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Sample records for fibroids mid-long term

  1. Mid-long Term Optimal Dispatching Method of Hydro-thermal Power System Considering Scheduled Maintenance

    Institute of Scientific and Technical Information of China (English)

    GE Xiaolin; SHU Jun; ZHANG Lizi

    2012-01-01

    Mid-long term hydro-thermal optimal dispatching plays an important role in mid-long term electric power and energy balance, and it also can bring significant economic benefits. This topic has been discussed in many literatures and some progress has been achieved, but there are still two problems that need to be solved. First, the modeling approach needs to be improved. When a multi-scenario model is adopted in hydro-thermal optimal dispatching, the existing modeling approaches will probably suffer from the dimensionality problem. Second, the construction of the mathematical model is not comprehensive. Generally, the existing model only considers the power balance;

  2. A Hybrid Model for the Mid-Long Term Runoff Forecasting by Evolutionary Computaion Techniques

    Institute of Scientific and Technical Information of China (English)

    Zou Xiu-fen; Kang Li-shan; Cae Hong-qing; Wu Zhi-jian

    2003-01-01

    The mid-long term hydrology forecasting is one of most challenging problems in hydrological studies. This paper proposes an efficient dynamical system prediction model using evolutionary computation techniques. The new model overcomes some disadvantages of conventional hydrology fore casting ones. The observed data is divided into two parts: the slow "smooth and steady" data, and the fast "coarse and fluctuation" data. Under the divide and conquer strategy, the behavior of smooth data is modeled by ordinary differential equations based on evolutionary modeling, and that of the coarse data is modeled using gray correlative forecasting method. Our model is verified on the test data of the mid-long term hydrology forecast in tbe northeast region of China. The experimental results show that the model is superior to gray system prediction model (GSPM).

  3. The influence of human activity and precipitation change on mid-long term evolution of landslide and debris flow disasters

    Institute of Scientific and Technical Information of China (English)

    Yun Tao; Chuan Tang

    2013-01-01

    After defining landslide and debris flow, human activity, and precipitation indices, using with landslide and debris flow disaster data in low-latitude plateau of China, reflecting human activity and precipitation data, the influence of human activity and precipitation on mid-long term evolution of landslide and debris flow was studied with the wavelet technique. Results indicate that mid-long evolution of landslide and debris flow disaster trends to increase 0.9 unit every year, and presents obvious stage feature. The abrupt point from rare to frequent periods took place in 1993. There is significant in-phase resonance oscillation between human activity and landslide and debris flow frequency on a scale of 11-16 years, in which the variation of human activity occurs about 0.2-2.8 years before landslide and debris flow variation. Thus, the increase of landslide and debris flow frequency in low latitude plateau of China may be mainly caused by geo-environmental degradation induced by human activity. After the impact of human activity is removed, there is sig-nificant in-phase resonance oscillation between landslide and debris flow frequency and summer rainfall in low-latitude plateau of China in quasi-three-year and quasi-six-year scales, in which the variation of summer precipitation occurs about 0.0-0.8 years before landslide and debris flow variation. Summer precipitation is one of important external causes which impacts landslide and debris flow frequency in low-latitude plateau of China. The mid-long term evolution predicting model of landslide and debris flow disasters frequency in low-latitude plateau region with better fitting and predicting ability was built by considering human activity and summer rainfall.

  4. Prospect of Mid-long Term Oil & Gas System Reform in China

    Institute of Scientific and Technical Information of China (English)

    Guo Jiaofeng

    2015-01-01

    International oil keeps low-price running after crash, and China deepens reform domestically. Using this opportunity, China lays the same emphasis on investment and trade, on onshore and offshore transportation, gives full play to the important role of market in resource distribution, speeds up oil and gas system reform to guarantee clean, efficient, safe and steady energy supply and long-term demand for energy. We systematically and thoroughly established legal system for oil and gas domains, reformed management system for energy domain, reformed regulatory domain, built modern market entity and multi-level market system, and improved oil and gas pricing mechanism, etc.

  5. Long-term results of symptomatic fibroids treated with uterine artery embolization: In conjunction with MR evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Man Deuk [Department of Diagnostic Radiology Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of)], E-mail: mdkim@cha.ac.kr; Lee, Hyun Seok [Department of Diagnostic Radiology Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of); Lee, Mee Hwa [Department of Obstetrics and Gynecology, Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of); Kim, Hee Jin [Department of Diagnostic Radiology Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of); Cho, Jin Ho; Cha, Sun Hee [Department of Obstetrics and Gynecology, Bundang CHA General Hospital, Pochon CHA University (Korea, Republic of)

    2010-02-15

    Objective: The aim of the present study is to determine long-term clinical efficacy of uterine fibroid embolization (UFE) for symptomatic fibroids in conjunction with MR evaluation. Materials and methods: Sixteen patients with a follow-up period of 4 years or longer were analyzed retrospectively. Ages ranged from 27 to 45 (mean 39.5) years. Mean follow-up periods were 5.8 years (range: 4.1-6.9 years). The symptom changes, in terms of menorrhagia and dysmenorrhea and bulk-related symptoms, were assessed. The primary embolic agent was polyvinyl alcohol particle (250-710 {mu}m). All patients underwent preprocedural and long-term follow up MR imaging. Uterine volumes were calculated using MRI. Results: Symptom improvements were reported for menorrhagia (8/9, 88.9%), dysmenorrhea (5/5, 100%), and bulk-related symptoms (7/9, 77.8%) at long-term follow up. Two patients (12.5%) had symptom recurrences at long-term follow-up. Tumor regrowth from incomplete infarction was a cause of recurrence in one patient and newly developed leiomyomas in the other one. One patient underwent hysterectomy because endometriosis developed 4 years after UFE. Of the 14 necrotic myomas on short-term follow up MR after UFE, eight (57.1%) demonstrated maintaining necrosis with further shrinkage and six (42.9%) were no longer visualized on long-term follow up MR images. Overall, the mean volume reduction rates of the predominant fibroid and uterus were 80.5%, 36.7% at long-term follow up, respectively. Conclusion: UFE is an effective treatment for symptomatic fibroids with an acceptable long-term success rate. Long-term MR imaging after UFE revealed persistent necrotic fibroid, non-visualization of fibroids and tumor regrowth when incompletely infarcted.

  6. Long-term intermittent pharmacological therapy of uterine fibroids – a possibility to avoid hysterectomy and its negative consequences

    Directory of Open Access Journals (Sweden)

    Anita Olejek

    2016-03-01

    Full Text Available Uterine fibroids are found in almost 20-40% of women of reproductive age. For each woman an individualised treatment method should be applied because the hysterectomy procedure is not a good option in every case. The uterus is an organ necessary not only in reproduction. Its removal may result in: pelvic floor dysfunction and stress urinary incontinence, negative impair on life quality, depressive disorders, increased risk of cardiovascular and neurodegenerative diseases, and higher incidence of neoplastic disease. According to the last scientific reports, selective progesterone receptor modulators are the effective therapeutic option in uterine fibroids in women of reproductive age because progesterone is an important factor in their pathogenesis. Ulipristal acetate (UPA is a progesterone receptor antagonist. It inhibits cell proliferation and angiogenesis in uterine fibroids and also reduces collagen deposits in extracellular matrix. Significant data concerning ulipristal acetate efficacy have been provided by scientific research, especially from the consecutive PEARL studies. Oral ulipristal acetate effectively and safely controls bleeding and pain in patients with symptomatic fibroids. It reduces fibroid volume and restores quality of life. The results of UPA long-term intermittent treatment are largely maintained during the off-treatment periods.

  7. Uterine Fibroids

    Science.gov (United States)

    ... permits the doctor to see fibroids inside the uterine cavity. Hysterosalpingography is a special X-ray test. It ... used to remove fibroids that protrude into the cavity of the uterus. A resectoscope is inserted through the hysteroscope. The ...

  8. Clinical Long-Term Outcome and Reinterventional Rate After Uterine Fibroid Embolization with Nonspherical Versus Spherical Polyvinyl Alcohol Particles

    Energy Technology Data Exchange (ETDEWEB)

    Duvnjak, Stevo, E-mail: stevo.duvnjak@rsyd.dk [Odense University Hospital, Department of Radiology (Denmark); Ravn, Pernille [Odense University Hospital, Department of Gynecology (Denmark); Green, Anders [Odense University Hospital, Odense Patient Data Explorative Network (Denmark); Andersen, Poul Erik [Odense University Hospital, Department of Radiology (Denmark)

    2016-02-15

    PurposeThis study was designed to evaluate the long-term clinical outcome and frequency of reinterventions in patients with uterine fibroids treated with embolization at a single center using polyvinyl alcohol microparticles.MethodsThe study included all patients with symptomatic uterine fibroids treated with uterine fibroid embolization (UFE) with spherical (s-PVA) and nonspherical (ns-PVA) polyvinyl alcohol microparticles during the period January 2001 to January 2011. Clinical success and secondary interventions were examined. Hospital records were reviewed during follow-up, and symptom-specific questionnaires were sent to all patients.ResultsIn total, 515 patients were treated with UFE and 350 patients (67 %) were available for long-term clinical follow-up. Median time of follow-up was 93 (range 76–120.2) months. Eighty-five patients (72 %) had no reinterventions during follow-up in the group embolized with ns-PVA compared with 134 patients (58 %) treated with s-PVA. Thirty-three patients (28 %) underwent secondary interventions in the ns-PVA group compared with 98 patients (42 %) in s-PVA group (χ{sup 2} test, p < 0.01).ConclusionsSpherical PVA particles 500–700 µm showed high reintervention rate at long-term follow-up, and almost one quarter of the patients underwent secondary interventions, suggesting that this type of particle is inappropriate for UFE.

  9. Complexity Research on Mid-Long Term Forecast of Regional Power Load%区域电力负荷中长期预测复杂性研究

    Institute of Scientific and Technical Information of China (English)

    崔和瑞; 刘冬

    2011-01-01

    为了解决我国各个地区电力需求区域性、结构性波动的问题,保持国民经济和区域经济的持续健康发展,创新性地将区域电力负荷中长期预测作为一个系统研究,并从4个方面对其复杂性进行分析。描述了区域电力需求的系统构成,分析了区域中长期电力负荷预测的影响因素和复杂性特征,提出区域电力负荷中长期预测复杂性测度模型。%In order to solve the problem of regional and structural fluctuations of the power demand all over China,and maintain the sustainable and healthy development of national and regional economy,this paper made a creative and systematic study on mid-long term forecast of regional power load,and analyzed its complexity from four perspectives.The system structure of regional power demand is described;influencing factors and complex characteristics are analyzed;and the complexity measure model for regional power load mid-long term forecasting is proposed.

  10. Medical Treatments for Fibroids

    Science.gov (United States)

    ... NICHD Research Information Clinical Trials Resources and Publications Medical Treatments for Fibroids Skip sharing on social media ... Page Content Your health care provider may suggest medical treatments to reduce the symptoms of fibroids or ...

  11. Uterine Fibroid Embolization (UFE)

    Science.gov (United States)

    ... embolization. This occurs when fibroids located inside the uterine cavity detach after embolization. Women with this problem may require a procedure called D & C (dilatation and curettage) to ... who undergo uterine fibroid embolization, normal menstrual cycles resume after the ...

  12. Mid-long Term Load Forecasting Based on Fuzzy Soft Set and DS Evidence Theory%基于模糊软集和DS证据理论的中长期负荷预测

    Institute of Scientific and Technical Information of China (English)

    牛东晓; 范磊磊

    2013-01-01

    According to the errors between the predicted values and the actual values,a fuzzy soft set is established in the form of membership function,then utilizes Dempster combination rule in evidence theory to synthesize the prediction results to obtain the weights of each single model,and thus builds a new hybrid combination forecasting model.The example shows that the proposed model can effectively improve the accuracy of mid-long term load forecasting,and is more accurate and credible than the combination forecasting model based on entropy or simply fuzzy soft set theory.%根据预测值与实际值间的误差,以隶属度函数形式建立模糊软集,然后运用DS证据理论将每年的预测情况进行证据融合,得到各个单一预测模型对应的权重,进而建立1个新的混合型组合预测模型.实例表明,本文模型能有效提高中长期负荷预测精度,而且优于基于熵或者单纯模糊软集理论的组合预测模型.

  13. Outcome of uterine artery embolization versus MR-guided high-intensity focused ultrasound treatment for uterine fibroids: Long-term results

    Energy Technology Data Exchange (ETDEWEB)

    Froeling, V., E-mail: Vera.Froeling@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Meckelburg, K., E-mail: Katrin.Meckelburg@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Schreiter, N.F., E-mail: Nils.Schreiter@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Scheurig-Muenkler, C., E-mail: Christian.Scheurig@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Kamp, J., E-mail: Julia.Kamp@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Maurer, M.H., E-mail: Martin.Maurer@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Beck, A., E-mail: Alexander.Beck@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); Hamm, B., E-mail: Bernd.Hamm@charite.de [Department of Radiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin (Germany); and others

    2013-12-01

    Objectives: To compare the long-term outcome after uterine artery embolization (UAE) versus magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic uterine fibroids. Methods: Seventy-seven women (median age, 39.3 years; range, 29.2–52.2 years) with symptomatic uterine fibroids, equally eligible for UAE and MR-g HIFU based on our exclusion criteria underwent treatment (UAE, N = 41; MR-g HIFU, N = 36) from 2002 to 2009 at our institution. Symptom severity (SS) and total health-related quality of life (Total HRQoL) scores were assessed by the uterine fibroid symptom and quality of life (UFS-QoL) questionnaire before treatment and at long-term follow-up after UAE (median 61.9 months) and after MR-g HIFU (median: 60.7 months). Re-intervention rates were assessed for each therapy and compared. Results: Re-intervention was significantly lower after UAE (12.2%) than after MR-g HIFU (66.7%) at long-term follow-up (p < 0.001). After UAE changes in SS (50 pre-treatment vs. 6.3 post-treatment) and Total HRQoL (57.8 pre-treatment vs. 100 post-treatment) were significantly better than changes in SS (42.2 pre-treatment vs. 26.6 post-treatment) and Total HRQoL score (66.4 pre-treatment vs. 87.9 post-treatment) after MR-g HIFU (p = 0.019 and 0.049 respectively). Conclusions: Improvement of SS and Total HRQoL scores was significantly better after UAE resulting in a significant lower re-intervention rate compared to MR-g HIFU.

  14. 中长期飞行对人体超重耐力影响及防护技术研究%Research on Effects of Mid-Long-Term Flight on Human +Gx Endurance and Protection Measures

    Institute of Scientific and Technical Information of China (English)

    吴萍; 吴斌; 陈晓萍; 阚广悍; 谷志明; 黄伟芬; 白延强; 王跃; 刘敏

    2015-01-01

    为探讨中长期空间飞行(30 d以上)后飞船应急返回对机体超重耐力的影响及防护技术,首先选用42只健康雄性成年猕猴,随机分为4组,进行中长期模拟失重再超重的病理生理影响及其机理研究;之后选22名健康被试者,随机平均分为2组,分别穿着绳索拉紧式和充气式抗荷服,测定各自选定的高低2种压力制度时的下体负压耐力;最后选8名健康志愿者,测试在不穿抗荷服、穿着绳索拉紧式和充气式抗荷服三种状态下承受超重过载时的生理反应。实验表明,高+Gx作用,使猕猴脏器出现病理性损伤,相同G值猕猴头低位卧床后再超重组引起的病理损伤要比单纯超重组严重;绳索拉紧式抗荷服和充气式抗荷服可以提高人体下体负压耐力和超重耐力。%The main purpose of this study is to investigate the influence of spaceship emergency re-turn on body hyper-gravity endurance after mid-long-term flight ( over 30 days ) and the protection measures, and to provide theoretical basis for formulating the hyper-gravity medical standard for spaceship emergency return after mid-long-term flight and developing space protective suits .Forty-two healthy male rhesus monkeys were selected as the test subjects and were randomly divided into 4 groups, to study on the pathophysiological effects of long-term simulated weightlessness plus hyper-gravity and its mechanism .Twenty-two healthy subjects were selected and randomly divided into two groups, wearing rope taut anti-G suit and inflatable anti-G suit respectively .Lower body negative pressure tolerance was measured in the chosen pressure .Finally 8 healthy volunteers were selected and their physiological responses to hyper-gravity with anti-G suit, or rope taut anti-G suit or inflata-ble anti-G suits were measured .The results showed that high +Gx caused pathologic organ damage in rhesus monkeys , and pathological damage in the same G

  15. Uterine Fibroid Embolization for Symptomatic Fibroids: Study at a Teaching Hospital in Kenya

    Directory of Open Access Journals (Sweden)

    John Kiprop Mutai

    2015-01-01

    Full Text Available Objective: Characterization of magnetic (MRI features in women undergoing uterine fibroid embolization (UFE and identification of clinical correlates in an African population. Materials and Methods: Patients with symptomatic fibroids who are selected to undergo UFE at the hospital formed the study population. The baseline MRI features, baseline symptom score, short-term imaging outcome, and mid-term symptom scores were analyzed for interval changes. Assessment of potential associations between short-term imaging features and mid-term symptom scores was also done. Results: UFE resulted in statistically significant reduction (P < 0.001 of dominant fibroid, uterine volumes, and reduction of symptom severity scores, which were 43.7%, 40.1%, and 37.8%, respectively. Also, 59% of respondents had more than 10 fibroids. The predominant location of the dominant fibroid was intramural. No statistically significant association was found between clinical and radiological outcome. Conclusion: The response of uterine fibroids to embolization in the African population is not different from the findings reported in other studies from the west. The presence of multiple and large fibroids in this study is consistent with the case mix described in other studies of African-American populations. Patient counseling should emphasize the independence of volume reduction and symptom improvement. Though volume changes are of relevance for the radiologist in understanding the evolution of the condition and identifying potential technical treatment failures, it should not be the main basis of evaluation of treatment success.

  16. Expulsion of dominant submucosal fibroids after uterine artery embolization

    Energy Technology Data Exchange (ETDEWEB)

    Radeleff, Boris, E-mail: Boris_radeleff@med.uni-heidelberg.d [Department of Diagnostic and Interventional Radiology, University of Heidelberg (Germany); Eiers, Michael; Bellemann, Nadine; Ramsauer, Stefanie [Department of Diagnostic and Interventional Radiology, University of Heidelberg (Germany); Rimbach, Stefan [Department of Gynecology, University of Konstanz (Germany); Kauczor, Hans-Ulrich [Department of Diagnostic and Interventional Radiology, University of Heidelberg (Germany); Richter, Goetz M. [Department of Diagnostic and Interventional Radiology, University of Heidelberg (Germany); Clinic of Diagnostic and Interventional Radiology, Katharinenhospital, Stuttgart (Germany)

    2010-07-15

    Purpose: Purpose of this study was to evaluate the frequency, probability, and factors associated with expulsion of submucosal fibroids after uterine artery embolization (UAE) in addition to the technical and clinical results at 1-year follow-up. Materials and methods: We determined the preinterventional volume of each dominant submucosal fibroid using the commonly used ellipsoid formula and a 3D volumetry in the MRI to define a threshold value in milliliters that indicates the probability for a fibroid expulsion. Assessment of fibroid expulsion was done by MRI at 3-month intervals for a year. Assessment of clinical mid term success was achieved by applying questionnaires at 1-year follow-up. Results: Technical success was observed in all 20 patients (mean age of 41.4 {+-} 5.6 years; range: 29.2-51.1 years). Two (10%) minor and one (5%) major complications occurred. 10/20 dominant submucosal fibroids were completely expelled during the follow-up. Using 3D MRI volumetry the preinterventional mean volume of the later expelled fibroids was 56.8 {+-} 57.0 ml (range 2.3-198.0 ml) and the mean volume of non-expelled fibroids was 123.8 {+-} 147.3 ml (range 24.0-531.8 ml). This difference was statistically significant, but weak (p = 0.0494). Fibroids with a volume equal or less than the threshold value (66.0 ml) were 73% likely to be expelled and fibroids larger than 66.0 ml were 78% likely not to be expelled. All 20 patients demonstrated a significant reduction in the fibroid related symptoms. Conclusion: In our study the complication rate was low despite increased rates of fibroid expulsion (50%); simultaneously the rate of treatment satisfaction was very high. Patients with a dominant submucosal fibroid under 66.0 ml should be informed about the probability of fibroid expulsion and the accompanying symptoms.

  17. Uterine Fibroids Fact Sheet

    Science.gov (United States)

    ... uterus through the vagina, instead of making a cut in the abdomen. In some cases hysterectomy can ... into the blood vessels. This blocks the blood supply to the fibroid, causing it to shrink. UFE can be an outpatient ... warning on power morcellators in treatment for uterine fibroids If your ...

  18. A rare case of repeated expulsions of a giant cervical fibroid per vaginum followed by delivery of near term babies in two consecutive pregnancies

    Directory of Open Access Journals (Sweden)

    Vaibhav Kanti

    2014-06-01

    Full Text Available Huge cervical fibroid polyp with red degeneration, obstructing birth canal might be a night mare for obstetricians. Most of us will plan for a caesarean section but somehow due to lack medical consultation; a patient in rural setup with a huge cervical fibroid, delivered normal in two consecutive pregnancies. This case is unique because no such case has been reported in literature where normal delivery took place twice in the same patient, with such a huge fibroid with red degeneration, obstructing the birth canal. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 790-792

  19. Mid-long term effect analysis of primary cemented total hip arthroplasty%初次骨水泥型人工全髋关节置换术的中远期疗效分析

    Institute of Scientific and Technical Information of China (English)

    温亮; 潘江; 曲铁兵; 林源; 王进军; 方超华

    2014-01-01

    Objective To evaluate the mid-long term clinical and radiographic effects of the primary cemented total hip arthroplasty ( THA).Methods One hundred and eighty-seven patients (201 hips) who had undergone primary cemented THA from July 1991 to June 2006 were followed up for their post-operative complications and imaging findings .Harris score and bone density value were used for statistical analysis .The survival rate of the implants was determined by using the revision of either prosthetic component for any reason as the end-point during the follow-up.Results One hundred and seventeen patients (126 hips) were followed up for 13.5 years averagely in the end .Harris score improved significantly from (32.8 ±22.5) points to (90.3 ±7.3) points (t =-27.91,P 0.05).There was late infection in one hip, dislocation in three hips, DVT in four hips, inequality of lower limb in four hips , periprosthetic fracture in two hips , heterotopic ossification in six hips and aseptic loosening in five hips.Seven hips were revised after a mean time of 11.3 years.The survival rate of the implants was 94.4%.Conclusion The study suggests that the cemented THA may be suitable for treating all kinds of severe diseases of the hip joint for the senile osteoporosis patients and it can acheive good clinical outcomes .The cemented implant has satisfactory long-term results.%目的:回顾性分析初次骨水泥型全髋关节置换术( THA)的中远期临床及影像学疗效、假体的生存率及其相关影响因素。方法对1991年7月至2006年6月间接受初次骨水泥型THA的患者187例(201髋)进行随访。观察并发症情况、影像学表现,并对Harris评分和骨密度结果值进行统计学分析,以假体翻修为随访终点,计算假体的生存率。结果共117例(126髋)获得完整随访,平均随访时间为13.5年。 Harris评分由术前的(32.8±22.5)分提高至末次随访时的(90.3±7.3)分,差异有统计学意义( t

  20. Mid-long term efficacy of osteo-periosteal turned over orthotopically for chondromalacia patellae%骨-骨膜原位翻转修复髌软骨软化症的中长期疗效

    Institute of Scientific and Technical Information of China (English)

    李哲海; 张霄雁; 张飞; 武宇赤; 郭永强

    2011-01-01

    Objective To investigate the method of osteo-periosteal turned over orthotopically for treating chondromalacia patellae disease and observe the mid-long term efficacy postoperatively.Methods From April 1996 to June 2000,21 patients with chondromalacia patellae were treated in our hospital.Amone them,13 cases were performed osteo-periosteal turned over orthotopically,including 3 males,10 females; with the mean age of 59 years (range,47-65 years).HSS and Lysholm knee rating scale were employed to analysis the results.Results The patients were followed up from 114 to 162 months (mean,133.2 months).One of the patients lost follow-up due to death.Before operation the HSS knee score was 20-58 (34.2±3.8),and 1 year,3 year,5 year,7 year,and 9 year after operation the HSS knee score were 55-70 (60.0±7.0),55-82 (64.1±5.9),60-90 (70.1±3.2),50-85 (63.1±4.1),and 50-75 (57.3±2.9) respectively.And Lysholm knee rating scale also showed similar results.The chondromalacia patellae patients before and after operation were significant different.Bone periosteum transplant tissue and surrounding defective tissue healed perfectly,functions recovered perfectly.Conclusion The method of osteo-periosteal turned over orthotopically has the capabilities to form cartilage.The therapeutic effect and facies articularis patellar is satisfactory.But it only can restore articular cartilage of patellar and does not help for genual malformation.%目的 探讨骨-骨膜原位翻转修复治疗髌骨软化症的软骨缺损方法,观察其中长期疗效.方法 1996年4月至2000年6月,拟在我院手术治疗的21例髌软骨软化症患者经术前和术中评估,接受骨-骨膜原位翻转术治疗13例.男3例,女10例;年龄47~65岁,平均59岁.采用HSS和Lysholm 膝关节功能评分标准进行评分.结果 术后随访114 ~162个月(平均133.2个月),13例患者中1例患者死亡,余12例获随访.按照HSS膝关节功能评分标准:术前20~58(34.2±3.8)分,术后1年为55

  1. [Electrotherapy and uterine fibroids].

    Science.gov (United States)

    Deroover, J

    2009-01-01

    At the end of the 19th century, uterine fibroids cause huge therapeutic issues: on the one hand they can reach an impressive massive volume; on the other hand they provoke endless haemorrhages. Dr Apostoli develops galvanotherapy which becomes the reference in French and international medicine before its rapid downfall as gynaecological surgery makes great progress at the beginning of the 20th Century.

  2. Fibroid Tumors in Women: A Hidden Epidemic?

    Science.gov (United States)

    ... Issue Past Issues Fibroid Tumors in Women: A Hidden Epidemic? Past Issues / Spring 2007 Table of Contents ... fibroids@rics.bwh.harvard.edu , or visit our Web site: www.fibroids.net . You may also write ...

  3. Infertility and uterine fibroids.

    Science.gov (United States)

    Zepiridis, Leonidas I; Grimbizis, Grigoris F; Tarlatzis, Basil C

    2016-07-01

    Uterine fibroids are the most common tumors in women and their prevalence is higher in patients with infertility. At present, they are classified according to their anatomical location, as no classification system includes additional parameters such as their size or number. There is a general agreement that submucosal fibroids negatively affect fertility, when compared to women without fibroids. Intramural fibroids above a certain size (>4 cm), even without cavity distortion, may also negatively influence fertility. However, the presence of subserosal myomas has little or no effect on fertility. Many possible theories have been proposed to explain how fibroids impair fertility: mechanisms involving alteration of local anatomical location, others involving functional changes of the myometrium and endometrium, and finally endocrine and paracrine molecular mechanisms. Nevertheless, any of the above mentioned mechanisms can cause reduced reproductive potential, thereby leading to impaired gamete transport, reduced ability for embryo implantation, and creation of a hostile environment. The published experience defines the best practice strategy, as not many large, well-designed, and properly powered studies are available. Myomectomy appears to have an effect in fertility improvement in certain cases. Excision of submucosal myomas seems to restore fertility with pregnancy rates after surgery similar to normal controls. Removal of intramural myomas affecting pregnancy outcome seems to be associated with higher pregnancy rates when compared to non-operated controls, although evidence is still nοt sufficient. Treatment of subserosal myomas of reasonable size is not necessary for fertility reasons. The results of endoscopic and open myomectomy are similar; thus, endoscopic treatment is the recommended approach due to its advantages in patient's postoperative course.

  4. Uterine fibroid: a review.

    Science.gov (United States)

    Akinyemi, B O; Adewoye, B R; Fakoya, T A

    2004-01-01

    Uterine fibroid is a benign tumour of uterine smooth muscle. The purpose of this review is to bring to light the current spectra of presentation and management status of this benign and very important cause of menstrual and fertility disturbance in African women and the Black race in general. This is especially so with the trivialization of its aetological factors and treatment by claims from alternative medical practitioners. This review, therefore sought to document what is currently known about the condition and what could possibly be done to achieve better results in its management. Literature on the subject above was reviewed using manual library search, electronic books such as CD-ROMS and journals articles published by various local and international authors on the subject; it also included internet search on relevant aspects of the topic. Fibroid is the commonest benign tumour of the female genital tract, it contributes about 70 to 80% of new growths in the female genital tracts, it is a cause of significant morbidity in women of reproductive age group and when complicated could be a significant cause of mortality. Spectrum of presentation mainly involves disturbance of menstruation, reduction in fertility, pressure and obstructive symptoms and rarely malignant presentations. When recognized early effective conservative and definitive therapies are available to offer relief for women and to make their menstrual and reproductive life more meaningful. From the literature reviewed, it was obvious that the subject of uterine fibroid is still not fully exhausted and there were a lot of research questions waiting to be answered on the aetiopathogenesis of the disease. There is also the need to fashion out better treatment alternatives that will reduce morbidity in the process of managing the patient as well as those that will further enhance reproductive potentials after treatment.

  5. A rare case of cervical fibroid presenting as retained placenta with postpartum hemorrhage

    Directory of Open Access Journals (Sweden)

    Meenakshi Chowdhury

    2015-04-01

    Full Text Available Fibroids during pregnancy are often asymptomatic but sometimes may lead to various complications and unusual presentations. We are reporting an unusual case of cervical fibroid during pregnancy that presented as retained placenta with postpartum hemorrhage following a full term normal vaginal delivery. [Int J Reprod Contracept Obstet Gynecol 2015; 4(2.000: 505-507

  6. Uterine fibroids: clinical manifestations and contemporary management.

    Science.gov (United States)

    Doherty, Leo; Mutlu, Levent; Sinclair, Donna; Taylor, Hugh

    2014-09-01

    Uterine fibroids (leiomyomata) are extremely common lesions that are associated with detrimental effects including infertility and abnormal uterine bleeding. Fibroids cause molecular changes at the level of endometrium. Abnormal regulation of growth factors and cytokines in fibroid cells may contribute to negative endometrial effects. Understanding of fibroid biology has greatly increased over the last decade. Although the current armamentarium of Food and Drug Administration-approved medical therapies is limited, there are medications approved for use in heavy menstrual bleeding that can be used for the medical management of fibroids. Emergence of the role of growth factors in pathophysiology of fibroids has led researchers to develop novel therapeutics. Despite advances in medical therapies, surgical management remains a mainstay of fibroid treatment. Destruction of fibroids by interventional radiological procedures provides other effective treatments. Further experimental studies and clinical trials are required to determine which therapies will provide the greatest benefits to patients with fibroids.

  7. Optimal design of mid-long term planning method for oil recovery engineering%采油工程中长期规划方法的优化设计

    Institute of Scientific and Technical Information of China (English)

    陈萍

    2015-01-01

    The mid and long-term planning for oil production plays an important role in oil quality,production safety and yield.It is optimized based on quality control PDCA mode to improve quality management system of the production engineering and meet the requirements of new planning so as to ensure that overall planning in smooth and efficient operation.%采油工程中长期规划对采油质量、采油安全、采油产量等都有重要影响,基于PDCA质量控制模式,对采油工程中长期规划方法进行优化设计,能有效完善采油工程的质量管理体系,以迎合新时期采油工程规划的应用需求,确保采油工程整体规划的顺利、高效运行.

  8. Analysis of mid-long term clinical efficacy and complications of Bryan artificial cervical disc replacement%Bryan人工颈椎椎间盘置换术后中长期临床疗效及相关问题分析

    Institute of Scientific and Technical Information of China (English)

    蒋涛; 任先军; 王卫东; 初同伟; 李长青

    2011-01-01

    目的 探讨Bryan人工颈椎椎间盘置换术(artificial cervical disc replacement,ACDR)治疗颈椎椎间盘突出症的中长期临床疗效及并发症发生情况.方法 回顾分析13例颈椎椎间盘突出症患者,采用Bryan ACDR治疗,单节段11例,双节段2例,共置换了15个节段.术后定期随访,依照Odom评级和日本骨科学会(Japanese Orthopaedic Association,JOA)评分评定临床疗效和神经功能改善情况,通过影像学资料观察假体位移、假体周围骨吸收、异位骨化、假体活动度及颈椎生理曲度变化.结果 经过5年以上的随访,患者神经症状有明显缓解,Odom评级临床优良率达到92.3%,JOA评分由术前的11.6分增加到的15.6分.术后X线片示假体稳定,没有出现假体前后位移>2mm.术后1例出现自发性融合;1例在置换节段上位椎体前下缘有明显骨吸收,接近2.5mm,并伴椎体后缘的异位骨化.末次随访时置换假体活动度平均为9.2°,邻近节段活动度与术前相当.结论 通过5~7年的中长期随访,Bryan ACDR术治疗颈椎椎间盘突出症具有较好的临床疗效,并发症少,安全可靠.%Objective To evaluate the mid-long term clinical efficacy and complications of Bryan artificial cervical arthro-plasty replacement (ACDR) for treatment of cervical disc herniation. Methods Thirteen cases of cervical disc herniation were retrospectively analyzed. A total of 15 sets of Bryan cervical disc prosthesis were implanted into 13 cases, including single level disc replacement in 11 cases and bi-level in 2 cases. During follow-up, the clinical efficacy and neurological function were evaluated by Odom's criteria and Japanese Orthopaedic Association (JOA)score; the mobility, resorption, heteropic ossification, physiological lordosis and range of motion of the implanted and adjacent segment were observed on dynamic radiograph. Results After more than 5 years of follow-up, all cases showed significant improvement in neurological

  9. Laparoscopic power morcellation of presumed fibroids.

    Science.gov (United States)

    Brolmann, Hans A; Sizzi, Ornella; Hehenkamp, Wouter J; Rossetti, Alfonso

    2016-06-01

    Uterine leiomyoma is a highly prevalent benign gynecologic neoplasm that affects women of reproductive age. Surgical procedures commonly employed to treat symptomatic uterine fibroids include myomectomy or total or sub-total hysterectomy. These procedures, when performed using minimally invasive techniques, reduce the risks of intraoperative and postoperative morbidity and mortality; however, in order to remove bulky lesions from the abdominal cavity through laparoscopic ports, a laparoscopic power morcellator must be used, a device with rapidly spinning blades to cut the uterine tissue into fragments so that it can be removed through a small incision. Although the minimal invasive approach in gynecological surgery has been firmly established now in terms of recovery and quality of life, morcellation is associated with rare but sometimes serious adverse events. Parts of the morcellated specimen may be spread into the abdominal cavity and enable implantation of cells on the peritoneum. In case of unexpected sarcoma the dissemination may upstage disease and affect survival. Myoma cells may give rise to 'parasitic' fibroids, but also implantation of adenomyotic cells and endometriosis has been reported. Finally the morcellation device may cause inadvertent injury to internal structures, such as bowel and vessels, with its rotating circular knife. In this article it is described how to estimate the risk of sarcoma in a presumed fibroid based on epidemiologic, imaging and laboratory data. Furthermore the first literature results of the in-bag morcellation are reviewed. With this procedure the specimen is contained in an insufflated sterile bag while being morcellated, potentially preventing spillage of tissue but also making direct morcellation injuries unlikely to happen.

  10. Dealing with uterine fibroids in reproductive medicine.

    Science.gov (United States)

    Gambadauro, P

    2012-04-01

    Women who wish to conceive are nowadays more likely to present with uterine fibroids, mainly because of the delay in childbearing in our society. The relationship between uterine fibroids and human reproduction is still controversial and counselling patients might sometimes be challenging. This paper is to assist those involved in the management of patients of reproductive age presenting with uterine fibroids. The interference of fibroids on fertility largely depends on their location. Submucous fibroids interfere with fertility and should be removed in infertile patients, regardless of the size or the presence of symptoms. Intramural fibroids distorting the cavity reduce the chances of conception, while investigations on intramural fibroids not distorting the cavity have so far given controversial results. No evidence supports the systematic removal of subserosal fibroids in asymptomatic, infertile patients. Myomectomy is still the 'gold standard' in fibroid treatment for fertility-wishing patients. In experienced hands, hysteroscopic myomectomy is minimally invasive, safe, and effective. Abdominal and laparoscopic myomectomy might be challenging, but potential risks could be reduced by new strategies and techniques.

  11. Mid-long-term Clinical Results and Hemodynamic Evaluation of Aortic Valve Replacement with 17 mm St. Jude Medical Regent Valve%17 mm St.Jude Regent瓣术后中远期临床效果和在体血流动力学评价

    Institute of Scientific and Technical Information of China (English)

    刘勇; 张尔永; 方智; 古君; 钱宏

    2013-01-01

    Objective To investigate the mid-long-term clinical results of aortic valve replacement with 17 mm St. Jude medical regent valve with hemodynamic evaluation including the measurement of effective orifice area, the occurrence of prosthesis-patient mismatch (PPM) and its affect on heart function. Methods There were 44 patients accepted aortic valve replacement with 17 mm St. Jude medical regent valve because of small aortic annulus. Before the operation and during the postoperative follow-up, color doppler echocardiography was used to measure the hemodynamic parameters, such as left ventricular mass (LVmass), effective orifice area (EOA) and effective orifice area index (EOAI), etc.. Results Transthoracic echocardiographic data were obtained from 39 of 44 patients (88. 6%)at 12-55 months after surgery. One (2. 27%) died of heart failure in 1 year. According to the current standard of PPM (EOAI≤0. 85 cm2/m2) , 33 cases (82. 1%) had PPM, 13 cases (30. 8%) had severe PPM with an EOAI ≤0. 65 cm2/m2. After the operation, there were significant decreases in LVAo-PG (19 ± 8) mmHg and left ventricular mass index (LVmass I ) (86. 6 ± 23. 3) g/m2(P<0. 05). The assessment for physical capacity according to NYHA classification: 41 patients improved to class II or better and 2 patients improved to class Ⅲ (P<0. 05). Conclusion The patients with small aortic annulus may obtain satisfactory clinical results after AVR with 17 mm St. Jude medical regent valve, PPM seems not affect the mid-long-term results.%目的 观察17 mm St.Jude Regent机械瓣置入人体后中远期临床效果,测量其有效瓣口面积,评价是否发生瓣膜-患者不匹配(prosthesis-patient mismatch,PPM)现象,并探索PPM现象对术后患者心功能的影响.方法 44例心脏瓣膜病患者接受二尖瓣及主动脉瓣置换术,所有患者因主动脉瓣环小而置入17 mm St.Jude Regent机械瓣.对该组患者进行随访研究,分别于术前及术后12~55月,运用心

  12. A retrospective comparison of microwave ablation and high intensity focused ultrasound for treating symptomatic uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Wen-Peng, E-mail: zwp215@163.com; Han, Zhi-Yu, E-mail: hanzhiyu301@hotmail.com; Zhang, Jing, E-mail: zjbch@sina.com; Liang, Ping, E-mail: liangping301@hotmail.com

    2015-03-15

    Highlights: •Both HIFU and PMWA are thermal ablation techniques and they all provide safe and reliable alternative treatment methods for uterine fibroids. •However, whether there are obvious difference between these two kinds of approaches in improving symptom, treatment time, ablation rate, regression rate and adverse events, until now, there are no clinical trials which have been performed to compare the therapeutic effects of HIFU and PMWA. •In this research, we retrospectively compare the results of these two treatment methods. •To our knowledge, our study is the first directly comparing long-term outcome after PMWA and HIFU in patients with uterine fibroids. -- Abstract: Objectives: To retrospectively compare the effectiveness and safety of percutaneous microwave ablation (PMWA) and ultrasound-guided high-intensity focused ultrasound (USgHIFU) for treating symptomatic uterine fibroids. Methods: Seventy-three women with symptomatic uterine fibroids who met the inclusion criteria were enrolled in our study from September 2012 to December 2013. Thirty-one patients with forty uterine fibroids underwent PMWA, and forty-two patients with fifty-one uterine fibroids underwent USgHIFU. A contrast-enhanced MRI was performed before and after treatment, and all patients were followed up for 6 months. Assessment endpoints included symptom severity scores (SSS), treatment time, ablation rate, fibroid regression rate and adverse events. Results: The mean age of the patients in our study was 35.4 ± 6.2 years (range, 21–49 years), and the median volume of uterine fibroids was 95.7 cm{sup 3} (60.3–131.5 cm{sup 3}). The ablation rate of uterine fibroids was 79.8 ± 18.2% and 77.1 ± 14.9% in the PMWA group and the USgHIFU group, respectively, and showed no significant difference between the groups. Changes in SSS after PMWA were similar in the PMWA group (47.7 pre-treatment vs. 29.9 post-treatment) and USgHIFU group (42.1 pre-treatment vs. 24.6 post-treatment). The

  13. Leiomyosarcoma: a rare complication of uterine fibroid

    Directory of Open Access Journals (Sweden)

    Shazia Parveen

    2014-04-01

    Full Text Available Uterine sarcomas are rare tumours of mesodermal origin. Malignant change occurring in uterine fibroid is termed as leiomyosarcoma. They constitute around 2-6 % uterine malignancies and 25-36% of uterine sarcomas1. The tumour is common in women between the age group 40-50 years. It has an aggressive course and usually metastasis goes to the lungs. The prognosis for women with uterine sarcoma primarily depends on the extent of disease at the time of diagnosis and mitotic index3. Women with tumor size >5 cm in maximum diameter have poor prognosis. These tumours should be diagnosed and managed with no delay and must be followed vigilantly as the rate of recurrence and metastasis is very high. [Int J Reprod Contracept Obstet Gynecol 2014; 3(2.000: 486-487

  14. [GnRH analogues for the treatment of fibroids].

    Science.gov (United States)

    Murillo, Ester Ortiz; Cano, Antonio

    2013-07-01

    Uterine fibroids are benign tumors that are very common in women and may present significant symptoms in 20%-50% of cases. When they require action, their traditional management has been surgery (hysterectomy or fibroidectomy); however medical alternatives have been proposed, given that surgery is associated with a certain morbidity and mortality and involves healthcare costs. Within the pharmacological management of uterine fibroids, GnRH analogues are the best known and most commonly used drugs, although their indications are limited by the side effects associated with long-term treatment. Their primary indication is based on preoperative treatment (to hysterectomy or fibroidectomy) and in selected cases of patients close to menopause or who want more conservative management. These analogues are able to significantly reduce the uterine volume, the size of the fibroid and their accompanying symptoms. Their main disadvantage, however, lies in the reversibility of their effect when treatment is discontinued, along with the side effects associated with hypoestrogenism, such as climacteric symptoms and loss of bone mass. "Add-back" therapies, which associate low-dose estrogens to aGnRH, allow for extended use thanks to decreased side effects without affecting the benefits. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  15. Rare case of giant broad ligament fibroid with myxoid degeneration

    Directory of Open Access Journals (Sweden)

    R R Godbole

    2012-01-01

    Full Text Available Giant fibroids are known to arise from the uterus, although very rarely from extra-uterine sites. Among extra-uterine fibroids, broad ligament fibroids generally achieve enormous size and generally present with pressure symptom like bladder and bowel dysfunction. Myxoid degeneration is a rare complication of benign fibroid, where presence of cystic changes mimics the metastatic malignant ovarian tumor. We report a case of true broad ligament fibroid measured about 13 kg. This case is reported for its rarity and the diagnostic difficulties in differentiating malignant ovarian tumor and benign fibroid with myxoid degeneration.

  16. [Hormonal treatments for hemorrhaging secondary to fibroids. An alternative or complement to surgery?].

    Science.gov (United States)

    Cancelo Hidalgo, María Jesús

    2013-07-01

    The main objective of treatment in women with uterine fibroids is the control of associated symptoms such as abnormal uterine bleeding, pain and pressure. Although the cost and potential adverse effects of the long-term use of medical treatment may limit its use for a long time, this alternative should be considered before indicating surgical treatment. At present, we have a considerable variety of drugs that, although not specific treatments for fibroids, may be used for the short to medium-term management of bleeding; however, we have still not found an alternative that eliminates the need for invasive treatments. Further research in this field is therefore warranted. Given the heterogeneity of fibroids and the lack of effective treatments in controlling their growth, the identification of signals that stimulate the onset and growth of these fibroids opens doors to the development of new therapies. In the future we may be able to differentiate classes of fibroids by molecular techniques and thereby implement specific treatments that control their development and their associated symptoms. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  17. The mid-long term effect of conversion from cyclusporine to tacrolimus in patients with kidney transplantation%肾移植受者将环孢素A转换为他克莫司治疗的三年疗效分析

    Institute of Scientific and Technical Information of China (English)

    祝藩原; 曾力; 温燕; 赵闻雨; 陈瑜; 郑鳕洋; 王立明; 朱有华

    2011-01-01

    Objective To verify the efficacy and safety of conversion from cyclosporine (CsA) to tacrolimus (Tac) in renal transplant recipients. Methods The clinical data of conversion from CsA to Tac in renal transplant recipients were retrospectively analyzed. In 97 patients undergoing kidney transplantation, there were 62 cases of chronic allograft nephropathy (CAN), 21 cases of refractory renal allograft rejection, 8 cases of hepatic impairment, and 6 cases of gingival overgrowth and hirsutism. The patients were followed up with renal function, hepatic function, blood fat, pressure,glucose,acute rejection incidence, patients/kidney survival rate,and adverse drug reaction for 3 years.Results The renal function of patients with CAN and refractory acute rejection was greatly improved after conversion from CsA to Tac treatment at the first year (P<0. 05) ,and steady at the 2nd or 3rd year. The conversion treatment could greatly improve the hepatic function of patients with dysfunction of liver, improve the gum hypertrophy and hypertrichosis results from CsA. The 1- and 3-year patients/kidney survival rate after conversion from CsA to Tac was 100 %/97. 9 % and 100 %/92. 8 %, respectively. The conversion treatment showed a significantly lower degree of plasma cholesterol, low density lipoprotein, triglyceride, and blood pressure (P < 0.05). Incidence of pathoglycemia, diarrhea or anepithymia,and tremor after conversion treatment was 13.4 % (13/97),2. 1% (2/97) and 5. 2 % (5/97),respectively. There were no serious pulmonary infection and tumor during the observation period. Conclusion The mid-long term effect of conversion from CsA to Tac in patients with kidney transplantation is safe and effective.%目的 评价肾移植受者将环孢素A(CsA)转换为他克莫司(Tac)治疗的有效性和安全性。方法 回顾将CsA转换为Tac治疗的97例肾移植受者的资料,转换治疗的原因分别为慢性移植肾肾病62例,难治性排斥反应21

  18. Knowledge of, Perception of, and Attitude towards Uterine Fibroids among Women with Fibroids in Lagos, Nigeria

    Directory of Open Access Journals (Sweden)

    M. A. Adegbesan-Omilabu

    2014-01-01

    Full Text Available Objectives. The study was to assess the level of knowledge of, perception of, and attitude towards uterine fibroids among women diagnosed with the condition. Methods. It is a cross-sectional descriptive study carried out among women diagnosed as having uterine fibroids in two gynaecological clinics in Lagos, Nigeria. Eligible women were recruited and a structured interviewer-administered questionnaire was used to collect the required information. Statistical analysis of data was done using EPI Info 2008. Results. Knowledge of fibroids was reported in 98.6% of the respondents and the information on uterine fibroids was obtained from radio, parents/relatives, health workers, and television in 29%, 27.3%, 18.7%, and 18.3%, respectively, by the respondents. Most of the women believed that being black, being nulliparous, or having positive family history predisposes women to having uterine fibroids. Up to 69.0% of the respondents believed that fibroid is a spiritual problem and many thought it requires spiritual healing. Fear of complications of surgery keeps most sufferers away from the hospital until fibroids become advanced or associated with complications. Conclusion. Awareness of uterine fibroids is high, but correct knowledge on aetiology and proper treatment is low. Intensive enlightenment of the populace using the mass media by trained personnel is recommended.

  19. Less-Invasive Fibroid Treatment May Be 'Under-Used'

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163933.html Less-Invasive Fibroid Treatment May Be 'Under-Used' But ... hysterectomy remains much more common compared with a less-invasive procedure called embolization. Fibroids are non-cancerous ...

  20. Uterine artery embolisation for symptomatic fibroids: the University of Malaya Medical Centre experience

    Science.gov (United States)

    Subramaniam, RN; Vijayananthan, A; Omar, SZ; Nawawi, O; Abdullah, BJJ

    2010-01-01

    Background: Transcatheter uterine artery embolisation (UAE) for the treatment of symptomatic fibroids has been performed in several centres in the United States, Western Europe and Asia with promising results. This study reports the authors' experience with UAE at the University Malaya Medical Centre. Method: Fifty women with symptomatic uterine fibroids who declined surgery were treated by transcatheter UAE. The uterine arteries were selectively catheterised and embolised with polyvinyl alcohol particles. Post-procedure analgesia was administered via patient-controlled analgesic pump. The patients were followed up at an interval of 6/12 clinically and with MRI. Results: Transcatheter UAE was performed on all 50 patients with no major complications. 49 patients had both uterine arteries embolised while 1 patient had only the right uterine artery embolised on account of hypoplasia of the left uterine artery due to previous myomectomy. The mean hospital stay was 3.5 days (range, 2 to 7). At a mean follow-up of 24/52, all patients reported improvements in their presenting symptoms. Objective improvement in terms of reduction of uterine and fibroid sizes was determined on MRI. One patient, who initially responded with a decrease in uterine and dominant fibroid size, became symptomatic (menorrhagia) after 6 months and subsequent endometrial sampling revealed cystic glandular hyperplasia for which total abdominal hysterectomy was performed. Two other patients had no change in symptoms and after hysterectomy, the pathology revealed concurrent adenomyosis. Another 2 patients with cervical fibroids were treated with hysterectomy as there was no gross reduction in the size of fibroid following UAE. Overall, 90% of the patients had dramatic improvement of anaemia and symptoms at 1 year follow-up. Conclusion: Out of the 50 patients, 17 patients had total disappearance of their fibroids and 28 patients had more than 50% reduction in the size of fibroids after 1 year. 5 patients

  1. 有晶状体眼后房型人工晶状体植入矫正高度近视的中远期疗效评价%Mid-long term follow-up results in correction of extreme mvopia by posterior chamber phakic intraocular lens

    Institute of Scientific and Technical Information of China (English)

    周天安; 沈晔; 汪阳; 夏建华

    2012-01-01

    Objective To evaluate the mid-long term stability and safety of posterior chamber phakic intraocular lens (ICL) implantation for the correction of extreme myopia. Methods This retrospective study included 993 eyes of 498 patients received ICL implantation from June 1996 to December 2008.Multivariate analysis and variance analysis were used to evaluate the stability of the results and to identify risk factors of the complications. Results Successful implantation was achieved in all patients.Spherical equivalent(SE) was (16.23 ±4.12,mean ±SD) D before the operation and ( -0.92 ± 1.22) D at the last examination. Intraocular pressure was (13.58 ± 2.93) mm Hg( 1 mm Hg =0.133 kPa)preoperatively which was ( 13.90 ± 3.01 ) mm Hg at the last examination. There was no statistical significance in follow-up( t =0.44 ~1.30,P > 0.05 ).Endothelial cell density was (2858.21 ± 395.13 )/mm2 before the operation and (2567.19 ± 423.45 ) /mm2 at last examination.Pupillary block glaucoma occurred in 2 eyes (0.2% ) at two hours and 1 eye (0.1% ) at one month after the operation.Three eyes developed anterior cataracts between 6 months to 1 year after ICL implantation and another 2 eyes subcapsular opacification at semi-peripheral regions occurred 4 years after the operation,and was not related with age,SE and vaults (F=2.42,1.98,0.81,P>0.05). Macular puckers were found in 5 eyes (0.5%) 1 year postoperatively,including 2 eyes developed choroidal neovascularization and received PDT,best corrected visual acuity lost more than 2 lines.Retinal detachment occurred in 2 eyes at 1.5 years after the operation.Acute iritis happened in 1 eye (0.1% ) and chronic iritis in 1 eye (0.1% ) which combined with slight pupil distortion and elevation of intraocular pressure.Iris stroma atrophy and pupil distortion were found in 2 eyes (0.2% ).Conclusion Correction of high myopia by ICL implantation is a safe procedure and the results are stable.%目的 总结有晶状体眼后房

  2. Successful Pregnancy after Treatment with Ulipristal Acetate for Uterine Fibroids

    OpenAIRE

    Javier Monleón; Alicia Martínez-Varea; Daniela Galliano; Antonio Pellicer

    2014-01-01

    This case report presents a clinical pregnancy after ulipristal acetate (UA) to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5 mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometrial ...

  3. Ulipristal acetate: a novel option for the medical management of symptomatic uterine fibroids.

    Science.gov (United States)

    Talaulikar, Vikram S; Manyonda, Isaac T

    2012-08-01

    Fibroids, the most common tumor in women of reproductive age, impact negatively on women's health and quality of life, and have significant cost implications for their management. The current mainstay treatments are surgical (myomectomy and hysterectomy) and more recently radiological (UAE and focused ultrasound surgery). Hysterectomy is curative but precludes future fertility, whereas the impact of the other treatments on reproduction is uncertain. With women in Western societies deferring childbearing to their 30s and 40s, when fibroids are most symptomatic, there is a pressing need for a uterus-sparing medical therapy that is cheap, effective, and enhances reproductive potential. Serendipity and meticulous translational research has shown that progesterone augments fibroid proliferation, raising the possibility that progesterone receptor modulators could inhibit fibroid growth; this research has culminated in the emergence of ulipristal acetate (UA), a first-in-class, oral selective progesterone receptor modulator (SPRM) that has successfully completed phase III clinical trials. It has been licensed in Western Europe for short-term clinical use prior to surgery, and has shown efficacy with a significant reduction in uterine bleeding, fibroid volume, and improved quality of life, without the side effects associated with other medications such as gonadotropin-releasing hormone (GnRH) agonists. As with all new medicines, there are concerns surrounding UA, not least its effect on the endometrium and the long-term impact on general health and reproduction. Research to date has tended to be industry led, and therefore, there is a need for researcher/clinician-led studies to address the wider issues concerning SPRMs. UA may not turn out to be the "Holy Grail" of medical therapy in the treatment of symptomatic uterine fibroids, but it has rightly given cause for a huge optimism. Further laboratory and clinical research into PRMs and related compounds will no doubt lead

  4. Pregnancy outcome in patients with fibroid

    Directory of Open Access Journals (Sweden)

    Antima Kirtikumar Maliwad

    2014-06-01

    Full Text Available Background: Fibroids are benign smooth muscle cell tumour of the uterus. In some patients of pregnancy associated with fibroid, it does not affect the outcome of pregnancy. On the other hand, various complications have been reported. Objective of current study was to assess the prevalence and obstetric complications of fibroid during pregnancy and it management. Methods: This was a prospective study. The study was conducted at tertiary care centre, obstertrics and gynecology department over a period of nine months September 2013 to May 2014. Total 17 pregnant patients with >3 cm fibroid were included in the study. They were followed during antenatal period. Maternal age, parity, size of fibroid, complications during pregnancy, labour, and delivery, mode of delivery and indications of cesarean section were noted. Results: Incidence of fibroid during pregnancy was 0.4%. Out of 17 patients, majority 9 (52.9% were between 26-30 years of age group, majority 7 (41.1% were diagnosed between 21-28 weeks and 14 (82.3% were multigravidas. Normal vaginal delivery occurred in 3 (20%, while 12 (80% delivered by cesarean section. There were 8 (47% patients who had no complication whereas 9 (52.9% had some complication. Pain was present in 7 (41.1%. PROM and preterm labour was present in 3 (17.6% and 2 (11.7% respectively. Abortion and IUD occurred in 2 (11.7% and in 1 (5.8% respectively. LBW and IUGR was present in 5 (29.4% and 3 (17.6% respectively. PPH was present in 6 (35.2%. Antenatal myomectomy performed in 1 (5.8% and myomectomy at cesarean section performed in 2 (11.7%. Blood transfusion was given to 8 (47% patients. Conclusions: Pregnant patients who have fibroids are to be carefully screened in the antenatal period, so as to have a regular follow up. The wide spread use of ultrasonography has facilitated diagnosis and management of fibroids in pregnancy. The site and size of fibroid is very important to predict its effect on the pregnancy. In

  5. An evidence-based approach to hormonal therapies for premenopausal women with fibroids.

    Science.gov (United States)

    Lethaby, Anne E; Vollenhoven, Beverley J

    2008-04-01

    Ovarian steroids, particularly oestrogen, are important factors for fibroid growth. This has provided a rationale for the investigation of hormonal therapies for women with fibroids. This chapter will assess the role of hormonal therapies for pre-menopausal women with fibroids. A comprehensive search of MEDLINE and EMBASE was undertaken in December 2006. Twenty-nine relevant randomized controlled trials and two systematic reviews were found. The included studies assessed gonadotrophin-releasing hormone analogues (GnRHa) alone, GnRHa plus add-back (with either progestagen, tibolone, combined oestrogen and progestagen, or raloxifene) and GnRHa given for at least 3 months prior to surgery for fibroids. Two trials assessed the effects of raloxifene alone. One trial assessed the effects of low-dose mifepristone, and a pilot study assessed the role of the selective progesterone receptor modulator, asoprisinil. GnRHa reduce fibroid and uterine volume and heavy bleeding but are associated with menopausal symptoms and bone loss, which limit long-term use. There is some evidence that add-back therapy, either progestagen, tibolone, combined oestrogen and progestagen, or raloxifene, can reduce the menopausal symptoms associated with GnRHa and/or loss of bone density, but there is insufficient good-quality research to make definitive conclusions. GnRHa given for at least 3 months before fibroid surgery improve pre-operative haemoglobin concentration and haematocrit, reduce uterine and pelvic symptoms, and reduce the rate of vertical incisions during laparotomy. Women undergoing hysterectomy are more likely to have a vaginal than an abdominal procedure. Limited evidence suggests that raloxifene may be useful in older premenopausal women with lower concentrations of background oestradiol. Limited short-term evidence of two progestogenic therapies indicates that low-dose mifepristone may improve quality of life and bleeding in the short term, and asoprisinil may improve bleeding

  6. Uterine artery embolization to treat uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Machan, L.; Martin, M. [Univ. of British Columbia Hospital, Dept. of Radiology, Vancouver, BC (Canada)

    2001-06-01

    The first reported application of uterine artery embolization, in 1979, was to treat life-threatening hemorrhage after a failed hysterectomy. Since then, uterine artery embolization has been used very successfully to control acute or delayed post-partum hemorrhage, post-surgical hemorrhage and hemorrhage from ectopic pregnancy, to treat uterine arteriovenous malformations and as prophylaxis before high-risk surgery, such as cesarean delivery in women with placenta previa. In contrast to these proven but underutilized applications, uterine embolization for fibroids has, in a short time, achieved significant notice in the lay press and is being widely offered. Ravina and colleagues, first reported uterine fibroid shrinkage after embolization for the treatment of acute bleeding. Since then, his group has performed over 100 procedures with up to a 6-year follow-up. The cumulative clinical success rate for the treatment of abnormal uterine bleeding due to fibroids is reported to be approximately 85% and for treatment of pain or pressure symptoms, about 75%. Six-month follow-up sonography reveals an average reduction of fibroid size of approximately 40%. However, to date, no studies have compared patients who undergo embolization with a nontreatment cohort or with surgical intervention. (author)

  7. Diffusion-weighted imaging properties of uterine fibroids pre- and post-uterine fibroid embolisation

    Energy Technology Data Exchange (ETDEWEB)

    Kirpalani, Anish, E-mail: kirpalania@smh.ca [Department of Medical Imaging, University of Toronto, St. Michael’s Hospital, 30 Bond Street, 3CC, Toronto, ON M5B 1W8 (Canada); Chong, Jennifer [Department of Medical Imaging, University of Toronto, St. Michael’s Hospital, 30 Bond Street, 3CC, Toronto, ON M5B 1W8 (Canada); Yang, Natalie [Department of Radiology, Austin Health, Heidelberg, Victoria 3084 (Australia); Jenkins, Sarah J. [Department of Radiology, Memorial University of Newfoundland, St. John’s, NL A1B 3V6 (Canada); Nisenbaum, Rosane [Centre for Research on Inner City Health, the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Dalla Lana School of Public Health, University of Toronto, 30 Bond Street, Toronto, ON M5B 1W8 (Canada); Prabhudesai, Vikramaditya; Anthwal, Shalini; Colak, Errol [Department of Medical Imaging, University of Toronto, St. Michael’s Hospital, 30 Bond Street, 3CC, Toronto, ON M5B 1W8 (Canada)

    2014-09-15

    Highlights: • Change in ADC and contrast enhancement of uterine fibroids following UFE was studied. • ADC of fibroids rises post-UFE. Previous studies assessing this change have conflicting results. • ADC rise post-UFE is associated with degree of loss of contrast enhancement. • ADC measurement using DWI is not yet a proven replacement for GBCA-enhanced MRI. - Abstract: Objective: To determine the change in apparent diffusion coefficient (ADC) of uterine fibroids following uterine fibroid embolisation (UFE), and if the ADC change correlates with either volume loss or degree of contrast enhancement post-UFE. Materials and methods: This study was approved by our institutional review board with waiver of consent. The pelvic MRI examinations, including diffusion-weighted MRI (DWI) using 4 b-values, of 50 consecutive patients prior to and 6 months post-UFE were analyzed. The volume, ADC and amount of enhancement were calculated for each fibroid both pre- and post-UFE. The percent residual enhancement for each fibroid was categorized as either: no (0–1%) residual enhancement or residual (>1%) enhancement. Statistical analysis compared ADC, enhancement and volume for each fibroid pre- and post-UFE using paired t-tests and Pearson correlation coefficients. Results: The mean ADC of all (n = 88) fibroids pre-UFE was 1.30 ± 0.20 × 10{sup −3} mm{sup 2}/s, and increased to 1.68 ± 0.24 × 10{sup −3} mm{sup 2}/s post-UFE (p < 0.0001). Lower pre-UFE ADC correlated with greater ADC change post-UFE (r = −0.50; p < 0.0001). There was no correlation between ADC change and volume change post-UFE (r = 0.07; p = 0.59). However, fibroids with no residual enhancement post-UFE had larger ADC change than those with residual enhancement (p = 0.003). Conclusion: The ADC of fibroids rises post-UFE. ADC change post-UFE is associated with the degree of loss of enhancement and may therefore be valuable in predicting response to treatment in pre-procedural counseling.

  8. Radiofrequency Ablation for Treatment of Symptomatic Uterine Fibroids

    Directory of Open Access Journals (Sweden)

    Siân Jones

    2012-01-01

    Full Text Available The use of thermal energy-based systems to treat uterine fibroids has resulted in a plethora of devices that are less invasive and potentially as effective in reducing symptoms as traditional options such as myomectomy. Most thermal ablation devices involve hyperthermia (heating of tissue, which entails the conversion of an external electromagnetic or ultrasound waves into intracellular mechanical energy, generating heat. What has emerged from two decades of peer-reviewed research is the concept that hyperthermic fibroid ablation, regardless of the thermal energy source, can create large areas of necrosis within fibroids resulting in reductions in fibroid volume, associated symptoms and the need for reintervention. When a greater percentage of a fibroid's volume is ablated, symptomatic relief is more pronounced, quality of life increases, and it is more likely that such improvements will be durable. We review radiofrequency ablation (RFA, one modality of hyperthermic fibroid ablation.

  9. INTERESTING CASES OF DIFFERENT TYPES OF CERVICAL FIBROIDS

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    Narmadha

    2014-05-01

    Full Text Available The incidence of cervical fibroids is 0.5-1%. It is usually single; they are usually confined to supravaginal portion of the cervix. Rarely it becomes submucous and polypoidal. So it is usually subserous or interstitial. It can be anterior, posterior or central in position. We had different types of cervical fibroids of which we will describe a few. Usually cervical fibroids cause infertility, difficulty in labor, infections, metrorrhagia, menorrhagia, constipation, retention of urine and dyspareunia. The cervical fibroid distorts the shape of cervix and grows bigger. It pushes the uterus upward giving the appearance of lantern of Saint Paul’s dome in a case of a central cervical fibroid. Most of the patients in the reproductive age get admitted for menorrhagia due to fibroid. Its growth is dependent on estrogen. It does not grow after menopause

  10. The mid-long-term influence of open-door laminoplasty with reconstruction of the posterior cervical ligamentous complex on cervical physiological curvature and range of motion%保留颈后方韧带复合体单开门椎管扩大成形术后其颈椎生理曲度及活动范围的中远期随访

    Institute of Scientific and Technical Information of China (English)

    王磊; 王伟; 张永兴; 任龙喜

    2014-01-01

    Objectives: To study the mid-long-term influence of open-door laminoplasty with reconstruction of the posterior cervical ligamentous complex on cervical physiological curvature and range of motion . Meth-ods: From January 2005 to January 2008, 20 patients undergoing open-door laminoplasty with reconstruction of the posterior cervical ligamentous complex were reviewed retrospectively, the series consisted of 12 males and 8 females, aged 37-68 years(average, 52 years). The JOA score, alignment of the cervical spine and the ROM of the cervical spine were analyzed before and after operation respectively. Results: 20 patients were followed-up for a mean time of 7 years(range, 5-8 years). The mean JOA score was 9.5(7-13) before opera-tion. At final follow up, the mean JOA score was 14.0(9-17) and the recovery rate was 52%, which showed significant improvement(P0.05) compared with the preoperative(29°); and 7 degrees(5.5-19 degrees) for flexion, which showed significant difference(P0.05), and flexion position averaged 7°(5.5°-19° ), showing significant difference compared with the preoperative (16° , P<0.05). Replanted spinous process and the float laminae got bony fusion. No door re-closure was observed, and good vertebral canal maintaining was maintained. Conclusions: After open-door laminoplasty, the procedure of reconstruction of the posterior cervical ligamentous complex and the insertion of extensor to treat CSM will be helpful on maintaining the cervical physiological curvature, but it reduces the range of motion through the mid-long-term observation.%目的:观察保留颈后方韧带复合体重建伸肌附着点单开门椎管扩大成形术治疗脊髓型颈椎病对颈椎生理曲度、活动范围的中远期影响。方法:2005年1月~2008年1月采用保留颈后方韧带复合体联合重建伸肌附着点单开门椎管扩大成形术治疗脊髓型颈椎病20例患者,其中男性12例,女性8例,年龄37~68岁,平均52岁。比较

  11. Uterine fibroid tumors: diagnosis and treatment.

    Science.gov (United States)

    Evans, Patricia; Brunsell, Susan

    2007-05-15

    The incidence of uterine fibroid tumors increases as women grow older, and they may occur in more than 30 percent of women 40 to 60 years of age. Risk factors include nulliparity, obesity, family history, black race, and hypertension. Many tumors are asymptomatic and may be diagnosed incidentally. Although a causal relationship has not been established, fibroid tumors are associated with menorrhagia, pelvic pain, pelvic or urinary obstructive symptoms, infertility, and pregnancy loss. Transvaginal ultrasonography, magnetic resonance imaging, sonohysterography, and hysteroscopy are available to evaluate the size and position of tumors. Ultrasonography should be used initially because it is the least invasive and most cost-effective investigation. Treatment options include hysterectomy, myomectomy, uterine artery embolization, myolysis, and medical therapy. Treatment must be individualized based on such considerations as the presence and severity of symptoms, the patient's desire for definitive treatment, the desire to preserve childbearing capacity, the importance of uterine preservation, infertility related to uterine cavity distortions, and previous pregnancy complications related to fibroid tumors.

  12. Keloids and ultrasound detected fibroids in young African American women.

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    Quaker E Harmon

    Full Text Available OBJECTIVE: Keloids and fibroids share a number of biologic and demographic similarities however there are no published reports of the association between them. The objective of this study was to investigate the association between self-reported keloids and ultrasound detected fibroids in a population of young African American women. STUDY DESIGN: The Study of Environment, Life-style & Fibroids (SELF, is a volunteer cohort of over 1600 African American women aged 23-34 years recruited in Detroit, Michigan. Enrollment occurred between December 2010 and December 2012. Data are available for the first 1196 participants. Participants self-reported a history of raised (hypertrophic scars or scars extending beyond the limits of the original injury (keloid and had an enrollment pelvic ultrasound examination to detect prevalent fibroids. Log linear regression was used to model the association between abnormal scars and prevalent fibroids controlling for possible covariates. Among women with fibroids, associations between particular fibroid characteristics (tumor location, size or number and scarring were assessed using chi-square and Mann Whitney U-tests. RESULTS: Both abnormal scarring (keloids, 9.0%; hypertrophic scars, 28.3% and fibroids (23.3% were common in this cohort. There was no indication [adjusted Risk Ratio (95% Confidence Interval: 0.7 (0.5-1.1] of an association between self-reported keloids and prevalent fibroids. Nor was there any association with hypertrophic scars. Specific characteristics of the prevalent fibroids were not associated with abnormal scarring. CONCLUSION: Despite similarly dysregulated extracellular matrices in keloids and fibroids, these conditions did not tend to co-occur in this young African American population.

  13. Peripheral detection and resolution with mid-/long-wavelength and short-wavelength sensitive cone systems.

    Science.gov (United States)

    Zhu, Hai-Feng; Zele, Andrew J; Suheimat, Marwan; Lambert, Andrew J; Atchison, David A

    2016-08-01

    This study compared neural resolution and detection limits of the human mid-/long-wavelength and short-wavelength cone systems with anatomical estimates of photoreceptor and retinal ganglion cell spacings and sizes. Detection and resolution limits were measured from central fixation out to 35° eccentricity across the horizontal visual field using a modified Lotmar interferometer. The mid-/long-wavelength cone system was studied using a green (550 nm) test stimulus to which S-cones have low sensitivity. To bias resolution and detection to the short-wavelength cone system, a blue (450 nm) test stimulus was presented against a bright yellow background that desensitized the M- and L-cones. Participants were three trichromatic males with normal visual functions. With green stimuli, resolution showed a steep central-peripheral gradient that was similar between participants, whereas the detection gradient was shallower and patterns were different between participants. Detection and resolution with blue stimuli were poorer than for green stimuli. The detection of blue stimuli was superior to resolution across the horizontal visual field and the patterns were different between participants. The mid-/long-wavelength cone system's resolution is limited by midget ganglion cell spacing and its detection is limited by the size of the M- and L-cone photoreceptors, consistent with previous observations. We found that no such simple relationships occur for the short-wavelength cone system between resolution and the bistratified ganglion cell spacing, nor between detection and the S-cone photoreceptor sizes.

  14. Comparison of Sexual Dysfunction Using the Female Sexual Function Index following Surgical Treatments for Uterine Fibroids

    OpenAIRE

    Allison Ryann Louie; Jennifer Alice Armstrong; Laura Katherine Findeiss; Scott Craig Goodwin

    2012-01-01

    Uterine fibroids are a common problem in women. Statistics showing 20–50% of fibroids produce symptoms and consequently patients seek surgical intervention to improve their quality of life. Treatments for fibroids are typically successful in controlling the fibroid disease, yet sexual function following invasive surgical treatments for fibroids can be jeopardized. The Sexual Function Index (FSFI) is a valid instrument producing quantifiable reproducible results. In this paper three case repor...

  15. Percutaneous uterine artery embolization for the treatment of symptomatic fibroids: current status

    Energy Technology Data Exchange (ETDEWEB)

    Lupattelli, Tommaso; Basile, Antonio; Garaci, Francesco Giuseppe; Simonetti, Giovanni

    2005-04-01

    Uterine artery embolization (UAE) is increasingly being used as an alternative treatment to hysterectomy for symptomatic fibroids. Symptoms of pelvic pressure, urinary frequency and menorrhagia are controlled in 73-98% of patients who undergo UAE. At the 1-year follow-up, the uterus may shrink by up to 55% but re-growth of fibroid may however occur. The rate of major complications and amenorrhoea following this procedure is low, ranging in most series from 1 to 3.5% and 1 to 7%, respectively. Nevertheless, the rate of amenorrhoea in women over 45 seems to be higher. In order to completely block the arterial supply to the fibroid, UAE is typically performed in both uterine arteries. Different embolic agents are used such as polyvinyl alcohol, gelfoam and more recently gelatine tris-acryl microspheres. After UAE, perfusion of the uterus is maintained. Uterine function is therefore conserved and although women who become pregnant after UAE seem to be at risk for malpresentation, pre-term birth, cesarean delivery and postpartum hemorrhage, successful pregnancies after UAE have been reported in some series. A major technical problem with UAE remains the possible presence of fibroid blood supply from other sources, such as the ovarian arteries or other pelvic branches, which can lead to failure of the procedure. In conclusion, although randomized trials are still underway, UAE appears a good option for those patients who wish to conserve their fertility or when surgery is contra-indicated. However, to evaluate the long-term effects of UAE longer follow up is required.

  16. Successful Pregnancy after Treatment with Ulipristal Acetate for Uterine Fibroids

    Directory of Open Access Journals (Sweden)

    Javier Monleón

    2014-01-01

    Full Text Available This case report presents a clinical pregnancy after ulipristal acetate (UA to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5 mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometrial cavity were noted by transvaginal ultrasound after treatment. An endometrial biopsy excluded histologic endometrial changes. Three months after the end of UA the patient reported amenorrhea for 5 weeks and a clinical pregnancy was confirmed with transvaginal ultrasound. She underwent a subsequent uneventful pregnancy. Thus, the spontaneous pregnancy after UA to reduce fibroid size may support the potential clinical utility of this selective progesterone receptor modulator in the management of women with pregnancy desire and uterine fibroids after a prior myomectomy. Patients who refuse a new surgical procedure and/or those who are going to undergo assisted reproductive techniques would benefit from UA. It effectively shrinks fibroids, avoids risks of a new surgical procedure, and allows an immediate attempt at conception after the end of treatment.

  17. Successful pregnancy after treatment with ulipristal acetate for uterine fibroids.

    Science.gov (United States)

    Monleón, Javier; Martínez-Varea, Alicia; Galliano, Daniela; Pellicer, Antonio

    2014-01-01

    This case report presents a clinical pregnancy after ulipristal acetate (UA) to decrease uterine fibroid size. A 37-year-old patient, gravida 1, abortus 1, with uterine fibroids was treated with 5 mg of UA daily for 13 weeks starting eight months after a multiple laparotomic myomectomy. Fibroid shrinkage and restoration of the morphology of endometrial cavity were evaluated in order to allow a subsequent pregnancy. A decrease of the uterine fibroids and a normal morphology of the endometrial cavity were noted by transvaginal ultrasound after treatment. An endometrial biopsy excluded histologic endometrial changes. Three months after the end of UA the patient reported amenorrhea for 5 weeks and a clinical pregnancy was confirmed with transvaginal ultrasound. She underwent a subsequent uneventful pregnancy. Thus, the spontaneous pregnancy after UA to reduce fibroid size may support the potential clinical utility of this selective progesterone receptor modulator in the management of women with pregnancy desire and uterine fibroids after a prior myomectomy. Patients who refuse a new surgical procedure and/or those who are going to undergo assisted reproductive techniques would benefit from UA. It effectively shrinks fibroids, avoids risks of a new surgical procedure, and allows an immediate attempt at conception after the end of treatment.

  18. [Prevalence of malnutrition in a mid-long term stay unit].

    Science.gov (United States)

    Argente Pla, María; García Malpartida, Katherine; León De Zayas, Beatriz; Martín Sanchis, Silvia; Micó García, Andrea; Del Olmo García, Maria Isabel; Moral Moral, Pedro; Moreno Muñoz, Iván; Beseler Soto, Rosario; Ramos Prol, Agustín; Merino Torres, Juan Francisco

    2014-10-06

    Introducción: La desnutrición es un problema de salud frecuente, especialmente en el ámbito hospitalario donde se asocia con estancias más prolongadas y mayor tasa de morbi-mortalidad. Por otro lado, los avances científicos actuales y la mayor expectativa de vida, han producido un aumento progresivo de unidades de media y larga estancia (UMLE). Objetivos: Determinar la prevalencia de desnutrición en una UMLE mediante el uso del MNA y la VGS, así como analizar los factores/características clínicas asociadas a la misma y sus repercusiones. Métodos: Estudio transversal, descriptivo de una cohorte formada por 201 pacientes ingresados en la UMLE de un Hospital universitario de forma consecutiva durante 12 meses. Se recogieron variables clínicas, antropométricas, bioquímicas e historia nutricional, así como escala de comorbilidad de Charlson, escala cognitiva de Pfeiffer, escala funcional de Barthel y presencia de edemas, ascitis y úlceras por presión. El estado nutricional fue evaluado en las primeras 24-72 horas de ingreso mediante el MNA y la VGS. La presencia de disfagia se evaluó mediante el cuestionario EAT-10 y el MECV-V. Resultados: La prevalencia global de desnutrición fue del 76,6%, siendo la desnutrición mixta grave la más prevalente (20.4%). Los pacientes desnutridos tenían más edad (p=0,002), mayor grado de dependencia (p.

  19. Induced and Spontaneous Abortion and Risk of Uterine Fibroids.

    Science.gov (United States)

    Song, Lulu; Shen, Lijun; Mandiwa, Chrispin; Yang, Siyi; Liang, Yuan; Yuan, Jing; Wang, Youjie

    2017-01-01

    The relationship between abortion and uterine fibroids has received little attention. The aim of the present study was to explore the association between number of induced and spontaneous abortions and the risk of uterine fibroids in middle-aged and older Chinese women. A total of 14,595 retired female employees from the Dongfeng-Tongji cohort study were included in our analysis. Information on induced and spontaneous abortions was collected by trained interviewers through face-to-face interviews. Diagnosis of uterine fibroids was based on ultrasound or self-reported physician diagnosis of uterine fibroids. Logistic regression models were used to explore the associations between number of induced and spontaneous abortions and the risk of uterine fibroids. The prevalence of uterine fibroids was 15.1% among all participants. Higher number of induced abortions was associated with an increased risk of uterine fibroids (1 induced abortion: odds ratios [ORs] = 1.32, 95% confidence interval [CI] 1.18-1.48; 2 induced abortions: OR = 1.45, 95% CI 1.28-1.64; and ≥3 induced abortions: OR = 1.62, 95% CI 1.39-1.90). Compared with women without induced abortion, ORs for women with 1, 2, and ≥3 were 1.17 (95% CI 1.03-1.32), 1.21 (95% CI 1.06-1.39), and 1.36 (95% CI 1.15-1.61), respectively, after adjustment for potential confounders. No association was observed between the number of spontaneous abortions and the risk of uterine fibroids. The findings of this study showed that induced abortion may be an independent risk factor for uterine fibroids in middle-aged and older Chinese women.

  20. The Influence of Oxytocin on the Blood Perfusion of Uterine Fibroids: Contrast-enhanced Ultrasonography Evaluation

    Directory of Open Access Journals (Sweden)

    Yang Wang

    2016-03-01

    Conclusion: This CEUS study demonstrated that the use of parenteral oxytocin can significantly reduce the blood perfusion of the uterine fibroids, which may help to enhance the therapeutic efficacy for high intensity focused ultrasound ablation of uterine fibroids.

  1. Uterine artery embolization for the treatment of symptomatic fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung Ah; Kim, Man Deuk; Kim, Hee Jin; Lee, Mee Hwa; Cho, Jin Ho; Cha, Sun Hee; Yoon, Sang Wook; Ahn, Eun Hee [Bundang CHA General Hospital Pochon CHA University, Sungnam (Korea, Republic of)

    2005-07-15

    The aim of this study was to determine the potential usefulness of uterine artery embolization (UAE) for the management of uterine leiomyoma. Sixty nine patients (mean age; 40.3 years, age range; 31-52 years) who underwent UAE for symptomatic fibroids (with menorrhagia, dysmenorrhoea and bulk-related symptoms) from January 2000 to December 2000 were retrospectively analyzed. The mean follow-up period was 3.5 months (range: 1-8 months). The fibroids ranged in size from 2.0 cm to 13.2 cm with a mean size of 5.8 cm. We performed embolization using polyvinyl alcohol particles (250-710 {mu} m). The improvement of the clinical symptoms was analyzed. Reduction of the uterine and predominant fibroid volumes was assessed using MRI. Symptom improvement for the menorrhagia (87.5%), dysmenorrhoea (83.3%) and the bulk-related symptoms (79.2%) was reported. Complications includes ovarian failure in four patients (5.8% of the total patients, mean age: 43.3 yrs) and infection in three patients (4.3% of the total patients) who underwent conservative management with intravenous antibiotics and analgesics. The volume reduction rate of the uterus and the predominant fibroids after uterine artery embolization were 36.3% and 56.6%, respectively. UAE is a promising new treatment for symptomatic fibroids and may be a valuable alternative to hysterectomy.

  2. Contemporary management of uterine fibroids: focus on emerging medical treatments.

    Science.gov (United States)

    Singh, Sukhbir Sony; Belland, Liane

    2015-01-01

    This review provides an overview of therapeutic options, with a specific focus on the emerging role of medical options for UF management. PubMed, Google Scholar, and Cochrane Systematic Reviews were searched for articles published between 1980 and 2013. Relevant articles were identified using the following terms: 'uterine fibroids', 'leiomyoma', 'heavy menstrual bleeding', and 'menorrhagia'. The reference lists of articles identified were also searched for other relevant publications. Because of the largely benign nature of UFs, the most conservative options that minimize morbidity/risk and optimize outcomes should be considered. Watchful waiting, or no immediate intervention combined with regular follow-up, is an appropriate option for the majority of UF patients who experience no symptoms. For women with symptomatic UFs, the optimal treatment should restore quality of life through rapid relief of UF signs and symptoms, reduce tumor size for a sustained period, and maintain or improve fertility. Invasive surgical treatments, such as hysterectomy, have historically been the mainstay of UF treatment. Less invasive surgical and interventional techniques, such as myomectomy, uterine artery embolization, endometrial ablation, and myolysis provide alternatives to hysterectomy. Until recently, medical management of UFs was characterized by short-term treatments and therapies that provided symptomatic control. In addition to controlling abnormal uterine bleeding, newer medical therapies, including the recently Health-Canada-approved ulipristal acetate, act directly to shrink the tumor. Although no agent is currently approved for such use, emerging evidence suggests the potential for long-term medical management of UFs. The advent of novel medical therapies may diminish the long-held reliance on more invasive surgical UF treatment options.

  3. Unplanned pregnancy after ultrasound-guided percutaneous microwave ablation of uterine fibroids: A follow-up study.

    Science.gov (United States)

    Bing-song, Zhang; Jing, Zhang; Zhi-Yu, Han; Chang-tao, Xu; Rui-fang, Xu; Xiu-mei, Li; Hui, Liu

    2016-01-06

    A follow-up study was performed with 169 women of childbearing age who underwent ultrasound-guided percutaneous microwave ablation (UPMWA) therapy for symptomatic uterine fibroids in the Chinese PLA General Hospital from June 2007 to December 2014. This study aimed to observe the incidence of unplanned pregnancies in these women after UPMWA treatment in order to evaluate its effect on natural conception. Ten unplanned pregnancies in nine women were occurred. Of the nine patients, six did not want the pregnancy and chose for induced abortion to end the pregnancy at an early stage. Three chose to continue with the pregnancy and gave birth to a healthy term infant delivered by cesarean section (of these three patients, two had been previously diagnosed as infertility). None of the patients had any serious obstetric complications. After UPMWA treatment for uterine fibroids, patients may conceive naturally, the impact of the procedure on fertility and pregnancy outcomes is worthy of further prospective study in larger sample.

  4. Assessing the Reliability and Quality of Online Uterine Fibroid Embolization Resources

    Energy Technology Data Exchange (ETDEWEB)

    Kaicker, Jatin; Wu Ke; Athreya, Sriharsha, E-mail: sathreya@stjoes.ca [Michael G. Degroote School of Medicine, Department of Medical Imaging (Canada)

    2013-04-15

    This study was designed to examine the best internet resources about uterine fibroid embolization (UFE) pertinent to medical trainees, radiologists, gynecologists, family physicians, and patients. The terms 'uterine fibroid embolization,' 'uterine fibroid embolization,' and 'uterine artery embolization' were entered into Google, Yahoo, and Bing search engines; the top 20 hits were assessed. The hits were categorized as organizational or nonorganizational. Additionally, 23 radiological and obstetrical organizations were assessed. The DISCERN instrument and Journal of the American Medical Association (JAMA) benchmarks (authorship, attribution, currency, disclosure) were used to assess the information critically. The scope, strength, weaknesses, and unique features were highlighted for the top five organizational and nonorganizational websites. A total of 203 websites were reviewed; 23 were removed in accordance with the exclusion criteria and 146 were duplicate websites, for a total of 34 unique sites. It was found that 35 % (12/34 websites) were organizational (family medicine, radiology, obstetrics/gynecology) and 65 % (22/34 websites) were nonorganizational (teaching or patient resources). The overall mean DISCERN score was 49.6 (10.7). Two-tailed, unpaired t test demonstrated no statistically significant difference between organizational and nonorganizational websites (p = 0.101). JAMA benchmarks revealed 44 % (15/34 websites) with authorship, 71 % (24/34 websites) with attribution, 68 % (23/34 websites) with disclosure, and 47 % (16/34 websites) with currency. The overall quality of websites for UFE is moderate, with important but not serious shortcomings. The best websites provided relevant information about the procedure, benefits/risks, and were interactive. DISCERN scores were compromised by sites failing to provide resources for shared decision-making, additional support, and discussing consequence of no treatment. JAMA

  5. Uteroenteric Fistula Resulting From Fibroid Expulsion After Uterine Fibroid Embolization: Case Report and Review of the Literature

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez, Luis B., E-mail: lbgutier@stanford.edu [Stanford University, School of Medicine (United States); Bansal, Anshuman K., E-mail: abansal@mednet.ucla.edu [University of California at Los Angeles, Department of Radiology (United States); Hovsepian, David M., E-mail: hovsepian@stanford.edu [Stanford University, School of Medicine (United States)

    2012-10-15

    A 44-year-old woman underwent uncomplicated uterine fibroid embolization (UFE) for menstrual and bulk-related symptoms in an enlarged, myomatous uterus. After surgery, she spontaneously sloughed a large mass of fibroids that arrested in the cervical canal during passage. Four days after gynecological extraction, she developed copious vaginal discharge that contained enteric contents. Contrast-enhanced computed tomography (CT) demonstrated a fistula between the small bowel and the uterus. She subsequently underwent hysterectomy, left oophorectomy, and small-bowel resection. Her postoperative recovery was uneventful.

  6. Ayurvedic management of recurrent abortions due to uterine fibroid

    Directory of Open Access Journals (Sweden)

    Shailendra Dadarao Katakdound

    2017-01-01

    Full Text Available Uterine fibroids are present in 30-70% of women of reproductive age. Uterine fibroids distort the uterine cavity. Therefore there is consensus of a negative impact on both the clinical pregnancy and delivery rates.[2] In addition, studies have also reported an increased risk of spontaneous miscarriage with submucosal fibroids. In biomedicine, myomectomy is considered the treatment of choice and Assisted Reproductive Technology is advised to overcome infertility. In Hārita Saṃhitā treatment is given for recurrent abortion (Garbhasrāvī. In this study, considering pitta doṣa and altered uterine receptivity (kṣetra duṣṭi as causative factors, purgation (virecana karma was done, enema (yoga basti was given after post purgation protocol (saṃsarjana karma. After body purification (śodhana, garbhasthāpaka drugs were given to the patient for one month. Patient conceived in the second month with this treatment. In Antenatal Care, haematinics and calcium supplements and month wise Ayurvedic medication (Māsānumāsika kaṣāya were given for nine months. Elective caesarean section as done after GA 38 weeks (USG followed by inj. Wymesone 8 mg. The procedure uneventful. Thus proving Ayurvedic management of recurrent abortion due to uterine fibroid. It is cost effective and improves and normalises uterine receptive environment.

  7. Alterations in uterine hemodynamics caused by uterine fibroids and their impact on in vitro fertilization outcomes.

    Science.gov (United States)

    Moon, Jei-Won; Kim, Chung-Hoon; Kim, Jun-Bum; Kim, Sung-Hoon; Chae, Hee-Dong; Kang, Byung-Moon

    2015-12-01

    To investigate the impact of fibroids on the blood flow of the uterine and subendometrial arteries and in vitro fertilization (IVF) outcomes. In this study, we analyzed 86 IVF/intracytoplasmic sperm injection (ICSI) cycles in which a gonadotropin-releasing hormone antagonist protocol was used for controlled ovarian stimulation between January 2008 and March 2009. The subjects comprised 86 infertile women with (fibroid group, n=43) or without (control group, n=43) uterine fibroids. Patient characteristics were similar between the fibroid and control groups. The IVF/ICSI outcomes in patients with fibroids were similar to those of patients in the control group. The resistance index (RI) and pulsatile index (PI) of the uterine and subendometrial arteries on the day of embryo transfer were also comparable between the two groups. IVF outcomes and uterine hemodynamics in patients with multiple (≥2) fibroids were similar to those of patients with a single fibroid. However, clinical pregnancy and implantation rates were significantly lower in patients with fibroids who experienced uterine cavity distortion than in patients with fibroids who had a normal uterine cavity (both p<0.05). The RI and PI of the subendometrial artery were significantly higher on the day of embryo transfer in patients with fibroids who experienced uterine cavity distortion than in patients with fibroids who had a normal uterine cavity (both p<0.05). Fibroids which distorting the uterine cavity might impair the subendometrial artery blood flow clinical pregnancy rate and embryo implantation rate in infertile patients undergoing IVF. Otherwise, IVF outcomes were not influenced by the presence of uterine fibroids.

  8. Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: promising options for prevention and treatment of uterine fibroids?

    Science.gov (United States)

    Islam, Md Soriful; Akhtar, Most Mauluda; Ciavattini, Andrea; Giannubilo, Stefano Raffaele; Protic, Olga; Janjusevic, Milijana; Procopio, Antonio Domenico; Segars, James H; Castellucci, Mario; Ciarmela, Pasquapina

    2014-08-01

    Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70-80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 6 billion dollars annually in the United States. Unfortunately, no long-term medical treatments are available. Dysregulation of inflammatory processes are thought to be involved in the initiation of leiomyoma and extracellular matrix deposition, cell proliferation, and angiogenesis are the key cellular events implicated in leiomyoma growth. In modern pharmaceutical industries, dietary phytochemicals are used as source of new potential drugs for many kinds of tumors. Dietary phytochemicals may exert therapeutic effects by interfering with key cellular events of the tumorigenesis process. At present, a negligible number of phytochemicals have been tested as therapeutic agents against fibroids. In this context, our aim was to introduce some of the potential dietary phytochemicals that have shown anti-inflammatory, antiproliferative, antifibrotic, and antiangiogenic activities in different biological systems. This review could be useful to stimulate the evaluation of these phytochemicals as possible therapies for uterine fibroids.

  9. Incarceration of a sessile uterine fibroid in an umbilical hernia during pregnancy.

    Science.gov (United States)

    Seims, A D; Lube, M W

    2009-06-01

    On rare occasions, uterine fibroids complicate pregnancy. More commonly, fibroids exert a mass effect that either prevents implantation of an egg or becomes problematic as a fetus grows. Less frequently, pregnancies are affected by fibroid herniation through a fascial defect. Several publications describing herniation of pedunculated fibroids exist, two of which were in umbilical hernia sacs. There is, to our knowledge, only one publication describing the presence of a sessile uterine fibroid in an umbilical hernia. This case report adds to the literature by describing a 34-year-old primigravid woman with an umbilical hernia that contained a sessile uterine fibroid and provides parameters that can be used in the initial evaluation of a pregnant woman with an abdominal wall hernia.

  10. Comparison of Sexual Dysfunction Using the Female Sexual Function Index following Surgical Treatments for Uterine Fibroids

    Directory of Open Access Journals (Sweden)

    Allison Ryann Louie

    2012-01-01

    Full Text Available Uterine fibroids are a common problem in women. Statistics showing 20–50% of fibroids produce symptoms and consequently patients seek surgical intervention to improve their quality of life. Treatments for fibroids are typically successful in controlling the fibroid disease, yet sexual function following invasive surgical treatments for fibroids can be jeopardized. The Sexual Function Index (FSFI is a valid instrument producing quantifiable reproducible results. In this paper three case reports are evaluated by the FSFI and compared between the following treatment groups: hysterectomy, myomectomy, and uterine embolization. Our goal is to illustrate how each of these treatment outcomes can result in sexual dysfunction and therefore decreased quality of life. Effects of invasive fibroid treatments on sexual functioning would be helpful in guiding patient’s ultimate decisions regarding treatment.

  11. Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility.

    Science.gov (United States)

    Styer, Aaron K; Jin, Susan; Liu, Dan; Wang, Baisong; Polotsky, Alex J; Christianson, Mindy S; Vitek, Wendy; Engmann, Lawrence; Hansen, Karl; Wild, Robert; Legro, Richard S; Coutifaris, Christos; Alvero, Ruben; Robinson, Randal D; Casson, Peter; Christman, Gregory M; Christy, Alicia; Diamond, Michael P; Eisenberg, Esther; Zhang, Heping; Santoro, Nanette

    2017-03-01

    To investigate the association of non-cavity-distorting uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination (OS-IUI) in couples with unexplained infertility. Secondary analysis from a prospective, randomized, multicenter clinical trial investigating fertility outcomes after OS-IUI. Reproductive Medicine Network clinical sites. Nine hundred couples with unexplained infertility who participated in the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial. Participants were randomized to one of three arms (clomiphene citrate, letrozole, or gonadotropins), and treatment was continued for up to four cycles or until pregnancy was achieved. Conception (serum hCG increase), clinical pregnancy (fetal cardiac activity), and live birth rates. A total of 102/900 participants (11.3%) had at least one documented fibroid and a normal uterine cavity. Women with fibroids were older, more likely to be African American, had a greater uterine volume, lower serum antimüllerian hormone levels, and fewer antral follicles than women without fibroids. In conception cycles, clinical pregnancy rates were significantly lower in participants with fibroids than in those without uterine fibroids. Pregnancy loss before 12 weeks was more likely in African American women with fibroids compared with non-African American women with fibroids. There was no difference in conception and live birth rates in subjects with and without fibroids. No differences were observed in conception and live birth rates in women with non-cavity-distorting fibroids and those without fibroids. These findings provide reassurance that pregnancy success is not impacted in couples with non-cavity-distorting fibroids undergoing OS-IUI for unexplained infertility. NCT01044862. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  12. Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women.

    Science.gov (United States)

    Nagata, Chisato; Nakamura, Kozue; Oba, Shino; Hayashi, Makoto; Takeda, Noriyuki; Yasuda, Keigo

    2009-05-01

    Certain dietary components which could affect oestrogen may have implications in the aetiology of uterine fibroids. We previously found that soya intake was inversely associated with a subsequent risk of hysterectomy, suggesting a potentially protective effect of soya against uterine fibroids, the major clinical indication for hysterectomy. We cross-sectionally assessed the associations of intakes of fat, soya foods, dietary fibre and alcohol with uterine fibroids. Study subjects were 285 premenopausal Japanese women participating in a health-check up programme, including gynaecological examinations, provided by a general hospital between October 2003 and March 2006. The presence of fibroids was confirmed by transvaginal sonogram. If women had undergone hysterectomy, self-report of fibroids was accepted. Each subject's usual diet, including alcohol, was determined with the use of a validated FFQ. Fifty-four women were identified as prevalent cases of fibroids or having had hysterectomy due to fibroids. The mean alcohol intake was statistically significantly higher among women with fibroids than among those without fibroids after controlling for known or suspected risk factors. For the highest compared with the lowest tertile of alcohol intake, the OR of uterine fibroids was 2.78 (95% CI 1.25, 6.20). There was no significant association of intake of fats, soya isoflavones or dietary fibre with uterine fibroids. The data suggest that higher alcohol intake is associated with a higher prevalence of uterine fibroids. Further studies on diet, especially phyto-oestrogens, and uterine fibroids are needed given the limited data currently available.

  13. [Epidemiological data for uterine fibroids in France in 2010-2012 in medical center--analysis from the French DRG-based information system (PMSI)].

    Science.gov (United States)

    Fernandez, H; Chabbert-Buffet, N; Koskas, M; Nazac, A

    2014-10-01

    Uterine fibroids are a common disorder, responsible for menorrhagia/metrorrhagia and pelvic pain and remain the leading reason for hysterectomy in France. Although it is common disorder, French epidemiological data are locking. The objective of this study was to realize an epidemiological analysis from the medicalized information system program (PMSI). The diagnosis codes were selected from 10th version of the International Classification Disease. The medical procedures concerning uterine fibroids were selected (so called: procedures listed). A descriptive analysis was performed from hospitals stays, patients' characteristics and medical procedures (mean, standard distribution, median, range, quartile). In 2012, 46,126 patients (median age: 46 years old) were admitted in hospital (public or private hospitals) due to uterine fibroid corresponding to 47,690 hospital stays (hospital stays for surgery: 32,397). Diagnosis of anemia was reported in approximately 8% of patients and 7.1% of patients hospitalized in 2012 had already been hospitalized between 2004-2012. The median length of hospital stay was 4 days. In 2012, 16,070 hospital stays were reported for total or subtotal hysterectomy, 16,384 hospitals stays for myomectomy and 1376 hospital stays for embolization. In terms of management care, among 46,126 patients with uterine fibroids (principal or related diagnosis), 31,846 patients received a procedure listed in a surgical diagnostic related groups (DRG). To conclude, the study permits to update the epidemiological data concerning uterine fibroid management between 2010-2011-2012 in final. Because the PMSI collects partially information regarding epidemiological data, a clear epidemiological study is needed either with database from health insurance or with dedicated study. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  14. Postoperative Quality of Life and Sexual Function in Premenopausal Women Undergoing Laparoscopic Myomectomy for Symptomatic Fibroids: A Prospective Observational Cohort Study

    Science.gov (United States)

    Radosa, Julia Caroline; Radosa, Christoph Georg; Mavrova, Russalina; Wagenpfeil, Stefan; Hamza, Amr; Joukhadar, Ralf; Baum, Sascha; Karsten, Maria; Juhasz-Boess, Ingolf; Solomayer, Erich-Franz; Radosa, Marc Philipp

    2016-01-01

    Introduction Uterine leiomyomas are the most common benign gynecologic tumors. To date laparoscopy myomectomy is the gold standard for treatment of symptomatic fibroids in reproductive-aged women. Detailed counseling about the effects of this procedure on postoperative sexuality and quality of life is important in these patients. However, available data on these subjects are limited and contradictory. The aim of this study was to assess sexual function and quality of life in premenopausal women undergoing laparoscopic myomectomy for symptomatic uterine fibroids. Material and Methods All premenopausal women who underwent laparoscopic myomectomy for symptomatic fibroids between April 2012 and August 2014 at a tertiary university center were enrolled in this prospective observational cohort study. Sexual function and quality of life were assessed for the pre- and postoperative (six months post-operatively) state using two validated questionnaires, the Female Sexual Function Index (FSFI) and the European Quality of Life Five-Dimension Scale (EQ-5D). Results Ninety-five of the 115 (83%) eligible patients completed the study. Overall a significant improvement in quality of life and sexual function was observed in the study cohort: Median FSFI (28 (18.7–35.2)) and EQ-5D scores (1 (0.61–1) after laparoscopic myomectomy were significantly higher than preoperative scores (21.2 (5.2–33.5); 0.9 (0.2–1); p ≤ 0.01). The number, position and localization of the largest fibroids were not correlated with pre- or postoperative sexual function or quality of life. Conclusion Laparoscopic myomectomy might have positive short-term effects on postoperative quality of life and sexual function in premenopausal women suffering from symptomatic fibroids. PMID:27898669

  15. Embolización arterial de miomas uterinos: resultados morfológicos y funcionales a corto y mediano plazo Uterine fibroid embolization: morphologic and functional results at short-to-medium term

    Directory of Open Access Journals (Sweden)

    Sergio Lucino

    2010-06-01

    (UAE is an alternative to conventional surgical therapy. Purpose: The objective of this study was to evaluate the usefulness of UAE as treatment for symptomatic myomatosis at short and intermediate term, to evaluate the safety of this technique and to compare its results with other alternative treatments. Material and methods: Prospective study of 28 selected patients who underwent UAE from December 2000 to April 2005 and followed up until April 2008 whose average age was 41 years. All the patients presented with symptomatic myomatosis with menstrual bleeding disorders. All the patients desired to keep their uterus. The embolizing material was polyvinyl alcohol particles of 500-1000 μm. Results: Twenty seven patients were discharged 24 hours after the UAE. One patient remained hospitalized 12 more hours and 1 was readmitted 48 hours after the procedure, both due to pelvic pain. All the patients returned to their usual activities 7 + days after the UAE. None of the patients presented complications. All the patients remained satisfied with the results of the procedure at the 6-month control. Conclusion: UAE is an outstanding alternative to conventional treatment, with high technical success and safety. It should be considered for patients with symptomatic uterine myomas.

  16. Uterine Fibroids: Pathogenesis and Interactions with Endometrium and Endomyometrial Junction

    Directory of Open Access Journals (Sweden)

    Andrea Ciavattini

    2013-01-01

    Full Text Available Uterine leiomyomas (fibroids or myomas are benign tumors of uterus and clinically apparent in a large part of reproductive aged women. Clinically, they present with a variety of symptoms: excessive menstrual bleeding, dysmenorrhoea and intermenstrual bleeding, chronic pelvic pain, and pressure symptoms such as a sensation of bloatedness, increased urinary frequency, and bowel disturbance. In addition, they may compromise reproductive functions, possibly contributing to subfertility, early pregnancy loss, and later pregnancy complications. Despite the prevalence of this condition, myoma research is underfunded compared to other nonmalignant diseases. To date, several pathogenetic factors such as genetics, microRNA, steroids, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in the development and growth of leiomyoma. This paper summarizes the available literature regarding the ultimate relative knowledge on pathogenesis of uterine fibroids and their interactions with endometrium and subendometrial myometrium.

  17. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

    DEFF Research Database (Denmark)

    Vanharanta, S; Pollard, PJ; Lehtonen, HJ

    2006-01-01

    Defects in mitochondrial enzymes predispose to severe developmental defects as well as tumorigenesis. Heterozygous germline mutations in the nuclear gene encoding fumarate hydratase (FH), an enzyme catalyzing the hydration of fumarate in the Krebs tricarboxylic acid cycle, cause hereditary...... leiomyomatosis and renal cell cancer; yet the connection between disruption of mitochondrial metabolic pathways and neoplasia remains to be discovered. We have used an expression microarray approach for studying differences in global gene expression pattern caused by mutations in FH. Seven uterine fibroids...... carrying FH mutations were compared with 15 fibroids with wild-type FH. The two groups showed markedly different expression profiles, and multiple differentially expressed genes were detected. The most significant increase in FH mutants was seen in the expression of carbohydrate metabolism- and glycolysis...

  18. Ultrasonographic Evaluation of the Change in Uterine Fibroids Induced by Treatment with a Gnrh Analog

    Directory of Open Access Journals (Sweden)

    Chun-Chieh Chia

    2006-06-01

    Conclusion: We found that the volumes of the uterus and fibroids decreased significantly after treatment with two consecutive doses (given a month apart of GnRHa. The 3D color Doppler including a histogram and blood flow parameters is another useful tool for fibroid evaluation.

  19. Parasitic fibroid: case report and novel approach in reducing incidence of future cases

    Directory of Open Access Journals (Sweden)

    Sukainah S.

    2016-08-01

    Full Text Available We report a case of parasitic fibroid which developed less than 1 year following laparoscopic myomectomy using power morcellation. Following this case, a novel approach in reducing the incidence of future parasitic fibroid is described. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2836-2839

  20. Hypovitaminosis D and "small burden" uterine fibroids: Opportunity for a vitamin D supplementation.

    Science.gov (United States)

    Ciavattini, Andrea; Delli Carpini, Giovanni; Serri, Matteo; Vignini, Arianna; Sabbatinelli, Jacopo; Tozzi, Alessandra; Aggiusti, Alice; Clemente, Nicolò

    2016-12-01

    The aim of this study was to evaluate the effect of vitamin D supplementation in women with hypovitaminosis D and "small burden" uterine fibroids.This study focused on 208 women diagnosed with uterine fibroids and concomitant hypovitaminosis D, from January to December 2014. One hundred eight women of the initial study population were diagnosed with "small burden" uterine fibroids. Among them, those who underwent a proper vitamin D supplementation constituted the "study group" (n = 53), while women who spontaneously refused the therapy or did not perform it properly, constituted the "control group" (n = 55). The characteristics of uterine fibroids, the fibroid-related symptoms, and the vitamin D serum levels were evaluated 12 months after the initial diagnosis.In women with uterine fibroids, a negative correlation emerged between the baseline 25-hydroxy-cholecalciferol (25-OH-D3) concentration and both the volume of the largest fibroid (r = -0.18, P = 0.01) and the total volume of fibroids (r = -0.19, P = 0.01). No correlation was found between the baseline 25-OH-D3 levels and the number of fibroids per patient (r = -0.10, P = 0.16). In women of the "study group," a significant increase in the 25-OH-D3 serum level was observed after 12 months of supplementation, and a lower rate of surgical or medical treatment due to the "progression to extensive disease" was reported (13.2% vs 30.9%, P = 0.05).Supplementation therapy with 25-OH-D3 restores normal vitamin D serum levels in women with "small burden" fibroids. In these women, vitamin D supplementation seems to reduce the progression to an extensive disease, and thus the need of conventional surgical or medical therapy.

  1. Clinical utility of ulipristal acetate for the treatment of uterine fibroids: current evidence

    Directory of Open Access Journals (Sweden)

    Trefoux Bourdet A

    2015-03-01

    Full Text Available Alice Trefoux Bourdet, Dominique Luton, Martin Koskas Department of Obstetrics and Gynecology, Bichat University Hospital, Paris Diderot University, Paris, France Abstract: Uterine myoma is the most common benign uterine tumor in women of reproductive age and occurs in 20%–25% of the worldwide population. No currently approved medical treatment is able to completely eliminate fibroids. Surgery, particularly hysterectomy, predominates as the treatment strategy of choice, even though it is associated with risks and complications and causes infertility. Until recently, gonadotropin-releasing hormone agonists were the only available drugs for the preoperative treatment of fibroids. However, ulipristal acetate (UPA, an oral selective progesterone receptor modulator, was recently licensed in Europe for the same indication. Recent studies have demonstrated the efficacy and safety of UPA in the medical management of fibroids before surgery, with a better tolerability profile than leuprolide acetate. Analyzing the literature, we identified new management strategies involving UPA and surgery, considering advantages of both medical and surgical therapy. The advent of UPA will undoubtedly modify the surgical approach to fibroids, but the heterogeneity of these possible indications now requires various original clinical studies to identify the optimal indications for UPA in patients with symptomatic fibroid(s. Keywords: uterine fibroids, medical treatment, selective progesterone receptor modulator, ulipristal acetate, surgery

  2. Vegetarian diet and reduced uterine fibroids risk: A case-control study in Nanjing, China.

    Science.gov (United States)

    Shen, Yang; Wu, Yanting; Lu, Qing; Ren, Mulan

    2016-01-01

    The aim of this study was to investigate whether a vegetarian diet correlates with a potential reduced risk of uterine fibroids. We used data from a case-control study conducted in Southeast University Zhongda Hospital between February 2010 and December 2014. Cases included 600 Chinese Han women with uterine fibroids (case group) whose clinical diagnosis dated back no more than 1 year. Controls were 600 patients without uterine fibroids as well as healthy volunteers (control group). All of the information gathered through the questionnaire survey was analyzed for the risk factors of the uterine fibroids pathogenesis. The multifactor analysis showed that women with uterine fibroids reported a less frequent consumption of broccoli (odds ratio [OR]: 0.552; 95% confidence interval [CI]: 0.316-0.964), cabbage (OR: 0.446; 95%CI: 0.211-0.943), Chinese cabbage (OR: 0.311; 95%CI: 0.102-0.946), tomato (OR: 0.453; 95%CI: 0.241-0.853), and apple (OR: 0.416; 95%CI: 0.213-0.814) (P < 0.05). The original evidence from this epidemiological investigation shows that a high consumption of broccoli, cabbage, Chinese cabbage, tomato and apple seems to be a protective factor for uterine fibroids. We suggest that greater intake of fresh fruits and cruciferous vegetables may be able to reduce the incidence of uterine fibroids. © 2015 Japan Society of Obstetrics and Gynecology.

  3. Mechanistic Study of the Inhibitory Effect of Kaempferol on Uterine Fibroids In Vitro

    OpenAIRE

    Li, Yanxia; Ding, Zhaoxia; Wu, Chuanzhong

    2016-01-01

    Background This study examined the effect of kaempferol on uterine fibroids in vitro and the underlying mechanism, and investigated the potential of kaempferol as a clinical drug for the treatment of uterine fibroids. Material/Methods Uterine fibroid tissue and surrounding smooth muscle tissue were collected for primary culture. Different concentrations of kaempferol (12 μM, 24 μM, and 48 μM) were used to treat the cells for 24, 48, and 72 hours. Ethanol was used in the control group. A CCK-8...

  4. Central cervical fibroid mimicking as chronic uterine inversion: a case report

    Directory of Open Access Journals (Sweden)

    Swati Singh

    2013-08-01

    Full Text Available Leiomyomas are most common benign gynaecological tumor. Most of the fibroids are situated in the body of the uterus, but only in 1-2% cases, they are confined to cervix. We report a case of 33 years old women, para 2 live 2 diagnosed as myomatous polyp on ultrasound and clinically as chronic inversion of uterus. On surgery, we found it as central cervical fibroid with uterus sitting on the fibroid i.e. lantern on the St. Paul’s. [Int J Reprod Contracept Obstet Gynecol 2013; 2(4.000: 687-688

  5. Targeted Vessel Ablation for More Efficient Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Voogt, Marianne J., E-mail: m.voogt@umcutrecht.nl [University Medical Center Utrecht, Department of Radiology (Netherlands); Stralen, Marijn van [University Medical Center Utrecht, Image Sciences Institute (Netherlands); Ikink, Marlijne E. [University Medical Center Utrecht, Department of Radiology (Netherlands); Deckers, Roel; Vincken, Koen L.; Bartels, Lambertus W. [University Medical Center Utrecht, Image Sciences Institute (Netherlands); Mali, Willem P. Th. M.; Bosch, Maurice A. A. J. van den [University Medical Center Utrecht, Department of Radiology (Netherlands)

    2012-10-15

    Purpose: To report the first clinical experience with targeted vessel ablation during magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) treatment of symptomatic uterine fibroids. Methods: Pretreatment T1-weighted contrast-enhanced magnetic resonance angiography was used to create a detailed map of the uterine arteries and feeding branches to the fibroids. A three-dimensional overlay of the magnetic resonance angiography images was registered on 3D T2-weighted pretreatment imaging data. Treatment was focused primarily on locations where supplying vessels entered the fibroid. Patients were followed 6 months after treatment with a questionnaire to assess symptoms and quality of life (Uterine Fibroid Symptom and Quality of Life) and magnetic resonance imaging to quantify shrinkage of fibroid volumes. Results: In two patients, three fibroids were treated with targeted vessel ablation during MR-HIFU. The treatments resulted in almost total fibroid devascularization with nonperfused volume to total fibroid volume ratios of 84, 68, and 86%, respectively, of treated fibroids. The predicted ablated volumes during MR-HIFU in patients 1 and 2 were 45, 40, and 82 ml, respectively, while the nonperfused volumes determined immediately after treatment were 195, 92, and 190 ml respectively, which is 4.3 (patient 1) and 2.3 (patient 2) times higher than expected based on the thermal dose distribution. Fibroid-related symptoms reduced after treatment, and quality of life improved. Fibroid volume reduction ranged 31-59% at 6 months after treatment. Conclusion: Targeted vessel ablation during MR-HIFU allowed nearly complete fibroid ablation in both patients. This technique may enhance the use of MR-HIFU for fibroid treatment in clinical practice.

  6. Giant ileal inflammatory fibroid polyp: a rare cause of intestinal intussusception

    Directory of Open Access Journals (Sweden)

    Daniel Cury Ogata

    2012-09-01

    Full Text Available Ileal inflammatory fibroid polyp is a rare non-neoplastic lesion of the gastrointestinal tract. Intussusception caused by an inflammatory fibroid polyps is uncommon. The authors report a case of a 75 year-old female patient presenting with ileal obstruction due to intussusception of a polypoid lesion. The patient underwent surgical treatment and histopathology confirmed the diagnosis.Os pólipos fibroides inflamatórios são raras lesões não neoplásicas do trato gastrointestinal e a intussuscepção devido a essa entidade é incomum. Os autores relatam um caso de paciente do sexo feminino, 75 anos, que apresentou obstrução ileal devido a uma intussuscepção por lesão polipoide. A paciente foi submetida a tratamento cirúrgico, sendo diagnosticado pólipo fibroide inflamatório do íleo.

  7. Ileo-uterine fistula in a degenerated posterior wall fibroid after Caesarean section.

    Science.gov (United States)

    Shehata, Ayman; Hussein, Naglaa; El Halwagy, Ahmed; El Gergawy, Adel; Khairallah, Mohamed

    2016-03-01

    Uterine fibroids are benign tumors of the myometrium with a diverse range of manifestations. Fibroids can dramatically increase in size during pregnancy due to the increase in estrogen levels. After delivery, the fibroids usually shrink back to their pre-pregnancy size. Uterine myomas may have many complications, including abnormal uterine bleeding, infertility, pressure on nearby organs, degeneration, and malignant transformation. No previous reports have indicated that a fistula may develop between a uterine fibroid and the bowel loops, although previous studies have documented the occurrence of fistulas from the uterus to the bowel following myomectomy or uterine artery embolization performed to treat a myoma. In our case report, we document the rare complication of a fistula occurring between a degenerated myoma in the posterior wall and the ileum 1 week postoperatively in a patient who underwent a Caesarean section but did not have a history of uterine artery embolization.

  8. Alterations in uterine hemodynamics caused by uterine fibroids and their impact on in vitro fertilization outcomes

    OpenAIRE

    Moon, Jei-Won; Kim, Chung-Hoon; Kim, Jun-Bum; Kim, Sung-Hoon; Chae, Hee-Dong; Kang, Byung-Moon

    2015-01-01

    Objective To investigate the impact of fibroids on the blood flow of the uterine and subendometrial arteries and in vitro fertilization (IVF) outcomes. Methods In this study, we analyzed 86 IVF/intracytoplasmic sperm injection (ICSI) cycles in which a gonadotropin-releasing hormone antagonist protocol was used for controlled ovarian stimulation between January 2008 and March 2009. The subjects comprised 86 infertile women with (fibroid group, n=43) or without (control group, n=43) uterine fib...

  9. Ulipristal acetate: a novel pharmacological approach for the treatment of uterine fibroids

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    Biglia N

    2014-02-01

    Full Text Available Nicoletta Biglia,1 Silvestro Carinelli,2 Antonio Maiorana,3 Marta D'Alonzo,1 Giuseppe Lo Monte,4 Roberto Marci4 1Department of Obstetrics and Gynaecology, Mauriziano "Umberto I" Hospital, University of Turin, Turin, 2Department of Pathology, European Institute of Oncology, Milan, 3Department of Obstetrics and Gynecology, ARNAS Civico Hospital, Palermo, 4Department of Morphology, Surgery and Experimental Medicine, Section of Obstetrics and Gynecology, Infertility Unit, University of Ferrara, Ferrara, Italy Abstract: Uterine fibroids are the most common benign tumors of the female genital tract. The management of symptomatic fibroids has traditionally been surgical; however, alternative pharmacological approaches have been proposed to control symptoms. To date, gonadotropin-releasing hormone analogs are the only available drugs for the preoperative treatment of fibroids. However, the US Food and Drug Administration recently authorized ulipristal acetate (UPA, an oral selective progesterone-receptor modulator, for the same indication. UPA is a new, effective, and well-tolerated option for the preoperative treatment of moderate and severe symptoms of uterine fibroids in women of reproductive age. According to clinical data, UPA shows several advantages: it is faster than leuprolide in reducing the fibroid-associated bleeding, it significantly improves hemoglobin and hematocrit levels in anemic patients, and it grants a significant reduction in the size of fibroids, which lasts for at least 6 months after the end of the treatment. Furthermore, UPA displays a better tolerability profile when compared to leuprolide; in fact, it keeps estradiol levels at mid follicular phase range, thereby reducing the incidence of hot flushes and exerting no impact on bone turnover. On the grounds of this evidence, the administration of 5 mg/day ulipristal acetate for 3 months is suggested for different patient categories and allows for planning a treatment strategy

  10. Application of a Patient Derived Xenograft Model for Predicative Study of Uterine Fibroid Disease.

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    Martin Fritsch

    Full Text Available Human uterine fibroids, benign tumors derived from the smooth muscle layers of the uterus, impose a major health burden to up to 50% of premenopausal women in their daily life. To improve our understanding of this disease, we developed and characterized a patient-derived xenograft model by subcutaneous transplantation of pieces of human uterine fibroid tissue into three different strains of severe combined immunodeficient mice. Engrafted uterine fibroid tissue preserved the classical morphology with interwoven bundles of smooth muscle cells and an abundant deposition of collagenous matrix, similar to uterine fibroids in situ. The grafts expressed both estrogen receptor 1 and progesterone receptor. Additionally, both receptors were up-regulated by estrogen treatment. Growth of the fibroid grafts was dependent on 17β-estradiol and progesterone supplementation at levels similar to women with the disease and was studied for up to 60 days at maximum. Co-treatment with the antiprogestin mifepristone reduced graft growth (four independent donors, p<0.0001 two-sided t-test, as did treatment with the mTOR inhibitor rapamycin (three independent donors, p<0.0001 two-sided t-test. This in vivo animal model preserves the main histological and functional characteristics of human uterine fibroids, is amenable to intervention by pharmacological treatment, and can thus serve as an adequate model for the development of novel therapies.

  11. Mechanistic Study of the Inhibitory Effect of Kaempferol on Uterine Fibroids In Vitro.

    Science.gov (United States)

    Li, Yanxia; Ding, Zhaoxia; Wu, Chuanzhong

    2016-12-08

    BACKGROUND This study examined the effect of kaempferol on uterine fibroids in vitro and the underlying mechanism, and investigated the potential of kaempferol as a clinical drug for the treatment of uterine fibroids. MATERIAL AND METHODS Uterine fibroid tissue and surrounding smooth muscle tissue were collected for primary culture. Different concentrations of kaempferol (12 μM, 24 μM, and 48 μM) were used to treat the cells for 24, 48, and 72 hours. Ethanol was used in the control group. A CCK-8 colorimetric assay was used to detect cell proliferation. Real-time PCR and immunoblot were used to detect estrogen receptor (ER), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF) levels in mRNA and protein. RESULTS The differences in proliferation at different time points and concentrations of kaempferol were statistically significant. The inhibitory effect of kaempferol on mRNA levels of ER and IGF, and protein levels of ER, VEGF, and IGF-1 were positively correlated with kaempferol concentration. Changes in kaempferol concentration showed no effect on VEGF mRNA expression. Treatment with kaempferol significantly lowered myocardin levels in uterine fibroid tissue compared to normal uterine smooth muscle (PKaempferol might be used for clinical treatment of uterine fibroids due to its inhibitory effect on the proliferation of uterine fibroids cells.

  12. PSEUDO CENTRAL CERVICAL FIBROID IN A NULLIPAROUS GIRL: A CASE REPORT

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    Priyankur

    2014-08-01

    Full Text Available Fibroids are benign (non-cancerous growths on the uterus. There is an overall incidence of 20% in women more than 30yrs of age. The incidence of cervical fibroids is much lower at 1-2%. An unmarried girl presented with complaints of difficulty in passing urine, lower abdominal pain and spasmodic dysmenorrhea for 4 months. Per abdomen there was a firm, non-tender midline mass arising from the pelvis corresponding to 20 weeks size gravid uterus with restricted mobility. Cervix could not be felt. Ultrasonographic examination showed 10.2x10.7 cm fibroid in the posterior wall with no adnexal pathology and bilateral mild hydronephrosis. On laparotomy, the uterus was found to be sitting like a lantern on the dome of St. Paul's Cathedral. A 25x18 cm pseudo central cervical fibroid, partly intramural, partly sub mucous was seen to arise from the posterior cervico isthmic region. Myomectomy was performed successfully. Central cervical fibroid expands the cervix equally in all directions and the uterus is elevated on top of the large tumor. Diagnosis is by ultrasonogram and HSG. Management in cervical fibroid of supravaginal portion is hysterectomy if fertility is not desired and myomectomy if the patient is young and fertility is desired, as in our case.

  13. Chronic anorexia and weight loss due to extensive fibroid compression of the bowel: an unusual complication of uterine fibroids in a patient with a twin pregnancy.

    Science.gov (United States)

    Narayan, Bhaskar; McCarthy, Fergus; Nelson-Piercy, Catherine

    2016-05-05

    A 36-year-old homeless Eritrean nulliparous woman was admitted to hospital, with abdominal pain, nausea and loss of appetite. She was found to be 17 weeks pregnant with dichorionic diamniotic twins. She was cachectic and had large palpable uterine fibroids. An extensive search for infection and malignancy did not yield any significant results. She was managed with enteral nutritional support and delivered healthy twins by emergency caesarean section at 36 weeks' gestation. She re-presented 19 days postpartum, with fever and abdominal pain. Imaging revealed multiple abdominal collections and large degenerating fibroids. At laparotomy, the fibroids were found to be adherent to, compressing and enveloping large sections of bowel. The patient required a right hemicolectomy, small bowel resection and total abdominal hysterectomy. Histology confirmed an infarcted leiomyoma and the patient made a good postoperative recovery.

  14. Establishment of a scoring system for predicting the difficulty level of high-intensity focussed ultrasound ablation of uterine fibroids.

    Science.gov (United States)

    Liu, Zhongqiong; Gong, Chunmei; Liu, Yunchang; Zhang, Lian

    2017-05-19

    To establish a scoring system that predicts the difficulty level of high-intensity focussed ultrasound (HIFU) ablation of uterine fibroids. Four hundred and twenty-two patients with fibroids were enrolled. The energy efficiency factor (EEF) and sonication time were set as dependent variables, with factors possibly affecting EEF and sonication time including age, body mass index (BMI), the volume of fibroids, the location of the uterus, the type of fibroids, the signal intensity on the T2-weighted imaging (T2WI), the enhancement type, the thickness of the rectus abdominis and the subcutaneous fat layer, the distance from the anterior/posterior surface of the fibroid to the skin, and the abdominal wall scars were set as predictors for building optimal scaling regression models. The volume of the fibroids, the location of the uterus, the signal intensity on T2WI, enhancement type, rectus abdominis thickness, subcutaneous fat thickness, and distance from the anterior surface of fibroid to the skin were related to EEF. Signal intensity on T2WI, the volume of fibroids, distance from the posterior surface of fibroid to the skin, and enhancement type were related to sonication time. Models that can predict the difficulty level of HIFU for fibroids have been established: for EEF, y ' = 0.338X '1 - 0.231X '2+0.156X '3+0.167X '4 ; for sonication time, y = 0.227X1+0.321X2+0.157X3+0.194X4. A scoring system for predicting the difficulty level of HIFU treatment for uterine fibroids has been established and it can be used to help select patients and to predict the sonication time for a given fibroid.

  15. Ovarian protection by selective coil embolization of a uteroovarian anastomosis before uterine fibroid embolization: a report of two cases

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung Boo; Im, Han Hyeok [Soonchunhyang University, Gumi (Korea, Republic of); Chang, Yun Woo; Goo, Dong Erk [Soonchunhyang University Hospital, Gumi (Korea, Republic of)

    2006-09-15

    Premature menopause can be developed as a result of undesired nontarget ovary embolization during the performance of uterine fibroid embolization. The etiology of varian failure after uterine fibroid embolization is not yet clearly defined, but one of the leading possibilities is nontarget embolization of the varies. We report here on two cases in which superselective coil embolization of distal uterine artery collateral pathways to the ovary was performed during uterine fibroid embolization.

  16. INFLAMMATORY FIBROID POLYPS OF GASTRO-INTESTINAL TRACT

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective: To review the diagnosis and differential diagnosis of inflammatory fibroid polyp (IFP) of gastrointestinal tract. Methods: The clinical symptoms, histopathologic features and immunohistochemical (ABC method) staining in 9 cases were observed. Results: IFP presented either as a solitary pedunculated or sessile lesion arising from the submucosa and protroding into the lumen; composed of a background of fibroblasts and blood vessels infiltrated by a variable number of inflammatory cells, often numerous eosinophilias leukocytes. Immunohistochemical staining: the spindle cells of all cases reacted with Vimentin. The partial cells of several cases react with Actin, NSE, a -AT. 7 cases were follow-up. No patients had a recurrence of the lesion. Conclusion: IFP are rare lesions, and may represent an exaggerated response to inflammatory or other injury process. The prognosis is good when treated by segmental resections of endoscopic removals.

  17. Safe laparoscopic removal of a 3200 gram fibroid uterus.

    Science.gov (United States)

    Demir, Richard H; Marchand, Gregory J

    2010-01-01

    Hysterectomy using minimally invasive techniques yields fewer complications, less blood loss, and quicker recovery time compared with traditional abdominal hysterectomy. Despite these advantages, 65% of all hysterectomies in the United States are still performed using traditional laparotomy, and many clinicians still exclude patients with a history of prior abdominal surgery, significant obesity, or a large fibroid uterus from these procedures. Among physicians skilled in minimally invasive surgery, the prior largest uteri removed included a 2421g uterus removed vaginally, and a 2418g uterus removed via hand-assisted laparoscopic hysterectomy. We performed a laparoscopic-assisted hysterectomy on a significantly obese 50-year-old woman with a 3200g uterus. The patient required a 2-day hospital stay and recovered unremarkably. The patient was able to return to work within one week and quickly returned to activities of daily life. In the hands of experienced minimally invasive surgeons, laparotomy can be avoided in almost all instances of hysterectomy for benign disease.

  18. Inflammatory Fibroid Polyp Causing Colocolic Intussusception in an Infant

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    Mark Walton

    1994-01-01

    Full Text Available A three-month-old infant presented to the emergency department with a 24 h history of irritability and lesion prolapsing intermittently per anus. The child had a six-week history of blood and mucus per rectum. Digital rectal examination and sigmoidoscopy revealed what appeared to be a large mobile polypoid lesion arising from the rectum. Plans for excision were made. Sigmoidoscopy performed the following morning failed to demonstrate any lesion in the rectum or sigmoid. Barium enema demonstrated a sessile ‘apple core type’ lesion in the descending colon. Segmental resection of the descending colon with end-to-end anastomosis was performed. Pathological examination of the resected bowel demonstrated features consistent with an inflammatory fibroid polyp. This case appears to be unique because of the young age of the patient, its unusual location and its presentation as an intermittent colocolic intussusception.

  19. Aberrant Methylation of the E-Cadherin Gene Promoter Region in the Endometrium of Women With Uterine Fibroids.

    Science.gov (United States)

    Li, Yan; Ran, Ran; Guan, Yingxia; Zhu, Xiaoxiong; Kang, Shan

    2016-08-01

    A uterine fibroid is a leiomyoma that originates from the smooth muscle layer of the uterus. A variety of endometrial abnormalities are associated with uterine fibroids. This study aims to investigate the methylation status of the E-cadherin gene (CDH1) promoter region in the endometrium of patients with uterine fibroids. The methylation of CDH1 was studied using methylation-specific polymerase chain reaction in the endometrial tissue of 102 patients with uterine fibroids and 50 control patients. The E-cadherin expression was examined by flow cytometry. The methylation rate of CDH1 promoter region was 33.3% in the endometrium of patients with uterine fibroids and 8% in the endometrium of women without fibroids. The frequency of CDH1 promoter methylation in the endometrium of patients with fibroids was significantly higher than that in the endometrium of women without fibroids (P = .001). Furthermore, the E-cadherin expression level in methylation-positive tissues was significantly lower than that in methylation-negative tissues (P = .017). These results suggest that epigenetic aberration of CDH1 may occur in the endometrium of patients with fibroids, which may be associated with E-cadherin protein expression in endometrial tissue.

  20. Hypovitaminosis D and “small burden” uterine fibroids: Opportunity for a vitamin D supplementation

    Science.gov (United States)

    Ciavattini, Andrea; Delli Carpini, Giovanni; Serri, Matteo; Vignini, Arianna; Sabbatinelli, Jacopo; Tozzi, Alessandra; Aggiusti, Alice; Clemente, Nicolò

    2016-01-01

    Abstract The aim of this study was to evaluate the effect of vitamin D supplementation in women with hypovitaminosis D and “small burden” uterine fibroids. This study focused on 208 women diagnosed with uterine fibroids and concomitant hypovitaminosis D, from January to December 2014. One hundred eight women of the initial study population were diagnosed with “small burden” uterine fibroids. Among them, those who underwent a proper vitamin D supplementation constituted the “study group” (n = 53), while women who spontaneously refused the therapy or did not perform it properly, constituted the “control group” (n = 55). The characteristics of uterine fibroids, the fibroid-related symptoms, and the vitamin D serum levels were evaluated 12 months after the initial diagnosis. In women with uterine fibroids, a negative correlation emerged between the baseline 25-hydroxy-cholecalciferol (25-OH-D3) concentration and both the volume of the largest fibroid (r = −0.18, P = 0.01) and the total volume of fibroids (r = −0.19, P = 0.01). No correlation was found between the baseline 25-OH-D3 levels and the number of fibroids per patient (r = −0.10, P = 0.16). In women of the “study group,” a significant increase in the 25-OH-D3 serum level was observed after 12 months of supplementation, and a lower rate of surgical or medical treatment due to the “progression to extensive disease” was reported (13.2% vs 30.9%, P = 0.05). Supplementation therapy with 25-OH-D3 restores normal vitamin D serum levels in women with “small burden” fibroids. In these women, vitamin D supplementation seems to reduce the progression to an extensive disease, and thus the need of conventional surgical or medical therapy. PMID:28033263

  1. Use of Chinese Medicine and Subsequent Surgery in Women with Uterine Fibroid: A Retrospective Cohort Study

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    Shan-Yu Su

    2012-01-01

    Full Text Available Background. Chinese medicine (CM has been used to relieve symptoms relevant to uterine fibroids. Objective. This study investigated the association between the use of CM and the incidence of uterine surgery in women with uterine fibroids. Subjects and Methods. This retrospective cohort study extracted records for 16,690 subjects diagnosed with a uterine fibroid between 2000 and 2003 from the National Health Insurance reimbursement database. The risk factors for surgery were examined via Cox proportional hazard analysis, and the difference in incidence of surgery between CM users and nonusers was compared using incidence rate ratios (IRRs derived from Poisson's models. Results. After an average follow-up period of 4.5 years, the cumulative incidence of uterine surgery was significantly lower in CM users than CM nonusers (P<0.0001. Compared to CM nonusers, CM users were more unlikely to undergo uterine surgery (adjusted hazard ratio = 0.18, 95% confidence interval (CI = 0.17, 0.19. The incidence of surgery in CM users was dramatically different from that for CM nonusers (IRR = 0.17, 95% CI = 0.16, 0.18. Conclusion. The risk of uterine surgery among fibroid patients who used CM was significantly decreased, implying an effective treatment of fibroid-related symptoms provided by CM.

  2. ROLE OF MIFEPRISTONE IN MEDICAL MANAGEMENT OF UTERINE FIBROID

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    Shradha

    2015-10-01

    Full Text Available BACKGROUND: Uterine leiomyoma is the most common benign tumour of uterus affecting women of reproductive age group and accounting for most common indication of hysterectomy in India. Effective medical treatment option can prevent hysterectomy related morbidity. MATERIALS AND METHODS: A total of 50 women with symptomatic leiomyoma and asymptomatic with uterine volume >160cc and fibroid size >2.5cm were included in the study. 20mg/day mifepristone was given to them over period of 3 months. Follow up was done at 1, 3 and 6 months of starting treatment. At each visit patients were evaluated for symptomatic improvement of menorrhagia, dysmenorrhoea and ultrasound for myoma volume, haemogram was done. Endometrial biopsy was done at the beginning of therapy, 3rd month and at end of treatment. RESULTS: At the beginning of study, all patients had menorrhagia. At 3 months, 80% developed amenorrhea and 20% scanty menses. At 6 months, 56% had scanty menses and 38% had normal menses but none had menorrhagia. 50% of patients had dysmenorrhoea at the beginning of study with severe dysmenorrhoea in 36% of cases. Only 10% of patients at 3 months and 14% at 6 months had dysmenorrhoea. Improvement in haemoglobin percentage from 9.6 gram% to 10.8 gram% at 3 months of therapy. The reduction in mean uterine volume was 12.28%after 1 month, 26.95% after 3 months and 11.13% at end of 6 months, as compared to pre-treatment level. Fibroid volume decreased by 14.34% after 1 month ,29.8% after 3 months and 24.98% at end of 6 months, as compared to pre-treatment level. At the end of 3 months, 50% of patients experienced no side effect. Rest 50% experienced minor side effects like nausea (8%, hot flushes (4%, liver dysfunction as evidenced by mild increase in transaminase (8% and simple endometrial hyperplasia in 30%. Follow up of these patients at 6 month i.e., 3 months after stopping the drug does not show any evidence of persistence of these effects. CONCLUSION: 20mg

  3. Clinical 3-year follow-up of uterine fibroid embolization; Klinische 3-Jahres-Ergebnisse nach Uterusmyomembolisation

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    Radeleff, B.A.; Satzl, S.; Eiers, M.; Fechtner, K.; Hakim, A.; Kauffmann, G.W.; Richter, G.M. [Universitaetsklinikum Heidelberg (Germany). Abt. Radiodiagnostik; Rimbach, S. [Klinikum Konstanz (Germany). Frauenklinik

    2007-06-15

    Purpose: The purpose of this study was to evaluate the clinical long-term success of uterine artery embolization (UAE) in patients with symptomatic fibroids using spherical particles (Embosphere). Materials and Methods: 34 consecutive patients treated with UAE were initially enrolled in the study which had the following study goals (1) 1-year follow-up MRI evaluation of the fibroid behavior and (2) clinical long-term success due to standardized assessment of the main fibroid-related symptoms (hypermenorrhoea, dysmenorrhoea and dysuria) of the patients' individual overall health status and their therapy satisfaction at 1-year, 2- year and 3-year intervals after UAE. Results: Technical success was achieved in all procedures. Four patients had to be excluded from the long-term evaluation schedule: one because of a hysterectomy due to bleeding after 6 weeks, 3 patients were not available for the designated minimum follow-up interval. The preinterventional severe hypermenorrhoea (n = 27) with a score of 4.4 {+-} 0.7 (5 = extreme menstrual bleeding) decreased after one year to 2.1 {+-} 0.5 (p = 0.0001), after two years to 1.7 {+-} 0.5 (p = 0.0042) and after three years to 1.3 {+-} 0.6 (p = 0.0001). The preinterventional dysmenorrhoea (n = 15) with a score of 3.1 {+-} 1.5 (3 = distinctly increased dysmenorrhoea) decreased after one year to 1.1 {+-} 0.3 (p = 0.0001), after two years to 1.2 {+-} 0.2 and after three years to 1.2 {+-} 0.4 (p = 0.148). The pretreatment dysuria (n = 12) with a preinterventional score of 3.1 {+-} 1.5 (3 = distinctly increased dysuria) decreased after one year to 1.1 {+-} 0.3 (p = 0.0069) and remained after two years at 1.1 {+-} 0.2 and after three years at 1.2 {+-} 0.4 (p = 0.905). The initial overall health status was 54.7 {+-} 20.1 (maximal value 100). After one year it rose to 90.5 {+-} 15.4 (p = 0.0001), was 91.8 {+-} 5.6 after two years and was 91.3 {+-} 8.5 (p = 0.8578) after three years. The satisfaction with the therapy was 2

  4. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatment for uterine fibroids

    Science.gov (United States)

    Abdullah, BJJ; Subramaniam, RV; Omar, SS; Wragg, P; Ramli, N; Wui, AL; Lee, CC; Yusof, Y

    2010-01-01

    Magnetic Resonance-guided focused Ultrasound Surgery (MRgFUS) is gaining popularity as an alternative to medical and surgical interventions in the management of symptomatic uterine fibroids. Studies have shown that it is an effective non-invasive treatment with minimal associated risks as compared to myomectomy and hysterectomy. MRgFUS can be offered to a majority of patients suffering from symptomatic uterine fibroids. It has been suggested that the use of broader inclusion criteria as well as the mitigation techniques makes it possible to offer MRgFUS to a much larger subset of patients than previously believed. This paper will describe how MRgFUS treatment for uterine fibroids is performed at the University of Malaya Medical Centre, Kuala Lumpur, Malaysia. PMID:21611036

  5. Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps.

    Science.gov (United States)

    Albuquerque, Andreia; Rios, Elisabete; Carneiro, Fátima; Macedo, Guilherme

    2014-12-01

    Inflammatory fibroid polyps are rare mesenchymal lesions. The frequency of Helicobacter pylori infection in the gastric mucosa overlying inflammatory fibroid polyps and its relation with the histologic features of the polyps are undetermined. The clinico-pathological features of inflammatory fibroid polyps, the frequency of Helicobacter pylori infection in the overlying gastric mucosa, and its putative impact on the phenotype of the polyps were evaluated. Gastric inflammatory fibroid polyps diagnosed in our Hospital from 1998 to 2012 were reviewed and the histological. The histological sections were stained with hematoxylin and eosin and modified Giemsa for the evaluation of Helicobacter pylori infection. Inconclusive cases were further analyzed by immunohistochemistry with anti-Helicobacter pylori antibody. Diagnosis was confirmed in 54 polyps, 85 % developed in females, mean age 63 ± 11 years. Most polyps were sessile (74 %), with a mean size of 15 ± 12 mm, 96 % were located in the antrum and 85 % were removed by snare polypectomy. Helicobacter pylori infection was identified in 48 % of the polyps. Most inflammatory fibroid polyps developed in the submucosa, and mucosal extension was observed in 96 % of the cases. Chronic gastritis was observed in all cases (63 % with activity, 31 % with intestinal metaplasia, and 61 % with foveolar hyperplasia). Erosion and ulceration of the overlying gastric mucosa was observed in 48 % and 11 % of the polyps, respectively. Onion skin features were present in 52 % of the polyps and were more frequently observed in cases without evidence of Helicobacter pylori infection. Background changes in gastric mucosa were not distinctive according to Helicobacter pylori infection. Chronic atrophic gastritis with intestinal metaplasia was associated with the presence of perivascular onion skin lesions. To our knowledge, this is the second largest series of gastric inflammatory fibroid polyps. Helicobacter pylori infection was

  6. Inflammatory fibroid polyp occurring in the transverse colon diagnosed by endoscopic biopsy

    Institute of Scientific and Technical Information of China (English)

    Shoji Hirasaki; Minoru Matsubara; Fusao Ikeda; Hideaki Taniguchi; Seiyuu Suzuki

    2007-01-01

    A case of an inflammatory fibroid polyp occurring in the transverse colon and diagnosed by endoscopic biopsy is reported. The patient was an 82-year-old man who visited our hospital for further evaluation of occult blood in stool. The Colonoscopy revealed a small,red, and peduncular polyp, about 6 mm in diameter,in the transverse colon. Histological examination of the biopsy specimen obtained from the polyp revealed proliferation of fibroblasts and infiltration of inflammatory cells such as plasma cells and eosinophils. This polyp was diagnosed as an inflammatory fibroid polyp, which can appear in many different locations throughout gastrointestinal tract, though still rare in the transverse colon.

  7. Association between menarche age and menstrual disorder with the incidence of uterine fibroid in medan, Indonesia: based on hospital data

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    Muhammad Fidel Ganis Siregar

    2015-08-01

    Full Text Available Background: Uterine fibroids are benign, monoclonal tumors of the smooth muscle cells found in the human uterus. The incidence of uterine fibroid in Indonesia is between 2.39% - 11.7% in all gynecology inpatient. Despite the fact that their cause is still unknown, there is considerable evidence that estrogens and progestogens proliferate tumor growth, as the fibroids rarely appear before menarche and regress after menopause. Methods: An observational analytic study with case control approach. Total sample from this study was 498 people, with 249 cases and 249 controls. The samples were collected through purposive sampling. The study was conducted in the medical record division of Adam Malik General Hospital Medan. Results from the study were analyzed with chi square. Results: The result of this study demonstrated an association between menarche age with uterine fibroid incidence, with a p-value < 0.05, and odds ratio = 2.487 (CI 1.585-3.902. This indicate that the incidence of uterine fibroid is 2.5 greater in women with menarche age of < 10 years old. P-value < 0.05 and odds ratio = 0.258 (CI 0.178-0.375 were obtained from the association between menstrual disorder and uterine fibroid incidence. Conclusions: The result of this study demonstrates a significant association correlation between menarche age and the development of uterine fibroid. Early menarche age increases risk of uterine fibroid incidence, whereas menstrual disorder is more likely a clinical manifestation of uterine fibroid, rather than a risk factor. [Int J Reprod Contracept Obstet Gynecol 2015; 4(4.000: 1025-1028

  8. Bleeding versus Clotting: A Complex Case of a Large Fibroid Uterus Causing Menorrhagia and a DVT

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    Sangeeta Ramanan

    2016-01-01

    Full Text Available A 43-year-old woman presented with severe anaemia secondary to menorrhagia. Pelvic ultrasound showed a large intramural posterior fundal fibroid. Hysteroscopy showed the fibroid distorting the endometrial cavity, precluding Mirena® device insertion. As she was initially hesitant to have a hysterectomy, medical management with the oral contraceptive pill (OCP and tranexamic acid was instituted, with good effect. Months later, after a long road trip, she presented with left leg swelling, and a Doppler ultrasound confirmed an extensive deep vein thrombosis (DVT. She was commenced on warfarin for anticoagulation but presented again with menorrhagia precipitated by overanticoagulation. After initial stabilization with multiple blood transfusions and reversal of anticoagulation, the warfarin was ceased in favour of enoxaparin and she underwent inferior vena cava (IVC filter insertion prior to a total abdominal hysterectomy. Mass effect from large uterine fibroids can cause venous thromboembolism (VTE. A duplex ultrasound of the lower limbs if a woman presents with a large fibroid could identify asymptomatic DVTs in such women. A prehysterectomy IVC filter would then reduce their risk of postoperative pulmonary embolism. Medical management of menorrhagia with procoagulants should be avoided for management of menorrhagia in such women given their higher risk of developing VTE.

  9. Persistent organic pollutants (POPs) and fibroids: results from the ENDO Study

    Science.gov (United States)

    Trabert, Britton; Chen, Zhen; Kannan, Kurunthachalam; Peterson, C. Matthew; Pollack, Anna Z.; Sun, Liping; Buck Louis, Germaine M.

    2015-01-01

    To evaluate the association between persistent organic pollutants (POPs) and uterine fibroids we used previously collected data from a cohort of women 18–44 years of age undergoing laparoscopy or laparotomy at 14 participating hospital surgical centers (n=473). POP concentrations were measured in omental fat and serum. Presence of fibroids was defined based on a postoperative diagnosis (n=99). Odds ratios (OR) and 95% confidence interval (CI) for each POP by biologic medium was estimated using unconditional logistic regression adjusted for identified covariates. Concentrations were higher in omental fat than in serum for all POPs. Serum p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) was the only POP associated with fibroids [per 1-SD increase in log-transformed p,p′-DDE OR (95% CI): 1.37 (1.05–1.80)]. In analyses excluding women diagnosed with endometriosis, a number of polychlorinated biphenyls (PCBs) measured in omental fat were associated with fibroids [PCB 99: 1.64 (1.08, 2.49); PCB 138: 1.64 (1.03, 2.59); PCB 146: 1.54 (1.01, 2.37); PCB 153: 1.88 (1.12, 3.13); PCB 196: 1.60 (1.02, 2.51); PCB 206: 1.52 (1.01, 2.29)]. Although exploratory, our study suggests that PCBs may be associated with fibroids in the absence of other gynecologic disorders such as endometriosis, but the associations varied by biologic media with more POPs emerging when quantified in fat. PMID:24802554

  10. Uterine Artery Embolization for Symptomatic Uterine Fibroids: a Prospective Study on 102 Patients in Iran

    Directory of Open Access Journals (Sweden)

    M. Shakiba

    2005-06-01

    Full Text Available Background/Objectives : To evaluate the safety, efficacy an d complication rate of uterine artery embolization in symptomatic fibroid patients in Iran. Patients and Methods: A hundred and two patients aged 20-48 years (mean age: 35.7 ±6.4 years with symptomatic fibroids entered th e study from September 2001 to November 2004. The most common presenting symptom was increased menstrual bleeding, which occurred in 74.5% of all patients. Urinary symptoms occurred in 43%, and bulk-related symptoms were seen in 63.7 % of our patients. We performed bilateral UAE (uterine artery em bolization using PVA (pol yvinyl alcohol particles (500-710 micron and assessed the patients before UAE and at regular follow- ups at 1, 3, 6 and 12-month intervals by questionnaires / interviews and ultrasound. MRI without gadolinium (Gd-DTPA injection was done before emboliz ation and at 6 and 12 months after the procedure. Results: By Friedman test, sequential follow-up (up to 12 months showed that the vaginal bleeding severity significantly decreased (p <0.0001, with menorrhagia resolving in 59.4% of patients at 1 month, and in 69% at 12 months. The mean uterus volume decreased 38.5 ±30% after 12 months .The paired t-test showed that dominant fibroid volume changed from 273.7±439.2 cm3 to 112.1±141.6 cm3 at month 6 (n=58, p=0.001 and from 246.1±314.5 cm3 to 70.1±73.5 cm3 at month 12 (n=41, p<0.0001 . The initial size of the fibroids did not affect the success rate. Conclusion: The study showed the high efficacy of UAE in controlling fibroid related symptoms, with only few complications.

  11. A Split-and-Merge-Based Uterine Fibroid Ultrasound Image Segmentation Method in HIFU Therapy.

    Directory of Open Access Journals (Sweden)

    Menglong Xu

    Full Text Available High-intensity focused ultrasound (HIFU therapy has been used to treat uterine fibroids widely and successfully. Uterine fibroid segmentation plays an important role in positioning the target region for HIFU therapy. Presently, it is completed by physicians manually, reducing the efficiency of therapy. Thus, computer-aided segmentation of uterine fibroids benefits the improvement of therapy efficiency. Recently, most computer-aided ultrasound segmentation methods have been based on the framework of contour evolution, such as snakes and level sets. These methods can achieve good performance, although they need an initial contour that influences segmentation results. It is difficult to obtain the initial contour automatically; thus, the initial contour is always obtained manually in many segmentation methods. A split-and-merge-based uterine fibroid segmentation method, which needs no initial contour to ensure less manual intervention, is proposed in this paper. The method first splits the image into many small homogeneous regions called superpixels. A new feature representation method based on texture histogram is employed to characterize each superpixel. Next, the superpixels are merged according to their similarities, which are measured by integrating their Quadratic-Chi texture histogram distances with their space adjacency. Multi-way Ncut is used as the merging criterion, and an adaptive scheme is incorporated to decrease manual intervention further. The method is implemented using Matlab on a personal computer (PC platform with Intel Pentium Dual-Core CPU E5700. The method is validated on forty-two ultrasound images acquired from HIFU therapy. The average running time is 9.54 s. Statistical results showed that SI reaches a value as high as 87.58%, and normHD is 5.18% on average. It has been demonstrated that the proposed method is appropriate for segmentation of uterine fibroids in HIFU pre-treatment imaging and planning.

  12. Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids : 10-year outcomes from the randomized EMMY trial

    NARCIS (Netherlands)

    de Bruijn, Annefleur M.; Ankum, Willem M.; Reekers, Jim A.; Birnie, Erwin; van der Kooij, Sanne M.; Volkers, Nicole A.; Hehenkamp, Wouter J. K.

    2016-01-01

    BACKGROUND: Since 1995 uterine artery embolization has been described as an alternative for hysterectomy in patients with symptomatic fibroids. Many studies including several randomized controlled trials established uterine artery embolization as a valuable treatment. These randomized controlled

  13. Scaled signal intensity of uterine fibroids based on T2-weighted MR images: a potential objective method to determine the suitability for magnetic resonance-guided focused ultrasound surgery of uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun [CHA University, Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, Gyunggi-do (Korea, Republic of); Yoon, Sang-Wook [CHA University, Department of Diagnostic Radiology, CHA Bundang Medical Center, Sungnam-si, Gyunggi-do (Korea, Republic of); Sokolov, Amit [InSightec Ltd., Haifa (Israel)

    2015-12-15

    Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive method to treat uterine fibroids. To help determine the patient suitability for MRgFUS, we propose a new objective measure: the scaled signal intensity (SSI) of uterine fibroids in T2 weighted MR images (T2WI). Forty three uterine fibroids in 40 premenopausal women were included in this retrospective study. SSI of each fibroid was measured from the screening T2WI by standardizing its mean signal intensity to a 0-100 scale, using reference intensities of rectus abdominis muscle (0) and subcutaneous fat (100). Correlation between the SSI and the non-perfused volume (NPV) ratio (a measure for treatment success) was calculated. Pre-treatment SSI showed a significant inverse-correlation with post treatment NPV ratio (p < 0.05). When dichotomizing NPV ratio at 45 %, the optimal cut off value of the SSI was found to be 16.0. A fibroid with SSI value 16.0 or less can be expected to have optimal responses. The SSI of uterine fibroids in T2WI can be suggested as an objective parameter to help in patient selection for MRgFUS. (orig.)

  14. PROMISe trial: a pilot, randomized, placebo-controlled trial of magnetic resonance guided focused ultrasound for uterine fibroids.

    Science.gov (United States)

    Jacoby, Vanessa L; Kohi, Maureen P; Poder, Liina; Jacoby, Alison; Lager, Jeanette; Schembri, Michael; Rieke, Viola; Grady, Deborah; Vittinghoff, Eric; Coakley, Fergus V

    2016-03-01

    To evaluate the feasibility of a full-scale placebo-controlled trial of magnetic resonance-guided focused ultrasound for fibroids (MRgFUS) and obtain estimates of safety and efficacy. Pilot, randomized, placebo-controlled trial. University medical center. Premenopausal women with symptomatic uterine fibroids. Participants randomized in a 2:1 ratio to receive MRgFUS or placebo procedure. change in fibroid symptoms from baseline to 4 and 12 weeks after treatment assessed by the Uterine Fibroid Symptom Quality of Life Questionnaire (UFS-QOL); secondary outcome: incidence of surgery or procedures for recurrent symptoms at 12 and 24 months. Twenty women with a mean age of 44 years (±standard deviation 5.4 years) were enrolled, and 13 were randomly assigned to MRgFUS and 7 to placebo. Four weeks after treatment, all participants reported improvement in the UFS-QOL: a mean of 10 points in the MRgFUS group and 9 points in the placebo group (for difference in change between groups). By 12 weeks, the MRgFUS group had improved more than the placebo group (mean 31 points and 13 points, respectively). The mean fibroid volume decreased 18% in the MRgFUS group with no decrease in the placebo group at 12 weeks. Two years after MRgFUS, 4 of 12 women who had a follow-up evaluation (30%) had undergone another fibroid surgery or procedure. Women with fibroids were willing to enroll in a randomized, placebo-controlled trial of MRgFUS. A placebo effect may explain some of the improvement in fibroid-related symptoms observed in the first 12 weeks after MRgFUS. NCT01377519. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  15. Uterine restoration after repeated sloughing of fibroids or vaginal expulsion following uterine artery embolization

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hye Ri; Kim, Nack Keun; Lee, Mee Hwa [Pochon CHA University, Department of Obstetrics and Gynecology, Bundang CHA General Hospital, Sungnam-si, Kyonggi-do (Korea); Kim, Man Deuk; Kim, Hee Jin; Yoon, Sang-Wook [Pochon CHA University, Department of Diagnostic Radiology, Bundang CHA General Hospital, Sungnam-si, Kyonggi-do (Korea); Park, Won Kyu [Yeungnam University, Department of Diagnostic Radiology, Kyongson, Dyongbuk (Korea)

    2005-09-01

    The aim of our study is to present our experience with uterine restoration after repeated sloughing of uterine fibroids or transvaginal expulsion following uterine artery embolization (UAE) and to determine its safety and outcome. One hundred and twenty-four women (mean age, 40.3 years; age range, 29-52 years) with symptomatic uterine fibroids were included in this retrospective study. We performed arterial embolization with poly(vinyl alcohol) particles (250-710 {mu}m). Clinical symptoms and follow-up information for each patient were obtained through medical records. At an average of 3.5 months (range, 1-8 months) after embolization, magnetic resonance imaging examinations with T1- and T2-weighted and gadolinium-enhanced T1-weighted images were obtained for all patients. The mean follow-up duration was 120 days (90-240 days). Eight (6.5%) patients experienced uterine restoration after repeated sloughing of uterine fibroids or spontaneous transvaginal expulsion. The locations of the leiomyomas were submucosal (n=5), intramural (n=2) and transmural (n=1). The maximum diameter of the fibroids ranged from 3.5 to 18.0 cm, with a mean of 8.4 cm. The time interval from embolization to the uterine restoration was 7-150 days (mean 70.5 days). The clinical symptoms before and during vaginal sloughing or expulsion were lower abdominal pain (n=4), vaginal discharges (n=3), infection of necrotic myomas (n=2) and cramping abdominal pain (n=1). Gentle abdominal compression (n=1) and hysteroscopic assistance (n=1) were required to remove the whole fibroid. No other clinical sequelae, either early or delayed, were documented. Magnetic resonance images revealed the disappearance of leiomyomas, intracavitary rupture resulting in transformation of intramural or transmural myomas into submucosal myomas and localized uterine wall defects. Although the small size of this study precludes a strict conclusion, there appear to be few serious complications directly related to vaginal

  16. Prospective study on magnetic resonance-guided focused ultrasound surgery for symptomatic uterine fibroid : short-term follow up%MRI引导的聚焦超声术治疗症状性子宫肌瘤的前瞻性研究

    Institute of Scientific and Technical Information of China (English)

    范融; 朱兰; 龚晓明; 薛华丹; 石海峰; 金征宇; 陈广俊

    2013-01-01

    的HRQL评分分别为(74±15)、(82±13)、(89±10)分,术后较术前明显提高,差异也有统计学意义(P<0.01).(5)治疗前后血红蛋白水平变化:治疗前11例患者贫血,平均血红蛋白为(87±6) g/L,治疗后3个月及1年时的血红蛋白含量分别为(106±14)、(112±10) g/L,术后较术前血红蛋白含量明显升高,差异有统计学意义(P<0.01).结论 MRgFUS是治疗症状性子宫肌瘤安全的无创疗法,其短期疗效确定,术后1年时子宫肌瘤症状及患者生命质量均明显改善,但两年内有一定的再手术率.%Objective To evaluate the safety and efficacy of magnetic resonance-guided focused ultrasound surgery (MRgFUS) in treatment of symptomatic uterine leiomyoma among Chinese reproductive age women.Methods From April 2010 to April 2012,80 premenopausal women with symptomatic leiomyoma volunteered to participate in this prospective study in Department of Outpatient of Peking Union Medical College Hospital.Among 23 reproductive aged patients with size of uterus less than 16th gestational weeks,2.5 to 10 cm of diameter of myoma,less than 10 myomas and expressing symptoms clearly were treated by MRgFUS.Treatment data,non-perfused volume ratio (NPVR) and adverse events were recorded.After treatment,patients were followed up at 1 week,1,3,6,12 and 24 months,respectively.Patients at initial screening and each time of the follow-up filled out uterine fibroid symptoms quality of life (UFS-QOL),which include symptoms severity score (SSS) and health-related quality of life (HRQL).The volumes of leiomyoma and uterine were evaluated on MRI before and after the treatment (at 6 and 12 months,respectively).Before operation,routine blood test were performed on all patients,anemia patients at 3 months and 1 year after treatment were checked with blood test.Results (1) Treatment data and adverse events:the mean therapeutic temperature was (69 ± 7) ℃,the mean treatment time was (144 ±62) min,the mean NPVR was (62 ±23)%.Adverse events

  17. Safety after extended repeated use of ulipristal acetate for uterine fibroids

    Science.gov (United States)

    Donnez, Jacques; Bouchard, Philippe; Barlow, David H.; Vázquez, Francisco; Skouby, Sven O.; Palacios, Santiago; Tomaszewski, Janusz; Lemieszczuk, Boguslaw; William, Alistair R. W.

    2017-01-01

    Objective To assess long term safety of extended repeated 3-month courses of ulipristal acetate (UPA) 10 mg/day, for up to 8 courses, with focus on endometrial and laboratory safety parameters. Methods This long-term, multi-center, open-label cohort, follow up study consisted of up to 8 consecutive 3-month courses of daily UPA 10 mg, each separated by a drug free period of 2 spontaneous menstrual bleeds. Sixty-four pre-menopausal women, with moderate to severe symptomatic uterine myoma(s) and heavy bleeding were enrolled and were studied for approximately 4 years. The main outcome measures were endometrial histology, laboratory parameters and general safety. Results All data was reported in a descriptive manner with no formal statistical comparisons. In the 64 women, non-physiological changes (mostly cyst formation, epithelial and vascular changes) in endometrial histology at screening and after treatment courses 4 and 8 were observed in 18.0%, 21.4% and 16.3% of biopsies, respectively. After treatment cessation, such changes were observed in 9.1% of biopsies. All endometrial biopsies were benign after course 8. The median endometrial thickness was 7.0 mm, 10–18 days after the start of menses following treatment courses 5–8, compared to 9.0 mm at screening (before UPA treatment). No changes in the number and type of laboratory results outside the normal ranges were observed with the increasing treatment courses. In total, adverse events were reported in 10 (16%), 12 (19%), 8 (14%) and 5 (9%) subjects, during treatment courses 5, 6, 7 and 8, respectively of which the most frequent adverse events were headache and hot flush. Conclusion The results of this study further support the safety profile of extended repeated 3 months treatment of symptomatic fibroids with ulipristal acetate 10 mg/day. Repeated UPA treatment courses did not result in any changes of concern in endometrial histology, endometrial thickness, or laboratory safety measures. PMID:28267814

  18. Pregnancy outcome of a patient following myomectomy performed during first trimester for red degeneration of fibroid

    Directory of Open Access Journals (Sweden)

    Asma Habib

    2016-08-01

    Full Text Available Pain due to red degeneration of fibroid during pregnancy is usually associated with large myomas. Necrobiosis / red degeneration typically manifests itself about midpregnancy when Lhe leiomyoma suddenly becomes acutely painful, enlarged and tender. The common differential diagnosis of this condition are torsion of the pedicle of an ovarian cyst/a leiomyoma, abruplion placentae, acute pyelitis or any abdominal catastrophe. Ultrasound can easily delineate the presence of myomas of mixed echogenicity along with pregnancy and clinical findings usually suggest the diagnosis of pregnancy complicated by red degeneration of fibroid. The acute pain usually subsides within 3-10 days of conservative treatment. Only refractory cases (2% of patients may demand surgical intervention in early gestation with the known risk of miscarriage. Here we report a pregnancy managed at 13 weeks by myomectomy for red degeneration. The patient ultimately delivered a healthy female child at 38 weeks by lower segment caesarean section.

  19. A Case of Pyomyoma following Uterine Fibroid Embolization and a Review of the Literature

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    Chika C. Obele

    2016-01-01

    Full Text Available Background. Since its introduction in 1996, uterine fibroid embolization (UFE has become standard medical practice in the management of symptomatic uterine fibroids. An extremely rare complication, pyomyoma, has been reported only 5 times previously in the literature following UFE. Case. A 37-year-old woman underwent UFE for symptomatic leiomyomas of the uterus. Signs and symptoms of uterine infection ensued, beginning at 6 days following the procedure. Recurrent fevers and increasing leukocytosis despite the intravenous administration of appropriate antibiotics eventually necessitated surgical intervention on postprocedure day #18. Conclusion. An extremely rare complication of UFE is herein presented, pyomyoma, with a review of other reported cases. Commonalities are sought among these few reported cases with the hope of increasing diagnostic acumen in the detection of this disease.

  20. Intususcepción intestinal por pólipo fibroide inflamatorio en una anciana

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    Antonio M. Maya

    2013-10-01

    Full Text Available El pólipo fibroide inflamatorio es un tumor benigno poco frecuente del tubo digestivo, descripto por Vanek en 1949. Son lesiones de etiología desconocida, originadas en la submucosa. Están formadas por células mononucleares y mesenquimatosas con citoplasma fusocelular, con una importante proporción de eosinófilos. Sus síntomas son variables, dependiendo de su localización, y son una r ara causa de intususcepción intestinal en adultos. Presentamos el caso de una mujer de 82 años, que sufrió una rara intususcepción de intestino delgado, originada en un pólipo fibroide inflamatorio.

  1. CT-Monitored Percutaneous Cryoablation of Uterine Fibroids after Uterine Artery Embolization

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    OBJECTIVE To investigate the effects of percutaneous cryoablation on uterine fibroids using computed tomographic (CT) guidance after uterine artery embolization.METHODS Twelve patients who failed to respond to uterine artery embolization were treated using percutaneous cryoablation. All patients had undergone previous uterine artery embolization an average of 1.2 years (0.7~1.6 years) ago. Two cases had abnormal bleeding, and the other 10 suffered from pressure and/or pelvic pain. Myoma diameters were 4 cm to 16.5 cm. By using CT guidance, 2.0, 2.4, 3.0 or 3.8 mm cryoprobes were placed into the fibroid, and two 15~20 min freezing processes were performed. Hemostasis was achieved only by pressing the incisions for several minutes.MR-imaging was performed before the procedure to measure the size and number of fibroid tumors, and follow- up MR-imaging determined the reduction of the lesions.RESULTS All patients were discharged within 48 h of treatment. Almost no hemorrhage was found in all of the cases. No bladder or bowel injury or significant postsurgery pain was reported. Ice spheres were readily visualized at CT. Beam-hardening artifact from the metal probes was present, but did not interfere with the procedure. Myomas regressed up to 76.3% after 12 months of treatment, and the primary symptoms improved in all treated women.CONCLUSION CT-monitored percutaneous cryoablation is an effective and minimally invasive therapy for symptom relief and fibroid shrinkage after the failure of uterine artery embolization.

  2. Evaluation of uterine fibroids as a cause of AUB by pelvic ultrasound

    OpenAIRE

    Handa, Kriti; Tayade, Atul; Kale, Sushilkumar; Phadke, Akshay

    2016-01-01

    The present prospective diagnostic cross sectional was carried out in the Department of Radio-diagnosis from October 2013 to July 2015. A total of 158 patients were included as per the predefined study criteria. Transabdominal and transvaginal sonography was done on all patients and the diagnosis was correlated with final histopathological diagnosis. Clinically, most common pathology diagnosed was fibroid uterus (53.80%). Similarly on  transabdominal and transvaginal sonography, majority (37....

  3. MR-guided high-intensity focused ultrasound treatment of uterine fibroids

    OpenAIRE

    2016-01-01

    Antonia Wiggermann,1 Michael Beldoch,1 Friederike Hoellen,2 Peter Hunold1 1Clinic for Radiology and Nuclear Medicine, 2Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Lübeck, Germany Abstract: Uterine fibroids are benign, encapsulated uterine tumors, representing the most common reason for hysterectomy in premenopausal women. High-intensity focused ultrasound (HIFU; also known as focused ultrasound surgery) is a noninvasive technique leading to tissu...

  4. Cerebral Venous Sinus Thrombosis following Diagnostic Curettage in a Patient with Uterine Fibroid

    Directory of Open Access Journals (Sweden)

    Xiao-Qun Zhu

    2014-01-01

    Full Text Available Cerebral venous sinus thrombosis (CVST is a relatively rare cerebrovascular disease, of which the risk has been documented in patients with numerous conditions. However, CVST has never been previously described in association with the use of a diagnostic curettage in patient with uterine fibroid. Herein, we described a 43-year-old woman who presented with recurrent convulsive seizures and severe and progressive headache 1 day after a diagnostic curettage of the uterus, which was confirmed to be uterine fibroid pathologically later, and her condition subsequently progressed to confusion. Brain magnetic resonance imaging (MRI revealed an acute extensive thrombosis of the left transverse and sigmoid sinus and the ipsilateral cerebellum infarction. Evaluation for primary thrombophilia revealed that an iron deficiency anemia (IDA due to the fibroid bleeding induced menorrhagia together with a diagnostic curettage might be the sole hypercoagulable risk factor identified. Treatment with anticoagulation led to full recovery of her symptoms and recanalization of the thrombosis was proven on magnetic resonance venography (MRV 2 months later. We suggest that CVST should be recognized as a potential complication related to this diagnostic technique, especially in patient with IDA. The early diagnosis and timely treatment would be of significance in improving the prognosis of this potentially lethal condition.

  5. Patient selection guidelines in MR-guided focused ultrasound surgery of uterine fibroids: a pictorial guide to relevant findings in screening pelvic MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang-Wook; Kim, Kyoung Ah [Pochon CHA University Bundang CHA General Hospital, Department of Diagnostic Radiology, College of Medicine, Gyunggi-do (Korea); Lee, Chan; Na, Young-Jeong; Jung, Sang-Geun; Kim, Seung-Jo [Pochon CHA University Bundang CHA General Hospital, Comprehensive Gynecologic Cancer Center, College of Medicine, Gyunggi-do (Korea); Cha, Sun Hee [Pochon CHA University Bundang CHA General Hospital, Department of Obstetrics and Gynecology, College of Medicine, Gyunggi-do (Korea); Yu, Jeong-Sik [YongDong Severance Hospital, Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul (Korea)

    2008-12-15

    Uterine leiomyomas (fibroids), the most common benign tumor in women of childbearing age, can cause symptoms including dysmenorrhea, menorrhagia, urinary symptoms, pain and infertility. Hysterectomy is a common approach to treating uterine fibroids, and less invasive surgical approaches such as myomectomy and uterine artery embolization also have been shown to alleviate symptoms. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is the only totally non-invasive surgical approved method for treating uterine fibroids. In clinical trials, MRgFUS resulted in significant relief of uterine fibroid symptoms. The safe and effective use of MRgFUS is affected by fibroid type and location, position relative to adjacent anatomical structures and the presence of co-existent pelvic disease. Additionally, successful outcomes with MRgFUS have been correlated with the volume of fibroids ablated during the procedure. Thus, selection of patients in whom sufficient fibroid volumes can be treated safely using the MRgFUS system is critical for successful outcomes. The MR images in this pictorial essay provide examples of uterine fibroids for which MRgFUS should be considered and is designed to facilitate the selection of patients for whom MRgFUS is most likely to provide sustained symptom relief. (orig.)

  6. Impact of periodic health examination on surgical treatment for uterine fibroids in Beijing: a case-control study

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    Yang Ling-Ling

    2010-12-01

    Full Text Available Abstract Background During the past 2 decades, there has been a rapid proliferation of "health examination center (HEC" across China. The effects of their services on public's health have not been systemically investigated. This study aimed to assess the impact of periodic health examination (PHE at HEC on surgical treatment for uterine fibroids in Beijing residents. Methods We identified 224 patients with a primary diagnosis of uterine fibroids who had surgical treatment at four Level-1 general hospitals in Beijing, from June 1, 2009 to October 20, 2009. Controls were women who did not have surgery for uterine fibroids, matched (1:1 ratio for age (within 2 years. A standard questionnaire was used to inquire about whether participants had PHE at HEC during the previous 2 years. Results PHE at HEC within 2 years were associated with surgical treatment for uterine fibroids. Odds ratios was 4.05 (95% CI, 2.61-6.29 P Conclusions Our study showed PHE currently provided at HEC in China were associated with significantly increased use of surgical treatment for uterine fibroids in women. Further studies are needed to assess the effects of PHE on clinical as well as on broad societal outcomes in Chinese in contemporary medical settings.

  7. Uterine fibroid embolization with spheric micro-particles using flow guiding: safety, technical success and clinical results; Uterusmyomembolisation mit sphaerischen Mikropartikeln unter Flusssteuerung: Sicherheit, technischer Erfolg und klinische Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Richter, G.M.; Radeleff, B.; Kauffmann, G.W. [Ruprecht-Karls-Univ. Heidelberg, Abt. fuer Radiodiagnostik, Radiologische Universitaetsklinik (Germany); Rimbach, S. [Ruprecht-Karls-Univ. Heidelberg, Univ.-Frauenklinik (Germany); RWTH Aachen, Univ.-Frauenklinik (Germany)

    2004-11-01

    Materials and Methods: Twenty of the first 26 consecutive patients referred for potential UFE were enrolled in the study. Pre-interventional MRI was used to assess morphologic contraindication to UFE. The embolization procedures were performed from a unilateral femoral approach using 4F selective catheters in straight vessels, >2 mm in diameter, and micro-catheters in smaller and tortuous arteries. The endpoint of the 'flow guided' embolization was defined by reaching the angiography 'pruned tree' appearance and sluggish flow in the main stem of the uterine artery. Assessment of morphologic mid term success was done by MRI 10 days, 3 months, 6 months, 9 months and 1 year after UFE. The clinical mid term success was assessed by having questionaires completed for menstrual bleeding, retention of clinical (symptomatic) benefit and quality of life. Results: Technical success was 100%, with 8 minor (2 post-interventional collapses, 2 hematomas, 4 relevant post-embolizations syndromes, 1 spontaneous expulsion of a submucous myoma) and 3 major complications (1 hysterectomy because of vaginal bleeding for 5 weeks, 1 transient amenorrhea and 1 spontaneous expulsion of myoma with transient bleeding requiring admission). In 17 of 19 patients, MRI showed total fibroid devascularization throughout the entire follow-up. The average shrinkage of the dominant fibroid was 71.3% at one year. The menstrual bleeding record in the cohort group fell from an average of 501.6 before treatment to 76.2 points at one year. At the same time, the clinical symptoms significantly improved. The patient satisfaction with the applied therapy was >95% at 1 year. One patient with residual fibroid perfusion underwent a second procedure, which achieved complete devascularization and adequate clinical success at one year. The second patient with incomplete devascularization had a persistent clinical benefit. (orig.)

  8. Medical Therapies for Uterine Fibroids - A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials.

    Directory of Open Access Journals (Sweden)

    Kurinchi S Gurusamy

    Full Text Available Uterine fibroids are common, often symptomatic and a third of women need repeated time off work. Consequently 25% to 50% of women with fibroids receive surgical treatment, namely myomectomy or hysterectomy. Hysterectomy is the definitive treatment as fibroids are hormone dependent and frequently recurrent. Medical treatment aims to control symptoms in order to replace or delay surgery. This may improve the outcome of surgery and prevent recurrence.To determine whether any medical treatment can be recommended in the treatment of women with fibroids about to undergo surgery and in those for whom surgery is not planned based on currently available evidence.Two authors independently identified randomised controlled trials (RCT of all pharmacological treatments aimed at the treatment of fibroids from a list of references obtained by formal search of MEDLINE, EMBASE, Cochrane library, Science Citation Index, and ClinicalTrials.gov until December 2013.Two authors independently extracted data from identified studies.A Bayesian network meta-analysis was performed following the National Institute for Health and Care Excellence-Decision Support Unit guidelines. Odds ratios, rate ratios, or mean differences with 95% credible intervals (CrI were calculated.A total of 75 RCT met the inclusion criteria, 47 of which were included in the network meta-analysis. The overall quality of evidence was very low. The network meta-analysis showed differing results for different outcomes.There is currently insufficient evidence to recommend any medical treatment in the management of fibroids. Certain treatments have future promise however further, well designed RCTs are needed.

  9. Comparison of Two Endovascular Steerable Robotic Catheters for Percutaneous Robot-Assisted Fibroid Embolization.

    Science.gov (United States)

    Del Giudice, C; Pellerin, O; Nouri Neville, M; Amouyal, G; Fitton, I; Leré-Déan, C; Sapoval, M

    2017-09-08

    To compare outcomes of percutaneous robot-assisted uterine fibroid embolization (UFE) using two different endovascular robotic catheters. Twenty-one patients with a symptomatic uterine fibroid were prospectively enrolled in a single-center study to be treated with a percutaneous robot-assisted embolization using the Magellan system. Fourteen patients were treated using a first generation steerable robotic catheter, version 1.0 (group 1), and seven were treated using the new version 1.1 (group 2). Demographic, pathologic, and procedural variables were recorded. Dose Area Product (DAP) and physician equivalent doses were registered for each procedure. Procedural related complications and clinical midterm outcomes were also evaluated. Successful robot-assisted UFE was obtained in eight patients (57.1%) in group 1 and 7 patients (100%) in group 2 (p = 0.01). A successful robot-assisted catheterization of the internal iliac artery anterior branch was performed in all patients of both groups. Median selective target vessel catheterization time was 21.0 ± 12.8 vs 13.4 ± 7 min (p = 0.04) and total fluoroscopy time was 30.3 ± 11.2 vs 19.3 ± 5.9 min, respectively, in group 1 and 2. Mean DAP decreased from 18472.6 ± 15622 to 5469.1 ± 4461.0 cGy·cm(2) (p = 0.04). All patients obtained a symptoms relief at 6 months follow-up. Robot-assisted uterine fibroid embolization is safe and effective. New version of steerable robotic catheter allows performing a faster procedure without related adverse events compared to old version.

  10. Embolização de mioma uterino em mulheres portadoras de miomas volumosos Uterine fibroid embolization in women with giant fibroids

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    Felipe Nasser

    2010-11-01

    ógico. Pode ser considerada uma opção para as pacientes que desejam a preservação uterina e também servir como terapêutica adjuvante à miomectomia de alto risco.PURPOSE: to evaluate the effectiveness of uterine fibroid embolization (UFE in patients with giant fibroids, with regard to both clinical outcomes and size reduction. METHODS: twenty-six patients with a mean age of 36.5 years, carrying symptomatic fibroids with a volume over 1,000 cm³, were referred for UFE. All patients had indication for percutaneous treatment. The procedures were performed under epidural anesthesia and sedation, using an institutional protocol. By unilateral femoral access, selective catheterization of uterine arteries and infusion of calibrated microspheres through microcatheter were carried out. Clinical evaluation was performed by means of regular outpatient gynecology consultation. All patients underwent magnetic resonance imaging (MRI before the procedure and 15 patients underwent control MRI after 6 months. RESULTS: technical success was 100%. There was no complication related to the procedures. Mean uterine volume of the 15 patients studied was 1,401 cm³ before embolization (min 1,045 cm³, max 2,137 cm³ and 799 cm³ after 6 months (525 cm³ min, max. 1,604 cm³, resulting in a total reduction of 42.9%. Clinical improvement was observed in 25 of 26 patients. One woman with uterine volume of 1,098 cm³ who developed necrosis and partial fibroid expulsion underwent myomectomy. Another patient was submitted to myomectomy six months after the procedure because she wanted to become pregnant, despite partial fibroid size reduction. One patient with a uterine volume of 2,201 cm³ required a second intervention to achieve an adequate angiographic result. No patient underwent hysterectomy. On average, 9.2 microsphere syringes were used per patient. CONCLUSION: embolization of giant uterine fibroids is a feasible procedure with acceptable clinical and radiological outcomes. It can be

  11. Safety and Effectiveness of UFE in Fibroids Larger than 10 cm

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    Bérczi, Viktor, E-mail: berczi@hotmail.com; Valcseva, Éva, E-mail: evapeneva@gmail.com; Kozics, Dóra, E-mail: dora.kozics@gmail.com; Kalina, Ildikó, E-mail: ilkalina@t-online.hu; Kaposi, Pál, E-mail: kaposipal@gmail.com [Semmelweis University, Department of Radiology and Oncotherapy (Hungary); Sziller, Péter, E-mail: psziller@t-online.hu; Várbíró, Szabolcs, E-mail: varbiroszabolcs@gmail.com [Semmelweis University, 2nd Department of Gynaecology and Obstetrics (Hungary); Botos, Erzsébet Mária, E-mail: erzsebetbotos@gmail.com [Semmelweis University, Department of Radiology and Oncotherapy (Hungary)

    2015-10-15

    IntroductionEarly literature suggested that the size of the uterus, the size of the dominant fibroid, and the amount of applied embolization particles would be the risk factors for major postprocedural complications, but recent publications have confuted these early results. The purpose of our study was to evaluate whether the size of the dominant fibroid would influence the complication rate and effectiveness in a large single-center cohort.Patients and MethodsFrom 28 April 2008 until 31 December 2012, 303 patients had uterine artery embolization (UAE). 262 patients had small [largest diameter <10 cm (Group 1)], 41 patients had large [largest diameter >10 cm (Group 2)] fibroid. UAE was performed from unilateral femoral access using 500–710 and 355–500 µm polyvinyl alcohol particles. Periprocedural and postprocedural complications and numerical analog quality-of-life scores (0—unbearable symptoms; 100—perfect quality of life) were listed and statistically analyzed.ResultsDuring the mean follow-up time [7.79 ± 5.16 (SD) month], data on 275 patients (275/303 = 90.8 %) were available. Quality-of-life score was 33.3 ± 23.5 and 33.5 ± 24.1 before, whereas 85.6 ± 16.0 and 81.5 ± 23.5 after UAE in Group 1 and Group 2, respectively, (Mann–Whitney U test one-sided, p = 0.365). There were 4 myoma expulsions, 1 acute myomectomy, and 2 acute hysterectomies reported from Group 1, meanwhile 1 myoma expulsion, 1 acute myomectomy, and 2 acute hysterectomies were documented from Group 2 (NS differences).ConclusionThere was no significant difference in the effectiveness and in the number of minor and major complications between fibroids with <10 cm largest diameter compared to those >10 cm.

  12. T2-based temperature monitoring in abdominal fat during HIFU treatment of patients with uterine fibroids

    Science.gov (United States)

    Ozhinsky, Eugene; Kohi, Maureen; Ghanouni, Pejman; Rieke, Viola

    2017-03-01

    In this study, we have implemented T2-based monitoring of near-field heating in patients undergoing HIFU ablation of uterine fibroids using Insightec ExAblate system. In certain areas, near-field heating can reach 18°C and the tissue may experience sustained heating of more than 10°C for the period of 2 hours or more. This indicates a cumulative thermal dose that may cause necrosis. Our results show the feasibility and importance of measuring near-field heating in subcutaneous fat.

  13. Randomized Comparison of Uterine Artery Embolization (UAE) with Surgical Treatment in Patients with Symptomatic Uterine Fibroids (REST Trial): Subanalysis of 5-Year MRI Findings

    Energy Technology Data Exchange (ETDEWEB)

    Ananthakrishnan, Ganapathy, E-mail: ganapathy.ananthakrishnan@nhs.net [Gartnavel General Hospital, Department of Interventional Radiology (United Kingdom); Murray, Lilian, E-mail: Lilian.murray@glasgow.ac.uk [Vital Statistics (United Kingdom); Ritchie, Moira, E-mail: moira.ritchie@ggc.scot.nhs.uk [Gartnavel General Hospital, Department of Interventional Radiology (United Kingdom); Murray, Gordon, E-mail: Gordon.murray@ed.ac.uk [Centre for Population Health Sciences, University of Edinburgh, Department of Medical Statistics (United Kingdom); Bryden, Fiona, E-mail: Fiona.bryden@ggc.scot.nhs.uk [Stobhill Hospital (United Kingdom); Lassman, Sue, E-mail: sue.lassman@ggc.scot.nhs.uk [Gartnavel General Hospital, Department of Interventional Radiology (United Kingdom); Lumsden, Mary Ann, E-mail: Maryann.lumsden@glasgow.ac.uk [Room 12, Level 4, Walton Building, Department of Medical Education and Gynaecology, Reproductive and Maternal Medicine (United Kingdom); Moss, Jon G., E-mail: jon.moss@ggc.scot.nhs.uk [Gartnavel General Hospital, Department of Interventional Radiology (United Kingdom)

    2013-06-15

    Purpose. To report 5-year contrast-enhanced magnetic resonance imaging findings of the REST trial recruits who underwent either uterine artery embolization (UAE) or myomectomy. Methods. A total of 157 patients were randomized to UAE or surgery (hysterectomy or myomectomy). Ninety-nine patients who had UAE and eight patients who had myomectomy were analyzed. MRI scans at baseline, 6 months, and 5 years were independently interpreted by two radiologists. Dominant fibroid diameter, uterine volume, total fibroid infarction (complete 100 %, almost complete 90-99 %, partial <90 %), and new fibroid formation were the main parameters assessed and related to the need for reintervention. Results. In the UAE group, mean {+-} standard deviation uterine volume was 670 {+-} 503, 422 {+-} 353, and 292 {+-} 287 mL at baseline, 6 months, and 5 years, respectively. Mean dominant fibroid diameter was 7.6 {+-} 3.0, 5.8 {+-} 2.9, and 5 {+-} 2.9 cm at baseline, 6 months, and 5 years. Fibroid infarction at 6 months was complete in 35 % of women, almost complete in 29 %, and partial in 36 %. Need for reintervention was 19, 10, and 33 % in these groups, respectively (p = 0.123). No myomectomy cases had further intervention. At 5 years, the prevalence of new fibroid was 60 % in the myomectomy group and 7 % in the UAE group (p = 0.008). Conclusion. There is a further significant reduction in both uterine volume and dominant fibroid diameter between 6 months and 5 years after UAE. Complete fibroid infarction does not translate into total freedom from a subsequent reintervention. New fibroid formation is significantly higher after myomectomy.

  14. Telomerase expression abrogates rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells.

    Science.gov (United States)

    Suo, Guangli; Sadarangani, Anil; Tang, Wingchung; Cowan, Bryan D; Wang, Jean Y J

    2014-09-01

    Uterine fibroids are the most common solid tumors found in women of reproductive age. It has been reported that deregulation of the mammalian target of rapamycin (mTOR) pathway plays an important role in the etiology of leiomyoma. Here, we investigated the effect of rapamycin, an inhibitor of mTORC1, on the growth of primary fibroid smooth muscle cells (fSMCs) and human telomerase reverse transcriptase (hTERT)-transduced and immortalized fSMCs. With the primary fSMCs, a 24-hour treatment with rapamycin was sufficient to trigger a growth arrest that was not reversible upon drug removal. By contrast, the growth inhibitory effect of rapamycin on the hTERT-transduced fSMCs was readily reversible, as these cells resumed proliferation upon the withdrawal of the drug. These results suggest that rapamycin-induced irreversible growth arrest of fSMCs is dependent on the senescence barrier that is abrogated by the ectopic expression of telomerase.

  15. Racial/Ethnic Differences in Women's Experiences with Symptomatic Uterine Fibroids: a Qualitative Assessment.

    Science.gov (United States)

    Sengoba, Katherine S; Ghant, Marissa S; Okeigwe, Ijeoma; Mendoza, Gricelda; Marsh, Erica E

    2017-04-01

    The purpose of this study is to determine racial/ethnic differences in treatment experiences and expectations among women with fibroids. Sixty women with symptomatic uterine fibroids completed semi-structured interviews, demographic surveys, and a health literacy assessment. Participants were recruited from community-based organizations and health care organizations. Data from interviews were analyzed using a grounded theory approach. Three coders identified major themes and subthemes. The kappa (κ) among coders was 0.94. The mean age of participants was 43.0 ± 6.8 (mean ± SD). A total of 61.7 % of subjects were African-American (AAW), 25.0 % were non-Hispanic White (WW), 8.3 % were Hispanic (HW), and 5.0 % were Asian (ASW). When considering treatment options, AAW were more likely to want a permanent intervention. They were also more likely to demonstrate an aversion toward conventional treatments. Of the women who received a surgical intervention, AAW were also more likely to have had a difficult recovery and to be dissatisfied with their treatment. Finally, AAW disproportionately expressed concern regarding financial challenges. AAW have high treatment expectations, have more financial obstacles, and are less satisfied with their treatment outcomes than women of other racial/ethnic groups. Our findings suggest a need to create targeted patient interventions and education to ameliorate these disparities in experience.

  16. A Fibroid or Cancer? A Rare Case of Mixed Choriocarcinoma and Epithelioid Trophoblastic Tumour

    Directory of Open Access Journals (Sweden)

    Wan Yu Luk

    2013-01-01

    Full Text Available Background. Gestational trophoblastic disease (GTD is a rare complication of pregnancy which is characterised by abnormal growth of the trophoblasts at the placental site. It is categorised into benign and malignant forms, which include hydatidiform moles (HMs and gestational trophoblastic neoplasia (GTN, respectively. A mixed choriocarcinoma (CC and epithelioid trophoblastic tumour (ETT is an extremely rare subgroup of GTN, which is a highly curable but aggressive form of malignancy. Case. We report a case of mixed CC and ETT in a 41-year-old patient who presented with a 2-year history of menorrhagia and fibroid uterus in the absence of previous history of molar pregnancy. She had a 12-year interval between the antecedent pregnancy and presentation. She was treated with intensive regimen of adjuvant chemotherapy, etoposide, methotrexate, and actinomycin-D with etoposide and cisplatin (EMA-EP. She has remained disease free for more than 5 years. Conclusion. This case highlights the importance of considering GTN as one of the differential diagnoses value of β-HCG in patients presented with menorrhagia and growing fibroids.

  17. Central cervical fibroid with a typical Lantern on top of St. Paul's cathedral appearance

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    Ambarisha Bhandiwad

    2016-03-01

    Full Text Available Leiomyoma of the uterus in one of the common benign gynecological conditions and one of the rare locations of a fibroid is from the cervix with an incidence of upto 2%. We are reporting a case of a 46 year old patient who came with complaints of mass per abdomen and with a history of retention of urine twice in the past one and half months. Abdominal examination revealed a firm mass of 24 weeks size gravid uterus with restricted mobility arising from the pelvis and a speculum examination, showed a mass protruding through the vagina with all the walls ballooned out and it appeared as if a head of the baby was protruding out in second stage of labor. It was a 1.9kg central cervical fibroid with a typical "Lantern on top of St. Paul's cathedral" appearance which was operated without any complications. [Int J Reprod Contracept Obstet Gynecol 2016; 5(3.000: 924-926

  18. Uterine fibroids - therapy from the point of view of the gynaecologist; Uterusmyome - Behandlungsoptionen aus der Sicht des Gynaekologen

    Energy Technology Data Exchange (ETDEWEB)

    Middendorf, K. [Klinik und Poliklinik fuer Frauenheilkunde und Geburtshilfe, Grosshadern, Ludwig-Maximilians-Universitaet Muenchen (Germany); Klink und Poliklinik fuer Frauenheilkunde und Geburtshilfe, Grosshadern, Klinikum der Universitaet, Marchioninistr. 15, 81377, Muenchen (Germany); Burges, A.; Strauss, A.; Hepp, H. [Klinik und Poliklinik fuer Frauenheilkunde und Geburtshilfe, Grosshadern, Ludwig-Maximilians-Universitaet Muenchen (Germany)

    2003-08-01

    Uterine fibroids are the most common benign tumour affecting the female reproductive tract, 20% of all women older than 35 years are afflicted. Patients with fibroids tend to be asymptomatic, but fibroids may lead to meno-, metrorrhagia, hyper- and dysmenorrhoea and urination and defecation problems. If the fibroids do not cause any clinical symptoms and if there is no suspicion of a malignant tumor, there is no need for therapeutic intervention. Otherwise, besides the medical management with gestagenes and GnRH (gonadotropin-releasing hormone) analog, surgery represents the classical treatment. Hysterectomy is the common approach for women with completed family planning. For women who wish to conserve their fertility enucleation of the fibroids can be considered. These surgical procedures can be performed endoscopically or abdominally. Uterine artery embolisation, a radiological intervention, is less invasive and represents an interesting therapeutic alternative. (orig.) [German] Uterusmyome sind die haeufigste benigne Raumforderung im weiblichen Genitaltrakt, 20% aller Frauen ueber 35 Jahren sind davon betroffen. Meist sind sie asymptomatisch, Myome koennen jedoch auch zu Meno-, Metrorrhagien, Hyper- und Dysmenorrhoe sowie Beschwerden bei Miktion und Defaekation fuehren. Waehrend bei fehlender klinischer Symptomatik und insuspektem Befund kein therapeutischer Handlungsbedarf besteht, wird bei klinischer Symptomatik die Indikation zur therapeutischen Intervention gestellt. Neben der medikamentoesen Therapie mit Gestagenen und GnRH-(Gonadotropine-releasing-hormone-)Analoga ist die Operation das Verfahren der Wahl. Waehrend bei abgeschlossener Familienplanung eine Hysterektomie sinnvoll ist, wird bei Wunsch nach Organerhalt eine Myomenukleation durchgefuehrt, wobei endoskopische Verfahren und ein abdominaler Zugangsweg gewaehlt werden koennen. Die radiologisch interventionelle Myomembolisation stellt aufgrund ihrer geringeren Invasivitaet eine interessante

  19. Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5‐year results

    National Research Council Canada - National Science Library

    Moss, JG; Cooper, KG; Khaund, A; Murray, LS; Murray, GD; Wu, O; Craig, LE; Lumsden, MA

    2011-01-01

    .... Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5‐year results. BJOG 2011;118:936–944. Objective...

  20. MRI predictors of clinical success in MR-guided focused ultrasound (MRgFUS) treatments of uterine fibroids: results from a single centre

    Energy Technology Data Exchange (ETDEWEB)

    Mindjuk, Irene; Herzog, Peter; Matzko, Matthias [Helios-Amper Klinikum Dachau, Department of Diagnostic and Interventional Radiology, Helios-Amper Klinikum Dachau, Dachau, Dachau (Germany); Trumm, Christoph G.; Stahl, Robert [Klinikum der Ludwig-Maximilians-Universitaet Muenchen-Grosshadern, Muenchen, Department of Clinical Radiology, Muenchen (Germany)

    2015-05-01

    To assess the technical and clinical results of MRgFUS treatment and factors affecting clinical treatment success. A total of 252 women (mean age, 42.1 ± 6.9 years) with uterine fibroids underwent MRgFUS. All patients underwent MRI before treatment. Results were evaluated with respect to post-treatment nonperfused volume (NPV), symptom severity score (SSS), reintervention rate, pregnancy and safety data. NPV ratio was significantly higher in fibroids characterized by low signal intensity in contrast-enhanced T1-weighted fat saturated MR images and in fibroids distant from the spine (>3 cm). NPV ratio was lower in fibroids with septations, with subserosal component and in skin-distant fibroids (p < 0.001). NPV ratio was highly correlated with clinical success: NPV of more than 80 % resulted in clinical success in more than 80 % of patients. Reintervention rate was 12.7 % (mean follow-up time, 19.4 ± 8 months; range, 3-38). Expulsion of fibroids (21 %) was significantly correlated with a high clinical success rate. No severe adverse events were reported. Adequate patient selection and correct treatment techniques, based on the learning curve of this technology, combined with technical advances of the system, lead to higher clinical success rates with low complications rate, comparable to other uterine-sparing treatment options. (orig.)

  1. Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women

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    Zimmermann Anne

    2012-03-01

    Full Text Available Abstract Background In 2009 the Uterine Bleeding and Pain Women's Research Study (UBP-WRS was conducted interviewing 21,479 women across 8 countries in order to gain patient-based prevalence data on uterine pain and bleeding indications and investigate uterine symptoms and women's treatment experiences. This article shows relevant results of the study for the indication uterine fibroids providing data on self-reported prevalence, symptomatology and management of uterine fibroids. Methods 2,500 women (USA: 4,500 women in each country (Brazil, Canada, France, Germany, Italy, South Korea, the UK, the USA completed an online survey. Women included were in their reproductive age (age group 15-49 years; USA: 18-49 years and had ever experienced menstrual bleedings. Quotas were applied for age, region, level of education and household income of respondents. Variables have been analyzed descriptively and exploratory statistical tests have been performed. Results The self-reported prevalence of uterine fibroids ranged from 4.5% (UK to 9.8% (Italy, reaching 9.4% (UK to 17.8% (Italy in the age group of 40-49 years. Women with a diagnosis of uterine fibroids reported significantly more often about bleeding symptoms than women without a diagnosis: heavy bleedings (59.8% vs. 37.4%, prolonged bleedings (37.3% vs. 15.6%, bleeding between periods (33.3% vs. 13.5%, frequent periods (28.4% vs. 15.2%, irregular and predictable periods (36.3% vs. 23.9%. Furthermore women with diagnosed uterine fibroids reported significantly more often about the following pain symptoms: pressure on the bladder (32.6% vs. 15.0%, chronic pelvic pain (14.5% vs. 2.9%, painful sexual intercourse (23.5% vs. 9.1% and pain occurring mid-cycle, after and during menstrual bleeding (31.3%, 16.7%, 59.7%, vs. 17.1%, 6.4%, 52.0%. 53.7% of women reported that their symptoms had a negative impact on their life in the last 12 month, influencing their sexual life (42.9%, performance at work (27

  2. Stromal fibroblast activation and their potential association with uterine fibroids (Review)

    Science.gov (United States)

    ZHENG, LI-HUA; CAI, FENG-FENG; GE, ISABELL; BISKUP, EWELINA; CHENG, ZHONG-PING

    2014-01-01

    Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts in tumor microenvironments have emerged as an important target for cancer therapy. Repeated stimulation by infectious or non-infectious agents in the uterine tissues, including inflammation, mechanical forces or hypoxia, stimulate the resident fibroblasts to undergo specific activation and, thus, are significant in tumorigenesis. Furthermore, complex signaling pathways regulate the mechanisms of fibroblastic activation. The current review focuses on the molecular mechanisms of fibroblastic activation and the potential association with uterine leiomyoma pathogenesis, enabling an integrated pathogenic analysis for review of the therapeutic options. PMID:25013460

  3. Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MRgHIFU) for Treatment of Symptomatic Uterine Fibroids: An Economic Analysis

    Science.gov (United States)

    Babashov, V; Palimaka, S; Blackhouse, G; O'Reilly, D

    2015-01-01

    Background Uterine fibroids, or leiomyomas, are the most common benign tumours in women of childbearing age. Some women experience symptoms (e.g., heavy bleeding) that require aggressive forms of treatment such as uterine artery embolization (UAE), myomectomy, magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU), and even hysterectomy. It is important to note that hysterectomy is not appropriate for women who desire future childbearing. Objectives The objective of this analysis was to evaluate the cost-effectiveness and budgetary impact of implementing MRgHIFU as a treatment option for symptomatic uterine fibroids in premenopausal women for whom drugs have been ineffective. Review Methods We performed an original cost-effectiveness analysis to assess the long-term costs and effects of MRgHIFU compared with hysterectomy, myomectomy, and UAE as a strategy for treating symptomatic uterine fibroids in premenopausal women aged 40 to 51 years. We explored a number of scenarios, e.g., comparing MRgHIFU with uterine-preserving procedures only, considering MRgHIFU-eligible patients only, and eliminating UAE as a treatment option. In addition, we performed a one-year budget impact analysis, using data from Ontario administrative sources. Four scenarios were explored in the budgetary impact analysis: MRgHIFU funded at 2 centres MRgHIFU funded at 2 centres and replacing only uterine-preserving procedures MRgHIFU funded at 6 centres MRgHIFU funded at 6 centres and replacing only uterine-preserving procedures Analyses were conducted from the Ontario public payer perspective. Results The base case determined that the uterine artery embolization (UAE) treatment strategy was the cost-effective option at commonly accepted willingness-to-pay values. Compared with hysterectomy, UAE was calculated as having an incremental cost-effectiveness ratio (ICER) of $46,480 per quality-adjusted life-year (QALY) gained. The MRgHIFU strategy was extendedly dominated by a

  4. Patient-reported prevalence and symptomatic burden of uterine fibroids among women in the United States: findings from a cross-sectional survey analysis

    Directory of Open Access Journals (Sweden)

    Fuldeore MJ

    2017-06-01

    Full Text Available Mahesh J Fuldeore, Ahmed M Soliman Health Economics and Outcomes Research, AbbVie Inc., North Chicago, IL, US Purpose: To estimate the prevalence of women diagnosed with uterine fibroids and the associated symptom burden in the US.Patients and methods: Responses of women aged 18–54 years, who completed an online survey, were analyzed. Data were weighted based on age, education, race, geographic region, income, and propensity score to derive national estimates of the prevalence of women diagnosed with uterine fibroids and associated symptom burden. Weighted means and percentages were reported. Prevalence across age and ethnic groups was examined. Symptom burden among women with and without uterine fibroids was compared using weighted logistic regressions.Results: Of 59,411 respondents who met study inclusion criteria, 7.7% reported receiving a diagnosis of uterine fibroids. Of these, 5,670 women (1,402 in the uterine fibroid group and 4,268 in the control group were excluded from analysis because they had a hysterectomy. Among the non-hysterectomized study participants, 3,031 self-reported a diagnosis of uterine fibroids (prevalence: 5.8%, 95% confidence interval [CI]: 5.5%–6.1%; prevalence increased as women aged and was greatest in the 50–54 age group (11.4%; 95% CI: 10.4%–12.4%. In addition, prevalence was greater in black vs white women (9.8%; 95% CI: 8.7%–11.0% vs 5.4%; 95% CI: 5.1%–5.7%. A greater percentage of women with uterine fibroids (vs those without experienced severe heavy menstrual bleeding (16.7% vs 7.7%, severe constipation/bloating/diarrhea (7.7% vs 4.7%, severe passage of clots (6.7% vs 2.4%, severe spotting/bleeding between periods (1.7% vs 1.0%, and severe pelvic pressure (1.6% vs 0.6%. Among uterine fibroid patients with these typical uterine fibroid-related symptoms, 56.4%, 32.3%, 26.4%, 25.8%, and 20.4% reported heavy menstrual bleeding, passage of clots, spotting/bleeding between periods, constipation

  5. Outcome of unintended pregnancy after ultrasound-guided high-intensity focused ultrasound ablation of uterine fibroids.

    Science.gov (United States)

    Qin, Juan; Chen, Jin-Yun; Zhao, Wen-Peng; Hu, Liang; Chen, Wen-Zhi; Wang, Zhi-Biao

    2012-06-01

    To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation of uterine fibroids among women with unintentional pregnancy within 1 year of therapy. A retrospective analysis was conducted of 435 women who underwent USgHIFU therapy at Chongqing Medical University, China, between October 1, 2006, and October 1, 2009. Unplanned pregnancy was reported by 24 women within 1 year of USgHIFU ablation; 8 of these women had desired pregnancy before undergoing treatment. A total of 27 fibroids were detected, 24 of which were treated (mean volume 65.9±58.8 cm(3)). Pregnancy was continued by 7 women without any complications. One pregnant woman who had desired pregnancy before therapy underwent an induced abortion owing to concerns about the effects of USgHIFU on the fetus. Fourteen women without pregnancy intention before USgHIFU therapy chose to undergo induced abortion; 2 women experienced spontaneous abortion. No adhesion occurred after USgHIFU therapy. Furthermore, USgHIFU, labor, and abortion had no effect on subsequent menstruation or sexual activities. Pregnancy within 1 year after USgHIFU ablation of uterine fibroids appears safe; however, large scale studies are required to confirm these data. Copyright © 2012 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  6. Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications

    Science.gov (United States)

    Ciarmela, Pasquapina; Islam, Md. Soriful; Reis, Fernando M.; Gray, Peter C.; Bloise, Enrrico; Petraglia, Felice; Vale, Wylie; Castellucci, Mario

    2011-01-01

    BACKGROUND Growth factors are proteins secreted by a number of cell types that are capable of modulating cellular growth, proliferation and cellular differentiation. It is well accepted that uterine cellular events such as proliferation and differentiation are regulated by sex steroids and their actions in target tissues are mediated by local production of growth factors acting through paracrine and/or autocrine mechanisms. Myometrial mass is ultimately modified in pregnancy as well as in tumour conditions such as leiomyoma and leiomyosarcoma. Leiomyomas, also known as fibroids, are benign tumours of the uterus, considered to be one of the most frequent causes of infertility in reproductive years in women. METHODS For this review, we searched the database MEDLINE and Google Scholar for articles with content related to growth factors acting on myometrium; the findings are hereby reviewed and discussed. RESULTS Different growth factors such as epidermal growth factor (EGF), transforming growth factor-α (TGF-α), heparin-binding EGF (HB-EGF), acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF) and TGF-β perform actions in myometrium and in leiomyomas. In addition to these growth factors, activin and myostatin have been recently identified in myometrium and leiomyoma. CONCLUSIONS Growth factors play an important role in the mechanisms involved in myometrial patho-physiology. PMID:21788281

  7. Inflammatory fibroid polyp in the duodenum of a common marmoset (Callithrix jacchus).

    Science.gov (United States)

    Yokouchi, Yusuke; Imaoka, Masako; Sayama, Ayako; Jindo, Toshimasa; Sanbuissho, Atsushi

    2013-01-01

    A 32-month-old male common marmoset had a firm and white-colored mass in the duodenal wall. The cut surface was smooth and grayish white in color. Histologically, the mass consisted of a proliferation of spindle cells with an oval to spindle-shaped nucleus and scant eosinophilic cytoplasm in a loose myxoid or fibrotic background. Most of the lesion displayed no specific growth pattern whereas some of the cells concentrated around the vessels and created an onion-bulb structure. Additionally, marked inflammatory cellular infiltration, mainly eosinophils, was observed throughout the lesion. Immunohistochemically, the spindle cells were positive for vimentin, α-smooth muscle actin, fascin, and cyclin D1, and negative for S-100, factor VIII-related antigen, and c-kit. These histological and immunohistochemical features did not meet any differential diagnoses such as gastrointestinal stromal tumor, inflammatory myofibroblastic tumor, solitary fibrous tumor/hemangiopericytoma, smooth muscle tumor, schwannoma, and hemangiosarcoma. Collectively, the authors diagnosed the mass as a lesion that corresponded to an inflammatory fibroid polyp (IFP) in humans. IFP is defined as a mesenchymal proliferation composed of spindle stromal cells, small blood vessels, and inflammatory cells, particularly eosinophils, and is currently classified as a nonneoplastic lesion. To the best of our knowledge, this is the first case of spontaneous IFP in nonhuman primates.

  8. Tunable delivery of niflumic acid from resorbable embolization microspheres for uterine fibroid embolization.

    Science.gov (United States)

    Bédouet, Laurent; Moine, Laurence; Servais, Emeline; Beilvert, Anne; Labarre, Denis; Laurent, Alexandre

    2016-09-10

    Uterine arteries embolization (UAE) is a recent technique that aims, by means of particles injected percutaneously, to stifle fibroids (leiomyomas). This treatment is non-invasive, compared with uterine ablation, but generates pelvic pain for a few days. A strategy to reduce the post-embolization pain would be to use calibrated embolization microspheres preloaded with a non-steroidal inflammatory drug (NSAID). In this study, we first compared four drugs, all active at low concentration on cyclooxygenase-2, i.e. ketoprofen, sodium diclofenac, flurbiprofen and niflumic acid (NFA), for their capacity to be loaded on resorbable embolization microspheres (REM) 500-700μm. NFA had the highest capacity of loading (5mg/mL) on resorbable microspheres. Then, we evaluated in vitro the NFA release profiles from REM having various degradation times of one, two or five days. NFA release was biphasic, with an initial burst (about 60% of the loading) followed by a sustained release that correlated significantly to REM's hydrolysis (rho=0.761, pdegradation rate of REM to provide an antalgic effect for a few days after UAE.

  9. Abnormal excessive per vagina (PV) bleeding on Esmya-selective progesterone receptor modulator (SPRM) in a symptomatic patient with uterine fibroid.

    Science.gov (United States)

    Matytsina-Quinlan, Lyubov; Matytsina, Laura

    2015-05-14

    A woman in her late 40s presented with excessive per vagina (PV) bleeding and uterine fibroid. She reported excessive PV bleeding after starting Esmya; she was brought in by ambulance to the emergency department with profuse bleeding. Abnormal uterine bleeding (AUB) developed after selective progesterone receptor modulator (SPRM) administration in this symptomatic patient with uterine fibroid. The drug was withheld and surgical treatment considered. Progressive deterioration of PV bleeding after receiving SPRM led to an urgent laparoscopic total hysterectomy, which had to be postponed due to severe anaemia. Surgery took place regardless because the excessive bleeding continued. Histology revealed a 6 cm submucosal uterine fibroid (SMUF) and adenomyosis. Physicians prescribing SPRMs to stop PV bleeding should be aware of potential AUB, which could lead to urgent hysterectomy. The mechanism of action of SPRMs is not clearly understood. Awareness of the side effects of Esmya, such as AUB, must be kept in mind when administering SPRMs.

  10. Comparing the Use of Uterine Artery Embolization to Gonadotropin-Releasing Hormone Agonists in Shrinking Fibroid Size: A Pilot Study in Kazakhstan

    Directory of Open Access Journals (Sweden)

    Balkenzhe Imankulova

    2015-09-01

    Full Text Available Introduction: Uterine fibroids are the most common benign tumor in women in Kazakhstan. In the past two decades, endoscopic surgery has played an important role in the development of gynecologic surgery, particularly in the treatment of uterine fibroids. The goal of this paper is to evaluate whether uterine artery embolization (UAE or gonadotropin-releasing hormone agonists (GnRHa prior to myomectomy was more effective in decreasing fibroid size and improving surgical outcomes in a pilot study of women in Kazakhstan.Methods: This pilot investigation included 24 patients separated into 2 groups: medication group (pre-treatment with GnRHa – 13 patients and embolization group (pre-treatment with UAE – 11 patients. All patients had uterine fibroids, 3-10 cm in diameter, and were treated with myomectomy at the National Research Center for Maternal and Child Health, Astana, Kazakhstan. All patient data were obtained by a retrospective medical records review. Descriptive statistics were utilized to characterize participant demographics data. Independent t-tests were used to analyze continuous variables, and Chi-square and Fisher’s exact tests were used where appropriate for count data.Results: The group treated with GnRHa had an operating time of 40±10 minutes longer than the group treated with UAE, due to the peri-operative difficulties encountered by surgeons in detecting the layer between the myometrium and fibroid capsule. The group treated with UAE experienced better patient outcomes (less blood loss, less surgical time, and reduced use of anesthesia and was a technically easier surgery due to visible differences in uterine layers.Conclusions: Despite the fact that both treatments (GnRHa and UAE were effective for fibroid shrinking, embolization resulted in more optimal surgical time and improved patient outcomes. Results of this pilot study need to be confirmed in a randomized clinical trial, specifically focused on Kazakhstan and the

  11. Role of levonorgestrel releasing intra-uterine system in the treatment of menorrhagia due to dysfunctional uterine bleeding and fibroid uterus

    Directory of Open Access Journals (Sweden)

    Reena Gupta

    2014-06-01

    Full Text Available Background: This study was carried out to assess the clinical effectiveness of levonorgestrel releasing intrauterine device (LNG-IUS in the treatment of menorrhagia due to either Dysfunctional Uterine Bleeding (DUB or fibroid in Indian patients, and to assess patient satisfaction with this treatment modality. Methods: Sixty women with menorrhagia, 30 due to fibroid and 30 due to DUB, meeting inclusion criteria, received LNG-IUS and were prospectively followed up for 9 months with periodic clinical assessments and transvaginal ultrasounds. Patient satisfaction was assessed on a five-point scale. Results: One patient in DUB group was lost to follow-up. In DUB patients, the treatment failure rate was only 3.4% (1 out of 29 patients. The median PBAC score reduced by 95% at 9 months. Fibroid patients also had an equally impressive 97.7% reduction of PBAC score at 9 months, although the failure rate was higher (23.3%; 7 out of 30. Majority of patients were either and lsquo;very satisfied' or and lsquo;satisfied' with the treatment, although this percentage was more in DUB (82.8% than in the fibroid group (66.7%. Haemoglobin and serum ferritin levels significantly increased in both groups. No major side effect was noted. Conclusions: LNG-IUS is an excellent treatment modality for patients of DUB, with good patient satisfaction. It is also a useful treatment option in non-submucosal small fibroids for the symptoms of menorrhagia, can reduce uterine volume and can help avoid hysterectomy, but there is no effect on fibroid volume. Majority of patients are satisfied, although satisfaction rates are less than in DUB patients. [Int J Reprod Contracept Obstet Gynecol 2014; 3(3.000: 671-677

  12. DNA microarray data integration by ortholog gene analysis reveals potential molecular mechanisms of estrogen-dependent growth of human uterine fibroids

    Directory of Open Access Journals (Sweden)

    Shou Jianyong

    2007-04-01

    Full Text Available Abstract Background Uterine fibroids or leiomyoma are a common benign smooth muscle tumor. The tumor growth is well known to be estrogen-dependent. However, the molecular mechanisms of its estrogen-dependency is not well understood. Methods Differentially expressed genes in human uterine fibroids were either retrieved from published papers or from our own statistical analysis of downloaded array data. Probes for the same genes on different Affymetrix chips were mapped based on probe comparison information provided by Affymetrix. Genes identified by two or three array studies were submitted for ortholog analysis. Human and rat ortholog genes were identified by using ortholog gene databases, HomoloGene and TOGA and were confirmed by synteny analysis with MultiContigView tool in the Ensembl genome browser. Results By integrated analysis of three recently published DNA microarray studies with human tissue, thirty-eight genes were found to be differentially expressed in the same direction in fibroid compared to adjacent uterine myometrium by at least two research groups. Among these genes, twelve with rat orthologs were identified as estrogen-regulated from our array study investigating uterine expression in ovariectomized rats treated with estrogen. Functional and pathway analyses of the twelve genes suggested multiple molecular mechanisms for estrogen-dependent cell survival and tumor growth. Firstly, estrogen increased expression of the anti-apoptotic PCP4 gene and suppressed the expression of growth inhibitory receptors PTGER3 and TGFBR2. Secondly, estrogen may antagonize PPARγ signaling, thought to inhibit fibroid growth and survival, at two points in the PPAR pathway: 1 through increased ANXA1 gene expression which can inhibit phospholipase A2 activity and in turn decrease arachidonic acid synthesis, and 2 by decreasing L-PGDS expression which would reduce synthesis of PGJ2, an endogenous ligand for PPARγ. Lastly, estrogen affects retinoic

  13. Effect of biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging, on ultrasound-guided high-intensity focused ultrasound ablation.

    Science.gov (United States)

    Zhao, Wen-Peng; Chen, Jin-Yun; Chen, Wen-Zhi

    2015-02-01

    The aims of this study were to assess the effects of the biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging (MRI), on ultrasound-guided high-intensity focused ultrasound (USgHIFU) ablation. Thirty-five patients with 39 symptomatic uterine fibroids who underwent myomectomy or hysterectomy were enrolled. Before surgery, the uterine fibroids were subdivided into hypo-intense, iso-intense, heterogeneous hyper-intense and homogeneous hyper-intense categories based on signal intensity on T2-weighted MRI. Tissue density and moisture content were determined in post-operative samples and normal uterine tissue, the isolated uterine fibroids were subjected to USgHIFU, and the extent of ablation was measured using triphenyltetrazolium chloride. Hematoxylin and eosin staining and sirius red staining were undertaken to investigate the organizational structure of the uterine fibroids. Estrogen and progesterone receptor expression was assayed via immunohistochemical staining. The mean diameter of uterine fibroids was 6.9 ± 2.8 cm. For all uterine fibroids, the average density and moisture content were 10.7 ± 0.7 mg/mL and 75.7 ± 2.4%, respectively; and for the homogeneous hyper-intense fibroids, 10.3 ± 0.5 mg/mL and 76.6 ± 2.3%. The latter subgroup had lower density and higher moisture content compared with the other subgroups. After USgHIFU treatment, the extent of ablation of the hyper-intense fibroids was 102.7 ± 42.1 mm(2), which was significantly less than those of the hypo-intense and heterogeneous hyper-intense fibroids. Hematoxylin and eosin staining and sirius red staining revealed that the homogeneous hyper-intense fibroids had sparse collagen fibers and abundant cells. Immunohistochemistry results revealed that estrogen and progesterone receptors were highly expressed in the homogeneous hyper-intense fibroids. This study revealed that lower density, higher moisture content, sparse collagen

  14. Midterm Results after Uterine Artery Embolization Versus MR-Guided High-Intensity Focused Ultrasound Treatment for Symptomatic Uterine Fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Froeling, V., E-mail: vera.froeling@charite.de; Meckelburg, K., E-mail: katrin.meckelburg@charite.de; Scheurig-Muenkler, C., E-mail: christian.scheurig-muenkler@charite.de; Schreiter, N. F., E-mail: nils.schreiter@charite.de; Kamp, J., E-mail: julia.kamp@charite.de; Maurer, M. H., E-mail: martin.maurer@charite.de; Beck, A., E-mail: alexander.beck@charite.de; Hamm, B., E-mail: bernd.hamm@charite.de; Kroencke, T. J., E-mail: Thomas.kroencke@charite.de [Charite-Universitaetsmedizin Berlin, Department of Radiology (Germany)

    2013-12-15

    Purpose: To compare the rate of reintervention and midterm changes in symptom severity (SS) and Total health-related quality of life (HRQoL) scores after uterine artery embolization (UAE) and magnetic resonance-guided high-intensity focused ultrasound (MR-g HIFU) for symptomatic uterine fibroids. Methods: Eighty women (median age 38.3 years), equally eligible for MR-g HIFU and UAE who underwent one of both treatments between 2002 and 2009 at our institution, were included. The primary end point of the study was defined as the rate of reintervention after both therapies. The secondary outcome was defined as changes in SS and Total HRQoL scores after treatment. SS and Total HRQoL scores before treatment and at midterm follow-up (median 13.3 months) were assessed by the uterine fibroid symptom and quality-of-life questionnaire (UFS-QoL) and compared. Results: The rate of reintervention was significantly lower after UAE than after MR-g HIFU (p = 0.002). After both treatments, SS and Total HRQoL scores improved significantly from baseline to follow-up (UAE: p < 0.001, p < 0.001; MR-g HIFU: p = 0.002, p < 0.001). Total HRQoL scores were significantly higher after UAE than after MR-g HIFU (p = 0.032). Changes in the SS scores did not differ significantly for both treatments (p = 0.061). Conclusion: UAE and MR-g HIFU significantly improved the health-related quality of life of women with symptomatic uterine fibroids. After UAE, the change in Total HRQoL score improvement was significantly better, and a significantly lower rate of reintervention was observed.

  15. A novel method to aid in the visualisation and treatment of uterine fibroids with MRgFUS in patients with abdominal scars

    Energy Technology Data Exchange (ETDEWEB)

    Zaher, Summia, E-mail: summia.zaher@imperial.nhs.uk [Imperial College/St Mary' s Hospital, Praed Street, London W2 1NY (United Kingdom); Gedroyc, Wladyslaw, E-mail: w.gedroyc@imperial.ac.uk [Imperial College/St Mary' s Hospital, Praed Street, London W2 1NY (United Kingdom); Lyons, Deidre, E-mail: deidre.lyons@imperial.nhs.uk [Imperial College/St Mary' s Hospital, Praed Street, London W2 1NY (United Kingdom); Regan, Lesley, E-mail: l.regan@imperial.ac.uk [Imperial College/St Mary' s Hospital, Praed Street, London W2 1NY (United Kingdom)

    2010-11-15

    The purpose of this research was to identify a method for performing Magnetic Resonance Imaging Guided Focused Ultrasound Surgery (MRgFUS) of symptomatic uterine fibroids in patients with abdominal scars, by visualisation of these scars on MR images. 25 patients who presented with treatable symptomatic uterine fibroids and having transverse abdominal scars were treated with MRgFUS. A solution containing MRI contrast paramagnetic iron oxide particles was used to demark the skin surface scar tissue on the treatment planning MR images. During treatment, the focused ultrasound energy was steered around the scar based on its enhanced visual location. After the treatment, contrast enhanced MR images were acquired for immediate results evaluation. Adverse events and fibroid related symptoms were captured during the 6-months follow up period. All the women were treated with no complications. No episodes of skin burns, ulceration or skin redness were reported. The post-treatment contrast-enhanced MR images showed an average fibroid non-perfused volume ratio of 64%. At their 6-month follow-up, 92% of the patients reported a clinical improvement. Using paramagnetic iron oxide solution to highlight transverse abdominal scars helps in their identification on MR images, thereby enabling the operator to avoid scars and facilitating the treatment of women who were previously excluded.

  16. Volumetric ablation of uterine fibroids using Sonalleve high-intensity focused ultrasound in a 3 Tesla scanner--first clinical assessment.

    Science.gov (United States)

    Dorenberg, Eric J; Courivaud, Frédéric; Ring, Eva; Hald, Kirsten; Jakobsen, Jarl Å; Fosse, Erik; Hol, Per Kristian

    2013-04-01

    The purpose of this study was to evaluate the feasibility and safety of the Sonalleve high-intensity focused ultrasound (HIFU; Philips Healthcare, Vantaa, Finland) system in ablating uterine fibroids in a 3T magnet. Seven women were included in this study. Treatment was performed according to the manufacturer's recommendation. Technical data describing the HIFU procedures were collected. On MR images at baseline, immediately and 30 days after ablation, we evaluated the volumes of the uterus, the dominant fibroid and the ablation zone. The Uterine Fibroid Symptom and Quality of Life (UFS-QOL) questionnaire was used to assess potential clinical response. The procedure was technically feasible in all patients. The median number of sonications performed during each procedure was 20 (range 2-27) per patient, the maximum temperature in all sonication cells was about 68°C. The median procedure time was 156 minutes (range 95-164). The non-perfused volume after treatment ranged from 1 to 27 ml and was unchanged or decreased in all but one patient at 30 days follow-up. There were no major adverse events. In our 3T magnet the system was able to heat tissue and induce areas of non-enhancement within uterine fibroids without major complications. Clinical benefit remains to be proven.

  17. Fracture of the Femur of A Newborn after Cesarean Section for Breech Presentation and Fibroid Uterus :A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Ibrahima Farikou

    2014-01-01

    Full Text Available Introduction: The practice of cesarean section is known to decrease the occurrence of long bone fractures. We present here an unusual diaphyseal fracture of the femur of a newborn after cesarean section, the only case observed in our 14 years of practice. Case Report: The patient was a 3.4-kg female child born at 38 weeks of gestation. The mother was a primipara and aged 39 years. Ultrasound examination at 20th week revealed intrauterine fibroids with a breech presentation. Therefore, elective cesarean section was indicated. There was no apparent bone disorder that could predispose to sustain femur fracture. The fracture was treated successfully with a bilateral spica cast. The cesarean section was indicated in an aged primipara, bearer of uterine fibroids, and breech presentation. She had a good general health status, but her bone density was unknown since this examination is not routinely performed in our clinical settings in Africa. Conclusion: Elderly age, primipara status, presence of uterine fibroids, and breech presentation are usual indications for cesarean section. However, there are not many reports on femur fracture after cesarean section. Our present case suggests that despite the latest advances in delivery techniques, cesarean section for breech presentation predisposes the neonate to femoral fractures. Keywords: Femur fracture; Cesarean section; Fibroid; Breech presentation; Africa.

  18. Information-seeking behavior of women in their path to an innovative alternate treatment for symptomatic uterine fibroids.

    Science.gov (United States)

    Ankem, Kalyani

    2007-04-01

    The purpose of the study was to discover how women found out about uterine fibroid embolization (UFE) for the treatment of symptomatic uterine fibroids. The study retrospectively tracked women from the beginning of their illnesses and analyzed their information-seeking behaviors. Twenty-eight women who had the procedure at the Detroit Medical Center were interviewed using a standard script. Median values and frequencies were calculated to represent information needs, information sources, and perceived helpfulness. Spearman correlations were calculated to find relationships between demographics and information needs. Although the women expressed a great need for almost all types of information (median = 5), those with higher levels of education indicated a greater need to know the reasons that their doctors had for suggesting treatments (r = 0.55). The gathered frequencies indicated that friends, magazines, television, and the Internet were important information sources. A preliminary model of information seeking showed that while friends, magazines, and television made several of the women aware of the new procedure, the Internet was heavily utilized for learning about treatment options. Health sciences librarians may inform women about their health and treatment options by guiding women to easily readable, authoritative, and reliable information sources, including Web information sites.

  19. Quality and safety control of tumor-shrinking decoction (TSD): A Chinese herbal preparation for the treatment of uterine fibroids.

    Science.gov (United States)

    Chen, Xiao-Xin; Lin, Wai Ling; Yeung, Wing Fai; Song, Tian-He; Lao, Li-Xing; Zhang, Yan-Bo; Meng, Wei

    2017-01-01

    Reproducible efficacy assessments of Chinese herbal medicines are largely based on well-established quality control procedures. This study presents a comprehensive quality control procedure for tumor-shrinking decoction (TSD), a 15-herb preparation under study as a potential therapy for uterine fibroids. Morphological, microscopic, and physicochemical authentications were first carried out on individual herbal medicines composing TSD. Contaminant tests on TSD for the presence of heavy metals and pesticide residues were performed by atomic absorption spectrophotometry and gas chromatography-mass spectrometry analysis. Furthermore, batch-to-batch quality monitoring of the decoction was investigated via ultra-performance liquid chromatography (UPLC) and high-performance liquid chromatography (HPLC). An aqueous extract of the herbal medicines was prepared and formulated into TSD. The tested contaminants were within the maximum permitted levels of the Hong Kong government in proprietary Chinese medicines. UPLC and HPLC fingerprints for quality tracking on TSD were established. The decoction was quantitatively standardized by UPLC and HPLC, respectively, with five and three chemical compounds serving as references. Collectively, the procedure established in this study will not only serve as a fundamental basis for the investigation and development of TSD as a novel therapy for uterine fibroids, but also as a protocol for studying other polycomponent herbal preparations. © 2015 International Union of Biochemistry and Molecular Biology, Inc.

  20. Incidence and clinical characteristics of unexpected uterine sarcoma after hysterectomy and myomectomy for uterine fibroids: a retrospective study of 10,248 cases

    Directory of Open Access Journals (Sweden)

    Zhao WC

    2015-10-01

    Full Text Available Wan-Cheng Zhao,1 Fang-Fang Bi,1 Da Li,2 Qing Yang11Department of Obstetrics and Gynecology, 2Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaBackground: Uterine fibroids often require a hysterectomy or myomectomy via laparotomy or laparoscopy. Morcellation is often necessary to perform a laparoscopic surgery. The objective of this study is to determine the incidence of unexpected uterine sarcomas (UUSs after hysterectomy and myomectomy for uterine fibroids and to reduce the occurrence and avoid the morcellation of UUSs by analyzing their characteristics.Methods: Women who had a hysterectomy or myomectomy for uterine fibroids in Shengjing Hospital of China Medical University between November 2008 and November 2014 were selected for the study, and their clinical characteristics were analyzed.Results: During the period, 48 UUSs were found in 10,248 cases, and the overall incidence was 0.47%. There was no statistical difference (P=0.449 regarding the incidence (0.50% vs 0.33% between 42 UUSs in 8,456 cases undergoing laparotomy and six UUSs in 1,792 cases undergoing laparoscopy. Most of the UUSs were stage I (89.58%, which occurred more commonly (56.25% in women aged 40–49. Abnormal uterine bleeding (39.58% was the main clinical manifestation. Rapidly growing pelvic masses (12.5%, rich blood flow signals (18.75%, and degeneration of uterine fibroids (18.75% prompted by ultrasonography may suggest the possibility of UUSs. The margins of most UUSs (93.75% were regular, which may cause UUSs to be misdiagnosed as uterine fibroids. Fifteen cases underwent magnetic resonance imaging examinations. Approximately 73.33% showed heterogeneous and hypointense signal intensity on T1-weighted images, and 80% showed intermediate-to-high signal intensity on T2-weighted images, with necrosis and hemorrhage in 40% of cases. After contrast administration, 80% presented early heterogeneous

  1. Feasibility of magnetic resonance imaging-guided high intensity focused ultrasound therapy for ablating uterine fibroids in patients with bowel lies anterior to uterus

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Lian; Chen Wenzhi [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Liu Yinjiang; Hu Xiao [National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Zhou Kun [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Chen Li [National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Peng Song; Zhu Hui [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Zou Huiling [National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Bai Jin [Institute of Ultrasound Engineering in Medicine of Chongqing University of Medical Sciences, Chongqing 400016 (China); Wang Zhibiao [Clinical Center for Tumour Therapy of 2nd Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); National Engineering Research Center of Ultrasound Medicine, Chongqing 400010 (China); Institute of Ultrasound Engineering in Medicine of Chongqing University of Medical Sciences, Chongqing 400016 (China)], E-mail: wangzhibiao@haifu.com.cn

    2010-02-15

    Purpose: To prospectively evaluate the feasibility of magnetic resonance (MR) imaging-guided high intensity focused ultrasound (HIFU) therapeutic ablation of uterine fibroids in patients with bowel lies anterior to uterus. Materials and methods: Twenty-one patients with 23 uterine fibroids underwent MR imaging-guided high intensity focused ultrasound treatment, with a mean age of 39.4 {+-} 6.9 (20-49) years, with fibroids average measuring 6.0 {+-} 1.6 (range, 2.9-9.5) cm in diameter. After being compressed with a degassed water balloon on abdominal wall, MR imaging-guided high intensity focused ultrasound treatment was performed under conscious sedation by using fentanyl and midazolam. This procedure was performed by a Haifu JM focused ultrasound tumour therapeutic system (JM2.5C, Chongqing Haifu Technology Co., Ltd., China), in combination with a 1.5-Tesla MRI system (Symphony, Siemens, Germany), which provides real-time guidance and control. Contrast-enhanced MR imaging was performed to evaluate the efficacy of thermal ablation immediately and 3 months after HIFU treatment. The treatment time and adverse events were recorded. Results: The mean fibroid volume was 97.0 {+-} 78.3 (range, 12.7-318.3) cm{sup 3}. According to the treatment plan, an average 75.0 {+-} 11.4% (range, 37.8-92.4%) of the fibroid volume was treated. The mean fibroid volume immediately after HIFU was 109.7 {+-} 93.1 (range, 11.9-389.6) cm{sup 3}, slightly enlarged because of edema. The average non-perfused volume was 83.3 {+-} 71.7 (range, 7.7-282.9) cm{sup 3}, the average fractional ablation, which was defined as non-perfused volume divided by the fibroid volume immediately after HIFU treatment, was 76.9 {+-} 18.7% (range, 21.0-97.0%). There were no statistically significant differences between the treatment volume and the non-perfused volume. Follow-up magnetic resonance imaging (MRI) at 3 months obtained in 12 patients, the fibroid volume decreased by 31.4 {+-} 29.3% (range, -1.9 to 60

  2. Role of 3-Dimensional Sonography in the Assessment of Submucous Fibroids: A Pilot Study.

    Science.gov (United States)

    Keizer, Alieke L; Nieuwenhuis, Lotte L; Twisk, Jos W R; Huirne, Judith A F; Hehenkamp, Wouter J K; Brölmann, Hans A M

    2017-08-04

    To investigate the accuracy and reliability of 3-dimensional (3D) transvaginal sonography in classifying submucous fibroids using the International Federation of Gynecology and Obstetrics PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, and not yet classified) classification and protrusion (percent) compared to 2-dimensional (2D) transvaginal sonography, 2D saline infusion sonography, and 3D saline infusion sonography, using hysteroscopy as a reference test. A prospective cohort pilot study was performed among 14 consecutive patients undergoing hysteroscopic surgery, preceded by routine sonography (2D transvaginal sonography, 2D saline infusion sonography, 3D transvaginal sonography, and 3D saline infusion sonography). The intraclass correlation coefficient (ICC) for 2D transvaginal sonography versus hysteroscopy was 0.69 (95% confidence interval [CI], 0.06, 0.90) compared to 0.94 (95% CI, 0.83, 0.98) for 2D saline infusion sonography. The ICCs for 3D transvaginal sonography versus hysteroscopy were 0.69 (95% CI, 0.03, 0.90 [investigator A]) and 0.55 (95% CI, -0.48, 0.86 [investigator B]). The ICCs for 3D saline infusion sonography versus hysteroscopy were 0.94 (95% CI, 0.81, 0.98 [investigator A]) and 0.87 (95% CI, 0.60, 0.96 [investigator B]). Interobserver agreement of 3D transvaginal sonography was 0.81 (95% CI, 0.43, 0.94) compared to 0.86 (95% CI, 0.56, 0.96) for 3D saline infusion sonography. In these preliminary data, 3D transvaginal sonography was not as accurate as 2D or 3D saline infusion sonography and was not more accurate than 2D transvaginal sonography. There was moderate interobserver agreement for 3D transvaginal sonography. There might be room for improvement, as 3D transvaginal sonography is more accurate when endometrial thickness increases. Further study is warranted to evaluate in which patients saline infusion sonography eventually can be obviated. © 2017 by

  3. Incorporating ulipristal acetate in the care of symptomatic uterine fibroids: a Canadian cost-utility analysis of pharmacotherapy management

    Directory of Open Access Journals (Sweden)

    Tsoi B

    2015-04-01

    Full Text Available Bernice Tsoi,1,2 Gord Blackhouse,1,2 Simon Ferrazzi,3 Clare J Reade,4 Innie Chen,5,6 Ron Goeree1,2,7 1Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; 2Programs for Assessment of Technology in Health (PATH Research Institute, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada; 3Independent Consultant, Oakville, ON, Canada; 4Division of Gynecologic Oncology, University of Toronto, Toronto, ON, Canada; 5Department of Obstetrics and Gynaecology, University of Ottawa, 6Ottawa Hospital Research Institute, Ottawa, ON, Canada; 7Centre for Evaluation of Medicines (CEM, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada Objective: To present a Canadian economic evaluation on the cost-utility of ulipristal acetate (5 mg orally daily compared to leuprolide acetate (3.75 mg intramuscular monthly in the treatment of moderate-to-severe symptoms of uterine fibroids in women eligible for surgery. Methods: A probabilistic decision tree was constructed to model the pre-operative pharmacological management of uterine fibroids under the primary perspective of the Ontario public payer. The model parameterized data from clinical trials, observational studies, and public costing databases. The outcome measure was the incremental cost-utility ratio. Uncertainty in the model was explored through sensitivity and scenario analyses. Results: Ulipristal was associated with faster control of excessive menstrual bleeding, fewer symptoms of hot flashes and lower health care resource consumption. The ulipristal strategy dominated leuprolide as it provided patients with more quality-adjusted life years (0.177 versus 0.165 at a lower cost ($1,273 versus $1,366. Across a range of sensitivity analyses, the results remained robust except to the dose of the comparator drug. If leuprolide was administered at 11.25 mg, once every 3 months, the expected cost for the leuprolide strategy would decline and the associated incremental

  4. Dynamic enhanced computed tomography imaging findings of an inflammatory fibroid polyp with massive fibrosis in the stomach

    Science.gov (United States)

    Shim, Eun Jung; Ahn, Sung Eun; Lee, Dong Ho; Park, Seong Jin; Kim, Youn Wha

    2017-01-01

    Inflammatory fibroid polyp (IFP) is a rare benign lesion of the gastrointestinal tract. We report a case of computed tomography (CT) imaging finding of a gastric IFP with massive fibrosis. CT scans showed thickening of submucosal layer with overlying mucosal hyperenhancement in the gastric antrum. The submucosal layer showed increased enhancement on delayed phase imaging. An antrectomy with gastroduodenostomy was performed because gastric cancer was suspected, particularly signet ring cell carcinoma. The histopathological diagnosis was an IFP with massive fibrosis. The authors suggest that when the submucosal layer of the gastric wall is markedly thickened with delayed enhancement and preservation of the mucosal layer, an IFP with massive fibrosis should be considered in the differential diagnosis. PMID:28373777

  5. Intususcepción intestinal debido a un pólipo fibroide inflamatorio (tumor de vanek

    Directory of Open Access Journals (Sweden)

    Pedro Madriz de Haan

    2014-03-01

    Full Text Available Presentamos el caso de un hombre de 58 años, quien consultó por cuadro de dolor abdominal de tres meses de evolución. En un periodo de 8 días previo a dicha consulta el dolor se intensificó y asoció vómitos incontables de contenido biliar y fecaloides. Se manejó como un abdomen agudo y se le realizó una laparotomía exploratoria, en la cual se evidenció una masa en yeyuno, con obstrucción distal completa e intosuscepción. El análisis histopatológico de la lesión confirmó un pólipo fibroide inflamatorio (Tumor de Vanek del yeyuno. En este artículo se discuten las características clínicas e histopatológicas.

  6. Endometrial Expression of Homeobox Genes and Cell Adhesion Molecules in Infertile Women With Intramural Fibroids During Window of Implantation.

    Science.gov (United States)

    Makker, Annu; Goel, Madhu Mati; Nigam, Dipti; Bhatia, Vikram; Mahdi, Abbas Ali; Das, Vinita; Pandey, Amita

    2017-03-01

    This study was designed to examine the expression and cellular distribution of homeobox ( HOX) genes ( HOXA10 and HOXA11) and cell adhesion molecules (E-cadherin, N-cadherin, and β-catenin) during the window of implantation in infertile women with noncavity-distorting intramural (IM) fibroids (n = 18) and in fertile controls (n = 12). Quantitative real-time polymerase chain reaction and immunohistochemistry were used to evaluate the messenger RNA (mRNA) levels and protein expression, respectively. When compared to fertile controls, reduced HOXA10 and HOXA11 transcript and protein levels were observed in infertile women. However, changes only in the expression of HOXA10 mRNA (-1.72-fold; P = .03) and stromal protein ( P = .001) were statistically significant. Significantly lower E-cadherin mRNA (-10.97-fold; P = .02) and protein levels were seen in infertile patients. E-cadherin immunostaining was significantly reduced both in the luminal ( P = .048) and in the glandular ( P = .014) epithelium of endometrium from infertile patients when compared to controls. No significant change was observed either in the mRNA levels or in the immunoexpression of N-cadherin and β-catenin. However, a trend toward lower N-cadherin expression in the luminal epithelium ( P = .054) and decreased β-catenin expression in the glandular epithelium ( P = .070) was observed in infertile patients. The present findings suggest that altered endometrial HOXA10 and E-cadherin mRNA and protein expression observed in infertile women with IM fibroids during the mid-secretory phase might impair endometrial receptivity leading to infertility in these patients.

  7. Interest of uterine artery embolization with gelatin sponge particles prior to myomectomy for large and/or multiple fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Butori, Noemie [Department of Vascular and Interventional Radiology, University of Dijon School of Medicine, Bocage Teaching Hospital, 2 bd du Marechal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex (France); Tixier, Herve; Filipuzzi, Laurence; Mutamba, William [Department of Gynecology and Obstetrics, University of Dijon School of Medicine, Bocage Teaching Hospital, 2 bd du Marechal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex (France); Guiu, Boris; Cercueil, Jean-Pierre [Department of Vascular and Interventional Radiology, University of Dijon School of Medicine, Bocage Teaching Hospital, 2 bd du Marechal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex (France); Douvier, Serge; Sagot, Paul [Department of Gynecology and Obstetrics, University of Dijon School of Medicine, Bocage Teaching Hospital, 2 bd du Marechal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex (France); Krause, Denis [Department of Vascular and Interventional Radiology, University of Dijon School of Medicine, Bocage Teaching Hospital, 2 bd du Marechal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex (France); Loffroy, Romaric, E-mail: romaric.loffroy@chu-dijon.fr [Department of Vascular and Interventional Radiology, University of Dijon School of Medicine, Bocage Teaching Hospital, 2 bd du Marechal de Lattre de Tassigny, BP 77908, 21079 Dijon Cedex (France)

    2011-07-15

    Purpose: To evaluate the efficacy of pre-myomectomy uterine artery embolization with gelatin sponge particles to reduce operative blood loss and facilitate removal of fibroids. Materials and methods: This retrospective study included 33 women (mean age, 36 years; range, 24-45 years), of whom at least 18 wished to preserve fertility. They presented with at least one large myoma (mean diameter, 90 mm; range, 50-150 mm) and had undergone preoperative uterine artery embolization with resorbable gelatin sponge by unilateral femoral approach between December 2001 and November 2008. Clinical, radiological and surgical data were available for all patients. Mean haemoglobin levels before and after surgery were compared with Student's t-test. Results: No complication or technical failure of embolization occurred. The myomectomies were performed during laparotomy (25 cases) or laparoscopy (8 cases). Dissection of fibroids was easier (mean, 3 per patient; range, 1-11), with a mean operating time of 108 {+-} 50 min (range, 30-260 min). Bloodless surgery was the rule with a mean estimated peroperative blood loss of 147 {+-} 249 mL (range, 0-800 mL). Mean pre-(12.9 {+-} 1.3 g/dL) and post-therapeutic (11.4 {+-} 1.2 g/dL) haemoglobin levels were not statistically different (p > 0.05). There was no need for blood transfusion. None of the patients required hysterectomy. The mean duration of hospital stay was 7.5 {+-} 1.3 days (range, 3-12 days). Conclusion: Preoperative uterine artery embolization is effective in reducing intraoperative blood loss and improves the chances of performing conservative surgery. It should be considered a useful adjunct to myomectomy in women at high hemorrhagic risk or who refuse blood transfusion.

  8. 影响中国A股市场中长期若干因素分析和预见%Analysis of the Mid-long Term Influential Factors on China's A-share Market

    Institute of Scientific and Technical Information of China (English)

    李兴汉; 刘若非

    2002-01-01

    鉴于国内国际经济形势的变化,我国今后很有可能启动积极的财政政策;投资基金的超常规发展,市场将更加注重理性投资和价值发现,对投资基金的期望值不要过高;降佣对券商是一次生存的考验,它必须通过差异化服务去争取更多的客户;中国入世对上市公司的影响值得长期关注和研究;中国A股市场的扩容压力仍然很大.

  9. Oil alternative strategies and mid-long term development goals of bio-energy%石油替代战略与生物质能源中长期发展目标

    Institute of Scientific and Technical Information of China (English)

    李十中

    2011-01-01

    The guarantee feedstock resources for developing bio-energy in China were introduced in this paper, including land resources, forest resources, straw resource, agricultural residual and organic waste. The significance and developing prospect of biomass energy were presented from a strategic perspective. Main bio-energy products and biomass conversion techniques were reviewed, such as fuel ethanol, biodiesel, biogas and bio-pelletes etc. The goals of developing bio-energy at different stages in our nation from now to 2050 were introduced, and some feasible advices were given from the views of policy, technology and environmental protection.%以我国发展生物质能源的资源保障为基础,包括土地资源、林地资源、秸秆资源、农林剩余物,以及有机废弃物资源等,分析了我国生物质资源的地位作用和发展前景,综述了燃料乙醇、生物柴油、沼气等主要生物能源产品及其转化技术,介绍了我国对各种生物质能源产品从目前到2050年分阶段的发展目标,并且从政策、技术、环保等多个角度,提出了一些发展生物质能源的建议.

  10. Sketch of mid-long term (2030, 2050) development strategy study of hydropower in China%水电中长期(2030、2050)发展战略研究

    Institute of Scientific and Technical Information of China (English)

    晏志勇; 钱钢粮

    2011-01-01

    以我国水力资源蕴藏量及分布特点为基础,分析我国水力资源的地位和作用,回顾水力资源开发的历程与现状,对比分析我国与国外部分国家水电开发的差异,提出我国水电开发的战略思路、目标及重点,并提出未来水电开发有关措施和建议.%Based on the hydropower potential and distribution features, analyze the status and role of hydropower in China, review the history of hydropower development and current situation, contrast and analyze the differences of hydropower development in China and some other overseas countries, present strategy route and target and key point of hydropower development in China and present measures and suggestions to hydropower development in future.

  11. Recent scientific advances in leiomyoma (uterine fibroids research facilitates better understanding and management [v1; ref status: indexed, http://f1000r.es/54a

    Directory of Open Access Journals (Sweden)

    Darlene K. Taylor

    2015-07-01

    Full Text Available Uterine leiomyomas (fibroids are the most prevalent medical problem of the female reproductive tract, but there are few non-surgical treatment options. Although many advances in the understanding of the molecular components of these tumors have occurred over the past five years, an effective pharmaceutical approach remains elusive. Further, there is currently no clinical method to distinguish a benign uterine leiomyoma from a malignant leiomyosarcoma prior to treatment, a pressing need given concerns about the use of the power morcellator for minimally invasive surgery. This paper reviews current studies regarding the molecular biology of uterine fibroids, discusses non-surgical approaches and suggests new cutting-edge therapeutic and diagnostic approaches.

  12. In-office rapid volumetric ablation of uterine fibroids under ultrasound imaging guidance: Preclinical and early clinical experience with the Mirabilis transabdominal HIFU treatment system

    Science.gov (United States)

    Leal, José G. Garza; León, Ivan Hernandez; Sáenz, Lorena Castillo; Aguirre, Juan M. Aguilar; Lagos, Joel J. Islas; Parsons, Jessica E.; Darlington, Gregory P.; Lau, Michael P. H.

    2017-03-01

    Mirabilis Medica, Inc. (Bothell, WA, USA) has developed a high-intensity focused ultrasound (HIFU) system for producing rapid transabdominal volumetric ablation of uterine fibroids in an office-based setting. The Mirabilis HIFU Treatment System utilizes integrated ultrasound imaging guidance and short treatment times under 15 minutes. Treatment with the Mirabilis system is generally well tolerated using only oral analgesia without anesthesia or sedation. This paper summarizes certain technical aspects of the Mirabilis HIFU technology, the preclinical development process, and the results of the first in-human clinical study using the Mirabilis system. During preclinical studies, an in vivo transcutaneous porcine lower extremity model was used in a total of 180 adult swine to develop the HIFU treatment regimen parameters. Additionally, 108 excised human uteri with fibroids obtained from scheduled hysterectomies were treated in an ex vivo experimental setup and evaluated. These preclinical activities resulted in a HIFU treatment technique referred to as Mirabilis Shell Ablation, which enables rapid volumetric fibroid ablation by directing the HIFU energy to the outer perimeter of the target volume (the `shell') without insonating its core. This method results in efficient fibroid treatment through a synergistic combination of direct tissue ablation, cooperative heating effects, and indirect ischemic necrosis in the interior of the volume. After refining this technique and performing safety testing in the in vivo porcine model, a clinical pilot study was conducted to assess the initial safety and performance of the Mirabilis HIFU Treatment System for transabdominal treatment of uterine fibroids in eligible women who were scheduled to undergo hysterectomy following treatment with the device. A total of 37 women meeting certain eligibility criteria were treated at two clinical sites in Mexico. Twenty-nine (29) of these 37 women received only prophylactic sublingual

  13. Electromagnetic image guidance in gynecology: prospective study of a new laparoscopic imaging and targeting technique for the treatment of symptomatic uterine fibroids

    OpenAIRE

    Galen, Donald I.

    2015-01-01

    Background Uterine fibroids occur singly or as multiple benign tumors originating in the myometrium. Because they vary in size and location, the approach and technique for their identification and surgical management vary. Reference images, such as ultrasound images, magnetic resonance images, and sonohystograms, do not provide real-time intraoperative findings. Methods Electromagnetic image guidance, as incorporated in the Acessa Guidance System, has been cleared by the FDA to facilitate tar...

  14. Effect of Continuing Nursing on the Mood and Life Quality of Patients with Uterine Fibroids%延续护理对子宫肌瘤患者情绪及生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    李秀青; 卢晓声

    2016-01-01

    depression score of continuing nursing group was significantly reduced compared with that of routine follow-up visit group. The difference was statistically significant (P<0.05). The score in terms of somatization, obsession, interpersonal sensitivity, depression, anxiety, hostility, terror and psychosis for continuing nursing group was significantly reduced compared with that of routine follow-up visit group. The difference was statistically significant (P<0.05).Conclusion Continuing nursing had a positive impact for patients with uterine fibroids on their emotional state and health condition after discharging from hospital.

  15. Magnetic resonance guided focused ultrasound surgery of uterine fibroids-The tissue effects of GnRH agonist pre-treatment

    Energy Technology Data Exchange (ETDEWEB)

    Smart, O.C. [Department of Academic Obstetrics and Gynaecology, St. Mary' s Hospital and Imperial College School of Medicine, Praed Street, London W2 1NY (United Kingdom); Department of Magnetic Resonance Imaging, St. Mary' s Hospital and Imperial College School of Medicine, Praed Street, London W2 1NY (United Kingdom); Hindley, J.T. [Department of Academic Obstetrics and Gynaecology, St. Mary' s Hospital and Imperial College School of Medicine, Praed Street, London W2 1NY (United Kingdom); Regan, L. [Department of Academic Obstetrics and Gynaecology, St. Mary' s Hospital and Imperial College School of Medicine, Praed Street, London W2 1NY (United Kingdom); Gedroyc, W.M.W. [Department of Magnetic Resonance Imaging, St. Mary' s Hospital and Imperial College School of Medicine, Praed Street, London W2 1NY (United Kingdom)]. E-mail: w.gedroyc@imperial.ac.uk

    2006-08-15

    Objective: The purpose of this study was to determine the ablative effect of magnetic resonance guided focused ultrasound (MRgFUS) on fibroid tissue following the administration of gonadotrophin releasing hormone (GnRH) agonist. Study design: Fifty women with clinically symptomatic uterine fibroids were treated. Those with uterine diameter of 10 cm or greater were given 3 months pre-treatment with GnRH agonists. Data regarding number of ultrasound sonications, Joules of energy delivered and volume of thermal destruction was recorded. Results: Twenty-seven subjects were given GnRH agonist therapy before MRgFUS and 23 women underwent MRgFUS without pre-treatment. All patients in both study groups completed MR guided FUS as an outpatient procedure with no device related adverse events reported. In the group of women who received GnRH agonists, the volume of ablation was significantly larger than that in the control group (0.06 cm{sup 3} versus 0.03 cm{sup 3}, P < 0.05), per Joule of energy applied. Conclusion: The use of GnRH agonists potentiates the thermal effects of MRgFUS in women undergoing treatment of uterine fibroids.

  16. A Method of Time-Intensity Curve Calculation for Vascular Perfusion of Uterine Fibroids Based on Subtraction Imaging with Motion Correction

    Science.gov (United States)

    Zhu, Xinjian; Wu, Ruoyu; Li, Tao; Zhao, Dawei; Shan, Xin; Wang, Puling; Peng, Song; Li, Faqi; Wu, Baoming

    2016-12-01

    The time-intensity curve (TIC) from contrast-enhanced ultrasound (CEUS) image sequence of uterine fibroids provides important parameter information for qualitative and quantitative evaluation of efficacy of treatment such as high-intensity focused ultrasound surgery. However, respiration and other physiological movements inevitably affect the process of CEUS imaging, and this reduces the accuracy of TIC calculation. In this study, a method of TIC calculation for vascular perfusion of uterine fibroids based on subtraction imaging with motion correction is proposed. First, the fibroid CEUS recording video was decoded into frame images based on the record frame rate. Next, the Brox optical flow algorithm was used to estimate the displacement field and correct the motion between two frames based on warp technique. Then, subtraction imaging was performed to extract the positional distribution of vascular perfusion (PDOVP). Finally, the average gray of all pixels in the PDOVP from each image was determined, and this was considered the TIC of CEUS image sequence. Both the correlation coefficient and mutual information of the results with proposed method were larger than those determined using the original method. PDOVP extraction results have been improved significantly after motion correction. The variance reduction rates were all positive, indicating that the fluctuations of TIC had become less pronounced, and the calculation accuracy has been improved after motion correction. This proposed method can effectively overcome the influence of motion mainly caused by respiration and allows precise calculation of TIC.

  17. Fracture of the Femur of A Newborn after Cesarean Section for Breech Presentation and Fibroid Uterus : A Case Report and Literature Review.

    Science.gov (United States)

    Farikou, Ibrahima; Bernadette, Ngo Nonga; Daniel, Handy Eone; Aurélien, Sosso Maurice

    2014-01-01

    The practice of cesarean section is known to decrease the occurrence of long bone fractures. We present here an unusual diaphyseal fracture of the femur of a newborn after cesarean section, the only case observed in our 14 years of practice. The patient was a 3.4-kg female child born at 38 weeks of gestation. The mother was a primipara and aged 39 years. Ultrasound examination at 20th week revealed intrauterine fibroids with a breech presentation. Therefore, elective cesarean section was indicated. There was no apparent bone disorder that could predispose to sustain femur fracture. The fracture was treated successfully with a bilateral spica cast. The cesarean section was indicated in an aged primipara, bearer of uterine fibroids, and breech presentation. She had a good general health status, but her bone density was unknown since this examination is not routinely performed in our clinical settings in Africa. Elderly age, primipara status, presence of uterine fibroids, and breech presentation are usual indications for cesarean section. However, there are not many reports on femur fracture after cesarean section. Our present case suggests that despite the latest advances in delivery techniques, cesarean section for breech presentation predisposes the neonate to femoral fractures.

  18. Perfusion volume correlates, percentage of involution, and clinical efficacy at diverse follow-up survey times after MR-guided focused ultrasound surgery in uterine fibroids: first report in a Mexican mestizo population

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco-Choque, Ana Luz; Fernandez-de Lara, Yeni; Vivas-Bonilla, Ingrid; Romero-Trejo, Cecilia [Medica Sur Clinic and Foundation, Magnetic Resonance Unit, Mexico City (Mexico); Villa, Antonio R. [UNAM, Division de Investigacion, Facultad de Medicina, Mexico City (Mexico); Roldan-Valadez, Ernesto [Medica Sur Clinic and Foundation, Magnetic Resonance Unit, Mexico City (Mexico); Medica Sur Clinic and Foundation, Coordination of Research and Innovation, Magnetic Resonance Unit, Mexico City (Mexico)

    2015-10-15

    To evaluate the clinical efficacy of magnetic resonance-guided focused ultrasound surgery in a Mexican mestizo population. This retrospective study included 159 women (mean age 37 ± 6.4 years, range 22-53 years) from 2008 to 2010. Two hundred sixty-eight symptomatic uterine fibroids were treated using MR-guided focused ultrasound surgery. Parameters included initial perfused volume, final perfused volume, non-perfused volume (NPV), and treated volume ratio (TVR). Follow-up up to 15 months assessed treatment efficacy and symptomatic relief. Non-parametric statistics and the Kaplan-Meier method were performed. T{sub 2}-weighted hypointense fibroids showed a frequency of 93.6 %; isointense and hyperintense fibroids had frequencies of 5.60 and 1.1 %. There was a negative correlation between NPV and age (r = -0.083, p = 0.307) and treatment time (r = -0.253, p = 0.001). Median TVR was 96.0 % in small fibroids and 76.5 % in large fibroids. Involution of 50 % and 80 % was achieved at months 6-7 and month 11, respectively. Relief of symptoms was significant (p < 0.05). Our data show that higher TVR attained immediately post-treatment of MRgFUS favours higher involution percentages at follow-up; however, careful patient selection and use of pretreatment imaging are important components for predicting success using MR-guided focused ultrasound surgery. (orig.)

  19. A giant uterine myometrium cyst mimicking an ovarian cyst in pregnancy: An uncommon presentation of hydropic degeneration of uterine fibroid

    Directory of Open Access Journals (Sweden)

    Elsayed Elbadawy Awad

    2015-06-01

    Full Text Available Myometrial cysts of the uterus are extremely rare. Uterine leiomyomas commonly undergo degenerative changes, which can lead to variable imaging features. Diffuse hydropic change is an unusual form that presents a considerable diagnostic challenge to both radiologists and pathologists. A 27-year old nulliparous patient admitted to our hospital for antenatal care and left sided pelvic pain. Transvaginal ultrasonographic examination revealed a 20 cm intramural cystic lesion in the left region of the corpus uteri suspicious of degenerated myoma. Repeated aspiration was done. Spontaneous abortion occurred in the first trimester. Rapid distension of the abdomen despite repeated aspirations occurred. MRI revealed degenerated myoma. Ultrasound performed one day before surgery revealed a turbid content instead of the clear fluid. Laparotomy was performed revealing a huge interstitial myoma with bloody collection inside so, myomectomy was performed. Histopathology showed hydropic degenerated myoma. Although fibroids usually have a characteristic sonographic appearance, degenerating myomas have variable patterns and can pose a diagnostic dilemma. Extensive cystic degeneration can mimic an ovarian tumour.

  20. An Inflammatory Fibroid Polyp in the Hepatic Flexure of the Colon Treated with Argon Plasma Coagulation, Endoscopic Clipping and Polypectomy

    Directory of Open Access Journals (Sweden)

    Ariyo Ihimoyan

    2012-01-01

    Full Text Available Inflammatory fibroid polyp (IFP is a rare benign polypoid lesion of the gastrointestinal tract. Most IFPs occur in the stomach and colonic occurrence is very rare. Histologically IFP is characterized by a mixture of numerous small vessels, fibroblasts and edematous connective tissue associated with marked inflammatory infiltration by eosinophils. We present a rare case of a pedunculated IFP in the hepatic flexure of the colon treated successfully with a combination of argon plasma coagulation, endoclipping and polypectomy. A 74-year-old asymptomatic female underwent a screening colonoscopy in our hospital. A 12-mm pedunculated polyp was found at the hepatic flexure of the colon. After saline injection, we attempted to remove the polyp with a hot snare. However the polyp stalk was extremely difficult to resect despite several attempts with the hot snare. We placed an endoclip at the base of the stalk and then applied argon plasma coagulation at 1.0 l/min and 40 W. After these measures we were able to resect the stalk and the polyp was retrieved. Histologically the polyp was located in the submucosa of the gastrointestinal tract. Proliferation of spindle cells and infiltration of inflammatory cells such as plasma cells and eosinophils were observed. The spindle cells were positive for CD34 and S100 but negative for c-kit and muscle markers. These findings are consistent with a histopathological diagnosis of IFP.

  1. Early ultrasonographic findings after a uterine fibroid embolization: the value of differentiate from procedure-related uterine infection

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Seung Boo; Goo, Dong Erk; Chang, Yun Woo [Soonchunhyang University, Gumi Hospital, Gumi (Korea, Republic of); Choi, Jin Soo [School of Medicine, Keimyung University, Daegu (Korea, Republic of)

    2008-03-15

    To evaluate the early ultrasonographic (US) findings from the uterus and myoma after a uterine fibroid embolization (UFE). From March 2004 to January 2006, eleven patients (27-48 years, mean:37 years) with UFE to treat symptomatic uterine myoma, were retrospectively reviewed. A serial follow up gray-scale and color Doppler US were performed from one day to two weeks following a UFE. The US findings were evaluated for the presence and distribution pattern of air, time of air loss, and presence of fluid collection in the uterine cavity and color Doppler (SD Comment: Doppler is name. Should perhaps be upper case) signal. Numerous high echoes with reverberation artifacts (which suggest air), were observed within the myoma (in all cases), one day after UFE. A branching linear echo pattern was observed in 4 cases (36%), whereas scattered echoes were observed in 7 cases (64%). Progressive loss of air, within 7 days of a UFE, was observed in 9 cases (82%), whereas 2 cases (12%) were observed within 14 days of a UFE. Abnormal fluid collection in the uterine cavity and a color Doppler signal within the myoma was not observed for all cases. Branching or scattered echoes (suggesting air), are normally found within the myoma after a UFE, but these echoes disappeared within 2 weeks. These early US findings can be useful in differentiating from myoma infections after a UFE.

  2. The Dual Action of Varunadi Kwath in Renal Calculi as well as Uterine Fibroid- A Case Study

    Directory of Open Access Journals (Sweden)

    Padavi D. M.

    2015-09-01

    Full Text Available Mutrashmari (Renal Calculi is very common disorder. This distressing urinary disorder affects around 5-7 million people in India [11]. The chances of recurrence are always high and the surgery having disadvantage of high cost. The available treatment in modern science is only conservative and surgical in this present study an effort was made to evaluate the role of Varunadi Kwath in Mutrashmari. The main aim of this particular study was inclined towards the disintegration, dissolution, dislodgement and expulsion of renal calculi. The contents of Varunadi Kwath are easily available, economical and are easy to administer, which are having Anti-inflammatory, Diuretic and Antilithic properties. A case of renal calculi with uterine fibroid was diagnosed and the treatment was given for a period of 9 months. The size of the calculus was studied by periodic ultrasonography; the symptoms Mutrakruchrata (Dysuria, Shula (Pain in abdomen, Sadaha Mutrata (Burning micturition are significantly reduced within less than 45 days and total expulsion of calculi in less than 180 days.

  3. Simulation study of the effects of near- and far-field heating during focused ultrasound uterine fibroid ablation using an electronically focused phased array: A theoretical analysis of patient safety

    Energy Technology Data Exchange (ETDEWEB)

    Ellens, Nicholas, E-mail: nicholas.ellens@utoronto.ca; Hynynen, Kullervo [Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)

    2014-07-15

    Purpose: Assess the feasibility of using large-aperture, flat ultrasonic transducer arrays with 6500 small elements operating at 500 kHz without the use of any mechanical components for the thermal coagulation of uterine fibroids. This study examines the benefits and detriments of using a frequency that is significantly lower than that used in clinical systems (1–1.5 MHz). Methods: Ultrasound simulations were performed using the anatomies of five fibroid patients derived from 3D MRI. Using electronic steering solely, the ultrasound focus from a flat, 6500-element phased array was translated around the volume of the fibroids in various patterns to assess the feasibility of completing full treatments from fixed physical locations. Successive temperature maps were generated by numerically solving the bioheat equation. Using a thermal dose model, the bioeffects of these simulations were quantified and analyzed. Results: The simulations indicate that such an array could be used to perform fibroid treatments to 18 EM{sub 43} at an average rate of 90 ± 20 cm{sup 3}/h without physically moving the transducer array. On average, the maximum near-field thermal dose for each patient was below 4 EM{sub 43}. Fibroid tissue could be treated as close as 40 mm to the spine without reaching temperatures expected to cause pain or damage. Conclusions: Fibroids were successfully targeted and treated from a single transducer position to acceptable extents and without causing damage in the near- or far-field. Compared to clinical systems, treatment rates were good. The proposed treatment paradigm is a promising alternative to existing systems and warrants further investigation.

  4. 三维数字化模型在子宫肌瘤术前规划中的应用%The Application of Three-dimensional Models for the Preoperative Planning of the Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    薛迎峰; 王栋; 张璐; 宗丽菊; 张友忠

    2015-01-01

    To explore the significance of the individualized preoperative planning with three‐dimensional (3D) models of the uterus and uterine fibroids via applying 3D reconstruction and virtual reality techniques based on MRI scan data .The MRI scan data of the 25 enrolment patients with uterine fibroids were collected .The MRI scan data of the uterus and uterine fibroids was transferred to the self‐developed 3D preoperative planning software for 3D reconstruction and spatial analysis . The 3D models of the uterus and uterine fibroids were reconstructed successfully .The complex internal spatial structure of the 3D models of the uterus and uterine fibroids can be intuitively displayed .Gynecologists can perform various operations on the 3D models ,such as rotation ,scaling ,painting ,transparency adjustment ,measuring and moving ,to judge the type of the uterine fibroids accurately .The accurate judgment can guide gynecologists to select the individualized surgery .The self‐developed 3D preoperative planning software can provide an ideal platform for selecting the scientific treatment planning of uterine fibroids gynecological surgery . Applying this software , the type of uterine fibroids and the individualized preoperative planning can be decided .%应用三维重建及虚拟现实技术构建子宫肌瘤数字化模型,探讨三维模型在不同类型子宫平滑肌瘤术前个体化手术规划中的意义。收集盆腔M RI检查子宫肌瘤患者25例。将M RI原始数据集中的子宫及其平滑肌瘤进行三维重建及空间分析。成功重建出结构清晰、三维效果逼真、立体感强,可真实反映子宫及病灶实际空间结构关系的三维模型,并可进行旋转、放大、缩小、上色、透明度选择、测量及移动等操作,通过观察、测量病灶大小、数目、位置、临近解剖关系精确判断肌瘤的8种类型,可成功实现肌瘤分型,以指导选择个体化手术治疗方案。

  5. EFFECTIVENESS AND SAFETY OF MIFEPRISTONE IN DIFFERENT DOSE (10 MG AND 25 MG FOR THE TREATMENT OF UTERINE FIBROIDS AND TO EVALUATE QUALITY OF LIFE

    Directory of Open Access Journals (Sweden)

    Pratibha Rai

    2016-07-01

    Full Text Available BACKGROUND Mifepristone is Selective Progesterone Receptor Modulators (SPRMS and is emerging as a best medical treatment increasing the quality of life as well as saving the patient from surgery. This drug has shown great effectiveness, e.g.: 2.5 mg, 5 mg and 10 mg, but with less reduction in uterine volume as well as reduction in fibroids size. Ref. 1 Yang Y et al. AIM The aim of this study was to evaluate the safety and improvement of life pattern using 10 mg and 25 mg daily doses of Mifepristone for six months with a nine month follow-up period for the regress of fibroids as well as uterine volume to improve quality of life without any surgery in premenopausal women with complaint of menorrhagia, dysmenorrhoea, abdominal discomfort, dyspareunia, rectal pain, urinary problem and weakness due to anaemia. DESIGN The research was a randomized double blind clinical study undertaken at Patliputra Medical College Hospital, Dhanbad (Jharkhand. SEARCH METHOD I had searched a number of international journals, reference lists, databases and ongoing trails and the internet. Also searched the specialised register of Cochrane menstrual disorders and subfertility (Cochrane menstrual disorder and subfertility. The Cochrane central register of control trails (Central. The Cochrane library 2011, Issue 4. METHODOLOGY The trial was done on 100 patients. Patients were divided into two equal groups (All were with symptomatic uterine fibroids to evaluate safety as well as quality of life. Dose decided was 10 mg (A and 25 mg (B of Mifepristone. Subjects were taken from Gynaecological outdoor of Patliputra Medical College Hospital, Dhanbad, (Jharkhand, after taking their consent. All women were between the age group of 35 to 48 years with symptomatic multiple fibroids of various sizes and site. At enrolment patients of both groups underwent clinical assessment, Per Abdomen (P/A and Per Vaginal (P/V examination, USG for uterine volume and size of fibroid. Endometrial

  6. The management of uterine fibroids in women with otherwise unexplained infertility.

    Science.gov (United States)

    Carranza-Mamane, Belina; Havelock, Jon; Hemmings, Robert; Cheung, Anthony; Sierra, Sony; Carranza-Mamane, Belina; Case, Allison; Dwyer, Cathie; Graham, James; Havelock, Jon; Hemmings, Robert; Liu, Kimberly; Murdock, Ward; Vause, Tannys; Wong, Benjamin; Burnett, Margaret

    2015-03-01

    Objectif : Formuler des recommandations quant à la façon optimale d’assurer la prise en charge des fibromes dans le contexte de l’infertilité. Les options habituelles et novatrices de prise en charge des fibromes seront analysées en mettant l’accent sur leur applicabilité chez les femmes qui souhaitent obtenir une grossesse. Options : La prise en charge des fibromes chez les femmes qui souhaitent obtenir une grossesse met d’abord en jeu la documentation de la présence des fibromes en question et la détermination de la probabilité que ces derniers affectent le potentiel génésique. Dans un tel contexte, la prise en charge des fibromes s’effectue principalement de façon chirurgicale; toutefois, il faut s’assurer au préalable de mettre en balance les avantages factuels de l’approche chirurgicale en matière d’amélioration des issues cliniques et les risques propres à une telle approche. Issues : L’amélioration des taux et des issues de grossesse que permet la prise en charge des fibromes chez les femmes aux prises avec l’infertilité constitue l’issue principale sur laquelle nous nous sommes attardés. Résultats : La littérature publiée a été récupérée par l’intermédiaire de recherches menées dans PubMed, CINAHL et Cochrane Systematic Reviews en novembre 2013 au moyen d’un vocabulaire contrôlé (p. ex. « leiomyoma », « infertility », « uterine artery embolization », « fertilization in vitro ») et de mots clés (p. ex. « fibroid », « myomectomy ») appropriés. Les résultats ont été restreints aux analyses systématiques, aux études observationnelles et aux essais comparatifs randomisés / essais cliniques comparatifs publiés en anglais et français. Aucune restriction n’a été appliquée en matière de date. Les recherches ont été mises à jour de façon régulière et intégrées à la directive clinique jusqu’en novembre 2013. La littérature grise (non publiée) a

  7. Epidural Analgesia Versus Patient-Controlled Analgesia for Pain Relief in Uterine Artery Embolization for Uterine Fibroids: A Decision Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kooij, Sanne M. van der, E-mail: s.m.vanderkooij@amc.uva.nl; Moolenaar, Lobke M.; Ankum, Willem M. [Academic Medical Centre, Department of Gynaecology (Netherlands); Reekers, Jim A. [Academic Medical Centre, Department of Radiology (Netherlands); Mol, Ben Willem J. [Academic Medical Centre, Department of Gynaecology (Netherlands); Hehenkamp, Wouter J. K. [VU University Medical Centre, Department of Gynaecology (Netherlands)

    2013-12-15

    Purpose: This study was designed to compare the costs and effects of epidural analgesia (EDA) to those of patient-controlled intravenous analgesia (PCA) for postintervention pain relief in women having uterine artery embolization (UAE) for systematic uterine fibroids. Methods: Cost-effectiveness analysis (CEA) based on data from the literature by constructing a decision tree to model the clinical pathways for estimating the effects and costs of treatment with EDA and PCA. Literature on EDA for pain-relief after UAE was missing, and therefore, data on EDA for abdominal surgery were used. Outcome measures were compared costs to reduce one point in visual analogue score (VAS) or numeric rating scale (NRS) for pain 6 and 24 h after UAE and risk for complications. Results: Six hours after the intervention, the VAS was 3.56 when using PCA and 2.0 when using EDA. The costs for pain relief in women undergoing UAE with PCA and EDA were Euro-Sign 191 and Euro-Sign 355, respectively. The costs for EDA to reduce the VAS score 6 h after the intervention with one point compared with PCA were Euro-Sign 105 and Euro-Sign 179 after 24 h. The risk of having a complication was 2.45 times higher when using EDA. Conclusions: The results of this indirect comparison of EDA for abdominal surgery with PCA for UAE show that EDA would provide superior analgesia for post UAE pain at 6 and 24 h but with higher costs and an increased risk of complications.

  8. Complications and Reinterventions in Uterine Artery Embolization for Symptomatic Uterine Fibroids: A Literature Review and Meta Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Jason, E-mail: Jason.martin@medportal.ca; Bhanot, Kunal, E-mail: Kunal.Bhanot@medportal.ca [Michael G. DeGroote School of Medicine, McMaster University (Canada); Athreya, Sriharsha, E-mail: harshavbs@yahoo.com [St. Joseph' s Health Care Hamilton, McMaster University, Faculty of Health Sciences (Canada)

    2013-04-15

    To perform a literature review of the spectrum of complications associated with UAE relative to surgery and compare the risk of reintervention as well as minor, major, and overall complications. Literature review was conducted in PubMed, MEDLINE, Cochrane, and CINAHL databases, and meta-analysis was performed. In randomized clinical trials, common complications were discharge and fever (4.00 %), bilateral uterine artery embolization (UAE) failure (4.00 %), and postembolization syndrome (2.86 %). Two trials showed a significantly decreased risk in major complications with UAE, with odds ratios (ORs) of 0.07143 (0.009426-0.5413) and 0.5196 (0.279-0.9678). None of the trials showed a significant difference in OR for minor complications of UAE. None of the trials showed a significant difference in risk for overall complications of UAE. Three trials showed a significantly increased risk for reintervention with UAE with ORs of 10.45 (2.654-41.14), 2.679 (1.289-5.564), and 9.096 (1.269-65.18). In 76 nonrandomized studies, common complications were amenorrhea (4.26 %), pain (3.59 %), and discharge and fever (3.37 %). In 41 case studies, common complications were discharge and fever (n = 22 cases), repeat UAE (n = 6 cases), and fibroid expulsion (n = 5 cases). Overall, UAE has a significantly lower rate of major complications relative to surgery, but it comes at the cost of increased risk of reintervention in the future. Educating patients about the rate and types of complications of UAE versus surgery, as well as the potential for reintervention, should help the patient and clinician come to a reasoned decision.

  9. Needle knife-assisted endoscopic polypectomy for a large inflammatory fibroid colon polyp by making its stalk into an omega shape using an endoloop.

    Science.gov (United States)

    Kim, Byung Chang; Cheon, Jae Hee; Lee, Sang Kil; Kim, Tae Il; Kim, Hoguen; Kim, Won Ho

    2008-08-30

    Colonic inflammatory fibroid polyp (IFP) is an uncommon benign polypoid lesion, which is composed of fibroblasts, numerous small vessels and edematous connective tissue with marked eosinophilic inflammatory cell infiltration. This condition is frequently detected in the stomach and small intestine, but uncommon in the colon. Although IFP is a benign lesion, surgical resections are performed in most colonic cases because the polyps are usually too large to resect endoscopically. Only three patients underwent endoscopic polypectomy in our literature reviews. Here, we present a case of IFP in the descending colon successful endoscopically resected using a novel technique of trapping its stalk with an endoloop, forming the stalk into an omega shape, and then dissecting the stalk with a needle knife.

  10. Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids.

    Science.gov (United States)

    Seitz, Christian; Bumbuliene, Žana; Costa, Ana Rosa; Heikinheimo, Oskari; Heweker, Andrea; Hudeček, Robert; Jacquemyn, Yves; Melis, Gian Benedetto; Parashar, Pooja; Rechberger, Tomasz; Sánchez, Antonio Cano; van Aken, Bart; Zatik, János; Gemzell-Danielsson, Kristina

    2017-04-01

    Uterine fibroids (UFs) may be treated with progesterone receptor modulators (PRMs), which have been shown to reduce heavy menstrual bleeding and the size of UFs. To date, one PRM (ulipristal acetate) has received regulatory approval for the treatment of UFs; therapy comprises intermittent treatment courses of up to 3months each, followed by a break to allow two menstruations to occur. We report the design of ASTEROID (Assess Safety and efficacy of vilaprisan in patients with uTERine fibrOIDs) 2, a phase 2 study examining the efficacy and safety of a novel PRM, vilaprisan, in women with UFs. In this randomized multi-arm study, vilaprisan (2mg daily) will be administered in different regimens: continuous treatment for 12 or 24weeks, or two 12-week treatment periods separated by a break to allow one menstruation to occur. Efficacy and safety will be compared with that of ulipristal acetate (5mg daily) and placebo. Patients randomized to receive placebo for 12weeks will also be given active treatment for 12weeks. The primary measure of efficacy will be amenorrhoea rate; secondary measures include time to normalized menstrual bleeding and percentage change in UF volume. Endometrial changes will be monitored throughout the study. The placebo- and active comparator-controlled trial ASTEROID 2 is the first study to evaluate systematically the efficacy and safety of different treatment regimens of PRMs in women with UFs. The findings of this study will direct the planning of future clinical trials of vilaprisan. Copyright © 2017 Bayer AG. Published by Elsevier Inc. All rights reserved.

  11. 围绝经期子宫肌瘤及子宫腺肌病所致异常出血%Perimenopausal abnormal bleeding caused by uterine fibroids and uterine adenomyosis

    Institute of Scientific and Technical Information of China (English)

    汪利群; 黄欧平

    2012-01-01

    Uterine fibroids and adenomyosis is the most common benign gynecological diseases, they are one important reason for abnormal uterine bleeding in perimenopausal period. This article summarizes the e-tiology, diagnosis and treatment of abnormal uterine bleeding caused by fibroids and adenomyosis in perimenopausal women,which should lead to attention.%子宫肌瘤与子宫腺肌病是妇科最常见的良性肿瘤,是导致围绝经期子宫异常出血的重要原因之一.该文概述了子宫肌瘤与子宫腺肌病导致围绝经期异常子宫出血病因、诊断及治疗,以期引起关注.

  12. Living with uterine fibroids

    Science.gov (United States)

    ... Advisor 2016 . Philadelphia, PA: Elsevier; 2016:1271-1272. Katz VL. Benign gynecologic lesions: Vulva, vagina, cervix, uterus, oviduct, ovary. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. ...

  13. Uterine Fibroid Embolization (UFE)

    Science.gov (United States)

    ... resembling coarse sand Gelfoam™, a gelatin sponge material microspheres, polyacrylamide spheres with a gelatin coating All of ... who wishes to have more children consider surgical removal of the individual tumors rather than undergo uterine ...

  14. Diffusion-weighted magnetic resonance imaging using different b-value combinations for the evaluation of treatment results after volumetric MR-guided high-intensity focused ultrasound ablation of uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Ikink, Marlijne E.; Voogt, Marianne J.; Bosch, Maurice A.A.J. van den; Nijenhuis, Robbert J. [University Medical Center Utrecht, Department of Radiology, Utrecht (Netherlands); Keserci, Bilgin [Samsung Medical Center, High-intensity Focused Ultrasound (HIFU) Center, Seoul (Korea, Republic of); Philips Healthcare, Advanced Science and Development, Seoul (Korea, Republic of); Kim, Young-sun [Samsung Medical Center, High-intensity Focused Ultrasound (HIFU) Center, Seoul (Korea, Republic of); Samsung Medical Center, Sunkyunkwan University, Department of Radiology and Center for Imaging Science, Seoul (Korea, Republic of); Vincken, Koen L.; Bartels, Lambertus W. [University Medical Center Utrecht, Department of Radiology and Image Sciences Institute, Utrecht (Netherlands)

    2014-09-15

    To assess the value of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) mapping using different b-value combinations for treatment evaluation after magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) of uterine fibroids. Fifty-six patients with 67 uterine fibroids were treated with volumetric MR-HIFU. Pre-treatment and post-treatment images were obtained using contrast-enhanced T1-weighted MRI (CE-T1WI) and DWI using b = 0, 200, 400, 600, 800 s/mm{sup 2}. ADC maps were generated using subsets of b-values to investigate the effects of tissue ablation on water diffusion and perfusion in fibroids treated with MR-HIFU. Four combinations of b-values were used: (1) all b-values; (2) b = 0, 200 s/mm{sup 2}; (3) b = 400, 600, 800 s/mm{sup 2}; and (4) b = 0, 800 s/mm{sup 2}. Using the lowest b-values (0 and 200 s/mm{sup 2}), the mean ADC value in the ablated tissue reduced significantly (p < 0.001) compared with baseline. Calculating the ADC value with the highest b-values (400, 600, 800 s/mm{sup 2}), the ADC increased significantly (p < 0.001) post-treatment. ADC maps calculated with the lowest b-values resulted in the best visual agreement of non-perfused fibroid tissue detected on CE images. Other b-value combinations and normal myometrium showed no difference in ADC after MR-HIFU treatment. A decrease in contrast agent uptake within the ablated region on CE-T1WI was correlated to a significantly decreased ADC when b = 0 and 200 s/mm{sup 2} were used. (orig.)

  15. 妊娠合并巨大子宫肌瘤17例临床分析%Clinical Analysis of 17 Cases of Pregnancy Complicated with Gigantic Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    晋兴林; 花怀珍

    2014-01-01

    0bjective:To explore the management of pregnancy complicated with gigantic uterine fibroids in ce-sarean section.Methods:A retrospective case-control study was done to review the clinical data of 17 cases of preg-nancy with gigantic uterine fibroids (A group),17 cases of pregnancy with fibroids (B group), 17 cases of pregnancy without fibroids (C group).The operation time,blood loss,postpartum hemorrhage,peuparium infection and hospital-ization days were compared.Results:The mean operative time in group A was significantly longer than group B、C (P0.05).Conclusions:Myomectomy of gigantic uterine fibroids during Cesarean section is safe and feasible,but careful perioperative management is very critical.%目的:探讨妊娠合并巨大子宫肌瘤的剖宫产术中的处理方式。方法:选择某医院妊娠合并巨大子宫肌瘤17例(A组)、妊娠合并子宫肌瘤17例(B组)及单纯行剖宫产17例(C组)的患者临床资料进行回顾性分析。对手术时间、术中失血量、产后出血情况、产褥感染率、术后住院天数等指标进行比较。结果:研究组A组的手术时间、术中出血量、产后出血例数明显高于对照组B、C组(P0.05)。结论:剖宫产术中同时处理巨大子宫肌瘤安全、可行,但必须强调整个围手术期管理的重要性。

  16. HEALTHY AND PATHOLOGICAL CHANGES OF MYOMETRIUM: PREGNANT MYOMETRIUM, UTERINE FIBROIDS AND LEIOMYOSARCOMA. Cambios normales y patológicos del miometrio: miometrio del embarazo, fibrosis uterina y leiomiosarcoma

    Directory of Open Access Journals (Sweden)

    Pasquapina Ciarmela

    2016-03-01

    Full Text Available El miometrio, la pared muscular del útero, puede modificar su misma masa y las propiedades celulares en el embarazo y también en los tumores como el leiomioma y el leiomiosarcoma. El leiomioma, dicho también fibroma, es un tumor benigno del útero y se considera como  una de las causas más frecuentes de infertilità en el período reproductivo femenino. El leiomiosarcoma, en cambio, es un tumor maligno y agresivo de la musculatura lisa uterina. La presente revisión discute las características generales del leiomioma y el leiomiosarcoma y los relativos tratamientos clínicos actualmente usados y además describe las características del miometrio normal en el embarazo.  The myometrium, the muscular wall of the uterus, can modify its mass and cellular properties in pregnancy as well as in tumor conditions such as leiomyoma and leiomyosarcoma. Leiomyomas, also known as fibroids, are benign tumors of the uterus, considered to be one of the most frequent causes of infertility in reproductive years of women. Leiomyosarcomas in turn, are rare aggressive malignant uterine smooth-muscle tumors. The present review is discussing the general features of leiomyoma and leiomyosarcoma with their current treatments and also discussing the characteristics of normal pregnant myometrium and compare with leiomyoma.

  17. 子宫肌瘤变性继发血小板升高一例并文献分析%An analysis of one case of uterine fibroids degeneration secondary to platelet elevated

    Institute of Scientific and Technical Information of China (English)

    张甦; 仲丽丽; 韩凤娟; 吴效科

    2013-01-01

      子宫肌瘤变性是指肌瘤失去原有的典型结构,可能引起腹痛等症状,子宫肌瘤合并腹痛、感染、变性,合并血液改变非常少见;本文报道一例子宫肌瘤变性继发血小板升高罕见病例;临床医师应该认识到排除血液系统疾病,抗炎治疗血小板仍然处于高水平状态,可提示血液改变可能与子宫肌瘤变性、感染有关,为以后的临床治疗提供诊治思路。%Uterine fibroids degeneration refers to the fibroid losing its original typical structure,which can be leaded to the symptoms of abdominal pain,uterine fibroids with abdominal pain, infection, modifying,and then degenerating blood changes is very rare. This paper reported a rare cases of a secondary increased platelet following uterine myoma degeneration, clinicians should recognize that blood change may be associated with uterine myoma degeneration and infection if anti-inflammatory treatment platelets were still in a state of high level and no other blood system diseases, this study would provide an idea for future clinical diagnosis and treatment.

  18. Ulipristal acetate for pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands: cost minimization analysis and budget impact analysis.

    Science.gov (United States)

    Zakiyah, N; van Asselt, A D I; Postma, M J

    2017-03-01

    Ulipristal acetate has been found to be non-inferior to other pre-operative treatments of uterine fibroids, particularly leuprolide. The objective of this study was to assess the pharmacoeconomic profile of ulipristal acetate compared to leuprolide for the pre-operative treatment of moderate-to-severe uterine fibroids in women of reproductive age in The Netherlands. The analysis was performed and applied within the framework of the ulipristal acetate submission for reimbursement in 2012. A decision model was developed to compare the total costs of ulipristal acetate compared to leuprolide, the standard care in The Netherlands. The target population of this study corresponded to the type of patients included in the PEARL II clinical trial; i.e. women of reproductive age requiring pre-operative treatment for uterine fibroids. Sensitivity analysis was implemented to assess uncertainties. Data regarding costs, effects, and other input parameters were obtained from relevant published literatures, the Dutch Healthcare Insurance Board, and expert opinion obtained by means of a panel of experts from several medical centers in The Netherlands. In The Netherlands, the total costs of ulipristal acetate and leuprolide were estimated at €4,216,027 and €4,218,095, respectively. The annual savings of ulipristal acetate were, therefore, estimated at €2,068. The major driver of this cost difference was the cost of administration for leuprolide. Sensitivity analyses showed that ulipristal acetate mostly remained cost-saving over a range of assumptions. The budget impact analysis indicated that the introduction of ulipristal acetate was estimated to result in cost savings in the first 3 years following the introduction. The results of this study were used in the decision on reimbursement of ulipristal acetate according to the Dutch Reference Pricing system in 2012. Ulipristal acetate was cost saving compared to leuprolide and has the potential to provide substantial savings on

  19. Clinical outcome of magnetic-resonance-guided focused ultrasound surgery (MRgFUS) in the treatment of symptomatic uterine fibroids; Klinische Ergebnisse der Behandlung symptomatischer Uterusmyome mittels MRgFUS (Magnetresonanztomografie-gesteuerter fokussierter Ultraschall)

    Energy Technology Data Exchange (ETDEWEB)

    Kamp, J.E.K.; Scheurig-Muenkler, C.; Beck, A. [Charite - Universitaetsmedizin Berlin (Germany). Klinik fuer Radiologie; David, M. [Charite - Universitaetsmedizin Berlin (Germany). Klinik fuer Gynaekologie; Hengst, S. [Klinikum Barnim GmbH, Werner Forssmann Krankenhaus, Eberswalde (Germany). Klinik fuer Radiologie

    2013-02-15

    Purpose: To investigate the clinical outcome of magnetic-resonance-guided focused ultrasound surgery (MRgFUS) treatment for symptomatic uterine fibroids in premenopausal women using the validated USF-QOL (Uterine Fibroid Symptom and Quality of Life) Questionnaire. Materials and Methods: 54 patients with symptomatic uterine fibroids were enrolled in this prospective study. The patients completed the UFS-QOL Questionnaire prior to MRgFUS treatment as well as after 3, 6, and 12 months. Results: The rate of technical success was 91.5 % (95.2 % after subtraction of screening errors). 6/54 patients (11 %) had other treatments (surgery, n = 4; UAE, n = 2), 8/54 (15 %) dropped out due to pregnancy, and 8/54 were lost to follow-up. The remaining group showed considerable symptom relief as early as after 3 months. The median overall quality of life score increased from 64.7 (quartile range QR: 49.8 - 77.6) before treatment to 77.6 (QR: 61.4 - 87.1) (p < 0.001), 78.4 (QR: 66.4 - 89.7) (p < 0.001), and 82.8 (QR: 69.8 - 92.2) (p < 0.001) at 3, 6, and 12 months, respectively. The corresponding median symptom severity score decreased from 46.9 (QR: 28.1 - 56.2) to 34.4 (QR: 21.9 - 43.7) at 3 months (p = 0.003) and 28.1 at 6 and 12 months (QR: 18.7 - 38.3, QR: 15.6 - 34.4) (p < 0.001, p = 0.002). The rate of complications requiring treatment was 9 %, and the rate of overall complications was 39 %. No major complications occurred. Conclusion: Our results indicate significant alleviation of fibroid-related symptoms within 12 months of MRgFUS with improvement beginning as early as 3 months after treatment. We observed no major complications, and some women became pregnant after MRgFUS. There was a low treatment failure rate of 11 %. (orig.)

  20. 不同手术方法治疗子宫肌瘤对患者性功能影响的临床研究%Effect of different treating methods for uterine fibroids on the sexual function of patients

    Institute of Scientific and Technical Information of China (English)

    郑蕊; 薛惠英; 胡捷

    2014-01-01

    目的:探讨子宫肌瘤剔除术与子宫次全切除术对患者性功能的影响,并对患者的性功能情况及婚姻质量情况进行调查分析。方法:选择2011年4月至2013年11月期间在我院接受诊治的子宫肌瘤患者114例作为研究对象。根据不同手术方式将114例患者分为观察组(n=57)与对照组(n=57)。观察组行子宫肌瘤剔除术,对照组行子宫次全切除术;对比分析两组患者性功能情况及婚姻质量情况。结果:两组患者术前性功能对比无显著性意义;观察组术后6个月在性欲方面、性高潮方面、性心理方面、射精时间、性唤起方面及性行为中异常症状评分显著高于对照组,且有显著性意义(P<0.05);两组患者术前婚姻质量对比无显著性意义;观察组在术后6个月性生活、夫妻交流及婚姻满意度评分均显著高于对照组,且有显著性意义(P<0.05)。结论:子宫肌瘤剔除术临床效果好且对患者性功能及婚姻质量影响小,故对于子宫肌瘤患者应尽可能保留子宫,具有重要临床意义。%To investigate the effect of myomectomy and hysterectomy surgery on the sexual function of patients,and to investigate the situation of sexual function and marital quality of patients.Methods:1 14 patients with uterine fibroids in our hospital from April 201 1 to November 2013 were selected as study objects and divided into two groups observation group (n=57)and control group (n=57)according to the surgical approach. Observation group underwent myomectomy,while the control group underwent hysterectomy surgery.The sexual function and marital quality of the two groups were compared and analyzed.Results:No significant difference could be found before treatment.Six months after the treatment,the scores of observation group were much higher than the control group in terms of sexual desire,orgasm,sexual psychology,ejaculation,sexual arousal and abnormal

  1. Inflammatory fibroid polyp: an immunohistochemical study Pólipo inflamatório fibróide: estudo imunoistoquímico

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    Gilda da Cunha Santos

    2004-06-01

    Full Text Available BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56. RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.RACIONAL: O pólipo inflamatório fibróide é uma lesão localizada que se origina na submucosa do trato gastrointestinal, mais freqüentemente do estômago. Embora se acredite que represente condição reativa e não neoplásica, sua histogênese permanece controversa. OBJETIVO: Estudar o pólipo inflamatório fibróide por imunoistoquímica na tentativa de contribuir para o entendimento de sua histogênese. PACIENTES AND MÉTODOS: Foram estudados nove casos por imunoistoquímica usando-se um

  2. Clinicopathologic features of inflammatory fibroid polyp of the esophagus%食管炎性纤维性息肉的临床病理特征

    Institute of Scientific and Technical Information of China (English)

    谢飞来; 姚丽青; 余英豪

    2012-01-01

    目的:探讨食管炎性纤维性息肉(inflammatory fibroid polyp,IFP)的临床病理学特征、诊断、鉴别诊断、治疗方法和预后.方法:报道1例罕见的食管IFP,对其进行光镜观察、免疫组织化学染色,并结合文献探讨该病的临床病理学特征.结果:患者为71岁的男性,因进行性吞咽困难3 mo余入院,内镜检查发现食管黏膜距门齿约35 cm处可见一大小约2.5 cm半球状黏膜隆起,超声内镜见一起源于黏膜层大小约13.2 mm×11 mm低回声团块,回声欠均匀,其间可见无回声影,边界尚清晰.入院完善相关检查后在全麻下行食管占位切除术,术后病理显示肿瘤位于黏膜下层,向食管管腔内隆起生长,肿瘤主要由3种成分构成:明显增生的梭形细胞、大量的炎症细胞和血管网,最后诊断为炎性纤维性息肉.结论:食管IFP是一种罕见的间叶源性肿瘤,术前诊断困难,确诊依靠术后病理检查.以外科手术或内镜下肿物完整切除为主要治疗方法,预后良好.%AIM: To explore the clinical and pathological features of inflammatory fibroid polyp (IFP) of the esophagus and to discuss its diagnosis, differential diagnosis, treatment and prognosis.METHODS: A case of IFP of the esophagus was investigated by light microscopy and immuno-histochemistry. A literature review was then performed to summarize the clinical and pathological features of the disease.RESULTS: A 71-year-old man presented with epigastric/retrosternal pain and dysphagia for 3 months. Endoscopy revealed a hemispheric lesion, 2.5 cm in size, in the esophageal mucosa about 35 cm from incisors. On EUS, the lesion (13.2 mm × 11 mm) was hypoechogenic and inho-mogeneous, and was located under the mucosa of the esophagus, with a clear boundary. Surgical resection of the esophageal mass was performed,and the final pathologic diagnosis was IFP of the esophagus.CONCLUSION: IFP of the esophagus is an extremely rare mesenchymal tumor with benign behavior

  3. Transarterial embolization for uterine fibroids: clinical success rate and results of magnetic resonance imaging; Transarterielle Embolisation bei Uterus myomatosus: klinische Erfolgsrate und kernspintomographische Ergebnisse

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    Kroencke, T.J.; Scheurig, C.; Kluener, C.; Fischer, T.; Klessen, C.; Rudolph, J.; Siara, K.; Zimmermann, E.; Hamm, B. [Inst. fuer Radiologie, Charite Universitaetsmedizin Berlin, Campus Mitte, Humboldt-Univ. zu Berlin (Germany); Gauruder-Burmester, A. [Klinik fuer Frauenheilkunde und Geburtshilfe, Charite Universitaetsmedizin Berlin, Campus Mitte, Humboldt-Univ. zu Berlin (Germany); Gronewold, M. [Klinik und Poliklinik fuer Frauenheilkunde und Geburtshilfe, Universitaetsklinikum Hamburg-Eppendorf (Germany)

    2005-01-01

    Purpose: to analyze the clinical success rate and the findings of magnetic resonance imaging (MRI) after uterine artery embolization of symptomatic leiomyomas (fibroids) of the uterus. Materials and methods: this is a prospective single-center case study of 80 consecutively treated patients, followed for 3-6 months (group I), 7-12 months, (group II), and 13-25 months (group III). MRI was used to determine the uterine volume and size of the dominant leiomyoma. Symptoms and causes requiring repeat interventions were analyzed. Results: significant (p < 0.01) volume reduction of the uterus (median: 34.95% confidence interval [CI]: 30.41 - 41.76%) and dominant leiomyoma (median: 52.07%, CI: 47.71 - 61.57%) was found. The decrease in uterine volume (I-III: 22.68%, 33.56%, 47.93%) and dominant leiomyoma volume (I-III: 41.86%, 62.16%, 73.96%) progressed with the follow-up time. Bleeding resolved significantly (p < 0.0001) in all three follow-up groups (groups I-III: 92.86%, 95.23%, 96.67%). Furthermore, urinary frequency (groups I-III: 70%, 75%, 82.35%) and sensation of pelvic pressure (groups I-III: 42.86%, 60%, 93.75%) improved, which was statistically significant in group III (p < 0.01). The number of leiomyomas correlated (p < 0.05) with improvement of the bleeding and the pelvic pressure. Repeat therapy was necessary for complications in four patients (5%) and for therapeutic failure in three patients (3.8%). Permanent amenorrhea was observed in four patients (5%) of age 45 years or older. Conclusion: uterine artery embolization of uterine leiomyomas has a high clinical success rate with an acceptable incidence of complications and repeat interventions. (orig.)

  4. Effect of uterine fibroids on fetal growths and neonatal outcomes in twin pregnancies%子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响

    Institute of Scientific and Technical Information of China (English)

    王红梅; 代荫梅; 田玉翠; 薛智方

    2015-01-01

    Objective To prospectively estimate the effect of fibroids on fetal growths and neonatal outcomes in twin pregnancies. Methods Data of 46 twin pregnancies with fibroids delivered from June 2013 to December 2014 in Beijing Obstetrics and Gynecology Hospital, Capital Medical University who have already established their records were collected. And data were also collected from 63 twin pregnancies without fibroids as matched group. The monitoring parameters of ultrasounds in their early, middle and late pregnancy and neonatal conditions and obstetric outcomes were observed and recorded. Results Twin pregnancies with fibroids were more likely to be of advanced maternal age ﹝(35.04±4.24)years vs (31.67±3.56)years, P=0.000﹞, higher pre-pregnancy body mass index ﹝(21.46± 3.69)kg/m2 vs (20.77±2.38)kg/m2, P=0.009﹞ and had lower amniotic fluid volume﹝(3.14±0.55)cm vs (3.38±0.55)cm, P=0. 001﹞ in 11-14 weeks ultrasound compared with twin pregnancies without fibroids. However, other parameters of fetal growths in early, middle and late pregnancy, neonatal conditions and obstetric outcomes had no statistical significance between twin pregnancies with fibroids and those without fibroids. Conclusion Fibroids’ effect on fetal growths and neonatal outcomes in twin pregnancies is not obvious. But twin pregnancy is a high risk factor for pregnancy and we should give more monitoring and management for twin pregnancy with fibroids, so that mothers and newborns get more reasonable and secure treatment.%目的:前瞻性评估子宫肌瘤对双胎胎儿生长发育及新生儿结局的影响。方法选取在首都医科大学附属北京妇产医院建档并于2013年6月至2014年12月分娩的双胎妊娠合并子宫肌瘤患者共46例作为研究组,以及双胎妊娠无肌瘤者63例作为对照组,观察并记录其孕早期、中期、晚期B超监测胎儿生长发育指标、新生儿出生情况及妊娠结局。结果与对照组相比,双胎妊娠合

  5. 膝关节类风湿关节炎伴重度屈曲畸形患者关节置换术后的中长期随访%Total knee arthroplasty for rheumatoid arthritis with severe knee flexion contracture: mid-long term follow-up study

    Institute of Scientific and Technical Information of China (English)

    周程沛; 周宗科; 沈彬; 杨静; 康鹏德; 裴福兴

    2012-01-01

    Objective To investigate the clinical outcomes of total knee arthroplasty (TKA) for severe knee flexion contracture of rheumatoid arthritis by a five-year follow-up, and explore the technique of TKA and rehabilitation after TKA. Methods From January 1998 to December 2005, 18 patients including 32 knees with rheumatoid arthritis with severe flexion contracture underwent primary bilateral TKA with soft tissue balancing. The average age was 38. 8 years (range, 35 -59 years). The course of disease was 7-30 years (14. 2 years in average). The flexion contracture had existed for 3-12 years (6. 5 years on average) . The preoperative flexion contracture angle was 67. 5° in average (60° - 85°) . The average motion range was 20. 3° (0° -35°). The HSS score was (21. 1 ± 13. 9). During the TKA procedure, based on the correct osteotomy, different methods of soft tissue balancing were used for different degrees of flexion contracture. The patients were followed up in 1, 2, 3, 6, 12 months after surgery and every year later on. The survival rate, range of motion and HSS score were evaluated during the follow-up. Results 10 patients including 18 knees were followed up from five to 10 years, and six patients including 11 knees were followed up for over 10 years after operation. The flexion deformity declined to 3. 7° (0° - 10°) , ROM were up to 103. 2° (90° - 120°) , and HSS scores was 81. 4. There was statistical difference between preoperative results and the reults of the latest follow - up (P < 0. 05) . One patient was replaced insert because of unstability on two years postoperation, and one patient was revisied because of loosening of femoral prosthesis in 9.4 years after operation. There was no infection or damage of lateral ligaments. Conclusions The soft tissue balancing and osteotomy of the distal femur are crucial procedures for TKA on patients of severe knee flexion contracture with rheumatoid arthritis. The rehabilitation training before and after operation can effectively improve the range of motion and the joint function.%目的 分析膝关节类风湿关节炎(RA)伴重度屈曲畸形行全膝关节置换术(TKA)中长期随访结果,探讨其关键的手术技术和康复措施.方法 1998年1月至2005年12月,18例RA伴重度屈曲畸形患者32膝行TKA,平均年龄38.8岁.RA病程14.2年,畸形时间6.5年;术前畸形67.5°,活动度20.3°,合并内翻畸形3例,外翻11例;术前股四头肌肌力3级7例,4级11例;HSS 评分21.1分.术前锻炼股四头肌肌力,术中软组织松解及增加截骨,术后伸直支具及伸膝锻炼.术后1、2、3、6、12个月及以后每年随访,评价关节活动度、生存率、HSS评分等.结果 16例患者获得随访,5~10年随访10例18膝,10年以上6例11膝.最后一次随访,膝关节屈曲畸形3.7°,活动度103.2°,HSS 评分为81.4分,与术前相比差异有统计学意义(P<0.05).2膝翻修,假体生存率93.1%.无感染及侧副韧带损伤.结论 通过加强术前术后股四头肌功能训练,术中软组织松解及增加股骨远端截骨,膝关节RA伴重度屈曲畸形患者TKA术后中长期随访效果满意.

  6. Embolização uterina para tratamento de miomas sintomáticos: impacto na qualidade de vida Uterine embolization for management of symptomatic fibroids: quality-of-life impact

    Directory of Open Access Journals (Sweden)

    Nestor Kisilevzky

    2007-10-01

    Full Text Available OBJETIVO: Verificar a mudança na qualidade de vida de pacientes portadoras de miomatose uterina sintomática submetidas a tratamento por embolização. MATERIAIS E MÉTODOS: Quarenta mulheres portadoras de miomatose uterina sintomática que foram tratadas com a técnica de embolização responderam a um questionário de qualidade de vida antes e 12 semanas após o procedimento. RESULTADOS: Verificou-se que o escore médio relacionado com a gravidade dos sintomas nas 40 pacientes antes da embolização foi de 62,07 ± 6,34 e se modificou, com significância estatística após o tratamento, quando se verificou escore médio de 20,42 ± 3,81. Da mesma forma, comprovou-se a melhora na qualidade de vida pela modificação dos escores antes e depois do tratamento, o que também apresentou significância estatística, passando de 40,26 ± 2,98 para 85,06 ± 2,57. CONCLUSÃO: A embolização uterina provoca alívio evidente dos sintomas relacionados com a miomatose e proporciona melhora substancial da qualidade de vida das pacientes.OBJECTIVE: To determine the impact on the quality of life in patients with symptomatic uterine fibroids submitted to uterine artery embolization. MATERIALS AND METHODS: Forty patients with symptomatic fibroids submitted to embolization have answered a quality-of-life questionnaire before and 12 weeks after the procedure. RESULTS: Mean score for symptoms severity before the procedure was 62.07 ± 6.34 and decreased with statistical significance to 20.42 ± 3.81 after the procedure. Similarly, scores for quality of life have improved from 40.26 ± 2.98 before the procedure to 85.06 ± 2.57 after the procedure, which again was statistically significant. CONCLUSION: Uterine embolization results in evident symptoms relief and significant improvement in the quality of life of patients with symptomatic fibroids.

  7. The clinical value of the special functions of DSA in interventional embolization for uterine fibroids%DSA特殊功能在子宫肌瘤栓塞治疗中的价值

    Institute of Scientific and Technical Information of China (English)

    何玉圣; 鲁东; 吕维富; 张劲松

    2009-01-01

    目的 评价DSA特殊功能在子宫肌瘤栓塞治疗中的价值.方法 46例子宫肌瘤栓塞中26例应用DSA特殊功能:3D-DSA、最佳工作体位、路图技术,20例采用常规DSA造影,对两种方法的对比剂用量、介入手术时间和透视时间进行比较和分析.结果 术中应用DSA特殊功能与常规DSA组比较,对比剂用量和透视时间明显减少(P0.05).结论 DSA特殊功能在子宫肌瘤栓塞中的应用能缩短手术时间,降低手术风险.可视化三维重建技术对介入手术操作具有重要指导意义.%Objective To evaluate the special functions of DSA in interventional embolization therapy for uterine fibroids. Methods The special functions of DSA, including 3D-DSA, the optimal working position and road-mapping technique, were utilized in performing interventional embolization therapy for uterine fibroids in twenty-six cases (experimental group). Routine DSA angiography was employed in twenty cases (control group). The volume of contrast media used, the time of completing the interventional procedure and the total fluoroscopic time in two groups were compared and the results were analyzed. Results The difference in the volume of contrast agent used and in the total fluoroscopic time between two groups was statistically significant (P 0.05). Conclusion In treating uterine fibroids with interventional embolization, the use of the special functions of DSA can reduce the manipulation time and lower the operation risk. Moreover, the technique of visible 3D reconstruction image is of great significance in guiding the procedure.

  8. B超在子宫肌瘤诊断中的应用价值分析%The Analysis of B Ultrasound Examination Value in Diagnosis of Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    赵波

    2015-01-01

    Objective Application value of B ultrasound examination in diagnosis of uterine fibroids is to be investigated. Methods Chose 45 patients with uterine fibroids received and treated in our hospital from August 2013 to August 2014 and separate them into X-ray examination group and B ultrasound examination group respectively and take patients’pathology result as the examination standard; and then observe and compare the diagnosis accuracy of X-ray examination and B ultrasound examination. Results The diagnosis accuracy rate of B ultrasound examination was up to 93.33%,while the diagnosis accuracy rate of X-ray examination was 77.78%; there was a diagnosis accuracy differential between two groups,and such a differential had statistic value(P<0.05). Conclusion B ultrasound examination is of high accuracy,besides,its operation is simple,economic,safe and non-invasive in diagnosis of uterine fibroids; therefore,it is quite worthwhile to be promoted.%目的:分析子宫肌瘤诊断中 B 超的应用价值。方法选取2013年8月~2014年8月间我院收治的子宫肌瘤患者45例,分为 X 线检查组与 B 超检查组,以病理结果作为检验标准,对比 B 超与 X 线检查的准确性。结果 B 超检查组诊断准确率(93.33%)高于 X 线检查组(77.78%),两组诊断准确率差异显著,有统计学意义(P<0.05)。结论子宫肌瘤应用 B 超诊断准确率高,操作简单,经济适用,安全无创。

  9. Analysis of prognosis of TCRM in the treatment of uterine fibroid complicated with infertility%TCRM 治疗子宫肌瘤伴不孕生殖预后分析

    Institute of Scientific and Technical Information of China (English)

    刘喻; 王明波; 李琼

    2015-01-01

    Objective To analyze pregnancy outcome by transcervical resection of myoma (TCRM) in the treatment of uterine fibroid complicated with infertility, in order to provide reference for optimal surgical plan. Methods There were 86 patients undergoing trans-laparoscopy myomectomy (TLM) as TLM group, and 72 patients undergoing TCRM for main treatment of uterine fibroid as TCRM+TLM group. All patients received follow-up for 6~36 months, and their postoperative pregnancy rate, and spontaneous abortion rate before and after operation were observed. Results The difference of cumulative pregnancy times and spontaneous abortion rate between the two groups had no statistical significance before operation (P>0.05). The difference of spontaneous abortion rate between the two groups before operation had statistical significance (P0.05). Conclusion TCRM in treating uterine fibroid complicated with infertility provides little uterine damage, with increased pregnancy rate and decreased spontaneous abortion rate. Its combination with TLM can provide assessment and treatment for pelvic cavity, and that is much better than single TLM treatment.%目的:分析宫腔镜子宫肌瘤电切术(TCRM)治疗子宫肌瘤伴不孕患者的妊娠结局,为制定最佳手术方案提供参考。方法86例采用腹腔镜子宫肌瘤剔除术(TLM)的患者作为 TLM 组,72例采用TCRM 治疗为主的子宫肌瘤伴不孕患者,设为 TCRM+TLM 组,所有患者均随访6~36个月,观察两组患者术后妊娠率、手术前后自然流产率。结果手术前两组累计妊娠次数与自然流产率比较,差异无统计学意义(P>0.05)。手术前后各组自然流产率比较,差异具有统计学意义(P0.05)。结论TCRM 治疗子宫肌瘤伴不孕对子宫的损伤较小,可明显增加妊娠率,降低自然流产率,与 TLM 共同进行可同时对盆腔情况予评估及治疗,明显优于单纯 TLM 治疗。

  10. 超声消融治疗子宫肌瘤的安全性及有效性%Study on the efficacy and safety of ultrasound ablation in treatment of uterine fibroids

    Institute of Scientific and Technical Information of China (English)

    陈文直; 令狐华; 陈锦云; 朱丽; 邓勇斌; 王智彪; 唐良萏; 杨武威; 张彦; 李静; 夏文秀; 周洁敏; 祝宝让; 赵纯全

    2010-01-01

    Objective To investigate the safety and efficacy of ultrasound ablation in treatment of uterine fibroids. Methods Ninety-nine patients with 117 leiomyomas in total treated by Haifu JC focused ultrasound tumor therapeutic system were enrolled in prospective and non-randomized clinical trial in First Affiliated Hospital of Chongqing Medical University and Academy of Military Medical Sciences. Ultrasound ablation was performed guided by real-time ultrasonography under conscious sedation for single session. All patients were followed up at 6 months after treatment. On the day of treatment and after 1 month, patients were given by magnetic resonance imaging(MRI) exam to evaluate the effect of fibroids ablation. At 3 and 6months after treatment, the ratio of ablated area and volume reduction of fibroids more than 50% were evaluated by MRI exam again. The symptoms improvements were evaluated by uterine fibroid symptom (UFS) and complications were analyzed by guideline of society of international radiation (SIR). Results The average ablated area ratio of the target fibroid was (76 ± 24)%. The average reduction in fibroid volume determined by MRI at 3 and 6 months after treatment was (45 ± 21)% and (59 ± 26)%. Which were significantly decreased than those before treatment (P < 0. 05). At 6 months after treatment, 84. 6% (99/117) of patients showed more than 50% volume reduction, the rate of improved symptom score was 92%(66/72). All patients could resume normal daily activities at 2 hours after treatment. The adverse reactions of SIR C - D included delayed hospitalization, repeat treatment and increased level of nursing. E - F included permanent sequelae and death. In this study, no adverse reactions of C - F were recorded. Common complications (SIR A- B, only observation or simple management without sequelae) were 35% (35/99).Four cases with adverse reactions B of SIR were found, including 2 cases with skin burning of degree Ⅱ and 2 cases with febrile, they were

  11. 选择性子宫动脉栓塞术对症状性子宫肌瘤的治疗作用%Effect of Selective Uterine Artery Embolization on Symptomatic Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    冯丽霞; 刘冬萍; 熊宁; 刘仙; 侯新民

    2011-01-01

    目的 观察选择性子宫动脉栓塞术(selective uterine artery embolization,SUAE)治疗症状性子宫肌瘸的疗效.方法 2007年2月~2009年6月,对34例症状性子宫肌瘤行选择性双侧子宫动脉栓塞术.肌壁间肌瘤31例,黏膜下肌瘤3例;单发29例,多发5例;肌瘤直径4 ~8.5 cm,平均5.3 cm.32例合并贫血,血红蛋白49 ~ 101 g/L.术前及术后3、6、12个月采用月经失血图(pictorial blood loss assessment chart,PBAC)评估月经量,检测血红蛋白值,B超测量子宫及肌瘤体积. 结果 栓塞成功率100%.3例黏膜下子宫肌瘤分别于术后31天、43天及52天坏死脱出宫颈外口,予以摘除.1例肌壁间肌瘤患者于术后10个月受孕.30例肌壁间肌瘤患者术后3个月月经量评分由术前162.4±22.6下降至87.8±13.4(t= 18.325,P=0.000),12个月降至34.3±10.8(t=25.380,P=0.000);血红蛋白术前为(76.5±11.7)g/L,术后6个月及12个月分别上升至( 103.7±7.3)g/L(t= 10.994,P=0.000),(109.5±5.8)g/L(t= 12.338,P=0.000);子宫及肌瘤体积自术后6个月显著逐渐缩小,子宫体积术前( 266.3±49.3) cm3,术后6个月缩小至( 175.6±53.4) cm3(t =9.047,P=0.000),12个月缩小至(135.3±44.2) cm3(t=11.036,P=0.000);肌瘤体积术前(101.5±23.4) cm3,术后6个月缩小至(54.1±16.7)cm3(t=9.888,P=0.000),12个月缩小至(35.6±11.5)cm3(t=14.119,P=0.000). 结论 SUAE能有效减少子宫肌瘤患者月经量,改善贫血,缩小子宫及肌瘤体积,且能保留女性生育能力,是治疗症状性子宫肌瘤安全、有效、微创的方法.%Objective To evaluate the efficacy of selective uterine artery embolization ( SUAE ) in the treatment of symptomatic uterine fibroids. Methods SUAE were performed on 34 patients with symptomatic uterine fibroids from Feburary 2007 to June 2009. There were 31 cases of intramural myoma and 3 cases of submucous myoma. Mono-myoma was found in 29 patients, and multi-myoma in 5 patients. The diameter of the fibroids was 4-8.5 cm with

  12. 腹腔镜和射频消融术治疗子宫肌瘤的临床观察%Clinical Observation of Laparoscopic Radiofrequency Ablation in Treatment of Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    初华

    2013-01-01

    Objective:Observed in patients with uterine fibroids be the clinical effect of radiofrequency catheter ablation by laparoscopic myomectomy.Methods:Were retrospectively analyzed the clinical data of patients of the hospital since November 2008 to November 2011, in the treatment of our department, 252 cases of uterine fibroids were randomly divided into AB two groups, each group of patients with 126 cases, group Aapplication of radiofrequency ablation, group B of laparoscopic myoma excluding surgery, the amount of contrast were observed intraoperative bleeding and the time of surgery and hospitalization time, be in the six months after the review B, the size of two groups of patients with endometriosisshape, and follow-up in two groups the fertility requirements of the patient's pregnancy.Results:Contrast AB two groups of patients with intraoperative blood loss was significantly different (P<0.05); AB, two sets of times for surgery in patients with contrast showed a significant difference (P<0.05).Group A were not hospitalized, only observed 2-4 hours from hospital after surgery, comparison of the AB, two groups of patients the hospital stay, was significantly different (P<0.05).Group B, 96 cases of childbearing, fertility in group A and 84 cases, 90 cases of pregnancy (93.75%) in group B within one year, 50 cases of pregnancy(59.52%) in group A within one year, compared with two groups was significant difference (P<0.05).Conclusion:Uterine fibroids in patients with LM and RF treatment were able to achieve the purpose of cure. Submucosal fibroids and intramural fibroids (convex to the uterine cavity) can reduce the patient's natural conception rate and embryo implantation rate (IVF), but the LM treatment in patients with pregnancy rate can improve, and effective, safe, minimally invasive should be used as fertility requirements of the patient's preferred; RF treatment time is shorter, not only less bleeding, and rapid postoperative recovery, while medical costs are

  13. 临床护理路径应用于子宫肌瘤妇女的满意度分析%Satisfaction analysis of clinical nursing pathway applied in women with uterine fibroids

    Institute of Scientific and Technical Information of China (English)

    江桂玲

    2014-01-01

    Objective To analyze and evaluate the satisfaction situation of the clinical nursing pathway applied in women with uterine fibroids. Methods 104 patients with uterine fibroids treated in our hospital from October 2011 to October 2012 were randomly divided into the observation group and the control group, with 52 patients in each group.Both groups received surgical treatment.The control group implemented conventional nursing measures and the observation group implemented clinical nursing pathway.The clinical nursing effects of the two groups of patients were analyzed comparatively. Results The observation group had shorter hospital stay and lower total hospitalization cost than the control group,with significant difference (P0.05).The observation group had higher nursing satisfaction degrees in the aspects of psychological support,technical level,health education,patient care and service attitude than the control group,with statistically significant differences between the two groups(P < 0.05 for all). Conclusion The implementation of clinical nursing pathway is conducive to enhancing the knowledge of patients with uterine fibroid, shortening hospital stay, reducing hospitalization cost,improving patient satisfaction to nursing services and enhancing nursing service quality.%目的:分析并评价临床护理路径应用于子宫肌瘤妇女的满意度情况。方法将我院自2011年10月~2012年10月期间收治的子宫肌瘤的患者104例随机分成观察组与对照组,每组各52例,均开展手术治疗,对照组实施常规护理措施,观察组实施临床护理路径,对比分析两组患者的临床护理效果。结果观察组的住院天数以及住院总花销均少于对照组,差异显著(P<0.05);观察组的健康教育知识达标率高于对照组,其并发症发生率低于对照组,两组比较差异均显著(P均<0.05);但两组治愈率相比无明显差异(P>0.05);观察组在心理支持、

  14. 缩宫素对超声消融治疗子宫肌瘤效果的影响%Effect of oxytocin on uterine fibroids treated by ultrasound ablation

    Institute of Scientific and Technical Information of China (English)

    黄秀; 何敏; 刘映江; 张炼; 王智彪

    2011-01-01

    目的 探讨缩宫素对超声消融治疗子宫肌瘤效果的影响.方法 采用MRI引导下的超声消融肿瘤治疗系统,以单点辐照的方式,选择确诊的26例子宫肌瘤患者的29个肌瘤中的82个靶点进行研究,比较使用缩宫素前、后辐照单点达到60℃时所需的能量、时间及升高单位温度(1℃)所需的能量.结果 使用缩宫素前,辐照单点温度达到60℃所需的能量为(5320±910)J,时间为(21±20)s,升高1 ℃所需的能量为(255±302)J;静脉滴注缩宫素后,辐照单点温度达到60℃所需的能量为(2890±325)J,时间为(12±7)s,升高1℃所需的能量为(126±94)J.使用缩宫素前、后,各指标间比较,差异均有统计学意义(P值分别为0.002、0.001、0.002).结论 缩宫素能明显降低超声消融治疗子宫肌瘤所需的能量,缩短治疗时间,从而提高治疗效率,具有很好的临床应用价值.%Objective To explore the effect of oxytocin on uterine fibroids treated by ultrasound ablation. Methods Eighty-two single points in 29 uterine fibroids from 26 patients were sonicated with magnetic resonance imaging guided by high intensity focused ultrasound before and after using oxytocin. The required total energy, sonication time required to reach 60 ℃ and the acoustic energy for increasing 1 ℃ of temperature at the single point before and after using oxytocin were compared. Results Before intravenous infusion of oxytocin, the average total sonication energy required to reach 60 ℃ was (5320 ±910) J and it took (21 ±20) seconds for sonicating a single point, the energy required for increasing 1 ℃ was (255 ± 302) J. In contrast, after intravenous infusion of oxytocin, the average total sonication energy required to reach 60 ℃ was (2890 ±325) J, and it took (12 ±7) seconds for sonicating a single point, the energy required for increasing 1 ℃ was ( 126 ± 94 ) J. Those three index all reached statistical difference ( P = 0.002, P = 0.001, P= 0

  15. Application Value of Clinical Pathway in Perioperative Nursing of Patients with Uterine Fibroids%临床路径在子宫肌瘤患者围术期护理中的应用价值

    Institute of Scientific and Technical Information of China (English)

    刘晓艳; 孙红运; 苗丽竺

    2016-01-01

    目的:探讨临床路径在子宫肌瘤患者围术期护理中的应用价值。方法选取2014年6月至2015年5月在大连市妇女儿童医疗中心接受手术治疗的84例子宫肌瘤患者为研究对象,按随机数字表法将其分为对照组和观察组,各42例。对照组患者给予围术期常规护理,观察组患者在对照组基础上实施临床护理路径,比较两组患者的术后恢复情况及护理满意度。结果观察组患者的肛门排气时间、住院时间均明显短于对照组,差异均有统计学意义(均P<0.05);观察组患者的护理满意度明显高于对照组,差异有统计学意义(P<0.05)。结论在子宫肌瘤患者围术期护理中应用临床路径,有助于促进患者康复进程,提升护理质量。%Objective To investigate the clinical path in the value of uterine fibroids in patients undergoing surgery of nursing.Methods From June 2014 to May 2015,84 cases of patients with uterine fibroids treated by surgical treatment of women and children's Medical Center in Dalian city were randomly divided into control group and experimental group by random number table method,42 cases in each group.The control group were treated with routine nursing,and the patients in the experimental group were treated with clinical nursing pathway on the basis of the control group.Compared with the two groups of patients, the postoperative recovery and nursing satisfaction were compared.Results The time of anus exhaust and hospital stay in the experimental group were significantly shorter than those in the control group,the difference was statisticaly significant(P<0.05),the nursing satisfaction of the experimental group was significantly higher than that of the control group,the difference was statisticaly significant (P<0.05).Conclusion The application of clinical pathway in perioperative nursing of patients with uterine fibroids is helpful to promote the rehabilitation process and improve

  16. 消化道炎性纤维性息肉14例临床病理分析%Inflammatory fibroid polyps in digestive tract:a clinical and pathological analysis of 14 cases

    Institute of Scientific and Technical Information of China (English)

    杨文婷; 林燕青; 曲利娟

    2015-01-01

    Purpose To investigate the clinical and pathological features of inflammatory fibroid polyps ( IFPs) and to discuss its diag-nosis, differential diagnosis and treatment. Methods Clinicopathological data of 14 cases of IFPs were collected and analyzed retro-spectively. Results Most of the 14 cases were found to have submucosal polyps of the digestive tract protruding growing into the cavi-ty. Perivascular onion skinning which formed by spindle fibrocytes around vascular proliferation and eosinophilic inflammatory infiltrates were present as the characteristic feature of lesions. ABC results demonstrated that the lesions showed fibroblastic, myofibroblastic and dendritic cell signs. Conclusions IFPs are rare, benign tumors that can arise throughout the digestive tract, with unique histological changes in pathology. Surgical excision or endoscopic removal is the main treatment.%目的:探讨消化道炎性纤维性息肉( inflammatory fibroid polyps, IFPs)的临床病理学特征、诊断、鉴别诊断及临床治疗。方法回顾性分析14例消化道IFPs的临床病理学特征并复习相关文献。结果14例IFPs中大体表现多为黏膜下息肉样或半球形隆起性肿物,光镜下以增生的梭形纤维细胞围绕血管形成“洋葱皮样”外观及间质较多嗜酸性粒细胞浸润为主要组织学特征,免疫组化标记肿瘤细胞表达纤维和肌纤维母细胞及树突细胞表型。结论 IFPs是消化道少见的良性间叶性肿瘤,具有独特的病理组织学改变,手术或内镜下肿物完整切除是主要的治疗方法。

  17. 人文关怀在妇科子宫肌瘤全切术患者中的应用%Application of humanistic care in nursing care of patients with uterine fibroids hysterectomy

    Institute of Scientific and Technical Information of China (English)

    叶燕珊; 肖俊英; 潘颖珊

    2015-01-01

    目的:探讨人文关怀在妇科子宫肌瘤全切患者中的应用效果。方法:选择我院2013年1~12月收治的子宫肌瘤手术患者80例患者为研究对象,随机等分为观察组和对照组,对照组术后实施常规护理,观察组在此基础上增加人文关怀,出院前比较两组患者的护理满意度及心理状态改善情况。结果:观察组的焦虑自评量表(SAS)和抑郁自评量表(SDS)评分明显低于对照组(P <0.05);观察组患者满意度明显高于对照组,差异有统计学意义(P <0.05)。结论:对子宫肌瘤全切术后患者实施细致的人文关怀,有助于消除患者不良情绪及满意度,提高生活质量。%Objective:To investigate the effect of the application of humanistic care in hysteromyoma patients with total resection .Methods:uterine fibroids surgery patients in our hospital from January to December in 2013 were 80 cases of patients as the research object,were randomly divided into the observation group and the control group,after surgery in the control group the implementation of routine care,the observation group in the control group on the basis of humanistic care increases, before discharge were compared between the two groups of nursing satisfaction and psychological state of improvement.Results:Self -rating anxiety scale(SAS) and Self -Rating Depression Scale(SDS) scores were significantly lower than the control group (P <0.05);satisfaction of observation group were significantly higher, the difference was statistically significant(P <0.05).Conclusion: of uterine fibroids resection were treated with humane care,help to eliminate the negative emotions of patients,improve customer satisfaction, and improve the quality of life.

  18. 58例腹腔镜手术与传统开腹手术剔除子宫肌瘤的临床对比%Clinical Comparison of 58 Cases of Laparoscopic Surgery and Conventional Open Surgery for Removing Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    闫利弘

    2014-01-01

    目的:探讨腹腔镜手术与传统开腹手术剔除子宫肌瘤的临床疗效。方法选取2012年8月-2013年3月在该院就诊的58例子宫肌瘤患者作为研究对象,随机分为实验组和对照组,回顾分析两组患者的临床疗效。结果观察组患者在术后住院、使用止痛药情况、排气以及术中出血轻快,都显著优于对照组,两组疗效效果差异有统计学意义(P<0.05)。结论腹腔镜手术治疗子宫肌瘤疗效显著,且并发症发生率低,具有广泛推广的临床价值。%Objective To investigate and compare the clinical efficacy of laparoscopic surgery and conventional open surgery for removing uterine fibroids. Methods 58 patients with uterine fibroids admitted in our hospital from August, 2012 to March, 2013 were selected as the subjects, and randomly divided into the experimental group and the control group. The clinical efficacy be-tween the two groups was analyzed retrospectively. Results The postoperative hospitalization, use of painkillers, exhaust and brisk bleeding of the patients in the observation group were significantly better than those of the control group, the differences between two groups in the effect were statistically significant (P<0.05). Conclusion Laparoscopic surgery is quite effective in the treatment of uterine fibroids with low complication rate and a value of wide promotion in clinical practice.

  19. Full-term pregnancy in umbilical hernia

    OpenAIRE

    2011-01-01

    While umbilical hernias frequently occur during pregnancy, the few reported cases of uterine or fibroid incarceration in ventral hernias during pregnancy all involved incisional abdominal wall defects from prior laparotomies and Cesarean sections; none involved umbilical hernias. We discuss the case of a 42-year-old well-developed, well-nourished grand multiparous woman (G8P7) with a huge umbilical hernia containing a 38-week gravid uterus, as well as her management and the avoidance of known...

  20. Comprehensive nursing care on the application of the pregnancy with uterine fibroids%综合化护理在妊娠合并子宫肌瘤中的应用

    Institute of Scientific and Technical Information of China (English)

    冯秀芬

    2017-01-01

    Objective: to summarize analysis with comprehensive nursing methods of pregnancy with hysteromyoma patients and their nursing effect.Methods: 120 cases of pregnancy with hysteromyoma patients as the research object, the control group of 60 cases of routine nursing care, observation group of 60 cases of integrated management, nursing effect were reviewed as well as the key indicators.Results: the disease control time, length of hospital stay, the nursing service satisfaction and incidence of complications such as indicators, obvious differences in group and the control group (P < 0.05), with statistical significance.Conclusion: pregnancy with uterine fibroids were treated by comprehensive care, help to improve the prognosis of patients, reduce complications and improve the quality of service, worthy of clinical popularization and application.%目的:总结分析妊娠合并子宫肌瘤患者应用综合化护理的方法及其护理效果.方法:以120例妊娠合并子宫肌瘤患者为研究对象,对照组60例常规护理,观察组60例综合化护理,回顾分析护理效果以及关键指标.结果:在疾病控制时间、住院时间、护理服务满意度以及并发症发生率等指标方面,观察组和对照组差异明显(P<0.05),具有统计学意义.结论:妊娠合并子宫肌瘤患者采用综合化护理,有助于改善患者预后,减少并发症的发生,提高服务质量,值得临床推广应用.

  1. Follow-ups of mid-term and long-term outcomes for uterine intramural myomas after percutaneous microwave ablation therapy%子宫肌壁间肌瘤经皮微波消融后中远期疗效观察

    Institute of Scientific and Technical Information of China (English)

    郝艳丽; 张晶; 韩治宇; 徐瑞芳; 马霞; 杨宇; 周洪雨; 葛海龙; 董雪娟

    2014-01-01

    Objective To evaluate the mid-term and long-term clinical outcomes for symptomatic intramural uterine myoma after ultrasound-guided percutaneous microwave ablation therapy (PMAT). Methods A total of 123 women with intramural uterine myoma underwent PMAT. Prospective studies were conducted to compare the dominant fibroid volume (FV), hemoglobin (HGB) and Uterine Fibroid Symptoms and Quality of Life Questionnaire (UFS-QOL) at baseline and 1, 2, 3 and 4 years of follow-up Results Comparing with the baseline, the shrinkage rate of FV at 1 year follow-up was 74.5%. HGB of anemic patients pre-PMAT increased from 91±11 to 114±20 g/L. Two parts of UFS-QOL symptoms severity scores (SSS) and health-related quality of life (HRQL) changed from 43±10 to 18±16 and 41±21 to 90±16 respectively at 1year follow-up. All four items stayed nearly the same at 2, 3 and 4 years post-therapy. Conclusion Ultrasound-guided PMAT of uterine fibroids can effectively ameliorate the mid-term and long-term clinical syndromes and improve quality of life by shrinking fibroids effectively or even disappearing completely.%目的 评价超声引导经皮微波消融(PMAT)治疗症状性子宫肌壁间肌瘤中远期临床疗效.方法 前瞻性研究解放军总医院2008年8月至2012年8月123例超声引导PMAT治疗的症状性子宫肌壁间肌瘤患者临床疗效.比较治疗前、治疗后1、2、3及4年肌瘤体积(FV),血红蛋白量(HGB),子宫肌瘤症状及与健康相关生活质量(UFS-QOL)评分.结果 治疗后1年,FV缩小74.5%;贫血患者HGB从(91±11) g/L上升至(114±20) g/L;UFS-QOL中子宫肌瘤症状评分(SSS)及与健康相关生活质量评分(HRQL)分别从43±10、41±21变化至18±16、90±16;治疗后2、3、4年4项参数均维持在治疗后1年时水平无明显变化.结论 超声引导PMAT子宫肌壁间肌瘤可使肌瘤有效缩小甚至完全消失,有效改善患者中远期临床症状,提高生活质量.

  2. Change and studies of ovarian function after uterine fibroids hysterectomy%子宫肌瘤子宫全切术后卵巢内分泌功能的变化与研究

    Institute of Scientific and Technical Information of China (English)

    汪川; 吴震溟

    2012-01-01

    目的 探讨子宫肌瘤子宫全切术后卵巢内分泌功能的变化情况.方法 选取2008年4月~2011年3月入住某院妇科并接受治疗的子宫肌瘤患者共66例,选取在其他科室就诊的无内分泌系统疾病,月经、子宫卵巢均正常,年龄结构相近的妇女20例为对照组.观察组所有患者均行常规B超、X光片以及探测宫腔检查,当确诊为子宫肌瘤,即行子宫全切术进行治疗.观察组在术前月经d5及术后1、3、7月,对照组在月经后d5进行FSH(促卵泡激素)、LH(黄体生成素)、PRL(催乳素)、E2(雌激素睾酮)等几种激素的免疫测定,同时对观察组术前及术后1、3、7月的卵巢衰退症状进行统计分析.结果 术前FSH(促卵泡激素)、LH(黄体生成素)、PRL(催乳素)3种激素水平与对照组相比不存在显著性差异,术后,各类激素水平均出现显著性升高,在术后7个月时测量值最高,E2的水平在术前术后均处于较高水平.观察组患者术后出现盗汗,脱发,阴道干涩等症状的几率显著增加,从术前的39.4%增加到术后7个月的69.7%.结论 行子宫切除术的患者在术后都不同程度地出现了卵巢衰退迹象,且FSH(促卵泡激素)、LH(黄体生成素)、PRL(催乳素)3种激素水平与术后时间基本呈现正相关关系.%OBJECTIVE To investigate the changes of ovarian function after total hysterectomy due to uterine fibroids. METHODS From April 2008 to March 2011, a total of 66 cases treated for uterine fibroids in our hospital were selected, 20 cases without endocrine system diseases in the other sections, whose menstruation, ovary and uterus were normal, age structure was similar in the control group. All patients in the observation group underwent conventional B-ultrasound, X-rays, and the detection of uterine examination, the cases of ultimate diagnosed uterine fibroid were conducted on hysterectomy for treatment. In observation group, the preoperative 5th day and

  3. Uterine leiomyomas/fibroids are the most common pelvic tumors of the female genital tract. Transforming growth factor beta (TGF β family members are multi-functional cytokines that play a key role in cellular growth, proliferation and differentiation. The aim of this study was to investigate whether TGF β1 - 509 C/T polymorphism could be used as a susceptibility marker in Uterine fibroids pathogenesis. ARMS PCR was carried out for controls and patients (n=103 to identify the specific genotypes. Genotypes and allelic frequencies in both groups were compared. Proportions of C homozygote, heterozygote and T homozygote for TGF β1gene polymorphisms were 37.9%, 44.7%, 17.5% in the control individuals and 37%, 51.5%, 11.7% in the uterine fibroid patients. There was no significant difference between the controls and the patients thus indicating the tumor suppressor effect of TGF β1 in the early stages of tumor pathogenesis. The study was found to be in association with the earlier reported data wherein TGF β1 acts as tumor suppressor in the early stages and as a tumor promoter in the later stages of tumor pathogenesis

    Directory of Open Access Journals (Sweden)

    M.Veronica

    2013-06-01

    Full Text Available Uterine leiomyomas/fibroids are the most common pelvic tumors of the female genital tract. Transforming growth factor beta (TGF β family members are multi-functional cytokines that play a key role in cellular growth, proliferation and differentiation. The aim of this study was to investigate whether TGF β1 - 509 C/T polymorphism could be used as a susceptibility marker in Uterine fibroids pathogenesis. ARMS PCR was carried out for controls and patients (n=103 to identify the specific genotypes. Genotypes and allelic frequencies in both groups were compared. Proportions of C homozygote, heterozygote and T homozygote for TGF β1gene polymorphisms were 37.9%, 44.7%, 17.5% in the control individuals and 37%, 51.5%, 11.7% in the uterine fibroid patients. There was no significant difference between the controls and the patients thus indicating the tumor suppressor effect of TGF β1 in the early stages of tumor pathogenesis. The study was found to be in association with the earlier reported data wherein TGF β1 acts as tumor suppressor in the early stages and as a tumor promoter in the later stages of tumor pathogenesis

  4. Common Terms

    Science.gov (United States)

    ... Print Page Text Size: A A A Listen Common Terms Below is a list of diabetes-related ... a skin condition characterized by darkened skin patches; common in people whose body is not responding correctly ...

  5. Gravidez e parto após embolização arterial para tratamento de leiomioma uterino Pregnancy and delivery after arterial embolization for fibroid treatment

    Directory of Open Access Journals (Sweden)

    Cláudio Emilio Bonduki

    2006-10-01

    with significant reduction in the uterus and myoma volumes. Four of them got pregnant, two had an early abortion and two evolved normally till the end of gestation with a term delivery. One of these had twins. CONCLUSION: Embolization of the uterine arteries is an option for the treatment of uterine myoma, and presents good clinical and anatomical results, allowing patients to preserve their reproductive capacity.

  6. A rare case of term viable secondary abdominal pregnancy following rupture of a rudimentary horn: a case report

    Directory of Open Access Journals (Sweden)

    Amritha Bhandary

    2009-01-01

    Full Text Available Abstract Introduction Abdominal pregnancy is a rare event, but one that represents a grave risk to the health of the pregnant woman. An abdominal pregnancy is defined as an ectopic pregnancy that implants in the peritoneal cavity. Early abdominal pregnancy is self-limited by hemorrhage from trophoblastic invasion with complete abortion of the gestational sac that leaves a discrete crater. Advanced abdominal pregnancy is a rare event, with high fetal and maternal morbidity and mortality. Case presentation This is a case report of a 22-year-old primigravida with an abdominal pregnancy from a ruptured rudimentary horn. She was diagnosed as a case of term pregnancy with placenta previa with a transverse fetal lie and cervical fibroid and was prepared for an elective cesarean section. Intra-operatively, a live term female baby was extracted from the peritoneal cavity and it turned out to be an abdominal pregnancy from a ruptured rudimentary horn of a unicornuate uterus, which is a very rare condition. Mother and baby were in good condition after such a catastrophic event. Conclusion This case illustrates a rare obstetric condition which can be a severe catastrophic condition leading to maternal mortality and morbidity. It is imperative for every obstetrician to have in mind the possibility of abdominal pregnancy, although rare, especially in pregnant patients with persistent abdominal pain and painful fetal movements.

  7. Mid- to long-term outcome comparison of the Medtronic Hancock II and bi-leaflet mechanical aortic valve replacement in patients younger than 60 years of age: a propensity-matched analysis.

    Science.gov (United States)

    Wang, Yin; Chen, Si; Shi, Jiawei; Li, Geng; Dong, Nianguo

    2016-03-01

    This study aims to compare mid-long-term clinical outcomes between patients younger than 60 years of age undergoing bioprosthetic and mechanical aortic valve replacement. From January 2002 to December 2009, patients younger than 60 years of age who received Medtronic Hancock II porcine bioprostheses were selected and compared with those who received mechanical bi-leaflet valves in the aortic position. A stepwise logistic regression propensity score identified a subset of 112 evenly matched patient-pairs. Mid-long-term outcomes of survival, valve-related reoperations, thromboembolic events and bleeding events were assessed. The follow-up was only 95.1% complete. Fourteen measurable variables were statistically similar for the matched cohort. Postoperative in-hospital mortality was 3.6% (bioprosthetic valves) and 2.7% (mechanical valves) (P = 0.700). Survival at 5 and 10 years was 96.3 and 88.7% for patients receiving bioprosthetic valve replacement versus 96.3 and 87.9% for patients receiving mechanical valve replacement (P = 0.860), respectively. At 5 and 10 years after operations, freedom from valve-related reoperation was 97.2 and 94.8% for patients receiving mechanical valve replacement, and 96.3 and 90.2% for patients receiving bioprosthetic valve replacement (P = 0.296), respectively. There was no difference between freedom from thromboembolic events (P = 0.528) and bleeding events (P = 0.128) between the matched groups during the postoperative 10 years. In patients younger than 60 years of age undergoing aortic valve replacement, mid-long-term survival rate was similar for patients receiving bioprosthetic versus mechanical valve replacement. Bioprosthetic valves were associated with a trend for a lower risk of anticoagulation treatment and did not have significantly greater likelihood of a reoperation. These findings suggest that a bioprosthetic valve may be a reasonable choice for AVR in patients younger than 60 years of age. © The Author 2015. Published by

  8. Term Graph Rewriting and Parallel Term Rewriting

    CERN Document Server

    Corradini, Andrea; 10.4204/EPTCS.48.3

    2011-01-01

    The relationship between Term Graph Rewriting and Term Rewriting is well understood: a single term graph reduction may correspond to several term reductions, due to sharing. It is also known that if term graphs are allowed to contain cycles, then one term graph reduction may correspond to infinitely many term reductions. We stress that this fact can be interpreted in two ways. According to the "sequential interpretation", a term graph reduction corresponds to an infinite sequence of term reductions, as formalized by Kennaway et.al. using strongly converging derivations over the complete metric space of infinite terms. Instead according to the "parallel interpretation" a term graph reduction corresponds to the parallel reduction of an infinite set of redexes in a rational term. We formalize the latter notion by exploiting the complete partial order of infinite and possibly partial terms, and we stress that this interpretation allows to explain the result of reducing circular redexes in several approaches to te...

  9. Clinical Study on Treatment for Uterine Fibroids with Intratumoral Injection of Methotrexate Com-bined with Levonorgestrel%甲氨蝶呤瘤体内注射联合左炔诺孕酮治疗子宫肌瘤的临床研究

    Institute of Scientific and Technical Information of China (English)

    董梅

    2015-01-01

    Objective To explore the efficacy and safety of intratumoral injection of methotrexate com-bined with levonorgestrel in treating uterine fibroids .Methods A total of 186 patients with uterine fibroids who were treated in Zoucheng People′s Hospital from Jan.2011 to Jan.2012 were selected and divided into combination group(n=92) and control group(n=94) according to random number table.Patients in combi-nation group were treated with intratumoral injection of methotrexate (50-60 mg) combined with levonorg-estrel(20 μg).While patients in control group were only treated with levonorgestrel(20 μg).Improvement of clinical symptomschanges of uterine fibroids volume,efficiency,incidences of adverse reactions were com-pared between the two groups.Results After treatment,the menstrual recovery rate,disappearance rate of lower abdomen and waist pain, disappearance rate of frequent and urgent micturition in combination group were significantly higher than those in control group (P<0.05).Six months,twelve months after treatment, the uterine myoma volumes of the combination group were significantly smaller than those of the control group [(43.7 ±18.3) cm3 vs (49.2 ±18.0) cm3,(30.4 ±17.0) cm3 vs (42.5 ±16.5) cm3,P<0.05].The efficiency of the combination group was higher than that of the control group(94.6% vs 85.1%,P<0.05). Adverse reactions occurred 1-3 days after injection of methotrexate in the combination group were mild and recovered rapidly,while no obvious adverse reaction occurred in the control group.Conclusion Treating uterine fibroids with levonorgestrel release system combined with intratumoral injection of methotrexate can reduce uterine fibroids volume and improve clinical symptoms more quickly,with better curative effect,com-pared with simple treatment with levonorgestrel release system.%目的:探讨甲氨蝶呤瘤体内注射联合左炔诺孕酮治疗子宫肌瘤的疗效及安全性。方法选择2011年1月至2012年1月于邹城市人民医院妇科

  10. [Long-term use of combined hormonal contraception--myths and reality].

    Science.gov (United States)

    Novotná, M; Huvar, I; Bláha, O

    2002-09-01

    To assess relationship of long-term use of combined oral contraception (COC) and women health, discussion about myths connected with use of COC. Review of literature. Department of Obstetrics and Gynaecology, Hospital of Merciful Brothers, Brno, Czech Republic. Identification of studies able to address the topic using Medline database search. Besides reliable control of fertility COC protect women against dysmenorrhea, iron deficiency anemia, ovarian cysts and uterine fibroids. COC plays very important role in gynecologic endocrinology suppressing effectively hyperandrogenism, which has not only cosmetic effect but brings also improvement in cardiovascular health of affected perimenopausal women. Premenopausal using of COC could help preserve bone mineral density and can reduce the risk of developing Alzheimer's disease. The most important feature is protective effect against endometrial (by 70%) and ovarian (by 50%) cancer which increases with duration of COC use and is long lasting and may be observed 15 to 20 years after stopping use. Association of use COC with increased risk neither of cervical cancer nor breast cancer has not been confirmed. Controversy still persists over the association of long-term (longer than 8 years) COC use by young nulliparas and breast cancer. The risk in this group of users is probably slightly increased. But no authorities recommended any restriction of COC's prescription. Some studies have suggested an inverse relationship between use of COC and risk of colorectal cancer. The only established evidence of direct association between OC use and cancer risk is the increased risk for hepatocellular carcinoma in the absence of hepatitis B (but maximum by 4 cases per 1,000,000 users per year). Most non-contraceptive health benefits of COC are still not widely appreciated in spite of much evidence. The final decision of contraception method is upon well and adequate informed user by well educated doctor.

  11. 子宫动脉栓塞联合宫腔镜治疗巨大子宫黏膜下肌瘤临床分析%Uterine artery embolization combined with hysteroscopy in treatment of gigantic submucosal fibroids of uterus

    Institute of Scientific and Technical Information of China (English)

    都君君

    2015-01-01

    目的 探讨对巨大子宫黏膜下肌瘤行子宫动脉栓塞联合宫腔镜治疗的临床效果.方法 随机选取本院2013年8月至2014年3月期间收治的巨大子宫黏膜下肌瘤患者64例,按照治疗方案的不同将其分为观察组和对照组.其中对照组患者行宫腔镜电切术,观察组患者则采用子宫动脉栓塞联合宫腔镜进行治疗,对两组患者的临床治疗效果及其并发症的发生情况进行观察对比.结果 观察组患者的手术治疗总有效率为96.88%,明显高于对照组患者(40.63%);观察组患者术后并发症的发生率为12.50%,明显低于对照组患者(40.63%);差异具有统计学意义(P<0.05).结论 采用子宫动脉栓塞联合宫腔镜治疗巨大子宫黏膜下肌瘤,效果显著,有助于彻底清除肌瘤组织,促进患者术后恢复,建议在临床上进一步推广.%Objective To investigate the clinical effect of uterine artery embolization combined with hysteroscopy in the treatment of gigantic submucosal fibroids of uterus.Methods 64 patients with gigantic submucosal fibroids of uterus admitted in our hospital from August 2013 to March 2014 were randomly selected and were divided into an observation group and a control group according to different treatment regimens.The control group was treated with hysteroscopic surgery and the observation group with uterine artery embolization and hysteroscopy.The clinical therapeutic effect and the incidence of relevant complication in both groups were observed and compared.Results The total effective rate of the surgical treatment of the observation group was 96.88%, which was significantly higher than that of the control group (40.63%);the incidence of postoperative complications of the observation group was 12.50%, which was significantly lower than that of the control group (40.63%);the differences were statistically significant (P<0.05).Conclusions Uterine artery embolization combined with hysteroscopy in the

  12. 植物性雌激素对子宫肌瘤合并缺铁性贫血患者血清激素水平、NOS及氧化应激产物影响%Effect of plant estrogen on serum hormone levels, NOS and oxidative stress products in patients with uterine fibroids with iron deficiency anemia

    Institute of Scientific and Technical Information of China (English)

    胡艳萍; 李璐; 李馨

    2015-01-01

    Objective To investigate the effect of plant estrogen on serum hormone levels, NOS and oxidative stress products in patients with uterine fibroids with iron deficiency anemia.Methods 80 cases of hysteromyoma patientswith uterine fibroids with iron deficiency anemia were selected, according to the different medication were randomly divided into experiment group and control group,40 cases in each group.Two groups were treated with anemia correction , mifepristone oral ,and the experiment group were treated on the base of the control group with plant estrogen, 12 weeks for a course.serum sex hormone, NOS, SOD and MDA level were detected.ResuIts Compared with the control group, the indexes of patients in the experimental group were lower(P<0.05), level of serum NOS were higher(P<0.05), level of serum SOD were higher(P<0.05), level of serum MDA were lower ( P<0.05 ) .ConcIusion Plant estrogen can improve the serum levels of serum hormone, NOS and oxidative stress levels of the treatment of uterine fibroids, worthy of clinical promotion.%目的:探讨植物性雌激素对子宫肌瘤合并缺铁性贫血患者血清激素水平、NOS及氧化应激产物的影响。方法收集子宫肌瘤患者80例,根据用药不同随机分为实验组和对照组,每组各40例,2组患者给与贫血纠正治疗,对照组给与米非司酮口服,实验组在对照组基础上给与植物性雌激素治疗,连续12周后对患者的血清性激素、NOS、SOD、MDA水平进行检测。结果治疗后,与对照组相比,实验组血清性激素各指标均较低(P<0.05),血清NOS水平较高(P<0.05),血清SOD水平较高(P<0.05),MDA水平较低( P<0.05)。结论植物性雌激素能够通过改善患者血清激素水平、NOS及氧化应激产物水平治疗子宫肌瘤,对临床具有指导意义。

  13. Term Graph Rewriting and Parallel Term Rewriting

    Directory of Open Access Journals (Sweden)

    Andrea Corradini

    2011-02-01

    Full Text Available The relationship between Term Graph Rewriting and Term Rewriting is well understood: a single term graph reduction may correspond to several term reductions, due to sharing. It is also known that if term graphs are allowed to contain cycles, then one term graph reduction may correspond to infinitely many term reductions. We stress that this fact can be interpreted in two ways. According to the "sequential interpretation", a term graph reduction corresponds to an infinite sequence of term reductions, as formalized by Kennaway et.al. using strongly converging derivations over the complete metric space of infinite terms. Instead according to the "parallel interpretation" a term graph reduction corresponds to the parallel reduction of an infinite set of redexes in a rational term. We formalize the latter notion by exploiting the complete partial order of infinite and possibly partial terms, and we stress that this interpretation allows to explain the result of reducing circular redexes in several approaches to term graph rewriting.

  14. [Cesarean section incidence and vaginal birth success rate at term pregnancy after myomectomy].

    Science.gov (United States)

    Mekiňová, L; Janků, P; Filipinská, E; Kadlecová, J; Ventruba, P

    To compare the incidence of primary and acute cesarean section (CS) and to compare success rate of vaginal delivery. To determine the frequency of maternal complications and evaluation of post-partum condition of the newborn. Prospective, pilot, cohort study. Department of Gynecology and Obstetrics Masaryk University and University Hospital Brno. Analysis of patients with physiologically ongoing singleton pregnancy and term delivery, vertex presentation. Women from the study group (n = 67) underwent myomectomy because of symptomatic, solitary uterine fibroid. Women from the control group (n = 4079) had no history of myomectomy. Analysis was aimed at comparing the incidence of primary and acute CS and comparing success rate of vaginal delivery in both groups and determing the frequency of maternal complications and evaluation of post-partum condition of the newborn. A significantly higher incidence of primary cesarean section was observed in the study group with a history of myomectomy compared to the control group (n = 20, 29.9%; versus n = 396, 9.7 %, p cesarean section in both groups was recorded (n = 7, 10.4%; versus n = 570, 14.0%, p = 0.079). No statistically significant difference in the success of vaginal delivery in both groups was recorded (n = 40, 85.1%; versus n = 3113, 84.5%, p = 0.079). The excessive blood loss was the most frequent complication in both group (n = 9, 13.4%; versus n = 214, 5.2%, p = 0.057). No statistically significant difference in the incidence of uterine rupture and postpartum hysterectomy was recorded. No maternal or fetal death related to childbirth was observed. The history of myomectomy does not increase the incidence of acute cesarean section in the group of strictly selected patients suitable for vaginal birth and has no impact on the success of vaginal delivery. Careful management of labor is a prerequisite for a low risk of maternal complications and good perinatal outcomes.

  15. Full-term pregnancy in umbilical hernia

    Directory of Open Access Journals (Sweden)

    Damien Punguyire

    2011-01-01

    Full Text Available While umbilical hernias frequently occur during pregnancy, the few reported cases of uterine or fibroid incarceration in ventral hernias during pregnancy all involved incisional abdominal wall defects from prior laparotomies and Cesarean sections; none involved umbilical hernias. We discuss the case of a 42-year-old well-developed, well-nourished grand multiparous woman (G8P7 with a huge umbilical hernia containing a 38-week gravid uterus, as well as her management and the avoidance of known complications that have occurred in similar incisional hernia cases. Successful pregnancy outcomes can occur in cases of pregnancies in ventral hernias, even in resource-poor settings that have Cesarean section capabilities

  16. Clinical Observation on Treatment of Uterine Fibroid Artery Embolization Induced Postoperative Syndrome by Therapy of Promoting Blood Circulation and Removing Stasis in Patients with Uterus Myoma%化瘀散结法治疗子宫肌瘤动脉栓塞术后综合征的临床观察

    Institute of Scientific and Technical Information of China (English)

    冷观群; 亢雪峰; 魏毅利; 邱永秀

    2010-01-01

    目的 观察化瘀散结法治疗子宫肌瘤患者行子宫动脉栓塞术(uterine fibroid artery embolization,UFAE)后并发症的近期临床疗效.方法 将60例瘀阻胞宫证子宫肌瘤患者随机分为治疗组和对照组各30例,两组均采用Sldinger技术完成UFAE治疗.治疗组在术后3个月服用活血化瘀、散结消癥类中药,对照组酌情予对症治疗.两组患者均术后随访6个月,详细观察并记录患者治疗前后月经变化,栓塞综合征出现的时间、程度、缓解方法及消失时间.结果 两组术后均未发现闭经;对照组出现1例轻度泌尿生殖系统感染,治疗组无泌尿生殖系统感染;治疗组发生盆腔疼痛的病例数显著低于对照组;治疗组盆腔疼痛评分、持续时间和阴道不规则流血持续时间显著低于对照组(P<0.05).结论 化瘀散结法治疗UFAE并发症具有明显优势,不良反应少,临床具有较好的应用前景.

  17. The Effect of Mifepristone on the SULT1E1 in Uterine Fibroid Tissue,ERαand ERβProtein Levels%米非司酮对子宫肌瘤组织SULT1 E1和雌激素受体α、β受体蛋白的影响

    Institute of Scientific and Technical Information of China (English)

    高玲; 李红霞

    2016-01-01

    Objective To evaluate the effect of mifepristone on the uterine fibroid tissue sulfotransferases 1E1 (SULT1E1), estrogen receptorα(ERα) and ERβprotein levels.Methods Total of 110 patients with uterine fibroid tissue in People′s Hospital of Chongqing Dadukou District from Oct.2013 to Apr.2015 were included.According to the random number table method they were divided into an observation group and a control group,55 cases each.The control group given preoperative oral placebo after a routine clinical exami-nation,taking 90 consecutive surgery treatment in the future.Observation group on the basis of preoperative routine clinical examination joint treated with mifepristone ,the first day of menstruation in patients with oral mifepristone 12.5 mg,taking 90 consecutive surgery in the future.Changes in the two groups before and after treatment were compared with tumor volume level,SULT1E1 content, ERα, ERβintegration level changes and therapeutic effect of the two groups were compared .Results Total effective rate of the observation group was higher than the control group[83.64%(46/55) vs 45.45%(25/55)], the difference was statistically significant( P <0.05 );after treatment, tumor volume of the observation group was lower than the control group[(96.32 ±4.65) mm3 vs (132.58 ±4.64) mm3],the difference was statistically significant(P<0.01);SULT1E1,ERα, ERβof the observation group were lower than the control group [(28.24 ± 3.47)% vs (33.67 ±3.92)%,(0.32 ±0.05)% vs (0.58 ±0.04)%,(0.09 ±0.01)% vs (0.12 ± 0.01)%],the differences were statistically significant(P <0.01).Conclusion Mifepristone has good effect for uterine fibroid patient,which can reduce tumor size, lower SULT1E1 and ERα, ERβlevel, with significantly improved efficacy,thus is worthy of promotion in clinical.%目的:探讨米非司酮对子宫肌瘤组织雌激素硫酸转移酶(SULT1E1)、雌激素受体(ER)α和ERβ蛋白的影响。方法选择2013年10月至2015年4月重庆市

  18. Glossary of Terms

    Science.gov (United States)

    ... Terms Glossary of Terms Profession of Medicine The art and science of maintaining health; recognizing, understanding, preventing, ... accredited school of medicine or osteopathy Note: The definition of physician in federal law is sometimes used ...

  19. Bisimilarity of Open Terms

    NARCIS (Netherlands)

    Rensink, Arend; Palamidessi, C.; Parrow, J.

    1997-01-01

    The standard way of lifting a binary relation, R, from closed terms of an algebra to open terms is to define its closed-instance extension, R_{ci}, which holds for a given pair of open terms if and only if R holds for all their closed instantiations. In this paper, we study alternatives for the case

  20. RxTerms

    Data.gov (United States)

    U.S. Department of Health & Human Services — RxTerms is a drug interface terminology derived from RxNorm for prescription writing or medication history recording (e.g. in e-prescribing systems, PHRs). RxTerms...

  1. Dictionary of Marketing Terms.

    Science.gov (United States)

    Everhardt, Richard M.

    A listing of words and definitions compiled from more than 10 college and high school textbooks are presented in this dictionary of marketing terms. Over 1,200 entries of terms used in retailing, wholesaling, economics, and investments are included. This dictionary was designed to aid both instructors and students to better understand the…

  2. Interpreting uncertainty terms.

    Science.gov (United States)

    Holtgraves, Thomas

    2014-08-01

    Uncertainty terms (e.g., some, possible, good, etc.) are words that do not have a fixed referent and hence are relatively ambiguous. A model is proposed that specifies how, from the hearer's perspective, recognition of facework as a potential motive for the use of an uncertainty term results in a calibration of the intended meaning of that term. Four experiments are reported that examine the impact of face threat, and the variables that affect it (e.g., power), on the manner in which a variety of uncertainty terms (probability terms, quantifiers, frequency terms, etc.) are interpreted. Overall, the results demonstrate that increased face threat in a situation will result in a more negative interpretation of an utterance containing an uncertainty term. That the interpretation of so many different types of uncertainty terms is affected in the same way suggests the operation of a fundamental principle of language use, one with important implications for the communication of risk, subjective experience, and so on.

  3. Dynamic term structure models

    DEFF Research Database (Denmark)

    Andreasen, Martin Møller; Meldrum, Andrew

    This paper studies whether dynamic term structure models for US nominal bond yields should enforce the zero lower bound by a quadratic policy rate or a shadow rate specification. We address the question by estimating quadratic term structure models (QTSMs) and shadow rate models with at most four...

  4. Astrophysical terms in Armenian

    Science.gov (United States)

    Yeghikian, A. G.

    2015-07-01

    There are quite a few astrophysical textbooks (to say nothing about monographs) in Armenian, which are, however out of date and miss all the modern terms concerning space sciences. Many terms have been earlier adopted from English and, especially, from Russian. On the other hand, teachers and lecturers in Armenia need scientific terms in Armenian adequately reproducing either their means when translating from other languages or (why not) creating new ones. In short, a permanently updated astrophysical glossary is needed to serve as explanation of such terms. I am not going here to present the ready-made glossary (which should be a task for a joint efforts of many professionals) but instead just would like to describe some ambiguous examples with comments where possible coming from my long-year teaching, lecturing and professional experience. A probable connection between "iron" in Armenian as concerned to its origin is also discussed.

  5. Long-term collections

    CERN Multimedia

    Collectes à long terme

    2007-01-01

    The Committee of the Long Term Collections (CLT) asks for your attention for the following message from a young Peruvian scientist, following the earthquake which devastated part of her country a month ago.

  6. D-term strings

    CERN Document Server

    Dvali, Gia; Van Proeyen, A; Dvali, Gia; Van Proeyen, Antoine

    2004-01-01

    We study the embedding of cosmic strings, related to the Abrikosov-Nielsen-Olesen vortex solution, into d=4, N=1 supergravity. We find that the local cosmic string solution which saturates the BPS bound of supergravity with the D-term potential for the Higgs field and with the constant Fayet--Iliopoulos term, has 1/2 of supersymmetry unbroken. We observe an interesting relation between the gravitino supersymmetry transformation, positive energy condition and the deficit angle of the cosmic string. We argue that the string solutions with the magnetic flux with F-term potential cannot be supersymmetric, which leads us to a conjecture that D1-strings of string theory in the effective 4d supergravity may be described by the D-term strings, which we study in this paper.

  7. Index of Glossary Terms

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? Index of Glossary Terms Share this page: Was this ... Serum Serum Sickness Shock Shwachman-Diamond Syndrome Sideroblastic Anemia Sigmoidoscopy Sign Somatic Cells Specificity Spina bifida Spirochete ...

  8. Plagiarism (Coming to Terms).

    Science.gov (United States)

    Bowden, Darsie

    1996-01-01

    Explores the origins of the word "plagiarism" and concepts of authorship. Examines a number of current issues concerning plagiarism, for instance, how the term complicates teacher-student relationships and peer cooperation in writing. (TB)

  9. Understanding anatomical terms.

    Science.gov (United States)

    Mehta, L A; Natrajan, M; Kothari, M L

    1996-01-01

    Words are our masters and words are our slaves, all depending on how we use them. The whole of medical science owes its origin to Greco-Roman culture and is replete with terms whose high sound is not necessarily accompanied by sound meaning. This is even more the case in the initial, pre-clinical years. Anatomical terminology seems bewildering to the initiate; and maybe that is a reason why love of anatomy as a subject does not always spill over through later years. Employing certain classifications of the origin of the anatomical terms, we have prepared an anthology that we hope will ease the student's task and also heighten the student's appreciation of the new terms. This centers on revealing the Kiplingian "how, why, when, where, what, and who" of a given term. This presentation should empower students to independently formulate a wide network of correlations once they understand a particular term. The article thus hopes to stimulate students' analytic and synthetic faculties as well. A small effort can reap large rewards in terms of enjoyment of the study of anatomy and the related subjects of histology, embryology, and genetics. It is helpful to teachers and students alike. This exercise in semantics and etymology does not demand of the student or his teacher any background in linguistics, grammar, Greek, Latin, Sanskrit, anatomy, or medicine.

  10. Estratégias para redução da exposição de radiação ionizante em mulheres submetidas à embolização de miomas uterinos Strategies for reduction of exposure to ionizing radiation in women undergone to uterine fibroid embolization

    Directory of Open Access Journals (Sweden)

    Breno Boueri Affonso

    2010-02-01

    the ovaries and the skin of patients undergoing uterine fibroid embolization (UFE, and to suggest a radiologic protocol directed at reducing the risks involved in this procedure. METHODS: seventy-three consecutive women (mean age: 27 years participating in an institutional research protocol, having symptomatic uterine fibroids with indication for minimally invasive treatment, underwent UFE. We estimated the radiation absorbed by the ovaries by means of vaginal dosimeters and the radiation dose absorbed by the skin by means of indirect calculations of radiation absorption. The first 49 patients belonged to the Pre-modification Group, and the last 24, to the Post-modification Group. The second group received a modified protocol of X-ray imaging, with a reduction by half of the frames number per second during arteriography, in an attempt to match the values obtained to those of the literature, and avoiding as much as possible unnecessary exposure to the X-ray beam. RESULTS: there were no technical complications in any of the procedures performed. There were no differences in the mean fluoroscopy time or in the mean number of arteriographies between the two groups. We obtained a 57% reduction in the estimated absorbed ovarian dose between groups (29.0 versus 12.3 cGy and a 30% reduction in the estimated dose absorbed by the skin (403.6 versus 283.8 cGy. CONCLUSIONS: a significant reduction in the absorption of radiation in patients undergoing UFE can be achieved by changing the number of frames per second in angiographic series, and by the routine use of radiological protection standards.

  11. 帕瑞昔布钠超前镇痛对子宫肌瘤患者术后镇痛效果及细胞免疫功能的影响%Effect of Parecoxib Sodium Preemptive Analgesia on Postoperative Analgesia and Cellular Immune Function in Patients with Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    李明勇; 王倩青

    2014-01-01

    目的:探讨帕瑞昔布钠超前镇痛对子宫肌瘤患者术后镇痛效果以及细胞免疫功能的影响。方法选取2011年3月至2014年4月择期行子宫肌瘤切除术患者116例,随机分为超前组(n=58)和对照组(n=58),麻醉前30 min ,超前组采用40 mg帕瑞昔布钠进行静脉注射,对照组采用5 mL生理盐水进行静脉注射。利用视觉模拟评分法(VAS法)对两组患者术后疼痛情况进行评价,记录两组患者 PCIA泵首次触发时间、有效按压次数和芬太尼总量。分别于术前(T0)、术后6 h(T1)、24 h(T2)、48 h(T3)和72 h(T4)采集患者静脉血,采用FACS Calibur流式细胞仪检测T淋巴细胞亚群CD3+、CD4+和CD8+以及N K细胞,计算CD4+/CD8+。结果术后4、8、12、24和48 h ,超前组患者疼痛评分均低于对照组,差异均具有统计学意义(均 P<0.05);超前组患者PCIA首次触发时间晚于对照组,有效按压次数和芬太尼总量均少于对照组(均 P<0.05)。T1、T2和T3时点,超前组CD3+与CD4+细胞比例均高于对照组(均 P<0.05);T1和 T2时点,超前组CD4+/CD8+均高于对照组(均 P<0.05);T2和T3时点,超前组NK细胞比例均高于对照组(均 P<0.05)。结论帕瑞昔布钠超前镇痛应用于子宫肌瘤患者能够减轻患者术后疼痛,减少镇痛药用量,减轻免疫抑制,改善患者术后细胞免疫功能。%Objective To investigate effects of parecoxib sodium preemptive analgesia on postoperative analgesia and cellu‐lar immune function in patients with uterine fibroids.Methods Totally ,116 cases of patients receiving uterine fibroids surgery were selected from March 2011 to April 2014 in our hospital.All cases were randomly divided into advanced group(n=58)and control group(n=58). The cases in the advanced group were intravenously injected with parecoxib sodium(40 mg)30 min before anesthesia ,while

  12. OTO: Ontology Term Organizer.

    Science.gov (United States)

    Huang, Fengqiong; Macklin, James A; Cui, Hong; Cole, Heather A; Endara, Lorena

    2015-02-15

    The need to create controlled vocabularies such as ontologies for knowledge organization and access has been widely recognized in various domains. Despite the indispensable need of thorough domain knowledge in ontology construction, most software tools for ontology construction are designed for knowledge engineers and not for domain experts to use. The differences in the opinions of different domain experts and in the terminology usages in source literature are rarely addressed by existing software. OTO software was developed based on the Agile principles. Through iterations of software release and user feedback, new features are added and existing features modified to make the tool more intuitive and efficient to use for small and large data sets. The software is open source and built in Java. Ontology Term Organizer (OTO; http://biosemantics.arizona.edu/OTO/ ) is a user-friendly, web-based, consensus-promoting, open source application for organizing domain terms by dragging and dropping terms to appropriate locations. The application is designed for users with specific domain knowledge such as biology but not in-depth ontology construction skills. Specifically OTO can be used to establish is_a, part_of, synonym, and order relationships among terms in any domain that reflects the terminology usage in source literature and based on multiple experts' opinions. The organized terms may be fed into formal ontologies to boost their coverage. All datasets organized on OTO are publicly available. OTO has been used to organize the terms extracted from thirty volumes of Flora of North America and Flora of China combined, in addition to some smaller datasets of different taxon groups. User feedback indicates that the tool is efficient and user friendly. Being open source software, the application can be modified to fit varied term organization needs for different domains.

  13. Fixed-Term Homotopy

    Directory of Open Access Journals (Sweden)

    Hector Vazquez-Leal

    2013-01-01

    Full Text Available A new tool for the solution of nonlinear differential equations is presented. The Fixed-Term Homotopy (FTH delivers a high precision representation of the nonlinear differential equation using only a few linear algebraic terms. In addition to this tool, a procedure based on Laplace-Padé to deal with the truncate power series resulting from the FTH method is also proposed. In order to assess the benefits of this proposal, two nonlinear problems are solved and compared against other semianalytic methods. The obtained results show that FTH is a power tool capable of generating highly accurate solutions compared with other methods of literature.

  14. Glossary of Television Terms

    Science.gov (United States)

    1987-11-01

    used for television production equipment designed to be portable and weatherized for outdoor use. The EFP systems are supposed to be of better quality...normal polarity. The result is a picture in which the white and black areas are reversed. NEMO --The term for a remote television program that origi

  15. Meaningless terms in rewriting

    NARCIS (Netherlands)

    Kennaway, R.; Oostrom, V. van; Vries, F.-J. de

    2008-01-01

    We present an axiomatic approach to the concept of meaninglessness in finite and transfinite term rewriting and lambda calculus. We justify our axioms in several ways. They can be intuitively justified from the viewpoint of rewriting as computation. They are shown to imply important properties of me

  16. Long-Term Collections

    CERN Multimedia

    Comité des collectes à long terme

    2011-01-01

    It is the time of the year when our fireman colleagues go around the laboratory for their traditional calendars sale. A part of the money of the sales will be donated in favour of the long-term collections. We hope that you will welcome them warmly.

  17. Half term report

    CERN Multimedia

    2011-01-01

    This week marks the mid-point of my mandate as Director General, so what better time to take stock of the last two and a half years and look forward to the next?    On the surface, the report is good. The LHC is performing well, Council has just approved our medium term plan, and the there seem to be few clouds on CERN’s long-term horizon. It’s precisely at times like this, however, that complacency would be most dangerous. The world is still in the grip of an economic crisis, and recovery in our Member States is slow. CERN is still in debt, as are our social security systems. We are working on this, but these factors need constant and careful attention. While we need to remain vigilant, I’d like to focus on the positives for my mid term message. Let’s start with the LHC. The machine’s performance this year has been fantastic. We achieved our target luminosity for the year in June, which augurs well for the summer conferences. I don&r...

  18. Pediatric polytrauma : Short-term and long-term outcomes

    NARCIS (Netherlands)

    vanderSluis, CK; Kingma, J; Eisma, WH; tenDuis, HJ

    1997-01-01

    Objective: To assess the short-term and long-term outcomes of pediatric polytrauma patients and to analyze the extent to which short-term outcomes can predict long-term outcomes. Materials and Methods: Ail pediatric polytrauma patients (Injury Severity Score of greater than or equal to 16, less than

  19. Long-Term Collections

    CERN Multimedia

    Staff Association

    2016-01-01

    45 years helping in developing countries! CERN personnel have been helping the least fortunate people on the planet since 1971. How? With the Long-Term Collections! Dear Colleagues, The Staff Association’s Long-Term Collections (LTC) Committee is delighted to share this important milestone in the life of our Laboratory with you. Indeed, whilst the name of CERN is known worldwide for scientific discoveries, it also shines in the many humanitarian projects which have been supported by the LTC since 1971. Several schools and clinics, far and wide, carry its logo... Over the past 45 years, 74 projects have been supported (9 of which are still ongoing). This all came from a group of colleagues who wanted to share a little of what life offered them here at CERN, in this haven of mutual understanding, peace and security, with those who were less fortunate elsewhere. Thus, the LTC were born... Since then, we have worked as a team to maintain the dream of these visionaries, with the help of regular donat...

  20. Long-Term Collection

    CERN Document Server

    Staff Association

    2016-01-01

    Dear Colleagues, As previously announced in Echo (No. 254), your delegates took action to draw attention to the projects of the Long-Term Collections (LTC), the humanitarian body of the CERN Staff Association. On Tuesday, 11 October, at noon, small Z-Cards were widely distributed at the entrances of CERN restaurants and we thank you all for your interest. We hope to have achieved an important part of our goal, which was to inform you, convince you and find new supporters among you. We will find out in the next few days! An exhibition of the LTC was also set up in the Main Building for the entire week. The Staff Association wants to celebrate the occasion of the Long-Term Collection’s 45th anniversary at CERN because, ever since 1971, CERN personnel have showed great support in helping the least fortunate people on the planet in a variety of ways according to their needs. On a regular basis, joint fundraising appeals are made with the Directorate to help the victims of natural disasters around th...

  1. Collectes à long terme

    CERN Document Server

    Collectes à long terme

    2014-01-01

    En cette fin d’année 2014 qui approche à grands pas, le Comité des Collectes à Long Terme remercie chaleureusement ses fidèles donatrices et donateurs réguliers pour leurs contributions à nos actions en faveur des plus démunis de notre planète. C’est très important, pour notre Comité, de pouvoir compter sur l’appui assidu que vous nous apportez. Depuis plus de 40 ans maintenant, le modèle des CLT est basé principalement sur des actions à long terme (soit une aide pendant 4-5 ans par projet, mais plus parfois selon les circonstances), et sa planification demande une grande régularité de ses soutiens financiers. Grand MERCI à vous ! D’autres dons nous parviennent au cours de l’année, et ils sont aussi les bienvenus. En particulier, nous tenons à remercier...

  2. MR-guided Focused Ultrasound for Uterine Fibroids

    Science.gov (United States)

    ... uterus and prevents a woman from ever getting pregnant. MRgFUS helps preserve the uterus (and thus a woman’s ability to potentially become pregnant) and is performed on an outpatient basis. top ...

  3. MR-guided Focused Ultrasound for Uterine Fibroids

    Science.gov (United States)

    ... being imaged, send and receive radio waves, producing signals that are detected by the coils. The electric current does not come in contact with the patient. A computer then processes the signals and generates a series of images, each of ...

  4. Research on genesis of adipocytic metaplasia in uterine fibroids.

    Science.gov (United States)

    Sośnik, Henryk; Jeleń, Michał; Kosiński, Mariusz; Sośnik, Katarzyna

    2015-12-01

    The genesis of lipoleiomyoma has not been explained yet. Immunohistochemical examinations were performed on 17 lipoleiomyomas in women aged 43-82 (mean age: 51 ±9 years). Four types of myomas were distinguished: 1) pure leiomyoma, 2) fibroleiomyoma, 3) hyalinizing leiomyoma, 4) strongly hyalinized myoma, along with three degrees of progression of adipocytic metaplasia: 1) up to 25% of lipocytes, 2) up to 50% of lipocytes, and 3) over 50% of lipocytes in the analyzed sample, along with three degrees of progression of adipocytic metaplasia: 1) up to 25% of lipocytes, 2) up to 50% of lipocytes, and 3) over 50% of lipocytes in the analyzed sample. A positive correlation was found between the age of women and rate of development of metaplasia (r = 0.51, p = 0.035) as well as with activity of the estrogen receptor in the primary tumor (r = 0.53, p = 0.03). New mucous perivascular tissue was reported among 11.8% of patients and on this basis lipocytes were formed. The appearance of subendothelial granular cells of large blood vessels with a positive reaction for smooth muscle actin (SMA) and CD68 was reported in 17.7%. Results of immunohistochemical research seem to confirm that lipocytes de novo come from the primal pluripotent cells of the tumor stroma and not from the fatty degeneration of myocytes.

  5. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

    DEFF Research Database (Denmark)

    Vanharanta, S; Pollard, PJ; Lehtonen, HJ

    2006-01-01

    Defects in mitochondrial enzymes predispose to severe developmental defects as well as tumorigenesis. Heterozygous germline mutations in the nuclear gene encoding fumarate hydratase (FH), an enzyme catalyzing the hydration of fumarate in the Krebs tricarboxylic acid cycle, cause hereditary...

  6. Diversification: Far term (2000 - )

    Science.gov (United States)

    1975-01-01

    Diversification, intended to underly the far term of the energy conservation program, was defined to imply conservation through substitution for scarce energy resources by maximizing the total number of viable energy system types in every sector. The following requirements or aspects of diversification that must be studied were given: fuel mix and end use patterns for various alternative diversification plans, current status of diversification, advantages and disadvantages of diversification, constraints and criteria, diversification actions and their controls, and means for implementing the chosen diversification strategy. The following advantages resulting from diversification were described: competition, crisis-related situations, local energy production, decentralized plant locations, long range energy policy, and environmental overloads. The major criteria by which a diversification program should be judged, the major constraints affecting the approaches, and the road to diversification, were elaborated.

  7. Diversification: Far term (2000 - )

    Science.gov (United States)

    1975-01-01

    Diversification, intended to underly the far term of the energy conservation program, was defined to imply conservation through substitution for scarce energy resources by maximizing the total number of viable energy system types in every sector. The following requirements or aspects of diversification that must be studied were given: fuel mix and end use patterns for various alternative diversification plans, current status of diversification, advantages and disadvantages of diversification, constraints and criteria, diversification actions and their controls, and means for implementing the chosen diversification strategy. The following advantages resulting from diversification were described: competition, crisis-related situations, local energy production, decentralized plant locations, long range energy policy, and environmental overloads. The major criteria by which a diversification program should be judged, the major constraints affecting the approaches, and the road to diversification, were elaborated.

  8. Handbook of mechanical engineering terms

    CERN Document Server

    Ramalingam, KK

    2009-01-01

    About the Book: The Handbook of Mechanical Engineering terms contains short, precise definitions of about four thousand terms. These terms have been collected from different sources, edited and grouped under twenty six parts and given alphabetically under each part for easy reference. The book will be a source of guidance and help to the students, staff and practising engineers in understanding and updating the subject matter. Contents: The Handbook of Mechanical Engineering terms contains short, precise definitions of about four thousand terms. These terms have been collected from differ

  9. Glossary of television terms

    Science.gov (United States)

    1982-09-01

    This glossary was compiled by the members and associate members of the Range Commanders Council (RCC) Optical Systems Group (OSG). The OSG recognizes that the utilization of television for data gathering purposes has increased drastically in the last decade. Because many of the personnel involved in range operations and maintenance have a limited background in television, the OSG membership felt that a glossary containing selected television terminology would contribute to understanding the theoretical, engineering, operational, and maintenance applications of television. Since the term 'television' covers a broad spectrum, many of the words and phrases that apply solely to broadcast and Community Antenna Television (CATV) have not been included here. Also it has been assumed that the user of this publication will not be applying any television technology aside from periodic video tape editing. Furthermore, it is assumed that most of the video tape editing which takes place will be confined to tape-to-tape editing utilizing the built-in features characteristic of video recorders currently available.

  10. A profession termed Journalism

    Directory of Open Access Journals (Sweden)

    Manuel Fernández Areal, Ph. D.

    2010-01-01

    Full Text Available New technologies can foster the impression that journalism, as a profession will become extinct probably in a short term. Anybody can have access to any information sources as well as to transmit – through Internet- all sorts of messages at an unusual speed, and this fact seems to support the idea that no technical training will be needed in the future not even an specific cultural background will be required, much less an university degree or qualification that ensures a responsible and appropriate practice of the modern social communication. The Federation of Journalists Associations in Spain (FAPE in its Draft of the Professional Statute is in favor of a graduated or qualified profession at an university level, and its Commission for Complaints has been developing a successful work regarding the professional self-regulation and self-control for the benefit of society. Therefore, there are good reasons for being optimist. Journalism, as a profession, is not going to disappear, and maybe it is time to consider it, really, as an academic qualified profession.

  11. LONG TERM COLLECTIONS

    CERN Multimedia

    STAFF ASSOCIATION

    2010-01-01

    ACKNOWLEDGMENTS The Long-Term Collections (CLT) committee would like to warmly thank its faithful donors who, year after year, support our actions all over the world. Without you, all this would not be possible. We would like to thank, in particular, the CERN Firemen’s Association who donated 5000 CHF in the spring thanks to the sale of their traditional calendar, and the generosity of the CERN community. A huge thank you to the firemen for their devotion to our cause. And thank you to all those who have opened their door, their heart, and their purses! Similarly, we warmly thank the CERN Yoga Club once again for its wonderful donation of 2000 CHF we recently received. We would also like to tell you that all our projects are running well. Just to remind you, we are currently supporting the activities of the «Réflexe-Partage» Association in Mali; the training centre of «Education et Développement» in Abomey, Benin; and the orphanage and ...

  12. Complex Landscape Terms in Seri

    Science.gov (United States)

    O'Meara, Carolyn; Bohnemeyer, Jurgen

    2008-01-01

    The nominal lexicon of Seri is characterized by a prevalence of analytical descriptive terms. We explore the consequences of this typological trait in the landscape domain. The complex landscape terms of Seri classify geographic entities in terms of their material make-up and spatial properties such as shape, orientation, and merological…

  13. 46 CFR Sec. 2 - Terms.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Terms. Sec. 2 Section 2 Shipping MARITIME ADMINISTRATION... PREPARATION OF INVOICES AND PAYMENT OF COMPENSATION PURSUANT TO PROVISIONS OF NSA ORDER NO. 47 Sec. 2 Terms. The terms employed in this order shall have the same meaning as those contained in NSA Order No. 47....

  14. Medium and long term load forecasting considering data uncertainty%考虑数据不确定性的中长期电力负荷预测

    Institute of Scientific and Technical Information of China (English)

    郑志杰; 李磊; 赵兰明

    2011-01-01

    中长期负荷预测时间跨度较长,其基础数据受诸多因素影响,具有不确定性和不可控性.引入蒙特卡罗算法和区间算法处理中长期负荷预测中的数据不确定性问题.根据历史年度实际情况,假定基础数据在某一范围内存在不确定性,采用蒙特卡罗算法构建了计算流程,可以得到界于某一区间的负荷预测值;采用区间算法描述基础数据的不确定性,针对区间算法固有的过估计问题,通过推导适合的公式,可以避免产生过度保守的结果,只需一次计算,就可以严格分析数据不确定性对预测结果的影响,具有节省计算时间的优点.在考虑基础数据存在不确定性情况下,通过某省电网负荷预测实例计算并与传统预测方法相比较,验证了两种负荷预测方法可以评估数据不确定性对负荷结果的影响,避免得到过度保守的负荷预测值.%Mid-long term load forecasting goes through a long time and the base data are influenced by a number of factors, most of which are beyond the control and with uncertainty. In order to deal with the data uncertainty problem in mid-long term load forecasting, Monte Carlo method and interval arithmetic are introduced. According to actual situation in history, it is assumed that the base data have uncertainty in a certain range. Using Monte Carlo method to construct the calculation process can obtain the load prediction result in a certain interval. Using interval algorithm to describe the uncertainty of base data, and for reducing overestimation of interval arithmetic, suitable formula is deduced to avoid the conservative results, with the advantages of saving computing time because only once computation can seriously analyze the effect of data uncertainty on prediction results. The proposed two methods have been tested on the load forecasting of one province. In consideration of the base data with uncertainty,by comparing with conventional load forecasting

  15. Rewriting and suppressing UMLS terms for improved biomedical term identification

    Directory of Open Access Journals (Sweden)

    Hettne Kristina M

    2010-03-01

    Full Text Available Abstract Background Identification of terms is essential for biomedical text mining.. We concentrate here on the use of vocabularies for term identification, specifically the Unified Medical Language System (UMLS. To make the UMLS more suitable for biomedical text mining we implemented and evaluated nine term rewrite and eight term suppression rules. The rules rely on UMLS properties that have been identified in previous work by others, together with an additional set of new properties discovered by our group during our work with the UMLS. Our work complements the earlier work in that we measure the impact on the number of terms identified by the different rules on a MEDLINE corpus. The number of uniquely identified terms and their frequency in MEDLINE were computed before and after applying the rules. The 50 most frequently found terms together with a sample of 100 randomly selected terms were evaluated for every rule. Results Five of the nine rewrite rules were found to generate additional synonyms and spelling variants that correctly corresponded to the meaning of the original terms and seven out of the eight suppression rules were found to suppress only undesired terms. Using the five rewrite rules that passed our evaluation, we were able to identify 1,117,772 new occurrences of 14,784 rewritten terms in MEDLINE. Without the rewriting, we recognized 651,268 terms belonging to 397,414 concepts; with rewriting, we recognized 666,053 terms belonging to 410,823 concepts, which is an increase of 2.8% in the number of terms and an increase of 3.4% in the number of concepts recognized. Using the seven suppression rules, a total of 257,118 undesired terms were suppressed in the UMLS, notably decreasing its size. 7,397 terms were suppressed in the corpus. Conclusions We recommend applying the five rewrite rules and seven suppression rules that passed our evaluation when the UMLS is to be used for biomedical term identification in MEDLINE. A software

  16. Cranial sonography in term and near-term infants

    Energy Technology Data Exchange (ETDEWEB)

    Yikilmaz, Ali [Gevher Nesibe Hospital and Erciyes Medical School, Department of Radiology, Talas, Kayseri (Turkey); Taylor, George A. [Children' s Hospital Boston and Harvard Medical School, Department of Radiology, Boston, MA (United States)

    2008-06-15

    Sonographic patterns of brain injury in the term and near-term infant are quite different from those in the premature infant. Although periventricular leukomalacia and germinal matrix hemorrhage are rarely seen in term infants, selective neuronal injury, parasagittal infarction, focal stroke, diffuse hypoxic-ischemic injury, and deep parenchymal hemorrhages are more common lesions. In addition, congenital brain tumors, hamartomatous lesions, such as hemimegalencephaly, and tuberous sclerosis can mimic ischemic and hemorrhagic injury. Sonography remains an important tool in the initial evaluation of intracranial abnormalities in critically ill term and near-term infants. An understanding of the differences in etiology, sonographic patterns, and limitations of sonography in the term infant is essential for accurate and effective diagnoses in this age group. (orig.)

  17. Gogny interactions with tensor terms

    Energy Technology Data Exchange (ETDEWEB)

    Anguiano, M.; Lallena, A.M.; Bernard, R.N. [Universidad de Granada, Departamento de Fisica Atomica, Molecular y Nuclear, Granada (Spain); Co' , G. [INFN, Lecce (Italy); De Donno, V. [Universita del Salento, Dipartimento di Matematica e Fisica ' ' E. De Giorgi' ' , Lecce (Italy); Grasso, M. [Universite Paris-Sud, Institut de Physique Nucleaire, IN2P3-CNRS, Orsay (France)

    2016-07-15

    We present a perturbative approach to include tensor terms in the Gogny interaction. We do not change the values of the usual parameterisations, with the only exception of the spin-orbit term, and we add tensor terms whose only free parameters are the strengths of the interactions. We identify observables sensitive to the presence of the tensor force in Hartree-Fock, Hartree-Fock-Bogoliubov and random phase approximation calculations. We show the need of including two tensor contributions, at least: a pure tensor term and a tensor-isospin term. We show results relevant for the inclusion of the tensor term for single-particle energies, charge-conserving magnetic excitations and Gamow-Teller excitations. (orig.)

  18. Rewriting and suppressing UMLS terms for improved biomedical term identification

    NARCIS (Netherlands)

    K.M. Hettne (Kristina); E.M. van Mulligen (Erik); M.J. Schuemie (Martijn); R.J.A. Schijvenaars (Bob); J.A. Kors (Jan)

    2010-01-01

    textabstractBackground: Identification of terms is essential for biomedical text mining. We concentrate here on the use of vocabularies for term identification, specifically the Unified Medical Language System (UMLS). To make the UMLS more suitable for biomedical text mining we implemented and evalu

  19. Long-term urethral catheterisation.

    Science.gov (United States)

    Turner, Bruce; Dickens, Nicola

    This article discusses long-term urethral catheterisation, focusing on the relevant anatomy and physiology, indications for the procedure, catheter selection and catheter care. It is important that nurses have a good working knowledge of long-term catheterisation as the need for this intervention will increase with the rise in chronic health conditions and the ageing population.

  20. Telecommunications glossary of telecommunications terms

    CERN Document Server

    1997-01-01

    This glossary contains more than 5,000 technical terms and definitions that were standardized by the federal government for use by international and U.S. government telecommunications specialists. It includes international and national terms drawn from the International Telecommunication Union, the International Organization for Standardization, the TIA, ANSI, and others.

  1. What Do Mental Terms Mean?

    Science.gov (United States)

    Moore, Jay

    2010-01-01

    Psychologists and philosophers have long been interested in two questions: (a) What do mental terms mean? and (b) what role do mental terms play in explanations of behavior? In the current sketch I review how mediational neobehaviorism, cognitive psychology, and the radical behaviorism of B. F. Skinner address these questions. In so doing, I seek…

  2. What Do Mental Terms Mean?

    Science.gov (United States)

    Moore, Jay

    2010-01-01

    Psychologists and philosophers have long been interested in two questions: (a) What do mental terms mean? and (b) what role do mental terms play in explanations of behavior? In the current sketch I review how mediational neobehaviorism, cognitive psychology, and the radical behaviorism of B. F. Skinner address these questions. In so doing, I seek…

  3. Boundary terms of conformal anomaly

    Directory of Open Access Journals (Sweden)

    Sergey N. Solodukhin

    2016-01-01

    Full Text Available We analyze the structure of the boundary terms in the conformal anomaly integrated over a manifold with boundaries. We suggest that the anomalies of type B, polynomial in the Weyl tensor, are accompanied with the respective boundary terms of the Gibbons–Hawking type. Their form is dictated by the requirement that they produce a variation which compensates the normal derivatives of the metric variation on the boundary in order to have a well-defined variational procedure. This suggestion agrees with recent findings in four dimensions for free fields of various spins. We generalize this consideration to six dimensions and derive explicitly the respective boundary terms. We point out that the integrated conformal anomaly in odd dimensions is non-vanishing due to the boundary terms. These terms are specified in three and five dimensions.

  4. Boundary terms of conformal anomaly

    Energy Technology Data Exchange (ETDEWEB)

    Solodukhin, Sergey N., E-mail: Sergey.Solodukhin@lmpt.univ-tours.fr

    2016-01-10

    We analyze the structure of the boundary terms in the conformal anomaly integrated over a manifold with boundaries. We suggest that the anomalies of type B, polynomial in the Weyl tensor, are accompanied with the respective boundary terms of the Gibbons–Hawking type. Their form is dictated by the requirement that they produce a variation which compensates the normal derivatives of the metric variation on the boundary in order to have a well-defined variational procedure. This suggestion agrees with recent findings in four dimensions for free fields of various spins. We generalize this consideration to six dimensions and derive explicitly the respective boundary terms. We point out that the integrated conformal anomaly in odd dimensions is non-vanishing due to the boundary terms. These terms are specified in three and five dimensions.

  5. Area terms in entanglement entropy

    CERN Document Server

    Casini, Horacio; Lino, Eduardo Testé

    2014-01-01

    We discuss area terms in entanglement entropy and show that a recent formula by Rosenhaus and Smolkin is equivalent to the term involving a correlator of traces of the stress tensor in Adler-Zee formula for the renormalization of the Newton constant. We elaborate on how to fix the ambiguities in these formulas: Improving terms for the stress tensor of free fields, boundary terms in the modular Hamiltonian, and contact terms in the Euclidean correlation functions. We make computations for free fields and show how to apply these calculations to understand some results for interacting theories which have been studied in the literature. We also discuss an application to the F-theorem.

  6. Meat and Poultry Labeling Terms

    Science.gov (United States)

    ... regulations enacted in 2004 to protect consumers against Bovine Spongiform Encephalopathy, mechanically separated beef is considered inedible ... in raising the animals. [ Top of Page ] NO ANTIBIOTICS (red meat and poultry): The terms "no antibiotics ...

  7. Supernatural A-Term Inflation

    Science.gov (United States)

    Lin, Chia-Min; Cheung, Kingman

    Following Ref. 10, we explore the parameter space of the case when the supersymmetry (SUSY) breaking scale is lower, for example, in gauge mediated SUSY breaking model. During inflation, the form of the potential is V0 plus MSSM (or A-term) inflation. We show that the model works for a wide range of the potential V0 with the soft SUSY breaking mass m O(1) TeV. The implication to MSSM (or A-term) inflation is that the flat directions which is lifted by the non-renormalizable terms described by the superpotential W=λ p φ p-1/Mp-3 P with p = 4 and p = 5 are also suitable to be an inflaton field for λp = O(1) provided there is an additional false vacuum term V0 with appropriate magnitude. The flat directions correspond to p = 6 also works for 0 < ˜ V0/M_ P4 < ˜ 10-40.

  8. Definitions of Health Terms: Nutrition

    Science.gov (United States)

    ... gov/definitions/nutritiondefinitions.html Definitions of Health Terms: Nutrition To use the sharing features on this page, ... National Institutes of Health, Office of Dietary Supplements Nutrition This field of study focuses on foods and ...

  9. NCI Dictionary of Genetics Terms

    Science.gov (United States)

    A dictionary of more than 150 genetics-related terms written for healthcare professionals, developed to support the comprehensive, evidence-based, peer-reviewed PDQ cancer genetics information summaries.

  10. Boundary Terms for Causal Sets

    CERN Document Server

    Buck, Michel; Jubb, Ian; Surya, Sumati

    2015-01-01

    We propose a family of boundary terms for the action of a causal set with a spacelike boundary. We show that in the continuum limit one recovers the Gibbons-Hawking-York boundary term in the mean. We also calculate the continuum limit of the mean causal set action for an Alexandrov interval in flat spacetime. We find that it is equal to the volume of the codimension-2 intersection of the two light-cone boundaries of the interval.

  11. FlexiTerm: a flexible term recognition method

    NARCIS (Netherlands)

    Spasic, I.; Greenwood, M.; Preece, A.; Francis, N.; Elwyn, G.

    2013-01-01

    BACKGROUND: The increasing amount of textual information in biomedicine requires effective term recognition methods to identify textual representations of domain-specific concepts as the first step toward automating its semantic interpretation. The dictionary look-up approaches may not always be sui

  12. Analysing long term discursive processes

    DEFF Research Database (Denmark)

    Horsbøl, Anders

    What do timescales - the notion that processes take place or can be viewed within a shorter or longer temporal range (Lemke 2005) - mean for the analysis of discourse? What are the methodological consequences of analyzing discourse at different timescales? It may be argued that discourse analysis...... in general has favored either the analysis of short term processes such as interviews, discussions, and lessons, or the analysis of non-processual entities such as (multimodal) texts, arguments, discursive repertoires, and discourses (in a Foucaultian sense). In contrast, analysis of long term processes...... which extend beyond the single interaction, for instance negotiations or planning processes, seems to have played a less important role, with studies such as Iedema 2001 and Wodak 2000 as exceptions. These long term processes, however, are central to the constitution and workings of organizations...

  13. Confining Strings with Topological Term

    CERN Document Server

    Diamantini, M Cristina; Trugenberger, Carlo Andrea

    1997-01-01

    We consider several aspects of `confining strings', recently proposed to describe the confining phase of gauge field theories. We perform the exact duality transformation that leads to the confining string action and show that it reduces to the Polyakov action in the semiclassical approximation. In 4D we introduce a `$\\theta$-term' and compute the low-energy effective action for the confining string in a derivative expansion. We find that the coefficient of the extrinsic curvature (stiffness) is negative, confirming previous proposals. In the absence of a $\\theta$-term, the effective string action is only a cut-off theory for finite values of the coupling e, whereas for generic values of $\\theta$, the action can be renormalized and to leading order we obtain the Nambu-Goto action plus a topological `spin' term that could stabilize the system.

  14. Necrotizing enterocolitis in term infants.

    Science.gov (United States)

    Christensen, Robert D; Lambert, Diane K; Baer, Vickie L; Gordon, Phillip V

    2013-03-01

    This article is an overview of NEC in term neonates and also summarizes data from 52 cases within Intermountain Healthcare during the last 11 years. In all 52, NEC occurred among neonates already admitted to a neonatal intensive care unit for some other reason; thus, NEC invariably developed as a complication of treatment, not as a primary diagnosis. The authors speculate that the incidence of term NEC can be reduced by identifying neonatal intensive care unit patients at risk for NEC and applying appropriate-volume human milk feeding programs for these patients.

  15. Time-varying cosmological term

    Science.gov (United States)

    Socorro, J.; D'oleire, M.; Pimentel, Luis O.

    2015-11-01

    We present the case of time-varying cosmological term using the Lagrangian formalism characterized by a scalar field ϕ with standard kinetic energy and arbitrary potential V(ϕ). This model is applied to Friedmann-Robertson-Walker (FRW)cosmology. Exact solutions of the field equations are obtained by a special ansats to solve the Einstein-Klein-Gordon equation and a particular potential for the scalar field and barotropic perfect fluid. We present the evolution on this cosmological term with different scenarios.

  16. Superconformal D-term inflation

    Energy Technology Data Exchange (ETDEWEB)

    Buchmüller, W.; Domcke, V.; Schmitz, K., E-mail: wilfried.buchmueller@desy.de, E-mail: valerie.domcke@desy.de, E-mail: kai.schmitz@ipmu.jp [Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg (Germany)

    2013-04-01

    We study models of hybrid inflation in the framework of supergravity with superconformal matter. F-term hybrid inflation is not viable since the inflaton acquires a large tachyonic mass. On the contrary, D-term hybrid inflation can successfully account for the amplitude of the primordial power spectrum. It is a two-field inflation model which, depending on parameters, yields values of the scalar spectral index down to n{sub s} ≅ 0.96. Generically, there is a tension between a small spectral index and the cosmic string bound albeit, within 2σ uncertainty, the current observational bounds can be simultaneously fulfilled.

  17. CRED Acoustic Doppler Profiler (ADP); NWHI, MID; Long: -177.42181, Lat: 28.21826 (WGS84); Sensor Depth: 1.83m; Data Range: 20080926-20090321.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data from Coral Reef Ecosystem Division (CRED), NOAA Pacific Island Fisheries Science Center Acoustic Doppler Profilers (ADP) provide a time series of water current...

  18. CRED Subsurface Temperature Recorder (STR); NWHI, MID; Long: -177.38602, Lat: 28.27105 (WGS84); Sensor Depth: 1.52m; Data Range: 20041010-20060915.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data from Coral Reef Ecosystem Division (CRED), NOAA Pacific Islands Fisheries Science Center (PIFSC) Subsurface Temperature Recorders (STR) provide a time series of...

  19. CRED Subsurface Temperature Recorder (STR); NWHI, MID; Long: -177.32340, Lat: 28.24453 (WGS84); Sensor Depth: 0.91m; Data Range: 20041003-20060915.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data from Coral Reef Ecosystem Division (CRED), NOAA Pacific Islands Fisheries Science Center (PIFSC) Subsurface Temperature Recorders (STR) provide a time series of...

  20. CRED Subsurface Temperature Recorder (STR); NWHI, MID; Long: -177.40181, Lat: 28.19361 (WGS84); Sensor Depth: 1.00m; Data Range: 20030729-20041001.

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Data from Coral Reef Ecosystem Division (CRED), NOAA Pacific Islands Fisheries Science Center (PIFSC) Subsurface Temperature Recorders (STR) provide a time series of...

  1. Redefining The Term of Dukun

    Directory of Open Access Journals (Sweden)

    Sartini

    2017-02-01

    Full Text Available Dukun, wong pinter, and other terms, commonly constitutes to the term of shamanism, are often interpreted in the same way. In particular, the dukun and wong pinter are generally understood as persons who have extraordinary or even supernatural powers, are capable of communicating with spirits and understanding the unseen, can generally help resolve issues faced by members of their communities, including illnesses, spiritual disturbances, lost items, unfortunate fates, etc. They are also predicated to charge to the patient and even willing to help witchcraft to harm other people. In fact, not all shamans have negative behaviors. In Temanggung, Central Java, though this general understanding is still common, there is distinction in the specific details and characteristics of the dukun and wong pinter. Dukun are often understood negatively, meanwhile the wong pinter has more positive connotations. Because of the different principle meaning the both terms should not be generalized and used appropriately and wisely. Improper use can cause discomfort in the community, and academically the both term actually refers to a completely different subject characteristics.

  2. History of Physical Terms: "Pressure"

    Science.gov (United States)

    Frontali, Clara

    2013-01-01

    Scientific terms drawn from common language are often charged with suggestions that may even be inconsistent with their restricted scientific meaning, thus posing didactic problems. The (non-linear) historical journey of the word "pressure" is illustrated here through original quotations from Stevinus, Torricelli, Pascal, Boyle,…

  3. Locative Terms and Warlpiri Acquisition.

    Science.gov (United States)

    Bavin, Edith L.

    1990-01-01

    Focuses on the influence of language specific properties in the acquisition of locative expressions. Some of the claims from literature on the acquisition of locative expressions are discussed and data from the acquisition of Warlpiri are presented and discussed in terms of these claims. (Author/CB)

  4. History of Physical Terms: "Pressure"

    Science.gov (United States)

    Frontali, Clara

    2013-01-01

    Scientific terms drawn from common language are often charged with suggestions that may even be inconsistent with their restricted scientific meaning, thus posing didactic problems. The (non-linear) historical journey of the word "pressure" is illustrated here through original quotations from Stevinus, Torricelli, Pascal, Boyle,…

  5. Definitions of Health Terms: Fitness

    Science.gov (United States)

    ... this page: https://medlineplus.gov/definitions/fitnessdefinitions.html Definitions of Health Terms: Fitness To use the sharing features on ... the most of your exercise routine. Find more definitions on Fitness | General Health | Minerals | Nutrition | Vitamins Activity Count Physical activity is ...

  6. Definitions of Health Terms: Minerals

    Science.gov (United States)

    ... this page: https://medlineplus.gov/definitions/mineralsdefinitions.html Definitions of Health Terms : Minerals To use the sharing features on ... of the minerals that you need. Find more definitions on Fitness | General Health | Minerals | Nutrition | Vitamins Antioxidants Antioxidants are substances that ...

  7. Islam: Basic Terms and Concepts.

    Science.gov (United States)

    Wires, Richard

    1983-01-01

    The news media constantly uses words and references that require specific knowledge and understanding if the public is to grasp the substance and implications of events and developments concerning the Islamic religion. Most frequently encountered Islamic terms and ideas are explained. (RM)

  8. Pattern Based Term Extraction Using ACABIT System

    CERN Document Server

    Takeuchi, Koichi; Koyama, Teruo; Daille, Béatrice; Romary, Laurent

    2009-01-01

    In this paper, we propose a pattern-based term extraction approach for Japanese, applying ACABIT system originally developed for French. The proposed approach evaluates termhood using morphological patterns of basic terms and term variants. After extracting term candidates, ACABIT system filters out non-terms from the candidates based on log-likelihood. This approach is suitable for Japanese term extraction because most of Japanese terms are compound nouns or simple phrasal patterns.

  9. Groupoids with Only Linear Term Functions

    Institute of Scientific and Technical Information of China (English)

    Jung R. Cho; Józef Dudek

    2001-01-01

    When one deals with terms over algebras, it is quite natural to look for the simplest terms which represent all the terms, and it will be very convenient for many reasons if every term can be represented by a linear term, as in the cases of modules, semilattices, Boolean groups, affine spaces, and so on. On the other hand, the linearity of terms imposes much restraint on the structure and properties of the algebra. We call an algebra term-linear if every term is equal to some linear term or constant function and every linear term is essential in the sense that it depends on each variable it involves. In this paper, we study some properties and identities of term-linear groupoids, and characterize term-linear semigroups and term-linear commutative idempotent groupoids.

  10. Random walk term weighting for information retrieval

    DEFF Research Database (Denmark)

    Blanco, R.; Lioma, Christina

    2007-01-01

    We present a way of estimating term weights for Information Retrieval (IR), using term co-occurrence as a measure of dependency between terms.We use the random walk graph-based ranking algorithm on a graph that encodes terms and co-occurrence dependencies in text, from which we derive term weights...... that represent a quantification of how a term contributes to its context. Evaluation on two TREC collections and 350 topics shows that the random walk-based term weights perform at least comparably to the traditional tf-idf term weighting, while they outperform it when the distance between co-occurring terms...

  11. Automatic term identification for bibliometric mapping

    NARCIS (Netherlands)

    N.J.P. van Eck (Nees Jan); L. Waltman (Ludo); E.C.M. Noyons (Ed); R.K. Buter (Reindert)

    2010-01-01

    textabstractA term map is a map that visualizes the structure of a scientific field by showing the relations between important terms in the field. The terms shown in a term map are usually selected manually with the help of domain experts. Manual term selection has the disadvantages of being subject

  12. Automatic Term Identification for Bibliometric Mapping

    NARCIS (Netherlands)

    N.J.P. van Eck (Nees Jan); L. Waltman (Ludo); E.C.M. Noyons (Ed); R.K. Buter (Reindert)

    2008-01-01

    textabstractA term map is a map that visualizes the structure of a scientific field by showing the relations between important terms in the field. The terms shown in a term map are usually selected manually with the help of domain experts. Manual term selection has the disadvantages of being subject

  13. Mercy as a Theological Term

    Directory of Open Access Journals (Sweden)

    Wojciech Zyzak

    2015-04-01

    Full Text Available The author of the article analyses different meanings of the term ‘mercy’. He begins with the ancient use of the word by pagan philosophers. This is the background for the analysis of the term ‘mercy’ in the Old and New Testament. The biblical sources lead to the definition of dogmatic foundations of God’s Mercy and allow the ethical and moral aspects of the human mercy to be shown. Closely connected with the last is the social dimension of the mercy. The author also deals with other dimensions of the mercy, such as: pastoral, liturgical, psychological and juridical. He also discusses the meaning of the mercy in the spirituality and Christian art.

  14. Path indexing for term retrieval

    OpenAIRE

    1992-01-01

    Different methods for term retrieval in deduction systems have been introduced in literature. This report eviews the three indexing techniques discrimination indexing, path indexing, and abstraction tree indexing. A formal approach to path indexing is presented and algorithms as well as data structures of an existing implementation are discussed. Eventually, experiments will show that our implementation outperforms the implementation of path indexing in the OTTER theorem prover.

  15. Some terms from Greek mythology

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>1.Narcissus—纳西索斯,水仙花,自恋This term comes from a beautiful Greek myth.Narcissus(纳西索斯)is the son of the river god Cephissus and the nymph(宙斯)Leiriope.He was counted among the most handsome Of young men.His mother was told that he would have a long life,proyided he never looked upon his

  16. SOME RANGE MANAGEMENT TERMS AND DEFINITIONS

    Directory of Open Access Journals (Sweden)

    Turan Yüksek

    2003-04-01

    Full Text Available In this study, 79 important rangeland terms have been defined according to current literature. The terms have been defined Turkish alphabetical order and the english meaning of the terms have been given in paranthesis.

  17. Preeclampsia: Short-term and Long-term Implications.

    Science.gov (United States)

    Pauli, Jaimey M; Repke, John T

    2015-06-01

    Preeclampsia is a hypertensive disorder that affects 4% of pregnancies and has a high risk of maternal, fetal, and neonatal morbidity and mortality, as well as long-term cardiovascular risk. Recent updates in the definition, diagnosis, and management guidelines for preeclampsia warrant review by general obstetrician-gynecologists. Screening and prevention algorithms for preeclampsia are available, but ultimately the cure remains delivery of the fetus and placenta. Close monitoring for the development and worsening of preeclampsia during pregnancy is essential to optimize both maternal and fetal/neonatal outcomes.

  18. Do perfume additives termed human pheromones warrant being termed pheromones?

    Science.gov (United States)

    Winman, Anders

    2004-09-30

    Two studies of the effects of perfume additives, termed human pheromones by the authors, have conveyed the message that these substances can promote an increase in human sociosexual behaviour [Physiol. Behav. 75 (2003) R1; Arch. Sex. Behav. 27 (1998) R2]. The present paper presents an extended analysis of this data. It is shown that in neither study is there a statistically significant increase in any of the sociosexual behaviours for the experimental groups. In the control groups of both studies, there are, however, moderate but statistically significant decreases in the corresponding behaviour. Most notably, there is no support in data for the claim that the substances increase the attractiveness of the wearers of the substances to the other sex. It is concluded that more research using matched homogenous groups of participants is needed.

  19. LAPAROSCOPIC MYOMECTOMY

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective. To investigate the indications, surgical techniques and complications of laparoscopic myomectomy. Materials and methods. A retrospective study was carried out in 74 patients with fibroids >3cm from March, 1995 until May,2000 at PUMC Hospital. Indications for surgery were symptomatic fibroids( 20 cases) , mainly pain or urine frequency ; progressively increasing fibroid size (7 cases); coexistent adnexal pathology( 26 cases) and infertility( 21 cases) . Results. The number of fibroids of each patient varied from 1 to 4 with single fibroid of 62 cases (83.7% ).The fibroids were located in anterior wall (30 cases), posterior wall (23 cases) and fundus (21 cases). A total of 93 fibroids were removed from these patients including 16 intramural fibroids and 77 subserous fibroids. The size of dominant fibroids ranged from 3~ 8 cm (mean 4.8 cm). In 19 cases (25.6% ),the uterine wall was sutured in one layer. Mean duration of operation was 73 minutes and mean blood loss was 82 ml. Longer operating time and more blood loss were observed in patients with fibroids≥ 4cm than those with fibroids <4cm. The difference was statistically significant (P< 0.05). Mean postoperative hospital stay was 3.2 days and overall complication rate was 1.4% . The average postoperative follow-up period was 22 months (1~ 62 months). All the patients with symptoms showed remission of their complaints at 2-month follow-up. Recurrence of fibroid occurred in 1 case 1 year after initial operation and second laparoscopic myomectomy was given to her successfully. Five patients became pregnant. The pregnancy was uneventful and proceeded to selective caesarean section at term pregnancy in 4 cases. One miscarriage occured at 8 weeks in the 5th case. No adhesions at myomectomy site were found in these 5 patients. Conclusions. Our study suggests the feasibility of laparoscopic myomectomy in selected patients, which leads to effectiveness, low complication rate and

  20. TRANSITION IN TERMS OF GLOBALISATION

    Directory of Open Access Journals (Sweden)

    Miroslav Milutinović

    2014-10-01

    Full Text Available One of the essential constituents of the term transition, in Serbia as well as in other postsocialistic countries, refers to the transition from one development concept onto another one (extensive and mobilising, which is completely different (market-based and innovation-oriented. Market behaviour rules have changed to a great extent, as well as the increasingly present innovations in the field of technology, and introduced certain innovations in business orientation of companies. The struggle for market share is becoming more aggressive and dynamic enabling the survival of exclusively those companies which have implanted high flexibility and innovation levels into their business ambience. Globalisation is inherent in capitalism, it is its constituent logic. In future, new rules will have to be brought which would allow of the managment function to be performed within the complete business policy mutually agreed upon betwen the representatives of the capital owner and those of the personell. These regulations are necessary for long-term efficiency and profitability of private sector, as well as for the final success of economy.

  1. Modes of Convergence for Term Graph Rewriting

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2011-01-01

    Term graph rewriting provides a simple mechanism to finitely represent restricted forms of infinitary term rewriting. The correspondence between infinitary term rewriting and term graph rewriting has been studied to some extent. However, this endeavour is impaired by the lack of an appropriate co...

  2. 7 CFR 28.522 - Explanatory terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Explanatory terms. 28.522 Section 28.522 Agriculture..., TESTING, AND STANDARDS Standards Application of Standards and Explanatory Terms § 28.522 Explanatory terms. (a) The term preparation is used to describe the degree of smoothness or roughness of the ginned...

  3. 30 CFR 745.12 - Terms.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Terms. 745.12 Section 745.12 Mineral Resources... STATE-FEDERAL COOPERATIVE AGREEMENTS § 745.12 Terms. Each cooperative agreement shall include: (a) Terms... administration of the cooperative agreement. (e) Terms requiring the State regulatory authority to...

  4. Long term stability of power systems

    Energy Technology Data Exchange (ETDEWEB)

    Kundur, P.; Gao, B. [Powertech Labs. Inc., Surrey, BC (Canada)

    1994-12-31

    Power system long term stability is still a developing subject. In this paper we provide our perspectives and experiences related to long term stability. The paper begins with the description of the nature of the long term stability problem, followed by the discussion of issues related to the modeling and solution techniques of tools for long term stability analysis. Cases studies are presented to illustrate the voltage stability aspect and plant dynamics aspect of long term stability. (author) 20 refs., 11 figs.

  5. Refining search terms for nanotechnology

    Science.gov (United States)

    Porter, Alan L.; Youtie, Jan; Shapira, Philip; Schoeneck, David J.

    2008-05-01

    The ability to delineate the boundaries of an emerging technology is central to obtaining an understanding of the technology's research paths and commercialization prospects. Nowhere is this more relevant than in the case of nanotechnology (hereafter identified as "nano") given its current rapid growth and multidisciplinary nature. (Under the rubric of nanotechnology, we also include nanoscience and nanoengineering.) Past efforts have utilized several strategies, including simple term search for the prefix nano, complex lexical and citation-based approaches, and bootstrapping techniques. This research introduces a modularized Boolean approach to defining nanotechnology which has been applied to several research and patenting databases. We explain our approach to downloading and cleaning data, and report initial results. Comparisons of this approach with other nanotechnology search formulations are presented. Implications for search strategy development and profiling of the nanotechnology field are discussed.

  6. Refining search terms for nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Porter, Alan L. [Georgia Institute of Technology (United States); Youtie, Jan [Georgia Institute of Technology, Enterprise Innovation Institute (United States)], E-mail: jan.youtie@innovate.gatech.edu; Shapira, Philip [Georgia Institute of Technology (United States); Schoeneck, David J. [Search Technology, Inc. (United States)

    2008-05-15

    The ability to delineate the boundaries of an emerging technology is central to obtaining an understanding of the technology's research paths and commercialization prospects. Nowhere is this more relevant than in the case of nanotechnology (hereafter identified as 'nano') given its current rapid growth and multidisciplinary nature. (Under the rubric of nanotechnology, we also include nanoscience and nanoengineering.) Past efforts have utilized several strategies, including simple term search for the prefix nano, complex lexical and citation-based approaches, and bootstrapping techniques. This research introduces a modularized Boolean approach to defining nanotechnology which has been applied to several research and patenting databases. We explain our approach to downloading and cleaning data, and report initial results. Comparisons of this approach with other nanotechnology search formulations are presented. Implications for search strategy development and profiling of the nanotechnology field are discussed.

  7. Business English in Practical Terms

    Directory of Open Access Journals (Sweden)

    Slavica Čepon

    2015-10-01

    Full Text Available The article is an attempt to look at the reality of teaching English for Business Purposes (EBP/ Business English (BE from a practical point of view. It approaches the term BE as if through a funnel with English as an International Language (EIL at the top, English Language Teaching/General English (ELT/GE as its sloping sides, English as a Foreign Language (EFL/English as a Second Language (ESL at the top of the funnel's narrow tube, and English for Specific Purposes (ESP at the very bottom, just above where BE, one of its main arms is placed. Special emphasis is laid on key distinctions between BE and ELT/GE, the function of BE teachers and the variety of roles that they assume in BE, on BE teachers as connoisseurs of specialist business expertise, and the importance of carrying out needs analysis as it brings to light some very important information about learners of BE.

  8. A Short Term Analogue Memory

    DEFF Research Database (Denmark)

    Shah, Peter Jivan

    1992-01-01

    A short term analogue memory is described. It is based on a well-known sample-hold topology in which leakage currents have been minimized partly by circuit design and partly by layout techniques. Measurements on a test chip implemented in a standard 2.4 micron analogue CMOS process show a droop...... rate of 0.075mV per second with a 1pF hold capacitor. This is equivalent to a retention time of approximately 1½ minute with 10 bits accuracy, assuming a full scale of +/-3.5V. It is expected that this can be improved by more than an order of magnitude by improving the layout of the hold capacitor...

  9. Standartization and Terminography of New Construction Terms

    Directory of Open Access Journals (Sweden)

    Zofija Babickienė

    2011-06-01

    Full Text Available The past ten year period showed the occurance of a great number of new construction terms in the Lithua- nian language. Thus it is necessary to collect and systematize construction terms, terminoids, quasi-terms and standardize them from the point of view of the Standard Lithuanian Language taking into account both logic and terminology requirements. This article deals with modern construction terms from the point of view of the Standard Lithuanian Language including newest data bases saving all actual information on them. The reseach showed that The Dictionary of Construction Terms (2003 ought to be included into The Lithuanian language Term Bank (http://terminai.vlkk.lt. It is necessary to be done for the following reasons. Firstly, because of the creation and standartization as well as sistematization process of new construction terms. Secondly, for the development of continuous scientific discusion and successful professional education. It was established that a certain number of construction terms from the point of view of the Standard Lithuanian Language should be included into new Dictionary of Construction Terms as well as into Term Bank of the Lithuanian Republic. The terms analysed in the article are concerning basement types, pile types, construction joints, also details of walls, roofs, chimneys, construction materials and etc. The analysis showed how different morphological variants and undesirable synonymous terms occur. Finally, the analysis helped to identify that the informal terms mix with formal, standard terms and conclude in incorrect term usage.

  10. Eigenvalues properties of terms correspondences matrix

    Science.gov (United States)

    Bondarchuk, Dmitry; Timofeeva, Galina

    2016-12-01

    Vector model representations of text documents are widely used in the intelligent search. In this approach a collection of documents is represented in the form of the term-document matrix, reflecting the frequency of terms. In the latent semantic analysis the dimension of the vector space is reduced by the singular value decomposition of the term-document matrix. Authors use a matrix of terms correspondences, reflecting the relationship between the terms, to allocate a semantic core and to obtain more simple presentation of the documents. With this approach, reducing the number of terms is based on the orthogonal decomposition of the matrix of terms correspondences. Properties of singular values of the term-document matrix and eigenvalues of the matrix of terms correspondences are studied in the case when documents differ substantially in length.

  11. Measurement of global and local resonance terms

    CERN Document Server

    Tomás, R; Calaga, R; Fischer, W; Franchi, A; Rumolo, Giovanni

    2005-01-01

    Recently, resonance driving terms were successfully measured in the CERN SPS and the BNL RHIC from the Fourier spectrum of beam position monitor (BPM) data. Based on these measurements a new analysis has been derived to extract truly local observables from BPM data. These local observables are called local resonance terms since they share some similarities with the global resonance terms. In this paper we derive these local terms analytically and present experimental measurements of sextupolar global and local resonance terms in RHIC. Nondestructive measurements of these terms using ac dipoles are also presented.

  12. Onboard Short Term Plan Viewer

    Science.gov (United States)

    Hall, Tim; LeBlanc, Troy; Ulman, Brian; McDonald, Aaron; Gramm, Paul; Chang, Li-Min; Keerthi, Suman; Kivlovitz, Dov; Hadlock, Jason

    2011-01-01

    Onboard Short Term Plan Viewer (OSTPV) is a computer program for electronic display of mission plans and timelines, both aboard the International Space Station (ISS) and in ISS ground control stations located in several countries. OSTPV was specifically designed both (1) for use within the limited ISS computing environment and (2) to be compatible with computers used in ground control stations. OSTPV supplants a prior system in which, aboard the ISS, timelines were printed on paper and incorporated into files that also contained other paper documents. Hence, the introduction of OSTPV has both reduced the consumption of resources and saved time in updating plans and timelines. OSTPV accepts, as input, the mission timeline output of a legacy, print-oriented, UNIX-based program called "Consolidated Planning System" and converts the timeline information for display in an interactive, dynamic, Windows Web-based graphical user interface that is used by both the ISS crew and ground control teams in real time. OSTPV enables the ISS crew to electronically indicate execution of timeline steps, launch electronic procedures, and efficiently report to ground control teams on the statuses of ISS activities, all by use of laptop computers aboard the ISS.

  13. Gratitude in Long Term Care

    Directory of Open Access Journals (Sweden)

    Brooke Abrams Sunding

    2015-04-01

    Full Text Available An exploratory study was conducted to examine the effectiveness of a group gratitude intervention with 29 permanent residents at a long term care/skilled nursing facility in improving elder mood, behavior and well- being over a 3 week time period. The sample included individuals diagnosed with dementia, other cognitive impairment, major depressive disorder, insomnia and generalized anxiety disorder. The gratitude intervention consisted of asking elders to share what they are thankful for at the dinner table each day. Measures included the Elder Well Being Scale and The Dinner Rating Scale. On both measures, higher scores indicated better functioning. To test the hypothesis that post treatment elder well-being will be significantly higher than pretreatment elder well-being ratings, a one-way ANOVA was conducted. Post-hoc tests revealed a statistically significant increase in Elder Well Being Scale scores. An ANOVA of comparing Dinner Ratings demonstrated a nonsignificant increase over the 3 week experiment. Implications are discussed.

  14. Long short-term memory.

    Science.gov (United States)

    Hochreiter, S; Schmidhuber, J

    1997-11-15

    Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient-based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O(1). Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.

  15. Asthma Medicines: Long-Term Control

    Science.gov (United States)

    ... Size Email Print Share Asthma Medicines: Long-term Control Page Content Article Body Corticosteroids Synthetic versions of ... form, they are used exclusively for long-term control; they are not very effective for acute symptoms. ...

  16. 16 CFR 500.2 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... legislature, but shall not include exports to foreign countries. (h) The term principal display panel means... practical importance. (k) The term customary inch/pound refers to units belonging to the system of...

  17. Unification and Matching on Compressed Terms

    CERN Document Server

    Gascón, Adrià; Schmidt-Schauß, Manfred

    2010-01-01

    Term unification plays an important role in many areas of computer science, especially in those related to logic. The universal mechanism of grammar-based compression for terms, in particular the so-called Singleton Tree Grammars (STG), have recently drawn considerable attention. Using STGs, terms of exponential size and height can be represented in linear space. Furthermore, the term representation by directed acyclic graphs (dags) can be efficiently simulated. The present paper is the result of an investigation on term unification and matching when the terms given as input are represented using different compression mechanisms for terms such as dags and Singleton Tree Grammars. We describe a polynomial time algorithm for context matching with dags, when the number of different context variables is fixed for the problem. For the same problem, NP-completeness is obtained when the terms are represented using the more general formalism of Singleton Tree Grammars. For first-order unification and matching polynom...

  18. Long term complications after radical cystoprostatectomy with ...

    African Journals Online (AJOL)

    Long term complications after radical cystoprostatectomy with orthotopic diversion in male ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING ... Objective: To evaluate the long-term outcomes beyond 1 year, both ...

  19. Prognostic indicators influencing short term outcomes among ...

    African Journals Online (AJOL)

    Prognostic indicators influencing short term outcomes among operated head injury patients ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... indicators for short term outcomes in operated head injury patients at KCMC.

  20. Information, polarization and term length in democracy

    DEFF Research Database (Denmark)

    Schultz, Christian

    2008-01-01

    This paper considers term lengths in a representative democracy where the political issue divides the population on the left-right scale. Parties are ideologically different and better informed about the consequences of policies than voters are. A short term length makes the government more accou...... the uncertainty is large and parties are not very polarized. Partisan voters always prefer a long term length. When politicians learn while in office a long term length becomes more attractive for swing voters....

  1. Anticipating Long-Term Stock Market Volatility

    OpenAIRE

    Conrad, Christian; Loch, Karin

    2012-01-01

    We investigate the relationship between long-term U.S. stock market risks and the macroeconomic environment using a two component GARCH-MIDAS model. Our results provide strong evidence in favor of counter-cyclical behavior of long-term stock market volatility. Among the various macro variables in our dataset the term spread, housing starts, corporate profits and the unemployment rate have the highest predictive ability for stock market volatility . While the term spread and housing starts are...

  2. Standartization and Terminography of New Construction Terms

    OpenAIRE

    Zofija Babickienė

    2011-01-01

    The past ten year period showed the occurance of a great number of new construction terms in the Lithua- nian language. Thus it is necessary to collect and systematize construction terms, terminoids, quasi-terms and standardize them from the point of view of the Standard Lithuanian Language taking into account both logic and terminology requirements. This article deals with modern construction terms from the point of view of the Standard Lithuanian Language including newest data base...

  3. Descriptive Morphology Terms For MAMA software

    Energy Technology Data Exchange (ETDEWEB)

    Ruggiero, Christy E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Porter, Reid B. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-05-21

    The table on the following pages lists a set of morphology terms for describing materials. We have organized these terms by categories. Software uses are welcome to suggest other terms that are needed to accurately describe materials. This list is intended as a initial starting point to generating a consensus terminology list.

  4. Long-term survival after perforated diverticulitis

    NARCIS (Netherlands)

    J. Vermeulen (Jan); M.P. Gosselink (Martijn Pieter); W.C.J. Hop (Wim); E. van der Harst (Erwin); B.E. Hansen (Bettina); G.H.H. Mannaerts (Guido); P-P. Coene (Peter Paul); W.F. Weidema (Wibo); J.F. Lange (Johan)

    2011-01-01

    textabstractAim: Short-term survival after emergency surgery for perforated diverticulitis is poor. Less is known about long-term survival. The aims of this study were to evaluate long-term survival after discharge from hospital and to identify factors associated with prognosis. Method: All patients

  5. 12 CFR 23.11 - Lease term.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Lease term. 23.11 Section 23.11 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY LEASING CEBA Leases § 23.11 Lease term. A CEBA Lease must have an initial term of not less than 90 days. A national bank may acquire...

  6. 30 CFR 281.19 - Lease term.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease term. 281.19 Section 281.19 Mineral... OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF Leasing Procedures § 281.19 Lease term. An OCS mineral lease for OCS minerals other than sand and gravel shall be for a primary term of not less than...

  7. Basic Color Terms in Estonian Sign Language

    Science.gov (United States)

    Hollman, Liivi; Sutrop, Urmas

    2011-01-01

    The article is written in the tradition of Brent Berlin and Paul Kay's theory of basic color terms. According to this theory there is a universal inventory of eleven basic color categories from which the basic color terms of any given language are always drawn. The number of basic color terms varies from 2 to 11 and in a language having a fully…

  8. Short-term managerial contracts facilitate cartels

    NARCIS (Netherlands)

    Han, M.A.

    2010-01-01

    This paper shows how a series of commonly observed short-term CEO employment contracts improves cartel stability compared to a long-term contract. When a manager’s short-term appointment is renewed if and only if the firm hits a certain profit target, then (a) defection from collusion results in sup

  9. Seri Dictionary: People and Kinship Terms.

    Science.gov (United States)

    Moser, Mary B.; Marlett, Stephen A.

    A subset of a Seri-English bilingual dictionary (in preparation) is presented that includes terms referring to people, kinship terms, and verbs closely related to them. This version includes an English-to-Seri dictionary with 61 basic terms and variants, and a Seri dictionary with both Spanish and English glosses. It uses a practical orthography…

  10. 36 CFR 13.188 - Permit terms.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Permit terms. 13.188 Section....188 Permit terms. The Superintendent shall allow for use and occupancy of a temporary facility only to... Superintendent may also establish permit terms that: (a) Limit use to a specified period, not to exceed...

  11. 7 CFR 948.101 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 948.101 Section 948.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulations General § 948.101 Terms. The terms used in this subpart shall have the same meaning as when...

  12. 7 CFR 917.103 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 917.103 Section 917.103 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Rules and Regulations Definitions § 917.103 Terms. All other terms used in this subpart shall have...

  13. 7 CFR 959.101 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 959.101 Section 959.101 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulations General § 959.101 Terms. The terms used in this subpart shall have the same meaning as when...

  14. 7 CFR 4279.126 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Loan terms. 4279.126 Section 4279.126 Agriculture... Loan terms. (a) The maximum repayment for loans on real estate will not exceed 30 years; machinery and... or 15 years, whichever is less; and working capital repayment will not exceed 7 years. The term for...

  15. 42 CFR 442.2 - Terms.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Terms. 442.2 Section 442.2 Public Health CENTERS... MENTALLY RETARDED General Provisions § 442.2 Terms. In this part— Facility refers to a nursing facility... discharged or had voluntarily left the facility. The term does not include the following: (a) Individuals...

  16. 10 CFR 110.50 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Terms. 110.50 Section 110.50 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL License Terms and Related Provisions § 110.50 Terms. (a) General and specific licenses. (1) Each license is subject to all...

  17. 7 CFR 4274.320 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Loan terms. 4274.320 Section 4274.320 Agriculture... (IRP) § 4274.320 Loan terms. (a) No loan to an intermediary shall be extended for a period exceeding 30... revolving fund will be scheduled for repayment over a term negotiated by the intermediary and...

  18. 13 CFR 500.204 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan terms. 500.204 Section 500... GUARANTEED LOAN PROGRAM Oil and Gas Guaranteed Loans § 500.204 Loan terms. (a) All loans guaranteed under the... United States with remaining periods of maturity comparable to the term of the loan sought to...

  19. 30 CFR 755.12 - Terms.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Terms. 755.12 Section 755.12 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR INDIAN LANDS PROGRAM TRIBAL-FEDERAL INTERGOVERNMENTAL AGREEMENTS § 755.12 Terms. The terms in each...

  20. 7 CFR 966.112 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 966.112 Section 966.112 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulations Definitions § 966.112 Terms. Terms used in this subpart shall have the same meaning as when...

  1. 49 CFR 260.9 - Loan terms.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Loan terms. 260.9 Section 260.9 Transportation... FINANCING PROGRAM Overview § 260.9 Loan terms. The maximum repayment period for direct loans and guaranteed... equal to the rate on Treasury securities of a similar term. In general, the financial...

  2. 7 CFR 946.102 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 946.102 Section 946.102 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulations Definitions § 946.102 Terms. Terms used in this subpart shall have the same meaning as set...

  3. 7 CFR 2201.19 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Loan terms. 2201.19 Section 2201.19 Agriculture... TELEVISION LOAN GUARANTEE PROGRAM-PROGRAM REGULATIONS Loan Guarantees § 2201.19 Loan terms. (a) All Loans... comparable maturity. (2) Have terms that, in the judgment of the Board, are consistent in material...

  4. 36 CFR 13.164 - Permit terms.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Permit terms. 13.164 Section... PARK SYSTEM UNITS IN ALASKA Cabins Cabin Use for Subsistence Purposes § 13.164 Permit terms. The Superintendent shall, among other conditions, establish terms of a permit that: (a) Allow for use and...

  5. 7 CFR 947.112 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 947.112 Section 947.112 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... § 947.112 Terms. Terms used in this subpart shall have the same meaning as when used in said...

  6. 10 CFR 611.107 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Loan terms. 611.107 Section 611.107 Energy DEPARTMENT OF... Direct Loan Program § 611.107 Loan terms. (a) All loans provided under this part shall be due and payable... priority in, such Security as provided for within the terms and conditions of the Loan Documents....

  7. 7 CFR 927.100 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 927.100 Section 927.100 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... and Regulations Definitions § 927.100 Terms. Each term used in this subpart shall have the...

  8. 7 CFR 58.159 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Terms. 58.159 Section 58.159 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections... Plants Approved for USDA Inspection and Grading Service 1 Explanation of Terms § 58.159 Terms. (a)...

  9. 7 CFR 945.112 - Terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Terms. 945.112 Section 945.112 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Rules and Regulations Definitions § 945.112 Terms. Terms...

  10. 13 CFR 400.204 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Loan terms. 400.204 Section 400... PROGRAM Steel Guarantee Loans § 400.204 Loan terms. (a) All loans guaranteed under the Program shall be... States with remaining periods of maturity comparable to the term of the loan sought to be guaranteed....

  11. 14 CFR 1300.15 - Loan terms.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Loan terms. 1300.15 Section 1300.15....15 Loan terms. (a) A loan guaranteed under the program shall be due and payable in full no later than... collateral, other loan terms, and current average yields on outstanding obligations of the United States...

  12. Basic Color Terms in Estonian Sign Language

    Science.gov (United States)

    Hollman, Liivi; Sutrop, Urmas

    2011-01-01

    The article is written in the tradition of Brent Berlin and Paul Kay's theory of basic color terms. According to this theory there is a universal inventory of eleven basic color categories from which the basic color terms of any given language are always drawn. The number of basic color terms varies from 2 to 11 and in a language having a fully…

  13. 7 CFR 51.892 - Color terms.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Color terms. 51.892 Section 51.892 Agriculture... Standards for Grades of Table Grapes (European or Vinifera Type) 1 Definitions § 51.892 Color terms. The color terms well colored, reasonably well colored, and fairly well colored are defined in Table...

  14. 16 CFR 502.2 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... and customary and regular when used with the term price means the price at which a consumer commodity..., package, label, person, commerce, principal display panel, and random package have the same meaning as those terms are defined under part 500 of this chapter. (b) The term packager and labeler means any...

  15. 7 CFR 201.2 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... specific characteristics. (hh) Single cross. The term “single cross” means the first generation hybrid...) Hybrid. The term “hybrid” applied to kinds or varieties of seed means the first generation seed of a... variety names. (z) Processing. For the purpose of section 203 (b)(2)(C) of the act the term “processing...

  16. Surface mount technology terms and concepts

    CERN Document Server

    Zarrow, Phil

    1997-01-01

    In today's fast-paced world of technology, keeping up with new terms and concepts can be quite a challenge. Surface Mount Technology Terms and Concepts is an invaluable reference containing over 1000 terms and definitions used in the SMT field. Each term is followed by a paragraph or two explaining the meaning and how it fits into the surface mount industry. The easy lookup and concise explanations make it ideal for those starting out in the field as well as professionals already involved in surface mount design and assembly.Glossary of over 1000 surface mount technology terms

  17. A finiteness structure on resource terms

    CERN Document Server

    Ehrhard, Thomas

    2010-01-01

    In our paper "Uniformity and the Taylor expansion of ordinary lambda-terms" (with Laurent Regnier), we studied a translation of lambda-terms as infinite linear combinations of resource lambda-terms, from a calculus similar to Boudol's lambda-calculus with resources and based on ideas coming from differential linear logic and differential lambda-calculus. The good properties of this translation wrt. beta-reduction were guaranteed by a coherence relation on resource terms: normalization is "linear and stable" (in the sense of the coherence space semantics of linear logic) wrt. this coherence relation. Such coherence properties are lost when one considers non-deterministic or algebraic extensions of the lambda-calculus (the algebraic lambda-calculus is an extension of the lambda-calculus where terms can be linearly combined). We introduce a "finiteness structure" on resource terms which induces a linearly topologized vector space structure on terms and prevents the appearance of infinite coefficients during redu...

  18. Focusing on Short-Term Achievement Gains Fails to Produce Long-Term Gains

    Science.gov (United States)

    Grissmer, David W.; Ober, David R.; Beekman, John A.

    2014-01-01

    The short-term emphasis engendered by No Child Left Behind (NCLB) has focused research predominantly on unraveling the complexities and uncertainties in assessing short-term results, rather than developing methods and assessing results over the longer term. In this paper we focus on estimating long-term gains and address questions important to…

  19. Short-term and long-term deflection of reinforced hollow core ...

    African Journals Online (AJOL)

    Short-term and long-term deflection of reinforced hollow core concrete slab systems. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... For the prediction of the long-term deflection, a measured ratio of long-term ...

  20. Neutrino quantum kinetic equations: The collision term

    Science.gov (United States)

    Blaschke, Daniel N.; Cirigliano, Vincenzo

    2016-08-01

    We derive the collision term relevant for neutrino quantum kinetic equations in the early universe and compact astrophysical objects, displaying its full matrix structure in both flavor and spin degrees of freedom. We include in our analysis neutrino-neutrino processes, scattering and annihilation with electrons and positrons, and neutrino scattering off nucleons (the latter in the low-density limit). After presenting the general structure of the collision terms, we take two instructive limiting cases. The one-flavor limit highlights the structure in helicity space and allows for a straightforward interpretation of the off-diagonal entries in terms of the product of scattering amplitudes of the two helicity states. The isotropic limit is relevant for studies of the early universe: in this case the terms involving spin coherence vanish and the collision term can be expressed in terms of two-dimensional integrals, suitable for computational implementation.

  1. Neutrino Quantum Kinetic Equations: The Collision Term

    CERN Document Server

    Blaschke, Daniel N

    2016-01-01

    We derive the collision term relevant for neutrino quantum kinetic equations in the early universe and compact astrophysical objects, displaying its full matrix structure in both flavor and spin degrees of freedom. We include in our analysis neutrino-neutrino processes, scattering and annihilation with electrons and positrons, and neutrino scattering off nucleons (the latter in the low-density limit). After presenting the general structure of the collision terms, we take two instructive limiting cases. The one-flavor limit highlights the structure in helicity space and allows for a straightforward interpretation of the off-diagonal entries in terms of the product of scattering amplitudes of the two helicity states. The isotropic limit is relevant for studies of the early universe: in this case the terms involving spin coherence vanish and the collision term can be expressed in terms of two-dimensional integrals, suitable for computational implementation.

  2. Moduli Corrections to D-term Inflation

    CERN Document Server

    Brax, P; Davis, S C; De van Bruck, C; Jeannerot, R; Postma, M; Brax, Ph.; Davis, Stephen C.

    2007-01-01

    We present a D-term hybrid inflation model, embedded in supergravity with moduli stabilisation. Its novel features allow us to overcome the serious challenges of combining D-term inflation and moduli fields within the same string-motivated theory. One salient point of the model is the positive definite uplifting D-term arising from the moduli stabilisation sector. By coupling this D-term to the inflationary sector, we generate an effective Fayet-Iliopoulos term. Moduli corrections to the inflationary dynamics are also obtained. Successful inflation is achieved for a range of parameter values with spectral index compatible with the WMAP3 data. Cosmic D-term strings are also formed at the end of inflation; these are no longer BPS objects. The properties of the strings are studied.

  3. HTGR Mechanistic Source Terms White Paper

    Energy Technology Data Exchange (ETDEWEB)

    Wayne Moe

    2010-07-01

    The primary purposes of this white paper are: (1) to describe the proposed approach for developing event specific mechanistic source terms for HTGR design and licensing, (2) to describe the technology development programs required to validate the design methods used to predict these mechanistic source terms and (3) to obtain agreement from the NRC that, subject to appropriate validation through the technology development program, the approach for developing event specific mechanistic source terms is acceptable

  4. HOME LONG-TERM CARE IN POLAND

    Directory of Open Access Journals (Sweden)

    Ewa Kułagowska

    2011-06-01

    Full Text Available The considerable proportion of the elderly, the chronically ill and the disabled in community is an economic and organizational challenge for the state social policy. It requires a large, steadily increasing financing from the public funds and creating an optional care model to fulfill the needs of citizens and guarantee high quality services. Development of the long-term care is one of the problems to be solved. This paper presents: – a long-term care forms, organization and tasks; – a role of long-term care but particularly home longterm care to protect health in Poland; – problems related with home long-term care functioning.

  5. SOURCE TERMS FOR AVERAGE DOE SNF CANISTERS

    Energy Technology Data Exchange (ETDEWEB)

    K. L. Goluoglu

    2000-06-09

    The objective of this calculation is to generate source terms for each type of Department of Energy (DOE) spent nuclear fuel (SNF) canister that may be disposed of at the potential repository at Yucca Mountain. The scope of this calculation is limited to generating source terms for average DOE SNF canisters, and is not intended to be used for subsequent calculations requiring bounding source terms. This calculation is to be used in future Performance Assessment calculations, or other shielding or thermal calculations requiring average source terms.

  6. Short-term intercultural psychotherapy: ethnographic inquiry.

    Science.gov (United States)

    Seeley, Karen M

    2004-01-01

    This article examines the challenges specific to short-term intercultural treatments and recently developed approaches to intercultural treatments based on notions of cultural knowledge and cultural competence. The article introduces alternative approaches to short-term intercultural treatments based on ethnographic inquiry adapted for clinical practice. Such approaches allow clinicians conducting short-term intercultural treatments to foreground clients' indigenous conceptions of selfhood, mind, relationship, and emotional disturbance, and thus to more fully grasp their internal, interpersonal, and external worlds. This article demonstrates the uses of clinically adapted ethnographic inquiry in three short-term intercultural cases.

  7. Chinese Term Extraction Based on PAT Tree

    Institute of Scientific and Technical Information of China (English)

    ZHANG Feng; FAN Xiao-zhong; XU Yun

    2006-01-01

    A new method of automatic Chinese term extraction is proposed based on Patricia (PAT) tree. Mutual information is calculated based on prefix searching in PAT tree of domain corpus to estimate the internal associative strength between Chinese characters in a string. It can improve the speed of term candidate extraction largely compared with methods based on domain corpus directly. Common collocation suffix, prefix bank are constructed and term part of speech (POS) composing rules are summarized to improve the precision of term extraction. Experiment results show that the F-measure is 74.97 %.

  8. Long-term dynamics simulation: Modeling requirements

    Energy Technology Data Exchange (ETDEWEB)

    Morched, A.S.; Kar, P.K.; Rogers, G.J.; Morison, G.K. (Ontario Hydro, Toronto, ON (Canada))

    1989-12-01

    This report details the required performance and modelling capabilities of a computer program intended for the study of the long term dynamics of power systems. Following a general introduction which outlines the need for long term dynamic studies, the modelling requirements for the conduct of such studies is discussed in detail. Particular emphasis is placed on models for system elements not normally modelled in power system stability programs, which will have a significant impact in the long term time frame of minutes to hours following the initiating disturbance. The report concludes with a discussion of the special computational and programming requirements for a long term stability program. 43 refs., 36 figs.

  9. 7 CFR 1219.200 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH... subpart, the definitions of terms used in this subpart shall have the same meaning as the definitions of such terms which appear in Subpart A—Hass Avocado Promotion, Research, and Information Order of...

  10. An Evolving List of School Reform Terms.

    Science.gov (United States)

    Bermudez, Pedro R.; Lindahl, Lois T.

    1999-01-01

    Discusses educational reform efforts that will change the school culture and improve instructional programs and includes a list of terms that represent the language of school reform. Understanding these terms might serve to influence the change process in schools that are thinking about or are actually engaged in systemic reform initiatives.…

  11. Consequences of long-term hyperparathyroidism

    NARCIS (Netherlands)

    Graal, M B; Wolffenbuttel, B H

    1998-01-01

    We describe a young woman with long-term untreated hyperparathyroidism with a superimposed vitamin D deficiency and an extremely decreased bone mineral density that was complicated by a vertebral fracture. Despite pretreatment with intravenous pamidronate and short-term vitamin D supplementation, se

  12. 47 CFR 13.15 - License term.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false License term. 13.15 Section 13.15 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.15 License term... years from the date of issuance. (b) General Radiotelephone Operator Licenses, Restricted...

  13. 47 CFR 27.1212 - License term.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false License term. 27.1212 Section 27.1212... COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1212 License term. (a) BRS/EBS licenses shall be issued for a period of 10 years beginning with the date of grant. (b) An...

  14. New Cotton Trade Terms Flashed in China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    On May 8th, 2006, China Cotton Import Regulations-Cotton Purchase Contract and General Terms (Applicable to Non-Chinese Cotton Trade), short for China Cotton Association Terms (CCAT) was issued and put into practice, which was welcomed by both China and the countries who trade cotton with China.

  15. Query term suggestion in academic search

    NARCIS (Netherlands)

    Verberne, S.; Sappelli, M.; Kraaij, W.

    2014-01-01

    In this paper, we evaluate query term suggestion in the context of academic professional search. Our overall goal is to support scientists in their information seeking tasks. We set up an interactive search system in which terms are extracted from clicked documents and suggested to the user before e

  16. Virtual Models of Long-Term Care

    Science.gov (United States)

    Phenice, Lillian A.; Griffore, Robert J.

    2012-01-01

    Nursing homes, assisted living facilities and home-care organizations, use web sites to describe their services to potential consumers. This virtual ethnographic study developed models representing how potential consumers may understand this information using data from web sites of 69 long-term-care providers. The content of long-term-care web…

  17. 30 CFR 256.37 - Lease term.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Lease term. 256.37 Section 256.37 Mineral... IN THE OUTER CONTINENTAL SHELF Issuance of Leases § 256.37 Lease term. (a)(1) All oil and gas leases... unusually deep water or other unusually adverse conditions. (2) If your oil and gas lease is in water...

  18. Term breech delivery in The Netherlands

    NARCIS (Netherlands)

    Rietberg, C.C.

    2006-01-01

    The management of the term breech delivery has been a subject of discussion for many years. Only a few randomized trials had been performed on outcome in relation to the mode of delivery in case of breech position. In october 2000 the results of the Term Breech Trial (TBT) were published, in which w

  19. Long-Term Memory and Learning

    Science.gov (United States)

    Crossland, John

    2011-01-01

    The English National Curriculum Programmes of Study emphasise the importance of knowledge, understanding and skills, and teachers are well versed in structuring learning in those terms. Research outcomes into how long-term memory is stored and retrieved provide support for structuring learning in this way. Four further messages are added to the…

  20. Definitions of Health Terms: General Health

    Science.gov (United States)

    ... this page: https://medlineplus.gov/definitions/generalhealthdefinitions.html Definitions of Health Terms: General Health To use the sharing features ... healthy. You can start by learning these general health terms. Find more definitions on Fitness | General Health | Minerals | Nutrition | Vitamins Basal ...

  1. [Presentation of eponymous terms in forensic medicine].

    Science.gov (United States)

    Nečas, P; Hejna, P

    2012-04-01

    The phenomenon of eponymous terms used in forensic medicine is described in the paper. Their linguistic basis, advantages and disadvantages for specialists or wider circles is discussed. Their spread in various language discourses is mentioned. A list of the most important eponymous terms in forensic medicine is the papers focus.

  2. 16 CFR 303.1 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... that solicit ultimate consumers to purchase such textile products by mail, telephone, electronic mail... REGULATIONS UNDER THE TEXTILE FIBER PRODUCTS IDENTIFICATION ACT § 303.1 Terms defined. As used in this part, unless the context otherwise specifically requires: (a) The term Act means the Textile Fiber...

  3. From the history of the term 'exocentric'

    NARCIS (Netherlands)

    Noordegraaf, J.

    1989-01-01

    In this paper it is argued that it was not Leonard Bloomfield who introduced the term 'exocentric' into modern linguistic terminology. This term was already used by other linguists such as Karl Brugmann and Aleksander Aleksandrov, and one could say that Bloomfield just anglicized it. It might be the

  4. 7 CFR 29.12 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Terms defined. 29.12 Section 29.12 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.12 Terms defined. As used in this subpart and in all...

  5. 13 CFR 130.610 - General terms.

    Science.gov (United States)

    2010-01-01

    ... CFR 143 and applicable OMB Circulars. ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false General terms. 130.610 Section 130... § 130.610 General terms. Upon approval of the initial or renewal application, SBA will enter into...

  6. The grammatical versatility of taboo terms

    NARCIS (Netherlands)

    Napoli, Donna Jo; Hoeksema, Jack

    2009-01-01

    Taboo terms in certain English expressions and constructions are intensifiers, which have spread as a unit over time to various syntactic positions (Hoeksema & Napoli 2008). Here we look at the pragmatic coherence that has allowed such semantically disparate terms to be grammaticalized as a unit. We

  7. 28 CFR 94.13 - Terms.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Terms. 94.13 Section 94.13 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIME VICTIM SERVICES International Terrorism Victim Expense Reimbursement Program Introduction § 94.13 Terms. The first three provisions of 1 U.S.C. 1 (rules...

  8. 25 CFR 173.1 - Terms used.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Terms used. 173.1 Section 173.1 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER CONCESSIONS, PERMITS AND LEASES ON LANDS WITHDRAWN OR ACQUIRED IN CONNECTION WITH INDIAN IRRIGATION PROJECTS § 173.1 Terms used. When used in this...

  9. Query term suggestion in academic search

    NARCIS (Netherlands)

    Verberne, S.; Sappelli, M.; Kraaij, W.

    2014-01-01

    In this paper, we evaluate query term suggestion in the context of academic professional search. Our overall goal is to support scientists in their information seeking tasks. We set up an interactive search system in which terms are extracted from clicked documents and suggested to the user before

  10. From the history of the term 'exocentric'

    NARCIS (Netherlands)

    Noordegraaf, J.

    1989-01-01

    In this paper it is argued that it was not Leonard Bloomfield who introduced the term 'exocentric' into modern linguistic terminology. This term was already used by other linguists such as Karl Brugmann and Aleksander Aleksandrov, and one could say that Bloomfield just anglicized it. It might be the

  11. A Neumann Boundary Term for Gravity

    CERN Document Server

    Krishnan, Chethan

    2016-01-01

    The Gibbons-Hawking-York (GHY) boundary term makes the Dirichlet problem for gravity well defined, but no such general term seems to be known for Neumann boundary conditions. In this paper, we view Neumann {\\em not} as fixing the normal derivative of the metric ("velocity") at the boundary, but as fixing the functional derivative of the action with respect to the boundary metric ("momentum"). This leads directly to a new boundary term for gravity: the trace of the extrinsic curvature with a specific dimension-dependent coefficient. In three dimensions this boundary term reduces to a "one-half" GHY term noted in the literature previously, and we observe that our action translates precisely to the Chern-Simons action with no extra boundary terms. In four dimensions the boundary term vanishes, giving a natural Neumann interpretation to the standard Einstein-Hilbert action without boundary terms. We argue that in light of AdS/CFT, ours is a natural approach for defining a "microcanonical" path integral for gravit...

  12. Self-dual gravity with topological terms

    CERN Document Server

    Montesinos, M

    2001-01-01

    The canonical analysis of the (anti-) self-dual action for gravity supplemented with the (anti-) self-dual Pontrjagin term is carried out. The effect of the topological term is to add a `magnetic' term to the original momentum variable associated with the self-dual action leaving the Ashtekar connection unmodified. In the new variables, the Gauss constraint retains its form, while both vector and Hamiltonian constraints are modified. This shows, the contribution of the Euler and Pontrjagin terms is not the same as that coming from the term associated with the Barbero-Immirzi parameter, and thus the analogy between the theta-angle in Yang-Mills theory and the Barbero-Immirzi parameter of gravity is not appropriate.

  13. Capturing the semiotic relationship between terms

    Science.gov (United States)

    Hargood, Charlie; Millard, David E.; Weal, Mark J.

    2010-04-01

    Tags describing objects on the web are often treated as facts about a resource, whereas it is quite possible that they represent more subjective observations. Existing methods of term expansion expand terms based on dictionary definitions or statistical information on term occurrence. Here we propose the use of a thematic model for term expansion based on semiotic relationships between terms; this has been shown to improve a system's thematic understanding of content and tags and to tease out the more subjective implications of those tags. Such a system relies on a thematic model that must be made by hand. In this article, we explore a method to capture a semiotic understanding of particular terms using a rule-based guide to authoring a thematic model. Experimentation shows that it is possible to capture valid definitions that can be used for semiotic term expansion but that the guide itself may not be sufficient to support this on a large scale. We argue that whilst the formation of super definitions will mitigate some of these problems, the development of an authoring support tool may be necessary to solve others.

  14. Dynamical D-terms in supergravity

    Directory of Open Access Journals (Sweden)

    Valerie Domcke

    2015-02-01

    Full Text Available Most phenomenological models of supersymmetry breaking rely on nonzero F-terms rather than nonzero D-terms. An important reason why D-terms are often neglected is that it turns out to be very challenging to realize D-terms at energies parametrically smaller than the Planck scale in supergravity. As we demonstrate in this paper, all conventional difficulties may, however, be overcome if the generation of the D-term is based on strong dynamics. To illustrate our idea, we focus on a certain class of vector-like SUSY breaking models that enjoy a minimal particle content and which may be easily embedded into more complete scenarios. We are then able to show that, upon gauging a global flavor symmetry, an appropriate choice of Yukawa couplings readily allows to dynamically generate a D-term at an almost arbitrary energy scale. This includes in particular the natural and consistent realization of D-terms around, above and below the scale of grand unification in supergravity, without the need for fine-tuning of any model parameters. Our construction might therefore bear the potential to open up a new direction for model building in supersymmetry and early universe cosmology.

  15. The octapolic ellipsoidal term in magnetoencephalography

    Science.gov (United States)

    Dassios, George; Hadjiloizi, Demetra; Kariotou, Fotini

    2009-01-01

    The forward problem of magnetoencephalography (MEG) in ellipsoidal geometry has been studied by Dassios and Kariotou ["Magnetoencephalography in ellipsoidal geometry," J. Math. Phys. 44, 220 (2003)] using the theory of ellipsoidal harmonics. In fact, the analytic solution of the quadrupolic term for the magnetic induction field has been calculated in the case of a dipolar neuronal current. Nevertheless, since the quadrupolic term is only the leading nonvanishing term in the multipole expansion of the magnetic field, it contains not enough information for the construction of an effective algorithm to solve the inverse MEG problem, i.e., to recover the position and the orientation of a dipole from measurements of the magnetic field outside the head. For this task, the next multipole of the magnetic field is also needed. The present work provides exactly this octapolic contribution of the dipolar current to the expansion of the magnetic induction field. The octapolic term is expressed in terms of the ellipsoidal harmonics of the third degree, and therefore it provides the highest order terms that can be expressed in closed form using long but reasonable analytic and algebraic manipulations. In principle, the knowledge of the quadrupolic and the octapolic terms is enough to solve the inverse problem of identifying a dipole inside an ellipsoid. Nevertheless, a simple inversion algorithm for this problem is not yet known.

  16. Long-term outcomes after severe shock.

    Science.gov (United States)

    Pratt, Cristina M; Hirshberg, Eliotte L; Jones, Jason P; Kuttler, Kathryn G; Lanspa, Michael J; Wilson, Emily L; Hopkins, Ramona O; Brown, Samuel M

    2015-02-01

    Severe shock is a life-threatening condition with very high short-term mortality. Whether the long-term outcomes among survivors of severe shock are similar to long-term outcomes of other critical illness survivors is unknown. We therefore sought to assess long-term survival and functional outcomes among 90-day survivors of severe shock and determine whether clinical predictors were associated with outcomes. Seventy-six patients who were alive 90 days after severe shock (received ≥1 μg/kg per minute of norepinephrine equivalent) were eligible for the study. We measured 3-year survival and long-term functional outcomes using the Medical Outcomes Study 36-Item Short-Form Health Survey, the EuroQOL 5-D-3L, the Hospital Anxiety and Depression Scale, the Impact of Event Scale-Revised, and an employment instrument. We also assessed the relationship between in-hospital predictors and long-term outcomes. The mean long-term survival was 5.1 years; 82% (62 of 76) of patients survived, of whom 49 were eligible for follow-up. Patients who died were older than patients who survived. Thirty-six patients completed a telephone interview a mean of 5 years after hospital admission. The patients' Physical Functioning scores were below U.S. population norms (P shock had a high 3-year survival rate. Patients' long-term physical and psychological outcomes were similar to those reported for cohorts of less severely ill intensive care unit survivors. Anxiety and depression were relatively common, but only a few patients had symptoms of posttraumatic stress disorder. This study supports the observation that acute illness severity does not determine long-term outcomes. Even extremely critically ill patients have similar outcomes to general intensive care unit survivor populations.

  17. Differences in health status between long-term and short-term benzodiazepine users.

    OpenAIRE

    2002-01-01

    BACKGROUND: Despite generally accepted advice to keep treatment short, benzodiazepines are often prescibed for more than six months. Prevention of long-term benzodiazepine use could be facilitated by the utilisation of risk indicators for long-term use. However, the characteristics of long-term benzodiazepine users described in the literature are based on studies in which long-term users were compared with non-users. Thus these characteristics may be imprecise. AIM: To study the characteristi...

  18. 26 CFR 1.79-0 - Group-term life insurance-definitions of certain terms.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Group-term life insurance-definitions of certain....79-0 Group-term life insurance—definitions of certain terms. The following definitions apply for... policy of life insurance is “carried directly or indirectly” by an employer if— (a) The employer pays...

  19. Business Students' Choice of Short-Term or Long-Term Study Abroad Opportunities

    Science.gov (United States)

    Fitzsimmons, Stacey R.; Flanagan, David J.; Wang, Xiaodan

    2013-01-01

    Recent years have seen a proliferation of short-term study abroad opportunities. Although they are both supplementing and replacing semester-long study abroad programs, research has focused primarily on semester (long-term) programs. We draw on the theory of planned behavior (TPB) to explore factors that predict why students choose long-term and…

  20. Differences in health status between long-term and short-term benzodiazepine users.

    NARCIS (Netherlands)

    Zandstra, S.M.; Furer, J.W.; Lisdonk, E.H. van de; Bor, J.H.J.; Zitman, F.G.; Weel, C. van

    2002-01-01

    BACKGROUND: Despite generally accepted advice to keep treatment short, benzodiazepines are often prescibed for more than six months. Prevention of long-term benzodiazepine use could be facilitated by the utilisation of risk indicators for long-term use. However, the characteristics of long-term benz

  1. Respiratory distress of the term newborn infant.

    Science.gov (United States)

    Edwards, Martin O; Kotecha, Sarah J; Kotecha, Sailesh

    2013-03-01

    Respiratory distress is recognised as any signs of breathing difficulties in neonates. In the early neonatal period respiratory distress is common, occurring in up to 7% of newborn infants, resulting in significant numbers of term-born infants being admitted to neonatal units. Many risk factors are involved; the increasing number of term infants delivered by elective caesarean section has also increased the incidence. Additionally the risk decreases with each advancing week of gestation. At 37 weeks, the chances are three times greater than at 39-40 weeks gestation. Multiple conditions can present with features of respiratory distress. Common causes in term newborn infants include transient tachypnoea of the newborn, respiratory distress syndrome, pneumonia, meconium aspiration syndrome, persistent pulmonary hypertension of the neonate and pneumothorax. Early recognition of respiratory distress and initiation of appropriate treatment is important to ensure optimal outcomes. This review will discuss these common causes of respiratory distress in term-born infants.

  2. Fractional Regularization Term for Variational Image Registration

    Directory of Open Access Journals (Sweden)

    Rafael Verdú-Monedero

    2009-01-01

    Full Text Available Image registration is a widely used task of image analysis with applications in many fields. Its classical formulation and current improvements are given in the spatial domain. In this paper a regularization term based on fractional order derivatives is formulated. This term is defined and implemented in the frequency domain by translating the energy functional into the frequency domain and obtaining the Euler-Lagrange equations which minimize it. The new regularization term leads to a simple formulation and design, being applicable to higher dimensions by using the corresponding multidimensional Fourier transform. The proposed regularization term allows for a real gradual transition from a diffusion registration to a curvature registration which is best suited to some applications and it is not possible in the spatial domain. Results with 3D actual images show the validity of this approach.

  3. Long-Term Ownership by Industrial Foundations

    DEFF Research Database (Denmark)

    Børsting, Christa Winther; Kuhn, Johan Moritz; Poulsen, Thomas

    2016-01-01

    Short-termism has become a serious concern for businesses and policy makers and this has inspired a search for governance arrangement to promote long term decision making. In this paper we study a particularly long-term ownership structure, which is fairly common in Northern Europe, particularly...... in Denmark. Industrial foundations are independent legal entities without owners or members typically with the dual objective of preserving the company and using excess profits for charity. We use a unique Danish data set to examine the governance of foundation-owned companies. We show that they are long-term...... in several respects. Foundations hold on to their shares for longer. Foundation-owned companies replace managers less frequently. They have more conservative capital structures with less leverage. Their companies survive longer. Their business decisions appear to be more long term. This paper supports...

  4. Long Term Care Minimum Data Set (MDS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Long-Term Care Minimum Data Set (MDS) is a standardized, primary screening and assessment tool of health status that forms the foundation of the comprehensive...

  5. Implied terms in English and Romanian law

    Directory of Open Access Journals (Sweden)

    Stefan Dinu

    2015-12-01

    Full Text Available This study analyses the matter of implied terms from the point of view of both English and Romanian law. First, the introductory section provides a brief overview of implied terms, by defining this class of contractual clauses and by providing their general features. Second, the English law position is analysed, where it is generally recognised that a term may be implied in one of three manners, which are described in turn. An emp hasis is made on the Privy Council’s decision in Attorney General of Belize v Belize Telecom Ltd and its impact. Third, the Romanian law position is described, the starting point of the discussion being represented by the provisions of Article 1272 of the 2009 Civil Code. Fourth, the study ends by mentioning some points of comparison between the two legal systems in what concerns the approach towards implied terms.

  6. Long Term Care Minimum Data Set (MDS)

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Long-Term Care Minimum Data Set (MDS) is a standardized, primary screening and assessment tool of health status that forms the foundation of the comprehensive...

  7. Long-Term Care Ombudsman Program

    Science.gov (United States)

    ... Strategic Plan Federal Initiatives Career Opportunities Contact Us Administration on Aging (AoA) Long-Term Care Ombudsman Program ( ... Prevention HIV/AIDS Nutrition Services Oral Health Elder Justice & Adult Protective Services Elder Justice Coordinating Council Prevention ...

  8. SEMANTIC TERM BASED INFORMATION RETRIEVAL USING ONTOLOGY

    Directory of Open Access Journals (Sweden)

    J. Mannar Mannan

    2014-01-01

    Full Text Available Information Searching and retrieval is a challenging task in the traditional keyword based textual information retrieval system. In the growing information age, adding huge data every day the searching problem also augmented. Keyword based retrieval system returns bulk of junk document irrelevant to query. To address the limitations, this paper proposed query terms along with semantic terms for information retrieval using multiple ontology reference. User query sometimes reflects multiple domain of interest that persist us to collect semantically related ontologies. If no related ontology exists then WordNet ontology used to retrieve semantic terms related to query term. In this approach, classes on the ontology derived as semantic related text keywords, these keywords considered for rank the documents.

  9. Entanglement Temperature With Gauss-Bonnet Term

    CERN Document Server

    Pal, Shesansu Sekhar

    2015-01-01

    We compute the entanglement temperature using the first law-like of thermodynamics, $\\Delta E=T_{ent} \\Delta S_{EE}$, up to Gauss-Bonnet term in the Jacobson-Myers entropy functional in any arbitrary spacetime dimension. The computation is done when the entangling region is the geometry of a slab. We also show that such a Gauss-Bonnet term, which becomes a total derivative, when the co-dimension two hypersurface is four dimensional, does not contribute to the finite term in the entanglement entropy. We observe that the Weyl-squared term does not contribute to the entanglement entropy. It is important to note that the calculations are performed when the entangling region is very small and the energy is calculated using the normal Hamiltonian.

  10. Analyzing Short-Term Disability Benefits.

    Science.gov (United States)

    Houff, James N.; Wiatrowski, William J.

    1989-01-01

    The Bureau of Labour Statistics has combined data on sick leave and sickness and accident insurance. Results show that short-term disability benefits vary by length of service and between the private and public sectors. (Author)

  11. Inhomogeneous Universe Models with Varying Cosmological Term

    CERN Document Server

    Chimento, L P; Chimento, Luis P.; Pavon, Diego

    1998-01-01

    The evolution of a class of inhomogeneous spherically symmetric universe models possessing a varying cosmological term and a material fluid, with an adiabatic index either constant or not, is studied.

  12. Pituitary diseases : long-term clinical consequences

    NARCIS (Netherlands)

    Klaauw, Agatha Apolonia van der

    2008-01-01

    This thesis describes various studies during the long-term follow-up of patients after treatment for pituitary diseases. The focus of this thesis is acromegaly, growth hormone deficiency, sleep and quality of life. Various aspects are described.

  13. Horava gravity with mixed derivative terms

    CERN Document Server

    Colombo, Mattia; Sotiriou, Thomas P

    2014-01-01

    Horava gravity has been constructed so as to exhibit anisotropic scaling in the ultraviolet, as this renders the theory power-counting renormalizable. However, when coupled to matter, the theory has been shown to suffer from quadratic divergences. A way to cure these divergences is to add terms with both time and space derivatives. We consider this extended version of the theory in detail. We perform a perturbative analysis that includes all modes, determine the propagators and discuss how including mixed-derivative terms affects them. We also consider the Lifshitz scalar with mixed-derivative terms as a toy model for power counting arguments and discuss the influence of such terms on renormalizability.

  14. Long-term outcome of meniscectomy

    DEFF Research Database (Denmark)

    Roos, Ewa M.; Ostenberg, A; Roos, H;

    2001-01-01

    To describe the long-term influence of meniscectomy on pain, functional limitations, and muscular performance. To assess the effects of radiographic osteoarthritis (OA), gender and age on these outcomes in patients with meniscectomy....

  15. Entanglement temperature with Gauss–Bonnet term

    Directory of Open Access Journals (Sweden)

    Shesansu Sekhar Pal

    2015-09-01

    Full Text Available We compute the entanglement temperature using the first law-like of thermodynamics, ΔE=TentΔSEE, up to Gauss–Bonnet term in the Jacobson–Myers entropy functional in any arbitrary spacetime dimension. The computation is done when the entangling region is the geometry of a slab. We also show that such a Gauss–Bonnet term, which becomes a total derivative, when the co-dimension two hypersurface is four dimensional, does not contribute to the finite term in the entanglement entropy. We observe that the Weyl-squared term does not contribute to the entanglement entropy. It is important to note that the calculations are performed when the entangling region is very small and the energy is calculated using the normal Hamiltonian.

  16. Pituitary diseases : long-term clinical consequences

    NARCIS (Netherlands)

    Klaauw, Agatha Apolonia van der

    2008-01-01

    This thesis describes various studies during the long-term follow-up of patients after treatment for pituitary diseases. The focus of this thesis is acromegaly, growth hormone deficiency, sleep and quality of life. Various aspects are described.

  17. Perinatal brain damage : The term infant

    NARCIS (Netherlands)

    Hagberg, Henrik; David Edwards, A.; Groenendaal, Floris

    2016-01-01

    Perinatal brain injury at term is common and often manifests with neonatal encephalopathy including seizures. The most common aetiologies are hypoxic–ischaemic encephalopathy, intracranial haemorrhage and neonatal stroke. Besides clinical and biochemical assessment the diagnostic evaluation rely

  18. Observational constrains on a decaying cosmological term

    CERN Document Server

    Nakamura, R; Ichiki, K; Nakamura, Riou; Hashimoto, Masa-aki; Ichiki, Kiyotomo

    2006-01-01

    We investigate the evolution of a universe with a decaying cosmological term (vacuum energy) that is assumed to be a function of the scale factor. In this model, while the cosmological term increases to the early universe, the radiation energy density is lower than the model with the cosmological "constant". We find that the effects of the decaying cosmological term on the expansion rate at the redshift z<2 is negligible. However, the decrease in the radiation density affects on the thermal history of the universe; e.g. the photon decoupling occurs at higher $z$ compared to the case of the standard \\Lambda CDM model. As a consequence, a decaying cosmological term affects on the cosmic microwave background anisotropy. We show the angular power spectrum in D\\Lambda CDM model and compare with the Wilkinson Microwave Anisotropy Probe (WMAP) data.

  19. Language and terms to communicate mathematics

    Directory of Open Access Journals (Sweden)

    Gouthier Daniele

    2002-06-01

    Full Text Available Popularising mathematics requires a preliminary reflection on language and terms, the choice of which results from underlying dynamics. The aim of this article is to start an overall analysis of the conditions influencing this linguistic choice.

  20. The Legal Cause of Unfair Terms

    OpenAIRE

    Maximiliano Arango Grajales

    2016-01-01

    Unfair terms are outside the field of abuse. There’s not a potential risk of damage, there’s not an injury caused. Unfair terms belong to the field of the principle of equivalency of the contract. And through it, that the criterion of regulatory imbalance of the contract takes on meaning. The correction of such unfair clauses does not depend on weak parts or abuse but rather the existence of a breach of equivalence: an absence of consideration in the contract.

  1. Timber joints under long-term loading

    DEFF Research Database (Denmark)

    Feldborg, T.; Johansen, M.

    This report describes tests and results from stiffness and strength testing of splice joints under long-term loading. During two years of loading the spicimens were exposed to cyclically changing relative humidity. After the loading period the specimens were short-term tested. The connectors were...... integral nail-plates and nailed steel and plywood gussets. The report is intended for designers and researchers in timber engineering....

  2. SEMANTIC TERM BASED INFORMATION RETRIEVAL USING ONTOLOGY

    OpenAIRE

    2014-01-01

    Information Searching and retrieval is a challenging task in the traditional keyword based textual information retrieval system. In the growing information age, adding huge data every day the searching problem also augmented. Keyword based retrieval system returns bulk of junk document irrelevant to query. To address the limitations, this paper proposed query terms along with semantic terms for information retrieval using multiple ontology reference. User query sometimes reflects multiple ...

  3. Glossary of Software Engineering Laboratory terms

    Science.gov (United States)

    1983-01-01

    A glossary of terms used in the Software Engineering Laboratory (SEL) is given. The terms are defined within the context of the software development environment for flight dynamics at the Goddard Space Flight Center. A concise reference for clarifying the language employed in SEL documents and data collection forms is given. Basic software engineering concepts are explained and standard definitions for use by SEL personnel are established.

  4. Consequences of long-term hyperparathyroidism.

    Science.gov (United States)

    Graal, M B; Wolffenbuttel, B H

    1998-07-01

    We describe a young woman with long-term untreated hyperparathyroidism with a superimposed vitamin D deficiency and an extremely decreased bone mineral density that was complicated by a vertebral fracture. Despite pretreatment with intravenous pamidronate and short-term vitamin D supplementation, severe and long-standing hypocalcaemia ('hungry bone syndrome') developed after parathyroidectomy. We discuss the consequences of hyperparathyroidism, especially the effects on bone, the complications of parathyroidectomy and the possibilities of preoperative treatment with bisphosphonates.

  5. What are the differences between long-term, short-term, and working memory?

    OpenAIRE

    Cowan, Nelson

    2008-01-01

    In the recent literature there has been considerable confusion about the three types of memory: long-term, short-term, and working memory. This chapter strives to reduce that confusion and makes up-to-date assessments of these types of memory. Long- and short-term memory could differ in two fundamental ways, with only short-term memory demonstrating (1) temporal decay and (2) chunk capacity limits. Both properties of short-term memory are still controversial but the current literature is rath...

  6. Terms vs. Concepts - The Case of Weight

    Science.gov (United States)

    Taibu, Rex

    2017-01-01

    Terminological and conceptual issues surrounding the definition of scientific terms have bothered teachers [A] and students for many years. Some terms such as energy are not even usually defined, although they appear in different contexts of scientific communication, and others such as weight have debatable definitions, and for this reason the term weight is a great example to demonstrate general issues regarding terms and concepts. The term weight is defined in different ways, e.g., as the gravitational force or operationally as the force exerted by the body on its support. In an inertial situation, the magnitude of the gravitational force is equal to that of the support force. However, the two meanings are distinct when the object is in an accelerating situation (e.g., an accelerating elevator or on the surface of a rotating planet). Apart from these dichotomous definitions of weight, there are further language problems associated with each gravitational and operational definition of weight. This paper demonstrates these issues and asserts that arguing for which definition of weight is correct is not a viable approach to solve the language issue. The paper proposes an alternative route to deal with language issues facing weight and other related terms.

  7. Term-Dependent Confidence Normalisation for Out-of-Vocabulary Spoken Term Detection

    Institute of Scientific and Technical Information of China (English)

    Dong Wang; Javier Tejedor; Simon King; Joe Frankel

    2012-01-01

    An important component of a spoken term detection (STD) system involves estimating confidence measures of hypothesised detections.A potential problem of the widely used lattice-based confidence estimation,however,is that the confidence scores are treated uniformly for all search terms,regardless of how much they may differ in terms of phonetic or linguistic properties.This problem is particularly evident for out-of-vocabulary (OOV) terms which tend to exhibit high intra-term diversity. To address the impact of term diversity on confidence measures,we propose in this work a term-dependent normalisation technique which compensates for term diversity in confidence estimation.We first derive an evaluation-metric-oriented normalisation that optimises the evaluation metric by compensating for the diverse occurrence rates among terms,and then propose a linear bias compensation and a discriminative compensation to deal with the bias problem that is inherent in lattice-based confidence measurement and from which the Term Specific Threshold (TST) approach suffers.We tested the proposed technique on speech data from the multi-party meeting domain with two state-ofthe-art STD systems based on phonemes and words respectively.The experimental results demonstrate that the confidence normalisation approach leads to a significant performance improvement in STD,particularly for OOV terms with phonemebased systems.

  8. No-scale μ -term hybrid inflation

    Science.gov (United States)

    Wu, Lina; Hu, Shan; Li, Tianjun

    2017-03-01

    To solve the fine-tuning problem in μ -term hybrid inflation, we will realize the supersymmetry scenario with the TeV-scale supersymmetric particles and intermediate-scale gravitino from anomaly mediation, which can be consistent with the WMAP and Planck experiments. Moreover, we for the first time propose the μ -term hybrid inflation in no-scale supergravity. With four scenarios for the SU(3)_C× SU(2)_L× SU(2)_R× U(1)_{B-L} model, we show that the correct scalar spectral index n_s can be obtained, while the tensor-to-scalar ratio r is predicted to be tiny, about 10^{-10}-10^{-8}. Also, the SU(2)_R× U(1)_{B-L} symmetry breaking scale is around 10^{14} GeV, and all the supersymmetric particles except gravitino are around the TeV scale, while the gravitino mass is around 109-10^{10} GeV. Considering the complete potential terms linear in S, we for the first time show that the tadpole term, which is the key for such kind of inflationary models to be consistent with the observed scalar spectral index, vanishes after inflation. Thus, to obtain the μ term, we need to generate the supersymmetry breaking soft term A^{S Φ Φ '}_{κ } κ S Φ Φ ' due to A^{S Φ Φ '}_{κ }=0 in no-scale supergravity, where Φ and Φ ' are vector-like Higgs fields at high energy. We show that the proper A^{S Φ Φ '}_{κ } κ S Φ Φ ' term can be obtained in the M-theory inspired no-scale supergravity. We also point out that A^{S Φ Φ '}_{κ } around 700 GeV can be generated via the renormalization group equation running from string scale. We briefly comment on the supersymmetry phenomenological consequences as well.

  9. Long-Term Hearing Results After Ossiculoplasty.

    Science.gov (United States)

    Cox, Matthew D; Trinidade, Aaron; Russell, James Shep; Dornhoffer, John L

    2017-04-01

    To determine if the OOPS index is predictive of long-term hearing results after ossiculoplasty. Case series with retrospective chart review. Tertiary care otology practice. Adult and pediatric patients (3-88 years of age). Ossiculoplasty with cartilage tympanoplasty, with or without mastoidectomy. Primary outcome measures included short-term hearing results (pure-tone average air-bone gap [PTA-ABG] measured between 60 days and 1 year after surgery), long-term hearing results (PTA-ABG measured ≥5 years after surgery), and the rate of successful ABG closure to ≤20 dB. Secondary measures included the need for revision surgery, delayed tympanic membrane graft failure, worsening conductive hearing loss (after an initially satisfactory hearing result), and recurrence of cholesteatoma. There was no significant difference between adults and children for short-term hearing results (average post-op PTA-ABG was 18.9 dB vs. 19.8 dB, respectively; p = 0.544), long-term hearing results (average final PTA-ABG was 19.3 dB vs. 19.4 dB, respectively; p = 0.922), or rate of ABG closure to less than 20 dB (63.1% vs. 58.0%, p = 0.282). Spearman's rank-order correlation (ρ) identified a strong positive correlation between OOPS index score and average post-operative PTA-ABG (ρ = 0.983; p hearing outcomes in adult and pediatric patients undergoing ossiculoplasty in both the short term and the long term.

  10. Long-term associative learning predicts verbal short-term memory performance.

    Science.gov (United States)

    Jones, Gary; Macken, Bill

    2017-10-02

    Studies using tests such as digit span and nonword repetition have implicated short-term memory across a range of developmental domains. Such tests ostensibly assess specialized processes for the short-term manipulation and maintenance of information that are often argued to enable long-term learning. However, there is considerable evidence for an influence of long-term linguistic learning on performance in short-term memory tasks that brings into question the role of a specialized short-term memory system separate from long-term knowledge. Using natural language corpora, we show experimentally and computationally that performance on three widely used measures of short-term memory (digit span, nonword repetition, and sentence recall) can be predicted from simple associative learning operating on the linguistic environment to which a typical child may have been exposed. The findings support the broad view that short-term verbal memory performance reflects the application of long-term language knowledge to the experimental setting.

  11. What are the differences between long-term, short-term, and working memory?

    Science.gov (United States)

    Cowan, Nelson

    2008-01-01

    In the recent literature there has been considerable confusion about the three types of memory: long-term, short-term, and working memory. This chapter strives to reduce that confusion and makes up-to-date assessments of these types of memory. Long- and short-term memory could differ in two fundamental ways, with only short-term memory demonstrating (1) temporal decay and (2) chunk capacity limits. Both properties of short-term memory are still controversial but the current literature is rather encouraging regarding the existence of both decay and capacity limits. Working memory has been conceived and defined in three different, slightly discrepant ways: as short-term memory applied to cognitive tasks, as a multi-component system that holds and manipulates information in short-term memory, and as the use of attention to manage short-term memory. Regardless of the definition, there are some measures of memory in the short term that seem routine and do not correlate well with cognitive aptitudes and other measures (those usually identified with the term "working memory") that seem more attention demanding and do correlate well with these aptitudes. The evidence is evaluated and placed within a theoretical framework depicted in Fig. 1.

  12. Placenta previa and long-term morbidity of the term offspring.

    Science.gov (United States)

    Walfisch, Asnat; Beharier, Ofer; Shoham-Vardi, Ilana; Sergienko, Ruslan; Landau, Daniella; Sheiner, Eyal

    2016-08-01

    The long-term impact of placenta previa on term infants is unknown. We aimed to investigate whether abnormal placentation increases the risk for long-term morbidity of the term offspring. A population-based cohort study compared the incidence of long-term hospitalizations up to the age of 18 due to cardiovascular, endocrine, neurological, hematological, respiratory and urinary morbidity of children born at term in pregnancies diagnosed with placenta previa and those without. Deliveries occurred between the years 1991-2013 in a tertiary medical center. Multiple pregnancies, and fetal congenital malformations were excluded. Kaplan-Meier survival curves were used to compare cumulative morbidity incidence over time. A multivariable generalized estimating equation (GEE) logistic regression model analysis was used to control for confounders and for maternal clusters. During the study period 233,123 term deliveries met the inclusion criteria; 0.2% (n=502) of the children were born to mothers with placenta previa. During the follow-up period, children born to mothers with placenta previa did not have an increased risk for long-term cardiovascular, endocrine, hematological, neurological, respiratory, and urinary morbidity. Term offsprings of mothers diagnosed with placenta previa do not appear to be at an increased risk for long-term morbidity up to the age of 18. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  13. Short-term memory across eye blinks.

    Science.gov (United States)

    Irwin, David E

    2014-01-01

    The effect of eye blinks on short-term memory was examined in two experiments. On each trial, participants viewed an initial display of coloured, oriented lines, then after a retention interval they viewed a test display that was either identical or different by one feature. Participants kept their eyes open throughout the retention interval on some blocks of trials, whereas on others they made a single eye blink. Accuracy was measured as a function of the number of items in the display to determine the capacity of short-term memory on blink and no-blink trials. In separate blocks of trials participants were instructed to remember colour only, orientation only, or both colour and orientation. Eye blinks reduced short-term memory capacity by approximately 0.6-0.8 items for both feature and conjunction stimuli. A third, control, experiment showed that a button press during the retention interval had no effect on short-term memory capacity, indicating that the effect of an eye blink was not due to general motoric dual-task interference. Eye blinks might instead reduce short-term memory capacity by interfering with attention-based rehearsal processes.

  14. New Computer Terms in Bloggers’ Language

    Directory of Open Access Journals (Sweden)

    Vilija Celiešienė

    2012-06-01

    Full Text Available The article presents an analysis of new words in computer terminology that make their way to blogs and analyzes how the official neologisms and computer terms, especially the equivalents to barbarisms, are employed in everyday use. The article also discusses the ways of including the new computer terms into texts. The blogs on topics of information technology are the objects of the research. The analysis of the aforementioned blogs allowed highlighting certain trends in the use of new computer terms. An observation was made that even though the authors of the blogs could freely choose their writing style, they were not bound by the standards of literary language. Thus, their language was full of non-standard vocabulary; however, self-control regarding the language used could still be noticed. An interest in novelties of computer terminology and the tendency to accept some of the suggested new Lithuanian and loaned computer terms were noticed. When using the new words the bloggers frequently employed specific graphical elements and (or comments. The graphical elements were often chosen by bloggers to express their feelings of doubt regarding the suitability of the use of the suggested loanword. Attempting to explain the meaning of the new word to the readers the bloggers tended to post comments about the new computer terms.

  15. Impact of spontaneous fibroid expulsion of uterine leiomyoma on pregnancy outcome after uterine arteries embolization

    Directory of Open Access Journals (Sweden)

    Medvediev M.V.

    2015-09-01

    Full Text Available Uterine leiomyoma (UL is common benign tumor of female genitals. Uterine artery embolization (UAE is widely used method of organ-sparing UL treatment. Safe ty of this procedure for future fertility and labor is controversial. We present a case of pregnancy in woman who previously underwent uterine artery embolization. During 12-months’ follow-up period patient periodically noted vaginal di¬scharge. No signs of UL have been found on ultrasound in 12 months of follow-up. Normal pregnancy occurred 1.5 years after UAE procedure which ended in normal labor without complications. Most authors report increased risk of pregnancy complications such as postpartum hemorrhage, preterm delivery, malpresentation after UAE. Our point of view is that a lot of pregnancy complications are possibly associated with persistence of necrotic leiomyoma tissue in uterine wall after UAE. Presented case allowed to draw preliminary conclusions that complete disappearance of UL nodule after UAE could improve pregnancy outcomes.

  16. Treatment of uterine fibroids for abnormal uterine bleeding: myomectomy and uterine artery embolization.

    Science.gov (United States)

    Al-Mahrizi, Sharifa; Tulandi, Togas

    2007-12-01

    Uterine myoma is a common benign tumour in women and most cases do not require treatment. Excessive uterine bleeding is usually due to a submucous myoma or an intramural myoma that is encroaching into the uterine cavity. After eliminating endometrial malignancy, perimenopausal women could be managed expectantly or with gonadotrophin-releasing hormone agonist until menopause. Hysteroscopic myomectomy is highly effective in controlling menorrhagia that is related to submucous myoma. Concomitant endometrial ablation improves menorrhagia; however, the subsequent hysterectomy rate remains the same. For those with an intramural myoma, abdominal myomectomy results in good bleeding control. It could also be done by laparoscopic approach; however, the surgeon should have expertise in laparoscopic suturing and the uterine incision should be properly sutured. In women who have completed their family, hysterectomy remains the most effective treatment for excessive uterine bleeding. Compared with uterine artery embolization (UAE), it is associated with better improvement in pelvic pain. Nevertheless, UAE is a good alternative to hysterectomy.

  17. [Anti-Müllerian hormone serum levels in women with and without uterine fibroids].

    Science.gov (United States)

    Carranza-Lira, Sebastián; Bustamante-Mendoza, Jenifer Alejandra; Leaños-Miranda, Alfredo; Campos-Galicia, Inova; Estrada-Moscoso, Isaías; Chan-Verdugo, Rosario; Ramos-Godínez, María del Pilar; Moncada-Claudio, Guadalupe; Peña-Torres, Maria de Lourdes

    2013-12-01

    The etiology of uterine leiomyomatosis is multifactorial and it is unknown if a relation between anti-Müllerian hormone (hormona anti-mülleriana) and uterine leiomyomatosis exists. To determine the differences of hormona anti-mülleriana levels in women with and without uterine leiomyomatosis. 60 women were studied (30 with and 30 without uterine leiomyomatosis). The diagnosis was confirmed by histopathology. Both groups were paired by age and in all them serum levels of hormona antimülleriana were measured using ELISA, also estradiol and progesterone serum levels were determined. hormona anti-mülleriana-RII immunohistochemistry was done in healthy myometrium and in leiomyomas. The mean age between the groups didn't show statistical difference (41.8 +/- 5.6 years vs. 41.4 +/- 5.7 years). Also no differences were found in weight, height and body mass index. Serum levels of hormona antimülleriana were lower in those with leiomyomatosis [0.21 (0-10.4) ng/ml vs. 1.83 (0-6.38) ng/ml, p hormona antimülleriana receptor was no expressed neither in the healthy myometrium nor in the leiomyomas. Women with leiomyomatosis had lower hormona antimülleriana levels. More studies are needed to determine if a relation exists between hormona antimülleriana and uterine leiomyomas.

  18. Use of Cancer-Linked Fibroid Device Declines After FDA Warning

    Science.gov (United States)

    ... The report was published Aug. 23 in the Journal of the American Medical Association . For the study, Wright and colleagues collected ... Huntington Hospital, N.Y.; Aug. 23/30, 2016, Journal of the American Medical Association HealthDay Copyright (c) 2016 HealthDay . All rights ...

  19. Studying the effect of some factors on the high incidence of uterine fibroid in Libyan women

    Directory of Open Access Journals (Sweden)

    Fathia M. Ben Ashour

    2015-12-01

    Methods: The Factors implicated in this case are analyzed using questionnaire on a random patient sample (152 cases within (2010-2014 from the archive of Aljalaa hospital. Results: Results show that, UF could affect women in young ages and above 40 years as well (P = 0.14. Marital status and the race of the patients significantly affect the rate of UF. The number of UF increased among married and white women comparing with single one and black one (P = 0.00 respectively. UF cases in the women holding O+ blood group were significantly higher than other groups (P=0.00. The educated women exhibit significant decrease in the UF incidence compared with less education status (P=0.00. Both normal delivered mode women and those received contraception pills showed a significant high rate of UF comparing with caesarian cut and with non-treated group (P=0.00, respectively. Menorrhagia was significantly higher than abdominal pain and infertility. Recurrent and family history was invaluable in UF incidence. Its ratio was significantly higher among women with no previous history and who have no family history (P=0.00. Myomectomy was significantly different from other choices; trans-abdominal hysterectomy and others (P=0.00. Conclusions: According to our results, marital status, hormones disturbances, life style including stress factors, race and knowledge about the case are the most implicated causes in the incidence of the case. Further studies on the ultra-structural level (Model are needed to verify the possible role/s for genes. [Int J Reprod Contracept Obstet Gynecol 2015; 4(6.000: 1954-1960

  20. Measuring the volume of uterine fibroids using 2- and 3-dimensional ultrasound and comparison with histopathology.

    Science.gov (United States)

    Zivković, Nikica; Zivković, Kreiimir; Despot, Albert; Paić, Josip; Zelić, Ana

    2012-12-01

    The aim of this study was clinical testing of the reliability and usability of three-dimensional (3D) and two-dimensional (2D) ultrasound (US) technology. The ultimate aim and purpose of this study was to establish ultrasound methods, standards and protocols for determining the volume of any gynecologic organ or tumor. The study included 31 women in reproductive age and postmenopause. All patients were examined with a RIC 5-9 3D-endovaginal probe (4.3-7.5 MHz) on a Voluson 730 Pro ultrasound device. The volume of myomas was measured by using the existing 2D and 3D ultrasound methods on the above mentioned device. All patients underwent myomectomy or hysterectomy due to clinically and ultrasonographically diagnosed uterine myomas indicating operative intervention. After the operation, the pathologist determined the volume of removed myomas by measuring them in a gauge bowl containing water, i.e. using Archimedes' principle (lift), serving as the control group with histopathologic diagnosis. A total of 155 myoma volumes were processed on 2D display, 31 myoma volumes were preoperatively measured on 3D display and 31 myoma volumes were measured by the pathologist. The values of US measurements for each US method were expressed as mean value of all measurements of myoma volumes. Statistical processing of the results and Student's t-test for independent samples revealed that the 2nd examined US method (measuring of myoma by using an ellipse and the longer tumor diameter) and 4th examined US method (measuring of myoma by using the longer and shorter tumor diameters together with establishing their mean values) in 2D US technique, as well as the 6th examined US method in 3D US technique showed no significant measurement differences in comparison with control measurement in a gauge bowl containing water (p < 0.05), indicating acceptability of the US methods for verifying tumor volumes. The standard error in determining the volume of myomas by the above US methods varied between 15% and 25%, so it is concluded that these three methods can be used in clinical practice to determine tumor volumes, in this case uterine myomas. The 3D MultiPlane method proved to be the most reliable method of determining the volume of uterine myomas.

  1. pain control for uterine fibroid embolisation-an initial experience in ...

    African Journals Online (AJOL)

    East African Medical Journal Vol 88 No. 6 June 2011 .... nasal prongs and oxygen flow at 3litres/. • minute .... and devices used while facilitating the rapid recovery to keep the inpatient stay ... table 3 and none required additional pain control in.

  2. Semantic Features for Classifying Referring Search Terms

    Energy Technology Data Exchange (ETDEWEB)

    May, Chandler J.; Henry, Michael J.; McGrath, Liam R.; Bell, Eric B.; Marshall, Eric J.; Gregory, Michelle L.

    2012-05-11

    When an internet user clicks on a result in a search engine, a request is submitted to the destination web server that includes a referrer field containing the search terms given by the user. Using this information, website owners can analyze the search terms leading to their websites to better understand their visitors needs. This work explores some of the features that can be used for classification-based analysis of such referring search terms. We present initial results for the example task of classifying HTTP requests countries of origin. A system that can accurately predict the country of origin from query text may be a valuable complement to IP lookup methods which are susceptible to the obfuscation of dereferrers or proxies. We suggest that the addition of semantic features improves classifier performance in this example application. We begin by looking at related work and presenting our approach. After describing initial experiments and results, we discuss paths forward for this work.

  3. Terms of trade and Russian economic development

    Directory of Open Access Journals (Sweden)

    Georgy Idrisov

    2016-09-01

    Full Text Available The paper discusses economic development trends in Russia in late 2014 and 2015 and reviews the basic mechanisms of how changes in the terms of trade affect the economic development of countries from a historical perspective and with a particular focus on those changes in the Russian economy that occurred in late 2014 and 2015. The authors demonstrate that structural reforms aimed at diversification of production and exports are necessary for sustainable economic development, for social stability and for reducing the impact of variability in the terms of trade on the Russian economy. During periods of instability in the government agenda's measures for the real and financial sectors, it is necessary not only to compensate economic agents losses caused by changes in the terms of trade but also to improve the economic structure and to develop and enhance the stability of the financial markets.

  4. Long-term Multiwavelength Observations of Polars

    Science.gov (United States)

    Santana, Joshua; Mason, Paul A.

    2016-06-01

    Polars are cataclysmic variables with the highest magnetic field strengths (10-250 MG). Matter is accreted after being funneled by the strong magnetic field of the white dwarf. We perform a meta-study of multi-wavelength data of polars. Many polars have been observed in surveys, such as SDSS, 2MASS, ROSAT, just to name a few. Some polars have now been detected by the JVLA, part of an expanding class of radio CVs. A large subset of polars have long-term optical light curves from CRTS and AAVSO. We suggest that the long term light curves of polars display a variety of signature behaviors and may be grouped accordingly. Additional characteristics such a binary period, magnetic field strengths, X-ray properties, and distance estimates are examined in context with long-term observations.

  5. Nuclear Targeting Terms for Engineers and Scientists

    Energy Technology Data Exchange (ETDEWEB)

    St Ledger, John W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-02-01

    The Department of Defense has a methodology for targeting nuclear weapons, and a jargon that is used to communicate between the analysts, planners, aircrews, and missile crews. The typical engineer or scientist in the Department of Energy may not have been exposed to the nuclear weapons targeting terms and methods. This report provides an introduction to the terms and methodologies used for nuclear targeting. Its purpose is to prepare engineers and scientists to participate in wargames, exercises, and discussions with the Department of Defense. Terms such as Circular Error Probable, probability of hit and damage, damage expectancy, and the physical vulnerability system are discussed. Methods for compounding damage from multiple weapons applied to one target are presented.

  6. Variable cosmological term $\\Lambda(t)$

    CERN Document Server

    Socorro, J; Pimentel, Luis O

    2015-01-01

    We present the case of time-varying cosmological term $\\Lambda(t)$. The main idea arises by proposing that as in the cosmological constant case, the scalar potential is identified as $ V(\\phi)=2\\Lambda$, with $\\Lambda$ a constant, this identification should be kept even when the cosmological term has a temporal dependence, i.e., $ V(\\phi(t))=2\\Lambda(t)$. We Use the Lagrangian formalism for a scalar field $\\phi$ with standard kinetic energy and arbitrary potential $V(\\phi)$ and apply this model to the Friedmann-Robertson-Walker (FRW)cosmology. Exact solutions of the field equations are obtained by a special ansatz to solve the Einstein-Klein-Gordon equation and a particular potential for the scalar field and barotropic perfect fluid. We present the evolution on this cosmological term with different scenarios.

  7. Variable cosmological term \\varLambda(t)

    Science.gov (United States)

    Socorro, J.; D'oleire, M.; Pimentel, Luis O.

    2015-11-01

    We present the case of time-varying cosmological term \\varLambda(t). The main idea arises by proposing that as in the cosmological constant case, the scalar potential is identified as V(φ)=2\\varLambda, with \\varLambda a constant, this identification should be kept even when the cosmological term has a temporal dependence, i.e., V(φ(t))=2\\varLambda(t). We use the Lagrangian formalism for a scalar field φ with standard kinetic energy and arbitrary potential V(φ) and apply this model to the Friedmann-Robertson-Walker (FRW) cosmology. Exact solutions of the field equations are obtained by a special ansatz to solve the Einstein-Klein-Gordon equation and a particular potential for the scalar field and barotropic perfect fluid. We present the evolution on this cosmological term with different scenarios.

  8. Baby Skyrme models without a potential term

    CERN Document Server

    Ashcroft, Jennifer; Krusch, Steffen

    2015-01-01

    We develop a one-parameter family of static baby Skyrme models that do not require a potential term to admit topological solitons. This is a novel property as all currently known baby Skyrme models must contain a potential term in order to have stable soliton solutions, though the Skyrme model does not require this. Our new models satisfy an energy bound that is linear in terms of the topological charge and can be saturated in an extreme limit. They also satisfy a virial theorem that is shared by the Skyrme model. We calculate the solitons of our new models numerically and observe that their form depends significantly on the choice of parameter. In one extreme, we find compactons whilst at the other there is a scale invariant model in which solitons can be obtained exactly as solutions to a Bogomolny equation. We provide an initial investigation into these solitons and compare them with the baby Skyrmions of other models.

  9. Block TERM factorization of block matrices

    Institute of Scientific and Technical Information of China (English)

    SHE Yiyuan; HAO Pengwei

    2004-01-01

    Reversible integer mapping (or integer transform) is a useful way to realize Iossless coding, and this technique has been used for multi-component image compression in the new international image compression standard JPEG 2000. For any nonsingular linear transform of finite dimension, its integer transform can be implemented by factorizing the transform matrix into 3 triangular elementary reversible matrices (TERMs) or a series of single-row elementary reversible matrices (SERMs). To speed up and parallelize integer transforms, we study block TERM and SERM factorizations in this paper. First, to guarantee flexible scaling manners, the classical determinant (det) is generalized to a matrix function, DET, which is shown to have many important properties analogous to those of det. Then based on DET, a generic block TERM factorization,BLUS, is presented for any nonsingular block matrix. Our conclusions can cover the early optimal point factorizations and provide an efficient way to implement integer transforms for large matrices.

  10. Breech at term--mode of delivery?

    DEFF Research Database (Denmark)

    Krebs, L; Langhoff-Roos, J; Weber, T

    1995-01-01

    : Register-based cohort study of all (n = 15718) singleton term breech deliveries of non-malformed infants in Denmark 1982-1990. Process and outcome measures: mode of delivery, gestational age, birth weight, congenital malformations, intrapartum death, Apgar scores and early neonatal death. RESULTS: A total...... of 3247 (20.7%) term infants were delivered vaginally, 7106 (45.3%) by elective and 5356 (34.1%) by emergency cesarean section. Infants delivered vaginally and by emergency cesarean section had significantly higher rates of mortality (intrapartum and early neonatal death) and morbidity (low Apgar scores......BACKGROUND: The present study was designed to determine neonatal mortality and morbidity in non-malformed singleton term infants delivered in breech presentation and identify a possible correlation between outcome on the one hand and mode of delivery, parity and birth weight on the other. METHODS...

  11. On Strategies of Translating Chinese Characteristic Terms into English-Taking Chinese Economic Terms as Examples

    Institute of Scientific and Technical Information of China (English)

    Tsering Dekyi

    2016-01-01

    After the reform and opening up to the outside world, great changes have taken place in many fields like economy, poli-tics, and culture in China. In the field of economy, a multitude of new phenomena, new ideas and new things spring up continu-ously. At the same time, many Chinese characteristic terms reflecting these new things have been emerging. The creation of these terms requires the translators to provide accurate and idiomatic translation of them in time. The English translation of Chi-nese characteristic terms plays an important role not only in promoting Chinese characteristic socialist economy but also in deep-ening the understanding of Chinese economy for English readers. Therefore, this paper will analyze the features and translation obstacles of Chinese characteristic terms, then point out some practical guidelines and methods to solve the problems in translat-ing Chinese characteristic terms into English. This paper aims to improve the translation of Chinese Characteristic terms.

  12. Long-term follow-up study and long-term care of childhood cancer survivors

    Directory of Open Access Journals (Sweden)

    Hyeon Jin Park

    2010-04-01

    Full Text Available The number of long-term survivors is increasing in the western countries due to remarkable improvements in the treatment of childhood cancer. The long-term complications of childhood cancer survivors in these countries were brought to light by the childhood cancer survivor studies. In Korea, the 5-year survival rate of childhood cancer patients is approaching 70%; therefore, it is extremely important to undertake similar long-term follow-up studies and comprehensive long-term care for our population. On the basis of the experiences of childhood cancer survivorship care of the western countries and the current Korean status of childhood cancer survivors, long-term follow-up study and long-term care systems need to be established in Korea in the near future. This system might contribute to the improvement of the quality of life of childhood cancer survivors through effective intervention strategies.

  13. Long-term home care scheduling

    DEFF Research Database (Denmark)

    Gamst, Mette; Jensen, Thomas Sejr

    In several countries, home care is provided for certain citizens living at home. The long-term home care scheduling problem is to generate work plans spanning several days such that a high quality of service is maintained and the overall cost is kept as low as possible. A solution to the problem...... provides detailed information on visits and visit times for each employee on each of the covered days. We propose a branch-and-price algorithm for the long-term home care scheduling problem. The pricing problem generates one-day plans for an employee, and the master problem merges the plans with respect...

  14. The Legal Cause of Unfair Terms

    Directory of Open Access Journals (Sweden)

    Maximiliano Arango Grajales

    2016-01-01

    Full Text Available Unfair terms are outside the field of abuse. There’s not a potential risk of damage, there’s not an injury caused. Unfair terms belong to the field of the principle of equivalency of the contract. And through it, that the criterion of regulatory imbalance of the contract takes on meaning. The correction of such unfair clauses does not depend on weak parts or abuse but rather the existence of a breach of equivalence: an absence of consideration in the contract.

  15. [Fetal pain: immediate and long term consequences].

    Science.gov (United States)

    Houfflin Debarge, Véronique; Dutriez, Isabelle; Pusniak, Benoit; Delarue, Eléonore; Storme, Laurent

    2010-06-01

    Several situations are potentially painful for fetuses, such as malformations and invasive procedures. Nociceptive pathways are known to be functional at 26 weeks. Even if it is not possible to evaluate the fetal experience of pain, it is essential to examine its immediate and long-term consequences. As early as the beginning of the second trimester, hemodynamic and hormonal responses are observed following fetal nociceptive stimulation, In experimental studies, long-term changes have been noted in the corticotrop axis, subsequent responses to pain, and behavior after perinatal nociceptive stimulation.

  16. Keratoprosthesis: a long-term review.

    Science.gov (United States)

    Barnham, J J; Roper-Hall, M J

    1983-07-01

    A keratoprosthesis (KP), is an artificial cornea which is inserted into an opacified cornea in an attempt to restore useful vision or, less commonly, to make the eye comfortable in painful keratopathy. Results o a retrospective study of 35 patients, with 55 KP insertions, are reviewed with regard to visual acuity, length of time vision is maintained, retention time, and complication. Overall there were a number of long-term real successes, eith retention of the KP and maintenance of improved vision in eyes not amenable to conventional treatment. Careful long-term follow-up was needed, with further surgical procedures often being necessary.

  17. History of physical terms: ‘pressure’

    Science.gov (United States)

    Frontali, Clara

    2013-07-01

    Scientific terms drawn from common language are often charged with suggestions that may even be inconsistent with their restricted scientific meaning, thus posing didactic problems. The (non-linear) historical journey of the word ‘pressure’ is illustrated here through original quotations from Stevinus, Torricelli, Pascal, Boyle, Magalotti, Bernoulli and Dalton, in an attempt to follow the shift from the idea of a force to the modern understanding of the term as a state variable. The latter appears to have prevailed as a consequence of technological advances of the industrial revolution (Watt’s steam engine and indicator diagram) in their 19th century re-elaboration.

  18. Sportsman’s hernia? An ambiguous term

    Science.gov (United States)

    Dimitrakopoulou, Alexandra; Schilders, Ernest

    2016-01-01

    Groin pain is common in athletes. Yet, there is disagreement on aetiology, pathomechanics and terminology. A plethora of terms have been employed to explain inguinal-related groin pain in athletes. Recently, at the British Hernia Society in Manchester 2012, a consensus was reached to use the term inguinal disruption based on the pathophysiology while lately the Doha agreement in 2014 defined it as inguinal-related groin pain, a clinically based taxonomy. This review article emphasizes the anatomy, pathogenesis, standard clinical assessment and imaging, and highlights the treatment options for inguinal disruption. PMID:27026822

  19. The Term Innovation and its Front End

    DEFF Research Database (Denmark)

    Brem, Alexander

    2009-01-01

    Innovation is not just a very popular buzzword, but a very multi-faceted one as well. In this context, especially between different countries and continents, there are essential differences in terms and definitions of innovation and innovative activities, especially between Europe and Asia. Hence......, before the background of globalized economies, a common understanding is needed for successful future intercultural projects and appropriate management. Especially in scientific research, a first step should be made in this direction. Therefore, a comprehensive view of the term innovation and its...

  20. The Term Innovation and its Front End

    DEFF Research Database (Denmark)

    Brem, Alexander

    2009-01-01

    Innovation is not just a very popular buzzword, but a very multi-faceted one as well. In this context, especially between different countries and continents, there are essential differences in terms and definitions of innovation and innovative activities, especially between Europe and Asia. Hence......, before the background of globalized economies, a common understanding is needed for successful future intercultural projects and appropriate management. Especially in scientific research, a first step should be made in this direction. Therefore, a comprehensive view of the term innovation and its...

  1. Short Term Airing by Natural Ventilation

    DEFF Research Database (Denmark)

    Heiselberg, Per; Perino, M.

    2010-01-01

    principles is necessary. The present study analyses and presents the results of an experimental evaluation of airing performance in terms of ventilation characteristics, IAQ and thermal comfort. It includes investigations of the consequences of opening time, opening frequency, opening area and expected...... airflow rate, ventilation efficiency, thermal comfort and dynamic temperature conditions. A suitable laboratory test rig was developed to perform extensive experimental analyses of the phenomenon under controlled and repeatable conditions. The results showed that short-term window airing is very effective...... and can provide both acceptable IAQ and thermal comfort conditions in buildings....

  2. Near-Term Actions to Address Long-Term Climate Risk

    Science.gov (United States)

    Lempert, R. J.

    2014-12-01

    Addressing climate change requires effective long-term policy making, which occurs when reflecting on potential events decades or more in the future causes policy makers to choose near-term actions different than those they would otherwise pursue. Contrary to some expectations, policy makers do sometimes make such long-term decisions, but not as commonly and successfully as climate change may require. In recent years however, the new capabilities of analytic decision support tools, combined with improved understanding of cognitive and organizational behaviors, has significantly improved the methods available for organizations to manage longer-term climate risks. In particular, these tools allow decision makers to understand what near-term actions consistently contribute to achieving both short- and long-term societal goals, even in the face of deep uncertainty regarding the long-term future. This talk will describe applications of these approaches for infrastructure, water, and flood risk management planning, as well as studies of how near-term choices about policy architectures can affect long-term greenhouse gas emission reduction pathways.

  3. Magnetic resonance-guided focused ultrasound surgery for leiomyoma-associated infertility

    Science.gov (United States)

    Bouwsma, Esther V. A.; Gorny, Krzysztof R.; Hesley, Gina K.; Jensen, Jani R.; Peterson, Lisa G; Stewart, Elizabeth A.

    2017-01-01

    Objective To describe magnetic resonance-guided focused ultrasound surgery (FUS) as a treatment for a case of leiomyoma-associated infertility. Design Case report from a randomized clinical trial. Setting Academic medical center. Patient(s) A 37-year-old woman with known leiomyomas and a history of 18 months of home-inseminations from a known donor. Intervention(s) Magnetic resonance-guided FUS treatment of uterine fibroids, where the dominant fibroid distorted the uterine cavity. Main Outcome Measure(s) Pregnancy. Result(s) A viable intrauterine pregnancy, with a full-term vaginal delivery, was conceived after a single clomiphene citrate and intrauterine insemination cycle. Conclusion(s) The role of FUS for enhancement of fertility in women with nonhysteroscopically resectable uterine fibroids distorting the uterine cavity should be investigated further. PMID:21570071

  4. Transfinite reductions in orthogonal term rewriting systems

    NARCIS (Netherlands)

    J.R. Kennaway (Richard); J.W. Klop (Jan Willem); M.R. Sleep (Ronan); F.-J. de Vries (Fer-Jan)

    1991-01-01

    textabstractStrongly convergent reduction is the fundamental notion of reduction in infinitary orthogonal term rewriting systems (OTRSs). For these we prove the Transfinite Parallel Moves Lemma and the Compressing Lemma. Strongness is necessary as shown by counterexamples. Normal forms, which we

  5. 7 CFR 51.2 - Terms defined.

    Science.gov (United States)

    2010-01-01

    ... Definitions § 51.2 Terms defined. Words in the regulations in this part in the singular form shall be deemed.... “Federal-State Inspection Agency” means any State agency, business association or trade organization... plant. “Packing plant” means the premises, buildings, structures, and equipment including but...

  6. 75 FR 20561 - Patent Term Extension

    Science.gov (United States)

    2010-04-20

    ... Patent and Trademark Office Patent Term Extension ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its continuing effort to reduce... the Chief Information Officer, United States Patent and Trademark Office, P.O. Box 1450,...

  7. 78 FR 31885 - Patent Term Extension

    Science.gov (United States)

    2013-05-28

    ... Patent and Trademark Office Patent Term Extension ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and Trademark Office (USPTO), as part of its continuing effort to reduce...: Susan K. Fawcett, Records Officer, Office of the Chief Information Officer, United States Patent...

  8. Medium-Term Oil Market Report 2006

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    How much oil will the world consume in 2011? What role will OPEC play in global oil production? Will biofuels become an important part of the oil market? The International Energy Agencys (IEA) Medium-Term Oil Market Report tackles these questions, adopting a perspective that goes beyond the traditional short-term market analysis provided in the IEAs monthly Oil Market Report. Drawing on current futures curves and the investment threshold for upstream projects, the Medium-Term Oil Market Report analyses how global demand and supply balances may develop in the next five years. The forecasts look in detail at product demand and the supply potential from all the firmly planned individual upstream and downstream projects around the world. The results provide invaluable insights on vital issues such as surplus production capacity and product supply. The rapid pace of change in the oil market means that forecasts can become outdated very quickly. This interim update provides the opportunity to rebase the data and forecasts in the annual Medium-Term Oil Market Report and to discuss and analyse new issues affecting the oil industry. Policymakers, market analysts, energy experts and anyone interested in understanding and following trends in the oil market should find this report extremely useful.

  9. Guide to Sources: Term Paper Strategy.

    Science.gov (United States)

    White, Lucinda M.

    This two-page guide suggests an eight-step term paper research strategy for students using the Fogler Library at the University of Maine. The student is first guided to encyclopedias for overview articles with bibliographies, then directed to the card catalog; periodical indexes; and indexes for books, journal articles, and newspaper articles.…

  10. Long-term prevention of diabetic nephropathy

    DEFF Research Database (Denmark)

    Schjoedt, K J; Hansen, H P; Tarnow, L

    2008-01-01

    AIMS/HYPOTHESIS: In type 1 diabetic patients with microalbuminuria not receiving antihypertensive treatment, an increase in urinary AER (UAER) of 6-14%/year and a risk of developing diabetic nephropathy (DN) of 3-30%/year have been reported. We audited the long-term effect of blocking the renin-a...

  11. Monitor voedselverspilling : mid-term rapportage

    NARCIS (Netherlands)

    Soethoudt, J.M.; Timmermans, A.J.M.

    2013-01-01

    Dit document is een mid-term rapportage, waarin de hoeveelheid voedselverspilling in 2009 en 2011 in kaart is gebracht. De onderzoeksvraag luidt: Bouw een structuur (monitor) om de voedselverspilling in Nederland in kaart te brengen en becijfer de voedselverspilling (zoveel mogelijk op basis van ope

  12. Supreme Court's New Term. Supreme Court Roundup.

    Science.gov (United States)

    Williams, Charles F.

    2002-01-01

    Discusses the issues addressed in the 2002 U.S. Supreme Court term, such as the First, Fourth, Eighth, and Fourteenth Amendments, cruel and unusual punishment, sex offender registries, fair housing, cross burning, jury selection, affirmative action, abortion protests, and copyrights and the public domain. (CMK)

  13. Visual Short-Term Memory Complexity

    DEFF Research Database (Denmark)

    Sørensen, Thomas Alrik

    Several recent studies have explored the nature and limits of visual short-term memory (VSTM) (e.g. Luck & Vogel, 1997). A general VSTM capacity limit of about 3 to 4 letters has been found, thus confirming results from earlier studies (e.g. Cattell, 1885; Sperling, 1960). However, Alvarez...

  14. Term Structure Analysis with Big Data

    DEFF Research Database (Denmark)

    Andreasen, Martin Møller; Christensen, Jens H.E.; Rudebusch, Glenn D.

    Analysis of the term structure of interest rates almost always takes a two-step approach. First, actual bond prices are summarized by interpolated synthetic zero-coupon yields, and second, a small set of these yields are used as the source data for further empirical examination. In contrast, we...

  15. Long Term Transfer Effect of Metaphoric Allusion.

    Science.gov (United States)

    Hayes, David A.; Mateja, John A.

    A study was conducted to investigate the long term transfer effect of metaphoric allusion used to clarify unfamiliar subject matter. Forty-nine high school students were given unfamiliar prose materials variously augmented by metaphoric allusion. The subjects' immediate performance on a transfer task was compared to their performance on an…

  16. Quantum Electrodynamics with the Pauli Term

    CERN Document Server

    Sastry, R R

    1999-01-01

    The quantum field theory of extended objects is employed to address the hitherto nonrenormalizable Pauli interaction. This is achieved by quantizing the Dirac field using the infinite dimensional generalization of the extended object formulation. The order $\\alpha$ contribution to the anomalous magnetic moment of the electron (and of the muon) arising from the Pauli term is calculated.

  17. Homocysteinemia After Hypertensive Pregnancy Disorders at Term

    NARCIS (Netherlands)

    Visser, Sanne; Hermes, Wietske; Blom, Henk J.; Heijboer, Annemieke C.; Franx, Arie; Van Pampus, Maria G.; Bloemenkamp, Kitty W. M.; Koopmans, Corine; Mol, Ben Willem J.; De Groot, Christianne J. M.

    2015-01-01

    Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascul

  18. Homocysteinemia after hypertensive pregnancy disorders at term

    NARCIS (Netherlands)

    Visser, Sanne; Hermes, Wietske; Blom, Henk J.; Heijboer, Annemieke C.; Franx, Arie; Van Pampus, Maria G.; Bloemenkamp, Kitty W M; Koopmans, Corine; Mol, Ben Willem J; De Groot, Christianne J M

    2015-01-01

    Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascul

  19. A gravity term from spontaneous symmetry breaking

    CERN Document Server

    Moise, Mihai

    2014-01-01

    In this model, the gravity term in the Lagrangean comes from spontaneous symmetry breaking of an additional scalar quadruplet field $\\Upsilon$. The resulting gravitational field is approximate to one of the models of coframe gravity with parameters $\\rho_1 + 4 \\rho_2 = 0$, $\\rho_3 = 0$. This article includes an exact solution of coframe gravity with model parameters $\\rho_1 \

  20. Coming to terms with English in Denmark

    DEFF Research Database (Denmark)

    Thøgersen, Jacob Martin

    2010-01-01

    to terms with that. Most striking is the great uniformity in the discourses through which English is constructed on the one hand as the default language of the world, on the other as a sign of modernity. An important by-product of the investigation is that it reveals how attitudes are constructed in situ...