Cell-specific prediction and application of drug-induced gene expression profiles.

Science.gov (United States)

Hodos, Rachel; Zhang, Ping; Lee, Hao-Chih; Duan, Qiaonan; Wang, Zichen; Clark, Neil R; Ma'ayan, Avi; Wang, Fei; Kidd, Brian; Hu, Jianying; Sontag, David; Dudley, Joel

2018-01-01

Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. However, limited data availability across cell types has hindered our capacity to leverage or explore the cell-specificity of these perturbations. While recent efforts have generated a large number of drug perturbation profiles across a variety of human cell types, many gaps remain in this combinatorial drug-cell space. Hence, we asked whether it is possible to fill these gaps by predicting cell-specific drug perturbation profiles using available expression data from related conditions--i.e. from other drugs and cell types. We developed a computational framework that first arranges existing profiles into a three-dimensional array (or tensor) indexed by drugs, genes, and cell types, and then uses either local (nearest-neighbors) or global (tensor completion) information to predict unmeasured profiles. We evaluate prediction accuracy using a variety of metrics, and find that the two methods have complementary performance, each superior in different regions in the drug-cell space. Predictions achieve correlations of 0.68 with true values, and maintain accurate differentially expressed genes (AUC 0.81). Finally, we demonstrate that the predicted profiles add value for making downstream associations with drug targets and therapeutic classes.

Advances in marine ice profiling for oil and gas applications

International Nuclear Information System (INIS)

Fissel, D.; Marko, J.; Melling, H.

2008-01-01

Developments in acoustic profiling technologies have allowed ever more accurate and information-rich extraction of data on the draft, undersurface topography and immediately adjacent water column environment of polar and other marine and freshwater ice covers. The purpose of these advances was to replace and improve upon other, often inconvenient, costly and/or otherwise unsatisfactory methodologies such as the use of upward looking sonar (ULS) sounders on submarines as well as deployments of airborne- sensors such as laser profilometers and electromagnetic induction instrumentation. ULS is a primary source of data for measurements of ice thickness. Self-contained units now have the data capacity and accuracy/resolution sufficient for unattended operation. Recent technological advances have now led to the next generation of ice profiling sonar (IPS), incorporating much expanded on-board data storage capacity and powerful onboard real-time firmware. This paper outlined the nature of the issues addressed in past oil and gas related ice profiling studies. The paper focused on identifying the key items of interest and the remaining uncertainties in the derived products. All of the data gathered in this regard was obtained with first generation profiling instrumentation of the type initially introduced by Melling and coworkers in 1995. The additional features of a recently introduced next generation IPS instrument were briefly described. The observed and potential benefits offered in oil and gas related applications were also presented. It was concluded that the next generation ice profilers sets the stage for research and development into the measurement of new ice parameters, the combination of information from ice profilers and all-weather radar satellite systems, and the possibility of remote access to the ice profiler data from multi-year moorings located well within the main Arctic Ocean ice pack. 11 refs., 10 figs

Application Profile Matching Method for Employees Online Recruitment

Science.gov (United States)

Sunarti; Rangga, Rahmadian Y.; Marlim, Yulvia Nora

2017-12-01

Employees is one of the determinant factors of company’s success. Thus, reliable human resources are needed to support the survival of the company. This research takes case study at PT. Asuransi Bina Dana Arta, Tbk Pekanbaru Branch. Employee recruitment system at PT. Asuransi Bina Dana Arta, Tbk Pekanbaru Branch still uses manual system as seen in application letter files file so it needs long time to determine accepted and rejected the application. For that it needs to built a system or application that allows companies in determining employees who accepted or rejected easily. Pofile Matching Method is a process of competency assessment that is done by comparing the value of written, psychological and interview test between one applicationt with other. PT. Asuransi Bina Dana Arta, Tbk Pekanbaru branch set the percentage to calculate NCF (Core Factor Value) by 60% and NSF (Secondary Factor Value) by 40%, and set the percentage to calculate the total value of written test by 40%, the total value of psycho test by 30%, and the total value of interview 30%. The final result of this study is to determine the rank or ranking of each applicant based on the greater value which, the greater that score of final result of an application get, the greater the chance of the applicant occupy a position or vacancy. Online Recruitment application uses profile matching method can help employee selection process and employee acceptance decisions quickly. This system can be viewed by directors or owners anywhere because it is online and used for other company branch

PhyDesign: an online application for profiling phylogenetic informativeness

Directory of Open Access Journals (Sweden)

Townsend Jeffrey P

2011-05-01

Full Text Available Abstract Background The rapid increase in number of sequenced genomes for species across of the tree of life is revealing a diverse suite of orthologous genes that could potentially be employed to inform molecular phylogenetic studies that encompass broader taxonomic sampling. Optimal usage of this diversity of loci requires user-friendly tools to facilitate widespread cost-effective locus prioritization for phylogenetic sampling. The Townsend (2007 phylogenetic informativeness provides a unique empirical metric for guiding marker selection. However, no software or automated methodology to evaluate sequence alignments and estimate the phylogenetic informativeness metric has been available. Results Here, we present PhyDesign, a platform-independent online application that implements the Townsend (2007 phylogenetic informativeness analysis, providing a quantitative prediction of the utility of loci to solve specific phylogenetic questions. An easy-to-use interface facilitates uploading of alignments and ultrametric trees to calculate and depict profiles of informativeness over specified time ranges, and provides rankings of locus prioritization for epochs of interest. Conclusions By providing these profiles, PhyDesign facilitates locus prioritization increasing the efficiency of sequencing for phylogenetic purposes compared to traditional studies with more laborious and low capacity screening methods, as well as increasing the accuracy of phylogenetic studies. Together with a manual and sample files, the application is freely accessible at http://phydesign.townsend.yale.edu.

In situ applications of a new diver-operated motorized microsensor profiler.

Science.gov (United States)

Weber, Miriam; Faerber, Paul; Meyer, Volker; Lott, Christian; Eickert, Gabriele; Fabricius, Katharina E; De Beer, Dirk

2007-09-01

Microsensors are powerful tools for microenvironment studies, however their use has often been restricted to laboratory applications due to the lack of adequate equipment for in situ deployments. Here we report on new features, construction details, and examples of applications of an improved diver-operated motorized microsensor profiler for underwater field operation to a water depth of 25 m. The new motorized profiler has a final precision of 5 microm, and can accommodate amperometric Clark-type microsensors for oxygen and hydrogen sulfide, potentiometric microsensors (e.g., for pH, Ca2+), and fiber-optic irradiance microsensors. The profiler is interfaced by a logger with a signal display, and has pushbuttons for underwater operation. The system can be pre-programmed to autonomous operation or interactively operated by divers. Internal batteries supply power for up to 24 h of measurements and 36 h of data storage (max. 64 million data points). Two flexible stands were developed for deployment on uneven or fragile surfaces, such as coral reefs. Three experimental pilot studies are presented, where (1) the oxygen distribution in a sand ripple was 3-D-mapped, (2) the microenvironment of sediment accumulated on a stony coral was studied, and (3) oxygen dynamics during an experimental sedimentation were investigated. This system allows SCUBA divers to perform a wide array of in situ measurements, with deployment precision and duration similar to those possible in the laboratory.

Development of feature extraction analysis for a multi-functional optical profiling device applied to field engineering applications

Science.gov (United States)

Han, Xu; Xie, Guangping; Laflen, Brandon; Jia, Ming; Song, Guiju; Harding, Kevin G.

2015-05-01

In the real application environment of field engineering, a large variety of metrology tools are required by the technician to inspect part profile features. However, some of these tools are burdensome and only address a sole application or measurement. In other cases, standard tools lack the capability of accessing irregular profile features. Customers of field engineering want the next generation metrology devices to have the ability to replace the many current tools with one single device. This paper will describe a method based on the ring optical gage concept to the measurement of numerous kinds of profile features useful for the field technician. The ring optical system is composed of a collimated laser, a conical mirror and a CCD camera. To be useful for a wide range of applications, the ring optical system requires profile feature extraction algorithms and data manipulation directed toward real world applications in field operation. The paper will discuss such practical applications as measuring the non-ideal round hole with both off-centered and oblique axes. The algorithms needed to analyze other features such as measuring the width of gaps, radius of transition fillets, fall of step surfaces, and surface parallelism will also be discussed in this paper. With the assistance of image processing and geometric algorithms, these features can be extracted with a reasonable performance. Tailoring the feature extraction analysis to this specific gage offers the potential for a wider application base beyond simple inner diameter measurements. The paper will present experimental results that are compared with standard gages to prove the performance and feasibility of the analysis in real world field engineering. Potential accuracy improvement methods, a new dual ring design and future work will be discussed at the end of this paper.

A Ravenscar-Java profile implementation

DEFF Research Database (Denmark)

Thomsen, Bent; Ravn, Anders Peter; Søndergaard, Hans

2006-01-01

This paper presents an implementation of the Ravenscar-Java profile. While most implementations of the profile are reference-implementations showing that it is possible to implement the profile, our implementation is aimed at industrial applications. It uses a dedicated real-time Java processor......, since we want to investigate if the Ravenscar-Java profile, implemented on a Java processor, is efficient for real applications. During the implementation some ambiguities and weaknesses of the profile were uncovered. However, test examples indicate that the profile is suitable for development...... of realistic real-time programs....

Direct method of deconvolution. Application to the interpretation of X ray diffraction line profiles

International Nuclear Information System (INIS)

Louer, Daniel

1969-01-01

In the first parts of this research thesis, the author reports the development of an original method of correction of X ray profiles, and the comparison of the different correction schemes within the frame of the analysis of a specific aberration of the diffractometer: the receiver slot. Based on corrected profiles, the author applied the different methods leading to the calculation of the dimensions and shape of particles which form a hydroxide nickel powder. He reports the physical-chemical analysis of nickel and zinc basic nitrates. Although some basic salts lead to widened X diffraction profiles the interpretation of which remains to be made, this work remained limited to the application of the described methods to the nickel hydroxide sample resulting from an extended hydrolysis of nickel basic nitrates

Uses of Youth Risk Behavior Survey and School Health Profiles Data: Applications for Improving Adolescent and School Health

Science.gov (United States)

Foti, Kathryn; Balaji, Alexandra; Shanklin, Shari

2011-01-01

Background: To monitor priority health risk behaviors and school health policies and practices, respectively, the Centers for Disease Control and Prevention (CDC) developed the Youth Risk Behavior Surveillance System (YRBSS) and the School Health Profiles (Profiles). CDC is often asked about the use and application of these survey data to improve…

Recent RF Experiments and Application of RF Waves to Real-Time Control of Safety Factor Profile in JT-60U

International Nuclear Information System (INIS)

Suzuki, T.; Isayama, A.; Ide, S.; Fujita, T.; Oikawa, T.; Sakata, S.; Sueoka, M.; Hosoyama, H.; Seki, M.

2005-01-01

Two topics of applications of RF waves to current profile control in JT-60U are presented; application of lower-hybrid (LH) waves to safety factor profile control and electron cyclotron (EC) waves to neo-classical tearing mode (NTM) control. A real-time control system of safety factor (q) profile was developed. This system, for the first time, enables 1) real time evaluation of q profile using local magnetic pitch angle measurement by motional Stark effect (MSE) diagnostic and 2) control of current drive (CD) location (ρCD) by controlling the parallel refractive index N parallel of LH waves through control of phase difference (Δφ) of LH waves between multi-junction launcher modules. The method for real-time q profile evaluation was newly developed, without time-consuming reconstruction of equilibrium, so that the method requires less computational time. Safety factor profile by the real-time calculation agrees well with that by equilibrium reconstruction with MSE. The control system controls ρCD through Δφ in such a way to decrease the largest residual between the real-time evaluated q profile q(r) and its reference profile qref(r). The real-time control system was applied to a positive shear plasma (q(0)∼1). The reference q profile was set to monotonic positive shear profile having qref(0)=1.3. The real-time q profile approached to the qref(r) during application of real-time control, and was sustained for 3s, which was limited by the duration of the injected LH power. Temporal evolution of current profile was consistent with relaxation of inductive electric field induced by theoretical LH driven current. An m/n=3/2 NTM that appeared at βN∼3 was completely stabilized by ECCD applied to a fully-developed NTM. Precise ECCD at NTM island was essential for the stabilization. ECCD that was applied to resonant rational surface (q=3/2) before an NTM onset suppressed appearance of NTM. In order to keep NTM intensity below a level, ECCD before the mode onset was

Real field mission profile oriented design of a SiC-based PV-inverter application

DEFF Research Database (Denmark)

Sintamarean, Nicolae Christian; Blaabjerg, Frede; Wang, Huai

2013-01-01

This paper introduces a real field mission profile oriented design tool for the new generation of grid connected PV-inverters applications based on SiC-devices. The proposed design tool consists of a grid connected PV-inverter model, an ElectroThermal model, a converter safe operating area (SOA...... Zth_H in order to perform in a safe mode for the whole operating range. Furthermore, the proposed design tool considers the mission profile (the measured solar irradiance and ambient temperature) from the real field where the converter will operate. Thus, a realistic loading of the converter devices......) model, a mission profile model and an the evaluation block. The PV-system model involves a three level bipolar switch neutral point clamped (3L-BS NPC) inverter connected to the three phase grid through a LCL-filter. Moreover, the SOA model calculates the required converter heatsink thermal impedance...

Generalized pixel profiling and comparative segmentation with application to arteriovenous malformation segmentation.

Science.gov (United States)

Babin, D; Pižurica, A; Bellens, R; De Bock, J; Shang, Y; Goossens, B; Vansteenkiste, E; Philips, W

2012-07-01

Extraction of structural and geometric information from 3-D images of blood vessels is a well known and widely addressed segmentation problem. The segmentation of cerebral blood vessels is of great importance in diagnostic and clinical applications, with a special application in diagnostics and surgery on arteriovenous malformations (AVM). However, the techniques addressing the problem of the AVM inner structure segmentation are rare. In this work we present a novel method of pixel profiling with the application to segmentation of the 3-D angiography AVM images. Our algorithm stands out in situations with low resolution images and high variability of pixel intensity. Another advantage of our method is that the parameters are set automatically, which yields little manual user intervention. The results on phantoms and real data demonstrate its effectiveness and potentials for fine delineation of AVM structure. Copyright © 2012 Elsevier B.V. All rights reserved.

High-resolution humidity profiles retrieved from wind profiler radar measurements

Science.gov (United States)

Saïd, Frédérique; Campistron, Bernard; Di Girolamo, Paolo

2018-03-01

The retrieval of humidity profiles from wind profiler radars has already been documented in the past 30 years and is known to be neither as straightforward and nor as robust as the retrieval of the wind velocity. The main constraint to retrieve the humidity profile is the necessity to combine measurements from the wind profiler and additional measurements (such as observations from radiosoundings at a coarser time resolution). Furthermore, the method relies on some assumptions and simplifications that restrict the scope of its application. The first objective of this paper is to identify the obstacles and limitations and solve them, or at least define the field of applicability. To improve the method, we propose using the radar capacity to detect transition levels, such as the top level of the boundary layer, marked by a maximum in the radar reflectivity. This forces the humidity profile from the free troposphere and from the boundary layer to coincide at this level, after an optimization of the calibration coefficients, and reduces the error. The resulting mean bias affecting the specific humidity profile never exceeds 0.25 g kg-1. The second objective is to explore the capability of the algorithm to retrieve the humidity vertical profiles for an operational purpose by comparing the results with observations from a Raman lidar.

Molecular genotyping of Echinococcus granulosus using formalin-fixed paraffin-embedded preparations from human isolates in unusual tissue sites.

Science.gov (United States)

Hizem, A; M'rad, S; Oudni-M'rad, M; Mestiri, S; Hammedi, F; Mezhoud, H; Zakhama, A; Mokni, M; Babba, H

2016-07-01

Cystic echinococcosis (CE) caused by Echinococcus granulosus remains a serious problem worldwide for issues relating to public health and the economy. The most predominantly affected sites are the liver and the lungs, but other organs such as the heart, the spleen and the peritoneum can also be infected. Access to cysts from uncommon sites has limited genomic and molecular investigations. In the present study, genotypes of E. granulosus sensu lato were identified from formalin-fixed paraffin-embedded tissues (FF-PETs) implicated in human CE. Tissue samples were obtained from 57 patients with histologically confirmed CE. DNA samples were analysed using Egss 1 polymerase chain reaction (PCR) specific to the mitochondrial 12S rRNA gene of E. granulosus sensu stricto. All cysts were typed as E. granulosus sensu stricto with up to 35% of the liver and 16.6% of lungs being the most frequently infected, and up to 48.4% of samples being from rare sites. No correlation was found between cyst site and either the gender or the age of patients. This study demonstrates the possibility of exploiting atypical cysts using FF-PET samples and highlights the predominance of E. granulosus sensu stricto species in the Tunisian population, even in unusual infection sites.

Application of constrained deconvolution technique for reconstruction of electron bunch profile with strongly non-Gaussian shape

Science.gov (United States)

Geloni, G.; Saldin, E. L.; Schneidmiller, E. A.; Yurkov, M. V.

2004-08-01

An effective and practical technique based on the detection of the coherent synchrotron radiation (CSR) spectrum can be used to characterize the profile function of ultra-short bunches. The CSR spectrum measurement has an important limitation: no spectral phase information is available, and the complete profile function cannot be obtained in general. In this paper we propose to use constrained deconvolution method for bunch profile reconstruction based on a priori-known information about formation of the electron bunch. Application of the method is illustrated with practically important example of a bunch formed in a single bunch-compressor. Downstream of the bunch compressor the bunch charge distribution is strongly non-Gaussian with a narrow leading peak and a long tail. The longitudinal bunch distribution is derived by measuring the bunch tail constant with a streak camera and by using a priory available information about profile function.

Application of constrained deconvolution technique for reconstruction of electron bunch profile with strongly non-Gaussian shape

International Nuclear Information System (INIS)

Geloni, G.; Saldin, E.L.; Schneidmiller, E.A.; Yurkov, M.V.

2004-01-01

An effective and practical technique based on the detection of the coherent synchrotron radiation (CSR) spectrum can be used to characterize the profile function of ultra-short bunches. The CSR spectrum measurement has an important limitation: no spectral phase information is available, and the complete profile function cannot be obtained in general. In this paper we propose to use constrained deconvolution method for bunch profile reconstruction based on a priori-known information about formation of the electron bunch. Application of the method is illustrated with practically important example of a bunch formed in a single bunch-compressor. Downstream of the bunch compressor the bunch charge distribution is strongly non-Gaussian with a narrow leading peak and a long tail. The longitudinal bunch distribution is derived by measuring the bunch tail constant with a streak camera and by using a priory available information about profile function

Application of Fourier analysis to the study of roughness profiles of eroded samples

International Nuclear Information System (INIS)

Bethencourt, M.; Botana, F.J.; Calvino, J.J.; Marcos, M.; Rodriguez-Chacon, M.A.

1998-01-01

Fourier transforms are applied to analyse surface roughness profiles recorded on samples coming from erosion-corrosion essays. The information retrieved using this method clearly complements that revealed by the more classical roughness amplitude parameters. The analysis procedure here proposed can be applied not only to characterise the surface of corroded samples but, in general, to evaluate the quality of any surface after application of finishing treatments. (Author) 7 refs

Identifying seasonal mobility profiles from anonymized and aggregated mobile phone data. Application in food security.

Science.gov (United States)

Zufiria, Pedro J; Pastor-Escuredo, David; Úbeda-Medina, Luis; Hernandez-Medina, Miguel A; Barriales-Valbuena, Iker; Morales, Alfredo J; Jacques, Damien C; Nkwambi, Wilfred; Diop, M Bamba; Quinn, John; Hidalgo-Sanchís, Paula; Luengo-Oroz, Miguel

2018-01-01

We propose a framework for the systematic analysis of mobile phone data to identify relevant mobility profiles in a population. The proposed framework allows finding distinct human mobility profiles based on the digital trace of mobile phone users characterized by a Matrix of Individual Trajectories (IT-Matrix). This matrix gathers a consistent and regularized description of individual trajectories that enables multi-scale representations along time and space, which can be used to extract aggregated indicators such as a dynamic multi-scale population count. Unsupervised clustering of individual trajectories generates mobility profiles (clusters of similar individual trajectories) which characterize relevant group behaviors preserving optimal aggregation levels for detailed and privacy-secured mobility characterization. The application of the proposed framework is illustrated by analyzing fully anonymized data on human mobility from mobile phones in Senegal at the arrondissement level over a calendar year. The analysis of monthly mobility patterns at the livelihood zone resolution resulted in the discovery and characterization of seasonal mobility profiles related with economic activities, agricultural calendars and rainfalls. The use of these mobility profiles could support the timely identification of mobility changes in vulnerable populations in response to external shocks (such as natural disasters, civil conflicts or sudden increases of food prices) to monitor food security.

Identifying seasonal mobility profiles from anonymized and aggregated mobile phone data. Application in food security.

Directory of Open Access Journals (Sweden)

Pedro J Zufiria

Full Text Available We propose a framework for the systematic analysis of mobile phone data to identify relevant mobility profiles in a population. The proposed framework allows finding distinct human mobility profiles based on the digital trace of mobile phone users characterized by a Matrix of Individual Trajectories (IT-Matrix. This matrix gathers a consistent and regularized description of individual trajectories that enables multi-scale representations along time and space, which can be used to extract aggregated indicators such as a dynamic multi-scale population count. Unsupervised clustering of individual trajectories generates mobility profiles (clusters of similar individual trajectories which characterize relevant group behaviors preserving optimal aggregation levels for detailed and privacy-secured mobility characterization. The application of the proposed framework is illustrated by analyzing fully anonymized data on human mobility from mobile phones in Senegal at the arrondissement level over a calendar year. The analysis of monthly mobility patterns at the livelihood zone resolution resulted in the discovery and characterization of seasonal mobility profiles related with economic activities, agricultural calendars and rainfalls. The use of these mobility profiles could support the timely identification of mobility changes in vulnerable populations in response to external shocks (such as natural disasters, civil conflicts or sudden increases of food prices to monitor food security.

Android Based Binus Profile Applications as the Marketing Tools of Bina Nusantara University

Science.gov (United States)

Iskandar, Karto

2014-03-01

Smart phones with apps in it is not a new phenomenon. Both of technologies have been fused with the lifestyle today. The ease and speed of access to information makes a lot of companies use it in the process of marketing a product to the public. Objective of this action is to win the competition that more competitive. The purpose of this research is to create mobile application android based to assist in the marketing and introduction Bina Nusantara University profile to prospective students. This research method using software engineering waterfall model to produce Android-based mobile applications. The results in the form of Android-based mobile application that can be used as a viral marketing tool for Bina Nusantara University. At the end of this study can be generated that mobile technology can be used as a media for effective marketing and branding, especially for Bina Nusantara University. Android technology based for marketing applications suited to the Bina Nusantara University applicant segment which are generally young people. The future along with the improvement of network quality and affordable cost, then the application can be made online, so features such as chat, maps, and other can be used optimally.

Control sample design using a geodemographic discriminator: An application of Super Profiles

Science.gov (United States)

Brown, Peter J. B.; McCulloch, Peter G.; Williams, Evelyn M. I.; Ashurst, Darren C.

The development and application of an innovative sampling framework for use in a British study of the early detection of gastric cancer are described. The Super Profiles geodemographic discriminator is used in the identification of geographically distinct control and contrast areas from which samples of cancer registry case records may be drawn for comparison with the records of patients participating in the gastric cancer intervention project. Preliminary results of the application of the framework are presented and confirm its effectiveness in satisfactorily reflecting known patterns of variation in cancer occurrence by age, gender and social class. The method works well for cancers with a known and clear social gradient, such as lung and breast cancer, moderately well for gastric cancer and somewhat less well for oesophageal cancer, where the social class gradient is less clear.

Android Based Binus Profile Applications as the Marketing Tools of Bina Nusantara University

Directory of Open Access Journals (Sweden)

Iskandar Karto

2014-03-01

Full Text Available Smart phones with apps in it is not a new phenomenon. Both of technologies have been fused with the lifestyle today. The ease and speed of access to information makes a lot of companies use it in the process of marketing a product to the public. Objective of this action is to win the competition that more competitive. The purpose of this research is to create mobile application android based to assist in the marketing and introduction Bina Nusantara University profile to prospective students. This research method using software engineering waterfall model to produce Android-based mobile applications. The results in the form of Android-based mobile application that can be used as a viral marketing tool for Bina Nusantara University. At the end of this study can be generated that mobile technology can be used as a media for effective marketing and branding, especially for Bina Nusantara University. Android technology based for marketing applications suited to the Bina Nusantara University applicant segment which are generally young people. The future along with the improvement of network quality and affordable cost, then the application can be made online, so features such as chat, maps, and other can be used optimally.

Elementary Analysis of Petroleum Distillates by Gc-Aed: Validation and Application to the Calculation of Distillation Profile Properties

Directory of Open Access Journals (Sweden)

Baco F.

1999-07-01

Full Text Available This article describes the development of elementary analysis in the distillation profile of petroleum cuts by gas phase chromatography-atomic emission detection (GC-AED coupling and shows the application perspectives to characterisation of middle distillates of a piece of information unheard of until now on a routine basis. The performances of the analytical assembly used have been studied for carbon, hydrogen, sulphur and nitrogen analysis. Simulated distillation, a gas phase chromatography analysis which enables determining the weight percentage of distilled matter in relation to the boiling point of petroleum cuts, has been adapted to GC-AED coupling. We have developed a method giving access to three types of information: global elementary composition, simulated distillation and elementary composition in distillation profile, i. e. by fraction (% of the distilled product. The analysis of the atmospheric distillates has been assessed in terms of precision and bias for these various types of information. The validation was carried out notably by comparison with the results obtained using reference analytical methods, on preparative distillation cuts of representative samples. The application of GC-AED to characterisation of distillates is discussed, in particular for classification purposes and for predicting petroleum properties in the distillation profile. The cetane number of gas oils was taken as an example to illustrate the latter application.

Applications of Bayesian temperature profile reconstruction to automated comparison with heat transport models and uncertainty quantification of current diffusion

International Nuclear Information System (INIS)

Irishkin, M.; Imbeaux, F.; Aniel, T.; Artaud, J.F.

2015-01-01

Highlights: • We developed a method for automated comparison of experimental data with models. • A unique platform implements Bayesian analysis and integrated modelling tools. • The method is tokamak-generic and is applied to Tore Supra and JET pulses. • Validation of a heat transport model is carried out. • We quantified the uncertainties due to Te profiles in current diffusion simulations. - Abstract: In the context of present and future long pulse tokamak experiments yielding a growing size of measured data per pulse, automating data consistency analysis and comparisons of measurements with models is a critical matter. To address these issues, the present work describes an expert system that carries out in an integrated and fully automated way (i) a reconstruction of plasma profiles from the measurements, using Bayesian analysis (ii) a prediction of the reconstructed quantities, according to some models and (iii) a comparison of the first two steps. The first application shown is devoted to the development of an automated comparison method between the experimental plasma profiles reconstructed using Bayesian methods and time dependent solutions of the transport equations. The method was applied to model validation of a simple heat transport model with three radial shape options. It has been tested on a database of 21 Tore Supra and 14 JET shots. The second application aims at quantifying uncertainties due to the electron temperature profile in current diffusion simulations. A systematic reconstruction of the Ne, Te, Ti profiles was first carried out for all time slices of the pulse. The Bayesian 95% highest probability intervals on the Te profile reconstruction were then used for (i) data consistency check of the flux consumption and (ii) defining a confidence interval for the current profile simulation. The method has been applied to one Tore Supra pulse and one JET pulse.

Applications of positron depth profiling

Energy Technology Data Exchange (ETDEWEB)

Hakvoort, R A

1993-12-23

In this thesis some contributions of the positron-depth profiling technique to materials science have been described. Following studies are carried out: Positron-annihilation measurements on neon-implanted steel; Void creation in silicon by helium implantation; Density of vacancy-type defects present in amorphous silicon prepared by ion implantation; Measurements of other types of amorphous silicon; Epitaxial cobalt disilicide prepared by cobalt outdiffusion. Positron-annihilation experiments on low-pressure CVD silicon-nitride films. (orig./MM).

Applications of positron depth profiling

International Nuclear Information System (INIS)

Hakvoort, R.A.

1993-01-01

In this thesis some contributions of the positron-depth profiling technique to materials science have been described. Following studies are carried out: Positron-annihilation measurements on neon-implanted steel; Void creation in silicon by helium implantation; Density of vacancy-type defects present in amorphous silicon prepared by ion implantation; Measurements of other types of amorphous silicon; Epitaxial cobalt disilicide prepared by cobalt outdiffusion. Positron-annihilation experiments on low-pressure CVD silicon-nitride films. (orig./MM)

A Profile for Safety Critical Java

DEFF Research Database (Denmark)

Schoeberl, Martin; Søndergaard, Hans; Thomsen, Bent

2007-01-01

We propose a new, minimal specification for real-time Java for safety critical applications. The intention is to provide a profile that supports programming of applications that can be validated against safety critical standards such as DO-178B [15]. The proposed profile is in line with the Java...... specification request JSR-302: Safety Critical Java Technology, which is still under discussion. In contrast to the current direction of the expert group for the JSR-302 we do not subset the rather complex Real-Time Specification for Java (RTSJ). Nevertheless, our profile can be implemented on top of an RTSJ...

Vertical grid of retrieved atmospheric profiles

International Nuclear Information System (INIS)

Ceccherini, Simone; Carli, Bruno; Raspollini, Piera

2016-01-01

The choice of the vertical grid of atmospheric profiles retrieved from remote sensing observations is discussed considering the two cases of profiles used to represent the results of individual measurements and of profiles used for subsequent data fusion applications. An ozone measurement of the MIPAS instrument is used to assess, for different vertical grids, the quality of the retrieved profiles in terms of profile values, retrieval errors, vertical resolutions and number of degrees of freedom. In the case of individual retrievals no evident advantage is obtained with the use of a grid finer than the one with a reduced number of grid points, which are optimized according to the information content of the observations. Nevertheless, this instrument dependent vertical grid, which seems to extract all the available information, provides very poor results when used for data fusion applications. A loss of about a quarter of the degrees of freedom is observed when the data fusion is made using the instrument dependent vertical grid relative to the data fusion made using a vertical grid optimized for the data fusion product. This result is explained by the analysis of the eigenvalues of the Fisher information matrix and leads to the conclusion that different vertical grids must be adopted when data fusion is the expected application. - Highlights: • Data fusion application is taken into account for the choice of the vertical grid. • The study is performed using ozone profiles retrieved from MIPAS measurements. • A very fine vertical grid is not needed for the analysis of a single instrument. • The instrument dependent vertical grid is not the best choice for data fusion. • A data fusion dependent vertical grid must be used for profiles that will be fused.

Wind profiler mixing depth and entrainment measurements with chemical applications

Energy Technology Data Exchange (ETDEWEB)

Angevine, W.M.; Trainer, M.; Parrish, D.D.; Buhr, M.P.; Fehsenfeld, F.C. [NOAA Aeronomy Lab., Boulder, CO (United States); Kok, G.L. [NCAR Research Aviation Facility, Boulder, CO (United States)

1994-12-31

Wind profiling radars operating at 915 MHz have been present at a number of regional air quality studies. The profilers can provide a continuous, accurate record of the depth of the convective mixed layer with good time resolution. Profilers also provide information about entrainment at the boundary layer top. Mixing depth data from several days of the Rural Oxidants in the Southern Environment II (ROSE II) study in Alabama in June, 1992 are presented. For several cases, chemical measurements from aircraft and ground-based instruments are shown to correspond to mixing depth and entrainment zone behavior observed by the profiler.

Evolution of low-profile and lightweight electrical connectors for soldier-worn applications

Science.gov (United States)

Gans, Eric; Lee, Kang; Jannson, Tomasz; Walter, Kevin

2011-06-01

In addition to military radios, modern warfighters carry cell phones, GPS devices, computers, and night-vision aids, all of which require electrical cables and connectors for data and power transmission. Currently each electrical device operates via independent cables using conventional cable and connector technology. Conventional cables are stiff and difficult to integrate into a soldier-worn garment. Conventional connectors are tall and heavy, as they were designed to ensure secure connections to bulkhead-type panels, and being tall, represent significant snag-hazards in soldier-worn applications. Physical Optics Corporation has designed a new, lightweight and low-profile electrical connector that is more suitable for body-worn applications and operates much like a standard garment snap. When these connectors are mated, the combined height is <0.3 in. - a significant reduction from the 2.5 in. average height of conventional connectors. Electrical connections can be made with one hand (gloved or bare) and blindly (without looking). Furthermore, POC's connectors are integrated into systems that distribute data or power from a central location on the soldier's vest, reducing the length and weight of the cables necessary to interconnect various mission-critical electronic systems. The result is a lightweight power/data distribution system offering significant advantages over conventional electrical connectors in soldier-worn applications.

Application of MySQL in instantaneous profile gauge system

International Nuclear Information System (INIS)

Guo Xiaojing; Miao Jichen; Wu Zhifang

2011-01-01

As equipment in the hot rolling plate plant for online measurement of strip steel, the instantaneous profile gauge is used to measure instant crown of hot rolling strips and feed back the crown to the rolling mill to adjust strip profile. During the measurement, a large amount of data need to be stored reasonably for query, display, computation and other processing, while a database management software can make it happen. Based on such features of MySQL as small size, fast speed, low cost and open source codes, a database function was implemented in the instantaneous profile gauge for data storage, query and maintenance, by applying MySQL database management system and integrating with the control interface. (authors)

Further Examining Berry's Model: The Applicability of Latent Profile Analysis to Acculturation

Science.gov (United States)

Fox, Rina S.; Merz, Erin L.; Solórzano, Martha T.; Roesch, Scott C.

2013-01-01

This study used latent profile analysis (LPA) to identify acculturation profiles. A three-profile solution fit the data best, and comparisons on demographic and psychosocial outcomes as a function of profile yielded expected results. The findings support using LPA as a parsimonious way to model acculturation without anticipating profiles in…

The role of drug profiles as similarity metrics: applications to repurposing, adverse effects detection and drug-drug interactions.

Science.gov (United States)

Vilar, Santiago; Hripcsak, George

2017-07-01

Explosion of the availability of big data sources along with the development in computational methods provides a useful framework to study drugs' actions, such as interactions with pharmacological targets and off-targets. Databases related to protein interactions, adverse effects and genomic profiles are available to be used for the construction of computational models. In this article, we focus on the description of biological profiles for drugs that can be used as a system to compare similarity and create methods to predict and analyze drugs' actions. We highlight profiles constructed with different biological data, such as target-protein interactions, gene expression measurements, adverse effects and disease profiles. We focus on the discovery of new targets or pathways for drugs already in the pharmaceutical market, also called drug repurposing, in the interaction with off-targets responsible for adverse reactions and in drug-drug interaction analysis. The current and future applications, strengths and challenges facing all these methods are also discussed. Biological profiles or signatures are an important source of data generation to deeply analyze biological actions with important implications in drug-related studies. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Advantages of the in-situ LTP distortion profile test on high-heat-load mirrors and applications

International Nuclear Information System (INIS)

Qian, S.; Jark, W.; Sostero, G.; Gambitta, A.; Mazzolini, F.; Savoia, A.

1996-01-01

The first in-situ distortion profile measurement of a high heat load mirror by use of the penta-prism LTP is presented. A maximum height distortion of 0.47 micron in tangential direction over a length of 180 mm was measured for an internally water-cooled mirror of a undulator beam line at ELETTRA while exposed to a total emitted power of 600 W (undulator gap 30 mm and current 180 mA). The experiment has an accuracy and repeatability of 0.04 micron. The test schematic and the test equipment are presented. Two measuring methods to scan a penta-prism being installed either outside or inside the vacuum chamber are introduced. Advantages and some possible applications of adopting the penta-prism LTP to make the in-situ profile test are explained

UAV applications for thermodynamic profiling: Emphasis on ice fog research

Science.gov (United States)

Gultepe, Ismail; Heymsfield, Andrew J.; Fernando, Harindra J. S.; Hoch, Sebastian W.; Ware, Randolph

2016-04-01

Ice fog occurs often over the Arctic, cold climatic, and mountainous regions for about 30% of time where temperature (T) can go down to -10°C or below. Ice Nucleation (IN) and cooling processes play an important role by the controlling the intensity of ice fog conditions that affect aviation application, transportation, and local climate. Ice fog can also occur at T above -10°C but close to 0°C it occurs due to freezing of supercooled droplets that include an IN. To better document ice fog conditions, observations from the ice fog events of the Indirect and Semi-Direct Aerosol effects on Climate (ISDAC) project, Barrow, Alaska, Fog Remote Sensing And Modeling (FRAM) project Yellowknife, Northwest Territories, and the Mountain Terrain Atmospheric Modeling and Observations (MATERHORN) project, Heber City, Utah, were analyzed.. Measurements difficulties of small ice fog particles at cold temperatures and low-level flying restrictions prevent observations from aircraft within the surface boundary layer. However, unmanned Aerial Vehicles (UAVs) can be operated safely to measure IN number concentration, Relative Humidity with respect to ice (RHi), T, horizontal wind speed (Uh) and direction, and ice crystal spectra less than about 500 micron. Thermodynamic profiling by a Radiometrics Profiling Microwave Radiometer (PMWR) and Vaisala CL51 ceilometer was used to describe ice fog conditions in the vertical and its time development. In this presentation, ice fog characteristics and its thermodynamic environment will be presented using both ground-based and airborne platforms such as a UAV with new sensors. Some examples of measurements from the UAV for future research, and challenges related to both ice fog measurements and visibility parameterization will also be presented.

Assimilation of NUCAPS Retrieved Profiles in GSI for Unique Forecasting Applications

Science.gov (United States)

Berndt, Emily Beth; Zavodsky, Bradley; Srikishen, Jayanthi; Blankenship, Clay

2015-01-01

Hyperspectral IR profiles can be assimilated in GSI as a separate observation other than radiosondes with only changes to tables in the fix directory. Assimilation of profiles does produce changes to analysis fields and evidenced by: Innovations larger than +/-2.0 K are present and represent where individual profiles impact the final temperature analysis.The updated temperature analysis is colder behind the cold front and warmer in the warm sector. The updated moisture analysis is modified more in the low levels and tends to be drier than the original model background Analysis of model output shows: Differences relative to 13-km RAP analyses are smaller when profiles are assimilated with NUCAPS errors. CAPE is under-forecasted when assimilating NUCAPS profiles, which could be problematic for severe weather forecasting Refining the assimilation technique to incorporate an error covariance matrix and creating a separate GSI module to assimilate satellite profiles may improve results.

From the profile of position to the profile of competences in human talent management

Directory of Open Access Journals (Sweden)

Marianela Bermejo-Salmon

2017-12-01

Full Text Available The objective of this study was the application of a methodology for the making of a position profile by competences with a holistic approach from the position of school director or engineering career of enterprises of the Faculty of Enterprises Administration in the Higher Polytechnical School of Chimborazo of Ecuador. Theoretical and empirical methods were used such as: Dialectical and Historical Materialism as a method that allows to establish the didactic logic in treating processes, the Delphi method and the holistic and integrated approach and techniques used were: group work, direct observation, functional analysis, psychological tests and interviews. As result, the application of this methodology to integrate the position profile and profile of labor competences as a unique system and insert them to other contexts outside the Cuban frontier from its adequacy to the particularities that characterize the negotiation of the human talent in the selected place.

Active core profile and transport modification by application of Ion Bernstein Wave power in PBX-M

International Nuclear Information System (INIS)

LeBlanc, B.; Bell, R.

1995-01-01

Application of Ion Bernstein Wave Heating (IBWH) into the Princeton Beta Experiment-Modification (PBX-M) tokamak stabilizes sawtooth oscillations and generates peaked density profiles. A transport barrier, spatially correlated with the IBWH power deposition profile, is observed in the core of IBWH assisted neutral beam injection (NBI) discharges. A precursor to the fully developed barrier is seen in the soft x-ray data during edge localized mode (ELM) activity. Sustained IBWH operation is conducive to a regime where the barrier supports large triangledown n e , triangledown T e , triangledown v phi , and triangledown T i , delimiting the confinement zone. This regime is reminiscent of the H(high)-mode but with a confinement zone moved inwards. The core region has better than H-mode confinement while the peripheral region is L(low)-mode-like. The peaked profile enhanced NBI core deposition and increases nuclear reactivity. An increase in central T i results from χ i reduction (compared to H-mode) and better beam penetration. Bootstrap current fractions of up to 0.32--0.35 locally and 0.28 overall were obtained when an additional NBI burst is applied to this plasma

Low-profile natural and metamaterial antennas analysis methods and applications

CERN Document Server

Nakano, Hisamatsu

2017-01-01

This book presents the full range of low-profile antennas that use novel elements and take advantage of new concepts in antenna implementation, including metamaterials. Typically formed by constructing lattices of simple elements, metamaterials possess electromagnetic properties not found in naturally occurring materials, and show great promise in a number of low-profile antenna implementations. Introductory chapters define various natural and metamaterial-based antennas and provide the fundamentals of writing computer programs based on the method of moments (MoM) and the finite-difference time-domain method (FDTDM). Chapters then discuss low-profile natural antennas classified into base station antennas, mobile card antennas, beam-forming antennas, and satellite-satellite and earth-satellite communications antennas. Final chapters look at various properties of low-profile metamaterial-based ant nnas, revealing the strengths and limitations of the metamaterial-based straight line antenna (metaline antenna), m...

A Comparison Between Jerusalem Cross and Square Patch Frequency Selective Surfaces for Low Profile Antenna Applications

Science.gov (United States)

Cure, David; Weller, Thomas; Miranda, Felix A.

2011-01-01

In this paper, a comparison between Jerusalem Cross (JC) and Square Patch (SP) based Frequency Selected Surfaces (FSS) for low profile antenna applications is presented. The comparison is aimed at understanding the performance of low profile antennas backed by high impedance surfaces. In particular, an end loaded planar open sleeve dipole (ELPOSD) antenna is examined due to the various parameters within its configuration, offering significant design flexibility and a wide operating bandwidth. Measured data of the antennas demonstrate that increasing the number of unit cells improves the fractional bandwidth. The antenna bandwidth increased from 0.8% to 1.8% and from 0.8% to 2.7% for the JC and SP structures, respectively. The number of unit cells was increased from 48 to 80 for the JC-FSS and from 24 to 48 for the SP-FSS.

Chemical water shutoff profile research status and development trends

Science.gov (United States)

Xu, L. T.

2017-08-01

Excess water production is now a common problem encountered in almost every water flooding mature oilfield. The exploitation of oil field is faced with great challenge because of the decrease of oil field production. For the development of high water cut rare the status quo chemical water shutoff profile control technology is an important solution to solve this problem. Oilfield chemical water shutoff has important application prospects. This paper analyzes the water shutoff profile control and water shutoff profile control agent currently oilfield applications, moreover the use and development of blocking agent profile technology is to improve reservoir recovery and propose solutions. With the constant increase in water cut, profile technology should be simple, efficient, practical and profile control agent of development should be economic, environmental, and long period

New dynamic NNORSY ozone profile climatology

Science.gov (United States)

Kaifel, A. K.; Felder, M.; Declercq, C.; Lambert, J.-C.

2012-01-01

Climatological ozone profile data are widely used as a-priori information for total ozone using DOAS type retrievals as well as for ozone profile retrieval using optimal estimation, for data assimilation or evaluation of 3-D chemistry-transport models and a lot of other applications in atmospheric sciences and remote sensing. For most applications it is important that the climatology represents not only long term mean values but also the links between ozone and dynamic input parameters. These dynamic input parameters should be easily accessible from auxiliary datasets or easily measureable, and obviously should have a high correlation with ozone. For ozone profile these parameters are mainly total ozone column and temperature profile data. This was the outcome of a user consultation carried out in the framework of developing a new, dynamic ozone profile climatology. The new ozone profile climatology is based on the Neural Network Ozone Retrieval System (NNORSY) widely used for ozone profile retrieval from UV and IR satellite sounder data. NNORSY allows implicit modelling of any non-linear correspondence between input parameters (predictors) and ozone profile target vector. This paper presents the approach, setup and validation of a new family of ozone profile climatologies with static as well as dynamic input parameters (total ozone and temperature profile). The neural network training relies on ozone profile measurement data of well known quality provided by ground based (ozonesondes) and satellite based (SAGE II, HALOE, and POAM-III) measurements over the years 1995-2007. In total, four different combinations (modes) for input parameters (date, geolocation, total ozone column and temperature profile) are available. The geophysical validation spans from pole to pole using independent ozonesonde, lidar and satellite data (ACE-FTS, AURA-MLS) for individual and time series comparisons as well as for analysing the vertical and meridian structure of different modes of

Application of high-resolution domestic electricity load profiles in network modelling

DEFF Research Database (Denmark)

Marszal, Anna Joanna; Mendaza, Iker Diaz de Cerio; Heiselberg, Per Kvols

2016-01-01

the generated profiles are inputted in a low-voltage network model created in DIgSILENT PowerFactory. By means of employing 1 hour based demand and generation profiles in during dynamic studies, the representation of the local power system performance might sometimes not be as accurate as needed. In the test...... with modeling when 1-minute domestic electricity demand and generation profiles are used as inputs. The analysis is done with a case study of low-voltage network located in Northern Denmark. The analysis includes two parts. The first part focuses on modeling the domestic demands and on-site generation in 1......-minute resolution. The load profiles of the household appliances are created using a bottom-up model, which uses the 1-minute cycle power use characteristics of a single appliance as the main building block. The profiles of heavy electric appliances, such as heat pump, are not included in the above...

Scaling laws for TEXT plasma profiles

International Nuclear Information System (INIS)

McCool, S.C.; Bravenec, R.V.; Chen, J.Y.; Foster, M.S.; Li, W.L.; Ouroura, A.; Phillips, P.E.; Richards, B.; Wenzel, K.W.; Zhang, Z.M.

1994-01-01

Regression analysis has been performed on a number of measured profiles including temperature and density vs. nominal macroscopic operating parameters for TEXT tokamak (pre-upgrade) ohmic plasmas. The resulting simple empirical model has enabled the authors to quickly approximate profiles of electron temperature and density, ion temperature, and soft x-ray brightness, as well as the scalar quantities: total radiated power, q=1 radius, sawtooth period and amplitude, and energy confinement time as a power law of toroidal field, plasma current, chord average density, and fueling gas atomic weight. The model profiles are only applicable to the plasma interior, i.e. within the limiter radius. In most cases the predicted model profiles are within the experimental error bars of measured profiles and are more accurate at predicting profile variation for small operating parameter changes than the measured profiles

The application of image acquisition and processing technology in measurement of beam profile on particle accelerator

International Nuclear Information System (INIS)

Nie Zhenpeng; Zheng Yong; Shen Zhiqing; Wang Shaoming

2000-01-01

An introduction is given to the real-time measuring method which can measure the intensity and profile of the beam by a scintillator screen on HIRFL (Heavy Ion Research Facility of Lanzhou). Hardware structure is described briefly, methods of the software design are mainly presented. The system can make a dynamic analysis on the faculae image and has many advantages, such as good reliability, high precision, intuitional measurement, friendly interface of the application software etc. Finally some results of measurement are given

Minimal interference beam size/profile measurement techniques applicable to the Collider

International Nuclear Information System (INIS)

Nexsen, W.; Dutt, S.; Kauffmann, S.; Lebedev, V.; Maschke, A.; Mokhov, N.; Richardson, R.; Tsyganov, E.; Zinchenko, A.

1993-05-01

The imaging of synchrotron radiation (SR) has been suggested as a technique for providing a continuous, non-interfering monitor of the beam profile in the Collider rings at the Superconducting Super Collider. A closer examination has raised questions concerning the applicability of SR imaging in this case because of the diffraction broadening of the image, the requirements for axial space and location in the lattice, and the complexity of the system. We have surveyed the known, alternative, minimal interference techniques for measuring beam size and have evaluated them for possible Collider usage. We conclude that of the approaches that appear feasible, all require at least some development for our usage and that the development of an electron beam probe offers the best promise. We recommend that flying wires be used for cross-checking and calibrating the electron beam probe diagnostic and for luminosity measurements when the highest accuracy is required, but flying wires should not be used as the primary diagnostic because of their limited lifetime

Safety and security profiles of industry networks used in safety- critical applications

Directory of Open Access Journals (Sweden)

Mária FRANEKOVÁ

2008-01-01

Full Text Available The author describes the mechanisms of safety and security profiles of industry and communication networks used within safety – related applications in technological and information levels of process control recommended according to standards IEC 61784-3,4. Nowadays the number of vendors of the safety – related communication technologies who guarantees besides the standard communication, the communication amongst the safety – related equipment according to IEC 61508 is increasing. Also the number of safety – related products is increasing, e. g. safety Fieldbus, safety PLC, safety curtains, safety laser scanners, safety buttons, safety relays and other. According to world survey the safety Fieldbus denoted the highest growth from all manufactured safety products.The main part of this paper is the description of the safety-related Fieldbus communication system, which has to guaranty Safety Integrity Level.

LASER POINTER DETECTION BASED ON INTENSITY PROFILE ANALYSIS FOR APPLICATION IN TELECONSULTATION

Directory of Open Access Journals (Sweden)

NAIREEN IMTIAZ

2017-08-01

Full Text Available Telemedicine is application of electronic communication to deliver medical care remotely. An important aspect of telemedicine is teleconsultation which involves obtaining the professional opinion of a healthcare provider. One of the ways to improve eleconsultation is to equip the remote specialist via control of a laser pointer, located in the consultation area to provide a means of gesture. As such, accurate detection of laser spot is crucial in such systems as they rely on visual feedback, which enables the specialist in a remote site to control and point the laser in the active location using a standard mouse. The main issue in laser spot detection in a natural environment is the distinguishability of a laser point image from other bright regions and glare due to camera saturation. This problem remains unsolved without extensive computing and use of hardware filters. In this paper a hybrid algorithm is described which is aimed to work with natural indoor environment while limiting computation. This algorithm combines thresholding and blob evaluation methods with a novel image intensity profile comparison method based on linear regression. A comparison of the algorithm has been done with existing approaches. The developed algorithm shows a higher accuracy and faster execution time making it an ideal candidate for real time detection applications.

Measurement of temperature profiles in process-applications using fibre-optical methods; Prozessgeeignete Temperaturprofilmessungen mit faseroptischen Methoden

Energy Technology Data Exchange (ETDEWEB)

Seefeld, P. [Endress und Hauser Wetzer GmbH und Co.KG, Nesselwang (Germany)

2008-07-01

Fibre-optical temperature measuring methods are offering an approach to detect temperature profiles. According to the NAMUR-Technology-Roadmap the detection of temperature profiles is representing an increased benefit. Intrinsic fibre-optical temperature measuring techniques are presented, known as OTDRmethod (Optical tine domain reflectometry) facilitating a distributed temperature measurement method that allows a resolution in the range of decimetres. For the purpose of such applications a suitable photoncounting device comprises mechanical robust fibre-optical components, 3 db Coupler, referenced Laser- Diode, Y-Coupler with integrated band-filter and APD (Avalanche Diode) used in a detection module. A VHDL-coded FBGA-board provides a basic control-device for - a Laser-Driver to generate adjustable exiting-pulses in the range of nanoseconds at rates up to 100 kHz. - a Photon-Counting module with a minimum opening width in the range of one nanosecond - that permits the co-addition of the photon-counts derived from the spectral resolved Stokes and Anti-Stokes band. (orig.)

Developing a univariate approach to phase-I monitoring of fuzzy quality profiles

Directory of Open Access Journals (Sweden)

Kazem Noghondarian

2012-10-01

Full Text Available In many real-world applications, the quality of a process or a particular product can be characterized by a functional relationship called profile. A profile builds the relationships between a response quality characteristic and one or more explanatory variables. Monitoring the quality of a profile is implemented to understand and to verify the stability of this functional relationship over time. In some real applications, a fuzzy linear regression model can represent the profile adequately where the response quality characteristic is fuzzy. The purpose of this paper is to develop an approach for monitoring process/product profiles in fuzzy environment. A model in fuzzy linear regression is developed to construct the quality profiles by using linear programming and then fuzzy individuals and moving-range (I-MR control charts are developed to monitor both intercept and slope of fuzzy profiles to achieve an in-control process. A case study in customer satisfaction is presented to show the application of our approach and to express the sensitivity analysis of parameters for building a fuzzy profile.

Single-cell gene-expression profiling and its potential diagnostic applications

Czech Academy of Sciences Publication Activity Database

Stahlberg, A.; Kubista, Mikael; Aman, P.

2011-01-01

Roč. 11, č. 7 (2011), s. 735-740 ISSN 1473-7159 R&D Projects: GA ČR(CZ) GAP303/10/1338; GA ČR(CZ) GA301/09/1752 Institutional research plan: CEZ:AV0Z50520701 Keywords : gene-expression profiling * RT-qPCR * single-cell gene-expression profiling Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 4.859, year: 2011

Applicability analysis of hexahedral hollow profiles as component elements of supporting systems for gondola cars

Directory of Open Access Journals (Sweden)

O. V. Fomin

2014-12-01

Full Text Available Purpose. The purpose of work is presentation of features and results of the conducted works on determination of introduction expedience of hexahedral hollow profiles as the component elements of the modern supporting systems of railway freight gondola cars. Methodology. During the research an introduction methodology of different types of profiles as alternative to the existent supporting elements of the body module for freight car was used. This methodology had been developed by the author before. It is oriented to the reduction in material consumption and providing of strength requirements and operating reliability of the car design under study. The developed methodology includes the procedures of admissible values calculation of the resistance moments of the section of the hexahedral hollow profile, which is being introduced. It also includes the determination of optimum (i.e. characterized by the minimum material consumption when meeting the durability requirements values of height and minimum thickness of profile in the conditions of construction limitations. At the same time the admissible resistance moments are calculated as such, which are equal to the value of existent implementation of supporting element or as such that are determined taking into account the surplus design reserve. The first direction is applied in this work. Findings. As a result of the conducted research the introduction expedience of hexahedral hollow profiles as vertical rods of the lateral and latitude belts of the walls of the butt-end freight gondola cars is grounded and the optimum parameters of such replacements are determined. Originality. The problem of the use expedience of hexahedral hollow profiles as the supporting elements of the freight gondola cars bodies was first considered in the article. To solve this problem the mathematical models describing the dependence of basic strength and mass indexes of the proper profiles on varying the geometrical

ePRO-MP: A Tool for Profiling and Optimizing Energy and Performance of Mobile Multiprocessor Applications

Directory of Open Access Journals (Sweden)

Wonil Choi

2009-01-01

Full Text Available For mobile multiprocessor applications, achieving high performance with low energy consumption is a challenging task. In order to help programmers to meet these design requirements, system development tools play an important role. In this paper, we describe one such development tool, ePRO-MP, which profiles and optimizes both performance and energy consumption of multi-threaded applications running on top of Linux for ARM11 MPCore-based embedded systems. One of the key features of ePRO-MP is that it can accurately estimate the energy consumption of multi-threaded applications without requiring a power measurement equipment, using a regression-based energy model. We also describe another key benefit of ePRO-MP, an automatic optimization function, using two example problems. Using the automatic optimization function, ePRO-MP can achieve high performance and low power consumption without programmer intervention. Our experimental results show that ePRO-MP can improve the performance and energy consumption by 6.1% and 4.1%, respectively, over a baseline version for the co-running applications optimization example. For the producer-consumer application optimization example, ePRO-MP improves the performance and energy consumption by 60.5% and 43.3%, respectively over a baseline version.

Application of the British Food Standards Agency nutrient profiling system in a French food composition database.

Science.gov (United States)

Julia, Chantal; Kesse-Guyot, Emmanuelle; Touvier, Mathilde; Méjean, Caroline; Fezeu, Léopold; Hercberg, Serge

2014-11-28

Nutrient profiling systems are powerful tools for public health initiatives, as they aim at categorising foods according to their nutritional quality. The British Food Standards Agency (FSA) nutrient profiling system (FSA score) has been validated in a British food database, but the application of the model in other contexts has not yet been evaluated. The objective of the present study was to assess the application of the British FSA score in a French food composition database. Foods from the French NutriNet-Santé study food composition table were categorised according to their FSA score using the Office of Communication (OfCom) cut-off value ('healthier' ≤ 4 for foods and ≤ 1 for beverages; 'less healthy' >4 for foods and >1 for beverages) and distribution cut-offs (quintiles for foods, quartiles for beverages). Foods were also categorised according to the food groups used for the French Programme National Nutrition Santé (PNNS) recommendations. Foods were weighted according to their relative consumption in a sample drawn from the NutriNet-Santé study (n 4225), representative of the French population. Classification of foods according to the OfCom cut-offs was consistent with food groups described in the PNNS: 97·8 % of fruit and vegetables, 90·4 % of cereals and potatoes and only 3·8 % of sugary snacks were considered as 'healthier'. Moreover, variability in the FSA score allowed for a discrimination between subcategories in the same food group, confirming the possibility of using the FSA score as a multiple category system, for example as a basis for front-of-pack nutrition labelling. Application of the FSA score in the French context would adequately complement current public health recommendations.

The atypical excretion profile of meldonium: Comparison of urinary detection windows after single- and multiple-dose application in healthy volunteers.

Science.gov (United States)

Görgens, Christian; Guddat, Sven; Bosse, Christina; Geyer, Hans; Pop, Valentin; Schänzer, Wilhelm; Thevis, Mario

2017-05-10

Following a one-year monitoring program providing unequivocal analytical evidence for a high prevalence in international elite sports, meldonium has been included in the World Anti-Doping Agency's (WADA) list of prohibited substances that came into effect on 1 January 2016. Despite of the polar and hydrophilic nature of the molecule, an unusual long detection window was observed in pilot elimination studies. Consequently, in the present study, urinary excretion profiles after single-dose (5 volunteers, 1×500mg) and multiple-dose oral application (5 volunteers; 2×500mg/day for 6days) were determined in order to facilitate the result management concerning meldonium findings in doping controls. Particularly the option to differentiate between recent use and tapering concentrations was studied. Urinary meldonium concentrations were determined using an analytical approach based on hydrophilic interaction liquid chromatography and high resolution tandem mass spectrometry. The study corroborates the hypothesis of a non-linear, dose-depended and biphasic excretion profile after oral application of meldonium and demonstrates that urinary detection windows are of considerable extent with up to 65 and 117days (concentrations>LOQ of 10ng/mL) following single- and multiple-dose applications, respectively. Copyright © 2017 Elsevier B.V. All rights reserved.

DYNAMIC MEMORY ALLOCATION – CLR PROFILER

Directory of Open Access Journals (Sweden)

Adrian LUPASC

2014-06-01

Full Text Available At the present time, information systems are an important component in the development of many activities, due to their ability of managing a large amount of data and performing complex operations in a very short time. In this regard, very important is the correct management of all available resources, especially memory management. Haven’t happened to test an application, but it runs out of memory? This paper is trying to explain some of the situations causing those problems and also is trying to find some solutions for fixing them. Concluding, the purpose of this paper is to emphasize on one hand the importance of using a memory profiler in the development of your applications and on the other hand, the advantages brought by CLR Profiler on your .NET applications.

A Low Profile Ultrawide Band Monopole Antenna for Wearable Applications

Directory of Open Access Journals (Sweden)

Srinivas Doddipalli

2017-01-01

Full Text Available A low profile pentagonal shaped monopole antenna is designed and presented for wearable applications. The main objective of this paper is to design a miniaturized ultrawide band monopole planar antenna which can work efficiently in free space but also on the surface of the human body. The impact of human tissues on antenna performance is explained using the proposed pentagonal monopole antenna. The antenna is designed with a pentagonal radiator and a matched feed line of 50 ohm and square slots are integrated on defected ground of FR4 substrate with a size of 15 mm × 25 mm to achieve ultrawide band (UWB performance in free space and human proximity. This overall design will enhance the antenna performance with wide bandwidth ranging from 2.9 GHz to 11 GHz. Specific absorption rate (SAR of the proposed antenna on dispersive phantom model is also measured to observe the exposure of electromagnetic energy on human tissues. The simulated and measured results of the proposed antenna exhibit wide bandwidth and radiation characteristics in both free space and human proximity.

Multidimensional profiles of health status: an application of the grade of membership model to the world health survey.

Directory of Open Access Journals (Sweden)

Alessandra Andreotti

Full Text Available BACKGROUND: The World Health Organization (WHO conducted the World Health Survey (WHS between 2002 and 2004 in 70 countries to provide cross-population comparable data on health, health-related outcomes and risk factors. The aim of this study was to apply Grade of Membership (GoM modelling as a means to condense extensive health information from the WHS into a set of easily understandable health profiles and to assign the degree to which an individual belongs to each profile. PRINCIPAL FINDINGS: This paper described the application of the GoM models to summarize population health status using World Health Survey data. Grade of Membership analysis is a flexible, non-parametric, multivariate method, used to calculate health profiles from WHS self-reported health state and health conditions. The WHS dataset was divided into four country economic categories based on the World Bank economic groupings (high, upper-middle, lower-middle and low income economies for separate GoM analysis. Three main health profiles were produced for each of the four areas: I. Robust; II. Intermediate; III. Frail; moreover population health, wealth and inequalities are defined for countries in each economic area as a means to put the health results into perspective. CONCLUSIONS: These analyses have provided a robust method to better understand health profiles and the components which can help to identify healthy and non-healthy individuals. The obtained profiles have described concrete levels of health and have clearly delineated characteristics of healthy and non-healthy respondents. The GoM results provided both a useable way of summarising complex individual health information and a selection of intermediate determinants which can be targeted for interventions to improve health. As populations' age, and with limited budgets for additional costs for health care and social services, applying the GoM methods may assist with identifying higher risk profiles for decision

An Interoperability Framework and Capability Profiling for Manufacturing Software

Science.gov (United States)

Matsuda, M.; Arai, E.; Nakano, N.; Wakai, H.; Takeda, H.; Takata, M.; Sasaki, H.

ISO/TC184/SC5/WG4 is working on ISO16100: Manufacturing software capability profiling for interoperability. This paper reports on a manufacturing software interoperability framework and a capability profiling methodology which were proposed and developed through this international standardization activity. Within the context of manufacturing application, a manufacturing software unit is considered to be capable of performing a specific set of function defined by a manufacturing software system architecture. A manufacturing software interoperability framework consists of a set of elements and rules for describing the capability of software units to support the requirements of a manufacturing application. The capability profiling methodology makes use of the domain-specific attributes and methods associated with each specific software unit to describe capability profiles in terms of unit name, manufacturing functions, and other needed class properties. In this methodology, manufacturing software requirements are expressed in terns of software unit capability profiles.

Application of metabolite profiling and antioxidant activity in ...

African Journals Online (AJOL)

This paper investigates the effect of processing and extraction method on chemical profiles and antioxidant activity of Malaysian stingless bee propolis. High Performance Thin Layer Chromatography (HPTLC) analysis in combination with chemometric shows that some of the compounds were degraded or not detected in ...

Personal summarization from profile networks

Institute of Scientific and Technical Information of China (English)

Zhongqing WANG; Shoushan LI; Guodong ZHOU

2017-01-01

Personal profile information on social media like Linkedln.com and Facebook.com is at the core of many interesting applications,such as talent recommendation and contextual advertising.However,personal profiles usually lack consistent organization confronted with the large amount of available information.Therefore,it is always a challenge for people to quickly find desired information from them.In this paper,we address the task of personal profile summarization by leveraging both textual information and social connection information in social networks from both unsupervised and supervised learning paradigms.Here,using social connection information is motivated by the intuition that people with similar academic,business or social background (e.g.,comajor,co-university,and co-corporation) tend to have similar experiences and should have similar summaries.For unsupervised learning,we propose a collective ranking approach,called SocialRank,to combine textual information in an individual profile and social context information from relevant profiles in generating a personal profile summary.For supervised learning,we propose a collective factor graph model,called CoFG,to summarize personal profiles with local textual attribute functions and social connection factors.Extensive evaluation on a large dataset from LinkedIn.com demonstrates the usefulness of social connection information in personal profile summarization and the effectiveness of our proposed unsupervised and supervised learning approaches.

Personalization in E-commerce using profiles similarity

Directory of Open Access Journals (Sweden)

Radu LIXANDROIU

2015-06-01

Full Text Available Understanding the use needs is one of the key factors of an online project. If these needs are quickly identified, the customer can be offered the best products immediately. Creating profiles allows the identification and communication of needs efficiently and effectively. Basically if these profiles are well established, it remains to identify just which is the closest profile to the online client. Profiling is a useful tool in marketing, increasing the functionality of sales application. These tools fall into customer-oriented tools, together with the analytical techniques ones and those suggesting the desired products.

Application software profiles 2010

Energy Technology Data Exchange (ETDEWEB)

Anon.

2010-04-15

This article presented information on new software applications designed to facilitate petroleum exploration, drilling and production activities. Computer modelling and analysis enables oil and gas producers to characterize reservoirs, estimate reserves forecast production, plan operations and manage assets. Seven Calgary-based organizations were highlighted along with their sophisticated software tools, the applications and the new features available in each product. The geoSCOUT version 7.7 by GeoLOGIC Systems Ltd. integrates public and proprietary data on wells, well logs, reserves, pipelines, production, ownership and seismic location data. The Value Navigator and AFE Navigator by Energy Navigator provides control over reserves, production and cash flow forecasting. FAST Harmony, FAST Evolution, FAST CBM, FAST FieldNotes, Fast Piper, FAST RTA, FAST VirtuWell and FAST WellTest by Fekete Associates Inc. provide reserve evaluations for reservoir engineering projects and production data analysis. The esi.manage software program by 3esi improves business results for upstream oil and gas companies through enhanced decision making and workforce effectiveness. WELLFLO, PIPEFLO, FORGAS, OLGA, Drillbench, and MEPO wellbore solutions by Neotec provide unique platforms for flow simulation to optimize oil and gas production systems. Petrel, ECLIPSE, Avocet, PipeSim and Merak software tools by Schlumberger Information Solutions are petroleum systems modelling tools for geologic mapping, visualization modelling and reservoir engineering. StudioSL by Streamsim Technologies Inc. is a modelling tool for optimizing flood management. figs.

Virtual environment assessment for laser-based vision surface profiling

Science.gov (United States)

ElSoussi, Adnane; Al Alami, Abed ElRahman; Abu-Nabah, Bassam A.

2015-03-01

Oil and gas businesses have been raising the demand from original equipment manufacturers (OEMs) to implement a reliable metrology method in assessing surface profiles of welds before and after grinding. This certainly mandates the deviation from the commonly used surface measurement gauges, which are not only operator dependent, but also limited to discrete measurements along the weld. Due to its potential accuracy and speed, the use of laser-based vision surface profiling systems have been progressively rising as part of manufacturing quality control. This effort presents a virtual environment that lends itself for developing and evaluating existing laser vision sensor (LVS) calibration and measurement techniques. A combination of two known calibration techniques is implemented to deliver a calibrated LVS system. System calibration is implemented virtually and experimentally to scan simulated and 3D printed features of known profiles, respectively. Scanned data is inverted and compared with the input profiles to validate the virtual environment capability for LVS surface profiling and preliminary assess the measurement technique for weld profiling applications. Moreover, this effort brings 3D scanning capability a step closer towards robust quality control applications in a manufacturing environment.

Application of modified analytical function for approximation and computer simulation of diffraction profile

International Nuclear Information System (INIS)

Marrero, S. I.; Turibus, S. N.; Assis, J. T. De; Monin, V. I.

2011-01-01

Data processing of the most of diffraction experiments is based on determination of diffraction line position and measurement of broadening of diffraction profile. High precision and digitalisation of these procedures can be resolved by approximation of experimental diffraction profiles by analytical functions. There are various functions for these purposes both simples, like Gauss function, but no suitable for wild range of experimental profiles and good approximating functions but complicated for practice using, like Vougt or PersonVII functions. Proposed analytical function is modified Cauchy function which uses two variable parameters allowing describing any experimental diffraction profile. In the presented paper modified function was applied for approximation of diffraction lines of steels after various physical and mechanical treatments and simulation of diffraction profiles applied for study of stress gradients and distortions of crystal structure. (Author)

Size and shape-dependent cytotoxicity profile of gold nanoparticles for biomedical applications.

Science.gov (United States)

Woźniak, Anna; Malankowska, Anna; Nowaczyk, Grzegorz; Grześkowiak, Bartosz F; Tuśnio, Karol; Słomski, Ryszard; Zaleska-Medynska, Adriana; Jurga, Stefan

2017-06-01

Metallic nanoparticles, in particular gold nanoparticles (AuNPs), offer a wide spectrum of applications in biomedicine. A crucial issue is their cytotoxicity, which depends greatly on various factors, including morphology of nanoparticles. Because metallic nanoparticles have an effect on cell membrane integrity, their shape and size may affect the viability of cells, due to their different geometries as well as physical and chemical interactions with cell membranes. Variations in the size and shape of gold nanoparticles may indicate particular nanoparticle morphologies that provide strong cytotoxicity effects. Synthesis of different sized and shaped bare AuNPs was performed with spherical (~ 10 nm), nanoflowers (~ 370 nm), nanorods (~ 41 nm), nanoprisms (~ 160 nm) and nanostars (~ 240 nm) morphologies. These nanostructures were characterized and interacting with cancer (HeLa) and normal (HEK293T) cell lines and cell viability tests were performed by WST-1 tests and fluorescent live/dead cell imaging experiments. It was shown that various shapes and sizes of gold nanostructures may affect the viability of the cells. Gold nanospheres and nanorods proved to be more toxic than star, flower and prism gold nanostructures. This may be attributed to their small size and aggregation process. This is the first report concerning a comparison of cytotoxic profile in vitro with a wide spectrum of bare AuNPs morphology. The findings show their possible use in biomedical applications.

Active core profile and transport modification by application of ion Bernstein wave power in the Princeton Beta Experiment-Modification

Science.gov (United States)

LeBlanc, B.; Batha, S.; Bell, R.; Bernabei, S.; Blush, L.; de la Luna, E.; Doerner, R.; Dunlap, J.; England, A.; Garcia, I.; Ignat, D.; Isler, R.; Jones, S.; Kaita, R.; Kaye, S.; Kugel, H.; Levinton, F.; Luckhardt, S.; Mutoh, T.; Okabayashi, M.; Ono, M.; Paoletti, F.; Paul, S.; Petravich, G.; Post-Zwicker, A.; Sauthoff, N.; Schmitz, L.; Sesnic, S.; Takahashi, H.; Talvard, M.; Tighe, W.; Tynan, G.; von Goeler, S.; Woskov, P.; Zolfaghari, A.

1995-03-01

Application of Ion Bernstein Wave Heating (IBWH) into the Princeton Beta Experiment-Modification (PBX-M) [Phys. Fluids B 2, 1271 (1990)] tokamak stabilizes sawtooth oscillations and generates peaked density profiles. A transport barrier, spatially correlated with the IBWH power deposition profile, is observed in the core of IBWH-assisted neutral beam injection (NBI) discharges. A precursor to the fully developed barrier is seen in the soft x-ray data during edge localized mode (ELM) activity. Sustained IBWH operation is conducive to a regime where the barrier supports large ∇ne, ∇Te, ∇νφ, and ∇Ti, delimiting the confinement zone. This regime is reminiscent of the H(high) mode, but with a confinement zone moved inward. The core region has better than H-mode confinement while the peripheral region is L(low)-mode-like. The peaked profile enhances NBI core deposition and increases nuclear reactivity. An increase in central Ti results from χi reduction (compared to the H mode) and better beam penetration. Bootstrap current fractions of up to 0.32-0.35 locally and 0.28 overall were obtained when an additional NBI burst is applied to this plasma.

Active core profile and transport modification by application of ion Bernstein wave power in the Princeton Beta Experiment-Modification

International Nuclear Information System (INIS)

LeBlanc, B.; Batha, S.; Bell, R.; Bernabei, S.; Blush, L.; de la Luna, E.; Doerner, R.; Dunlap, J.; England, A.; Garcia, I.; Ignat, D.; Isler, R.; Jones, S.; Kaita, R.; Kaye, S.; Kugel, H.; Levinton, F.; Luckhardt, S.; Mutoh, T.; Okabayashi, M.; Ono, M.; Paoletti, F.; Paul, S.; Petravich, G.; Post-Zwicker, A.; Sauthoff, N.; Schmitz, L.; Sesnic, S.; Takahashi, H.; Talvard, M.; Tighe, W.; Tynan, G.; von Goeler, S.; Woskov, P.; Zolfaghari, A.

1995-01-01

Application of Ion Bernstein Wave Heating (IBWH) into the Princeton Beta Experiment-Modification (PBX-M) [Phys. Fluids B 2, 1271 (1990)] tokamak stabilizes sawtooth oscillations and generates peaked density profiles. A transport barrier, spatially correlated with the IBWH power deposition profile, is observed in the core of IBWH-assisted neutral beam injection (NBI) discharges. A precursor to the fully developed barrier is seen in the soft x-ray data during edge localized mode (ELM) activity. Sustained IBWH operation is conducive to a regime where the barrier supports large ∇n e , ∇T e , ∇ν φ , and ∇T i , delimiting the confinement zone. This regime is reminiscent of the H(high) mode, but with a confinement zone moved inward. The core region has better than H-mode confinement while the peripheral region is L(low)-mode-like. The peaked profile enhances NBI core deposition and increases nuclear reactivity. An increase in central T i results from χ i reduction (compared to the H mode) and better beam penetration. Bootstrap current fractions of up to 0.32--0.35 locally and 0.28 overall were obtained when an additional NBI burst is applied to this plasma

Application of neutron activation analysis for the determination of implantation profiles of phosphorus in semiconductor grade silicon

International Nuclear Information System (INIS)

Jaskolska, H.; Rowinska, L.; Walis, L.

1977-01-01

A method for the determination of concentration profiles of phosphorus in silicon by neutron activation has been elaborated. It is based on the previously described extraction methods, in which phosphorus is extracted as phosphomolybdic complex with isoamyl alcohol. It was suitably modified and Au and Ta holdback carriers were used in order to diminish the extraction of these elements together with phosphorus. The method permits to achieve decontamination factors of 10 2 -10 3 for the elements found in the Si plates examined. The yield of phosphorus separation is nearly constant and amounts to 84%. Layers are removed from the annealed plate by anodic oxidation and by dissolving the oxide formed on the surface in diluted hydrofluoric acid. The thickness of the removed layers is determined from previously prepared calibration curves. The lower limit of determination is of the order 10 -11 g P. Two groups of errors have been discussed. The suitability of autoradiography to the determination of concentration profiles has been demonstrated. Some applications of the method are suggested. (T.G.)

Data Transfer Advisor with Transport Profiling Optimization

Energy Technology Data Exchange (ETDEWEB)

Rao, Nageswara S. [ORNL; Liu, Qiang [ORNL; Yun, Daqing [Harrisburg University; Wu, Chase Qishi [New Jersey Institute of Technology; Kettimuthu, R. [Argonne National Laboratory (ANL); Jung, Eun-sung [Argonne National Laboratory (ANL)

2017-11-01

The network infrastructures have been rapidly upgraded in many high-performance networks (HPNs). However, such infrastructure investment has not led to corresponding performance improvement in big data transfer, especially at the application layer, largely due to the complexity of optimizing transport control on end hosts. We design and implement ProbData, a PRofiling Optimization Based DAta Transfer Advisor, to help users determine the most effective data transfer method with the most appropriate control parameter values to achieve the best data transfer performance. ProbData employs a profiling optimization based approach to exploit the optimal operational zone of various data transfer methods in support of big data transfer in extreme scale scientific applications. We present a theoretical framework of the optimized profiling approach employed in ProbData as wellas its detailed design and implementation. The advising procedure and performance benefits of ProbData are illustrated and evaluated by proof-of-concept experiments in real-life networks.

Development and Applications of Time of Flight Neutron Depth Profiling

International Nuclear Information System (INIS)

Cady, Bingham; Unlu, Kenan

2005-01-01

The depth profiles of intentional or intrinsic constituents of a sample provide valuable information for the characterization of materials. For example, the subtle differences in spatial distribution and composition of many chemical species in the near surface region and across interfacial boundaries can significantly alter the electronic and optical properties of materials. A number of analytical techniques for depth profiling have been developed during the last two decades. neutron Depth Profiling (NDP) is one of the leading analytical techniques. The NDP is a nondestructive near surface technique that utilizes thermal/cold neutron beam to measure the concentration of specific light elements versus their depth in materials. The depth is obtained from the energy loss of protons, alphas or recoil atoms in substrate materials. Since the charged particle energy determination using surface barrier detector is used for NDP, the depth resolution is highly dependent on the detectors an d detection instruments. The depth resolutions of a few tens of nm are achieved with available NDP facilities in the world. However, the performance of NDP needs to be improved in order to obtain a few A depth resolutions

One- and two-dimensional dopant/carrier profiling for ULSI

Science.gov (United States)

Vandervorst, W.; Clarysse, T.; De Wolf, P.; Trenkler, T.; Hantschel, T.; Stephenson, R.; Janssens, T.

1998-11-01

Dopant/carrier profiles constitute the basis of the operation of a semiconductor device and thus play a decisive role in the performance of a transistor and are subjected to the same scaling laws as the other constituents of a modern semiconductor device and continuously evolve towards shallower and more complex configurations. This evolution has increased the demands on the profiling techniques in particular in terms of resolution and quantification such that a constant reevaluation and improvement of the tools is required. As no single technique provides all the necessary information (dopant distribution, electrical activation,..) with the requested spatial and depth resolution, the present paper attempts to provide an assessment of those tools which can be considered as the main metrology technologies for ULSI-applications. For 1D-dopant profiling secondary ion mass spectrometry (SIMS) has progressed towards a generally accepted tool meeting the requirements. For 1D-carrier profiling spreading resistance profiling and microwave surface impedance profiling are envisaged as the best choices but extra developments are required to promote them to routinely applicable methods. As no main metrology tool exist for 2D-dopant profiling, main emphasis is on 2D-carrier profiling tools based on scanning probe microscopy. Scanning spreading resistance (SSRM) and scanning capacitance microscopy (SCM) are the preferred methods although neither of them already meets all the requirements. Complementary information can be extracted from Nanopotentiometry which samples the device operation in more detail. Concurrent use of carrier profiling tools, Nanopotentiometry, analysis of device characteristics and simulations is required to provide a complete characterization of deep submicron devices.

Development of a Climatology of Vertically Complete Wind Profiles from Doppler Radar Wind Profiler Systems

Science.gov (United States)

Barbre, Robert E., Jr.

2015-01-01

This paper describes in detail the QC and splicing methodology for KSC's 50- and 915-MHz DRWP measurements that generates an extensive archive of vertically complete profiles from 0.20-18.45 km. The concurrent POR from each archive extends from April 2000 to December 2009. MSFC NE applies separate but similar QC processes to each of the 50- and 915-MHz DRWP archives. DRWP literature and data examination provide the basis for developing and applying the automated and manual QC processes on both archives. Depending on the month, the QC'ed 50- and 915-MHz DRWP archives retain 52-65% and 16-30% of the possible data, respectively. The 50- and 915-MHz DRWP QC archives retain 84-91% and 85-95%, respectively, of all the available data provided that data exist in the non- QC'ed archives. Next, MSFC NE applies an algorithm to splice concurrent measurements from both DRWP sources. Last, MSFC NE generates a composite profile from the (up to) five available spliced profiles to effectively characterize boundary layer winds and to utilize all possible 915-MHz DRWP measurements at each timestamp. During a given month, roughly 23,000-32,000 complete profiles exist from 0.25-18.45 km from the composite profiles' archive, and approximately 5,000- 27,000 complete profiles exist from an archive utilizing an individual 915-MHz DRWP. One can extract a variety of profile combinations (pairs, triplets, etc.) from this sample for a given application. The sample of vertically complete DRWP wind measurements not only gives launch vehicle customers greater confidence in loads and trajectory assessments versus using balloon output, but also provides flexibility to simulate different DOL situations across applicable altitudes. In addition to increasing sample size and providing more flexibility for DOL simulations in the vehicle design phase, the spliced DRWP database provides any upcoming launch vehicle program with the capability to utilize DRWP profiles on DOL to compute vehicle steering

Beam envelope profile of non-centrosymmetric polygonal phase space

International Nuclear Information System (INIS)

Chen Yinbao; Xie Xi

1984-01-01

The general theory of beam envelope profile of non-centrosymmetric polygonal phase space is developed. By means of this theory the beam envelope profile of non-centrosymmetric polygonal phase space can be calculated directly. An example is carried out in detail to show the practical application of the theory

Optimizing UV laser focus profiles for improved MALDI performance.

Science.gov (United States)

Holle, Armin; Haase, Andreas; Kayser, Markus; Höhndorf, Jens

2006-06-01

Matrix assisted laser desorption/ionization (MALDI) applications, such as proteomics, genomics, clinical profiling and MALDI imaging, have created a growing demand for faster instrumentation. Since the commonly used nitrogen lasers have throughput and life span limitations, diode-pumped solid-state lasers are an alternative. Unfortunately this type of laser shows clear performance limitations in MALDI in terms of sensitivity, resolution and ease of use, for applications such as thin-layer sample preparations, acceptance of various matrices (e.g. DHB for glycopeptides) and MALDI imaging. While it is obvious that the MALDI process has some dependence on the characteristics of the laser used, it is unclear which features are the most critical in determining laser performance for MALDI. In this paper we show, for the first time, that a spatially structured laser beam profile in lieu of a Gaussian profile is of striking importance. This result enabled us to design diode-pumped Nd : YAG lasers that on various critical applications perform as well for MALDI as the nitrogen lasers and in some respects even better. The modulation of the beam profile appears to be a new parameter for optimizing the MALDI process. In addition, the results trigger new questions directing us to a better understanding of the MALDI process. Copyright (c) 2006 John Wiley & Sons, Ltd.

Changes in Amino Acid Profile in Roots of Glyphosate Resistant and Susceptible Soybean (Glycine max) Induced by Foliar Glyphosate Application.

Science.gov (United States)

Moldes, Carlos Alberto; Cantarelli, Miguel Angel; Camiña, José Manuel; Tsai, Siu Mui; Azevedo, Ricardo Antunes

2017-10-11

Amino acid profiles are useful to analyze the responses to glyphosate in susceptible and resistant soybean lines. Comparisons of profiles for 10 amino acids (Asp, Asn, Glu, Gln, Ser, His, Gly, Thr, Tyr, Leu) by HPLC in soybean roots were performed in two near isogenic pairs (four varieties). Foliar application of glyphosate was made to soybean plants after 5 weeks of seeding. Roots of four varieties were collected at 0 and 72 h after glyphosate application (AGA) for amino acid analysis by HPLC. Univariate analysis showed a significant increase of several amino acids in susceptible as well as resistant soybean lines; however, amino acids from the major pathways of carbon (C) and nitrogen (N) metabolism, such as Asp, Asn, Glu and Gln, and Ser, increased significantly in susceptible varieties at 72 h AGA. Multivariate analysis using principal component analysis (2D PCA and 3D PCA) allowed different groups to be identified and discriminated based on the soybean genetic origin, showing the amino acid responses on susceptible and resistant varieties. Based on the results, it is possible to infer that the increase of Asn, Asp, Glu, Gln, and Ser in susceptible varieties would be related to the deregulation of C and N metabolism, as well as changes in the growth mechanisms regulated by Ser.

Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile.

Science.gov (United States)

Rafiei, Pedram; Haddadi, Azita

2017-01-01

Docetaxel is a highly potent anticancer agent being used in a wide spectrum of cancer types. There are important matters of concern regarding the drug's pharmacokinetics related to the conventional formulation. Poly(lactide- co -glycolide) (PLGA) is a biocompatible/biodegradable polymer with variable physicochemical characteristics, and its application in human has been approved by the United States Food and Drug Administration. PLGA gives polymeric nanoparticles with unique drug delivery characteristics. The application of PLGA nanoparticles (NPs) as intravenous (IV) sustained-release delivery vehicles for docetaxel can favorably modify pharmacokinetics, biofate, and pharmacotherapy of the drug in cancer patients. Surface modification of PLGA NPs with poly(ethylene glycol) (PEG) can further enhance NPs' long-circulating properties. Herein, an optimized fabrication approach has been used for the preparation of PLGA and PLGA-PEG NPs loaded with docetaxel for IV application. Both types of NP formulations demonstrated in vitro characteristics that were considered suitable for IV administration (with long-circulating sustained-release purposes). NP formulations were IV administered to an animal model, and docetaxel's pharmacokinetic and biodistribution profiles were determined and compared between study groups. PLGA and PEGylated PLGA NPs were able to modify the pharmacokinetics and biodistribution of docetaxel. Accordingly, the mode of changes made to pharmacokinetics and biodistribution of docetaxel is attributed to the size and surface properties of NPs. NPs contributed to increased blood residence time of docetaxel fulfilling their role as long-circulating sustained-release drug delivery systems. Surface modification of NPs contributed to more pronounced docetaxel blood concentration, which confirms the role of PEG in conferring long-circulation properties to NPs.

Sample preparation optimization in fecal metabolic profiling.

Science.gov (United States)

Deda, Olga; Chatziioannou, Anastasia Chrysovalantou; Fasoula, Stella; Palachanis, Dimitris; Raikos, Νicolaos; Theodoridis, Georgios A; Gika, Helen G

2017-03-15

Metabolomic analysis of feces can provide useful insight on the metabolic status, the health/disease state of the human/animal and the symbiosis with the gut microbiome. As a result, recently there is increased interest on the application of holistic analysis of feces for biomarker discovery. For metabolomics applications, the sample preparation process used prior to the analysis of fecal samples is of high importance, as it greatly affects the obtained metabolic profile, especially since feces, as matrix are diversifying in their physicochemical characteristics and molecular content. However there is still little information in the literature and lack of a universal approach on sample treatment for fecal metabolic profiling. The scope of the present work was to study the conditions for sample preparation of rat feces with the ultimate goal of the acquisition of comprehensive metabolic profiles either untargeted by NMR spectroscopy and GC-MS or targeted by HILIC-MS/MS. A fecal sample pooled from male and female Wistar rats was extracted under various conditions by modifying the pH value, the nature of the organic solvent and the sample weight to solvent volume ratio. It was found that the 1/2 (w f /v s ) ratio provided the highest number of metabolites under neutral and basic conditions in both untargeted profiling techniques. Concerning LC-MS profiles, neutral acetonitrile and propanol provided higher signals and wide metabolite coverage, though extraction efficiency is metabolite dependent. Copyright © 2016 Elsevier B.V. All rights reserved.

Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction

Energy Technology Data Exchange (ETDEWEB)

Wang, Jing; Ma, Zihao; Carr, Steven A.; Mertins, Philipp; Zhang, Hui; Zhang, Zhen; Chan, Daniel W.; Ellis, Matthew J. C.; Townsend, R. Reid; Smith, Richard D.; McDermott, Jason E.; Chen, Xian; Paulovich, Amanda G.; Boja, Emily S.; Mesri, Mehdi; Kinsinger, Christopher R.; Rodriguez, Henry; Rodland, Karin D.; Liebler, Daniel C.; Zhang, Bing

2016-11-11

Coexpression of mRNAs under multiple conditions is commonly used to infer cofunctionality of their gene products despite well-known limitations of this “guilt-by-association” (GBA) approach. Recent advancements in mass spectrometry-based proteomic technologies have enabled global expression profiling at the protein level; however, whether proteome profiling data can outperform transcriptome profiling data for coexpression based gene function prediction has not been systematically investigated. Here, we address this question by constructing and analyzing mRNA and protein coexpression networks for three cancer types with matched mRNA and protein profiling data from The Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC). Our analyses revealed a marked difference in wiring between the mRNA and protein coexpression networks. Whereas protein coexpression was driven primarily by functional similarity between coexpressed genes, mRNA coexpression was driven by both cofunction and chromosomal colocalization of the genes. Functionally coherent mRNA modules were more likely to have their edges preserved in corresponding protein networks than functionally incoherent mRNA modules. Proteomic data strengthened the link between gene expression and function for at least 75% of Gene Ontology (GO) biological processes and 90% of KEGG pathways. A web application Gene2Net (http://cptac.gene2net.org) developed based on the three protein coexpression networks revealed novel gene-function relationships, such as linking ERBB2 (HER2) to lipid biosynthetic process in breast cancer, identifying PLG as a new gene involved in complement activation, and identifying AEBP1 as a new epithelial-mesenchymal transition (EMT) marker. Our results demonstrate that proteome profiling outperforms transcriptome profiling for coexpression based gene function prediction. Proteomics should be integrated if not preferred in gene function and human disease studies

Criminal profiling as expert witness evidence: The implications of the profiler validity research.

Science.gov (United States)

Kocsis, Richard N; Palermo, George B

The use and development of the investigative tool colloquially known as criminal profiling has steadily increased over the past five decades throughout the world. Coupled with this growth has been a diversification in the suggested range of applications for this technique. Possibly the most notable of these has been the attempted transition of the technique from a tool intended to assist police investigations into a form of expert witness evidence admissible in legal proceedings. Whilst case law in various jurisdictions has considered with mutual disinclination the evidentiary admissibility of criminal profiling, a disjunction has evolved between these judicial examinations and the scientifically vetted research testing the accuracy (i.e., validity) of the technique. This article offers an analysis of the research directly testing the validity of the criminal profiling technique and the extant legal principles considering its evidentiary admissibility. This analysis reveals that research findings concerning the validity of criminal profiling are surprisingly compatible with the extant legal principles. The overall conclusion is that a discrete form of crime behavioural analysis is supported by the profiler validity research and could be regarded as potentially admissible expert witness evidence. Finally, a number of theoretical connections are also identified concerning the skills and qualifications of individuals who may feasibly provide such expert testimony. Copyright © 2016 Elsevier Ltd. All rights reserved.

Stationary neoclassical profiles of plasma parameters in stellarators

International Nuclear Information System (INIS)

Danilkin, I.S.; Mineev, A.B.

1991-01-01

Peculiarities of neoclassical model of heat and particle transfer, occuring by calculations of plasma stationary profile parameters in stellarators are considered. The main peculiarity out of all consists in ineadequate compatibility with real physical conditions on the boundary, requiring application of supplementary 'anomalous' transfer or special (but technically possible) adjustment of particle and heat sources to achieve solution in form of 'correct' monotonically sloping profile. It is stated, that neoclassical theory does not provide for well-known ambiguity of solutions for ambipolar electrical field by search of monotonous stationary profiles supported by outside sources

A two-dimensional statistical framework connecting thermodynamic profiles with filaments in the scrape off layer and application to experiments

Science.gov (United States)

Militello, F.; Farley, T.; Mukhi, K.; Walkden, N.; Omotani, J. T.

2018-05-01

A statistical framework was introduced in Militello and Omotani [Nucl. Fusion 56, 104004 (2016)] to correlate the dynamics and statistics of L-mode and inter-ELM plasma filaments with the radial profiles of thermodynamic quantities they generate in the Scrape Off Layer. This paper extends the framework to cases in which the filaments are emitted from the separatrix at different toroidal positions and with a finite toroidal velocity. It is found that the toroidal velocity does not affect the profiles, while the toroidal distribution of filament emission renormalises the waiting time between two events. Experimental data collected by visual camera imaging are used to evaluate the statistics of the fluctuations, to inform the choice of the probability distribution functions used in the application of the framework. It is found that the toroidal separation of the filaments is exponentially distributed, thus suggesting the lack of a toroidal modal structure. Finally, using these measurements, the framework is applied to an experimental case and good agreement is found.

A spectral profile multiplexed FBG sensor network with application to strain measurement in a Kevlar woven fabric

Science.gov (United States)

Guo, Guodong; Hackney, Drew; Pankow, Mark; Peters, Kara

2017-04-01

A spectral profile division multiplexed fiber Bragg grating (FBG) sensor network is described in this paper. The unique spectral profile of each sensor in the network is identified as a distinct feature to be interrogated. Spectrum overlap is allowed under working conditions. Thus, a specific wavelength window does not need to be allocated to each sensor as in a wavelength division multiplexed (WDM) network. When the sensors are serially connected in the network, the spectrum output is expressed through a truncated series. To track the wavelength shift of each sensor, the identification problem is transformed to a nonlinear optimization problem, which is then solved by a modified dynamic multi-swarm particle swarm optimizer (DMS-PSO). To demonstrate the application of the developed network, a network consisting of four FBGs was integrated into a Kevlar woven fabric, which was under a quasi-static load imposed by an impactor head. Due to the substantial radial strain in the fabric, the spectrums of different FBGs were found to overlap during the loading process. With the developed interrogating method, the overlapped spectrum would be distinguished thus the wavelength shift of each sensor can be monitored.

Profiling CPU-bound workloads on Intel Haswell-EP platforms

CERN Document Server

Guerri, Marco; Cristovao, Cordeiro; CERN. Geneva. IT Department

2017-01-01

With the increasing adoption of public and private cloud resources to support the demands in terms of computing capacity of the WLCG, the HEP community has begun studying several benchmarking applications aimed at continuously assessing the performance of virtual machines procured from commercial providers. In order to characterise the behaviour of these benchmarks, in-depth profiling activities have been carried out. In this document we outline our experience in profiling one specific application, the ATLAS Kit Validation, in an attempt to explain an unexpected distribution in the performance samples obtained on systems based on Intel Haswell-EP processors.

TEMPS-A[p] temperament profile related to professional choice: A study in 1548 applicants to become a cadet officer in the Italian air force.

Science.gov (United States)

Maremmani, Icro; Dell'Osso, Liliana; Rovai, Luca; Pacini, Matteo; Arduino, Gualberto; Montagnari, Antonio; Abbenante, Domenico; Maremmani, Angelo G I; Giulio, Perugi; Akiskal, Kareen; Akiskal, Hagop

2010-08-01

Temperaments have been described with respect to their adaptive roles. Thus, depressive traits seem to increase sensitivity to suffering, cyclothymic traits appear relevant to creativity, and hyperthymic traits have been implicated in territoriality and leadership and more generally in active pursuits. The temperaments of 1548 candidates applying to become a cadet officer in the Italian air force, who had taken the 2005 entrance examination, were compared with deviant and non-deviant peers. At a psychological level, we also compared those who had applied to become a cadet officer with other applicants who had failed in a previous entrance examination and with applicants who had passed or failed to pass the specific psychological entrance examination. Applicants who took the entrance examination are more hyperthymic than their peers, regardless of any concurrent psychosocial deviance (i.e. drug addiction). The specificity of this correlation is confirmed by the fact that applicants who made a second attempt to pass the entrance examination after an initial failure were more hyperthymic than first-time applicants. Similarly, success in specific psychological admission tests is related to the same temperamental profiles, since those who prove to be psychologically fit are more hyperthymic. The inverse relationship emerges from an examination of other temperamental scales, which are better represented in controls (non-applicants), or other applicants making their first attempt at admission, or those who were excluded due to psychological flaws. In the present study, extremely high scores on the hyperthymic scale combined with extremely low ones in the cyclothymic scale seem to correspond to the specific temperament profile and to the highest likelihood of success in those applying to become a cadet officer in the Italian air force. Copyright 2010 Elsevier B.V. All rights reserved.

Fluorine profiling after application of various anti-caries gels

International Nuclear Information System (INIS)

Zschau, H.E.; Plier, F.; Otto, G.; Wyrwich, C.; Treide, A.

1990-01-01

Two newly developed caries-preventing gels were tested together with Elmex on pre-school children over a time of 3 years. Proton-induced gamma-ray emission spectrometry (PIGE) was used to measure the fluorine profiles in milk teeth (incisors). In accordance with the clinical statement the results allow to produce a new anti-caries drug. (orig.)

On the use of magnetic buckets for ion beam profile tailoring

International Nuclear Information System (INIS)

MacGill, R. A.; Vizir, A.; Brown, I. G.

2000-01-01

Magnetic multipole plasma confinement geometries employing permanent magnet ''buckets'' are used extensively for a range of laboratory plasma applications. Among the several consequences for plasma confinement is the important result that the plasma can acquire a more-or-less flat density profile, which when embodied in an ion source, can also lead to a flat profile for the extracted ion beam. For many applications a uniform ion beam current density profile is quite advantageous, for example, for carrying out large-area ion implantation. There are, however, inherent limitations on the extent to which this approach to beam ''homogenization'' can be utilized, and even for a perfectly flat profile in the immediate postextraction region, the beam will evolve toward Gaussian as it propagates downstream. Here we describe the rare-earth permanent magnet bucket that we have incorporated into our broad-beam vacuum arc ion source, and its effect on the beam profile at the extractor and downstream. The experimental results are compared with a simple model for the beam profile evolution with axial distance. We find that the beam loses memory of its initially flat profile and relaxes to a more-or-less Gaussian shape in a relatively short axial distance ∼w/4θ, where w is the initial width of the flat beam profile and θ is the beamlet divergence half angle. (c) 2000 American Institute of Physics

A UML profile for code generation of component based distributed systems

International Nuclear Information System (INIS)

Chiozzi, G.; Karban, R.; Andolfato, L.; Tejeda, A.

2012-01-01

A consistent and unambiguous implementation of code generation (model to text transformation) from UML (must rely on a well defined UML (Unified Modelling Language) profile, customizing UML for a particular application domain. Such a profile must have a solid foundation in a formally correct ontology, formalizing the concepts and their relations in the specific domain, in order to avoid a maze or set of wildly created stereotypes. The paper describes a generic profile for the code generation of component based distributed systems for control applications, the process to distill the ontology and define the profile, and the strategy followed to implement the code generator. The main steps that take place iteratively include: defining the terms and relations with an ontology, mapping the ontology to the appropriate UML meta-classes, testing the profile by creating modelling examples, and generating the code. This has allowed us to work on the modelling of E-ELT (European Extremely Large Telescope) control system and instrumentation without knowing what infrastructure will be finally used

Background of SAM atom-fraction profiles

International Nuclear Information System (INIS)

Ernst, Frank

2017-01-01

Atom-fraction profiles acquired by SAM (scanning Auger microprobe) have important applications, e.g. in the context of alloy surface engineering by infusion of carbon or nitrogen through the alloy surface. However, such profiles often exhibit an artifact in form of a background with a level that anti-correlates with the local atom fraction. This article presents a theory explaining this phenomenon as a consequence of the way in which random noise in the spectrum propagates into the discretized differentiated spectrum that is used for quantification. The resulting model of “energy channel statistics” leads to a useful semi-quantitative background reduction procedure, which is validated by applying it to simulated data. Subsequently, the procedure is applied to an example of experimental SAM data. The analysis leads to conclusions regarding optimum experimental acquisition conditions. The proposed method of background reduction is based on general principles and should be useful for a broad variety of applications. - Highlights: • Atom-fraction–depth profiles of carbon measured by scanning Auger microprobe • Strong background, varies with local carbon concentration. • Needs correction e.g. for quantitative comparison with simulations • Quantitative theory explains background. • Provides background removal strategy and practical advice for acquisition

Background of SAM atom-fraction profiles

Energy Technology Data Exchange (ETDEWEB)

Ernst, Frank

2017-03-15

Atom-fraction profiles acquired by SAM (scanning Auger microprobe) have important applications, e.g. in the context of alloy surface engineering by infusion of carbon or nitrogen through the alloy surface. However, such profiles often exhibit an artifact in form of a background with a level that anti-correlates with the local atom fraction. This article presents a theory explaining this phenomenon as a consequence of the way in which random noise in the spectrum propagates into the discretized differentiated spectrum that is used for quantification. The resulting model of “energy channel statistics” leads to a useful semi-quantitative background reduction procedure, which is validated by applying it to simulated data. Subsequently, the procedure is applied to an example of experimental SAM data. The analysis leads to conclusions regarding optimum experimental acquisition conditions. The proposed method of background reduction is based on general principles and should be useful for a broad variety of applications. - Highlights: • Atom-fraction–depth profiles of carbon measured by scanning Auger microprobe • Strong background, varies with local carbon concentration. • Needs correction e.g. for quantitative comparison with simulations • Quantitative theory explains background. • Provides background removal strategy and practical advice for acquisition.

Metadata requirements for results of diagnostic imaging procedures: a BIIF profile to support user applications

Science.gov (United States)

Brown, Nicholas J.; Lloyd, David S.; Reynolds, Melvin I.; Plummer, David L.

2002-05-01

A visible digital image is rendered from a set of digital image data. Medical digital image data can be stored as either: (a) pre-rendered format, corresponding to a photographic print, or (b) un-rendered format, corresponding to a photographic negative. The appropriate image data storage format and associated header data (metadata) required by a user of the results of a diagnostic procedure recorded electronically depends on the task(s) to be performed. The DICOM standard provides a rich set of metadata that supports the needs of complex applications. Many end user applications, such as simple report text viewing and display of a selected image, are not so demanding and generic image formats such as JPEG are sometimes used. However, these are lacking some basic identification requirements. In this paper we make specific proposals for minimal extensions to generic image metadata of value in various domains, which enable safe use in the case of two simple healthcare end user scenarios: (a) viewing of text and a selected JPEG image activated by a hyperlink and (b) viewing of one or more JPEG images together with superimposed text and graphics annotation using a file specified by a profile of the ISO/IEC Basic Image Interchange Format (BIIF).

Optimizing laser beam profiles using micro-lens arrays for efficient material processing: applications to solar cells

Science.gov (United States)

Hauschild, Dirk; Homburg, Oliver; Mitra, Thomas; Ivanenko, Mikhail; Jarczynski, Manfred; Meinschien, Jens; Bayer, Andreas; Lissotschenko, Vitalij

2009-02-01

High power laser sources are used in various production tools for microelectronic products and solar cells, including the applications annealing, lithography, edge isolation as well as dicing and patterning. Besides the right choice of the laser source suitable high performance optics for generating the appropriate beam profile and intensity distribution are of high importance for the right processing speed, quality and yield. For industrial applications equally important is an adequate understanding of the physics of the light-matter interaction behind the process. In advance simulations of the tool performance can minimize technical and financial risk as well as lead times for prototyping and introduction into series production. LIMO has developed its own software founded on the Maxwell equations taking into account all important physical aspects of the laser based process: the light source, the beam shaping optical system and the light-matter interaction. Based on this knowledge together with a unique free-form micro-lens array production technology and patented micro-optics beam shaping designs a number of novel solar cell production tool sub-systems have been built. The basic functionalities, design principles and performance results are presented with a special emphasis on resilience, cost reduction and process reliability.

Application analysis tools for ASIP design: application profiling and instruction-set customization

National Research Council Canada - National Science Library

Karuri, Kingshuk; Leupers, Ranier

2011-01-01

... of the operating system they are targeting and execute them on the main application processor in the SmartPhone. However these are not the only applications that need to run on the SmartPhone. There are many underlying applications, or lets better call them algorithms, that have very demanding performance and power consumption targets, yet need to be flexible. Here is where the custom processor comes into play for the implementation of algorithms that will have certain variability but are covering a narrow enough design sp...

MEASURING DARK MATTER PROFILES NON-PARAMETRICALLY IN DWARF SPHEROIDALS: AN APPLICATION TO DRACO

International Nuclear Information System (INIS)

Jardel, John R.; Gebhardt, Karl; Fabricius, Maximilian H.; Williams, Michael J.; Drory, Niv

2013-01-01

We introduce a novel implementation of orbit-based (or Schwarzschild) modeling that allows dark matter density profiles to be calculated non-parametrically in nearby galaxies. Our models require no assumptions to be made about velocity anisotropy or the dark matter profile. The technique can be applied to any dispersion-supported stellar system, and we demonstrate its use by studying the Local Group dwarf spheroidal galaxy (dSph) Draco. We use existing kinematic data at larger radii and also present 12 new radial velocities within the central 13 pc obtained with the VIRUS-W integral field spectrograph on the 2.7 m telescope at McDonald Observatory. Our non-parametric Schwarzschild models find strong evidence that the dark matter profile in Draco is cuspy for 20 ≤ r ≤ 700 pc. The profile for r ≥ 20 pc is well fit by a power law with slope α = –1.0 ± 0.2, consistent with predictions from cold dark matter simulations. Our models confirm that, despite its low baryon content relative to other dSphs, Draco lives in a massive halo.

Application of Depth-Averaged Velocity Profile for Estimation of Longitudinal Dispersion in Rivers

Directory of Open Access Journals (Sweden)

Mohammad Givehchi

2010-01-01

Full Text Available River bed profiles and depth-averaged velocities are used as basic data in empirical and analytical equations for estimating the longitudinal dispersion coefficient which has always been a topic of great interest for researchers. The simple model proposed by Maghrebi is capable of predicting the normalized isovel contours in the cross section of rivers and channels as well as the depth-averaged velocity profiles. The required data in Maghrebi’s model are bed profile, shear stress, and roughness distributions. Comparison of depth-averaged velocities and longitudinal dispersion coefficients observed in the field data and those predicted by Maghrebi’s model revealed that Maghrebi’s model had an acceptable accuracy in predicting depth-averaged velocity.

The psychological selection profile for civil-military coordination ...

African Journals Online (AJOL)

from job incumbents to assess the relationship between performance and profile ... TO ASSESS APPLICANTS' ..... Knuth (1999) and Natsios (1995) characterised complex emergencies as a ..... Journal of Personality Assessment, 72 (3), pp.

ANALYSIS OF THE RESULTS OF PRESBYOPIA CORRECTION WITH APPLICATION OF A BI-ASPHERIC MULTIFOCAL PROFILE ON THE CORNEA BY THE PRK FOR PATIENTS WITH MYOPIA AND HYPEROPIA

Directory of Open Access Journals (Sweden)

E. N. Eskina

2017-01-01

Full Text Available Purpose. To compare the efficacy, safety and predictability of presbyopia correction by the PRK with application of a bi-aspheric multifocal profile on the cornea with PresbyMax software for patients with hyperopia and myopia.Patients and methods: There were 2 patients group of 25 people each (50 eyes. They were operated with PRK method with application of a multifocal biaspheric profile for simultaneous correction of ametropia and presbyopia. Group I — patients with myopia and presbyopia. Group II — patients with hypermetropia and presbyopia.Results. In the group 1 year post operation binocular DUCVA was 0,93±0,19, NUCVA — 0,86±0,14, IUCVA — 0,67±0,11. Only two eyes (4 % lost DBCVA on the 1–2 lines. Target refraction of a dominant eye — emmetropia was 72 % of patients, 28 % observed myopia of –0,75 D. Target refraction of a nondominant eye was –0,75, 68 % had this result, 28 % had deviation –0,50 D of the target refraction, and 4 % — 1,00 D. In group 2 a year post operation binocular DUCVA was 0,96±0,16, NUCVA — 0,77±0,19, IUCVA — 0,64±0,15. Only two eyes (4 % lost DBCVA on the 1–2 lines. Target refraction of a dominant eye — emmetropia was 72 % of patients, 28 % observed myopia of –0,75 D. Target refraction of a nondominant eye was –0,75, 68 % had this result, 32 % had deviation to –0,75 D of the target refraction.Conclusions. PRK with application of a bi-aspheric multifocal profile on the cornea using PresbyMAX software and µ-monovision is effective for correction myopia and hypermetropia. Simultaneous correction of ametropia and presbyopia by the PRK method with the application of the multifocal biospheric profile to the cornea with the formation of a slight anisometropia (the concept of µ-monovision with the PresbyMax software is an effective, safe and predictable method of surgical intervention, both in myopia and hypermetropia.

Mission Profile Based Sizing of IGBT Chip Area for PV Inverter Applications

DEFF Research Database (Denmark)

Shen, Yanfeng; Wang, Huai; Yang, Yongheng

2016-01-01

Maximizing the total energy generation is of importance for Photovoltaic (PV) plants. This paper proposes a method to optimize the IGBT chip area for PV inverters to minimize the annual energy loss of the active switches based on long-term operation conditions (i.e., mission profile). The design...... yearly mission profile. Simulation results are given to verify the thermal characteristics. Furthermore, a Monte Carlo based lifetime evaluation is presented to check the IGBT reliability. The proposed design method enables a reliability-oriented energy optimized sizing of active switches for PV inverter...

Community-aware user profile enrichment in folksonomy.

Science.gov (United States)

Xie, Haoran; Li, Qing; Mao, Xudong; Li, Xiaodong; Cai, Yi; Rao, Yanghui

2014-10-01

In the era of big data, collaborative tagging (a.k.a. folksonomy) systems have proliferated as a consequence of the growth of Web 2.0 communities. Constructing user profiles from folksonomy systems is useful for many applications such as personalized search and recommender systems. The identification of latent user communities is one way to better understand and meet user needs. The behavior of users is highly influenced by the behavior of their neighbors or community members, and this can be utilized in constructing user profiles. However, conventional user profiling techniques often encounter data sparsity problems as data from a single user is insufficient to build a powerful profile. Hence, in this paper we propose a method of enriching user profiles based on latent user communities in folksonomy data. Specifically, the proposed approach contains four sub-processes: (i) tag-based user profiles are extracted from a folksonomy tripartite graph; (ii) a multi-faceted folksonomy graph is constructed by integrating tag and image affinity subgraphs with the folksonomy tripartite graph; (iii) random walk distance is used to unify various relationships and measure user similarities; (iv) a novel prototype-based clustering method based on user similarities is used to identify user communities, which are further used to enrich the extracted user profiles. To evaluate the proposed method, we conducted experiments using a public dataset, the results of which show that our approach outperforms previous ones in user profile enrichment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Comparison of RASS temperature profiles with other tropospheric soundings

International Nuclear Information System (INIS)

Bonino, G.; Lombardini, P.P.; Trivero, P.

1980-01-01

The vertical temperature profile of the lower troposphere can be measured with a radio-acoustic sounding system (RASS). A comparison of the thermal profiles measured with the RASS and with traditional methods shows a) RASS ability to produce vertical thermal profiles at an altitude range of 170 to 1000 m with temperature accuracy and height discrimination comparable with conventional soundings, b) advantages of remote sensing as offered by new sounder, c) applicability of RASS both in assessing evolution of thermodynamic conditions in PBL and in sensing conditions conducive to high concentrations of air pollutants at the ground level. (author)

Will it Ever be Possible to Profile the Terrorist?

Directory of Open Access Journals (Sweden)

Jonathan A Rae

2012-09-01

Full Text Available 'This paper critiques the claim that terrorists can be profiled – that is to say that terrorists possess distinguishable attributes that can be conceivably identified by an observer. In doing so, the most prominent profiling parameters - racial, gender, age, pathological, psychological and socioeconomic – are investigated. The above approaches are found to have little to no applied value in identifying terrorists from a societal population. The dominant criticisms of these methods emphasise their crude reductionism, an absence of internal and external validity, and their lack of practical application. Current evidence indicates that the profiling of terrorists is a futile venture.'

Ion induced optical emission for surface and depth profile analysis

International Nuclear Information System (INIS)

White, C.W.

1977-01-01

Low-energy ion bombardment of solid surfaces results in the emission of infrared, visible, and ultraviolet radiation produced by inelastic ion-solid collision processes. The emitted optical radiation provides important insight into low-energy particle-solid interactions and provides the basis for an analysis technique which can be used for surface and depth profile analysis with high sensitivity. The different kinds of collision induced optical radiation emitted as a result of low-energy particle-solid collisions are reviewed. Line radiation arising from excited states of sputtered atoms or molecules is shown to provide the basis for surface and depth profile analysis. The spectral characteristics of this type of radiation are discussed and applications of the ion induced optical emission technique are presented. These applications include measurements of ion implant profiles, detection sensitivities for submonolayer quantities of impurities on elemental surfaces, and the detection of elemental impurities on complex organic substrates

Detecting and classifying method based on similarity matching of Android malware behavior with profile.

Science.gov (United States)

Jang, Jae-Wook; Yun, Jaesung; Mohaisen, Aziz; Woo, Jiyoung; Kim, Huy Kang

2016-01-01

Mass-market mobile security threats have increased recently due to the growth of mobile technologies and the popularity of mobile devices. Accordingly, techniques have been introduced for identifying, classifying, and defending against mobile threats utilizing static, dynamic, on-device, and off-device techniques. Static techniques are easy to evade, while dynamic techniques are expensive. On-device techniques are evasion, while off-device techniques need being always online. To address some of those shortcomings, we introduce Andro-profiler, a hybrid behavior based analysis and classification system for mobile malware. Andro-profiler main goals are efficiency, scalability, and accuracy. For that, Andro-profiler classifies malware by exploiting the behavior profiling extracted from the integrated system logs including system calls. Andro-profiler executes a malicious application on an emulator in order to generate the integrated system logs, and creates human-readable behavior profiles by analyzing the integrated system logs. By comparing the behavior profile of malicious application with representative behavior profile for each malware family using a weighted similarity matching technique, Andro-profiler detects and classifies it into malware families. The experiment results demonstrate that Andro-profiler is scalable, performs well in detecting and classifying malware with accuracy greater than 98 %, outperforms the existing state-of-the-art work, and is capable of identifying 0-day mobile malware samples.

Compton profile with synchrotron light - application to Y-123 superconductivity

International Nuclear Information System (INIS)

De, Udayan

2005-01-01

Electron beam accelerated to 6 GeV in the European Synchrotron Radiation Facility (ESRF) at Grenoble, France, can deliver highly mono-energetic, intense (10 12 photons/sec at sample at 100 mA ring current) and fine photon beam reaching x-ray and γ energies. So photons of 57 keV from this synchrotron has been used for Compton Profile or CP experiment (at different temperatures down to 70 K) on our YBa 2 Cu 3 O 7 or Y-123 single crystals with T c = 91 K. Photons, Compton scattered even at a definite angle, θ, show a distribution (called Compton Profile) of energy and hence of momentum reflecting the EMD or electron momentum distribution in the solid. The temperature variation of S-parameter, defined as the fraction of low momentum electrons, has been found from preliminary CP data. It confirmed the surprising double minimum found from Doppler broadening of positron annihilation radiation lineshape (DBPARL). The CP set-up at the synchrotron including the detectors and cryogenics as well as the new results are outlined. (author)

Depth profiling of helium in Ni and Nb; comparison of different methods

International Nuclear Information System (INIS)

Scherzer, B.M.U.; Bay, H.L.; Behrisch, R.; Boergesen, P.; Roth, J.

1978-01-01

Depth profiles of 30 keV 3 He + and 4 He + implanted in polycrystalline nickel and single crystal niobium have been measured using the nuclear reactions He(p,p)He and 3 He(d,α) 1 H. The formalism for obtaining depth profiles from Rutherford backscattering spectra has been generalized for the application to nuclear reaction spectra. The profiles obtained by the two different methods agree within the errors introduced by the uncertainties of the reaction cross-section and electronic stopping power data. The 3 He(d,α) 1 H method is a factor of 10-100 more sensitive and has about a factor of 5 better depth resolution than the He(p,p)He method. However, the latter method allows to probe much larger depths and is simultaneously applicable to 4 He as well as to 3 He. Within the experimental uncertainties the depth profiles for 3 He and 4 He are identical. (Auth.)

Low-Profile Multiband and Flush-Mountable Wideband Antennas for HF/VHF and K/Ka Band Applications

Science.gov (United States)

Garrido Lopez, David

This thesis introduces several novel antenna systems with extended performance capabilities achieved by either enabling multiple operation bands or by widening the bandwidth. Proposed theoretical concepts are successfully tested through simulations and experiments with excellent agreement are demonstrated. The designs developed in this thesis research are low-profile or flush mountable, enabling simple platform integration. In the HF/VHF bands, the development of a novel low-profile multiband antenna for vehicular applications is presented. Specifically, an inverted-F antenna is used as a driven element, to operate at the lowest frequency of 27 MHz, whereas two parasitic elements are built as inverted-L monopoles to enable resonances at 49 and 53 MHz. To eliminate the need for an external matching network, an offset feeding technique is used. When the antenna is mounted on a vehicle and bent to follow its profile, a very low-profile is achieved (lambda/44) while good impedance and far-field performance are maintained across all three bands. The developed antenna system is not only electrically smallest among others found in the literature, but it is easily modified for other band selections and tuning of each band can be readily achieved. Vehicular antennas are often used for high power applications, which may cause exposure of nearby individuals to possibly dangerous electromagnetic fields. To assess this hazard, the RF exposure of a vehicle's crew is discussed and an original and fast modeling approach for prediction thereof is demonstrated. The modeling approach is based on eigenmode analysis for acquiring a range of frequencies where the shielding effectiveness of a vehicle cabin is expected to be lower than average. This approach is typically much faster and requires less computational resources as compared to classical full-wave analyses. This analysis also shows that the position of an antenna system is critical and must be considered when high-power RF

Freedom of expression: cell-type-specific gene profiling.

Science.gov (United States)

Otsuki, Leo; Cheetham, Seth W; Brand, Andrea H

2014-01-01

Cell fate and behavior are results of differential gene regulation, making techniques to profile gene expression in specific cell types highly desirable. Many methods now enable investigation at the DNA, RNA and protein level. This review introduces the most recent and popular techniques, and discusses key issues influencing the choice between these such as ease, cost and applicability of information gained. Interdisciplinary collaborations will no doubt contribute further advances, including not just in single cell type but single-cell expression profiling. © 2014 Wiley Periodicals, Inc.

An approach for risk management and regulatory applications

International Nuclear Information System (INIS)

Wong, See-Meng

2000-01-01

This paper discusses the development and potential applications of a PRA methodology for risk management and regulatory applications in the U.S. nuclear industry. The new PRA methodology centers on the development of time-dependent configuration risk profiles for evaluating the effectiveness of operational risk management programs at U.S. nuclear power plants. Configuration-risk profiles have been used as risk-information tools for (1) a better understanding of the impact of daily operational activities on plant safety and (2) proactive planning of operational activities to manage risk. Trial applications of the methodology were undertaken to demonstrate that configuration-risk profiles can be developed routinely, and can be useful for various industry and regulatory applications. Lessons learned include a better understanding of the issues and characteristics of PRA models available to industry, and identifying the attributes and pitfalls in the development of risk profiles. (author)

Machine Learing Applications on a Radar Wind Profiler Deployment During the ARM GoAmazon2014/5 Campaign

Science.gov (United States)

Giangrande, S. E.; WANG, D.; Hardin, J. C.; Mitchell, J.

2017-12-01

As part of the 2 year Department of Energy Atmospheric Radiation Measurement (ARM) Observations and Modeling of the Green Ocean Amazon (GoAmazon2014/5) campaign, the ARM Mobile Facility (AMF) collected a unique set of observations in a region of strong climatic significance near Manacapuru, Brazil. An important example for the beneficial observational record obtained by ARM during this campaign was that of the Radar Wind Profiler (RWP). This dataset has been previously documented for providing critical convective cloud vertical air velocity retrievals and precipitation properties (e.g., calibrated reflectivity factor Z, rainfall rates) under a wide variety of atmospheric conditions. Vertical air motion estimates to within deep convective cores such as those available from this RWP system have been previously identified as critical constraints for ongoing global climate modeling activities and deep convective cloud process studies. As an extended deployment within this `green ocean' region, the RWP site and collocated AMF surface gauge instrumentation experienced a unique hybrid of tropical and continental precipitation conditions, including multiple wet and dry season precipitation regimes, convective and organized stratiform storm dynamics and contributions to rainfall accumulation, pristine aerosol conditions of the locale, as well as the effects of the Manaus, Brazil, mega city pollution plume. For hydrological applications and potential ARM products, machine learning methods developed using this dataset are explored to demonstrate advantages in geophysical retrievals when compared to traditional methods. Emphasis is on performance improvements when providing additional information on storm structure and regime or echo type classifications. Since deep convective cloud dynamic insights (core updraft/downdraft properties) are difficult to obtain directly by conventional radars that also observe radar reflectivity factor profiles similar to RWP systems, we also

An Analytical Method for the Abel Inversion of Asymmetrical Gaussian Profiles

International Nuclear Information System (INIS)

Xu Guosheng; Wan Baonian

2007-01-01

An analytical algorithm for fast calculation of the Abel inversion for density profile measurement in tokamak is developed. Based upon the assumptions that the particle source is negligibly small in the plasma core region, density profiles can be approximated by an asymmetrical Gaussian distribution controlled only by one parameter V 0 /D and V 0 /D is constant along the radial direction, the analytical algorithm is presented and examined against a testing profile. The validity is confirmed by benchmark with the standard Abel inversion method and the theoretical profile. The scope of application as well as the error analysis is also discussed in detail

Meta-analysis methods for combining multiple expression profiles: comparisons, statistical characterization and an application guideline.

Science.gov (United States)

Chang, Lun-Ching; Lin, Hui-Min; Sibille, Etienne; Tseng, George C

2013-12-21

As high-throughput genomic technologies become accurate and affordable, an increasing number of data sets have been accumulated in the public domain and genomic information integration and meta-analysis have become routine in biomedical research. In this paper, we focus on microarray meta-analysis, where multiple microarray studies with relevant biological hypotheses are combined in order to improve candidate marker detection. Many methods have been developed and applied in the literature, but their performance and properties have only been minimally investigated. There is currently no clear conclusion or guideline as to the proper choice of a meta-analysis method given an application; the decision essentially requires both statistical and biological considerations. We performed 12 microarray meta-analysis methods for combining multiple simulated expression profiles, and such methods can be categorized for different hypothesis setting purposes: (1) HS(A): DE genes with non-zero effect sizes in all studies, (2) HS(B): DE genes with non-zero effect sizes in one or more studies and (3) HS(r): DE gene with non-zero effect in "majority" of studies. We then performed a comprehensive comparative analysis through six large-scale real applications using four quantitative statistical evaluation criteria: detection capability, biological association, stability and robustness. We elucidated hypothesis settings behind the methods and further apply multi-dimensional scaling (MDS) and an entropy measure to characterize the meta-analysis methods and data structure, respectively. The aggregated results from the simulation study categorized the 12 methods into three hypothesis settings (HS(A), HS(B), and HS(r)). Evaluation in real data and results from MDS and entropy analyses provided an insightful and practical guideline to the choice of the most suitable method in a given application. All source files for simulation and real data are available on the author's publication website.

Sensitivity of the urban airshed model to mixing height profiles

Energy Technology Data Exchange (ETDEWEB)

Rao, S.T.; Sistla, G.; Ku, J.Y.; Zhou, N.; Hao, W. [New York State Dept. of Environmental Conservation, Albany, NY (United States)

1994-12-31

The United States Environmental Protection Agency (USEPA) has recommended the use of the Urban Airshed Model (UAM), a grid-based photochemical model, for regulatory applications. One of the important parameters in applications of the UAM is the height of the mixed layer or the diffusion break. In this study, we examine the sensitivity of the UAM-predicted ozone concentrations to (a) a spatially invariant diurnal mixing height profile, and (b) a spatially varying diurnal mixing height profile for a high ozone episode of July 1988 for the New York Airshed. The 1985/88 emissions inventory used in the EPA`s Regional Oxidant Modeling simulations has been regridded for this study. Preliminary results suggest that the spatially varying case yields a higher peak ozone concentrations compared to the spatially invariant mixing height simulation, with differences in the peak ozone ranging from a few ppb to about 40 ppb for the days simulated. These differences are attributed to the differences in the shape of the mixing height profiles and its rate of growth during the morning hours when peak emissions are injected into the atmosphere. Examination of the impact of emissions reductions associated with these two mixing height profiles indicates that NO{sub x}-focussed controls provide a greater change in the predicted ozone peak under spatially invariant mixing heights than under the spatially varying mixing height profile. On the other hand, VOC-focussed controls provide a greater change in the predicted peak ozone levels under spatially varying mixing heights than under the spatially invariant mixing height profile.

Bioorthogonal chemistry: applications in activity-based protein profiling.

Science.gov (United States)

Willems, Lianne I; van der Linden, Wouter A; Li, Nan; Li, Kah-Yee; Liu, Nora; Hoogendoorn, Sascha; van der Marel, Gijs A; Florea, Bogdan I; Overkleeft, Herman S

2011-09-20

of chemical biology research include contributions from many areas of the multifaceted discipline of chemistry, and particularly from organic chemistry. Researchers apply knowledge inherent to organic chemistry, such as reactivity and selectivity, to the manipulation of specific biomolecules in biological samples (cell extracts, living cells, and sometimes even animal models) to gain insight into the biological phenomena in which these molecules participate. In this Account, we highlight some of the recent developments in chemical biology research driven by organic chemistry, with a focus on bioorthogonal chemistry in relation to activity-based protein profiling. The rigorous demands of bioorthogonality have not yet been realized in a truly bioorthogonal reagent pair, but remarkable progress has afforded a range of tangible contributions to chemical biology research. Activity-based protein profiling, which aims to obtain information on the workings of a protein (or protein family) within the larger context of the full biological system, has in particular benefited from these advances. Both activity-based protein profiling and bioorthogonal chemistry have been around for approximately 15 years, and about 8 years ago the two fields very profitably intersected. We expect that each discipline, both separately and in concert, will continue to make important contributions to chemical biology research. © 2011 American Chemical Society

PIXE depth profiling using variation of detection angle

International Nuclear Information System (INIS)

Miranda, J.; Rickards, J.; Trejo-Luna, R.

2006-01-01

A method to apply particle induced X-ray emission (PIXE) for depth profiling, based on the variation of the X-ray detection angle, is proposed. The procedure uses X-ray yields normalized to those emitted at a particular reference angle. Application of the method to implanted samples and thin metallic films gave excellent results regarding the range of implanted ions and film thickness, respectively. However, there is no complete information about the width of the distribution of the implanted ions, emphasizing the need to develop a full mathematical algorithm to obtain the general depth profile

Methods and Tools for Profiling and Control of Distributed Systems

Directory of Open Access Journals (Sweden)

Sukharev Roman

2017-01-01

Full Text Available The article analyzes and standardizes methods for profiling distributed systems that focus on simulation to conduct experiments and build a graph model of the system. The theory of queueing networks is used for simulation modeling of distributed systems, receiving and processing user requests. To automate the above method of profiling distributed systems the software application was developed with a modular structure and similar to a SCADA-system.

User Profile Analysis Using an Online Social Network Integrated Quiz Game

Directory of Open Access Journals (Sweden)

Yusuf YASLAN

2017-09-01

Full Text Available User interest profiling is important for personalized web search, recommendation and retrieval systems. In order to develop a good personalized application one needs to have accurate representation of user profiles. Most of the personalized systems generate interest profiles from user declarations or inferred from cookies or visited web pages. But to achieve a certain result that satisfies the user needs, explicit definition of the user interests is needed. In this paper we propose to obtain interest profiles from a quiz game played by the user where at each play he/she is asked 10 questions from different categories with different difficulty levels. The developed quiz game is integrated to Facebook online social network. By doing so, we had the chance to extract each user’s both explicit Facebook interest profiles and implicit interest profiles from quiz game answers. These profiles are used to extract different features for each user. Both implicit interest profile and explicit interest profile features are evaluated for clustering and interest ranking tasks separately. The experimental results show that the implicit interest profile features have promising results on personalized systems.

Phylo_dCor: distance correlation as a novel metric for phylogenetic profiling.

Science.gov (United States)

Sferra, Gabriella; Fratini, Federica; Ponzi, Marta; Pizzi, Elisabetta

2017-09-05

Elaboration of powerful methods to predict functional and/or physical protein-protein interactions from genome sequence is one of the main tasks in the post-genomic era. Phylogenetic profiling allows the prediction of protein-protein interactions at a whole genome level in both Prokaryotes and Eukaryotes. For this reason it is considered one of the most promising methods. Here, we propose an improvement of phylogenetic profiling that enables handling of large genomic datasets and infer global protein-protein interactions. This method uses the distance correlation as a new measure of phylogenetic profile similarity. We constructed robust reference sets and developed Phylo-dCor, a parallelized version of the algorithm for calculating the distance correlation that makes it applicable to large genomic data. Using Saccharomyces cerevisiae and Escherichia coli genome datasets, we showed that Phylo-dCor outperforms phylogenetic profiling methods previously described based on the mutual information and Pearson's correlation as measures of profile similarity. In this work, we constructed and assessed robust reference sets and propose the distance correlation as a measure for comparing phylogenetic profiles. To make it applicable to large genomic data, we developed Phylo-dCor, a parallelized version of the algorithm for calculating the distance correlation. Two R scripts that can be run on a wide range of machines are available upon request.

Numerical code for fitting radial emission profile of a shell supernova remnant: Application

Directory of Open Access Journals (Sweden)

Opsenica Slobodan

2011-01-01

Full Text Available We present IDL (Interactive Data Language codes for fitting a theoretical emission profile of a shell supernova remnant (SNR to the mean profile of an SNR obtained from radio observations. Two considered theoretical models are: 1 a shell with constant emissivity and 2 a synchrotron shell with radially aligned magnetic field. The codes were applied to several observed supernova remnants. Good results are obtained in five considered cases, which justify the use of our code for remnants that are bright (so that observational errors are not large and spherically symmetric enough.

SnopViz, an interactive snow profile visualization tool

Science.gov (United States)

Fierz, Charles; Egger, Thomas; gerber, Matthias; Bavay, Mathias; Techel, Frank

2016-04-01

SnopViz is a visualization tool for both simulation outputs of the snow-cover model SNOWPACK and observed snow profiles. It has been designed to fulfil the needs of operational services (Swiss Avalanche Warning Service, Avalanche Canada) as well as offer the flexibility required to satisfy the specific needs of researchers. This JavaScript application runs on any modern browser and does not require an active Internet connection. The open source code is available for download from models.slf.ch where examples can also be run. Both the SnopViz library and the SnopViz User Interface will become a full replacement of the current research visualization tool SN_GUI for SNOWPACK. The SnopViz library is a stand-alone application that parses the provided input files, for example, a single snow profile (CAAML file format) or multiple snow profiles as output by SNOWPACK (PRO file format). A plugin architecture allows for handling JSON objects (JavaScript Object Notation) as well and plugins for other file formats may be added easily. The outputs are provided either as vector graphics (SVG) or JSON objects. The SnopViz User Interface (UI) is a browser based stand-alone interface. It runs in every modern browser, including IE, and allows user interaction with the graphs. SVG, the XML based standard for vector graphics, was chosen because of its easy interaction with JS and a good software support (Adobe Illustrator, Inkscape) to manipulate graphs outside SnopViz for publication purposes. SnopViz provides new visualization for SNOWPACK timeline output as well as time series input and output. The actual output format for SNOWPACK timelines was retained while time series are read from SMET files, a file format used in conjunction with the open source data handling code MeteoIO. Finally, SnopViz is able to render single snow profiles, either observed or modelled, that are provided as CAAML-file. This file format (caaml.org/Schemas/V5.0/Profiles/SnowProfileIACS) is an international

A new method for depth profiling

International Nuclear Information System (INIS)

Chittleborough, C.W.; Chaudhri, M.A.; Rouse, J.L.

1978-01-01

A simple method for obtaining depth profiles of concentrations has been developed for charged particle induced nuclear reactions which produce γ-rays or neutrons. This method is particularly suitable for non-resonant reactions but is also applicable to resonant reactions and can examine the concentration of the sought nuclide throughout the entire activation depth of the incoming particles in the matrix

Measurement of mobility profile in ion-implanted silicon layers using electroreflection spectroscopy

International Nuclear Information System (INIS)

Galiev, G.B.; Kapaev, V.V.; Mokerov, V.G.

1986-01-01

The possibility is shown of the application of the low field linearized electroreflection spectroscopy for the measurement of profiles of carriers mobilities μ(x) simultaneously with the concentration profiles N(x) in thin ion-implanted silicon layers. The μ(χ) value is determined from the calibration curve of the dependence of the phenomenological broadening parameter γ on the mobility for uniformly doped samples. The results are presented for the measurements of the profiles μ(x) for boron- and arsenic-implanted silicon

Evaluation of diffusion coefficients from composition profiles - the influence of trapping

DEFF Research Database (Denmark)

Christiansen, Thomas; Somers, Marcel A. J.

2006-01-01

The applicability of the Boltzmann-Matano method for evaluation of a diffusion coefficient and its concentration dependency by line profile analysis is tested on three different (model) systems. All systems involve interstitial diffusion. It is shown that the occurrence of trapping corrupts...... the applicability of the Boltzmann-Matano method....

The Impact of Mission Profile Models on the Predicted Lifetime of IGBT Modules in the Modular Multilevel Converter

DEFF Research Database (Denmark)

Zhang, Yi; Wang, Huai; Wang, Zhongxu

2017-01-01

and electrical power modeling methods on the estimated lifetime of IGBT modules in an MMC for offshore wind power application. In a 30 MW MMC case study, an annual wind speed profile with a resolution of 1 s/data, 10 minute/data, and 1 hour/data are considered, respectively. A method to re-generate higher......The reliability aspect study of Modular Multilevel Converter (MMC) is of great interest in industry applications, such as offshore wind. Lifetime prediction of key components is an important tool to design MMC with fulfilled reliability specifications. While many efforts have been made...... to the lifetime prediction of IGBT modules in renewable energy applications by considering long-term varying operation conditions (i.e., mission profile), the justifications of using the associated mission profiles are still missed. This paper investigates the impact of mission profile data resolutions...

Response of maize varieties to nitrogen application for leaf area profile, crop growth, yield and yield components

International Nuclear Information System (INIS)

Akmal, M.; Hameed-urRehman; Farhatullah; Asim, M.; Akbar, H.

2010-01-01

An experiment was conducted at NWFP Agricultural University, Peshawar, to study maize varieties and Nitrogen (N) rates for growth, yield and yield components. Three varieties (Azam, Jalal and Sarhad white) and three N rates (90, 120, 150, kg N ha/sup -1/) were compared. Experiment was conducted in a Randomized Complete Block design; split plot arrangement with 4 replications. Uniform and recommended cultural practices were applied during the crop growth. The results revealed that maize variety 'Jalal' performed relatively better crop growth rate (CGR) and leaf area profile (LAP) at nodal position one to six as compared to the other two varieties (Sarhad white and Azam). This resulted higher radiation use efficiency by the crop canopy at vegetative stage of development and hence contributed higher assimilates towards biomass production. Heavier grains in number and weight were due to higher LAP and taller plants of Jalal which yielded higher in the climate. Nitrogen applications have shown that maize seed yield increase in quadratic fashion with increased N to a plateau level. Considering soil fertility status and cropping system, the 150 kg ha/sup -1/ N application to maize variety Jalal in Peshawar is required for maximum biological and seed production. (author)

Computed tomographic reconstruction of beam profiles with a multi-wire chamber

International Nuclear Information System (INIS)

Alonso, J.R.; Tobias, C.A.; Chu, W.T.

1979-03-01

MEDUSA (MEdical Dose Uniformity SAmpler), a 16 plane multi-wire proportional chamber, has been built to accurately measure beam profiles. The large number of planes allows for reconstruction of highly detailed beam intensity structures by means of Fourier convolution reconstruction techniques. This instrument is being used for verification and tuning of the Bevalac radiotherapy beams, but has potential applications in many beam profile monitoring situations

Engineering Adaptive Web Applications

DEFF Research Database (Denmark)

Dolog, Peter

2007-01-01

suit the user profile the most. This paper summarizes the domain engineering framework for such adaptive web applications. The framework provides guidelines to develop adaptive web applications as members of a family. It suggests how to utilize the design artifacts as knowledge which can be used......Information and services on the web are accessible for everyone. Users of the web differ in their background, culture, political and social environment, interests and so on. Ambient intelligence was envisioned as a concept for systems which are able to adapt to user actions and needs....... With the growing amount of information and services, the web applications become natural candidates to adopt the concepts of ambient intelligence. Such applications can deal with divers user intentions and actions based on the user profile and can suggest the combination of information content and services which...

Application of Electromagnetic Induction to Monitor Changes in Soil Electrical Conductivity Profiles in Arid Agriculture

KAUST Repository

Jadoon, K.Z.

2015-09-06

In this research, multi-configuration electromagnetic induction (EMI) measurements were conducted in a corn field to estimate variation in soil electrical conductivity profiles in the roots zone. Electromagnetic forward model based on the full solution of Maxwell\\'s equation was used to simulate the apparent electrical conductivity measured with EMI system (the CMD mini-Explorer). Joint inversion of multi-configuration EMI measurements were performed to estimate the vertical soil electrical conductivity profiles. The inversion minimizes the misfit between the measured and modeled soil apparent electrical conductivity by DiffeRential Evolution Adaptive Metropolis (DREAM) algorithm, which is based on Bayesain approach. Results indicate that soil electrical conductivity profiles have low values close to the corn plants, which indicates loss of soil moisture due to the root water uptake. These results offer valuable insights into future potential and emerging challenges in the development of joint analysis of multi-configuration EMI measurements to retrieve effective soil electrical conductivity profiles.

A lifetime prediction method for LEDs considering mission profiles

DEFF Research Database (Denmark)

Qu, Xiaohui; Wang, Huai; Zhan, Xiaoqing

2016-01-01

and to benchmark the cost-competitiveness of different lighting technologies. The existing lifetime data released by LED manufacturers or standard organizations are usually applicable only for specific temperature and current levels. Significant lifetime discrepancies may be observed in field operations due...... to the varying operational and environmental conditions during the entire service time (i.e., mission profiles). To overcome the challenge, this paper proposes an advanced lifetime prediction method, which takes into account the field operation mission profiles and the statistical properties of the life data...

Real-time evaluation of electron and current density profile parameters on TEXTOR

International Nuclear Information System (INIS)

Bruessau, W.D.; Soltwisch, H.

1985-08-01

The shapes of electron and current density profiles are monitored in real-time mode in order to get rapid qualitative information on the development of a TEXTOR tokamak plasma. The profiles are described by form parameters which relate to the signals of a 9-channel FIR-polari/interferometer in simple mathematical formulae. These profile parameters are obtained by real-time conversion of measured quantities for display on a storage oscilloscope or on a chart recorder. The application of the parameters is demonstrated in some examples. (orig.)

Radio-guided sentinel lymph node identification by lymphoscintigraphy fused with an anatomical vector profile: clinical applications.

Science.gov (United States)

Niccoli Asabella, A; Antonica, F; Renna, M A; Rubini, D; Notaristefano, A; Nicoletti, A; Rubini, G

2013-12-01

To develop a method to fuse lymphoscintigraphic images with an adaptable anatomical vector profile and to evaluate its role in the clinical practice. We used Adobe Illustrator CS6 to create different vector profiles, we fused those profiles, using Adobe Photoshop CS6, with lymphoscintigraphic images of the patient. We processed 197 lymphoscintigraphies performed in patients with cutaneous melanomas, breast cancer or delayed lymph drainage. Our models can be adapted to every patient attitude or position and contain different levels of anatomical details ranging from external body profiles to the internal anatomical structures like bones, muscles, vessels, and lymph nodes. If needed, more new anatomical details can be added and embedded in the profile without redrawing them, saving a lot of time. Details can also be easily hidden, allowing the physician to view only relevant information and structures. Fusion times are about 85 s. The diagnostic confidence of the observers increased significantly. The validation process showed a slight shift (mean 4.9 mm). We have created a new, practical, inexpensive digital technique based on commercial software for fusing lymphoscintigraphic images with built-in anatomical reference profiles. It is easily reproducible and does not alter the original scintigraphic image. Our method allows a more meaningful interpretation of lymphoscintigraphies, an easier recognition of the anatomical site and better lymph node dissection planning.

Design for ASIC reliability for low-temperature applications

Science.gov (United States)

Chen, Yuan; Mojaradi, Mohammad; Westergard, Lynett; Billman, Curtis; Cozy, Scott; Burke, Gary; Kolawa, Elizabeth

2005-01-01

In this paper, we present a methodology to design for reliability for low temperature applications without requiring process improvement. The developed hot carrier aging lifetime projection model takes into account both the transistor substrate current profile and temperature profile to determine the minimum transistor size needed in order to meet reliability requirements. The methodology is applicable for automotive, military, and space applications, where there can be varying temperature ranges. A case study utilizing this methodology is given to design for reliability into a custom application-specific integrated circuit (ASIC) for a Mars exploration mission.

Reading Profiles in Multi-Site Data With Missingness.

Science.gov (United States)

Eckert, Mark A; Vaden, Kenneth I; Gebregziabher, Mulugeta

2018-01-01

Children with reading disability exhibit varied deficits in reading and cognitive abilities that contribute to their reading comprehension problems. Some children exhibit primary deficits in phonological processing, while others can exhibit deficits in oral language and executive functions that affect comprehension. This behavioral heterogeneity is problematic when missing data prevent the characterization of different reading profiles, which often occurs in retrospective data sharing initiatives without coordinated data collection. Here we show that reading profiles can be reliably identified based on Random Forest classification of incomplete behavioral datasets, after the missForest method is used to multiply impute missing values. Results from simulation analyses showed that reading profiles could be accurately classified across degrees of missingness (e.g., ∼5% classification error for 30% missingness across the sample). The application of missForest to a real multi-site dataset with missingness ( n = 924) showed that reading disability profiles significantly and consistently differed in reading and cognitive abilities for cases with and without missing data. The results of validation analyses indicated that the reading profiles (cases with and without missing data) exhibited significant differences for an independent set of behavioral variables that were not used to classify reading profiles. Together, the results show how multiple imputation can be applied to the classification of cases with missing data and can increase the integrity of results from multi-site open access datasets.

Reading Profiles in Multi-Site Data With Missingness

Directory of Open Access Journals (Sweden)

Mark A. Eckert

2018-05-01

Full Text Available Children with reading disability exhibit varied deficits in reading and cognitive abilities that contribute to their reading comprehension problems. Some children exhibit primary deficits in phonological processing, while others can exhibit deficits in oral language and executive functions that affect comprehension. This behavioral heterogeneity is problematic when missing data prevent the characterization of different reading profiles, which often occurs in retrospective data sharing initiatives without coordinated data collection. Here we show that reading profiles can be reliably identified based on Random Forest classification of incomplete behavioral datasets, after the missForest method is used to multiply impute missing values. Results from simulation analyses showed that reading profiles could be accurately classified across degrees of missingness (e.g., ∼5% classification error for 30% missingness across the sample. The application of missForest to a real multi-site dataset with missingness (n = 924 showed that reading disability profiles significantly and consistently differed in reading and cognitive abilities for cases with and without missing data. The results of validation analyses indicated that the reading profiles (cases with and without missing data exhibited significant differences for an independent set of behavioral variables that were not used to classify reading profiles. Together, the results show how multiple imputation can be applied to the classification of cases with missing data and can increase the integrity of results from multi-site open access datasets.

Acoustic Doppler current profiler applications used in rivers and estuaries by the U.S. Geological Survey

Science.gov (United States)

Gotvald, Anthony J.; Oberg, Kevin A.

2009-01-01

The U.S. Geological Survey (USGS) has collected streamflow information for the Nation's streams since 1889. Streamflow information is used to predict floods, manage and allocate water resources, design engineering structures, compute water-quality loads, and operate water-control structures. The current (2007) size of the USGS streamgaging network is over 7,400 streamgages nationwide. The USGS has progressively improved the streamgaging program by incorporating new technologies and techniques that streamline data collection while increasing the quality of the streamflow data that are collected. The single greatest change in streamflow measurement technology during the last 100 years has been the development and application of high frequency acoustic instruments for measuring streamflow. One such instrument, the acoustic Doppler current profiler (ADCP), is rapidly replacing traditional mechanical current meters for streamflow measurement (Muste and others, 2007). For more information on how an ADCP works see Simpson (2001) or visit http://hydroacoustics.usgs.gov/. The USGS has used ADCPs attached to manned or tethered boats since the mid-1990s to measure streamflow in a wide variety of conditions (fig. 1). Recent analyses have shown that ADCP streamflow measurements can be made with similar or greater accuracy, efficiency, and resolution than measurements made using conventional current-meter methods (Oberg and Mueller, 2007). ADCPs also have the ability to measure streamflow in streams where traditional current-meter measurements previously were very difficult or costly to obtain, such as streams affected by backwater or tides. In addition to streamflow measurements, the USGS also uses ADCPs for other hydrologic measurements and applications, such as computing continuous records of streamflow for tidally or backwater affected streams, measuring velocity fields with high spatial and temporal resolution, and estimating suspended-sediment concentrations. An overview

Statistical modelling of transcript profiles of differentially regulated genes

Directory of Open Access Journals (Sweden)

Sergeant Martin J

2008-07-01

Full Text Available Abstract Background The vast quantities of gene expression profiling data produced in microarray studies, and the more precise quantitative PCR, are often not statistically analysed to their full potential. Previous studies have summarised gene expression profiles using simple descriptive statistics, basic analysis of variance (ANOVA and the clustering of genes based on simple models fitted to their expression profiles over time. We report the novel application of statistical non-linear regression modelling techniques to describe the shapes of expression profiles for the fungus Agaricus bisporus, quantified by PCR, and for E. coli and Rattus norvegicus, using microarray technology. The use of parametric non-linear regression models provides a more precise description of expression profiles, reducing the "noise" of the raw data to produce a clear "signal" given by the fitted curve, and describing each profile with a small number of biologically interpretable parameters. This approach then allows the direct comparison and clustering of the shapes of response patterns between genes and potentially enables a greater exploration and interpretation of the biological processes driving gene expression. Results Quantitative reverse transcriptase PCR-derived time-course data of genes were modelled. "Split-line" or "broken-stick" regression identified the initial time of gene up-regulation, enabling the classification of genes into those with primary and secondary responses. Five-day profiles were modelled using the biologically-oriented, critical exponential curve, y(t = A + (B + CtRt + ε. This non-linear regression approach allowed the expression patterns for different genes to be compared in terms of curve shape, time of maximal transcript level and the decline and asymptotic response levels. Three distinct regulatory patterns were identified for the five genes studied. Applying the regression modelling approach to microarray-derived time course data

Criminal psychological profiling of serial arson crimes.

Science.gov (United States)

Kocsis, Richard N; Cooksey, Ray W

2002-12-01

The practice of criminal psychological profiling is frequently cited as being applicable to serial arson crimes. Despite this claim, there does not appear to be any empirical research that examines serial arson offence behaviors in the context of profiling. This study seeks to develop an empirical model of serial arsonist behaviors that can be systematically associated with probable offender characteristics. Analysis has produced a model of offence behaviors that identify four discrete behavior patterns, all of which share a constellation of common nondiscriminatory behaviors. The inherent behavioral themes of each of these patterns are explored with discussion of their broader implications for our understanding of serial arson and directions for future research.

Development of Cold Neutron Depth Profiling System at HANARO

International Nuclear Information System (INIS)

Park, B. G.; Choi, H. D.; Sun, G. M.

2012-01-01

The depth profiles of intentional or intrinsic constituents of a sample provide valuable information for the characterization of materials. A number of analytical techniques for depth profiling have been developed. Neutron Depth Profiling (NDP) system which was developed by Ziegler et al. is one of the leading analytical techniques. In NDP, a thermal or cold neutron beam passes through a material and interacts with certain isotopes that are known to emit monoenergetic-charged particle remaining a recoil nucleus after neutron absorption. The depth is obtained from the energy loss of those charged particles escaping surface of substrate material. For various applications of NDP technique, the Cold Neutron Depth Profiling System (CN-NDP) was developed at a neutron guide CG1 installed at the HANARO cold neutron source. In this study the design features of the cold neutron beam and target chamber for the CN-NDP system are given. Also, some experiments for the performance tests of the CN-NDP system are described

Probabilistic risk assessment methodology for risk management and regulatory applications

International Nuclear Information System (INIS)

See Meng Wong; Kelly, D.L.; Riley, J.E.

1997-01-01

This paper discusses the development and potential applications of PRA methodology for risk management and regulatory applications in the U.S. nuclear industry. The new PRA methodology centers on the development of This paper discusses the time-dependent configuration risk profile for evaluating the effectiveness of operational risk management programs at U.S. nuclear power plants. Configuration-risk profiles have been used as risk-information tools for (1) a better understanding of the impact of daily operational activities on plant safety, and (2) proactive planning of operational activities to manage risk. Trial applications of the methodology were undertaken to demonstrate that configuration-risk profiles can be developed routinely, and can be useful for various industry and regulatory applications. Lessons learned include a better understanding of the issues and characteristics of PRA models available to industry, and identifying the attributes and pitfalls in the developement of risk profiles

Mineral constituents profile of biochar derived from diversified waste biomasses: implications for agricultural applications.

Science.gov (United States)

Zhao, Ling; Cao, Xinde; Wang, Qun; Yang, Fan; Xu, Shi

2013-01-01

The wide distribution and high heterogeneity of different elements in biochars derived from diverse feedstocks make it difficult to regulate their application in soil and to evaluate the maximum potential contribution of the nutrients and trace metals as well as the potential risk of toxic metals. This study classified 20 biochars, covering six typical categories, into three clusters according to their similarity and distance on nutrients and minerals using cluster analysis. Four principle components (PC) were extracted using factor analysis to reduce dimension and clearly characterize the mineral profile of these biochars. The contribution of each group of elements in the PCs to every cluster was clarified. PC1 had a high loading for Mg, Cu, Zn, Al, and Fe; PC2 was related to N, K, and Mn; and PC3 and PC4 mainly represented P and Ca. Cluster 1 included bone dregs and eggshell biochars with PC3 and PC4 as the main contributors. Cluster 2 included waterweeds and waste paper biochars, which were close to shrimp hull and chlorella biochars, with the main contributions being from PC2 and PC4. Cluster 3 included biochars with PC1 as the main contributor. At a soil biochar amendment rate of 50 t ha, the soil nutrients were significantly elevated, whereas the rise in toxic metals was negligible compared with Class I of the China Environmental Quality Standards for Soil. Biochar can potentially supply soil nutrients and trace metals, and different cluster biochars can be applied appropriately to different soils so that excessive or deficient nutrient and metal applications can be avoided. Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc.

Digital Elevation Profile: A Complex Tool for the Spatial Analysis of Hiking

Directory of Open Access Journals (Sweden)

Laura TÎRLĂ

2014-11-01

Full Text Available One of the current attributions of mountain geomorphology is to provide information for tourism purposes, such as the spatial analysis of hiking trails. Therefore, geomorphic tools are indispensable for terrain analyses. Elevation profile is one of the most adequate tools for assessing the morphometric patterns of the hiking trails. In this study we tested several applications in order to manage raw data, create profile graphs and obtain the morphometric parameters of five hiking trails in the Căpățânii Mountains (South Carpathians, Romania. Different data complexity was explored: distance, elevation, cumulative gain or loss, slope etc. Furthermore, a comparative morphometric analysis was performed in order to emphasize the multiple possibilities provided by the elevation profile. Results show that GPS Visualizer, Geocontext and in some manner Google Earth are the most adequate applications that provide high-quality elevation profiles and detailed data, with multiple additional functions, according to user's needs. The applied tools and techniques are very useful for mountain route planning, elaborating mountain guides, enhancing knowledge about specific trails or routes, or assessing the landscape and tourism value of a mountain area.

A streamlined ribosome profiling protocol for the characterization of microorganisms

DEFF Research Database (Denmark)

Latif, Haythem; Szubin, Richard; Tan, Justin

2015-01-01

Ribosome profiling is a powerful tool for characterizing in vivo protein translation at the genome scale, with multiple applications ranging from detailed molecular mechanisms to systems-level predictive modeling. Though highly effective, this intricate technique has yet to become widely used...... in the microbial research community. Here we present a streamlined ribosome profiling protocol with reduced barriers to entry for microbial characterization studies. Our approach provides simplified alternatives during harvest, lysis, and recovery of monosomes and also eliminates several time-consuming steps...

Photovoltaic applications

International Nuclear Information System (INIS)

Sidrach, M.

1992-01-01

The most common terrestrial applications of photovoltaic plants are reviewed. Classification of applications can be done considering end-use sectors and load profiles (consumption demand). For those systems with direct coupling the working point is determined by the intersection of the load line with the I-V curve Design guidelines are provided for photovoltaic systems. This lecture focusses on the distribution system and safeguards

Fatty Acid Profile and Physicochemical Properties of Landolphia ...

African Journals Online (AJOL)

Purpose: To elucidate lipid profile of Landolphia owariensis P. Beauv stringy seed oil, the bulk physicochemical properties of its neutral lipid (NL), and also to ascertain its nutritional properties, safety and industrial applications. Methods: The neutral lipid was recovered by macerating 500 g of L. owariensis stringy seed pulp ...

Profile of Hospitalized Elderly Patients Treated for Falling

Directory of Open Access Journals (Sweden)

Yu-Ling Hsiao

2012-03-01

Conclusion: This study utilized actual nationwide data to provide a profile of elderly patients treated for falling in Taiwan. Based on the results of this study, fall prevention should especially target the female elderly, and should be given more emphasis during the winter season, in terms of clinical and policy applications.

Design of characteristic parameters for controlling tungsten tip profile during electrochemical etching

Energy Technology Data Exchange (ETDEWEB)

Le Duy Cuong; Duong, Thanh Hung; Kim, Huyn Chul [Inje University, Gimhae (Korea, Republic of)

2014-05-15

Micro/nano-scale tungsten tips fabricated by electrochemical etching have many diverse industrial applications. The characteristic parameters of the tungsten tip profile include apex radius, taper angle, and aspect ratio. These parameters are governed by many factors including applied voltage, concentration of the electrolyte (potassium hydroxide) solution, and diameter of the inner gold ring. However, a systematic investigation with the aim of determining the best conditions for fabricating micro/nano-scale tips with desired profiles has not been carried out yet. This study is aimed at obtaining controllable tungsten tip -particularly with respect to the radius of curvature and aspect ratio of tips (taper angle)-by altering the experimental conditions. A series of experiments were executed and the results were aggregated and analyzed using response surface methodology in order to identify the relationships between the tungsten tip characteristics and input parameters. The method proposed herein would prove to be suitable for a variety of applications in industries that require tungsten tips with a specific profile.

Design of characteristic parameters for controlling tungsten tip profile during electrochemical etching

International Nuclear Information System (INIS)

Le Duy Cuong; Duong, Thanh Hung; Kim, Huyn Chul

2014-01-01

Micro/nano-scale tungsten tips fabricated by electrochemical etching have many diverse industrial applications. The characteristic parameters of the tungsten tip profile include apex radius, taper angle, and aspect ratio. These parameters are governed by many factors including applied voltage, concentration of the electrolyte (potassium hydroxide) solution, and diameter of the inner gold ring. However, a systematic investigation with the aim of determining the best conditions for fabricating micro/nano-scale tips with desired profiles has not been carried out yet. This study is aimed at obtaining controllable tungsten tip -particularly with respect to the radius of curvature and aspect ratio of tips (taper angle)-by altering the experimental conditions. A series of experiments were executed and the results were aggregated and analyzed using response surface methodology in order to identify the relationships between the tungsten tip characteristics and input parameters. The method proposed herein would prove to be suitable for a variety of applications in industries that require tungsten tips with a specific profile

Depth profiling of transport properties of in-situ grown YBa_2Cu_3O_7-x films for coated conductor applications

Science.gov (United States)

Jo, William; Huh, J.-U.; Hammond, R. H.; Beasley, M. R.

2003-03-01

We report depth profiling of the local critical current density and resistivity of YBa_2Cu_3O_7-x (YBCO) films grown by in-situ electron beam evaporation. The method provides important information on the uniformity of the films, and therefore on the commonly observed property that the critical currents of coated conductor high temperature superconductor films do not scale linearly with thickness. Using a methodology of layer-by-layer etching, depth profiling of critical currents and resistivity of the films has been achieved. We use a Bromine methanol mixture to etch down YBCO films with an etch rate of 60 nm/min. At each step, we also observe surface morphology using high resolution scanning electron microscopy. In this talk, we report further study of the results found earlier that YBCO films deposited at high rates are composed of an upper layer of defected YBCO with a local Jc of 5 - 7 MA/cm^2 and a lower more perfect layer with no critical current capacity. The information derived may be useful in the characterization and optimization of superconducting thin films for electrical power and other applications.

New fuzzy EWMA control charts for monitoring phase II fuzzy profiles

Directory of Open Access Journals (Sweden)

Ghazale Moghadam

2016-01-01

Full Text Available In many quality control applications, the quality of a process or product is explained by the relationship between response variable and one or more explanatory variables, called a profile. In this paper, a new fuzzy EWMA control chart for phase II fuzzy profile monitoring is proposed. To this end, we extend EWMA control charts to its equivalent Fuzzy type and then implement fuzzy ranking methods to determine whether the process fuzzy profile is under or out of control. The proposed method is capable of identifying small changes in process under condition of process profile explaining parameters vagueness, roughness and uncertainty. Determining the source of changes, this method provides us with the possibility of recognizing the causes of process transition from stable mode, removing these causes and restoring the process stable mode.

Deciphering Phosphotyrosine-Dependent Signaling Networks in Cancer by SH2 Profiling

Science.gov (United States)

Machida, Kazuya; Khenkhar, Malik

2012-01-01

It has been a decade since the introduction of SH2 profiling, a modular domain-based molecular diagnostics tool. This review covers the original concept of SH2 profiling, different analytical platforms, and their applications, from the detailed analysis of single proteins to broad screening in translational research. Illustrated by practical examples, we discuss the uniqueness and advantages of the approach as well as its limitations and challenges. We provide guidance for basic researchers and oncologists who may consider SH2 profiling in their respective cancer research, especially for those focusing on tyrosine phosphoproteomics. SH2 profiling can serve as an alternative phosphoproteomics tool to dissect aberrant tyrosine kinase pathways responsible for individual malignancies, with the goal of facilitating personalized diagnostics for the treatment of cancer. PMID:23226573

SU-E-T-149: Electron Beam Profile Differences Between Elekta MLCi2 and Elekta Agility Treatment Heads

Energy Technology Data Exchange (ETDEWEB)

Wu, C [Sutter Medical Foundation, Roseville, CA 95661 (United States); Hatcher, C [Sutter Shared Services S3, Sacramento, CA (United States)

2014-06-01

Purpose: To report and investigate observed differences in electron beam profiles at various energies/applicators between Elekta MLCi2 and Agility treatment head on Elekta Infinity LINAC Methods: When we upgraded from MLCi2 to Agility on one of our Elekta Infinity LINAC's, electron beam PDDs and profiles were acquired for comparison purpose. All clinical electron energies (6/9/12/15/12/18 MeV) and electron applicators (6/10/14/20/25 square) were included in measurement. PDDs were acquired at 100 SSD in water (PTW MP3 water tank) with a plane-parallel ion chamber (PTW Roos). X and Y Profiles were acquired using IC Profiler (Sun Nuclear Corp.) at 1cm and maximum PDD depths (water equivalent). Results: All PDD curves match very well between MLCi2 and Agility treatment head. However, some significant differences on electron profiles were found. On Agility, even after increasing the default auto-tracking offset values for backup diaphragms in Y and MLC in X by 2.8 cm (the maximum allowed change is 3.0 cm), electron profiles still have rounder shoulders comparing to corresponding MLCi2 profiles. This difference is significantly more pronounced at larger applicators (20 and 25 square), for all electron energies. Conclusion: The significant design change between MLCi2 and Agility beam limiting device seems to affect exit electron beam profiles. In IEC1217 X direction, the main change on Agility is the removal of the original MLCi2 X backup diaphragms and replacing it with MLC leaves; In Y direction, the main change is the radius and materials on Y backup diaphragms.

Computational resources for ribosome profiling: from database to Web server and software.

Science.gov (United States)

Wang, Hongwei; Wang, Yan; Xie, Zhi

2017-08-14

Ribosome profiling is emerging as a powerful technique that enables genome-wide investigation of in vivo translation at sub-codon resolution. The increasing application of ribosome profiling in recent years has achieved remarkable progress toward understanding the composition, regulation and mechanism of translation. This benefits from not only the awesome power of ribosome profiling but also an extensive range of computational resources available for ribosome profiling. At present, however, a comprehensive review on these resources is still lacking. Here, we survey the recent computational advances guided by ribosome profiling, with a focus on databases, Web servers and software tools for storing, visualizing and analyzing ribosome profiling data. This review is intended to provide experimental and computational biologists with a reference to make appropriate choices among existing resources for the question at hand. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Evolution of radial profiles in regular Lemaitre-Tolman-Bondi dust models

International Nuclear Information System (INIS)

Sussman, Roberto A

2010-01-01

We undertake a comprehensive and rigorous analytic study of the evolution of radial profiles of covariant scalars in regular LemaItre-Tolman-Bondi (LTB) dust models. We consider specifically the phenomenon of 'profile inversions' in which an initial clump profile of density, spatial curvature or the expansion scalar might evolve into a void profile (and vice versa). Previous work in the literature on models with density void profiles and/or allowing for density profile inversions is given full generalization, with some erroneous results corrected. We prove rigorously that if an evolution without shell crossings is assumed, then only the 'clump to void' inversion can occur in density profiles, and only in hyperbolic models or regions with negative spatial curvature. The profiles of spatial curvature follow similar patterns as those of the density, with 'clump to void' inversions only possible for hyperbolic models or regions. However, profiles of the expansion scalar are less restrictive, with profile inversions necessarily taking place in elliptic models. We also examine radial profiles in special LTB configurations: closed elliptic models, models with a simultaneous big bang singularity, as well as a locally collapsing elliptic region surrounded by an expanding hyperbolic background. The general analytic statements that we obtain allow for setting up the right initial conditions to construct fully regular LTB models with any specific qualitative requirements for the profiles of all scalars and their time evolution. The results presented can be very useful in guiding future numerical work on these models and in revising previous analytic work on all their applications.

Polydisperse-particle-size-distribution function determined from intensity profile of angularly scattered light

International Nuclear Information System (INIS)

Alger, T.W.

1979-01-01

A new method for determining the particle-size-distribution function of a polydispersion of spherical particles is presented. The inversion technique for the particle-size-distribution function is based upon matching the measured intensity profile of angularly scattered light with a summation of the intensity contributions of a series of appropriately spaced, narrowband, size-distribution functions. A numerical optimization technique is used to determine the strengths of the individual bands that yield the best agreement with the measured scattered-light-intensity profile. Because Mie theory is used, the method is applicable to spherical particles of all sizes. Several numerical examples demonstrate the application of this inversion method

DETERMINATION ОF DRESS ROLL OPTIMAL RADIUS WHILE PRODUCING PARTS WITH TROCHOIDAL PROFILE

Directory of Open Access Journals (Sweden)

E. N. Yankevich

2008-01-01

Full Text Available The paper considers determination of the dress roll optimal radius while producing parts having trohoidal profile with the help of grinding method that presupposes application of grinding disk. In this case disk profile has been cut-in by diamond dressing. Two methods for determination of calculation of the dress roll optimal radius have been proposed in the paper. On the basis of the satellite gear of the planetary pin reducer whose profile presents a trochoid it has been shown that the obtained results pertaining to two proposed methods conform with each other.

Rapid descriptive sensory methods – Comparison of Free Multiple Sorting, Partial Napping, Napping, Flash Profiling and conventional profiling

DEFF Research Database (Denmark)

Dehlholm, Christian; Brockhoff, Per B.; Meinert, Lene

2012-01-01

is a modal restriction of Napping to specific sensory modalities, directing sensation and still allowing a holistic approach to products. The new methods are compared to Flash Profiling, Napping and conventional descriptive sensory profiling. Evaluations are performed by several panels of expert assessors......Two new rapid descriptive sensory evaluation methods are introduced to the field of food sensory evaluation. The first method, free multiple sorting, allows subjects to perform ad libitum free sortings, until they feel that no more relevant dissimilarities among products remain. The second method...... are applied for the graphical validation and comparisons. This allows similar comparisons and is applicable to single-block evaluation designs such as Napping. The partial Napping allows repetitions on multiple sensory modalities, e.g. appearance, taste and mouthfeel, and shows the average...

An Electron Beam Profile Instrument Based on FBGs

Directory of Open Access Journals (Sweden)

Dan Sporea

2014-08-01

Full Text Available Along with the dose rate and the total irradiation dose measurements, the knowledge of the beam localization and the beam profile/energy distribution in the beam are parameters of interest for charged particle accelerator installations when they are used in scientific investigations, industrial applications or medical treatments. The transverse profile of the beam, its position, its centroid location, and its focus or flatness depend on the instrument operating conditions or on the beam exit setup. Proof-of-concept of a new type of charged particle beam diagnostics based on fiber Bragg gratings (FBGs was demonstrated. Its operating principle relies on the measurement of the peak wavelength changes for an array of FBG sensors as function of the temperature following the exposure to an electron beam. Periodically, the sensor irradiation is stopped and the FBG are force cooled to a reference temperature with which the temperature influencing each sensor during beam exposure is compared. Commercially available FBGs, and FBGs written in radiation resistant optical fibers, were tested under electron beam irradiation in order to study their possible use in this application.

Current profile evolution during fast wave current drive on the DIII-D tokamak

International Nuclear Information System (INIS)

Petty, C.C.; Forest, C.B.; Baity, F.W.

1995-06-01

The effect of co and counter fast wave current drive (FWCD) on the plasma current profile has been measured for neutral beam heated plasmas with reversed magnetic shear on the DIII-D tokamak. Although the response of the loop voltage profile was consistent with the application of co and counter FWCD, little difference was observed between the current profiles for the opposite directions of FWCD. The evolution of the current profile was successfully modeled using the ONETWO transport code. The simulation showed that the small difference between the current profiles for co and counter FWCD was mainly due to an offsetting change in the o at sign c current proffie. In addition, the time scale for the loop voltage to reach equilibrium (i.e., flatten) was found to be much longer than the FWCD pulse, which limited the ability of the current profile to fully respond to co or counter FWCD

Consumer involvement profiles: An application of consumer involvement in mobile industry

OpenAIRE

Homa Rahbarian; Fattaneh Alizadeh Meshkani

2014-01-01

This paper investigates consumer involvement profile among people who intend to purchase mobile devises. The study considers the effects of various factors influencing on purchase intention including consumers’ personal characteristics such as age, gender, income as well as some external factors including advertisement. The study uses a questionnaire in Likert scale, originally developed by O’Cass (2000) [O’Cass, A. (2000). An assessment of consumers' product, purchase decision, advertising a...

Data Profiling

OpenAIRE

Hladíková, Radka

2010-01-01

Title: Data Profiling Author: Radka Hladíková Department: Department of Software Engineering Supervisor: Ing. Vladimír Kyjonka Supervisor's e-mail address: Abstract: This thesis puts mind on problems with data quality and data profiling. This Work analyses and summarizes problems of data quality, data defects, process of data quality, data quality assessment and data profiling. The main topic is data profiling as a process of researching data available in existing...

APPLICATION OF A SELF-SIMILAR PRESSURE PROFILE TO SUNYAEV-ZEL'DOVICH EFFECT DATA FROM GALAXY CLUSTERS

International Nuclear Information System (INIS)

Mroczkowski, Tony; Miller, Amber; Bonamente, Max; Carlstrom, John E.; Culverhouse, Thomas L.; Greer, Christopher; Hennessy, Ryan; Leitch, Erik M.; Loh, Michael; Marrone, Daniel P.; Pryke, Clem; Sharp, Matthew; Hawkins, David; Lamb, James W.; Woody, David; Joy, Marshall; Maughan, Ben; Muchovej, Stephen; Nagai, Daisuke

2009-01-01

We investigate the utility of a new, self-similar pressure profile for fitting Sunyaev-Zel'dovich (SZ) effect observations of galaxy clusters. Current SZ imaging instruments-such as the Sunyaev-Zel'dovich Array (SZA)-are capable of probing clusters over a large range in a physical scale. A model is therefore required that can accurately describe a cluster's pressure profile over a broad range of radii from the core of the cluster out to a significant fraction of the virial radius. In the analysis presented here, we fit a radial pressure profile derived from simulations and detailed X-ray analysis of relaxed clusters to SZA observations of three clusters with exceptionally high-quality X-ray data: A1835, A1914, and CL J1226.9+3332. From the joint analysis of the SZ and X-ray data, we derive physical properties such as gas mass, total mass, gas fraction and the intrinsic, integrated Compton y-parameter. We find that parameters derived from the joint fit to the SZ and X-ray data agree well with a detailed, independent X-ray-only analysis of the same clusters. In particular, we find that, when combined with X-ray imaging data, this new pressure profile yields an independent electron radial temperature profile that is in good agreement with spectroscopic X-ray measurements.

Scrape-off layer profile modifications by convective cells

International Nuclear Information System (INIS)

Myra, J.R.; DIppolito, D.A.

1996-01-01

Convective cells (CC close-quote s) are important in understanding density profile modifications induced by ion cyclotron range of frequencies (ICRF) antennas. This has motivated the present work in which the effect of CC close-quote s on transport in the scrape-off layer is studied, in the regime where the density gradient scale length L n and the cell size L are comparable. Monte Carlo simulations show that closed cell convection acts to flatten the density profile, and that open cells enhance the particle flow to the wall, depleting the density and yielding profiles similar to those measured near ICRF antennas. A new one-dimensional, two-branch model of CC transport is shown to agree well with the simulations. The model gives rise to two characteristic scale lengths, only one of which is retained in the enhanced diffusion models that are applicable for L n >L. The two-branch model is expected to be useful in analyzing ICRF experiments. copyright 1996 American Institute of Physics

Two-photon equivalent weighting of spatial excimer laser beam profiles

Science.gov (United States)

Eva, Eric; Bauer, Harry H.; Metzger, K.; Pfeiffer, A.

2001-04-01

Damage in optical materials for semiconductor lithography applications caused by exposure to 248 or 193 nm light is usually two-photon driven, hence it is a nonlinear function of incident intensity. Materials should be tested with flat- topped temporal and spatial laser beam profiles to facilitate interpretation of data, but in reality this is hard to achieve. Sandstrom provided a formula that approximates any given temporal pulse shape with a two- photon equivalent rectangular pulse (Second Symposium on 193 nm Lithography, Colorado Springs 1997). Known as the integral-square pulse duration, this definition has been embraced as an industry standard. Originally faced with the problem of comparing results obtained with pseudo-Gaussian spatial profiles to literature data, we found that a general solution for arbitrarily inhomogeneous spatial beam profiles exists which results in a definition much similar to Sandstrom's. In addition, we proved the validity of our approach in experiments with intentionally altered beam profiles.

Globus Nexus: A Platform-as-a-Service Provider of Research Identity, Profile, and Group Management.

Science.gov (United States)

Chard, Kyle; Lidman, Mattias; McCollam, Brendan; Bryan, Josh; Ananthakrishnan, Rachana; Tuecke, Steven; Foster, Ian

2016-03-01

Globus Nexus is a professionally hosted Platform-as-a-Service that provides identity, profile and group management functionality for the research community. Many collaborative e-Science applications need to manage large numbers of user identities, profiles, and groups. However, developing and maintaining such capabilities is often challenging given the complexity of modern security protocols and requirements for scalable, robust, and highly available implementations. By outsourcing this functionality to Globus Nexus, developers can leverage best-practice implementations without incurring development and operations overhead. Users benefit from enhanced capabilities such as identity federation, flexible profile management, and user-oriented group management. In this paper we present Globus Nexus, describe its capabilities and architecture, summarize how several e-Science applications leverage these capabilities, and present results that characterize its scalability, reliability, and availability.

Globus Nexus: A Platform-as-a-Service provider of research identity, profile, and group management

Energy Technology Data Exchange (ETDEWEB)

Chard, Kyle; Lidman, Mattias; McCollam, Brendan; Bryan, Josh; Ananthakrishnan, Rachana; Tuecke, Steven; Foster, Ian

2016-03-01

Globus Nexus is a professionally hosted Platform-as-a-Service that provides identity, profile and group management functionality for the research community. Many collaborative e-Science applications need to manage large numbers of user identities, profiles, and groups. However, developing and maintaining such capabilities is often challenging given the complexity of modern security protocols and requirements for scalable, robust, and highly available implementations. By outsourcing this functionality to Globus Nexus, developers can leverage best-practice implementations without incurring development and operations overhead. Users benefit from enhanced capabilities such as identity federation, flexible profile management, and user-oriented group management. In this paper we present Globus Nexus, describe its capabilities and architecture, summarize how several e-Science applications leverage these capabilities, and present results that characterize its scalability, reliability, and availability.

PWR AXIAL BURNUP PROFILE ANALYSIS

International Nuclear Information System (INIS)

J.M. Acaglione

2003-01-01

The purpose of this activity is to develop a representative ''limiting'' axial burnup profile for pressurized water reactors (PWRs), which would encompass the isotopic axial variations caused by different assembly irradiation histories, and produce conservative isotopics with respect to criticality. The effect that the low burnup regions near the ends of spent fuel have on system reactivity is termed the ''end-effect''. This calculation will quantify the end-effects associated with Pressurized Water Reactor (PWR) fuel assemblies emplaced in a hypothetical 21 PWR waste package. The scope of this calculation covers an initial enrichment range of 3.0 through 5.0 wt% U-235 and a burnup range of 10 through 50 GWd/MTU. This activity supports the validation of the process for ensuring conservative generation of spent fuel isotopics with respect to criticality safety applications, and the use of burnup credit for commercial spent nuclear fuel. The intended use of these results will be in the development of PWR waste package loading curves, and applications involving burnup credit. Limitations of this evaluation are that the limiting profiles are only confirmed for use with the B andW 15 x 15 fuel assembly design. However, this assembly design is considered bounding of all other typical commercial PWR fuel assembly designs. This calculation is subject to the Quality Assurance Requirements and Description (QARD) because this activity supports investigations of items or barriers on the Q-list (YMP 2001)

Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection

Science.gov (United States)

Miyagi, Yohei; Higashiyama, Masahiko; Gochi, Akira; Akaike, Makoto; Ishikawa, Takashi; Miura, Takeshi; Saruki, Nobuhiro; Bando, Etsuro; Kimura, Hideki; Imamura, Fumio; Moriyama, Masatoshi; Ikeda, Ichiro; Chiba, Akihiko; Oshita, Fumihiro; Imaizumi, Akira; Yamamoto, Hiroshi; Miyano, Hiroshi; Horimoto, Katsuhisa; Tochikubo, Osamu; Mitsushima, Toru; Yamakado, Minoru; Okamoto, Naoyuki

2011-01-01

Background Recently, rapid advances have been made in metabolomics-based, easy-to-use early cancer detection methods using blood samples. Among metabolites, profiling of plasma free amino acids (PFAAs) is a promising approach because PFAAs link all organ systems and have important roles in metabolism. Furthermore, PFAA profiles are known to be influenced by specific diseases, including cancers. Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection. Methods and Findings Plasma samples were collected from approximately 200 patients from multiple institutes, each diagnosed with one of the following five types of cancer: lung, gastric, colorectal, breast, or prostate cancer. Patients were compared to gender- and age- matched controls also used in this study. The PFAA levels were measured using high-performance liquid chromatography (HPLC)–electrospray ionization (ESI)–mass spectrometry (MS). Univariate analysis revealed significant differences in the PFAA profiles between the controls and the patients with any of the five types of cancer listed above, even those with asymptomatic early-stage disease. Furthermore, multivariate analysis clearly discriminated the cancer patients from the controls in terms of the area under the receiver-operator characteristics curve (AUC of ROC >0.75 for each cancer), regardless of cancer stage. Because this study was designed as case-control study, further investigations, including model construction and validation using cohorts with larger sample sizes, are necessary to determine the usefulness of PFAA profiling. Conclusions These findings suggest that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis. PFAA profiles can also be used to determine various disease diagnoses from a single blood sample, which involves a relatively simple

Plasma free amino acid profiling of five types of cancer patients and its application for early detection.

Directory of Open Access Journals (Sweden)

Yohei Miyagi

Full Text Available BACKGROUND: Recently, rapid advances have been made in metabolomics-based, easy-to-use early cancer detection methods using blood samples. Among metabolites, profiling of plasma free amino acids (PFAAs is a promising approach because PFAAs link all organ systems and have important roles in metabolism. Furthermore, PFAA profiles are known to be influenced by specific diseases, including cancers. Therefore, the purpose of the present study was to determine the characteristics of the PFAA profiles in cancer patients and the possibility of using this information for early detection. METHODS AND FINDINGS: Plasma samples were collected from approximately 200 patients from multiple institutes, each diagnosed with one of the following five types of cancer: lung, gastric, colorectal, breast, or prostate cancer. Patients were compared to gender- and age- matched controls also used in this study. The PFAA levels were measured using high-performance liquid chromatography (HPLC-electrospray ionization (ESI-mass spectrometry (MS. Univariate analysis revealed significant differences in the PFAA profiles between the controls and the patients with any of the five types of cancer listed above, even those with asymptomatic early-stage disease. Furthermore, multivariate analysis clearly discriminated the cancer patients from the controls in terms of the area under the receiver-operator characteristics curve (AUC of ROC >0.75 for each cancer, regardless of cancer stage. Because this study was designed as case-control study, further investigations, including model construction and validation using cohorts with larger sample sizes, are necessary to determine the usefulness of PFAA profiling. CONCLUSIONS: These findings suggest that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis. PFAA profiles can also be used to determine various disease diagnoses from a single blood sample, which involves a

Photodegradation of wood and depth profile analysis

International Nuclear Information System (INIS)

Kataoka, Y.

2008-01-01

Photochemical degradation is a key process of the weathering that occurs when wood is exposed outdoors. It is also a major cause of the discoloration of wood in indoor applications. The effects of sunlight on the chemical composition of wood are superficial in nature, but estimates of the depth at which photodegradation occurs in wood vary greatly from 80 microm to as much as 2540 mic rom. Better understanding of the photodegradation of wood through depth profile analysis is desirable because it would allow the development of more effective photo-protective treatments that target the surface layers of wood most susceptible to photodegradation. This paper briefly describes fundamental aspects of photodegradation of wood and reviews progress made in the field of depth profile study on the photodegradation of wood. (author)

On the line-shape analysis of Compton profiles and its application to neutron scattering

International Nuclear Information System (INIS)

Romanelli, G.; Krzystyniak, M.

2016-01-01

Analytical properties of Compton profiles are used in order to simplify the analysis of neutron Compton scattering experiments. In particular, the possibility to fit the difference of Compton profiles is discussed as a way to greatly decrease the level of complexity of the data treatment, making the analysis easier, faster and more robust. In the context of the novel method proposed, two mathematical models describing the shapes of differenced Compton profiles are discussed: the simple Gaussian approximation for harmonic and isotropic local potential, and an analytical Gauss–Hermite expansion for an anharmonic or anisotropic potential. The method is applied to data collected by VESUVIO spectrometer at ISIS neutron and muon pulsed source (UK) on Copper and Aluminium samples at ambient and low temperatures. - Highlights: • A new method to analyse neutron Compton scattering data is presented. • The method allows many corrections on the experimental data to be avoided. • The number of needed fitting parameters is drastically reduced using the new method. • Mass-selective analysis is facilitated with parametric studies benefiting the most. • Observables linked to anisotropic momentum distribution are obtained analytically.

Proposed method for reconstructing velocity profiles using a multi-electrode electromagnetic flow meter

International Nuclear Information System (INIS)

Kollár, László E; Lucas, Gary P; Zhang, Zhichao

2014-01-01

An analytical method is developed for the reconstruction of velocity profiles using measured potential distributions obtained around the boundary of a multi-electrode electromagnetic flow meter (EMFM). The method is based on the discrete Fourier transform (DFT), and is implemented in Matlab. The method assumes the velocity profile in a section of a pipe as a superposition of polynomials up to sixth order. Each polynomial component is defined along a specific direction in the plane of the pipe section. For a potential distribution obtained in a uniform magnetic field, this direction is not unique for quadratic and higher-order components; thus, multiple possible solutions exist for the reconstructed velocity profile. A procedure for choosing the optimum velocity profile is proposed. It is applicable for single-phase or two-phase flows, and requires measurement of the potential distribution in a non-uniform magnetic field. The potential distribution in this non-uniform magnetic field is also calculated for the possible solutions using weight values. Then, the velocity profile with the calculated potential distribution which is closest to the measured one provides the optimum solution. The reliability of the method is first demonstrated by reconstructing an artificial velocity profile defined by polynomial functions. Next, velocity profiles in different two-phase flows, based on results from the literature, are used to define the input velocity fields. In all cases, COMSOL Multiphysics is used to model the physical specifications of the EMFM and to simulate the measurements; thus, COMSOL simulations produce the potential distributions on the internal circumference of the flow pipe. These potential distributions serve as inputs for the analytical method. The reconstructed velocity profiles show satisfactory agreement with the input velocity profiles. The method described in this paper is most suitable for stratified flows and is not applicable to axisymmetric flows in

Metasurfaces-based holography and beam shaping: engineering the phase profile of light

Directory of Open Access Journals (Sweden)

Scheuer Jacob

2016-08-01

Full Text Available The ability to engineer and shape the phase profile of optical beams is in the heart of any optical element. Be it a simple lens or a sophisticated holographic element, the functionality of such components is dictated by their spatial phase response. In contrast to conventional optical components which rely on thickness variation to induce a phase profile, metasurfaces facilitate the realization of arbitrary phase distributions using large arrays with sub-wavelength and ultrathin (tens of nanometers features. Such components can be easily realized using a single lithographic step and is highly suited for patterning a variety of substrates, including nonplanar and soft surfaces. In this article, we review the recent developments, potential, and opportunities of metasurfaces applications. We focus primarily on flat optical devices, holography, and beam-shaping applications as these are the key ingredients needed for the development of a new generation of optical devices which could find widespread applications in photonics.

Shave-off depth profiling: Depth profiling with an absolute depth scale

International Nuclear Information System (INIS)

Nojima, M.; Maekawa, A.; Yamamoto, T.; Tomiyasu, B.; Sakamoto, T.; Owari, M.; Nihei, Y.

2006-01-01

Shave-off depth profiling provides profiling with an absolute depth scale. This method uses a focused ion beam (FIB) micro-machining process to provide the depth profile. We show that the shave-off depth profile of a particle reflected the spherical shape of the sample and signal intensities had no relationship to the depth. Through the introduction of FIB micro-sampling, the shave-off depth profiling of a dynamic random access memory (DRAM) tip was carried out. The shave-off profile agreed with a blue print from the manufacturing process. Finally, shave-off depth profiling is discussed with respect to resolutions and future directions

Extraction Analysis and Creation of Three-Dimensional Road Profiles Using Matlab OpenCRG Tool

Directory of Open Access Journals (Sweden)

Rakesh Hari Borse

2015-08-01

Full Text Available In vehicle systems dynamics there are wide applications of simulation of vehicles on road surfaces. These simulation applications are related to vehicle handling ride comfort and durability. For accurate prediction of results there is a need for a reliable and efficient road representations. The efficient representation of road surface profiles is to represent them in three-dimensional space. This is made possible by the CRG Curved Regular Grid approach. OpenCRG is a completely open source project including a tool suite for the creation modification and evaluation of road surfaces. Its objective is to standardized detailed road surface description and it may be used for applications like tire models vibrations or driving simulation. The Matlab tool suite of OpenCRG provides powerful modification or creation tools and allows to visualize the 3D road data representation. The current research focuses on basic concepts of OpenCRG and its Matlab environment. The extraction of longitudinal two-dimensional road profiles from three-dimensional CRG format is researched. The creation of simple virtual three-dimensional roads has been programmed. A Matlab software tool to extract create and analyze the three-dimensional road profiles is to be developed.

X-Ray Pulsar Profile Recovery Based on Tracking-Differentiator

Directory of Open Access Journals (Sweden)

Dapeng Zhang

2016-01-01

Full Text Available The profile recovery is an important work in X-ray pulsar-based navigation. It is a key step for the analysis on the pulsar signal’s characteristic and the computing of time of arrival (TOA. This paper makes an argument for an algorithm based on the tracking-differentiator (TD to recover the profile from the low Signal-to-Noise Ratio (SNR signals. In the method, a TD filter with cascade structure is designed which has very low phase delay and amplitude distortion. In the simulation experiment, two typical pulsars (PSR B0531+21 and PSR B1937+21 are used to verify the algorithm’s performance. The simulation results show that the method satisfies the application requirements in the aspects of SNR and profile fidelity. By processing the data collected by the Rossi X-Ray Timing Explorer (RXTE satellite in space, similar results can also be achieved.

Personality Profile Investigation of Adoption Applicant Couples in Arak, 2014

Directory of Open Access Journals (Sweden)

Hamid Reza Jamilian

2016-06-01

Full Text Available Abstract Background: Adoption has a significant role for strengthening families without children and also resolution of psychological confilicts of unsupervised children. The goal of this study is to assess the psychological status of adoption applicant couples. Materials and Methods: This is a descriptive- analytic study that is done with cooperation of welfare organization and Arak University of Medical Sciences in 2014. All adoption applicant couples referred to welfare organization for 1 year participated in the study. Data were gathered by using demographic questionnaire and MMPI-II. Data were showed by descriptive statistic and were analyzed by using mean, average and covariance analysis indices. Results: Mean and standard deviation of all clinical scales and reliability of MMPI-II in all samples and also different subgroups of statistical population were under 65. All applicants had good mental health and psychologically were eligible for adoption. A group of applicants have pretended themselves better than what they are because of the fear of rejection that led to significant difference in k scale(p=0.019. Conclusion: According to the findings of this study, applicants had good mental health and didn’t have any psychopathologic damage, but sometimes they have pretended themselves better than what they are. Investigation of other diagnostic tools in future studies is recommended.

Profiling application potential for alkali treated sisal fiber ...

African Journals Online (AJOL)

The effect of alkali treatment on sisal fiber from the plant agave sisalana in appropriation for composite material application is presented. Effectiveness of the fiber's reinforcement potential within polypropylene (PP) matrix is evaluated through morphological analysis, crystallinity levels, and tensile, where ultimate tensile ...

Peripheral dose outside applicators in electron beams

International Nuclear Information System (INIS)

Chow, James C L; Grigorov, Grigor N

2006-01-01

The peripheral dose outside the applicators in electron beams was studied using a Varian 21 EX linear accelerator. To measure the peripheral dose profiles and point doses for the applicator, a solid water phantom was used with calibrated Kodak TL films. Peak dose spot was observed in the 4 MeV beam outside the applicator. The peripheral dose peak was very small in the 6 MeV beam and was ignorable at higher energies. Using the 10 x 10 cm 2 cutout and applicator, the dose peak for the 4 MeV beam was about 12 cm away from the field central beam axis (CAX) and the peripheral dose profiles did not change with depths measured at 0.2, 0.5 and 1 cm. The peripheral doses and profiles were further measured by varying the angle of obliquity, cutout and applicator size for the 4 MeV beam. The local peak dose was increased with about 3% per degree angle of obliquity, and was about 1% of the prescribed dose (angle of obliquity equals zero) at 1 cm depth in the phantom using the 10 x 10 cm 2 cutout and applicator. The peak dose position was also shifted 7 mm towards the CAX when the angle of obliquity was increased from 0 to 15 deg. (note)

Dielectric heating. Industrial applications; Chauffage dielectrique. Applications industrielles

Energy Technology Data Exchange (ETDEWEB)

Roussy, G. [Nancy-1 Univ. Henri Poincare, Dir. de Recherche 54 (France); Rochas, J.F. [Societe Sairem, 75 - Paris (France); Oberlin, C. [Electricite de France (EDF), Div. de Recherche, 75 - Paris (France)

2003-11-01

The heating of insulating or badly power conducting products using high frequency (HF) electromagnetic waves and microwaves (MW) is used in several industrial applications. This article presents some examples of conventional or recent applications of dielectric heating in the industry: 1 - selection criteria between HF and MW heating systems; 2 - HF applications: traditional applications (wood forming and sticking, welding of thermoplastic materials, drying of textile materials, correction of the humidity profile in the paper industry, end-baking of biscuits in the food industry), recent applications (over-moulding of automotive glazing materials, gluing and moulding of plastic parts in the automotive industry, drying of the coating of textile ropes), innovative applications; 3 - microwave applications: traditional applications (moderating of frozen meat by 915 MHz microwaves, drying of coatings on polystyrene or sand core models for foundry, pre-vulcanization of rubber sections, 2450 MHz pasteurization of pumpable products with morsels), examples of recent applications (continuous dehydration in vacuum, MW assisted granulator-dryers in the pharmaceutical industry, decontamination of hospital wastes), examples of innovative applications in the chemical sector, applications in progress; 4 - conclusion. (J.S.)

Linear chirped slope profile for spatial calibration in slope measuring deflectometry

Energy Technology Data Exchange (ETDEWEB)

Siewert, F., E-mail: frank.siewert@helmholtz-berlin.de; Zeschke, T. [Helmholtz Zentrum Berlin für Materialien und Energie, Institut für Nanometer Optik und Technologie, Albert-Einstein-Str. 15, 12489 Berlin (Germany); Arnold, T.; Paetzelt, H. [Leibnitz Institut für Oberflächen Modifizierung Leipzig e.V., IOM, Permoserstr. 15, 04318 Leipzig (Germany); Yashchuk, V. V. [Lawerence Berkeley National Laboratory, Advanced Light Source, 1 Cyclotron Road, Berkeley, California 94720 (United States)

2016-05-15

Slope measuring deflectometry is commonly used by the X-ray optics community to measure the long-spatial-wavelength surface figure error of optical components dedicated to guide and focus X-rays under grazing incidence condition at synchrotron and free electron laser beamlines. The best performing instruments of this kind are capable of absolute accuracy on the level of 30-50 nrad. However, the exact bandwidth of the measurements, determined at the higher spatial frequencies by the instrument’s spatial resolution, or more generally by the instrument’s modulation transfer function (MTF) is hard to determine. An MTF calibration method based on application of a test surface with a one-dimensional (1D) chirped height profile of constant amplitude was suggested in the past. In this work, we propose a new approach to designing the test surfaces with a 2D-chirped topography, specially optimized for MTF characterization of slope measuring instruments. The design of the developed MTF test samples based on the proposed linear chirped slope profiles (LCSPs) is free of the major drawback of the 1D chirped height profiles, where in the slope domain, the amplitude strongly increases with the local spatial frequency of the profile. We provide the details of fabrication of the LCSP samples. The results of first application of the developed test samples to measure the spatial resolution of the BESSY-NOM at different experimental arrangements are also presented and discussed.

Application of a Pivot Profile Variant Using CATA Questions in the Development of a Whey-Based Fermented Beverage

Directory of Open Access Journals (Sweden)

Marcelo Miraballes

2018-02-01

Full Text Available During the development of a food product, the application of rapid descriptive sensory methodologies is very useful to determine the influence of different variables on the sensory characteristics of the product under development. The Pivot profile (PP and a variant of the technique that includes check-all-that-apply questions (PP + CATA were used for the development of a milk drink fermented from demineralised sweet whey. Starting from a base formula of partially demineralised sweet whey and gelatin, nine samples were elaborated, to which various concentrations of commercial sucrose, modified cassava starch, and whole milk powder were added. Differences in sucrose content affected the sample texture and flavour and the modified starch was able to decrease the fluidity and increase the texture of creaminess and firmness, of the samples. The two applied sensory methodologies achieved good discrimination between the samples and very similar results, although the data analysis was clearly simplified in relation to the difficulty and time consumed in the PP + CATA variant.

Searching mixed DNA profiles directly against profile databases.

Science.gov (United States)

Bright, Jo-Anne; Taylor, Duncan; Curran, James; Buckleton, John

2014-03-01

DNA databases have revolutionised forensic science. They are a powerful investigative tool as they have the potential to identify persons of interest in criminal investigations. Routinely, a DNA profile generated from a crime sample could only be searched for in a database of individuals if the stain was from single contributor (single source) or if a contributor could unambiguously be determined from a mixed DNA profile. This meant that a significant number of samples were unsuitable for database searching. The advent of continuous methods for the interpretation of DNA profiles offers an advanced way to draw inferential power from the considerable investment made in DNA databases. Using these methods, each profile on the database may be considered a possible contributor to a mixture and a likelihood ratio (LR) can be formed. Those profiles which produce a sufficiently large LR can serve as an investigative lead. In this paper empirical studies are described to determine what constitutes a large LR. We investigate the effect on a database search of complex mixed DNA profiles with contributors in equal proportions with dropout as a consideration, and also the effect of an incorrect assignment of the number of contributors to a profile. In addition, we give, as a demonstration of the method, the results using two crime samples that were previously unsuitable for database comparison. We show that effective management of the selection of samples for searching and the interpretation of the output can be highly informative. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Modeling and clustering users with evolving profiles in usage streams

KAUST Repository

Zhang, Chongsheng; Masseglia, Florent; Zhang, Xiangliang

2012-01-01

Today, there is an increasing need of data stream mining technology to discover important patterns on the fly. Existing data stream models and algorithms commonly assume that users' records or profiles in data streams will not be updated or revised once they arrive. Nevertheless, in various applications such asWeb usage, the records/profiles of the users can evolve along time. This kind of streaming data evolves in two forms, the streaming of tuples or transactions as in the case of traditional data streams, and more importantly, the evolving of user records/profiles inside the streams. Such data streams bring difficulties on modeling and clustering for exploring users' behaviors. In this paper, we propose three models to summarize this kind of data streams, which are the batch model, the Evolving Objects (EO) model and the Dynamic Data Stream (DDS) model. Through creating, updating and deleting user profiles, these models summarize the behaviors of each user as a profile object. Based upon these models, clustering algorithms are employed to discover interesting user groups from the profile objects. We have evaluated all the proposed models on a large real-world data set, showing that the DDS model summarizes the data streams with evolving tuples more efficiently and effectively, and provides better basis for clustering users than the other two models. © 2012 IEEE.

Modeling and clustering users with evolving profiles in usage streams

KAUST Repository

Zhang, Chongsheng

2012-09-01

Today, there is an increasing need of data stream mining technology to discover important patterns on the fly. Existing data stream models and algorithms commonly assume that users\\' records or profiles in data streams will not be updated or revised once they arrive. Nevertheless, in various applications such asWeb usage, the records/profiles of the users can evolve along time. This kind of streaming data evolves in two forms, the streaming of tuples or transactions as in the case of traditional data streams, and more importantly, the evolving of user records/profiles inside the streams. Such data streams bring difficulties on modeling and clustering for exploring users\\' behaviors. In this paper, we propose three models to summarize this kind of data streams, which are the batch model, the Evolving Objects (EO) model and the Dynamic Data Stream (DDS) model. Through creating, updating and deleting user profiles, these models summarize the behaviors of each user as a profile object. Based upon these models, clustering algorithms are employed to discover interesting user groups from the profile objects. We have evaluated all the proposed models on a large real-world data set, showing that the DDS model summarizes the data streams with evolving tuples more efficiently and effectively, and provides better basis for clustering users than the other two models. © 2012 IEEE.

Profiles

International Nuclear Information System (INIS)

2004-01-01

Profiles is a synthetic overview of more than 100 national energy markets in the world, providing insightful facts and key energy statistics. A Profile is structured around 6 main items and completed by key statistics: Ministries, public agencies, energy policy are concerned; main companies in the oil, gas, electricity and coal sectors, status, shareholders; reserve, production, imports and exports, electricity and refining capacities; deregulation of prices, subsidies, taxes; consumption trends by sector, energy market shares; main energy projects, production and consumption prospects. Statistical Profiles are present in about 3 pages the main data and indicators on oil, gas, coal and electricity. (A.L.B.)

Ultra-shallow arsenic implant depth profiling using low-energy nitrogen beams

International Nuclear Information System (INIS)

Fearn, Sarah; Chater, Richard; McPhail, David

2004-01-01

Sputtering of silicon by low-energy nitrogen primary ion beams has been studied by a number of authors to characterize the altered layer, ripple formation and the sputtered yields of secondary ions [Surf. Sci. 424 (1999) 299; Appl. Phys. A: Mater. Sci. Process 53 (1991) 179; Appl. Phys. Lett. 73 (1998) 1287]. This study examines the application of low-energy nitrogen primary ion beams for the possible depth profiling of ultra-shallow arsenic implants into silicon. The emphasis of this work is on the matrix silicon signals in the pre-equilibrium surface region that are used for dose calibration. Problems with these aspects of the concentration depth profiling can give significant inconsistencies well outside the error limits of the quoted dose for the arsenic implantation as independently verified by CV profiling. This occurs during depth profiling with either oxygen primary ion beams (with and without oxygen leaks) or cesium primary ion beams

Neural network evaluation of tokamak current profiles for real time control

Science.gov (United States)

Wróblewski, Dariusz

1997-02-01

Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q0, minimum value of q, qmin, and the location of qmin. Very good performance of the trained neural network both for simulated test data and for experimental datais demonstrated.

Neural network evaluation of tokamak current profiles for real time control

International Nuclear Information System (INIS)

Wroblewski, D.

1997-01-01

Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q 0 , minimum value of q, q min , and the location of q min . Very good performance of the trained neural network both for simulated test data and for experimental datais demonstrated. copyright 1997 American Institute of Physics

Thermal Depth Profiling Reconstruction by Multilayer Thermal Quadrupole Modeling and Particle Swarm Optimization

International Nuclear Information System (INIS)

Zhao-Jiang, Chen; Shu-Yi, Zhang

2010-01-01

A new hybrid inversion method for depth profiling reconstruction of thermal conductivities of inhomogeneous solids is proposed based on multilayer quadrupole formalism of thermal waves, particle swarm optimization and sequential quadratic programming. The reconstruction simulations for several thermal conductivity profiles are performed to evaluate the applicability of the method. The numerical simulations demonstrate that the precision and insensitivity to noise of the inversion method are very satisfactory. (condensed matter: structure, mechanical and thermal properties)

From the chlorophyll a in the surface layer to its vertical profile: a Greenland Sea relationship for satellite applications

Directory of Open Access Journals (Sweden)

A. Cherkasheva

2013-04-01

Full Text Available Current estimates of global marine primary production range over a factor of two. Improving these estimates requires an accurate knowledge of the chlorophyll vertical profiles, since they are the basis for most primary production models. At high latitudes, the uncertainty in primary production estimates is larger than globally, because here phytoplankton absorption shows specific characteristics due to the low-light adaptation, and in situ data and ocean colour observations are scarce. To date, studies describing the typical chlorophyll profile based on the chlorophyll in the surface layer have not included the Arctic region, or, if it was included, the dependence of the profile shape on surface concentration was neglected. The goal of our study was to derive and describe the typical Greenland Sea chlorophyll profiles, categorized according to the chlorophyll concentration in the surface layer and further monthly resolved profiles. The Greenland Sea was chosen because it is known to be one of the most productive regions of the Arctic and is among the regions in the Arctic where most chlorophyll field data are available. Our database contained 1199 chlorophyll profiles from R/Vs Polarstern and Maria S. Merian cruises combined with data from the ARCSS-PP database (Arctic primary production in situ database for the years 1957–2010. The profiles were categorized according to their mean concentration in the surface layer, and then monthly median profiles within each category were calculated. The category with the surface layer chlorophyll (CHL exceeding 0.7 mg C m−3 showed values gradually decreasing from April to August. A similar seasonal pattern was observed when monthly profiles were averaged over all the surface CHL concentrations. The maxima of all chlorophyll profiles moved from the greater depths to the surface from spring to late summer respectively. The profiles with the smallest surface values always showed a subsurface chlorophyll

Profiling Oman education data using data mining approach

Science.gov (United States)

Alawi, Sultan Juma Sultan; Shaharanee, Izwan Nizal Mohd; Jamil, Jastini Mohd

2017-10-01

Nowadays, with a large amount of data generated by many application services in different learning fields has led to the new challenges in education field. Education portal is an important system that leads to a better development of education field. This research paper presents an innovative data mining techniques to understand and summarizes the information of Oman's education data generated from the Ministry of Education Oman "Educational Portal". This research embarks into performing student profiling of the Oman student database. This study utilized the k-means clustering technique to determine the students' profiles. An amount of 42484-student records from Sultanate of Oman has been extracted for this study. The findings of this study show the practicality of clustering technique to investigating student's profiles. Allowing for a better understanding of student's behavior and their academic performance. Oman Education Portal contain a large amounts of user activity and interaction data. Analyses of this large data can be meaningful for educator to improve the student performance level and recognize students who needed additional attention.

Marine Profiles for OGC Sensor Web Enablement Standards

Science.gov (United States)

Jirka, Simon

2016-04-01

The use of OGC Sensor Web Enablement (SWE) standards in oceanology is increasing. Several projects are developing SWE-based infrastructures to ease the sharing of marine sensor data. This work ranges from developments on sensor level to efforts addressing interoperability of data flows between observatories and organisations. The broad range of activities using SWE standards leads to a risk of diverging approaches how the SWE specifications are applied. Because the SWE standards are designed in a domain independent manner, they intentionally offer a high degree of flexibility enabling implementation across different domains and usage scenarios. At the same time this flexibility allows one to achieve similar goals in different ways. To avoid interoperability issues, an agreement is needed on how to apply SWE concepts and how to use vocabularies in a common way that will be shared by different projects, implementations, and users. To address this need, partners from several projects and initiatives (AODN, BRIDGES, envri+, EUROFLEETS/EUROFLEETS2, FixO3, FRAM, IOOS, Jerico/Jerico-Next, NeXOS, ODIP/ODIP II, RITMARE, SeaDataNet, SenseOcean, X-DOMES) have teamed up to develop marine profiles of OGC SWE standards that can serve as a common basis for developments in multiple projects and organisations. The following aspects will be especially considered: 1.) Provision of metadata: For discovering sensors/instruments as well as observation data, to facilitate the interpretation of observations, and to integrate instruments in sensor platforms, the provision of metadata is crucial. Thus, a marine profile of the OGC Sensor Model Language 2.0 (SensorML 2.0) will be developed allowing to provide metadata for different levels (e.g. observatory, instrument, and detector) and sensor types. The latter will enable metadata of a specific type to be automatically inherited by all devices/sensors of the same type. The application of further standards such as OGC PUCK will benefit from

Use of ground-based wind profiles in mesoscale forecasting

Science.gov (United States)

Schlatter, Thomas W.

1985-01-01

A brief review is presented of recent uses of ground-based wind profile data in mesoscale forecasting. Some of the applications are in real time, and some are after the fact. Not all of the work mentioned here has been published yet, but references are given wherever possible. As Gage and Balsley (1978) point out, sensitive Doppler radars have been used to examine tropospheric wind profiles since the 1970's. It was not until the early 1980's, however, that the potential contribution of these instruments to operational forecasting and numerical weather prediction became apparent. Profiler winds and radiosonde winds compare favorably, usually within a few m/s in speed and 10 degrees in direction (see Hogg et al., 1983), but the obvious advantage of the profiler is its frequent (hourly or more often) sampling of the same volume. The rawinsonde balloon is launched only twice a day and drifts with the wind. In this paper, I will: (1) mention two operational uses of data from a wind profiling system developed jointly by the Wave Propagation and Aeronomy Laboratories of NOAA; (2) describe a number of displays of these same data on a workstation for mesoscale forecasting developed by the Program for Regional Observing and Forecasting Services (PROFS); and (3) explain some interesting diagnostic calculations performed by meteorologists of the Wave Propagation Laboratory.

Karolinske psychodynamic profile (KAPP)

DEFF Research Database (Denmark)

Mathiesen, Birgit Bork; Søgaard, Ulf

2006-01-01

psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil......psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil...

Oil characteristics and fatty acid profile of seeds from three varieties ...

African Journals Online (AJOL)

Oil characteristics and fatty acid profile of seeds from three varieties of date palm ... of oils, as indicators of the quality and safety, and oxidative status of edible oils, ... industry, these data suggest that the potential applications of date seed oil for ...

ScholarLens: extracting competences from research publications for the automatic generation of semantic user profiles

Directory of Open Access Journals (Sweden)

Bahar Sateli

2017-07-01

Full Text Available Motivation Scientists increasingly rely on intelligent information systems to help them in their daily tasks, in particular for managing research objects, like publications or datasets. The relatively young research field of Semantic Publishing has been addressing the question how scientific applications can be improved through semantically rich representations of research objects, in order to facilitate their discovery and re-use. To complement the efforts in this area, we propose an automatic workflow to construct semantic user profiles of scholars, so that scholarly applications, like digital libraries or data repositories, can better understand their users’ interests, tasks, and competences, by incorporating these user profiles in their design. To make the user profiles sharable across applications, we propose to build them based on standard semantic web technologies, in particular the Resource Description Framework (RDF for representing user profiles and Linked Open Data (LOD sources for representing competence topics. To avoid the cold start problem, we suggest to automatically populate these profiles by analyzing the publications (co-authored by users, which we hypothesize reflect their research competences. Results We developed a novel approach, ScholarLens, which can automatically generate semantic user profiles for authors of scholarly literature. For modeling the competences of scholarly users and groups, we surveyed a number of existing linked open data vocabularies. In accordance with the LOD best practices, we propose an RDF Schema (RDFS based model for competence records that reuses existing vocabularies where appropriate. To automate the creation of semantic user profiles, we developed a complete, automated workflow that can generate semantic user profiles by analyzing full-text research articles through various natural language processing (NLP techniques. In our method, we start by processing a set of research articles for a

The impact of shape memory test on degradation profile of a bioresorbable polymer.

Science.gov (United States)

Musioł, Marta; Jurczyk, Sebastian; Kwiecień, Michał; Smola-Dmochowska, Anna; Domański, Marian; Janeczek, Henryk; Włodarczyk, Jakub; Klim, Magdalena; Rydz, Joanna; Kawalec, Michał; Sobota, Michał

2018-05-01

The semicrystalline poly(L-lactide) (PLLA) belongs to the materials with shape memory effect (SME) and as a bioresorbable and biocompatible polymer it have found many applications in medical and pharmaceutical field. Assessment of the SME impact on the polymer degradation profile plays crucial role in applications such as drug release systems or in regenerative medicine. Herein, the results of in vitro degradation studies of PLLA samples after SME full test cycle are presented. The samples were loaded and deformed in two manners: progressive and non-progressive. The performed experiments illustrate also influence of the material mechanical damages, caused e.g. during incorrect implantation of PLLA product, on hydrolytic degradation profile. Apparently, degradation profiles are significantly different for the material which was not subjected to the deformation and the deformed ones. The materials after deformation of 50% (in SME cycle) was characterized by non-reversible morphology changes. The effect was observed in deformed samples during the SME test which were carried out ten times. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Novel Index for Online Voltage Stability Assessment Based on Correlation Characteristic of Voltage Profiles

Directory of Open Access Journals (Sweden)

M. R. Aghamohammadi

2011-06-01

Full Text Available Abstract: Voltage instability is a major threat for security of power systems. Preserving voltage security margin at a certain limit is a vital requirement for today’s power systems. Assessment of voltage security margin is a challenging task demanding sophisticated indices. In this paper, for the purpose of on line voltage security assessment a new index based on the correlation characteristic of network voltage profile is proposed. Voltage profile comprising all bus voltages contains the effect of network structure, load-generation patterns and reactive power compensation on the system behaviour and voltage security margin. Therefore, the proposed index is capable to clearly reveal the effect of system characteristics and events on the voltage security margin. The most attractive feature for this index is its fast and easy calculation from synchronously measured voltage profile without any need to system modelling and simulation and without any dependency on network size. At any instant of system operation by merely measuring network voltage profile and no further simulation calculation this index could be evaluated with respect to a specific reference profile. The results show that the behaviour of this index with respect to the change in system security is independent of the selected reference profile. The simplicity and easy calculation make this index very suitable for on line application. The proposed approach has been demonstrated on IEEE 39 bus test system with promising results showing its effectiveness and applicability.

Input-profile-based software failure probability quantification for safety signal generation systems

International Nuclear Information System (INIS)

Kang, Hyun Gook; Lim, Ho Gon; Lee, Ho Jung; Kim, Man Cheol; Jang, Seung Cheol

2009-01-01

The approaches for software failure probability estimation are mainly based on the results of testing. Test cases represent the inputs, which are encountered in an actual use. The test inputs for the safety-critical application such as a reactor protection system (RPS) of a nuclear power plant are the inputs which cause the activation of protective action such as a reactor trip. A digital system treats inputs from instrumentation sensors as discrete digital values by using an analog-to-digital converter. Input profile must be determined in consideration of these characteristics for effective software failure probability quantification. Another important characteristic of software testing is that we do not have to repeat the test for the same input value since the software response is deterministic for each specific digital input. With these considerations, we propose an effective software testing method for quantifying the failure probability. As an example application, the input profile of the digital RPS is developed based on the typical plant data. The proposed method in this study is expected to provide a simple but realistic mean to quantify the software failure probability based on input profile and system dynamics.

Profile: Asian Americans

Science.gov (United States)

... and Data > Minority Population Profiles > Asian American Profile: Asian Americans Asian American Profile (Map of the US with the top 10 states displaying the largest Asian American population according to the Census Bureau) CA - ...

Implications of fin profiles on overall performance and weight reduction of a fin and tube heat exchanger

DEFF Research Database (Denmark)

Singh, Shobhana; Sørensen, Kim; Simonsen, Anders Schou

2017-01-01

Fin and tube heat exchangers are being used in several industrial applications by means of novel design and optimized performance. Improvements in geometric design may deliver energy efficient and cost-effective heat exchanger performance with reduced weight. In this paper, a systematic study...... on a cross-flow type fin and tube heat exchanger design for a waste heat recovery application is conducted. The geometric profile of the fin is characterized by a dimensionless design variable named aspect ratio which is parametrically varied to obtain different profiles. Two cases, case-I, and case......,000 using computational fluid dynamics. The numerical results obtained for the reference fin profile are verified with the experimental correlations. Dimensionless parameters such as Nusselt number, Euler number, and efficiency index are calculated to predict the overall performance of the heat exchanger...

Beam profile measurements using nonimaging gamma optics

International Nuclear Information System (INIS)

Norem, J.; Dawson, J.; Haberichter, W.; Lam, R.; Reed, L.; Yang, X.F.; Spencer, J.

1995-01-01

High energy photons produced from bremsstrahlung foils, Compton scattering or beamstrahlung from high energy e + e - collisions can be used to measure beam profiles using nonimaging optics. We describe the method and its limitations (resolution, backgrounds etc.), as well as the apparatus required to implement it. Data from a low energy test run is described as well as other possible applications, such as a 250+250 GeV linear collider and possible experiments with existing beams. (orig.)

Fourier Descriptor Analysis and Unification of Voice Range Profile Contours: Method and Applications

Science.gov (United States)

Pabon, Peter; Ternstrom, Sten; Lamarche, Anick

2011-01-01

Purpose: To describe a method for unified description, statistical modeling, and comparison of voice range profile (VRP) contours, even from diverse sources. Method: A morphologic modeling technique, which is based on Fourier descriptors (FDs), is applied to the VRP contour. The technique, which essentially involves resampling of the curve of the…

Techniques for obtaining velocity distributions of atoms or ions from Doppler-broadened spectral line profiles

International Nuclear Information System (INIS)

Moran, T.G.

1986-12-01

Analysis of the doppler-broadened profiles of spectral lines radiated by atoms or ions in plasmas yields information about their velocity distributions. Researchers have analysed profiles of lines radiated by atoms in isotropic velocity distributions in several ways, one being the inversion of the integral equation which relates the velocity distribution to the line profile. This inversion formula was derived for a separate application and was given to within an arbitrary multiplicative constant. This paper presents a new derivation which obtains the inversion exactly, using a method which is easily generalized for determination of anisotropic velocity distribution functions. The technique to obtain an anisotropic velocity distribution function from line profiles measured at different angles is outlined

MOBILE APPLICATIONS FOR TOURISM. STUDY REGARDING THEIR USE BY ROMANIANS

Directory of Open Access Journals (Sweden)

TUTUNEA MIHAELA FILOFTEIA

2016-08-01

Full Text Available The amazing development of the ICT industry and mobile technologies impressed a behavioural change and adaptation on individual and corporate users revealed at the level of current activities as well as in the consumer behaviours. Tourism industry has always been one of the most adaptable sectors, following the trends imposed by the two abovementioned industries. The increase in tourists’ mobility, users of mobile devices, also made necessary the adaptation of the distribution of tourism products and services and their redirecting towards the mobile environment. Taking into account these aspects, the present study was conceived on two levels. The first level identifies important aspects of mobile applications in general, by types and classifications, as well as presents a concise static image of them at global level. It also describes aspects related to mobile applications dedicated to tourism as offers to mobile device users. The second level comprises the study regarding the usage of tourism-specific mobile applications by Romanian mobile device users. The results of this study indicate the profile of the tourist-user of mobile devices from Romania, captured on three levels, namely: a socio-demographic profile, a mobility profile and a tourism-related mobile application user profile. We consider that these results provide useful information to companies belonging to the tourism and software industries, as well as indie developers of mobile applications, and users of mobile devices.

Development of a probe for inner profile measurement and flaw detection

Science.gov (United States)

Yoshizawa, Toru; Wakayama, Toshitaka; Kamakura, Yoshihisa

2011-08-01

It is one of the important necessities to precisely measure the inner diameter and/or the inner profile of pipes, tubes and other objects similar in shape. Especially in mechanical engineering field, there are many requests from automobile industry because the inner surface of engine blocks and other die casts are strongly required to be inspected and measured by non-contact methods (not by the naked eyes inspection using a borescope). If the inner diameter is large enough like water pipes or drain pipes, complicated and large equipment may be applicable. However, small pipes with a diameter ranging from 10mm to 100mm are difficult to be inspected by such a large instrument as is used for sewers inspection. And we have proposed an instrument which has no moving elements such as a rotating mirror or a prism for scanning a beam. Our measurement method is based on optical sectioning using triangulation. This optically sectioned profile of an inner wall of pipe-like objects is analyzed to produce numerical data of inner diameter or profile. Here, we report recent development of the principle and applications of the optical instrument with a simple and compact configuration. In addition to profile measurement, we found flaws and defects on the inner wall were also detected by using the similar principle. Up to now, we have developed probes with the diameter of 8mm to 25mm for small size objects and another probe (80 mm in diameter) for such a larger container with the dimensional size of 600mm.

Accurate, fully-automated NMR spectral profiling for metabolomics.

Directory of Open Access Journals (Sweden)

Siamak Ravanbakhsh

Full Text Available Many diseases cause significant changes to the concentrations of small molecules (a.k.a. metabolites that appear in a person's biofluids, which means such diseases can often be readily detected from a person's "metabolic profile"-i.e., the list of concentrations of those metabolites. This information can be extracted from a biofluids Nuclear Magnetic Resonance (NMR spectrum. However, due to its complexity, NMR spectral profiling has remained manual, resulting in slow, expensive and error-prone procedures that have hindered clinical and industrial adoption of metabolomics via NMR. This paper presents a system, BAYESIL, which can quickly, accurately, and autonomously produce a person's metabolic profile. Given a 1D 1H NMR spectrum of a complex biofluid (specifically serum or cerebrospinal fluid, BAYESIL can automatically determine the metabolic profile. This requires first performing several spectral processing steps, then matching the resulting spectrum against a reference compound library, which contains the "signatures" of each relevant metabolite. BAYESIL views spectral matching as an inference problem within a probabilistic graphical model that rapidly approximates the most probable metabolic profile. Our extensive studies on a diverse set of complex mixtures including real biological samples (serum and CSF, defined mixtures and realistic computer generated spectra; involving > 50 compounds, show that BAYESIL can autonomously find the concentration of NMR-detectable metabolites accurately (~ 90% correct identification and ~ 10% quantification error, in less than 5 minutes on a single CPU. These results demonstrate that BAYESIL is the first fully-automatic publicly-accessible system that provides quantitative NMR spectral profiling effectively-with an accuracy on these biofluids that meets or exceeds the performance of trained experts. We anticipate this tool will usher in high-throughput metabolomics and enable a wealth of new applications of

Bayesian mixture analysis for metagenomic community profiling.

Science.gov (United States)

Morfopoulou, Sofia; Plagnol, Vincent

2015-09-15

Deep sequencing of clinical samples is now an established tool for the detection of infectious pathogens, with direct medical applications. The large amount of data generated produces an opportunity to detect species even at very low levels, provided that computational tools can effectively profile the relevant metagenomic communities. Data interpretation is complicated by the fact that short sequencing reads can match multiple organisms and by the lack of completeness of existing databases, in particular for viral pathogens. Here we present metaMix, a Bayesian mixture model framework for resolving complex metagenomic mixtures. We show that the use of parallel Monte Carlo Markov chains for the exploration of the species space enables the identification of the set of species most likely to contribute to the mixture. We demonstrate the greater accuracy of metaMix compared with relevant methods, particularly for profiling complex communities consisting of several related species. We designed metaMix specifically for the analysis of deep transcriptome sequencing datasets, with a focus on viral pathogen detection; however, the principles are generally applicable to all types of metagenomic mixtures. metaMix is implemented as a user friendly R package, freely available on CRAN: http://cran.r-project.org/web/packages/metaMix sofia.morfopoulou.10@ucl.ac.uk Supplementary data are available at Bionformatics online. © The Author 2015. Published by Oxford University Press.

Application of the inverse estimation method of current distribution from magnetic fields using genetic algorithm to beam profile measurement

International Nuclear Information System (INIS)

Kishimoto, M.; Sakasai, K.; Ara, K.

1994-01-01

In this paper, the new type of non-invasive beam profile monitor for intense ion accelerator using high-temperature superconductor. We regard the inverse estimation problem of beam profile as the optimum allocation problem of the currents into the cross-section of the beam vacuum pipe and applied genetic algorithm to solve this optimization problem. And we carried out the computer simulation to verify the effectiveness of this inverse estimation method of beam profile. (author)

Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer

International Nuclear Information System (INIS)

O’Donnell, Patrick; Shieh, Felice; Wei, Wen; Lawrence, H Jeffrey; Wu, Lin; Schilling, Robert; Bloom, Kenneth; Maltzman, Warren; Anderson, Steven; Soviero, Stephen; Ferguson, Jane; Shyu, Johnny; Current, Robert; Rehage, Taraneh; Tsai, Julie; Christensen, Mari; Tran, Ha Bich; Chien, Sean Shih-Chang

2013-01-01

Epidermal growth factor receptor (EGFR) gene mutations identify patients with non-small cell lung cancer (NSCLC) who have a high likelihood of benefiting from treatment with anti-EGFR tyrosine kinase inhibitors. Sanger sequencing is widely used for mutation detection but can be technically challenging, resulting in longer turn-around-time, with limited sensitivity for low levels of mutations. This manuscript details the technical performance verification studies and external clinical reproducibility studies of the cobas EGFR Mutation Test, a rapid multiplex real-time PCR assay designed to detect 41 mutations in exons 18, 19, 20 and 21. The assay’s limit of detection was determined using 25 formalin-fixed paraffin-embedded tissue (FFPET)-derived and plasmid DNA blends. Assay performance for a panel of 201 specimens was compared against Sanger sequencing with resolution of discordant specimens by quantitative massively parallel pyrosequencing (MPP). Internal and external reproducibility was assessed using specimens tested in duplicate by different operators, using different reagent lots, instruments and at different sites. The effects on the performance of the cobas EGFR test of endogenous substances and nine therapeutic drugs were evaluated in ten FFPET specimens. Other tests included an evaluation of the effects of necrosis, micro-organisms and homologous DNA sequences on assay performance, and the inclusivity of the assay for less frequent mutations. A >95% hit rate was obtained in blends with >5% mutant alleles, as determined by MPP analysis, at a total DNA input of 150 ng. The overall percent agreement between Sanger sequencing and the cobas test was 96.7% (negative percent agreement 97.5%; positive percent agreement 95.8%). Assay repeatability was 98% when tested with two operators, instruments, and reagent lots. In the external reproducibility study, the agreement was > 99% across all sites, all operators and all reagent lots for 11/12 tumors tested. Test

Fitting the IRI F2-profile function to measured profiles

International Nuclear Information System (INIS)

Reinisch, B.W.; Huang Xueqin

1997-01-01

Comparison with profile data from ionosondes shows that the IRI bottomside F2-profiles can be improved by using better B0 and B1 parameters. The best parameters (in a least-squares sense) can be easily calculated in a numerical procedure from measured profiles presented as a sum of Chebyshev polynomials. 7 refs, 5 figs, 1 tab

Effectively identifying user profiles in network and host metrics

Science.gov (United States)

Murphy, John P.; Berk, Vincent H.; Gregorio-de Souza, Ian

2010-04-01

This work presents a collection of methods that is used to effectively identify users of computers systems based on their particular usage of the software and the network. Not only are we able to identify individual computer users by their behavioral patterns, we are also able to detect significant deviations in their typical computer usage over time, or compared to a group of their peers. For instance, most people have a small, and relatively unique selection of regularly visited websites, certain email services, daily work hours, and typical preferred applications for mandated tasks. We argue that these habitual patterns are sufficiently specific to identify fully anonymized network users. We demonstrate that with only a modest data collection capability, profiles of individual computer users can be constructed so as to uniquely identify a profiled user from among their peers. As time progresses and habits or circumstances change, the methods presented update each profile so that changes in user behavior can be reliably detected over both abrupt and gradual time frames, without losing the ability to identify the profiled user. The primary benefit of our methodology allows one to efficiently detect deviant behaviors, such as subverted user accounts, or organizational policy violations. Thanks to the relative robustness, these techniques can be used in scenarios with very diverse data collection capabilities, and data privacy requirements. In addition to behavioral change detection, the generated profiles can also be compared against pre-defined examples of known adversarial patterns.

Neural network evaluation of tokamak current profiles for real time control (abstract)

Science.gov (United States)

Wróblewski, Dariusz

1997-01-01

Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q0, minimum value of q, qmin, and the location of qmin. Very good performance of the trained neural network both for simulated test data and for experimental data is demonstrated.

Neural network evaluation of tokamak current profiles for real time control (abstract)

International Nuclear Information System (INIS)

Wroblewski, D.

1997-01-01

Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q 0 , minimum value of q, q min , and the location of q min . Very good performance of the trained neural network both for simulated test data and for experimental data is demonstrated. copyright 1997 American Institute of Physics

Control-oriented modeling of the plasma particle density in tokamaks and application to real-time density profile reconstruction

NARCIS (Netherlands)

Blanken, T.C.; Felici, F.; Rapson, C.J.; de Baar, M.R.; Heemels, W.P.M.H.

2018-01-01

A model-based approach to real-time reconstruction of the particle density profile in tokamak plasmas is presented, based on a dynamic state estimator. Traditionally, the density profile is reconstructed in real-time by solving an ill-conditioned inversion problem using a measurement at a single

Disintegration of a profiled shock wave at the cumulation point

International Nuclear Information System (INIS)

Kaliski, S.

1978-01-01

The disintegration at the cumulation point is analyzed of a shock wave generated with the aid of a profiled pressure. The quantitative relations are analyzed for the disintegration waves for typical compression parameters in systems of thermonuclear microfusion. The quantitative conclusions are drawn for the application of simplifying approximate calculations in problems of microfusion. (author)

Ultrasonic velocity profiling rheometry based on a widened circular Couette flow

International Nuclear Information System (INIS)

Shiratori, Takahisa; Tasaka, Yuji; Oishi, Yoshihiko; Murai, Yuichi

2015-01-01

We propose a new rheometry for characterizing the rheological properties of fluids. The technique produces flow curves, which represent the relationship between the fluid shear rate and shear stress. Flow curves are obtained by measuring the circumferential velocity distribution of tested fluids in a circular Couette system, using an ultrasonic velocity profiling technique. By adopting a widened gap of concentric cylinders, a designed range of the shear rate is obtained so that velocity profile measurement along a single line directly acquires flow curves. To reduce the effect of ultrasonic noise on resultant flow curves, several fitting functions and variable transforms are examined to best approximate the velocity profile without introducing a priori rheological models. Silicone oil, polyacrylamide solution, and yogurt were used to evaluate the applicability of this technique. These substances are purposely targeted as examples of Newtonian fluids, shear thinning fluids, and opaque fluids with unknown rheological properties, respectively. We find that fourth-order Chebyshev polynomials provide the most accurate representation of flow curves in the context of model-free rheometry enabled by ultrasonic velocity profiling. (paper)

A power function profile of a ski jumping in-run hill.

Science.gov (United States)

Zanevskyy, Ihor

2011-01-01

The aim of the research was to find a function of the curvilinear segment profile which could make possible to avoid an instantaneous increasing of a curvature and to replace a circle arc segment on the in-run of a ski jump without any correction of the angles of inclination and the length of the straight-line segments. The methods of analytical geometry and trigonometry were used to calculate an optimal in-run hill profile. There were two fundamental conditions of the model: smooth borders between a curvilinear segment and straight-line segments of an in-run hill and concave of the curvilinear segment. Within the framework of this model, the problem has been solved with a reasonable precision. Four functions of a curvilinear segment profile of the in-run hill were investigated: circle arc, inclined quadratic parabola, inclined cubic parabola, and power function. The application of a power function to the in-run profile satisfies equal conditions for replacing a circle arc segment. Geometrical parameters of 38 modern ski jumps were investigated using the methods proposed.

49 CFR 399.203 - Applicability.

Science.gov (United States)

2010-10-01

... STANDARDS Step, Handhold, and Deck Requirements for Commercial Motor Vehicles § 399.203 Applicability. This subpart applies to all trucks and truck-tractors, having a high profile cab-over-engine (COE...

Non destructive method of determination of depth profiling with ESCA spectroscopy by angular distribution

International Nuclear Information System (INIS)

Pijolat, Michele.

1979-07-01

The aim of this study has been to determine the possibilities of photoelectron spectroscopy ESCA for depth profiling in the first hundred angstrom of a compound. First of all, the technique ESCA has been described in an analytical point of view. Then, the common sputter profiling method has been tested, and a model to deduce the concentrations profile has been formulated. However the analysis of the various effects due to the sputtering events showed that this method is able to give only the profile shape with a bad depth resolution. A new non destructive method based on the analysed depth dependence with photoelectrons emission angle is settled. A computational method (simplexe optimization) is used to deduce the concentrations profile. Simulation have revealed the necessity of submitting constraints proper to the system physical properties and allowed to state the applicability range of the method. The interface profiles Ag-Pd, Ag-Al 2 O 3 and SiO 2 -Si have been measured, and the surface segregation in CuNi alloy has been studied [fr

Pesticide Applicator Profiling: Using Polycom[R] Distance Delivery for Continuing Education and Characterizing Florida's Licensed Applicators

Science.gov (United States)

Fishel, Fred; Langeland, Ken

2011-01-01

The University of Florida offers continuing education units (CEUs) via distance technology using Polycom[R] to meet requirements for applicators of pesticides to renew their licenses. A large statewide event conducted in 2010 also included a needs assessment of this group concerning CEUs. Results indicate that these applicators strongly prefer…

Exact boundary controllability of nodal profile for quasilinear hyperbolic systems

CERN Document Server

Li, Tatsien; Gu, Qilong

2016-01-01

This book provides a comprehensive overview of the exact boundary controllability of nodal profile, a new kind of exact boundary controllability stimulated by some practical applications. This kind of controllability is useful in practice as it does not require any precisely given final state to be attained at a suitable time t=T by means of boundary controls, instead it requires the state to exactly fit any given demand (profile) on one or more nodes after a suitable time t=T by means of boundary controls. In this book we present a general discussion of this kind of controllability for general 1-D first order quasilinear hyperbolic systems and for general 1-D quasilinear wave equations on an interval as well as on a tree-like network using a modular-structure construtive method, suggested in LI Tatsien's monograph "Controllability and Observability for Quasilinear Hyperbolic Systems"(2010), and we establish a complete theory on the local exact boundary controllability of nodal profile for 1-D quasilinear hyp...

Whole-body profile scanner for in vivo quantitative activity measurement

International Nuclear Information System (INIS)

Bergmann, H.

1978-01-01

A whole-body profile scanner has been developed by fitting parallel slit collimators to a shadow shield whole-body counter. Sensitivity, uniformity and resolution measurements were performed using a number of different counting conditions. It is shown that improved accuracy of activity measurements is obtained by using a wide window counting technique for low and medium energy gamma emitters (99m Tc, 131 I), whereas a photopeak window should be used for high energy gamma emitters (47 Ca). Due to the finite spatial resolution of the system a systematic error in evaluating regional activities from the counting rate profile occurs which is characterized by a spatial spillover factor. The spatial spillover factor is measured and is subsequently used to calculate the error on basis of a simple model. It is shown that only small errors are caused by spatial spillover when the length of a region is at least three times the full width half maximum of the point spread function. Applying the above mentioned simple rules it is concluded that profile scanning is a sensitive and accurate technique for activity measurements in vivo. Two examples of clinical applications (measurement of bone accretion rates of calcium and Tc-pyrophosphate, regional radioiodine retention in patients with thyroid carcinoma) and a review of the papers on profile scanning demonstrate the types of investigations in which profile scanning is superior to alternative techniques. (author)

TEMPS-A[P] temperament profile related to professional choice. Differences between applicants to become a cadet officer in the Italian Air Force or Navy.

Science.gov (United States)

Rovai, Luca; Maremmani, Angelo Giovanni Icro; Leonardi, Annalisa; Bacciardi, Silvia; Rugani, Fabio; Dell'Osso, Liliana; Akiskal, Hagop S; Maremmani, Icro

2013-02-15

Temperament appears to be a factor involved in professional attitudes. The most impressive findings are those on the importance of cyclothymia in art and of hyperthymia in leadership. In this study we raise the issue of whether the relationship between hyperthymic temperament and the choice of a military career, previously reported among Italian Air Force applicants, can be extended to another military service such as the Italian Navy. We compared temperaments between those who had applied to become a cadet officer in the Italian Air Force or in the Italian Navy, with special reference to gender differences and the ability of the two types of applicants to pass the psychiatric examination for admission that we had recently assessed in the Italian Air Force. Hyperthymic traits were well represented in both these armed services. Navy applicants differed from air-force applicants in obtaining higher depressive, cyclothymic and irritable scores. Navy applicants who passed the psychiatric entrance examination (PEE) showed the same incidence of hyperthymic temperament as their Air Force counterparts, but higher depressive, cyclothymic and irritable scores. Considering gender, among Air Force applicants depressive traits were better represented in males; conversely, among Navy applicants they were better represented in females. If we consider gender together with PEE results, the highest hyperthymic scores were more frequently found among males who passed and females who failed to pass the PEE. On the other hand, a greater number of cyclothymic traits were found in females who passed and males who failed to pass the PEE. It was confirmed that hyperthymic temperament represents the temperamental profile of those who aim to become a cadet officer in the Italian armed forces. This study further supports the idea that hyperthymic traits bring distinct advantages in a professional field, such as a military career, which is closely related to leadership. Copyright © 2012

On the Anonymity Risk of Time-Varying User Profiles

Directory of Open Access Journals (Sweden)

Silvia Puglisi

2017-04-01

Full Text Available Websites and applications use personalisation services to profile their users, collect their patterns and activities and eventually use this data to provide tailored suggestions. User preferences and social interactions are therefore aggregated and analysed. Every time a user publishes a new post or creates a link with another entity, either another user, or some online resource, new information is added to the user profile. Exposing private data does not only reveal information about single users’ preferences, increasing their privacy risk, but can expose more about their network that single actors intended. This mechanism is self-evident in social networks where users receive suggestions based on their friends’ activities. We propose an information-theoretic approach to measure the differential update of the anonymity risk of time-varying user profiles. This expresses how privacy is affected when new content is posted and how much third-party services get to know about the users when a new activity is shared. We use actual Facebook data to show how our model can be applied to a real-world scenario.

Recommendations for processing atmospheric attenuated backscatter profiles from Vaisala CL31 ceilometers

Science.gov (United States)

Kotthaus, Simone; O'Connor, Ewan; Münkel, Christoph; Charlton-Perez, Cristina; Haeffelin, Martial; Gabey, Andrew M.; Grimmond, C. Sue B.

2016-08-01

Ceilometer lidars are used for cloud base height detection, to probe aerosol layers in the atmosphere (e.g. detection of elevated layers of Saharan dust or volcanic ash), and to examine boundary layer dynamics. Sensor optics and acquisition algorithms can strongly influence the observed attenuated backscatter profiles; therefore, physical interpretation of the profiles requires careful application of corrections. This study addresses the widely deployed Vaisala CL31 ceilometer. Attenuated backscatter profiles are studied to evaluate the impact of both the hardware generation and firmware version. In response to this work and discussion within the CL31/TOPROF user community (TOPROF, European COST Action aiming to harmonise ground-based remote sensing networks across Europe), Vaisala released new firmware (versions 1.72 and 2.03) for the CL31 sensors. These firmware versions are tested against previous versions, showing that several artificial features introduced by the data processing have been removed. Hence, it is recommended to use this recent firmware for analysing attenuated backscatter profiles. To allow for consistent processing of historic data, correction procedures have been developed that account for artefacts detected in data collected with older firmware. Furthermore, a procedure is proposed to determine and account for the instrument-related background signal from electronic and optical components. This is necessary for using attenuated backscatter observations from any CL31 ceilometer. Recommendations are made for the processing of attenuated backscatter observed with Vaisala CL31 sensors, including the estimation of noise which is not provided in the standard CL31 output. After taking these aspects into account, attenuated backscatter profiles from Vaisala CL31 ceilometers are considered capable of providing valuable information for a range of applications including atmospheric boundary layer studies, detection of elevated aerosol layers, and model

Functional protease profiling for diagnosis of malignant disease.

Science.gov (United States)

Findeisen, Peter; Neumaier, Michael

2012-01-01

Clinical proteomic profiling by mass spectrometry (MS) aims at uncovering specific alterations within mass profiles of clinical specimens that are of diagnostic value for the detection and classification of various diseases including cancer. However, despite substantial progress in the field, the clinical proteomic profiling approaches have not matured into routine diagnostic applications so far. Their limitations are mainly related to high-abundance proteins and their complex processing by a multitude of endogenous proteases thus making rigorous standardization difficult. MS is biased towards the detection of low-molecular-weight peptides. Specifically, in serum specimens, the particular fragments of proteolytically degraded proteins are amenable to MS analysis. Proteases are known to be involved in tumour progression and tumour-specific proteases are released into the blood stream presumably as a result of invasive progression and metastasis. Thus, the determination of protease activity in clinical specimens from patients with malignant disease can offer diagnostic and also therapeutic options. The identification of specific substrates for tumour proteases in complex biological samples is challenging, but proteomic screens for proteases/substrate interactions are currently experiencing impressive progress. Such proteomic screens include peptide-based libraries, differential isotope labelling in combination with MS, quantitative degradomic analysis of proteolytically generated neo-N-termini, monitoring the degradation of exogenous reporter peptides with MS, and activity-based protein profiling. In the present article, we summarize and discuss the current status of proteomic techniques to identify tumour-specific protease-substrate interactions for functional protease profiling. Thereby, we focus on the potential diagnostic use of the respective approaches. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Applications of Fourier analysis to broadening of stellar line profiles. V

International Nuclear Information System (INIS)

Smith, M.A.; Frisch, H.

1976-01-01

Turbulence dominated by eddies of a finite size produces effects on a line profile which are similar to both macro- and micro-turbulence but which are at the same time neither. It is suggested that one of these effects in the Fourier transform domain, namely the narrowing of the first natural sidelobe relative to the width of the main lobe, can be used as an indicator of the dominance of finite-sized eddies ('mesoturbulence'). An examination of some existing solar data shows that finite-sized eddy models fit the observed sidelobe widths better than do models computed with any reasonable combination of micro- and macro-turbulent broadenings. (Auth.)

YOUNG ATHLETES' MOTIVATIONAL PROFILES

Directory of Open Access Journals (Sweden)

Juan Antonio Moreno Murcia

2007-06-01

Full Text Available The aim of this study was to examine the relationship between motivational characteristics and dispositional flow. In order to accomplish this goal, motivational profiles emerging from key constructs within Achievement Goal Theory and Self-Determination Theory were related to the dispositional flow measures. A sample of 413 young athletes (Age range 12 to 16 years completed the PMCSQ-2, POSQ, SMS and DFS measures. Cluster analysis results revealed three profiles: a "self-determined profile" characterised by higher scores on the task-involving climate perception and on the task orientation; a "non-self-determined profile", characterised by higher scores on ego-involving climate perception and ego orientation; and a "low self-determined and low non-self-determined profile" which had the lowest dispositional flow. No meaningful differences were found between the "self-determined profile" and the "non-self-determined profile" in dispositional flow. The "self-determined profile" was more commonly associated with females, athletes practising individual sports and those training more than three days a week. The "non-self-determined profile" was more customary of males and athletes practising team sports as well as those training just two or three days a week

SURFACE BRIGHTNESS PROFILES OF DWARF GALAXIES. I. PROFILES AND STATISTICS

International Nuclear Information System (INIS)

Herrmann, Kimberly A.; Hunter, Deidre A.; Elmegreen, Bruce G.

2013-01-01

Radial surface brightness profiles of spiral galaxies are classified into three types: (I) single exponential, or the light falls off with one exponential to a break before falling off (II) more steeply, or (III) less steeply. Profile breaks are also found in dwarf disks, but some dwarf Type IIs are flat or increasing out to a break before falling off. Here we re-examine the stellar disk profiles of 141 dwarfs: 96 dwarf irregulars (dIms), 26 Blue Compact Dwarfs (BCDs), and 19 Magellanic-type spirals (Sms). We fit single, double, or even triple exponential profiles in up to 11 passbands: GALEX FUV and NUV, ground-based UBVJHK and Hα, and Spitzer 3.6 and 4.5 μm. We find that more luminous galaxies have brighter centers, larger inner and outer scale lengths, and breaks at larger radii; dwarf trends with M B extend to spirals. However, the V-band break surface brightness is independent of break type, M B , and Hubble type. Dwarf Type II and III profiles fall off similarly beyond the breaks but have different interiors and IIs break ∼twice as far as IIIs. Outer Type II and III scale lengths may have weak trends with wavelength, but pure Type II inner scale lengths clearly decrease from the FUV to visible bands whereas Type III inner scale lengths increase with redder bands. This suggests the influence of different star formation histories on profile type, but nonetheless the break location is approximately the same in all passbands. Dwarfs continue trends between profile and Hubble types such that later-type galaxies have more Type II but fewer Type I and III profiles than early-type spirals. BCDs and Sms are over-represented as Types III and II, respectively, compared to dIms

Pulsed glow discharge mass spectrometry for molecular depth profiling of polymers

International Nuclear Information System (INIS)

Lobo, L.; Pereiro, R.; Sanz-Medel, A.; Bordel, N.; Pisonero, J.; Licciardello, A.; Tuccitto, N.; Tempez, A.; Chapon, P.

2009-01-01

Full text: Nowadays thin films of polymeric materials involve a wide range of industrial applications, so techniques capable of providing in-depth profile information are required. Most of the techniques available for this purpose are based on the use of energetic particle beams which interact with polymers producing undesirable physicochemical modifications. Radiofrequency pulsed glow discharge (rf-pulsed-GD) coupled to time-of-flight mass spectrometry (TOFMS) could afford the possibility of acquiring both elemental and molecular information creating minimal damage to surfaces and thereby obtaining depth profiles. This work will evaluate rf-GDs coupled to an orthogonal TOFMS for direct analysis of polymers. (author)

A brief history of the development of wind-profiling or MST radars

Directory of Open Access Journals (Sweden)

T. E. Van Zandt

2000-07-01

Full Text Available The history of the development of the wind-profiling or MST radar technique is reviewed from its inception in the late 1960s to the present. Extensions of the technique by the development of boundary-layer radars and the radio-acoustic sounding system (RASS technique to measure temperature are documented. Applications are described briefly, particularly practical applications to weather forecasting, with data from networks of radars, and scientific applications to the study of rapidly varying atmospheric phenomena such as gravity waves and turbulence.Key words: Meteorology and atmospheric dynamics (instruments and techniques · Radio science (remote sensing; instruments and techniques

Element depth profiles of porous silicon

International Nuclear Information System (INIS)

Kobzev, A.P.; Nikonov, O.A.; Kulik, M.; Zuk, J.; Krzyzanowska, H.; Ochalski, T.J.

1997-01-01

Element depth profiles of porous silicon were measured on the Van-de-Graaff accelerator in the energy range of 4 He + ions from 2 to 3.2 MeV. Application of complementary RBS, ERD and 16 O(α,α) 16 O nuclear reaction methods permits us to obtain: 1) the exact silicon, oxygen and hydrogen distribution in the samples, 2) the distribution of partial pore concentrations. The oxygen concentration in porous silicon reaches 30%, which allows one to assume the presence of silicon oxide in the pores and to explain the spectrum shift of luminescence into the blue area

Internet profiling: The economy of data intraoperability on Facebook and Google

Directory of Open Access Journals (Sweden)

Anja Bechmann

2013-10-01

Full Text Available This article investigates online profiling and data strategies by identifying and comparing data strategies of the two most visited internet companies, Google and Face- book. The aim of the article is to use media economics and management perspectives to enrich the discussion on profiling from a political economy perspective. The article maps differences in the data strategies of the services and the potential data collected through a data point analysis, and suggests conceptual distinctions between vertical and horizontal data strategies, touch point and social network, integrated and diversified application programming interface (API structures, and relevance and reputation data strategy perspectives. Furthermore, the findings in the article suggest distinguishing among profiling for advertisers, developers, and government agencies. Addressing these stakeholders through the identified data strategic differences, the findings point to different implications for privacy, digital divides, algorithmic adoption, and societal segregation and intolerance.  

Internet profiling: The economy of data intraoperability on Facebook and Google

Directory of Open Access Journals (Sweden)

Anja Bechmann

2013-12-01

Full Text Available This article investigates online profiling and data strategies by identifying and comparing data strategies of the two most visited internet companies, Google and Face- book. The aim of the article is to use media economics and management perspectives to enrich the discussion on profiling from a political economy perspective. The article maps differences in the data strategies of the services and the potential data collected through a data point analysis, and suggests conceptual distinctions between vertical and horizontal data strategies, touch point and social network, integrated and diversified application programming interface (API structures, and relevance and reputation data strategy perspectives. Furthermore, the findings in the article suggest distinguishing among profiling for advertisers, developers, and government agencies. Addressing these stakeholders through the identified data strategic differences, the findings point to different implications for privacy, digital divides, algorithmic adoption, and societal segregation and intolerance.

The Potential of Cosmetic Applicators as a Source of DNA for Forensic Analysis.

Science.gov (United States)

Adamowicz, Michael S; Labonte, Renáe D; Schienman, John E

2015-07-01

Personal products, such as toothbrushes, have been used as both known reference and evidentiary samples for forensic DNA analysis. This study examined the viability of a broad selection of cosmetic applicators for use as targets for human DNA extraction and short tandem repeat (STR) analysis using standard polymerase chain reaction (PCR) conditions. Applicator types included eyeliner smudgers, pencils and crayons, eye shadow sponges, mascara wands, concealer wands, face makeup sponges, pads and brushes, lipsticks and balms, and lip gloss wands. The quantity and quality of DNA extracted from each type of applicator were examined by assessing the number of loci successfully amplified and the peak balance of the heterozygous alleles in each full STR profile. While degraded DNA, stochastic amplification, and PCR inhibition were observed for some items, full STR profiles were developed for 14 of 76 applicators. The face makeup sponge applicators yielded the highest proportional number of full STR profiles (4/7). © 2015 American Academy of Forensic Sciences.

Reliability Assessment of Transformerless PV Inverters Considering Mission Profiles

DEFF Research Database (Denmark)

Yang, Yongheng; Wang, Huai; Blaabjerg, Frede

2015-01-01

reliability of three transformerless inverters under a yearly mission profile (i.e., solar irradiance and ambient temperature). The mission profile is translated to device thermal loading, which is used for lifetime prediction. Compar¬ison results reveal the lifetime mismatches among the power switching......Due to the small volume and high efficiency, transformerless inverters have gained much popularity in grid-connected PV applications, where minimizing leakage current injection is mandatory. This can be achieved either by modifying the modulation schemes or adding extra power switching devices......, resulting in an uneven distribution of the power losses on the switching devices. Consequently, the device thermal loading is redis-tributed, and thus may alter the entire inverter reliability performance, especially under a long-term operation. In this consideration, this paper assesses the device...

Employing Beam-Gas Interaction Vertices for Transverse Profile Measurements

CERN Document Server

Rihl, Mariana; Baglin, Vincent; Barschel, Colin; Bay, Aurelio; Blanc, Frederic; Bravin, Enrico; Bregliozzi, Giuseppe; Chritin, Nicolas; Dehning, Bernd; Ferro-Luzzi, Massimiliano; Gaspar, Clara; Gianì, Sebastiana; Giovannozzi, Massimo; Greim, Roman; Haefeli, Guido; Hopchev, Plamen; Jacobsson, Richard; Jensen, Lars; Jones, Owain Rhodri; Jurado, Nicolas; Kain, Verena; Karpinski, Waclaw; Kirn, Thomas; Kuhn, Maria; Luthi, Berengere; Magagnin, Paolo; Matev, Rosen; Nakada, Tatsuya; Neufeld, Niko; Panman, Jaap; Rakotomiaramanana, Barinjaka; Salustino Guimaraes, Valdir; Salvant, Benoit; Schael, Stefan; Schneider, Olivier; Schwering, Georg; Tobin, Mark; Veness, Raymond; Veyrat, Quentin; Vlachos, Sotiris; Wlochal, Michael; Xu, Zhirui; von Dratzig, Arndt

2016-01-01

Interactions of high-energy beam particles with residual gas offer a unique opportunity to measure the beam profile in a non-intrusive fashion. Such a method was successfully pioneered* at the LHCb experiment using a silicon microstrip vertex detector. During the recent Large Hadron Collider shutdown at CERN, a demonstrator Beam-Gas Vertexing system based on eight scintillating-fibre modules was designed**, constructed and installed on Ring 2 to be operated as a pure beam diagnostics device. The detector signals are read out and collected with LHCb-type front-end electronics and a DAQ system consisting of a CPU farm. Tracks and vertices will be reconstructed to obtain a beam profile in real time. Here, first commissioning results are reported. The advantages and potential for future applications of this technique are discussed.

A Parametric Model for Barred Equilibrium Beach Profiles

Science.gov (United States)

2014-05-10

to shallow water. Bodge (1992) and Komar and McDougal (1994) suggested an exponential form as a preferred solution that exhibited finite slope at the...performance measures were computed from the shoreline to hsea, the active volume of sand bar variability. 3.1. Duck, NC, example Tests were carried out...applications. J. Coast. Res. 7, 53–84. Komar, P.D., McDougal ,W.G., 1994. The analysis of beach profiles and nearshore processes using the exponential beach

Fitness on facebook: advertisements generated in response to profile content.

Science.gov (United States)

Villiard, Hope; Moreno, Megan A

2012-10-01

Obesity is a challenging problem affecting almost half of college students. To solve this complex health problem, innovative approaches must be utilized. Over 94 percent of college students maintain a Facebook profile, providing them a venue to publicly disclose current fitness behaviors. Displayed advertisements on Facebook are tailored to profile content and may influence college students' fitness efforts. Facebook may be an innovative venue for improving college students' fitness behaviors. The purpose of this project was to determine (a) how and to what extent college students are discussing fitness on Facebook, and (b) how user-generated fitness information is linked to advertisements for fitness products and advice. First, public Facebook profiles of individual college students were evaluated for displayed fitness references based on 10 fitness behavior categories. Inter-rator reliability between two coders was 91.18 percent. Second, 10 fitness status updates were generated and posted by a researcher on a Facebook profile; the first 40 linked advertisements to these statements were examined. Advertisements were categorized and then examined for relevance to the college population. A total of 57 individual profiles were examined; owners had an average age of 18.3 years (SD=0.51), and 36.8 percent were women. About 71.9 percent of profiles referenced one or more fitness behavior; 97.6 percent referenced exercise, 4.9 percent dieting, and 4.9 percent unhealthy eating. Among the first 40 ads linked to generated status updates, 40.3 percent were fitness related. Most advertisements were for charity runs (30.4 percent), fitness apparel (24.2 percent), or fad diets (9.9 percent). Students referred both healthy and unhealthy fitness behaviors on their Facebook profiles, and these trigger the display of fitness-related advertisements of which few appear applicable. A community- or university-based intervention could be designed and implemented to provide relevant and

[An international neuropsychological assessment tool for children, adolescents, and adults with anorexia nervosa – the German adaptation of the Ravello Profile].

Science.gov (United States)

van Noort, Betteke Maria; Pfeiffer, Ernst; Lehmkuhl, Ulrike; Kappel, Viola

2013-11-01

Adults with anorexia nervosa (AN) show weaknesses in several cognitive functions before and after weight restoration. There is a great demand for standardized examinations of executive functioning in the field of child and adolescent AN. Previous studies exhibited methodological inconsistencies regarding test selection and operationalization of cognitive functions, making the interpretation of their findings difficult. In order to overcome these inconsistencies, a neuropsychological assessment tool, the "Ravello Profile," was developed, though previously not available in German. This paper presents a German adaptation of the Ravello Profile and illustrates its applicability in children and adolescents via three case descriptions. The Ravello Profile was adapted for the German-speaking area. The applicability of the Ravello Profile was evaluated in three children and adolescents with AN. The cases presented confirm the feasible implementation of this adaptation of the Ravello Profile, both in children and adolescents. Hence, it enables a methodologically consistent examination of executive functioning in German-speaking children, adolescents, and adults with AN. Using the Ravello Profile, the role of cognitive functions in the development of AN can be systematically examined over a broad age range.

Tractable flux-driven temperature, density, and rotation profile evolution with the quasilinear gyrokinetic transport model QuaLiKiz

Science.gov (United States)

Citrin, J.; Bourdelle, C.; Casson, F. J.; Angioni, C.; Bonanomi, N.; Camenen, Y.; Garbet, X.; Garzotti, L.; Görler, T.; Gürcan, O.; Koechl, F.; Imbeaux, F.; Linder, O.; van de Plassche, K.; Strand, P.; Szepesi, G.; Contributors, JET

2017-12-01

Quasilinear turbulent transport models are a successful tool for prediction of core tokamak plasma profiles in many regimes. Their success hinges on the reproduction of local nonlinear gyrokinetic fluxes. We focus on significant progress in the quasilinear gyrokinetic transport model QuaLiKiz (Bourdelle et al 2016 Plasma Phys. Control. Fusion 58 014036), which employs an approximated solution of the mode structures to significantly speed up computation time compared to full linear gyrokinetic solvers. Optimisation of the dispersion relation solution algorithm within integrated modelling applications leads to flux calculations × {10}6-7 faster than local nonlinear simulations. This allows tractable simulation of flux-driven dynamic profile evolution including all transport channels: ion and electron heat, main particles, impurities, and momentum. Furthermore, QuaLiKiz now includes the impact of rotation and temperature anisotropy induced poloidal asymmetry on heavy impurity transport, important for W-transport applications. Application within the JETTO integrated modelling code results in 1 s of JET plasma simulation within 10 h using 10 CPUs. Simultaneous predictions of core density, temperature, and toroidal rotation profiles for both JET hybrid and baseline experiments are presented, covering both ion and electron turbulence scales. The simulations are successfully compared to measured profiles, with agreement mostly in the 5%-25% range according to standard figures of merit. QuaLiKiz is now open source and available at www.qualikiz.com.

Mass spectrometry based proteomics profiling as diagnostic tool in oncology: current status and future perspective.

Science.gov (United States)

Findeisen, Peter; Neumaier, Michael

2009-01-01

Proteomics analysis has been heralded as a novel tool for identifying new and specific biomarkers that may improve diagnosis and monitoring of various disease states. Recent years have brought a number of proteomics profiling technologies. Although proteomics profiling has resulted in the detection of disease-associated differences and modification of proteins, current proteomics technologies display certain limitations that are hampering the introduction of these new technologies into clinical laboratory diagnostics and routine applications. In this review, we summarize current advances in mass spectrometry based biomarker discovery. The promises and challenges of this new technology are discussed with particular emphasis on diagnostic perspectives of mass-spectrometry based proteomics profiling for malignant diseases.

Ground-Based Remote or In Situ Measurement of Vertical Profiles of Wind in the Lower Troposphere

Energy Technology Data Exchange (ETDEWEB)

Clifton, Andrew; Newman, Jennifer

2017-02-24

Knowledge of winds in the lower troposphere is essential for a range of applications, including weather forecasting, transportation, natural hazards, and wind energy. This presentation focuses on the measurement of vertical profiles of wind in the lower troposphere for wind energy applications. This presentation introduces the information that wind energy site development and operations require, how it used, and the benefits and problems of current measurements from in-situ measurements and remote sensing. The development of commercial Doppler wind lidar systems over the last 10 years are shown, along with the lessons learned from this experience. Finally, potential developments in wind profiling aimed at reducing uncertainty and increasing data availability are introduced.

ERM 593 Applied Project_Guidance for Reviewing and Approving a Waste Stream Profile in the Waste Compliance and Tracking System_Final_05-05-15

Energy Technology Data Exchange (ETDEWEB)

Elicio, Andy U. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2015-05-05

My ERM 593 applied project will provide guidance for the Los Alamos National Laboratory Waste Stream Profile reviewer (i.e. RCRA reviewer) in regards to Reviewing and Approving a Waste Stream Profile in the Waste Compliance and Tracking System. The Waste Compliance and Tracking system is called WCATS. WCATS is a web-based application that “supports the generation, characterization, processing and shipment of LANL radioactive, hazardous, and industrial waste.” The LANL generator must characterize their waste via electronically by filling out a waste stream profile (WSP) in WCATS. Once this process is completed, the designated waste management coordinator (WMC) will perform a review of the waste stream profile to ensure the generator has completed their waste stream characterization in accordance with applicable state, federal and LANL directives particularly P930-1, “LANL Waste Acceptance Criteria,” and the “Waste Compliance and Tracking System User's Manual, MAN-5004, R2,” as applicable. My guidance/applied project will describe the purpose, scope, acronyms, definitions, responsibilities, assumptions and guidance for the WSP reviewer as it pertains to each panel and subpanel of a waste stream profile.

BWR AXIAL PROFILE

International Nuclear Information System (INIS)

Huffer, J.

2004-01-01

The purpose of this calculation is to develop axial profiles for estimating the axial variation in burnup of a boiling water reactor (BWR) assembly spent nuclear fuel (SNF) given the average burnup of an assembly. A discharged fuel assembly typically exhibits higher burnup in the center and lower burnup at the ends of the assembly. Criticality safety analyses taking credit for SNF burnup must account for axially varying burnup relative to calculations based on uniformly distributed assembly average burnup due to the under-burned tips. Thus, accounting for axially varying burnup in criticality analyses is also referred to as accounting for the ''end effect'' reactivity. The magnitude of the reactivity change due to ''end effect'' is dependent on the initial assembly enrichment, the assembly average burnup, and the particular axial profile characterizing the burnup distribution. The set of bounding axial profiles should incorporate multiple BWR core designs and provide statistical confidence (95 percent confidence that 95 percent of the population is bound by the profile) that end nodes are conservatively represented. The profiles should also conserve the overall burnup of the fuel assembly. More background on BWR axial profiles is provided in Attachment I

Application of Electromagnetic Induction to Monitor Changes in Soil Electrical Conductivity Profiles in Arid Agriculture

KAUST Repository

Jadoon, K.Z.; McCabe, Matthew; Moghadas, D.

2015-01-01

In this research, multi-configuration electromagnetic induction (EMI) measurements were conducted in a corn field to estimate variation in soil electrical conductivity profiles in the roots zone. Electromagnetic forward model based on the full

A handheld optical device for skin profile measurement

Science.gov (United States)

Sun, Jiuai; Liu, Xiaojin

2018-04-01

This paper describes a portable optical scanning device designed for skin surface measurement on both colour and 3D geometry through a relative easy and cost effective multiple light source photometric stereo method. The validation of colour recovered had been verified through its application on skin lesion segmentation in our early work. This paper focuses on the reconstructed topographic data which are subject to further evaluation and advancement. The evaluation work takes the skin in vitro as an application scenario and compares the experimental result to that obtained by using a commercial product. The experiments show that this handheld device can measure the skin profile significantly closer to that of the ground truth and have the additional function of skin colour recovery.

Statistically sound evaluation of trace element depth profiles by ion beam analysis

International Nuclear Information System (INIS)

Schmid, K.; Toussaint, U. von

2012-01-01

This paper presents the underlying physics and statistical models that are used in the newly developed program NRADC for fully automated deconvolution of trace level impurity depth profiles from ion beam data. The program applies Bayesian statistics to find the most probable depth profile given ion beam data measured at different energies and angles for a single sample. Limiting the analysis to % level amounts of material allows one to linearize the forward calculation of ion beam data which greatly improves the computation speed. This allows for the first time to apply the maximum likelihood approach to both the fitting of the experimental data and the determination of confidence intervals of the depth profiles for real world applications. The different steps during the automated deconvolution will be exemplified by applying the program to artificial and real experimental data.

Hydrophobically associating polymers for oil field applications

Energy Technology Data Exchange (ETDEWEB)

Taylor, K.C. [Taylor Industrial Research Inc., Victoria, BC (Canada); Nasr-El-Din, H.A. [Saudi Aramco, Dharhan (Saudi Arabia). R and D Center

2007-07-01

This paper discussed developments in water soluble hydrophobically associating polymers and their use in oilfield applications. The polymers are now being investigated for the potential application in enhanced oil recovery (EOR) as well as in completion fluids and profile modifications. The polymers are also purported to selectively reduce water permeability in sandstones. This study showed that the adsorption behaviour of the associating polymers is of greater significance than the rheology, particularly in non-damaging completion fluids and in profile modification. Issues related to acid diversion and conformance control applications were discussed, and drag reducing agents were reviewed. The study also discussed drilling and completion fluids; adsorption behaviour; rheology; and synthesis and characterization. It was concluded that gels are now being developed for conformance control and continued use for modification of water relative permeability. 35 refs., 5 figs.

An optical fiber expendable seawater temperature/depth profile sensor

Science.gov (United States)

Zhao, Qiang; Chen, Shizhe; Zhang, Keke; Yan, Xingkui; Yang, Xianglong; Bai, Xuejiao; Liu, Shixuan

2017-10-01

Marine expendable temperature/depth profiler (XBT) is a disposable measuring instrument which can obtain temperature/depth profile data quickly in large area waters and mainly used for marine surveys, scientific research, military application. The temperature measuring device is a thermistor in the conventional XBT probe (CXBT)and the depth data is only a calculated value by speed and time depth calculation formula which is not an accurate measurement result. Firstly, an optical fiber expendable temperature/depth sensor based on the FBG-LPG cascaded structure is proposed to solve the problems of the CXBT, namely the use of LPG and FBG were used to detect the water temperature and depth, respectively. Secondly, the fiber end reflective mirror is used to simplify optical cascade structure and optimize the system performance. Finally, the optical path is designed and optimized using the reflective optical fiber end mirror. The experimental results show that the sensitivity of temperature and depth sensing based on FBG-LPG cascade structure is about 0.0030C and 0.1%F.S. respectively, which can meet the requirements of the sea water temperature/depth observation. The reflectivity of reflection mirror is in the range from 48.8% to 72.5%, the resonant peak of FBG and LPG are reasonable and the whole spectrum are suitable for demodulation. Through research on the optical fiber XBT (FXBT), the direct measurement of deep-sea temperature/depth profile data can be obtained simultaneously, quickly and accurately. The FXBT is a new all-optical seawater temperature/depth sensor, which has important academic value and broad application prospect and is expected to replace the CXBT in the future.

Creating preservation metadata from XML-metadata profiles

Science.gov (United States)

Ulbricht, Damian; Bertelmann, Roland; Gebauer, Petra; Hasler, Tim; Klump, Jens; Kirchner, Ingo; Peters-Kottig, Wolfgang; Mettig, Nora; Rusch, Beate

2014-05-01

Metadata Encoding and Transmission Standard (METS). To find datasets in future portals and to make use of this data in own scientific work, proper selection of discovery metadata and application metadata is very important. Some XML-metadata profiles are not suitable for preservation, because version changes are very fast and make it nearly impossible to automate the migration. For other XML-metadata profiles schema definitions are changed after publication of the profile or the schema definitions become inaccessible, which might cause problems during validation of the metadata inside the preservation system [2]. Some metadata profiles are not used widely enough and might not even exist in the future. Eventually, discovery and application metadata have to be embedded into the mdWrap-subtree of the METS-XML. [1] http://www.archivematica.org [2] http://dx.doi.org/10.2218/ijdc.v7i1.215

Whole genome expression profiling using DNA microarray for determining biocompatibility of polymeric surfaces

DEFF Research Database (Denmark)

Stangegaard, Michael; Wang, Zhenyu; Kutter, Jörg Peter

2006-01-01

There is an ever increasing need to find surfaces that are biocompatible for applications like medical implants and microfluidics-based cell culture systems. The biocompatibility of five different surfaces with different hydrophobicity was determined using gene expression profiling as well as more...

Diagnose Test-Taker's Profile in Terms of Core Profile Patterns: Principal Component (PC) vs. Profile Analysis via MDS (PAMS) Approaches.

Science.gov (United States)

Kim, Se-Kang; Davison, Mark L.

A study was conducted to examine how principal components analysis (PCA) and Profile Analysis via Multidimensional Scaling (PAMS) can be used to diagnose individuals observed score profiles in terms of core profile patterns identified by each method. The standardization sample from the Wechsler Intelligence Scale for Children, Third Edition…

HMMBinder: DNA-Binding Protein Prediction Using HMM Profile Based Features.

Science.gov (United States)

Zaman, Rianon; Chowdhury, Shahana Yasmin; Rashid, Mahmood A; Sharma, Alok; Dehzangi, Abdollah; Shatabda, Swakkhar

2017-01-01

DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinder uses monogram and bigram features extracted from the HMM profiles of the protein sequences. To the best of our knowledge, this is the first application of HMM profile based features for the DNA-binding protein prediction problem. We applied Support Vector Machines (SVM) as a classification technique in HMMBinder. Our method was tested on standard benchmark datasets. We experimentally show that our method outperforms the state-of-the-art methods found in the literature.

HMMBinder: DNA-Binding Protein Prediction Using HMM Profile Based Features

Directory of Open Access Journals (Sweden)

Rianon Zaman

2017-01-01

Full Text Available DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinder uses monogram and bigram features extracted from the HMM profiles of the protein sequences. To the best of our knowledge, this is the first application of HMM profile based features for the DNA-binding protein prediction problem. We applied Support Vector Machines (SVM as a classification technique in HMMBinder. Our method was tested on standard benchmark datasets. We experimentally show that our method outperforms the state-of-the-art methods found in the literature.

Youth Sports Clubs' Potential as Health-Promoting Setting: Profiles, Motives and Barriers

Science.gov (United States)

Meganck, Jeroen; Scheerder, Jeroen; Thibaut, Erik; Seghers, Jan

2015-01-01

Setting and Objective: For decades, the World Health Organisation has promoted settings-based health promotion, but its application to leisure settings is minimal. Focusing on organised sports as an important leisure activity, the present study had three goals: exploring the health promotion profile of youth sports clubs, identifying objective…

Spectral backward radiation profile

International Nuclear Information System (INIS)

Kwon, Sung Duck; Lee, Keun Hyun; Kim, Bo Ra; Yoon, Suk Soo

2004-01-01

Ultrasonic backward radiation profile is frequency-dependent when incident region has deptional gradient of acoustical properties or multi-layers. Until now, we have measured the profiles of principal frequencies of used transducers so that it was not easy to understand the change of the frequency component and spectrum of backward radiation from the profile. We tried to measure the spectral backward radiation profiles using DFP(digital filer package) Lecroy DSO. The very big changes in the shape and pattern of spectral backward radiation profiles leads to the conclusion that this new try could be very effective tool to evaluate frequency dependent surface area.

Prognostic Impact of Array-based Genomic Profiles in Esophageal Squamous Cell Cancer

International Nuclear Information System (INIS)

Carneiro, Ana; Isinger, Anna; Karlsson, Anna; Johansson, Jan; Jönsson, Göran; Bendahl, Pär-Ola; Falkenback, Dan; Halvarsson, Britta; Nilbert, Mef

2008-01-01

Esophageal squamous cell carcinoma (ESCC) is a genetically complex tumor type and a major cause of cancer related mortality. Although distinct genetic alterations have been linked to ESCC development and prognosis, the genetic alterations have not gained clinical applicability. We applied array-based comparative genomic hybridization (aCGH) to obtain a whole genome copy number profile relevant for identifying deranged pathways and clinically applicable markers. A 32 k aCGH platform was used for high resolution mapping of copy number changes in 30 stage I-IV ESCC. Potential interdependent alterations and deranged pathways were identified and copy number changes were correlated to stage, differentiation and survival. Copy number alterations affected median 19% of the genome and included recurrent gains of chromosome regions 5p, 7p, 7q, 8q, 10q, 11q, 12p, 14q, 16p, 17p, 19p, 19q, and 20q and losses of 3p, 5q, 8p, 9p and 11q. High-level amplifications were observed in 30 regions and recurrently involved 7p11 (EGFR), 11q13 (MYEOV, CCND1, FGF4, FGF3, PPFIA, FAD, TMEM16A, CTTS and SHANK2) and 11q22 (PDFG). Gain of 7p22.3 predicted nodal metastases and gains of 1p36.32 and 19p13.3 independently predicted poor survival in multivariate analysis. aCGH profiling verified genetic complexity in ESCC and herein identified imbalances of multiple central tumorigenic pathways. Distinct gains correlate with clinicopathological variables and independently predict survival, suggesting clinical applicability of genomic profiling in ESCC

Assessing one-dimensional diffusion in nanoporous materials from transient concentration profiles

International Nuclear Information System (INIS)

Heinke, Lars; Kaerger, Joerg

2008-01-01

The use of interference microscopy has enabled the direct observation of transient concentration profiles generated by intracrystalline transport diffusion in nanoporous materials. The thus accessible intracrystalline concentration profiles contain a wealth of information which cannot be deduced by any macroscopic method. In this paper, we illustrate five different ways for determining the concentration-dependent diffusivity in one-dimensional systems and two for the surface permeability. These methods are discussed by application to concentration profiles evolving during the uptake of methanol by the zeolite ferrierite and of methanol by the metal organic framework (MOF) manganese(II) formate. We show that the diffusivity can be calculated most precisely by means of Fick's 1st law. As the circumstances permit, Boltzmann's integration method also yields very precise results. Furthermore, we present a simple procedure that enables the estimation of the influence of the surface barrier on the overall uptake process by plotting the boundary concentration versus the overall uptake

Williams syndrome-specific neuroanatomical profile and its associations with behavioral features.

Science.gov (United States)

Fan, Chun Chieh; Brown, Timothy T; Bartsch, Hauke; Kuperman, Joshua M; Hagler, Donald J; Schork, Andrew; Searcy, Yvonne; Bellugi, Ursula; Halgren, Eric; Dale, Anders M

2017-01-01

Williams Syndrome (WS) is a rare genetic disorder with unique behavioral features. Yet the rareness of WS has limited the number and type of studies that can be conducted in which inferences are made about how neuroanatomical abnormalities mediate behaviors. In this study, we extracted a WS-specific neuroanatomical profile from structural magnetic resonance imaging (MRI) measurements and tested its association with behavioral features of WS. Using a WS adult cohort (22 WS, 16 healthy controls), we modeled a sparse representation of a WS-specific neuroanatomical profile. The predictive performances are robust within the training cohort (10-fold cross-validation, AUC = 1.0) and accurately identify all WS individuals in an independent child WS cohort (seven WS, 59 children with diverse developmental status, AUC = 1.0). The WS-specific neuroanatomical profile includes measurements in the orbitofrontal cortex, superior parietal cortex, Sylvian fissures, and basal ganglia, and variability within these areas related to the underlying size of hemizygous deletion in patients with partial deletions. The profile intensity mediated the overall cognitive impairment as well as personality features related to hypersociability. Our results imply that the unique behaviors in WS were mediated through the constellation of abnormalities in cortical-subcortical circuitry consistent in child WS and adult WS. The robustness of the derived WS-specific neuroanatomical profile also demonstrates the potential utility of our approach in both clinical and research applications.

Accelerated testing of solid oxide fuel cell stacks for micro combined heat and power application

DEFF Research Database (Denmark)

Hagen, Anke; Høgh, Jens Valdemar Thorvald; Barfod, Rasmus

2015-01-01

State-of-the-art (SoA) solid oxide fuel cell (SOFC) stacks are tested using profiles relevant for use in micro combined heat and power (CHP) units. Such applications are characterised by dynamic load profiles. In order to shorten the needed testing time and to investigate potential acceleration...... of degradation, the profiles are executed faster than required for real applications. Operation with fast load cycling, both using hydrogen and methane/steam as fuels, does not accelerate degradation compared to constant operation, which demonstrates the maturity of SoA stacks and enables transferring knowledge...... effect for long life-times than regular short time changes of operation. In order to address lifetime testing it is suggested to build a testing program consisting of defined modules that represent different application profiles, such as one module at constant conditions, followed by modules at one set...

Preliminary study on application of urine amino acids profiling for monitoring of renal tubular injury using GLC-MS.

Science.gov (United States)

Kazubek-Zemke, Maja; Rybka, Jacek; Marchewka, Zofia; Rybka, Wojciech; Pawlik, Krzysztof; Długosz, Anna

2014-11-14

The early diagnosis of the nephrotoxic effect of xenobiotics and drugs is still an unsolved problem. Recent studies suggest a correlation between the nephrotoxic activity of xenobiotics and increased concentration of amino acids in urine. The presented study was focused on the application of GLC-MS method for amino acids profiling in human urine as a noninvasive method for monitoring of kidney condition and tubular injury level. The analytic method is based on the conversion of the amino acids present in the sample to tert-butyldimethylsilyl (TBDMS) derivatives and their analysis by gas-liquid chromatography-mass spectrometry (GLC-MS). The procedure of urine sample preparation for chromatographic analysis was optimized. The presence of 12 amino acids in most of the tested healthy human urine samples was detected. The significant differences in the levels of particular amino acids between patients with tubular injury and healthy controls were found, especially for lysine, valine, serine, alanine and leucine (on average 30.0, 7.5, 3.6, 2.9 and 0.5 fold respectively). We found that this approach based on GLC-MS detection can be used in nephrotoxicity studies for urine amino acids monitoring in exposure to xenobiotics and drugs.

APPLICATION OF ALLOMETRY FOR DETERMINATION OF STRENGTH PROFILE IN YOUNG FEMALE ATHLETES FROM DIFFERENT SPORTS

Directory of Open Access Journals (Sweden)

J. Gajewski

2011-11-01

Full Text Available The goal of the study was to determine a strength profile in young female athletes practising different sports and to use allometry to evaluate muscular strength with respect to body mass. The study included 42 women who practised taekwondo (n = 10, weightlifting (n = 10, canoeing (n = 14 and speed skating (n = 8. Measurements of maximal muscle torques under static conditions in 10 groups of flexors and extensors of the elbow, shoulder, hip, knee and trunk were carried out. The MANCOVA procedure was employed to compare means between the groups. A logarithm of body mass was adopted as a covariate. Relationships between body mass and muscle torques in each muscle group were determined using a procedure of linear regression. The analysis of residuals was employed for the evaluation of maximal muscle torques. Mean values of logarithms of maximal muscle torques were significantly different for the representatives of individual sports and they depended on the logarithm of body mass. It was proposed to use a mean of residuals normalized for individual muscle groups as a synthetic strength index (mean of the strength profile. The women practising canoeing were characterized by the highest strength index. Its lowest values were obtained by weightlifting and taekwondo athletes. Differences in strength profiles in the tested athletes were attributed to the specific nature of their sports. It is suggested to use an allometric relationship scaled by body mass for strength assessment.

Wear-Induced Changes in FSW Tool Pin Profile: Effect of Process Parameters

Science.gov (United States)

Sahlot, Pankaj; Jha, Kaushal; Dey, G. K.; Arora, Amit

2018-06-01

Friction stir welding (FSW) of high melting point metallic (HMPM) materials has limited application due to tool wear and relatively short tool life. Tool wear changes the profile of the tool pin and adversely affects weld properties. A quantitative understanding of tool wear and tool pin profile is crucial to develop the process for joining of HMPM materials. Here we present a quantitative wear study of H13 steel tool pin profile for FSW of CuCrZr alloy. The tool pin profile is analyzed at multiple traverse distances for welding with various tool rotational and traverse speeds. The results indicate that measured wear depth is small near the pin root and significantly increases towards the tip. Near the pin tip, wear depth increases with increase in tool rotational speed. However, change in wear depth near the pin root is minimal. Wear depth also increases with decrease in tool traverse speeds. Tool pin wear from the bottom results in pin length reduction, which is greater for higher tool rotational speeds, and longer traverse distances. The pin profile changes due to wear and result in root defect for long traverse distance. This quantitative understanding of tool wear would be helpful to estimate tool wear, optimize process parameters, and tool pin shape during FSW of HMPM materials.

Testing Two Nutrient Profiling Models of Labelled Foods and Beverages Marketed in Turkey.

Science.gov (United States)

Dikmen, Derya; Kızıl, Mevlüde; Uyar, Muhemmet Fatih; Pekcan, Gülden

2015-06-01

The objective of this study was to evaluate the nutrient profile of labelled foods and also understand the application of two international nutrient profiling models of labelled foods and beverages. WXYfm and NRF 9.3 nutrient profiling models were used to evaluate 3,171 labelled foods and beverages of 38 food categories and 500 different brands. According to the WXYfm model, pasta, grains and legumes and frozen foods had the best scores whereas oils had the worst scores. According to the NRF 9.3 model per 100 kcal, the best scores were obtained for frozen foods, grains and legumes and milk products whereas the confectionery foods had the worst scores. According to NRF 9.3 per serving size, grains and legumes had the best scores and flavoured milks had the worst scores. A comparison of WXYfm and NRF 9.3 nutrient profiling models ranked scores showed a high positive correlation (p=0.01). The two nutrient models evaluated yielded similar results. Further studies are needed to test other category specific nutrient profiling models in order to understand how different models behave. Copyright© by the National Institute of Public Health, Prague 2015.

The characterization of beam profile by modification of electrode shape

International Nuclear Information System (INIS)

Lee, Chan Young; Lee, Jae Sang

2010-01-01

Ion sources have been used for variety of industrial application over the past few decades and our research group has been studied about high current and large dimension ion source to meet the requirement from beam user. For a mass production in industry, a wide beam divergence and a beam profile of a broadly Gaussian shape is very needed. Generally, the production process like roll-to-roll or in-line system is need one-meter in diameter, ±5% in uniformity. Therefore it is difficult to apply with present system like 0.3-meter in diameter, ±20% in uniformity and needed new type ion source. In this study, it is approached with modification of electrode grid shape without fabrication of new type ion source. We modified from parallel type to hemispherical type electrode grid to secure large dimension ion beam and were discussed with respect to beam profile calculated with IGUN code simulation. Also, we identified beam profile before and after modification of electrode grid system(cathode, Acelldecel grid) with measurement of faraday cup

Molecular profiling--a tool for addressing emerging gaps in the comparative risk assessment of GMOs.

Science.gov (United States)

Heinemann, Jack A; Kurenbach, Brigitta; Quist, David

2011-10-01

Assessing the risks of genetically modified organisms (GMOs) is required by both international agreement and domestic legislation. Many view the use of the "omics" tools for profiling classes of molecules as useful in risk assessment, but no consensus has formed on the need or value of these techniques for assessing the risks of all GMOs. In this and many other cases, experts support case-by-case use of molecular profiling techniques for risk assessment. We review the latest research on the applicability and usefulness of molecular profiling techniques for GMO risk assessment. As more and more kinds of GMOs and traits are developed, broader use of molecular profiling in a risk assessment may be required to supplement the comparative approach to risk assessment. The literature-based discussions on the use of profiling appear to have settled on two findings: 1. profiling techniques are reliable and relevant, at least no less so than other techniques used in risk assessment; and 2. although not required routinely, regulators should be aware of when they are needed. The dismissal of routine molecular profiling may be confusing to regulators who then lack guidance on when molecular profiling might be worthwhile. Molecular profiling is an important way to increase confidence in risk assessments if the profiles are properly designed to address relevant risks and are applied at the correct stage of the assessment. Copyright © 2011 Elsevier Ltd. All rights reserved.

A brief history of the development of wind-profiling or MST radars

Directory of Open Access Journals (Sweden)

T. E. Van Zandt

Full Text Available The history of the development of the wind-profiling or MST radar technique is reviewed from its inception in the late 1960s to the present. Extensions of the technique by the development of boundary-layer radars and the radio-acoustic sounding system (RASS technique to measure temperature are documented. Applications are described briefly, particularly practical applications to weather forecasting, with data from networks of radars, and scientific applications to the study of rapidly varying atmospheric phenomena such as gravity waves and turbulence.

Key words: Meteorology and atmospheric dynamics (instruments and techniques · Radio science (remote sensing; instruments and techniques

Design and application of natural product derived probes for activity based protein profiling

OpenAIRE

Battenberg, Oliver Alexander

2015-01-01

The identification of new antibacterial protein targets by activity based protein profiling (ABPP) is an important approach to face the increasing emergence of resistant bacteria. The scope of this work focuses on three new strategies for the labeling of antibacterial protein-targets with natural product derived ABPP-probes: A.) Evaluation of the intrinsic photo-reactivity of α-pyrones and pyrimidones for use as photo-crosslinkers. B.) Synthesis of a benzophenone-tag that combines photo-cross...

HOPWA Performance Profiles

Data.gov (United States)

Department of Housing and Urban Development — HOPWA Performance Profiles are generated quarterly for all agencies receiving HOPWA formula or competitive grants. Performance Profiles are available at the national...

Application of solid phase micro extraction (SPME) in profiling hydrocarbons in oil spill cases

International Nuclear Information System (INIS)

Zuraidah Abdullah Munir; Norashikin Saim; Nurul Huda Mamat Ghani

2008-01-01

In environmental forensic, it is extremely important to have a fast and reliable method in identifying sources of spilled oil and petroleum products. In this study, solid phase micro extraction (SPME) method coupled to gas chromatography-mass spectrometry was developed for the analysis of hydrocarbons in diesel and petroleum contaminated soil samples. Optimization of SPME parameters such as extraction time, extraction temperature and desorption time, was performed using 100-μm poly dimethylsiloxane (PDMS) fiber. These parameters were studied at three levels by means of a central composite experimental design and the optimum experimental conditions were determined using response surface method. The developed SPME method was applied to determine the profiles of hydrocarbons in several oil contaminated soil sample. The SPME method was also used to study the effects of weathering on the profiles of hydrocarbons in unleaded gasoline, diesel and kerosene contaminated soil samples. After several days, significant losses of the lighter hydrocarbons were observed compared to the heavier ones. From these data, SPME method can be used to differentiate possible candidate sources in oil spill cases. (author)

Jack'd, a Mobile Social Networking Application: A Site of Exclusion Within a Site of Inclusion.

Science.gov (United States)

Bartone, Michael D

2018-01-01

User-generated smartphone applications have created a new level of virtual connectivity for gay males, one in which users can create profiles and meet other users as nearby or as far away as possible. For those within close proximity, the other users can be considered their "virtual neighbors." Although the applications are theoretically designed to be places of inclusion and not exclusion, where any gay male with economic means can download an application, many profiles have been created that exclude other users. Through an examination of profiles on one such application, Jack'd, exclusion is found in the way users celebrate and reinforce ideas of traditional masculinity and denigrate and reinforce stereotypic ideas of femininity embodied by some gay men. Jack'd, and other user-generated smartphone applications, can be read as virtual neighborhoods where one is excluded based on their gender performance.

Electron Density Profile Data Contains Virtual Height/Frequency Pairs from a Profile or Profiles (Composite Months) of Ionograms

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Electron Density Profile, N(h), data set contains both individual profiles and composite months. The data consist of virtual height/frequency pairs from a...

Heavy metal movement in metal-contaminated soil profiles

Energy Technology Data Exchange (ETDEWEB)

Li, Zhenbin; Shuman, L.M. [Univ. of Georgia, Griffin, GA (United States)

1996-10-01

Heavy metal movement in soil profiles is a major environmental concern because even slow transport through the soil may eventually lead to deterioration of groundwater quality. In this study, three metal-contaminated soil (Fuquay, Dothan, and Clarendon) were selected from cropland were a high-metal flue dust had been applied annually for 6 years to raise soil pH, with application ending 4 years before sampling. One uncontaminated soil (Tifton) from the same physiographic area was also sampled as a control. Soil samples were collected in 15-cm increments from the surface to 105 cm in depth. Total contents of Zn, Cd, and Pb in the soils samples were determined. To better understand metal movement in relation to metal fractions in the soil profile, soil samples were also extracted sequentially for exchangeable (EXC), organic matter (OM), Mn oxide (MNO), amorphous Fe oxide (AFEO), crystalline Fe oxide (CFEO), and residual (RES) fractions. 35 refs., 6 figs., 2 tabs.

Profile of Cognitive Ability and Multiple Intelligence of Vocational Students in Application of Electric Energy Conservation

Science.gov (United States)

Kurniawan, A.; Rustaman, N. Y.; Kaniawati, I.; Hasanah, L.

2017-09-01

The purpose of this study is to obtain a profile picture of cognitive ability and multiple intelligence of students on physics learning activities in relation to the discourse of conservation of electrical energy. Research activities are conducted in the even semester of the 2015/2016 school year. The subjects of the study were the students of class XI (36 students) in one of the state vocational schools in Bandung consisting of one class chosen at random (cluster random sampling). Research data in the form of cognitive ability test results and multiple intelligences are analyzed descriptively and qualitatively. Research data is then analyzed and compared with predetermined success indicators. The results showed that the cognitive abilities profile of students in vocational schools in Bandung is still low. This can be seen from the average score of cognitive ability of students in remember (C1) of 57.75, understanding (C2) of 53.50, applying (C3) of 43.75, and analyzing (C4) of 37.75. The multiple intelligence profiles indicate frequency of linguistic intelligence number 9 students, musical intelligence 3 students, logical mathematical intelligence 13 students, spatial intelligence 7 students, kinesthetic intelligence 5 students, intrapersonal intelligence 7 students, interpersonal intelligence 6 students, and naturalistic intelligence 5 students.

First steps towards cube textured nickel profile wires for YBCO-coated conductors

International Nuclear Information System (INIS)

Eickemeyer, J.; Gueth, A.; Freudenberger, J.; Holzapfel, B.; Schultz, L.

2011-01-01

The cube texture as a typical sheet texture can also be formed by cold drawing and recrystallization in profile wires. Cube textured Ni profile wires containing up to 96.2% cube oriented grains in the central region were obtained. Forthcoming investigations are promising to get a textured substrate wire for YBCO-coated conductors. Cube textured nickel alloy tapes prepared by cold rolling and annealing (RABiTS method) represent a standard metallic substrate for superconductor coatings of the YBa 2 Cu 3 O 7-δ (YBCO) type. These tapes have a width to thickness ratio of about 30-100. However, a value of close to one is optimal concerning low energetic losses under alternating current applications. First experiments on micro-alloyed nickel prove that the cube texture as a typical sheet texture can also be formed in profile wires with a rectangular cross-section after cold drawing and recrystallization treatment.

Comparison of commercial exosome isolation kits for circulating exosomal microRNA profiling.

Science.gov (United States)

Ding, Meng; Wang, Cheng; Lu, Xiaolan; Zhang, Cuiping; Zhou, Zhen; Chen, Xi; Zhang, Chen-Yu; Zen, Ke; Zhang, Chunni

2018-06-01

Circulating exosomal microRNAs (miRNAs) are valuable biomarker candidates; however, information on the characterization and mutual agreement of commercial kits for circulating exosomal miRNA profiling is scarce. Here, we analyzed the advantages and weaknesses of four commonly used commercial kits for exosomal miRNA profiling and their application to the sample of serum and/or plasma, respectively. NanoSight and Western blotting were conducted to evaluate the efficiency and purity of the isolated exosomes. In our conditions, the size distribution of the isolated particles was appropriate (40-150 nm), and ExoQuick™ Exosome Precipitation Solution (EXQ) generated a relatively high yield of exosomes. Nevertheless, albumin impurity was ubiquitous for all the four kits, and Total Exosome Isolation for serum or plasma (TEI) yielded a relatively pure isolation. We further performed Illumina sequencing combined with RT-qPCR to determine the ability of these kits for miRNA profiling. There was significant correlation of the exosomal miRNA profile and specific miRNAs between kits, but with differences depending on methods. exoRNeasy Serum/Plasma Midi Kit (EXR) and EXQ performed better in the specific exosomal miRNAs recovery. Intraassay CVs for specific miRNA measurement were 0.88-3.82, 1.19-3.77, 0-2.70, and 1.23-9.11% for EXR, TEI, EXQ, and RIBO™ Exosome Isolation Reagent (REI), respectively. In each kit, serum yielded a higher abundance of exosomes and exosomal miRNAs than plasma, yet with more albumin impurity. In conclusion, our data provide some valuable guidance for the methodology of disease biomarker identification of circulation exosomal miRNAs. Graphical abstract Circulating exosomal microRNAs (miRNAs) are valuable biomarker candidates; however, information on the characterization and mutual agreement of commercial kits for circulating exosomal miRNA profiling is scarce. In this study, we compared four commonly used commercially available kits for exosomal mi

Study on Rail Profile Optimization Based on the Nonlinear Relationship between Profile and Wear Rate

Directory of Open Access Journals (Sweden)

Jianxi Wang

2017-01-01

Full Text Available This paper proposes a rail profile optimization method that takes account of wear rate within design cycle so as to minimize rail wear at the curve in heavy haul railway and extend the service life of rail. Taking rail wear rate as the object function, the vertical coordinate of rail profile at range optimization as independent variable, and the geometric characteristics and grinding depth of rail profile as constraint conditions, the support vector machine regression theory was used to fit the nonlinear relationship between rail profile and its wear rate. Then, the profile optimization model was built. Based on the optimization principle of genetic algorithm, the profile optimization model was solved to achieve the optimal rail profile. A multibody dynamics model was used to check the dynamic performance of carriage running on optimal rail profile. The result showed that the average relative error of support vector machine regression model remained less than 10% after a number of training processes. The dynamic performance of carriage running on optimized rail profile met the requirements on safety index and stability. The wear rate of optimized profile was lower than that of standard profile by 5.8%; the allowable carrying gross weight increased by 12.7%.

Facebook Applications' Installation and Removal: A Temporal Analysis

OpenAIRE

Kagan, Dima; Fire, Michael; Elyashar, Aviad; Elovici, Yuval

2013-01-01

Facebook applications are one of the reasons for Facebook attractiveness. Unfortunately, numerous users are not aware of the fact that many malicious Facebook applications exist. To educate users, to raise users' awareness and to improve Facebook users' security and privacy, we developed a Firefox add-on that alerts users to the number of installed applications on their Facebook profiles. In this study, we present the temporal analysis of the Facebook applications' installation and removal da...

Impact of mismatched and misaligned laser light sheet profiles on PIV performance

Science.gov (United States)

Grayson, K.; de Silva, C. M.; Hutchins, N.; Marusic, I.

2018-01-01

The effect of mismatched or misaligned laser light sheet profiles on the quality of particle image velocimetry (PIV) results is considered in this study. Light sheet profiles with differing widths, shapes, or alignment can reduce the correlation between PIV images and increase experimental errors. Systematic PIV simulations isolate these behaviours to assess the sensitivity and implications of light sheet mismatch on measurements. The simulations in this work use flow fields from a turbulent boundary layer; however, the behaviours and impacts of laser profile mismatch are highly relevant to any fluid flow or PIV application. Experimental measurements from a turbulent boundary layer facility are incorporated, as well as additional simulations matched to experimental image characteristics, to validate the synthetic image analysis. Experimental laser profiles are captured using a modular laser profiling camera, designed to quantify the distribution of laser light sheet intensities and inform any corrective adjustments to an experimental configuration. Results suggest that an offset of just 1.35 standard deviations in the Gaussian light sheet intensity distributions can cause a 40% reduction in the average correlation coefficient and a 45% increase in spurious vectors. Errors in measured flow statistics are also amplified when two successive laser profiles are no longer well matched in alignment or intensity distribution. Consequently, an awareness of how laser light sheet overlap influences PIV results can guide faster setup of an experiment, as well as achieve superior experimental measurements.

Depth profiling using C60+ SIMS-Deposition and topography development during bombardment of silicon

International Nuclear Information System (INIS)

Gillen, Greg; Batteas, James; Michaels, Chris A.; Chi, Peter; Small, John; Windsor, Eric; Fahey, Albert; Verkouteren, Jennifer; Kim, K.J.

2006-01-01

A C 60 + primary ion source has been coupled to an ion microscope secondary ion mass spectrometry (SIMS) instrument to examine sputtering of silicon with an emphasis on possible application of C 60 + depth profiling for high depth resolution SIMS analysis of silicon semiconductor materials. Unexpectedly, C 60 + SIMS depth profiling of silicon was found to be complicated by the deposition of an amorphous carbon layer which buries the silicon substrate. Sputtering of the silicon was observed only at the highest accessible beam energies (14.5 keV impact) or by using oxygen backfilling. C 60 + SIMS depth profiling of As delta-doped test samples at 14.5 keV demonstrated a substantial (factor of 5) degradation in depth resolution compared to Cs + SIMS depth profiling. This degradation is thought to result from the formation of an unusual platelet-like grain structure on the SIMS crater bottoms. Other unusual topographical features were also observed on silicon substrates after high primary ion dose C 60 + bombardment

Research and application of online measurement system of tire tread profile in automobile tire production

Science.gov (United States)

Wang, Pengyao; Chen, Xiangguang; Yang, Kai; Liu, Xuejiao

2017-01-01

To improve the measuring efficiency of width and thickness of tire tread in the process of automobile tire production, the actual condition for the tire production process is analyzed, and a fast online measurement system based on moving tire tread of tire specifications is established in this paper. The coordinate data of tire tread profile is acquired by 3D laser sensor, and we use C# language for programming which is an object-oriented programming language to complete the development of client program. The system with laser sensor can provide real-time display of tire tread profile and the data to require in the process of tire production. Experimental results demonstrate that the measuring precision of the system is <= 1mm, it can meet the measurement requirements of the production process, and the system has the characteristics of convenient installation and testing, system stable operation.

SIMS depth profile analysis of environmental microparticles

International Nuclear Information System (INIS)

Konarski, P.

2000-01-01

Environmental and technological research demands chemical characterization of aerosol particles so minute in size, that conventional methods for bulk analyses are simply not applicable. In this work novel application of secondary ion mass spectrometry (SIMS) for characterization of microparticles suspended in atmosphere of the working environment of glass plant Thomson Polkolor, Piaseczno and steelworks Huta Sendzimira, Cracow is presented. The new technique based on sample rotation in depth profile analysis of sub-micrometer particulate material was performed on SAJW-02 analyser equipped with Balzers 16 mm quadrupole spectrometer and sample rotation manipulator using 5 keV Ar + and O 2 + ion beams. The results were compared with the standard method used on ims-3f Cameca analyser 12 keV O 2 + ion beam. Grain size distributions of aerosol microparticles were estimated using eight-stage cascade impactor with particle size range of 0.2 μm to 15 μm. Elemental concentration and crystalline structure of the collected dust particles were performed using spark source mass spectrometry and X-ray diffraction methods. SIMS depth profile analysis shows that sub-micrometer particles do not have uniform morphology, The core-shell structure has been observed for particles collected in both factories. Presented models show that the steelworks particles consists mainly of iron and manganese cores. At the shells of these microparticles :lead, chlorine and fluorine are found. The cores of glass plant submicrometer particles consists mainly of lead-zirconium glass covered by a shell containing carbon and copper. Sample rotation technique applied SIMS appears to be an effective tool for environmental microparticle morphology studies. (author)

Inverse modeling of FIB milling by dose profile optimization

International Nuclear Information System (INIS)

Lindsey, S.; Waid, S.; Hobler, G.; Wanzenböck, H.D.; Bertagnolli, E.

2014-01-01

FIB technologies possess a unique ability to form topographies that are difficult or impossible to generate with binary etching through typical photo-lithography. The ability to arbitrarily vary the spatial dose distribution and therefore the amount of milling opens possibilities for the production of a wide range of functional structures with applications in biology, chemistry, and optics. However in practice, the realization of these goals is made difficult by the angular dependence of the sputtering yield and redeposition effects that vary as the topography evolves. An inverse modeling algorithm that optimizes dose profiles, defined as the superposition of time invariant pixel dose profiles (determined from the beam parameters and pixel dwell times), is presented. The response of the target to a set of pixel dwell times in modeled by numerical continuum simulations utilizing 1st and 2nd order sputtering and redeposition, the resulting surfaces are evaluated with respect to a target topography in an error minimization routine. Two algorithms for the parameterization of pixel dwell times are presented, a direct pixel dwell time method, and an abstracted method that uses a refineable piecewise linear cage function to generate pixel dwell times from a minimal number of parameters. The cage function method demonstrates great flexibility and efficiency as compared to the direct fitting method with performance enhancements exceeding ∼10× as compared to direct fitting for medium to large simulation sets. Furthermore, the refineable nature of the cage function enables solutions to adapt to the desired target function. The optimization algorithm, although working with stationary dose profiles, is demonstrated to be applicable also outside the quasi-static approximation. Experimental data confirms the viability of the solutions for 5 × 7 μm deep lens like structures defined by 90 pixel dwell times

Variation-preserving normalization unveils blind spots in gene expression profiling

Science.gov (United States)

Roca, Carlos P.; Gomes, Susana I. L.; Amorim, Mónica J. B.; Scott-Fordsmand, Janeck J.

2017-01-01

RNA-Seq and gene expression microarrays provide comprehensive profiles of gene activity, but lack of reproducibility has hindered their application. A key challenge in the data analysis is the normalization of gene expression levels, which is currently performed following the implicit assumption that most genes are not differentially expressed. Here, we present a mathematical approach to normalization that makes no assumption of this sort. We have found that variation in gene expression is much larger than currently believed, and that it can be measured with available assays. Our results also explain, at least partially, the reproducibility problems encountered in transcriptomics studies. We expect that this improvement in detection will help efforts to realize the full potential of gene expression profiling, especially in analyses of cellular processes involving complex modulations of gene expression. PMID:28276435

Image processing and computer controls for video profile diagnostic system in the ground test accelerator (GTA)

International Nuclear Information System (INIS)

Wright, R.; Zander, M.; Brown, S.; Sandoval, D.; Gilpatrick, D.; Gibson, H.

1992-01-01

This paper describes the application of video image processing to beam profile measurements on the Ground Test Accelerator (GTA). A diagnostic was needed to measure beam profiles in the intermediate matching section (IMS) between the radio-frequency quadrupole (RFQ) and the drift tube linac (DTL). Beam profiles are measured by injecting puffs of gas into the beam. The light emitted from the beam-gas interaction is captured and processed by a video image processing system, generating the beam profile data. A general purpose, modular and flexible video image processing system, imagetool, was used for the GTA image profile measurement. The development of both software and hardware for imagetool and its integration with the GTA control system (GTACS) is discussed. The software includes specialized algorithms for analyzing data and calibrating the system. The underlying design philosophy of imagetool was tested by the experience of building and using the system, pointing the way for future improvements. (Author) (3 figs., 4 refs.)

RASS sound speed profile (SSP) measurements for use in outdoor sound propagation models

Energy Technology Data Exchange (ETDEWEB)

Bradley, S G [Physics Department, University of Auckland (New Zealand); Huenerbein, S v; Waddington, D [Research Institute for the Built and Human Environment, University of Salford (United Kingdom)], E-mail: s.vonhunerbein@salford.ac.uk

2008-05-01

The performance of outdoor sound propagation models depends to a great extent on meteorological input parameters. In an effort to improve speed and accuracy, model output synthetic sound speed profiles (SSP) are commonly used depending on meteorological classification schemes. In order to use SSP measured by RASS in outdoor sound propagation models, the complex profiles need to be simplified. In this paper we extend an investigation on the spatial and temporal characteristics of the meteorological data set required to yield adequate comparisons between models and field measurements, so that the models can be fairly judged. Vertical SSP from RASS, SODAR wind profiles as well as mast wind and temperature data from a flat terrain site and measured over a period of several months are used to evaluate applicability of the logarithmic approximation for a stability classification scheme proposed by the HARMONOISE working group.

RASS sound speed profile (SSP) measurements for use in outdoor sound propagation models

International Nuclear Information System (INIS)

Bradley, S G; Huenerbein, S v; Waddington, D

2008-01-01

The performance of outdoor sound propagation models depends to a great extent on meteorological input parameters. In an effort to improve speed and accuracy, model output synthetic sound speed profiles (SSP) are commonly used depending on meteorological classification schemes. In order to use SSP measured by RASS in outdoor sound propagation models, the complex profiles need to be simplified. In this paper we extend an investigation on the spatial and temporal characteristics of the meteorological data set required to yield adequate comparisons between models and field measurements, so that the models can be fairly judged. Vertical SSP from RASS, SODAR wind profiles as well as mast wind and temperature data from a flat terrain site and measured over a period of several months are used to evaluate applicability of the logarithmic approximation for a stability classification scheme proposed by the HARMONOISE working group

Application of PLC technology in measurement of beam profile on 100 MeV accelerator

International Nuclear Information System (INIS)

Yu Luyang; Chinese Academy of Sciences, Beijing; Chen Yongzhong; Chen Yongzhong; Liu Dekang; Chinese Academy of Sciences, Beijing

2005-01-01

A comprehensive introduction is given to the real-time measuring method, which is based on the Programmable Logic Controller (PLC) technology and can measure intensity and profile of the beam by a scintillator screen. The whole system has many advantages, such as good reliability, high precision, intuitional measurement, etc. due to the use of the PLC and Labview software. (authors)

Response function during oxygen sputter profiling and its application to deconvolution of ultrashallow B depth profiles in Si

International Nuclear Information System (INIS)

Shao Lin; Liu Jiarui; Wang Chong; Ma, Ki B.; Zhang Jianming; Chen, John; Tang, Daniel; Patel, Sanjay; Chu Weikan

2003-01-01

The secondary ion mass spectrometry (SIMS) response function to a B 'δ surface layer' has been investigated. Using electron-gun evaporation combined with liquid nitrogen cooling of target, we are able to deposit an ultrathin B layer without detectable island formation. The B spatial distribution obtained from SIMS is exponentially decaying with a decay length approximately a linear function of the incident energy of the oxygen during the SIMS analysis. Deconvolution with the response function has been applied to reconstruct the spatial distribution of ultra-low-energy B implants. A correction to depth and yield scales due to transient sputtering near the Si surface region was also applied. Transient erosion shifts the profile shallower, but beam mixing shifts it deeper. These mutually compensating effects make the adjusted distribution almost the same as original data. The one significant difference is a buried B peak observed near the surface region

TOURIST PROFILE OF YOUNG-ADULTS IN MACEDONIA AND THEIR PERCEPTION OF E-TOOLS

Directory of Open Access Journals (Sweden)

Biljana Petrevska

2013-01-01

Full Text Available The paper intends to create a tourist profile of young-adult consumers as well as to examine their attitude towards e-tools. More precisely, the study examines how young people percept the Internet as rapidly evolving medium, and do they use the on-line social networks (OSN in sharing experiences. In both cases, the main research area is tourism and travel. So, the aim and objective of the paper are to determine a tourist profile among young population in Macedonia and simultaneously to determine the level of application of e-tools. For this purpose, a survey was conducted among undergraduate students. The results point to interesting conclusions regarding travel habits and interests, planning activities, type of accommodation, preferences and other data that support the created tourist profile. With regards to research hypotheses, the outcomes confirm solid causality between tested variables concluding that young population in Macedonia use e-tools for travel and tourism purposes. Such findings one may find useful for tailoring strategies to the specific characteristics and initially created tourist profile of young consumers in Macedonia.

TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models

Science.gov (United States)

Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

2016-05-01

Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com.

TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models.

Science.gov (United States)

Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

2016-05-01

Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com .

Resistive evolution of current profile in tokamaks, application to the optimization of Tore-supra plasma discharges; Evolution resistive du profil de courant dans les Tokamaks, application a l'optimisation des decharges de Tore Supra

Energy Technology Data Exchange (ETDEWEB)

Bregeon, R

1999-03-01

In Tokamak plasma physics, current profile shaping has now become a key issue to improve the confinement properties of the plasma discharge. The objective of this work is to study the processes governing the current diffusion when non-inductive current are playing a major role in the discharge. Ultimately, this study aims to identify the key parameters to control the plasma current density profile with external current drive heating systems such as Lower Hybrid Current drive (LHCD) or self generated current drive such as the bootstrap current. Principles of non inductive current drive and heating systems are introduced as well as bootstrap current mechanisms. Then we present the experimental study of plasma parallel electric conductivity to validate existing models. Using these results, the poloidal magnetic field flux diffusion is modelled, using toroidal co-ordinates in order to give an accurate description of the current density profiles evolution. The initial and boundary conditions required for numerical resolution of the diffusion equation are also presented. Finally, we conclude this work with the simulations of two discharges: one with Fast Wave Electron Heating and the second using Lower Hybrid Current Drive. These simulations have multiples aims: validity test of our numerical tool and to show some limits of cylindrical models. Test of electric conductivity and bootstrap current models. To identify the key parameters involved in the current diffusion processes of a high performance plasma discharge on Tore Supra. Such simulations are crucial to determine the amount of non-inductive current required to control and sustain long plasma discharges in steady state. (author)

The admissibility of offender profiling in courtroom: a review of legal issues and court opinions.

Science.gov (United States)

Bosco, Dario; Zappalà, Angelo; Santtila, Pekka

2010-01-01

What is the future of Offender Profiling? Is it an important field of forensic science or is it only a glamorous art? After the trilogy "Daubert-Joiner-Kumho" and after the last version, in 2009, of the Federal Rules of Evidence (F.R.E.), the opinion of American Courts concerning the admissibility of scientific evidence has changed, and the questions above can now have new answers. The change is closely tied to the perceived difference between hard and soft sciences and, in this way, the new gatekeeping role of the Courts also concerns whether offender profiling can be regarded as scientific evidence and if offender profiling should be admitted in the Courtroom as scientific evidence. In this work we present a comprehensive review concerning the most important Court opinions in U.S.A, U.K., Canada and Australia, about reliability and admissibility of offender profiling, in its different forensic application, as scientific evidence, and we suggest how and when an expert witness in the field of offender profiling can, in the light of these opinions, be admitted in Court.

Dose profile study in head CT scans using radiochromic films

International Nuclear Information System (INIS)

Ladino G, A. M.; Prata M, A.

2016-10-01

Diagnostic images of computed tomography generate higher doses than other methods of diagnostic radiology using X-ray beam attenuation. Clinical applications of CT have been increased by technological advances, what leads to a wide variety of scanner in the Brazilian technological pool. It has been difficult to implement dose reduction strategies because of the lack of proper guidance on computed tomography examinations. However, CT scanners allow adjusting acquisition parameter according to the patients physical profile and diagnostic application for which the scan is intended. The knowledge of the dose distribution is important because changes in image acquisition parameters may provide dose reduction. In this study, it was used a cylindrical head phantom in PMMA with 5 openings, what allows dose measurement in 5 regions. In a GE CT scanner, Discovery model of 64 channels, the central slice of the head phantom was irradiated and the absorbed doses were measured using a pencil ionization chamber. Radiochromic film strips were placed in the peripheral and in the central region of the head phantom and was performed a scan of 10 cm in the phantom central region. The scan was performed using the head scanning protocol of the radiobiology service, with a voltage of 120 kV. After scanning, the radiochromic film strips were digitalized and their digital images were used to have the dose longitudinal profiles. The dose values recorded have variation in a range of 18.66 to 23.57 mGy. In the results it was compared the dose index values obtained by the pencil chamber measurement to the dose longitudinal profiles recorded by the film strips. (Author)

Dose profile study in head CT scans using radiochromic films

Energy Technology Data Exchange (ETDEWEB)

Ladino G, A. M.; Prata M, A., E-mail: amlgphys@gmail.com [Universidade Federal de Minas Gerais, Departamento de Engenharia Nuclear, Av. Pte. Antonio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais (Brazil)

2016-10-15

Diagnostic images of computed tomography generate higher doses than other methods of diagnostic radiology using X-ray beam attenuation. Clinical applications of CT have been increased by technological advances, what leads to a wide variety of scanner in the Brazilian technological pool. It has been difficult to implement dose reduction strategies because of the lack of proper guidance on computed tomography examinations. However, CT scanners allow adjusting acquisition parameter according to the patients physical profile and diagnostic application for which the scan is intended. The knowledge of the dose distribution is important because changes in image acquisition parameters may provide dose reduction. In this study, it was used a cylindrical head phantom in PMMA with 5 openings, what allows dose measurement in 5 regions. In a GE CT scanner, Discovery model of 64 channels, the central slice of the head phantom was irradiated and the absorbed doses were measured using a pencil ionization chamber. Radiochromic film strips were placed in the peripheral and in the central region of the head phantom and was performed a scan of 10 cm in the phantom central region. The scan was performed using the head scanning protocol of the radiobiology service, with a voltage of 120 kV. After scanning, the radiochromic film strips were digitalized and their digital images were used to have the dose longitudinal profiles. The dose values recorded have variation in a range of 18.66 to 23.57 mGy. In the results it was compared the dose index values obtained by the pencil chamber measurement to the dose longitudinal profiles recorded by the film strips. (Author)

Numerical Evaluation of Parameter Correlation in the Hartmann-Tran Line Profile

Science.gov (United States)

Adkins, Erin M.; Reed, Zachary; Hodges, Joseph T.

2017-06-01

The partially correlated quadratic, speed-dependent hard-collision profile (pCqSDHCP), for simplicity referred to as the Hartmann-Tran profile (HTP), has been recommended as a generalized lineshape for high resolution spectroscopy. The HTP parameterizes complex collisional effects such as Dicke narrowing, speed dependent narrowing, and correlations between velocity-changing and dephasing collisions, while also simplifying to simpler profiles that are widely used, such as the Voigt profile. As advanced lineshape profiles are adopted by more researchers, it is important to understand the limitations that data quality has on the ability to retrieve physically meaningful parameters using sophisticated lineshapes that are fit to spectra of finite signal-to-noise ratio. In this work, spectra were simulated using the HITRAN Application Programming Interface (HAPI) across a full range of line parameters. Simulated spectra were evaluated to quantify the precision with which fitted lineshape parameters can be determined at a given signal-to-noise ratio, focusing on the numerical correlation between the retrieved Dicke narrowing frequency and the velocity-changing and dephasing collisions correlation parameter. Tran, H., N. Ngo, and J.-M. Hartmann, Journal of Quantitative Spectroscopy and Radiative Transfer 2013. 129: p. 89-100. Tennyson, et al., Pure Appl. Chem. 2014, 86: p. 1931-1943. Kochanov, R.V., et al., Journal of Quantitative Spectroscopy and Radiative Transfer 2016. 177: p. 15-30. Tran, H., N. Ngo, and J.-M. Hartmann, Journal of Quantitative Spectroscopy and Radiative Transfer 2013. 129: p. 199-203.

Oral and intramuscular application of cyanogenic glycoside amygdalin did not induce changes in haematological profile of male rabbits

Directory of Open Access Journals (Sweden)

Katarína Zbyňovská

2017-01-01

Full Text Available Amygdalin is a cyanogenic glycoside initially obtained from the seeds of bitter almonds. It is composed of one molecule of benzaldehyde, two molecules of glucose and one molecule of hydrocyanic acid. Various ways of amygdalin application play a different role in recipient organism. Intravenous infusion of amygdalin produced neither cyanidemia nor signs of toxicity, but oral administration resulted in significant blood cyanide levels. The present in vivo study was designed to reveal whether amygdalin is able to cause changes in the haematological profile and thus alter the physiological functions, using rabbits as a biological model. Adult male rabbits (n = 20 were randomly divided into five groups: the control group without any amygdalin administration, two experimental groups received a daily intramuscular injection of amygdalin at a dose 0.6 and 3.0 mg.kg-1 b.w. and other two groups were fed by crushed apricot seeds at dose 60 and 300 mg. kg-1 b.w., mixed with commercial feed over the period of 14 days. After two weeks, haematological parameters in whole blood were analysed (WBC - total white blood cell count, LYM - lymphocytes count, MID - medium size cell count, GRA - granulocytes count, RBC - red blood cell count, HGB - haemoglobin, HCT - haematocrit, MCV - mean corpuscular volume, MCH - mean corpuscular hemoglobin, MCHC - mean corpuscular hemoglobin concentration, RDWc - red cell distribution width, PLT - platelet count, PCT - platelet percentage, MPV - mean platelet volume, PDWc - platelet distribution width using haematology analyser Abacus junior VET. Our findings indicate that intramuscular and oral application of amygdalin for two weeks did not significantly affect the haematology parameters in experimental animals. In this study, no obvious beneficial or negative effects of amygdalin administration on the blood of male rabbits were observed.

An Object-Oriented Information Model for Policy-based Management of Distributed Applications

NARCIS (Netherlands)

Diaz, G.; Gay, V.C.J.; Horlait, E.; Hamza, M.H.

2002-01-01

This paper presents an object-oriented information model to support a policy-based management for distributed multimedia applications. The information base contains application-level information about the users, the applications, and their profile. Our Information model is described in details and

A Service Oriented Web Application for Learner Knowledge Representation, Management and Sharing Conforming to IMS LIP

Science.gov (United States)

Lazarinis, Fotis

2014-01-01

iLM is a Web based application for representation, management and sharing of IMS LIP conformant user profiles. The tool is developed using a service oriented architecture with emphasis on the easy data sharing. Data elicitation from user profiles is based on the utilization of XQuery scripts and sharing with other applications is achieved through…

New non-cognitive procedures for medical applicant selection: a qualitative analysis in one school.

Science.gov (United States)

Katz, Sara; Vinker, Shlomo

2014-11-07

Recent data have called into question the reliability and predictive validity of standard admission procedures to medical schools. Eliciting non-cognitive attributes of medical school applicants using qualitative tools and methods has thus become a major challenge. 299 applicants aged 18-25 formed the research group. A set of six research tools was developed in addition to the two existing ones. These included: a portfolio task, an intuitive task, a cognitive task, a personal task, an open self-efficacy questionnaire and field-notes. The criteria-based methodology design used constant comparative analysis and grounded theory techniques to produce a personal attributes profile per participant, scored on a 5-point scale holistic rubric. Qualitative validity of data gathering was checked by comparing the profiles elicited from the existing interview against the profiles elicited from the other tools, and by comparing two profiles of each of the applicants who handed in two portfolio tasks. Qualitative validity of data analysis was checked by comparing researcher results with those of an external rater (n =10). Differences between aggregated profile groups were checked by the Npar Wilcoxon Signed Ranks Test and by Spearman Rank Order Correlation Test. All subjects gave written informed consent to their participation. Privacy was protected by using code numbers. A concept map of 12 personal attributes emerged, the core constructs of which were motivation, sociability and cognition. A personal profile was elicited. Inter-rater agreement was 83.3%. Differences between groups by aggregated profiles were found significant (p < .05, p < .01, p < .001).A random sample of sixth year students (n = 12) underwent the same admission procedure as the research group. Rank order was different; and arrogance was a new construct elicited in the sixth year group. This study suggests a broadening of the methodology for selecting medical school applicants. This methodology

Polar measurements on profiles

Energy Technology Data Exchange (ETDEWEB)

Althaus, D.

1985-03-01

Wind tunnel models with a profile depth of t=0.5 m were measured in a laminar wind tunnel by the usual measuring processes. The profile resistance was determined by integration along the width of span. The smooth profiles were examined at Re=0.7/1.0 and 1.5 million. At Re=1.0 million, the position of the changeover points were determined with a stethoscope. Also at this Reynolds number measurements were taken with a trip wire of d=2 mm diameter, directly on the profile nose. The tables contain the co-ordinates of the profiles, the contours, the theoretical speed distributions for 4 different angles of attack, the csub(a)-csub(w) polar measurements and changeover points, and the torque coefficients around the t/4 point. (BR).

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure.

Science.gov (United States)

Orlenko, Alena; Moore, Jason H; Orzechowski, Patryk; Olson, Randal S; Cairns, Junmei; Caraballo, Pedro J; Weinshilboum, Richard M; Wang, Liewei; Breitenstein, Matthew K

2018-01-01

With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic profiling endeavors, where potentially thousands of independent data points must be evaluated. In previous research, AutoML using high-dimensional data of varying types has been demonstrably robust, outperforming traditional approaches. However, considerations for application in clinical metabolic profiling remain to be evaluated. Particularly, regarding the robustness of AutoML to identify and adjust for common clinical confounders. In this study, we present a focused case study regarding AutoML considerations for using the Tree-Based Optimization Tool (TPOT) in metabolic profiling of exposure to metformin in a biobank cohort. First, we propose a tandem rank-accuracy measure to guide agnostic feature selection and corresponding threshold determination in clinical metabolic profiling endeavors. Second, while AutoML, using default parameters, demonstrated potential to lack sensitivity to low-effect confounding clinical covariates, we demonstrated residual training and adjustment of metabolite features as an easily applicable approach to ensure AutoML adjustment for potential confounding characteristics. Finally, we present increased homocysteine with long-term exposure to metformin as a potentially novel, non-replicated metabolite association suggested by TPOT; an association not identified in parallel clinical metabolic profiling endeavors. While warranting independent replication, our tandem rank-accuracy measure suggests homocysteine to be the metabolite feature with largest effect, and corresponding priority for further translational clinical research. Residual training and adjustment for a potential confounding effect by BMI only slightly modified

Domain-oriented functional analysis based on expression profiling

Directory of Open Access Journals (Sweden)

Greene Jonathan

2002-10-01

Full Text Available Abstract Background Co-regulation of genes may imply involvement in similar biological processes or related function. Many clusters of co-regulated genes have been identified using microarray experiments. In this study, we examined co-regulated gene families using large-scale cDNA microarray experiments on the human transcriptome. Results We present a simple model, which, for each probe pair, distills expression changes into binary digits and summarizes the expression of multiple members of a gene family as the Family Regulation Ratio. The set of Family Regulation Ratios for each protein family across multiple experiments is called a Family Regulation Profile. We analyzed these Family Regulation Profiles using Pearson Correlation Coefficients and derived a network diagram portraying relationships between the Family Regulation Profiles of gene families that are well represented on the microarrays. Our strategy was cross-validated with two randomly chosen data subsets and was proven to be a reliable approach. Conclusion This work will help us to understand and identify the functional relationships between gene families and the regulatory pathways in which each family is involved. Concepts presented here may be useful for objective clustering of protein functions and deriving a comprehensive protein interaction map. Functional genomic approaches such as this may also be applicable to the elucidation of complex genetic regulatory networks.

Profiling cancer

DEFF Research Database (Denmark)

Ciro, Marco; Bracken, Adrian P; Helin, Kristian

2003-01-01

In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and prediction of patient survival. In addition to promising a more accurate classification of cancer and therefore better treatment of patients......, gene-expression profiling can result in the identification of novel potential targets for cancer therapy and a better understanding of the molecular mechanisms leading to cancer....

Fiber optic interferometry for industrial process monitoring and control applications

Science.gov (United States)

Marcus, Michael A.

2002-02-01

Over the past few years we have been developing applications for a high-resolution (sub-micron accuracy) fiber optic coupled dual Michelson interferometer-based instrument. It is being utilized in a variety of applications including monitoring liquid layer thickness uniformity on coating hoppers, film base thickness uniformity measurement, digital camera focus assessment, optical cell path length assessment and imager and wafer surface profile mapping. The instrument includes both coherent and non-coherent light sources, custom application dependent optical probes and sample interfaces, a Michelson interferometer, custom electronics, a Pentium-based PC with data acquisition cards and LabWindows CVI or LabView based application specific software. This paper describes the development evolution of this instrument platform and applications highlighting robust instrument design, hardware, software, and user interfaces development. The talk concludes with a discussion of a new high-speed instrument configuration, which can be utilized for high speed surface profiling and as an on-line web thickness gauge.

A statistical approach for predicting thermal diffusivity profiles in fusion plasmas as a transport model

International Nuclear Information System (INIS)

Yokoyama, Masayuki

2014-01-01

A statistical approach is proposed to predict thermal diffusivity profiles as a transport “model” in fusion plasmas. It can provide regression expressions for the ion and electron heat diffusivities (χ i and χ e ), separately, to construct their radial profiles. An approach that this letter is proposing outstrips the conventional scaling laws for the global confinement time (τ E ) since it also deals with profiles (temperature, density, heating depositions etc.). This approach has become possible with the analysis database accumulated by the extensive application of the integrated transport analysis suite to experiment data. In this letter, TASK3D-a analysis database for high-ion-temperature (high-T i ) plasmas in the LHD (Large Helical Device) is used as an example to describe an approach. (author)

Application of wind-profiling radar data to the analysis of dust weather in the Taklimakan Desert.

Science.gov (United States)

Wang, Minzhong; Wei, Wenshou; Ruan, Zheng; He, Qing; Ge, Runsheng

2013-06-01

The Urumqi Institute of Desert Meteorology of the China Meteorological Administration carried out an atmospheric scientific experiment to detect dust weather using a wind-profiling radar in the hinterland of the Taklimakan Desert in April 2010. Based on the wind-profiling data obtained from this experiment, this paper seeks to (a) analyze the characteristics of the horizontal wind field and vertical velocity of a breaking dust weather in a desert hinterland; (b) calculate and give the radar echo intensity and vertical distribution of a dust storm, blowing sand, and floating dust weather; and (c) discuss the atmosphere dust counts/concentration derived from the wind-profiling radar data. Studies show that: (a) A wind-profiling radar is an upper-air atmospheric remote sensing system that effectively detects and monitors dust. It captures the beginning and ending of a dust weather process as well as monitors the sand and dust being transported in the air in terms of height, thickness, and vertical intensity. (b) The echo intensity of a blowing sand and dust storm weather episode in Taklimakan is about -1~10 dBZ while that of floating dust -1~-15 dBZ, indicating that the dust echo intensity is significantly weaker than that of precipitation but stronger than that of clear air. (c) The vertical shear of horizontal wind and the maintenance of low-level east wind are usually dynamic factors causing a dust weather process in Taklimakan. The moment that the low-level horizontal wind field finds a shear over time, it often coincides with the onset of a sand blowing and dust storm weather process. (d) When a blowing sand or dust storm weather event occurs, the atmospheric vertical velocity tends to be of upward motion. This vertical upward movement of the atmosphere supported with a fast horizontal wind and a dry underlying surface carries dust particles from the ground up to the air to form blown sand or a dust storm.

Integral Analysis of Seismic Refraction and Ambient Vibration Survey for Subsurface Profile Evaluation

Science.gov (United States)

Hazreek, Z. A. M.; Kamarudin, A. F.; Rosli, S.; Fauziah, A.; Akmal, M. A. K.; Aziman, M.; Azhar, A. T. S.; Ashraf, M. I. M.; Shaylinda, M. Z. N.; Rais, Y.; Ishak, M. F.; Alel, M. N. A.

2018-04-01

Geotechnical site investigation as known as subsurface profile evaluation is the process of subsurface layer characteristics determination which finally used for design and construction phase. Traditionally, site investigation was performed using drilling technique thus suffers from several limitation due to cost, time, data coverage and sustainability. In order to overcome those problems, this study adopted surface techniques using seismic refraction and ambient vibration method for subsurface profile depth evaluation. Seismic refraction data acquisition and processing was performed using ABEM Terraloc and OPTIM software respectively. Meanwhile ambient vibration data acquisition and processing was performed using CityShark II, Lennartz and GEOPSY software respectively. It was found that studied area consist of two layers representing overburden and bedrock geomaterials based on p-wave velocity value (vp = 300 – 2500 m/s and vp > 2500 m/s) and natural frequency value (Fo = 3.37 – 3.90 Hz) analyzed. Further analysis found that both methods show some good similarity in term of depth and thickness with percentage accuracy at 60 – 97%. Consequently, this study has demonstrated that the application of seismic refractin and ambient vibration method was applicable in subsurface profile depth and thickness estimation. Moreover, surface technique which consider as non-destructive method adopted in this study was able to compliment conventional drilling method in term of cost, time, data coverage and environmental sustainaibility.

Low profile, low cost, new geometry integrated inductors

DEFF Research Database (Denmark)

Ouyang, Ziwei; Thomsen, Ole Cornelius; Andersen, Michael A. E.

2011-01-01

windings with well-defined thickness. Many advantages and disadvantages are described in depth. In this work, inverse coupling and direct coupling in the new geometry integrated inductors have been analyzed. Coupling characteristic caused by a special saturation behavior has been emphasis. And also...... variable inductors caused by the special saturation behavior may be utilized in some applications. The new integrated inductors make it possible to build low-profile, low-cost, flexibility DC/DC converters, and it can be extensively designed for the low-voltage and high-current required by the modern...

Evaluation of vertical profiles to design continuous descent approach procedure

Science.gov (United States)

Pradeep, Priyank

The current research focuses on predictability, variability and operational feasibility aspect of Continuous Descent Approach (CDA), which is among the key concepts of the Next Generation Air Transportation System (NextGen). The idle-thrust CDA is a fuel economical, noise and emission abatement procedure, but requires increased separation to accommodate for variability and uncertainties in vertical and speed profiles of arriving aircraft. Although a considerable amount of researches have been devoted to the estimation of potential benefits of the CDA, only few have attempted to explain the predictability, variability and operational feasibility aspect of CDA. The analytical equations derived using flight dynamics and Base of Aircraft and Data (BADA) Total Energy Model (TEM) in this research gives insight into dependency of vertical profile of CDA on various factors like wind speed and gradient, weight, aircraft type and configuration, thrust settings, atmospheric factors (deviation from ISA (DISA), pressure and density of the air) and descent speed profile. Application of the derived equations to idle-thrust CDA gives an insight into sensitivity of its vertical profile to multiple factors. This suggests fixed geometric flight path angle (FPA) CDA has higher degree of predictability and lesser variability at the cost of non-idle and low thrust engine settings. However, with optimized design this impact can be overall minimized. The CDA simulations were performed using Future ATM Concept Evaluation Tool (FACET) based on radar-track and aircraft type data (BADA) of the real air-traffic to some of the busiest airports in the USA (ATL, SFO and New York Metroplex (JFK, EWR and LGA)). The statistical analysis of the vertical profiles of CDA shows 1) mean geometric FPAs derived from various simulated vertical profiles are consistently shallower than 3° glideslope angle and 2) high level of variability in vertical profiles of idle-thrust CDA even in absence of

Towards chemical profiling of ignitable liquids with comprehensive two-dimensional gas chromatography: Exploring forensic application to neat white spirits.

Science.gov (United States)

Sampat, Andjoe A S; Lopatka, Martin; Vivó-Truyols, Gabriel; Schoenmakers, Peter J; van Asten, Arian C

2016-10-01

The application of GC×GC-FID and GC×GC-MS for the chemical analysis and profiling of neat white spirit is explored and the benefit of the enhanced peak capacity offered by comprehensive two-dimensional gas chromatography is demonstrated. An extensive sampling exercise was conducted throughout The Netherlands and the production and logistics in terms of bottling and distribution of white spirits were studied. An exploratory approach based on target-peak tables and principal component analysis was employed to study the brand-to-brand differences and production variations over time. Despite the complex chemical composition of white spirit samples this study shows that chemical variation during productions is actually quite limited. Hence care has to be taken with the chemical comparison for forensic purposes. Although some clustering was noticed on brand level, the large scale production process leads to a very consistent composition across stores and brands. However, because of the broad specifications of this commodity product, substantial chemical variation was found over time. This temporal discrimination could be of forensic value when considering white spirits supplies in individual households. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Preliminary study on application of urine amino acids profiling for monitoring of renal tubular injury using GLC-MS

Directory of Open Access Journals (Sweden)

Maja Kazubek-Zemke

2014-11-01

Full Text Available The early diagnosis of the nephrotoxic effect of xenobiotics and drugs is still an unsolved problem. Recent studies suggest a correlation between the nephrotoxic activity of xenobiotics and increased concentration of amino acids in urine. The presented study was focused on the application of GLC-MS method for amino acids profiling in human urine as a noninvasive method for monitoring of kidney condition and tubular injury level.The analytic method is based on the conversion of the amino acids present in the sample to tert-butyldimethylsilyl (TBDMS derivatives and their analysis by gas-liquid chromatography-mass spectrometry (GLC-MS. The procedure of urine sample preparation for chromatographic analysis was optimized.The presence of 12 amino acids in most of the tested healthy human urine samples was detected. The significant differences in the levels of particular amino acids between patients with tubular injury and healthy controls were found, especially for lysine, valine, serine, alanine and leucine (on average 30.0, 7.5, 3.6, 2.9 and 0.5 fold respectively.We found that this approach based on GLC-MS detection can be used in nephrotoxicity studies for urine amino acids monitoring in exposure to xenobiotics and drugs.

Inverse methods for estimating primary input signals from time-averaged isotope profiles

Science.gov (United States)

Passey, Benjamin H.; Cerling, Thure E.; Schuster, Gerard T.; Robinson, Todd F.; Roeder, Beverly L.; Krueger, Stephen K.

2005-08-01

Mammalian teeth are invaluable archives of ancient seasonality because they record along their growth axes an isotopic record of temporal change in environment, plant diet, and animal behavior. A major problem with the intra-tooth method is that intra-tooth isotope profiles can be extremely time-averaged compared to the actual pattern of isotopic variation experienced by the animal during tooth formation. This time-averaging is a result of the temporal and spatial characteristics of amelogenesis (tooth enamel formation), and also results from laboratory sampling. This paper develops and evaluates an inverse method for reconstructing original input signals from time-averaged intra-tooth isotope profiles. The method requires that the temporal and spatial patterns of amelogenesis are known for the specific tooth and uses a minimum length solution of the linear system Am = d, where d is the measured isotopic profile, A is a matrix describing temporal and spatial averaging during amelogenesis and sampling, and m is the input vector that is sought. Accuracy is dependent on several factors, including the total measurement error and the isotopic structure of the measured profile. The method is shown to accurately reconstruct known input signals for synthetic tooth enamel profiles and the known input signal for a rabbit that underwent controlled dietary changes. Application to carbon isotope profiles of modern hippopotamus canines reveals detailed dietary histories that are not apparent from the measured data alone. Inverse methods show promise as an effective means of dealing with the time-averaging problem in studies of intra-tooth isotopic variation.

Gamma-ray scanning of neutron activated geological sediments for studying elemental profile distributions

International Nuclear Information System (INIS)

Ellinger, M.; Janghorbani, M.; Starke, K.

1976-01-01

Gamma-ray scanning for application to elemental profile studies of geological samples was studied with a neutron activated Baltic Shield sediment. Profile distribution of seven elements were measured. The capabilities and limitations of gamma-ray scanning are discussed by comparing the results with profiles obtained after the mechanical subdivision of the sample and the activation of the appropriately sized separates. With respect to the merits and limitations of scanning gamma-ray spectrometry applied to activated complex matrices the following conclusions were drawn. Qualitatively, the scanning method yields the same information as the much more laborious method of mechanical sudbisubdivision. Quantitatively, it is significantly less accurate. The scanning method has the significant advantage of allowing preservation of the sample. This could be important for such speciments as lunar and archeological materials. The method reduces sample preparation time and the possibility of sample contamination. (T.G.)

Lead isotope profiling in dairy calves.

Science.gov (United States)

Buchweitz, John; McClure-Brinton, Kimberly; Zyskowski, Justin; Stensen, Lauren; Lehner, Andreas

2015-03-01

Lead (Pb) is a common cause of heavy metal poisonings in cattle. Sources of Pb on farms include crankcase oil, machinery grease, batteries, plumbing, and paint chips. Consequently, consumption of Pb from these sources may negatively impact animal health and Pb may be inadvertently introduced into the food supply. Therefore, the scope of poisoning incidents must be clearly assessed and sources of intoxication identified and strategies to mitigate exposure evaluated and implemented to prevent future exposures. Stable isotope analysis by inductively-coupled plasma mass spectrometry (ICP-MS) has proven itself of value in forensic investigations. We report on the extension of Pb stable isotope analysis to bovine tissues and profile comparisons with paint chips and soils collected from an affected dairy farm to elucidate the primary source. Pb occurs naturally as four stable isotopes: (204)Pb, (206)Pb, (207)Pb, and (208)Pb. Herein a case is reported to illustrate the use of (207)Pb/(206)Pb and (208)Pb/(206)Pb ratios to link environmental sources of exposure with tissues from a poisoned animal. Chemical Pb profiling provides a valuable tool for field investigative approaches to Pb poisoning in production agriculture and is applicable to subclinical exposures. Copyright © 2014 Elsevier Inc. All rights reserved.

Microbial Profiling Of Cyanobacteria From VIT Lake

Directory of Open Access Journals (Sweden)

Swati Singh

2015-08-01

Full Text Available The application of molecular biological methods to study the diversity and ecology of micro-organisms in natural environments has been practice in mid-1980. The aim of our research is to access the diversity composition and functioning of complex microbial community found in VIT Lake. Molecular ecology is a new field in which microbes can be recognized and their function can be understood at the DNA or RNA level which is useful for constructing genetically modified microbes by recombinant DNA technology for reputed use in the environment. In this research first we will isolate cyanobacteria in lab using conventional methods like broth culture and spread plate method then we will analyze their morphology using various staining methods and DNA and protein composition using electrophoresis method. The applications of community profiling approaches will advance our understanding of the functional role of microbial diversity in VIT Lake controls on microbial community composition.

Beam profile measurements on RHIC

International Nuclear Information System (INIS)

Connolly, R.; Michnoff, R.; Moore, T.; Shea, T.; Tepikian, S.

2000-01-01

The Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Lab was commissioned during the summer of 1999. Transverse beam profiles on RHIC are measured with ionization profile monitors (IPMs). An IPM measures beam profiles by collecting the electrons liberated by residual gas ionization by the beam. The detector is placed in the gap of a dipole magnet to force the electrons to travel in straight lines from the beamline center to the collector. One IPM was tested and it measured the profiles of a single gold bunch containing 10 8 ions on consecutive turns. We show an example of one of these profiles giving transverse emittance. Also several profiles are combined into a mountain-range plot which shows betatron oscillations at injection

Using radar wind profilers and RASS data to calculate power plant plume rise and transport

International Nuclear Information System (INIS)

Ping, Y.J.; Gaynor, J.E.

1994-01-01

As the number of 915-MHz radar wind profilers and radio acoustic sounding systems (RASS) increases, their number of uses also increases. These systems have demonstrated particular utility in air quality studies and, more specifically, in complex terrain. One data set from the radar profilers that has not, to date, been utilized to any large extent is represented by the temperature profiles derived from the RASS. Normally, these profiles represent a 5-min average every hour with a height resolution of about 60 m, a minimum range of about 100 m, and a maximum range of about 1.5 km, although this varies substantially with meterological conditions. Such profiles have several potential applications. Among them are determinations of mixing height and stability. In this work, we use the stability, along with the hour-averaged wind profiles, to estimate plume rise heights at a power plant site in Laughlin, Nevada, about 200 km south of Lake Mead. The profiles are first stratified according to season and synoptic categories so that the calculated plume rise heights could be separated by background transport conditions. The data were taken during Project Measurement of Haze and Visual Effects (MOHAVE), which took place in 1992. This project is briefly discussed in the next section, along with the instrumentation and data used in this study

Using radar wind profilers and RASS data to calculate power plant plume rise and transport

Energy Technology Data Exchange (ETDEWEB)

Ping, Y.J. [Univ. of Colorado, Boulder, CO (United States); Gaynor, J.E. [NOAA/ERL Wave Propagation Lab., Boulder, CO (United States)

1994-12-31

As the number of 915-MHz radar wind profilers and radio acoustic sounding systems (RASS) increases, their number of uses also increases. These systems have demonstrated particular utility in air quality studies and, more specifically, in complex terrain. One data set from the radar profilers that has not, to date, been utilized to any large extent is represented by the temperature profiles derived from the RASS. Normally, these profiles represent a 5-min average every hour with a height resolution of about 60 m, a minimum range of about 100 m, and a maximum range of about 1.5 km, although this varies substantially with meterological conditions. Such profiles have several potential applications. Among them are determinations of mixing height and stability. In this work, we use the stability, along with the hour-averaged wind profiles, to estimate plume rise heights at a power plant site in Laughlin, Nevada, about 200 km south of Lake Mead. The profiles are first stratified according to season and synoptic categories so that the calculated plume rise heights could be separated by background transport conditions. The data were taken during Project Measurement of Haze and Visual Effects (MOHAVE), which took place in 1992. This project is briefly discussed in the next section, along with the instrumentation and data used in this study.

Implicit User Interest Profile

CERN Document Server

Chan, K

2002-01-01

User interest profile presents items that the users are interested in. Typically those items can be listed or grouped. Listing is good but it does not possess interests at different abstraction levels - the higher-level interests are more general, while the lower-level ones are more specific. Furthermore, more general interests, in some sense, correspond to longer-term interests, while more specific interests correspond to shorter-term interests. This hierarchical user interest profile has obvious advantages: specifying user's specific interests and general interests and representing their relationships. Current user interest profile structures mostly do not use implicit method, nor use an appropriate clustering algorithm especially for conceptually hierarchical structures. This research studies building a hierarchical user interest profile (HUIP) and the hierarchical divisive algorithm (HDC). Several users visit hundreds of web pages and each page is recorded in each users profile. These web pages are used t...

Convolution based profile fitting

International Nuclear Information System (INIS)

Kern, A.; Coelho, A.A.; Cheary, R.W.

2002-01-01

Full text: In convolution based profile fitting, profiles are generated by convoluting functions together to form the observed profile shape. For a convolution of 'n' functions this process can be written as, Y(2θ)=F 1 (2θ)x F 2 (2θ)x... x F i (2θ)x....xF n (2θ). In powder diffractometry the functions F i (2θ) can be interpreted as the aberration functions of the diffractometer, but in general any combination of appropriate functions for F i (2θ) may be used in this context. Most direct convolution fitting methods are restricted to combinations of F i (2θ) that can be convoluted analytically (e.g. GSAS) such as Lorentzians, Gaussians, the hat (impulse) function and the exponential function. However, software such as TOPAS is now available that can accurately convolute and refine a wide variety of profile shapes numerically, including user defined profiles, without the need to convolute analytically. Some of the most important advantages of modern convolution based profile fitting are: 1) virtually any peak shape and angle dependence can normally be described using minimal profile parameters in laboratory and synchrotron X-ray data as well as in CW and TOF neutron data. This is possible because numerical convolution and numerical differentiation is used within the refinement procedure so that a wide range of functions can easily be incorporated into the convolution equation; 2) it can use physically based diffractometer models by convoluting the instrument aberration functions. This can be done for most laboratory based X-ray powder diffractometer configurations including conventional divergent beam instruments, parallel beam instruments, and diffractometers used for asymmetric diffraction. It can also accommodate various optical elements (e.g. multilayers and monochromators) and detector systems (e.g. point and position sensitive detectors) and has already been applied to neutron powder diffraction systems (e.g. ANSTO) as well as synchrotron based

Estimating Planetary Boundary Layer Heights from NOAA Profiler Network Wind Profiler Data

Science.gov (United States)

Molod, Andrea M.; Salmun, H.; Dempsey, M

2015-01-01

An algorithm was developed to estimate planetary boundary layer (PBL) heights from hourly archived wind profiler data from the NOAA Profiler Network (NPN) sites located throughout the central United States. Unlike previous studies, the present algorithm has been applied to a long record of publicly available wind profiler signal backscatter data. Under clear conditions, summertime averaged hourly time series of PBL heights compare well with Richardson-number based estimates at the few NPN stations with hourly temperature measurements. Comparisons with clear sky reanalysis based estimates show that the wind profiler PBL heights are lower by approximately 250-500 m. The geographical distribution of daily maximum PBL heights corresponds well with the expected distribution based on patterns of surface temperature and soil moisture. Wind profiler PBL heights were also estimated under mostly cloudy conditions, and are generally higher than both the Richardson number based and reanalysis PBL heights, resulting in a smaller clear-cloudy condition difference. The algorithm presented here was shown to provide a reliable summertime climatology of daytime hourly PBL heights throughout the central United States.

Reliability Assessment of Transformerless PV Inverters considering Mission Profiles

Directory of Open Access Journals (Sweden)

Yongheng Yang

2015-01-01

Full Text Available Due to the small volume and high efficiency, transformerless inverters have gained much popularity in grid-connected PV applications, where minimizing leakage current injection is mandatory. This can be achieved by either modifying the modulation schemes or adding extra power switching devices, resulting in an uneven distribution of the power losses on the switching devices. Consequently, the device thermal loading is redistributed and thus may alter the entire inverter reliability performance, especially under a long-term operation. In this consideration, this paper assesses the device reliability of three transformerless inverters under a yearly mission profile (i.e., solar irradiance and ambient temperature. The mission profile is translated to device thermal loading, which is used for lifetime prediction. Comparison results reveal the lifetime mismatches among the power switching devices operating under the same condition, which offers new thoughts for a robust design and a reliable operation of grid-connected transformerless PV inverters with high efficiency.

A Numerical Fit of Analytical to Simulated Density Profiles in Dark Matter Haloes

Science.gov (United States)

Caimmi, R.; Marmo, C.; Valentinuzzi, T.

2005-06-01

Analytical and geometrical properties of generalized power-law (GPL) density profiles are investigated in detail. In particular, a one-to-one correspondence is found between mathematical parameters (a scaling radius, r_0, a scaling density, rho_0, and three exponents, alpha, beta, gamma), and geometrical parameters (the coordinates of the intersection of the asymptotes, x_C, y_C, and three vertical intercepts, b, b_beta, b_gamma, related to the curve and the asymptotes, respectively): (r_0,rho_0,alpha,beta,gamma) (x_C,y_C,b,b_beta,b_gamma). Then GPL density profiles are compared with simulated dark haloes (SDH) density profiles, and nonlinear least-absolute values and least-squares fits involving the above mentioned five parameters (RFSM5 method) are prescribed. More specifically, the sum of absolute values or squares of absolute logarithmic residuals, R_i= log rhoSDH(r_i)-log rhoGPL(r_i), is evaluated on 10^5 points making a 5- dimension hypergrid, through a few iterations. The size is progressively reduced around a fiducial minimum, and superpositions on nodes of earlier hypergrids are avoided. An application is made to a sample of 17 SDHs on the scale of cluster of galaxies, within a flat LambdaCDM cosmological model (Rasia et al. 2004). In dealing with the mean SDH density profile, a virial radius, rvir, averaged over the whole sample, is assigned, which allows the calculation of the remaining parameters. Using a RFSM5 method provides a better fit with respect to other methods. The geometrical parameters, averaged over the whole sample of best fitting GPL density profiles, yield (alpha,beta,gamma) approx(0.6,3.1,1.0), to be compared with (alpha,beta,gamma)=(1,3,1), i.e. the NFW density profile (Navarro et al. 1995, 1996, 1997), (alpha,beta,gamma)=(1.5,3,1.5) (Moore et al. 1998, 1999), (alpha,beta,gamma)=(1,2.5,1) (Rasia et al. 2004); and, in addition, gamma approx 1.5 (Hiotelis 2003), deduced from the application of a RFSM5 method, but using a different

Evaluation of a new high-dimensional miRNA profiling platform

Directory of Open Access Journals (Sweden)

Lamblin Anne-Francoise

2009-08-01

Full Text Available Abstract Background MicroRNAs (miRNAs are a class of approximately 22 nucleotide long, widely expressed RNA molecules that play important regulatory roles in eukaryotes. To investigate miRNA function, it is essential that methods to quantify their expression levels be available. Methods We evaluated a new miRNA profiling platform that utilizes Illumina's existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amounts of input RNA. The beta test version was comprised of 735 miRNA targets of Illumina's miRNA profiling application. Results Reproducibility between sample replicates within a plate was good (Spearman's correlation 0.91 to 0.98 as was the plate-to-plate reproducibility replicates run on different days (Spearman's correlation 0.84 to 0.98. To determine whether quality data could be obtained from a broad range of input RNA, data obtained from amounts ranging from 25 ng to 800 ng were compared to those obtained at 200 ng. No effect across the range of RNA input was observed. Conclusion These results indicate that very small amounts of starting material are sufficient to allow sensitive miRNA profiling using the Illumina miRNA high-dimensional platform. Nonlinear biases were observed between replicates, indicating the need for abundance-dependent normalization. Overall, the performance characteristics of the Illumina miRNA profiling system were excellent.

A Feasibility Study of Lead Free Solders for Level 1 Packaging Applications

DEFF Research Database (Denmark)

Chidambaram, Vivek; Hald, John; Hattel, Jesper Henri

2009-01-01

An attempt has been made to determine the lead free ternary combinations that satisfied the solidification requirement for a solder used in level 1 packaging applications, using the CALPHAD approach. The segregation profiles of the promising candidates were analyzed after scrutinizing the equilib......An attempt has been made to determine the lead free ternary combinations that satisfied the solidification requirement for a solder used in level 1 packaging applications, using the CALPHAD approach. The segregation profiles of the promising candidates were analyzed after scrutinizing...

A New Inversion Routine to Produce Vertical Electron-Density Profiles from Ionospheric Topside-Sounder Data

Science.gov (United States)

Wang, Yongli; Benson, Robert F.

2011-01-01

Two software applications have been produced specifically for the analysis of some million digital topside ionograms produced by a recent analog-to-digital conversion effort of selected analog telemetry tapes from the Alouette-2, ISIS-1 and ISIS-2 satellites. One, TOPIST (TOPside Ionogram Scalar with True-height algorithm) from the University of Massachusetts Lowell, is designed for the automatic identification of the topside-ionogram ionospheric-reflection traces and their inversion into vertical electron-density profiles Ne(h). TOPIST also has the capability of manual intervention. The other application, from the Goddard Space Flight Center based on the FORTRAN code of John E. Jackson from the 1960s, is designed as an IDL-based interactive program for the scaling of selected digital topside-sounder ionograms. The Jackson code has also been modified, with some effort, so as to run on modern computers. This modification was motivated by the need to scale selected ionograms from the millions of Alouette/ISIS topside-sounder ionograms that only exist on 35-mm film. During this modification, it became evident that it would be more efficient to design a new code, based on the capabilities of present-day computers, than to continue to modify the old code. Such a new code has been produced and here we will describe its capabilities and compare Ne(h) profiles produced from it with those produced by the Jackson code. The concept of the new code is to assume an initial Ne(h) and derive a final Ne(h) through an iteration process that makes the resulting apparent-height profile fir the scaled values within a certain error range. The new code can be used on the X-, O-, and Z-mode traces. It does not assume any predefined profile shape between two contiguous points, like the exponential rule used in Jackson s program. Instead, Monotone Piecewise Cubic Interpolation is applied in the global profile to keep the monotone nature of the profile, which also ensures better smoothness

Development of Residual Gas Profile Monitors at GSI

International Nuclear Information System (INIS)

Giacomini, T.; Forck, P.; Barabin, S.; Liakin, D.; Skachkov, V.

2004-01-01

Beam profile measurements at modern ion synchrotrons and storage rings require high timing performances on a turn-by-turn basis. High spatial resolutions are essential for cold beams and beamwidth measurings. The currently used RGM supported very interesting measurements and applications. Due to the readout technology the spatial and time resolution is limited. To meet the expanded demands a more comprehensive device is under development. It will be an all-purpose residual gas monitor to cover the wide range of beam currents and transversal particle distributions. Due to the fast profile detection it will operate on primary electrons after residual gas ionization. A magnetic field of 100 mT binds them to the ionization point inside 0.1-mm orbits. The high-resolution mode will be read out by a digital CCD camera with an upstream MCP-phosphor screen assembly. It is planned to read out the fast turn-by-turn mode by an array of 100 photodiodes with a resolution of 1 mm. Every photodiode is equipped with an amplifier-digitizer device providing a frame rate of ∼ 10 MSamples/s

Development of Residual Gas Profile Monitors at GSI

Science.gov (United States)

Giacomini, T.; Barabin, S.; Forck, P.; Liakin, D.; Skachkov, V.

2004-11-01

Beam profile measurements at modern ion synchrotrons and storage rings require high timing performances on a turn-by-turn basis. High spatial resolutions are essential for cold beams and beamwidth measurings. The currently used RGM supported very interesting measurements and applications. Due to the readout technology the spatial and time resolution is limited. To meet the expanded demands a more comprehensive device is under development. It will be an all-purpose residual gas monitor to cover the wide range of beam currents and transversal particle distributions. Due to the fast profile detection it will operate on primary electrons after residual gas ionization. A magnetic field of 100 mT binds them to the ionization point inside 0.1-mm orbits. The high-resolution mode will be read out by a digital CCD camera with an upstream MCP-phosphor screen assembly. It is planned to read out the fast turn-by-turn mode by an array of 100 photodiodes with a resolution of 1 mm. Every photodiode is equipped with an amplifier-digitizer device providing a frame rate of ˜ 10 MSamples/s.

Pemberian Kredit Pada Koperasi Menggunakan Metode Profile Matching

Directory of Open Access Journals (Sweden)

Budi Sudradjat

2017-09-01

Abstract Cooperatives is an institution economic have function in the process of the increase in community welfare, Travel cooperatives not easy to reach position like now. The existence of movement cooperatives as an institution economic expected to act as propulsion engine national economic activity as well as soko teachers the country economy. Bhakti BPJS Kesehatan Service Cooperative is a cooperative engaged in services, forms of cooperative services to the community one is to lend funds (credit to help resolve the financial problems in the community. In granting the credit cooperatives need to do proper research and calculations to prospective customers who will take credit cooperatives, to avoid mistakes in decision making required data processing is fast, precise and accurate. With the Application Profile Matching Method For Determining Eligibility Lending In BPJS Kesehatan Service Cooperative Bhakti is the best solution to solve the problems that exist in this company, because with this method the decision taken by the cooperative members have been more thorough and detailed than the previous.   Keywords: Decision Support Systems, Profile Matching, The feasibility of the provision of credit.

Optimization of diclofenac sodium profile from halloysite nanotubules.

Science.gov (United States)

Krejčová, Kateřina; Deasy, Patrick B; Rabišková, Miloslava

2013-04-01

Halloysite, aluminosilicate clay with the particle shape of multilayered hollow nanotubes, used in various non-medical applications, e.g. in ceramic industry, was discovered for pharmaceutical purposes in recent years. Several drugs of hydrophilic and lipophilic nature have been successfully encapsulated into halloysite tubules in order to modify their dissolution profile. The main goal of this experiment was to optimize the dissolution profile of diclofenac sodium - a drug with problematic solubility - from halloysite tubules using various polymers. Loading of the drug together with povidone or Eudragit® RS did not lead to drug burst effect reduction and its slower dissolution. In the case of povidone, drug improved wettability and solubilization rather than viscosity increasing expectations were observed. Eudragit® RS formed a solid dispersion with diclofenac sodium and thus the solvent/drug solution penetration through the polymer and not the drug solubility was the dissolution rate limiting factor. Reduction of the burst effect and further prolongation of drug release was achieved by coating the drug-loaded halloysite with chitosan. This formulation exhibited a diffusion-controlled prolonged release following Higuchi kinetic model.

1H-13C NMR-based profiling of biotechnological starch utilization

DEFF Research Database (Denmark)

Sundekilde, Ulrik K.; Meier, Sebastian

2016-01-01

Starch is used in food-and non-food applications as a renewable and degradable source of carbon and energy. Insight into the chemical detail of starch degradation remains challenging as the starch constituents amylose and amylopectin are homopolymers. We show that considerable molecular detail...... of starch fragmentation can be obtained from multivariate analysis of spectral features in optimized 1H-13C NMR spectroscopy of starch fragments to identify relevant features that distinguish processes in starch utilization. As a case study, we compare the profiles of starch fragments in commercial beer...... samples. Spectroscopic profiles of homooligomeric starch fragments can be excellent indicators of process conditions. In addition, differences in the structure and composition of starch fragments have predictive value for down-stream process output such as ethanol production from starch. Thus, high...

Development in Diagnostics Application to Control Advanced Tokamak Plasma

International Nuclear Information System (INIS)

Koide, Y.

2008-01-01

For continuous operation expected in DEMO, all the plasma current must be non-inductively driven, with self-generated neoclassical bootstrap current being maximized. The control of such steady state high performance tokamak plasma (so-called 'Advanced Tokamak Plasma') is a challenge because of the strong coupling between the current density, the pressure profile and MHD stability. In considering diagnostic needs for the advanced tokamak research, diagnostics for MHD are the most fundamental, since discharges which violate the MHD stability criteria either disrupt or have significantly reduced confinement. This report deals with the development in diagnostic application to control advanced tokamak plasma, with emphasized on recent progress in active feedback control of the current profile and the pressure profile under DEMO-relevant high bootstrap-current fraction. In addition, issues in application of the present-day actuators and diagnostics for the advanced control to DEMO will be briefly addressed, where port space for the advanced control may be limited so as to keep sufficient tritium breeding ratio (TBR)

Country nuclear power profiles

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

The preparation of Country Nuclear Power Profiles was initiated within the framework of the IAEA`s programme for nuclear power plant performance assessment and feedback. It responded to a need for a database and a technical document containing a description of the energy and economic situation and the primary organizations involved in nuclear power in IAEA Member States. The task was included in the IAEA`s programmes for 1993/1994 and 1995/1996. In March 1993, the IAEA organized a Technical Committee meeting to discuss the establishment of country data ``profiles``, to define the information to be included in the profiles and to review the information already available in the IAEA. Two expert meetings were convened in November 1994 to provide guidance to the IAEA on the establishment of the country nuclear profiles, on the structure and content of the profiles, and on the preparation of the publication and the electronic database. In June 1995, an Advisory Group meeting provided the IAEA with comprehensive guidance on the establishment and dissemination of an information package on industrial and organizational aspects of nuclear power to be included in the profiles. The group of experts recommended that the profiles focus on the overall economic, energy and electricity situation in the country and on its nuclear power industrial structure and organizational framework. In its first release, the compilation would cover all countries with operating power plants by the end of 1995. It was also recommended to further promote information exchange on the lessons learned from the countries engaged in nuclear programmes. For the preparation of this publication, the IAEA received contributions from the 29 countries operating nuclear power plants and Italy. A database has been implemented and the profiles are supporting programmatic needs within the IAEA; it is expected that the database will be publicly accessible in the future. Refs, figs, tabs.

Country nuclear power profiles

International Nuclear Information System (INIS)

1998-03-01

The preparation of Country Nuclear Power Profiles was initiated within the framework of the IAEA's programme for nuclear power plant performance assessment and feedback. It responded to a need for a database and a technical document containing a description of the energy and economic situation and the primary organizations involved in nuclear power in IAEA Member States. The task was included in the IAEA's programmes for 1993/1994 and 1995/1996. In March 1993, the IAEA organized a Technical Committee meeting to discuss the establishment of country data ''profiles'', to define the information to be included in the profiles and to review the information already available in the IAEA. Two expert meetings were convened in November 1994 to provide guidance to the IAEA on the establishment of the country nuclear profiles, on the structure and content of the profiles, and on the preparation of the publication and the electronic database. In June 1995, an Advisory Group meeting provided the IAEA with comprehensive guidance on the establishment and dissemination of an information package on industrial and organizational aspects of nuclear power to be included in the profiles. The group of experts recommended that the profiles focus on the overall economic, energy and electricity situation in the country and on its nuclear power industrial structure and organizational framework. In its first release, the compilation would cover all countries with operating power plants by the end of 1995. It was also recommended to further promote information exchange on the lessons learned from the countries engaged in nuclear programmes. For the preparation of this publication, the IAEA received contributions from the 29 countries operating nuclear power plants and Italy. A database has been implemented and the profiles are supporting programmatic needs within the IAEA; it is expected that the database will be publicly accessible in the future

Optical bi-sensorial measurement system for production control of extruded profiles

Science.gov (United States)

Weckenmann, A.; Bernstein, J.

2008-09-01

Extruded profiles are semi-finished products (made out of steel, brass, aluminum, synthetics...) which are appointed for wide applications in manufacturing of technical products. As yet used optical sensors in process control working to the shading technology detect the object's shadow orthographically to the axis of illumination. As a consequence they record it unattached by the profiles coat in measurement range at any point of the measured profile with high precision. As a matter of fact, concave zones cannot be captured. Alternatively the measurement of concave zones can be arranged by light-section systems. These do not comply with the required accuracy, are comparatively slow and moreover affected by dislocations of the section of the profile. A measurement system including a light-section and a shading system combines the advantages of both optical systems. It is to serve with a reliable conception for the assembly of a bi-sensorial measurement system consisting of both systems as well as suitable methods of analysis for the in-line inspection of concave profiles. As a result it contains conclusions concerning requirements of the light source, the arrangement of this source and the cameras, obtainable precision and sampling rate as well as the essential synchronization of both systems. After designing an appropriate prototype, the selected light-section system and the shading system will be synchronized and aligned. Therefore, the metered geometrical data will be merged for the evaluation of form deviation. So, developed and adapted software supports and contains proposals to the uncertainty after successful tests. The system and a calibration method will be proved in production where robustness will be a most critical despite of heat, dust and vibrations. The target uncertainty of less than 0.1 mm at every section of the profiles coat has to be met.

SAMP: Application Messaging for Desktop and Web Applications

Science.gov (United States)

Taylor, M. B.; Boch, T.; Fay, J.; Fitzpatrick, M.; Paioro, L.

2012-09-01

SAMP, the Simple Application Messaging Protocol, is a technology which allows tools to communicate. It is deployed in a number of desktop astronomy applications including ds9, Aladin, TOPCAT, World Wide Telescope and numerous others, and makes it straightforward for a user to treat a selection of these tools as a loosely-integrated suite, combining the most powerful features of each. It has been widely used within Virtual Observatory contexts, but is equally suitable for non-VO use. Enabling SAMP communication from web-based content has long been desirable. An obvious use case is arranging for a click on a web page link to deliver an image, table or spectrum to a desktop viewer, but more sophisticated two-way interaction with rich internet applications would also be possible. Use from the web however presents some problems related to browser sandboxing. We explain how the SAMP Web Profile, introduced in version 1.3 of the SAMP protocol, addresses these issues, and discuss the resulting security implications.

The state and profile of open source software projects in health and medical informatics.

Science.gov (United States)

Janamanchi, Balaji; Katsamakas, Evangelos; Raghupathi, Wullianallur; Gao, Wei

2009-07-01

Little has been published about the application profiles and development patterns of open source software (OSS) in health and medical informatics. This study explores these issues with an analysis of health and medical informatics related OSS projects on SourceForge, a large repository of open source projects. A search was conducted on the SourceForge website during the period from May 1 to 15, 2007, to identify health and medical informatics OSS projects. This search resulted in a sample of 174 projects. A Java-based parser was written to extract data for several of the key variables of each project. Several visually descriptive statistics were generated to analyze the profiles of the OSS projects. Many of the projects have sponsors, implying a growing interest in OSS among organizations. Sponsorship, we discovered, has a significant impact on project success metrics. Nearly two-thirds of the projects have a restrictive license type. Restrictive licensing may indicate tighter control over the development process. Our sample includes a wide range of projects that are at various stages of development (status). Projects targeted towards the advanced end user are primarily focused on bio-informatics, data formats, database and medical science applications. We conclude that there exists an active and thriving OSS development community that is focusing on health and medical informatics. A wide range of OSS applications are in development, from bio-informatics to hospital information systems. A profile of OSS in health and medical informatics emerges that is distinct and unique to the health care field. Future research can focus on OSS acceptance and diffusion and impact on cost, efficiency and quality of health care.

Determinación de perfiles para rotores de compresores de tornillo con perfil simétrico. // Profiles determination for screw compressors rotors with symmetrical profile.

Directory of Open Access Journals (Sweden)

A. Rivera Torres

2005-05-01

Full Text Available Los compresores rotativos de tornillo, constituyeron el acontecimiento histórico más relevante del siglo XX en el campodel proceso de compresión. Dentro de los elementos fundamentales de los compresores rotativos de tornillo se encuentranlos rotores, los cuales tienen lóbulos o canales helicoidales con perfiles con formas simétricas o asimétricas.En este articulo se presenta un método para el diseño de los perfiles de rotores para compresores o bombas de tornillo, conperfil circular, a partir del empleo de una curva de cuarto orden y la condición de conjugación de los engranajes, sin incluirel empleo de cicloides en la generación de dichos perfiles, lográndose características similares a la de los perfiles SRM.Palabras claves: Rotores, rotor macho, rotor hembra._____________________________________________________________________________Abstract:Rotary screw compressors constitute the most relevant historic event of the twentieth century in the field of the process ofcompression. The most fundamental elements of rotary screw compressors are the rotors, which have helical lobes or canalsand symmetrical or asymmetrical profiles.This paper presents a method of circular profile design for screw compressors or pumps, based on fourth order curves andthe conjugation of gears, which does not include the application of cycloids in profile generation but have similarcharacteristics to SRM profiles.Key words: rotors, male rotor, female rotor.

Significant effect of topographic normalization of airborne LiDAR data on the retrieval of plant area index profile in mountainous forests

Science.gov (United States)

Liu, Jing; Skidmore, Andrew K.; Heurich, Marco; Wang, Tiejun

2017-10-01

As an important metric for describing vertical forest structure, the plant area index (PAI) profile is used for many applications including biomass estimation and wildlife habitat assessment. PAI profiles can be estimated with the vertically resolved gap fraction from airborne LiDAR data. Most research utilizes a height normalization algorithm to retrieve local or relative height by assuming the terrain to be flat. However, for many forests this assumption is not valid. In this research, the effect of topographic normalization of airborne LiDAR data on the retrieval of PAI profile was studied in a mountainous forest area in Germany. Results show that, although individual tree height may be retained after topographic normalization, the spatial arrangement of trees is changed. Specifically, topographic normalization vertically condenses and distorts the PAI profile, which consequently alters the distribution pattern of plant area density in space. This effect becomes more evident as the slope increases. Furthermore, topographic normalization may also undermine the complexity (i.e., canopy layer number and entropy) of the PAI profile. The decrease in PAI profile complexity is not solely determined by local topography, but is determined by the interaction between local topography and the spatial distribution of each tree. This research demonstrates that when calculating the PAI profile from airborne LiDAR data, local topography needs to be taken into account. We therefore suggest that for ecological applications, such as vertical forest structure analysis and modeling of biodiversity, topographic normalization should not be applied in non-flat areas when using LiDAR data.

A novel method for decomposing electricity feeder load into elementary profiles from customer information

International Nuclear Information System (INIS)

Gerossier, Alexis; Barbier, Thibaut; Girard, Robin

2017-01-01

Highlights: •Use of aggregated electricity load profiles and customer description at feeder level. •Statistical recovery of elementary load profiles with customer categorization. •Generation of load demand profiles for unknown feeders and new local areas. •Relevancy of the different categorizations. -- Abstract: To plan a distribution grid involves making a long-term forecast of sub-hourly demand, which requires modeling the demand and its dynamics with aggregated measurement data. Distribution system operators (DSOs) have been recording electricity sub-hourly demand delivered by their medium-voltage feeders (around 1000—10,000 customers) for several years. Demand profiles differ widely among the various considered feeders. This is partly due to the varying mix of customer categories from one feeder to another. To overcome this issue, elementary demand profiles are often associated with customer categories and then combined according to a mix description. This paper presents a novel method to estimate elementary profiles that only requires several feeder demand curves and a description of customers. The method relies on a statistical blind source model and a new estimation procedure based on the augmented Lagrangian method. The use of feeders to estimate elementary profiles means that measurements are fully representative and continuously updated. We illustrate the proposed method through a case study comprising around 1000 feeder demand curves operated by the main French DSO Enedis. We propose an application o that uses the obtained profiles to evaluate the contribution of any set of new customers to a feeder peak load. We show that profiles enable a simulation of new unmeasured areas with errors of around 20%. We also show how our method can be used to evaluate the relevancy of different customer categorizations.

TDR water content inverse profiling in layered soils during infiltration and evaporation

Science.gov (United States)

Greco, R.; Guida, A.

2009-04-01

During the last three decades, time domain reflectometry (TDR) has become one of the most commonly used tools for soil water content measurements either in laboratory or in the field. Indeed, TDR provides easy and cheap water content estimations with relatively small disturbance to the investigated soil. TDR measurements of soil water content are based on the strong correlation between relative dielectric permittivity of wet soil and its volumetric water content. Several expressions of the relationship between relative dielectric permittivity and volumetric water content have been proposed, empirically stated (Topp et al., 1980) as well as based on semi-analytical approach to dielectric mixing models (Roth et al., 1990; Whalley, 1993). So far, TDR field applications suffered the limitation due to the capability of the technique of estimating only the mean water content in the volume investigated by the probe. Whereas the knowledge of non homogeneous vertical water content profiles was needed, it was necessary to install either several vertical probes of different length or several horizontal probes placed in the soil at different depths, in both cases strongly increasing soil disturbance as well as the complexity of the measurements. Several studies have been recently dedicated to the development of inversion methods aimed to extract more information from TDR waveforms, in order to estimate non homogeneous moisture profiles along the axis of the metallic probe used for TDR measurements. A common feature of all these methods is that electromagnetic transient through the wet soil along the probe is mathematically modelled, assuming that the unknown soil water content distribution corresponds to the best agreement between simulated and measured waveforms. In some cases the soil is modelled as a series of small layers with different dielectric properties, and the waveform is obtained as the result of the superposition of multiple reflections arising from impedance

Testing the capacity of a Multi-Nutrient profiling system to guide food and beverage reformulation

NARCIS (Netherlands)

Combet, Emilie; Vlassopoulos, Antonis; Molenberg, Famke; Gressier, Mathilde; Privet, Lisa; Wratten, Craig; Sharif, Sahar; Vieux, Florent; Lehmann, Undine; Masset, Gabriel

2017-01-01

Nutrient profiling ranks foods based on their nutrient composition, with applications in multiple aspects of food policy. We tested the capacity of a category-specific model developed for product reformulation to improve the average nutrient content of foods, using five national food composition

The Uses and Future Prospects of Metabolomics and Targeted Metabolite Profiling in Cell Factory Development

DEFF Research Database (Denmark)

Harrison, Scott James; Herrgard, Markus

2013-01-01

, these broader measurements of the cellular metabolic state are now becoming part of the toolbox used to characterize cell factories. In this review we briefly summarize the benefits and challenges of global metabolomics and targeted metabolite profiling methods and discuss the application of these methods...

Application of microwave radiometer and wind profiler data in the estimation of wind gust associated with intense convective weather

International Nuclear Information System (INIS)

Chan, P W; Wong, K H

2008-01-01

Estimates of the wind gusts associated with intense convective weather could be obtained using empirical relationships such as GUSTEX based on radiosonde measurements. However, such data are only available a couple of times a day and may not reflect the rapidly changing atmospheric condition in spring and summer times. The feasibility of combining the thermodynamic profiles from a ground-based microwave radiometer and wind profiles given by radar wind profilers in the continuous estimation of wind gusts is studied in this paper. Based on the results of a 4-month trial of a microwave radiometer in Hong Kong in 2004, the estimated and the actual gusts are reasonably well correlated. It is also found that the wind gusts so estimated provide better indications of the strength of squalls compared with those based on radiosonde measurements and with a lead time of about one hour

Professional assessment of facial profile attractiveness.

Science.gov (United States)

Soh, Jen; Chew, Ming Tak; Wong, Hwee Bee

2005-08-01

The aim of this study was to compare the assessments of Chinese facial profile attractiveness by orthodontists and oral surgeons. The sample comprised 31 dental professionals (20 orthodontists, 11 oral surgeons) in an Asian community. Facial profile photographs and lateral cephalometric radiographs of 2 Chinese adults (1 man, 1 woman) with normal profiles, Class I incisor relationships, and Class I skeletal patterns were digitized. The digital images were modified by altering cephalometric skeletal and dental hard tissue Chinese normative values in increments of 2 standard deviations in the anteroposterior plane to obtain 7 facial profiles for each sex. The images were bimaxillary protrusion, protrusive mandible, retrusive mandible, normal profile (Class I incisor with Class I skeletal pattern), retrusive maxilla, protrusive maxilla, and bimaxillary retrusion. The Mann-Whitney U test was used to determine professional differences in assessment. Multiple regression analysis was performed with age, professional status, sex, and number of years in practice as independent variables. A strong correlation was found in the profile assessment between orthodontists and oral surgeons. Normal and bimaxillary retrusive Chinese male and female profiles were judged to be highly attractive by orthodontists and oral surgeons. Chinese male and female profiles with protrusive mandibles were judged the least attractive. There was a difference in professional opinion about the most attractive male profile (P profile and oral surgeons preferring a fuller normal Chinese profile. Sex of dental professionals and number of years in clinical practice were found to affect profile rankings.

Diode-laser-based water vapor differential absorption lidar (DIAL) profiler evaluation

Science.gov (United States)

Spuler, S.; Weckwerth, T.; Repasky, K. S.; Nehrir, A. R.; Carbone, R.

2012-12-01

We are in the process of evaluating the performance of an eye-safe, low-cost, diode-laser-based, water vapor differential absorption lidar (DIAL) profiler. This class of instrument may be capable of providing continuous water vapor and aerosol backscatter profiles at high vertical resolution in the atmospheric boundary layer (ABL) for periods of months to years. The technology potentially fills a national long term observing facility gap and could greatly benefit micro- and meso-meteorology, water cycle, carbon cycle and, more generally, biosphere-hydrosphere-atmosphere interaction research at both weather and climate variability time scales. For the evaluation, the Montana State University 3rd generation water vapor DIAL was modified to enable unattended operation for a period of several weeks. The performance of this V3.5 version DIAL was tested at MSU and NCAR in June and July of 2012. Further tests are currently in progress with Howard University at Beltsville, Maryland; and with the National Weather Service and Oklahoma University at Dallas/Fort Worth, Texas. The presentation will include a comparison of DIAL profiles against meteorological "truth" at the aforementioned locations including: radiosondes, Raman lidars, microwave and IR radiometers, AERONET and SUOMINET systems. Instrument reliability, uncertainty, systematic biases, detection height statistics, and environmental complications will be evaluated. Performance will be judged in the context of diverse scientific applications that range from operational weather prediction and seasonal climate variability, to more demanding climate system process studies at the land-canopy-ABL interface. Estimating the extent to which such research and operational applications can be satisfied with a low cost autonomous network of similar instruments is our principal objective.

In situ profiling of eastern Arabian Sea coastal waters using a new autonomous vertical profiler

Digital Repository Service at National Institute of Oceanography (India)

Desa, E.S.; Madhan, R.; Dabholkar, N.A.; Prabhudesai, S.P.; Navelkar, G.S.; Mascarenhas, A.A.M.Q.; Afzulpurkar, S.; Phaldesai, M.; Maurya, P.

The autonomous vertical profiler (AVP) presented here offers a fast, cost-effective, optimized approach to profiling in coastal waters. It consists of a hands-free, slightly buoyant, motor-driven in situ robot profiler that requires no operator...

Role of noise in the diode-laser spectroscopy of the spectral line profile

International Nuclear Information System (INIS)

Nadezhdinskii, Aleksandr I; Plotnichenko, V V; Ponurovskii, Ya Ya; Spiridonov, Maksim V

2000-01-01

Questions concerning precise measurements of the spectral-line-profile parameters by diode-laser spectroscopic methods were examined. The instrumental function of a distributed-feedback diode laser (λ =1.53 μm), consisting of the additive contributions of the noise due to spontaneous emission, frequency fluctuations, and intensity fluctuations, was investigated. An analytical formula was obtained for the spectrum of the diode-laser field formed by frequency fluctuations. The spectral density g 0 of the frequency fluctuations, determining the width of the central part of the emission line profile of a diode laser, was found by two independent methods (by fitting to a Doppler-broadened absorption line profile and by finding the intensity of the residual radiation and the saturated-absorption line width). The parameters Ω and Γ of the spectral density of the frequency fluctuations, coupled to the relaxation oscillations and determining the wing of the diode-laser emission line profile, were determined experimentally. By taking into account the instrumental function of the diode laser, involving successive convolution with the recorded emission spectra, it was possible to reproduce correctly the spectral line profile and to solve accurately the problem of the 'optical zero'. The role of the correlation between the intensity noise and the diode-laser frequency was considered. (laser applications and other topics in quantum electronics)

Assessing the Accuracy of Quantitative Molecular Microbial Profiling

Directory of Open Access Journals (Sweden)

Denise M. O'Sullivan

2014-11-01

Full Text Available The application of high-throughput sequencing in profiling microbial communities is providing an unprecedented ability to investigate microbiomes. Such studies typically apply one of two methods: amplicon sequencing using PCR to target a conserved orthologous sequence (typically the 16S ribosomal RNA gene or whole (metagenome sequencing (WGS. Both methods have been used to catalog the microbial taxa present in a sample and quantify their respective abundances. However, a comparison of the inherent precision or bias of the different sequencing approaches has not been performed. We previously developed a metagenomic control material (MCM to investigate error when performing different sequencing strategies. Amplicon sequencing using four different primer strategies and two 16S rRNA regions was examined (Roche 454 Junior and compared to WGS (Illumina HiSeq. All sequencing methods generally performed comparably and in good agreement with organism specific digital PCR (dPCR; WGS notably demonstrated very high precision. Where discrepancies between relative abundances occurred they tended to differ by less than twofold. Our findings suggest that when alternative sequencing approaches are used for microbial molecular profiling they can perform with good reproducibility, but care should be taken when comparing small differences between distinct methods. This work provides a foundation for future work comparing relative differences between samples and the impact of extraction methods. We also highlight the value of control materials when conducting microbial profiling studies to benchmark methods and set appropriate thresholds.

Approximate Stokes Drift Profiles in Deep Water

Science.gov (United States)

Breivik, Øyvind; Janssen, Peter A. E. M.; Bidlot, Jean-Raymond

2014-09-01

A deep-water approximation to the Stokes drift velocity profile is explored as an alternative to the monochromatic profile. The alternative profile investigated relies on the same two quantities required for the monochromatic profile, viz the Stokes transport and the surface Stokes drift velocity. Comparisons with parametric spectra and profiles under wave spectra from the ERA-Interim reanalysis and buoy observations reveal much better agreement than the monochromatic profile even for complex sea states. That the profile gives a closer match and a more correct shear has implications for ocean circulation models since the Coriolis-Stokes force depends on the magnitude and direction of the Stokes drift profile and Langmuir turbulence parameterizations depend sensitively on the shear of the profile. The alternative profile comes at no added numerical cost compared to the monochromatic profile.

Parent Prevention Communication Profiles and Adolescent Substance Use: A Latent Profile Analysis and Growth Curve Model

Science.gov (United States)

Choi, Hye Jeong; Miller-Day, Michelle; Shin, YoungJu; Hecht, Michael L.; Pettigrew, Jonathan; Krieger, Janice L.; Lee, JeongKyu; Graham, John W.

2017-01-01

This current study identifies distinct parent prevention communication profiles and examines whether youth with different parental communication profiles have varying substance use trajectories over time. Eleven schools in two rural school districts in the Midwestern United States were selected, and 784 students were surveyed at three time points from the beginning of 7th grade to the end of 8th grade. A series of latent profile analyses were performed to identify discrete profiles/subgroups of substance-specific prevention communication (SSPC). The results revealed a 4-profile model of SSPC: Active-Open, Passive-Open, Active-Silent, and Passive-Silent. A growth curve model revealed different rates of lifetime substance use depending on the youth’s SSPC profile. These findings have implications for parenting interventions and tailoring messages for parents to fit specific SSPC profiles. PMID:29056872

Consumer involvement profiles: An application of consumer involvement in mobile industry

Directory of Open Access Journals (Sweden)

Homa Rahbarian

2014-04-01

Full Text Available This paper investigates consumer involvement profile among people who intend to purchase mobile devises. The study considers the effects of various factors influencing on purchase intention including consumers’ personal characteristics such as age, gender, income as well as some external factors including advertisement. The study uses a questionnaire in Likert scale, originally developed by O’Cass (2000 [O’Cass, A. (2000. An assessment of consumers' product, purchase decision, advertising and consumption involvement in fashion clothing. Journal of Economic Psychology, 21, 545-576.]. The questionnaire has been distributed among 385 people, randomly who purchased mobile devices from a mall in city of Tehran, Iran. Using Pearson correlation test, the study has concluded that oral advertisement as well as consumer purchase involvement have positive and strong relationship with consumer’s purchase intention. In terms of age, people aged 20-30 maintained the highest purchase intention. In addition, in terms of gender, men had more purchase involvement than women did.

Exploring the Constraint Profile of Winter Sports Resort Tourist Segments.

Science.gov (United States)

Priporas, Constantinos-Vasilios; Vassiliadis, Chris A; Bellou, Victoria; Andronikidis, Andreas

2015-09-01

Many studies have confirmed the importance of market segmentation both theoretically and empirically. Surprisingly though, no study has so far addressed the issue from the perspective of leisure constraints. Since different consumers face different barriers, we look at participation in leisure activities as an outcome of the negotiation process that winter sports resort tourists go through, to balance between related motives and constraints. This empirical study reports the findings on the applicability of constraining factors in segmenting the tourists who visit winter sports resorts. Utilizing data from 1,391 tourists of winter sports resorts in Greece, five segments were formed based on their constraint, demographic, and behavioral profile. Our findings indicate that such segmentation sheds light on factors that could potentially limit the full utilization of the market. To maximize utilization, we suggest customizing marketing to the profile of each distinct winter sports resort tourist segment that emerged.

Exploring the Constraint Profile of Winter Sports Resort Tourist Segments

Science.gov (United States)

Priporas, Constantinos-Vasilios; Vassiliadis, Chris A.; Bellou, Victoria; Andronikidis, Andreas

2014-01-01

Many studies have confirmed the importance of market segmentation both theoretically and empirically. Surprisingly though, no study has so far addressed the issue from the perspective of leisure constraints. Since different consumers face different barriers, we look at participation in leisure activities as an outcome of the negotiation process that winter sports resort tourists go through, to balance between related motives and constraints. This empirical study reports the findings on the applicability of constraining factors in segmenting the tourists who visit winter sports resorts. Utilizing data from 1,391 tourists of winter sports resorts in Greece, five segments were formed based on their constraint, demographic, and behavioral profile. Our findings indicate that such segmentation sheds light on factors that could potentially limit the full utilization of the market. To maximize utilization, we suggest customizing marketing to the profile of each distinct winter sports resort tourist segment that emerged. PMID:29708114

Purification, characterization and application of laccase from ...

African Journals Online (AJOL)

Administrator

2007-05-16

. E-mail: duran@iqm.unicamp.br. .... The elution profile was monitored at 280 nm. Amino acid analysis was performed ..... Enzyme applications in the textile industry. Rev Progr Coloration Rel Topics 30:41-44. Duran N, Rosa ...

A self-adapting and altitude-dependent regularization method for atmospheric profile retrievals

Directory of Open Access Journals (Sweden)

M. Ridolfi

2009-03-01

Full Text Available MIPAS is a Fourier transform spectrometer, operating onboard of the ENVISAT satellite since July 2002. The online retrieval algorithm produces geolocated profiles of temperature and of volume mixing ratios of six key atmospheric constituents: H₂O, O₃, HNO₃, CH₄, N₂O and NO₂. In the validation phase, oscillations beyond the error bars were observed in several profiles, particularly in CH₄ and N₂O.

To tackle this problem, a Tikhonov regularization scheme has been implemented in the retrieval algorithm. The applied regularization is however rather weak in order to preserve the vertical resolution of the profiles.

In this paper we present a self-adapting and altitude-dependent regularization approach that detects whether the analyzed observations contain information about small-scale profile features, and determines the strength of the regularization accordingly. The objective of the method is to smooth out artificial oscillations as much as possible, while preserving the fine detail features of the profile when related information is detected in the observations.

The proposed method is checked for self consistency, its performance is tested on MIPAS observations and compared with that of some other regularization schemes available in the literature. In all the considered cases the proposed scheme achieves a good performance, thanks to its altitude dependence and to the constraints employed, which are specific of the inversion problem under consideration. The proposed method is generally applicable to iterative Gauss-Newton algorithms for the retrieval of vertical distribution profiles from atmospheric remote sounding measurements.

Depth-profiling by confocal Raman microscopy (CRM): data correction by numerical techniques.

Science.gov (United States)

Tomba, J Pablo; Eliçabe, Guillermo E; Miguel, María de la Paz; Perez, Claudio J

2011-03-01

The data obtained in confocal Raman microscopy (CRM) depth profiling experiments with dry optics are subjected to significant distortions, including an artificial compression of the depth scale, due to the combined influence of diffraction, refraction, and instrumental effects that operate on the measurement. This work explores the use of (1) regularized deconvolution and (2) the application of simple rescaling of the depth scale as methodologies to obtain an improved, more precise, confocal response. The deconvolution scheme is based on a simple predictive model for depth resolution and the use of regularization techniques to minimize the dramatic oscillations in the recovered response typical of problem inversion. That scheme is first evaluated using computer simulations on situations that reproduce smooth and sharp sample transitions between two materials and finally it is applied to correct genuine experimental data, obtained in this case from a sharp transition (planar interface) between two polymeric materials. It is shown that the methodology recovers very well most of the lost profile features in all the analyzed situations. The use of simple rescaling appears to be only useful for correcting smooth transitions, particularly those extended over distances larger than those spanned by the operative depth resolution, which limits the strategy to the study of profiles near the sample surface. However, through computer simulations, it is shown that the use of water immersion objectives may help to reduce optical distortions and to expand the application window of this simple methodology, which could be useful, for instance, to safely monitor Fickean sorption/desorption of penetrants in polymer films/coatings in a nearly noninvasive way.

Ti(r) profiles from the JET neutron profile monitor for ohmic discharges

Energy Technology Data Exchange (ETDEWEB)

Esposito, B. (ENEA, Frascati (Italy). Centro Ricerche Energia); Marcus, F.B.; Conroy, S.; Jarvis, O.N.; Loughlin, M.J.; Sadler, G.; Belle, P. van (Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking); Adams, J.M.; Watkins, N. (AEA Industrial Technology, Harwell (United Kingdom))

1991-01-01

A study has been made of the neutron emissivity, using the JET neutron profile monitor, obtained for ohmically heated deuterium discharges. Both one-dimensional (1-D) best-fit inversion procedures and 2-D tomography have been used to deduce the radial profile of the neutron emission from the line-integral data. The profiles of ion temperature and ion thermal conductivity are then derived. The scaling of the ion thermal conductivity with plasma current is found to be opposite to that of neoclassical theory. (author) 4 refs., 5 figs.

Assimilation of Atmospheric InfraRed Sounder (AIRS) Profiles using WRF-Var

Science.gov (United States)

Zavodsky, Brad; Jedlovec, Gary J.; Lapenta, William

2008-01-01

The Weather Research and Forecasting (WRF) model contains a three-dimensional variational (3DVAR) assimilation system (WRF-Var), which allows a user to join data from multiple sources into one coherent analysis. WRF-Var combines observations with a background field traditionally generated using a previous model forecast through minimization of a cost function. In data sparse regions, remotely-sensed observations may be able to improve analyses and produce improved forecasts. One such source comes from the Atmospheric Infrared Sounder (AIRS), which together with the Advanced Microwave Sounding Unit (AMSU), represents one of the most advanced space-based atmospheric sounding systems. The combined AIRS/AMSU system provides radiance measurements used as input to a sophisticated retrieval scheme which has been shown to produce temperature profiles with an accuracy of 1 K over 1 km layers and humidity profiles with accuracy of 15% in 2 km layers in both clear and partly cloudy conditions. The retrieval algorithm also provides estimates of the accuracy of the retrieved values at each pressure level, allowing the user to select profiles based on the required error tolerances of the application. The purpose of this paper is to describe a procedure to optimally assimilate high-resolution AIRS profile data into a regional configuration of the Advanced Research WRF (ARW) version 2.2 using WRF-Var. The paper focuses on development of background error covariances for the regional domain and background field type using gen_be and an optimal methodology for ingesting AIRS temperature and moisture profiles as separate overland and overwater retrievals with different error characteristics in the WRF-Var. The AIRS thermodynamic profiles are obtained from the version 5.0 Earth Observing System (EOS) science team retrieval algorithm and contain information about the quality of each temperature layer. The quality indicators are used to select the highest quality temperature and moisture

A new electrophoretic focusing principle: focusing of nonamphoteric weak ionogenic analytes using inverse electromigration dispersion profiles.

Science.gov (United States)

Gebauer, Petr; Malá, Zdena; Bocek, Petr

2010-03-01

This contribution introduces a new separation principle in CE which offers focusing of weak nonamphoteric ionogenic species and their inherent transport to the detector. The prerequisite condition for application of this principle is the existence of an inverse electromigration dispersion profile, i.e. a profile where pH is decreasing toward the anode or cathode for focusing of anionic or cationic weak analytes, respectively. The theory presented defines the principal conditions under which an analyte is focused on a profile of this type. Since electromigration dispersion profiles are migrating ones, the new principle offers inherent transport of focused analytes into the detection cell. The focusing principle described utilizes a mechanism different from both CZE (where separation is based on the difference in mobilities) and IEF (where separation is based on difference in pI), and hence, offers another separation dimension in CE. The new principle and its theory presented here are supplemented by convincing experiments as their proof.

On depth profiling of hydrogen and helium isotopes and its application to ion-implantation studies

International Nuclear Information System (INIS)

Boettiger, J.

1979-01-01

The thesis is divided into two parts, the first being a general review of the experimental methods for depth profiling of light isotopes, where ion beams are used. In the second part, studies of ion implantation of hydrogen and helium isotopes, applying the techniques discussed in the first part, are described. The paper summarizes recent experimental results and discusses recent developments. (Auth.)

Synthesis of national risk profile

Science.gov (United States)

1979-01-01

The methodology used and results obtained in computing the national risk profile for carbon fibers (CF) released after an aircraft accident (fire or explosion) are presented. The computation was performed by use of twenty-six individual conditional risk profiles, together with the extrapolation of these profiles to other U.S. airports. The risk profile was obtained using 1993 CF utilization forecasts, but numbers of facilities were taken from 1972 and 1975 census data, while losses were expressed in 1977 dollars.

THE BEHAVIORAL PROFILE OF HARVESTER OPERATORS

Directory of Open Access Journals (Sweden)

Millana Burger Pagnussat

Full Text Available ABSTRACT This study aims to characterize the behavioral profile of harvester operators, with the goal of assisting forest managers in selecting and training new teams of employees. A forest company located in central-western Brazil was examined from a sample of 20 harvester operators that did not have experience carrying out the functions of their industry. A behavioral profile evaluation tool was used, consisting of a management system that creates a profile based on behavioral competencies; it was initially used to develop a profile of a high-performing harvester operator; or rather, a reference profile. Next, the behavioral profile of the operators were grouped into distinct classes and compared with the reference profile to identify traits that could positively or negatively affect an operators' performance. An optimal profile had the following qualities: attentive to details, meets deadlines and follows rules, technically-oriented, patient with repetitive tasks, the ability to avoid conflicts, and being an introvert. An improper profile included aspects such as aggressiveness, being argumentative, being persuasive, explosive, and tense at work. The behavioral profile evaluation tool can support the process of choosing forest machine operators; however, it is important to also consider skills and work experience.

Subsurface Profile Mapping using 3-D Compressive Wave Imaging

Directory of Open Access Journals (Sweden)

Hazreek Z A M

2017-01-01

Full Text Available Geotechnical site investigation related to subsurface profile mapping was commonly performed to provide valuable data for design and construction stage based on conventional drilling techniques. From past experience, drilling techniques particularly using borehole method suffer from limitations related to expensive, time consuming and limited data coverage. Hence, this study performs subsurface profile mapping using 3-D compressive wave imaging in order to minimize those conventional method constraints. Field measurement and data analysis of compressive wave (p-wave, vp was performed using seismic refraction survey (ABEM Terraloc MK 8, 7 kg of sledgehammer and 24 units of vertical geophone and OPTIM (SeisOpt@Picker & SeisOpt@2D software respectively. Then, 3-D compressive wave distribution of subsurface studied was obtained using analysis of SURFER software. Based on 3-D compressive wave image analyzed, it was found that subsurface profile studied consist of three main layers representing top soil (vp = 376 – 600 m/s, weathered material (vp = 900 – 2600 m/s and bedrock (vp > 3000 m/s. Thickness of each layer was varied from 0 – 2 m (first layer, 2 – 20 m (second layer and 20 m and over (third layer. Moreover, groundwater (vp = 1400 – 1600 m/s starts to be detected at 2.0 m depth from ground surface. This study has demonstrated that geotechnical site investigation data related to subsurface profiling was applicable to be obtained using 3-D compressive wave imaging. Furthermore, 3-D compressive wave imaging was performed based on non destructive principle in ground exploration thus consider economic, less time, large data coverage and sustainable to our environment.

An energy-efficient metro speed profiles for energy savings: application to the Valencia metro

Energy Technology Data Exchange (ETDEWEB)

Villalba Sanchis, I.; Salvador Zuriaga, P.

2016-07-01

Nowadays one of the main priorities for metro line operators is the reduction of energy consumption, due to the environmental impact and economic cost. In order to achieve this objective different strategies can be applied, normally focused into rolling stock, infrastructure and/or operation. Considering short-term measures and related to the traffic operation strategies, different approaches are being researched. One of the most effective strategy which reduce net energy consumption is the use of efficient driving techniques. These techniques produces a speed profile between two stations that requires the minimum net energy consumption, without degrading commercial running times or passenger comfort. In this paper, a computer model for calculating the metro vehicles speed profiles minimizing the energy consumption was developed. The equations considered in the model represent the behavior of a single vehicle operated under manual driving, subject to different constraints such as the headway, cycle time, distances and acceleration limits. The proposed model calculates different commands to be systematically executed by the driver. The resulting simulator has been tuned by means of on board measurements of speed, accelerations and energy consumption obtained along different lines in Metro de Valencia network. For this purpose, different scenarios are analyzed to assess the achievable energy savings. In general terms and comparing with the actual energy consumption, the solutions proposed can reduce the net energy consumption around 19%. (Author)

Accelerated Profile HMM Searches.

Directory of Open Access Journals (Sweden)

Sean R Eddy

2011-10-01

Full Text Available Profile hidden Markov models (profile HMMs and probabilistic inference methods have made important contributions to the theory of sequence database homology search. However, practical use of profile HMM methods has been hindered by the computational expense of existing software implementations. Here I describe an acceleration heuristic for profile HMMs, the "multiple segment Viterbi" (MSV algorithm. The MSV algorithm computes an optimal sum of multiple ungapped local alignment segments using a striped vector-parallel approach previously described for fast Smith/Waterman alignment. MSV scores follow the same statistical distribution as gapped optimal local alignment scores, allowing rapid evaluation of significance of an MSV score and thus facilitating its use as a heuristic filter. I also describe a 20-fold acceleration of the standard profile HMM Forward/Backward algorithms using a method I call "sparse rescaling". These methods are assembled in a pipeline in which high-scoring MSV hits are passed on for reanalysis with the full HMM Forward/Backward algorithm. This accelerated pipeline is implemented in the freely available HMMER3 software package. Performance benchmarks show that the use of the heuristic MSV filter sacrifices negligible sensitivity compared to unaccelerated profile HMM searches. HMMER3 is substantially more sensitive and 100- to 1000-fold faster than HMMER2. HMMER3 is now about as fast as BLAST for protein searches.

microMS: A Python Platform for Image-Guided Mass Spectrometry Profiling

Science.gov (United States)

Comi, Troy J.; Neumann, Elizabeth K.; Do, Thanh D.; Sweedler, Jonathan V.

2017-09-01

Image-guided mass spectrometry (MS) profiling provides a facile framework for analyzing samples ranging from single cells to tissue sections. The fundamental workflow utilizes a whole-slide microscopy image to select targets of interest, determine their spatial locations, and subsequently perform MS analysis at those locations. Improving upon prior reported methodology, a software package was developed for working with microscopy images. microMS, for microscopy-guided mass spectrometry, allows the user to select and profile diverse samples using a variety of target patterns and mass analyzers. Written in Python, the program provides an intuitive graphical user interface to simplify image-guided MS for novice users. The class hierarchy of instrument interactions permits integration of new MS systems while retaining the feature-rich image analysis framework. microMS is a versatile platform for performing targeted profiling experiments using a series of mass spectrometers. The flexibility in mass analyzers greatly simplifies serial analyses of the same targets by different instruments. The current capabilities of microMS are presented, and its application for off-line analysis of single cells on three distinct instruments is demonstrated. The software has been made freely available for research purposes. [Figure not available: see fulltext.

Profiling the Mobile Customer

DEFF Research Database (Denmark)

Jessen, Pernille Wegener; King, Nancy J.

2010-01-01

of significant concerns about privacy and data protection. This second article in a two part series on "Profiling the Mobile Customer" explores how to best protect consumers' privacy and personal data through available mechanisms that include industry self-regulation, privacy-enhancing technologies...... discusses the current limitations of using technology to protect consumers from privacy abuses related to profiling. Concluding that industry self-regulation and available privacy-enhancing technologies will not be adequate to close important privacy gaps related to consumer profiling without legislative...

Character profiles and life satisfaction.

Science.gov (United States)

Park, Hwanjin; Suh, Byung Seong; Kim, Won Sool; Lee, Hye-Kyung; Park, Seon-Cheol; Lee, Kounseok

2015-04-01

There is a surge of interest in subjective well-being (SWB), which concerns how individuals feel about their happiness. Life satisfaction tends to be influenced by individual psychological traits and external social factors. The aim of this study was to examine the relationship between individual character and SWB. Data from 3522 university students were analyzed in this study. Character profiles were evaluated using the Temperament and Character Inventory-Revised Short version (TCI-RS). Life satisfaction was assessed using the Satisfaction with Life Scale (SWLS). All statistical tests regarding the correlations between each character profile and life satisfaction were conducted using ANOVAs, t-tests, multiple linear regression models and correlation analyses. The creative (SCT) profile was associated with the highest levels of life satisfaction, whereas the depressive (sct) profile was associated with the lowest levels of life satisfaction. Additionally, high self-directedness, self-transcendence and cooperation were associated with high life satisfaction. The results of gender-adjusted multiple regression analysis showed that the effects of self-directedness were the strongest in the assessment of one's quality of life, followed by self-transcendence and cooperativeness, in that order. All of the three-character profiles were significantly correlated with one's quality of life, and the character profiles of TCI-RS explained 27.6% of life satisfaction in total. Among the three-character profiles, the self-directedness profile was most associated with life satisfaction. Our study was cross-sectional, and self-reported data from students at a single university were analyzed. The results of this study showed that, among the character profiles, the effects of self-directedness were the strongest for predicting life satisfaction. Copyright © 2014 Elsevier Inc. All rights reserved.

User profiles and personas in the design and development of consumer health technologies.

Science.gov (United States)

LeRouge, Cynthia; Ma, Jiao; Sneha, Sweta; Tolle, Kristin

2013-11-01

complement traditional user profile and persona techniques for CHT design by integrating cognitive structures and present behavior that drive health care thinking, future behavior and demand; (3) show how the profiles and personas can be used to inform requirements, design and implementation decisions for a technology aimed at facilitating CHT adoption and diffusion for the elderly. To exemplify process and application, we use an action-research methodology, where user profiles and personas of an aging patient population were developed. The resultant profiles and personas were leveraged to improve the design, development and implementation plans of a smart phone application to assist chronically ill aging Chinese diabetic population capable of disease self-management. The results from the study show that user profile and persona can be a valuable methodological approach in capturing the conceptual model of the aging and informing the design and development decisions of CHT. The demonstration of techniques used in this study can serve as a guideline to CHT developers in bringing conceptual user modeling into the design of software interfaces targeted for users with specific health care needs. Specifically, the study provides guidance on the creation and use of profiles and personas to tap into the conceptual models of the targeted elderly population reflecting their preferences, capabilities and attitudes towards using technology in self-management care in general and the smart phone diabetes management application in particular. Insight into the mental model of the aging group has been shown to inform later stages of UCD development (e.g., the creation of prototypes and usability testing) as well as implementation and adoption strategies. The World Health Organization (WHO) predicts that by 2025, 80% of all new cases of diabetes are expected to appear in the developing countries. In fact, the number of diabetic patients in China is estimated to rise to 42.3 million in 2030

Versatile Gene-Specific Sequence Tags for Arabidopsis Functional Genomics: Transcript Profiling and Reverse Genetics Applications

Science.gov (United States)

Hilson, Pierre; Allemeersch, Joke; Altmann, Thomas; Aubourg, Sébastien; Avon, Alexandra; Beynon, Jim; Bhalerao, Rishikesh P.; Bitton, Frédérique; Caboche, Michel; Cannoot, Bernard; Chardakov, Vasil; Cognet-Holliger, Cécile; Colot, Vincent; Crowe, Mark; Darimont, Caroline; Durinck, Steffen; Eickhoff, Holger; de Longevialle, Andéol Falcon; Farmer, Edward E.; Grant, Murray; Kuiper, Martin T.R.; Lehrach, Hans; Léon, Céline; Leyva, Antonio; Lundeberg, Joakim; Lurin, Claire; Moreau, Yves; Nietfeld, Wilfried; Paz-Ares, Javier; Reymond, Philippe; Rouzé, Pierre; Sandberg, Goran; Segura, Maria Dolores; Serizet, Carine; Tabrett, Alexandra; Taconnat, Ludivine; Thareau, Vincent; Van Hummelen, Paul; Vercruysse, Steven; Vuylsteke, Marnik; Weingartner, Magdalena; Weisbeek, Peter J.; Wirta, Valtteri; Wittink, Floyd R.A.; Zabeau, Marc; Small, Ian

2004-01-01

Microarray transcript profiling and RNA interference are two new technologies crucial for large-scale gene function studies in multicellular eukaryotes. Both rely on sequence-specific hybridization between complementary nucleic acid strands, inciting us to create a collection of gene-specific sequence tags (GSTs) representing at least 21,500 Arabidopsis genes and which are compatible with both approaches. The GSTs were carefully selected to ensure that each of them shared no significant similarity with any other region in the Arabidopsis genome. They were synthesized by PCR amplification from genomic DNA. Spotted microarrays fabricated from the GSTs show good dynamic range, specificity, and sensitivity in transcript profiling experiments. The GSTs have also been transferred to bacterial plasmid vectors via recombinational cloning protocols. These cloned GSTs constitute the ideal starting point for a variety of functional approaches, including reverse genetics. We have subcloned GSTs on a large scale into vectors designed for gene silencing in plant cells. We show that in planta expression of GST hairpin RNA results in the expected phenotypes in silenced Arabidopsis lines. These versatile GST resources provide novel and powerful tools for functional genomics. PMID:15489341

Observation of the skin-like profiles of electron temperature and density of turbulently heated plasmas in the TRIAM-1 tokamak

International Nuclear Information System (INIS)

Hiraki, Naoji; Nakamura, Kazuo; Toi, Kazuo; Itoh, Satoshi

1980-01-01

The time evolution of electron temperature and density profiles are measured on the turbulent heating experiment in the TRIAM-1 tokamak. The skin-like profiles of electron temperature and density are observed just after the application of the pulsed electric field for turbulent heating. The width of the skin layer of the electron temperature profile is about 1 cm, and agrees well with the theoretical value. The above mentioned skin heating of electrons just after the heating pulse is also spectroscopically confirmed by the remarkable decrease of the volume emission of visible lines which is localized at the outer plasma region. (author)

Observation of the skin-like profiles of electron temperature and density of turbulently heated plasmas in the TRIAM-1 tokamak

Energy Technology Data Exchange (ETDEWEB)

Hiraki, N; Nakamura, K; Toi, K; Itoh, S [Kyushu Univ., Fukuoka (Japan). Research Inst. for Applied Mechanics

1980-07-01

The time evolution of electron temperature and density profiles are measured on the turbulent heating experiment in the TRIAM-1 tokamak. The skin-like profiles of electron temperature and density are observed just after the application of the pulsed electric field for turbulent heating. The width of the skin layer of the electron temperature profile is about 1 cm, and agrees well with the theoretical value. The above mentioned skin heating of electrons just after the heating pulse is also spectroscopically confirmed by the remarkable decrease of the volume emission of visible lines which is localized at the outer plasma region.

Dosimetry analysis of distributions radials dose profiles of {sup 90}Sr + {sup 90}Y beta therapy applicators using the MCNP-4C code and radio chromium films; Analise dosimetrica de perfis de distribuicoes radias de doses relativas de um aplicador de betaterapia de {sup 90}Sr + {sup 90}Y utilizando o codigo MCNP-4C e filmes radiocromicos

Energy Technology Data Exchange (ETDEWEB)

Coelho, Talita S.; Yoriyaz, Helio [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Fernandes, Marco A.R., E-mail: tasallesc@gmail.co [UNESP, Botucatu, SP (Brazil). Faculdade de Medicina. Servico de Radioterapia; Louzada, Mario J.Q. [UNESP, Aracatuba, SP (Brazil). Curso de Medicina Veterinaria

2011-07-01

Although they are no longer manufactured, the applicators of {sup 90}Sr + {sup 90}Y acquired in the decades of 1990 are still in use, by having half-life of 28.5 years. These applicators have calibration certificate given by their manufacturers, where few have been re calibrated. Thus it becomes necessary to accomplish thorough dosimetry of these applicators. This paper presents a dosimetric analysis distribution radial dose profiles for emitted by an {sup 90}Sr + {sup 90}Y beta therapy applicator, using the MCNP-4C code to simulate the distribution radial dose profiles and radio chromium films to get them experimentally . The results with the simulated values were compared with the results of experimental measurements, where both curves show similar behavior, which may validate the use of MCNP-4C and radio chromium films for this type of dosimetry. (author)

Dosimetry analysis of distribution radial dose profiles of {sup 90}Sr + {sup 90}Y beta therapy applicators using the MCNP-4C code and radio chromium films; Analise dosimetrica de perfis de distribuicoes radiais de doses relativas de um aplicador de betaterapia de {sup 90}Sr + {sup 90}Y utilizando o codigo MCNP-4C e filmes radiocromicos

Energy Technology Data Exchange (ETDEWEB)

Coelho, T.S.; Yoriyaz, H. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Fernandes, M.A.R. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil). Fac. de Medicina. Servico de Radioterapia; Louzada, M.J.Q. [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Aracatuba, SP (Brazil). Curso de Medicina Veterinaria

2010-07-01

Although they are no longer manufactured, the applicators of {sup 90}Sr +{sup 90}Y acquired in the decades of 1990 are still in use, by having half-life of 28.5 years. These applicators have calibration certificate given by their manufacturers, where few have been recalibrated. Thus it becomes necessary to accomplish thorough dosimetry of these applicators. This paper presents a dosimetric analysis distribution radial dose profiles for emitted by an {sup 90}Sr+{sup 90}Y beta therapy applicator, using the MCNP-4C code to simulate the distribution radial dose profiles and radiochromium films to get them experimentally . The results with the simulated values were compared with the results of experimental measurements, where both curves show similar behavior, which may validate the use of MCNP-4C and radiochromium films for this type of dosimetry. (author)

Visual Modelling of Data Warehousing Flows with UML Profiles

Science.gov (United States)

Pardillo, Jesús; Golfarelli, Matteo; Rizzi, Stefano; Trujillo, Juan

Data warehousing involves complex processes that transform source data through several stages to deliver suitable information ready to be analysed. Though many techniques for visual modelling of data warehouses from the static point of view have been devised, only few attempts have been made to model the data flows involved in a data warehousing process. Besides, each attempt was mainly aimed at a specific application, such as ETL, OLAP, what-if analysis, data mining. Data flows are typically very complex in this domain; for this reason, we argue, designers would greatly benefit from a technique for uniformly modelling data warehousing flows for all applications. In this paper, we propose an integrated visual modelling technique for data cubes and data flows. This technique is based on UML profiling; its feasibility is evaluated by means of a prototype implementation.

SPK Rekomendasi Pemilihan Kandidat Pejabat Struktural Menggunakan Metode Profile Matching (Studi Kasus: Pemerintah Kota Tarakan

Directory of Open Access Journals (Sweden)

Ria Astriratma

2017-01-01

Full Text Available Through the State Civil Apparatus Law, the Government attempt to reduce nepotism by creating an open competition system among civil servants in the process of filling positions. Regional Civil Service Agency (BKD Tarakan already has personnel database and decision support system that can combine the existing database with the scoring model to get the candicate profile who fit with vacant positions is needed to support more objective performance. The Application of profile matching method in this decision support system is expected to help the candidate selection process on structural officer in the Government of Tarakan comply with the ability of a required field in a position. From the research we concluded that the change in the value of the candicate profile, and the number of subcriteria that used to categorize the positions can affect the closeness of candidates with vacant position and the use of profile matching method for case that the highest value is the best value requires that the ideal value used is the value the maximum in order to avoid exceeding the expectations of ideal.

End-threaded intramedullary positive profile screw ended self-tapping pin (Admit pin) - A cost-effective novel implant for fixing canine long bone fractures.

Science.gov (United States)

Chanana, Mitin; Kumar, Adarsh; Tyagi, Som Prakash; Singla, Amit Kumar; Sharma, Arvind; Farooq, Uiase Bin

2018-02-01

The current study was undertaken to evaluate the clinical efficacy of end-threaded intramedullary pinning for management of various long bone fractures in canines. This study was conducted in two phases, managing 25 client-owned dogs presented with different fractures. The technique of application of end-threaded intramedullary pinning in long bone fractures was initially standardized in 6 clinical patients presented with long bone fractures. In this phase, end-threaded pins of different profiles, i.e., positive and negative, were used as the internal fixation technique. On the basis of results obtained from standardization phase, 19 client-owned dogs clinically presented with different fractures were implanted with end-threaded intramedullary positive profile screw ended self-tapping pin in the clinical application phase. The patients, allocated randomly in two groups, when evaluated postoperatively revealed slight pin migration in Group-I (negative profile), which resulted in disruption of callus site causing delayed union in one case and large callus formation in other two cases whereas no pin migration was observed in Group-II (positive profile). Other observations in Group-I was reduced muscle girth and delayed healing time as compared to Group-II. In clinical application, phase 21 st and 42 nd day post-operative radiographic follow-up revealed no pin migration in any of the cases, and there was no bone shortening or fragment collapse in end-threaded intramedullary positive profile screw ended self-tapping pin. The end-threaded intramedullary positive profile screw ended self-tapping pin used for fixation of long bone fractures in canines can resist pin migration, pin breakage, and all loads acting on the bone, i.e., compression, tension, bending, rotation, and shearing to an extent with no post-operative complications.

Interstrain polymorphisms of isoenzyme profiles and mitochondrial DNA fingerprints among seven strains assigned to Acanthamoeba polyphaga.

Science.gov (United States)

Kong, H H; Park, J H; Chung, D I

1995-12-01

Interstrain polymorphisms of isoenzyme profiles and mitochondrial (Mt) DNA fingerprints were observed among seven strains of Acanthamoeba isolated from different sources and morphologically assigned to A. polyphaga. Mt DNA fingerprints by eight restriction endonucleases (Bgl II, Sca I, Cla I, EcoR I, Xba I, Kpn I, Sal I, and Sst I) revealed considerable interstrain polymorphisms. Isoenzyme profiles revealed considerable interstrain polymorphisms for acid phosphatase, lactate dehydrogenase, and glucose-6-phosphate dehydrogenase while those for glucose phosphate isomerase, leucine aminopeptidase, and malate dehydrogenase showed similarity. Despite of the interstrain polymorphisms, the isoenzyme profiles and Mt DNA fingerprints of the strain Ap were found to be identical with those of the strain Jones. Mt DNA fingerprinting was found to be highly applicable for the strain identification, characterization, and differentiation.

Quantum Dot Platform for Single-Cell Molecular Profiling

Science.gov (United States)

Zrazhevskiy, Pavel S.

preparation and specimen labeling, requiring no advanced technical skills and being directly applicable for a wide range of molecular profiling studies. Utilization of quantum dot platform for single-cell molecular profiling promises to greatly benefit both biomedical research and clinical diagnostics by providing a tool for addressing phenotypic heterogeneity within large cell populations, opening access to studying low-abundance events often masked or completely erased by batch processing, and elucidating biomarker signatures of diseases critical for accurate diagnostics and targeted therapy.

Use of profile hidden Markov models in viral discovery: current insights

Directory of Open Access Journals (Sweden)

Reyes A

2017-07-01

efficacy of the models. One of the interesting applications of viral profile HMMs is the detection and sequence reconstruction of specific viral genomes from metagenomic data. In fact, several DNA assembly programs that use profile HMMs as seeds have been developed to identify and build gene-sized assemblies or viral genome sequences of unrestrained length, using conventional and progressive assembly approaches, respectively. In this review, we address these aspects and cover some up-to-date information on viral genomics that should be considered in the choice of molecular markers for viral discovery. Finally, we propose a roadmap for rational development of viral profile HMMs and discuss the main challenges associated with this task. Keywords: profile hidden Markov models, viral discovery, DNA assembly, metagenomic analysis, molecular markers, de novo diagnosis 

Parameter selection for peak alignment in chromatographic sample profiling: Objective quality indicators and use of control samples

NARCIS (Netherlands)

Peters, S.; van Velzen, E.; Janssen, H.-G.

2009-01-01

In chromatographic profiling applications, peak alignment is often essential as most chromatographic systems exhibit small peak shifts over time. When using currently available alignment algorithms, there are several parameters that determine the outcome of the alignment process. Selecting the

A LVDT conditioner for the beam profile monitors of the AmPS

International Nuclear Information System (INIS)

Es, J.T. van; Trigt, J.H. van.

1991-01-01

A LVDT (Linear Variable Differential Transformer) is a transducer for localization. Because of its applied materials, its construction and the absence of bearings etc. the instrument is suitable to be applied in locations where radioactive radiation is present. In order to obtain information about the position of the iron core in the transducer, a conditioner is needed. In 1977 by Digel a conditioner has been developed for the beam profile monitors (moving wire) of MEA because the 'market' could not meet the requirements then. Nowadays the 'market' offers i.c.'s which can take over the work of the Eurocard developed then. Digel has investigated them in order to see if they are applicable for the beam profile monitors of AmPS. (author). 5 refs.; 7 figs.; 13 tabs

Serum protein profiling by miniaturized solid-phase extraction and matrix-assisted laser desorption/ionization mass spectrometry

DEFF Research Database (Denmark)

Callesen, Anne K; Mohammed, Shabaz; Bunkenborg, Jakob

2005-01-01

for translation of MALDI-MS based diagnostic methods to clinical applications. We have investigated a number of MALDI matrices and several miniaturized solid-phase extraction (SPE) methods for serum protein concentration and desalting with the aim of generating reproducible, high-quality protein profiles by MALDI...

High-Specificity Targeted Functional Profiling in Microbial Communities with ShortBRED.

Directory of Open Access Journals (Sweden)

James Kaminski

2015-12-01

Full Text Available Profiling microbial community function from metagenomic sequencing data remains a computationally challenging problem. Mapping millions of DNA reads from such samples to reference protein databases requires long run-times, and short read lengths can result in spurious hits to unrelated proteins (loss of specificity. We developed ShortBRED (Short, Better Representative Extract Dataset to address these challenges, facilitating fast, accurate functional profiling of metagenomic samples. ShortBRED consists of two components: (i a method that reduces reference proteins of interest to short, highly representative amino acid sequences ("markers" and (ii a search step that maps reads to these markers to quantify the relative abundance of their associated proteins. After evaluating ShortBRED on synthetic data, we applied it to profile antibiotic resistance protein families in the gut microbiomes of individuals from the United States, China, Malawi, and Venezuela. Our results support antibiotic resistance as a core function in the human gut microbiome, with tetracycline-resistant ribosomal protection proteins and Class A beta-lactamases being the most widely distributed resistance mechanisms worldwide. ShortBRED markers are applicable to other homology-based search tasks, which we demonstrate here by identifying phylogenetic signatures of antibiotic resistance across more than 3,000 microbial isolate genomes. ShortBRED can be applied to profile a wide variety of protein families of interest; the software, source code, and documentation are available for download at http://huttenhower.sph.harvard.edu/shortbred.

Towards Current Profile Control in ITER: Potential Approaches and Research Needs

Science.gov (United States)

Schuster, E.; Barton, J. E.; Wehner, W. P.

2014-10-01

Many challenging plasma control problems still need to be addressed in order for the ITER Plasma Control System (PCS) to be able to successfully achieve the ITER project goals. For instance, setting up a suitable toroidal current density profile is key for one possible advanced scenario characterized by noninductive sustainment of the plasma current and steady-state operation. The nonlinearity and high dimensionality exhibited by the plasma demand a model-based current-profile control synthesis procedure that can accommodate this complexity through embedding the known physics within the design. The development of a model capturing the dynamics of the plasma relevant for control design enables not only the design of feedback controllers for regulation or tracking but also the design of optimal feedforward controllers for a systematic model-based approach to scenario planning, the design of state estimators for a reliable real-time reconstruction of the plasma internal profiles based on limited and noisy diagnostics, and the development of a fast predictive simulation code for closed-loop performance evaluation before implementation. Progress towards control-oriented modeling of the current profile evolution and associated control design has been reported following both data-driven and first-principles-driven approaches. An overview of these two approaches will be provided, as well as a discussion on research needs associated with each one of the model applications described above. Supported by the US Department of Energy under DE-SC0001334 and DE-SC0010661.

Depth-profiling using X-ray photoelectron spectroscopy

International Nuclear Information System (INIS)

Pijolat, M.; Hollinger, G.

1980-12-01

The possibilities of X-ray photoelectron spectroscopy (or ESCA) for depth-profiling into shallow depths (approximately 10-100 A) have been studied. The method of ion-sputtering removal has first been investigated in order to improve its depth-resolution (approximately 50-150 A). A procedure which eliminates the effects due to the resolution function of the instrumental probe (analysed depth approximately 50 A) has been settled; but it is not yet sufficient, and the sputter - broadening due to the ion-induced damages must be taken into account (broadening function approximately 50 A for approximately 150 A removal). Because of serious difficulties in estimating the broadening function an alternative is to develop non destructive methods, so a new method based on the dependence of the analysed depth with the electron emission angle is presented. The extraction of the concentration profile from angular distribution experiments is achieved, in the framework of a flat-layer model, by minimizing the difference between theoretical and experimental relative intensities. The applicability and limitations of the method are discussed on the basis of computer simulation results. The depth probed is of the order of 3 lambda (lambda being the value of the inelastic mean free path, typically 10-20 A) and the depth-resolution is of the order of lambda/3 [fr

Influence of exposure to pesticide mixtures on the metabolomic profile in post-metamorphic green frogs (Lithobates clamitans)

Science.gov (United States)

Pesticide use in agricultural areas requires the application of numerous chemicals to control target organisms, leaving non-target organisms at risk. The present study evaluates the hepatic metabolomic profile of one group of non-target organisms, amphibians, after exposure to a ...

Ohmic ion temperature and thermal diffusivity profiles from the JET neutron emission profile monitor

Energy Technology Data Exchange (ETDEWEB)

Esposito, B. (ENEA, Frascati (Italy). Centro Ricerche Energia); Marcus, F.B.; Conroy, S.; Jarvis, O.N.; Loughlin, M.J.; Sadler, G.; Belle, P. van (Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking); Adams, J.M.; Watkins, N. (AEA Industrial Technology, Harwell (United Kingdom))

1993-10-01

The JET neutron emission profile monitor was used to study ohmically heated deuterium discharges. The radial profile of the neutron emissivity is deduced from the line-integral data. The profiles of ion temperature, T[sub i], and ion thermal diffusivity, [chi][sub i], are derived under steady-state conditions. The ion thermal diffusivity is higher than, and its scaling with plasma current opposite to, that predicted by neoclassical theory. (author).

Ohmic ion temperature and thermal diffusivity profiles from the JET neutron emission profile monitor

International Nuclear Information System (INIS)

Esposito, B.

1993-01-01

The JET neutron emission profile monitor was used to study ohmically heated deuterium discharges. The radial profile of the neutron emissivity is deduced from the line-integral data. The profiles of ion temperature, T i , and ion thermal diffusivity, χ i , are derived under steady-state conditions. The ion thermal diffusivity is higher than, and its scaling with plasma current opposite to, that predicted by neoclassical theory. (author)

Light vehicle crash avoidance needs and countermeasure profiles for safety applications based on vehicle-to-vehicle communications

Science.gov (United States)

2013-04-30

This report discusses light-vehicle crash countermeasure profiles and functions for five target pre-crash scenario groups based on vehicle-to-vehicle (V2V) communications. Target pre-crash scenario groups include rear-end, lane change, opposite direc...

Focused ion-beam line profiles: A study of some factors affecting beam broadening

International Nuclear Information System (INIS)

Templeton, I.M.; Champion, H.G.

1995-01-01

The current--density profile of a focused ion beam (FIB) has a central peak accompanied by broader ''wings'' that, while unimportant in lithographic applications, can lead to unwanted effects during an implantation operation. The origin of the wings, and hence the best way to minimize them, is not clear and needs further study. We have measured the line profiles of several of the ions available in our FIB machine as a function of a number of variables, under ultrahigh vacuum (UHV) conditions. No effects are observed from changes in emission current or deliberate defocusing of the objective lens. There are some changes with beam aperture and/or current, but the biggest differences seem to be associated with a change of source type and hence, possibly, with a change in the source/extractor configuration or in the alloy and the emission process. The wing amplitudes are appreciably lower than many previously observed, and their profiles, at least for the lighter ions studied (Be ++ , Be + , and B + ), are Gaussian rather than exponential. It seems possible that our UHV conditions may have eliminated a scattering mechanism responsible for the larger, exponential wings previously observed. The corresponding beam and rectangle-edge profiles have been calculated. copyright 1995 American Vacuum Society

Local flow management/profile descent algorithm. Fuel-efficient, time-controlled profiles for the NASA TSRV airplane

Science.gov (United States)

Groce, J. L.; Izumi, K. H.; Markham, C. H.; Schwab, R. W.; Thompson, J. L.

1986-01-01

The Local Flow Management/Profile Descent (LFM/PD) algorithm designed for the NASA Transport System Research Vehicle program is described. The algorithm provides fuel-efficient altitude and airspeed profiles consistent with ATC restrictions in a time-based metering environment over a fixed ground track. The model design constraints include accommodation of both published profile descent procedures and unpublished profile descents, incorporation of fuel efficiency as a flight profile criterion, operation within the performance capabilities of the Boeing 737-100 airplane with JT8D-7 engines, and conformity to standard air traffic navigation and control procedures. Holding and path stretching capabilities are included for long delay situations.

Phase shifting white light interferometry using colour CCD for optical metrology and bio-imaging applications

Science.gov (United States)

Upputuri, Paul Kumar; Pramanik, Manojit

2018-02-01

Phase shifting white light interferometry (PSWLI) has been widely used for optical metrology applications because of their precision, reliability, and versatility. White light interferometry using monochrome CCD makes the measurement process slow for metrology applications. WLI integrated with Red-Green-Blue (RGB) CCD camera is finding imaging applications in the fields optical metrology and bio-imaging. Wavelength dependent refractive index profiles of biological samples were computed from colour white light interferograms. In recent years, whole-filed refractive index profiles of red blood cells (RBCs), onion skin, fish cornea, etc. were measured from RGB interferograms. In this paper, we discuss the bio-imaging applications of colour CCD based white light interferometry. The approach makes the measurement faster, easier, cost-effective, and even dynamic by using single fringe analysis methods, for industrial applications.

Development and validation of a skin fibroblast biomarker profile for schizophrenic patients

Directory of Open Access Journals (Sweden)

Marianthi Logotheti

2016-12-01

Full Text Available Gene expression profiles of non-neural tissues through microarray technology could be used in schizophrenia studies, adding more information to the results from similar studies on postmortem brain tissue. The ultimate goal of such studies is to develop accessible biomarkers. Supervised machine learning methodologies were used, in order to examine if the gene expression from skin fibroblast cells could be exploited for the classification of schizophrenic subjects. A dataset of skin fibroblasts gene expression of schizophrenia patients was obtained from Gene Expression Omnibus database. After applying statistical criteria, we concluded to genes that present a differential expression between the schizophrenic patients and the healthy controls. Based on those genes, functional profiling was performed with the BioInfoMiner web tool. After the statistical analysis, 63 genes were identified as differentially expressed. The functional profiling revealed interesting terms and pathways, such as mitogen activated protein kinase and cyclic adenosine monophosphate signaling pathways, as well as immune-related mechanisms. A subset of 16 differentially expressed genes from fibroblast gene expression profiling that occurred after Support Vector Machines Recursive Feature Elimination could efficiently separate schizophrenic from healthy controls subjects. These findings suggest that through the analysis of fibroblast based gene expression signature and with the application of machine learning methodologies we might conclude to a diagnostic classification model in schizophrenia.

Metabolic profiling of meat: assessment of pork hygiene and contamination with Salmonella typhimurium.

Science.gov (United States)

Xu, Yun; Cheung, William; Winder, Catherine L; Dunn, Warwick B; Goodacre, Royston

2011-02-07

Spoilage in meat is the result of the action of microorganisms and results in changes of meat and microbial metabolism. This process may include pathogenic food poisoning bacteria such as Salmonella typhimurium, and it is important that these are differentiated from the natural spoilage process caused by non-pathogenic microorganisms. In this study we investigated the application of metabolic profiling using gas chromatography-mass spectrometry, to assess the microbial contamination of pork. Metabolite profiles were generated from microorganisms, originating from the natural spoilage process and from the artificial contamination with S. typhimurium. In an initial experiment, we investigated changes in the metabolic profiles over a 72 hour time course at 25 °C and established time points indicative of the spoilage process. A further experiment was performed to provide in-depth analysis of the metabolites characteristic of contamination by S. typhimurium. We applied a three-way PARAllel FACtor analysis 2 (PARAFAC2) multivariate algorithm to model the metabolic profiles. In addition, two univariate statistical tests, two-sample Wilcoxon signed rank test and Friedman test, were employed to identify metabolites which showed significant difference between natural spoiled and S. typhimurium contaminated samples. Consistent results from the two independent experiments were obtained showing the discrimination of the metabolic profiles of the natural spoiled pork chops and those contaminated with S. typhimurium. The analysis identified 17 metabolites of significant interest (including various types of amino acid and fatty acid) in the discrimination of pork contaminated with the pathogenic microorganism.

Multilineage potential and proteomic profiling of human dental stem cells derived from a single donor

International Nuclear Information System (INIS)

Patil, Rajreddy; Kumar, B. Mohana; Lee, Won-Jae; Jeon, Ryoung-Hoon; Jang, Si-Jung; Lee, Yeon-Mi; Park, Bong-Wook; Byun, June-Ho; Ahn, Chun-Seob; Kim, Jae-Won; Rho, Gyu-Jin

2014-01-01

Dental tissues provide an alternative autologous source of mesenchymal stem cells (MSCs) for regenerative medicine. In this study, we isolated human dental MSCs of follicle, pulp and papilla tissue from a single donor tooth after impacted third molar extraction by excluding the individual differences. We then compared the morphology, proliferation rate, expression of MSC-specific and pluripotency markers, and in vitro differentiation ability into osteoblasts, adipocytes, chondrocytes and functional hepatocyte-like cells (HLCs). Finally, we analyzed the protein expression profiles of undifferentiated dental MSCs using 2DE coupled with MALDI-TOF-MS. Three types of dental MSCs largely shared similar morphology, proliferation potential, expression of surface markers and pluripotent transcription factors, and differentiation ability into osteoblasts, adipocytes, and chondrocytes. Upon hepatogenic induction, all MSCs were transdifferentiated into functional HLCs, and acquired hepatocyte functions by showing their ability for glycogen storage and urea production. Based on the proteome profiling results, we identified nineteen proteins either found commonly or differentially expressed among the three types of dental MSCs. In conclusion, three kinds of dental MSCs from a single donor tooth possessed largely similar cellular properties and multilineage potential. Further, these dental MSCs had similar proteomic profiles, suggesting their interchangeable applications for basic research and call therapy. - Highlights: • Isolated and characterized three types of human dental MSCs from a single donor. • MSCs of dental follicle, pulp and papilla had largely similar biological properties. • All MSCs were capable of transdifferentiating into functional hepatocyte-like cells. • 2DE proteomics with MALDI-TOF/MS identified 19 proteins in three types of MSCs. • Similar proteomic profiles suggest interchangeable applications of dental MSCs

Multilineage potential and proteomic profiling of human dental stem cells derived from a single donor

Energy Technology Data Exchange (ETDEWEB)

Patil, Rajreddy; Kumar, B. Mohana; Lee, Won-Jae; Jeon, Ryoung-Hoon; Jang, Si-Jung; Lee, Yeon-Mi [Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701 (Korea, Republic of); Park, Bong-Wook; Byun, June-Ho [Department of Oral and Maxillofacial Surgery, School of Medicine and Institute of Health Science, Gyeongsang National University, Jinju 660-702 (Korea, Republic of); Ahn, Chun-Seob; Kim, Jae-Won [Department of Microbiology, Division of Life Sciences, Research Institute of Life Science, Gyeongsang National University, Jinju 660-701 (Korea, Republic of); Rho, Gyu-Jin, E-mail: jinrho@gnu.ac.kr [Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701 (Korea, Republic of); Research Institute of Life Sciences, Gyeongsang National University, Jinju 660-701 (Korea, Republic of)

2014-01-01

Dental tissues provide an alternative autologous source of mesenchymal stem cells (MSCs) for regenerative medicine. In this study, we isolated human dental MSCs of follicle, pulp and papilla tissue from a single donor tooth after impacted third molar extraction by excluding the individual differences. We then compared the morphology, proliferation rate, expression of MSC-specific and pluripotency markers, and in vitro differentiation ability into osteoblasts, adipocytes, chondrocytes and functional hepatocyte-like cells (HLCs). Finally, we analyzed the protein expression profiles of undifferentiated dental MSCs using 2DE coupled with MALDI-TOF-MS. Three types of dental MSCs largely shared similar morphology, proliferation potential, expression of surface markers and pluripotent transcription factors, and differentiation ability into osteoblasts, adipocytes, and chondrocytes. Upon hepatogenic induction, all MSCs were transdifferentiated into functional HLCs, and acquired hepatocyte functions by showing their ability for glycogen storage and urea production. Based on the proteome profiling results, we identified nineteen proteins either found commonly or differentially expressed among the three types of dental MSCs. In conclusion, three kinds of dental MSCs from a single donor tooth possessed largely similar cellular properties and multilineage potential. Further, these dental MSCs had similar proteomic profiles, suggesting their interchangeable applications for basic research and call therapy. - Highlights: • Isolated and characterized three types of human dental MSCs from a single donor. • MSCs of dental follicle, pulp and papilla had largely similar biological properties. • All MSCs were capable of transdifferentiating into functional hepatocyte-like cells. • 2DE proteomics with MALDI-TOF/MS identified 19 proteins in three types of MSCs. • Similar proteomic profiles suggest interchangeable applications of dental MSCs.

Single molecule transcription profiling with AFM

International Nuclear Information System (INIS)

Reed, Jason; Mishra, Bud; Pittenger, Bede; Magonov, Sergei; Troke, Joshua; Teitell, Michael A; Gimzewski, James K

2007-01-01

Established techniques for global gene expression profiling, such as microarrays, face fundamental sensitivity constraints. Due to greatly increasing interest in examining minute samples from micro-dissected tissues, including single cells, unorthodox approaches, including molecular nanotechnologies, are being explored in this application. Here, we examine the use of single molecule, ordered restriction mapping, combined with AFM, to measure gene transcription levels from very low abundance samples. We frame the problem mathematically, using coding theory, and present an analysis of the critical error sources that may serve as a guide to designing future studies. We follow with experiments detailing the construction of high density, single molecule, ordered restriction maps from plasmids and from cDNA molecules, using two different enzymes, a result not previously reported. We discuss these results in the context of our calculations

Assembly of tantalum porous films with graded oxidation profile from size-selected nanoparticles

Science.gov (United States)

Singh, Vidyadhar; Grammatikopoulos, Panagiotis; Cassidy, Cathal; Benelmekki, Maria; Bohra, Murtaza; Hawash, Zafer; Baughman, Kenneth W.; Sowwan, Mukhles

2014-05-01

Functionally graded materials offer a way to improve the physical and chemical properties of thin films and coatings for different applications in the nanotechnology and biomedical fields. In this work, design and assembly of nanoporous tantalum films with a graded oxidation profile perpendicular to the substrate surface are reported. These nanoporous films are composed of size-selected, amorphous tantalum nanoparticles, deposited using a gas-aggregated magnetron sputtering system, and oxidized after coalescence, as samples evolve from mono- to multi-layered structures. Molecular dynamics computer simulations shed light on atomistic mechanisms of nanoparticle coalescence, which govern the films porosity. Aberration-corrected (S) TEM, GIXRD, AFM, SEM, and XPS were employed to study the morphology, phase and oxidation profiles of the tantalum nanoparticles, and the resultant films.

Size-dependent mortality rate profiles.

Science.gov (United States)

Roa-Ureta, Ruben H

2016-08-07

Knowledge of mortality rates is crucial to the understanding of population dynamics in populations of free-living fish and invertebrates in marine and freshwater environments, and consequently to sustainable resource management. There is a well developed theory of population dynamics based on age distributions that allow direct estimation of mortality rates. However, for most cases the aging of individuals is difficult or age distributions are not available for other reasons. The body size distribution is a widely available alternative although the theory underlying the formation of its shape is more complicated than in the case of age distributions. A solid theory of the time evolution of a population structured by any physiological variable has been developed in 1960s and 1970s by adapting the Hamilton-Jacobi formulation of classical mechanics, and equations to estimate the body size-distributed mortality profile have been derived for simple cases. Here I extend those results with regards to the size-distributed mortality profile to complex cases of non-stationary populations, individuals growing according to a generalised growth model and seasonally patterned recruitment pulses. I apply resulting methods to two cases in the marine environment, a benthic crustacean population that was growing during the period of observation and whose individuals grow with negative acceleration, and a sea urchin coastal population that is undergoing a stable cycle of two equilibrium points in population size whose individuals grow with varying acceleration that switches sign along the size range. The extension is very general and substantially widens the applicability of the theory. Copyright © 2016 Elsevier Ltd. All rights reserved.

The influence of the residency application process on the online social networking behavior of medical students: a single institutional study.

Science.gov (United States)

Strausburg, Matthew B; Djuricich, Alexander M; Carlos, W Graham; Bosslet, Gabriel T

2013-11-01

To evaluate medical students' behavior regarding online social networks (OSNs) in preparation for the residency matching process. The specific aims were to quantify the use of OSNs by students to determine whether and how these students were changing OSN profiles in preparation for the residency application process, and to determine attitudes toward residency directors using OSNs as a screening method to evaluate potential candidates. An e-mail survey was sent to 618 third- and fourth-year medical students at Indiana University School of Medicine over a three-week period in 2012. Statistical analysis was completed using nonparametric statistical tests. Of the 30.1% (183/608) who responded to the survey, 98.9% (181/183) of students reported using OSNs. More than half, or 60.1% (110/183), reported that they would (or did) alter their OSN profile before residency matching. Respondents' opinions regarding the appropriateness of OSN screening by residency directors were mixed; however, most respondents did not feel that their online OSN profiles should be used in the residency application process. The majority of respondents planned to (or did) alter their OSN profile in preparation for the residency match process. The majority believed that residency directors are screening OSN profiles during the matching process, although most did not believe their OSN profiles should be used in the residency application process. This study implies that the more medical students perceive that residency directors use social media in application screening processes, the more they will alter their online profiles to adapt to protect their professional persona.

Axial profiles of burned and fraction of holes for calculations of criticality with credit for BWR fuel burning

International Nuclear Information System (INIS)

Casado Sanchez, C.; Rubio Oviedo, P.

2014-01-01

This paper presents a method to define surround profiles of burning and fraction of holes suited for use in applications of credit to burning of BWR fuel from results obtained with the module STARBUCS of SCALE. (Author)

The cost - effective solar energy applications in Canada

International Nuclear Information System (INIS)

Pape, A.

1999-01-01

This paper outlines several cost-effective solar energy application in Canada, and estimates the GHG emission reduction potential for each. The applications include: (1) passive solar building design; (2) solar water heating applications; (3) solar photovoltaics for remote power; and (4) solar assisted space heating and cooling in industrial buildings. Each technology is briefly profiled in terms of functionality, cost characteristics, energy production characteristics and potential emission reduction benefits. Real-life examples of each application are also included. Finally, the paper concludes on the potential role of solar energy in the reduction of Canadian GHG emissions. (author)

EPICS-based control and data acquisition for the APS slope profiler (Conference Presentation)

Science.gov (United States)

Sullivan, Joseph; Assoufid, Lahsen; Qian, Jun; Jemian, Peter R.; Mooney, Tim; Rivers, Mark L.; Goetze, Kurt; Sluiter, Ronald L.; Lang, Keenan

2016-09-01

The motion control, data acquisition and analysis system for APS Slope Measuring Profiler was implemented using the Experimental Physics and Industrial Control System (EPICS). EPICS was designed as a framework with software tools and applications that provide a software infrastructure used in building distributed control systems to operate devices such as particle accelerators, large experiments and major telescopes. EPICS was chosen to implement the APS Slope Measuring Profiler because it is also applicable to single purpose systems. The control and data handling capability available in the EPICS framework provides the basic functionality needed for high precision X-ray mirror measurement. Those built in capabilities include hardware integration of high-performance motion control systems (3-axis gantry and tip-tilt stages), mirror measurement devices (autocollimator, laser spot camera) and temperature sensors. Scanning the mirror and taking measurements was accomplished with an EPICS feature (the sscan record) which synchronizes motor positioning with measurement triggers and data storage. Various mirror scanning modes were automatically configured using EPICS built-in scripting. EPICS tools also provide low-level image processing (areaDetector). Operation screens were created using EPICS-aware GUI screen development tools.

CZE/PAD and HPLC-UV/PAD Profile of Flavonoids from Maytenus aquifolium and Maytenus ilicifolia “espinheira santa” Leaves Extracts

OpenAIRE

Diagone, Cristina A.; Colombo, Renata; Lanças, Fernando M.; Yariwake, Janete H.

2012-01-01

This paper describes the application of HPLC and CZE to analyze flavonoids in the leaves of Maytenus ilicifolia and Maytenus aquifolium, which are species widely used in Brazilian folk medicine. The two species showed different flavonoid profiles, but acidic hydrolysis of the Maytenus extracts confirmed that all these compounds are quercetin or kaempferol derivatives. A comparison of the CZE and HPLC profiles of Maytenus extracts showed numerous flavonoid peaks using HPLC. However, the advant...

Discrepancies between multicriteria decision analysis-based ranking and intuitive ranking for pharmaceutical benefit-risk profiles in a hypothetical setting.

Science.gov (United States)

Hoshikawa, K; Ono, S

2017-02-01

Multicriteria decision analysis (MCDA) has been generally considered a promising decision-making methodology for the assessment of drug benefit-risk profiles. There have been many discussions in both public and private sectors on its feasibility and applicability, but it has not been employed in official decision-makings. For the purpose of examining to what extent MCDA would reflect the first-hand, intuitive preference of evaluators in practical pharmaceutical assessments, we conducted a questionnaire survey involving the participation of employees of pharmaceutical companies. Showing profiles of the efficacy and safety of four hypothetical drugs, each respondent was asked to rank them following the standard MCDA process and then to rank them intuitively (i.e. without applying any analytical framework). These two approaches resulted in substantially different ranking patterns from the same individuals, and the concordance rate was surprisingly low (17%). Although many respondents intuitively showed a preference for mild, balanced risk-benefit profiles over profiles with a conspicuous advantage in either risk or benefit, the ranking orders based on MCDA scores did not reflect the intuitive preference. Observed discrepancies between the rankings seemed to be primarily attributed to the structural characteristics of MCDA, which assumes that evaluation on each benefit and risk component should have monotonic impact on final scores. It would be difficult for MCDA to reflect commonly observed non-monotonic preferences for risk and benefit profiles. Possible drawbacks of MCDA should be further investigated prior to the real-world application of its benefit-risk assessment. © 2016 John Wiley & Sons Ltd.

High resolution humidity, temperature and aerosol profiling with MeteoSwiss Raman lidar

Science.gov (United States)

Dinoev, Todor; Arshinov, Yuri; Bobrovnikov, Sergei; Serikov, Ilya; Calpini, Bertrand; van den Bergh, Hubert; Parlange, Marc B.; Simeonov, Valentin

2010-05-01

Meteorological services rely, in part, on numerical weather prediction (NWP). Twice a day radiosonde observations of water vapor provide the required data for assimilation but this time resolution is insufficient to resolve certain meteorological phenomena. High time resolution temperature profiles from microwave radiometers are available as well but have rather low vertical resolution. The Raman LIDARs are able to provide temperature and humidity profiles with high time and range resolution, suitable for NWP model assimilation and validation. They are as well indispensible tools for continuous aerosol profiling for high resolution atmospheric boundary layer studies. To improve the database available for direct meteorological applications the Swiss meteo-service (MeteoSwiss), the Swiss Federal Institute of Technology in Lausanne (EPFL) and the Swiss National Science Foundation (SNSF) initiated a project to design and build an automated Raman lidar for day and night vertical profiling of tropospheric water vapor with the possibility to further upgrade it with an aerosol and temperature channels. The project was initiated in 2004 and RALMO (Raman Lidar for meteorological observations) was inaugurated in August 2008 at MeteoSwiss aerological station at Payerne. RALMO is currently operational and continuously profiles water vapor mixing ratio, aerosol backscatter ratio and aerosol extinction. The instrument is a fully automated, self-contained, eye-safe Raman lidar operated at 355 nm. Narrow field-of-view multi-telescope receiver and narrow band detection allow day and night-time vertical profiling of the atmospheric humidity. The rotational-vibrational Raman lidar responses from water vapor and nitrogen are spectrally separated by a high-throughput fiber coupled diffraction grating polychromator. The elastic backscatter and pure-rotational Raman lidar responses (PRR) from oxygen and nitrogen are spectrally isolated by a double grating polychromator and are used to

The quick convolution of galaxy profiles, with application to power-law intensity distributions

International Nuclear Information System (INIS)

Bailey, M.E.; Sparks, W.B.

1983-01-01

The two-dimensional convolution of a circularly symmetric galaxy model with a Gaussian point-spread function of dispersion σ reduces to a single integral. This is solved analytically for models with power-law intensity distributions and results are given which relate the apparent core radius to σ and the power-law index k. The convolution integral is also simplified for the case of a point-spread function corresponding to a circular aperture. Models of galactic nuclei with stellar density cusps can only be distinguished from alternatives with small core radii if both the brightness and seeing profiles are measured accurately. The results are applied to data on the light distribution at the Galactic Centre. (author)

The application of low angle Rutherford backscattering and channelling techniques to determine implantation induced disorder profile distributions in semiconductors

International Nuclear Information System (INIS)

Ahmed, N.A.G.; Christodoulides, C.E.; Carter, G.; Nobes, M.J.; Titov, A.I.

1980-01-01

Low angle exit (9 0 ) Rutherford backscattering geometry and channelling of 2 MeV 4 He + are employed to investigate the disorder depth profiles created by 40 keV N + implantation in (111) silicon and (100) GaAs targets. Parameters which can influence the disordering rate and its spatial distribution, such as ion fluence flux, substrate type and substrate temperature are examined. Under certain implantation conditions, the damage profile distributions are asymmetric - exhibiting a bimodal form in silicon targets or confined much closer to the GaAs surface than the normally expected mean range of 40 keV N + ions. (orig.)

Real time n/γ discrimination for the JET neutron profile monitor

Energy Technology Data Exchange (ETDEWEB)

Riva, M., E-mail: marco.riva@enea.it [Associazione EURATOM-ENEA sulla Fusione, C.P. 65, Frascati I-00044, Roma (Italy); Esposito, B.; Marocco, D.; Belli, F. [Associazione EURATOM-ENEA sulla Fusione, C.P. 65, Frascati I-00044, Roma (Italy); Syme, B. [EURATOM/CCFE Fusion Association, OX14 3DB Abingdon (United Kingdom); Giacomelli, L. [Dipartimento di Fisica, Università degli Studi di Milano-Bicocca (Italy); Istituto di Fisica del Plasma, Associazione EURATOM-ENEA-CNR, 20100 Milano (Italy); JET-EFDA, Culham Science Centre, OX14 3DB Abingdon (United Kingdom)

2013-10-15

Highlights: ► Development of a pulse oriented acquisition system able for the JET neutron profile monitor to separate neutron and gamma pulses. ► Description of the FPGA hardware architecture. ► Comparison between the off-line and real time neutron count rates from the last JET experimental campaign. ► Estimate of the maximum sustainable count rate of the system. ► Statistical analysis of neutron measurements from JET neutron profile monitor and neutron monitors. -- Abstract: The JET neutron profile monitor provides the measurement of the neutron flux along 19 collimated lines of sight from which the neutron emissivity profile can be obtained through reconstruction based on inversion methods. The neutron detectors are liquid organic scintillators featuring n/γ pulse shape discrimination. A recent digital upgrade of the neutron profile monitor acquisition system (200 MSamples/s sampling rate per channel, 14 bit resolution) offers new real-time capabilities. An algorithm performing real-time n/γ discrimination by means of the charge comparison method is implemented in the acquisition system FPGA. The algorithm produces two distinct count rates (n and γ) that are sent to the JET real time network ready for control applications and are simultaneously stored into the JET archive together with all the samples of each pulse. The paper describes the architecture of the FPGA implementation and reports the analysis of data collected during the 2011–2012 JET campaigns. The comparison between the real-time and post-processed (off-line) neutron count rates shows an agreement within 5% for all 19 detectors. Moreover, it is shown that the maximum count rate sustainable by the acquisition system when storing raw data (∼900 kHz as evaluated in laboratory tests) can be extended up to 5 MHz when using the real-time implementation with no local data storage. Finally, a statistical analysis of the ratio between the line-integrated measurements from the neutron profile

Measurement of multi-slice computed tomography dose profile with the Dose Magnifying Glass and the MOSkin radiation dosimeter

International Nuclear Information System (INIS)

Lian, C.P.L.; Wong, J.H.D.; Young, A.; Cutajar, D.; Petasecca, M.; Lerch, M.L.F.; Rosenfeld, A.B.

2013-01-01

This study describes the application of two in-house developed dosimeters, the Dose Magnifying Glass (DMG) and the MOSkin dosimeter at the Centre for Medical Radiation Physics, University of Wollongong, Australia, for the measurement of CT dose profiles for a clinical diagnostic 16-slice MSCT scanner. Two scanner modes were used; axial mode and helical mode, and the effect of varying beam collimation and pitch was studied. With an increase in beam collimation in axial mode and an increase of CT pitch in helical mode, cumulative point dose at scanner isocentre decreased while FWHM increased. There was generally good agreement to within 3% between the acquired dose profiles obtained by the DMG and the film except at dose profile tails, where film over-responded by up to 30% due to its intrinsic depth dose dependence at low doses. -- Highlights: ► This study shows the CT beam profiles acquired with our institution's detectors. ► The DMG is a relative dosimeter calibrated to absolute MOSkin readings. ► There was good agreement between dose profiles acquired by the DMG and the film

A predictable Java profile

DEFF Research Database (Denmark)

Bøgholm, Thomas; Hansen, Rene Rydhof; Ravn, Anders Peter

2009-01-01

A Java profile suitable for development of high integrity embedded systems is presented. It is based on event handlers which are grouped in missions and equipped with respectively private handler memory and shared mission memory. This is a result of our previous work on developing a Java profile......, and is directly inspired by interactions with the Open Group on their on-going work on a safety critical Java profile (JSR-302). The main contribution is an arrangement of the class hierarchy such that the proposal is a generalization of Real-Time Specification for Java (RTSJ). A further contribution...

Detonation Wave Profile

Energy Technology Data Exchange (ETDEWEB)

Menikoff, Ralph [Los Alamos National Laboratory

2015-12-14

The Zel’dovich-von Neumann-Doering (ZND) profile of a detonation wave is derived. Two basic assumptions are required: i. An equation of state (EOS) for a partly burned explosive; P(V, e, λ). ii. A burn rate for the reaction progress variable; d/dt λ = R(V, e, λ). For a steady planar detonation wave the reactive flow PDEs can be reduced to ODEs. The detonation wave profile can be determined from an ODE plus algebraic equations for points on the partly burned detonation loci with a specified wave speed. Furthermore, for the CJ detonation speed the end of the reaction zone is sonic. A solution to the reactive flow equations can be constructed with a rarefaction wave following the detonation wave profile. This corresponds to an underdriven detonation wave, and the rarefaction is know as a Taylor wave.

Qualitative Value Profiling

DEFF Research Database (Denmark)

Duus, Henrik Johannsen; Bjerre, Mogens

2015-01-01

allows the development of 1) profiles of the target country in which operations are to take place, 2) profiles of the buying center (i.e. the group of decision makers) in the partner company, and 3) profiles of the product/service offering. It also allows the development of a semantic scaling method...... for deeper analysis of all involved factors. This paper presents the method and compares and contrasts it with other similar methods like the PESTELE method known from corporate strategy, the STEEPAL method known from scenario analysis, and the Politics-Institutions-Economy (PIE) framework known from...... International Business. This comparison suggests that QVP on most accounts provides deeper insights than alternative methods and thus lays the foundation for better strategic planning in international business-to-business markets. Hence, it is a valuable addition to the toolbox of business strategists...

Exploiting the full power of temporal gene expression profiling through a new statistical test: Application to the analysis of muscular dystrophy data

Directory of Open Access Journals (Sweden)

Turk Rolf

2006-04-01

Full Text Available Abstract Background The identification of biologically interesting genes in a temporal expression profiling dataset is challenging and complicated by high levels of experimental noise. Most statistical methods used in the literature do not fully exploit the temporal ordering in the dataset and are not suited to the case where temporal profiles are measured for a number of different biological conditions. We present a statistical test that makes explicit use of the temporal order in the data by fitting polynomial functions to the temporal profile of each gene and for each biological condition. A Hotelling T2-statistic is derived to detect the genes for which the parameters of these polynomials are significantly different from each other. Results We validate the temporal Hotelling T2-test on muscular gene expression data from four mouse strains which were profiled at different ages: dystrophin-, beta-sarcoglycan and gamma-sarcoglycan deficient mice, and wild-type mice. The first three are animal models for different muscular dystrophies. Extensive biological validation shows that the method is capable of finding genes with temporal profiles significantly different across the four strains, as well as identifying potential biomarkers for each form of the disease. The added value of the temporal test compared to an identical test which does not make use of temporal ordering is demonstrated via a simulation study, and through confirmation of the expression profiles from selected genes by quantitative PCR experiments. The proposed method maximises the detection of the biologically interesting genes, whilst minimising false detections. Conclusion The temporal Hotelling T2-test is capable of finding relatively small and robust sets of genes that display different temporal profiles between the conditions of interest. The test is simple, it can be used on gene expression data generated from any experimental design and for any number of conditions, and it

A New Profile Shape Matching Stereovision Algorithm for Real-time Human Pose and Hand Gesture Recognition

Directory of Open Access Journals (Sweden)

Dong Zhang

2014-02-01

Full Text Available This paper presents a new profile shape matching stereovision algorithm that is designed to extract 3D information in real time. This algorithm obtains 3D information by matching profile intensity shapes of each corresponding row of the stereo image pair. It detects the corresponding matching patterns of the intensity profile rather than the intensity values of individual pixels or pixels in a small neighbourhood. This approach reduces the effect of the intensity and colour variations caused by lighting differences. As with all real-time vision algorithms, there is always a trade-off between accuracy and processing speed. This algorithm achieves a balance between the two to produce accurate results for real-time applications. To demonstrate its performance, the proposed algorithm is tested for human pose and hand gesture recognition to control a smart phone and an entertainment system.

Laquinimod Safety Profile

DEFF Research Database (Denmark)

Sørensen, Per Soelberg; Comi, Giancarlo; Vollmer, Timothy L

2017-01-01

the safety profile of laquinimod versus placebo. Adverse events (AEs), laboratory value changes, and potential risks identified in preclinical studies were evaluated in participants in ALLEGRO and BRAVO treated with at least one dose of laquinimod or matching placebo (1:1 random assignment). RESULTS...... laquinimod studies demonstrate a safety profile comprising benign or manageable AEs and asymptomatic laboratory findings with a clear temporal pattern. Potential risks noted in preclinical studies were not observed....

Creating Evaluation Profiles for Games Designed to be Fun: An Interpretive Framework for Serious Game Mechanics

DEFF Research Database (Denmark)

Ulrich, Frank; Helms, Niels Henrik

2017-01-01

an interpretive evaluation framework that can identify the educational value in COTS games. Application. The presented framework can create evaluative profiles of the learning, social, game, and immersive mechanics of COTS games as educational tools. Moreover, the framework can position COTS games between four...... intertwined dimensions, namely pedagogical, design, knowledge, and sociotechnical considerations. Demonstration. To validate the practical application of the interpretive framework, we apply it to a real-world example. Our demonstration reveals the usefulness of the framework. Conclusions. The framework...

Profile Changes in the Soil Microbial Community When Desert Becomes Oasis.

Directory of Open Access Journals (Sweden)

Chen-hua Li

Full Text Available The conversion of virgin desert into oasis farmland creates two contrasting types of land-cover. During oasis formation with irrigation and fertilizer application, however, the changes in the soil microbial population, which play critical roles in the ecosystem, remain poorly understood. We applied high-throughput pyrosequencing to investigate bacterial and archaeal communities throughout the profile (0-3 m in an experimental field, where irrigation and fertilization began in 1990 and cropped with winter wheat since then. To assess the effects of cultivation, the following treatments were compared with the virgin desert: CK (no fertilizer, PK, NK, NP, NPK, NPKR, and NPKM (R: straw residue; M: manure fertilizer. Irrigation had a greater impact on the overall microbial community than fertilizer application. The greatest impact occurred in topsoil (0-0.2 m, e.g., Cyanobacteria (25% total abundance were most abundant in desert soil, while Actinobacteria (26% were most abundant in oasis soil. The proportions of extremophilic and photosynthetic groups (e.g., Deinococcus-Thermus and Cyanobacteria decreased, while the proportions of R-strategy (e.g., Gammaproteobacteria including Xanthomonadales, nitrifying (e.g., Nitrospirae, and anaerobic bacteria (e.g., Anaerolineae increased throughout the oasis profile. Archaea occurred only in oasis soil. The impact of fertilizer application was mainly reflected in the non-dominant communities or finer taxonomic divisions. Oasis formation led to a dramatic shift in microbial community and enhanced soil enzyme activities. The rapidly increased soil moisture and decreased salt caused by irrigation were responsible for this shift. Furthermore, difference in fertilization and crop growth altered the organic carbon contents in the soil, which resulted in differences of microbial communities within oasis.

Analysis of Phenolic and Cyclic Compounds in Plants Using Derivatization Techniques in Combination with GC-MS-Based Metabolite Profiling

Directory of Open Access Journals (Sweden)

Jens Rohloff

2015-02-01

Full Text Available Metabolite profiling has been established as a modern technology platform for the description of complex chemical matrices and compound identification in biological samples. Gas chromatography coupled with mass spectrometry (GC-MS in particular is a fast and accurate method widely applied in diagnostics, functional genomics and for screening purposes. Following solvent extraction and derivatization, hundreds of metabolites from different chemical groups can be characterized in one analytical run. Besides sugars, acids, and polyols, diverse phenolic and other cyclic metabolites can be efficiently detected by metabolite profiling. The review describes own results from plant research to exemplify the applicability of GC-MS profiling and concurrent detection and identification of phenolics and other cyclic structures.

A reliability index for assessment of crack profile reconstructed from ECT signals using a neural-network approach

International Nuclear Information System (INIS)

Yusa, Noritaka; Chen, Zhenmao; Miya, Kenzo; Cheng, Weiying

2002-01-01

This paper proposes a reliability parameter to enhance an version scheme developed by authors. The scheme is based upon an artificial neural network that simulates mapping between eddy current signals and crack profiles. One of the biggest advantages of the scheme is that it can deal with conductive cracks, which is necessary to reconstruct natural cracks. However, it has one significant disadvantage: the reliability of reconstructed profiles was unknown. The parameter provides an index for assessment of the crack profile and overcomes this disadvantage. After the parameter is validated by reconstruction of simulated cracks, it is applied to reconstruction of natural cracks that occurred in steam generator tubes of a pressurized water reactor. It is revealed that the parameter is applicable to not only simulated cracks but also natural ones. (author)

Use of glow discharge in measurement of diffusion profile

International Nuclear Information System (INIS)

Baudin, Guy

1976-05-01

The composition of a glow discharge plasma is a good image of the composition of the surface being erroded without fusion. The depth of metal eated away is a linear function of time in 10 to 60μ range, that is too say between 2 and 20 minutes after lightning of the lamp. So measuring the emission of the discharge is function of time gives the diffusion profile of elements either by measuring instantaneous signal or by integrating during short periods of time for weak concentration. Examples of application for diffusion of N 2 and C in steel will be given [fr

Chemical-mineralogical study of the ferrosialitic lateritic profiles in the Teneme, Farallones and Cayo Guam sectors in north east Cuba

International Nuclear Information System (INIS)

Njila, Tendai; Diaz Martinez, Roberto

2016-01-01

The results of a chemical-mineralogical study on the ferrosialitic lateritic weathering profile are presented. Analysis was done using x Ray Fluorescence and Diffraction. The chemical composition of these profile reflects a typical pattern normally observed within such weathering crusts. The sesquioxides of aluminium, iron are concentrated in the upper parts of the profiles as a result of the leaching of alkalis, alkaline-earth elements, and to a lesser extent, silica. Ferrosialitic lateritic profiles formed on Cretaceous and Paleogene islands arcs consist of secondary minerals such as gibbsite, kaolinite, goethite, hematite and montmorillonite, while those associated with basic and volcanogenic-sedimentary rocks of ophiolitic affinity in Cayo Guam are composed of gibbsite and iron oxides. Brings new chemical-mineralogical information on the ferrosialitic lateritic profiles associated with rocks of oceanic nature in north-eastern Cuba, which will help in the exploration for industrial minerals and rocks and their application in industry. (author) [es

Institutional Profiles: Some Strategic Tools

Directory of Open Access Journals (Sweden)

Frans van Vught

2014-04-01

Full Text Available In this paper we argue that both internal and external pressures and conditions urge contemporary higher education institutions to carefully think through their institutional profiles positions in domestic and global higher education contexts. We subsequently analyse strategic positioning from the strategic management literature and offer four tools — mapping, multi-dimensional ranking, benchmarking and degree profiling — to assist higher education institutions in their profiling and positioning strategies.

Tomographic reconstruction of transverse phase space from turn-by-turn profile data

CERN Document Server

Hancock, S; Lindroos, M

1999-01-01

Tomographic methods have the potential for useful application in beam diagnostics. The tomographic reconstruction of transverse phase space density from turn-by-turn profile data has been studied with particular attention to the effects of dispersion and chromaticity. It is shown that the modified Algebraic Reconstruction Technique (ART) that deals successfully with the problem of non-linear motion in the longitudinal plane cannot, in general, be extended to cover the transverse case. Instead, an approach is proposed in which the effect of dispersion is deconvoluted from the measured profiles before the phase space picture is reconstructed using either the modified ART algorithm or the inverse Radon Transform. This requires an accurate knowledge of the momentum distribution of the beam and the modified ART reconstruction of longitudinal phase space density yields just such information. The method has been tested extensively with simulated data.

An online, energy-resolving beam profile detector for laser-driven proton beams

Energy Technology Data Exchange (ETDEWEB)

Metzkes, J.; Rehwald, M.; Obst, L.; Schramm, U. [Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Bautzner Landstr. 400, 01328 Dresden (Germany); Technische Universität Dresden, 01062 Dresden (Germany); Zeil, K.; Kraft, S. D.; Sobiella, M.; Schlenvoigt, H.-P. [Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Bautzner Landstr. 400, 01328 Dresden (Germany); Karsch, L. [OncoRay-National Center for Radiation Research in Oncology, Technische Universität Dresden, 01307 Dresden (Germany)

2016-08-15

In this paper, a scintillator-based online beam profile detector for the characterization of laser-driven proton beams is presented. Using a pixelated matrix with varying absorber thicknesses, the proton beam is spatially resolved in two dimensions and simultaneously energy-resolved. A thin plastic scintillator placed behind the absorber and read out by a CCD camera is used as the active detector material. The spatial detector resolution reaches down to ∼4 mm and the detector can resolve proton beam profiles for up to 9 proton threshold energies. With these detector design parameters, the spatial characteristics of the proton distribution and its cut-off energy can be analyzed online and on-shot under vacuum conditions. The paper discusses the detector design, its characterization and calibration at a conventional proton source, as well as the first detector application at a laser-driven proton source.

SU-E-T-459: Impact of Source Position and Traveling Time On HDR Skin Surface Applicator Dosimetry

International Nuclear Information System (INIS)

Jeong, J; Barker, C; Zaider, M; Cohen, G

2015-01-01

Purpose: Observed dosimetric discrepancy between measured and treatment planning system (TPS) predicted values, during applicator commissioning, were traced to source position uncertainty in the applicator. We quantify the dosimetric impact of this geometric uncertainty, and of the source traveling time inside the applicator, and propose corrections for clinical use. Methods: We measured the dose profiles from the Varian Leipzig-style (horizontal) HDR skin applicator, using EBT3 film, photon diode, and optically stimulated luminescence dosimeter (OSLD) and three different GammaMed HDR afterloders. The dose profiles and depth dose of each aperture were measured at several depths (up to about 10 mm, depending on the dosimeter). The measured dose profiles were compared with Acuros calculated profiles in BrachyVision TPS. For the impact of the source position, EBT3 film measurements were performed with applicator, facing-down and facing-up orientations. The dose with and without source traveling was measured with diode detector using HDR timer and electrometer timer, respectively. Results: Depth doses measured using the three dosimeters were in good agreement, but were consistently higher than the Acuros dose calculations. Measurements with the applicator facing-up were significantly lower than those in the facing-down position with maximum difference of about 18% at the surface, due to source sag inside the applicator. Based on the inverse-square law, the effective source sag was evaluated to be about 0.5 mm from the planned position. The additional dose from the source traveling was about 2.8% for 30 seconds with 10 Ci source, decreasing with increased dwelling time and decreased source activity. Conclusion: Due to the short source-to-surface distance of the applicator, the small source sag inside the applicator has significant dosimetric impact, which should be considered before the clinical use of the applicator. Investigation of the effect for other applicators

Profile catalogue for airfoil sections based on 3D computations

DEFF Research Database (Denmark)

Bertagnolio, F.; Sørensen, Niels N.; Johansen, Jeppe

2006-01-01

This report is a continuation of the Wind Turbine Airfoil Catalogue [1] which objective was, firstly to provide a database of aerodynamic characteristics for a wide range of airfoil profiles aimed at wind turbine applications, and secondly to test thetwo-dimensional Navier-Stokes solver EllipSys2D...... and the actual fluid flow, and thereby the incorrect prediction of airfoil characteristics. In addition, other features of the flow solver, such astransition and turbulence modelling, and their influence onto the numerical results are investigated. Conclusions are drawn regarding the evaluation of airfoil...

Country profile: Hungary

Energy Technology Data Exchange (ETDEWEB)

1991-09-01

Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary`s energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

Country profile: Hungary

Energy Technology Data Exchange (ETDEWEB)

1991-09-01

Country Profile: Hungary has been prepared as a background document for use by US Government agencies and US businesses interested in becoming involved with the new democracies of Eastern Europe as they pursue sustainable economic development. The focus of the Profile is on energy and highlights information on Hungary's energy supply, demand, and utilization. It identifies patterns of energy usage in the important economic sectors, especially industry, and provides a preliminary assessment for opportunities to improve efficiencies in energy production, distribution and use by introducing more efficient technologies. The use of more efficient technologies would have the added benefit of reducing the environmental impact which, although is not the focus of the report, is an issue that effects energy choices. The Profile also presents considerable economic information, primarily in the context of how economic restructuring may affect energy supply, demand, and the introduction of more efficient technologies.

The Use of New Technologies in Basic Education: An Approach to Profile of Indigenous Ecuadorians

Science.gov (United States)

Stefos, Efstathios; Castellano, José Manuel; Marchán, Andrés Bonilla; Biloon, Julia Raina Sevy

2017-01-01

This article aims to define the profile of Ecuadorian indigenous students who study at different levels of basic education in Ecuador in the context of the application and use of emerging technologies in the last five years. This approach focuses on a comparative analysis between indigenous and non-indigenous students, based on the national data…

Identification of intestinal loss of a drug through physiologically based pharmacokinetic simulation of plasma concentration-time profiles.

Science.gov (United States)

Peters, Sheila Annie

2008-01-01

Despite recent advances in understanding of the role of the gut as a metabolizing organ, recognition of gut wall metabolism and/or other factors contributing to intestinal loss of a compound has been a challenging task due to the lack of well characterized methods to distinguish it from first-pass hepatic extraction. The implications of identifying intestinal loss of a compound in drug discovery and development can be enormous. Physiologically based pharmacokinetic (PBPK) simulations of pharmacokinetic profiles provide a simple, reliable and cost-effective way to understand the mechanisms underlying pharmacokinetic processes. The purpose of this article is to demonstrate the application of PBPK simulations in bringing to light intestinal loss of orally administered drugs, using two example compounds: verapamil and an in-house compound that is no longer in development (referred to as compound A in this article). A generic PBPK model, built in-house using MATLAB software and incorporating absorption, metabolism, distribution, biliary and renal elimination models, was employed for simulation of concentration-time profiles. Modulation of intrinsic hepatic clearance and tissue distribution parameters in the generic PBPK model was done to achieve a good fit to the observed intravenous pharmacokinetic profiles of the compounds studied. These optimized clearance and distribution parameters are expected to be invariant across different routes of administration, as long as the kinetics are linear, and were therefore employed to simulate the oral profiles of the compounds. For compounds with reasonably good solubility and permeability, an area under the concentration-time curve for the simulated oral profile that far exceeded the observed would indicate some kind of loss in the intestine. PBPK simulations applied to compound A showed substantial loss of the compound in the gastrointestinal tract in humans but not in rats. This accounted for the lower bioavailability of the

User profiling and classification for fraud detection in mobile communications networks

OpenAIRE

Hollmén, Jaakko

2000-01-01

The topic of this thesis is fraud detection in mobile communications networks by means of user profiling and classification techniques. The goal is to first identify relevant user groups based on call data and then to assign a user to a relevant group. Fraud may be defined as a dishonest or illegal use of services, with the intention to avoid service charges. Fraud detection is an important application, since network operators lose a relevant portion of their revenue to fraud. Whereas the int...

Perception, understanding and initiatives with regard to sustainable development: A profile of Québec tourism organizations

OpenAIRE

Auger, Denis; Bélanger, Vincent

2011-01-01

The concept of sustainable development is not new. However, its application in the field of tourism in Québec needs to be clarified. This way, this study is aimed at drawing the profile of Québec tourist organizations, at comparing the initiatives developed according to various perspectives (environmental, social and economic) and finally, to verify the coherence between the level of importance these organizations give to the concepts of sustainable development and the application of these wi...

Urban logistics profile – Yogyakarta city, Indonesia

Directory of Open Access Journals (Sweden)

Maria Sri Asih Anna

2018-01-01

Full Text Available In recent years, more rural areas are becoming urban areas accompanied by escalation of logistics activities. Unlike passenger transport, the planning, policy and control of freight transport in developing countries have not been integrated into a reliable and efficient logistics system. Therefore, generating city logistics profile is necessary in order to support the planning of urban logistics system. This study aims to establish a logistics profile of Yogyakarta city, Indonesia, by dividing urban zones into several homogeneous groups, judging from several aspects, including city area features, product characteristics and agents/delivery profile. Logistics profile variables were calculated based on administrative boundaries, resulting in 45 areas to be investigated. Profiles were matched in groups of homogeneous stores (A, large commercial stores (C and residential areas with local trade (D,with one overlapping profile, i.e. profile A and profile D, in some locations in the middle of the city.

On Active Current Selection for Lagrangian Profilers

Directory of Open Access Journals (Sweden)

J. Jouffroy

2013-01-01

Full Text Available Autonomous Lagrangian profilers are now widely used as measurement and monitoring platforms, notably in observation programs as Argo. In a typical mode of operation, the profilers drift passively at their parking depthbefore making a vertical profile to go back to the surface. This paperpresents simple and computationally-efficient control strategies to activelyselect and use ocean currents so that a profiler can autonomously reach adesired destination. After briefly presenting a typical profiler andpossible mechanical modifications for a coastal environment, we introducesimple mathematical models for the profiler and the currents it will use. Wethen present simple feedback controllers that, using the direction of thecurrents and taking into account the configuration of the environment(coastal or deep-sea, is able to steer the profiler to any desiredhorizontal location. To illustrate the approach, a few results are presentedusing both simulated currents and real current velocity profiles from theNorth Sea.