    2014-01-01

    La fibromatosis gingival es una deformidad desarrollada de baja prevalencia. Las características clínicas de la FG incluyen tejidos gingivales hiperplásicos de consistencia firme y nodular,presentándose en forma generalizada o localizada. Las características histológicas de la FG incluyen principalmente tejido conectivo con un denso infiltrado rico en fibras de colágeno y un epitelio denso con papilas epiteliales largas Se presenta un reporte de caso de un paciente masculino de 12 años referi...

  1. RF Characterization of Superconducting Samples

    CERN Document Server

    Junginger, T; Welsch, C

    2009-01-01

    At CERN a compact Quadrupole Resonator has been re-commissioned for the RF characterization of superconducting materials at 400 MHz. In addition the resonator can also be excited at multiple integers of this frequency. Besides Rs it enables determination of the maximum RF magnetic field, the thermal conductivity and the penetration depth of the attached samples, at different temperatures. The features of the resonator will be compared with those of similar RF devices and first results will be presented.

  2. LANSCE RF System Refurbishment

    CERN Document Server

    Rees, Daniel; Kwon, Sung-il; Lyles, John T M; Lynch, Michael; Prokop, Mark; Reass, William; Tallerico, Paul J

    2005-01-01

    The Los Alamos Neutron Science Center (LANSCE) is in the planning phase of a refurbishment project that will sustain reliable facility operations well into the next decade. The LANSCE accelerator was constructed in the late 1960s and early 1970s and is a national user facility that provides pulsed protons and spallation neutrons for defense and civilian research and applications. We will be replacing all the 201 MHz RF systems and a substantial fraction of the 805 MHz RF systems and high voltage systems. The current 44 LANSCE 805 MHz, 1.25 MW klystrons have an average in-service time in excess of 110,000 hours. All 44 must be in service to operate the accelerator. There are only 9 spares left. The klystrons receive their DC power from the power system originally installed in 1960. Although this power system has been extremely reliable, gas analysis of the insulating oil is indicating age related degradation that will need attention in the next few years. This paper will provide the design details of the new R...

  3. SPS RF Accelerating Cavity

    CERN Multimedia

    1979-01-01

    This picture shows one of the 2 new cavities installed in 1978-1979. The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also increased: to the first 2 MW plant a second 2 MW plant was added and by end 1979 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412016X, 7412017X, 7411048X

  4. SPS RF Cavity

    CERN Multimedia

    1975-01-01

    The picture shows one of the two initially installed cavities. The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also gradually increased: by end 1980 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412017X, 7411048X, 7505074.

  5. Diagnosis and management of nonsyndromic hereditary gingival fibromatosis in a 13 year old girl: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Lata Goyal

    2012-01-01

    Full Text Available Hereditary gingival fibromatosis is a rare condition characterized by various degree of gingival overgrowth. It usually develops as an isolated disorder but can manifest with multisystem syndrome. We are here presenting a case of a 13-year-old girl who presented with severe enlargement of gingiva covering all most the entire crown involving both maxillary and mandibular arches. Differential diagnosis includes drug-induced and idiopathic gingival enlargement. Excess gingival tissue was removed by full mouth gingivectomy and sent for histopathological examination. Postoperative course was uneventful and patient′s esthetics improved significantly. A 12 month postoperative period shows no recurrence.

  6. [Pulmonary Metastasis from a Phyllodes Tumor of the Breast Developing Sixteen Years after Initial Surgery].

    Science.gov (United States)

    Chang, Sung-Soo; Nakano, Takayuki; Okamoto, Taku; Takabatake, Daisuke

    2015-11-01

    We report a case of solitary pulmonary metastasis from a phyllodes tumor of the breast appearing 16 years after initial surgery. The patient was a 56-year-old woman who had undergone surgical extirpation of a left breast tumor diagnosed as phyllodes tumor (borderline malignancy) in 1998, and a right breast tumor diagnosed as fibromatosis in 2000. Sixteen years after the initial operation, she consulted our hospital because of a chest X-ray abnormality detected at a screening examination. Chest computed tomography revealed a well defined nodular shadow in the left upper lobe of the lung. Surgery was done since primary lung cancer was suspected. However, pathological diagnosis was a pulmonary metastasis from the phyllodes tumor of the left breast. Right breast tumor was also diagnosed as a metastasis from the left breast tumor by histopathological re-evaluation.

  7. Giant Desmoid Tumor of the Anterior Abdominal Wall in a Young Female: A Case Report

    Directory of Open Access Journals (Sweden)

    Mahim Koshariya

    2013-01-01

    Full Text Available Desmoid tumors (also called desmoids fibromatosis are rare slow growing benign and musculoaponeurotic tumors. Although these tumors have a propensity to invade surrounding tissues, they are not malignant. These tumors are associated with women of fertile age, especially during and after pregnancy. We report a young female patient with a giant desmoid tumor of the anterior abdominal wall who underwent primary resection. The patient had no history of an earlier abdominal surgery. Preoperative evaluation included abdominal ultrasound, computed tomography, and magnetic resonance imaging. The histology revealed a desmoid tumor. Primary surgical resection with immediate reconstruction of abdominal defect is the best management of this rarity. To the best of our knowledge and PubMed search, this is the first case ever reported in the medical literature of such a giant desmoid tumor arising from anterior abdominal wall weighing 6.5 kg treated surgically with successful outcome.

  8. Soft tissue tumors following traumatic injury: two observations of interest for the medicolegal causality.

    Science.gov (United States)

    Delpla, P A; Rouge, D; Durroux, R; Rouquette, I; Arbus, L

    1998-06-01

    Two cases of tumors of the soft tissues developing at the site of a previous traumatic injury occurring a few years earlier are reported. One was finally diagnosed as aggressive fibromatosis and the other as low-grade fibrosarcoma. Among the pathogenic mechanisms and the etiologic factors involved in such tumors, the posttraumatic causality is discussed, and in addition to the initial trauma, the role of iterative surgery in the first case and mineral muscular inclusions in the second case are examined. The different therapeutic approaches of such lesions are also reviewed.

  9. NSLS-II RF SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    Rose, J.; Gash, W.; Holub, B.; Kawashima, Y.; Ma, H.; Towne, N.; Yeddulla, M.

    2011-03-28

    The NSLS-II is a new third generation light source being constructed at Brookhaven Lab. The storage ring is optimized for low emittance by use of damping wigglers to reduce the emittance to below 1 nm-rad. The RF systems are designed to provide stable beam through tight RF phase and amplitude stability requirements.

  10. RF MEMS Based Reconfigurable Antennas

    Science.gov (United States)

    Simons, Rainee N.

    2004-01-01

    The presentation will first of all address the advantages of RF MEMS circuit in antenna applications and also the need for electronically reconfigurable antennas. Next, discuss some of the recent examples of RF MEMS based reconfigurable microstrip antennas. Finally, conclude the talk with a summary of MEMS antenna performance.

  11. Desmoid-type fibromatosis of the head and neck region in the paediatric population: a clinicopathological and genetic study of seven cases

    NARCIS (Netherlands)

    Flucke, U.E.; Tops, B.B.J.; Diest, P.J. van; Slootweg, P.J.

    2014-01-01

    AIMS: Desmoid-type fibromatosis (desmoid) is a locally aggressive (myo)fibroblastic lesion. It represents one of the more common fibrous tumours in children and adolescents. The head and neck region is more often involved than in adults. METHODS AND RESULTS: We investigated the clinicopathological a

  12. Desmoid-type fibromatosis of the head and neck region in the paediatric population: a clinicopathological and genetic study of seven cases

    NARCIS (Netherlands)

    Flucke, U.E.; Tops, B.B.J.; Diest, P.J. van; Slootweg, P.J.

    2014-01-01

    AIMS: Desmoid-type fibromatosis (desmoid) is a locally aggressive (myo)fibroblastic lesion. It represents one of the more common fibrous tumours in children and adolescents. The head and neck region is more often involved than in adults. METHODS AND RESULTS: We investigated the clinicopathological a

  13. Enhanced responsivity resonant RF photodetectors.

    Science.gov (United States)

    Liu, R; Dev, S; Zhong, Y; Lu, R; Streyer, W; Allen, J W; Allen, M S; Wenner, B R; Gong, S; Wasserman, D

    2016-11-14

    The responsivity of room-temperature, semiconductor-based photodetectors consisting of resonant RF circuits coupled to microstrip buslines is investigated. The dependence of the photodetector response on the semiconductor material and RF circuit geometry is presented, as is the detector response as a function of the spatial position of the incident light. We demonstrate significant improvement in detector response by choice of photoconductive material, and for a given material, by positioning our optical signal to overlap with positions of RF field enhancement. Design of RF circuits with strong field enhancement are demonstrated to further improve detector response. The improved detector response demonstrated offers opportunities for applications in RF photonics, materials metrology, or single read-out multiplexed detector arrays.

  14. Modeling rf breakdown arcs

    CERN Document Server

    Insepov, Zeke; Huang, Dazhang; Mahalingam, Sudhakar; Veitzer, Seth

    2010-01-01

    We describe breakdown in 805 MHz rf accelerator cavities in terms of a number of mechanisms. We devide the breakdown process into three stages: (1) we model surface failure using molecular dynamics of fracture caused by electrostatic tensile stress, (2) we model the ionization of neutrals responsible for plasma initiation and plasma growth using a particle in cell code, and (3) we model surface damage by assuming a process similar to unipolar arcing. Although unipolar arcs are strictly defined with equipotential boundaries, we find that the cold, dense plasma in contact with the surface produces very small Debye lengths and very high electric fields over a large area. These high fields produce strong erosion mechanisms, primarily self sputtering, compatible with the crater formation that we see. Results from the plasma simulation are included as a guide to experimental verification of this model.

  15. Radiofrequency ablation of pulmonary tumors

    Energy Technology Data Exchange (ETDEWEB)

    Crocetti, Laura, E-mail: l.crocetti@med.unipi.i [Division of Diagnostic Imaging and Intervention, Department of Liver Transplants, Hepatology and Infectious Diseases, Pisa University School of Medicine (Italy); Lencioni, Riccardo [Division of Diagnostic Imaging and Intervention, Department of Liver Transplants, Hepatology and Infectious Diseases, Pisa University School of Medicine (Italy)

    2010-07-15

    The development of image-guided percutaneous techniques for local tumor ablation has been one of the major advances in the treatment of solid tumors. Among these methods, radiofrequency (RF) ablation is currently established as the primary ablative modality at most institutions. RF ablation is accepted as the best therapeutic choice for patients with early-stage hepatocellular carcinoma when liver transplantation or surgical resection are not suitable options and is considered as a viable alternate to surgery for inoperable patients with limited hepatic metastatic disease, especially from colorectal cancer. Recently, RF ablation has been demonstrated to be a safe and valuable treatment option for patients with unresectable or medically inoperable lung malignancies. Resection should remain the standard therapy for non-small cell lung cancer (NSCLC) but RF ablation may be better than conventional external-beam radiation for the treatment of the high-risk individual with NSCLC. Initial favourable outcomes encourage combining radiotherapy and RF ablation, especially for treating larger tumors. In the setting of colorectal cancer lung metastases, survival rates provided by RF ablation in selected patients, are substantially higher than those obtained with any chemotherapy regimens and provide indirect evidence that RF ablation therapy improves survival in patients with limited lung metastatic disease.

  16. Management of traumatic dental injury after periodontal surgery in patient with hereditary gingival fibromatosis: case report.

    Science.gov (United States)

    Inagaki, Koji; Kamei, Hidehiko; Mitani, Akio; Noguchi, Toshihide

    2014-06-01

    Traumatic Dental Injury (TDI) is often caused by a bruise from a sports-related incident or fall. In individuals with maxillary protrusion, the risk for TDI may be higher. We treated a patient with Hereditary Gingival Fibromatosis (HGF), a rare genetic disorder characterized by proliferative fibrous overgrowth of gingival tissue, who subsequently received a TDI after periodontal surgery. A 13-year-old Japanese boy was referred to the Division of Periodontics at Aichi Gakuin University Dental Hospital in March 2005 with the chief complaint of generalized severe gingival overgrowth involving the maxillary and mandibular arches covering nearly all teeth. Prior to orthodontic treatment, periodontal surgery was performed under general anesthesia in consideration of mastication, dental esthetics, and development. However, soon thereafter in August 2007, the protruded maxillary anterior teeth received an injury while he was playing basketball and the maxillary central incisors showed extrusive luxation. Two weeks after being reset, the maxillary anterior teeth were splinted with wire and adhesive resin cement, and then the splint was removed following evaluations of clinical and radiographic showing signs of normal periodontium. The marginal bone height corresponded to that seen in radiographic findings after the reset and orthodontic treatment was started 1 year later. At the 6-year follow-up examination, the teeth remained asymptomatic, pulpal response to sensitivity tests was normal, and healing was shown in radiographic images. In the present HGF case, we speculated that removal of thick gingiva around the teeth, which might have functioned as a mouth guard, increased the risk for TDI while playing sports. TDI is more likely to occur in patients with exposed protruded misaligned teeth after periodontal surgery. Therefore, it is important for HGF patients with such protruded maxillary anterior teeth to use a mouth guard when participating in sports following

  17. A Micromechanical RF Channelizer

    Science.gov (United States)

    Akgul, Mehmet

    The power consumption of a radio generally goes as the number and strength of the RF signals it must process. In particular, a radio receiver would consume much less power if the signal presented to its electronics contained only the desired signal in a tiny percent bandwidth frequency channel, rather than the typical mix of signals containing unwanted energy outside the desired channel. Unfortunately, a lack of filters capable of selecting single channel bandwidths at RF forces the front-ends of contemporary receivers to accept unwanted signals, and thus, to operate with sub-optimal efficiency. This dissertation focuses on the degree to which capacitive-gap transduced micromechanical resonators can achieve the aforementioned RF channel-selecting filters. It aims to first show theoretically that with appropriate scaling capacitive-gap transducers are strong enough to meet the needed coupling requirements; and second, to fully detail an architecture and design procedure needed to realize said filters. Finally, this dissertation provides an actual experimentally demonstrated RF channel-select filter designed using the developed procedures and confirming theoretical predictions. Specifically, this dissertation introduces four methods that make possible the design and fabrication of RF channel-select filters. The first of these introduces a small-signal equivalent circuit for parallel-plate capacitive-gap transduced micromechanical resonators that employs negative capacitance to model the dependence of resonance frequency on electrical stiffness in a way that facilitates the analysis of micromechanical circuits loaded with arbitrary electrical impedances. The new circuit model not only correctly predicts the dependence of electrical stiffness on the impedances loading the input and output electrodes of parallel-plate capacitive-gap transduced micromechanical device, but does so in a visually intuitive way that identifies current drive as most appropriate for

  18. Occupational RF Exposures (invited paper)

    Energy Technology Data Exchange (ETDEWEB)

    Jokela, K.; Puranen, L

    1999-07-01

    Potentially adverse levels of RF electromagnetic fields, exceeding the present limits for occupational exposure, arise near industrial high frequency (HF) heaters, high power broadcast antennas, and high power radar antennas. Other significant emitters of RF fields in the occupational environment are radiotelephones, induction heaters, short-wave and microwave therapy devices, base station antennas, magnetic resonance imaging devices, microwave ovens, and industrial microwave heaters. In terms of the intensity and duration of the exposure as well as the number of exposed workers, the HF sealers, particularly plastic sealers, constitute the most significant RF radiation safety problem in the working environment. (author)

  19. Residential RF Exposures (invited paper)

    Energy Technology Data Exchange (ETDEWEB)

    Dahme, M

    1999-07-01

    In many areas of the world there are publications on Governmental Regulations, Standards or Guidelines to protect workers and the general public against harmful effects of exposure to electromagnetic fields. Against this background, information is given about different radiation sources of electromagnetic fields in the RF part of the spectrum, which may be typical for residential exposure. Relevant radiation characteristics of the sources and field strength numbers and distributions are given. In addition some general aspects of field structure in the near- and far-field of RF radiation sources are described. On this basis principles of measurement and calculation of RF fields are explained. (author)

  20. Novel Photonic RF Spectrometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Leveraging on recent breakthroughs in broadband photonic devices and components for RF and microwave applications, SML proposes a new type of broadband microwave...

  1. Unbalanced field RF electron gun

    Science.gov (United States)

    Hofler, Alicia

    2013-11-12

    A design for an RF electron gun having a gun cavity utilizing an unbalanced electric field arrangement. Essentially, the electric field in the first (partial) cell has higher field strength than the electric field in the second (full) cell of the electron gun. The accompanying method discloses the use of the unbalanced field arrangement in the operation of an RF electron gun in order to accelerate an electron beam.

  2. Concepts for a short wavelength rf gun

    Science.gov (United States)

    Kuzikov, S. V.; Shchelkunov, S.; Vikharev, A. A.

    2017-03-01

    Three concepts of an rf gun to be operated at 0.1-10 mm wavelengths are considered. In all the concepts, the rf system exploits an accelerating traveling wave. In comparison with a classical decimeter standing-wave rf gun, we analyze the advantages of new concepts, available rf sources, and achievable beam parameters.

  3. Patient-reported outcomes after electron radiation treatment for early-stage palmar and plantar fibromatosis.

    Science.gov (United States)

    Schuster, Jessica; Saraiya, Siddharth; Tennyson, Nathan; Nedelka, Michele; Mukhopadhyay, Nitai; Weiss, Elisabeth

    2015-01-01

    Palmar and plantar fibromatosis (PPF) is a progressive connective tissue disorder of the hand/foot that often leads to debilitating functional impairment. In Europe, orthovoltage radiation therapy (RT) has been demonstrated to prevent local disease progression for up to 80% of patients with early-stage PPF. There are limited data reporting outcomes for populations outside of Europe or using electron RT. Between 2008 and 2013, 44 early-stage PPF cases received RT. RT fields involved clinically defined targets encompassing involved areas (skin changes, cords, nodules) with at least 1.5-cm margins. En face electrons (6-12 MeV) and bolus (0.5-1 cm) were selected individually. Outcomes are reported for patients who participated in an institutional review board-approved standardized questionnaire and chart review. Thirty-three patients received 66 treatments (45 hands/15 feet and 6 reirradiations). Most frequent dose schemes were 21 Gy (3 Gy in 7 fractions) and 30 Gy (3 Gy in 10 fractions with 6- to 8-week breaks after 15 Gy). Median time to follow-up survey was 31 months. Disease progression at any location within or outside the RT treatment field occurred in 20 of 33 patients (61%). Fourteen of 60 sites (23%) developed in-field progression, but 4 sites were successfully reirradiated with final local control in 50 of 60 sites (83%). RT improved pretreatment symptoms of pain with strain at 30 of 37 sites (81%) and itch/burn sensations at 17 of 21 sites (81%). There were no reported grade ≥2 late toxicities even with reirradiation. Patient reported overall success with treatment was 31 of 33 patients (94%). PPF is a progressive disease. En face electron RT is an effective therapy that stabilizes or improves symptoms in the majority of patients. Reirradiation can be considered as a treatment option for in-field progression. Patients report minimal toxicity and a high rate of satisfaction with treatment. Copyright © 2015 American Society for Radiation Oncology. Published

  4. Diode laser versus scalpel in the treatment of hereditary gingival fibromatosis in a 6-year old boy

    Directory of Open Access Journals (Sweden)

    Samia Aboujaoude

    2016-11-01

    Full Text Available Hereditary gingival fibromatosis (HGF is a rare disease characterized by a benign enlargement of the gingiva involving both the mandible and the maxilla. This case is about a 6-year-old child with non syndromic HGF showing a severe gingival enlargement covering almost all surfaces of the teeth, in both arches, hence causing major aesthetic, phonetic and masticatory problems. The aim of the present article is to compare the outcomes of two therapeutical approaches: i classical surgical removal with scalpel; and ii diode laser resection. Compared to the surgical approach, the clinical results show that the main advantages of the diode laser technique are a better visibility during the intervention, minimal postoperative discomfort combined to a better gingival recontouring. However, the time consumption and the high cost of the laser equipment remain the main disadvantages of the systematic use of this technique.

  5. Diode Laser Versus Scalpel in the Treatment of Hereditary Gingival Fibromatosis in a 6-Year Old Boy

    Science.gov (United States)

    Aboujaoude, Samia; Cassia, Antoine; Moukarzel, Carla

    2016-01-01

    Hereditary gingival fibromatosis (HGF) is a rare disease characterized by a benign enlargement of the gingiva involving both the mandible and the maxilla. This case is about a 6-year-old child with non syndromic HGF showing a severe gingival enlargement covering almost all surfaces of the teeth, in both arches, hence causing major aesthetic, phonetic and masticatory problems. The aim of the present article is to compare the outcomes of two therapeutical approaches: i) classical surgical removal with scalpel; and ii) diode laser resection. Compared to the surgical approach, the clinical results show that the main advantages of the diode laser technique are a better visibility during the intervention, minimal postoperative discomfort combined to a better gingival recontouring. However, the time consumption and the high cost of the laser equipment remain the main disadvantages of the systematic use of this technique. PMID:27994842

  6. An unusual cause of duodenal obstruction: mesenteric fibromatosis in a patient with type I Mayer-Rokitansky-Kuster-Hauser syndrome.

    Science.gov (United States)

    Turgutalp, Kenan; Tabakan, Feray; Kara, Tuğba; Gübür, Ozlem; Altıntaş, Engin; Türkmenoğlu, Ozgür; Ozhan, Onur; Kıykım, Ahmet; Apaydın, F Demir

    2014-02-01

    Patients with mesenteric fibromatosis (MF) are clinically asymptomatic, with little or no focal symptoms until later in their course, at which time they complain of pain, abdominal discomfort, constipation, vomiting, abdominal mass, weight loss, and symptoms due to organ compression. Generally, it occurs as an abdominal mass but may also present in many different ways. In some cases, trauma, previous abdominal surgery, and hormonal stimulation (such as estrogen) may play a role in onset of this neoplasm. Patients with Mayer-Rokitansky-Kuster-Hauser syndrome present primary amenorrhea and may have some other anomalies, including hearing defects, heart defects, skeletal deformities, and genital neoplastic diseases. We diagnosed duodenal obstruction due to MF in a patient with type I Mayer-Rokitansky-Kuster-Hauser syndrome.

  7. RF Group Annual Report 2011

    CERN Document Server

    Angoletta, M E; Betz, M; Brunner, O; Baudrenghien, P; Calaga, R; Caspers, F; Ciapala, E; Chambrillon, J; Damerau, H; Doebert, S; Federmann, S; Findlay, A; Gerigk, F; Hancock, S; Höfle, W; Jensen, E; Junginger, T; Liao, K; McMonagle, G; Montesinos, E; Mastoridis, T; Paoluzzi, M; Riddone, G; Rossi, C; Schirm, K; Schwerg, N; Shaposhnikova, E; Syratchev, I; Valuch, D; Venturini Delsolaro, W; Völlinger, C; Vretenar, M; Wuensch, W

    2012-01-01

    The highest priority for the RF group in 2011 was to contribute to a successful physics run of the LHC. This comprises operation of the superconducting 400 MHz accelerating system (ACS) and the transverse damper (ADT) of the LHC itself, but also all the individual links of the injector chain upstream of the LHC – Linac2, the PSB, the PS and the SPS – don’t forget that it is RF in all these accelerators that truly accelerates! A large variety of RF systems had to operate reliably, often near their limit. New tricks had to be found and implemented to go beyond limits; not to forget the equally demanding operation with Pb ions using in addition Linac3 and LEIR. But also other physics users required the full attention of the RF group: CNGS required in 2011 beams with very short, intense bunches, AD required reliable deceleration and cooling of anti-protons, Isolde the post-acceleration of radioactive isotopes in Rex, just to name a few. In addition to the supply of beams for physics, the RF group has a num...

  8. An RF-input outphasing power amplifier with RF signal decomposition network

    OpenAIRE

    Barton, Taylor W.; Perreault, David J.

    2015-01-01

    This work presents an outphasing power amplifier that directly amplifies a modulated RF input. The approach eliminates the need for multiple costly IQ modulators and baseband signal component separation found in conventional outphasing power amplifier systems, which have previously required both an RF carrier input and a separate baseband input to synthesize a modulated RF output. A novel RF signal decomposition network enables direct RF-input / RF-output outphasing by directly synthesizing t...

  9. "Whisking of ugly tissue"… A surgical management of gingival fibromatosis in a 15-year-old girl: A rare case report

    Directory of Open Access Journals (Sweden)

    Srinivasa Tenkasale Siddeshappa

    2015-01-01

    Full Text Available Gingival fibromatosis is a condition characterized by a slow, progressive increase in the gingival tissue that develops as either an isolated disorder or as part of the clinical characteristics of diverse syndrome. The present case report describes a rare case of gingival fibromatosis and its management using scalpel in combination with electrosurgery. A 15-year-old girl patient presented with a chief complaint of gingival overgrowth covering all the surfaces upper and lower teeth. The growth was excised with periodontal knife in combination with electrosurgery under local anesthesia. After 1-year of follow-up, healing was uneventful with no recurrence. Combined technique for the removal of gingival overgrowth represents a unique treatment approach where minimal postoperative bleeding and discomfort were observed.

  10. Gold-gold sulfide nanoshell as a novel intensifier for anti-tumor effects of radiofrequency fields

    Directory of Open Access Journals (Sweden)

    Hamid Reza Sadeghi

    2014-07-01

    Conclusion: This study showed that RF radiation can markedly reduce the tumor growth in presence of GGS. Hence, it can be predicted that GGS nanoshells convert sub-lethal effects of noninvasive RF fields into lethal damages

  11. Cryogenic vacuumm RF feedthrough device

    Science.gov (United States)

    Wu, Genfa [Yorktown, VA; Phillips, Harry Lawrence [Hayes, VA

    2008-12-30

    A cryogenic vacuum rf feedthrough device comprising: 1) a probe for insertion into a particle beam; 2) a coaxial cable comprising an inner conductor and an outer conductor, a dielectric/insulating layer surrounding the inner conductor, the latter being connected to the probe for the transmission of higher mode rf energy from the probe; and 3) a high thermal conductivity stub attached to the coaxial dielectric about and in thermal contact with the inner conductor which high thermal conductivity stub transmits heat generated in the vicinity of the probe efficiently and radially from the area of the probe and inner conductor all while maintaining useful rf transmission line characteristics between the inner and outer coaxial conductors.

  12. Ion bombardment in RF photoguns

    Energy Technology Data Exchange (ETDEWEB)

    Pozdeyev,E.; Kayran, D.; Litvinenko, V. N.

    2009-05-04

    A linac-ring eRHIC design requires a high-intensity CW source of polarized electrons. An SRF gun is viable option that can deliver the required beam. Numerical simulations presented elsewhere have shown that ion bombardment can occur in an RF gun, possibly limiting lifetime of a NEA GaAs cathode. In this paper, we analytically solve the equations of motion of ions in an RF gun using the ponderomotive potential of the Rf field. We apply the method to the BNL 1/2-cell SRF photogun and demonstrate that a significant portion of ions produced in the gun can reach the cathode if no special precautions are taken. Also, the paper discusses possible mitigation techniques that can reduce the rate of ion bombardment.

  13. RF breakdown by toroidal helicons

    Indian Academy of Sciences (India)

    S K P Tripathi; D Bora; M Mishra

    2001-04-01

    Bounded whistlers are well-known for their efficient plasma production capabilities in thin cylindrical tubes. In this paper we shall present their radio frequency (RF) breakdown and discharge sustaining capabilities in toroidal systems. Pulsed RF power in the electronmagnetohydrodynamic (EMHD) frequency regime is fed to the neutral background medium. After the breakdown stage, discharge is sustained by toroidal bounded whistlers. In these pulsed experiments the behaviour of the time evolution of the discharge could be studied in four distinct phases of RF breakdown, steady state attainment, decay and afterglow. In the steady state average electron density of ≈ 1012 per cc and average electron temperature of ≈ 20 eV are obtained at 10-3 mbar of argon filling pressure. Experimental results on toroidal mode structure, background effects and time evolution of the electron distribution function will be presented and their implications in understanding the breakdown mechanism are discussed.

  14. RF Loads for Energy Recovery

    CERN Document Server

    Federmann, S; Caspers, F

    2012-01-01

    Different conceptional designs for RF high power loads are presented. One concept implies the use of solid state rectifier modules for direct RF to DC conversion with efficiencies beyond 80%. In addition, robust metallic low-Q resonant structures, capable of operating at high temperatures (>150 ◦C) are discussed. Another design deals with a very high temperature (up to 800 ◦C) air cooled load using a ceramic foam block inside a metal enclosure. This porous ceramic block is the microwave absorber and is not brazed to the metallic enclosure.

  15. Huge Facial Desmoid Tumors with Neck Extension: A Case Report

    Directory of Open Access Journals (Sweden)

    Ali Ghazipour

    2014-07-01

    Full Text Available Introduction: Desmoid tumors are very rare, benign fibrous neoplasms arise from the musculoaponeurotic structures throughout the body.   Case Report: The patient was a   seven-year old boy with a large mandibular mass growing over a period of six months. His CT-scan showed a large mass, 13 cm in diameter in the cheek area extending to the neck and trachea. Biopsy was compatible with desmoid fibromatosis.  He was given neoadjovant treatment with vinblastin and methotrexate. The patient underwent a tracheostomy. Then a complete hemimandibulectomy and submandibular gland excision was performed.  Finally reconstruction with latisimus dorsi free flap was performed.   Conclusion: Despite rarity desmoid tumors should be kept in mind of an otorhinolaryngologist as a differential diagnosis in children with head and neck mass.  

  16. Negative ion source with external RF antenna

    Science.gov (United States)

    Leung, Ka-Ngo; Hahto, Sami K.; Hahto, Sari T.

    2007-02-13

    A radio frequency (RF) driven plasma ion source has an external RF antenna, i.e. the RF antenna is positioned outside the plasma generating chamber rather than inside. The RF antenna is typically formed of a small diameter metal tube coated with an insulator. An external RF antenna assembly is used to mount the external RF antenna to the ion source. The RF antenna tubing is wound around the external RF antenna assembly to form a coil. The external RF antenna assembly is formed of a material, e.g. quartz, which is essentially transparent to the RF waves. The external RF antenna assembly is attached to and forms a part of the plasma source chamber so that the RF waves emitted by the RF antenna enter into the inside of the plasma chamber and ionize a gas contained therein. The plasma ion source is typically a multi-cusp ion source. A converter can be included in the ion source to produce negative ions.

  17. Radio frequency-mediated local thermotherapy for destruction of pancreatic tumors using Ni-Au core-shell nanowires

    Science.gov (United States)

    Hopkins, Xiaoping; Gill, Waqas Amin; Kringel, Rosemarie; Wang, Guankui; Hass, Jamie; Acharya, Suresh; Park, Jungrae; Tak Jeon, In; An, Boo Hyun; Lee, Ji Sung; Ryu, Jong Eun; Hill, Rod; McIlroy, David; Kim, Young Keun; Choi, Daniel S.

    2017-01-01

    We present a novel method of radio frequency (RF)-mediated thermotherapy in tumors by remotely heating nickel (Ni)-gold (Au) core-shell nanowires (CSNWs). Ectopic pancreatic tumors were developed in nude mice to evaluate the thermotherapeutic effects on tumor progression. Tumor ablation was produced by RF-mediated thermotherapy via activation of the paramagnetic properties of the Ni-Au CSNWs. Histopathology demonstrated that heat generated by RF irradiation caused significant cellular death with pyknotic nuclei and nuclear fragmentation dispersed throughout the tumors. These preliminary results suggest that thermotherapy ablation induced via RF activation of nanowires provides a potential alternative therapy for cancer treatment.

  18. Broadband direct RF digitization receivers

    CERN Document Server

    Jamin, Olivier

    2014-01-01

    This book discusses the trade-offs involved in designing direct RF digitization receivers for the radio frequency and digital signal processing domains.  A system-level framework is developed, quantifying the relevant impairments of the signal processing chain, through a comprehensive system-level analysis.  Special focus is given to noise analysis (thermal noise, quantization noise, saturation noise, signal-dependent noise), broadband non-linear distortion analysis, including the impact of the sampling strategy (low-pass, band-pass), analysis of time-interleaved ADC channel mismatches, sampling clock purity and digital channel selection. The system-level framework described is applied to the design of a cable multi-channel RF direct digitization receiver. An optimum RF signal conditioning, and some algorithms (automatic gain control loop, RF front-end amplitude equalization control loop) are used to relax the requirements of a 2.7GHz 11-bit ADC. A two-chip implementation is presented, using BiCMOS and 65nm...

  19. The LHC Low Level RF

    CERN Document Server

    Baudrenghien, Philippe; Molendijk, John Cornelis; Olsen, Ragnar; Rohlev, Anton; Rossi, Vittorio; Stellfeld, Donat; Valuch, Daniel; Wehrle, Urs

    2006-01-01

    The LHC RF consists of eight 400 MHz superconducting cavities per ring, with each cavity independently powered by a 300 kW klystron, via a circulator. The challenge for the Low Level is to cope with very high beam current (more than 1 A RF component) and achieve excellent beam lifetime (emittance growth time in excess of 25 hours). Each cavity has an associated Cavity Controller rack consisting of two VME crates which implement high gain RF Feedback, a Tuner Loop with a new algorithm, a Klystron Ripple Loop and a Conditioning system. In addition each ring has a Beam Control system (four VME crates) which includes a Frequency Program, Phase Loop, Radial Loop and Synchronization Loop. A Longitudinal Damper (dipole and quadrupole mode) acting via the 400 MHz cavities is included to reduce emittance blow-up due to filamentation from phase and energy errors at injection. Finally an RF Synchronization system implements the bunch into bucket transfer from the SPS into each LHC ring. When fully installed in 2007, the...

  20. MOSFET Degradation Under RF Stress

    NARCIS (Netherlands)

    Sasse, G.T.; Kuper, F.G.; Schmitz, Jurriaan

    2008-01-01

    We report on the degradation of MOS transistors under RF stress. Hot-carrier degradation, negative-bias temperature instability, and gate dielectric breakdown are investigated. The findings are compared to established voltage- and field-driven models. The experimental results indicate that the

  1. Automatic calorimetry system monitors RF power

    Science.gov (United States)

    Harness, B. W.; Heiberger, E. C.

    1969-01-01

    Calorimetry system monitors the average power dissipated in a high power RF transmitter. Sensors measure the change in temperature and the flow rate of the coolant, while a multiplier computes the power dissipated in the RF load.

  2. Simulation of synchrotron motion with rf noise

    Energy Technology Data Exchange (ETDEWEB)

    Leemann, B.T.; Forest, E.; Chattopadhyay, S.

    1986-08-01

    The theoretical formulation is described that is behind an algorithm for synchrotron phase-space tracking with rf noise and some preliminary simulation results of bunch diffusion under rf noise obtained by actual tracking.

  3. The Imaging Diagnosis of Aggressive Fibromatosis%侵袭性纤维瘤病的影像诊断价值

    Institute of Scientific and Technical Information of China (English)

    张雷; 迟达; 赵丹; 路鹏; 辛英; 李森; 罗娅红

    2014-01-01

    Objective To assess the value of imaging examination in diagnosing aggressive fibromatosis.Methods CT and MRI findings of 69 patients with pathologically-proved aggressive fibromatosis were retrospectively analyzed.Results Abdominal wall type of aggressive fibromatosis was seen in 14 females in childbearing age,while extra-abdominal or intra-abdominal type of aggressive fibromatosis was seen in 27 females and 28 males.On CT scans,all the lesions showed homogeneous slight low-density (n =18),or inhomogeneous mild-lower or higher density (n =16) with enhancement.In 46 cases,the lesions showed iso-intensity or slightly long T1 and slightly long T2 signal,with short T2 signals,which became obviously enhanced after the injection of contrast.Conclusion Aggressive fibromatosis has certain CT and MRI characteristics,which are very helpful in diagnosing and differentiating this disease.%目的 探讨侵袭性纤维瘤病(AF)的影像诊断价值.方法 回顾性分析经手术和病理证实的69例AF的CT和MRI表现.结果 14例腹壁型均为育龄期女性,腹外型及腹腔型男、女分别为27例、28例.CT上18例为均匀稍低密度,16例呈稍低-稍高混杂密度,增强后稍低密度区逐渐强化;46例MRI表现为等或稍长T1、稍长T2信号,伴有范围不等的短T2信号,增强后等或稍长T1、稍长T2信号区强化明显,短T2信号区轻微强化.结论 AF的CT和MRI表现具有一定特征性,影像检查对该病的诊断和鉴别诊断有重要价值.

  4. Thallium-201 scintigraphy for bone and soft tissue tumors

    Energy Technology Data Exchange (ETDEWEB)

    Tokuumi, Yuji; Tsuchiya, Hiroyuki; Sunayama, Chiaki; Matsuda, Eizo; Asada, Naohiro; Taki, Junichi; Sumiya, Hisashi; Miyauchi, Tsutomu; Tomita, Katsuro [Kanazawa Univ. (Japan). School of Medicine

    1995-05-01

    This study was undertaken to assess the usefulness of thallium-201 scintigraphy in bone and soft tissue tumors. Pre-therapy scintigraphy was undertaken in a total of 136 patients with histologically confirmed diagnosis, consisting of 74 with malignant bone and soft tissue tumors, 39 with benign ones, 12 with diseases analogous to tumors, and 11 others. Thallium activity was graded on a scale of 0-4: 0=background activity, 1=equivocal activity, 2=definitive activity, but less than myocardium, 3=definite activity equal to myocardium, and 4=activity greater than myocardium. In the group of malignant tumors, thallium-201 uptake was found in 80%, although it was low for chondrosarcoma (2/8) and malignant Schwannoma (one/3). The group of benign tumors, however, showed it in only 41%, being restricted to those with giant cell tumors, chondroblastoma, fibromatosis, and osteoid osteoma. Thallium-201 uptake was also found in all 8 patients with metastatic tumors. In 23 patients undergoing thallium imaging before and after chemotherapy, scintigraphic findings revealed a high correlation with histopathological findings. Thus, thallium-201 scintigraphy may be potentially used to distinguish malignant from benign bone and soft tissue tumors, except for a few histopathological cases, as well as to determine loco-regional metastases and response to chemotherapy. (N.K.).

  5. On the theory of photocathode rf guns

    Institute of Scientific and Technical Information of China (English)

    GAO Jie

    2009-01-01

    In this paper we give a set of analytical formulae to describe the characteristics of photocathode rf guns at any rf frequencies, such as energy, energy spread, bunch length, out going current, and emittance etc.as functions of the laser injection phase, which are useful in the design and practical operation of rf guns.

  6. High-brightness rf linear accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Jameson, R.A.

    1986-01-01

    The issue of high brightness and its ramifications in linacs driven by radio-frequency fields is discussed. A history of the RF linacs is reviewed briefly. Some current applications are then examined that are driving progress in RF linacs. The physics affecting the brightness of RF linacs is then discussed, followed by the economic feasibility of higher brightness machines. (LEW)

  7. RF power coupling for the CSNS DTL

    Institute of Scientific and Technical Information of China (English)

    刘华昌; 彭军; 殷学军; 欧阳华甫; 傅世年

    2011-01-01

    The China Spallation Neutron Source (CSNS) drift tube linac (DTL) consists of four tanks and each tank is fed by a 2.5 MW klystron. Accurate predication of RF coupling between the RF cavity and ports is very important for DTL RF coupler design. An iris-ty

  8. High-brightness rf linear accelerators

    Energy Technology Data Exchange (ETDEWEB)

    Jameson, R.A.

    1986-01-01

    The issue of high brightness and its ramifications in linacs driven by radio-frequency fields is discussed. A history of the RF linacs is reviewed briefly. Some current applications are then examined that are driving progress in RF linacs. The physics affecting the brightness of RF linacs is then discussed, followed by the economic feasibility of higher brightness machines. (LEW)

  9. RF power coupling for the CSNS DTL

    Science.gov (United States)

    Liu, Hua-Chang; Peng, Jun; Yin, Xue-Jun; Ouyang, Hua-Fu; Fu, Shi-Nian

    2011-01-01

    The China Spallation Neutron Source (CSNS) drift tube linac (DTL) consists of four tanks and each tank is fed by a 2.5 MW klystron. Accurate predication of RF coupling between the RF cavity and ports is very important for DTL RF coupler design. An iris-type coupler is chosen to couple the RF power to the DTL accelerating cavity. The physical design of the DTL coupler and the calculations of RF coupling between the cavity and coupler are carried out. The results from the numerical simulations are in excellent agreement with the analytical results.

  10. RF power coupling for the CSNS DTL

    Institute of Scientific and Technical Information of China (English)

    LIU Hua-Chang; PENG Jun; YIN Xue-Jun; OUYANG Hua-Fu; FU Shi-Nian

    2011-01-01

    The China Spallation Neutron Source(CSNS)drift tube linac(DTL)consists of four tanks and each tank is fed by a 2.5 MW klystron.Accurate predication of RF coupling between the RF cavity and ports is very important for DTL RF coupler design.An iris-type coupler is chosen to couple the RF power to the DTL accelerating cavity.The physical design of the DTL coupler and the calculations of RF coupling between the cavity and coupler are carried out.The results from the numerical simulations are in excellent agreement with the analytical results.

  11. Parameter optimization of temperature field in RF-capacitive hyperthermia

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To realize a certain target temperature distribution in tumor tissues and avoid over-heating in normal tissues in radio frequency (RF)-capacitive hyperthermia, an objective function and some weight coefficients are introduced. Then using the 2-D finite element method, the electromagnetic and bio-heat transfer equations are solved, and using the genetic algorithm the heating configurations are recursively modified to minimize the objective function. Finally an optimum solution of the expected heating field distribution in hyperthermia is achieved. And with a human heterogeneous tissue model extracted from X-ray CT images, satisfactory optimization results are obtained in the simulations on a biplate RF-capacitive hyperthermia device. This optimization technique for controlling the body temperature field has shown scientific importance and practical values in the research of hyperthermia.

  12. Protection of Accelerator Hardware: RF systems

    CERN Document Server

    Kim, S-H

    2016-01-01

    The radio-frequency (RF) system is the key element that generates electric fields for beam acceleration. To keep the system reliable, a highly sophisticated protection scheme is required, which also should be designed to ensure a good balance between beam availability and machine safety. Since RF systems are complex, incorporating high-voltage and high-power equipment, a good portion of machine downtime typically comes from RF systems. Equipment and component damage in RF systems results in long and expensive repairs. Protection of RF system hardware is one of the oldest machine protection concepts, dealing with the protection of individual high-power RF equipment from breakdowns. As beam power increases in modern accelerators, the protection of accelerating structures from beam-induced faults also becomes a critical aspect of protection schemes. In this article, an overview of the RF system is given, and selected topics of failure mechanisms and examples of protection requirements are introduced.

  13. RF Microalgal lipid content characterization

    Science.gov (United States)

    Ahmad, Mahmoud Al; Al-Zuhair, Sulaiman; Taher, Hanifa; Hilal-Alnaqbi, Ali

    2014-05-01

    Most conventional techniques for the determination of microalgae lipid content are time consuming and in most cases are indirect and require excessive sample preparations. This work presents a new technique that utilizes radio frequency (RF) for rapid lipid quantification, without the need for sample preparation. Tests showed that a shift in the resonance frequency of a RF open-ended coaxial resonator and a gradual increase in its resonance magnitude may occur as the lipids content of microalgae cells increases. These response parameters can be then calibrated against actual cellular lipid contents and used for rapid determination of the cellular lipids. The average duration of lipid quantification using the proposed technique was of about 1 minute, which is significantly less than all other conventional techniques, and was achieved without the need for any time consuming treatment steps.

  14. Linearisation of RF Power Amplifiers

    DEFF Research Database (Denmark)

    Nielsen, Per Asbeck

    2001-01-01

    This thesis deals with linearisation techniques of RF power amplifiers (PA), PA design techniques and integration of the necessary building blocks in a CMOS technology. The opening chapters introduces the theory of transmitter architectures, RF-signal representation and the principles of digital...... modulation. Furthermore different types of power amplifiers, models and measures of non-linearities are presented. A chapter is also devoted to different types of linearisation systems. The work carried out and described in this thesis can be divided into a more theoretical and system oriented treatment...... the polar loop architecture and it’s suitability to modern digital transmitters is discussed. A proposal of an architecture that is suitable for digital transmitters, which means that it has an interface to the digital back-end, defined by low-pass signals in polar form, is presented. Simulation guidelines...

  15. SPS RF System a Tetrode

    CERN Multimedia

    1974-01-01

    The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also gradually increased: by end 1980 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412016X, 7412017X, 7411048X.

  16. [Development of RF coil of permanent magnet mini-magnetic resonance imager and mouse imaging experiments].

    Science.gov (United States)

    Hou, Shulian; Xie, Huantong; Chen, Wei; Wang, Guangxin; Zhao, Qiang; Li, Shiyu

    2014-10-01

    In the development of radio frequency (RF) coils for better quality of the mini-type permanent magnetic resonance imager for using in the small animal imaging, the solenoid RF coil has a special advantage for permanent magnetic system based on analyses of various types.of RF coils. However, it is not satisfied for imaging if the RF coils are directly used. By theoretical analyses of the magnetic field properties produced from the solenoid coil, the research direction was determined by careful studies to raise further the uniformity of the magnetic field coil, receiving coil sensitivity for signals and signal-to-noise ratio (SNR). The method had certain advantages and avoided some shortcomings of the other different coil types, such as, birdcage coil, saddle shaped coil and phased array coil by using the alloy materials (from our own patent). The RF coils were designed, developed and made for keeled applicable to permanent magnet-type magnetic resonance imager, multi-coil combination-type, single-channel overall RF receiving coil, and applied for a patent. Mounted on three instruments (25 mm aperture, with main magnetic field strength of 0.5 T or 1.5 T, and 50 mm aperture, with main magnetic field strength of 0.48 T), we performed experiments with mice, rats, and nude mice bearing tumors. The experimental results indicated that the RF receiving coil was fully applicable to the permanent magnet-type imaging system.

  17. Low jitter RF distribution system

    Science.gov (United States)

    Wilcox, Russell; Doolittle, Lawrence; Huang, Gang

    2012-09-18

    A timing signal distribution system includes an optical frequency stabilized laser signal amplitude modulated at an rf frequency. A transmitter box transmits a first portion of the laser signal and receive a modified optical signal, and outputs a second portion of the laser signal and a portion of the modified optical signal. A first optical fiber carries the first laser signal portion and the modified optical signal, and a second optical fiber carries the second portion of the laser signal and the returned modified optical signal. A receiver box receives the first laser signal portion, shifts the frequency of the first laser signal portion outputs the modified optical signal, and outputs an electrical signal on the basis of the laser signal. A detector at the end of the second optical fiber outputs a signal based on the modified optical signal. An optical delay sensing circuit outputs a data signal based on the detected modified optical signal. An rf phase detect and correct signal circuit outputs a signal corresponding to a phase stabilized rf signal based on the data signal and the frequency received from the receiver box.

  18. Correlation of MRI and pathology in aggressive fibromatosis%侵袭性纤维瘤病的MRI表现与病理对照

    Institute of Scientific and Technical Information of China (English)

    杨献峰; 江波; 朱斌; 王冬梅; 王坤; 田传帅; 周正扬

    2012-01-01

    Objective To analyse the MRI characteristics of aggressive fibromatosis (AF) ,and to explore the correlation between MRI findings and pathological manifestations.Methods All the 15 cases of AF were confirmed by surgical pathology.MR images of 6 specimens of the tumors were obtained, gross specimen sections were prepared in line with MR images,then rountine HE staining and Masson trichrome staining were perfomed.The signal intensity and margins of tumors were analysed on MRI, the tumor components were observed under microscope, and comparison was made between MRI and pathological findings.Results Single lesion was developed in 14 cases,the tumors located in the hip in A , abdominal wall in 3,armpit in 2 and extremities in 5.One patient had multiple lesions in hip and extremities.The tumors developed along the long axis of muscle.The tumor margins were well defined in 1 case, poorly defined in 5 and partially poorly defined in 9.The signal intensity of the lesions was mostly near homogeneous or homogeneous.The signal intensity was equal to that of muscle on T1WI, and slightly higher than muscle and lower than fat on T2WI.Asterism-like and streak-like areas with hypointensity were seen in the lesions (15 foci) on T2WI,and no necrosis or hemorrhage.The foci showed moderate to strong enhancement after intravenous contrast administration.It was revealed by microscopic study that the tumors were consisted of elongated spindle cells of uniform appearance, surrounding and separating from each other by collagen.Cellularity and amount of collagen varied in different areas.Compact cellular areas showed higher SI than the other areas.Areas with low SI represented foci of collagen.Conclusion There are specific MRI findings for AF, which can demonstrate its his-tologic features.%目的 探讨侵袭性纤维瘤病的MRI表现及其病理学基础.方法 回顾分析15例侵袭性纤维瘤病的MRI表现,并获取手术标本的MR图像,对照图像切面对6例肿瘤手术标本

  19. Multispeciality Approach in the Management of Patient with Hereditary Gingival Fibromatosis: 1-Year Followup: A Case Report

    Directory of Open Access Journals (Sweden)

    T. Ramakrishnan

    2010-01-01

    Full Text Available Background. Hereditary gingival fibromatosis is a fibrotic enlargement of the gingiva. It may exist as an isolated abnormality or as part of multisystem syndrome. This paper reports a case of 16-year-old male with generalized severe gingival overgrowth, involving the maxillary and mandibular arches and covering almost all teeth. Methods. Periodontal management of gingival enlargement included gingivectomy in both arches except in the lower right molar region where flap surgery was done under general anesthesia. After a 2-month followup period, orthodontic treatment was started with fixed appliances. Monthly periodontal checkups and maintainance (scaling and polishing were scheduled to control the gingival inflammation. Results. Reevaluation of the patient of surgical treatment after two months did not show any recurrence of condition; however, minimal overgrowth was noted 1 month after the beginning of orthodontic treatment which was treated nonsurgically. Conclusions. Although the risk of recurrence is high with this condition, surgical treatment with correction of malocclusion and regular followup can provide excellent outcome as seen in this case.

  20. Clinical features and treatment of aggressive fibromatosis%纤维瘤病109例临床特征与治疗

    Institute of Scientific and Technical Information of China (English)

    宁晓红; 白春梅; 应红艳; 王毓洲

    2010-01-01

    Objective To study the clinical features and treatment of aggressive fibromatosis ( AF). Methods One hundred and nine the clinical characters, treatment and efficacy of each patient were reviewed. Results One hundred and nine pathologically diagnosed AF patients presented in Peking Union Medical College Hospital ( PUMCH) was analyzed. 70 females and 39 males were included with an average age of 34.0 and 36.9 yrs respec-tively. 87.2% of patients first presented as mass, 33.7% first presented as mass accompanying pain. 32. 1% of mass located in the abdomen wall among which 94. 3% were female, 51.5% of these females had a history of sur-gery of the abdomen. Diameter of all the masses was(7. 84 ±5.62)cm, diameter of deep mass was statistically lar-ger than that of superior ones, which were(11. 1 ±5.9)cm and(6. 8 ±5. 1 )cm respectively,P <0. 01. Twelve pa-tients got radiotherapy and 8 of them did it for the purpose of preventing disease recurrence. 7 out of them recurrent within an average interval of about 2. 7 years. A patient whose tumor was located in the anterior mediastinum was treated with chemotherapy and had a partial response. 4 patients died of AF. Conclusion Operation is still most widely used therapeutic option. Radiotherapy is also effective in certain percentage of patients and medicine such as chemotherapy or NSAlDs that have not been receipted.%目的 分析纤维瘤病的临床特点及治疗.方法 对我院1986年1月1日至2008年12月31日间确诊的109例纤维瘤病患者的临床特征、治疗情况进行总结分析.结果 109例患者中女性70例,男性39例,87.2%的患者是以肿块为首发症状,肿块伴疼痛占33.7%,32.1%(35/109例)肿块发生在腹壁,腹壁肿块患者中女性达94.3%.直径5 cm及以上肿块占70.5%.深部肿块直径明显大于浅表肿块,直径分别为(11.1±5.9)cm和(6.8±5.1)cm,P<0.01.12例患者接受过放射治疗,8例以预防术后复发为目的的患者7例出现放疗后

  1. Recurrent angio-fibroma of breast masquerading as phyllodes tumor.

    Science.gov (United States)

    Chaurasia, Jai K; Alam, Feroz; Shadan, Mariam; Naim, Mohammed

    2015-01-01

    A young Indian female presented with a recurring tumor in the right breast masquerading as phyllodes tumor. Patient had history of five times excision and recurrences of the tumor, diagnosed as fibrous phyllodes of the breast. Presently, a well-circumscribed tumor of about 10 cm size, comprising of benign fibrous-angiomatous tissue with evidence of foci of pyogenic vasculitis was observed. Immuno-histochemical markers for the myo-epithelial and epithelial elements excluded the possibility of fibrous phyllodes, inflammatory myofibroblastic tumor, desmoid fibromatosis, and metaplastic carcinoma. The present findings were diagnostic of an inflammatory angio-fibroma of the right breast, not reported in the earlier literature. The observations indicated that the female breast may be susceptible to spontaneous productive and common-antibiotic-resistant focal septic vascular inflammation giving rise to angio-fibromatous proliferation producing a well-defined tumor mass in the breast, distinguishable from the other breast lesions by the connective tissue stains and immuno-histochemical markers.

  2. Moscow Meson Factory DTL RF System Upgrade

    CERN Document Server

    Esin, S K; Kvasha, A I; Serov, V L

    2004-01-01

    The last paper devoted to description of the first part (DTL) RF system of Moscow Meson Factory upgrade was published in the Proceedings of PAC95 Conference in Dallas. Since then some new works directed at improvement of reliability and efficiency of the RF system were carried out. Among them there are a new powerful pulse triode “Katran” installed in the output RF power amplifiers (PA) of three channels, modifications of the anode modulator control circuit and crow-bar system, a new additional RF channel for RF supply of RFQ and some alterations in placing of the anode modulator equipment decreasing a level of interference’s at crow-bar circuits. Some new checked at MMF RF channels ideas concerning of PA tuning are of interest for people working in this sphere of activity.

  3. RF and microwave microelectronics packaging II

    CERN Document Server

    Sturdivant, Rick

    2017-01-01

    Reviews RF, microwave, and microelectronics assembly process, quality control, and failure analysis Bridges the gap between low cost commercial and hi-res RF/Microwave packaging technologies Engages in an in-depth discussion of challenges in packaging and assembly of advanced high-power amplifiers This book presents the latest developments in packaging for high-frequency electronics. It is a companion volume to “RF and Microwave Microelectronics Packaging” (2010) and covers the latest developments in thermal management, electrical/RF/thermal-mechanical designs and simulations, packaging and processing methods, and other RF and microwave packaging topics. Chapters provide detailed coverage of phased arrays, T/R modules, 3D transitions, high thermal conductivity materials, carbon nanotubes and graphene advanced materials, and chip size packaging for RF MEMS. It appeals to practicing engineers in the electronic packaging and high-frequency electronics domain, and to academic researchers interested in underst...

  4. Overview of the RF Systems for LCLS

    CERN Document Server

    McIntosh, Peter; Boyce, Richard; Emma, Paul; Hill, Alan; Rago, Carl

    2005-01-01

    The Linac Coherent Light Source (LCLS) at SLAC, when it becomes operational in 2009, will provide its user community with an X-ray source many orders of magnitude brighter than anything available in the world at that time. The electron beam acceleration will be provided by existing and new RF systems capable of maintaining the amplitude and phase stability of each bunch to extremely tight tolerances. RF feedback control of the various RF systems will be fundamental in ensuring the beam arrives at the LCLS undulator at precisely the required energy and phase. This paper details the requirements for RF stability for the various LCLS RF systems and also highlights proposals for how these injector and Linac RF systems can meet these constraints.

  5. Indeterminate soft-tissue tumors of the hand and wrist: a review based on a clinical series of 39 cases

    Energy Technology Data Exchange (ETDEWEB)

    Sookur, Paul A. [West Middlesex University Hospital, Department of Radiology, Isleworth, Middlesex (United Kingdom); Saifuddin, Asif [The Royal National Orthopaedic Hospital, Department of Radiology, Stanmore (United Kingdom)

    2011-08-15

    Soft-tissue masses located at the hand and wrist are a frequent clinical presentation. The majority of these are ganglia, which have characteristic imaging features. Other common masses in which a diagnosis is suggested by imaging include hemangiomas, lipomas, and focal synovitis. The remainder are rare although a diagnosis may be attempted by considering the patients' age and the location. We reviewed 39 soft-tissue masses at the hand and wrist referred to our institution between September 1998 and January 2006 that had indeterminate imaging features. The majority were benign neoplastic lesions with the most common being a giant cell tumor of the tendon sheath, followed by angioleiomyoma, peripheral nerve sheath tumor, fibromatosis, fibroma of tendon sheath, and solitary fibrous tumor. These lesions tend to occur in young adults at the metacarpal level. However, there are no imaging features that can reliably differentiate between benign and malignant tumors. (orig.)

  6. Topology optimized RF MEMS switches

    DEFF Research Database (Denmark)

    Philippine, M. A.; Zareie, H.; Sigmund, Ole

    2013-01-01

    Topology optimization is a rigorous and powerful method that should become a standard MEMS design tool - it can produce unique and non-intuitive designs that meet complex objectives and can dramatically improve the performance and reliability of MEMS devices. We present successful uses of topology...... optimization for an RF MEM capacitive switch. Extensive experimental data confirms that the switches perform as designed by the optimizations, and that our simulation models are accurate. A subset of measurements are presented here. Broader results have been submitted in full journal format....

  7. MEMS technologies for rf communications

    Science.gov (United States)

    Wu, Qun; Kim, B. K.

    2001-04-01

    Microelectromechanical system (MEMS) represents an exciting new technology derived from the same fabricating processes used to make integrated circuits. The trends of growing importance of the wireless communications market is toward the system with minimal size, cost and power consumption. For the purpose of MEMS R&D used for wireless communications, a history and present situation of MEMS device development are reviewed in this paper, and an overview of MEMS research topics on RF communication applications and the state of the art technologies are also presented here.

  8. 142例侵袭性纤维瘤病的临床特点及预后分析%The clinical characteristics and prognostic factors of aggressive fibromatosis in 142 patients

    Institute of Scientific and Technical Information of China (English)

    曹玲; 赵路军; 刘宁波; 张柏林; 伊帅; 王平

    2011-01-01

    Objective Aggressive fibromatosis is a rare kind of soft tissue tumor and was evaluated by few large studies. This study was to evaluate the clinical characteristics and identify the prognostic factors of this disease. Methods One hundred and forty-two patients with aggressive fibromatosis treated from January 1983 to August 2009 in Tianjin Medical University Cancer Hospital were retrospectively reviewed.The prognostic value of clinical and treatment factors was analyzed. Univariate analysis was performed with Log-rank test and Multivariate analysis was performed with Cox regression model. Results The follow-up rate is 93.7% and the median follow up time was 54 months (range,6 -208 months). Sixty-three patients had a minimum follow up time of 5 years and 6 patients had a minimum follow up time of 10 years. The male/female ratio was 1/1.84. The disease was most popular in women aged from 18 to 35 years old. The disease frequently occurred in the trunk (55.6%) and extremity (31.7%). All patients received surgery,and 46 received radiotherapy. The 5-year and 10-year local recurrence rates were 24. 4% and 31.1%,respectively. The 5-year and 10-year overall survival rates were both 99. 3%. Univariate analysis revealed that factors correlated with local recurrence were tumor size ( χ2 = 4. 37, P = 0. 037 ) and margin status (χ2 = 12. 36,P =0. 002). Multivariate analysis revealed that margin status was an independent risk factor (RR = 2. 219; χ2 = 9. 47,P = 0. 002) and radiotherapy was an independent protective factor ( RR = 0. 360;χ2 = 4. 95, P = 0. 026 ) for disease recurrence. When radiotherapy was delivered, the 10-year local recurrence rate decreased from 70. 1% to 20. 7% in patients with positive margin ( χ2 = 4. 22, P = 0. 040 )and decreased from 19.8% to 10.4% (χ2= 0.90, P= 0.344) in patients with negative margin.Conclusions Radical resection is the mainstay of treatment for aggressive fibromatosis. Postoperative radiotherapy can reduce the recurrent rate for

  9. A LOW NOISE RF SOURCE FOR RHIC.

    Energy Technology Data Exchange (ETDEWEB)

    HAYES,T.

    2004-07-05

    The Relativistic Heavy Ion Collider (RHIC) requires a low noise rf source to ensure that beam lifetime during a store is not limited by the rf system. The beam is particularly sensitive to noise from power line harmonics. Additionally, the rf source must be flexible enough to handle the frequency jump required for rebucketing (transferring bunches from the acceleration to the storage rf systems). This paper will describe the design of a Direct Digital Synthesizer (DDS) based system that provides both the noise performance and the flexibility required.

  10. Muon Ionisation Cooling in Reduced RF

    CERN Document Server

    Prior, G

    2010-01-01

    In Muon Ionisation Cooling, closely packed high-field RF cavities are interspersed with energy-absorbing material in order to reduce particle beam emittance. Transverse focussing of the muon beams is achieved by superconducting magnets. This results in the RF cavities sitting in intense magnetic fields. Recent studies have shown that this may limit the peak gradient that can be achieved in the RF cavities. In this paper, we study the effect that a reduced RF gradient may have on the cooling performance of the Neutrino Factory lattice and examine methods to mitigate the effect.

  11. RF front-end world class designs

    CERN Document Server

    Love, Janine

    2009-01-01

    All the design and development inspiration and direction a harware engineer needs in one blockbuster book! Janine Love site editor for RF Design Line,columnist, and author has selected the very best RF design material from the Newnes portfolio and has compiled it into this volume. The result is a book covering the gamut of RF front end design from antenna and filter design fundamentals to optimized layout techniques with a strong pragmatic emphasis. In addition to specific design techniques and practices, this book also discusses various approaches to solving RF front end design problems and h

  12. Ion tracking in photocathode rf guns

    Directory of Open Access Journals (Sweden)

    John W. Lewellen

    2002-02-01

    Full Text Available Projected next-generation linac-based light sources, such as PERL or the TESLA free-electron laser, generally assume, as essential components of their injector complexes, long-pulse photocathode rf electron guns. These guns, due to their design rf pulse durations of many milliseconds to continuous wave, may be more susceptible to ion bombardment damage of their cathodes than conventional rf guns, which typically use rf pulses of microsecond duration. This paper explores this possibility in terms of ion propagation within the gun, and presents a basis for future study of the subject.

  13. RF Breakdown in Drift Tube Linacs

    CERN Document Server

    Stovall, J; Lown, R

    2009-01-01

    The highest RF electric field in drift-tube linacs (DTLs) often occurs on the face of the first drift tube. Typically this drift tube contains a quadrupole focusing magnet whose fringing fields penetrate the face of the drift tube parallel to the RF electric fields in the accelerating gap. It has been shown that the threshold for RF breakdown in RF cavities may be reduced in the presence of a static magnetic field. This note offers a “rule of thumb” for picking the maximum “safe” surface electric field in DTLs based on these measurements.

  14. RF/optical shared aperture for high availability wideband communication RF/FSO links

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, Anthony J; Pao, Hsueh-yuan; Sargis, Paul

    2014-04-29

    An RF/Optical shared aperture is capable of transmitting and receiving optical signals and RF signals simultaneously. This technology enables compact wide bandwidth communications systems with 100% availability in clear air turbulence, rain and fog. The functions of an optical telescope and an RF reflector antenna are combined into a single compact package by installing an RF feed at either of the focal points of a modified Gregorian telescope.

  15. RF/optical shared aperture for high availability wideband communication RF/FSO links

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, Anthony J; Pao, Hsueh-yuan; Sargis, Paul

    2015-03-24

    An RF/Optical shared aperture is capable of transmitting and receiving optical signals and RF signals simultaneously. This technology enables compact wide bandwidth communications systems with 100% availability in clear air turbulence, rain and fog. The functions of an optical telescope and an RF reflector antenna are combined into a single compact package by installing an RF feed at either of the focal points of a modified Gregorian telescope.

  16. JLEIC SRF cavity RF Design

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Shaoheng [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Guo, Jiquan [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Wang, Haipeng [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Rimmer, Robert A. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States)

    2016-05-01

    The initial design of a low higher order modes (HOM) impedance superconducting RF (SRF) cavity is presented in this paper. The design of this SRF cavity is for the proposed Jefferson Lab Electron Ion Collider (JLEIC). The electron ring of JLEIC will operate with electrons of 3 to 10 GeV energy. The ion ring of JLEIC will operate with protons of up to 100 GeV energy. The bunch lengths in both rings are ~12 mm (RMS). In order to maintain the short bunch length in the ion ring, SRF cavities are adopted to provide large enough gradient. In the first phase of JLEIC, the PEP II RF cavities will be reused in the electron ring to lower the initial cost. The frequency of the SRF cavities is chosen to be the second harmonic of PEP II cavities, 952.6 MHz. In the second phase of JLEIC, the same frequency SRF cavities may replace the normal conducting PEP II cavities to achieve higher luminosity at high energy. At low energies, the synchro-tron radiation damping effect is quite weak, to avoid the coupled bunch instability caused by the intense closely-spaced electron bunches, low HOM impedance of the SRF cavities combined with longitudinal feedback sys-tem will be necessary.

  17. SPS RF System Amplifier plant

    CERN Multimedia

    1977-01-01

    The picture shows a 2 MW, 200 MHz amplifier plant with feeder lines. The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also increased: to the first 2 MW plant a second 2 MW plant was added and by end 1979 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412016X, 7412017X, 7411048X.

  18. Direct RF modulation transmitter, sampling clock frequency setting method for direct RF modulation transmitter

    NARCIS (Netherlands)

    Fukuda, Shuichi; Nauta, Bram

    2013-01-01

    PROBLEM TO BE SOLVED: To provide a direct RF modulation transmitter capable of satisfying a radiation level regulation even without providing a SAW filter. SOLUTION: A direct RF modulation transmitter includes: digital/RF converters 105, 106 to which an I digital baseband signal, a Q digital baseb

  19. Fibromatosis gingival, amelogénesis imperfecta, retardo en la erupción dental y retardo en el crecimiento y desarrollo. ¿Un nuevo síndrome?

    National Research Council Canada - National Science Library

    Pablo Molano; Abraham Blank; Oscar Tamayo; Carolina Isaza

    2009-01-01

    .... Se informa la asociación de fibromatosis gingival, amelogénesis imperfecta, retardo en la erupción dental, y retardo severo en el crecimiento y desarrollo en una niña de 11 años. Se estudia...

  20. Management of sporadic desmoid-type fibromatosis: A European consensus approach based on patients' and professionals' expertise - A Sarcoma Patients EuroNet and European Organisation for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group initiative

    NARCIS (Netherlands)

    Kasper, B.; Baumgarten, C.; Bonvalot, S.; Haas, R; Haller, F.; Hohenberger, P.; Moreau, G.; Graaf, W.T.A. van der; Gronchi, A.

    2015-01-01

    Desmoid-type fibromatosis (DF) is a rare monoclonal, fibroblastic proliferation characterised by a variable and often unpredictable clinical course. It may affect nearly all parts of the body including extremities, trunk and abdomen. Considering the variable clinical presentations, anatomic location

  1. Fibromatosis gingival, amelogénesis imperfecta, retardo en la erupción dental y retardo en el crecimiento y desarrollo. ¿Un nuevo síndrome?

    Directory of Open Access Journals (Sweden)

    Pablo Molano

    2009-10-01

    Full Text Available La fibromatosis pertenece a un grupo de proliferaciones de infiltrado fibroso, que exhibe una conducta clínica y un potencial biológico intermedio entre la lesión fibrosa benigna y el fibrosarcoma. Se denomina fibromatosis gingival a la que compromete la mucosa oral, tanto en la región de la tuberosidad maxilar superior como en la encía de los maxilares superiores e inferiores. Varios síndromes multisistémicos se han asociado con fibromatosis gingival. Se informa la asociación de fibromatosis gingival, amelogénesis imperfecta, retardo en la erupción dental, y retardo severo en el crecimiento y desarrollo en una niña de 11 años. Se estudia su núcleo familiar y se describen en detalle los aspectos clínicos, de laboratorio y de patología. La revisión de la literatura no reveló todas estas asociaciones, por lo que se propone este caso como un nuevo síndrome.

  2. Breast tissue characterization using FARMA modeling of ultrasonic RF echo.

    Science.gov (United States)

    Alacam, Burak; Yazici, Birsen; Bilgutay, Nihat; Forsberg, Flemming; Piccoli, Catherine

    2004-10-01

    A number of empirical and analytical studies demonstrated that the ultrasound RF echo reflected from tissue exhibits 1/f characteristics. In this paper, we propose to model 1/f characteristics of the ultrasonic RF echo by a novel parsimonious model, namely the fractional differencing auto regressive moving average (FARMA) process, and evaluated diagnostic value of model parameters for breast cancer malignancy differentiation. FARMA model captures the fractal and long term correlated nature of the backscattered speckle texture and facilitates robust efficient estimation of fractal parameters. In our study, in addition to the computer generated FARMA model parameters, we included patient age and radiologist's prebiopsy level of suspicion (LOS) as potential indicators of malignant and benign masses. We evaluated the performance of the proposed set of features using various classifiers and training methods using 120 in vivo breast images. Our study shows that the area under the receiver operating characteristics (ROC) curve of FARMA model parameters alone is superior to the area under the ROC curve of the radiologist's prebiopsy LOS. The area under the ROC curve of the three sets of features yields a value of 0.87, with a confidence interval of [0.85, 0.89], at a significance level of 0.05. Our results suggest that the proposed method of ultrasound RF echo model leads to parameters that can differentiate breast tumors with a relatively high precision. This set of RF echo features can be incorporated into a comprehensive computer-aided diagnostic system to aid physicians in breast cancer diagnosis.

  3. Bone tumor

    Science.gov (United States)

    Tumor - bone; Bone cancer; Primary bone tumor; Secondary bone tumor; Bone tumor - benign ... The cause of bone tumors is unknown. They often occur in areas of the bone that grow rapidly. Possible causes include: Genetic defects ...

  4. Diagnostic problems of abdominal desmoid tumors in various locations

    Energy Technology Data Exchange (ETDEWEB)

    Kreuzberg, B. [Department of Diagnostic Radiology, Faculty Hospital and Medical Faculty of Charles University, Alej Svobody 80, 30460 Pilsen (Czech Republic)]. E-mail: kreuzberg@fnplzen.cz; Koudelova, J. [Department of Diagnostic Radiology, Faculty Hospital and Medical Faculty of Charles University, Alej Svobody 80, 30460 Pilsen (Czech Republic); Ferda, J. [Department of Diagnostic Radiology, Faculty Hospital and Medical Faculty of Charles University, Alej Svobody 80, 30460 Pilsen (Czech Republic); Treska, V. [Department of Surgery, Faculty Hospital and Medical Faculty of Charles University, Alej Svobody 80, 30460 Pilsen (Czech Republic); Spidlen, V. [Department of Surgery, Faculty Hospital and Medical Faculty of Charles University, Alej Svobody 80, 30460 Pilsen (Czech Republic); Mukensnabl, P. [Sikl' s Department of Pathology, Faculty Hospital and Medical Faculty of Charles University, Alej Svobody 80, 30460 Pilsen (Czech Republic)

    2007-05-15

    Background: Abdominal desmoid tumor is one of the forms of deep (musculoaponeurotic) fibromatosis. It occurs more often as a desmoid tumor in the abdominal wall, less often in various intra-abdominal locations. In this work, we performed retrospective study concerning diagnostic problems of this disease with the use of imaging techniques. Method: Four patients (three females and one male) were examined by postcontrast CT (computed tomography) and one of them also by MR (magnetic resonance). All findings were correlated with the operational findings and histologic examination. Results: The findings were typical only in the case with the lesion located in the abdominal wall, three described cases of the intra-abdominal desmoid provided a broad range of differentially diagnostic possibilities (metastases, GIT tumors, lymphomas, etc.). In particular, the findings in infiltrative processes in intra-abdominal location and retroperitoneal involvement were less typical. Ultimately, the histological findings were decisive. Conclusion: The possibility of the occurrence of intra-abdominal desmoid tumor must be considered particularly in younger individuals with rapidly growing tumorous process, which does not immediately arise from the surrounding organs (digestive tract, internal genitalia, etc.), and is located in the abdominal wall or in the abdominal cavity.

  5. Multipacting simulation in accelerating RF structures

    Energy Technology Data Exchange (ETDEWEB)

    Gusarova, M.A.; Kaminsky, V.I. [Moscow Engineering Physics Institute, State University (Russian Federation); Kravchuk, L.V. [Institute for Nuclear Research of Russian Academy of Sciences (Russian Federation); Kutsaev, S.V. [Moscow Engineering Physics Institute, State University (Russian Federation)], E-mail: s_kutsaev@mail.ru; Lalayan, M.V.; Sobenin, N.P. [Moscow Engineering Physics Institute, State University (Russian Federation); Tarasov, S.G. [Institute for Nuclear Research of Russian Academy of Sciences (Russian Federation)

    2009-02-01

    A new computer code for 3D simulation of multipacting phenomenon in axisymmetric and non-axisymmetric radio frequency (RF) structures is presented. The goal of the simulation is to determine resonant electron trajectories and electron multiplication in RF structure. Both SW and TW structures of normal and superconductivity have been studied. Simulation results are compared with theoretical calculations and experimental measurements.

  6. 17th International Conference on RF Superconductivity

    CERN Document Server

    2015-01-01

    RF superconductivity is the key technology of accelerators for particle physics, nuclear physics and light sources. SRF 2015 covered the latest advances in the science, technology, and applications of superconducting RF. There was also an industrial exhibit during the conference with the key vendors in the community available to discuss their capabilities and products.

  7. 17th International Conference on RF Superconductivity

    CERN Document Server

    Laxdal, Robert E.; Schaa, Volker R.W.

    2015-01-01

    RF superconductivity is the key technology of accelerators for particle physics, nuclear physics and light sources. SRF 2015 covered the latest advances in the science, technology, and applications of superconducting RF. There was also an industrial exhibit during the conference with the key vendors in the community available to discuss their capabilities and products.

  8. LTE RF subsystem power consumption modeling

    DEFF Research Database (Denmark)

    Musiige, Deogratius; Vincent, Laulagnet; Anton, François;

    2012-01-01

    This paper presents a new power consumption emulation model, for all possible scenarios of the RF subsystem, when transmitting a LTE signal. The model takes the logical interface parameters, Tx power, carrier frequency and bandwidth between the baseband and RF subsystem as inputs to compute the p...

  9. 47 CFR 95.1221 - RF exposure.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false RF exposure. 95.1221 Section 95.1221... SERVICES Medical Device Radiocommunication Service (MedRadio) § 95.1221 RF exposure. MedRadio medical... chapter) are subject to the radiofrequency radiation exposure requirements specified in §§ 1.1307 and 2...

  10. RF power generation for future linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Fowkes, W.R.; Allen, M.A.; Callin, R.S.; Caryotakis, G.; Eppley, K.R.; Fant, K.S.; Farkas, Z.D.; Feinstein, J.; Ko, K.; Koontz, R.F.; Kroll, N.; Lavine, T.L.; Lee, T.G.; Miller, R.H.; Pearson, C.; Spalek, G.; Vlieks, A.E.; Wilson, P.B.

    1990-06-01

    The next linear collider will require 200 MW of rf power per meter of linac structure at relatively high frequency to produce an accelerating gradient of about 100 MV/m. The higher frequencies result in a higher breakdown threshold in the accelerating structure hence permit higher accelerating gradients per meter of linac. The lower frequencies have the advantage that high peak power rf sources can be realized. 11.42 GHz appears to be a good compromise and the effort at the Stanford Linear Accelerator Center (SLAC) is being concentrated on rf sources operating at this frequency. The filling time of the accelerating structure for each rf feed is expected to be about 80 ns. Under serious consideration at SLAC is a conventional klystron followed by a multistage rf pulse compression system, and the Crossed-Field Amplifier. These are discussed in this paper.

  11. RF Transceiver Design for MIMO Wireless Communications

    CERN Document Server

    Mohammadi, Abbas

    2012-01-01

    This practical resource offers a thorough examination of RF transceiver design for MIMO communications.  Offering a practical view on MIMO wireless systems, this book extends fundamental concepts on classic wireless transceiver design techniques to MIMO transceivers. This helps reader gain a very comprehensive understanding of the subject. This in-depth volume describes many theoretical and implementation challenges on MIMO transceivers and provides the practical solutions for these issues. This comprehensive book provides thorough descriptions of MIMO theoretical concepts, MIMO single carrier and OFDM modulation, RF transceiver design concepts, power amplifier, MIMO transmitter design techniques and their RF impairments, MIMO receiver design methods, RF impairments study including nonlinearity, DC-offset, I/Q imbalance and phase noise and their compensation in OFDM and MIMO techniques. In addition, it provides the most practical techniques to realize RF front-ends in MIMO systems. This book is supported wit...

  12. Operation experience with the LHC RF system

    CERN Document Server

    Arnaudon, L; Brunner, O; Butterworth, A

    2010-01-01

    The LHC ACS RF system is composed of 16 superconducting cavities, eight per ring, housed in a total of four cryomodules each containing four cavities. Each cavity is powered by a 300 kW klystron. The ACS RF power control system is based on industrial Programmable Logic Controllers (PLCs), with additional fast RF interlock protection systems. The Low Level RF (LLRF) is implemented in VME crates. Operational performance and reliability are described. A full set of user interfaces, both for experts and operators has been developed, with user feedback and maintenance issues as key points. Operational experience with the full RF chain, including the low level system, the beam control, the synchronization system and optical fibers distribution is presented. Last but not least overall performance and reliability based on experience with first beam are reviewed and perspectives for future improvement outlined.

  13. RF Jitter Modulation Alignment Sensing

    Science.gov (United States)

    Ortega, L. F.; Fulda, P.; Diaz-Ortiz, M.; Perez Sanchez, G.; Ciani, G.; Voss, D.; Mueller, G.; Tanner, D. B.

    2017-01-01

    We will present the numerical and experimental results of a new alignment sensing scheme which can reduce the complexity of alignment sensing systems currently used, while maintaining the same shot noise limited sensitivity. This scheme relies on the ability of electro-optic beam deflectors to create angular modulation sidebands in radio frequency, and needs only a single-element photodiode and IQ demodulation to generate error signals for tilt and translation degrees of freedom in one dimension. It distances itself from current techniques by eliminating the need for beam centering servo systems, quadrant photodetectors and Gouy phase telescopes. RF Jitter alignment sensing can be used to reduce the complexity in the alignment systems of many laser optical experiments, including LIGO and the ALPS experiment.

  14. New Driver For The Powerful Output Rf Amplifier Of Mmf Dtl Rf System

    CERN Document Server

    Kvasha, A I; Vassilyev, A G

    2004-01-01

    More than 30 years ago a few powerful vacuum tubes were specially designed and produced in the former design office Swetlana for the Moscow meson factory DTL RF system. Among them was tetrode GI-51A with output pulse RF power up to 300 kW at frequency 198.2 MHz, which was used as driver for RF power amplifier with output RF pulse power (2-3) MW. In connection with well-known events in our country manufacture of these tubes, including GI-51A was finished about 10 years ago. In "SED-SPb" (successor of the design office Swetlana) triode GI-57A was offered instead of GI-51A. In this paper results of calculations and design of RF amplifier with new triode are presented. Preliminary results of RF amplifier tests, also presented in the paper, showed that triode GI-57A will be able successfully used in the DTL RF system channels.

  15. VERSE-Guided Numerical RF Pulse Design: A Fast Method for Peak RF Power Control

    Science.gov (United States)

    Lee, Daeho; Grissom, William A.; Lustig, Michael; Kerr, Adam B.; Stang, Pascal P.; Pauly, John M.

    2013-01-01

    In parallel excitation, the computational speed of numerical radiofrequency (RF) pulse design methods is critical when subject dependencies and system nonidealities need to be incorporated on-the-fly. One important concern with optimization-based methods is high peak RF power exceeding hardware or safety limits. Hence, online controllability of the peak RF power is essential. Variable-rate selective excitation pulse reshaping is ideally suited to this problem due to its simplicity and low computational cost. In this work, we first improve the fidelity of variable-rate selective excitation implementation for discrete-time waveforms through waveform oversampling such that variable-rate selective excitation can be robustly applied to numerically designed RF pulses. Then, a variable-rate selective excitation-guided numerical RF pulse design is suggested as an online RF pulse design framework, aiming to simultaneously control peak RF power and compensate for off-resonance. PMID:22135085

  16. Femtosecond precision measurement of laser-rf phase jitter in a photocathode rf gun

    Science.gov (United States)

    Shi, Libing; Zhao, Lingrong; Lu, Chao; Jiang, Tao; Liu, Shengguang; Wang, Rui; Zhu, Pengfei; Xiang, Dao

    2017-03-01

    We report on the measurement of the laser-rf phase jitter in a photocathode rf gun with femtosecond precision. In this experiment four laser pulses with equal separation are used to produce electron bunch trains; then the laser-rf phase jitter is obtained by measuring the variations of the electron bunch spacing with an rf deflector. Furthermore, we show that when the gun and the deflector are powered by the same rf source, it is possible to obtain the laser-rf phase jitter in the gun through measurement of the beam-rf phase jitter in the deflector. Based on these measurements, we propose an effective time-stamping method that may be applied in MeV ultrafast electron diffraction facilities to enhance the temporal resolution.

  17. Installation and Commissioning of CYCIAE-100 RF Cavity

    Institute of Scientific and Technical Information of China (English)

    JI; Bin; XING; Jian-sheng; LIU; Geng-shou; YIN; Zhi-guo; ZHANG; Tian-jue; LEI; Yu; FU; Xiao-liang; LI; Peng-zhan; LV; Yin-long; ZHU; Peng-fei; FU; Li-cheng; LIU; Jie; ZHANG; De-zhi; CUI; Bai-yao; DONG; Huan-jun; WANG; Zhen-hui

    2013-01-01

    The RF cavity is used to establish electrical field for the particle acceleration in the cyclotron,the stability of the RF cavity affects the RF system directly.A RF cavity with high quality can reduce thepower consumption of the RF system and make the cooling system simple.A good design is the first step towards RF cavity with high quality.The installation and commissioning are the next important process to achieve an excellent performance.The height of the

  18. [Gene expression profile of the peripheral CD4(+)T cells in patients with RF(+) and RF(-) rheumatoid arthritis].

    Science.gov (United States)

    Lu, Cheng; Xu, Shi-jie; Xiao, Cheng; Yan, Xiao-ping; Zhao, Lin-hua; Wang, Jian-ming; Li, Shao; Lu, Ai-ping

    2008-02-01

    To explore the differences of the gene expression of CD4(+) lymphocytes between the RF(+) and RF(-) patients with rheumatoid arthritis. mRNA of all the CD4(+) lymphocytes samples were extracted and identified. Then they were labeled and hybridized to microarrays. Hierarchical clustering analysis showed there were 55 differential expression genes between the RF(+) and RF(-) patients with rheumatoid arthritis. There are differential expression genes between the RF(+) and RF(-) patients and these genes are related to immunoresponse.

  19. Matching network for RF plasma source

    Science.gov (United States)

    Pickard, Daniel S.; Leung, Ka-Ngo

    2007-11-20

    A compact matching network couples an RF power supply to an RF antenna in a plasma generator. The simple and compact impedance matching network matches the plasma load to the impedance of a coaxial transmission line and the output impedance of an RF amplifier at radio frequencies. The matching network is formed of a resonantly tuned circuit formed of a variable capacitor and an inductor in a series resonance configuration, and a ferrite core transformer coupled to the resonantly tuned circuit. This matching network is compact enough to fit in existing compact focused ion beam systems.

  20. Practical guide to RF-MEMS

    CERN Document Server

    Iannacci, Jacopo

    2013-01-01

    Closes the gap between hardcore-theoretical and purely experimental RF-MEMS books. The book covers, from a practical viewpoint, the most critical steps that have to be taken in order to develop novel RF-MEMS device concepts. Prototypical RF-MEMS devices, both including lumped components and complex networks, are presented at the beginning of the book as reference examples, and these are then discussed from different perspectives with regard to design, simulation, packaging, testing, and post-fabrication modeling. Theoretical concepts are introduced when necessary to complement the practical

  1. RF engineering basic concepts: S-parameters

    CERN Document Server

    Caspers, F

    2011-01-01

    The concept of describing RF circuits in terms of waves is discussed and the S-matrix and related matrices are defined. The signal flow graph (SFG) is introduced as a graphical means to visualize how waves propagate in an RF network. The properties of the most relevant passive RF devices (hybrids, couplers, non-reciprocal elements, etc.) are delineated and the corresponding S-parameters are given. For microwave integrated circuits (MICs) planar transmission lines such as the microstrip line have become very important.

  2. Experimental Study on RF Hollow Cathode Discharge

    Institute of Scientific and Technical Information of China (English)

    甘肇强; 吴雪梅; 姚伟国

    2001-01-01

    By using a longitudinal static magnetic field, we have shown that it is possible to excite an intensive plasma in a simple stainless steel tube which is connected with a RF power supply. Under certain conditions, the very bright Ar Ⅱ lines were excited. The emission intensities of Ar Ⅱ lines were increased with the increase in RF power, magnetic field, and the decrease in argon pressure. As the plasma-sheath boundary oscillating under the RF voltage, the plasma column is periodically compressed by the oscillating boundary.``

  3. RF Power and HOM Coupler Tutorial

    Energy Technology Data Exchange (ETDEWEB)

    Rusnak, B

    2003-10-28

    Radio frequency (RF) couplers are used on superconducting cavities to deliver RF power for creating accelerating fields and to remove unwanted higher-order mode power for reducing emittance growth and cryogenic load. RF couplers in superconducting applications present a number of interdisciplinary design challenges that need to be addressed, since poor performance in these devices can profoundly impact accelerator operations and the overall success of a major facility. This paper will focus on critical design issues for fundamental and higher order mode (HOM) power couplers, highlight a sampling of reliability-related problems observed in couplers, and discuss some design strategies for improving performance.

  4. RF and Surface Properties of Superconducting Samples

    CERN Document Server

    Junginger, T; Weingarten, W; Welsch, C

    2011-01-01

    At CERN a compact Quadrupole Resonator has been developed for the RF characterization of superconducting samples at different frequencies. In this paper, results from measurements on bulk niobium and niobium filmon copper substrate samples are presented. We show how different contributions to the surface resistance depend on temperature, applied RF magnetic field and frequency. Furthermore, measurements of the maximum RF magnetic field as a function of temperature and frequency in pulsed and CW operation are presented. The study is accompanied by measurements of the surface properties of the samples by various techniques.

  5. Focal adenomyosis (intramural endometriotic cyst) in a very young patient - differential diagnosis with uterine fibromatosis

    Science.gov (United States)

    Manta, L; Suciu, N; Constantin, A; Toader, O; Popa, F

    2016-01-01

    Introduction. Adenomyosis is a widespread disease usually affecting the late reproductive years of the women’s life, which has a great impact on their fertility. The most common form is diffuse adenomyosis, while focal adenomyosis, a cystic variant, is very rare, particularly in patients younger than 30 years old. Materials and methods. We reported a rare case of a 20-year-old Caucasian woman with cystic adenomyosis who was admitted in our service with severe chronic pelvic pain, dysmenorrhea, and menorrhagia, who had received conservative surgical treatment to preserve fertility and improve her obstetrical prognosis. Results and Discussions. Although the necrobiosis of a uterine fibroid was suspected preoperatively, the extemporaneous histopathological exam revealed adenomyosis associated with fibroleiomyoma with hyaline dystrophy and multiple foci of endometriosis of cystic formation in the wall of a young woman without any risk factors. Conclusion. Although a rare lesion in young patients, cystic adenomyosis should be considered when chronic pelvic pain is exacerbated during menstruation and is associated with a uterine tumor. In young patients, the differential diagnosis should be made with uterine malformations (hematometra), necrobiosis of uterine fibroids, pelvic endometriosis. The surgical treatment should be conservative with the excision of the lesion, always taking into account fertility preservation in young patients. PMID:27453751

  6. Childhood Fibroblastic and Myofibroblastic Tumors: A Multicenter Documentation and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Ayper KAÇAR

    2012-01-01

    Full Text Available Objective: In this study, we aimed to give a documentation of 37 cases of childhood fibroblastic/myofibroblastic tumors retrieved from the archives of 6 reference centers in Ankara along with a comprehensive review on the subject.Material and Method: A retrospective archive search was carried out for the period between 2006-2010 in 6 reference centers in Ankara covering patients with ages ranging between 0-18 years. All the tumors categorized under fibroblastic and myofibroblastic group according to World Health Organization criteria were collected.Results: The study comprised 407 soft tissue tumors in total. Fibroblastic/myofibroblastic tumors constituted 9,1 % (37 cases of these tumors. According to histopathology; 16 cases were categorized as fibromatosis, 8 cases as inflammatory myofibroblastic tumor, 6 cases as infantile fibrous hamartoma, 3 cases as nodular fasciitis and 2 cases as infantile myofibroblastic tumor/myofibromatosis and 1 case as cranial fasciitis. The only malignant case was an infantile fibrosarcoma.Conclusion: Infantile fibrosarcoma was lower than reported series and a male predominance was noted. The low incidence of newly described entities as well suggests that these tumors may have been unrecognized.

  7. TESLA superconducting RF cavity development

    Energy Technology Data Exchange (ETDEWEB)

    Koepke, K. [Fermi National Accelerator Lab., Batavia, IL (United States); TESLA Collaboration

    1995-05-01

    The TESLA collaboration has made steady progress since its first official meeting at Cornell in 1990. The infrastructure necessary to assemble and test superconducting rf cavities has been installed at the TESLA Test Facility (TTF) at DESY. 5-cell, 1.3 GHz cavities have been fabricated and have reached accelerating fields of 25 MV/m. Full sized 9-cell copper cavities of TESLA geometry have been measured to verify the higher order modes present and to evaluate HOM coupling designs. The design of the TESLA 9-cell cavity has been finalized and industry has started delivery. Two prototype 9-cell niobium cavities in their first tests have reached accelerating fields of 10 MV/m and 15 MV/m in a vertical dewar after high peak power (HPP) conditioning. The first 12 m TESLA cryomodule that will house 8 9-cell cavities is scheduled to be delivered in Spring 1995. A design report for the TTF is in progress. The TTF test linac is scheduled to be commissioned in 1996/1997. (orig.).

  8. KSTAR RF heating system development

    Energy Technology Data Exchange (ETDEWEB)

    Kwak, J. G.; Kim, S. K.; Hwang, C. K. (and others)

    2007-10-15

    Design, high-voltage test, and installation of 6 MW ICRF heating system for KSTAR is completed. The antenna demonstrated satisfactory standoff at high voltages up to 41 kV for 300 sec. The result indicates good power handling capabilities of the antenna as high as 10 MW/m2. This power density is equivalent to RF power coupling of 6 MW into a 4 {omega}/m target plasma, and is typical of advanced tokamak heating scenarios. In addition, vacuum feed through, DC break, and liquid stub developed for 300 sec operation are installed, as well as a 2 MW, 30-60MHz transmitter. The transmitter successfully produced output powers of 600 kW continuously, 1.5{approx}1.8 MW for 300 sec, and 2 MW for 100 msec or shorter pulses. A realtime control system based on DSP and EPICS is developed, installed, and tested on the ICRF system. Initial results from feasibility study indicate that the present antenna and the transmission lines could allow load-resilient operation on KSTAR. Until the KSTAR tokamak start to produce plasmas in 2008, however, hands-on operational experiences are obtained from participating in ICRF heating experiments at ASDEX and DIII-D tokamaks arranged through international cooperation.

  9. RF Localization in Indoor Environment

    Directory of Open Access Journals (Sweden)

    M. Stella

    2012-06-01

    Full Text Available In this paper indoor localization system based on the RF power measurements of the Received Signal Strength (RSS in WLAN environment is presented. Today, the most viable solution for localization is the RSS fingerprinting based approach, where in order to establish a relationship between RSS values and location, different machine learning approaches are used. The advantage of this approach based on WLAN technology is that it does not need new infrastructure (it reuses already and widely deployed equipment, and the RSS measurement is part of the normal operating mode of wireless equipment. We derive the Cramer-Rao Lower Bound (CRLB of localization accuracy for RSS measurements. In analysis of the bound we give insight in localization performance and deployment issues of a localization system, which could help designing an efficient localization system. To compare different machine learning approaches we developed a localization system based on an artificial neural network, k-nearest neighbors, probabilistic method based on the Gaussian kernel and the histogram method. We tested the developed system in real world WLAN indoor environment, where realistic RSS measurements were collected. Experimental comparison of the results has been investigated and average location estimation error of around 2 meters was obtained.

  10. FERMILAB CRYOMODULE TEST STAND RF INTERLOCK SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Troy [Fermilab; Diamond, J. S. [Fermilab; McDowell, D. [Fermilab; Nicklaus, D. [Fermilab; Prieto, P. S. [Fermilab; Semenov, A. [Fermilab

    2016-10-12

    An interlock system has been designed for the Fermilab Cryo-module Test Stand (CMTS), a test bed for the cryo- modules to be used in the upcoming Linac Coherent Light Source 2 (LCLS-II) project at SLAC. The interlock system features 8 independent subsystems, one per superconducting RF cavity and solid state amplifier (SSA) pair. Each system monitors several devices to detect fault conditions such as arcing in the waveguides or quenching of the SRF system. Additionally each system can detect fault conditions by monitoring the RF power seen at the cavity coupler through a directional coupler. In the event of a fault condition, each system is capable of removing RF signal to the amplifier (via a fast RF switch) as well as turning off the SSA. Additionally, each input signal is available for re- mote viewing and recording via a Fermilab designed digitizer board and MVME 5500 processor.

  11. Signal interference RF photonic bandstop filter.

    Science.gov (United States)

    Aryanfar, Iman; Choudhary, Amol; Shahnia, Shayan; Pagani, Mattia; Liu, Yang; Marpaung, David; Eggleton, Benjamin J

    2016-06-27

    In the microwave domain, signal interference bandstop filters with high extinction and wide stopbands are achieved through destructive interference of two signals. Implementation of this filtering concept using RF photonics will lead to unique filters with high performance, enhanced tuning range and reconfigurability. Here we demonstrate an RF photonic signal interference filter, achieved through the combination of precise synthesis of stimulated Brillouin scattering (SBS) loss with advanced phase and amplitude tailoring of RF modulation sidebands. We achieve a square-shaped, 20-dB extinction RF photonic filter over a tunable bandwidth of up to 1 GHz with a central frequency tuning range of 16 GHz using a low SBS loss of ~3 dB. Wideband destructive interference in this novel filter leads to the decoupling of the filter suppression from its bandwidth and shape factor. This allows the creation of a filter with all-optimized qualities.

  12. RF accelerating unit installed in the PSB

    CERN Multimedia

    1972-01-01

    RF accelerating unit installed in the PSB ring between two bending magnets. Cool air from a heat exchanger is injected into the four cavities from the central feeder and the hot air recirculated via the lateral ducts.

  13. Si-based RF MEMS components.

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, James E.; Nordquist, Christopher Daniel; Baker, Michael Sean; Fleming, James Grant; Stewart, Harold D.; Dyck, Christopher William

    2005-01-01

    Radio frequency microelectromechanical systems (RF MEMS) are an enabling technology for next-generation communications and radar systems in both military and commercial sectors. RF MEMS-based reconfigurable circuits outperform solid-state circuits in terms of insertion loss, linearity, and static power consumption and are advantageous in applications where high signal power and nanosecond switching speeds are not required. We have demonstrated a number of RF MEMS switches on high-resistivity silicon (high-R Si) that were fabricated by leveraging the volume manufacturing processes available in the Microelectronics Development Laboratory (MDL), a Class-1, radiation-hardened CMOS manufacturing facility. We describe novel tungsten and aluminum-based processes, and present results of switches developed in each of these processes. Series and shunt ohmic switches and shunt capacitive switches were successfully demonstrated. The implications of fabricating on high-R Si and suggested future directions for developing low-loss RF MEMS-based circuits are also discussed.

  14. Design of RF Power System for CPHS

    Science.gov (United States)

    Cheng, Cheng; Du, Taibin; Guan, Xialing

    The Compact Pulsed Hadron Source (CPHS) system has been proposed and designed by the Department of Engineering Physics of Tsinghua University in Beijing, China. It consists of an accelerator front-end-a highintensity ion source, a 3 MeV radiofrequency quadrupole linac (RFQ), and a 13 MeV drift-tube linac (DTL), a neutron target station, and some experimental stations. In design of our RF power supply, both RFQ and DTL share a single klystron which is capable of 2.5 MW peak RF power and a 3.33% duty factor. The 325 MHz klystron contains a modulating anode and has a 100 kW average output power. Portions of the RF power system, such as pulsed high voltage power supply, modulator, crowbar protection and RF power transmission are all presented in details in this paper.

  15. RF/Optical Demonstration: Focal Plane Assembly

    Science.gov (United States)

    Hoppe, D. J.; Chung, S.; Kovalik, J.; Gama, E.; Fernandez, M. M.

    2016-11-01

    In this article, we describe the second-generation focal plane optical assembly employed in the RF/optical demonstration at DSS-13. This assembly receives reflected light from the two mirror segments mounted on the RF primary. The focal plane assembly contains a fast steering mirror (FSM) to stabilize the focal plane spot, a pupil camera to aid in aligning the two segments, and several additional cameras for receiving the optical signal prior to as well as after the FSM loop.

  16. RF waveguide phase-directed power combiners

    Energy Technology Data Exchange (ETDEWEB)

    Nantista, Christopher D.; Dolgashev, Valery A.; Tantawi, Sami G.

    2017-05-02

    High power RF phase-directed power combiners include magic H hybrid and/or superhybrid circuits oriented in orthogonal H-planes and connected using E-plane bends and/or twists to produce compact 3D waveguide circuits, including 8.times.8 and 16.times.16 combiners. Using phase control at the input ports, RF power can be directed to a single output port, enabling fast switching between output ports for applications such as multi-angle radiation therapy.

  17. Prototype storage cavity for LEP accelerating RF

    CERN Multimedia

    1980-01-01

    The principle of an RF storage cavity was demonstrated with this prototype, working at 500 MHz. Ian Wilso seems to hold it in his hands. The storage cavities had 4 portholes, 1 each for: RF feed; tuning; connection to the accelerating cavity; vacuum pump. The final storage cavities were larger, to suit the lower LEP accelerating frequency of 352.2 MHz. See also 8002294, 8006510X, 8109346, 8407619X, and Annual Report 1980, p.115.

  18. RF MEMS reconfigurable triangular patch antenna.

    Energy Technology Data Exchange (ETDEWEB)

    Christodoulou, Christos George (The University of New Mexico, Albuquerque, NM); Nordquist, Christopher Daniel; Feldner, Lucas Matthew

    2005-07-01

    A Ka-band RF MEMS enabled frequency reconfigurable triangular microstrip patch antenna has been designed for monolithic integration with RF MEMS phase shifters to demonstrate a low-cost monolithic passive electronically scanned array (PESA). This paper introduces our first prototype reconfigurable triangular patch antenna currently in fabrication. The aperture coupled patch antenna is fabricated on a dual-layer quartz/alumina substrate using surface micromachining techniques.

  19. RF MEMS reconfigurable triangular patch antenna.

    Energy Technology Data Exchange (ETDEWEB)

    Nordquist, Christopher Daniel; Christodoulou, Christos George (University of New Mexico, Albuquerque, NM); Feldner, Lucas Matthew

    2005-01-01

    A Ka-band RF MEMS enabled frequency reconfigurable triangular microstrip patch antenna has been designed for monolithic integration with RF MEMS phase shifters to demonstrate a low-cost monolithic passive electronically scanned array (PESA). This paper introduces our first prototype reconfigurable triangular patch antenna currently in fabrication. The aperture coupled patch antenna is fabricated on a dual-layer quartz/alumina substrate using surface micromachining techniques.

  20. RF study and 3-D simulations of a side-coupling thermionic RF-gun

    Science.gov (United States)

    Rimjaem, S.; Kusoljariyakul, K.; Thongbai, C.

    2014-02-01

    A thermionic RF-gun for generating ultra-short electron bunches was optimized, developed and used as a source at a linac-based THz radiation research laboratory of the Plasma and Beam Physics Research Facility, Chiang Mai University, Thailand. The RF-gun is a π/2-mode standing wave structure, which consists of two S-band accelerating cells and a side-coupling cavity. The 2856 MHz RF wave is supplied from an S-band klystron to the gun through the waveguide input-port at the cylindrical wall of the second cell. A fraction of the RF power is coupled from the second cell to the first one via a side-coupling cavity. Both the waveguide input-port and the side-coupling cavity lead to an asymmetric geometry of the gun. RF properties and electromagnetic field distributions inside the RF-gun were studied and numerically simulated by using computer codes SUPERFISH 7.19 and CST Microwave Studio 2012©. RF characterizations and tunings of the RF-gun were performed to ensure the reliability of the gun operation. The results from 3D simulations and measurements are compared and discussed in this paper. The influence of asymmetric field distributions inside the RF-gun on the electron beam properties was investigated via 3D beam dynamics simulations. A change in the coupling-plane of the side-coupling cavity is suggested to improve the gun performance.

  1. RF study and 3-D simulations of a side-coupling thermionic RF-gun

    Energy Technology Data Exchange (ETDEWEB)

    Rimjaem, S., E-mail: sakhorn.rimjaem@cmu.ac.th [Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Thailand Center of Excellence in Physics (ThEP), Commission on Higher Education, Bangkok 10400 (Thailand); Kusoljariyakul, K.; Thongbai, C. [Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200 (Thailand); Thailand Center of Excellence in Physics (ThEP), Commission on Higher Education, Bangkok 10400 (Thailand)

    2014-02-01

    A thermionic RF-gun for generating ultra-short electron bunches was optimized, developed and used as a source at a linac-based THz radiation research laboratory of the Plasma and Beam Physics Research Facility, Chiang Mai University, Thailand. The RF-gun is a π/2-mode standing wave structure, which consists of two S-band accelerating cells and a side-coupling cavity. The 2856 MHz RF wave is supplied from an S-band klystron to the gun through the waveguide input-port at the cylindrical wall of the second cell. A fraction of the RF power is coupled from the second cell to the first one via a side-coupling cavity. Both the waveguide input-port and the side-coupling cavity lead to an asymmetric geometry of the gun. RF properties and electromagnetic field distributions inside the RF-gun were studied and numerically simulated by using computer codes SUPERFISH 7.19 and CST Microwave Studio 2012{sup ©}. RF characterizations and tunings of the RF-gun were performed to ensure the reliability of the gun operation. The results from 3D simulations and measurements are compared and discussed in this paper. The influence of asymmetric field distributions inside the RF-gun on the electron beam properties was investigated via 3D beam dynamics simulations. A change in the coupling-plane of the side-coupling cavity is suggested to improve the gun performance.

  2. Overview of High Power Vacuum Dry RF Load Designs

    Energy Technology Data Exchange (ETDEWEB)

    Krasnykh, Anatoly [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-27

    A specific feature of RF linacs based on the pulsed traveling wave (TW) mode of operation is that only a portion of the RF energy is used for the beam acceleration. The residual RF energy has to be terminated into an RF load. Higher accelerating gradients require higher RF sources and RF loads, which can stably terminate the residual RF power. RF feeders (from the RF source though the accelerating section to the load) are vacuumed to transmit multi-megawatt high power RF. This overview will outline vacuumed RF loads only. A common method to terminate multi-MW RF power is to use circulated water (or other liquid) as an absorbing medium. A solid dielectric interface (a high quality ceramic) is required to separate vacuum and liquid RF absorber mediums. Using such RF load approaches in TW linacs is troubling because there is a fragile ceramic window barrier and a failure could become catastrophic for linac vacuum and RF systems. Traditional loads comprising of a ceramic disk have limited peak and average power handling capability and are therefore not suitable for high gradient TW linacs. This overview will focus on ''vacuum dry'' or ''all-metal'' loads that do not employ any dielectric interface between vacuum and absorber. The first prototype is an original design of RF loads for the Stanford Two-Mile Accelerator.

  3. Low reflectance high power RF load

    Energy Technology Data Exchange (ETDEWEB)

    Ives, R. Lawrence; Mizuhara, Yosuke M.

    2016-02-02

    A load for traveling microwave energy has an absorptive volume defined by cylindrical body enclosed by a first end cap and a second end cap. The first end cap has an aperture for the passage of an input waveguide with a rotating part that is coupled to a reflective mirror. The inner surfaces of the absorptive volume consist of a resistive material or are coated with a coating which absorbs a fraction of incident RF energy, and the remainder of the RF energy reflects. The angle of the reflector and end caps is selected such that reflected RF energy dissipates an increasing percentage of the remaining RF energy at each reflection, and the reflected RF energy which returns to the rotating mirror is directed to the back surface of the rotating reflector, and is not coupled to the input waveguide. Additionally, the reflector may have a surface which generates a more uniform power distribution function axially and laterally, to increase the power handling capability of the RF load. The input waveguide may be corrugated for HE11 mode input energy.

  4. Successful reconstruction of large oropharyngeal defect with pectoralis major myocutaneous flap in a four-year-old boy with recurrent fibromatosis

    Directory of Open Access Journals (Sweden)

    Yadav Prabha S

    2007-01-01

    Full Text Available Abstract Background Pectoralis major myocutaneous (PMMC flap continues to be the workhorse in head and neck reconstruction. Although free tissue transfer has revolutionized the reconstruction in cancers of the oral region, PMMC is still considered a readily accessible source of vascularized soft tissue available to the reconstructive surgeon and especially in most developing nations where due to the cost, time, expertise, or infrastructural constraints free flaps cannot be generally offered. Although commonly used in adults, it has been hardly described for reconstruction in children. Case presentation We present a 4-year-old child with recurrent fibromatosis of the oropharyngeal region where the PMMC was used for reconstruction of the surgical defect and to the best of our knowledge is the youngest patient undergoing reconstruction with PMMC for neoplastic lesion of the head and neck. Conclusion The PMMC flap is justifiably a popular flap that continues to command an important place in the head and neck surgeon's reconstructive armamentarium.

  5. Paniculite mesentérica (PM e fibromatose mesentérica (FM: relato de casos Mesenteric panniculitis (MP and mesenteric fibromatosis (MF: report of cases

    Directory of Open Access Journals (Sweden)

    Antônio Balestrim Filho

    2009-09-01

    Full Text Available A paniculite mesentérica (PM e a fibromatose mesentérica (FM são doenças fibróticas de etiologia incerta. São mais frequentes no mesentério do intestino delgado, no grande omento e nos mesocólons. Clinicamente a FM pode apresentar-se de forma aguda na qual uma complicação da doença é sua primeira expressão. Na forma crônica é caracterizada por sintomas abdominais vagos e/ou massa abdominal palpável. A comprovação diagnóstica, assim como na PM, é feita através de laparotomia exploradora ou videolaparoscopia diagnóstica e biopsia. Os autores relatam dois casos sendo um de PM e outro de FM, apresentam um paralelo dos aspectos clínicos, tomográficos, diagnóstico, histopatológico e terapêutico destacando as semelhanças e as diferenças entre essas duas patologias.Mesenteric panniculitis (MP and mesenteric fibromatosis (MF are fibrotic diseases of uncertain aetiology. Both occur most frequently in the mesentery of the small intestine, the greater omentum and the mesocolons. In its acute form, the first clinical symptoms of MF are complications of the disease. Chronic MF is characterized by vague abdominal symptoms and/or a palpable abdominal mass. Like mesenteric panniculitis, mesenteric fibromatosis can be diagnostically verified by exploratory laparotomy, or diagnostic video-laparoscopy and biopsy. Here, we present two cases, one of MP and the other of MF, with resembling clinical and tomographic aspects, as well as similarities in diagnosis, histopathology and therapy. With our case report, we want to emphasise both similarities and differences between these two pathologies.

  6. BRS 369RF and BRS 370RF: Glyphosate tolerant, high-yielding upland cotton cultivars for central Brazilian savanna

    Directory of Open Access Journals (Sweden)

    Camilo de Lelis Morello

    2015-12-01

    Full Text Available BRS 369RF and BRS 370RF were developed by the EMBRAPA as a part of efforts to create high-yielding germplasm with combinations of transgenic traits. BRS 369RF and BRS 370RF are midseason cultivars and have yield stability, adaptation to the central Brazilian savanna, good fiber quality and tolerance to glyphosate herbicide.

  7. RF pulse compression for future linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, P.B.

    1995-05-01

    Future (nonsuperconducting) linear colliders will require very high values of peak rf power per meter of accelerating structure. The role of rf pulse compression in producing this power is examined within the context of overall rf system design for three future colliders at energies of 1.0--1.5 TeV, 5 TeV and 25 TeV. In order keep the average AC input power and the length of the accelerator within reasonable limits, a collider in the 1.0--1.5 TeV energy range will probably be built at an x-band rf frequency, and will require a peak power on the order of 150--200 MW per meter of accelerating structure. A 5 TeV collider at 34 GHz with a reasonable length (35 km) and AC input power (225 MW) would require about 550 MW per meter of structure. Two-beam accelerators can achieve peak powers of this order by applying dc pulse compression techniques (induction linac modules) to produce the drive beam. Klystron-driven colliders achieve high peak power by a combination of dc pulse compression (modulators) and rf pulse compression, with about the same overall rf system efficiency (30--40%) as a two-beam collider. A high gain (6.8) three-stage binary pulse compression system with high efficiency (80%) is described, which (compared to a SLED-11 system) can be used to reduce the klystron peak power by about a factor of two, or alternately, to cut the number of klystrons in half for a 1.0--1.5 TeV x-band collider. For a 5 TeV klystron-driven collider, a high gain, high efficiency rf pulse compression system is essential.

  8. Pregnant women models analyzed for RF exposure and temperature increase in 3T RF shimmed birdcages.

    Science.gov (United States)

    Murbach, Manuel; Neufeld, Esra; Samaras, Theodoros; Córcoles, Juan; Robb, Fraser J; Kainz, Wolfgang; Kuster, Niels

    2017-05-01

    MRI is increasingly used to scan pregnant patients. We investigated the effect of 3 Tesla (T) two-port radiofrequency (RF) shimming in anatomical pregnant women models. RF shimming improves B1(+) uniformity, but may at the same time significantly alter the induced current distribution and result in large changes in both the level and location of the absorbed RF energy. In this study, we evaluated the electrothermal exposure of pregnant women in the third, seventh, and ninth month of gestation at various imaging landmarks in RF body coils, including modes with RF shimming. Although RF shimmed configurations may lower the local RF exposure for the mother, they can increase the thermal load on the fetus. In worst-case configurations, whole-body exposure and local peak temperatures-up to 40.8°C-are equal in fetus and mother. Two-port RF shimming can significantly increase the fetal exposure in pregnant women, requiring further research to derive a very robust safety management. For the time being, restriction to the CP mode, which reduces fetal SAR exposure compared with linear-horizontal polarization modes, may be advisable. Results from this study do not support scanning pregnant patients above the normal operating mode. Magn Reson Med 77:2048-2056, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  9. RF MEMS的关键技术与器件%Key Technology and Devices of RF MEMS

    Institute of Scientific and Technical Information of China (English)

    夏牟; 郝达兵

    2006-01-01

    文章介绍了RF MEMS的基本概念、基本特征与关键工艺技术.文章在介绍了RF-MEMS元器件的基础上,对RF MEMS与MMIC进行了比较,分析了RF MEMS需解决的重点问题.最后对RF MEMS的发展前景进行了展望.

  10. RF characterization and testing of ridge waveguide transitions for RF power couplers

    Science.gov (United States)

    Kumar, Rajesh; Jose, Mentes; Singh, G. N.; Kumar, Girish; Bhagwat, P. V.

    2016-12-01

    RF characterization of rectangular to ridge waveguide transitions for RF power couplers has been carried out by connecting them back to back. Rectangular waveguide to N type adapters are first calibrated by TRL method and then used for RF measurements. Detailed information is obtained about their RF behavior by measurements and full wave simulations. It is shown that the two transitions can be characterized and tuned for required return loss at design frequency of 352.2 MHz. This opens the possibility of testing and conditioning two transitions together on a test bench. Finally, a RF coupler based on these transitions is coupled to an accelerator cavity. The power coupler is successfully tested up to 200 kW, 352.2 MHz with 0.2% duty cycle.

  11. RF BREAKDOWN STUDIES USING PRESSURIZED CAVITIES

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland

    2014-09-21

    Many present and future particle accelerators are limited by the maximum electric gradient and peak surface fields that can be realized in RF cavities. Despite considerable effort, a comprehensive theory of RF breakdown has not been achieved and mitigation techniques to improve practical maximum accelerating gradients have had only limited success. Part of the problem is that RF breakdown in an evacuated cavity involves a complex mixture of effects, which include the geometry, metallurgy, and surface preparation of the accelerating structures and the make-up and pressure of the residual gas in which plasmas form. Studies showed that high gradients can be achieved quickly in 805 MHz RF cavities pressurized with dense hydrogen gas, as needed for muon cooling channels, without the need for long conditioning times, even in the presence of strong external magnetic fields. This positive result was expected because the dense gas can practically eliminate dark currents and multipacting. In this project we used this high pressure technique to suppress effects of residual vacuum and geometry that are found in evacuated cavities in order to isolate and study the role of the metallic surfaces in RF cavity breakdown as a function of magnetic field, frequency, and surface preparation. One of the interesting and useful outcomes of this project was the unanticipated collaborations with LANL and Fermilab that led to new insights as to the operation of evacuated normal-conducting RF cavities in high external magnetic fields. Other accomplishments included: (1) RF breakdown experiments to test the effects of SF6 dopant in H2 and He gases with Sn, Al, and Cu electrodes were carried out in an 805 MHz cavity and compared to calculations and computer simulations. The heavy corrosion caused by the SF6 components led to the suggestion that a small admixture of oxygen, instead of SF6, to the hydrogen would allow the same advantages without the corrosion in a practical muon beam line. (2) A

  12. Scintigraphic evaluation of soft tissue tumors with technetium(V)-99m dimercaptosuccinic acid, a new tumor seeking radiopharmaceutical

    Energy Technology Data Exchange (ETDEWEB)

    Ohta, H.; Yoshizumi, M.; Endo, K.; Torizuka, K.; Yokoyama, A.; Yamamoto, K.

    1984-01-01

    Recently, a very promising tumor seeking agent, a Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS), which was labelled under optimal pH 8 and very low SnCl/sub 2/ concentrations, has been developed. An equilibrium between a stable form and a dissociated form of anion TcO/sub 4//sup 3-/, structural similarity to PO/sub 4//sup 3-/, postulated for tumor uptake. And the authors have previously reported that Tc(V)-DMS scintigram would be useful in the diagnosis of medullary thyroid carcinoma. In an attempt to widen its applicability, the scintigraphic examinations of soft tissue tumors with Tc(V)-DMS and comparative study with Ga-67 citrate were performed in 58 patients. Scintigrams were made 60-120 min after i.v. administration of 10 mCi Tc(V)-DMS using a conventional gamma camera. Tc(V)-DMS was found to have superior sensitivity of 90% for malignant tumors (including aggressive fibromatosis) to that with Ga-67 citrate of 56%, but inferior specificity of 71% to that with Ga-67 citrate of 80%. And the accuracy of the scan in soft tissue tumors with Tc(V)-DMS and Ga-67 citrate was 78% and 71%, respectively. Although the accumulation of Tc(V)-DMS has been detected in some benign soft tissue tumors and the exact mechanism of Tc(V)-DMS accumulation remains to be elucidated, these data indicated that Tc(V)-DMS scintigraphy would be of great use in the detection of extension or location of malignant soft tissue tumors.

  13. Investigation of MIM Diodes for RF Applications

    KAUST Repository

    Khan, Adnan

    2015-05-01

    Metal Insulator Metal (MIM) diodes that work on fast mechanism of tunneling have been used in a number of very high frequency applications such as (Infra-Red) IR detectors and optical Rectennas for energy harvesting. Their ability to operate under zero bias condition as well as the possibility of realizing them through printing makes them attractive for (Radio Frequency) RF applications. However, MIM diodes have not been explored much for RF applications. One reason preventing their widespread RF use is the requirement of a very thin oxide layer essential for the tunneling operation that requires sophisticated nano-fabrication processes. Another issue is that the reliability and stable performance of MIM diodes is highly dependent on the surface roughness of the metallic electrodes. Finally, comprehensive RF characterization has not been performed for MIM diodes reported in the literature, particularly from the perspective of their integration with antennas as well as their rectification abilities. In this thesis, various metal deposition methods such as sputtering, electron beam evaporation, and Atomic Layer Deposition (ALD) are compared in pursuit of achieving low surface roughness. It is worth mentioning here that MIM diodes realized through ALD method have been presented for the first time in this thesis. Amorphous metal alloy have also been investigated in terms of their low surface roughness. Zinc-oxide has been investigated for its suitability as a thin dielectric layer for MIM diodes. Finally, comprehensive RF characterization of MIM diodes has been performed in two ways: 1) by standard S-parameter methods, and 2) by investigating their rectification ability under zero bias operation. It is concluded from the Atomic Force Microscopy (AFM) imaging that surface roughness as low as sub 1 nm can be achieved reliably from crystalline metals such as copper and platinum. This value is comparable to surface roughness achieved from amorphous alloys, which are non

  14. Focusing properties of discrete RF quadrupoles

    Science.gov (United States)

    Li, Zhi-Hui; Wang, Zhi-Jun

    2017-08-01

    The particle motion equation for a Radio Frequency (RF) quadrupole is derived. The motion equation shows that the general transform matrix of a RF quadrupole with length less than or equal to 0.5βλ (β is the relativistic velocity of particles and λ is wavelength of radio frequency electromagnetic field) can describe the particle motion in an arbitrarily long RF quadrupole. By iterative integration, the general transform matrix of a discrete RF quadrupole is derived from the motion equation. The transform matrix is in form of a power series of focusing parameter B. It shows that for length less than βλ, the series up to the 2nd order of B agrees well with the direct integration results for B up to 30, while for length less than 0.5βλ, the series up to 1st order is already a good approximation of the real solution for B less than 30. The formula of the transform matrix can be integrated into linac or beam line design code to deal with the focusing of discrete RF quadrupoles. Supported by National Natural Science Foundation of China (11375122, 11511140277) and Strategic Priority Research Program of the Chinese Academy of Sciences (XDA03020705)

  15. The CEBAF RF Separator System Upgrade

    CERN Document Server

    Hovater, C; Guerra, A; Nelson, R; Terrel, R A; Wissmann, M

    2004-01-01

    The CEBAF accelerator uses RF deflecting cavities operating at the third sub-harmonic (499 MHz) of the accelerating frequency (1497 MHz) to “kick” the electron beam to the experimental halls. The cavities operate in a TEM dipole mode incorporating mode enhancing rods to increase the cavity’s transverse shunt impedance. As the accelerators energy has increased from 4 GeV to 6 GeV the RF system, specifically the 1 kW solid state amplifiers, have become problematic, operating in saturation because of the increased beam energy demands. Two years ago we began a study to look into replacement for the RF amplifiers and decided to use a commercial broadcast Inductive Output Tube (IOT) capable of 30 kW. The new RF system uses one IOT amplifier on multiple cavities as opposed to one amplifier per cavity originally. In addition the new RF system supports the proposed 12 GeV energy upgrade to CEBAF. Currently we are halfway through the upgrade with two IOTs in operation and two more to be in...

  16. Rf Station For Ion Beam Staking In Hirfl-csr

    CERN Document Server

    Arbuzov, V S; Bushuev, A A; Dranichnikov, A N; Gorniker, E I; Kendjebulatov, E K; Kondakov, A A; Kondaurov, M; Kruchkov, Ya G; Krutikhin, S A; Kurkin, G Ya; Mironenko, L A; Motygin, S V; Osipov, V N; Petrov, V M; Pilan, Andrey M; Popov, A M; Rashenko, V V; Selivanov, A N; Shteinke, A R; Vajenin, N F

    2004-01-01

    BINP has developed and produced the RF station for Institute of Modern Physics (IMP), Lanzhou, China, for multipurpose accelerator complex with electron cooling. The RF station will be used for accumulation of ion beams in the main ring of the system. It was successfully tested in IMP and installed into the main accelerator ring of the complex. The RF station includes accelerating RF cavity and RF power generator with power supplies. The station works within frequency range 6.0 - 14.0 MHz, maximum voltage across the accelerating gap of the RF cavity - 20 kV. In the RF cavity the 200 VNP ferrite is utilized. A residual gas pressure in vacuum chamber does not exceed 2,5E-11 mbar. Maximum output power of the RF generator 25 kW. The data acquisition and control of the RF station is based on COMPACT - PCI bus and provides all functions of monitoring and control.

  17. Wilms Tumor

    Science.gov (United States)

    Wilms tumor is a rare type of kidney cancer. It causes a tumor on one or both kidneys. It usually affects ... are at risk should be screened for Wilms tumor every three months until they turn eight. Symptoms ...

  18. An unusual case of fatty liver in a patient with desmoid tumor

    Institute of Scientific and Technical Information of China (English)

    Francesca De Felice; Daniela Musio; Rossella Caiazzo; Bartolomeo Dipalma; Lavinia Grapulin; Camilla Proietti Semproni; Vincenzo Tombolini

    2012-01-01

    A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic tissues.It can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and retroperitoneum.The typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous structures.It is associated with a high local recurrence rate after resection.Many issues regarding the optimal treatment of desmoid tumors remain controversial.Aggressive surgical resection with a wide margin (2-3 cm) remains the gold standard treatment with regard to preserving quality of life.Radiotherapy alone has been shown to be effective for the control of unresectable or recurrent lesions.Desmoid tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal recurrence.The radiation dose appropriate for treating desmoid tumors remains controversial.We present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with radiotherapy.The patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of life.The patient developed short bowel syndrome as a complication of second surgical resection.Consequently,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis.

  19. RF-Photonic Frequency Stability Gear Box

    CERN Document Server

    Matsko, Andrey B; Ilchenko, Vladimir S; Seidel, David; Maleki, Lute

    2011-01-01

    An optical technique based on stability transfer among modes of a monolithic optical microresonator is proposed for long therm frequency stabilization of a radiofrequency (RF) oscillator. We show that locking two resonator modes, characterized with dissimilar sensitivity in responding to an applied forcing function, to a master RF oscillator allows enhancing the long term stability of a slave RF oscillator locked to two resonator modes having nearly identical sensitivity. For instance, the stability of a 10 MHz master oscillator characterized with Allan deviation of 10^-7 at 10^4s can be increased and transferred to a slave oscillator with identical stability performance, so that the resultant Allan deviation of the slave oscillator becomes equal to 10-13 at 10^4s. The method does not require absolute frequency references to achieve such a performance.

  20. Nanocavity optomechanical torque magnetometry and RF susceptometry

    CERN Document Server

    Wu, Marcelo; Firdous, Tayyaba; Sani, Fatemeh Fani; Losby, Joseph E; Freeman, Mark R; Barclay, Paul E

    2016-01-01

    Nanophotonic optomechanical devices allow observation of nanoscale vibrations with sensitivity that has dramatically advanced metrology of nanomechanical structures [1-9] and has the potential to similarly impact studies of nanoscale physical systems [10, 11]. Here we demonstrate this potential with a nanophotonic optomechanical torque magnetometer and radio-frequency (RF) magnetic susceptometer. Exquisite readout sensitivity provided by a nanocavity integrated within a torsional nanomechanical resonator enables observations of the unique net magnetization and RF driven responses of single mesoscopic magnetic structures in ambient conditions. The magnetic moment resolution is sufficient for observation of Barkhausen steps in the magnetic hysteresis of a lithographically-patterned permalloy island [12]. In addition, significantly enhanced RF susceptibility is found over narrow field ranges and attributed to thermally-assisted driven hopping of a magnetic vortex core between neighboring pinning sites [13]. The ...

  1. A two-Frequency RF Photocathode Gun

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, D.H. E-mail: dowell@slac.stanford.edu; Ferrario, M.; Kimura, T.; Lewellen, J.; Limborg, C.; Raimondi, P.; Schmerge, J.F.; Serafini, L.; Smith, T.; Young, L

    2004-08-01

    In this paper we resurrect an idea originally proposed by Serafini (Nucl. Instr. and Meth. A 318 (1992) 301) in 1992 for an RF photocathode gun capable of operating simultaneously at the fundamental frequency and a higher frequency harmonic. Driving the gun at two frequencies with the proper field ratio and relative phase produces a beam with essentially no RF emittance and a linear longitudinal phase space distribution. Such a gun allows a completely new range of operating parameters for controlling space charge emittance growth. In addition, the linear longitudinal phase space distribution aids in bunch compression. This paper will compare results of simulations for the two-frequency gun with the standard RF gun and the unique properties of the two-frequency gun will be discussed.

  2. Investigation of RF Signal Energy Harvesting

    Directory of Open Access Journals (Sweden)

    Soudeh Heydari Nasab

    2010-01-01

    Full Text Available The potential utilization of RF signals for DC power is experimentally investigated. The aim of the work is to investigate the levels of power that can be harvested from the air and processed to achieve levels of energy that are sufficient to charge up low-power electronic circuits. The work presented shows field measurements from two selected regions: an urbanized hence signal congested area and a less populated one. An RF harvesting system has been specifically designed, built, and shown to successfully pick up enough energy to power up circuits. The work concludes that while RF harvesting was successful under certain conditions, however, it required the support of other energy harvesting techniques to replace a battery. Efficiency considerations have, hence, placed emphasis on comparing the developed harvester to other systems.

  3. Directions for rf-controlled intelligent microvalve

    Science.gov (United States)

    Enderling, Stefan; Varadan, Vijay K.; Abbott, Derek

    2001-03-01

    In this paper, we consider the novel concept of a Radio Frequency (RF) controllable microvalve for different medical applications. Wireless communication via a Surface Acoustic Wave Identification-mark (SAW ID-tag) is used to control, drive and locate the microvalve inside the human body. The energy required for these functions is provided by RF pulses, which are transmitted to the valve and back by a reader/transmitter system outside of the body. These RF bursts are converted into Surface Acoustic Waves (SAWs), which propagate along the piezoelectric actuator material of the microvalve. These waves cause deflections, which are employed to open and close the microvalve. We identified five important areas of application of the microvalve in biomedicine: 1) fertility control; 2) artificial venous valves; 3) flow cytometry; 4) drug delivery and 5) DNA mapping.

  4. Photonic technology for switched rf avionics networks

    Science.gov (United States)

    Hamilton, Michael C.; Thaniyavarn, Suwat; Abbas, Gregory L.; LaGasse, Michael J.; Traynor, Timothy; Lin, Jack P.

    1997-10-01

    The application of photonics technology in switched RF networks is discussed with emphasis on the benefits for avionics applications. System requirements and performance issues are addressed. A 16 X 16 photonic switch module prototype is described and results for RF fiber-optic links passing through the module are presented. RF channel isolation measured was at least 75 dB. A demonstration is described in which a photonic network using the switch module passed signals from a dynamic electromagnetic environment simulator to two radar warning systems under test. Demonstration modes included simulation of both aperture sharing and processor sharing. Finally, a novel alternative switch module architecture is described that is strictly non-blocking and has inherently better channel isolation.

  5. RF Electron Gun with Driven Plasma Cathode

    CERN Document Server

    Khodak, Igor

    2005-01-01

    It's known that RF guns with plasma cathodes based on solid-state dielectrics are able to generate an intense electron beam. In this paper we describe results of experimental investigation of the single cavity S-band RF gun with driven plasma cathode. The experimental sample of the cathode based on ferroelectric ceramics has been designed. Special design of the cathode permits to separate spatially processes of plasma development and electron acceleration. It has been obtained at RF gun output electron beam with particle energy ~500 keV, pulse current of 4 A and pulse duration of 80 ns. Results of experimental study of beam parameters are referred in. The gun is purposed to be applied as the intense electron beam source for electron linacs.

  6. The CLICopti RF structure parameter estimator

    CERN Document Server

    Sjobak, Kyrre Ness

    2014-01-01

    This document describes the CLICopti RF structure parameter estimator. This is a C++ library which makes it possible to quickly estimate the parameters of an RF structure from its length, apertures, tapering, and basic cell type. Typical estimated parameters are the input power required to reach a certain voltage with a given beam current, the maximum safe pulse length for a given input power and the minimum bunch spacing in RF cycles allowed by a given long-range wake limit. The document describes the implemented physics, usage of the library through its Application Programming Interface (API) and the relation between the different parts of the library. Also discussed is how the library is checked for correctness, and the example programs included with the sources are described.

  7. A Two-Frequency RF Photocathode Gun

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, D.

    2004-11-05

    In this paper we resurrect an idea originally proposed by Serafini[1] in 1992 for an RF photocathode gun capable of operating simultaneously at the fundamental frequency and a higher frequency harmonic. Driving the gun at two frequencies with the proper field ratio and relative phase produces a beam with essentially no rf emittance and a linear longitudinal phase space distribution. Such a gun allows a completely new range of operating parameters for controlling space charge emittance growth. In addition, the linear longitudinal phase space distribution aids in bunch compression. This paper will compare results of simulations for the two-frequency gun with the standard rf gun, and the unique properties of the two-frequency gun will be discussed.

  8. Computational Tools for RF Structure Design

    CERN Document Server

    Jensen, E

    2004-01-01

    The Finite Differences Method and the Finite Element Method are the two principally employed numerical methods in modern RF field simulation programs. The basic ideas behind these methods are explained, with regard to available simulation programs. We then go through a list of characteristic parameters of RF structures, explaining how they can be calculated using these tools. With the help of these parameters, we introduce the frequency-domain and the time-domain calculations, leading to impedances and wake-fields, respectively. Subsequently, we present some readily available computer programs, which are in use for RF structure design, stressing their distinctive features and limitations. One final example benchmarks the precision of different codes for calculating the eigenfrequency and Q of a simple cavity resonator.

  9. Fabrication and Testing of RF Structures

    CERN Document Server

    Jensen, E

    2004-01-01

    Modern RF structures make great demands on both materials and fabrication techniques. In addition to high required precision, they need to be compatible with ultra high vacuum, high power RF and the presence of particle beams. We introduce materials compatible with these demands and summarize their relevant characteristics. Methods of forming and joining follow, again with emphasis on those suited for the fabrication of accelerating structures, and we point out their limitations. We mention different tests which will be designed into the fabrication process, and describe in some detail the testing of the RF properties of accelerating structures. The following overview is non-exhaustive and limited to normal-conducting structures; many of the examples relate to a possible next-generation linear collider.

  10. Source of spill ripple in the RF-KO slow-extraction method with FM and AM

    Science.gov (United States)

    Noda, K.; Furukawa, T.; Shibuya, S.; Muramatsu, M.; Uesugi, T.; Kanazawa, M.; Torikoshi, M.; Takada, E.; Yamada, S.

    2002-10-01

    The RF-knockout (RF-KO) slow-extraction method with frequency modulation (FM) and amplitude modulation (AM) has brought high-accuracy irradiation to the treatment of a cancer tumor moving with respiration, because of a quick response to beam start/stop. However, a beam spill extracted from a synchrotron ring through RF-KO slow-extraction has a huge ripple with a frequency of around 1 kHz related to the FM. The spill ripple will disturb the lateral dose distribution in the beam scanning methods. Thus, the source of the spill ripple has been investigated through experiments and simulations. There are two tune regions for the extraction process through the RF-KO method: the extraction region and the diffusion region. The particles in the extraction region can be extracted due to amplitude growth through the transverse RF field, only when its frequency matches with the tune in the extraction region. For a large chromaticity, however, the particles in the extraction region can be extracted through the synchrotron oscillation, even when the frequency does not match with the tune in the extraction region. Thus, the spill structure during one period of the FM strongly depends on the horizontal chromaticity. They are repeated with the repetition frequency of the FM, which is the very source of the spill ripple in the RF-KO method.

  11. Rf-inhomogeneity compensation using method of Fourier synthesis

    Science.gov (United States)

    Khaneja, Navin

    2017-04-01

    In this paper, we propose a new method for design of composite pulses that are robust to rf-amplitude (rf-inhomogeneity). We call this, the method of Fourier synthesis. The method is general enough to design excitation, inversion, refocusing or arbitary flip angle pulses that are robust to rf-amplitude. The method can be tailored to have amplitude selective excitation. We experimentally show rf-compensation over a order of magnitude (20 db) variation in rf-amplitude. The method is expected to find use in invivo NMR studies using surface coils, where there is large dispersion in rf-amplitude over the sample.

  12. Design of an L-band normally conducting RF gun cavity for high peak and average RF power

    Science.gov (United States)

    Paramonov, V.; Philipp, S.; Rybakov, I.; Skassyrskaya, A.; Stephan, F.

    2017-05-01

    To provide high quality electron bunches for linear accelerators used in free electron lasers and particle colliders, RF gun cavities operate with extreme electric fields, resulting in a high pulsed RF power. The main L-band superconducting linacs of such facilities also require a long RF pulse length, resulting in a high average dissipated RF power in the gun cavity. The newly developed cavity based on the proven advantages of the existing DESY RF gun cavities, underwent significant changes. The shape of the cells is optimized to reduce the maximal surface electric field and RF loss power. Furthermore, the cavity is equipped with an RF probe to measure the field amplitude and phase. The elaborated cooling circuit design results in a lower temperature rise on the cavity RF surface and permits higher dissipated RF power. The paper presents the main solutions and results of the cavity design.

  13. RF Driven Multicusp H- Ion Source

    Energy Technology Data Exchange (ETDEWEB)

    Leung, K.N.; DeVries, G.J.; DiVergilio, W.F.; Hamm, R.W.; Hauck, C.A.; Kunkel, W.B.; McDonald, D.S.; Williams, M.D.

    1990-06-01

    An rf driven multicusp source capable of generating 1-ms H{sup -} beam pulses with a repetition rate as high as 150 Hz has been developed. This source can be operated with a filament or other types of starter. There is almost no lifetime limitation and a clean plasma can be maintained for a long period of operation. It is demonstrated that rf power as high as 25 kW could be coupled inductively to the plasma via a glass-coated copper-coil antenna. The extracted H{sup -} current density achieved is about 200 mA/cm{sup 2}.

  14. Coherent oscillations of driven rf SQUID metamaterials.

    Science.gov (United States)

    Trepanier, Melissa; Zhang, Daimeng; Mukhanov, Oleg; Koshelets, V P; Jung, Philipp; Butz, Susanne; Ott, Edward; Antonsen, Thomas M; Ustinov, Alexey V; Anlage, Steven M

    2017-05-01

    Through experiments and numerical simulations we explore the behavior of rf SQUID (radio frequency superconducting quantum interference device) metamaterials, which show extreme tunability and nonlinearity. The emergent electromagnetic properties of this metamaterial are sensitive to the degree of coherent response of the driven interacting SQUIDs. Coherence suffers in the presence of disorder, which is experimentally found to be mainly due to a dc flux gradient. We demonstrate methods to recover the coherence, specifically by varying the coupling between the SQUID meta-atoms and increasing the temperature or the amplitude of the applied rf flux.

  15. Lumped elements for RF and microwave circuits

    CERN Document Server

    Bahl, Inder

    2003-01-01

    Due to the unprecedented growth in wireless applications over the past decade, development of low-cost solutions for RF and microwave communication systems has become of great importance. This practical new book is the first comprehensive treatment of lumped elements, which are playing a critical role in the development of the circuits that make these cost-effective systems possible. The books offers you an in-depth understanding of the different types of RF and microwave circuit elements, including inductors, capacitors, resistors, transformers, via holes, airbridges, and crossovers. Support

  16. Inductance of rf-wave-heated plasmas.

    Science.gov (United States)

    Farshi, E; Todo, Y

    2003-03-14

    The inductance of rf-wave-heated plasmas is derived. This inductance represents the inductance of fast electrons located in a plateau during their acceleration due to electric field or deceleration due to collisions and electric field. This inductance has been calculated for small electric fields from the two-dimensional Fokker-Planck equation as the flux crossing the surface of critical energy mv(2)(ph)/2 in the velocity space. The new expression may be important for radio-frequency current drive ramp-up, current drive efficiency, current profile control, and so on in tokamaks. This inductance may be incorporated into transport codes that study plasma heating by rf waves.

  17. RF MEMS theory, design, and technology

    CERN Document Server

    Rebeiz, Gabriel M

    2003-01-01

    Ultrasmall Radio Frequency and Micro-wave Microelectromechanical systems (RF MEMs), such as switches, varactors, and phase shifters, exhibit nearly zero power consumption or loss. For this reason, they are being developed intensively by corporations worldwide for use in telecommunications equipment. This book acquaints readers with the basics of RF MEMs and describes how to design practical circuits and devices with them. The author, an acknowledged expert in the field, presents a range of real-world applications and shares many valuable tricks of the trade.

  18. RF installation for the grain disinfestation

    CERN Document Server

    Zajtzev, B V; Kobetz, A F; Rudiak, B I

    2001-01-01

    The ecologically pure method of grain product disinfestations through the grain treatment with the RF electric field is described. The experimental data obtained showed that with strengths of the electrical RF field of E=5 kV/cm and frequency of 80 MHz the relative death rate is 100%.The time of the grain treatment it this case is 1 sec. The pulses with a duration of 600 mu s and repetition rate of 2 Hz were used, the duration of the front was 10 mu s. The schematic layout of installation with a productivity of 50 tones/h and power of 10 kW is given.

  19. Initial measurements of the UCLA rf photoinjector

    Science.gov (United States)

    Hartman, S. C.; Barov, N.; Pellegrini, C.; Park, S.; Rosenzweig, J.; Travish, G.; Zhang, R.; Clayton, C.; Davis, P.; Everett, M.; Joshi, C.; Hairapetian, G.

    1994-02-01

    The 1.5 cell standing wave rf photoinjector has been operated for the past several months using a copper cathode. The photoinjector drive laser produces sub 2 ps pulses of UV (λ = 266 nm) light with up to 200 μJ/pulse which generates up to 3 nC of charge. The emittance of the photoinjector was measured as a function of charge, rf launching phase, and peak accelerating field. Also, the quantum efficiency and pulse lengths of the laser beam and the electron beam were measured.

  20. Fundamentals of RF and microwave transistor amplifiers

    CERN Document Server

    Bahl, Inder J

    2009-01-01

    A Comprehensive and Up-to-Date Treatment of RF and Microwave Transistor Amplifiers This book provides state-of-the-art coverage of RF and microwave transistor amplifiers, including low-noise, narrowband, broadband, linear, high-power, high-efficiency, and high-voltage. Topics covered include modeling, analysis, design, packaging, and thermal and fabrication considerations. Through a unique integration of theory and practice, readers will learn to solve amplifier-related design problems ranging from matching networks to biasing and stability. More than 240 problems are included to help read

  1. RF Circuit Design in Nanometer CMOS

    OpenAIRE

    Nauta, Bram

    2007-01-01

    With CMOS technology entering the nanometer regime, the design of analog and RF circuits is complicated by low supply voltages, very non-linear (and nonquadratic) devices and large 1/f noise. At the same time, circuits are required to operate over increasingly wide bandwidths to implement modern multi-band communication systems as these systems move toward software-defined radio. These trends in technology and system design call for a re-thinking of analog and RF circuit design in nanometer C...

  2. Emittance investigation of RF photo-injector

    CERN Document Server

    Yang Mao Rong; Li Zheng; Li Ming; Xu Zhou

    2002-01-01

    A high-power laser beam illuminates a photocathode surface placed on an end wall of an RF cavity. The emitted electrons are accelerated immediately to a relativistic energy by the strong RF find in the cavity. But space charge effect induces beam emittance growth especially near the cathode where the electrons are still nonrelativistic. The author analyzes the factors which lead the transverse emittance growth and method how to resolve this problem. After introducing solenoidal focusing near the photocathode, the beam emittance growth is suppressed dramatically. The beam emittance is given also after compensation and simulation results. The measurements show these results are coincident

  3. RF-thermal-structural-RF coupled analysis on a travelling wave disk-loaded accelerating structure

    Institute of Scientific and Technical Information of China (English)

    PEI Shi-Lun; CHI Yun-Long; ZHANG Jing-Ru; HOU Mi; LI Xiao-Ping

    2012-01-01

    The travelling wave (TW) disk-loaded accelerating structure is one of the key components in normal conducting (NC) linear accelerators,and has been studied for many years.In the design process,usually after the dimensions of each cell and the two couplers are finalized,the structure is fabricated and tuned,and then the whole structure RF characteristics are measured by using a vector network analyzer.Before fabrication,the whole structure characteristics (including RF,thermal and structural ones) are less simulated due to the limited capability of currently available computers.In this paper,we described a method for performing RF-thermal-structural-RF coupled analysis on a TW disk-loaded structure using only one PC.In order to validate our method,we first analyzed and compared our RF simulation results on the 3 m long BEPC Ⅱ structure with the corresponding experimental results,which shows very good consistency.Finally,the RF-thermal-structure-RF coupled analysis results on the 1.35 m long NSC KIPT linac accelerating structure are presented.

  4. Expression of annexin Ⅱ, TGF-β1 and TGF-βRI in desmoid-type fibromatosis%韧带样型纤维瘤病中Annexin Ⅱ、TGF-β1和TGF-βRI的表达

    Institute of Scientific and Technical Information of China (English)

    苗亚静; 宋魏; 李家印; 仇晓菲

    2013-01-01

    Purpose To investigate the expression of annexin Ⅱ , TGF-p, and TGF-βRI, and their possible roles in desmoid-type fibromatosis ( DTF ). Methods The expression of annexin II , TGF-p, and TGF-βRI was detected in 34 DTF tumors and matched surrounding tissues by immunohistochemical staining. Results Annexin Ⅱ was expressed in 29 of 34 cases ( 85. 3% ) of DTF, which were significantly higher than that of surrounding tissues ( P < 0. 05 ). The positive tumor cells were mainly distributed in infiltrating region. The average percentage of annexin Ⅱ positive cells in DTF was significantly higher than that of surrounding tissues ( P < 0. 05 ), and that in infiltrating areas was significantly higher than that in non-infiltrated ones ( P < 0. 05 ). The positive expression rates of TGF-β1, and TGF-βRI in DTF were 79. 4% ( 27/34 ) and 82. 4% ( 28/34 ), respectively, which were remarkably higher than those of surrounding tissues ( P <0. 05 ). The expression of TGF-pRI was positively correlated with TGF-β1( P <0. 05 ). Conclusions Annexin Ⅱ may participate in the development of DTF and the infiltrative growth of tumor cells, and may be a potential target for anti-DTF therapy. In addition, there may be existed a TGF-p, autocrine loops in DTF.%目的 探讨Annexin Ⅱ、TGF-β1和TGF-βRI在韧带样型纤维瘤病(desmoid-type fibromatosis,DTF)组织中的表达及意义.方法 采用免疫组化PV-9000两步法检测34例DTF和周围正常组织中Annexin Ⅱ、TGF-β1和TGF-βRI的表达及分布.结果 (1)Annexin Ⅱ在DTF中的阳性率为85.3%(29/34),明显高于周围正常组织(P<0.05),阳性表达在浸润区尤为突出.Annexin Ⅱ在DTF中的平均阳性细胞率明显高于周围组织(P<0.05);在浸润区平均阳性细胞率明显高于非浸润区(P<0.05).(2)DTF肿瘤组织中TGF-β1和TGF-βRI的阳性率分别为79.4%(27/34)和82.4%(28/34),明显高于周围正常组织(P<0.05);TGF-β1与TGF-βRI表达呈正相关(P<0.05).结论 (1)Annexin Ⅱ可能

  5. Cryoelectron Microscopic Structures of Eukaryotic Translation Termination Complexes Containing eRF1-eRF3 or eRF1-ABCE1

    Directory of Open Access Journals (Sweden)

    Anne Preis

    2014-07-01

    Full Text Available Termination and ribosome recycling are essential processes in translation. In eukaryotes, a stop codon in the ribosomal A site is decoded by a ternary complex consisting of release factors eRF1 and guanosine triphosphate (GTP-bound eRF3. After GTP hydrolysis, eRF3 dissociates, and ABCE1 can bind to eRF1-loaded ribosomes to stimulate peptide release and ribosomal subunit dissociation. Here, we present cryoelectron microscopic (cryo-EM structures of a pretermination complex containing eRF1-eRF3 and a termination/prerecycling complex containing eRF1-ABCE1. eRF1 undergoes drastic conformational changes: its central domain harboring the catalytically important GGQ loop is either packed against eRF3 or swung toward the peptidyl transferase center when bound to ABCE1. Additionally, in complex with eRF3, the N-terminal domain of eRF1 positions the conserved NIKS motif proximal to the stop codon, supporting its suggested role in decoding, yet it appears to be delocalized in the presence of ABCE1. These results suggest that stop codon decoding and peptide release can be uncoupled during termination.

  6. Simulations of S-band RF gun with RF beam control

    Science.gov (United States)

    Barnyakov, A. M.; Levichev, A. E.; Maltseva, M. V.; Nikiforov, D. A.

    2017-08-01

    The RF gun with RF control is discussed. It is based on the RF triode and two kinds of the cavities. The first cavity is a coaxial cavity with cathode-grid assembly where beam bunches are formed, the second one is an accelerating cavity. The features of such a gun are the following: bunched and relativistic beams in the output of the injector, absence of the back bombarding electrons, low energy spread and short length of the bunches. The scheme of the injector is shown. The electromagnetic field simulation and longitudinal beam dynamics are presented. The possible using of the injector is discussed.

  7. RF design of X-band RF deflector for femtosecond diagnostics of LCLS electron beam

    Science.gov (United States)

    Dolgashev, Valery A.; Wang, Juwen

    2012-12-01

    We designed a successful constant impedance traveling wave X-band rf deflector for electron beam diagnostics at the 14 GeV SLAC Linac Coherent Light Source (LCLS). This is the first practical deflector built with a waveguide coupler. The 1-meter rf deflector produces 24 MeV peak transverse kick when powered with 20 MW of 11.424 GHz rf. The design is based on our experience with high gradient X-band accelerating structures. Several deflectors of this design have been built at SLAC and are currently in use. Here we describe the design and distinguishing features of this device.

  8. Development of the RF system for the KOMAC MEBT

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong-Gu; Seol, Kyung-Tae; Kwon, Hyeok-Jung; Kim, Han-Sung; Song, Young-Gi; Cho, Yong-Sub [KOMAC, Gyeongju (Korea, Republic of)

    2015-05-15

    In the 100 MeV proton linear accelerator (Linac) for KOMAC, the RF source will power two-accelerator cavities (an RFQ, a DTL1) operated at a frequency of 350 MHz. The low level RF (LLRF) system for 100 MeV proton linear accelerator provides field control including an RFQ and a DTL at 350 MHz. In our system, an accelerating electric field stability of ±1% in amplitude and ±1° in phase is required for the RF system. Eleven radio-frequency (RF) systems are required for the 100 MeV accelerator, which are one RF system for the radio-frequency quadrupole (RFQ) cavity, one RF system for the 20 MeV drift tube linear accelerator (DTL) tanks, two RF systems for the medium-energy beam transmission (MEBT) tanks, and seven RF systems for the 100 MeV DTL tanks. Now a total of 9 RF systems are being operated. To improve the beam quality, the additional RF system for MEBT (Medium Energy Beam Transport) is needed. An addition of a MEBT RF system will reduce loss of beam quantity caused by gab between 20 MeV DTL tank and 100 MeV DTL tank. RF system for MEBT is being installed. The condition of the test is 350 MHz, 9% pulse duty (1.5 ms, 60 Hz), 4 kW(peak power). Perfecting an RF system of MEBT will reduce loss of beam quantity.

  9. CT-guided Bipolar and Multipolar Radiofrequency Ablation (RF Ablation) of Renal Cell Carcinoma: Specific Technical Aspects and Clinical Results

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, C. M., E-mail: christof.sommer@med.uni-heidelberg.de [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Lemm, G.; Hohenstein, E. [Minimally Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Clinic for Radiology (Germany); Bellemann, N.; Stampfl, U. [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Goezen, A. S.; Rassweiler, J. [Clinic for Urology, SLK Kliniken Heilbronn GmbH (Germany); Kauczor, H. U.; Radeleff, B. A. [University Hospital Heidelberg, INF 110, Department of Diagnostic and Interventional Radiology (Germany); Pereira, P. L. [Minimally Invasive Therapies and Nuclear Medicine, SLK Kliniken Heilbronn GmbH, Clinic for Radiology (Germany)

    2013-06-15

    Purpose. This study was designed to evaluate the clinical efficacy of CT-guided bipolar and multipolar radiofrequency ablation (RF ablation) of renal cell carcinoma (RCC) and to analyze specific technical aspects between both technologies. Methods. We included 22 consecutive patients (3 women; age 74.2 {+-} 8.6 years) after 28 CT-guided bipolar or multipolar RF ablations of 28 RCCs (diameter 2.5 {+-} 0.8 cm). Procedures were performed with a commercially available RF system (Celon AG Olympus, Berlin, Germany). Technical aspects of RF ablation procedures (ablation mode [bipolar or multipolar], number of applicators and ablation cycles, overall ablation time and deployed energy, and technical success rate) were analyzed. Clinical results (local recurrence-free survival and local tumor control rate, renal function [glomerular filtration rate (GFR)]) and complication rates were evaluated. Results. Bipolar RF ablation was performed in 12 procedures and multipolar RF ablation in 16 procedures (2 applicators in 14 procedures and 3 applicators in 2 procedures). One ablation cycle was performed in 15 procedures and two ablation cycles in 13 procedures. Overall ablation time and deployed energy were 35.0 {+-} 13.6 min and 43.7 {+-} 17.9 kJ. Technical success rate was 100 %. Major and minor complication rates were 4 and 14 %. At an imaging follow-up of 15.2 {+-} 8.8 months, local recurrence-free survival was 14.4 {+-} 8.8 months and local tumor control rate was 93 %. GFR did not deteriorate after RF ablation (50.8 {+-} 16.6 ml/min/1.73 m{sup 2} before RF ablation vs. 47.2 {+-} 11.9 ml/min/1.73 m{sup 2} after RF ablation; not significant). Conclusions. CT-guided bipolar and multipolar RF ablation of RCC has a high rate of clinical success and low complication rates. At short-term follow-up, clinical efficacy is high without deterioration of the renal function.

  10. Hereditary Gingival Fibromatosis

    Science.gov (United States)

    Nevin, N. C.

    1971-01-01

    Case studies of two siblings suffering from a gum disorder in which enlargement of the gingival mucosa is caused by a fibrosis. The disorder in the two children was felt to be an hereditary recessive trait. (CD)

  11. Pituitary Tumors

    Science.gov (United States)

    ... institutes of the National Institutes of Health (NIH) conduct research related to brain tumors, including pituitary tumors, in their laboratories at ... institutes of the National Institutes of Health (NIH) conduct research related to brain tumors, including pituitary tumors, in their laboratories at ...

  12. RF MEMS Switches for Mobile Communication

    NARCIS (Netherlands)

    Steeneken, Peter; Herfst, Rodolf; Suy, Hilco; Goossens, Martijn; Beek, van Joost; Bielen, Jeroen; Stulemeijer, Jiri; Schmitz, Jurriaan

    2008-01-01

    Switched capacitors based on radio frequency microelectromechanical systems (RF MEMS) can enable a breakthrough in radio technology. Their switching principle is based on the mechanical movement of the plates of a parallel plate capacitor using the electrostatic force. The resulting difference in ca

  13. Novel RF-MEMS capacitive switching structures

    NARCIS (Netherlands)

    Rottenberg, X.; Jansen, H.; Fiorini, P.; De Raedt, W.; Tilmans, H.A.C.

    2002-01-01

    This paper reports on novel RF-MEMS capacitive switching devices implementing an electrically floating metal layer covering the dielectric to ensure intimate contact with the bridge in the down state. This results in an optimal switch down capacitance and allows optimisation of the down/up capacitan

  14. Sources of Emittance in RF Photocathode Injectors

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, David [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2016-12-11

    Advances in electron beam technology have been central to creating the current generation of x-ray free electron lasers and ultra-fast electron microscopes. These once exotic devices have become essential tools for basic research and applied science. One important beam technology for both is the electron source which, for many of these instruments, is the photocathode RF gun. The invention of the photocathode gun and the concepts of emittance compensation and beam matching in the presence of space charge and RF forces have made these high-quality beams possible. Achieving even brighter beams requires a taking a finer resolution view of the electron dynamics near the cathode during photoemission and the initial acceleration of the beam. In addition, the high brightness beam is more sensitive to degradation by the optical aberrations of the gun’s RF and magnetic lenses. This paper discusses these topics including the beam properties due to fundamental photoemission physics, space charge effects close to the cathode, and optical distortions introduced by the RF and solenoid fields. Analytic relations for these phenomena are derived and compared with numerical simulations.

  15. Status of RF superconductivity at Argonne

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, K.W.

    1989-01-01

    Development of a superconducting (SC) slow-wave structures began at Argonne National Laboratory (ANL) in 1971, and led to the first SC heavy-ion linac (ATLAS - the Argonne Tandem-Linac Accelerating System), which began regularly scheduled operation in 1978. To date, more than 40,000 hours of bean-on target operating time has been accumulated with ATLAS. The Physics Division at ANL has continued to develop SC RF technology for accelerating heavy-ions, with the result that the SC linac has, up to the present, has been in an almost continuous process of upgrade and expansion. It should be noted that this has been accomplished while at the same time maintaining a vigorous operating schedule in support of the nuclear and atomic physics research programs of the division. In 1987, the Engineering Physics Division at ANL began development of SC RF components for the acceleration of high-brightness proton and deuterium beams. This work has included the evaluation of RF properties of high-{Tc} oxide superconductors, both for the above and for other applications. The two divisions collaborated while they worked on several applications of RF SC, and also worked to develop the technology generally. 11 refs., 6 figs.

  16. Characterization of dielectric charging in RF MEMS

    NARCIS (Netherlands)

    Herfst, R.W.; Huizing, H.G.A.; Steeneken, P.G.; Schmitz, Jurriaan

    Capacitive RF MEMS switches show great promise for use in wireless communication devices such as mobile phones, but the successful application of these switches is hindered by the reliability of the devices: charge injection in the dielectric layer (SiN) can cause irreversible stiction of the moving

  17. Superconductor Digital-RF Transceiver Components

    Science.gov (United States)

    2006-01-01

    high-power amplifier (HPA). The diagram also shows a dynamic digital equalizer, a digital predistortion module that is combined with the DAC to...intermodulation distortion, especially near their maximum output powers. Unlike conventional baseband or intermediate frequency (IF) predistorters ...which are limited to narrowband correction of slowly varying non- linearities, our RF predistorter can correct instantaneous, signal-dependent

  18. RF Circuit Design in Nanometer CMOS

    NARCIS (Netherlands)

    Nauta, Bram

    2007-01-01

    With CMOS technology entering the nanometer regime, the design of analog and RF circuits is complicated by low supply voltages, very non-linear (and nonquadratic) devices and large 1/f noise. At the same time, circuits are required to operate over increasingly wide bandwidths to implement modern mul

  19. RF Circuit Design in Nanometer CMOS

    NARCIS (Netherlands)

    Nauta, Bram

    2007-01-01

    With CMOS technology entering the nanometer regime, the design of analog and RF circuits is complicated by low supply voltages, very non-linear (and nonquadratic) devices and large 1/f noise. At the same time, circuits are required to operate over increasingly wide bandwidths to implement modern

  20. Theory of RF superconductivity for resonant cavities

    Science.gov (United States)

    Gurevich, Alex

    2017-03-01

    An overview of a theory of electromagnetic response of superconductors in strong radio-frequency (RF) electromagnetic fields is given with the emphasis on applications to superconducting resonant cavities for particle accelerators. The paper addresses fundamentals of the BCS surface resistance, the effect of subgap states and trapped vortices on the residual surface resistance at low RF fields, and a nonlinear surface resistance at strong fields, particularly the effect of the RF field suppression of the surface resistance. These issues are essential for the understanding of the field dependence of high quality factors Q({B}a)∼ {10}10{--}{10}11 achieved on the Nb cavities at 1.3–2 K in strong RF fields B a close to the depairing limit, and the extended Q({B}a) rise which has been observed on Ti and N-treated Nb cavities. Possible ways of further increase of Q({B}a) and the breakdown field by optimizing impurity concentration at the surface and by multilayer nanostructuring with materials other than Nb are discussed.

  1. Binary rf pulse compression experiment at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Lavine, T.L.; Spalek, G.; Farkas, Z.D.; Menegat, A.; Miller, R.H.; Nantista, C.; Wilson, P.B.

    1990-06-01

    Using rf pulse compression it will be possible to boost the 50- to 100-MW output expected from high-power microwave tubes operating in the 10- to 20-GHz frequency range, to the 300- to 1000-MW level required by the next generation of high-gradient linacs for linear for linear colliders. A high-power X-band three-stage binary rf pulse compressor has been implemented and operated at the Stanford Linear Accelerator Center (SLAC). In each of three successive stages, the rf pulse-length is compressed by half, and the peak power is approximately doubled. The experimental results presented here have been obtained at low-power (1-kW) and high-power (15-MW) input levels in initial testing with a TWT and a klystron. Rf pulses initially 770 nsec long have been compressed to 60 nsec. Peak power gains of 1.8 per stage, and 5.5 for three stages, have been measured. This corresponds to a peak power compression efficiency of about 90% per stage, or about 70% for three stages, consistent with the individual component losses. The principle of operation of a binary pulse compressor (BPC) is described in detail elsewhere. We recently have implemented and operated at SLAC a high-power (high-vacuum) three-stage X-band BPC. First results from the high-power three-stage BPC experiment are reported here.

  2. RF building block modelling : optimization and synthesis

    NARCIS (Netherlands)

    Cheng, Wei

    2012-01-01

    For circuit designers it is desirable to have relatively simple RF circuit models that do give decent estimation accuracy and provide sufficient understanding of circuits. Chapter 2 in this thesis shows a general weak nonlinearity model that meets these demands. Using a method that is related to har

  3. RF spectrum sensing in CMOS exploiting crosscorrelation

    NARCIS (Netherlands)

    Oude Alink, Mark Stefan

    2013-01-01

    The introduction of new wireless services, the demand for higher datarates, and higher traffic volumes call for a more efficient use of the RF spectrum than what is currently possible with static frequency allocation. Dynamic spectrum access offers a more efficient use by allowing unlicensed users t

  4. Modeling and simulation for RF system design

    CERN Document Server

    Frevert, Ronny; Jancke, Roland; Knöchel, Uwe; Schwarz, Peter; Kakerow, Ralf; Darianian, Mohsen

    2005-01-01

    Focusing on RF specific modeling and simulation methods, and system and circuit level descriptions, this work contains application-oriented training material. Accompanied by a CD- ROM, it combines the presentation of a mixed-signal design flow, an introduction into VHDL-AMS and Verilog-A, and the application of commercially available simulators.

  5. RF Sputtering of Gold Contacts On Niobium

    Science.gov (United States)

    Barr, D. W.

    1983-01-01

    Reliable gold contacts are deposited on niobium by combination of RF sputtering and photolithography. Process results in structures having gold only where desired for electrical contact. Contacts are stable under repeated cycling from room temperature to 4.2 K and show room-temperature contact resistance as much as 40 percent below indium contacts made by thermalcompression bonding.

  6. Carbon nanotubes for RF and microwaves

    OpenAIRE

    Burke, P. J.; Yu, Z; Rutherglen, C.

    2005-01-01

    In this invited overview paper we provide a brief up-to-date summary of the potential applications of carbon nanotubes for RF and microwave devices and systems. We focus in particular on the use of nanotubes as ultra-high speed interconnects in integrated circuits.

  7. Design of 162 MHz RF Experimental Cavity

    Institute of Scientific and Technical Information of China (English)

    YIN; Zhi-guo; CAO; Xue-long; GUO; Juan-juan; JI; Bin; FU; Xiao-liang; WEI; Jun-yi

    2015-01-01

    In this paper,a 162MHz RF experimental cavity is designed to study the multipacting multiplier effect of the medium and the metal electrode and its relationship with the plate surface characteristics,and to find out the method for inhibiting multipacting multiplier effects.The

  8. RF building block modeling: optimization and synthesis

    NARCIS (Netherlands)

    Cheng, W.

    2012-01-01

    For circuit designers it is desirable to have relatively simple RF circuit models that do give decent estimation accuracy and provide sufficient understanding of circuits. Chapter 2 in this thesis shows a general weak nonlinearity model that meets these demands. Using a method that is related to

  9. RF performance of T-DAB receivers

    NARCIS (Netherlands)

    Schiphorst, R.; Potman, J.; Hofstra, K.L.; Cronie, H.S.; Slump, C.H.

    2008-01-01

    In every wireless system, the weakest link determines the performance of the network. In this paper the Radio Frequency (RF) performance of both band III and L-band Terrestrial Digital Audio Broadcasting (T-DAB) consumer receivers are discussed. The receivers have been tested based on the EN 50248 s

  10. Coherence-Multiplexed Optical RF Feeder Networks

    NARCIS (Netherlands)

    Meijerink, Arjan; Taniman, Robert O.; Etten, van Wim

    2007-01-01

    An optical RF feeding system for wireless access is proposed, in which the radio access points are distinguished by means of coherence multiplexing (CM). CM is a rather unknown and potentially inexpensive optical code division multiple access technique, which is particularly suitable for relatively

  11. Prototype storage cavity for LEP accelerating RF

    CERN Multimedia

    1980-01-01

    The principle of an RF storage cavity was demonstrated with this prototype, working at 500 MHz. The final storage cavities were larger, to suit the LEP accelerating frequency of 352.2 MHz. Cu-tubes for watercooling are brazed onto the upper half, the lower half is to follow. See also 8006061, 8109346, 8407619X, and Annual Report 1980, p.115.

  12. RF electrodynamics in small particles of oxides - a review

    CSIR Research Space (South Africa)

    Srinivasu, VV

    2008-01-01

    Full Text Available RF electrodynamics, particularly, the low field rf absorption in small superconducting and manganite particles is reviewed and compared with their respective bulk counterparts. Experimental and theoretical aspects of the small particle...

  13. RF Anechoic Chambers, Tri-Service Research Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — In collaboration with the Navy, there are 12 RF Anechoic and static free exposure chambers located at TSRL. These chambers cover the majority of the RF spectrum and...

  14. RF Anechoic Chambers, Tri-Service Research Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — In collaboration with the Navy, there are 12 RF Anechoic and static free exposure chambers located at TSRL. These chambers cover the majority of the RF spectrum and...

  15. Thermoradiotherapy of malignant tumors

    Energy Technology Data Exchange (ETDEWEB)

    Hatano, Kazuo; Itami, Jun; Arimizu, Noboru (Chiba Univ. (Japan). School of Medicine); Uno, Takashi; Toita, Takafumi; Shiina, Takeki; Mikuriya, Shuuichi; Yamada, Tsunehisa

    1991-06-01

    From October 1986 to June 1989, 79 patients with malignant tumors were treated by radiation therapy combined with hyperthermia at National Medical Center Hospital. Seventy two patients (male: 48, female: 23) were evaluable. Average age was 62.4 years old (ranged 20-81 years old). Irradiation was delivered twice to fifth weekly in tumor doses of 50 to 60 Gy (TDF 82-122). We used 3 types of hyperthermic equipment, Thermotron RF8, BSD 1000 System and Endoradiotherm 100A. Hyperthermia was initiated within 30 minutes following irradiation, most of the patients being treated with adequate equipment, 41-44degC, for 60-70 minutes every 72 hours. Fifteen of 71 patients (20.8%) showed a complete response and 36 patients (50%) showed a partial response, so effective rate was 70.8% of all. In superficial tumors, 4 of 21 patients (21.5%) showed a complete response and 8 of 21 patients showed a partial response, effective rate was 63.2% of all. In deep seated tumor, 10 of 46 patients (21.7%) showed a complete response and 25 of all patients showed a partial response, so effective rate was 76.1% of all. Five patients were heated following only intra-tumor injection of OK-432 and its effective rate was 75%. We think that this modality of therapy will be effective in cases which heating area had been irradiated over tolerable doses. CR rate of superficial tumors according to intra-tumor center temperature tends to higher in the cases of higher tumor temperature. In deep seated tumor, 11 patients (23.9%) had reached over 43degC, 29 patients (63.0%) heated 41-43degC, 6 patients (13.0%) heated under 41degC and CR rate of each group were 36.4%, 17.2%, 16.7%, respectively. We think that thermotherapy with irradiation is an effective therapy in the treatment of malignancies but the improvement of heating equipment will be expected. (author).

  16. Wavelength-domain RF photonic signal processing

    Science.gov (United States)

    Gao, Lu

    This thesis presents a novel approach to RF-photonic signal processing applications based on wavelength-domain optical signal processing techniques using broadband light sources as the information carriers, such as femtosecond lasers and white light sources. The wavelength dimension of the broadband light sources adds an additional degree of freedom to conventional optical signal processing systems. Two novel wavelength-domain optical signal processing systems are presented and demonstrated in this thesis. The first wavelength-domain RF photonic signal processing system is a wavelength-compensated squint-free photonic multiple beam-forming system for wideband RF phased-array antennas. Such a photonic beam-forming system employs a new modulation scheme developed in this thesis, which uses traveling-wave tunable filters to modulate wideband RF signals onto broadband optical light sources in a frequency-mapped manner. The wavelength dimension of the broadband light sources provides an additional dimension in the wavelength-compensated Fourier beam-forming system for mapping the received RF frequencies to the linearly proportional optical frequencies, enabling true-time-delay beam forming, as well as other novel RF-photonic signal processing functions such as tunable filtering and frequency down conversion. A new slow-light mechanism, the SLUGGISH light, has also been discovered with an effective slow-light velocity of 86 m/s and a record time-bandwidth product of 20. Experimental demonstration of true-time-delay beam forming based on the SLUGGISH light effect has also been presented in this thesis. In the second wavelength-domain RF photonic signal processing system, the wavelength dimension increases the information carrying capacity by spectrally multiplexing multiple wavelength channels in a wavelength-division-multiplexing fiber-optic communication system. A novel ultrafast all-optical 3R (Re-amplification, Retiming, Re-shaping) wavelength converter based on

  17. Fabrication and low-power RF test of C-band RF gun

    Energy Technology Data Exchange (ETDEWEB)

    Taira, Y., E-mail: yoshitaka-taira@aist.go.jp; Kuroda, R.; Tanaka, M.; Kato, H.; Suzuki, R.; Toyokawa, H.

    2014-07-15

    A C-band RF gun for compact radiation sources such as high-energy X-ray and terahertz radiation sources is developed at AIST and is designed to work at a frequency of 5.3 GHz. The total length of this equipment is about 1.5 m. An electron beam with a maximum energy of 0.9 MeV can be generated when the peak electric field is 85 MV/m, corresponding to an RF peak power of 600 kW. A coniferous-tree-type carbon nanostructure is used for the field emission cathode. We present the structural design and fabrication of the C-band RF cavity and a low-power RF test of it.

  18. Modeling of the RF system for the normal conducting linac

    Institute of Scientific and Technical Information of China (English)

    GENG Zhe-Qiao; HOU Mi; PEI Guo-Xi

    2008-01-01

    To study the new RF control methods, a mathematic model of the RF system for the normal conducting linac is built and implemented with the software of Matlab. The model contains some typical units of the RF system, such as the klystron, the SLED and the traveling wave accelerating tube. Finally, the model is used to study the working point of the SLED and the adaptive feed forward algorithm for the RF control system. Simulation shows that the model works well as expected.

  19. The design for the LCLS RF photoinjector

    Energy Technology Data Exchange (ETDEWEB)

    Alley, R.; Bharadwaj, V.; Clendenin, J.; Emma, P.; Fisher, A.; Frisch, J.; Kotseroglou, T. E-mail: theo@slac.stanford.edu; Miller, R.H.; Palmer, D.T.; Schmerge, J.; Sheppard, J.C.; Woodley, M.; Yeremian, A.D.; Rosenzweig, J.; Meyerhofer, D.D.; Serafini, L

    1999-06-01

    We report on the design of the RF photoinjector of the Linac Coherent Light Source. The RF photoinjector is required to produce a single 150 MeV bunch of {approx}1 nC and {approx}100 A peak current at a repetition rate of 120 Hz with a normalized rms transverse emittance of {approx}1{pi} mm-mrad. The design employs a 1.6-cell S-band RF gun with an optical spot size at the cathode of a radius of {approx}1 mm and a pulse duration with an rms sigma of {approx}3 ps. The peak RF field at the cathode is 150 MV/m with extraction 57 deg. ahead of the RF peak. A solenoidal field near the cathode allows the compensation of the initial emittance growth by the end of the injection linac. Spatial and temporal shaping of the laser pulse striking the cathode will reduce the compensated emittance even further. Also, to minimize the contribution of the thermal emittance from the cathode surface, while at the same time optimizing the quantum efficiency, the laser wavelength for a Cu cathode should be tunable around 260 nm. Following the injection linac the geometric emittance simply damps linearly with energy growth. PARMELA simulations show that this design will produce the desired normalized emittance, which is about a factor of two lower than has been achieved to date in other systems. In addition to low emittance, we also aim for laser amplitude stability of 1% in the UV and a timing jitter in the electron beam of 0.5 ps rms, which will lead to less than 10% beam intensity fluctuation after the electron bunch is compressed in the main linac.

  20. Percutaneous radiofrequency ablation for lung tumors beneath the rib under CT fluoroscopic guidance with gantry tilt

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Takanobu; Yamagami, Takuji; Tanaka, Osamu; Yoshimatsu, Rika; Miura, Hiroshi; Nishimura, Tsunehiko (Dept. of Radiology, Graduate School of Medical Science, Kyoto Prefectural Univ. of Medicine, Kamigyo, Kyoto (Japan)), e-mail: yamagami@koto.kpu-m.ac.jp

    2010-05-15

    Background: Radiofrequency (RF) ablation of lung tumors has become a treatment of choice, especially for unresectable cases. However, RF ablation of small lung lesions located just beneath the rib is difficult. Purpose: To evaluate the efficacy and safety of gantry tilting for the performance of RF ablation of peripheral lesions located beneath the rib. Material and Methods: Our study was based on 18 of 293 lesions in the lung for which RF ablation was performed under CT scan fluoroscopic guidance at our institution between October 2004 and March 2009. For these 18 lesions, RF ablation was performed with gantry tilting because a rib blocked visualization of the RF ablation route even after other attempts had been made to change the relationship between the target and the rib. Results: All RF needles, with only one exception, were successfully advanced to hit the tumor. The commonest complication was a pneumothorax, which occurred in seven procedures. No serious complications occurred. The progression-free rates were 82.4% at 6 months, 62.5% at 12 months, and 30% at 24 months. Mean local progression-free duration was 17.6+-11.6 months (range 4-36 months). Conclusion: RF ablation under CT scan fluoroscopic guidance with gantry tilt is a useful and safe technique for RF ablation of lung nodules located beneath the rib

  1. Transversely rf-excited CO/sub 2/ waveguide laser

    Energy Technology Data Exchange (ETDEWEB)

    Lachambre, J.; Macfarlane, J.; Otis, G.; Lavigne, P.

    1978-05-15

    An electrodeless CO/sub 2/ waveguide laser with transverse rf pumping is described. In the rf cw mode, the laser emits up to 0.6 W at 100 Torr. In the rf pulse mode, atmospheric operation has been achieved with pulse duration of 20 ..mu..s and peak power of a few watts at a repetition rate of 300 Hz.

  2. Study of Control Grid Thermionic Cathode RF Gun

    CERN Document Server

    Xiao, Jin; Ming, Li; Xinfan, Yang; Xumin, Shen; Yanan, Chen; Zhou, Xu

    2004-01-01

    In this paper, the beam loading effect of RF Gun was analyzed. To minimize the energy spread, the grid control RF Gun was introduced. The result shows that the grid congrol RF Gun can increase electron beam within 1% energy spread.

  3. MRI manifestation and correlation with pathologic findings in the diagnosis of desmoid-type fibromatosis%韧带样纤维瘤病MRI特征表现及其病理基础

    Institute of Scientific and Technical Information of China (English)

    陈德周; 俞顺; 包强; 苏家威; 杜瑞宾

    2014-01-01

    目的:探讨韧带样纤维瘤病(DF)的MRI特点,重点分析MRI特征影像及其病理基础,评价MRI在DF诊断中的价值。方法回顾性分析经手术病理证实14例韧带样纤维瘤病的M RI表现(14个病灶均行M RI增强及延迟扫描),与术后病理结果进行比较,并探讨M RI特征影像的病理基础。结果14例均为单发病灶(腹外型7例、腹壁型4例、腹内型3例),其中有2例为术后复发,肿瘤沿着肌肉长轴生长。T1 WI呈等或稍低于肌肉的信号,T2 WI呈高于肌肉信号,增强扫描病灶均呈不均匀强化,以延迟强化为明显,病灶内可见条状或带状 T1 WI及 T2 WI低信号,增强后未见强化。14例病灶内均未见坏死、囊变及瘤周水肿。病理组织学上肿瘤由不同比例的成纤维细胞、纤维组织和胶原纤维束组成,纤维细胞及成纤维细胞密集区域T2 WI信号增高,而肿瘤内胶原纤维区域在 T1 WI、T2 WI均为低信号。肿瘤内见较多血管壁完整的毛细血管,这是病灶延迟强化的病理基础。结论病灶内可见T1 WI、T2 WI均呈带状低信号且增强扫描不强化以及病灶延迟强化是DF的特征性M RI表现。M RI可以很好评估肿瘤侵犯范围及其与周围结构的关系,有助于DF的诊断和鉴别诊断。%Objective To explore the magnetic resonance imaging (MRI) features of desmoid-type fibromatosis (DF) ,to analyze emphatically the correction of M RI characteristic features and pathological basis of DF ,and to evaluate the value of MRI in the diagnosis of DF .Methods The MRI imaging characteristics of 14 patients with DF confirmed pathologically were retrospectively analyzed (all the patients were scaned with contrast enhance ) and compared with findings of patholo-gy .Results 14 cases were single lesion (7 lesions were extre-abdominal ,4 lesions were located in the abdominal wall ,oth-ers were intra-abdominal) ,two of which were postoperative

  4. High power solid state rf amplifier for proton accelerator.

    Science.gov (United States)

    Jain, Akhilesh; Sharma, Deepak Kumar; Gupta, Alok Kumar; Hannurkar, P R

    2008-01-01

    A 1.5 kW solid state rf amplifier at 352 MHz has been developed and tested at RRCAT. This rf source for cw operation will be used as a part of rf system of 100 MeV proton linear accelerator. A rf power of 1.5 kW has been achieved by combining output power from eight 220 W rf amplifier modules. Amplifier modules, eight-way power combiner and divider, and directional coupler were designed indigenously for this development. High efficiency, ease of fabrication, and low cost are the main features of this design.

  5. 韧带样纤维瘤病的CT及MRI特征及病理对照%CT and MRI appearance of desmoid-type fibromatosis with pathologic correlation

    Institute of Scientific and Technical Information of China (English)

    袁焕初; 郑晓林; 肖利华; 王刚; 黎群弟

    2014-01-01

    Objective To assess the CT and MRI appearance and pathologic features of desmoid type fibromatosis(DF). Methods 27 patients with pathologically confirmed DF underwent contrast-enhanced CT(12)and MRI(14)with 1 patient having both CT and MRI examinations.Results Of 30 soft tissue DF,14 were located in extra-abdominal and 16 in abdominal wall muscles. All tumors presented as solid masses growing along the long axis of muscles.20 tumors were fusiform or round and 10 were irregular in shape.The margins were well-defined(7)or ill-defined(23).On unenhanced CT,3 tumors were isodense and 10 hypodense relative to the muscle.After intravenous contrast injection,9 tumors showed moderate progressive enhancement and 4 tumors enhanced heterogeneously.On MRI,the lesions were homogeneously T1 isointense(9)or slightly hypointense(9),slightly T2 hyperintense (15)or heterogeneous on T2-weighted images(3).All lesions were hyperintense on STIR-weighted images with bands of low signal intensities in 15.Heterogeneous moderate progressive contrast enhancement was observed in all tumors with non-enhancing T1-and T2-hypointense bands in 12 tumors.Histopathology showed infiltration of fibroblasts and myofibroblasts with compact fibrous and collagen tissues as well as mucus sedimentation.Conclusion DF has CT and MRI features of ill-defined margin,low CT density or MR signal intensity without necrosis and progressive contrast enhancement.%目的:回顾性分析韧带样纤维瘤的CT及MRI特征表现及病理基础。方法收集经手术病理证实的韧带样纤维瘤共27例影像学及病理资料,CT检查12例,MRI检查14例,另1例行CT及MRI检查;全部病例均行增强扫描。结果27例共30个病灶,16个病灶发生于腹壁,14个病灶发生于腹壁外。形态:全部病灶均沿肌纤维长轴生长,20个呈梭形或类圆形,10个不规则形;7个边界较清,23个边界不清。与肌肉密度、信号相比:CT上10个病灶呈稍低密度,3

  6. Desmoid-type fibromatosis of the head and neck region in the paediatric population: a clinicopathological and genetic study of seven cases.

    Science.gov (United States)

    Flucke, Uta; Tops, Bastiaan B J; van Diest, Paul J; Slootweg, Pieter J

    2014-05-01

    Desmoid-type fibromatosis (desmoid) is a locally aggressive (myo)fibroblastic lesion. It represents one of the more common fibrous tumours in children and adolescents. The head and neck region is more often involved than in adults. We investigated the clinicopathological and genetic characteristics of seven paediatric desmoids at this anatomical site, including two cases of desmoplastic fibroma located in the mandible. There were two females and five males with an age range of 1.5-8 years. The sites of the soft tissue lesions were sinonasal (n = 4) and paramandibular (n = 1). All cases showed typical morphology and nuclear β-catenin expression. CTNNB1 gene sequencing, performed successfully in five cases, revealed mutations in three cases with one p.T41A (bone lesion), one p.S37A and one novel mutation, p.D32V (sinonasal soft tissue lesions). Six patients were treated by excision with positive margins in five cases. Follow-up, available for six patients (median 4 years), showed no evidence of disease in four cases, slow progression in one case, and recurrence with stable disease in the last case. Our study provides evidence of genetic similarities in desmoid and desmoplastic fibroma. Additionally, we expanded the spectrum of mutations in CTNNB1 with one novel desmoid mutation. © 2013 John Wiley & Sons Ltd.

  7. Wilms Tumor

    Science.gov (United States)

    ... Wilms tumor is 1 pound at diagnosis. Some children also may have nausea, stomach pain, high blood pressure (hypertension), blood in the urine, loss of appetite, or fever. Even though Wilms tumors often are ...

  8. Hypothalamic tumor

    Science.gov (United States)

    Complications of brain surgery may include: Bleeding Brain damage Death (rarely) Infection Seizures can result from the tumor or from any surgical procedure on the brain. Hydrocephalus can occur with some tumors and ...

  9. Rare Variants in Genes Encoding MuRF1 and MuRF2 Are Modifiers of Hypertrophic Cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Ming Su

    2014-05-01

    Full Text Available Modifier genes contribute to the diverse clinical manifestations of hypertrophic cardiomyopathy (HCM, but are still largely unknown. Muscle ring finger (MuRF proteins are a class of muscle-specific ubiquitin E3-ligases that appear to modulate cardiac mass and function by regulating the ubiquitin-proteasome system. In this study we screened all the three members of the MuRF family, MuRF1, MuRF2 and MuRF3, in 594 unrelated HCM patients and 307 healthy controls by targeted resequencing. Identified rare variants were confirmed by capillary Sanger sequencing. The prevalence of rare variants in both MuRF1 and MuRF2 in HCM patients was higher than that in control subjects (MuRF1 13/594 (2.2% vs. 1/307 (0.3%, p = 0.04; MuRF2 22/594 (3.7% vs. 2/307 (0.7%; p = 0.007. Patients with rare variants in MuRF1 or MuRF2 were younger (p = 0.04 and had greater maximum left ventricular wall thickness (p = 0.006 than those without such variants. Mutations in genes encoding sarcomere proteins were present in 19 (55.9% of the 34 HCM patients with rare variants in MuRF1 and MuRF2. These data strongly supported that rare variants in MuRF1 and MuRF2 are associated with higher penetrance and more severe clinical manifestations of HCM. The findings suggest that dysregulation of the ubiquitin-proteasome system contributes to the pathogenesis of HCM.

  10. Microwave RF antennas and circuits nonlinearity applications in engineering

    CERN Document Server

    Aluf, Ofer

    2017-01-01

    This book describes a new concept for analyzing RF/microwave circuits, which includes RF/microwave antennas. The book is unique in its emphasis on practical and innovative microwave RF engineering applications. The analysis is based on nonlinear dynamics and chaos models and shows comprehensive benefits and results. All conceptual RF microwave circuits and antennas are innovative and can be broadly implemented in engineering applications. Given the dynamics of RF microwave circuits and antennas, they are suitable for use in a broad range of applications. The book presents analytical methods for microwave RF antennas and circuit analysis, concrete examples, and geometric examples. The analysis is developed systematically, starting with basic differential equations and their bifurcations, and subsequently moving on to fixed point analysis, limit cycles and their bifurcations. Engineering applications include microwave RF circuits and antennas in a variety of topological structures, RFID ICs and antennas, micros...

  11. Experimental study of rf pulsed heating

    CERN Document Server

    Laurent, L; Nantista, C; Dolgashev, V; Higashi, Y; Aicheler, M; Tantawi, S; Wuensch, W

    2011-01-01

    Cyclic thermal stresses produced by rf pulsed heating can be the limiting factor on the attainable reliable gradients for room temperature linear accelerators. This is especially true for structures that have complicated features for wakefield damping. These limits could be pushed higher by using special types of copper, copper alloys, or other conducting metals in constructing partial or complete accelerator structures. Here we present an experimental study aimed at determining the potential of these materials for tolerating cyclic thermal fatigue due to rf magnetic fields. A special cavity that has no electric field on the surface was employed in these studies. The cavity shape concentrates the magnetic field on one flat surface where the test material is placed. The materials tested in this study have included oxygen free electronic grade copper, copper zirconium, copper chromium, hot isostatically pressed copper, single crystal copper, electroplated copper, Glidcop (R), copper silver, and silver plated co...

  12. Aluminum nitride for heatspreading in RF IC's

    Science.gov (United States)

    La Spina, L.; Iborra, E.; Schellevis, H.; Clement, M.; Olivares, J.; Nanver, L. K.

    2008-09-01

    To reduce the electrothermal instabilities in silicon-on-glass high-frequency bipolar devices, the integration of thin-film aluminum nitride as a heatspreader is studied. The AlN is deposited by reactive sputtering and this material is shown to fulfill all the requirements for actively draining heat from RF IC's, i.e., it has good process compatibility, sufficiently high thermal conductivity and good electrical isolation also at high frequencies. The residual stress and the piezoelectric character of the material, both of which can be detrimental for the present application, are minimized by a suitable choice of deposition conditions including variable biasing of the substrate in a multistep deposition cycle. Films of AlN as thick as 4 μm are successfully integrated in RF silicon-on-glass bipolar junction transistors that display a reduction of more than 70% in the value of the thermal resistance.

  13. An Efficient RF Source for Jlab

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, M. [Muons, Inc.; Dudas, A. [Muons, Inc.; Rimmer, Robert A. [JLAB; Wang, Haipeng [JLAB

    2013-12-01

    We propose the development of a highly reliable high efficiency RF source for JLAB with a lower lifetime cost operating at 80% efficiency with system operating costs of about 0.7M$/year for the 6 GeV machine. The design of the RF source will be based upon two injection locked magnetrons in a novel combining architecture for amplitude modulation and a cross field amplifier (CFA) as an output tube for the 12 GeV upgrade. A cost analysis including efficiency and reliability will be performed to determine the optimum system architecture. Several different system architectures will be designed and evaluated for a dual injection locked magnetron source using novel combining techniques and possibly a CFA as the output tube. A paper design for the 1497 MHz magnetron system will be completed. The optimum system architecture with all relevant specifications will be completed so that a prototype can be built.

  14. ILC RF System R and D

    Energy Technology Data Exchange (ETDEWEB)

    Adolphsen, Chris; /SLAC

    2012-07-03

    The Linac Group at SLAC is actively pursuing a broad range of R&D to improve the reliability and reduce the cost of the L-band (1.3 GHz) rf system proposed for the ILC linacs. Current activities include the long-term evaluation of a 120 kV Marx Modulator driving a 10 MW Multi-Beam Klystron, design of a second-generation Marx Modulator, testing of a sheet-beam gun and beam transport system for a klystron, construction of an rf distribution system with remotely-adjustable power tapoffs, and development of a system to combine the power from many klystrons in low-loss circular waveguide where it would be tapped-off periodically to power groups of cavities. This paper surveys progress during the past few years.

  15. RUGGED CERAMIC WINDOW FOR RF APPLICATIONS

    Energy Technology Data Exchange (ETDEWEB)

    MIKE NEUBAUER

    2012-11-01

    High-current RF cavities that are needed for many accelerator applications are often limited by the power transmission capability of the pressure barriers (windows) that separate the cavity from the power source. Most efforts to improve RF window design have focused on alumina ceramic, the most popular historical choice, and have not taken advantage of new materials. Alternative window materials have been investigated using a novel Merit Factor comparison and likely candidates have been tested for the material properties which will enable construction in the self-matched window configuration. Window assemblies have also been modeled and fabricated using compressed window techniques which have proven to increase the power handling capability of waveguide windows. Candidate materials have been chosen to be used in fabricating a window for high power testing at Thomas Jefferson National Accelerator Facility.

  16. SPS RF System an Accelerating Cavity

    CERN Multimedia

    CERN PhotoLab

    1975-01-01

    The picture shows one of the two initially installed cavities. The main RF-system of the SPS comprises four cavities: two of 20 m length and two of 16.5 m length. They are all installed in one long straight section (LSS 3). These cavities are of the travelling-wave type operating at a centre frequency of 200.2 MHz. They are wideband, filling time about 700 ns and untuned. The power amplifiers, using tetrodes are installed in a surface building 200 m from the cavities. Initially only two cavities were installed, a third cavity was installed in 1978 and a forth one in 1979. The number of power amplifiers was also gradually increased: by end 1980 there were 8 500 kW units combined in pairs to feed each of the 4 cavities with up to about 1 MW RF power, resulting in a total accelerating voltage of about 8 MV. See also 7412017X, 7411048X.

  17. Matching Parasitic Antenna for Single RF MIMO

    DEFF Research Database (Denmark)

    Han, Bo; Kalis, A; Nielsen, Rasmus Hjorth

    2012-01-01

    Single RF MIMO communication emerges a novel low cost communication method which does not consume as much power as the conventional MIMO. The implementation of such single RF MIMO system is done by mapping the weighting factors to the polarizations or the radiation patterns of the antennas....... In order to have such performance, an antenna with rich pattern modes is required by the system, thus the ESPAR antenna is investigated. The critical part on such antenna is parasitic element impedance matching. Unlike the conventional smith-chart matching method which assumes the minimal resistance...... is zero and with goal of 50 ohm or 75 ohm matching, matching on such parasitic antenna will adopt negative value as well. This paper presents a matching network with controllable impedance even to the range of negative values....

  18. Cognitive Radio RF: Overview and Challenges

    Directory of Open Access Journals (Sweden)

    Van Tam Nguyen

    2012-01-01

    Full Text Available Cognitive radio system (CRS is a radio system which is aware of its operational and geographical environment, established policies, and its internal state. It is able to dynamically and autonomously adapt its operational parameters and protocols and to learn from its previous experience. Based on software-defined radio (SDR, CRS provides additional flexibility and offers improved efficiency to overall spectrum use. CRS is a disruptive technology targeting very high spectral efficiency. This paper presents an overview and challenges of CRS with focus on radio frequency (RF section. We summarize the status of the related regulation and standardization activities which are very important for the success of any emerging technology. We point out some key research challenges, especially implementation challenges of cognitive radio (CR. A particular focus is on RF front-end, transceiver, and analog-to-digital and digital-to-analog interfaces which are still a key bottleneck in CRS development.

  19. Superconducting RF separator for Omega Spectrometer

    CERN Multimedia

    1977-01-01

    The photo shows an Nb-deflector for the superconducting RF separator ready for installation in its cryostat (visible at the back). Each deflector was about 3 m long. L. Husson and P. Skacel (Karlsruhe) stand on the left, A. Scharding (CERN) stands on the right. This particle separator, the result of a collaboration between the Gesellshaft für Kernforschung, Karlsruhe, and CERN was installed in the S1 beam line to Omega spectrometer. (See Annual Report 1977.)

  20. RF Control and Measurement of Superconducting Qubits

    Science.gov (United States)

    2015-02-14

    208047 New Haven, CT 06520 -8047 14-Sep-2014 ABSTRACT Final Report: RF Control and Measurement of Superconducting Qubits Report Title This is the final...project duration, to the generation a new architecture which, while taking into account the limitations discovered in the other research line of the...materials properties. Third, spurious electromagnetic modes, not accounted for in the Hamiltonian (1), can spuriously couple to the atoms or the