WorldWideScience

Sample records for favourability studies brunei

  1. Child Rearing Study in Brunei Darussalam.

    Science.gov (United States)

    Rosberg, Marilee A.

    In order to gather data on children's lives, language, and religious activities, and to gather data on child rearing practices in Brunei, a study interviewed parents from 38 Malaysian families having one or more children 3-8 years old. Results indicated that 92 percent of the children crawled when they were between 6-9 months old; 63 percent were…

  2. A preliminary study of dengue infection in Brunei.

    Science.gov (United States)

    Osman, Osmali; Fong, Mun Yik; Devi, Shamala

    2007-07-01

    The purpose of this study was to examine the extent of dengue infection in Brunei and to determine the predominant serotype circulating in the country. The study generated useful epidemiological data on dengue infection in Brunei. A total of 271 samples from patients suspected of having dengue infections were selected and analyzed. All patients were seen in clinics and hospitals in Brunei. The samples were collected from April 2005 to April 2006 and transported to the WHO Collaborating Centre for Arbovirus Reference and Research, University of Malaya, Malaysia. The following tests were used to achieve the objectives: in-house IgM-capture enzyme-linked immunosorbent assay, virus isolation in mosquito albopictus cell line (C6/36), and viral RNA detection and serotyping by reverse transcriptase-polymerase chain reaction (RT-PCR). The results show that 45 people were positive for dengue-specific IgM (27 males and 18 females), while RT-PCR detected dengue viral RNA in 12 patients, 3 identified as DEN-1 and 9 as DEN-2. Dengue virus was isolated from 6 patients using the C6/36 cell line; 3 were DEN-2 isolates and 3 were DEN-1 isolates. These data show that dengue virus is circulating in Brunei and the predominant infecting serotype for that period was DEN-2 followed by DEN-1. This study is the first to report the detection and isolation of dengue virus from Brunei using RT-PCR and culture in the C6/36 albopictus mosquito cell line.

  3. Village midwives and their changing roles in Brunei Darussalam: A qualitative study.

    Science.gov (United States)

    Abdul-Mumin, Khadizah Haji

    2016-10-01

    There are lay midwives worldwide, interchangeably and universally called traditional birth attendants or traditional midwives by organisations such as the World Health Organization and the International Confederation of Midwives. This study aimed to explore the history of lay midwives (village midwives) in Brunei, describe the evolution from their previous to current roles and determine if they are still needed by women today. This qualitative, descriptive study included in-depth, semi-structured interviews with eight women who had received care from village midwives. Data analysis was based on the principles underpinning thematic analysis and used a constant comparative method. Village midwives have been popular in Brunei since the 1900s, with their major role being to assist women with childbirth. However, since the 1960s, their roles and practices have changed to focus on pre-conception, antenatal, postnatal and women's general healthcare. Traditional practices were influenced by religion, culture and the social context of and within Brunei. The major changes in village midwives' roles and practices resulted from the enforcement of the Brunei Midwives' Act in 1956. Village midwives' traditional practices became juxtaposed with modern complementary alternative medicine practices, and they began charging a fee for their services. Brunei village midwives are trusted by women, and their practices may still be widely accepted in Brunei. Further research is necessary to confirm their existence, determine the detailed scope and appropriateness of their practices and verify the feasibility of them working together with healthcare professionals. Copyright © 2016 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

  4. Brunei Darussalam.

    Science.gov (United States)

    1985-04-01

    Brunei's population characteristics, geographical features, history, form of government, and political and economic situation were briefly described. Brunei is a small country on the northwest coast of the island of Borneo. Estimated population size is 214,000 (1983), and the annual population growth rate is 0.35% (1971-81). Ethnically, the population is 65% Malay, 20% Chinese, and 15% other. The major religion is Islam, and a variety of languages are spoken, including Malay, English, Chinese, and Iban. Education is compulsory through the primary grades, and the literacy rate among the young is 95%. Between the 1500s and the 1800s, the country was a Buddhist kingdom, then a Hindu kingdom, and finally an Islamic kingdom. In 1847 the Sultan of Brunei entered into a trade agreement with Great Britain, and in 1888 the country was placed under British rule. In 1929 the discovery of oil lead to the economic development of the country. During World War II, the country was occupied by the Japanese. In 1984, after resisting pressure to unite with Sarawak and Malaysia, Brunei was granted independence. At that time it adopted the official name of Brunei Darussalam. The country remains a hereditary sultanate, and the current sultan is Sir Muda Hassanal Bolkaih Mu'izzaddin Waddaulah. The sultan has supreme executive authority and is assisted in administering the country by a 6-person cabinet which includes 3 members of the royal family. 46% of the work force is employed by the government, and government workers are provided with an extensive array of economic benefits, ranging from free medical care to low interest loans. The economy is based primarily on the production of oil and gas, which is produced by Brunei Shell, a consortium owned jointly by the government and Shell Oil. Brunei Shell is the country's 2nd largest employer next to the government, accounts for 72% of the gross domestic product (GDP), and is the primary source of government revenue. Oil accounts for 99% of

  5. Foreign Language Learners' Motivation and Its Effects on Their Achievement: Implications for Effective Teaching of Students Studying Japanese at Universiti Brunei Darussalam

    Science.gov (United States)

    Keaney, Minako; Mundia, Lawrence

    2014-01-01

    An increasing number of students at the University of Brunei Darussalam are studying the Japanese language. However, research on the relationship between learners' motivation and their achievement has not been given sufficient attention in Japanese foreign language education compared to English in Brunei. The present study, which utilized a…

  6. Service Quality in Higher Education--A Case Study of Universiti Brunei Darussalam

    Science.gov (United States)

    Alani, Farooq; Yaqoub, Yasir; Hamdan, Mahani

    2015-01-01

    No one doubts the value and importance of quality education, and quality assurance is one major driving force to achieve this. Measuring the performance of service quality of education services of Universiti Brunei Darussalam (UBD), as part of the quality assessment, was assessed based on Parasuraman's five Servqual dimensions. The assessment was…

  7. Enterovirus 71 Outbreak, Brunei

    OpenAIRE

    AbuBakar, Sazaly; Sam, I-Ching; Yusof, Jaliha; Lim, Meng Keang; Misbah, Suzana; ,; Hooi, Poh-Sim

    2009-01-01

    Enterovirus 71 (EV71) outbreaks occur periodically in the Asia-Pacific region. In 2006, Brunei reported its first major outbreak of EV71 infections, associated with fatalities from neurologic complications. Isolated EV71 strains formed a distinct lineage with low diversity within subgenogroup B5, suggesting recent introduction and rapid spread within Brunei.

  8. A Comparison of Learning Styles and Study Strategies Used by Low and High Math Achieving Brunei Secondary School Students: Implications for Teaching

    Science.gov (United States)

    Shahrill, Masitah; Mahalle, Salwa; Matzin, Rohani; Hamid, Malai Hayati Sheikh; Mundia, Lawrence

    2013-01-01

    The survey assessed the learning styles and study strategies used by 135 randomly selected Brunei secondary school students and compared them by educational level, math ability, and gender. Junior students (Forms 1-3) rely heavily on the use of the written-expressive learning style than their senior counterparts (Forms 4-5). In addition, the more…

  9. Effect of the Jigsaw-Based Cooperative Learning Method on Student Performance in the General Certificate of Education Advanced-Level Psychology: An Exploratory Brunei Case Study

    Science.gov (United States)

    Azmin, Nur Hafizah

    2016-01-01

    The mixed-methods study investigated the effect of the jigsaw cooperative learning method on student performance in psychology and their views towards it. Experimental data were obtained via pre-and-post tests and an open-ended questionnaire from 16 conveniently selected students at one Sixth Form College in Brunei. Moreover, the participants…

  10. Brunei Darussalam; Statistical Appendix

    OpenAIRE

    International Monetary Fund

    2011-01-01

    The statistical appendices present the following details for Brunei Darussalam: Nominal GDP and quarterly nominal GDP by economic activity, nominal GDP and quarterly nominal GDP by expenditure, quarterly composition of nominal GDP and composition of nominal GDP by activity, real GDP and quarterly real GDP by economic activity and expenditure, oil and gas production and sales, consumer price index, imports and exports by commodities, country destination exchange rates, energy sector, financial...

  11. A Practical and Reflexive Liberal-Humanist Approach to International Mindedness in International Schools: Case Studies from Malaysia and Brunei

    Science.gov (United States)

    Tamatea, Laurence

    2008-01-01

    This article explores the response to cultural diversity and international mindedness at international schools in Malaysia and Brunei. It shows that the curriculum at these schools is set within a liberal-humanist framework, which some might suggest facilitates the project of "Westernization". It argues, however, that under the (local)…

  12. Genetic variation of 12 rice cultivars grown in Brunei Darussalam ...

    African Journals Online (AJOL)

    Dell

    2015-03-25

    Mar 25, 2015 ... Genetic variations of 12 different rice cultivars in Brunei Darussalam were studied using 15 different. SSR markers ..... Principles of plant breeding: John Wiley & Sons Inc.,. New York .... and reproductive development of rice.

  13. KANUNISASI FIKIH JINAYAT KONTEMPORER Studi Materi Muatan Qānūn Jināyat Aceh dan Brunei Darussalam

    Directory of Open Access Journals (Sweden)

    Samsudin Aziz

    2014-10-01

    Full Text Available This article will view specifically codification of Islamic Criminal Law in `Muslim community, such as Brunei Darussalam, a country based on Islamic principles, and Aceh is a part of Indonesian territory administratively, granted special autonomy to implement Islamic Sharia. Despite having different qualities, -as a country and a province- both have in common as a political power which apply Islamic Criminal Law. Refer to both qānūn jināyat in Brunei and Aceh, the author’ll explain the substance of the criminal law in both area, while also reinforces the implementation of Islamic Criminal Law in the framework of a modern state. The article concludes that basically the application of Islamic Sharia, particularly the Islamic Criminal Law, is closely related to the situation and socio-political conditions of a community or country. The differences of political system, for example, has contributed to the difference in the output of product or policy made by a particular country or territory. On the other hand, Brunei and the Aceh case show that there has been adjustment Islamic Criminal Law specifically set forth in the books of fiqh (as illustration of the Qur'an and Sunnah with the needs of the community itself

  14. Coastal resources of Brunei Darussalam: Status, utilization and management

    Energy Technology Data Exchange (ETDEWEB)

    Silvestre, G.; Jaafar, H.M.H.; Yusof, P.S.P.H.; De Silva, M.W.R.N.; Chua, T.E.

    1992-01-01

    In light of the environmental dangers accompanying its recent program of economic diversification, the Government of Brunei Darussalam has signalled the need for improved management of its coastal areas, where 85 percent of the population lives and the country's social and economic activities are concentrated. The report contains the proceedings of a conference held in 1991 to review recent studies of Brunei Darussalam's coastal resources and draft an initial coastal area management plan. Individual papers cover: capture fisheries; mangrove and mangrove forest resources; fish communities in natural reef and artificial habitats; coastal area water quality; the populations and diversity of benthic fauna that inhabit coastal waters and are threatened by oil spills; a simulation of oil slick movement in Brunei Darussalam; a composite sensitivity index ranking the susceptibility of Brunei's five zones (as identified by resource prevalence) to oil spills; a management strategy for Brunei's 33 islands, most of which are uninhabited; zoning of industrial activities to minimize adverse effects on coastal water quality and the environment; the socioeconomic importance of Brunei's coastal resources; and the legal and institutional environment for coastal resource management.

  15. Re-Engineering Values into the Youth Education System: A Needs Analysis Study in Brunei Darussalam

    Science.gov (United States)

    Zakaria, Gamal Abdul Nasir; Tajudeen, Ahmad Labeeb; Nawi, Aliff; Mahalle, Salwa

    2014-01-01

    This study aimed to present a practical framework for designing a values teaching program in the youth education system. The choice of content, the nature of the students with respect to learning and their perception about the selected content for teaching values were studied. The study follows a Needs analysis design which drew upon document…

  16. E-Health Initiative and Customer's Expectation: Case Brunei

    CERN Document Server

    Almunawar, Mohammad Nabil; Low, Patrick Kim Cheng; Anshari, Muhammad

    2012-01-01

    This paper is to determine the dimension of e-health services in Brunei Darussalam (Brunei) from customers' perspective. It is to identify, understand, analyze and evaluate public's expectation on e-health in Brunei. A questionnaire was designed to gather quantitative and qualitative data to survey patients, patient's family, and health practitioners at hospitals, clinics, or home care centers in Brunei starting from February to March, 2011. A 25-item Likert-type survey instrument was specifically developed for this study and administered to a sample of 366 patients. The data were analyzed to provide initial ideas and recommendation to policy makers on how to move forward with the e-health initiative as a mean to improve healthcare services. The survey revealed that there exists a high demand and expectation from people in Brunei to have better healthcare services accessible through an e-health system in order to improve health literacy as well as quality and efficiency of healthcare. Regardless of the limita...

  17. Customer expectation of e-health systems in Brunei Darussalam.

    Science.gov (United States)

    Almunawar, Mohammad Nabil; Wint, Zaw; Low, Kim Cheng Patrick; Anshari, Muhammad

    2012-01-01

    This study seeks to determine the dimension of e-health services in Brunei Darussalam from the customer's perspective. The study seeks to identify, understand, analyze, and evaluate the public's expectation of e-health in Brunei Darussalam. A questionnaire was designed to gather quantitative and qualitative data to survey patients, the patient's family, and health practitioners at hospitals, clinics, or home care centers in Brunei Darussalam from February to March 2011. A 25-item Likert-type survey instrument was specifically developed for this study and administered to a sample of 366 patients. These data were analyzed to provide initial ideas and recommendations to policy makers on how to move forward with the e-health initiative as a means to improve health care services. The survey revealed that there is a high demand and expectation from people of Brunei to have better health care services through an e-health system in order to improve health literacy as well as quality and efficiency of health care. Regardless of the limitations of the survey, the general public has responded to the questionnaire with great support for the abilities of an e-health system. The results of the survey provide a solid foundation for our ongoing research project to proceed further to develop the model of e-health and subsequently to develop a system prototype that incorporates expectations from patients.

  18. Total and free available fluoride in toothpastes in Brunei, Cambodia, Laos, the Netherlands and Suriname

    NARCIS (Netherlands)

    Benzian, H.; Holmgren, C.J.; Buijs, M.; van Loveren, C.; van der Weijden, F.; van Palenstein Helderman, W.H.

    2012-01-01

    OBJECTIVES: This study assessed total and free fluoride concentrations in samples of toothpaste from Brunei, Cambodia, Laos, the Netherlands and Suriname, and investigated the labelling practices of the respective manufacturers. MATERIALS AND METHODS: Convenience samples were bought in the five

  19. A new technique for inventory of permanent plots in tropical forests: a case study from lowland dipterocarp forest in Kuala Belalong, Brunei Darussalam

    NARCIS (Netherlands)

    Hédl, R.; Svátek, M.; Dančák, M.; Rodzay, A.W.; Salleh, M.A.B.; Kamariah, A.S.

    2009-01-01

    This paper describes a new technique for inventory of permanent plots in tropical forests and presents the results of its application in a 1 ha permanent plot in a lowland dipterocarp forest at Kuala Belalong, Ulu Temburong National Park, Brunei Darussalam. The technique is based on mapping of posit

  20. A Comparative Study of Teachers' Pedagogical Competencies in Supporting Children with Learning Difficulties in Primary Schools in Ghana and Brunei Darussalam

    Science.gov (United States)

    Abosi, Okechukwu; Alhassan, Abdul Razak Kuyini

    2017-01-01

    Teachers' pedagogical competencies level is increasingly affecting the implementation of inclusive education policy in many countries. The aimed at comparing primary school teachers' competence levels in supporting children with learning difficulties in Brunei Darussalam and Ghana. Descriptive survey design was used and 188 primary school teachers…

  1. A Comparative Study of Teachers' Pedagogical Competencies in Supporting Children with Learning Difficulties in Primary Schools in Ghana and Brunei Darussalam

    Science.gov (United States)

    Abosi, Okechukwu; Alhassan, Abdul Razak Kuyini

    2017-01-01

    Teachers' pedagogical competencies level is increasingly affecting the implementation of inclusive education policy in many countries. The aimed at comparing primary school teachers' competence levels in supporting children with learning difficulties in Brunei Darussalam and Ghana. Descriptive survey design was used and 188 primary school teachers…

  2. Automated peritoneal dialysis in Brunei Darussalam.

    Directory of Open Access Journals (Sweden)

    Ishrat KAMAL

    2011-04-01

    Full Text Available Introduction: Chronic kidney disease in Brunei Darussalam is a growing problem. The number of patients reaching end stage kidney failure has increased dramatically in the last ten years. Currently, most are managed with haemodialysis while a smaller proportion is managed with continuous ambulatory peritoneal dialysis (CAPD. Automated peritoneal dialysis (APD is a form of peritoneal dialysis and has been used in Brunei Darussalam since May 2008. Materials and Methods: Eight patients participated in this prospective clinical trial. As all APD patients were previously on CAPD, comparisons are made between the outcomes of APD against CAPD. Results: The median and mean age of APD patients were 42 and 45.5 ± 12.73 years respectively. After switching to APD, the serum haemoglobin and albumin improved from 10.56 ± 1.95 gm/L and 27.88 ± 7.71 gm/dL to 12.26 ± 1.82 gm/L and 33.63 ± 6.89 gm/dL respectively (p values <0.05. This corresponded to improvements in seven (87.5% and six (75% patients respectively in both parameters. Erythropoietin requirement was reduced in six (75% patients, including three (37.5% patients who were able to stop erythropoietin completely. There was no peritonitis encountered. All patients reported improved quality of life with better sleep, appetite and general well-being. Conclusions: Our study showed that APD was as good as CAPD with improvement seen in both laboratory and quality of life parameters. There was also reduction in erythropoietin requirement. Based on these findings, we will actively encourage and promote APD usage as oppose to CAPD usage in our population.

  3. Põhjapanevad uuendused Brunei naftasultanaadis / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2004-01-01

    Parlamenti ehk Seadusandlikku Kogu pole Bruneis eksisteerinud 42 aastat, sest 1962. a. saatis valitseja Omar Ali Saifuddin selle laiali. 25. sept. tuli 21-liikmeline parlament kokku. Bruneist kui heaolu riigist

  4. Põhjapanevad uuendused Brunei naftasultanaadis / Allan Espenberg

    Index Scriptorium Estoniae

    Espenberg, Allan

    2004-01-01

    Parlamenti ehk Seadusandlikku Kogu pole Bruneis eksisteerinud 42 aastat, sest 1962. a. saatis valitseja Omar Ali Saifuddin selle laiali. 25. sept. tuli 21-liikmeline parlament kokku. Bruneist kui heaolu riigist

  5. Brunei Darussalam; Statistical Appendix

    OpenAIRE

    International Monetary Fund

    2006-01-01

    In this study, the following are discussed: nominal GDP by economic activity and expenditure, quarterly nominal GDP by economic activity and expenditure, composition of nominal GDP by economic activity and expenditure, quarterly composition of nominal GDP by economic activity and expenditure, real GDP by economic activity and expenditure, quarterly real GDP by economic activity and expenditure, growth in real GDP by economic activity and expenditure, growth in quarterly real GDP by economic a...

  6. Haze Research in Brunei Darussalam During the 1998 Episode

    Science.gov (United States)

    Radojevic, M.

    - Brunei Darussalam experienced a severe haze episode between the beginning of February and the end of April 1998 due mainly to local peat and forest fires in Brunei and in neighbouring Sabah and Sarawak. The extensive research studies of the haze carried out in Brunei are outlined together with selected results. Particulate matter (PM10) was the only significant criteria pollutant and it exceeded WHO guidelines and accepted air quality standards on most days during the haze episode. Gaseous criteria pollutants (CO, SO2, NO2, O3) were generally well below WHO guidelines and at these concentrations they are expected to have no significant health or environmental effects. Measurements of volatile organic compounds (VOCs) revealed the presence of benzene, toluene, ethylbenzene, and xylenes (BTEX), aldehydes, phenol, and polynuclear aromatic hydrocarbons (PAHs). Personal exposure monitoring of PM10 revealed significant differences in exposure patterns between different individuals depending on the location, time and activity. Data on outpatient visits showed an increase for some illnesses (e.g., acute respiratory infection) during the months of haze. No significant impacts of haze on rainwater acidity or deposition were noted. Emission factors for some volatile compounds were determined in combustion experiments in which peat was burned at temperatures typical of smouldering.

  7. Exponents of Politeness in Brunei English

    Science.gov (United States)

    Ho, Debbie G. E.

    2009-01-01

    This paper is based on the premise that not much is known about how English modal verbs are used to express politeness in Non-Native English speaking (NNEs) contexts. It explores the use of the past and non-past forms of the request modals "will" and "can" in Brunei, a NNEs country located in Southeast Asia. Specifically, it…

  8. CODE CHOICE WITHIN INTERCULTURAL COMMUNICATION AMONG ETHNIC MINORITY IN BRUNEI

    Directory of Open Access Journals (Sweden)

    Fatimah Chuchu

    2015-07-01

    Full Text Available The influences of globalisation and multilingualism have caused linguistic diversity and emergence of interesting and unique sociolinguistic phenomena, for instance, language contact in intercultural communication. As the study of intercultural communication has yet to be studied at large, this research takes the opportunity to embark on a descriptive study of code choice within intercultural communication, relating to the ethnic minorities in Brunei Darussalam. This investigation aims to identify these ethnics’ preferable code choice within intercultural communication, and their needs and motivations practising those codes in a shared multilingual setting. Involving empirical investigation, this study was conducted on 60 native Brunei ethnics in Mukim Ukong, Tutong District. Research found that study involving multilingual settings and intercultural communications are rather relatively complex sociolinguistic phenomena, where speakers would employ different dialects or languages at an episode of communication, but still mutually understood by each other. To some extent, some speakers also accommodate their speech styles or languages to ease communication process between parties. The hegemony of globalisation, local vernacular, speakers’ background and setting are among others influenced the selection of their everyday code choice.

  9. Total and free available fluoride in toothpastes in Brunei, Cambodia, Laos, the Netherlands and Suriname

    NARCIS (Netherlands)

    H. Benzian; C.J. Holmgren; M. Buijs; C. van Loveren; F. van der Weijden; W.H. van Palenstein Helderman

    2012-01-01

    OBJECTIVES: This study assessed total and free fluoride concentrations in samples of toothpaste from Brunei, Cambodia, Laos, the Netherlands and Suriname, and investigated the labelling practices of the respective manufacturers. MATERIALS AND METHODS: Convenience samples were bought in the five coun

  10. Proifles of autoimmune hepatitis in Brunei Darussalam

    Institute of Scientific and Technical Information of China (English)

    Anand Jalihal; Pemasari Upali Telisinghe; Vui Heng Chong

    2009-01-01

    BACKGROUND: Autoimmune hepatitis (AIH) is a chronic inlfammatory disease of the liver. Data on the disease remain scarce in the Southeast Asia region. This study was undertaken to assess the proifles of AIH in Brunei Darussalam. METHODS: Nineteen patients with AIH treated at the hepatology clinic, RIPAS Hospital (up until December 2008) were reviewed. Demographic, laboratory, histologic, clinical, and therapeutic data of the patients were collected. RESULTS: The median age of the 19 patients at diagnosis was 52 years (range 33-70) with a male to female ratio of 1∶3.75. All patients were diagnosed with typeⅠAIH. The prevalence rate of the disease was 5.61/100 000 and was higher in the Chinese than in Malays and Indigenous people. Commonly seen presentations were abnormal liver function (52.6%), icteric hepatitis (36.8%), and decompensated liver disease (10.5%). Histologically advanced ifbrosis was found in 47.4% and cirrhosis in 21.1% of the patients. Immune-mediated diseases were present in 36.8%. In a follow-up for 31 months (range 0.25-102), three patients died, 2 had progressive liver failure and 1 had lymphoma. Complete biochemical response was seen in 75%of the patients, partial response in 12.5%, and no response in 12.5%. HLA DRB1*03 (DR3) was detected in 18.2%of the patients and DRB1*04 (DR4) in 45.5%. There were signiifcant associations between HLA Cw7 (P=0.038) and DQB1*04 (P=0.007). CONCLUSIONS: The data of the 19 patients were comparable to those reported in the literature. Most of the patients were found to have abnormal biochemistry. There were signiifcant associations between HLA Cw7 and DQB1*04, but not between DRB1*03 (DR3) and DRB1*04 (DR4).

  11. Measurement and dimension of road fatality in Brunei.

    Science.gov (United States)

    Haque, Mohammed Ohidul

    2011-03-01

    In this article, we have investigated the pattern of road fatality in Brunei. It is seen from this analysis that road fatality in Brunei was one of the highest in the world in the early 1990s, but has been significantly reduced over the years, and is now one of the lowest in the world. Preliminary investigation shows that young male drivers are responsible for most road fatalities in Brunei. We have also fitted a linear regression model and found that road fatality is significantly positively related to people aged 18-24 years and new registered vehicles, both of which are expected to grow with the growth of population and economic development. Hence, road fatality in Brunei is also expected to grow unless additional effective road safety countermeasures are introduced and implemented to reduce road toll. Negative coefficient is observed for trend variable, indicating the reduction of road fatality due to the combined effects of improvements of vehicle safety, road design, medical facilities and road safety awareness among road user groups. However, short-term road fatality analysis based on monthly data indicates that the coefficient of the trend variable is positive, implying that in recent months road fatalities are increasing in Brunei, which is supported by media reports. We have compared Brunei's road fatality data with Australia, Singapore and Malaysia and found that Brunei's road fatality rate is lower than Singapore and Malaysia, but higher than Australia. This indicates that there are still opportunities to reduce road fatalities in Brunei if additional effective road safety strategies are implemented like in Australia without interfering in the economic and social development of Brunei.

  12. Modernity and Globalisation: Is the Presence of English and of Cultural Products in English a Sign of Linguistic and Cultural Imperialism? Results of a Study Conducted in Brunei Darussalam and Malaysia

    Science.gov (United States)

    Coluzzi, Paolo

    2012-01-01

    This article looks at language use and attitudes in Brunei Darussalam and Malaysia through a survey conducted among 88 university students for each country. The focus of the article, however, is on the expanding use of English, particularly as far as media consumption is concerned, relating this with issues of globalisation and linguistic and…

  13. Chinese-Brunei Oil Cooperation Benefits Two Countries

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Thanks to joint efforts by both sides, the trade and economic relations between China and Brunei have in recent years witnessed a steady and healthy development, which will no doubt benefit the two countries and the two peoples.

  14. Evaluation of national emissions inventories of anthropogenic air pollutants for Brunei Darussalam

    Science.gov (United States)

    Dotse, Sam-Quarcoo; Dagar, Lalit; Petra, Mohammad Iskandar; De Silva, Liyanage C.

    2016-05-01

    Haze and other air pollution related problems are getting more significant in Brunei Darussalam but till date there is absence of comprehensive national emission inventory for Brunei Darussalam. Although there are few regional and global inventories available for Brunei Darussalam, large variations in the emission estimates exist in these datasets. Therefore, there is an important need for an updated inventory, based on data available from government and other sources. This study presents a sector-wise anthropogenic emission estimates and trends (2001-2012) for the pollutants CO2, CH4, N2O, NOX, NMVOC, CO, SOX, and PM10. The results suggest no significant contributions from residential sector (road transport is the main contributor for most of the pollutants. CO2 is largely emitted by power plants (∼72% in 2001 and∼ 62% in 2012) and the main source of CH4 is Solid waste disposal and wastewater handling (∼92%). There were also significant contributions from industrial processes and solvent use to NMVOC and PM10 emissions (∼74% and ∼45% respectively).

  15. Favourable outcome after peripartum cardiomyopathy: a ten-year study on peripartum cardiomyopathy in a university hospital.

    Science.gov (United States)

    Chee, Kok-Han

    2013-01-01

    Peripartum cardiomyopathy (PPCM) is an uncommon form of congestive heart failure, affecting obstetric patients around the time of delivery. The epidemiology of PPCM is infrequently reported. This study was undertaken to define the prevalence, presentation and outcome of PPCM among women giving birth in a teaching hospital in Malaysia. A retrospective case record analysis was conducted on all patients admitted and diagnosed with PPCM at the University Malaya Medical Centre, Kuala Lumpur, Malaysia, from 1 January 2000 to 31 December 2009. All deliveries were undertaken in the same hospital. A total of 12 patients were diagnosed with PPCM during the ten-year study period. The prevalence of PPCM was 2.48 in 100,000 (1 in 40,322) live births. Nine women were diagnosed with PPCM within five months of delivery. Three women had twin pregnancies. There was one death in the group (mortality rate 8.3%). The mean left ventricular ejection fraction at the time of diagnosis was 28.9% ± 8.5% (range 15%-40%). Following the index event, left ventricular function normalised in six of the nine patients (66.7%) who underwent subsequent echocardiography one year later. All patients were treated with standard heart failure therapy. Two patients with normalised left ventricular function had subsequent pregnancies - one pregnancy was terminated at seven weeks and the other patient delivered uneventfully at full term. PPCM is uncommon. The outcome in our series was favourable, with 66.7% of patients with PPCM recovering their left ventricular function. The mortality rate was 8.3%.

  16. Healthcare in Brunei Darussalam: Flying Doctor Service (Part I.

    Directory of Open Access Journals (Sweden)

    2013-06-01

    Full Text Available Since the introduction of an official healthcare system in Brunei in 1907, service provision continued to improve, albeit slowly. Some of the limiting factors included the lack of infrastructure in healthcare, roads and transportation and workforce (limited to dressers and a visiting doctor from Labuan in the initial part, and limited knowledge of the bygone era.

  17. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

    NARCIS (Netherlands)

    Boers, I.; Muskiet, F.A.J.; Berkelaar, E.; Schut, E.; Penders, R.; Hoenderdos, K.; Jong, de M.C.; Wichers, H.J.

    2014-01-01

    Background The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a

  18. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome : a randomized controlled pilot-study

    NARCIS (Netherlands)

    Boers, Inge; Muskiet, Frits A. J.; Berkelaar, Evert; Schut, Erik; Penders, Ria; Hoenderdos, Karine; Wichers, Harry J.; Jong, Miek C.

    2014-01-01

    Background: The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a

  19. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome : a randomized controlled pilot-study

    NARCIS (Netherlands)

    Boers, Inge; Muskiet, Frits A. J.; Berkelaar, Evert; Schut, Erik; Penders, Ria; Hoenderdos, Karine; Wichers, Harry J.; Jong, Miek C.

    2014-01-01

    Background: The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a Paleolit

  20. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

    NARCIS (Netherlands)

    Boers, I.; Muskiet, F.A.J.; Berkelaar, E.; Schut, E.; Penders, R.; Hoenderdos, K.; Jong, de M.C.; Wichers, H.J.

    2014-01-01

    Background The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a Paleolith

  1. Favourability: concept, distinctive characteristics and potential usefulness

    Science.gov (United States)

    Acevedo, Pelayo; Real, Raimundo

    2012-07-01

    The idea of analysing the general favourability for the occurrence of an event was presented in 2006 through a mathematical function. However, even when favourability has been used in species distribution modelling, the conceptual framework of this function is not yet well perceived among many researchers. The present paper is conceived for providing a wider and more in-depth presentation of the idea of favourability; concretely, we aimed to clarify both the concept and the main distinctive characteristics of the favourability function, especially in relation to probability and suitability, the most common outputs in species distribution modelling. As the capabilities of the favourability function go beyond species distribution modelling, we also illustrate its usefulness for different research disciplines for which this function remains unknown. In particular, we stressed that the favourability function has potential to be applied in all the cases where the probability of occurrence of an event is analysed, such as, for example, habitat selection or epidemiological studies.

  2. Psychosocial Work Stressors, Work Fatigue, and Musculoskeletal Disorders: Comparison between Emergency and Critical Care Nurses in Brunei Public Hospitals.

    Science.gov (United States)

    Abdul Rahman, Hanif; Abdul-Mumin, Khadizah; Naing, Lin

    2017-03-01

    Little evidence estimated the exposure of psychosocial work stressors, work-related fatigue, and musculoskeletal disorders for nurses working in South-East Asian region, and research on this subject is almost nonexistent in Brunei. The main aim of our study was to provide a comprehensive exploration and estimate exposure of the study variables amongst emergency (ER) and critical care (CC) nurses in Brunei. The study also aims to compare whether experiences of ER nurses differ from those of CC nurses. This cross-sectional study was implemented in the ER and CC departments across Brunei public hospitals from February to April 2016 by using Copenhagen Psychosocial Questionnaire II, Occupational Fatigue Exhaustion Recovery scale, and Cornell Musculoskeletal Discomfort Questionnaire. In total, 201 ER and CC nurses (82.0% response rate) participated in the study. Quantitative demands of CC nurses were significantly higher than ER nurses. Even so, ER nurses were 4.0 times more likely [95% confidence interval (2.21, 7.35)] to experience threats of violence, and 2.8 times more likely [95% confidence interval: (1.50, 5.29)] to experience chronic fatigue. The results revealed that nurses experienced high quantitative demands, work pace, stress, and burnout. High prevalence of chronic and persistent fatigue, threats of violence and bullying, and musculoskeletal pain at the neck, shoulder, upper and lower back, and foot region, was also reported. This study has provided good estimates for the exposure rate of psychosocial work stressors, work-related fatigue, and musculoskeletal disorders among nurses in Brunei. It provided important initial insight for nursing management and policymakers to make informed decisions on current and future planning to provide nurses with a conducive work environment. Copyright © 2017. Published by Elsevier B.V.

  3. The Suitability of the EPQ-R Short Scale for Counselling Brunei Student Teachers when Administered in English and Malay Languages

    Science.gov (United States)

    Mundia, Lawrence; Abu Bakar, Hj Abu Zahari Bin

    2010-01-01

    The study investigated the psychometric properties of the Eysenck Personality Questionnaire-Revised (EPQ-R) Short Scale administered to two groups of Brunei trainee teachers of both genders taking psychology courses in English (117 students) and Malay (106 students). The extraversion scale had the most problematic items. Both administrations…

  4. Species Favourability Shift in Europe due to Climate Change: A Case Study for Fagus sylvatica L. and Picea abies (L. Karst. Based on an Ensemble of Climate Models

    Directory of Open Access Journals (Sweden)

    Wolfgang Falk

    2013-01-01

    Full Text Available Climate is the main environmental driver determining the spatial distribution of most tree species at the continental scale. We investigated the distribution change of European beech and Norway spruce due to climate change. We applied a species distribution model (SDM, driven by an ensemble of 21 regional climate models in order to study the shift of the favourability distribution of these species. SDMs were parameterized for 1971–2000, as well as 2021–2050 and 2071–2100 using the SRES scenario A1B and three physiological meaningful climate variables. Growing degree sum and precipitation sum were calculated for the growing season on a basis of daily data. Results show a general north-eastern and altitudinal shift in climatological favourability for both species, although the shift is more marked for spruce. The gain of new favourable sites in the north or in the Alps is stronger for beech compared to spruce. Uncertainty is expressed as the variance of the averaged maps and with a density function. Uncertainty in species distribution increases over time. This study demonstrates the importance of data ensembles and shows how to deal with different outcomes in order to improve impact studies by showing uncertainty of the resulting maps.

  5. A Preliminary Assessment of Asymptomatic Bacteriuria of Pregnancy in Brunei Darussalam

    Science.gov (United States)

    MUHARRAM, Siti Hanna; GHAZALI, Siti Nur Bazilah; YAAKUB, Hajah Roselina; ABIOLA, Oduola

    2014-01-01

    Background: Asymptomatic bacteriuria describes a condition in which urine culture reveals a significant growth of pathogenic bacteria, specifically greater than 105 of colony-forming units per millilitre of urine. It has a direct bearing on the health of a pregnant woman, her pregnancy and consequently the foetus. Thus, this study investigated the prevalence of asymptomatic bacteriuria of pregnancy in Raja Isteri Pengiran Anak Saleha (RIPAS) Hospital, the premiere tertiary hospital in Brunei Darussalam. Methods: A total of 170 pregnant women who were visiting the Department of Obstetrics and Gynaecology at RIPAS Hospital for routine antenatal care between February and March 2011 volunteered for this cross-sectional study. They did not present with any clinical symptoms of bacteriuria or indeed any other illness. They were investigated for bacteriuria by urine microscopy, culture, and sensitivity. Results: Urine samples from seven of the women produced significant bacterial growth, showing a prevalence of 4.1%. The organisms isolated were Klebsiella species (2.94%) and Escherichia coli (1.18%); these bacteria were both sensitive to amoxicillin, vancomycin, tetracycline, and erythromycin. Conclusion: Brunei has a similar prevalence of asymptomatic bacteriuria to other South-East Asian countries. PMID:24876805

  6. Prediction of employer–employee relationships from sociodemographic variables and social values in Brunei public and private sector workers

    Directory of Open Access Journals (Sweden)

    Mundia L

    2017-07-01

    Full Text Available Lawrence Mundia, Salwa Mahalle, Rohani Matzin, Gamal Abdul Nasir Zakaria, Nor Zaiham Midawati Abdullah, Siti Norhedayah Abdul Latif Psychological Studies and Human Development Academic Group, Sultan Hassanal Bolkiah Institute of Education, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Darussalam Abstract: The purpose of the study was to identify the sociodemographic variables and social value correlates and predictors of employer–employee relationship problems in a random sample of 860 Brunei public and private sector workers of both genders. A quantitative field survey design was used and data were analyzed by correlation and logistic regression. The rationale and justification for using this approach is explained. The main sociodemographic correlates and predictors of employer–employee relationship problems in this study were educational level and the district in which the employee resided and worked. Other correlates, but not necessarily predictors, of employer–employee relationship problems were seeking help from the Bomo (traditional healer; obtaining help from online social networking; and workers with children in the family. The two best and most significant social value correlates and predictors of employer–employee relationship problems included interpersonal communications; and self-regulation and self-direction. Low scorers on the following variables were also associated with high likelihood for possessing employer–employee relationship problems: satisfaction with work achievements; and peace and security, while low scorers on work stress had lower odds of having employer–employee relationship problems. Other significant social value correlates, but not predictors of employer–employee relationship problems were self-presentation; interpersonal trust; peace and security; and general anxiety. Consistent with findings of relevant previous studies conducted elsewhere, there were the variables that correlated

  7. Public Art Education in Brunei Darussalam: The Cultural Language of Community Murals

    Science.gov (United States)

    Ho, Kong

    2014-01-01

    Two mural projects in Brunei offer insight into the specific and universal aspects of public art education and community art making. This article describes how the author used his initiative and experience as a muralist to plan and implement two community art research projects in Bandar Seri Begwan, the capital of Brunei Darussalam. A premise of…

  8. English Language Teaching in Brunei: A View through a Critical Lens

    Science.gov (United States)

    Barry, Clayton

    2011-01-01

    The small sultanate of Brunei, located on the island of Borneo in the South China Sea, introduced bilingual education shortly after independence. As a consequence, Brunei's Ministry of Education outsourced much of its English language teaching requirements to qualified expatriate teachers. Despite over 25 years of systemic English language…

  9. Developmental Interdependence Hypothesis Revisited in the Brunei Classroom [and] A Response.

    Science.gov (United States)

    Liew, Elizabeth M.; Saravanan, Vanithamani

    1996-01-01

    Focuses on the importance of developing the native language (L1), i.e., "Bahasa Melayu," as a firm foundation for the learning of a second language (L2) in Brunei and analyzes problems facing learners of "Bahasa Melayu" and English in Brunei classrooms. Saravanan's response focuses on the structure of the Brunesian bilingual…

  10. Healthcare Pioneers: The Nurses of Brunei Darussalam (Part II

    Directory of Open Access Journals (Sweden)

    2013-02-01

    Full Text Available In any healthcare system, nurses play a vital role in the delivering of medical and health services. A significant point in the history of nursing in Brunei was the training of two local women on ’ward utility’ of Maternal and Child services in 1932. In 1933, a local Maternal and Child Nurse was appointed and another trained as probationer midwife. In 1936, seven male officers were engaged in this service. Two nurses were also trained to provide educational services for antenatal women. Importance was placed on midwifery due to the high obstetric complications and maternal and infant mortality rates.

  11. Prediction of climate change in Brunei Darussalam using statistical downscaling model

    Science.gov (United States)

    Hasan, Dk. Siti Nurul Ain binti Pg. Ali; Ratnayake, Uditha; Shams, Shahriar; Nayan, Zuliana Binti Hj; Rahman, Ena Kartina Abdul

    2017-06-01

    Climate is changing and evidence suggests that the impact of climate change would influence our everyday lives, including agriculture, built environment, energy management, food security and water resources. Brunei Darussalam located within the heart of Borneo will be affected both in terms of precipitation and temperature. Therefore, it is crucial to comprehend and assess how important climate indicators like temperature and precipitation are expected to vary in the future in order to minimise its impact. This study assesses the application of a statistical downscaling model (SDSM) for downscaling General Circulation Model (GCM) results for maximum and minimum temperatures along with precipitation in Brunei Darussalam. It investigates future climate changes based on numerous scenarios using Hadley Centre Coupled Model, version 3 (HadCM3), Canadian Earth System Model (CanESM2) and third-generation Coupled Global Climate Model (CGCM3) outputs. The SDSM outputs were improved with the implementation of bias correction and also using a monthly sub-model instead of an annual sub-model. The outcomes of this assessment show that monthly sub-model performed better than the annual sub-model. This study indicates a satisfactory applicability for generation of maximum temperatures, minimum temperatures and precipitation for future periods of 2017-2046 and 2047-2076. All considered models and the scenarios were consistent in predicting increasing trend of maximum temperature, increasing trend of minimum temperature and decreasing trend of precipitations. Maximum overall trend of Tmax was also observed for CanESM2 with Representative Concentration Pathways (RCP) 8.5 scenario. The increasing trend is 0.014 °C per year. Accordingly, by 2076, the highest prediction of average maximum temperatures is that it will increase by 1.4 °C. The same model predicts an increasing trend of Tmin of 0.004 °C per year, while the highest trend is seen under CGCM3-A2 scenario which is 0.009

  12. Public attitudes to the promotion of genomic crop studies in Japan: correlations between genomic literacy, trust, and favourable attitude.

    Science.gov (United States)

    Ishiyama, Izumi; Tanzawa, Tetsuro; Watanabe, Maiko; Maeda, Tadahiko; Muto, Kaori; Tamakoshi, Akiko; Nagai, Akiko; Yamagata, Zentaro

    2012-05-01

    This study aimed to assess public attitudes in Japan to the promotion of genomic selection in crop studies and to examine associated factors. We analysed data from a nationwide opinion survey. A total of 4,000 people were selected from the Japanese general population by a stratified two-phase sampling method, and 2,171 people participated by post; this survey asked about the pros and cons of crop-related genomic studies promotion, examined people's scientific literacy in genomics, and investigated factors thought to be related to genomic literacy and attitude. The relationships were examined using logistic regression models stratified by gender. Survey results showed that 50.0% of respondents approved of the promotion of crop-related genomic studies, while 6.7% disapproved. No correlation was found between literacy and attitude towards promotion. Trust in experts, belief in science, an interest in genomic studies and willingness to purchase new products correlated with a positive attitude towards crop-related genomic studies.

  13. Excessive alcohol consumption favours high risk polyp or colorectal cancer occurrence among patients with adenomas: a case control study

    OpenAIRE

    Bardou, M; Montembault, S; Giraud, V.; Balian, A; Borotto, E; Houdayer, C.; Capron, F.; Chaput, J-C; Naveau, S

    2002-01-01

    Background and aims: Excessive alcohol consumption is a risk factor for developing colorectal adenomas. This study aimed to investigate the influence of excessive alcohol consumption on the occurrence of high risk polyps (adenoma ≥10 mm, villous component, high grade dysplasia) or colorectal cancer among patients with at least one colonic adenoma.

  14. The Roles and Attributes of the Clinical Teacher that Contribute to Favourable Learning Environments: A Case Study from Physiotherapy

    Directory of Open Access Journals (Sweden)

    DV Ernstzen

    2012-12-01

    Full Text Available The quality of clinical education is dependenton learning experiences. The clinical teacher plays a key role insuccessful clinical education.The aims of the study were to determine which roles and attributesof physiotherapy clinical teachers contribute to a supportiveclinical learning environment according to physiotherapy studentsand their clinical teachers.The study protocol was approved by the Committee for HumanResearch at Stellenbosch University. A qualitative research designwas used. An interview schedule was developed based on existing literature. Data was analyzed using contentanalysis. Data was coded, categorized and conceptualized into key themes and patterns.All third year (n=40 and fourth year (n=40 undergraduate physiotherapy students and their clinical teachers(n=37 were eligible to participate. Semi-structured individual interviews were conducted with a purposivesample consisting of six third-year students, six fourth-year students and six clinical teachers (n=18. Written informedconsent was obtained from all participants prior to the interviews.The teacher as role model and facilitator of learning was emphasised. The attributes of the clinical teacher thatcreated a supportive learning environment were approachability, recognising student abilities and good communicationskills. The value of active involvement and individualism in learning was highlighted.The study confirmed that the clinical teacher is pivotal in the success of a physiotherapy clinical education program.The findings agree with the large body of international literature about supportive clinical learning environments.

  15. Brunei's teacher education programs: insights into students' coping and help-seeking strategies to challenges.

    Science.gov (United States)

    Mundia, Lawrence; Shahrill, Masitah; Jaidin, Jainatul Halida; Jawawi, Rosmawijah; Mahadi, Mar Aswandi

    2016-01-01

    Brunei started implementing its two main reformed teacher education programs, MTeach and MEd, in 2009. The reasons for these innovations included upgrading the standard of teacher training, increasing teaching effectiveness, and improving the quality of education in the country. The purpose of this study was to determine how student teachers coped with and sought help on the challenging programs. Using an online survey design, 76 randomly selected recent graduate teachers responded appropriately to questionnaires administered to them by email. The obtained quantitative research information included demographic, coping, and help-seeking data, all analyzed by SPSS Version 22. Participants endorsed both the productive and nonproductive coping strategies. In addition, they depended more on peers, teachers and internet sources for help. Four major findings were obtained. First, task-oriented coping was the most important and significant predictor of success on the MTeach and MEd programs. Second, females had a higher likelihood of success compared to males (OR = 22.760, 95 % CI for OR = 12.848-40.320). Third, students who consulted relevant internet resources had higher odds for succeeding compared to those who did not (OR = 2.237, 95 % CI 1.196-4.183). Fourth, less-able students who collaboratively worked with the more-able peers were nearly two times more likely to perform better than those who did not (OR = 1.982, 95 % CI 1.082-3.630). Coping and help-seeking were positively and significantly related to academic achievement on the two Brunei main teacher education programs. Evidence from the present study suggested that vulnerable and at-risk trainee teachers needed appropriate interventions (educational, counseling and psychotherapy) related to effective use of task-oriented coping and seeking help via cooperative learning, internet sources, and teacher consultations,. Further research with interview probes was recommended to gain additional information

  16. Sociodemographic variables and social values: relationship with work-attendance problems in Brunei public- and private-sector employees

    Directory of Open Access Journals (Sweden)

    Mundia L

    2017-08-01

    Full Text Available Lawrence Mundia, Salwa Mahalle, Rohani Matzin, Gamal Abdul Nasir Zakaria, Nor Zaiham Midawati AbdullahPsychological Studies and Human Development Academic Group, Sultan Hassanal Bolkiah Institute of Education, Universiti Brunei Darussalam, Bandar Seri Begawan, BruneiObjective: The study investigated the degree to which selected sociodemographic variables and social values were related to work-attendance problems in a random sample of 860 Brunei public- and private-sector employees and the nature of this relationship.Materials and methods: This quantitative study used the field-survey approach to administer research instruments directly to participants. This enabled the researchers to help participants who needed assistance in completing the measures properly, so as to increase the number of usable returns.Results: Two sociodemographic variables (seeking help from a counselor/psychologist and marital status correlated significantly with work attendance. Private-sector employees were more likely to have work-attendance problems than government workers. Both single and married employees and the chief wage earner in the household were more likely to have work-attendance issues to deal with compared to their counterparts. However, employees who sought help from a counselor/psychologist were far less likely to have work-attendance problems compared to those who did not get such help. The most significant social-value correlates with work-attendance problems were interpersonal communication, employer–employee relationship, work-stress problems, self-presentation, self-regulation, self-direction, and interpersonal trust. Self-regulation, self-direction, and satisfaction with work-related achievements significantly predicted work-attendance problems positively, while interpersonal communication problems and work-stress problems predicted work-attendance problems negatively. Low scorers on self-regulation and self-direction, as well as on satisfaction

  17. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study.

    Science.gov (United States)

    Boers, Inge; Muskiet, Frits Aj; Berkelaar, Evert; Schut, Erik; Penders, Ria; Hoenderdos, Karine; Wichers, Harry J; Jong, Miek C

    2014-10-11

    The main goal of this randomized controlled single-blinded pilot study was to study whether, independent of weight loss, a Palaeolithic-type diet alters characteristics of the metabolic syndrome. Next we searched for outcome variables that might become favourably influenced by a Paleolithic-type diet and may provide new insights in the pathophysiological mechanisms underlying the metabolic syndrome. In addition, more information on feasibility and designing an innovative dietary research program on the basis of a Palaeolithic-type diet was obtained. Thirty-four subjects, with at least two characteristics of the metabolic syndrome, were randomized to a two weeks Palaeolithic-type diet (n = 18) or an isoenergetic healthy reference diet, based on the guidelines of the Dutch Health Council (n = 14). Thirty-two subjects completed the study. Measures were taken to keep bodyweight stable. As primary outcomes oral glucose tolerance and characteristics of the metabolic syndrome (abdominal circumference, blood pressure, glucose, lipids) were measured. Secondary outcomes were intestinal permeability, inflammation and salivary cortisol. Data were collected at baseline and after the intervention. Subjects were 53.5 (SD9.7) year old men (n = 9) and women (n = 25) with mean BMI of 31.8 (SD5.7) kg/m2. The Palaeolithic-type diet resulted in lower systolic blood pressure (-9.1 mmHg; P = 0.015), diastolic blood pressure (-5.2 mmHg; P = 0.038), total cholesterol (-0.52 mmol/l; P = 0.037), triglycerides (-0.89 mmol/l; P = 0.001) and higher HDL-cholesterol (+0.15 mmol/l; P = 0.013), compared to reference. The number of characteristics of the metabolic syndrome decreased with 1.07 (P = 0.010) upon the Palaeolithic-type diet, compared to reference. Despite efforts to keep bodyweight stable, it decreased in the Palaeolithic group compared to reference (-1.32 kg; P = 0.012). However, favourable effects remained after post-hoc adjustments for this

  18. SYSTEM OF ACTIONS TO FAVOUR THE INTERDISCIPLINARITY IN THE CAREER OF SOCIOCULTURAL STUDIES / SISTEMA DE ACCIONES PARA FAVORECER LA INTERDISCIPLINARIEDAD EN LA CARRERA DE ESTUDIOS SOCIOCULTURALES

    Directory of Open Access Journals (Sweden)

    José Luis Marañón Rodríguez

    Full Text Available To form a more and more integral personality and with a wide vision of the world in that today one is living it is an unavoidable task to have the Cuban educators before yes, in a time characterized by a deep integration of the sciences. The achievement of this implies the elaboration of actions guided to reach a bigger integration among the contents of the subjects that today in day is imparted in the curriculum of the university students and its utility in the practice. For this aim it has decided to conceive the present work, with more emphasis in the interdisciplinarity among the subjects that are imparted in the disciplines History and Cultural Thought and Cuban Culture, corresponding to the Plan D of the career of Degree in Sociocultural Studies, being the main objective of the same one to favour the integration of the contents of this matters through the elaboration of a system of actions, demand of the current Cuban education without which we cannot perfect the teaching process - learning forming a man with a bigger preparation for the life, demand of the current Cuban society. The practical experiences applied in the University of The Tunas and the obtained results justify this proposal.

  19. Delineation of structures favourable to groundwater occurrence employing seismic refraction method — A case study from Tiruvuru, Krishna district, Andhra Pradesh

    Indian Academy of Sciences (India)

    N Sundararajan; Y Srinivas; M Narasimha Chary; G Nandakumar; A Hanmantha Chary

    2004-09-01

    The contacts associated with an outlier in biotite gneiss and sandstones near Tiruvuru, Krishna district, Andhra Pradesh which are generally favourable for groundwater occurrence were investigated employing refraction seismic method. Results were examined by correlating the signals with local geology, bore well data and other available information in order to improve the reliability of interpretation.

  20. Dental workforce development as part of the oral health agenda for Brunei Darussalam.

    Science.gov (United States)

    Wilson, Nairn H F; Shamshir, Z Abidin; Moris, Sylviana; Slater, Mabel; Kok, Ei Chuen; Dunne, Stephen M; Said, Samsiah H M; Lee, James M K; Gallagher, Jennifer E

    2013-02-01

    Brunei Darussalam is a Sultanate with a Malay Islamic monarchy. There are high levels of dental disease among its 406,200 population. The population's oral health needs require an integrated blend of primary and specialist care, together with oral health promotion. This paper describes the planning and measures taken to address these needs. In accordance with an oral health agenda published and launched in 2008, focusing on access, health promotion and prevention, and the education and training of the dental workforce, the Brunei Darussalam Ministry of Health is seeking to improve oral health status and reduce the burden of oral disease. It also seeks to transform the country's oral health services into a preventatively orientated, high-quality, seamless service underpinned by the concept of 'teeth for life'. In the process of effecting this transition, the Brunei Darussalam Ministry of Health is developing a dental workforce fit for future purpose, with an emphasis on a modern approach to skill mix. An important element of this programme has been the development of a highly successful Brunei Darussalam Diploma in Dental Therapy and Dental Hygiene. It is concluded that the Brunei Darussalam oral health agenda and, in particular, the forward-looking programme of dental workforce development is a model for other countries facing similar oral health challenges. © 2013 FDI World Dental Federation.

  1. Late Miocene fossils from shallow marine sediments in Brunei Darussalam: systematics, palaeoenvironment and ecology.

    Science.gov (United States)

    Roslim, Amajida; Briguglio, Antonino; Kocsis, László; Ćorić, Stjepan; Razak, Hazirah

    2016-04-01

    The geology of Brunei Darussalam is fascinating but difficult to approach: rainforests and heavy precipitation tend to erode and smoothen the landscape limiting rocks exposure, whereas abundant constructions sites and active quarries allow the creation of short time available outcrop, which have to be immediately sampled. The stratigraphy of Brunei Darussalam comprises mainly Neogene sediments deposited in a wave to tide dominated shallow marine environment in a pure siliciclastic system. Thick and heavily bioturbated sandstone layers alternate to claystone beds which occasionally yield an extraordinary abundance and diversity of fossils. The sandstones, when not bioturbated, are commonly characterized by a large variety of sedimentary structures (e.g., ripple marks, planar laminations and cross beddings). In this study, we investigate the sediments and the fossil assemblages to record the palaeoenvironmental evolution of the shallow marine environment during the late Miocene, in terms of sea level change, chemostratigraphy and sedimentation rate. The study area is one of the best in terms of accessibility, extension, abundance and preservation of fossils; it is located in the region -'Bukit Ambug' (Ambug Hill), Tutong District. The fossils fauna collected encompasses mollusks, decapods, otoliths, shark and ray teeth, amber, foraminifera and coccolithophorids. In this investigation, sediment samples were taken along a section which measures 62.5 meters. A thick clay layer of 9 meters was sampled each 30 cm to investigate microfossils occurrences. Each sample was treated in peroxide and then sieved trough 63 μm, 150μm, 250μm, 450μm, 600μm, 1mm and 2mm sieves. Results point on the changes in biodiversity of foraminifera along the different horizons collected reflecting sea level changes and sediment production. The most abundant taxa identified are Pseoudorotalia schroeteriana, Ampistegina lessonii, Elphidium advenum, Quinqueloculina sp., Bolivina sp

  2. Hillslope hydrology in tropical rainforest steeplands in Brunei

    Science.gov (United States)

    Dykes, A. P.; Thornes, J. B.

    2000-02-01

    Many remaining areas of tropical rainforest in south-east Asia are located on landscapes dominated by deep valleys and very steep slopes. Now that logging activities are extending into these steeplands, it is essential to understand how the natural rainforest system behaves if any kind of realistic assessment of the effects of such disturbance is to be made. This paper examines the hydrological behaviour of an undisturbed rainforest system on steep topography in the Temburong District of Brunei, north-west Borneo. The physical and hydrological properties of the regolith material are generally typical of tropical residual soils. The regolith has a clay texture and a low dry bulk density beneath a superficial litter/organic horizon. The infiltration capacity of the surface soil was several hundred mm h-1. That of the exposed mineral subsoil was an order of magnitude less, similar to the saturated hydraulic conductivity (Ksat) of around 180 mm h-1 at a depth of 150 cm. There was no indication that Ksat reduced with depth except very near the bedrock interface.Soil tensions were measured using a two-dimensional array of tensiometers on a 30° slope. During dry season conditions, infiltrating rain-water contributes to soil moisture, and drying of the soil is dominated by transpiration losses. During wet season conditions, perched water tables quickly develop during heavy rainfall, giving rise to the rapid production of return flow in ephemeral channels. No infiltration excess or saturation overland flow was observed on hillslopes away from channel margins. Subsurface storm flow combined with return flow produce stream flow hydrographs with high peak discharges and very short lag times. Storm event runoff coefficients are estimated to be as high as 40%. It is concluded that the most distinctive feature of the hydrology of this steepland rainforest is the extremely flashy nature of the catchment runoff regime produced by the combination of thin but very permeable regolith

  3. Primar y biliar y cirrhosis in Brunei Darussalam

    Institute of Scientific and Technical Information of China (English)

    Vui Heng Chong; Pemasiri Upali Telisinghe; Anand Jalihal

    2010-01-01

    BACKGROUND: Primary biliary cirrhosis (PBC) is an uncom-mon autoimmune cholestatic disease that predominantly affects women. Certain human leukocyte antigens (HLAs) have been reported to be associated with susceptibility for PBC. We describe the proifles of PBC in Brunei Darussalam. METHODS: All patients with PBC (n=10) were identiifed from our prospective databases. The HLA proifles (n=9, PBC) were compared to controls (n=65) and patients with autoimmune hepatitis (n=13, AIH). RESULTS: All patients were women with a median age of 51 years (27-83) at diagnosis. The prevalence rate of the disease was 25.6/million-population and the estimated incidence rate varied from 0 to 10.3/million-population per year. Chinese (41.15/million) and the indigenous (42.74/million) groups had higher prevalence rates compared to Malays (22.62/million). The prevalence among female population was 54.6/million-population. All patients were referred for abnormal liver proifles. Five patients had symptoms at presentations:jaundice (20%), fatigue (20%), arthralgia (30%) and pruritus (20%). Serum anti-mitochondrial antibody was positive in 80%of the patients. Overlap with AIH was seen in 30%. Liver biopsies (n=8) showed stage I (n=2), II (n=4) and III (n=2) ifbrosis. There were no signiifcant differences in the HLA proifles between PBC and AIH. Compared to the controls, PBC patients had signiifcantly more HLA class I alleles speciifcally B7 (P=0.003), Cw7 (P=0.002) and Cw12 (P=0.007) but not the class II alleles. At a median follow-up of 23.5 months (2 to 108), all patients were alive without evidence of disease progression. CONCLUSIONS: PBC is also a predominant female disorder in our local setting and most had mild disease. The HLA proifles of our patients were different to what have been reported.

  4. Pore water chemistry in a disturbed and an undisturbed peat forests in Brunei Darussalam: Nutrient and carbon contents

    Science.gov (United States)

    Gandois, L.; Cobb, A.; Abu Salim, K.; Chieng Hei, I.; Lim Biaw Leng, L.; Corlett, R.; Harvey, C.

    2010-12-01

    Tropical peat swamp forests in their natural state are important reservoir of biodiversity, carbon and water. However, they are rapidly vanishing due to agricultural conversion (mainly to oil palms), logging, drainage and fire. Peat swamp forests constitute an important contribution to global and regional biodiversity, providing an habitat to rare and threatened species. They encompass a sequence of forest types from the perimeter to the center of mildely elevated domes, and at our site in Brunei, are host to Shorea Albida trees (Anderson, 1983). They constitute a large terrestrial carbon reservoir (tropical peat soils contain up to 70 Pg C, which accounts for 20% of global peat soil carbon and 2% of the global soil carbon (Hirano et al., 2007)). In tropical peat swamp forests, the most important factors controling organic matter accumulation, as well as the biodiversity and structure of the forest, are hydrology and nutrients availability (Page et al., 1999). Study of pore water in peat swamp forest can provide key information on carbon cycle, including biomass production, organic matter decomposition and leaching of carbon in draining water. However, data on pore water chemistry and nutrient concentrations in pristine tropical peatlands, as well as the effect of forest exploitation are scarce. The study area is located in the Belait district in Brunei Darussalam in Borneo Island. Brunei is perhaps the best of the regional guardians of peat forest systems; potentially irreversible damage to peat forest ecosystems has been widespread elsewhere. Two sites, one pristine dome and a logging concession, are being investigated. In order to assess the chemical status of the peat soil, pore water is sampled at different depth along the dome radius. The chemistry of pore water, including pH, conductivity, dissolved oxygen, concentration of major elements, as well as organic carbon content and properties are analyzed. References: Anderson, 1983. The tropical peat swamp of

  5. Micro-caddisflies in the tribe Hydroptilini (Trichoptera: Hydroptilidae: Hydroptilinae) from Malaysia and Brunei

    NARCIS (Netherlands)

    Wells, A.; Huisman, J.

    1992-01-01

    Twenty-two new species of Hydroptilidae in six genera are described from Malaysia and Brunei: Ugandatrichia Mosely (1), Macrostactobia Schmid (1), Hydroptila Dalman (16), Oxyethira Eaton (1), and Hellyethira Neboiss (3). In addition, new distributional records of previously described species of Ugan

  6. Extreme differences in forest degradation in Borneo: comparing practices in Sarawak, Sabah, and Brunei.

    Directory of Open Access Journals (Sweden)

    Jane E Bryan

    Full Text Available The Malaysian states of Sabah and Sarawak are global hotspots of forest loss and degradation due to timber and oil palm industries; however, the rates and patterns of change have remained poorly measured by conventional field or satellite approaches. Using 30 m resolution optical imagery acquired since 1990, forest cover and logging roads were mapped throughout Malaysian Borneo and Brunei using the Carnegie Landsat Analysis System. We uncovered ∼364,000 km of roads constructed through the forests of this region. We estimated that in 2009 there were at most 45,400 km(2 of intact forest ecosystems in Malaysian Borneo and Brunei. Critically, we found that nearly 80% of the land surface of Sabah and Sarawak was impacted by previously undocumented, high-impact logging or clearing operations from 1990 to 2009. This contrasted strongly with neighbouring Brunei, where 54% of the land area remained covered by unlogged forest. Overall, only 8% and 3% of land area in Sabah and Sarawak, respectively, was covered by intact forests under designated protected areas. Our assessment shows that very few forest ecosystems remain intact in Sabah or Sarawak, but that Brunei, by largely excluding industrial logging from its borders, has been comparatively successful in protecting its forests.

  7. Extreme differences in forest degradation in Borneo: comparing practices in Sarawak, Sabah, and Brunei.

    Science.gov (United States)

    Bryan, Jane E; Shearman, Philip L; Asner, Gregory P; Knapp, David E; Aoro, Geraldine; Lokes, Barbara

    2013-01-01

    The Malaysian states of Sabah and Sarawak are global hotspots of forest loss and degradation due to timber and oil palm industries; however, the rates and patterns of change have remained poorly measured by conventional field or satellite approaches. Using 30 m resolution optical imagery acquired since 1990, forest cover and logging roads were mapped throughout Malaysian Borneo and Brunei using the Carnegie Landsat Analysis System. We uncovered ∼364,000 km of roads constructed through the forests of this region. We estimated that in 2009 there were at most 45,400 km(2) of intact forest ecosystems in Malaysian Borneo and Brunei. Critically, we found that nearly 80% of the land surface of Sabah and Sarawak was impacted by previously undocumented, high-impact logging or clearing operations from 1990 to 2009. This contrasted strongly with neighbouring Brunei, where 54% of the land area remained covered by unlogged forest. Overall, only 8% and 3% of land area in Sabah and Sarawak, respectively, was covered by intact forests under designated protected areas. Our assessment shows that very few forest ecosystems remain intact in Sabah or Sarawak, but that Brunei, by largely excluding industrial logging from its borders, has been comparatively successful in protecting its forests.

  8. Prediction of employer-employee relationships from sociodemographic variables and social values in Brunei public and private sector workers.

    Science.gov (United States)

    Mundia, Lawrence; Mahalle, Salwa; Matzin, Rohani; Nasir Zakaria, Gamal Abdul; Abdullah, Nor Zaiham Midawati; Abdul Latif, Siti Norhedayah

    2017-01-01

    The purpose of the study was to identify the sociodemographic variables and social value correlates and predictors of employer-employee relationship problems in a random sample of 860 Brunei public and private sector workers of both genders. A quantitative field survey design was used and data were analyzed by correlation and logistic regression. The rationale and justification for using this approach is explained. The main sociodemographic correlates and predictors of employer-employee relationship problems in this study were educational level and the district in which the employee resided and worked. Other correlates, but not necessarily predictors, of employer-employee relationship problems were seeking help from the Bomo (traditional healer); obtaining help from online social networking; and workers with children in the family. The two best and most significant social value correlates and predictors of employer-employee relationship problems included interpersonal communications; and self-regulation and self-direction. Low scorers on the following variables were also associated with high likelihood for possessing employer-employee relationship problems: satisfaction with work achievements; and peace and security, while low scorers on work stress had lower odds of having employer-employee relationship problems. Other significant social value correlates, but not predictors of employer-employee relationship problems were self-presentation; interpersonal trust; peace and security; and general anxiety. Consistent with findings of relevant previous studies conducted elsewhere, there were the variables that correlated with and predicted employer-employee relationship problems in Brunei public and private sector workers. Having identified these, the next step, efforts and priority should be directed at addressing the presenting issues via counseling and psychotherapy with affected employees. Further research is recommended to understand better the problem and its

  9. Prediction of employer–employee relationships from sociodemographic variables and social values in Brunei public and private sector workers

    Science.gov (United States)

    Mundia, Lawrence; Mahalle, Salwa; Matzin, Rohani; Nasir Zakaria, Gamal Abdul; Abdullah, Nor Zaiham Midawati; Abdul Latif, Siti Norhedayah

    2017-01-01

    The purpose of the study was to identify the sociodemographic variables and social value correlates and predictors of employer–employee relationship problems in a random sample of 860 Brunei public and private sector workers of both genders. A quantitative field survey design was used and data were analyzed by correlation and logistic regression. The rationale and justification for using this approach is explained. The main sociodemographic correlates and predictors of employer–employee relationship problems in this study were educational level and the district in which the employee resided and worked. Other correlates, but not necessarily predictors, of employer–employee relationship problems were seeking help from the Bomo (traditional healer); obtaining help from online social networking; and workers with children in the family. The two best and most significant social value correlates and predictors of employer–employee relationship problems included interpersonal communications; and self-regulation and self-direction. Low scorers on the following variables were also associated with high likelihood for possessing employer–employee relationship problems: satisfaction with work achievements; and peace and security, while low scorers on work stress had lower odds of having employer–employee relationship problems. Other significant social value correlates, but not predictors of employer–employee relationship problems were self-presentation; interpersonal trust; peace and security; and general anxiety. Consistent with findings of relevant previous studies conducted elsewhere, there were the variables that correlated with and predicted employer–employee relationship problems in Brunei public and private sector workers. Having identified these, the next step, efforts and priority should be directed at addressing the presenting issues via counseling and psychotherapy with affected employees. Further research is recommended to understand better the

  10. RESPIRATORY SYMPTOMS OF VENDORS IN AN OPEN AIR HAWKER CENTRE IN BRUNEI DARUSSALAM

    Directory of Open Access Journals (Sweden)

    Nurul Nor Nazurah ebt Abdul Wahid

    2014-10-01

    Full Text Available ObjectivesWe studied respiratory problems among vendors exposed to cooking fumes in an open-air hawker centre. Exposure to cooking fumes from either the use of fossil fuels or liquefied petroleum gas (LPG has been shown to be associated with adverse respiratory health effects.Methods We conducted a cross-sectional study among 67 food vendors exposed to cooking fumes as well as 18 merchandise sellers at an open-air hawker centre in Brunei Darussalam. Past medical and smoking history and exposure to cooking fumes were obtained. The validated American Thoracic Society (ATS Questionnaire with a translated Malay version was used to ask for respiratory symptoms. Results Compared to merchandise sellers (n=18, cooking vendors (n=67 had a higher self-reported respiratory symptoms (50.7% for those cooking and 33.3% for merchandise sellers. Cough (28.3% was the main respiratory symptom experienced in cooking vendors and breathlessness (22.2% among merchandise sellers. Half (50.0% of cooking vendors who worked for more than 10 years had cough and 27.3% had phlegm. Those cooking with charcoal were two times more likely to have cough than those cooking with LPG. Cooking vendors with a job duration of more than 10 years were thrice more likely to have cough.Conclusion Cooking vendors in the open air hawker centre exposed to cooking fumes had more respiratory symptoms compared to non-exposed merchandise sellers. The type of fuel used for cooking and duration of work were associated with increased prevalence of cough.

  11. Ichneumon wasp back in favour

    NARCIS (Netherlands)

    Sikkema, A.; Ramakers, P.M.J.

    2010-01-01

    The Aphidius matricariae wasp of the Ichneumon family was widely used to get rid of plant lice in greenhouse agriculture up to fifteen years ago. Since then, it has given way to its American cousin, Aphidius colemani. A comparative study by the Wageningen UR Greenhouse Horticulture group has led to

  12. Role of occupational health in managing non-communicable diseases in Brunei Darussalam

    Directory of Open Access Journals (Sweden)

    Pg Khalifah Pg Ismail

    2014-11-01

    Full Text Available Like most ASEAN countries, Brunei faces an epidemic of non-communicable diseases. To deal with the complexity of NCDs prevention, all perspectives - be it social, familial or occupational – need to be considered. In Brunei Darussalam, occupational health services (OHS offered by its Ministry of Health, among others, provide screening and management of NCDs at various points of service. The OHS does not only issue fitness to work certificates, but is a significant partner in co-managing patients’ health conditions, with the advantage of further management at the workplace. Holistic approach of NCD management in the occupational setting is strengthened with both employer and employee education and participation, targeting several approaches including risk management and advocating healthy lifestyles as part of a healthy workplace programme.

  13. Genetic stock compositions and natal origin of green turtle (Chelonia mydas foraging at Brunei Bay

    Directory of Open Access Journals (Sweden)

    Juanita Joseph

    2016-04-01

    Full Text Available Knowledge of genetics composition and growth stages of endangered green turtles, as well as the connectivity between nesting and foraging grounds is important for effective conservation. A total of 42 green turtles were captured at Brunei Bay with curved carapace length ranging from 43.8 to 102.0 cm, and most sampled individuals were adults and large juveniles. Twelve haplotypes were revealed in mitochondrial DNA control region sequences. Most haplotypes contained identical sequences to haplotypes previously found in rookeries in the Western Pacific, Southeast Asia, and the Indian Ocean. Haplotype and nucleotide diversity indices of the Brunei Bay were 0.8444±0.0390 and 0.009350±0.004964, respectively. Mixed-stock analysis (for both uninformative and informative prior weighting by population size estimated the main contribution from the Southeast Asian rookeries of the Sulu Sea (mean ≥45.31%, Peninsular Malaysia (mean ≥17.42%, and Sarawak (mean ≥12.46%. Particularly, contribution from the Sulu Sea rookery was estimated to be the highest and lower confidence intervals were more than zero (≥24.36%. When estimating contributions by region rather than individual rookeries, results showed that Brunei Bay was sourced mainly from the Southeast Asian rookeries. The results suggest an ontogenetic shift in foraging grounds and provide conservation implications for Southeast Asian green turtles.

  14. Environmental adversity and uncertainty favour cooperation

    Science.gov (United States)

    Andras, Peter; Lazarus, John; Roberts, Gilbert

    2007-01-01

    Background A major cornerstone of evolutionary biology theory is the explanation of the emergence of cooperation in communities of selfish individuals. There is an unexplained tendency in the plant and animal world – with examples from alpine plants, worms, fish, mole-rats, monkeys and humans – for cooperation to flourish where the environment is more adverse (harsher) or more unpredictable. Results Using mathematical arguments and computer simulations we show that in more adverse environments individuals perceive their resources to be more unpredictable, and that this unpredictability favours cooperation. First we show analytically that in a more adverse environment the individual experiences greater perceived uncertainty. Second we show through a simulation study that more perceived uncertainty implies higher level of cooperation in communities of selfish individuals. Conclusion This study captures the essential features of the natural examples: the positive impact of resource adversity or uncertainty on cooperation. These newly discovered connections between environmental adversity, uncertainty and cooperation help to explain the emergence and evolution of cooperation in animal and human societies. PMID:18053138

  15. Environmental adversity and uncertainty favour cooperation

    Directory of Open Access Journals (Sweden)

    Lazarus John

    2007-11-01

    Full Text Available Abstract Background A major cornerstone of evolutionary biology theory is the explanation of the emergence of cooperation in communities of selfish individuals. There is an unexplained tendency in the plant and animal world – with examples from alpine plants, worms, fish, mole-rats, monkeys and humans – for cooperation to flourish where the environment is more adverse (harsher or more unpredictable. Results Using mathematical arguments and computer simulations we show that in more adverse environments individuals perceive their resources to be more unpredictable, and that this unpredictability favours cooperation. First we show analytically that in a more adverse environment the individual experiences greater perceived uncertainty. Second we show through a simulation study that more perceived uncertainty implies higher level of cooperation in communities of selfish individuals. Conclusion This study captures the essential features of the natural examples: the positive impact of resource adversity or uncertainty on cooperation. These newly discovered connections between environmental adversity, uncertainty and cooperation help to explain the emergence and evolution of cooperation in animal and human societies.

  16. Iodixanol Has a Favourable Fibrinolytic Profile Compared to Iohexol in Cardiac Patients Undergoing Elective Angiography: A Double-Blind, Randomized, Parallel Group Study.

    Directory of Open Access Journals (Sweden)

    Andrew T Treweeke

    Full Text Available There is no consensus and a limited evidence base for choice of contrast agents (CA in angiography. This study evaluated the impact of iohexol and iodixanol CA on fibrinolytic factors (tissue plasminogen activator [t-PA] and plasminogen activator inhibitor-1 [PAI-1], as well as platelet-monocyte conjugates in cardiac patients undergoing elective angiography in a double-blind, randomised parallel group study.Patients (men, 50-70 years old; n = 12 were randomised to receive either iohexol (Omnipaque; n = 6 or iodixanol (Visipaque; n = 6 during elective angiography at Raigmore Hospital, Inverness, UK. Arterial and venous blood samples were drawn prior to CA delivery and following angiography. Assessment of platelet-monocyte conjugation, t-PA and PAI-1 antigen and activity was conducted in samples pre- and post-angiography.Plasma t-PA antigen was depressed equally in the study groups after angiography, but there was a greater reduction in PAI-1 antigen in the group receiving iodixanol. These findings corresponded to a substantial reduction in t-PA activity in patients receiving iohexol, with no change in those receiving iodixanol (P = 0.023 between the CA groups. Both CAs caused a reduction in platelet-monocyte conjugation, with no difference between the groups. No adverse events were reported during the trial.Avoiding reduced plasma t-PA activity might be an important consideration in choosing iodixanol over iohexol in patients at risk of thrombosis following angiography. The trial is registered on the ISRCTN register (ISRCTN51509735 and funded by the Coronary Thrombosis Trust and National Health Service (Highland R&D Endowments. The funders had no influence over study design or reporting.Controlled-Trials.com ISRCTN51509735.

  17. The diversity and abundance of ground herbs in lowland mixed dipterocarp forest and heath forest in Brunei Darussalam

    Directory of Open Access Journals (Sweden)

    Nurul Hazlina Zaini

    2014-12-01

    Full Text Available Herbaceous plants are important components of total plant species richness in tropical forests. Ground herb diversity and abundance were studied in a lowland Mixed Dipterocarp forest (Andulau and a heath forest (Bukit Sawat in Brunei Darussalam, Borneo. At each site, all ground herbs in twenty randomly selected 10 × 10 m subplots within a one hectare permanent plot were censused and identified. The study recorded a total of 20 families and 32 genera of ground herbs, with the family Zingiberaceae as the most abundant at both sites. Thirteen genera were recorded only at Andulau and 7 genera were exclusive to Bukit Sawat, with twelve genera common to both sites. Ground herb species richness appear higher at Andulau than Bukit Sawat (37 vs. 29, but this difference was not statistically significant at the subplot level. However, ground herb abundance and density were significantly higher at Bukit Sawat than Andulau (n =  846 vs. 385; 4230 vs. 1925 individuals ha-1. The more open canopy at Bukit Sawat may provide higher light availability here than at Andulau, which is characterised by a closed canopy. We suggest that light availability is the most important environmental factor influencing ground herb density and abundance at these sites. 

  18. Evidence in Favour of IMF Variations

    OpenAIRE

    Eisenhauer, Frank

    2001-01-01

    The stellar initial mass function (IMF) determines the relative number of stars born at a given mass. Despite the tremendous effort to establish a universal IMF, the astronomical literature offers a wealth of diverse evidence for IMF variations. This review was prepared for a controversial debate at the conference ``Starbursts -- Near and Far'' at Ringberg Castle, 2000, and gives a one-sided portrayal in favour of IMF variations. I will summarise the empirical evidence that the IMF varies wit...

  19. Comparison of Brunei Preservice Student Teachers' Attitudes to Inclusive Education and Specific Disabilities: Implications for Teacher Education

    Science.gov (United States)

    Haq, Faridah Serajul; Mundia, Lawrence

    2012-01-01

    The authors investigated and compared Brunei trainee teachers' attitudes to specific disabilities and students with high support needs. The random sample consisted of 89 participants of both genders on 2 teacher education programs. Data were collected using a 3-part self-report instrument constructed by the researchers. Overall, the participants…

  20. The mushroom coral fauna (Scleractinia: Fungiidae) of Brunei Darussalam (South China Sea) and its relation to the Coral Triangle

    NARCIS (Netherlands)

    Hoeksema, B.W.; Lane, D.J.W.

    2014-01-01

    Brunei Darussalam is situated on the northwest coast of Borneo, just outside the westernmost boundary of the area presently recognised as the centre of maximum marine biodiversity, the so-called Coral Triangle. This diversity is particularly quantified with regard to numbers of reef coral species.

  1. The mushroom coral fauna (Scleractinia: Fungiidae) of Brunei Darussalam (South China Sea) and its relation to the Coral Triangle

    NARCIS (Netherlands)

    Hoeksema, B.W.; Lane, D.J.W.

    2014-01-01

    Brunei Darussalam is situated on the northwest coast of Borneo, just outside the westernmost boundary of the area presently recognised as the centre of maximum marine biodiversity, the so-called Coral Triangle. This diversity is particularly quantified with regard to numbers of reef coral species. M

  2. China-ASEAN Association President Gu Xiulian Visits Myanmar,Indonesia and Brunei and Attends Second Conference on China-ASEAN People-to-People Friendship Organizations

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    <正>At the invitation of the Union Solidarity and Development Association of Myanmar (USDA), the Association of Indonesia-China Economic, Social and Cultural Cooperation (AICESCC) and the Brunei-China Friendship Association (BCFA), Gu Xiulian, president of the China-ASEAN Association and vice chairperson of the Standing Committee of the National People’s Congress, led a delegation of the China-ASEAN Association to pay a goodwill visit to Myanmar, Indonesia and Brunei from June 10 to 21 and attended the Second Conference on China-ASEAN People-to-People Friendship Organizations in Bandar Seri Begawan, Brunei.

  3. Sociodemographic variables and social values: relationship with work-attendance problems in Brunei public- and private-sector employees.

    Science.gov (United States)

    Mundia, Lawrence; Mahalle, Salwa; Matzin, Rohani; Zakaria, Gamal Abdul Nasir; Abdullah, Nor Zaiham Midawati

    2017-01-01

    The study investigated the degree to which selected sociodemographic variables and social values were related to work-attendance problems in a random sample of 860 Brunei public- and private-sector employees and the nature of this relationship. This quantitative study used the field-survey approach to administer research instruments directly to participants. This enabled the researchers to help participants who needed assistance in completing the measures properly, so as to increase the number of usable returns. Two sociodemographic variables (seeking help from a counselor/psychologist and marital status) correlated significantly with work attendance. Private-sector employees were more likely to have work-attendance problems than government workers. Both single and married employees and the chief wage earner in the household were more likely to have work-attendance issues to deal with compared to their counterparts. However, employees who sought help from a counselor/psychologist were far less likely to have work-attendance problems compared to those who did not get such help. The most significant social-value correlates with work-attendance problems were interpersonal communication, employer-employee relationship, work-stress problems, self-presentation, self-regulation, self-direction, and interpersonal trust. Self-regulation, self-direction, and satisfaction with work-related achievements significantly predicted work-attendance problems positively, while interpersonal communication problems and work-stress problems predicted work-attendance problems negatively. Low scorers on self-regulation and self-direction, as well as on satisfaction with work-related achievements, were more likely to have work-attendance problems compared to high scorers. However, low scorers on interpersonal communication and work-stress problems were less likely to have work-attendance problems compared to high-scoring peers. Ample evidence from this study showed that sociodemographic

  4. Multidrug-resistant Acinetobactor baumannii isolated from a traveler returned from Brunei.

    Science.gov (United States)

    Tojo, Masayoshi; Mawatari, Momoko; Hayakawa, Kayoko; Nagamatsu, Maki; Shimada, Kayo; Mezaki, Kazuhisa; Sugiki, Yuko; Kuroda, Emi; Takeshita, Nozomi; Kutsuna, Satoshi; Fujiya, Yoshihiro; Miyoshi-Akiyama, Tohru; Kirikae, Teruo; Ohmagari, Norio

    2015-03-01

    We report a case of multidrug-resistant (MDR) Acinetobactor baumannii isolates obtained from a traveler returned from Brunei. Whole-genome sequencing analysis revealed that the isolates harbored blaOxA-23 and armA. The minimum inhibitory concentrations of antibiotics against the strain were as follows: imipenem, 32 μg/ml; meropenem, 32 μg/ml; ciprofloxacin, 16 μg/ml; amikacin, ≧ 1024 μg/ml; arbekacin, ≧ 1024 μg/ml; aztreonam, 64 μg/ml; colistin, 4 μg/ml. A. baumannii harboring both blaOxA-23 and armA is rarely reported in Japan, and, to the best of our knowledge, this is the second report of A. baumannii harboring both resistant genes in Japan. Copyright © 2014. Published by Elsevier Ltd.

  5. Observational evidence favours a static universe

    CERN Document Server

    Crawford, David F

    2010-01-01

    The common attribute of all Big Bang cosmologies is that they are based on the assumption that the universe is expanding. However examination of the evidence for this expansion clearly favours a static universe. The major topics considered are: Tolman surface brightness, angular size, type 1a supernovae, gamma ray bursts, galaxy distributions, quasar distributions, X-ray background radiation, cosmic microwave background radiation, radio source counts, quasar variability and the Butcher--Oemler effect. An analysis of the best raw data for these topics shows that they are consistent with expansion only if there is evolution that cancels the effects of expansion. An alternate cosmology, curvature cosmology, is in full agreement with the raw data. This tired-light cosmology predicts a well defined static and stable universe and is fully described. It not only predicts accurate values for the Hubble constant and the temperature of cosmic microwave background radiation but shows excellent agreement with most of the...

  6. Effects of termite activities on coarse woody debris decomposition in an intact lowland mixed dipterocarp forest of Brunei Darussalam

    Science.gov (United States)

    Lee, S.; Kim, S.; Roh, Y.; Son, Y.

    2016-12-01

    Tropical forests play a critical role in mitigating climate change, because they sequester carbon more than any other terrestrial ecosystems. In addition, coarse woody debris is one of the main carbon storages, accounting for 10 - 40% of the tropical forest carbon. Carbon in coarse woody debris is released by various activities of organisms, and particularly termite's feeding activities are known to be a main process in tropical forests. Therefore, investigating the effects of termite activities on coarse woody debris decomposition is important to understanding carbon cycles of tropical forests. This study was conducted in an intact lowland mixed dipterocarp forest (MDF) of Brunei Darussalam, and three main MDF tree species (Dillenia beccariana, Macaranga bancana, and Elateriospermum tapos) were selected. Coarse woody debris samples of both 10 cm diameter and length were prepared, and half of samples were covered twice with nylon net (mesh size 1.5 mm × 1.5 mm) to prevent termite's approach. Three permanent plots were installed in January, 2015 and 36 samples per plot (3 species × 2 treatments × 6 replicates) were placed at the soil surface. Weights of each sample were recorded at initial time, and weighed again at an interval of 6 months until July, 2016. On average, uncovered and covered samples lost 32.4 % and 20.0 % of their initial weights, respectively. Weight loss percentage was highest in uncovered samples of M. bancana (43.8 %), and lowest in covered samples of E. tapos (14.7 %). Two-way ANOVA showed that the effects of the tree species and the termite exclusion treatment on coarse woody debris decomposition were statistically significant (P Education Center.

  7. Approach to voxel-based carbon stock quanticiation using LiDAR data in tropical rainforest, Brunei

    Science.gov (United States)

    Kim, Eunji; Piao, Dongfan; Lee, Jongyeol; Lee, Woo-Kyun; Yoon, Mihae; Moon, Jooyeon

    2016-04-01

    Forest is an important means to adapt climate change as the only carbon sink recognized by the international community (KFS 2009). According to the Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Report (AR5), Agriculture, Forestry, and Other Land Use (AFOLU) sectors including forestry contributed 24% of total anthropogenic emissions in 2010 (IPCC 2014; Tubiello et al. 2015). While all sectors excluding AFOLU have increased Greenhouse Gas (GHG) emissions, land use sectors including forestry remains similar level as before due to decreasing deforestation and increasing reforestation. In earlier researches, optical imagery has been applied for analysis (Jakubowski et al. 2013). Optical imagery collects spectral information in 2D. It is difficult to effectively quantify forest stocks, especially in dense forest (Cui et al. 2012). To detect individual trees information from remotely sensed data, Light detection and ranging (LiDAR) has been used (Hyyppäet al. 2001; Persson et al. 2002; Chen et al. 2006). Moreover, LiDAR has the ability to actively acquire vertical tree information such as tree height using geo-registered 3D points (Kwak et al. 2007). In general, however, geo-register 3D point was used with a raster format which contains only 2D information by missing all the 3D data. Therefore, this research aimed to use the volumetric pixel (referred as "voxel") approach using LiDAR data in tropical rainforest, Brunei. By comparing the parameters derived from voxel based LiDAR data and field measured data, we examined the relationships between them for the quantification of forest carbon. This study expects to be more helpful to take advantage of the strategic application of climate change adaption.

  8. Effects of termite activities on coarse woody debris decomposition in an intact lowland mixed dipterocarp forest of Brunei Darussalam

    Science.gov (United States)

    Lee, Sohye; Kim, Seungjun; Roh, Yujin; Abu Salim, Kamariah; Lee, Woo-Kyun; Davies, Stuart; Son, Yowhan

    2016-04-01

    Tropical forests have been considered important ecosystems in terms of carbon cycle and climate change, because they sequester carbon more than any other terrestrial ecosystems. In addition, coarse woody debris is one of the main carbon storages, accounting for 10 - 40% of the tropical forest carbon. Carbon in coarse woody debris is released by various activities of organisms, and particularly termite's feeding activities are known to be main process in tropical forests. Therefore, investigating the effects of termite activities on coarse woody debris decomposition is important to understanding carbon cycles of tropical forests. This study was conducted in an intact lowland mixed dipterocarp forest (MDF) of Brunei Darussalam, and three main MDF tree species (Dillenia beccariana, Macaranga bancana, and Elateriospermum tapos) were selected. Coarse woody debris samples of both 10 cm diameter and length were prepared, and half of samples were covered twice with nylon net (mesh size 1.5 mm × 1.5 mm) to prevent termite's approach. Three 2 m × 11 m permanent plots were installed in January, 2015 and eighteen samples per plot (3 species × 2 treatments × 3 repetitions) were placed at the soil surface. Weights of each sample were recorded at initial time, and weighed again in August, 2015. On average, uncovered and covered samples lost 18.9 % and 3.3 % of their initial weights, respectively. Weight loss percentage was highest in uncovered samples of M. bancana (23.9 %), and lowest in covered samples of E. tapos (7.8 %). Two-way ANOVA showed that tree species and termite exclusion treatment had statistically significant effects on coarse woody debris decomposition (P = 0.0001). The effect of species and termite exclusion treatment interaction was also statistically significant (P = 0.0001). The result reveals that termite activities promote the coarse woody debris decomposition and they influence differently along the wood species. However, many samples of D. beccariana

  9. Determinants of favourable opinions about euthanasia in a sample of French physicians

    National Research Council Canada - National Science Library

    Dany, Lionel; Baumstarck, Karine; Dudoit, Eric; Duffaud, Florence; Auquier, Pascal; Salas, Sébastien

    2015-01-01

    .... The objective of this study in a sample of French physicians was to establish the potential determinants of a favourable opinion about euthanasia in general and when faced with a specific situation...

  10. Preliminary Study of Favourable Formations for CO{sub 2} Subsurface Storage in Spain; Estudio Preliminar de las Formaciones Favorables para el Almacenamiento Subterraneo de CO{sub 2} en Espana

    Energy Technology Data Exchange (ETDEWEB)

    Zapatero, M. A.; Reyes, J. L.; Martinez, R.; Suarez, I.; Arenillas, A.; Perucha, M. A.

    2009-10-12

    This report is a synthesis of the possibilities of CO{sub 2} storage in the Spanish subsurface. Compilation and analysis of geological information has been carried out, looking at surface and subsurface, in order to make a pre-selection of potential favourable units for CO{sub 2} storage, taking in account that each of this storages needs a confining formation to seal the storage. Before the storage selection, a general description of the great geological units of the Iberian Peninsula is done. Afterwards, borehole logging from petroleum exploration is analysed in these units, formations and areas of interest. The aim is to finally obtain a description of selected units and their possibilities of CO{sub 2} storage. (Author) 17 refs.

  11. Should Marketers Try to Change Consumers Unfavourable Attitude for their Product into Favourable?

    OpenAIRE

    Sunday O. E. Ewah; Patrick M. Igbaji; Christian I. Umeh

    2014-01-01

    This is an empirical study of the interplay between consumers' attitude toward marketers’ products and marketers; wish to elicit favourable buying behaviour from the consumer. According to the study the process of this transformation of consumer’s attitude is not quite easy. The marketers have to put their acts together by producing products to match consumers attitude or build a gradual change that will result to favourable buying decision from the consumer.

  12. Global warming favours light-coloured insects in Europe.

    Science.gov (United States)

    Zeuss, Dirk; Brandl, Roland; Brändle, Martin; Rahbek, Carsten; Brunzel, Stefan

    2014-05-27

    Associations between biological traits of animals and climate are well documented by physiological and local-scale studies. However, whether an ecophysiological phenomenon can affect large-scale biogeographical patterns of insects is largely unknown. Insects absorb energy from the sun to become mobile, and their colouration varies depending on the prevailing climate where they live. Here we show, using data of 473 European butterfly and dragonfly species, that dark-coloured insect species are favoured in cooler climates and light-coloured species in warmer climates. By comparing distribution maps of dragonflies from 1988 and 2006, we provide support for a mechanistic link between climate, functional traits and species that affects geographical distributions even at continental scales. Our results constitute a foundation for better forecasting the effect of climate change on many insect groups.

  13. Reported Experiences Enhance Favourable Attitudes toward Toads

    Science.gov (United States)

    Tomazic, Iztok

    2011-01-01

    There are many factors that influence the formation of attitudes, one of the most crucial ones being education. Positive attitudes toward animals can be effectively accomplished principally by enabling students to directly experience organisms and their environments. The following study presents the development of a Toad Attitude Questionnaire…

  14. Natural selection can favour 'irrational' behaviour

    OpenAIRE

    McNamara, J. M.; Trimmer, P. C.; Houston, A. I.

    2014-01-01

    Understanding decisions is the fundamental aim of the behavioural sciences. The theory of rational choice is based on axiomatic principles such as transitivity and independence of irrelevant alternatives (IIA). Empirical studies have demonstrated that the behaviour of humans and other animals often seems irrational; there can be a lack of transitivity in choice and seemingly irrelevant alternatives can alter decisions. These violations of transitivity and IIA undermine rational choice theory....

  15. Natural selection can favour 'irrational' behaviour.

    Science.gov (United States)

    McNamara, J M; Trimmer, P C; Houston, A I

    2014-01-01

    Understanding decisions is the fundamental aim of the behavioural sciences. The theory of rational choice is based on axiomatic principles such as transitivity and independence of irrelevant alternatives (IIA). Empirical studies have demonstrated that the behaviour of humans and other animals often seems irrational; there can be a lack of transitivity in choice and seemingly irrelevant alternatives can alter decisions. These violations of transitivity and IIA undermine rational choice theory. However, we show that an individual that is maximizing its rate of food gain can exhibit failure of transitivity and IIA. We show that such violations can be caused because a current option may disappear in the near future or a better option may reappear soon. Current food options can be indicative of food availability in the near future, and this key feature can result in apparently irrational behaviour.

  16. Code-Switching in the Primary Classroom: One Response to the Planned and the Unplanned Language Environment in Brunei [and] A Response.

    Science.gov (United States)

    Martin, Peter W.; Espiritu, Clemencia C

    1996-01-01

    Examines how the teacher incorporates elements of both "Bahasa Melayu" and Brunei Malay into content lessons and views code switching in the primary classroom within the wider framework of community language norms and the linguistic pressures on students and teachers. Espiritu shares Martin's concern regarding the quantity and quality of…

  17. Barriers to Mathematics Achievement in Brunei Secondary School Students: Insights into the Roles of Mathematics Anxiety, Self-Esteem, Proactive Coping, and Test Stress

    Science.gov (United States)

    Hamid, Malai Hayati Sheikh; Shahrill, Masitah; Matzin, Rohani; Mahalle, Salwa; Mundia, Lawrence

    2013-01-01

    The cross-sectional field survey examined the roles of mathematics anxiety, self-esteem, proactive coping, and test stress in mathematics achievement among 204 (151 females) randomly selected Year 8-10 Brunei secondary school students. The negative dimensions of mathematics anxiety, self-esteem, and proactive coping correlated negatively with…

  18. Mesophotic mushroom coral records at Brunei Darussalam support westward extension of the Coral Triangle to the South China Sea waters of Northwest Borneo

    NARCIS (Netherlands)

    Lane, D.J.W.; Hoeksema, B.W.

    2016-01-01

    This communication reports the discovery of two additional fungiid coral species, Cycloseris hexagonalis and Lithophyllon spinifer, from a relatively deep shelf reef in Brunei waters. These new records plus two earlier excluded ones, Cycloseris explanulata and C. wellsi, raise the known number of

  19. Code-Switching in the Primary Classroom: One Response to the Planned and the Unplanned Language Environment in Brunei [and] A Response.

    Science.gov (United States)

    Martin, Peter W.; Espiritu, Clemencia C

    1996-01-01

    Examines how the teacher incorporates elements of both "Bahasa Melayu" and Brunei Malay into content lessons and views code switching in the primary classroom within the wider framework of community language norms and the linguistic pressures on students and teachers. Espiritu shares Martin's concern regarding the quantity and quality of…

  20. Social Desirability, Non-Response Bias and Reliability in a Long Self-Report Measure: Illustrations from the MMPI-2 Administered to Brunei Student Teachers

    Science.gov (United States)

    Mundia, Lawrence

    2011-01-01

    The survey investigated the problems of social desirability (SD), non-response bias (NRB) and reliability in the Minnesota Multiphasic Personality Inventory--Revised (MMPI-2) self-report inventory administered to Brunei student teachers. Bruneians scored higher on all the validity scales than the normative US sample, thereby threatening the…

  1. Searching development strategies for less-favoured areas

    NARCIS (Netherlands)

    Ruben, R.; Kuiper, M.H.; Pender, J.

    2006-01-01

    Rural households in less-favoured areas (LFAs) face multiple constraints for overcoming chronic poverty and resource degradation. Strategic development options can be assessed through interdisciplinary research based on coupling of human and natural systems approaches. Simulation modelling enables t

  2. 对文莱能长期保持政治社会稳定的几点看法%My Views on Brunei's Long - term Perseverance of its Political and Social Stability

    Institute of Scientific and Technical Information of China (English)

    王云娇

    2005-01-01

    Brunei has its unique features in its politics and society. With this in view, this article tries, from the sociological perspective, to state some views on how it is able to sustain its stability in those two fields.

  3. The veil of ignorance can favour biological cooperation.

    Science.gov (United States)

    Queller, David C; Strassmann, Joan E

    2013-01-01

    Lack of information is a constraint but ignorance can sometimes assist the evolution of cooperation by constraining selfishness. We discuss examples involving both ignorance of role or pay-off and ignorance of relatedness. Ignorance can favour cooperative traits like grouping and warning coloration and reduce conflicts from meiotic drive, imprinting, greenbeards and various forms of nepotism.

  4. Arguments in favour of compulsory treatment of opioid dependence.

    Science.gov (United States)

    Wu, Zunyou

    2013-02-01

    Twelve agencies of the United Nations, including the World Health Organization, have issued a joint statement that calls on Member States to replace the compulsory detention of people who use opioids in treatment centres with voluntary, evidence-informed and rights-based health and social services. The arguments in favour of this position fall into three broad categories: Compulsory treatment centres infringe on an individual's liberty, they put human beings at risk of harm, and evidence of their effectiveness against opioid dependence has not been generated. The United Nations statement underscores that although countries apply different criteria for sending individuals to compulsory treatment centres, detention often takes place without due process, legal safeguards or judicial review. This clearly violates internationally recognized human rights standards. Furthermore, people who are committed to these centres are often exposed to physical and sexual violence, forced labour and sub-standard living conditions. They are often denied health care, despite their heightened vulnerability to HIV infection and tuberculosis. Finally, there is no evidence, according to the statement, that these centres offer an environment that is conducive to recovery from opioid dependence or to the rehabilitation of commercial sex workers or of children who have suffered sexual exploitation, abuse or lack of care and protection. The author of this paper sets forth several arguments that counter the position taken by the United Nations and argues in favour of compulsory treatment within a broader harm reduction strategy aimed at protecting society as well as the individual concerned.

  5. Cryptic female choice via sperm dumping favours male copulatory courtship in a spider.

    Science.gov (United States)

    Peretti, A V; Eberhard, W G

    2010-02-01

    Males of many animals perform 'copulatory courtship' during copulation, but the possible reproductive significance of this behaviour has seldom been investigated. In some animals, including the spider Physocyclus globosus (Pholcidae), the female discards sperm during or immediately following some copulations. In this study, we determined which of several variables associated with copulation correlated with paternity success in P. globosus when two males mate with a single female. Then, by determining which of these variables also correlated with sperm dumping, we inferred which variables may affect paternity via the mechanism of sperm dumping. Male abdomen vibration (a copulatory courtship behaviour) and male genitalic squeezing both correlated with both paternity and sperm dumping; so, these traits may be favoured by biased sperm dumping. Biased sperm dumping may also be the mechanism by which possible cryptic female choice favours another male trait that was the subject of a previous study, responsiveness to female stridulation.

  6. Employee participation in the private sector in Malaysia: The Applicability of Favourable Conjunctures Model

    Directory of Open Access Journals (Sweden)

    Balakrishnan Parasuraman

    2009-12-01

    Full Text Available EP is one crucial aspect of the employment relationship in both private and public organisations in many countries. In 2001, Poole, Lansbury and Wiles developed a model for comparative EP, which they named the Favourable Conjunctures Model. So far, this model has only been applied in developed countries such as the United States of America, United Kingdom, Australia and Europe. There it was applied in order to examine worker participation from the national perspective. No extensive study has been conducted using this model to explain worker participation practices at the company level. In parallel with this aspect, this model also has never been used to explain the nature of EP in the Asian developing countries. This current research will use the Favourable Conjunctures Model to examine the nature of EP in private enterprises based on empirical study carried out in Malaysia. The argument of this paper is that the Favourable Conjunctures Model of Industrial Democracy (Poole et al. 2001 is inadequate to elucidate the characteristics of EP in Malaysia. Based on empirical findings from three private companies in Malaysia, the paper argues that there are many contextual factors that influence the nature of EP in Malaysian private companies that are not taken into account by the model. They are:multi-ethnic (cultural influences, the repressive role of state in the Malaysian industrial relations, the New Economic Policy and industrialisation plan, Islamic working ethics, the influence of a British colonial history, lack of training among non-managerial employees in EP, the impact of foreign direct investment on industrial relations, to identify a few. Based on this study, it is proposed that the present Favourable Conjunctures Model of Industrial Democracy (Poole et al. 2001 be modified based on the contextual factors discussed above. The paper concludes that the western model of EP could not be directly applied in Malaysia without some adjustment of

  7. Determinants of favourable opinions about euthanasia in a sample of French physicians.

    Science.gov (United States)

    Dany, Lionel; Baumstarck, Karine; Dudoit, Eric; Duffaud, Florence; Auquier, Pascal; Salas, Sébastien

    2015-11-05

    The question whether euthanasia should be legalised has led to substantial public debate in France. The objective of this study in a sample of French physicians was to establish the potential determinants of a favourable opinion about euthanasia in general and when faced with a specific situation as embodied in the Humbert affair. The study was a cross-sectional survey investigating two different samples of medical doctors: (1) those specialised in palliative care and affiliated to the French Society for Patient Accompaniment and Palliative Care; (2) medical interns (medical doctors in training course) in a French medical university (Marseille). A questionnaire was sent (email) to each voluntary participant including sociodemographics, professional status, mention of believing in God, and opinion about euthanasia (the question was designed to assess the general opinion about euthanasia and the opinion about a specific case, the Vincent Humbert' case (a man who was rendered quadriplegic, blind, and mute after an accident and has requested euthanasia). A total of 413 physicians participated in the research (participation rate: 48.5%). Less than half of the population were favourable to euthanasia in general and almost two-thirds of the population were favourable to Vincent Humbert's request for euthanasia. Based on the multivariate analysis, individuals believing in God and being a medical intern were significant independent factors linked to having a favourable opinion about euthanasia in general and about the Vincent Humbert's request. There is still no study in France on the development of opinion about euthanasia and its impact. The issue goes beyond the strictly professional sphere and involves broader socio-political stakes. These stakes do not necessarily take into account medical practices and experiences or the desires of end-of-life patients. The professional upheaval that the future French legal framework will doubtlessly trigger will require further

  8. Will Hydrogen be Competitive in Europe without Tax-Favours?

    DEFF Research Database (Denmark)

    Hansen, Anders Chr.

    2010-01-01

    Hydrogen is one of the alternative transport fuels expected to replace conventional oil based fuels. The paper finds that it is possible for non-fossil-based hydrogen to become the lowest cost fuel without favourable tax treatment. The order of per kilometre cost depends on performance in hydrogen...... production, the international oil price, and fuel taxes. At low oil prices, the highest per kilometre costs were found for non-fossil power-based hydrogen, the second highest for natural gas-based hydrogen, and the lowest for conventional fuels. At high oil prices, this ranking is reversed and non......-fossil power-based hydrogen becomes the most cost competitive fuel. General fuel taxes lower the threshold at which the international oil price reverses this competitiveness order. The highest fuel tax rates applied in Europe lowers this threshold oil price considerably, whereas the lowest fuel taxes may...

  9. Physiological adaptations to weight loss and factors favouring weight regain.

    Science.gov (United States)

    Greenway, F L

    2015-08-01

    Obesity is a major global health problem and predisposes individuals to several comorbidities that can affect life expectancy. Interventions based on lifestyle modification (for example, improved diet and exercise) are integral components in the management of obesity. However, although weight loss can be achieved through dietary restriction and/or increased physical activity, over the long term many individuals regain weight. The aim of this article is to review the research into the processes and mechanisms that underpin weight regain after weight loss and comment on future strategies to address them. Maintenance of body weight is regulated by the interaction of a number of processes, encompassing homoeostatic, environmental and behavioural factors. In homoeostatic regulation, the hypothalamus has a central role in integrating signals regarding food intake, energy balance and body weight, while an 'obesogenic' environment and behavioural patterns exert effects on the amount and type of food intake and physical activity. The roles of other environmental factors are also now being considered, including sleep debt and iatrogenic effects of medications, many of which warrant further investigation. Unfortunately, physiological adaptations to weight loss favour weight regain. These changes include perturbations in the levels of circulating appetite-related hormones and energy homoeostasis, in addition to alterations in nutrient metabolism and subjective appetite. To maintain weight loss, individuals must adhere to behaviours that counteract physiological adaptations and other factors favouring weight regain. It is difficult to overcome physiology with behaviour. Weight loss medications and surgery change the physiology of body weight regulation and are the best chance for long-term success. An increased understanding of the physiology of weight loss and regain will underpin the development of future strategies to support overweight and obese individuals in their efforts

  10. Partner switching can favour cooperation in a biological market.

    Science.gov (United States)

    Schwagmeyer, P L

    2014-09-01

    Intraspecific cooperation and interspecific mutualisms can be promoted by mechanisms that reduce the frequency with which cooperative organisms are exploited by unhelpful partners. One such mechanism consists of changing partners after interacting with an uncooperative individual. I used McNamara et al.'s (Nature, 451, 2008, 189) partner switching model as a framework to examine whether this mechanism can select for increased cooperative investment by house sparrows (Passer domesticus) collaborating to rear offspring; previous research on this species has shown that substantial cooperative investments by both pair members are required to achieve high pay-offs from collaborating. I found that the poorer the outcome of a breeding attempt relative to the number of eggs the female invested, the greater the likelihood of partner switching. The incidence of partner switching changed seasonally, with peak switching coinciding with an increase in the number of alternative partners available to females. After females switched partners, their breeding outcomes rose to match those of females that remained with the same partner; this was not the case for males that switched partners. Consistent with the model's prediction, males in stable partnerships achieved over 25% higher than average reproductive success, which was attributable to both persistently good breeding outcomes and their older partners' high fecundity. These results provide empirical support for the hypothesis that partner switching favours increased cooperative investment levels, and they demonstrate that variation in the relative value of by-product benefits can enhance that process.

  11. Evolution of trust and trustworthiness: social awareness favours personality differences.

    Science.gov (United States)

    McNamara, John M; Stephens, Philip A; Dall, Sasha R X; Houston, Alasdair I

    2009-02-22

    Interest in the evolution and maintenance of personality is burgeoning. Individuals of diverse animal species differ in their aggressiveness, fearfulness, sociability and activity. Strong trade-offs, mutation-selection balance, spatio-temporal fluctuations in selection, frequency dependence and good-genes mate choice are invoked to explain heritable personality variation, yet for continuous behavioural traits, it remains unclear which selective force is likely to maintain distinct polymorphisms. Using a model of trust and cooperation, we show how allowing individuals to monitor each other's cooperative tendencies, at a cost, can select for heritable polymorphisms in trustworthiness. This variation, in turn, favours costly 'social awareness' in some individuals. Feedback of this sort can explain the individual differences in trust and trustworthiness so often documented by economists in experimental public goods games across a range of cultures. Our work adds to growing evidence that evolutionary game theorists can no longer afford to ignore the importance of real world inter-individual variation in their models.

  12. The Favourable Health Behaviours in Women from a Selected Urban Region in Kayseri

    Directory of Open Access Journals (Sweden)

    Hacer Sonmezer,Fevziye Cetinkaya,Melis Nacar

    2012-10-01

    Full Text Available Objective: In this study it was aimed to establish the favourable health behaviours in the life style of women, who also are in charge, and carry the responsibility of the whole family’s health. Material and Method: A questionnaire, inquiring about some favourable health behaviours, was applied to 421 women aged 18-64, living in an urban region in Kayseri. Results: The mean age of the study group was 36.2±11.1, 57.1% were housewives, 74.3% were married, and the educational level of 62.7% was high school and above. The rate of obtaining information from health personnel was 9.7%, and most women(31.1% stated media as their source of information. 67.0% did not smoke. 44.4% of the study group were with in normal weight, and 66.3% stated that they had breakfast. 32.3% of the women stated that they restricted salt in food, and 18.8% restricted sugar, 20.4% tried not to consume tea following a meal and 32.1% stated that they were always careful about not using saturated fat while cooking. 16.2% of the women stated that they self-examined their breats on a regular basis, 54.0% that they did so sometimes, 41.6% had had a clinical breast examination. The rate of mammograhpic evaluation above the age of 40 was 78.0%. Conclusion: The awareness about and the applications for favourable health behaviours as a life style were found to be insufficient in women. It is the duty and responsibility of health personnel to establish healthy life style behaviours in women. [TAF Prev Med Bull 2012; 11(5.000: 521-528

  13. Evaluation of the Favourable Ecological Impact of the Railway on the Environment

    Directory of Open Access Journals (Sweden)

    Jasna Golubić

    2012-10-01

    Full Text Available The railway has advantages over other branches of longdistancetransportation from the ecological, economic, safety,and technological point of view.The paper gives an evaluation of the favourable influenceof railway traffic on the environment reflected in the rationalenergy consumption, significantly reduced need of physicalspace, and reduced air pollution.Having these data in mind, the railway is considered tohave a negligible influence on environmental pollution. However,studying even such small amounts plays a significant rolein the traffic safety and in the lives of people and nature itself

  14. The process of internationalization of the nursing and midwifery curriculum: A qualitative study.

    Science.gov (United States)

    Abdul-Mumin, Khadizah H

    2016-11-01

    There is an abundance of literature on internationalization of curricula. However, research on how a curriculum is internationalized to accommodate non-mobile students studying in their home countries is limited. To describe the process undertaken by curriculum developers in internationalizing the Brunei nursing and midwifery curriculum through curriculum design. A descriptive qualitative research design. A nursing and midwifery higher education institution in Brunei. Seventeen nurse/midwife academics. Semi-structured interviews were conducted with 17 curriculum developers. Data were analyzed using thematic analysis. Four themes emerged: expectations of an internationalized curriculum; formation of a committee; benchmarking and setting standards; and designing the curriculum for internationalization. This study has implications for the development of an internationally-oriented curriculum that takes into account the cultural context of a specific country. The findings highlight the need to involve students in curriculum design, a practice that is not common in Brunei. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Emergence and nosocomial spread of carbapenem-resistant OXA-232-producing Klebsiella pneumoniae in Brunei Darussalam

    NARCIS (Netherlands)

    Abdul Momin, Muhd Haziq Fikry; Liakopoulos, Apostolos; Phee, Lynette M.; Wareham, David W.

    2017-01-01

    Objectives Carbapenem-resistant Enterobacteriaceae (CRE) are identified as a major global health concern. The success of CRE is facilitated by the emergence, acquisition and spread of successful clones carrying plasmid-encoded resistance genes. In this study, an outbreak of carbapenem-resistant

  16. Human resource management in domestic vs. multinational enterprises: an investigation in the country of Brunei

    OpenAIRE

    Mohamed, Abdul Fattaah

    2012-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. Very little past work has focused on the comparative analysis of human resource management (HRM) practices between domestic (DEs) and multinational enterprises (MNEs). The majority of the work in this area has instead concentrated on comparing the HRM practices employed by the subsidiaries of MNEs, and has mostly been conducted in the context of developed countries. This research studies t...

  17. Chemical characterisation of the haze in Brunei Darussalam during the 1998 episode

    Science.gov (United States)

    Muraleedharan, T. R.; Radojevic, Miroslav; Waugh, Allan; Caruana, Anthony

    Coinciding with the El-Nino Southern Oscillation (ENSO) of 1997-1998, SE Asia experienced a severe air pollution episode locally referred to as haze. The monitoring and response efforts in the region mainly centred around criteria pollutants, though it was obvious that the pollution episode is fundamentally different from classical urban air pollution. This paper reports the results of the first-ever study of the detailed chemical composition of the haze in SE Asia. Although numerous studies of forest fire plumes have been conducted in other parts of the world, ours is the first study to be carried out with the specific aim of identifying and quantifying chemical components which are likely to have long-term human health implications. Volatile organic compounds (VOCs) including BTEX (benzene, toluene, ethylbenzene, and xylene), aldehydes, cresol, phenol, acetic acid, polynuclear aromatic hydrocarbons (PAHs), suspended particles teratogens (e.g. benzene, toluene, xylene, PAHs), and they have the potential to cause serious long-term effects.

  18. Statistical Estimation of Dose-response Functions of Respiratory Diseases and Societal Costs of Haze-related Air Pollution in Brunei Darussalam

    Science.gov (United States)

    Anaman, K. A.; Ibrahim, N.

    - The effects on human health resulting from the January to April 1998 haze-related air pollution episode in Brunei Darussalam were analysed for five groups of diseases of the respiratory system. The analysis concentrated on the statistical estimation of dose-response functions which related the number of cases of respiratory diseases to the level of quality of ambient environment as measured by the pollutants standards index (PSI) and other environmental variables. The total number of cases of the five groups of diseases was shown to be significantly related to PSI and temperature. Societal costs were also estimated. The results showed that societal costs were significantly related to PSI, temperature and relative humidity. Societal costs increased with higher PSI and relative humidity but decreased with increasing temperature.

  19. A Competition Law Assessment of Platform Most-Favoured-Customer Clauses

    OpenAIRE

    Akman, P

    2016-01-01

    Most-favoured-customer (MFC) clauses adopted by online platforms in their relevant contractual relationships guarantee to an online platform that a supplier will treat the platform as favourably as the supplier’s most-favoured-customer concerning price, availability and similar terms of a given transaction. These clauses are a fundamental aspect of the business models of some of the world’s leading companies such as Apple, Amazon, Expedia, etc. The competition law implications of these clause...

  20. Experimental evidence for mutual inter- and intrasexual selection favouring a crested auklet ornament.

    Science.gov (United States)

    Jones; Hunter

    1999-03-01

    During the breeding season, female and male crested auklets Aethia cristatella (Alcidae), display similar conspicuous crest ornaments composed of elongated forward-curving feathers on their foreheads. Based on quantifications of brief agonistic interactions at a large breeding colony, we found that crest length was strongly correlated with dominance within both sexes. Across the full range of crest length, individuals with longer crests were dominant over shorter-crested individuals in agonistic interactions involving same-sex adults. Within subadults (2-year-olds of unknown sex), there was a similar trend towards longer-crested individuals being dominant. In agonistic interactions involving individuals of different sex and age, adult males were dominant over adult females and adults were dominant over subadults, regardless of crest length. In an experiment in which we manipulated crest length using life-size realistic models, male auklets that responded were less aggressive to male models with longer crests than to models with normal or shorter crests, confirming that crest length by itself signals dominance status. In a related experiment in which we controlled intrasexual competition, both males and females responded to opposite-sex models with more frequent sexual displays when the models had long crests compared with those having short crests, suggesting that crested auklets also have mating preferences that favour long crest ornaments. Taken together, these results support the idea that the crest ornament is favoured by both intra- and intersexual selection. Copyright 1999 The Association for the Study of Animal Behaviour.

  1. Why increasing longevity may favour a PAYG pension system over a funded system.

    Science.gov (United States)

    Ediev, Dalkhat M

    2014-03-01

    When pension systems are contrasted it is common to use simplified demographic models, such as overlapping generation models with time-invariant mortality. Breaking with this tradition, we show that for a population with increasing longevity, the pay-as-you-go (PAYG) system may be more advantageous than a funded system (FS). Increasing longevity favours the PAYG system because for the workers living longer at retirement than current retirees, it is less costly to fund others' current pensions than their own. At present, the effect amounts to around 15 per cent in terms of the dependency ratio, or six more years at work in the FS, or 1 per cent per annum in terms of the real interest rate. In most developed countries the effect substantially exceeds that of the usually studied biological interest rate.

  2. Phosphorylation controls the functioning of Staphylococcus aureus isocitrate dehydrogenase--favours biofilm formation.

    Science.gov (United States)

    Prasad, U Venkateswara; Vasu, D; Yeswanth, S; Swarupa, V; Sunitha, M M; Choudhary, A; Sarma, P V G K

    2015-01-01

    Isocitrate dehydrogenase (IDH) gene from Staphylococcus aureus ATCC12600 was cloned, sequenced and characterized (HM067707). PknB site was observed in the active site of IDH; thus, it was predicted as IDH may be regulated by phosphorylation. Therefore, in this study, PknB, alkaline phosphatase III (SAOV 2675) and IDH genes (JN695616, JN645811 and HM067707) of S. aureus ATCC12600 were over expressed from clones PV 1, UVPALP-3 and UVIDH 1. On passing the cytosloic fractions through nickel metal chelate column, pure enzymes were obtained. Phosphorylation of pure IDH by PknB resulted in the complete loss of activity and was restored upon dephosphorylation with SAOV 2675 which indicated that phosphorylation and dephosphorylation regulate IDH activity in S. aureus. Further, when S. aureus ATCC12600 was grown in BHI broth, decreased IDH activity and increased biofilm units were observed; therefore, this regulation of IDH alters redox status in this pathogen favouring biofilm formation.

  3. Sleep to the beat : A nap favours consolidation of timing

    NARCIS (Netherlands)

    Verweij, Ilse M; Onuki, Yoshiyuki; Van Someren, Eus J W; Van der Werf, Ysbrand D

    Growing evidence suggests that sleep is important for procedural learning, but few studies have investigated the effect of sleep on the temporal aspects of motor skill learning. We assessed the effect of a 90-min day-time nap on learning a motor timing task, using 2 adaptations of a serial

  4. Sleep to the beat : A nap favours consolidation of timing

    NARCIS (Netherlands)

    Verweij, Ilse M; Onuki, Yoshiyuki; Van Someren, Eus J W; Van der Werf, Ysbrand D

    2016-01-01

    Growing evidence suggests that sleep is important for procedural learning, but few studies have investigated the effect of sleep on the temporal aspects of motor skill learning. We assessed the effect of a 90-min day-time nap on learning a motor timing task, using 2 adaptations of a serial intercept

  5. Does displayed enthusiasm favour recall, intrinsic motivation and time estimation?

    Science.gov (United States)

    Moè, Angelica

    2016-11-01

    Displayed enthusiasm has been shown to relate to intrinsic motivation, vitality, and positive affect, but its effects on recall performance and time estimation have not yet been explored. This research aimed at studying the effects of a delivery style characterised by High Enthusiasm (HE) on recall, time estimation, and intrinsic motivation. In line with previous studies, effects on intrinsic motivation were expected. In addition, higher recall and lower time estimations were hypothesised. In two experiments, participants assigned to a HE condition or to a normal reading control condition listened to a narrative and to a descriptive passage. Then, they were asked to rate perceived time, enthusiasm, pleasure, interest, enjoyment and curiosity, before writing a free recall. Experiment 1 showed that in the HE condition, participants recalled more, were more intrinsically motivated, and expressed lower time estimations compared to the control condition. Experiment 2 confirmed the positive effects of HE reading compared to normal reading, using different passages and a larger sample.

  6. The favourable large misorientation angle grain boundaries in graphene.

    Science.gov (United States)

    Zhang, Xiuyun; Xu, Ziwei; Yuan, Qinghong; Xin, John; Ding, Feng

    2015-12-21

    A grain boundary (GB) in graphene is a linear defect between two specifically oriented graphene edges, whose title angles are denoted as θ1 and θ2, respectively. Here we present a systematic theoretical study on the structure and stability of GBs in graphene as a function of the misorientation angle, Φ = (θ1-θ2) and the GB orientation in multi-crystalline graphene, which is denoted by Θ = (θ1 + θ2). It is surprising that although the number of disorders of the GB, i.e., the pentagon-heptagon pairs (5|7s), reaches the maximum at Φ∼ 30°, the GB formation energy versus the Φ curve reaches a local minimum. The subsequent M-shape of the Efvs. the Φ curve is due to the strong cancellation of the local strains around 5|7 pairs by the "head-to-tail" formation. This study successfully explains many previously observed experimental puzzles, such as the multimodal distribution of GBs and the abundance of GB misorientation angles of ∼30°. Besides, this study also showed that the formation energy of GBs is less sensitive to Θ, although the twin boundaries are slightly more stable than others.

  7. Plastic traits of an exotic grass contribute to its abundance but are not always favourable.

    Directory of Open Access Journals (Sweden)

    Jennifer Firn

    Full Text Available In herbaceous ecosystems worldwide, biodiversity has been negatively impacted by changed grazing regimes and nutrient enrichment. Altered disturbance regimes are thought to favour invasive species that have a high phenotypic plasticity, although most studies measure plasticity under controlled conditions in the greenhouse and then assume plasticity is an advantage in the field. Here, we compare trait plasticity between three co-occurring, C(4 perennial grass species, an invader Eragrostis curvula, and natives Eragrostis sororia and Aristida personata to grazing and fertilizer in a three-year field trial. We measured abundances and several leaf traits known to correlate with strategies used by plants to fix carbon and acquire resources, i.e. specific leaf area (SLA, leaf dry matter content (LDMC, leaf nutrient concentrations (N, C:N, P, assimilation rates (Amax and photosynthetic nitrogen use efficiency (PNUE. In the control treatment (grazed only, trait values for SLA, leaf C:N ratios, Amax and PNUE differed significantly between the three grass species. When trait values were compared across treatments, E. curvula showed higher trait plasticity than the native grasses, and this correlated with an increase in abundance across all but the grazed/fertilized treatment. The native grasses showed little trait plasticity in response to the treatments. Aristida personata decreased significantly in the treatments where E. curvula increased, and E. sororia abundance increased possibly due to increased rainfall and not in response to treatments or invader abundance. Overall, we found that plasticity did not favour an increase in abundance of E. curvula under the grazed/fertilized treatment likely because leaf nutrient contents increased and subsequently its' palatability to consumers. E. curvula also displayed a higher resource use efficiency than the native grasses. These findings suggest resource conditions and disturbance regimes can be manipulated to

  8. Cervicofacial necrotizing fasciitis: can we expect a favourable outcome?

    Science.gov (United States)

    Panda, Naresh K; Simhadri, Sridhar; Sridhara, Suryanarayana Rao

    2004-10-01

    Necrotizing fasciitis of the head and neck is an uncommon, progressive, destructive soft tissue infection of mixed aerobic and anaerobic organisms, having high mortality if left untreated (22 to 100 per cent). This study makes an attempt to analyse various factors and management methods determining the overall prognosis. A retrospective analysis of all cases of necrotizing fasciitis involving the head and neck, with exclusion of those involving the eyelid and the scalp, was undertaken. Various parameters such as demography, aetiology, complications, management and outcome were studied. Males outnumbered the females with the latter having a greater risk of involvement after 60 years. Odontogenic infection was the primary source of infection. Anaerobes were cultured in seven out of 17 cases, with six others showing mixed Gram positive and Gram negative organisms. Anaemia was the most commonly associated illness, with diabetes affecting four out of 17 cases. Aggressive surgical debridement with triple antibiotic therapy was used in the management of necrotizing fasciitis with an overall mortality of 11.8 per cent. Patients having late referral, anaemia and one or other complication had increased duration of total hospital stay. Better results can be obtained with proper control of infection by early diagnosis, aggressive surgical debridement and triple antibiotic therapy, along with timely control of complications and associated illnesses.

  9. Natural selection can favour ‘irrational’ behaviour

    Science.gov (United States)

    McNamara, J. M.; Trimmer, P. C.; Houston, A. I.

    2014-01-01

    Understanding decisions is the fundamental aim of the behavioural sciences. The theory of rational choice is based on axiomatic principles such as transitivity and independence of irrelevant alternatives (IIA). Empirical studies have demonstrated that the behaviour of humans and other animals often seems irrational; there can be a lack of transitivity in choice and seemingly irrelevant alternatives can alter decisions. These violations of transitivity and IIA undermine rational choice theory. However, we show that an individual that is maximizing its rate of food gain can exhibit failure of transitivity and IIA. We show that such violations can be caused because a current option may disappear in the near future or a better option may reappear soon. Current food options can be indicative of food availability in the near future, and this key feature can result in apparently irrational behaviour. PMID:24429682

  10. HPV status and favourable outcome in vulvar squamous cancer.

    Science.gov (United States)

    Wakeham, Katie; Kavanagh, Kim; Cuschieri, Kate; Millan, David; Pollock, Kevin G; Bell, Sarah; Burton, Kevin; Reed, Nicholas S; Graham, Sheila V

    2017-03-01

    It is universally accepted that high-risk human papillomavirus (HR-HPV) is the cause of cervical dysplasia and cancer. More recently, it has been shown that HPV is also a marker of clinical outcome in oropharyngeal cancer. However, contemporary information is lacking on both the prevalence of HPV infection in vulvar cancer (VSCC), its precursor lesion, vulvar intraepithelial neoplasia (VIN) and the influence of HPV-status on the prognosis of this malignancy. We have conducted a detailed population-based study to examine rates of progression of VIN to VSCC, type-specific HPV prevalence in vulvar disease and the influence of HPV status on clinical outcome in VSCC. We observed that the age at which women are diagnosed with VSCC is falling and there is a significant time gap between first diagnosis of VIN and progression to invasive disease. HR-HPV infection was detected in 87% (97/112) cases of VIN and 52% cases (32/62) of VSCC. The presence of HR-HPV in squamous intraepithelial lesion was associated with lower rates of progression to invasive cancer (hazard ratio, 0.22, p = 0.001). In the adjusted analysis, HR-HPV was associated with improved progression-free survival of VSCC compared to those with HPV negative tumours (hazard ratio, 0.32, p = 0.02).

  11. Protist predation can favour cooperation within bacterial species

    Science.gov (United States)

    Friman, Ville-Petri; Diggle, Stephen P.; Buckling, Angus

    2013-01-01

    Here, we studied how protist predation affects cooperation in the opportunistic pathogen bacterium Pseudomonas aeruginosa, which uses quorum sensing (QS) cell-to-cell signalling to regulate the production of public goods. By competing wild-type bacteria with QS mutants (cheats), we show that a functioning QS system confers an elevated resistance to predation. Surprisingly, cheats were unable to exploit this resistance in the presence of cooperators, which suggests that resistance does not appear to result from activation of QS-regulated public goods. Instead, elevated resistance of wild-type bacteria was related to the ability to form more predation-resistant biofilms. This could be explained by the expression of QS-regulated resistance traits in densely populated biofilms and floating cell aggregations, or alternatively, by a pleiotropic cost of cheating where less resistant cheats are selectively removed from biofilms. These results show that trophic interactions among species can maintain cooperation within species, and have further implications for P. aeruginosa virulence in environmental reservoirs by potentially enriching the cooperative and highly infective strains with functional QS system. PMID:23945212

  12. Initial community evenness favours functionality under selective stress.

    Science.gov (United States)

    Wittebolle, Lieven; Marzorati, Massimo; Clement, Lieven; Balloi, Annalisa; Daffonchio, Daniele; Heylen, Kim; De Vos, Paul; Verstraete, Willy; Boon, Nico

    2009-04-01

    Owing to the present global biodiversity crisis, the biodiversity-stability relationship and the effect of biodiversity on ecosystem functioning have become major topics in ecology. Biodiversity is a complex term that includes taxonomic, functional, spatial and temporal aspects of organismic diversity, with species richness (the number of species) and evenness (the relative abundance of species) considered among the most important measures. With few exceptions (see, for example, ref. 6), the majority of studies of biodiversity-functioning and biodiversity-stability theory have predominantly examined richness. Here we show, using microbial microcosms, that initial community evenness is a key factor in preserving the functional stability of an ecosystem. Using experimental manipulations of both richness and initial evenness in microcosms with denitrifying bacterial communities, we found that the stability of the net ecosystem denitrification in the face of salinity stress was strongly influenced by the initial evenness of the community. Therefore, when communities are highly uneven, or there is extreme dominance by one or a few species, their functioning is less resistant to environmental stress. Further unravelling how evenness influences ecosystem processes in natural and humanized environments constitutes a major future conceptual challenge.

  13. Meta-analysis of phenotypic selection on flowering phenology suggests that early flowering plants are favoured.

    Science.gov (United States)

    Munguía-Rosas, Miguel A; Ollerton, Jeff; Parra-Tabla, Victor; De-Nova, J Arturo

    2011-05-01

    Flowering times of plants are important life-history components and it has previously been hypothesized that flowering phenologies may be currently subject to natural selection or be selectively neutral. In this study we reviewed the evidence for phenotypic selection acting on flowering phenology using ordinary and phylogenetic meta-analysis. Phenotypic selection exists when a phenotypic trait co-varies with fitness; therefore, we looked for studies reporting an association between two components of flowering phenology (flowering time or flowering synchrony) with fitness. Data sets comprising 87 and 18 plant species were then used to assess the incidence and strength of phenotypic selection on flowering time and flowering synchrony, respectively. The influence of dependence on pollinators, the duration of the reproductive event, latitude and plant longevity as moderators of selection were also explored. Our results suggest that selection favours early flowering plants, but the strength of selection is influenced by latitude, with selection being stronger in temperate environments. However, there is no consistent pattern of selection on flowering synchrony. Our study demonstrates that phenotypic selection on flowering time is consistent and relatively strong, in contrast to previous hypotheses of selective neutrality, and has implications for the evolution of temperate floras under global climate change. © 2011 Blackwell Publishing Ltd/CNRS.

  14. Airborne Quercus pollen in SW Spain: Identifying favourable conditions for atmospheric transport and potential source areas.

    Science.gov (United States)

    Maya-Manzano, José María; Fernández-Rodríguez, Santiago; Smith, Matt; Tormo-Molina, Rafael; Reynolds, Andrew M; Silva-Palacios, Inmaculada; Gonzalo-Garijo, Ángela; Sadyś, Magdalena

    2016-11-15

    The pollen grains of Quercus spp. (oak trees) are allergenic. This study investigates airborne Quercus pollen in SW Spain with the aim identifying favourable conditions for atmospheric transport and potential sources areas. Two types of Quercus distribution maps were produced. Airborne Quercus pollen concentrations were measured at three sites located in the Extremadura region (SW Spain) for 3 consecutive years. The seasonal occurrence of Quercus pollen in the air was investigated, as well as days with pollen concentrations ≥80Pm(-3). The distance that Quercus pollen can be transported in appreciable numbers was calculated using clusters of back trajectories representing the air mass movement above the source areas (oak woodlands), and by using a state-of-the-art dispersion model. The two main potential sources of Quercus airborne pollen captured in SW Spain are Q. ilex subsp. ballota and Q. suber. The minimum distances between aerobiological stations and Quercus woodlands have been estimated as: 40km (Plasencia), 66km (Don Benito), 62km (Zafra) from the context of this study. Daily mean Quercus pollen concentration can exceed 1,700Pm(-3), levels reached not less than 24 days in a single year. High Quercus pollen concentration were mostly associated with moderate wind speed events (6-10ms(-1)), whereas that a high wind speed (16-20ms(-1)) seems to be associated with low concentrations.

  15. Geological Conditions Favourable for High-Wax Oil Enrichment in Damintun Depression,Bohai Bay Basin

    Institute of Scientific and Technical Information of China (English)

    Zhu Fangbing

    2009-01-01

    The Damintun (大民屯) depression,a small (about 800 km2 in area) subunit in the Bohai (渤海) Bay basin,hosts nearly 2×108t of high-wax oils with wax contents up to 60%. The high-wax oils have high consolidation temperatures and viscosities.The high-wax oils were generated from the fourth member of the Shahejie Formation (Es4),which is also important source rocks for oils in other subunits of the Bohai Bay basin.Yet high-wax oils have not been found in significant volumes elsewhere in the Bohai Bay basin.Geological conditions favourable for high-wax oil enrichment were studied.This study shows that the unusual concentrations of high-wax oils in the depression seem to result from at least three different factors: (1) the presence of organic-matter rich source rocks which were prone to generate wax-rich hydrocarbons; (2) the formation of early overpressures which increased the expulsion efficiency of waxy hydrocarbons; and (3) reductions in subsidence rate and basal heat flows,which minimized the thermal cracking of high molecular-weight (waxy) hydrocarbons,and therefore prevented the high-wax oils from being transformed into less waxy equivalents.

  16. Donor's age and replicative senescence favour the in-vitro mineralization potential of human fibroblasts.

    Science.gov (United States)

    Boraldi, Federica; Bartolomeo, Angelica; Di Bari, Caterina; Cocconi, Andrea; Quaglino, Daniela

    2015-12-01

    Aberrant mineralization of soft connective tissues (ectopic calcification) may occur as a frequent age-related complication. Still, it remains unclear the role of mesenchymal cell donor's age and of replicative senescence on ectopic calcification. Therefore, the ability of cells to deposit in-vitro hydroxyapatite crystals and the expression of progressive ankylosis protein homolog (ANKH), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), tissue non specific alkaline phosphatase (TNAP) and osteopontin (OPN) have been evaluated in human dermal fibroblasts derived from neonatal (nHDF) and adult (aHDF) donors (ex-vivo ageing model) or at low and high cumulative population doublings (CPD) up to replicative senescence (in-vitro ageing model). This study demonstrates that: 1) replicative senescence favours hydroxyapatite formation in cultured fibroblasts; 2) donor's age acts as a major modulator of the mineralizing potential of HDF, since nHDF are less prone than aHDF to induce calcification; 3) donor's age and replicative senescence play in concert synergistically increasing the calcification process; 4) the ANKH+ENPP1/TNAP ratio, being crucial for pyrophosphate/inorganic phosphate balance, is greatly influenced by donor's age, as well as by replicative senescence, and regulates mineral deposition; 5) OPN is only modulated by replicative senescence.

  17. Is earthquake activity along the French Atlantic margin favoured by local rheological contrasts?

    Science.gov (United States)

    Mazabraud, Yves; Béthoux, Nicole; Delouis, Bertrand

    2013-09-01

    The seismological study of recent seismic crises near Oleron Island confirms the coexistence of an extensional deformation and a transtensive regime in the Atlantic margin of France, which is different from the general western European stress field corresponding to a strike-slip regime. We argue that the switch of the principal stress axes σ1/σ2 in a NW-SE vertical plane is linked with the existence of crustal heterogeneities. Events of magnitude larger than 5 sometimes occur along the Atlantic margin of France, such as the 7 September 1972 (ML = 5.2) earthquake near Oleron island and the 30 September 2002 (ML = 5.7) Hennebont event in Brittany. To test the mechanism of local strain localization, we model the deformation of the hypocentral area of the Hennebont earthquake using a 3D thermo-mechanical finite element code. We conclude that the occurrence of moderate earthquakes located in limited parts of the Hercynian shear zones (as the often reactivated swarms near Oleron) could be due to local reactivation of pre-existing faults. These sporadic seismic ruptures are favoured by stress concentration due to rheological heterogeneities.

  18. The Progenitors of the Milky Way Stellar Halo: Big Bricks Favoured over Little Bricks

    CERN Document Server

    Deason, A J; Weisz, D R

    2015-01-01

    We present a census of blue horizontal branch (BHB) and blue straggler (BS) stars belonging to dwarf galaxies and globular clusters, and compare these counts to that of the Milky Way stellar halo. We find, in agreement with earlier studies, that the ratio of BS-to-BHB stars in these satellite populations is dependent on stellar mass. Dwarf galaxies show an increasing BS-to-BHB ratio with luminosity. In contrast, globular clusters display the reverse trend, with N_BS/N_BHB (< 1) decreasing with luminosity. The faintest (L < 10^5 L_Sun) dwarfs have similar numbers of BS and BHB stars (N_BS/N_BHB ~ 1), whereas more massive dwarfs tend to be dominated by BS stars (N_BS/N_BHB ~ 2-40). We find that the BS-to-BHB ratio in the stellar halo is relatively high (N_BS/N_BHB ~ 5-6), and thus inconsistent with the low ratios found in both ultra-faint dwarfs and globular clusters. Our results favour more massive dwarfs as the dominant "building blocks" of the stellar halo, in good agreement with current predictions fr...

  19. Learning styles favoured by professional, amateur, and recreational athletes in different sports.

    Science.gov (United States)

    González-Haro, Carlos; Calleja-González, Julio; Escanero, Jesus F

    2010-06-01

    The aim of this study was to characterize the learning styles of different groups of athletes grouped according to level of performance and sport. Seventy-one male athletes completed a questionnaire on learning styles at the beginning of the 2008-2009 training season. Learning styles were assessed using the Honey-Alonso Learning Styles Questionnaire, and were also converted into learning styles described by Kolb. The Honey-Alonso learning styles were compared among the various groups using one-way analysis of variance, and the Kolb learning styles that were most favoured using a chi-square test. Pearson's correlation coefficient was used to verify the relationships between variables. No significant differences were observed in learning styles between different sports and physical activities. Years of experience did not correlate strongly with learning styles. With respect to level of performance, the pragmatic component was significantly lower in professional athletes than amateur and recreational athletes. These characteristics of learning styles preferred by the athletes should help coaches and physical trainers to reflect on their role as educators in the context of planning sports training.

  20. Living with strangers: direct benefits favour non-kin cooperation in a communally nesting bird.

    Science.gov (United States)

    Riehl, Christina

    2011-06-07

    The greater ani (Crotophaga major), a Neotropical cuckoo, exhibits an unusual breeding system in which several socially monogamous pairs lay eggs in a single nest and contribute care to the communal clutch. Cooperative nesting is costly-females compete for reproduction by ejecting each other's eggs-but the potential direct or indirect fitness benefits that might accrue to group members have not been identified. In this study, I used molecular genotyping to quantify patterns of genetic relatedness and individual reproductive success within social groups in a single colour-banded population. Microsatellite analysis of 122 individuals in 49 groups revealed that group members are not genetic relatives. Group size was strongly correlated with individual reproductive success: solitary pairs were extremely rare and never successful, and nests attended by two pairs were significantly more likely to be depredated than were nests attended by three pairs. Egg loss, a consequence of reproductive competition, was greater in large groups and disproportionately affected females that initiated laying. However, early-laying females compensated for egg losses by laying larger clutches, and female group members switched positions in the laying order across nesting attempts. The greater ani, therefore, appears to be one of the few species in which cooperative breeding among unrelated individuals is favoured by direct, shared benefits that outweigh the substantial costs of reproductive competition.

  1. Al-Islām wa al-Malāyū wa al-Siyādah fī al-Muḥīṭ: Sulṭanat Brunei wa al-Isti‘mār Eropa fī Borneo

    OpenAIRE

    Dadi Darmadi

    2015-01-01

    The politics and trade in Southeast Asia since the 7th century had seen the early rise of Brunei as an important port in Borneo. When the Malacca fell to the Portuguese in 1511, Islam spread to northern Borneo.  Brunei grew as a new, powerful Islamic sultanate; European traders stopped by its port as they bought spices in the Moluccas. Friendships and conflicts of interest between the two powers were exacerbated by the issue of Christianization and Islamization. In the 16th century the confli...

  2. The Significance of Social Relationships in Learning to Become a Vocational and Technical Education Teacher: A Case Study of Three Individuals

    Science.gov (United States)

    Goh, Adeline Yuen Sze

    2013-01-01

    This article about workplace learning examines the learning of individuals in becoming a Vocational and Technical Education (VTE) teacher in Brunei. Drawing on research findings from a group of student teachers, it presents case study accounts of three individuals to illustrate the importance of social relationships in learning to become a VTE…

  3. The Significance of Social Relationships in Learning to Become a Vocational and Technical Education Teacher: A Case Study of Three Individuals

    Science.gov (United States)

    Goh, Adeline Yuen Sze

    2013-01-01

    This article about workplace learning examines the learning of individuals in becoming a Vocational and Technical Education (VTE) teacher in Brunei. Drawing on research findings from a group of student teachers, it presents case study accounts of three individuals to illustrate the importance of social relationships in learning to become a VTE…

  4. Language Shift Caused by Language Policy at Brunei%文莱语言政策影响下的语言转化

    Institute of Scientific and Technical Information of China (English)

    袁洁

    2016-01-01

    Sultan,the head and Prime Minister of Negara Brunei Darussalam,advocates the ideology“Malay,Islam and Monarchy”with a series of policies to assimilate non Malay and non Muslim citizens in the country.As a result,non Malay languages are assimilated by the official language Malay in line with the ideology in terms of word formation and syntax.Both Malay and the second language English have been promoted by the Bilingual Language Education Policy since 1985.With the orientation of language policy,indigenous languages tend to be reduced or even wiped out.%文莱在苏丹王的统治之下大力推行“马来化、伊斯兰化和君主制”,通过一系列的政策同化非马来族和非伊斯兰教的国民。非马来语在全国统一的意识形态下构词和句法上受到官方语言马来语同化;第二语言英语在文莱现代化进程中扮演重要角色,语言教育政策进一步加强了它的社会地位。就文莱语言生态现状来看,少数民族语言正逐年减少而呈弱化、消亡趋势,语言多样性生存空间较小。

  5. Darwin's Arguments in Favour of Natural Selection and against Special Creationism

    Science.gov (United States)

    Nola, Robert

    2013-01-01

    In many places in "The Origin of Species", Darwin compares his own theory of Natural Selection favourably with Special Creationism which comes off as a bad second best. He does this using some version of the argument form known as "Inference to the Best Explanation". The first part of this paper is methodological. It considers Whewell's notion of…

  6. Does disturbance favour weak competitors? Mechanisms of changing plant abundance after flooding

    NARCIS (Netherlands)

    Lenssen, J.P.M.; Steeg, A. van der; Kroon, J.C.J.M. de

    2004-01-01

    Question: Does disturbance reduce competition intensity and thus favour weak competitors that are presumably less affected by disturbance than strong competitors? Methods: We used a single flooding event with increasing duration to simulate disturbance with increasing intensity. Six flood-plain gras

  7. Sequential use of human-derived medium supplements favours cardiovascular tissue engineering

    NARCIS (Netherlands)

    Vis, Paul W. Riem; Sluijter, Joost P. G.; Soekhradj-Soechit, R. Sarita; van Herwerden, Lex A.; Kluin, Jolanda; Bouten, Carlijn V. C.

    2012-01-01

    For clinical application of tissue engineering strategies, the use of animal-derived serum in culture medium is not recommended, because it can evoke immune responses in patients. We previously observed that human platelet-lysate (PL) is favourable for cell expansion, but generates weaker tissue as

  8. Sequential use of human-derived medium supplements favours cardiovascular tissue engineering

    NARCIS (Netherlands)

    Vis, Paul W. Riem; Sluijter, Joost P. G.; Soekhradj-Soechit, R. Sarita; van Herwerden, Lex A.; Kluin, Jolanda; Bouten, Carlijn V. C.

    2012-01-01

    For clinical application of tissue engineering strategies, the use of animal-derived serum in culture medium is not recommended, because it can evoke immune responses in patients. We previously observed that human platelet-lysate (PL) is favourable for cell expansion, but generates weaker tissue as

  9. Darwin's Arguments in Favour of Natural Selection and against Special Creationism

    Science.gov (United States)

    Nola, Robert

    2013-01-01

    In many places in "The Origin of Species", Darwin compares his own theory of Natural Selection favourably with Special Creationism which comes off as a bad second best. He does this using some version of the argument form known as "Inference to the Best Explanation". The first part of this paper is methodological. It considers Whewell's notion of…

  10. Trade policies and development of less-favoured areas: evidence from the literature

    NARCIS (Netherlands)

    Oskam, A.J.; Komen, M.H.C.; Wobst, P.; Yalew, A.

    2004-01-01

    The links between international markets and production and consumption decisions in less-favoured areas (LFAs) often appear rather loose. Hence, it may be questioned whether international trade and economic growth effects trickle down to LFAs. This paper explores the evidence in the literature in wh

  11. Does the energy expenditure status in obstructive sleep apnea favour a positive energy balance?

    Science.gov (United States)

    Major, Geneviève C; Sériès, Frédéric; Tremblay, Angelo

    2007-01-01

    The effect of the obstructive sleep apnea syndrome on energy expenditure is controversial. The objective of this study was to assess the relationship between 24-hr energy expenditure or sleeping metabolic rate and features of the obstructive sleep apnea. Twenty-four apneic men took part in this cross-sectional study and were classified in quartiles of nocturnal desaturation severity, i.e. of percentage total sleep time with SaO2 hydrodensitometry. During the stay in the respiratory chamber, urine was collected to assess catecholamine concentration and percentage recording time with SaO2 < 90% (%TRT SaO2 < 90%) was measured with nocturnal oximetry. Mean fat free mass and fat mass were greater in quartile 4 than in quartile 1 (P < 0.05). %TRT SaO2 < 90% was higher in quartile 4 than in other quartiles (P < 0.0001). 24-hr energy expenditure and sleeping metabolic rate were similar among quartiles. However, when expressed on a per kg body weight basis (kcal/kg), these variables were negatively correlated with the %TRT SaO2 < 90% in the whole group (r = -0.46 and -0.48, respectively, P < 0.05). %TRT SaO2 < 90% was found to be a predictor of sleeping metabolic rate which explained, together with fat mass and fat free mass, 86% of this variance (P < 0.05). In apneic men energy expenditure relative to body weight decreases with increasing severity of oxygen desaturation which could favour a positive energy balance.

  12. Vaccenic acid favourably alters immune function in obese JCR:LA-cp rats.

    Science.gov (United States)

    Blewett, Heather J; Gerdung, Christopher A; Ruth, Megan R; Proctor, Spencer D; Field, Catherine J

    2009-08-01

    Vaccenic acid (VA) is a ruminant-derived trans-fat and precursor of conjugated linoleic acid (CLA). The objective of the present study was to explore the effects of VA on immune function in a model of the metabolic syndrome, JCR:LA-cp rats. Lean (2:1 mix of +/cp and +/+) and obese (cp/cp) rats, aged 8 weeks, were fed a control (0% VA) or a VA diet (1.5% (w/w) VA) for 3 weeks (twenty rats per group). Splenocytes and mesenteric lymph node (MLN) immune cell phenotypes (flow cytometry), ex vivo cytokine production (ELISA) and phospholipid fatty acid concentrations were measured. Obese rats had higher proportions of splenic macrophages, total T-cells, helper T-cells (total and percentage CD25+), cytotoxic T-cells (total and percentage CD25+) and produced higher concentrations of IL-6 to concanavalin A (ConA) compared with lean rats. Obese rats had lower proportions of MLN T-cells, new T-cells (CD3+CD90+) and cytotoxic T-cells, but higher proportions of helper cells that were CD45RC+, CD25+ and CD4lo, and produced higher concentrations of IL-2, IL-10, interferon gamma and TNFalpha in response to ConA compared with lean rats. VA was higher in plasma phospholipids and both VA and CLA (cis-9, trans-11) were higher in MLN phospholipids compared with control-fed rats. Lean VA-fed rats had lower proportions of MLN and splenocyte CD45RC+ helper cells, and helper T-cells. Splenocytes from VA-fed rats produced 16-23% less IL-2, IL-10 and TNFalpha compared with controls. VA normalised production of MLN IL-2 and TNFalpha in obese rats to levels similar to those seen in lean rats. These results indicate that dietary VA favourably alters the pro-inflammatory tendency of mesenteric lymphocytes from JCR:LA-cp rats.

  13. Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population.

    Science.gov (United States)

    Oelmann, Simon; Nauck, Matthias; Völzke, Henry; Bahls, Martin; Friedrich, Nele

    2016-01-01

    Irisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations between irisin concentration and lipid profile are poorly understood. Therefore, this investigation aimed to evaluate potential associations between irisin and lipid levels in the general population. Data of 430 men and 537 women from the population-based Study of Health in Pomerania (SHIP-TREND) with available irisin and lipid concentrations were used. Analyses of variance, linear and logistic regression models adjusted for age, HBA1c, waist circumference, physical activity, smoking, alcohol consumption, systolic blood pressure, ALAT were calculated. We detected significantly inverse associations between irisin and circulating levels of total [beta coefficient 0.21 (standard error 0.08), p = 0.01], low-density cholesterol [-0.16 (0.07), p = 0.03] and triglycerides [-0.17 (0.08), p = 0.02] for men. Females without lipid lowering medication had an inverse association between irisin and total cholesterol [-0.12 (0.06), p = 0.05]. Further, male subjects with irisin concentrations in the third tertile had an increased odds for elevated low-density cholesterol [odds ratio 1.96 (95% confidence interval 1.07-3.48), p = 0.03) and triglyceride [1.95 (1.09-3.47), p = 0.02] levels, even after exclusion of subjects with lipid lowering medication. In addition, our data revealed an annual rhythm of serum irisin levels with peak levels arise in winter and summer months. This is the first investigation to report a significant association between circulating irisin and a favourable lipid profile in the general population. This may infer that higher irisin concentrations are associated with a reduced risk for non-communicable diseases.

  14. Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population.

    Directory of Open Access Journals (Sweden)

    Simon Oelmann

    Full Text Available Irisin is a myokine, which is mainly inversely associated with the risk for non-communicable diseases. Irisin improves cellular energy metabolism by uncoupling the mitochondrial respiratory chain resulting in increased energy expenditure using lipids. To date potential associations between irisin concentration and lipid profile are poorly understood. Therefore, this investigation aimed to evaluate potential associations between irisin and lipid levels in the general population.Data of 430 men and 537 women from the population-based Study of Health in Pomerania (SHIP-TREND with available irisin and lipid concentrations were used. Analyses of variance, linear and logistic regression models adjusted for age, HBA1c, waist circumference, physical activity, smoking, alcohol consumption, systolic blood pressure, ALAT were calculated.We detected significantly inverse associations between irisin and circulating levels of total [beta coefficient 0.21 (standard error 0.08, p = 0.01], low-density cholesterol [-0.16 (0.07, p = 0.03] and triglycerides [-0.17 (0.08, p = 0.02] for men. Females without lipid lowering medication had an inverse association between irisin and total cholesterol [-0.12 (0.06, p = 0.05]. Further, male subjects with irisin concentrations in the third tertile had an increased odds for elevated low-density cholesterol [odds ratio 1.96 (95% confidence interval 1.07-3.48, p = 0.03 and triglyceride [1.95 (1.09-3.47, p = 0.02] levels, even after exclusion of subjects with lipid lowering medication. In addition, our data revealed an annual rhythm of serum irisin levels with peak levels arise in winter and summer months.This is the first investigation to report a significant association between circulating irisin and a favourable lipid profile in the general population. This may infer that higher irisin concentrations are associated with a reduced risk for non-communicable diseases.

  15. Circadian rhythm of a Silene species favours nocturnal pollination and constrains diurnal visitation.

    Science.gov (United States)

    Prieto-Benítez, Samuel; Dötterl, Stefan; Giménez-Benavides, Luis

    2016-07-24

    Traits related to flower advertisement and reward sometimes vary in a circadian way, reflecting phenotypic specialization. However, specialized flowers are not necessarily restricted to specialized pollinators. This is the case of most Silene species, typically associated with diurnal or nocturnal syndromes of pollination but usually showing complex suites of pollinators. A Silene species with mixed floral features between diurnal and nocturnal syndromes was used to test how petal opening, nectar production, scent emission and pollination success correlate in a circadian rhythm, and whether this is influenced by environmental conditions. The effect of diurnal and nocturnal visitation rates on plant reproductive success is also explored in three populations, including the effect of the pollinating seed predator Hadena sancta KEY RESULTS: The result showed that repeated petal opening at dusk was correlated with nectar secretion and higher scent production during the night. However, depending on environmental conditions, petals remain opened for a while in the morning, when nectar and pollen still were available. Pollen deposition was similarly effective at night and in the morning, but less effective in the afternoon. These results were consistent with field studies. The circadian rhythm regulating floral attractiveness and reward in S. colorata is predominantly adapted to nocturnal flower visitors. However, favourable environmental conditions lengthen the optimal daily period of flower attraction and pollination towards morning. This allows the complementarity of day and night pollination. Diurnal pollination may help to compensate the plant reproductive success when nocturnal pollinators are scarce and when the net outcome of H. sancta shifts from mutualism to parasitism. These results suggest a functional mechanism explaining why the supposed nocturnal syndrome of many Silene species does not successfully predict their pollinator guilds. © The Author 2016

  16. 14 February 2012 - Ambassadors from Algeria, Brunei Darussalam, Canada, Chad, Tunisia, Permanent Representatives to the United Nations Office at Geneva in the LHC tunnel at Point 1, ATLAS visitor centre, and ATLAS underground experimental area, throughout accompanied by Advisers P. Fassnacht, E. Tsesmelis and R. Voss

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    14 February 2012 - Ambassadors from Algeria, Brunei Darussalam, Canada, Chad, Tunisia, Permanent Representatives to the United Nations Office at Geneva in the LHC tunnel at Point 1, ATLAS visitor centre, and ATLAS underground experimental area, throughout accompanied by Advisers P. Fassnacht, E. Tsesmelis and R. Voss

  17. Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males

    OpenAIRE

    Lovlie, H.; Gillingham, M. A. F.; WORLEY K; Pizzari, T.; Richardson, David

    2013-01-01

    Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus gallus, bias sperm use in favour of unrelated males. Here, we experimentally investigate whether this bias is driven by relatedness per se, or by similarity at the major histocompatibility complex (MHC), genes central to vertebrate acquired i...

  18. Subungual Squamous Cell Carcinoma Associated with Long Standing Onychomycosis: Aggressive Surgical Approach with a Favourable Outcome

    Directory of Open Access Journals (Sweden)

    Yavor Grigorov

    2017-07-01

    CONCLUSION: Although there are no available data in the literature to confirm or reject the contribution of the chronic nail infection to the malignant process, we emphasise the importance of this co-existence regarding the possible disguising of the malignant process. An early biopsy of a chronic persistent nail lesion may be preventive and beneficial regarding avoiding more aggressive treatments and achieving a favourable prognosis.

  19. Identifying the Environmental Conditions Favouring West Nile Virus Outbreaks in Europe

    OpenAIRE

    Marcantonio, Matteo; Rizzoli, Annapaola; Metz, Markus; Rosà, Roberto; Marini, Giovanni; Chadwick, Elizabeth Anna; Neteler, Markus

    2015-01-01

    West Nile Virus (WNV) is a globally important mosquito borne virus, with significant implications for human and animal health. The emergence and spread of new lineages, and increased pathogenicity, is the cause of escalating public health concern. Pinpointing the environmental conditions that favour WNV circulation and transmission to humans is challenging, due both to the complexity of its biological cycle, and the under-diagnosis and reporting of epidemiological data. Here, we used remote s...

  20. Tsunami run-up and inundation along the coast of Sabah and Sarawak, Malaysia due to a potential Brunei submarine mass failure.

    Science.gov (United States)

    Tan, Wai Kiat; Teh, Su Yean; Koh, Hock Lye

    2017-03-25

    Submarine landslides, also known as submarine mass failures (SMFs), are major natural marine disasters that could critically damage coastal facilities such as nuclear power plants and oil and gas platforms. It is therefore essential to investigate submarine landslides for potential tsunami hazard assessment. Three-dimensional seismic data from offshore Brunei have revealed a giant seabed mass deposited by a previous SMF. The submarine mass extends over 120 km from the continental slope of the Baram Canyon at 200 m water depth to the deep basin floor of the Northwest Borneo Trough. A suite of in-house two-dimensional depth-averaged tsunami simulation model TUNA (Tsunami-tracking Utilities and Application) is developed to assess the vulnerability of coastal communities in Sabah and Sarawak subject to potential SMF tsunami. The submarine slide is modeled as a rigid body moving along a planar slope with the center of mass motion parallel to the planar slope and subject to external forces due to added mass, gravity, and dissipation. The nonlinear shallow water equations are utilized to simulate tsunami propagation from deepwater up to the shallow offshore areas. A wetting-drying algorithm is used when a tsunami wave reaches the shoreline to compute run up of tsunami along the shoreline. Run-up wave height and inundation maps are provided for seven densely populated locations in Sabah and Sarawak to highlight potential risks at each location, subject to two scenarios of slide slopes: 2° and 4°. The first wave may arrive at Kudat as early as 0.4 h after the SMF, giving local communities little time to evacuate. Over a small area, maximum inundated depths reaching 20.3 m at Kudat, 26.1 m at Kota Kinabalu, and 15.5 m at Miri are projected, while the maximum inundation distance of 4.86 km is expected at Miri due to its low-lying coast. In view of the vulnerability of some locations to the SMF tsunami, it is important to develop and implement community resilience

  1. Women favour dyadic relationships, but men prefer clubs: cross-cultural evidence from social networking.

    Directory of Open Access Journals (Sweden)

    Tamas David-Barrett

    Full Text Available The ability to create lasting, trust-based friendships makes it possible for humans to form large and coherent groups. The recent literature on the evolution of sociality and on the network dynamics of human societies suggests that large human groups have a layered structure generated by emotionally supported social relationships. There are also gender differences in adult social style which may involve different trade-offs between the quantity and quality of friendships. Although many have suggested that females tend to focus on intimate relations with a few other females, while males build larger, more hierarchical coalitions, the existence of such gender differences is disputed and data from adults is scarce. Here, we present cross-cultural evidence for gender differences in the preference for close friendships. We use a sample of ∼112,000 profile pictures from nine world regions posted on a popular social networking site to show that, in self-selected displays of social relationships, women favour dyadic relations, whereas men favour larger, all-male cliques. These apparently different solutions to quality-quantity trade-offs suggest a universal and fundamental difference in the function of close friendships for the two sexes.

  2. Women favour dyadic relationships, but men prefer clubs: cross-cultural evidence from social networking.

    Science.gov (United States)

    David-Barrett, Tamas; Rotkirch, Anna; Carney, James; Behncke Izquierdo, Isabel; Krems, Jaimie A; Townley, Dylan; McDaniell, Elinor; Byrne-Smith, Anna; Dunbar, Robin I M

    2015-01-01

    The ability to create lasting, trust-based friendships makes it possible for humans to form large and coherent groups. The recent literature on the evolution of sociality and on the network dynamics of human societies suggests that large human groups have a layered structure generated by emotionally supported social relationships. There are also gender differences in adult social style which may involve different trade-offs between the quantity and quality of friendships. Although many have suggested that females tend to focus on intimate relations with a few other females, while males build larger, more hierarchical coalitions, the existence of such gender differences is disputed and data from adults is scarce. Here, we present cross-cultural evidence for gender differences in the preference for close friendships. We use a sample of ∼112,000 profile pictures from nine world regions posted on a popular social networking site to show that, in self-selected displays of social relationships, women favour dyadic relations, whereas men favour larger, all-male cliques. These apparently different solutions to quality-quantity trade-offs suggest a universal and fundamental difference in the function of close friendships for the two sexes.

  3. SIMPROVING THE ECONOMIC ACTIVITIES IN THE LESS FAVOURED AREAS OF ROMANIA

    Directory of Open Access Journals (Sweden)

    Tileaga Cosmin

    2011-07-01

    Full Text Available This paper deals with finding solutions for improving the economic activities in Romania’s undeveloped areas, which still represent a major problem for this country’s economy. During 1999 and 2009, these areas were considered tax havens, due to some facilities accorded by the Government and the EU (headage compensatory allowances*, tax deductions, non-refundable funds. Many had the opportunity to invest in those regions, but no positive effect was to be seen. Tulcea County (Danube Delta area, coal mine regions, rural areas and the North-East area (Suceava and Botosani county are considered to be Romania’s less favoured areas. * The objective of these schemes is to provide a reasonable level of income for farmers where natural production conditions are least favourable so as to conserve the countryside by the prevention of further depopulation of rural areas. Compensatory allowances are payable to farmers for the keeping of cattle, sheep and goats. (www.europa.eu

  4. Alterations in energy homeostasis to favour adipose tissue gain: A longitudinal study in healthy pregnant women.

    Science.gov (United States)

    Abeysekera, Minoli V; Morris, Jack A; Davis, Gregory K; O'Sullivan, Anthony J

    2016-02-01

    Pregnancy is associated with an increase in body fat; however, excessive gestational weight gain predisposes to significant maternal and neonatal morbidity and mortality. It remains unclear whether alterations in energy homeostasis have a major influence on fat storage. To evaluate longitudinal changes in body composition and energy metabolism in healthy pregnant women. Body composition, energy expenditure and energy intake were measured longitudinally in 26 women with singleton pregnancies at 12-14 weeks, 24-26 weeks and 34-36 weeks of gestation. Fat mass (FM) and lean body mass (LBM) were measured using bio-impedance analysis, total energy expenditure (TEE) using the Sensewear Armband and energy intake through a 3-day food recall diary. Throughout pregnancy, all women remained healthy. Body weight increased by 10.8 ± 3.9 kg, from 67.3 ± 14.1 kg to 78.1 ± 13.8 kg from the first to the third trimester (P Body fat percentage increased by 4.5 ± 4.2% (P change significantly throughout pregnancy. Healthy women increase FM during pregnancy despite slight increases in TEE and no change in energy intake. This suggests that energy storage efficiency improves during pregnancy, which may be related to alterations in gut microbiota and activation of anabolic pathways during pregnancy. Clarifying factors leading to this more efficient fat and energy storing state, and the role of the pregnancy-related changes in gut microbiota, may be important for managing gestational weight gain. © 2015 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

  5. Soft Gamma-ray selected radio galaxies: favouring giant size discovery

    Science.gov (United States)

    Panessa, Francesca; Bassani, Loredana

    2016-07-01

    Using the recent INTEGRAL/IBIS and Swift/BAT surveys we have extracted a sample of radio galaxies selected in the soft gamma-ray band. The sample consists of known and candidate radio galaxies. The sample extraction criteria will be presented and its general properties outlined. In particular we provide strong evidence that this soft gamma-ray selection favours the discovery of large size radio objects, otherwise known as Giant Radio Galaxies or GRG. The main reasons and/or conditions leading to the formation of these sources are still unclear and this result suggests that they maybe related to exceptional internal properties of the source central engine, like a high jet power or a long activity time. Broad band analysis of new GRG, discovered during this work, will also be presented.

  6. Training information service specialists in the less favoured regions of the European Union (TRAIN-ISS

    Directory of Open Access Journals (Sweden)

    I. Owens

    1996-01-01

    Full Text Available The expanding information infrastructure in Europe will increase the demand for high-quality, easily accessible and usable information services. At the same time, in the Information Society, there will be an increasing demand for professionals with skills, able to improve their potential through life long learning, accessing and using information sources available world-wide. Highly qualified information professionals are a crucial asset in any society to enable it to reap all the benefits and opportunities created by the Information Market. In the Less Favoured Regions (LFRs of the European Union there is a shortage of education and training opportunities for information professionals to enable them to cope with the rapidly changing environment. It was to address this need for well qualified and trained information professionals that the TRAIN-ISS project was funded under the IMPACT 2 programme of the Commission of the European Communities

  7. Autistic regression with and without EEG abnormalities followed by favourable outcome.

    Science.gov (United States)

    Zappella, Michele

    2010-10-01

    To explore the relationship between autistic regression (AR) with and without EEG abnormalities and favourable outcome. Follow up data on children with favourable outcome in a series of 534 cases aged below 5 years and diagnosed as ASD. Cases with regression were 167 (31.8%), usually with persistent ASD, intellectual disabilities and EEG abnormalities. Thirty nine children (7.3%) went off autism and recovered entirely their intellectual and social abilities. Few of them included examples of pharmacologically treated Landau and Kleffner syndrome and other similar complex cases with abnormal EEG. The majority was represented by 36 (6.7%) children, mostly males, with a dysmaturational syndrome: their development was initially normal up to 18 months when an autistic regression occurred accompanied by the appearance of motor and vocal tics. Relational therapies were followed by rapid improvement. By 6 years all children had lost features of ASD and their I.Q. was in most cases between 90 and 110. Convulsions were absent and EEG was normal in all cases except one. In a few of them recovery was spontaneous. Seventeen children were followed after 5 years 6 months: 12 (70%) had ADHD, 10 (56%) persistent tics. Tics were often present in parents and relatives, ASD absent, suggesting a genetic background different from cases with persistent ASD. With one exception all "off autism" children had a previous autistic regression. In this series "off autism" children had either early onset epilepsy and/or EEG abnormalities or cases of dysmaturational syndrome. Autistic regression was present in almost all. Copyright © 2010. Published by Elsevier B.V.

  8. Future climate change will favour non-specialist mammals in the (sub)arctics.

    Science.gov (United States)

    Hof, Anouschka R; Jansson, Roland; Nilsson, Christer

    2012-01-01

    Arctic and subarctic (i.e., [sub]arctic) ecosystems are predicted to be particularly susceptible to climate change. The area of tundra is expected to decrease and temperate climates will extend further north, affecting species inhabiting northern environments. Consequently, species at high latitudes should be especially susceptible to climate change, likely experiencing significant range contractions. Contrary to these expectations, our modelling of species distributions suggests that predicted climate change up to 2080 will favour most mammals presently inhabiting (sub)arctic Europe. Assuming full dispersal ability, most species will benefit from climate change, except for a few cold-climate specialists. However, most resident species will contract their ranges if they are not able to track their climatic niches, but no species is predicted to go extinct. If climate would change far beyond current predictions, however, species might disappear. The reason for the relative stability of mammalian presence might be that arctic regions have experienced large climatic shifts in the past, filtering out sensitive and range-restricted taxa. We also provide evidence that for most (sub)arctic mammals it is not climate change per se that will threaten them, but possible constraints on their dispersal ability and changes in community composition. Such impacts of future changes in species communities should receive more attention in literature.

  9. Future climate change will favour non-specialist mammals in the (subarctics.

    Directory of Open Access Journals (Sweden)

    Anouschka R Hof

    Full Text Available Arctic and subarctic (i.e., [sub]arctic ecosystems are predicted to be particularly susceptible to climate change. The area of tundra is expected to decrease and temperate climates will extend further north, affecting species inhabiting northern environments. Consequently, species at high latitudes should be especially susceptible to climate change, likely experiencing significant range contractions. Contrary to these expectations, our modelling of species distributions suggests that predicted climate change up to 2080 will favour most mammals presently inhabiting (subarctic Europe. Assuming full dispersal ability, most species will benefit from climate change, except for a few cold-climate specialists. However, most resident species will contract their ranges if they are not able to track their climatic niches, but no species is predicted to go extinct. If climate would change far beyond current predictions, however, species might disappear. The reason for the relative stability of mammalian presence might be that arctic regions have experienced large climatic shifts in the past, filtering out sensitive and range-restricted taxa. We also provide evidence that for most (subarctic mammals it is not climate change per se that will threaten them, but possible constraints on their dispersal ability and changes in community composition. Such impacts of future changes in species communities should receive more attention in literature.

  10. De-novo CD5 + B- prolymphocytic leukemia (PLL) presenting at younger age with favourable outcome.

    Science.gov (United States)

    Kar, Rakhee; Kumar, Rajat; Tyagi, Seema

    2008-09-05

    B-cell prolymphocytic leukemia (B-PLL) comprises 1% of chronic lymphocytic leukemias. CD5 positivity is seen in 1/3rd of cases which generally arise from pre existing CLL. They have longer median survival compared with de novo B-PLL which are commonly CD5 negative and are more aggressive with an older age of presentation. Herewith, we describe a 48-year-old male of de-novo CD5+ B-PLL presenting with minimal lymphadenopathy and massive splenomegaly with 90% atypical lymphoid cells in the peripheral smear and bone marrow. Immunophenotyping was strongly positive for CD5, CD45, CD19, CD22, FMC-7, S-Ig and CD38, moderately positive for CD 11c, weakly positive for CD23 and negative for CD-103 and ZAP 70. The patient responded well to fludarabine and cyclophosphamide and had an uneventful hospital course. Our case illustrates a de-novo B-PLL with aberrant CD5 positivity who had a short duration of illness, younger age at presentation and favourable treatment outcome.

  11. Cryptic female choice favours sperm from major histocompatibility complex-dissimilar males.

    Science.gov (United States)

    Løvlie, Hanne; Gillingham, Mark A F; Worley, Kirsty; Pizzari, Tommaso; Richardson, David S

    2013-10-22

    Cryptic female choice may enable polyandrous females to avoid inbreeding or bias offspring variability at key loci after mating. However, the role of these genetic benefits in cryptic female choice remains poorly understood. Female red junglefowl, Gallus gallus, bias sperm use in favour of unrelated males. Here, we experimentally investigate whether this bias is driven by relatedness per se, or by similarity at the major histocompatibility complex (MHC), genes central to vertebrate acquired immunity, where polymorphism is critical to an individual's ability to combat pathogens. Through experimentally controlled natural matings, we confirm that selection against related males' sperm occurs within the female reproductive tract but demonstrate that this is more accurately predicted by MHC similarity: controlling for relatedness per se, more sperm reached the eggs when partners were MHC--dissimilar. Importantly, this effect appeared largely owing to similarity at a single MHC locus (class I minor). Further, the effect of MHC similarity was lost following artificial insemination, suggesting that male phenotypic cues might be required for females to select sperm differentially. These results indicate that postmating mechanisms that reduce inbreeding may do so as a consequence of more specific strategies of cryptic female choice promoting MHC diversity in offspring.

  12. Soft Gamma-ray selected radio galaxies: favouring giant size discovery

    CERN Document Server

    Bassani, L; Molina, M; Malizia, A; Dallacasa, D; Panessa, F; Bazzano, A; Ubertini, P

    2016-01-01

    Using the recent INTEGRAL/IBIS and Swift/BAT surveys we have extracted a sample of 64 confirmed plus 3 candidate radio galaxies selected in the soft gamma-ray band. The sample covers all optical classes and is dominated by objects showing a FR II radio morphology; a large fraction (70%) of the sample is made of radiative mode or High Excitation Radio Galaxies (HERG). We have measured the source size on NVSS, FIRST and SUMSS images and have compared our findings with data in the literature obtaining a good match. We surprisingly found that the soft gamma-ray selection favours the detection of large size radio galaxies: 60% of objects in the sample have size greater than 0.4 Mpc while around 22% reach dimension above 0.7 Mpc at which point they are classified as Giant Radio Galaxies or GRGs, the largest and most energetic single entities in the Universe. Their fraction among soft gamma ray selected radio galaxies is significantly larger than typically found in radio surveys, where only a few percent of objects ...

  13. Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity.

    Science.gov (United States)

    Guerau-de-Arellano, Mireia; Smith, Kristen M; Godlewski, Jakub; Liu, Yue; Winger, Ryan; Lawler, Sean E; Whitacre, Caroline C; Racke, Michael K; Lovett-Racke, Amy E

    2011-12-01

    Pro-inflammatory T cells mediate autoimmune demyelination in multiple sclerosis. However, the factors driving their development and multiple sclerosis susceptibility are incompletely understood. We investigated how micro-RNAs, newly described as post-transcriptional regulators of gene expression, contribute to pathogenic T-cell differentiation in multiple sclerosis. miR-128 and miR-27b were increased in naïve and miR-340 in memory CD4(+) T cells from patients with multiple sclerosis, inhibiting Th2 cell development and favouring pro-inflammatory Th1 responses. These effects were mediated by direct suppression of B lymphoma Mo-MLV insertion region 1 homolog (BMI1) and interleukin-4 (IL4) expression, resulting in decreased GATA3 levels, and a Th2 to Th1 cytokine shift. Gain-of-function experiments with these micro-RNAs enhanced the encephalitogenic potential of myelin-specific T cells in experimental autoimmune encephalomyelitis. In addition, treatment of multiple sclerosis patient T cells with oligonucleotide micro-RNA inhibitors led to the restoration of Th2 responses. These data illustrate the biological significance and therapeutic potential of these micro-RNAs in regulating T-cell phenotypes in multiple sclerosis.

  14. Physiological responses to increased brood size and ectoparasite infestation: Adult great tits favour self-maintenance.

    Science.gov (United States)

    Wegmann, Michele; Voegeli, Beatrice; Richner, Heinz

    2015-03-15

    Different types of stressors trigger responses of different physiological systems, and these responses may contribute differentially to the maintenance of homeostasis, to trade-offs and the evolution of life-history traits. To manipulate two common stressors during reproduction, we infested half of the nests in a naturally breeding great tit population with ectoparasites and simultaneously manipulated brood size, using a 2×2 experimental design. Parents in this model species commonly compensate for ectoparasites by an increase in food provisioning. We assessed parental responses to these concurrent stressors by measuring several physiological stress parameters such as changes in metabolic rate, oxidative stress and expression of heat-shock proteins (Hsp), and explored how these stressors affect the trade-off between self-maintenance and reproduction. Neither flea infestation nor brood size manipulation affected adult metabolic rate, oxidative damage or Hsp levels. Furthermore, we found no interactive effect of the two treatments on adults. However, nestlings in infested nests had lower body mass and lower survival. Nestlings in enlarged broods were lighter and had lower survival, although parents of enlarged broods increased food provisioning rate. The findings suggest that adults favour maintenance of cellular homeostasis, and physiological equilibrium over current reproduction, and that the costs induced by both stressors, flea infestation and increased brood size, are carried by the offspring. It emphasizes the importance of self-maintenance over reproduction in life-history decisions, and more generally the need of including physiological traits for understanding the evolution of life-histories.

  15. Identifying the environmental conditions favouring West Nile Virus outbreaks in Europe.

    Directory of Open Access Journals (Sweden)

    Matteo Marcantonio

    Full Text Available West Nile Virus (WNV is a globally important mosquito borne virus, with significant implications for human and animal health. The emergence and spread of new lineages, and increased pathogenicity, is the cause of escalating public health concern. Pinpointing the environmental conditions that favour WNV circulation and transmission to humans is challenging, due both to the complexity of its biological cycle, and the under-diagnosis and reporting of epidemiological data. Here, we used remote sensing and GIS to enable collation of multiple types of environmental data over a continental spatial scale, in order to model annual West Nile Fever (WNF incidence across Europe and neighbouring countries. Multi-model selection and inference were used to gain a consensus from multiple linear mixed models. Climate and landscape were key predictors of WNF outbreaks (specifically, high precipitation in late winter/early spring, high summer temperatures, summer drought, occurrence of irrigated croplands and highly fragmented forests. Identification of the environmental conditions associated with WNF outbreaks is key to enabling public health bodies to properly focus surveillance and mitigation of West Nile virus impact, but more work needs to be done to enable accurate predictions of WNF risk.

  16. Identifying the environmental conditions favouring West Nile Virus outbreaks in Europe.

    Science.gov (United States)

    Marcantonio, Matteo; Rizzoli, Annapaola; Metz, Markus; Rosà, Roberto; Marini, Giovanni; Chadwick, Elizabeth; Neteler, Markus

    2015-01-01

    West Nile Virus (WNV) is a globally important mosquito borne virus, with significant implications for human and animal health. The emergence and spread of new lineages, and increased pathogenicity, is the cause of escalating public health concern. Pinpointing the environmental conditions that favour WNV circulation and transmission to humans is challenging, due both to the complexity of its biological cycle, and the under-diagnosis and reporting of epidemiological data. Here, we used remote sensing and GIS to enable collation of multiple types of environmental data over a continental spatial scale, in order to model annual West Nile Fever (WNF) incidence across Europe and neighbouring countries. Multi-model selection and inference were used to gain a consensus from multiple linear mixed models. Climate and landscape were key predictors of WNF outbreaks (specifically, high precipitation in late winter/early spring, high summer temperatures, summer drought, occurrence of irrigated croplands and highly fragmented forests). Identification of the environmental conditions associated with WNF outbreaks is key to enabling public health bodies to properly focus surveillance and mitigation of West Nile virus impact, but more work needs to be done to enable accurate predictions of WNF risk.

  17. Amplified mid-latitude planetary waves favour particular regional weather extremes

    Science.gov (United States)

    Screen, James A.; Simmonds, Ian

    2014-08-01

    There has been an ostensibly large number of extreme weather events in the Northern Hemisphere mid-latitudes during the past decade. An open question that is critically important for scientists and policy makers is whether any such increase in weather extremes is natural or anthropogenic in origin. One mechanism proposed to explain the increased frequency of extreme weather events is the amplification of mid-latitude atmospheric planetary waves. Disproportionately large warming in the northern polar regions compared with mid-latitudes--and associated weakening of the north-south temperature gradient--may favour larger amplitude planetary waves, although observational evidence for this remains inconclusive. A better understanding of the role of planetary waves in causing mid-latitude weather extremes is essential for assessing the potential environmental and socio-economic impacts of future planetary wave changes. Here we show that months of extreme weather over mid-latitudes are commonly accompanied by significantly amplified quasi-stationary mid-tropospheric planetary waves. Conversely, months of near-average weather over mid-latitudes are often accompanied by significantly attenuated waves. Depending on geographical region, certain types of extreme weather (for example, hot, cold, wet, dry) are more strongly related to wave amplitude changes than others. The findings suggest that amplification of quasi-stationary waves preferentially increases the probabilities of heat waves in western North America and central Asia, cold outbreaks in eastern North America, droughts in central North America, Europe and central Asia, and wet spells in western Asia.

  18. January 2016 extensive summer melt in West Antarctica favoured by strong El Niño

    Science.gov (United States)

    Nicolas, Julien P.; Vogelmann, Andrew M.; Scott, Ryan C.; Wilson, Aaron B.; Cadeddu, Maria P.; Bromwich, David H.; Verlinde, Johannes; Lubin, Dan; Russell, Lynn M.; Jenkinson, Colin; Powers, Heath H.; Ryczek, Maciej; Stone, Gregory; Wille, Jonathan D.

    2017-06-01

    Over the past two decades the primary driver of mass loss from the West Antarctic Ice Sheet (WAIS) has been warm ocean water underneath coastal ice shelves, not a warmer atmosphere. Yet, surface melt occurs sporadically over low-lying areas of the WAIS and is not fully understood. Here we report on an episode of extensive and prolonged surface melting observed in the Ross Sea sector of the WAIS in January 2016. A comprehensive cloud and radiation experiment at the WAIS ice divide, downwind of the melt region, provided detailed insight into the physical processes at play during the event. The unusual extent and duration of the melting are linked to strong and sustained advection of warm marine air toward the area, likely favoured by the concurrent strong El Niño event. The increase in the number of extreme El Niño events projected for the twenty-first century could expose the WAIS to more frequent major melt events.

  19. Relax and refill: xylem rehydration prior to hydraulic measurements favours embolism repair in stems and generates artificially low PLC values.

    Science.gov (United States)

    Trifilò, Patrizia; Raimondo, Fabio; Lo Gullo, Maria A; Barbera, Piera M; Salleo, Sebastiano; Nardini, Andrea

    2014-11-01

    Diurnal changes in percentage loss of hydraulic conductivity (PLC), with recorded values being higher at midday than on the following morning, have been interpreted as evidence for the occurrence of cycles of xylem conduits' embolism and repair. Recent reports have suggested that diurnal PLC changes might arise as a consequence of an experimental artefact, that is, air entry into xylem conduits upon cutting stems, even if under water, while under substantial tension generated by transpiration. Rehydration procedures prior to hydraulic measurements have been recommended to avoid this artefact. In the present study, we show that xylem rehydration prior to hydraulic measurements might favour xylem refilling and embolism repair, thus leading to PLC values erroneously lower than those actually experienced by transpiring plants. When xylem tension relaxation procedures were performed on stems where refilling mechanisms had been previously inhibited by mechanical (girdling) or chemical (orthovanadate) treatment, PLC values measured in stems cut under native tension were the same as those measured after sample rehydration/relaxation. Our data call for renewed attention to the procedures of sample collection in the field and transport to the laboratory, and suggest that girdling might be a recommendable treatment prior to sample collection for PLC measurements.

  20. Organic farming favours insect-pollinated over non-insect pollinated forbs in meadows and wheat fields.

    Science.gov (United States)

    Batáry, Péter; Sutcliffe, Laura; Dormann, Carsten F; Tscharntke, Teja

    2013-01-01

    The aim of this study was to determine the relative effects of landscape-scale management intensity, local management intensity and edge effect on diversity patterns of insect-pollinated vs. non-insect pollinated forbs in meadows and wheat fields. Nine landscapes were selected differing in percent intensively used agricultural area (IAA), each with a pair of organic and conventional winter wheat fields and a pair of organic and conventional meadows. Within fields, forbs were surveyed at the edge and in the interior. Both diversity and cover of forbs were positively affected by organic management in meadows and wheat fields. This effect, however, differed significantly between pollination types for species richness in both agroecosystem types (i.e. wheat fields and meadows) and for cover in meadows. Thus, we show for the first time in a comprehensive analysis that insect-pollinated plants benefit more from organic management than non-insect pollinated plants regardless of agroecosystem type and landscape complexity. These benefits were more pronounced in meadows than wheat fields. Finally, the community composition of insect-pollinated and non-insect-pollinated forbs differed considerably between management types. In summary, our findings in both agroecosystem types indicate that organic management generally supports a higher species richness and cover of insect-pollinated plants, which is likely to be favourable for the density and diversity of bees and other pollinators.

  1. The evolution of colour pattern complexity: selection for conspicuousness favours contrasting within-body colour combinations in lizards.

    Science.gov (United States)

    Pérez I de Lanuza, G; Font, E

    2016-05-01

    Many animals display complex colour patterns that comprise several adjacent, often contrasting colour patches. Combining patches of complementary colours increases the overall conspicuousness of the complex pattern, enhancing signal detection. Therefore, selection for conspicuousness may act not only on the design of single colour patches, but also on their combination. Contrasting long- and short-wavelength colour patches are located on the ventral and lateral surfaces of many lacertid lizards. As the combination of long- and short-wavelength-based colours generates local chromatic contrast, we hypothesized that selection may favour the co-occurrence of lateral and ventral contrasting patches, resulting in complex colour patterns that maximize the overall conspicuousness of the signal. To test this hypothesis, we performed a comparative phylogenetic study using a categorical colour classification based on spectral data and descriptive information on lacertid coloration collected from the literature. Our results demonstrate that conspicuous ventral (long-wavelength-based) and lateral (short-wavelength-based) colour patches co-occur throughout the lacertid phylogeny more often than expected by chance, especially in the subfamily Lacertini. These results suggest that selection promotes the evolution of the complex pattern rather than the acquisition of a single conspicuous colour patch, possibly due to the increased conspicuousness caused by the combination of colours with contrasting spectral properties.

  2. A novel organometallic ReI complex with favourable properties for bioimaging and applicability in solid-phase peptide synthesis.

    Science.gov (United States)

    Raszeja, Lukasz; Maghnouj, Abdelouahid; Hahn, Stephan; Metzler-Nolte, Nils

    2011-02-11

    Organometallic complexes possess great potential for imaging applications in biology, due to their kinetic stability and often favourable intrinsic properties. In this work we present a new class of Re(I) -tricarbonyl complexes with a substituted bis(phenanthridinylmethyl)amine (bpm) ligand. The complex Re(CO)(3) (R-bpm) could be conveniently prepared by microwave synthesis from [Re(CO)(3)(H(2)O)(3) ]Br and a suitably substituted bis(phenanthridinylmethyl)amine (R-bpm). Complex 5, with R=CH(2)-CO(2)-CH(3) , was characterized by a single-crystal X-ray structure. Complex 6 (R=CH(2)-C(6)H(4)-CO(2)H) was used in solid-phase peptide synthesis (SPPS) to label the neurotensin(8-13) (NT) fragment N-terminally. The complexes show luminescence emission with large Stokes shifts (λ(ex) =350 nm, λ(em) =570 nm). Cellular uptake and intracellular localization studies in several cell lines demonstrate the utility of the new Re(CO)(3) (R-bpm) complexes for fluorescence imaging and reveal significant differences between the simple methyl ester 5 and the NT bioconjugate 7.

  3. Testing the efficacy of downscaling in species distribution modelling: a comparison between MaxEnt and Favourability Function models

    Energy Technology Data Exchange (ETDEWEB)

    Olivero, J.; Toxopeus, A.G.; Skidmore, A.K.; Real, R.

    2016-07-01

    Statistical downscaling is used to improve the knowledge of spatial distributions from broad–scale to fine–scale maps with higher potential for conservation planning. We assessed the effectiveness of downscaling in two commonly used species distribution models: Maximum Entropy (MaxEnt) and the Favourability Function (FF). We used atlas data (10 x 10 km) of the fire salamander Salamandra salamandra distribution in southern Spain to derive models at a 1 x 1 km resolution. Downscaled models were assessed using an independent dataset of the species’ distribution at 1 x 1 km. The Favourability model showed better downscaling performance than the MaxEnt model, and the models that were based on linear combinations of environmental variables performed better than models allowing higher flexibility. The Favourability model minimized model overfitting compared to the MaxEnt model. (Author)

  4. Favourable areas for expansion and reintroduction of Iberian lynx accounting for distribution trends and genetic variation of the wild rabbit

    Directory of Open Access Journals (Sweden)

    A. Márcia Barbosa

    2010-12-01

    Full Text Available Although on a local scale Iberian lynx distribution is determined by the availability of prey rabbits, recent modelling analyses have uncovered broad-scale disagreements between these two species’ distribution trends. These analyses showed also that the lynx had become restricted to only a fraction of the rabbit’s genetic variability, and that this could be jeopardising its survival in the face of environmental hazards and uncertainty. In the present paper, a follow-up was carried out through the building of lynx and rabbit distribution models based on the most recent Spanish mammal atlas. The predictions of environmental favourability (which is an indicator of abundance for lynx and rabbit were positively correlated within the lynx's current distribution area, but they were negatively correlated within the total Spanish area where lynx occurred in the 1980’s. Environmental favourability for rabbits was significantly higher where lynx maintains reproductive populations than where it recently disappeared, indicating that rabbit favourability plays an important role and can be a good predictor of lynx persistence. The lynx and rabbit models were extrapolated to predict favourable areas for both species in Spain as well as in Portugal, on the original scale of the distribution data (10x10 km and on a 100 times finer spatial resolution (1x1 km. The lynx and rabbit models were also combined through fuzzy logic to forecast the potential for lynx occurrence incorporating information on favourable areas for its main prey. Several areas are proposed as favourable for lynx expansion or re-introduction, encompassing both countries and both genetic lineages of the rabbit.

  5. Higher maternal education is associated with favourable growth of young children in different countries

    Science.gov (United States)

    Lakshman, Rajalakshmi; Zhang, Jing; Zhang, Jianduan; Koch, Felix S; Marcus, Claude; Ludvigsson, Johnny; Ong, Ken K; Sobko, Tanja

    2013-01-01

    Background Childhood growth affects long-term health and could contribute to health inequalities that persist throughout life. Methods We compared growth data of 4-6 year old children born 1997-2002 in UK (n=15,168), Sweden (n=6,749) and rural China (n=10,327). Standard deviation scores (SDS) were calculated against the WHO Standard. Obesity and overweight were defined by International Obesity Taskforce cut-offs, and stunting, underweight and thinness by height, weight or BMI < −2 SDS. Associations with maternal education were standardised by calculating the Slope Index of Inequality (SII). Results Mean SDS height, weight and BMI in UK (−0.01; 0.42; 0.62, respectively) and Sweden (0.45; 0.59; 0.45) were higher than in China (−0.98, −0.82, −0.29). Higher maternal education was consistently associated with taller offspring height SDS (SII: UK 0.25; Sweden 0.17; China 1.06). Underweight and stunting were less common in UK (prevalence: 0.6% and 2.2%, respectively) and Sweden (0.3% and 0.6%) than in China (9.5% and 16.4%), where these outcomes were inversely associated with maternal education (SII: −25.8% and −12.7%). Obesity prevalence in UK, Sweden and China was 4.8%, 3.7% and 0.4%, respectively. Maternal education was inversely associated with offspring obesity in UK (SII: −3.3%) and Sweden (−2.8%), but not in China (+0.3%). Conclusions Higher maternal education was associated with more favourable growth in young children: lower obesity and overweight in UK and Sweden, and lower stunting and underweight in rural China. Public health strategies to optimize growth in early childhood need to acknowledge socioeconomic factors, but possibly with a different emphasis in different settings. PMID:23450064

  6. Harmful and favourable ultraviolet conditions for human health over Northern Eurasia

    Science.gov (United States)

    Chubarova, Nataly; Zhdanova, Ekaterina

    2014-05-01

    We provide the analysis of the spatial and temporal distribution of ultraviolet (UV) radiation over Northern Eurasia taking into account for both its detrimental (erythema and eye-damage effects) and favourable (vitamin D synthesis) influence on human health. The UV effects on six different skin types are considered in order to cover the variety of skin types of European and Asian inhabitants. To better quantifying the vitamin D irradiance threshold we accounted for an open body fraction S as a function of effective air temperature. The spatial and temporal distribution of UV resources was estimated by radiative transfer (RT) modeling (8 stream DISORT RT code) with 1x 1 degree grid and monthly resolution. For this purpose special datasets of main input geophysical parameters (total ozone content, aerosol characteristics, surface UV albedo, UV cloud modification factor) have been created over the territory of Northern Eurasia, which can be of separate interest for the different multidisciplinary scientific applications over the PEEX domain. The new approaches were used to retrieve aerosol and cloud transmittance from different satellite and re-analysis datasets for calculating the solar UV irradiance at ground. Using model simulations and some experimental data we provide the altitude parameterization for different types of biologically active irradiance in mountainous area taking into account not only for the effects of molecular scattering but for the altitude dependence of aerosol parameters and surface albedo. Based on the new classification of UV resources (Chubarova, Zhdanova, 2013) we show that the distribution of harmful (UV deficiency and UV excess) and favorable UV conditions is regulated by various geophysical parameters (mainly, total ozone, cloudiness and open body fraction) and can significantly deviate from latitudinal dependence. The interactive tool for providing simulations of biologically active irradiance and its attribution to the different

  7. Heterosis may result in selection favouring the products of long-distance pollen dispersal in Eucalyptus.

    Directory of Open Access Journals (Sweden)

    João Costa E Silva

    Full Text Available Using native trees from near the northern and southern extremities of the relatively continuous eastern distribution of Eucalyptus globulus in Tasmania, we compared the progenies derived from natural open-pollination (OP with those generated from within-region and long-distance outcrossing. Controlled outcrossing amongst eight parents - with four parents from each of the northern and southern regions - was undertaken using a diallel mating scheme. The progeny were planted in two field trials located within the species native range in southern Tasmania, and their survival and diameter growth were monitored over a 13-year-period. The survival and growth performances of all controlled cross types exceeded those of the OP progenies, consistent with inbreeding depression due to a combination of selfing and bi-parental inbreeding. The poorer survival of the northern regional (♀N♂N outcrosses compared with the local southern regional outcrosses (♀S♂S indicated differential selection against the former. Despite this mal-adaptation of the non-local ♀N♂N crosses at both southern sites, the survival of the inter-regional hybrids (♀N♂S and ♀S♂N was never significantly different from that of the local ♀S♂S crosses. Significant site-dependent heterosis was detected for the growth of the surviving long-distance hybrids. This was expressed as mid-parent heterosis, particularly at the more northern planting site. Heterosis increased with age, while the difference between the regional ♀N♂N and ♀S♂S crosses remained insignificant at any age at either site. Nevertheless, the results for growth suggest that the fitness of individuals derived from long-distance crossing may be better at the more northern of the planting sites. Our results demonstrate the potential for early-age assessments of pollen dispersal to underestimate realised gene flow, with local inbreeding under natural open-pollination resulting in selection favouring the

  8. The effects of defoliation on carbon allocation: can carbon limitation reduce growth in favour of storage?

    Science.gov (United States)

    Wiley, Erin; Huepenbecker, Sarah; Casper, Brenda B; Helliker, Brent R

    2013-11-01

    There is no consensus about how stresses such as low water availability and temperature limit tree growth. Sink limitation to growth and survival is often inferred if a given stress does not cause non-structural carbohydrate (NSC) concentrations or levels to decline along with growth. However, trees may actively maintain or increase NSC levels under moderate carbon stress, making the pattern of reduced growth and increased NSCs compatible with carbon limitation. To test this possibility, we used full and half defoliation to impose severe and moderate carbon limitation on 2-year-old Quercus velutina Lam. saplings grown in a common garden. Saplings were harvested at either 3 weeks or 4 months after treatments were applied, representing short- and longer-term effects on woody growth and NSC levels. Both defoliation treatments maintained a lower total leaf area than controls throughout the experiment with no evidence of photosynthetic up-regulation, and resulted in a similar total biomass reduction. While fully defoliated saplings had lower starch levels than controls in the short term, half defoliated saplings maintained control starch levels in both the short and longer term. In the longer term, fully defoliated saplings had the greatest starch concentration increment, allowing them to recover to near-control starch levels. Furthermore, between the two harvest dates, fully and half defoliated saplings allocated a greater proportion of new biomass to starch than did controls. The maintenance of control starch levels in half defoliated saplings indicates that these trees actively store a substantial amount of carbon before growth is carbon saturated. In addition, the allocation shift favouring storage in defoliated saplings is consistent with the hypothesis that, as an adaptation to increasing carbon stress, trees can prioritize carbon reserve formation at the expense of growth. Our results suggest that as carbon limitation increases, reduced growth is not necessarily

  9. Does the Higgs mechanism favour electron-electron bound states in Maxwell-Chern-Simons $QED_{3}$?

    CERN Document Server

    Belich, H; Helayël-Neto, José A

    2000-01-01

    The low-energy electron-electron scattering potential is derived and discussed for the Maxwell-Chern-Simons model coupled to QED_3 with spontaneous symmetry breaking. One shows that the Higgs mechanism might favour electron-electron bound states.

  10. The role of EU agri-environmental measures preserving extensive grazing in two less-favoured areas in Portugal

    NARCIS (Netherlands)

    Jones, Nádia; Duarte, Filomena; Rodrigo, Isabel; Doorn, van Anne; Graaff, de Jan

    2016-01-01

    Since 1992 agri-environmental issues have gained attention by reforms of the CAP. For instance by supporting environmentally friendly land use, such as permanent pastures in less-favoured areas (LFA) that are only marginally suitable for alternative farming practices. In the last two decades a si

  11. Putative IL-10 Low Producer Genotypes Are Associated with a Favourable Etanercept Response in Patients with Rheumatoid Arthritis.

    Directory of Open Access Journals (Sweden)

    Heiko Schotte

    Full Text Available Outcome predictors of biologic therapeutic drugs like TNF inhibitors are of interest since side effects like serious infections or malignancy cannot be completely ruled out. Response rates are heterogeneous. The present study addressed the question whether in patients with rheumatoid arthritis (RA interleukin-10 (IL-10 promoter genotypes with potential relevance for IL-10 production capacity are associated with response to long-term treatment with etanercept. Caucasian RA patients that, according to the EULAR criteria, responded well (n = 25, moderately (n = 17 or not (n = 8 to etanercept therapy (median 36 months, range 4-52, and 160 matched controls were genotyped for the IL-10 promoter SNPs -2849 G>A (rs6703630, -1082 G>A (rs1800896, -819 C>T (rs1800871 and -592 C>A (rs1800872. Haplotypes were reconstructed via mathematic model and tested for associations with disease susceptibility and therapy response. We identified the four predominant haplotypes AGCC, GATA, GGCC, and GACC in almost equal distribution. Patients that responded well carried the putative IL-10 low producer allele -2849 A or the haplotypes AGCC and GATA (RR 2.1 and 4.0, respectively; 95% CI 1.1-4.0 and 1.1-14.8, whereas an unfavourable response was associated with carriage of the putative high producer haplotype GGCC (RR 1.9, 95% CI 1.1-3.3. No significant associations of alleles or haplotypes with disease susceptibility were observed. In RA, a low IL-10 production which is genetically determined rather by haplotypes than by SNPs may favour the response to etanercept treatment. Iatrogenic blockade of TNF may reveal proinflammatory effects of its endogeneous antagonist IL-10. Further studies are needed to correlate these genetic findings to direct cytokine measurements.

  12. Foliar photochemical processes and carbon metabolism under favourable and adverse winter conditions in a Mediterranean mixed forest, Catalonia (Spain)

    Science.gov (United States)

    Sperlich, D.; Chang, C. T.; Peñuelas, J.; Gracia, C.; Sabaté, S.

    2014-06-01

    Evergreen trees in the Mediterranean region must cope with a wide range of environmental stresses from summer drought to winter cold. The mildness of Mediterranean winters can periodically lead to favourable environmental conditions above the threshold for a positive carbon balance, benefitting evergreen woody species more than deciduous ones. The comparatively lower solar energy input in winter decreases the foliar light saturation point. This leads to a higher susceptibility to photoinhibitory stress especially when chilly (change persisted for several weeks after the cold period despite the recovery of the temperature to the conditions previous to the frost event. The responses of Vc, max and Jmax were highly species-specific, where Q. ilex exhibited the highest and P. halepensis the lowest reductions. In contrast, the optimal fluorometric quantum yield of photosystem II (Fv/Fm) was significantly lower in A. unedo after the cold period. The leaf position played an important role in Q. ilex showing a comparatively stronger winter effect on sunlit leaves. Our results generally agreed with the previous classifications of photoinhibition-avoiding (P. halepensis) and photoinhibition-tolerant (Q. ilex) species on the basis of their susceptibility to dynamic photoinhibition, whereas A. unedo was the least tolerant to photoinhibition, which was chronic in this species. Q. ilex and P. halepensis seem to follow contrasting photoprotective strategies which are, however, equally successful under the prevailing conditions exhibiting an adaptive advantage over A. unedo in our study site. These results show that our understanding of the dynamics of interspecific competition in Mediterranean ecosystems requires consideration of the physiological behaviour during winter which may have important implications for long-term carbon budgets and growth trends.

  13. Persuading, protesting and exchanging favours: strategies used by Indian sex workers to win local support for their HIV prevention programmes.

    Science.gov (United States)

    Cornish, Flora; Shukla, Anuprita; Banerji, Riddhi

    2010-01-01

    Given that the communities which are most vulnerable to HIV often have little control over their own lives and their health-related behaviour, HIV prevention policies increasingly recommend that HIV prevention projects work to build relationships with powerful external groups (i.e., build "bridging social capital"). To aid conceptualisation of how community organisations may build such social capital, this paper outlines a typology of strategies for influencing local stakeholders. We present a study of two successful Indian sex workers' organisations, VAMP and DMSC, focusing on how the organisations have influenced three groups of stakeholders, namely police, politicians and local social organisations. Interviews with project employees (45), with representatives of the three groups of stakeholders (12) and fieldwork diaries recording 6 months of observation in each site provide the data. Three approaches emerged. "Persuading" refers to the practice of holding information-giving meetings with stakeholders and requesting their support. It appears to build "weak social ties". "Protesting" entails a collective confrontation with stakeholders, and appears to be useful when the stakeholder has a public image to protect that would be tarnished by protest, and when the protestors can stake a legitimate claim that their rights are being denied. In "exchanging favours", the sex workers' organisations find creative ways to position themselves as offering valued resources to their stakeholders (such as useful information on criminal activities for the police, a stage and audience for politicians or a celebration for local social organisations) as incentives for their support. In conclusion, we discuss the strengths and weaknesses of each approach, the implications for social capital theorising and implications for community HIV prevention.

  14. Co-expression of HER3 and MUC1 is associated with a favourable prognosis in patients with bladder cancer

    DEFF Research Database (Denmark)

    Nielsen, Trine O; Borre, Michael; Nexo, Ebba;

    2015-01-01

    OBJECTIVES: To investigate the functional impact of the interaction of MUC1 with the epidermal growth factor receptors HER3 and HER4 in patients with bladder cancer. PATIENTS AND METHODS: Using reverse transcription quantitative polymerase chain reaction, we examined MUC1 expression in 82 bladder...... cancer biopsies previously examined for the expression of HER3. RESULTS: Patients expressing high MUC1 had a favourable survival when the expression of HER3 was also high compared with when the expression of HER3 was low (P = 0.004). When MUC1 expression was low, HER3 co-expression did not influence...... the prognostic value of MUC1 (P = 0.488). MUC1 expression had no correlation with survival, tumour stage or grade, or to the prognostic value of HER4. CONCLUSIONS: A high MUC1 expression was associated with a favourable prognosis in patients with bladder cancer when the expression of HER3 was also high...

  15. Testing the efficacy of downscaling in species distribution modelling: a comparison between MaxEnt and Favourability Function models

    OpenAIRE

    2016-01-01

    Statistical downscaling is used to improve the knowledge of spatial distributions from broad–scale to fine–scale maps with higher potential for conservation planning. We assessed the effectiveness of downscaling in two commonly used species distribution models: Maximum Entropy (MaxEnt) and the Favourability Function (FF). We used atlas data (10 x 10 km) of the fire salamander Salamandra salamandra distribution in southern Spain to derive models at a 1 x 1 km resolution. Downscaled models were...

  16. Non-fasting triglycerides predict incident acute myocardial infarction among those with favourable HDL-cholesterol: Cohort Norway.

    Science.gov (United States)

    Egeland, Grace M; Igland, Jannicke; Sulo, Gerhard; Nygård, Ottar; Ebbing, Marta; Tell, Grethe S

    2015-07-01

    to prospectively evaluate the risk of acute myocardial infarction (AMI) associated with non-fasting triglyceride levels. a health survey of 140,790 Norwegians free of known coronary heart disease at baseline (1994-2003) were followed through December 2009 via record linkages to the Cause of Death Registry and hospital discharge diagnoses in the CVDNOR project, and evaluated in Cox proportional hazards analyses. a total of 3219 (4.8%) men and 1434 (1.9%) women developed an AMI. Women had a steeper gradient risk with increasing triglyceride decile than men, where the highest (≥2.88 mmol/l) compared to the lowest decile (triglyceride interaction term was observed. HRs increased with increasing triglyceride quartile in participants with a favourable HDL-C after multivariable adjustment (p for trend triglycerides did not significantly predict AMI among those with low HDL-C. For those with favourable HDL-C, net reclassification index identified a 10% and 14% improvement in classification for men and women, respectively. non-fasting triglyceride levels among individuals with favourable HDL-C may help identify a subset of individuals at risk for CHD. Further research is warranted in evaluating non-fasting triglycerides in CHD prediction. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  17. Foliar photochemical processes and carbon metabolism under favourable and adverse winter conditions in a Mediterranean mixed forest, Catalonia (Spain

    Directory of Open Access Journals (Sweden)

    D. Sperlich

    2014-06-01

    Full Text Available Evergreen trees in the Mediterranean region must cope with a wide range of environmental stresses from summer drought to winter cold. The mildness of Mediterranean winters can periodically lead to favourable environmental conditions above the threshold for a positive carbon balance, benefitting evergreen woody species more than deciduous ones. The comparatively lower solar energy input in winter decreases the foliar light saturation point. This leads to a higher susceptibility to photoinhibitory stress especially when chilly (Quercus ilex L., Pinus halepensis Mill., and Arbutus unedo L. during a period of mild winter conditions and their responses to a sudden cold period. The state of the photosynthetic machinery in both periods was thus tested by estimating the foliar photosynthetic potential with CO2 response curves in parallel with chlorophyll fluorescence measurements. The studied evergreen tree species benefited strongly from mild winter conditions by exhibiting extraordinarily high photosynthetic potentials similar to those under spring conditions. A sudden period of frost, however, negatively affected the photosynthetic apparatus, leading to significant decreases in key physiological parameters such as the maximum carboxylation velocity (Vc, max, the maximum photosynthetic electron transport rate (Jmax, and the optimal fluorometric quantum yield of photosystem II (Fv/Fm. This change persisted for several weeks after the cold period despite the recovery of the temperature to the conditions previous to the frost event. The responses of Vc, max and Jmax were highly species-specific, where Q. ilex exhibited the highest and P. halepensis the lowest reductions. In contrast, the optimal fluorometric quantum yield of photosystem II (Fv/Fm was significantly lower in A. unedo after the cold period. The leaf position played an important role in Q. ilex showing a comparatively stronger winter effect on sunlit leaves. Our results generally agreed with

  18. Foliar photochemical processes and carbon metabolism under favourable and adverse winter conditions in a Mediterranean mixed forest, Catalonia (Spain)

    Science.gov (United States)

    Sperlich, D.; Chang, C. T.; Peñuelas, J.; Gracia, C.; Sabaté, S.

    2014-10-01

    Evergreen trees in the Mediterranean region must cope with a wide range of environmental stresses from summer drought to winter cold. The mildness of Mediterranean winters can periodically lead to favourable environmental conditions above the threshold for a positive carbon balance, benefitting evergreen woody species more than deciduous ones. The comparatively lower solar energy input in winter decreases the foliar light saturation point. This leads to a higher susceptibility to photoinhibitory stress especially when chilly (compensates for the lower carbon uptake during spring and summer in comparison to deciduous species. We investigated the ecophysiological behaviour of three co-occurring mature evergreen tree species (Quercus ilex L., Pinus halepensis Mill., and Arbutus unedo L.). Therefore, we collected twigs from the field during a period of mild winter conditions and after a sudden cold period. After both periods, the state of the photosynthetic machinery was tested in the laboratory by estimating the foliar photosynthetic potential with CO2 response curves in parallel with chlorophyll fluorescence measurements. The studied evergreen tree species benefited strongly from mild winter conditions by exhibiting extraordinarily high photosynthetic potentials. A sudden period of frost, however, negatively affected the photosynthetic apparatus, leading to significant decreases in key physiological parameters such as the maximum carboxylation velocity (Vc, max), the maximum photosynthetic electron transport rate (Jmax), and the optimal fluorometric quantum yield of photosystem II (Fv/Fm). The responses of Vc, max and Jmax were highly species specific, with Q. ilex exhibiting the highest and P. halepensis the lowest reductions. In contrast, the optimal fluorometric quantum yield of photosystem II (Fv/Fm) was significantly lower in A. unedo after the cold period. The leaf position played an important role in Q. ilex showing a stronger winter effect on sunlit leaves in

  19. Farming systems in two less favoured areas in portugal: their development from 1989 to 2009 and the implications for sustainable land management

    NARCIS (Netherlands)

    Jones, N.M.; Graaff, de J.; Duarte, F.; Rodrigo, I.; Poortinga, A.

    2014-01-01

    Since the late 1980s, sustainable land management is one of the objectives of the European Commission in Less Favoured Areas. In this paper, we investigate the economic and environmental sustainability of farming systems in two less favoured areas in Centro and Alentejo areas of Portugal. The specif

  20. Coronary computed tomography angiography without significant stenosis predicts favourable three-year prognosis

    DEFF Research Database (Denmark)

    Kristiansen, Jeppe Maagaard; Zaremba, Tomas; Johansen, Martin Berg

    2014-01-01

    INTRODUCTION: The objective of this study was to evaluate the incidence of death, cardiovascular events and the use of later non-scheduled imaging for coronary artery disease (CAD) in patients suspected for CAD and discharged without a need for further examination or treatment from an outpatient...... clinic following coronary computed tomography angiography (CCTA). MATERIAL AND METHODS: This was a retrospective cohort study among patients discharged from an outpatient clinic after CCTA at our institution during 2009 and 2010. Follow-up was performed using nationwide Danish registers. RESULTS: A total...... of acute myocardial infarction and no cases of death related to cardiovascular disease. A total of 5.0% of the patients later underwent non-scheduled imaging, predominantly invasive coronary angiography. No patients had revascularisation performed during the study period. CONCLUSION: Patients...

  1. Dog-associated husbandry practices favouring the spread of zoonotic pathogens with reference to helminth and arthropod parasites in Yaounde, Cameroon

    Directory of Open Access Journals (Sweden)

    N jong

    2012-11-01

    Full Text Available Dogs are the most common animal species kept around households and are also known to be source of diseases of importance to human health. The aim of this study was to determine some characteristics of dog population and husbandry practices that favour the spread of zoonotic parasites in Yaounde, Cameroon. Three hundred and twenty-two households owning at least one dog were recruited into the study. Information on dog and household characteristics as well as potential risk factors for the transmission of dog-related zoonotic parasites was collected using self-administered questionnaires. Over three-quarters of the households (76% owned one dog each while 62% (200/322 kept dogs strictly for security reasons. Eighty four per cent (270/322 of the dogs owned were of local breed type and dominated by male dogs (64%. Twenty five per cent (80/320 of households left their dogs permanently free while 84% (240/320 declared negligence in disposing dog’s faeces. Dogs in 35.5% (114/320 of the households rarely or have never been consulted by a veterinarian. Although 242 (75% respondents were aware of zoonotic diseases, only 51 (21% of these knew parasites from dogs may infect human beings. The provision of a defecation site for dogs and access to living quarters were associated with household head’s level of education and care taker category, respectively. The current dog husbandry practices in Yaounde are likely to favour the spread of dog-related zoonotic diseases. Further investigations to determine the prevalence of zoonotic parasites, educational intervention as well as routine veterinary care are necessary to reduce the risk exposures to zoonotic parasites from dogs.  

  2. Coronary computed tomography angiography without significant stenosis predicts favourable three-year prognosis

    DEFF Research Database (Denmark)

    Kristiansen, Jeppe Maagaard; Zaremba, Tomas; Johansen, Martin Berg;

    2014-01-01

    INTRODUCTION: The objective of this study was to evaluate the incidence of death, cardiovascular events and the use of later non-scheduled imaging for coronary artery disease (CAD) in patients suspected for CAD and discharged without a need for further examination or treatment from an outpatient...... of acute myocardial infarction and no cases of death related to cardiovascular disease. A total of 5.0% of the patients later underwent non-scheduled imaging, predominantly invasive coronary angiography. No patients had revascularisation performed during the study period. CONCLUSION: Patients...

  3. Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels

    NARCIS (Netherlands)

    Kubben, F.J.G.M.; Sier, C.F.M.; Schram, M.; Witte, T.A.M.C.; Veenendaal, R.A.; Duijn, W. van; Verheijen, J.H.; Hanemaaijer, R.; Lamers, C.B.H.W.; Verspaget, H.W.

    2007-01-01

    Background: Helicobacter pylori gastritis is recognized as an important pathogenetic factor in peptic ulcer disease and gastric carcinogenesis, and is accompanied by strongly enhanced gastric mucosal matrix metalloproteinase-9 (MMP-9) levels. Aim: This study was performed to investigate whether H.

  4. Eradication of Helicobacter pylori infection favourably affects altered gastric mucosal MMP-9 levels

    NARCIS (Netherlands)

    Kubben, F.J.G.M.; Sier, C.F.M.; Schram, M.; Witte, T.A.M.C.; Veenendaal, R.A.; Duijn, W. van; Verheijen, J.H.; Hanemaaijer, R.; Lamers, C.B.H.W.; Verspaget, H.W.

    2007-01-01

    Background: Helicobacter pylori gastritis is recognized as an important pathogenetic factor in peptic ulcer disease and gastric carcinogenesis, and is accompanied by strongly enhanced gastric mucosal matrix metalloproteinase-9 (MMP-9) levels. Aim: This study was performed to investigate whether H. p

  5. Sexual antagonism and meiotic drive cause stable linkage disequilibrium and favour reduced recombination on the X chromosome.

    Science.gov (United States)

    Rydzewski, W T; Carioscia, S A; Liévano, G; Lynch, V D; Patten, M M

    2016-06-01

    Sexual antagonism and meiotic drive are sex-specific evolutionary forces with the potential to shape genomic architecture. Previous theory has found that pairing two sexually antagonistic loci or combining sexual antagonism with meiotic drive at linked autosomal loci augments genetic variation, produces stable linkage disequilibrium (LD) and favours reduced recombination. However, the influence of these two forces has not been examined on the X chromosome, which is thought to be enriched for sexual antagonism and meiotic drive. We investigate the evolution of the X chromosome under both sexual antagonism and meiotic drive with two models: in one, both loci experience sexual antagonism; in the other, we pair a meiotic drive locus with a sexually antagonistic locus. We find that LD arises between the two loci in both models, even when the two loci freely recombine in females and that driving haplotypes will be enriched for male-beneficial alleles, further skewing sex ratios in these populations. We introduce a new measure of LD, Dz', which accounts for population allele frequencies and is appropriate for instances where these are sex specific. Both models demonstrate that natural selection favours modifiers that reduce the recombination rate. These results inform observed patterns of congealment found on driving X chromosomes and have implications for patterns of natural variation and the evolution of recombination rates on the X chromosome.

  6. Intermittent preventive therapy for malaria: arguments in favour of artesunate and sulphamethoxypyrazine - pyrimethamine combination

    Directory of Open Access Journals (Sweden)

    Jansen Frans

    2011-03-01

    Full Text Available Abstract Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP for the intermittent preventive treatment of malaria in young children (IPTi. Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine, it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours. It is recommended that this combination should be tested in future field studies of IPTi.

  7. Goats favour personal over social information in an experimental foraging task

    Directory of Open Access Journals (Sweden)

    Luigi Baciadonna

    2013-09-01

    Full Text Available Animals can use their environments more efficiently by selecting particular sources of information (personal or social, according to specific situations. Group-living animals may benefit from gaining information based on the behaviour of other individuals. Indeed, social information is assumed to be faster and less costly to use than personal information, thus increasing foraging efficiency. However, when food sources change seasonally or are randomly distributed, individual information may become more reliable than social information. The aim of this study was to test the use of conflicting personal versus social information in goats (Capra hircus, in a foraging task. We found that goats relied more on personal than social information, when both types of information were available and in conflict. No effect of social rank was found on the occasions when goats followed other demonstrator goats. Goats are selective browsers/grazers and therefore relying on personal rather than social information could be the most efficient way to find patchily distributed resources in highly variable environments. Studies testing specific assumptions regarding the use of different sources of information can extend our understanding of decision making, including observed patterns of social learning.

  8. Goats favour personal over social information in an experimental foraging task.

    Science.gov (United States)

    Baciadonna, Luigi; McElligott, Alan G; Briefer, Elodie F

    2013-01-01

    Animals can use their environments more efficiently by selecting particular sources of information (personal or social), according to specific situations. Group-living animals may benefit from gaining information based on the behaviour of other individuals. Indeed, social information is assumed to be faster and less costly to use than personal information, thus increasing foraging efficiency. However, when food sources change seasonally or are randomly distributed, individual information may become more reliable than social information. The aim of this study was to test the use of conflicting personal versus social information in goats (Capra hircus), in a foraging task. We found that goats relied more on personal than social information, when both types of information were available and in conflict. No effect of social rank was found on the occasions when goats followed other demonstrator goats. Goats are selective browsers/grazers and therefore relying on personal rather than social information could be the most efficient way to find patchily distributed resources in highly variable environments. Studies testing specific assumptions regarding the use of different sources of information can extend our understanding of decision making, including observed patterns of social learning.

  9. Biodeterioration of Pompeian mural paintings: fungal colonization favoured by the presence of volcanic material residues.

    Science.gov (United States)

    Veneranda, Marco; Prieto-Taboada, Nagore; de Vallejuelo, Silvia Fdez-Ortiz; Maguregui, Maite; Morillas, Hector; Marcaida, Iker; Castro, Kepa; Madariaga, Juan Manuel; Osanna, Massimo

    2017-07-05

    This work was focused on the study of the biodegradation processes jeopardizing a mural painting conserved in the basement of Ariadne House (archaeological site of Pompeii, Italy). The fresco stood out for its peculiar state of preservation: the upper part, recovered in 1988, was just barely colonized by microorganisms. On the contrary, the lower part (excavated in 2005) was almost completely covered by extensive biological patinas. The genomic characterization carried out by polymerase chain reaction (PCR) highlighted the presence of seven different fungi strains on the mural surface. Beside, in situ and laboratory analyses were performed with the purpose of identifying the causes of the heterogeneous spatial distribution of the biopatinas. The in situ Raman spectroscopy and energy dispersive X-ray fluorescence (ED-XRF) spectroscopy measurements excluded any link between the heterogeneous colonization and the original materials present in the wall. On the other side, X-ray diffraction (XRD) and scanning electron microscopy (SEM) on microsamples proved the presence of a thin volcanic material layer overlying the lower part of the fresco. Considering that most of the biofilms of the studied mural painting only growth over these residues, it was confirmed the role of volcanic material as a suitable support for biological colonization. Thanks to the obtained results, this research helped to understand more in depth an important degradation pathway threatening the artworks from one of the most important archaeological sites in the world.

  10. The natural antioxidants, pomegranate extract and soy isoflavones, favourably modulate canine endothelial cell function.

    Science.gov (United States)

    Baumgartner-Parzer, Sabina M; Waldenberger, Ferdinand Rudolf; Freudenthaler, Angelika; Ginouvès-Guerdoux, Amandine; McGahie, David; Gatto, Hugues

    2012-01-01

    Cardiovascular disease, preceded by vascular endothelial dysfunction, is a prominent cause of death in dogs. L-carnitine and taurine, well known for their antioxidative capacity, beneficially affect cardiovascular disease as well as certain dog cardiomyopathies. It is well established that vascular endothelial dysfunction precedes cardiovascular disease and that "vasoprotective factors" (NO and antioxidants) prevent apoptosis, whereas "risk factors" such as oxidized LDL, hyperglycemia, and free fatty acids trigger it in cultured human vascular endothelial cells. Whereas human vascular cell in vitro models are widely established and used for the characterisation of potential vasoprotective substances, such models are not available for canine endothelial cells. In the present study we therefore developed an in vitro model, which allows the testing of the effects of different substances on proliferation and apoptosis in canine aortic endothelial cells. This model was used to test L-carnitine, taurine, pomegranate extract, and Soy Isoflavones in comparison to reference substances (glutathione and pioglitazone) previously shown to modulate human endothelial cell function. L-carnitine and taurine neither exhibited antiproliferative nor antiapoptotic activities in the context of this study. However extracts from pomegranate and soy isoflavones dramatically reduced proliferation and apoptosis in a dose dependent fashion, being in line with a vasoprotective activity in dogs.

  11. Clinical heterogeneity among people with high functioning autism spectrum conditions: evidence favouring a continuous severity gradient

    Directory of Open Access Journals (Sweden)

    Woodbury-Smith Marc

    2008-02-01

    Full Text Available Abstract Background Autism Spectrum Conditions (ASCs are characterized by a high degree of clinical heterogeneity, but the extent to which this variation represents a severity gradient versus discrete phenotypes is unclear. This issue has complicated genetic studies seeking to investigate the genetic basis of the high hereditability observed clinically in those with an ASC. The aim of this study was to examine the possible clustering of symptoms associated with ASCs to determine whether the observed distribution of symptom type and severity supported either a severity or a symptom subgroup model to account for the phenotypic variation observed within the ASCs. Methods We investigated the responses of a group of adults with higher functioning ASCs on the fifty clinical features examined in the Autism Spectrum Quotient, a screening questionnaire used in the diagnosis of higher functioning ASCs. In contrast to previous studies we have used this instrument with no a priori assumptions about any underlying factor structure of constituent items. The responses obtained were analyzed using complete linkage hierarchical cluster analysis. For the members of each cluster identified the mean score on each Autism Spectrum Quotient question was calculated. Results Autism Spectrum Quotient responses from a total of 333 individuals between the ages of 16.6 and 78.0 years were entered into the hierarchical cluster analysis. The four cluster solution was the one that generated the largest number of clusters that did not also include very small cluster sizes, defined as a membership comprising 10 individuals or fewer. Examination of these clusters demonstrated that they varied in total Autism Spectrum Quotient but that the profiles across the symptoms comprising the Autism Spectrum Quotient did not differ independently of this severity factor. Conclusion These results are consistent with a unitary spectrum model, suggesting that the clinical heterogeneity observed

  12. Aspergillus spp. invasive external otitis: favourable outcome with a medical approach.

    Science.gov (United States)

    Marchionni, E; Parize, P; Lefevre, A; Vironneau, P; Bougnoux, M E; Poiree, S; Coignard-Biehler, H; DeWolf, S E; Amazzough, K; Barchiesi, F; Jullien, V; Alanio, A; Garcia-Hermoso, D; Wassef, M; Kania, R; Lortholary, O; Lanternier, F

    2016-05-01

    Aspergillus spp. invasive external otitis (IEO) is a rare infection. We performed a seven-year, single-centre retrospective study from 2007 to 2014 including all patients with proven Aspergillus spp. IEO. Twelve patients were identified. All patients had a poorly controlled diabetes mellitus and one underwent solid organ transplant. The most frequently isolated species was Aspergillus flavus (n = 10) and voriconazole was the first-line therapy in all cases, with a median length of treatment of 338.5 days (158-804 days). None of the patients underwent extensive surgery. The clinical outcome was excellent. However, otological sequelae were reported, including hearing impairment (n = 7) and facial palsy (n = 3).

  13. Evidence for maternally inherited factors favouring male homosexuality and promoting female fecundity.

    Science.gov (United States)

    Camperio-Ciani, Andrea; Corna, Francesca; Capiluppi, Claudio

    2004-11-07

    The Darwinian paradox of male homosexuality in humans is examined, i.e. if male homosexuality has a genetic component and homosexuals reproduce less than heterosexuals, then why is this trait maintained in the population? In a sample of 98 homosexual and 100 heterosexual men and their relatives (a total of over 4600 individuals), we found that female maternal relatives of homosexuals have higher fecundity than female maternal relatives of heterosexuals and that this difference is not found in female paternal relatives. The study confirms previous reports, in particular that homosexuals have more maternal than paternal male homosexual relatives, that homosexual males are more often later-born than first-born and that they have more older brothers than older sisters. We discuss the findings and their implications for current research on male homosexuality.

  14. Development of a methodology for dissemination and formation favourable of using nuclear energy

    Energy Technology Data Exchange (ETDEWEB)

    Lobo, Belinda Maria; Aquino, Afonso Rodrigues de, E-mail: belindalobo@usp.br, E-mail: araquino@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2015-07-01

    Space Nuclear Technology (ENT), located in the IPEN is the basis for the study of a reporting methodology of Nuclear Energy Technology, for the public get some physical-chemical knowledge, benefits of using radioactivity and the activities carried out by the Institute Energy and Nuclear Research - National Commission of Nuclear Energy (IPEN / CNEN), for increased acceptance of its use. This article reports the survey in two schools, with groups of teachers from different areas of elementary and secondary education of the Sao Paulo state. The strategies used to establish communication by means of an environment of trust are: a questionnaire at the beginning and end of the presentation, one sensationalised reporting, Cesium -137 -Linha Direta, aired by Rede Globo TV, in 2007, theoretical foundation of physics and chemistry, picturesque figures and photos as the Nuclear Reactor IEA-R1. The contributions of this research will improve the methodology for future presentations. (author)

  15. Intramedullary tumours in patients with neurofibromatosis type 2: MRI features associated with a favourable prognosis

    Energy Technology Data Exchange (ETDEWEB)

    Rennie, A.T.M. [Department of Neuroradiology, West Wing, John Radcliffe Hospital, Headington, Oxford (United Kingdom)], E-mail: atmrennie@hotmail.com; Side, L. [Department of Clinical Genetics, Churchill Hospital, Headington, Oxford (United Kingdom); Kerr, R.S.C. [Department of Neurosurgery, West Wing, John Radcliffe Hospital, Headington, Oxford (United Kingdom); Anslow, P.; Pretorius, P. [Department of Neuroradiology, West Wing, John Radcliffe Hospital, Headington, Oxford (United Kingdom)

    2008-02-15

    Aim: To assess the magnetic resonance imaging (MRI) features and natural history of intramedullary tumours in patients with neurofibromatosis type 2 (NF2). Materials and methods: Eleven NF2 patients with intramedullary spinal cord tumours were identified from the database of the multidisciplinary NF2 clinic. All the imaging studies of these patients were individually reviewed by two neuroradiologists to evaluate the size, number, location, imaging characteristics, and interval growth of the intramedullary tumours. Results: Two of the 11 patients had lesions that required surgery. Both these lesions were in the cervical region, and extended over three and five segments respectively. Nine patients with a mean imaging follow-up period of 77 months had lesions that remained stable, apart from the development of small peritumoral cysts in three. The lesions were well circumscribed, often multiple, usually less than 1 cm in diameter, and were most frequently found in the cervical cord. Conclusion: The majority of intramedullary tumours in NF2 patients are very slow growing and share certain MRI features that differ from those of progressive or symptomatic lesions.

  16. Pyridoxine-dependent epilepsy due to antiquitin deficiency: achieving a favourable outcome.

    Science.gov (United States)

    Oliveira, Renata; Pereira, Cristina; Rodrigues, Fidjy; Alfaite, Claudia; Garcia, Paula; Robalo, Conceição; Fineza, Isabel; Gonçalves, Olavo; Struys, Eduard; Salomons, Gajja; Jakobs, Cornelis; Diogo, Luísa

    2013-12-01

    We report 4 pyridoxine-dependent epilepsy patients in which good outcome was determined in three. The 4 patients were male and aged from 7 to 24 years old (from three unrelated Caucasian families). A clinical diagnosis of neonatal pyridoxine-dependent epilepsy was confirmed by biochemical and genetic studies. Clinical evaluation was performed and medical records were reviewed for therapy implementation and management, neurodevelopment outcome, magnetic resonance imaging, and electroencephalography. All were taking pyridoxine treatment and were seizure-free. Elevated urinary alpha-aminoadipic semialdehyde excretion was found in all patients. Antiquitin gene analysis identified a large homozygous deletion in one patient and two heterozygous mutations in the others. Treatment with pyridoxine should be attempted for all cases of infantile and childhood refractory epilepsy, as has been the case over the last 20 years. Currently, urinary alpha-aminoadipic semialdehyde is a reliable biomarker of pyridoxine-dependent epilepsy, even under pyridoxine treatment. Detection of mutations in the antiquitin gene, encoding alpha-aminoadipic semialdehyde dehydrogenase, establishes the diagnosis and allows for adequate genetic counselling.

  17. Foreign direct investment in the health care sector and most-favoured locations in developing countries.

    Science.gov (United States)

    Outreville, J François

    2007-12-01

    Given the growing importance of the health care sector and the significant development of trade in health services, foreign direct investment (FDI) in this sector has gathered momentum with the General Agreement on Trade in Services. Despite extensive case based research and publications in recent years on health care markets and the rise of private sectors, it is surprisingly difficult to find evidence on the relative importance of the largest multinational corporations (MNCs) operating in the health care sector. The objective of the paper is to identify some of the determinants of foreign investment of the largest MNCs operating in this industry. The list of the largest MNCs has been compiled using company websites and data is available for 41 developing economies for which at least two MNCs have an office (branch and/or affiliate). The results of this study have some important implications. They indicate that location-specific advantages of host countries, including good governance, do provide an explication of the internationalization of firms in some developing countries rather than others.

  18. To evaluate stereoacuity in patients with acquired esotropia and to determine factors associated with favourable outcomes

    Directory of Open Access Journals (Sweden)

    Monisha E Nongpiur

    2014-01-01

    Full Text Available Aim: To evaluate stereoacuity in patients with acquired esotropia and determine the factors associated with favorable outcomes. Materials and Methods: A total of 68 subjects aged 6 years and above were included in the study. Thorough clinical evaluation including binocular status examination using the Bagolini-striated glass test, The Netherland Organization (TNO, and Randot stereo test were done. The subjects were divided into two groups 1 and 2, based on the amount of deviation. Statistical analysis of the result was performed. Result: The duration of misalignment in the group with deviation less than or equal to 8 prism diopters (PD was 1.49 ± 0.86 years, whereas in the group with deviation more than or equal to 10 PD was 4.64 ± 2.99 years (P = 0.000. Among the subjects in group 1, 89.5% achieved fusion and 52.6% had stereoacuity on both TNO and Randot, whereas in group 2 40% achieved fusion and 3.3% stereopsis on both TNO and Randot (one case with only coarse stereopsis. A subanalysis within group 1 revealed a statistically significant difference for the duration of misalignment (P = 0.02, but a marginal difference for the amount of deviation (P = 0.3. Conclusion: A horizontal deviation up to 8 PD was compatible with stereopsis. Also, the duration of constant misalignment affects the attainment of stereopsis despite successful realignment.

  19. Hidden epistastic interactions can favour the evolution of sex and recombination.

    Directory of Open Access Journals (Sweden)

    Joel R Peck

    Full Text Available Deleterious mutations can have a strong influence on the outcome of evolution. The nature of this influence depends on how mutations combine together to affect fitness. "Negative epistasis" occurs when a new deleterious mutation causes the greatest loss in fitness in a genome that already contains many deleterious mutations. Negative epistasis is a key ingredient for some of the leading hypotheses regarding the evolution of recombination, the evolution of sex, and a variety of other phenomena. In general, laboratory studies have not supported the idea that negative epistasis is ubiquitous, and this has led to doubts about its importance in biological evolution. Here, we show that these experimental results may be misleading, because negative epistasis can produce evolutionary advantages for sex and recombination while simultaneously being almost impossible to detect using current experimental methods. Under asexual reproduction, such hidden epistasis influences evolutionary outcomes only if the fittest individuals are present in substantial numbers, while also forming a very small proportion of the population as a whole. This implies that our results for asexuals will apply only for very large populations, and also limits the extent of the fitness benefits that hidden epistasis can provide. Despite these caveats, our results show that the fitness consequences of sex and recombination cannot always be inferred from observable epistasis alone.

  20. Fortune favours the brave: Movement responses shape demographic dynamics in strongly competing populations.

    Science.gov (United States)

    Potts, Jonathan R; Petrovskii, Sergei V

    2017-05-07

    Animal movement is a key mechanism for shaping population dynamics. The effect of interactions between competing animals on a population's survival has been studied for many decades. However, interactions also affect an animal's subsequent movement decisions. Despite this, the indirect effect of these decisions on animal survival is much less well-understood. Here, we incorporate movement responses to foreign animals into a model of two competing populations, where inter-specific competition is greater than intra-specific competition. When movement is diffusive, the travelling wave moves from the stronger population to the weaker. However, by incorporating behaviourally induced directed movement towards the stronger population, the weaker one can slow the travelling wave down, even reversing its direction. Hence movement responses can switch the predictions of traditional mechanistic models. Furthermore, when environmental heterogeneity is combined with aggressive movement strategies, it is possible for spatially segregated co-existence to emerge. In this situation, the spatial patterns of the competing populations have the unusual feature that they are slightly out-of-phase with the environmental patterns. Finally, incorporating dynamic movement responses can also enable stable co-existence in a homogeneous environment, giving a new mechanism for spatially segregated co-existence. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Patulin is a cultivar-dependent aggressiveness factor favouring the colonization of apples by Penicillium expansum.

    Science.gov (United States)

    Snini, Selma P; Tannous, Joanna; Heuillard, Pauline; Bailly, Sylviane; Lippi, Yannick; Zehraoui, Enric; Barreau, Christian; Oswald, Isabelle P; Puel, Olivier

    2016-08-01

    The blue mould decay of apples is caused by Penicillium expansum and is associated with contamination by patulin, a worldwide regulated mycotoxin. Recently, a cluster of 15 genes (patA-patO) involved in patulin biosynthesis was identified in P. expansum. blast analysis revealed that patL encodes a Cys6 zinc finger regulatory factor. The deletion of patL caused a drastic decrease in the expression of all pat genes, leading to an absence of patulin production. Pathogenicity studies performed on 13 apple varieties indicated that the PeΔpatL strain could still infect apples, but the intensity of symptoms was weaker compared with the wild-type strain. A lower growth rate was observed in the PeΔpatL strain when this strain was grown on nine of the 13 apple varieties tested. In the complemented PeΔpatL:patL strain, the ability to grow normally in apple and the production of patulin were restored. Our results clearly demonstrate that patulin is not indispensable in the initiation of the disease, but acts as a cultivar-dependent aggressiveness factor for P. expansum. This conclusion was strengthened by the fact that the addition of patulin to apple infected by the PeΔpatL mutant restored the normal fungal colonization in apple.

  2. Diverse seed banks favour adaptation of microalgal populations to future climate conditions.

    Science.gov (United States)

    Kremp, Anke; Oja, Johanna; LeTortorec, Anniina H; Hakanen, Päivi; Tahvanainen, Pia; Tuimala, Jarno; Suikkanen, Sanna

    2016-02-01

    Selection of suitable genotypes from diverse seed banks may help phytoplankton populations to cope with environmental changes. This study examines whether the high genotypic diversity found in the Baltic cyst pool of the toxic dinoflagellate Alexandrium ostenfeldii is coupled to phenotypic variability that could aid short-term adaptation. Growth rates, cellular toxicities and bioluminescence of 34 genetically different clones isolated from cyst beds of four Baltic bloom sites were determined in batch culture experiments along temperature and salinity gradients covering present and future conditions in the Baltic Sea. For all parameters a significant effect of genotype on the response to temperature and salinity changes was identified. General or site-specific effects of the two factors remained minor. Clones thriving at future conditions were different from the best performing at present conditions, suggesting that genotypic shifts may be expected in the future. Increased proportions of highly potent saxitoxin were observed as a plastic response to temperature increase, indicating a potential for higher toxicity of future blooms. The observed standing variation in Baltic seed banks of A. ostenfeldii suggests that the population is likely to persist under environmental change.

  3. Aid and the growth of income in aid-favoured developing countries: policy issues.

    Science.gov (United States)

    Brewster, H; Yeboah, D

    1994-04-01

    This paper opens by expressing disappointment in the disparities between published estimations of the effectiveness of foreign aid to developing countries and effectiveness data which arise from the application of complex econometric methods. The new dilemmas for aid policy include the fact that aid increasingly devoted to human development at the expense of productive activity is unlikely to create the material development which will allow maintenance of human development targets. The second part of the paper presents comparative statistics on gross national product, official development assistance, and savings growth which paint a disturbing picture because the growth of domestic savings has been negative in the period 1967-87 in nine of the 11 less developed countries with data available. Section 3 covers the shortcomings of econometric experiments which neither confirm nor deny the findings of other studies on the effectiveness of aid. The fourth section describes constraints to the growth of income imposed by the foreign exchange, the rate of return on investment, and the growth of labor productivity and presents statistical evidence supporting aid policy which would 1) take advantage of opportunities to rehabilitate output growth in traditional industries without the addition of a great deal of capital, 2) direct attention to increasing the absolute gross national product (GNP) to raise the growth of per capital income, and 3) strategically reorient the structure of aid to increase the absolute GNP faster to accelerate reversal of the negative savings pattern and speed the reduction of fertility. Section 5 considers suggested shifts in aid policy orientation dealing with 1) population growth, income level, and food security; 2) reconstruction and structural adjustment; 3) rationalizing aid for social, institutional, and human development and technical assistance. The concluding section notes that the suggested strategic reorientation of the structure of aid

  4. From favours to entitlements: community voice and action and health service quality in Zambia

    Science.gov (United States)

    Topp, Stephanie M.; Ngulube, Moses

    2017-01-01

    Abstract Social accountability is increasingly invoked as a way of improving health services. This article presents a theory-driven qualitative study of the context, mechanisms and outcomes of a social accountability program, Citizen Voice and Action (CVA), implemented by World Vision (WV) in Zambia. Primary data were collected between November 2013 and January 2014. It included in-depth interviews and focus group discussions with program stakeholders. Secondary data were used iteratively—to inform the process for primary data collection, to guide primary data analysis and to contextualize findings from the primary data. CVA positively impacted the state, society, state–society relations and development coordination at the local level. Specifically, sustained improvements in some aspects of health system responsiveness, empowered citizens, the improved provision of public goods (health services) and increased consensus on development issues appeared to flow from CVA. The central challenge described by interviewees and FGD participants was the inability of CVA to address problems that required central level input. The mechanisms that generated these outcomes included productive state–society communication, enhanced trust, and state–society co-production of priorities and the provision of services. These mechanisms were activated in the context of existing structures for state–society interaction, willing political leaders, buy-in by traditional leaders, and WV’s strong reputation and access to resources. Prospective observational research in multiple contexts would shed more light on the context, mechanisms and outcomes of CVA programs. In addition to findings that are intuitive and well supported in the literature we identified new areas that are promising areas for future research. These include (1) the context of organizational reputation by the organization(s) spearheading social accountability efforts; (2) the potential relationship between social

  5. Adiponectin expression in patients with inflammatory cardiomyopathy indicates favourable outcome and inflammation control.

    Science.gov (United States)

    Bobbert, Peter; Scheibenbogen, Carmen; Jenke, Alexander; Kania, Gabriele; Wilk, Sabrina; Krohn, Stefanie; Stehr, Jenny; Kuehl, Uwe; Rauch, Ursula; Eriksson, Urs; Schultheiss, Heinz Peter; Poller, Wolfgang; Skurk, Carsten

    2011-05-01

    Circulating adiponectin (APN) is an immunomodulatory, pro-angiogenic, and anti-apoptotic adipocytokine protecting against acute viral heart disease and preventing pathological remodelling after cardiac injury. The purpose of this study was to describe the regulation and effects of APN in patients with inflammatory cardiomyopathy (DCMi). Adiponectin expression and outcome were assessed in 173 patients with DCMi, 30 patients with non-inflammatory DCM, and 30 controls. Mechanistic background of these findings was addressed in murine experimental autoimmune myocarditis (EAM), a model of human DCMi, and further elucidated in vitro. Adiponectin plasma concentrations were significantly higher in DCMi compared with DCM or controls, i.e. 6.8 ± 3.9 µg/mL vs. 5.4 ± 3.6 vs. 4.76 ± 2.5 µg/mL (P< 0.05, respectively) and correlated significantly with cardiac mononuclear infiltrates (CD3+: r(2)= 0.025, P= 0.038; CD45R0+: r(2)= 0.058, P= 0.018). At follow-up, DCMi patients with high APN levels showed significantly increased left ventricular ejection fraction improvement, decreased left ventricular end-diastolic diameter, and reduced cardiac inflammatory infiltrates compared with patients with low APN levels. A multivariate linear regression analysis implicated APN as an independent prognostic factor for inhibition of cardiac inflammation. In accordance with these findings in human DCMi, EAM mice exhibited elevated plasma APN. Adiponectin gene transfer led to significant downregulation of key inflammatory mediators promoting disease. Mechanistically, APN acted as a negative regulator of T cells by reducing antigen specific expansion (P< 0.01) and suppressed TNFα-mediated NFκB activation (P< 0.01) as well as release of reactive oxygen species in cardiomyocytes. Our results implicate that APN acts as endogenously upregulated anti-inflammatory cytokine confining cardiac inflammation and progression in DCMi.

  6. The acceptability of arguments in favour of and against the Iraq War

    Directory of Open Access Journals (Sweden)

    Juan LaLlave

    2005-10-01

    Full Text Available This paper reports on research based on an experimental questionnaire designed using the logic and the basic structure of the Moral Judgment Test (MJT by Lind (1982. The study aims at understanding how respondents' acceptance of political arguments may have contributed to the lack of international support for the Iraq war and/or to the failure to prevent a preemptive attack. It examines factors, which respondents may have relied on in their acceptance of the arguments. The instrument consisted of three components: (1 A brief vignette on the declared beginning (March 19, 2003 and ending (May 1, 2003 of major operations in Iraq. (2 Respondents' own agreement with the need for the war. (3 Twelve arguments from political speeches: Six arguments by Bush and Blair "in favor of" (pro, and six arguments by Chirac and Schroeder "against" (con the need for the Iraq war. We scored each argument using Kohlberg's (1984 stage theory and Commons' Hierarchical Complexity Scoring System (HCSS (Commons et al., 2004, which identifies hierarchical features in the structure. Using Kempf's (2003 Cognitive Escalation and De-Escalation Model (CEDM we scored each argument sentence for details. Our sample consists of (N = 397 respondents of which were 56.4% women, 24.2% men, and 19.4% did not specify. The largest groups consisted of 71% Germans, 37.2% Catholics, 74.3% between the ages of 18-20 with high school education. Another group consisted of 8.6% Americans with a broader spectrum in age and higher educational level. Using 7 point Likert scales, respondents rated whether they would have rejected or accepted the main point of each argument, whether the main point of the argument seemed illusory or realistic, and whether the emotion evoked by the argument was destructive or constructive. The analysis of the data aimed at determining which within subject and between subject design factors were relevant in predicting respondents' acceptance of arguments and the

  7. Thermally favourable gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Dalianis, Ioannis, E-mail: Ioannis.Dalianis@fuw.edu.p [Institute of Theoretical Physics, Faculty of Physics, University of Warsaw, ul. Hoza 69, Warsaw (Poland); Lalak, Zygmunt, E-mail: Zygmunt.Lalak@fuw.edu.p [Institute of Theoretical Physics, Faculty of Physics, University of Warsaw, ul. Hoza 69, Warsaw (Poland)

    2011-03-14

    We discuss the thermal evolution of the spurion and messenger fields of ordinary gauge mediation models taking into account the Standard Model degrees of freedom. It is shown that for thermalized messengers the metastable susy breaking vacuum becomes thermally selected provided that the susy breaking sector is sufficiently weakly coupled to messengers or to any other observable field.

  8. Mobility into favourable jobs

    OpenAIRE

    Maurice Gesthuizen; Jaco Dagevos

    2005-01-01

    Original title: Arbeidsmobiliteit in goede banen. Hundreds of thousands of employees change jobs each year. Why do they do this, and what benefits do they derive from it? Many employees are not in the right jobs. Job dissatisfaction is found to be a key reason for labour mobility. These employees look for a job that offers a better match for their capacities and preferences. Does changing their job have a positive effect? This report shows that labour mobility does indeed generally lead to a ...

  9. Mobility into favourable jobs

    NARCIS (Netherlands)

    Maurice Gesthuizen; Jaco Dagevos

    2005-01-01

    Original title: Arbeidsmobiliteit in goede banen. Hundreds of thousands of employees change jobs each year. Why do they do this, and what benefits do they derive from it? Many employees are not in the right jobs. Job dissatisfaction is found to be a key reason for labour mobility. These employees

  10. Hindered aryl bromides for regioselective palladium-catalysed direct arylation at less favourable C5-carbon of 3-substituted thiophenes

    Directory of Open Access Journals (Sweden)

    Rongwei Jin

    2014-05-01

    Full Text Available The use of the congested aryl bromide 2-bromo-1,3-dichlorobenzene as coupling partner allows to modify the regioselectivity of the arylation of 3-substituted thiophene derivatives in favour of carbon C5. The coupling of this aryl bromide with a variety of 3-substituted thiophenes gave in all cases the desired 5-arylation products in moderate to good yields using only 0.5 mol % of a phosphine-free and air-stable palladium catalyst. Then, from these 5-arylthiophenes, a second palladium-catalysed C–H bond functionalization at C2 of the thiophene ring allows the synthesis of 2,5-diarylthiophenes with two different aryl units.

  11. RNA editing and modifications of RNAs might have favoured the evolution of the triplet genetic code from an ennuplet code.

    Science.gov (United States)

    Di Giulio, Massimo; Moracci, Marco; Cobucci-Ponzano, Beatrice

    2014-10-21

    Here we suggest that the origin of the genetic code, that is to say, the birth of first mRNAs has been triggered by means of a widespread modification of all RNAs (proto-mRNAs and proto-tRNAs), as today observed in the RNA editing and in post-transcriptional modifications of RNAs, which are considered as fossils of this evolutionary stage of the genetic code origin. We consider also that other mechanisms, such as the trans-translation and ribosome frameshifting, could have favoured the transition from an ennuplet code to a triplet code. Therefore, according to our hypothesis all these mechanisms would be reflexive of this period of the evolutionary history of the genetic code. Copyright © 2014. Published by Elsevier Ltd.

  12. Dravet syndrome with favourable cognitive and behavioral development due to a novel SCN1A frameshift mutation.

    Science.gov (United States)

    Jiang, Peifang; Shen, Jue; Yu, Yonglin; Jiang, Lihua; Xu, Jialu; Xu, Lu; Yu, Huimin; Gao, Feng

    2016-07-01

    Children with Dravet syndrome (DS) often have severe cognitive, behaviour and motor impairments. Patients with truncating mutations would logically have the more severe phenotype. Here we present a case of DS with an unusually favourable cognitive and behavioral development with a novel SCN1A frameshift mutation (c.4233-4234insAT). Under regular following up for ten years, the patient had normal expressive language and mild motor clumsiness. It is suggested that besides the type of SCN1A mutation, other mechanisms may be existed to influence the SCN1A phenotype, such as modifier genes, developmental variability, accumulation of somatic mutation in lifetime and environmental insults can all contribute to the cognitive and behavioral outcome.

  13. Cost-minimization analysis favours intravenous ferric carboxymaltose over ferric sucrose for the ambulatory treatment of severe iron deficiency.

    Directory of Open Access Journals (Sweden)

    Xavier Calvet

    Full Text Available OBJECTIVE: Intravenous iron is widely used to treat iron deficiency in day-care units. Ferric carboxymaltose (FCM allows administration of larger iron doses than iron sucrose (IS in each infusion (1000 mg vs. 200 mg. As FCM reduces the number of infusions required but is more expensive, we performed a cost-minimization analysis to compare the cost impact of the two drugs. MATERIALS AND METHODS: The number of infusions and the iron dose of 111 consecutive patients who received intravenous iron at a gastrointestinal diseases day-care unit from 8/2007 to 7/2008 were retrospectively obtained. Costs of intravenous iron drugs were obtained from the Spanish regulatory agencies. The accounting department of the Hospital determined hospital direct and indirect costs for outpatient iron infusion. Non-hospital direct costs were calculated on the basis of patient interviews. In the pharmacoeconomic model, base case mean costs per patient were calculated for administering 1000 mg of iron per infusion using FCM or 200 mg using IS. Sensitivity analysis and Monte Carlo simulation were performed. RESULTS: Under baseline assumptions, the estimated cost of iron infusion per patient and year was €304 for IS and €274 for FCM, a difference of €30 in favour of FCM. Adding non-hospital direct costs to the model increased the difference to €67 (€354 for IS vs. €287 for FCM. A Monte Carlo simulation taking into account non-hospital direct costs favoured the use of FCM in 97% of simulations. CONCLUSION: In this pharmacoeconomic analysis, FCM infusion reduced the costs of iron infusion at a gastrointestinal day-care unit.

  14. Exercise training favourably affects autonomic and blood pressure responses during mental and physical stressors in African-American men.

    Science.gov (United States)

    Bond, V; Bartels, M N; Sloan, R P; Millis, R M; Zion, A S; Andrews, N; De Meersman, R E

    2009-04-01

    Aerobic exercise is a powerful mechanism by which cardiovascular and autonomic parameters may be improved. We sought to quantify the extent of benefit that could be achieved by a short-term monitored exercise regimen on several autonomic parameters during recognized mental and physical stressors in young normotensive African-American men matched for a family history of hypertension, a group at high risk for the development of hypertension. Autonomic modulations were derived using spectral decomposition of the electrocardiogram and beat-to-beat blood pressures (BPs). Arterial compliance was obtained using contour analysis of the radial artery pulse wave. The analysis of variance revealed that compared with a matched sedentary control group, aerobic capacity of the trained group significantly increased by 16%. Autonomic modulations, arterial compliance and BP responses significantly improved during some of the stressors, whereas no such improvements were seen in the control group. Attenuated responses, mediated through a favourable shift in sympathovagal balance and enhanced arterial compliance, provide mechanistic evidence of how certain variables may be improved due to aerobic conditioning in a population at high risk for the development of hypertension.

  15. Post-fire environments are favourable for plant functioning of seeder and resprouter Mediterranean shrubs, even under drought.

    Science.gov (United States)

    Parra, Antonio; Moreno, José M

    2017-05-01

    Understanding how drought affects seeder and resprouter plants during post-fire regeneration is important for the anticipation of Mediterranean vegetation vulnerability in a context of increasing drought and fire caused by climate change. A Mediterranean shrubland was subjected to various drought treatments (including 45% rainfall reduction, 7 months drought yr(-1) ), before and after experimental burning, by means of a rainout-shelter system with an irrigation facility. Predawn shoot water potential (Ψpd ), relative growth rate (RGR), specific leaf area (SLA) and bulk leaf carbon isotopic composition (δ(13) C) were monitored in the main woody species during the first 3 yr after fire. Cistus ladanifer seedlings showed higher Ψpd , RGR and SLA, and lower δ(13) C, than unburned plants during the first two post-fire years. Seedlings under drought maintained relatively high Ψpd , but suffered a decrease in Ψpd and RGR, and an increase in δ(13) C, relative to control treatments. Erica arborea, E. scoparia and Phillyrea angustifolia resprouts had higher Ψpd and RGR than unburned plants during the first post-fire year. Resprouters were largely unaffected by drought. Overall, despite marked differences between the two functional groups, post-fire environments were favourable for plant functioning of both seeder and resprouter shrubs, even under the most severe drought conditions implemented. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  16. Mortality of the elderly is still exceedingly high at diagnosis of AIDS despite favourable outcomes after highly active antiretroviral therapy in Recife, Brazil.

    Science.gov (United States)

    Lacerda, H R; Kitner, D

    2008-07-01

    This study aimed to compare the outcome of an elderly group of AIDS patients with that of a younger group and their features at the time of the diagnosis of AIDS. We evaluated 58 patients aged >60 years and 114 aged 20-39 years, followed for 35.3 months. There was an obvious delay in diagnosing the elderly as they had more AIDS-defining diseases at diagnosis and their most frequent opportunistic infection was pulmonary tuberculosis. Mortality at the time of the diagnosis of AIDS was four times higher in the elderly (24.1% versus 6.1%, P therapy, there was a similar frequency of favourable outcomes; 76.9% in the elderly against 83.1% in the young (P = 0.455). Mean CD4 lymphocyte was 438 cells/mm(3) at the end of follow up in the young when compared with 442 cells/mm(3) in the elderly (P = 0.945). The types of antiretroviral schema and the number of antivirals per patient were similar in both groups.

  17. Dipeptidylpeptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) receptor agonists: yes.

    Science.gov (United States)

    Scheen, André J

    2012-03-01

    The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since the availability of incretin-based therapies. Compared with other glucose-lowering strategies, these novel drugs offer some advantages such as an absence of weight gain and a negligible risk of hypoglycaemia and, possibly, better cardiovascular and β-cell protection. The physician has now multiple choices to manage his/her patient after secondary failure of metformin, and the question whether it is preferable to add an oral dipeptidylpeptidase-4 (DPP-4) inhibitor (gliptin) or an injectable glucagon-like peptide-1 (GLP-1) receptor agonist will emerge. Obviously, DPP-4 inhibitors offer several advantages compared with GLP-1 receptor agonists, especially regarding easiness of use, tolerance profile and cost. However, because they can only increase endogenous GLP-1 concentrations to physiological (rather than pharmacological) levels, they are less potent to improve glucose control, promote weight reduction ("weight neutrality") and reduce blood pressure compared to GLP-1 receptor agonists. Of note, none of the two classes have proven long-term safety and positive impact on diabetic complications yet. The role of DPP-4 inhibitors and GLP-1 receptor agonists in the therapeutic armamentarium of T2DM is rapidly evolving, but their respective potential strengths and weaknesses should be better defined in long-term head-to-head comparative controlled trials. Instead of trying to answer the question whether DPP-4 inhibitors are favourable to GLP-1 receptor agonists (or vice versa), it is probably more clinically relevant to look at which T2DM patient will benefit more from one or the other therapy considering all his/her individual clinical characteristics ("personalized medicine").

  18. Favouring NO over H2O2 production will increase Pb tolerance in Prosopis farcta via altered primary metabolism.

    Science.gov (United States)

    Zafari, Somaieh; Sharifi, Mohsen; Mur, Luis A J; Chashmi, Najmeh Ahmadian

    2017-08-01

    Reactive oxygen species (ROS) and nitric oxide (NO) are known in triggering defense functions to detoxify heavy metal stresses. To investigate the relevance of ROS production, Pb treatment (400µM) alone and in combination with 400µM sodium ascorbate (Asc: as H2O2 scavenger) were given to hydroponically grown Prosopis farcta seedlings over a time course of 72h. Data presented here indicate that, the low extent of H2O2 due to scavenging by ascorbate, together with high level of NO improved Pb+Asc- treated Prosopis growth. Following the evoked potential of both the signals, significant increases in phenolic acids; caffeic, ferulic and salicylic acid were observed with Pb treatment; which are consistent with observed increase in lignin content and consequently with growth inhibition. In contrast, Pb+Asc treatment induced more flavonoids (quercetin, kaempferol, luteolin), diminished phenolic acids contents and also lignin. Elicited expression rate of phenylalanine ammonia-lyase gene (PAL) and also its enzymatic activity verified the induced phenylpropanoid metabolism by Pb and Pb+Asc treatments. In comparison with Pb stress, Asc+Pb application induced the high expression of arginine decarboxylase gene (ADC), in polyamines biosynthesis pathway, and conducted the N flow towards polyamines and γ-amino butyric acid (GABA). Examining the impact on enzyme activities, catalase, and guaiacol peroxidase; Pb+Asc reduced activity but this increased ascorbate peroxidase, and aconitase activity. Our observations are consistent with conditions favouring NO production and reduced H2O2 can improve Pb tolerance via wide-ranging effects on a primary metabolic network. Copyright © 2017. Published by Elsevier Inc.

  19. APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein.

    Science.gov (United States)

    Chalmers, K; Wilcock, G K; Love, S

    2003-06-01

    The relative amounts of amyloid beta-protein (A beta) in cerebral blood vessels and parenchyma vary considerably amongst patients with Alzheimer's disease (AD). Although several mechanisms have been proposed to explain this variability, the underlying genetic and environmental determinants are still unclear, as are the functional consequences. Polymorphisms in APOE, the gene for apolipoprotein E (ApoE), influence the risk of developing AD and of deposition of A beta within the brain. We examined the relationship between the APOE genotype and the relative extent of accumulation of A beta as plaques within the cerebral parenchyma and in cortical blood vessels in the form of cerebral amyloid angiopathy (CAA), in autopsy brain tissue from 125 AD cases and from 53 elderly, neurologically normal controls of which 19 had CAA without other neuropathological features of AD. In the AD cases, we also assessed whether the severity of CAA was related to the age of onset and duration of dementia, risk factors for atherosclerotic vascular disease, and histologically demonstrable cerebral infarcts or foci of haemorrhage. The APOE genotype was determined by a standard polymerase chain reaction-based method. Paraffin sections of frontal, temporal and parietal lobes were immunolabelled for A beta and the parenchymal A beta load (total A beta minus vessel-associated A beta) was quantified by computer-assisted image analysis. CAA severity was scored for cortical and leptomeningeal vessels. The relevant clinical data were obtained from the database of the South West Brain Bank. In AD, we found the severity of CAA to be strongly associated with the number of epsilon 4 alleles (P possession of the APOE epsilon 4 allele favours vascular over parenchymal accumulation of A beta in AD. This may influence the pathogenesis of neurodegeneration in epsilon 4-associated AD.

  20. Class Teachers – Their Thinking and Reasoning in the Context of Creating a Favourable Classroom Social Climate by Means of the Methods of Personal and Social Education

    Directory of Open Access Journals (Sweden)

    Geršicová Zuzana

    2016-06-01

    Full Text Available The paper deals with class teachers’ thinking and reasoning processes and the possibilities of influencing teachers’ ability to create a favourable classroom social climate. This paper describes personal and social education as one of the means and methods of such influencing. The results of the research carried out indicate that teachers have a very high opinion regarding their ability to create a favourable classroom social climate. The issues of personal and social education in the work of a class teacher are the topic of the project KEGA 002DTI-4/2013 being solved by a team of professionals at Dubnica Institute of Technology in Dubnica nad Váhom.

  1. Digital mapping of soil related common European biophysical criteria used for the identification of Less Favoured Areas in Hungary

    Science.gov (United States)

    Pásztor, László; Szabó, József; Bakacsi, Zsófia

    2010-05-01

    One of the main objectives of the EU's Common Agricultural Policy is to encourage maintaining agricultural production in less favoured areas (LFA) in order to sustain agricultural production and use natural resources, in such a way to secure both stable production and income to farmers and to protect the environment. LFA assignment has both ecological and severe economical aspects. Recently the delimitation of LFAs is suggested to be carried out by using common biophysical diagnostic criteria on low soil productivity and poor climate conditions all over Europe. The criterion system was elaborated by JRC and its operational implementation comes under member state competence. This process requires the existence of an adequate national spatial soil information system with appropriate data structure and spatial resolution as well as a proper methodology for its analysis. Hungary possesses an appropriate nationwide, 1:25,000 scale legacy data set originating from the national soil mapping project, which was initiated and led by Kreybig. This national survey was based on field and laboratory soil analyses and at the same time serving practical purposes. Its objective was the preparation of a map series which gives an insight to the geographical site and extent of soil conditions and soil properties for the production directing authorities, agricultural policy-makers, farmers, and the research institutes related to production problems. The similarity between the objectives of the old national mapping and those of the present European activities is remarkable. In the fifties, when the survey was completed, Hungary was the first in the world to have 1:25,000 scale soil information for the whole country. Overall chemical and physical soil properties of the soil root zone featuring soil patches were identified for croplands. Three characteristics were attributed to soil mapping units and displayed on the maps; further soil properties were determined and measured in soil

  2. International Implications: Are Polish Higher School Learners in Favour of Darwin's Theory of Evolution Being Taught in Primary and Secondary Schools?

    Science.gov (United States)

    Butler, Norman L.; Griffith, Kimberly Grantham; Kritsonis, William Allan

    2007-01-01

    The purpose of this article is to determine if Polish higher school learners are in favour of Darwin's evolutionary theory being included in the primary and secondary school curriculum. Thirty three students at AGH University of Science and Technology, Poland were surveyed, and the author found that all of them are in agreement with it. The…

  3. Pregnancy may favour the development of severe autoimmune central diabetes insipidus in women with vasopressin cell antibodies: description of two cases.

    Science.gov (United States)

    Bellastella, Giuseppe; Bizzarro, Antonio; Aitella, Ernesto; Barrasso, Mariluce; Cozzolino, Domenico; Di Martino, Sergio; Esposito, Katherine; De Bellis, Annamaria

    2015-03-01

    Recently, an increased incidence of central diabetes insipidus (CDI) in pregnancy, and less frequently in the post partum period, has been reported, most probably favoured by some conditions occurring in pregnancy. This study was aimed at investigating the influence of pregnancy on a pre-existing potential/subclinical hypothalamic autoimmunity. We studied the longitudinal behaviour of arginine-vasopressin cell antibodies (AVPcAbs) and post-pituitary function in two young women with a positive history of autoimmune disease and presence of AVPcAbs, but without clinical CDI, and who became pregnant 5 and 7 months after our first observation. The behaviour of post-pituitary function and AVPcAbs (by immunofluorescence) was evaluated at baseline, during pregnancy and for 2 years after delivery. AVPcAbs, present at low/middle titres at baseline in both patients, showed a titre increase during pregnancy in one patient and after delivery in the other patient, with development of clinically overt CDI. Therapy with 1-deamino-8-d-arginine vasopressin (DDAVP) caused a prompt clinical remission. After a first unsuccessful attempt of withdrawal, the therapy was definitively stopped at the 6th and the 7th month of post partum period respectively, when AVPcAbs disappeared, accompanied by post-pituitary function recovery, persisting until the end of the follow-up. The determination of AVPcAbs is advisable in patients with autoimmune diseases planning their pregnancy, because they could be considered good predictive markers of gestational or post partum autoimmune CDI. The monitoring of AVPcAb titres and post-pituitary function during pregnancy in these patients may allow for an early diagnosis and an early replacement therapy, which could induce the disappearance of these antibodies with consequent complete remission of CDI.

  4. CD3+, CD4+ & CD8+ tumour infiltrating lymphocytes (TILs are predictors of favourable survival outcome in infiltrating ductal carcinoma of breast

    Directory of Open Access Journals (Sweden)

    Ankita Singh Rathore

    2014-01-01

    Full Text Available Background & objectives: Tumour infiltrating lymphocytes (TILs represent the host immune response against cancer cells associated with good or bad prognosis in different tumour types. This study was undertaken to evaluate the significance of CD3+, CD4+ and CD8+ TILs in breast cancer tissues in relation to clinico-pathological variables and survival outcome. Methods: Immunohistochemistry (IHC was performed with antibodies against CD3, CD4 and CD8 antigens on formalin-fixed paraffin-embedded tissue sections of 150 breast cancer patients. Intratumoural and stromal TIL counting was performed semiquantitatively. Results: The higher CD3+, CD4+ and CD8+ intratumoural and stromal counts showed independent and direct association with good prognosis. The prognostic predictor value of intratumoural counts was higher than stromal counts. The independent associations of intratumoural and stromal counts became more prominent when adjusted with stage and grade, respectively. Among intratumoural counts, the high (++/+++ CD4+ count (OR=3.85, 95% CI=3.28-16.71, P<0.001 showed the highest survival followed by CD3+ (OR=2.70, 95% CI=1.76-8.30, P=0.001 and CD8+ (OR=2.58, 95% CI=1.55-5.86, p0 =0.001 the least when compared to respective low (+ counts. In contrast, among stromal counts, the high CD8+ count (OR=3.13, 95% CI=2.20-9.57, p0 <0.001 showed the highest survival followed by CD4+ (OR=3.02, 95% CI=2.07-8.89, p0 <0.001 and CD3+ (OR=2.45, 95% CI=1.53-6.73, p0 =0.002 the least. Interpretation & conclusions: Our results suggest that intratumoural CD4+ and stromal CD8+ counts by immunohistochemistry may serve as an independent prognosticator for favourable outcome in breast cancer.

  5. OBSERVING OF RADIOACTIVE CAESIUM 137Cs VALUE IN BEEF MEAT (CZECH PIED CATTLE IN LESS-FAVOURED AREAS OF THE CZECH REPUBLIC

    Directory of Open Access Journals (Sweden)

    Ivan Holko

    2012-02-01

    Full Text Available Value of radiocaesium 137Cs as one of Risk Factors in beef meat is very important for human health. Beef meat (m. longissimus lumborum et thoracis from Czech Pied cattle in two less-favoured areas located more then 500 meters above sea level (Bohemian Forest Bohemian and Moravian Highland was dependent on Sex (decrease by female, increase by male, P<1.10-6 and on area (P<1.10-6. Value of radiocaesium 137Cs in beef meat ( = 0,42 Bq.kg-1; sx = 0,28 was less then food standard (600 Bq.kg-1. This observed result are responding to finding another authors and could be used for next more detailed research in optimal utilization of Czech Pied cattle in less-favoured areas.

  6. Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation

    DEFF Research Database (Denmark)

    Milman, Nils; Andersen, Claus B; Hansen, Annette

    2006-01-01

    quality of life. At follow up at 20 years of age (after 2-5 years of infliximab treatment) the twins had an almost normal physical appearance and a normal psychomotoric development, indicating a favourable short-term prognosis of the disease. Blau syndrome has pathologic, clinical and therapeutic features...... in common with sarcoidosis, but rarely involves the lungs or other parenchymatous organs. In children, discrimination between early onset sarcoidosis and Blau syndrome should include a CARD15 mutation analysis....

  7. The most-favoured-nation clause in tax treaties: tool for potential reduction of withholding income tax applicable to Chile and Canada

    OpenAIRE

    Renée Antonieta Villagra Cayamana; Jorge Antonio Villagra Cayamana

    2013-01-01

    Tax treaties to avoid the double taxation signed by a country have consequences for the future, but they can also modify the terms of treaties that are already in force, in case these contain most-favoured-nation clauses. In this line, taxpayers and companies, particularly, as well as the Tax Administration must be alert, regarding topotential modifications of the terms of the Peruvian tax treaties already in force; mainly about the withholding tax rate applied to royalties in the Convention ...

  8. Changes in vector species composition and current vector biology and behaviour will favour malaria elimination in Santa Isabel Province, Solomon Islands

    Directory of Open Access Journals (Sweden)

    Beebe Nigel W

    2011-09-01

    Full Text Available Abstract Background In 2009, Santa Isabel Province in the Solomon Islands embarked on a malaria elimination programme. However, very little is known in the Province about the anopheline fauna, which species are vectors, their bionomics and how they may respond to intensified intervention measures. The purpose of this study was to provide baseline data on the malaria vectors and to ascertain the possibility of successfully eliminating malaria using the existing conventional vector control measures, such as indoor residual spraying (IRS and long-lasting insecticidal nets (LLIN. Methods Entomological surveys were undertaken during October 2009. To determine species composition and distribution larval surveys were conducted across on the whole island. For malaria transmission studies, adult anophelines were sampled using human landing catches from two villages - one coastal and one inland. Results Five Anopheles species were found on Santa Isabel: Anopheles farauti, Anopheles hinesorum, Anopheles lungae, Anopheles solomonis, and Anopheles nataliae. Anopheles hinesorum was the most widespread species. Anopheles farauti was abundant, but found only on the coast. Anopheles punctulatus and Anopheles koliensis were not found. Anopheles farauti was the only species found biting in the coastal village, it was incriminated as a vector in this study; it fed early in the night but equally so indoors and outdoors, and had a low survival rate. Anopheles solomonis was the main species biting humans in the inland village, it was extremely exophagic, with low survival rates, and readily fed on pigs. Conclusion The disappearance of the two major vectors, An. punctulatus and An. koliensis, from Santa Isabel and the predominance of An. hinesorum, a non-vector species may facilitate malaria elimination measures. Anopheles farauti was identified as the main coastal vector with An. solomonis as a possible inland vector. The behaviour of An. solomonis is novel as it has

  9. The most-favoured-nation clause in tax treaties: tool for potential reduction of withholding income tax applicable to Chile and Canada

    Directory of Open Access Journals (Sweden)

    Renée Antonieta Villagra Cayamana

    2013-07-01

    Full Text Available Tax treaties to avoid the double taxation signed by a country have consequences for the future, but they can also modify the terms of treaties that are already in force, in case these contain most-favoured-nation clauses. In this line, taxpayers and companies, particularly, as well as the Tax Administration must be alert, regarding topotential modifications of the terms of the Peruvian tax treaties already in force; mainly about the withholding tax rate applied to royalties in the Convention subscribed with Chile and the withholding tax rates applied to dividends, interests and royalties in the Convention subscribed with Canada, taking into account that both of the mentioned tax treaties contain most-favoured-nation clauses for those kind of income. The Ministry of Economy, as the entity in charge of negotiations of the bilateral conventions, according to Law Decree 25883, has the responsibility of negotiating future treaties with full knowledge that the terms to be included could also cause the effect to decrease the withholding tax rates of the income tax in respect to conventions already in effect, as a consequence of the most-favoured-nation clause they contain.

  10. Informal caregiving as a risk factor for type 2 diabetes in individuals with favourable and unfavourable psychosocial work environments

    DEFF Research Database (Denmark)

    Mortensen, J; Clark, Adrian J L; Lange, T.

    2017-01-01

    Longitudinal Occupational Survey of Health (SLOSH) and the British Whitehall II study-a total of 21,243 study subjects. Informal caregiving was defined as unpaid care for a closely related person. Job strain was assessed using the demand-control model, and questions on co-worker and supervisor support were...

  11. Kinerja Keuangan dan Internet Financial Reporting Index (IFRI: Sebuah Studi Relevansi Pada Sektor Perbankan Syariah di Kawasan ASEAN

    Directory of Open Access Journals (Sweden)

    Imanda Firmantyas Putri Pertiwi

    2017-06-01

    Full Text Available This study aimed to assess the effect of Islamic Banks financial performance according to the Risk Profile, Good Corporate Governance, Earnings and Capital (RGEC on the disclosure of financial performance through the company’s website or being known as Internet Financial Reporting Index (IFRI. Taking Islamic banks across the ASEAN region as target of the research, this study result the conclusion that profitability ratios and nonperforming finance are two things that do not affect the index of internet financial report. While CAR and FDR show significant impacts on the index of IFR. These results have been proven their robustnesses. Control variables was added to the model and the results obtained did not change significantly. The total number of Islamic banks in the ASEAN region are 32 banks. Twelve Islamic banks are in Indonesia, 16 in Malaysia, one in the Philippines, one in Thailand and two in Brunei Darussalam. One bank in Brunei being canceled due to incomplete information. The method used in this research is multiple linear regression, furthermore control variables was added to reduce the bias of the research results.

  12. Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma

    Directory of Open Access Journals (Sweden)

    Mehl Erika

    2007-11-01

    Full Text Available Abstract Background Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in model systems. The latter might suggest that their overexpression would be associated with a better prognosis in cancer. However, kisspeptin/GPR54 interactions (autocrine, paracrine, and/or endocrine could also impact tumour behaviour in a negative manner. Here, for the first time, we associate the immunoreactivity of the kisspeptin/GPR54 ligand-receptor pair with favourable prognosis in a large cohort of ovarian carcinomas. Methods Immunohistochemical analysis for kisspeptin and GPR54 was performed on a tissue microarray (TMA consisting of 518 early stage ovarian carcinomas, all with linked clinical outcome data. The TMA was scored using a staining intensity scale of 0 (negative, +1 (mild-moderate, and +2 (strong. Strong staining cases were considered either kisspeptin or GPR54 positive and designated as 1, while all other cases were considered negative and designated 0. All statistical analysis was conducted using two-sided tests and a p value equal to or less than 0.05 was considered significant. Results Kisspeptin and GPR54 immunoreactive cases show a favourable prognosis in univariable disease specific survival (p = 0.0023, p = 0.0092, as well as in overall survival (p = 0.0006, p = 0.0002. Furthermore, kisspeptin is an independent marker for favourable prognosis as determined by multivariable disease specific (p = 0.0046 and overall survival analysis (p = 0.0170, while GPR54 is an independent marker for overall survival only (p = 0.0303. Both kisspeptin positive and GPR54 positive cases are strongly associated with the ovarian carcinoma clear cell subtype (p Conclusion Kisspeptin and GPR54 immunoreactivity are significantly associated with favourable prognosis in both disease specific and overall survival, as well as being significantly associated with the clear

  13. Evidence from the UK Zoonoses Action Plan in favour of localised anomalies of Salmonella infection on United Kingdom pig farms.

    Science.gov (United States)

    Clough, Helen E; Fenton, Sarah E; French, Nigel P; Miller, Alexander J; Cook, Alasdair J C

    2009-05-01

    Salmonella spp. are important food-borne pathogens. Abattoir studies demonstrated that almost a quarter of British finisher pigs might carry Salmonella, which led to the introduction by the British Pig Executive of their Zoonoses Action Plan (ZAP) to monitor the Salmonella status of United Kingdom pig farms by testing meat juice samples using an ELISA system. We used the K-function and approaches from the field of geostatistics to study routine data from ZAP. We demonstrated that there is statistical evidence that geographically localized anomalies of Salmonella infection were present in one of three regions studied. The physical mechanisms underlying this structure remain unclear: spatial structure might be present as a result of shared spatially structured (second-order) or non-spatially structured (first-order) risk factors, transmission processes, or a combination of both. We have demonstrated a way to use routinely collected surveillance data to enhance the knowledge of spatial disease epidemiology.

  14. Implicit self-esteem and social anxiety : differential self-favouring effects in high and low anxious individuals

    NARCIS (Netherlands)

    de Jong, Peter

    2002-01-01

    This study was designed to investigate the role of negative self-image in social phobia. Participants were 19 high and 19 low socially anxious women. Because self-report measures of self-esteem are sensitive to self-presentation and impression management strategies, an implicit association test (IAT

  15. The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release

    OpenAIRE

    Escudero, Claudia A; Lazo, Oscal M.; Galleguillos, Carolina; Parraguez, Jose I.; Lopez-Verrilli, Maria A.; Cabeza, Carolina; Leon, Luisa; Saeed, Uzma; Retamal, Claudio; Gonzalez, Alfonso; Marzolo, Maria-Paz; Bruce D Carter; Court, Felipe A.; Bronfman, Francisca C.

    2014-01-01

    The p75 neurotrophin receptor (p75, also known as NGFR) is a multifaceted signalling receptor that regulates neuronal physiology, including neurite outgrowth, and survival and death decisions. A key cellular aspect regulating neurotrophin signalling is the intracellular trafficking of their receptors; however, the post-endocytic trafficking of p75 is poorly defined. We used sympathetic neurons and rat PC12 cells to study the mechanism of internalisation and post-endocytic trafficking of p75. ...

  16. Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT promoter methylation as independent favourable prognostic factor

    Directory of Open Access Journals (Sweden)

    Smrdel Uros

    2016-12-01

    Full Text Available In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status do not clearly predict long-term survival. The aim of this case-control study was to evaluate immuno-histochemical and genetic characteristics of the tumour as additional prognostic factors in glioblastoma.

  17. Melanoma patients with unknown primary site or nodal recurrence after initial diagnosis have a favourable survival compared to those with synchronous lymph node metastasis and primary tumour.

    Directory of Open Access Journals (Sweden)

    Benjamin Weide

    Full Text Available BACKGROUND: A direct comparison of prognosis between patients with regional lymph node metastases (LNM detected synchronously with the primary melanoma (primary LNM, patients who developed their first LNM subsequently (secondary LNM and those with initial LNM in melanoma with unknown primary site (MUP is missing thus far. PATIENTS AND METHODS: Survival of 498 patients was calculated from the time point of the first macroscopic LNM using Kaplan Meier and multivariate Cox hazard regression analysis. RESULTS: Patients with secondary LNM (HR = 0.67; p = 0.009 and those with initial LNM in MUP (HR = 0.45; p = 0.008 had a better prognosis compared to patients with primary LNM (median survival time 52 and 65 vs. 24 months, respectively. A high number of involved nodes, the presence of in-transit/satellite metastases and male gender had an additional independent unfavourable effect. CONCLUSIONS: Survival of patients with LNM in MUP and with secondary LNM is similar and considerably more favourable compared to those with primary LNM. This difference needs to be considered during patient counselling and for stratification purposes in clinical trials. The assumption of an immune privilege of patients with MUP which is responsible for rejection of the primary melanoma, and results in a favourable prognosis is not supported by our data.

  18. Predation success by a plant-ant indirectly favours the growth and fitness of its host myrmecophyte.

    Directory of Open Access Journals (Sweden)

    Alain Dejean

    Full Text Available Mutualisms, or interactions between species that lead to net fitness benefits for each species involved, are stable and ubiquitous in nature mostly due to "byproduct benefits" stemming from the intrinsic traits of one partner that generate an indirect and positive outcome for the other. Here we verify if myrmecotrophy (where plants obtain nutrients from the refuse of their associated ants can explain the stability of the tripartite association between the myrmecophyte Hirtella physophora, the ant Allomerus decemarticulatus and an Ascomycota fungus. The plant shelters and provides the ants with extrafloral nectar. The ants protect the plant from herbivores and integrate the fungus into the construction of a trap that they use to capture prey; they also provide the fungus and their host plant with nutrients. During a 9-month field study, we over-provisioned experimental ant colonies with insects, enhancing colony fitness (i.e., more winged females were produced. The rate of partial castration of the host plant, previously demonstrated, was not influenced by the experiment. Experimental plants showed higher δ(15N values (confirming myrmecotrophy, plus enhanced vegetative growth (e.g., more leaves produced increased the possibility of lodging ants in leaf pouches and fitness (i.e., more fruits produced and more flowers that matured into fruit. This study highlights the importance of myrmecotrophy on host plant fitness and the stability of ant-myrmecophyte mutualisms.

  19. “Changing in favour of the team”: the collective dimension in the work of beach volleyball athletes

    Directory of Open Access Journals (Sweden)

    Louise Borba

    2017-07-01

    Full Text Available Thinking on the collective dimension of sports as a division of functions among athletes within a team may limit and conceal all the existing debates and dramas in such work activity. Thus, the aim of the present study is to assess how autonomous beach volleyball athletes manage their professional lives in the search for partners to form a pair who fits for “playing together”, although the work organisation in the aforementioned modality is extremely competitive and requires high turnover of its members. Based on Ergology, Ergonomics and Clinic Activity, we assume that athletes are required to put their sportive competences in synergy to form a pair, or to set up a team. Besides, above all, we expected these athletes to be able to build cognitive references, as well as common values, which enable communication and cooperation within work development.

  20. [Endarterectomy more favourable than stenting in symptomatic significant carotid stenosis: higher risk of ischaemic stroke or death following stenting].

    Science.gov (United States)

    Meerwaldt, Robbert; Beuk, Roland J; Huisman, Ad B; Manschot, Sanne M; Zeebregts, Clark J; Geelkerken, Robert H

    2011-01-01

    Carotid endarterectomy (CEA) has proven its value in the treatment of patients with recent significant carotid artery stenosis. Percutaneous transluminal angioplasty with carotid artery stenting ('stenting' in short) is an alternative to CEA. The results of stenting and CEA in patients with symptomatic significant carotid artery stenosis were evaluated in 9 prospective randomized controlled trials and 11 meta-analyses. Almost all of these trials failed to show superiority of stenting to CEA. According to the 4 largest and most recent studies in this field the risk of a stroke or death within 30 days after the intervention is considerably higher following stenting than following CEA. In the long run the results of stenting and CEA seem to be comparable. CEA remains the gold standard in treatment of significant carotid artery stenosis, in particular in patients older than 70.

  1. Diffusion welding: a technology which is in favour; Soudage par diffusion. Une technologie qui a le vent en poupe

    Energy Technology Data Exchange (ETDEWEB)

    Macel, D. [Intitut de Soudure, 57 - Yutz (France)

    2009-01-15

    The aim of this work is to show the implication of the experimental parameters (welding temperature, temperature holding time, lining pressure, surface states, atmosphere) on the bonds quality. On the other hand, the feasibility of an homogeneous bond has been shown on two materials prepared by the Haynes firm: the HR-120 (iron-nickel-chromium alloy which has good properties at high temperature: 1100 C) and the HR-230 (other iron-nickel-chromium alloy which has a very good resistance at high temperature: until 1150 C and at oxidation too). The study of welding specimens by metallographic analysis allows to conclude to the establishment of healthy bonds, particularly if the experimental parameters are scrupulously respected. (O.M.)

  2. Coregistration of multimodal imaging is associated with favourable two-year seizure outcome after paediatric epilepsy surgery.

    Science.gov (United States)

    Perry, Michael Scott; Bailey, Laurie; Freedman, Daniel; Donahue, David; Malik, Saleem; Head, Hayden; Keator, Cynthia; Hernandez, Angel

    2017-03-01

    Multimodal coregistration uses multiple image datasets coregistered to an anatomical reference (i.e. MRI), allowing multiple studies to be viewed together. Commonly used in intractable epilepsy evaluation and generally accepted to improve localization of the epileptogenic zone, data showing that coregistration improves outcome is lacking. We compared seizure freedom following epilepsy surgery in paediatric patients, evaluated before and after the use of coregistration protocols at our centre, to determine whether this correlated with a change in outcome. We included paediatric epilepsy surgery patients with at least one anatomical and one functional neuroimaging study as part of their presurgical evaluation. Preoperatively designated palliative procedures and repeat surgeries were excluded. Multiple pre-, peri-, and postoperative variables were compared between groups with the primary outcome of seizure freedom. In total, 115 were included with an average age of 10.63 years (0.12-20.7). All evaluations included video-EEG (VEEG) and MRI. Seven (6%) had subtraction single-photon emission CT (SPECT), 46 (40%) had positron emission tomography (PET), and 62 (54%) had both as part of their evaluation. Sixty (52%) had extratemporal epilepsy and 25 (22%) were MRI-negative. Sixty-eight (59%) had coregistration. Coregistered patients were less likely to undergo invasive EEG monitoring (p=0.045) and were more likely to have seizure freedom at one (p=0.034) and two years (pseizure reduction compared to visual analysis of individual modalities. Imaging coregistration is associated with improved outcome, independent of other variables after surgery. Coregistered imaging may reduce the need for invasive EEG monitoring, likely due to improved confidence in presurgical localization. These findings support the use of multimodal coregistered imaging as part of the presurgical assessment in patients evaluated for surgical treatment of intractable epilepsy.

  3. Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer

    Directory of Open Access Journals (Sweden)

    Pasini Giuseppe

    2010-03-01

    Full Text Available Abstract Background The purpose of our study was to compare differences in the prognosis of breast cancer (BC patients at high (H risk or intermediate slightly (IS increased risk based on family history and those without a family history of BC, and to evaluate whether ten-year overall survival can be considered a good indicator of BRCA1 gene mutation. Methods We classified 5923 breast cancer patients registered between 1988 and 2006 at the Department of Oncology and Haematology in Modena, Italy, into one of three different risk categories according to Modena criteria. One thousand eleven patients at H and IS increased risk were tested for BRCA1/2 mutations. The overall survival (OS and disease free survival (DFS were the study end-points. Results Eighty BRCA1 carriers were identified. A statistically significantly better prognosis was observed for patients belonging to the H risk category with respect to women in the IS and sporadic groups (82% vs.75% vs.73%, respectively; p BRCA1 carriers with BRCA-negative and sporadic BC (77% vs.77% vs.73%, respectively; p Conclusions Patients belonging to a population with a high probability of being BRCA1 carriers had a better prognosis than those with sporadic BC. Considering these results, women who previously had BC and had survived ten years could be selected for BRCA1 analysis among family members at high risk of hereditary BC during genetic counselling. Since only 30% of patients with a high probability of having hereditary BC have BRCA1 mutations, selecting women with a long term survival among this population could increase the rate of positive analyses, avoiding the use of expensive tests.

  4. Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer

    LENUS (Irish Health Repository)

    Ehlen, Asa

    2010-08-20

    Abstract Background We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line. Methods RBM3 mRNA expression was analysed in tumors from a cohort of 267 EOC cases (Cohort I) and RBM3 protein expression was analysed using immunohistochemistry (IHC) in an independent cohort of 154 prospectively collected EOC cases (Cohort II). Kaplan Meier analysis and Cox proportional hazards modelling were applied to assess the relationship between RBM3 and recurrence free survival (RFS) and overall survival (OS). Immunoblotting and IHC were used to examine the expression of RBM3 in a cisplatin-resistant ovarian cancer cell line A2780-Cp70 and its cisplatin-responsive parental cell line A2780. The impact of RBM3 on cisplatin response in EOC was assessed using siRNA-mediated silencing of RBM3 in A2780 cells followed by cell viability assay and cell cycle analysis. Results Increased RBM3 mRNA expression was associated with a prolonged RFS (HR = 0.64, 95% CI = 0.47-0.86, p = 0.003) and OS (HR = 0.64, 95% CI = 0.44-0.95, p = 0.024) in Cohort I. Multivariate analysis confirmed that RBM3 mRNA expression was an independent predictor of a prolonged RFS, (HR = 0.61, 95% CI = 0.44-0.84, p = 0.003) and OS (HR = 0.62, 95% CI = 0.41-0.95; p = 0.028) in Cohort I. In Cohort II, RBM3 protein expression was associated with a prolonged OS (HR = 0.53, 95% CI = 0.35-0.79, p = 0.002) confirmed by multivariate analysis (HR = 0.61, 95% CI = 0.40-0.92, p = 0.017). RBM3 mRNA and protein expression levels were significantly higher in the cisplatin sensitive A2780 cell line compared to the cisplatin resistant A2780-Cp70 derivative. siRNA-mediated silencing of RBM3 expression in the A2780 cells resulted

  5. 20th century global warming favoured enhanced intensity of extreme torrential events - a proglacial sediment record in NW French Alps

    Science.gov (United States)

    Wilhelm, B.; Arnaud, F.; Legaz, A.; Allignol, F.; Enters, D.; Revillon, S.

    2009-04-01

    During the past few yeas, considerable climate changes have been observed at high elevation areas of the European Alps. Additionally, one of the main results of high resolution climate modelling is a trend towards both dryer summer conditions and enhanced risk of extreme floods. This should have particularly dramatic consequences in alpine areas. Indeed, the development of tourism during the 20th century in the Alps and the rise of population density resulted in an increasing potential risk from natural hazards. Among them, torrential floods are some of the most common and widespread ones. They cause both loss of human life and high damage to property and infrastructure and are particularly destructive in mountain areas. For example, in August 2005, an unusual meteorological situation resulted in a series of catastrophic floods in most regions of the European Alps and particularly in the catchment of the Vorz river, downstream of proglacial Lac Blanc (2170 m a.s.l., Belledonne range, NW French Alps). We studied a series of sediment cores from Lac Blanc, spanning the last ca. 250 years. Through a coupled high resolution sedimentological and geochemical approach we documented about 100 flood deposits and measured their thickness. The age of each deposit has been assessed by radiochemical dating and the recognition of historically-known events - major earthquakes and historical atmospheric lead deposition. Furthermore, a detailed study of regional and local historical archives was conducted allowing us to relate the recognised flood deposits to the ones reported by local population. We hence obtained a flood calendar from 1740 to 2005 with the respective intensity of each event assessed by the thickness of the associated deposit. The flood frequency shows an important and punctual increase at the early end of the Little Ice Age (1830 - 1860) as a response to the beginning warming period, which was emphasized by the synchronous local glacier retreat. On the other hand

  6. The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release

    Science.gov (United States)

    Escudero, Claudia A.; Lazo, Oscal M.; Galleguillos, Carolina; Parraguez, Jose I.; Lopez-Verrilli, Maria A.; Cabeza, Carolina; Leon, Luisa; Saeed, Uzma; Retamal, Claudio; Gonzalez, Alfonso; Marzolo, Maria-Paz; Carter, Bruce D.; Court, Felipe A.; Bronfman, Francisca C.

    2014-01-01

    ABSTRACT The p75 neurotrophin receptor (p75, also known as NGFR) is a multifaceted signalling receptor that regulates neuronal physiology, including neurite outgrowth, and survival and death decisions. A key cellular aspect regulating neurotrophin signalling is the intracellular trafficking of their receptors; however, the post-endocytic trafficking of p75 is poorly defined. We used sympathetic neurons and rat PC12 cells to study the mechanism of internalisation and post-endocytic trafficking of p75. We found that p75 internalisation depended on the clathrin adaptor protein AP2 and on dynamin. More surprisingly, p75 evaded the lysosomal route at the level of the early endosome, instead accumulating in two different types of endosomes, Rab11-positive endosomes and multivesicular bodies (MVBs) positive for CD63, a marker of the exosomal pathway. Consistently, depolarisation by KCl induced the liberation of previously endocytosed full-length p75 into the extracellular medium in exosomes. Thus, p75 defines a subpopulation of MVBs that does not mature to lysosomes and is available for exosomal release by neuronal cells. PMID:24569882

  7. High intensity interval training favourably affects antioxidant and inflammation mRNA expression in early-stage chronic kidney disease.

    Science.gov (United States)

    Tucker, Patrick S; Briskey, David R; Scanlan, Aaron T; Coombes, Jeff S; Dalbo, Vincent J

    2015-12-01

    Increased levels of oxidative stress and inflammation have been linked to the progression of chronic kidney disease. To reduce oxidative stress and inflammation related to chronic kidney disease, chronic aerobic exercise is often recommended. Data suggests high intensity interval training may be more beneficial than traditional aerobic exercise. However, appraisals of differing modes of exercise, along with explanations of mechanisms responsible for observed effects, are lacking. This study assessed effects of eight weeks of high intensity interval training (85% VO2max), versus low intensity exercise (45-50% VO2max) and sedentary behaviour, in an animal model of early-stage chronic kidney disease. We examined kidney-specific mRNA expression of genes related to endogenous antioxidant enzyme activity (glutathione peroxidase 1; Gpx1, superoxide dismutase 1; Sod1, and catalase; Cat) and inflammation (kidney injury molecule 1; Kim1 and tumour necrosis factor receptor super family 1b; Tnfrsf1b), as well as plasma F2-isoprostanes, a marker of lipid peroxidation. Compared to sedentary behaviour, high intensity interval training resulted in increased mRNA expression of Sod1 (p=0.01) and Cat (pinflammation.

  8. Nebular phase observations of the type-Ib supernova iPTF13bvn favour a binary progenitor

    CERN Document Server

    Kuncarayakti, H; Bersten, M C; Folatelli, G; Morrell, N; Hsiao, E Y; González-Gaitán, S; Anderson, J P; Hamuy, M; de Jaeger, T; Gutiérrez, C P; Kawabata, K S

    2015-01-01

    Aims. We present and analyse late-time observations of the type-Ib supernova with possible pre-supernova progenitor detection, iPTF13bvn, taken at $\\sim$300 days after the explosion, and discuss these in the context of constraints on the supernova's progenitor. Previous studies have proposed two possible natures for the progenitor of the supernova, i.e. a massive Wolf-Rayet star or a lower-mass star in close binary system. Methods. Our observations show that the supernova has entered the nebular phase, with the spectrum dominated by Mg~I]$\\lambda\\lambda$4571, [O~I]$\\lambda\\lambda$6300, 6364, and [Ca~II]$\\lambda\\lambda$7291, 7324 emission lines. We measured the emission line fluxes to estimate the core oxygen mass and compare the [O~I]/[Ca~II] line ratio with other supernovae. Results. The core oxygen mass of the supernova progenitor was estimated to be $\\lesssim$0.7 M$_\\odot$, which implies initial progenitor mass not exceeding $\\sim$15 -- 17 M$_\\odot$. Since the derived mass is too small for a single star to...

  9. The use of fibre-reinforced polymers (FRP in bridges as a favourable solution for the environment

    Directory of Open Access Journals (Sweden)

    Żyjewski Artur

    2017-01-01

    Full Text Available The purpose of this article is to show the modern engineering, in which sustainability and taking care of ecology play a significant role. The authors are focused on FRP composite materials and their applications in civil engineering. Case studies showing renovation and design of new bridges with the use of FRP are presented and discussed to clarify benefits, which this solution provides. Main advantages of FRP materials in comparison with traditional ones, like concrete or steel are showed. The environmental impact of composites is described with respect to all life cycle of a product. Furthermore, some forms of waste management are covered. Last part of the paper refers to scientific description of the pedestrian bridge made of FRP, which was realized under the Fobridge research grant. The group of researchers headed by professor Chróścielewski from Gdansk University of Technology has developed a design solution of the pedestrian bridge manufactured in one production cycle. Moreover, the footbridge construction contains a significant share of a recyclable material commonly called PET. The article contains main characteristics of the structure and production process based on the resin infusion.

  10. Competition for nitrogen between European beech and sycamore maple shifts in favour of beech with decreasing light availability.

    Science.gov (United States)

    Simon, Judy; Li, Xiuyuan; Rennenberg, Heinz

    2014-01-01

    Plant species use different strategies for maximizing growth and fitness under changing environmental conditions. At the ecosystem level, seedlings in particular compete with other vegetation components for light and nitrogen (N), which often constitute growth-limiting resources. In this study, we investigated the effect of light availability on the competition for N between seedlings of European beech and sycamore maple and analysed the consequences of this competition for the composition of N metabolites in fine roots. Our results show different strategies in N acquisition between beech and sycamore maple. Both species responded to reduced light availability by adapting their morphological and physiological traits with a decrease in biomass and net assimilation rate and an increase in specific leaf area and leaf area ratio. For beech seedlings, competition with sycamore maple led to a reduction in organic N uptake capacity. Reduced light availability led to a decrease in ammonium, but an increase in glutamine-N uptake capacity in sycamore maple. However, this response was stronger compared with that of beech and was accompanied by reduced growth. Thus, our results suggest better adaptation of N acquisition to reduced light availability in beech compared with sycamore maple seedlings.

  11. Favourable outcome of posterior decompression and stabilization in lordosis for cervical spondylotic myelopathy: the spinal cord "back shift" concept.

    Science.gov (United States)

    Denaro, Vincenzo; Longo, Umile Giuseppe; Berton, Alessandra; Salvatore, Giuseppe; Denaro, Luca

    2015-11-01

    Surgical management of patients with multilevel CSM aims to decompress the spinal cord and restore the normal sagittal alignment. The literature lacks of high level evidences about the best surgical approach. Posterior decompression and stabilization in lordosis allows spinal cord back shift, leading to indirect decompression of the anterior spinal cord. The purpose of this study was to investigate the efficacy of posterior decompression and stabilization in lordosis for multilevel CSM. 36 out of 40 patients were clinically assessed at a mean follow-up of 5, 7 years. Outcome measures included EMS, mJOA Score, NDI and SF-12. Patients were asked whether surgery met their expectations and if they would undergo the same surgery again. Bone graft fusion, instrumental failure and cervical curvature were evaluated. Spinal cord back shift was measured and correlation with EMS and mJOA score recovery rate was analyzed. All scores showed a significative improvement (p 0.05). Ninety percent of patients would undergo the same surgery again. There was no deterioration of the cervical alignment, posterior grafted bones had completely fused and there were no instrument failures. The mean spinal cord back shift was 3.9 mm (range 2.5-4.5 mm). EMS and mJOA recovery rates were significantly correlated with the postoperative posterior cord migration (P lordosis is a valuable procedure for patients affected by multilevel CSM, leading to significant clinical improvement thanks to the spinal cord back shift. Postoperative lordotic alignment of the cervical spine is a key factor for successful treatment.

  12. Towards reducing DBP formation potential of drinking water by favouring direct ozone over hydroxyl radical reactions during ozonation.

    Science.gov (United States)

    De Vera, Glen Andrew; Stalter, Daniel; Gernjak, Wolfgang; Weinberg, Howard S; Keller, Jurg; Farré, Maria José

    2015-12-15

    When ozonation is employed in advanced water treatment plants to produce drinking water, dissolved organic matter reacts with ozone (O3) and/or hydroxyl radicals (OH) affecting disinfection byproduct (DBP) formation with subsequently used chlorine-based disinfectants. This study presents the effects of varying exposures of O3 and •OH on DBP concentrations and their associated toxicity generated after subsequent chlorination. DBP formation potential tests and in vitro bioassays were conducted after batch ozonation experiments of coagulated surface water with and without addition of tertiary butanol (t-BuOH, 10 mM) and hydrogen peroxide (H2O2, 1 mg/mg O3), and at different pH (6-8) and transferred ozone doses (0-1 mg/mg TOC). Although ozonation led to a 24-37% decrease in formation of total trihalomethanes, haloacetic acids, haloacetonitriles, and trihaloacetamides, an increase in formation of total trihalonitromethanes, chloral hydrate, and haloketones was observed. This effect however was less pronounced for samples ozonated at conditions favoring molecular ozone (e.g., pH 6 and in the presence of t-BuOH) over •OH reactions (e.g., pH 8 and in the presence of H2O2). Compared to ozonation only, addition of H2O2 consistently enhanced formation of all DBP groups (20-61%) except trihalonitromethanes. This proves that •OH-transformed organic matter is more susceptible to halogen incorporation. Analogously, adsorbable organic halogen (AOX) concentrations increased under conditions that favor •OH reactions. The ratio of unknown to known AOX, however, was greater at conditions that promote direct O3 reactions. Although significant correlation was found between AOX and genotoxicity with the p53 bioassay, toxicity tests using 4 in vitro bioassays showed relatively low absolute differences between various ozonation conditions.

  13. Favourable outcomes of {sup 177}Lu-octreotate peptide receptor chemoradionuclide therapy in patients with FDG-avid neuroendocrine tumours

    Energy Technology Data Exchange (ETDEWEB)

    Kashyap, Raghava [Peter MacCallum Cancer Center, Centre for Cancer Imaging, Melbourne (Australia); Hofman, Michael S.; Kong, Grace; Akhurst, Timothy; Eu, Peter [Peter MacCallum Cancer Center, Centre for Cancer Imaging, Melbourne (Australia); Peter MacCallum Cancer Centre, Neuroendocrine Tumour Service, Melbourne (Australia); Michael, Michael [University of Medicine, Department of Medicine, Melbourne (Australia); Peter MacCallum Cancer Centre, Division of Cancer Medicine, Melbourne (Australia); University of Melbourne, The Sir Peter MacCallum Department of Oncology, Melbourne (Australia); Zannino, Diana [Peter MacCallum Cancer Centre, Biostatistics and Clinical Trials, Melbourne (Australia); Hicks, Rodney J. [Peter MacCallum Cancer Center, Centre for Cancer Imaging, Melbourne (Australia); Peter MacCallum Cancer Centre, Neuroendocrine Tumour Service, Melbourne (Australia); University of Melbourne, The Sir Peter MacCallum Department of Oncology, Melbourne (Australia)

    2014-09-11

    Increased glycolytic activity on FDG PET/CT defines a subgroup of patients with metastatic gastroenteropancreatic neuroendocrine tumour (NET) with a poor prognosis. A limited range of systemic treatment options exist for more aggressive NET. The role of peptide receptor chemoradionuclide therapy (PRCRT) in such patients is, however, unclear. This retrospective study assessed the outcomes of patients with FDG-avid NET treated with PRCRT. Clinical, biochemical and imaging response was assessed after completion of induction treatment of PRCRT with 5-fluorouracil in 52 patients selected for treatment on the basis of somatostatin-receptor imaging without spatially discordant FDG-avid disease. Of the cohort, 67 % had received prior chemotherapy. Overall survival (OS) and progression-free survival (PFS) were also analysed. PRCRT was well tolerated with negligible grade 3/4 toxicities. After a median follow-up period of 36 months, the median OS was not achieved with a median PFS of 48 months. At 3 months after completion of PRCRT 2 % of patients showed a complete anatomical response, 28 % a partial response, 68 % stable disease, and only 2 % progression. On FDG PET/CT, 27 % achieved a complete metabolic response during the follow-up period. A biochemical response (>25 % fall in chromogranin-A levels) was seen in 45 %. PRCRT is an effective treatment in patients with FDG-avid NET, even in patients who have failed conventional therapies. Given apparently higher response rates than with alternative therapeutic options and low toxicity, further research is needed to establish whether PRCRT should be used as a first-line treatment modality in this patient population. (orig.)

  14. Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factor

    Science.gov (United States)

    Smrdel, Uros; Zwitter, Matjaz; Bostjancic, Emanuela; Zupan, Andrej; Kovac, Viljem; Glavac, Damjan; Bokal, Drago; Jerebic, Janja

    2016-01-01

    Abstract Background In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status) do not clearly predict long-term survival. The aim of this case-control study was to evaluate immuno-histochemical and genetic characteristics of the tumour as additional prognostic factors in glioblastoma. Patients and methods Long-term survivor group were 40 patients with glioblastoma with survival longer than 30 months. Control group were 40 patients with shorter survival and matched to the long-term survivor group according to the clinical prognostic factors. All patients underwent multimodality treatment with surgery, postoperative conformal radiotherapy and temozolomide during and after radiotherapy. Biopsy samples were tested for the methylation of MGMT promoter (with methylation specific polymerase chain reaction), IDH1 (with immunohistochemistry), IDH2, CDKN2A and CDKN2B (with multiplex ligation-dependent probe amplification), and 1p and 19q mutations (with fluorescent in situ hybridization). Results Methylation of MGMT promoter was found in 95% and in 36% in the long-term survivor and control groups, respectively (p < 0.001). IDH1 R132H mutated patients had a non-significant lower risk of dying from glioblastoma (p = 0.437), in comparison to patients without this mutation. Other mutations were rare, with no significant difference between the two groups. Conclusions Molecular and genetic testing offers additional prognostic and predictive information for patients with glioblastoma. The most important finding of our analysis is that in the absence of MGMT promoter methylation, longterm survival is very rare. For patients without this mutation, alternative treatments should be explored. PMID:27904447

  15. CLUB-MARTINI: Selecting Favourable Interactions amongst Available Candidates, a Coarse-Grained Simulation Approach to Scoring Docking Decoys.

    Directory of Open Access Journals (Sweden)

    Qingzhen Hou

    Full Text Available Large-scale identification of native binding orientations is crucial for understanding the role of protein-protein interactions in their biological context. Measuring binding free energy is the method of choice to estimate binding strength and reveal the relevance of particular conformations in which proteins interact. In a recent study, we successfully applied coarse-grained molecular dynamics simulations to measure binding free energy for two protein complexes with similar accuracy to full-atomistic simulation, but 500-fold less time consuming. Here, we investigate the efficacy of this approach as a scoring method to identify stable binding conformations from thousands of docking decoys produced by protein docking programs. To test our method, we first applied it to calculate binding free energies of all protein conformations in a CAPRI (Critical Assessment of PRedicted Interactions benchmark dataset, which included over 19000 protein docking solutions for 15 benchmark targets. Based on the binding free energies, we ranked all docking solutions to select the near-native binding modes under the assumption that the native-solutions have lowest binding free energies. In our top 100 ranked structures, for the 'easy' targets that have many near-native conformations, we obtain a strong enrichment of acceptable or better quality structures; for the 'hard' targets without near-native decoys, our method is still able to retain structures which have native binding contacts. Moreover, in our top 10 selections, CLUB-MARTINI shows a comparable performance when compared with other state-of-the-art docking scoring functions. As a proof of concept, CLUB-MARTINI performs remarkably well for many targets and is able to pinpoint near-native binding modes in the top selections. To the best of our knowledge, this is the first time interaction free energy calculated from MD simulations have been used to rank docking solutions at a large scale.

  16. Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation

    DEFF Research Database (Denmark)

    Milman, Nils; Andersen, Claus B.; Hansen, Annette

    2006-01-01

    Blau syndrome is a hereditary granulomatous disease caused by mutations in the CARD15 gene that is diagnosed in children of young age with exanthema/erythema, arthritis/periarthritis and/or uveitis. We report two cases of Blau syndrome in Danish Caucasian monozygotic male twins, exhibiting...... a heterozygous de novo R334W mutation in codon 334 of CARD15. The patients were initially diagnosed as having sarcoidosis. In both twins, symptoms (exanthema, arthritis/periarthritis) started at 1 year of age, and were followed by uveitis at 7-10 years of age. There was no involvement of the lungs or other...... quality of life. At follow up at 20 years of age (after 2-5 years of infliximab treatment) the twins had an almost normal physical appearance and a normal psychomotoric development, indicating a favourable short-term prognosis of the disease. Blau syndrome has pathologic, clinical and therapeutic features...

  17. Pattern of hospitalized-stroke patients in ASEAN countries an ASNA stroke epidemiological study

    Directory of Open Access Journals (Sweden)

    Jusuf Misbach

    2001-03-01

    Full Text Available To better understanding the demographic characteristics, admission time, clinical pattern, risk factors, stroke type, length of stay, and discharge outcome of hospitalized acute stroke patients in ASEAN member countries, ASEAN   Neurological Association (ASNA formed a Standing Commiltee for Stroke in 1996 and this is the first ASNA Stroke Epidemiological Study using the same stroke protocol. This prospective hospital based study was conducted in seven ASEAN countries (Brunei, Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam by participating neurologists from October 1996 to March 1997. Of the 3723 consecutive hospitalized stroke patients (2030 males and 1660 females from 44 participating hospitals in this study ie Brunei (n=53, Indonesia (n=2065, Malaysia (n=300,Philippines (n=545,Singapore (n=232, Thailand (n=244 and Vietnam (n=284, the mean age was 59.0 ± 13,8 years 16% of patients were younger than 45 years and 37% of patients were older than 65 years. There were no significant differences in age at onset among stroke subjects except in Vietnam (younger and Singapore (older. The sex distribution showed a slight higher prevalence of women in Singapore and in the age group > 64 years. The mean adrnission time was 41.5 ± 87.0 hours, 19% of patients were admitted within 3 hours, 29% within 6 hours and 66% more than 6 hours (delayed admission especially in Malaysia and Singapore (80% and 77% respectively. Motor disability was the most prevalent clinical feature in all countries and carotid bruit was the rarest (1%. Hypertension was the most common risk factor (68% in all countries, followed by TIA (35%, smoking, diabetes mellitus, ischnemic heart disease and hypercholesterolemia. CT scan was performed on 76% of subjects. The diagnostic classification was non lacunar anterior circulation (32%, lacunar infarction (14%, hemorrhagic stroke (26%, SAH (4%. Mean length of stay was 11.4 ± 11.8 days. Most of the patients

  18. Agglutinating mouse IgG3 compares favourably with IgMs in typing of the blood group B antigen: Functionality and stability studies.

    Science.gov (United States)

    Klaus, Tomasz; Bzowska, Monika; Kulesza, Małgorzata; Kabat, Agnieszka Martyna; Jemioła-Rzemińska, Małgorzata; Czaplicki, Dominik; Makuch, Krzysztof; Jucha, Jarosław; Karabasz, Alicja; Bereta, Joanna

    2016-08-03

    Mouse immunoglobulins M (IgMs) that recognize human blood group antigens induce haemagglutination and are used worldwide for diagnostic blood typing. Contrary to the current belief that IgGs are too small to simultaneously bind antigens on two different erythrocytes, we obtained agglutinating mouse IgG3 that recognized antigen B of the human ABO blood group system. Mouse IgG3 is an intriguing isotype that has the ability to form Fc-dependent oligomers. However, F(ab')2 fragments of the IgG3 were sufficient to agglutinate type B red blood cells; therefore, IgG3-triggered agglutination did not require oligomerization. Molecular modelling indicated that mouse IgG3 has a larger range of Fab arms than other mouse IgG subclasses and that the unique properties of mouse IgG3 are likely due to the structure of its hinge region. With a focus on applications in diagnostics, we compared the stability of IgG3 and two IgMs in formulated blood typing reagents using an accelerated storage approach and differential scanning calorimetry. IgG3 was much more stable than IgMs. Interestingly, the rapid decrease in IgM activity was caused by aggregation of the molecules and a previously unknown posttranslational proteolytic processing of the μ heavy chain. Our data point to mouse IgG3 as a potent diagnostic tool.

  19. Agglutinating mouse IgG3 compares favourably with IgMs in typing of the blood group B antigen: Functionality and stability studies

    Science.gov (United States)

    Klaus, Tomasz; Bzowska, Monika; Kulesza, Małgorzata; Kabat, Agnieszka Martyna; Jemioła-Rzemińska, Małgorzata; Czaplicki, Dominik; Makuch, Krzysztof; Jucha, Jarosław; Karabasz, Alicja; Bereta, Joanna

    2016-01-01

    Mouse immunoglobulins M (IgMs) that recognize human blood group antigens induce haemagglutination and are used worldwide for diagnostic blood typing. Contrary to the current belief that IgGs are too small to simultaneously bind antigens on two different erythrocytes, we obtained agglutinating mouse IgG3 that recognized antigen B of the human ABO blood group system. Mouse IgG3 is an intriguing isotype that has the ability to form Fc-dependent oligomers. However, F(ab′)2 fragments of the IgG3 were sufficient to agglutinate type B red blood cells; therefore, IgG3-triggered agglutination did not require oligomerization. Molecular modelling indicated that mouse IgG3 has a larger range of Fab arms than other mouse IgG subclasses and that the unique properties of mouse IgG3 are likely due to the structure of its hinge region. With a focus on applications in diagnostics, we compared the stability of IgG3 and two IgMs in formulated blood typing reagents using an accelerated storage approach and differential scanning calorimetry. IgG3 was much more stable than IgMs. Interestingly, the rapid decrease in IgM activity was caused by aggregation of the molecules and a previously unknown posttranslational proteolytic processing of the μ heavy chain. Our data point to mouse IgG3 as a potent diagnostic tool. PMID:27484487

  20. Phylogenetic studies favour the unification of Pennisetum, Cenchrus and Odontelytrum (Poaceae): a combined nuclear, plastid and morphological analysis, and nomenclatural combinations in Cenchrus.

    Science.gov (United States)

    Chemisquy, M Amelia; Giussani, Liliana M; Scataglini, María A; Kellogg, Elizabeth A; Morrone, Osvaldo

    2010-07-01

    Twenty-five genera having sterile inflorescence branches were recognized as the bristle clade within the x = 9 Paniceae (Panicoideae). Within the bristle clade, taxonomic circumscription of Cenchrus (20-25 species), Pennisetum (80-140) and the monotypic Odontelytrum is still unclear. Several criteria have been applied to characterize Cenchrus and Pennisetum, but none of these has proved satisfactory as the diagnostic characters, such as fusion of bristles in the inflorescences, show continuous variation. A phylogenetic analysis based on morphological, plastid (trnL-F, ndhF) and nuclear (knotted) data is presented for a representative species sampling of the genera. All analyses were conducted under parsimony, using heuristic searches with TBR branch swapping. Branch support was assessed with parsimony jackknifing. Based on plastid and morphological data, Pennisetum, Cenchrus and Odontelytrum were supported as a monophyletic group: the PCO clade. Only one section of Pennisetum (Brevivalvula) was supported as monophyletic. The position of P. lanatum differed among data partitions, although the combined plastid and morphology and nuclear analyses showed this species to be a member of the PCO clade. The basic chromosome number x = 9 was found to be plesiomorphic, and x = 5, 7, 8, 10 and 17 were derived states. The nuclear phylogenetic analysis revealed a reticulate pattern of relationships among Pennisetum and Cenchrus, suggesting that there are at least three different genomes. Because apomixis can be transferred among species through hybridization, its history most likely reflects crossing relationships, rather than multiple independent appearances. Due to the consistency between the present results and different phylogenetic hypotheses (including morphological, developmental and multilocus approaches), and the high support found for the PCO clade, also including the type species of the three genera, we propose unification of Pennisetum, Cenchrus and Odontelytrum. Species of Pennisetum and Odontelytrum are here transferred into Cenchrus, which has priority. Sixty-six new combinations are made here.

  1. A case of Silver–Russell syndrome (SRS): multiple pituitary hormone deficiency, lack of H19 hypomethylation and favourable growth hormone (GH) treatment response

    Indian Academy of Sciences (India)

    Zoran S. Gucev; Velibor Tasic; Aleksandra Jancevska; Ilija Kirovski

    2009-08-01

    Hypomethylation of the imprinting control region 1 (ICR1) at the IGF2/H19 locus on 11p15 is linked to Silver–Russell syndrome (SRS) and/or hemihypertrophy. This SRS patient was born in term with weight of 3500 g (50 percentile) and length 48 cm (>1 SD below the mean). He was first noticed at the age of 10 years for short stature (114.5 cm, $-3.85$ SD), relatively normal head circumference, a classic facial phenotype, hemihypertrophy (2.5 cm thinner left arm and leg in comparison to the right, asymmetric face), moderate clinodactyly and striking thinness (BMI of 15.3). At the age of 30, the body asymmetry ameliorated (1 cm thinner left arm and leg than the right), and BMI normalized (20.5 cm). Methylation analysis was performed by bisulphate treatment of DNA samples, radiolabelled PCR amplification, and digestion of the PCR products using restriction enzymes. The patient had normomethylation, and in addition hypopituitarism, with low levels of growth hormone (GH) (provocative testing before the start and after termination of GH treatment), thyroxin, TSH, FSH, LH and testosterone. The GH was given for six years, growth response was satisfactory and he reached an adult height of 166 cm. This is a first report of hypopituitarism in a patient with SRS without H19 hypomethylation. It seems that the lack of hypomethylation in this hypopituitary SRS patient is responsible, at least partly, for the favourable final adult height under GH treatment.

  2. Favourable Formations for CO{sub 2} Storage in the Almazan Basin; Formaciones Favorables para el Almacenamiento de CO{sub 2} en la Cuenca de Almazan

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Rivas, C.; Lomba Falcon, L.

    2008-04-10

    Geological storage of carbon dioxide is one of the technological options that have been considered nowadays for global climate change mitigation. Underground CO{sub 2} storage requires the selection and identification of deep geological formations which must meet criteria for health and environmental safety in the middle-term of one thousand years. Deep permeable formations, depleted oil and gas fields, unminable coal seams and saline rocks are possible geological formations for CO{sub 2} storage. Some areas in our country have been selected to search potential CO{sub 2} reservoirs. Among these areas, sedimentary basins are highlighted because of their thick stratigraphic sequences and the availability of extensive geological data which are coming from fossil fuel exploration. In this report, the identification and selection of favourable geological formations in the Almazan basin is presented. A 3D simplified subsurface basin geological model that was based on a Geographic Information System is included as well. The report also includes suitable CO{sub 2} injection areas in the surface for the selected geological formations. Finally, a preliminary CO{sub 2} storage capacity estimation of a potential structural trap has been calculated, considering only physical CO{sub 2} trapping. This work has been undertaken in the framework of the Geological CO{sub 2} Storage Project which is within the Singular Strategic Project of the Ministry of Education and Science Generation, Capture and Storage advanced technologies of CO{sub 2}. (Author) 84 refs.

  3. Prey type and foraging ecology of Sanderlings Calidris alba in different climate zones: are tropical areas more favourable than temperate sites?

    Directory of Open Access Journals (Sweden)

    Kirsten Grond

    2015-08-01

    Full Text Available Sanderlings (Calidris alba are long-distance migratory shorebirds with a non-breeding range that spans temperate and tropical coastal habitats. Breeding in the High Arctic combined with non-breeding seasons in the tropics necessitate long migrations, which are energetically demanding. On an annual basis, the higher energy expenditures during migration might pay off if food availability in the tropics is higher than at temperate latitudes. We compared foraging behaviour of birds at a north temperate and a tropical non-breeding site in the Netherlands and Ghana, respectively. In both cases the birds used similar habitats (open beaches, and experienced similar periods of daylight, which enabled us to compare food abundance and availability, and behavioural time budgets and food intake. During the non-breeding season, Sanderlings in the Netherlands spent 79% of their day foraging; in Ghana birds spent only 38% of the daytime period foraging and the largest proportion of their time resting (58%. The main prey item in the Netherlands was the soft-bodied polychaete Scolelepis squamata, while Sanderlings in Ghana fed almost exclusively on the bivalve Donax pulchellus, which they swallowed whole and crushed internally. Average availability of polychaete worms in the Netherlands was 7.4 g ash free dry mass (AFDM m−2, which was one tenth of the 77.1 g AFDM m−2 estimated for the beach in Ghana. In the tropical environment of Ghana the Sanderlings combined relatively low energy requirements with high prey intake rates (1.64 mg opposed to 0.13 mg AFDM s−1 for Ghana and the Netherlands respectively. Although this may suggest that the Ghana beaches are the most favourable environment, processing the hard-shelled bivalve (D. pulchellus which is the staple food could be costly. The large amount of daytime spent resting in Ghana may be indicative of the time needed to process the shell fragments, rather than indicate rest.

  4. No favourable effects of Cr (III supplementation on lipid metabolism on type 2 Diabetes Mellitus: a meta-analysis of single and double-blind, randomized, placebo controlled trials.

    Directory of Open Access Journals (Sweden)

    Ismael San Mauro Martín

    2017-03-01

    Full Text Available Introduction. Type 2 diabetes mellitus is an important global health issue which prevalence has been increasing in the last years. Many studies have linked chromium supplementation with improvement of type 2 diabetes mellitus. Aim. Perform a meta-analysis of single and double-blind, randomized, placebo controlled trials, where participants diagnosed of type 2 DM or glucose intolerants were supplemented with Cr (III. Methods. Systematic literature search in electronic databases was conducted, using the following search terms: (diabetes AND (chromium, until July, 2016. Eligible studies were limited to double or single-blind, parallel group, placebo-controlled, randomized clinical trials, comparing Cr mono or combined supplementation at least for 30 days against placebo, in subjects diagnosed of type 2 DM or with glucose intolerance. Results. Total doses of Cr supplementation and brewer’s yeast ranged from 20 to 1000 µg/day, and duration of supplementation ranged from 30 to 120 days. No statistically significant reduction was found in HDL-C (p=0.63, LDL-C (p=0.53 and TG (p=0.34 compared to placebo; with a weighted average effect size of -0.44 (95% CI: -2.2 to 1.33 mg/dL, -1.43 (95% CI: -5.94 to 3.08 mg/dL and -7.43 (95% CI: -22.67 to 7.82 mg/dL, respectively. Conclusion. Evidence in our study suggests no favourable effects of chromium supplementation on lipid metabolism control in patients with type 2 diabetes.

  5. Analisis Penerapan Value Creation Selling dalam Strategi Pemasaran Perusahaan Jasa Logistik: Studi Kasus di PT XYZ

    Directory of Open Access Journals (Sweden)

    Darjat Sudrajat

    2012-05-01

    Full Text Available A company is a market-oriented when the culture of value creation superior customer systematically and comprehensively implemented on company concerned. Value can be defined as the ratio of benefit to cost, where customers expect a rate of return equal or exceed the costs they incurred to obtain the products they bought. From the case studies conducted on PT XYZ, then, in getting the project tender delivery of goods geophysical equipment for the Brunei Loon project, it has been implemented value selling creation, which includes three main components, ie customer portraits, the proposed value, and benefits to customers or total value of ownership. Overall, the efficiency given value is about 20% compared to its closest competitor, the safety shipping and on time, as well as the positive benefits of the profit margin, cash flow, return on investment, brand equity, market share and customers.

  6. Is the Current Royal Australian Air Force an Air Force of Strategic Influence?

    Science.gov (United States)

    2015-02-17

    global non-state threats including terrorism, extremism, weapons proliferation, transnational crime, illegal immigration, and illegal fishing as...export markets in Asia with favourable balances of trade, and perhaps most importantly, experienced exceptionally favourable exchange rate with the US...in, and regularly hosts, bilateral and multilateral exercises with the US, and a number of SEA nations including Brunei, Indonesia , Malaysia

  7. Underground CO{sub 2} Storage: Approach for Favourable Formations in Ebro Basin; AGP de CO{sub 2}: Seleccion de Formaciones Favorables en la Cuenca del Ebro

    Energy Technology Data Exchange (ETDEWEB)

    Campos, R.; Perucha, A.; Recreo, F.

    2008-04-10

    The study of the possibilities of conducting Deep Geological CO{sub 2} Storage inside Spanish territory is being performed through the Strategic Singular Project PS-120000-2005-2 of the National Program of Energy from the Education and Science Ministry, and called CO{sub 2} generation, sequestration and storage advanced technologies, sub project N3 CO{sub 2} Geological Storage This report studies the possibilities the Ebro basin offers for definitive CO{sub 2} storage as one of the Spanish selected areas from previous studies. The study and reinterpretation of the information obtained from the hydrocarbon exploration accomplished in the area has lead to the selection of a series of geological formations. These formations have been chosen attending certain characteristics such as their disposition, extension, depth and porosity. The study has also been conducted considering the characteristics of the geological formations above the CO{sub 2} storage formations so as to guarantee the sealing of the storage. The study includes the approximate estimation of the storage capacity for each of the formations in Megatons of CO{sub 2}, which can be useful in future decision making. Deep geological storage is one of the more relevant international initiatives in order to eliminate or reduce the anthropogenic CO{sub 2} emissions to the atmosphere. (Author) 68 refs.

  8. The environmental policies which favour the renewable energies development; Les politiques environnementales d'incitation au developpement des energies renouvelables

    Energy Technology Data Exchange (ETDEWEB)

    Menanteau, Ph.; Finon, D.; Lamy, M.L.

    2001-05-01

    Facing the climatic changes and the Europe policy of the renewable energies development, the authors wonder on the compared efficiency of the incentive tools. The study is theoretical with the presentation of the price and the quantity approaches, but also practical with concrete examples. It reveals the theoretical qualities of the green certificate approach. (A.L.B.)

  9. Cumulative live birth rates following lVF in 41-to 43-year-old women presenting with favourable ovarian reserve characteristics

    NARCIS (Netherlands)

    van Disseldorp, J.; Eijkemans, M. J. C.; Klinkert, E. R.; Velde, E. R. te; Fauser, B. C.; Broekmans, F. J. M.

    For women aged 41-43 years old, success rates in IVF are generally poor. This study aimed to assess cumulative live birth rate related to treatment costs over a maximum of three IVF cycles in selected women who were considered to still have adequate ovarian reserve. Fifty-five patients (38% of the

  10. Mesenchymal stem cells favour healing of the cutaneous radiation syndrome; Les cellules souches mesenchymateuses favorisent la cicatrisation des lesions cutanees radio induites

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S.; Mouiseddine, M.; Mathieu, N.; Semont, A.; Monti, P.; Dudoignon, N.; Sache, A.; Boutarfa, A.; Thierry, D.; Voisin, P.; Gourmelon, P.; Chapel, A. [IRSN, Dir. de radioprotection de l' Homme, 92 - Fontenay-aux-Roses (France)

    2006-10-15

    It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immuno-deficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a {sup 60} Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immuno-histology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy. (authors)

  11. The small breathing amplitude at the upper lobes favours the attraction of polymorphonuclear neutrophils to Mycobacterium tuberculosis lesions and helps to understand the evolution towards active disease in an individual-based model

    Directory of Open Access Journals (Sweden)

    Pere-Joan eCardona

    2016-03-01

    Full Text Available Infection with Mycobacterium tuberculosis (Mtb can induce two kinds of lesions, namely proliferative and exudative. The former are based on the presence of macrophages with controlled induction of intragranulomatous necrosis, and are even able to stop its physical progression, thus avoiding the induction of active tuberculosis (TB. In contrast, the most significant characteristic of exudative lesions is their massive infiltration with polymorphonuclear neutrophils (PMNs, which favour enlargement of the lesions and extracellular growth of the bacilli. We have built an individual-based model (IBM (known as TBPATCH using the NetLogo interface to better understand the progression from Mtb infection to TB. We have tested four main factors previously identified as being able to favour the infiltration of Mtb-infected lesions with PMNs, namely the tolerability of infected macrophages to the bacillary load; the capacity to modulate the Th17 response; the breathing amplitude (large or small in the lower and upper lobes respectively, which influences bacillary drainage at the alveoli; and the encapsulation of Mtb-infected lesions by the interlobular septae that structure the pulmonary parenchyma into secondary lobes. Overall, although all the factors analysed play some role, the small breathing amplitude is the major factor determining whether Mtb-infected lesions become exudative, and thus induce TB, thereby helping to understand why this usually takes place in the upper lobes. This information will be very useful for the design of future prophylactic and therapeutic approaches against TB.

  12. The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs.

    Science.gov (United States)

    Löscher, Wolfgang; Hoffmann, Katrin; Twele, Friederike; Potschka, Heidrun; Töllner, Kathrin

    2013-11-01

    Recently, the imidazolinone derivative imepitoin has been approved for treatment of canine epilepsy. Imepitoin acts as a low-affinity partial agonist at the benzodiazepine (BZD) site of the GABAA receptor and is the first compound with such mechanism that has been developed as an antiepileptic drug (AED). This mechanism offers several advantages compared to full agonists, including less severe adverse effects and a lack of tolerance and dependence liability, which has been demonstrated in rodents, dogs, and nonhuman primates. In clinical trials in epileptic dogs, imepitoin was shown to be an effective and safe AED. Recently, seizures in dogs have been proposed as a translational platform for human therapeutic trials on new epilepsy treatments. In the present study, we compared the anticonvulsant efficacy of imepitoin, phenobarbital and the high-affinity partial BZD agonist abecarnil in the timed i.v. pentylenetetrazole (PTZ) seizure threshold test in dogs and, for comparison, in mice. Furthermore, adverse effects of treatments were compared in both species. All drugs dose-dependently increased the PTZ threshold in both species, but anticonvulsant efficacy was higher in dogs than mice. At the doses selected for this study, imepitoin was slightly less potent than phenobarbital in increasing seizure threshold, but markedly more tolerable in both species. Effective doses of imepitoin in the PTZ seizure model were in the same range as those suppressing spontaneous recurrent seizures in epileptic dogs. The study demonstrates that low-affinity partial agonists at the benzodiazepine site of the GABAA receptor, such as imepitoin, offer advantages as a new category of AEDs.

  13. Has the implementation of the TRIPS Agreement in Latin America and the Caribbean produced intellectual property legislation that favours public health?

    Science.gov (United States)

    Oliveira, Maria Auxiliadora; Bermudez, Jorge Antonio Zepeda; Chaves, Gabriela Costa; Velásquez, Germán

    2004-01-01

    OBJECTIVE: The World Trade Organization's Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement establishes minimum standards for intellectual property rights, including patent protection for pharmaceuticals; therefore, it may make it difficult for developing countries to gain access to medicines, especially those countries that are the least developed. This study aims to determine whether implementation of the TRIPS Agreement in Latin American and Caribbean countries has generated patent legislation that is sensitive to public health needs. METHODS: Legislation in 11 Latin American and Caribbean countries was analysed. The variables considered in the analysis were: the term of patents issued, patentable subject matter, transition periods (that is, time until legislation was enacted), reversal of the burden of proof of patent infringement, exhaustion of rights, compulsory licensing and the early working exception (which allows a country to complete all procedures necessary to register a generic product before the original patent expires). FINDINGS: By 2000, all of the countries studied had reformed their legislation to conform to the agreement. Brazil and Argentina used the transition period until 2005 to grant patents in the pharmaceutical industry. All countries, except Panama, made use of the safeguards and flexibilities available through the agreement by including mechanisms for compulsory licensing in their legislation. Argentina; Bolivia, Colombia, Ecuador, Peru and Venezuela (countries that represented the Andean community); the Dominican Republic; and Panama included mechanisms to allow parallel importation. Mexico did not. Brazil only permits parallel importation after a compulsory licence has been issued. The early working exception is included in legislation in Brazil and the Dominican Republic. CONCLUSION: The countries in this study did not incorporate all of the mechanisms allowed for by the Agreement and are not adequately using the

  14. Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties.

    Science.gov (United States)

    Humphreys, W G; Obermeier, M T; Barrish, J C; Chong, S; Marino, A M; Murugesan, N; Wang-Iverson, D; Morrison, R A

    2003-11-01

    1. Based on binding affinity, 2'-amino-N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1,1'-biphenyl]-2-sulfonamide (2) was identified as an initial lead in a programme to identify selective endothelin (ET) receptor antagonists. However, the compound was extensively metabolized in preclinical animal species and human in vitro systems due to oxidative biotransformation. 2. To optimize this structural class, the site of metabolism of 2 was determined. This allowed for focussed structure-activity and structure-metabolism studies aimed at finding more metabolically stable analogues that maintained potency. New analogues were screened for their ET binding characteristics and their stability in rat and human liver microsomes. 3. The use of the microsomal stability screen was tested by the determination of the pharmacokinetic parameters of select analogues. A good correlation was found between reduced rates of rat microsomal metabolism and reduced clearance in the rat. 4. N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide (3) was identified as an analogue with improved in vitro properties and further studies revealed that the compound had improved pharmacokinetic properties. 5. N-[[2'-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]acetamide (4) was subsequently identified as a compound with superior in vitro properties compared with compound 3, but when tested in vivo it had a substantially increased rate of clearance. Further studies demonstrated that the clearance of this closely related structural analogue was not dictated by metabolic processes, but was mediated by transport-mediated direct biliary excretion. 6. The utility of screening for in vitro liver microsomal stability as part of the lead optimization process for compounds with metabolic liabilities was shown. It was also shown that relatively small molecular changes can dramatically change the disposition of closely related analogues and care

  15. Stratified ventilation: Fresh air from below more favourable also in hospitals. Part 2; Schichtlueftung: Frische Luft kommt auch im Krankenhaus besser von unten. T. 2

    Energy Technology Data Exchange (ETDEWEB)

    Kochendoerfer, C. [Stuttgart Univ. (Germany). Lehrstuhl fuer Heiz- und Raumlufttechnik

    1999-06-01

    The contribution presents the considerations, experimental studies and practical experience with regard to the new building of Olgahospital, Stuttgart (intensive care ward for premature babies). The project was carried out under the leadership of Stuttgart central construction office in cooperation with the Department of Heating and Air Conditioning Engineering of Stuttgart University. [Deutsch] In den folgenden Ausfuehrungen sollen die Ueberlegungen, experimentellen Voruntersuchungen sowie die praktischen Erfahrungen zum Erweiterungsbau der Neoantologie 1 (Intensivpflegestation fuer Fruehgeburten) des Olgahospitals in Stuttgart vorgestellt werden. Das Projekt wurde unter der Fuehrung des Hochbauamtes der Landeshauptstadt Stuttgart in Zusammenarbeit mit dem Lehrstuhl fuer Heiz- und Raumlufttechnik der Universitaet Stuttgart durchgefuehrt. (orig.)

  16. Recurrent nocturnal hypoglycaemia as a cause of morning fatigue in treated Addison's disease--favourable response to dietary management: a case report.

    Science.gov (United States)

    Petersen, Kristina S; Rushworth, R Louise; Clifton, Peter M; Torpy, David J

    2015-10-24

    Addison's disease, or primary adrenal insufficiency, is often associated with reduced well-being and fatigue despite use of currently recommended adrenal hormone replacement. Hypoglycaemia is a known manifestation of glucocorticoid deficiency, but is generally considered rare in adults and not relevant to troubling ongoing symptoms in patients with Addison's disease. A 43 year old woman with a three year history of Addison's disease complained of severe morning fatigue and headaches, despite standard glucocorticoid replacement therapy in the form of thrice daily hydrocortisone and mineralocorticoid replacement with fludrocortisone. Alternative glucocorticoid replacement regimens and the addition of dehydroepiandrosterone replacement therapy had no effect. Nocturnal hypoglycaemia was suspected and a 4-day continuous glucose monitor system (CGMS) revealed hypoglycaemia (interstitial glucose Addison's disease is unknown, but it may be that investigation for hypoglycaemia and treatment, where necessary, could assist some sufferers to achieve improved wellbeing. A systematic study of this phenomenon in Addison's disease is required.

  17. Suicide by antidepressant intoxication identified at autopsy in Vienna from 1991-1997: the favourable consequences of the increasing use of SSRIs.

    Science.gov (United States)

    Frey, R; Schreinzer, D; Stimpfl, T; Vycudilik, W; Berzlanovich, A; Kasper, S

    2000-03-01

    In the area of Vienna, any person dying under questionable circumstances is examined at the Institute of Forensic Medicine, where the cause of death is determined by means of autopsy and chemical analysis. Our study on fatal intoxications was performed in the period between 1991 and 1997, when selective serotonin reuptake inhibitors (SSRIs) were establishing themselves on the market, reaching the top of prescription statistics. Tricyclic antidepressants (TCAs) were involved in 30 single- and 127 multiple-substance intoxications, with amitriptyline and doxepin being the most frequently used drugs. SSRIs were involved in five multiple-substance intoxications. The f-value, which refers to the number of deaths per million defined daily doses prescribed, was found to be significantly (Pantidepressants declined significantly (Pantidepressants did not coincide with an increased number of deaths caused by these drugs.

  18. Role of self-sufficiency, productivity and diversification on the economic sustainability of farming systems with autochthonous sheep breeds in less favoured areas in Southern Europe.

    Science.gov (United States)

    Ripoll-Bosch, R; Joy, M; Bernués, A

    2014-08-01

    Traditional mixed livestock cereal- and pasture-based sheep farming systems in Europe are threatened by intensification and specialisation processes. However, the intensification process does not always yield improved economic results or efficiency. This study involved a group of farmers that raised an autochthonous sheep breed (Ojinegra de Teruel) in an unfavourable area of North-East Spain. This study aimed to typify the farms and elucidate the existing links between economic performance and certain sustainability indicators (i.e. productivity, self-sufficiency and diversification). Information was obtained through direct interviews with 30 farms (73% of the farmers belonging to the breeders association). Interviews were conducted in 2009 and involved 32 indicators regarding farm structure, management and economic performance. With a principal component analysis, three factors were obtained explaining 77.9% of the original variance. This factors were named as inputs/self-sufficiency, which included the use of on-farm feeds, the amount of variable costs per ewe and economic performance; productivity, which included lamb productivity and economic autonomy; and productive orientation, which included the degree of specialisation in production. A cluster analysis identified the following four groups of farms: high-input intensive system; low-input self-sufficient system; specialised livestock system; and diversified crops-livestock system. In conclusion, despite the large variability between and within groups, the following factors that explain the economic profitability of farms were identified: (i) high feed self-sufficiency and low variable costs enhance the economic performance (per labour unit) of the farms; (ii) animal productivity reduces subsidy dependence, but does not necessarily imply better economic performance; and (iii) diversity of production enhances farm flexibility, but is not related to economic performance.

  19. Low temperature and dust favour in vitro survival of Mycoplasma hyopneumoniae: time to revisit indirect transmission in pig housing.

    Science.gov (United States)

    Browne, C; Loeffler, A; Holt, H R; Chang, Y M; Lloyd, D H; Nevel, A

    2017-01-01

    Porcine enzootic pneumonia (EP) caused by Mycoplasma hyopneumoniae adversely affects pig welfare and is associated with major economic losses in the pig industry worldwide. Transmission is predominantly by direct contact, but the role of indirect transmission remains poorly understood. This study examined survival of six M. hyopneumoniae isolates dried onto five different surfaces encountered in pig units and exposed to temperatures of 4, 25 and 37°C for up to 12 days. Survival of the organisms was determined by recovering the organism from the surface material and culturing in Friis broth. Data were analysed by logistic regression to identify factors influencing survival of M. hyopneumoniae. Maximum survival was 8 days for all isolates on at least one surface (except stainless steel) at 4°C and was limited to 2 days at 25 and 37°C. Overall, dust and polypropylene copolymer supported M. hyopneumoniae survival the longest when compared with other surface materials. In conclusion, we have demonstrated that M. hyopneumoniae can survive outside the host for at least 8 days. Understanding the transmission of Mycoplasma hyopneumoniae and optimizing biosecurity practices are keys to reducing the use of antimicrobial agents to control this pathogen. Direct transmission of the pathogen between pigs is the main route of spread and its lack of cell wall may compromise its resilience outside the host. The results from our study show that M. hyopneumoniae can survive for up to several days on dry surfaces and therefore may have the potential to infect pigs by indirect transmission. Factors influencing the survival of M. hyopneumoniae outside the host are further elucidated. © 2016 The Society for Applied Microbiology.

  20. The Most Favourable Procedure for the Isolation of Cell-Free DNA from the Plasma of Iso-Immunized RHD-Negative Pregnant Women

    Directory of Open Access Journals (Sweden)

    Riyaz Ahmad Rather

    2015-12-01

    Full Text Available Background: The ability to achieve quality recovery of cell-free foetal DNA is important for making non-invasive prenatal diagnoses. In this study, we performed quantitative and qualitative analyses of isolated DNA from maternal plasma, using different DNA-isolation methods. Method: DNA was isolated from 30 iso-immunized women via the QIAamp column-based method, using four different elution volumes and two conventionally based methods. Real-time polymerase chain-reaction quantification of RHD and β-globin genes was performed in order to determine foetal-specific sequences and total genome equivalents, respectively. Results: The column-based method at a 3 μl elution volume yielded the highest quality and quantity of total DNA (67.0±0.6 ng/μL. At a 3 μl elution volume, the β-globin and RHD ‐gene sequences were estimated to be the highest among all isolation procedures, with 2778.13±1.5 and 66.9±0.6 GEq/mL, respectively, and a 100% sensitivity for RHD ‐gene sequence detection. Among the two conventional manual methods, the boiling lysis method yielded a higher DNA concentration (53.8±0.8 ng/μL and purity (1.73±0.05. In addition, the method's sensitivity for foetal-detection sequences was only 80%, whereas the salting-out method's sensitivity was just 70%. Conclusions: This study confirms the theory that the QIAamp method is a specific and sensitive approach for purifying and quantifying plasma DNA, when used in the minimum elution volume.

  1. Survey on nurses' demand of online learning and favoured teaching patterns%护理人员对网络学习及教学模式的需求调查

    Institute of Scientific and Technical Information of China (English)

    田京京; 张立力; 纪翠红; 时光

    2011-01-01

    Objective To comprehend nurses' demand of online learning and the teaching patterns they favoured,and to establish optimal online teaching model for nurses. Methods A total of 474 students on adult nursing education program were surveyed by random sampling methods. Results Among 455 nurses who had been participating in the E-learning of nursing courses, 73.4% had been learning online regularly; 252 nurses (55.4%) were interested in online learning; 218 nurses (47.9%) studied more than an hour per day online;80.9% (368 nurses) admitted that online learning had good effect; 64.8% demanded of situational teaching model,which ranked in the first place, and 49.7% demanded of collaborative teaching model, which came in last. Conclusion Online teaching of nursing courses can basically meet the learning needs of nurses. Web-based scene teaching model is needed to be extended.Nurses' understanding of collaborative teaching model should be further improved so as to make the existing online teaching of nursing courses produce better effect.%目的 了解护理人员对护理课程网络学习及网络教学模式的需求情况,建立符合护理人员特点的最佳网络教学模式. 方法 采用随机抽样的方法对474名护理成教生进行问卷调查. 结果 参加过护理课程网络学习的455人中,73.4%的护士经常上网学习;对网络学习感兴趣者252人(55.4%);学习时间>1 h/d者218人(47.9%);80.9%(368人)的护士认可护理课程网络教学的效果;护士对情景式教学模式的需求排在第一位(64.8%),对协作式教学模式的需求排在最后一位(49.7%). 结论 已开设的护理课程网络教学基本能满足护理人员的学习需求.护理课程的网络教学需推广情景式教学模式,进一步提高护理人员对协作式教学模式的认识,可望有效改善现行护理课程的网络教学质量.

  2. Favourable uranium-phosphate exploration trends guided by the application of statistical factor analysis technique on the aerial gamma spectrometric data in Syrian desert (Area-1), Syria

    Science.gov (United States)

    Asfahani, J.; Al-Hent, R.; Aissa, M.

    2016-02-01

    A scored lithological map including 10 radiometric units is established through applying factor analysis approach to aerial spectrometric data of Area-1, Syrian desert, which includes Ur, eU, eTh, K%, eU/eTh, eU/K%, and eTh/K%. A model of four rotated factors F1, F2, F3, and F4 is adapted for representing 234,829 data measured points in Area-1, where 86% of total data variance is interpreted. A geological scored pseudo-section derived from the lithological scored map is established and analyzed in order to show the possible stratigraphic and structural traps for uranium occurrences associated with phosphate deposits in the studied Area-1. These identified traps presented in this paper need detailed investigation and must be necessarily followed and checked by ground validations and subsurface well logging, in order to locate the anomalous uranium occurrences and explore with more confidence and certitude their characteristics as a function of depth.

  3. Favourable uranium–phosphate exploration trends guided by the application of statistical factor analysis technique on the aerial gamma spectrometric data in Syrian desert (Area-1), Syria

    Indian Academy of Sciences (India)

    J Asfahani; R Al-Hent; M Aissa

    2016-02-01

    A scored lithological map including 10 radiometric units is established through applying factor analysis approach to aerial spectrometric data of Area-1, Syrian desert, which includes Ur, eU, eTh, K%, eU/eTh, eU/K%, and eTh/K%. A model of four rotated factors F1, F2, F3, and F4 is adapted for representing 234,829 data measured points in Area-1, where 86% of total data variance is interpreted. A geological scored pseudo-section derived from the lithological scored map is established and analyzed in order to show the possible stratigraphic and structural traps for uranium occurrences associated with phosphate deposits in the studied Area-1. These identified traps presented in this paper need detailed investigation and must be necessarily followed and checked by ground validations and subsurface well logging, in order to locate the anomalous uranium occurrences and explore with more confidence and certitude their characteristics as a function of depth.

  4. High Intensity Interval Training Favourably Affects Angiotensinogen mRNA Expression and Markers of Cardiorenal Health in a Rat Model of Early-Stage Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Patrick S. Tucker

    2015-01-01

    Full Text Available The majority of CKD-related complications stem from cardiovascular pathologies such as hypertension. To help reduce cardiovascular complications, aerobic exercise is often prescribed. Emerging evidence suggests high intensity interval training (HIIT may be more beneficial than traditional aerobic exercise. However, appraisals of varying forms of aerobic exercise, along with descriptions of mechanisms responsible for health-related improvements, are lacking. This study examined the effects of 8 weeks of HIIT (85% VO2max, versus low intensity aerobic exercise (LIT; 45–50% VO2max and sedentary behaviour (SED, in an animal model of early-stage CKD. Tissue-specific mRNA expression of RAAS-related genes and CKD-related clinical markers were examined. Compared to SED, HIIT resulted in increased plasma albumin (p=0.001, reduced remnant kidney weight (p=0.028, and reduced kidney weight-body weight ratios (p=0.045. Compared to LIT, HIIT resulted in reduced Agt mRNA expression (p=0.035, reduced plasma LDL (p=0.001, triglycerides (p=0.029, and total cholesterol (p=0.002, increased plasma albumin (p=0.047, reduced remnant kidney weight (p=0.005, and reduced kidney weight-body weight ratios (p=0.048. These results suggest HIIT is a more potent regulator of several markers that describe and influence health in CKD.

  5. Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma.

    Science.gov (United States)

    Saha, Shilpi; Bhattacharjee, Pushpak; Guha, Deblina; Kajal, Kirti; Khan, Poulami; Chakraborty, Sreeparna; Mukherjee, Shravanti; Paul, Shrutarshi; Manchanda, Rajkumar; Khurana, Anil; Nayak, Debadatta; Chakrabarty, Rathin; Sa, Gaurisankar; Das, Tanya

    2015-08-01

    Adverse side effects of chemotherapy during cancer treatment have shifted considerable focus towards therapies that are not only targeted but are also devoid of toxic side effects. We evaluated the antitumorigenic activity of sulphur, and delineated the molecular mechanisms underlying sulphur-induced apoptosis in non-small cell lung carcinoma (NSCLC) cells. A search for the underlying mechanism revealed that the choice between the two cellular processes, NFκBp65-mediated survival and p53-mediated apoptosis, was decided by the competition for a limited pool of transcriptional coactivator protein p300 in NSCLC cells. In contrast, sulphur inhibited otherwise upregulated survival signaling in NSCLC cells by perturbing the nuclear translocation of p65NFκB, its association with p300 histone acetylase, and subsequent transcription of Bcl-2. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic mitochondrial death cascade. Overall, the findings of this preclinical study clearly delineated the molecular mechanism underlying the apoptogenic effect of the non-toxic homeopathic remedy, sulphur, in NSCLC cells.

  6. Male circumcision for protection against HIV infection in sub-Saharan Africa: the evidence in favour justifies the implementation now in progress.

    Science.gov (United States)

    Wamai, Richard G; Morris, Brian J; Bailey, Robert C; Klausner, Jeffrey D; Boedicker, Mackenzie N

    2015-01-01

    This article responds to a recent 'controversy study' in Global Public Health by de Camargo et al. directed at three randomised controlled trials (RCTs) of male circumcision (MC) for HIV prevention. These trials were conducted in three countries in sub-Saharan Africa (SSA) and published in 2005 and 2007. The RCTs confirmed observational data that had accumulated over the preceding two decades showing that MC reduces by 60% the risk of HIV infection in heterosexual men. Based on the RCT results, MC was adopted by global and national HIV policy-makers as an additional intervention for HIV prevention. Voluntary medical MC (VMMC) is now being implemented in 14 SSA countries. Thus referring to MC for HIV prevention as 'debate' and viewing MC through a lens of controversy seems mistaken. In their criticism, de Camargo et al. misrepresent and misinterpret current science supporting MC for HIV prevention, omit previous denunciations of arguments similar to theirs, and ignore evidence from ongoing scientific research. Here we point out the flaws in three areas de Camargo et al. find contentious. In doing so, we direct readers to growing evidence of MC as an efficacious, safe, acceptable, relatively low-cost one-off biomedical intervention for HIV prevention.

  7. The beet cyst nematode Heterodera schachtii modulates the expression of WRKY transcription factors in syncytia to favour its development in Arabidopsis roots.

    Science.gov (United States)

    Ali, Muhammad Amjad; Wieczorek, Krzysztof; Kreil, David P; Bohlmann, Holger

    2014-01-01

    Cyst nematodes invade the roots of their host plants as second stage juveniles and induce a syncytium which is the only source of nutrients throughout their life. A recent transcriptome analysis of syncytia induced by the beet cyst nematode Heterodera schachtii in Arabidopsis roots has shown that thousands of genes are up-regulated or down-regulated in syncytia as compared to root segments from uninfected plants. Among the down-regulated genes are many which code for WRKY transcription factors. Arabidopsis contains 66 WRKY genes with 59 represented by the ATH1 GeneChip. Of these, 28 were significantly down-regulated and 6 up-regulated in syncytia as compared to control root segments. We have studied here the down-regulated genes WRKY6, WRKY11, WRKY17 and WRKY33 in detail. We confirmed the down-regulation in syncytia with promoter::GUS lines. Using various overexpression lines and mutants it was shown that the down-regulation of these WRKY genes is important for nematode development, probably through interfering with plant defense reactions. In case of WRKY33, this might involve the production of the phytoalexin camalexin.

  8. The beet cyst nematode Heterodera schachtii modulates the expression of WRKY transcription factors in syncytia to favour its development in Arabidopsis roots.

    Directory of Open Access Journals (Sweden)

    Muhammad Amjad Ali

    Full Text Available Cyst nematodes invade the roots of their host plants as second stage juveniles and induce a syncytium which is the only source of nutrients throughout their life. A recent transcriptome analysis of syncytia induced by the beet cyst nematode Heterodera schachtii in Arabidopsis roots has shown that thousands of genes are up-regulated or down-regulated in syncytia as compared to root segments from uninfected plants. Among the down-regulated genes are many which code for WRKY transcription factors. Arabidopsis contains 66 WRKY genes with 59 represented by the ATH1 GeneChip. Of these, 28 were significantly down-regulated and 6 up-regulated in syncytia as compared to control root segments. We have studied here the down-regulated genes WRKY6, WRKY11, WRKY17 and WRKY33 in detail. We confirmed the down-regulation in syncytia with promoter::GUS lines. Using various overexpression lines and mutants it was shown that the down-regulation of these WRKY genes is important for nematode development, probably through interfering with plant defense reactions. In case of WRKY33, this might involve the production of the phytoalexin camalexin.

  9. Favourable course of disease after incomplete remission on {sup 131}I therapy in children with pulmonary metastases of papillary thyroid carcinoma: 10 years follow-up

    Energy Technology Data Exchange (ETDEWEB)

    Biko, Johannes; Reiners, Christoph; Kreissl, Michael C.; Verburg, Frederik A. [University of Wuerzburg, Department of Nuclear Medicine, Wuerzburg (Germany); Demidchik, Yuri [Thyroid Cancer Centre, Minsk (Belarus); Drozd, Valentina [International Belarussian-German Foundation, Minsk (Belarus)

    2011-04-15

    The aim of this study is to report on a collective of 20 children from Belarus who had developed papillary thyroid carcinoma with pulmonary metastases after the Chernobyl disaster. In all children fractionated radioiodine therapy (RIT) was ceased before achieving complete remission due to a lack of further effects of {sup 131}I therapy and an increased risk of pulmonary fibrosis. The 20 children (12 girls) were treated with {sup 131}I using 50 MBq/kg body weight for thyroid remnant ablation and 100 MBq/kg for further therapy in intervals of 5-12 months. After five to six courses and a cumulative activity of about 24 GBq {sup 131}I no further RIT was conducted; the median thyroglobulin (TG) was 56 {mu}g/l at this time. All patients were followed for at least 10 years after cessation of RIT using diagnostic whole-body scintigraphy, CT of the chest, lung function testing and stimulated TG measurements every 1-3 years. During follow-up after the last RIT a continuous decline of values for TG levels of {proportional_to}35% per year was observed between individual visits. The median Tg level at the time of cessation of {sup 131}I therapy was 56 {mu}g/l; however, at the last visit 16 of 20 patients had a TG level {<=}10 {mu}g/l (median 2.4 {mu}g/l). Neither on diagnostic radioiodine whole-body scan nor on CT was progression of lung metastases observed. No significant pulmonary fibrosis developed. In spite of incomplete remission of thyroid cancer at cessation of RIT, a continuing spontaneous decline of TG and clinically stable partial remissions were observed in this collective of children. Therefore, if RIT does not show further effects, the administration of further courses should be handled restrictively. (orig.)

  10. The genetic basis of traits regulating sperm competition and polyandry: can selection favour the evolution of good- and sexy-sperm?

    Science.gov (United States)

    Evans, Jonathan P; Simmons, Leigh W

    2008-09-01

    The good-sperm and sexy-sperm (GS-SS) hypotheses predict that female multiple mating (polyandry) can fuel sexual selection for heritable male traits that promote success in sperm competition. A major prediction generated by these models, therefore, is that polyandry will benefit females indirectly via their sons' enhanced fertilization success. Furthermore, like classic 'good genes' and 'sexy son' models for the evolution of female preferences, GS-SS processes predict a genetic correlation between genes for female mating frequency (analogous to the female preference) and those for traits influencing fertilization success (the sexually selected traits). We examine the premise for these predictions by exploring the genetic basis of traits thought to influence fertilization success and female mating frequency. We also highlight recent debates that stress the possible genetic constraints to evolution of traits influencing fertilization success via GS-SS processes, including sex-linked inheritance, nonadditive effects, interacting parental genotypes, and trade-offs between integrated ejaculate components. Despite these possible constraints, the available data suggest that male traits involved in sperm competition typically exhibit substantial additive genetic variance and rapid evolutionary responses to selection. Nevertheless, the limited data on the genetic variation in female mating frequency implicate strong genetic maternal effects, including X-linkage, which is inconsistent with GS-SS processes. Although the relative paucity of studies on the genetic basis of polyandry does not allow us to draw firm conclusions about the evolutionary origins of this trait, the emerging pattern of sex linkage in genes for polyandry is more consistent with an evolutionary history of antagonistic selection over mating frequency. We advocate further development of GS-SS theory to take account of the complex evolutionary dynamics imposed by sexual conflict over mating frequency.

  11. Attractive toxic sugar bait (ATSB methods decimate populations of Anopheles malaria vectors in arid environments regardless of the local availability of favoured sugar-source blossoms

    Directory of Open Access Journals (Sweden)

    Beier John C

    2012-02-01

    Full Text Available Abstract Background Attractive toxic sugar bait (ATSB methods are a new and promising "attract and kill" strategy for mosquito control. Sugar-feeding female and male mosquitoes attracted to ATSB solutions, either sprayed on plants or in bait stations, ingest an incorporated low-risk toxin such as boric acid and are killed. This field study in the arid malaria-free oasis environment of Israel compares how the availability of a primary natural sugar source for Anopheles sergentii mosquitoes: flowering Acacia raddiana trees, affects the efficacy of ATSB methods for mosquito control. Methods A 47-day field trial was conducted to compare impacts of a single application of ATSB treatment on mosquito densities and age structure in isolated uninhabited sugar-rich and sugar-poor oases relative to an untreated sugar-rich oasis that served as a control. Results ATSB spraying on patches of non-flowering vegetation around freshwater springs reduced densities of female An. sergentii by 95.2% in the sugar-rich oasis and 98.6% in the sugar-poor oasis; males in both oases were practically eliminated. It reduced daily survival rates of female An. sergentii from 0.77 to 0.35 in the sugar-poor oasis and from 0.85 to 0.51 in the sugar-rich oasis. ATSB treatment reduced the proportion of older more epidemiologically dangerous mosquitoes (three or more gonotrophic cycles by 100% and 96.7%, respectively, in the sugar-poor and sugar-rich oases. Overall, malaria vectorial capacity was reduced from 11.2 to 0.0 in the sugar-poor oasis and from 79.0 to 0.03 in the sugar-rich oasis. Reduction in vector capacity to negligible levels days after ATSB application in the sugar-poor oasis, but not until after 2 weeks in the sugar-rich oasis, show that natural sugar sources compete with the applied ATSB solutions. Conclusion While readily available natural sugar sources delay ATSB impact, they do not affect overall outcomes because the high frequency of sugar feeding by mosquitoes

  12. Acid deposition study in the Asian countries

    Energy Technology Data Exchange (ETDEWEB)

    Soon, Ting-Kueh [Tunku Abdul Rahman College, Kuala Lumpur (Malaysia); Lau, Wai-Yoo [Malaysian Scientific Association, Kuala Lumpur (Malaysia)

    1996-12-31

    The Association of South East Asian Nations or ASEAN is a regional association of seven countries, namely Indonesia, Malaysia, Philippines, Singapore, Thailand, Brunei and Vietnam, located at the south eastern part of the Asian continent. Together with the East Asian States of Japan, China, Korea and Taiwan, this part of the world is experiencing rapid economic growth, especially in the last decade. Rapid industrialization has resulted in an increased demand for energy in the manufacturing and transport sectors, and also for infrastructure development. This has led to a significant increase in gaseous emissions and a corresponding increase in atmospheric acidity. Acid deposition study in the ASEAN countries began in the mid-70s when Malaysia first started her acid rain monitoring network in 1976. This was followed closely by Singapore and the other ASEAN countries in the 80s. By now all ASEAN countries have their own acid rain monitoring networks with a number of these countries extending the monitoring to dry deposition as well.

  13. Thermodynamics of gravity favours Weak Censorship Conjecture

    CERN Document Server

    Acquaviva, Giovanni; Hamid, Aymen I M; Maharaj, Sunil D

    2015-01-01

    We use the formulation of thermodynamics of gravity as proposed by Clifton, Ellis and Tavakol on the gravitational collapse of dustlike matter, that violates the strong or weak cosmic censorship conjecture depending on the initial data. We transparently demonstrate that the gravitational entropy prefers the scenario where the stronger version is violated but the weak censorship conjecture is satisfied. This is a novel result, showing the weak cosmic censorship and hence the future asymptotically simple structure of spacetime, is being validated by the nature of gravity, without imposing any extra constraint on the form of matter.

  14. Bush favours research at Pentagon and NIH

    CERN Multimedia

    MacIlwain, C

    2001-01-01

    The first budget from George W. Bush increases funding for military research and the NIH, while environmental work is drastically cut. The rest of civilian science funding is essentially frozen (1 page).

  15. Government Should Adopt Policies Favouring Rural Migrants

    Institute of Scientific and Technical Information of China (English)

    韩长赋

    2007-01-01

    Based on a systematic analysis of the development trends of Chinese rural migrant workers, this article has designed a model representing the flow of migrant workers from rural to urban areas, and the patterns of urban settlement. The significant factors contributing to the problems of migrant workers are assessed and suggestions for improvement put forward. This article concludes that the rural migrant worker problem is attributable to institutional set-up and strategy and will continue for the entire process of China’s modernization. It is estimated that modernization will be realized in about 2050, at which time the rural-urban migration process will also be completed. To solve the problems of migrant workers, a comprehensive strategy of balanced development between urban and rural areas should be carried out, featuring industry’s support of agriculture and urban support of rural areas. Furthermore, the urban-rural dual structure should be gradually eliminated through institutional reform and policy innovation. The principles of equality, humanity and fair treatment for both urban and rural populations should be sought.

  16. UNESCO Report Favours Preservation of Languages.

    Science.gov (United States)

    Runte, Roseann

    1996-01-01

    Discusses the UNESCO report "Our Creative Diversity," which links development and culture and argues that languages will not survive due to law but because of the respect given them and the milieu in which they are (or are not) used. The article points out that bilinguals are more used to switching thought patterns, have more flexible…

  17. [Favouring the work-life balance].

    Science.gov (United States)

    Masurelle, Franck

    2015-01-01

    Saint-Amand-les-Eaux general hospital, in the north of France, actively promotes quality of life at work for its staff. In 2014, during National Quality of Life at Work week, the hospital put in place a programme of activities encouraging a better work-life balance. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  18. Ombud's corner: Sincere feedback favours efficiency

    CERN Multimedia

    Vincent Vuillemin

    2012-01-01

    In this series, the Bulletin aims to explain the role of the Ombuds at CERN by presenting practical examples of misunderstandings that could have been resolved by the Ombuds if he had been contacted earlier. Please note that, in all the situations we present, the names are fictitious and used only to improve clarity.   Everyone can certainly agree that good communication is very important. Leaders should try to give feedback to their supervisees on their work and career so they can benefit from this information. Giving feedback provides personnel with an opportunity to understand what can they can improve or correct should there be some weaknesses in their technical or behavioural skills. It is also a chance to be congratulated for their efforts and dedication. Feedback should be given in a sincere and honest way, so that the person can accept the comments. The keys to giving feedback are:   • Speak the truth – even if it is difficult, have the courage to do it; &a...

  19. Detecting Lagrangian fronts with favourable fishery conditions

    CERN Document Server

    Prants, S V; Uleysky, M Yu

    2012-01-01

    Lagrangian fronts in the ocean delineate boundaries between surface waters with different Lagrangian properties. They can be accurately detected in a given velocity field by computing synoptic maps of the drift of synthetic tracers, their Lyapunov exponents, and other Lagrangian indicators. Using Russian ship's catch and location data for a number of commercial fishing seasons in the region of the northwest Pacific with one of the richest fishery in the world, it is shown that the saury fishing grounds with maximal catches are located mainly along those Lagrangian fronts where productive cold waters of the Oyashio Current, warmer waters of the southern branch of the Soya Current, and waters of warm-core Kuroshio rings converge. Computation of those fronts with the altimetric geostrophic velocity fields both in the years with the First and Second Oyashio Intrusions shows that in spite of different oceanographic conditions in both the cases the front locations may serve good indicators of potential fishing grou...

  20. Evolution of Pinggang-Liaoyuan Basin in Cretaceous and prediction of favourable exploration areas%平岗—辽源盆地白垩纪演化及有利勘探区块预测

    Institute of Scientific and Technical Information of China (English)

    陈贵标; 郝国丽; 田春燕; 李艳博; 孙哲; 刘蕾蕾; 林长城

    2013-01-01

    On the basis of regional tectonic characteristics and interpretation of seismic and electric methods, the tectonic evolution of Pinggang-Liaoyuan Basin can be divided into fault depression, depression, compression and thrust since Cretaceous. Sedimental filling in the basin influenced on hydrocarbon source rocks, reservoir and caprock through the further analysis. The main controlling factors of residual basin reservoir formation were the conditions of the hydrocarbon source rocks and preservation. According to the basin evolution and sedimental filling characteristics, we consider the Yunding-, Quantai- and Gongan sags as favourable areas for exploration.%在地震和电法解释基础上,结合区域构造特征,将平岗-辽源盆地白垩纪以来的盆地构造演化划分为断陷、坳陷、挤压逆冲3个阶段.通过进一步分析盆地沉积充填对烃源岩、储层和盖层形成的影响,认为残留盆地成藏的主控因素是烃源岩条件和保存条件.根据盆地演化和沉积充填特征的综合分析,指出云顶凹陷区、泉太凹陷和共安凹陷为有利勘探区.

  1. DETERMINING THE EFFECT (THE SOCIAL COSTS OF EXCLUSION UNDER THE SOUTH AFRICAN EXCLUSIONARY RULE: SHOULD FACTUAL GUILT TILT THE SCALES IN FAVOUR OF THE ADMISSION OF UNCONSTITUTIONALLY OBTAINED EVIDENCE?

    Directory of Open Access Journals (Sweden)

    D Ally

    2012-12-01

    Full Text Available Section 35(5 of the Constitution of the Republic of South Africa, 1996 governs the exclusion of unconstitutionally obtained evidence in criminal trials. Three groups of factors must be considered to assess whether unconstitutionally obtained evidence should either be excluded or admitted. This contribution is focussed on the third group of factors (also known as the "effect of exclusion", or the "social costs of exclusion" which consists of the "seriousness of the charge faced by the accused", and the "importance of the evidence to secure a conviction". This group of factors is concerned with the public interest in crime control. Some scholars argue that the "public mood" should be a weighty factor when our courts consider this group of factors. Against this background this article considers three issues: First, whether considerable weight should be attached to the "current mood" of society when our courts weigh and balance this group of factors against other relevant factors; secondly, whether a consideration of the "seriousness of the charge" and the "importance of the evidence for a successful prosecution" could possibly encroach upon the presumption of innocence; and, thirdly, whether factual guilt should be allowed to tip the scales in favour of the admission of unconstitutionally obtained evidence when the evidence is crucial for a conviction on a serious charge.

  2. Report of a 7 year case-control study of continuous intraperitoneal insulin infusion and subcutaneous insulin therapy among patients with poorly controlled type 1 diabetes mellitus : Favourable effects on hypoglycaemic episodes

    NARCIS (Netherlands)

    van Dijk, P. R.; Logtenberg, S. J. J.; Groenier, K. H.; Gans, R. O. B.; Bilo, H. J. G.; Kleefstra, N.

    2014-01-01

    Aims: Continuous intraperitoneal insulin infusion (CIPII) is a last-resort treatment option for patients with type 1 diabetes mellitus (T1DM) who fail to reach adequate glycaemic control with subcutaneous (SC) insulin therapy. Aim was to compare the long-term effects of CIPII and SC insulin therapy

  3. Report of a 7 year case-control study of continuous intraperitoneal insulin infusion and subcutaneous insulin therapy among patients with poorly controlled type 1 diabetes mellitus : Favourable effects on hypoglycaemic episodes

    NARCIS (Netherlands)

    van Dijk, P. R.; Logtenberg, S. J. J.; Groenier, K. H.; Gans, R. O. B.; Bilo, H. J. G.; Kleefstra, N.

    2014-01-01

    Aims: Continuous intraperitoneal insulin infusion (CIPII) is a last-resort treatment option for patients with type 1 diabetes mellitus (T1DM) who fail to reach adequate glycaemic control with subcutaneous (SC) insulin therapy. Aim was to compare the long-term effects of CIPII and SC insulin therapy

  4. Current Research in Southeast Asia.

    Science.gov (United States)

    Beh, Yolanda

    1988-01-01

    Briefly describes 22 reports on language-related research relevant to Southeast Asia, detailing study aims, methodology, researchers, and sponsors for studies conducted in Brunei Darussalam, Indonesia, Malaysia, Philippines, Singapore, and Thailand. (CB)

  5. Britain's delegation to CERN, the European Centre for Nuclear Research near Geneva, voted in favour of a project which take seven years to build, involve a 27 kilometre long tunnel, and cost 230 million pounds. Now LEP receives the go-ahead later this month

    CERN Multimedia

    Llewellyn Smith, Christopher Hubert

    1981-01-01

    Britain's delegation to CERN, the European Centre for Nuclear Research near Geneva, voted in favour of a project which take seven years to build, involve a 27 kilometre long tunnel, and cost 230 million pounds. Now LEP receives the go-ahead later this month

  6. Charles Robert Darwin (to the 200th Birthday and the 150th Anniversary of the publication of the book «On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life»

    Directory of Open Access Journals (Sweden)

    Vagin Yu. V.

    2009-10-01

    Full Text Available Charles Robert Darwin (to the 200th Birthday and the 150th Anniversary of the publication of the book «On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life»

  7. In favour of the definition "adolescents with idiopathic scoliosis": juvenile and adolescent idiopathic scoliosis braced after ten years of age, do not show different end results. SOSORT award winner 2014

    OpenAIRE

    Donzelli, Sabrina; Zaina, Fabio; Lusini, Monia; Minnella, Salvatore; Negrini, Stefano

    2014-01-01

    Background The most important factor discriminating juvenile (JIS) from adolescent idiopathic scoliosis (AIS) is the risk of deformity progression. Brace treatment can change natural history, even when risk of progression is high. The aim of this study was to compare the end of growth results of JIS subjects, treated after 10 years of age, with final results of AIS. Methods Design: prospective observational controlled cohort study nested in a prospective database. Setting: outpatient tertiary...

  8. Comparison of quality characteristics between belacan from Brunei Darussalam and Korean shrimp paste

    Directory of Open Access Journals (Sweden)

    Young-Boong Kim

    2014-12-01

    Conclusion: The protein content, pH, water activity Ca, Fe, K, P, Zn, total amino acids, essential amino acids, saturated fatty acids, and cholesterol content tended to be higher in the Korean dried shrimp paste than in Bruneian belacan and Korean fermented Saewoojeot shrimp paste.

  9. A Delphi Survey on Citizenship Education in Asean Countries: Findings for Brunei

    Science.gov (United States)

    Salleh, Hajah Sallimah Haji Mohammed; Laxman, Kumar; Jawawi, Rosmawijah

    2015-01-01

    The aim of the Delphi Survey was to elucidate Bruneian Education experts' responses to five questions regarding their knowledge and understanding of the charateristics of citizenship education viz. Environment, Coexistence, Culture, Social Justice and Equity, Democracy, Sustainable Development, Interdependence, Foreign Language, Social Welfare,…

  10. A new species of the genus Acarothrix (Acari: Halacaridae) from Brunei Darussalam and India

    Digital Repository Service at National Institute of Oceanography (India)

    Chatterjee, T.; Marshall, D.J.; Guru, B.C.; Ingole B.S.; Pesic V.

    ) in mangroves of Singapore. I. Description of three species. The Raffles Bulletin of Zoology, 54: 83-92. Proches S. 2002. New species of Copidognathinae (Acari: Halacaridae) from southern Africa. Journal of Natural History, 36: 999-1007. 6    Figure 1...

  11. EDUCATIONAL TECHNOLOGY ON TEACHING AND LEARNING OF INTEGRATED ISLAMIC EDUCATION IN BRUNEI DARUSSALAM

    Directory of Open Access Journals (Sweden)

    Ismail Suardi Wekke

    2015-03-01

    Full Text Available مستخلص:  حكومة بروناى دار السلام تقوم نشيطة بتنمية نموذج مثالى للتعليم وإدارة التربية الإسلامية بالوسائل التكنولوجية. وهذه المحاولة تدعمها مبادرة سلطان بروناى دار السلام بوصفه رئيسا للدولة. وهذه المقالة تكون معلوماتها مستمدة من حقائق الدراسة العلمية:   تكامل التربية الإسلامية واستخدامها وسائل الإتصال والإخبار التكنولجية فى عملية التعليم. هذه المحاولة المتكاملة لها أثرها النافع فى إثراء المواد الدراسية للطلاب وفى تسهيل عملية التدريس. وما كادت هذه البرامج تمضى ثمان سنوات حتى حصلت الحكومة على الإرتقاء بمقدرة الطلاب، وباستيعابهم على المواد الدارسية، وبكيفية التقويم التربوي الأصلح, وباصلاح عملية تنظيم التربية الإداري. وهذه الدراسة تحصل على أن وسائل الإخبار والإتصال التكنولوجية تتساير وتقدم التربية الإسلامية تسايرا متكاملا فى ترقية ذكاء الطلاب. Abstrak:  Pemerintah Brunai Darussalam giat mengembangkan model pembelajaran dan administrasi pendidikan Islam dengan menjadikan teknologi sebagai fasilitator. Upaya itu didorong oleh prakarsa Sultan Brunai Darussalam, kepala negara sekaligus sultan negara itu. Makalah ini mengemukakan hasil penelitian tentang integrasi pendidikan Islam dan penggunaan teknologi komunikasi dan informasi. Integrasi tersebut memberikan manfaat dalam pengayaan materi dan memudahkan proses pembelajaran. Setelah delapan tahun berjalan, program itu mampu mendorong kepada peningkatan kemampuan siswa, penguasaan materi pelajaran yang lebih terarah, evaluasi yang berkualitas, dan perbaikan pengelolaan administrasi pendidikan. Penelitian ini menunjukkan bahwa teknologi informasi dapat bersinergi dengan pendidikan Islam sehingga pembelajaran menghasilkan kecerdasan bagi peserta didik.

  12. Is blood donation induced low iron status associated with favourable levels of OxLDL, s-ICAM-1, sVCAM-1 and vWF-antigen in healthy men.

    NARCIS (Netherlands)

    Hoydonck, P.G.A.; Schouten, E.G.; Hoppenbrouwers, K.P.M.; Temme, E.H.M.

    2004-01-01

    The potential effect of iron depletion by blood donation and its relevance to cardiovascular diseases are still under debate. Markers of vascular integrity are increasingly applied in investigations of atherothrombotic diseases. In this study, we investigated whether a lower iron status through

  13. Eosinophils elicit proliferation of naive and fungal-specific cells in vivo so enhancing a T helper type 1 cytokine profile in favour of a protective immune response against Cryptococcus neoformans infection.

    Science.gov (United States)

    Garro, Ana P; Chiapello, Laura S; Baronetti, Jose L; Masih, Diana T

    2011-10-01

    Experimental Cryptococcus neoformans infection in rats has been shown to have similarities with human cryptococcosis, because as in healthy humans, rats can effectively contain cryptococcal infection. Moreover, it has been shown that eosinophils are components of the immune response to C. neoformans infections. In a previous in vitro study, we demonstrated that rat peritoneal eosinophils phagocytose opsonized live yeasts of C. neoformans, thereby triggering their activation, as indicated by the up-regulation of MHC and co-stimulatory molecules and the increase in interleukin-12, tumour necrosis factor-α and interferon-γ production. Furthermore, this work demonstrated that C. neoformans-specific CD4(+) and CD8(+) T lymphocytes cultured with these activated C. neoformans-pulsed eosinophils proliferated, and produced important amounts of T helper type 1 (Th1) cytokines in the absence of Th2 cytokine synthesis. In the present in vivo study, we have shown that C. neoformans-pulsed eosinophils are also able to migrate into lymphoid organs to present C. neoformans antigens, thereby priming naive and re-stimulating infected rats to induce T-cell and B-cell responses against infection with the fungus. Furthermore, the antigen-specific immune response induced by C. neoformans-pulsed eosinophils, which is characterized by the development of a Th1 microenvironment with increased levels of NO synthesis and C. neoformans-specific immunoglobulin production, was demonstrated to be able to protect rats against subsequent infection with fungus. In summary, the present work demonstrates that eosinophils act as antigen-presenting cells for the fungal antigen, hence initiating and modulating a C. neoformans-specific immune response. Finally, we suggest that C. neoformans-loaded eosinophils might participate in the protective immune response against these fungi.

  14. Evaluating Students' Understanding of Kinetic Particle Theory Concepts Relating to the States of Matter, Changes of State and Diffusion: A Cross-National Study

    Science.gov (United States)

    Treagust, David F.; Chandrasegaran, A. L.; Crowley, Julianne; Yung, Benny H. W.; Cheong, Irene P.-A.; Othman, Jazilah

    2010-01-01

    This paper reports on the understanding of three key conceptual categories relating to the kinetic particle theory: (1) intermolecular spacing in solids, liquids and gases, (2) changes of state and intermolecular forces and (3) diffusion in liquids and gases, amongst 148 high school students from Brunei, Australia, Hong Kong and Singapore using 11…

  15. Report on metric study tour to Republic of South Africa

    Energy Technology Data Exchange (ETDEWEB)

    Laner, F. J.

    1978-01-01

    The modernized metric system, known universally as the International System of Units (abbreviated SI under the French name) was renamed in 1960 by the world body on standards. A map shows 98 percent of the world using or moving toward adoption of SI units. Only the countries of Burma, Liberia, Brunei, and Southern Yemen are nonmetric. The author describes a two-week session in Pretoria and Johannesburg on metrication, followed by additional meetings on metrication in Rhodesia. (MCW)

  16. ¿SON LAS COOPERATIVAS MÁS FAVORABLES A LA PRESENCIA DE MUJERES EN LOS CONSEJOS QUE OTRAS ENTIDADES? / ARE THE COOPERATIVES IN MORE FAVOURABLE OF HAVING WOMEN IN THEIR BOARD OF DIRECTORS THAN OTHER ENTITIES?

    Directory of Open Access Journals (Sweden)

    María Luisa ESTEBAN SALVADOR

    2013-01-01

    Full Text Available Este trabajo analiza en qué empresas se cuenta con órganos de gobierno más favorables a la participación femenina en el periodo previo al desarrollo de medidas y recomendaciones sobre la presencia de mujeres en los consejos de administración de las grandes sociedades españolas, entre las que se incluyen cooperativas. Asimismo pone en relación la rentabilidad con el género en sus órganos de gobierno. Para ello, en un primer análisis se analiza la rentabilidad económica de las sociedades no financieras cotizadas en el mercado continuo y de aquellas que aunque no cotizan en dicho mercado están obligadas a presentar un Informe Anual de Gobierno Corporativo a la Comisión Nacional del Mercado de Valores desde el año 2004. Posteriormente se reduce la muestra tras la exclusión de las empresas no cotizadas en el mercado continuo. Los resultados muestran que una única entidad contribuyó a cambiar la rentabilidad y se coloca como modelo de estudio. Una característica diferenciadora de esta empresa es su forma jurídica, ya que se trata de una empresa cooperativa. / This paper analyzes which companies have more women on their board of directors in the moment previous to the publication of measures and recommendations about the female presence on the boards of directors of the Spanish big companies, including cooperatives. At the same time the study puts in relation the gender on boards with the return on assets. First, the current work starts with the sample of non-financial firms obliged to present an Annual Corporate Governance Report to the Spanish Securities Market Commission with data from 2004. Second, the sample is reduced; excluding the companies not listed in the continuous market. The results indicate that only one company contributed to change the return on assets and becomes a model to study. One characteristic of this entity is their juridical form, as a cooperative.

  17. The sizes, masses and specific star-formation rates of massive galaxies at 1.3favour of evolution via minor mergers

    CERN Document Server

    McLure, R J; Dunlop, J S; Cirasuolo, M; Curtis-Lake, E; Bruce, V A; Caputi, K; Almaini, O; Bonfield, D G; Bradshaw, E J; Buitrago, F; Chuter, R; Foucaud, S; Hartley, W G; Jarvis, M J

    2012-01-01

    We report the results of a comprehensive study of the relationship between galaxy size, stellar mass and specific star-formation rate (sSFR) at redshifts 1.3= 6x10^10 Msun), spectroscopic sample from the UKIDSS Ultra-deep Survey (UDS), with accurate stellar-mass measurements derived from spectro photometric fitting, we find that at z~1.4 the location of massive galaxies on the size-mass plane is determined primarily by their sSFR. At this epoch we find that massive galaxies which are passive (sSFR <= 0.1 Gyr^-1) follow a tight size-mass relation, with half-light radii a factor f=2.4+/-0.2 smaller than their local counterparts. Moreover, amongst the passive sub-sample we find no evidence that the off-set from the local size-mass relation is a function of stellar population age. Based on a sub-sample with dynamical mass estimates we also derive an independent estimate of f=2.3+/-0.3 for the typical growth in half-light radius between z~1.4 and the present day. Focusing on the passive sub-sample, we conclude ...

  18. Una ingesta inadecuada de manganeso podría contribuir a la aparición de resistencia a la insulina en niñas An inadequate intake of manganese may favour insulin resistance in girls

    Directory of Open Access Journals (Sweden)

    E. Rodríguez-Rodríguez

    2011-10-01

    Full Text Available Objetivo: Estudiar la relación entre la adecuación de la ingesta de manganeso (Mn y los niveles de glucosa, de insulina y la existencia de resistencia a la insulina en escolares sanos de la Comunidad de Madrid (España. Material y métodos: Se estudiaron 573 escolares entre 8 y 13 años. La ingesta de energía y nutrientes (entre ellos el Mn se determinó mediante un registro del consumo de alimentos durante 3 días. La ingesta de Mn se comparó con las Ingestas Adecuadas (IA existentes para dicho mineral. Los parámetros antropométricos estudiados fueron el peso y la talla y se determinó el índice de masa corporal (IMC a partir de los mismos. Se determinaron los niveles de insulina y glucosa en ayunas y se calculó el índice HOMA para determinar la presencia de resistencia a la insulina en los escolares. Resultados: Las niñas con ingesta de Mn inadecuadas (no llegaron a cubrir el 100% de las IA presentaron, a su vez, mayores niveles de insulina y de HOMA que las niñas con ingestas superiores o iguales al 100% de las IA marcadas. Al tener en cuenta diferentes factores de confusión (ingesta energética, ingesta de hidratos de carbono y lípidos, IMC y edad, se observó una relación positiva y significativa entre la cobertura de las IA de Mn y los niveles de HOMA en niñas. Conclusión: Se destaca la importancia de cubrir el 100% de las IA de Mn en las niñas con el fin de prevenir la aparición de resistencia a la insulina y una futura diabetes tipo 2.Aim: to study the relationship between an adequate manganese (Mn intake and glucose, insulin levels and insulin resistance among healthy children from Madrid (Spain. Materials and methods: 573 schoolchildren between 8 and 13 years old were studied. Energy and nutrients intake (especially Mn was calculated with a "3-day diet record". Mn intake was compared to Adequate Intakes (AI for this mineral. Weight and height were measured and body mass index (BMI calculated. Fasting glucose and

  19. Elevated pCO(2 )favours nitrate reduction in the roots of wild-type tobacco (Nicotiana tabacum cv. Gat.) and significantly alters N-metabolism in transformants lacking functional nitrate reductase in the roots.

    Science.gov (United States)

    Kruse, Jörg; Hetzger, Ilka; Hänsch, Robert; Mendel, Ralf-R; Walch-Liu, Pia; Engels, Christof; Rennenberg, Heinz

    2002-12-01

    The impact of elevated pCO(2 )on N-metabolism of hydroponically grown wild-type and transformed tobacco plants lacking root nitrate reduction was studied in order to elucidate the effects on (i) nitrate uptake, (ii) long-distance transport of N, (iii) nitrate reduction with emphasis on root-NR, and (iv) the allocation of N between the root and shoot. The findings were related to alterations of growth rates. At elevated pCO(2 )the wild type exhibited higher growth rates, which were accompanied by an increase of NO(3)(-)-uptake per plant, due to a higher root:shoot ratio. Furthermore, elevated pCO(2 )enhanced nitrate reduction in the roots of the wild type, resulting in enhanced xylem-loading of organic N (amino-N) to supply the shoot with sufficient nitrogen, and decreased phloem-transport of organic N in a basipetal direction. Transformed tobacco plants lacking root nitrate reduction were smaller than the wild type and exhibited lower growth rates. Nitrate uptake per plant was decreased in transformed plants as a consequence of an impeded root growth and, thus, a significantly decreased root:shoot ratio. Surprisingly, transformed plants showed an altered allocation of amino-N between the root and the shoot, with an increase of amino-N in the root and a substantial decrease of amino-N in the shoot. In transformed plants, xylem-loading of nitrate was increased and the roots were supplied with organic N via phloem transport. Elevated pCO(2 )increased shoot-NR, but only slightly affected the growth rates of transformed plants, whereas carbohydrates accumulated at elevated pCO(2 )as indicated by a significant increase of the C/N ratio in the leaves of transformed plants. Unexpectedly, the C/N balance and the functional equilibrium between root and shoot growth was disturbed dramatically by the loss of nitrate reduction in the root.

  20. Innovation Processes of SMEs in Less Favoured Municipalities of Portugal

    Directory of Open Access Journals (Sweden)

    Maura Helena Couto de Sousa

    2012-01-01

    Full Text Available This paper examines the innovation processes of Small and MediumEnterprises (SMEs in peripheral areas, particularly in the municipality of Guardaand in the islands of Sao Miguel and Santa Maria in the Azores. For this purpose, asurvey was conducted, and three models were estimated: a Logit model, to measurethe difference between firms that innovate and those that do not; a Tobit model,to measure the intensity of innovation; and a Probit model to analyze the type ofinnovation. The results show a positive relationship between the introduction of innovationsin the market sector and the age and activity of the companies, an inverserelationship in regards to the size of the company and in relation to the region.

  1. Anthracycline-induced cardiomyopathy: favourable effects of cardiac resynchronization therapy

    DEFF Research Database (Denmark)

    Ahlehoff, Ole; Galløe, Anders M; Hansen, Peter R

    2010-01-01

    We report a case of severe refractory congestive heart failure after anthracycline chemotherapy in a patient with a narrow QRS interval on the electrocardiogram and echocardiographic evidence of left ventricular dyssynchrony, where cardiac resynchronization therapy resulted in normalization of left...

  2. Order on programmes of assistance favouring emigrants, 15 January 1988.

    Science.gov (United States)

    1988-01-01

    This Order sets forth programs of assistance containing the following categories of aid: 1) aid for elderly emigrants who are Spanish or in the process of recovering Spanish citizenship and are ill and incapable of working; 2) aid to cover the extraordinary costs related to emigration or the return of Spanish emigrant workers and their families who are in a state of need; 3) aid to facilitate the integration into the workplace of returned Spanish emigrants who are unemployed; 4) aid for emigrant centers, associations, and federations helping Spanish emigrants; 5) aid to organizations to improve the assistance and hospital and cultural activities that they provide to Spanish emigrants; 6) aid to organizations that promote professional and occupational orientation and training to facilitate the professional promotion and insertion in the workplace of Spanish emigrant workers; 7) aid to Spanish emigrants and their families resident abroad who have special abilities and wish to pursue higher education and lack the means to do so in Spain; 8) aid to young Spanish emigrants resident abroad to promote their participation in cultural, sociocultural, artistic, and youth activities; 9) aid to promote the social integration of foreign workers in Spain; and 10) aid to programs involving the exchange of young workers within the European Economic Community. Further provisions of the Order deal with beneficiaries of aid, documentation required, and applications, among other things. This Order repeals provisions of an Order of 30 January 1987 (Boletin Oficial del Estado, No. 42, 18 February 1987, pp. 4952-4964) on the same topic in so far as those provisions are in conflict with the provisions of this Order.

  3. Favourable results of Mohs micrographic surgery for basal cell carcinoma

    DEFF Research Database (Denmark)

    Gniadecki, Robert; Glud, Martin; Mortensen, Kia;

    2015-01-01

    INTRODUCTION: Basal cell carcinoma (BCC) is the most common malignant neoplasm with an annual incidence approaching 200/100,000 person-years. Mohs micrographic surgery (MMS) is widely used in North America and in Europe for treatment of BCC. This technique ensures radical tumour removal, sparing...... defects than standard excisions with 4 or 6 mm margins. Closure of skin defects was achieved by side-to-side closure in 49% and by local flaps in 40%. There were no relapses during the observation time. The safety, cosmetic and functional outcome were excellent. CONCLUSIONS: We recommend that MMS...

  4. "All in Favour, Say Aye!" Voting in Pupils' Collaborative Talk

    Science.gov (United States)

    Newman, Ruth

    2015-01-01

    This paper draws on the findings of an Economic and Social Research Council and British Telecom-funded project which explored the teaching of collaborative talk in the secondary English classroom. During the analysis of the video data collected, voting was observed as a strategy in pupils' collaborative decision-making. Converse to its democratic…

  5. Climbing favours the tripod gait over alternative faster insect gaits

    Science.gov (United States)

    Ramdya, Pavan; Thandiackal, Robin; Cherney, Raphael; Asselborn, Thibault; Benton, Richard; Ijspeert, Auke Jan; Floreano, Dario

    2017-02-01

    To escape danger or catch prey, running vertebrates rely on dynamic gaits with minimal ground contact. By contrast, most insects use a tripod gait that maintains at least three legs on the ground at any given time. One prevailing hypothesis for this difference in fast locomotor strategies is that tripod locomotion allows insects to rapidly navigate three-dimensional terrain. To test this, we computationally discovered fast locomotor gaits for a model based on Drosophila melanogaster. Indeed, the tripod gait emerges to the exclusion of many other possible gaits when optimizing fast upward climbing with leg adhesion. By contrast, novel two-legged bipod gaits are fastest on flat terrain without adhesion in the model and in a hexapod robot. Intriguingly, when adhesive leg structures in real Drosophila are covered, animals exhibit atypical bipod-like leg coordination. We propose that the requirement to climb vertical terrain may drive the prevalence of the tripod gait over faster alternative gaits with minimal ground contact.

  6. Favourable results of Mohs micrographic surgery for basal cell carcinoma

    DEFF Research Database (Denmark)

    Gniadecki, Robert; Glud, Martin; Mortensen, Kia

    2015-01-01

    was 66.1 years. The most common localisations were the forehead (31.3%), the nose (31.0%) and the cheek (14.7%). Primary BCC comprised 54.0%; the remaining cases were relapses, most frequently after curettage (36.9%), radiotherapy (18.9%) and photodynamic therapy (11.7%). MMS leads to 40% smaller skin......INTRODUCTION: Basal cell carcinoma (BCC) is the most common malignant neoplasm with an annual incidence approaching 200/100,000 person-years. Mohs micrographic surgery (MMS) is widely used in North America and in Europe for treatment of BCC. This technique ensures radical tumour removal, sparing...... of the surrounding healthy skin, and it also offers higher cure rates than standard tumour excision with a predefined margin of healthy skin. The superiority of MMS relies on the fact that the entire (100%) margin of the excised tissue is examined microscopically for residual tumour in contrast to the traditional...

  7. Bioactive metabolite production by Streptomyces albolongus in favourable environment

    Directory of Open Access Journals (Sweden)

    Myn Uddin

    2013-06-01

    Full Text Available Objectives: Demand for new antibiotic is rising up due to continuous resistance risk against conventional antibiotic.This attempt was taken to find out a novel antimicrobial metabolite.Methods: Chili field antagonistic actinomycetes Streptomyces albolongus was isolated and tested for optimum antimicrobialmetabolite production. Primary screening was done by selective media and antibiotic assay was done by agarcup plate method. Fermented product was recovered by separating funnel using suitable solvent.Results: Maximum antimicrobial metabolite production was found at temperature 35°C and pH 9.0 and on 6th day ofincubation. The medium consisting of corn steep liquor (0.2%, glucose (1.0%, NaCl (0.5%, K2HPO4 (0.1% was screenedout as suitable medium for maximum antimicrobial production. Sucrose was found as the best carbon source amongfour sources. The antimicrobial metabolite was found to be stable at pH and temperature up to 11.0 and 100°C respectively.The active agent was best extracted with chloroform. The antimicrobial spectrum of the metabolite was wideand shows activity against Shigella dysenteriae (AE14612, Shigella sonnei (CRL, ICDDR, B, Salmonella typhi (AE14296,Vibrio cholerae (AE14748, Pseudomonas aeruginosa (CRL, ICDDR, B, Bacillus cereus (BTCC19, Staphylococcus aureus(ATCC6538, Bacillus subtilis (BTTC17 and Bacillus megaterium (BTTC18.Conclusions: The findings of antibacterial activity of S. albolongus against several species of human pathogens includingboth Gram-positive and Gram-negative bacteria indicated that our produced material might be an alternative antimicrobialsubstance to control human diseases. J Microbiol Infect Dis 2013; 3(2: 75-82Key words: Streptomyces albolongus, antimicrobial metabolite, optimum production, antimicrobial spectrum

  8. Creation of Favourable Conditions for Introducing Hydrogen Fuel in Russia

    Science.gov (United States)

    Boretsky, E.; Egorova, M.

    2016-06-01

    The paper presents the key problems that hinder the introduction of new fuel for Russian automobile manufacturers. By analyzing the energy market, as well as trends and forecasts of crude oil and petroleum product prices, it proposes the necessary steps for the Government, along with oil producers and automakers, to gradually convert motor vehicles to hydrogen fuel and, therefore, to occupy a high-potential niche in the energy market. The recommended steps are assumed to be applicable not only to this specific case - introduction of hydrogen to the Russian market - but also to any other alternative fuel in a country with the similar or superior national economy.

  9. Dreams in cyberculture: transmediality in favour of serial narratives

    Directory of Open Access Journals (Sweden)

    Jéssica de Oliveira da S. Silveira

    2017-06-01

    Full Text Available In 2003, Janet Murray already pointed the junction between TV and the Internet as the future of narratives in cyberculture. Today, what the autor called hiperseriado forma tis a reality with the development of narratives that unfold from the TV to the web. This work aims to observe, from Malhação show at Globo, and in the light of semiotics theory, how is this narrative expansion to another media.--- DOI: http://dx.doi.org/10.22409/cadletrasuff.2017n54a416

  10. The Most-Favoured-Nation Principle in the EU

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2007-01-01

    Artiklen analyserer i hvilket omfang der i EU gælder et mest-begunstigelsesprincip på baggrund af EF-domstolens praksis om de frie bevægeligheder for varer, tjenesteydelser, personer og kapital. Endelig vurderes det hvordan WTO-retten påvirker og supplere dette princip....

  11. The Most-Favoured-Nation Principle in the EU

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2007-01-01

    Artiklen analyserer i hvilket omfang der i EU gælder et mest-begunstigelsesprincip på baggrund af EF-domstolens praksis om de frie bevægeligheder for varer, tjenesteydelser, personer og kapital. Endelig vurderes det hvordan WTO-retten påvirker og supplere dette princip....

  12. Biological efficacy of the ecotoxically favourable insecticides and ...

    African Journals Online (AJOL)

    Administrator

    2011-05-30

    May 30, 2011 ... insecticides and their mixture in the control of gypsy moth. Mara Tabaković-Tošić ... gypsy moths, in progragation phase, when the number of pests is relatively small. When the number is .... invertebrate animals. Treatment of ...

  13. Lower hybrid current drive favoured by electron cyclotron radiofrequency heating

    Energy Technology Data Exchange (ETDEWEB)

    Cesario, R.; Cardinali, A.; Castaldo, C.; Marinucci, M.; Tuccillo, A. A. [Associazione EURATOM/ENEA sulla Fusione, Centro Ricerche Frascati, 00044, Frascati (Italy); Amicucci, L.; Galli, A. [Università di Roma Sapienza, Dipartimento Ingegneria Elettronica, Rome (Italy); Giruzzi, G. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Napoli, F.; Schettini, G. [Università di Roma Tre, Dipartimento Ingegneria Elettronica, Rome (Italy)

    2014-02-12

    The important goal of adding to the bootstrap a fraction of non-inductive plasma current, which would be controlled for obtaining and optimizing steady-state profiles, can be reached by using the Current Drive produced by Lower Hybrid waves (LHCD). FTU (Frascati Tokamak Upgrade) experiments demonstrated, indeed, that LHCD is effective at reactor-graded high plasma density, and the LH spectral broadening is reduced, operating with higher electron temperature in the outer region of plasma column (T{sub e-periphery}). This method was obtained following the guidelines of theoretical predictions indicating that the broadening of launched spectrum produced by parametric instability (PI) should be reduced, and the LHCD effect at high density consequently enabled, under higher (T{sub e-periphery}). In FTU, the temperature increase in the outer plasma region was obtained by operating with reduced particle recycling, lithized walls and deep gas fuelling by means of fast pellet. Heating plasma periphery with electron cyclotron resonant waves (ECRH) will provide a further tool for achieving steady-state operations. New FTU experimental results are presented here, demonstrating that temperature effect at the plasma periphery, affecting LH penetration, occurs in a range of plasma parameters broader than in previous work. New information is also shown on the modelling assessing frequencies and growth rates of the PI coupled modes responsible of spectral broadening. Finally, we present the design of an experiment scheduled on FTU next campaign, where ECRH power is used to slightly increase the electron temperature in the outer plasma region of a high-density discharge aiming at restoring LHCD. Consequent to model results, by operating with a toroidal magnetic field of 6.3 T, useful for locating the electron cyclotron resonant layer at the periphery of the plasma column (r/a∼0.8, f{sub 0}=144 GHz), an increase of T{sub e} in the outer plasma (from 40 eV to 80 eV at r/a∼0.8) is expected by the JETTO code, sufficient for recovering LHCD. An ECRH power of 0.8 MW, and the standard FTU regime at high plasma density (n{sub eav}∼1.3×10{sup 20}m{sup −3} and plasma current of 0.5 MA) have been considered. The code has been set with transport modelling to reproduce the evolution of FTU kinetic profiles.

  14. Which bulges are favoured by barred S0 galaxies?

    CERN Document Server

    Barway, Sudhanshu; Vaghmare, Kaustubh; Kembhavi, Ajit K

    2016-01-01

    S0 galaxies are known to host classical bulges with a broad range of size and mass, while some such S0s are barred and some not. The origin of the bars has remained as a long-standing problem -- what made bar formation possible in certain S0s? By analysing a large sample of S0s with classical bulges observed by the Spitzer space telescope, we find that most of our barred S0s host comparatively low-mass classical bulges, typically with bulge-to-total ratio ($B/T$) less than $0.5$; whereas S0s with more massive classical bulges than these do not host any bar. Furthermore, we find that amongst the barred S0s, there is a trend for the longer and massive bars to be associated with comparatively bigger and massive classical bulges -- possibly suggesting bar growth being facilitated by these classical bulges. In addition, we find that the bulge effective radius is always less than the bar effective radius --indicating an interesting synergy between the host classical bulge and bars being maintained while bar growth ...

  15. Favourable results of Mohs micrographic surgery for basal cell carcinoma

    DEFF Research Database (Denmark)

    Gniadecki, Robert; Glud, Martin; Mortensen, Kia

    2015-01-01

    INTRODUCTION: Basal cell carcinoma (BCC) is the most common malignant neoplasm with an annual incidence approaching 200/100,000 person-years. Mohs micrographic surgery (MMS) is widely used in North America and in Europe for treatment of BCC. This technique ensures radical tumour removal, sparing ...

  16. Argument in favour of descriptive theory of names.

    Directory of Open Access Journals (Sweden)

    Erkki Ahlstrom

    2011-04-01

    Full Text Available Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4 Normal 0 21 false false false ES X-NONE X-NONE MicrosoftInternetExplorer4

  17. Innovation Processes of SMEs in Less Favoured Municipalities of Portugal

    Directory of Open Access Journals (Sweden)

    Maria Manuela Natário

    2012-01-01

    Full Text Available Este artículo examina los procesos de innovación de las pequeñas y medianas empresas (PYME en las zonas periféricas, en particular en el municipio de Guarda y en las islas de Sao Miguel y Santa María en las Azores. Para este fin se construyó una encuesta para ser aplicada en las áreas de negocio antes mencionadas y la metodología utilizada es la estimación de tres modelos: en primerlugar un modelo logit, para medir la diferencia entre las empresas que innovan y las que no innovan; en segundo lugar un modelo Tobit, para medir la intensidad dela innovación, y el tercero, un modelo Probit, para analizar el tipo de innovación. Las conclusiones apuntan a la existencia de una relación positiva entre la variable independiente: la introducción de innovaciones en el sector del mercado y las variables edad, y la actividad, una relación inversa en lo que respecta al tamaño de la empresa y en menor grado en relación con la variable región.

  18. Modelling of the Duero Sedimentary Basin and Selection of Deep Favourable Geological Formations for Supercritical CO{sub 2} Storage; Modelizacion del Subsuelo de la Cuenca del Duero y Seleccion de Formaciones Favorables para el Almacenamiento de CO{sub 2} en Estado Supercritico

    Energy Technology Data Exchange (ETDEWEB)

    Prado, A. J.; Perez del Villar, L.; Pelayo, M.; Recreo, F.

    2008-04-10

    Currently, the Deep Geological Storage is the internationally most accepted option to store CO{sub 2}, whose main goal is to reduce the CO{sub 2} emissions to the atmosphere. This work, which has been carried out in the frame of The Strategic Singular Project entitled: CO{sub 2} generation, capture and storage advanced technologies summarizes a general methodology focused on the selection and modelling of favourable formations to store CO{sub 2} and to estimate their storage capacity. To conclude, the Duero basin suitability to allocate a CO{sub 2} storage plant has been quantified by integrating the Multi-criteria Evaluation Methods with the corresponding developed Geographical Information Systems. (Author) 45 refs.

  19. Ethical values in emergency medical services: A pilot study.

    Science.gov (United States)

    Bremer, Anders; Herrera, María Jiménez; Axelsson, Christer; Martí, Dolors Burjalés; Sandman, Lars; Casali, Gian Luca

    2015-12-01

    Ambulance professionals often address conflicts between ethical values. As individuals' values represent basic convictions of what is right or good and motivate behaviour, research is needed to understand their value profiles. To translate and adapt the Managerial Values Profile to Spanish and Swedish, and measure the presence of utilitarianism, moral rights and/or social justice in ambulance professionals' value profiles in Spain and Sweden. The instrument was translated and culturally adapted. A content validity index was calculated. Pilot tests were carried out with 46 participants. This study conforms to the ethical principles for research involving human subjects and adheres to national laws and regulations concerning informed consent and confidentiality. Spanish professionals favoured justice and Swedish professionals' rights in their ambulance organizations. Both countries favoured utilitarianism least. Gender differences across countries showed that males favoured rights. Spanish female professionals favoured justice most strongly of all. Swedes favour rights while Spaniards favour justice. Both contexts scored low on utilitarianism focusing on total population effect, preferring the opposite, individualized approach of the rights and justice perspectives. Organizational investment in a utilitarian perspective might jeopardize ambulance professionals' moral right to make individual assessments based on the needs of the patient at hand. Utilitarianism and a caring ethos appear as stark opposites. However, a caring ethos in its turn might well involve unreasonable demands on the individual carer's professional role. Since both the justice and rights perspectives portrayed in the survey mainly concern relationship to the organization and peers within the organization, this relationship might at worst be given priority over the equal treatment and moral rights of the patient. A balanced view on ethical perspectives is needed to make professionals observant and

  20. Regional enteritis and gluten-free diet. A clinical study

    NARCIS (Netherlands)

    Merwe, Christiaan Frederik van der

    1974-01-01

    The purpose of this clinical study was to determine whether the use of a gluten-free diet influenced the course and prognosis of regional enteritis. Following a few clinical communications in the Dutch medical literature reporting favourable results obtained with the gluten-free diet in the

  1. Regional enteritis and gluten-free diet. A clinical study

    NARCIS (Netherlands)

    Merwe, Christiaan Frederik van der

    1974-01-01

    The purpose of this clinical study was to determine whether the use of a gluten-free diet influenced the course and prognosis of regional enteritis. Following a few clinical communications in the Dutch medical literature reporting favourable results obtained with the gluten-free diet in the treatmen

  2. S.E.M. study of urease-induced crystalluria in the presence of hydroxamic derivatives.

    Science.gov (United States)

    Ben Amar, M; L'Espérance, G; Tawashi, R

    1986-01-01

    The effect of 3 hydroxamic acid derivatives on urease-induced crystalluria was studied in vitro. Acetohydroxamic acid is more effective than salicylhydroxamic and gentisohydroxamic acids in inhibiting the kinetic of urease enzymatic reaction and in retarding the formation of struvite and apatite. Crystal deposits studied by scanning electron microscope (S.E.M.) and X-ray microanalysis indicated that acetohydroxamic acid favours the formation of large crystals of struvite, and less aggregation is observed. Salicyl and gentiso derivatives favour the formation of brushite together with struvite and apatite.

  3. Facilitating Group Analysis of Two Case Studies Utilising Peer Tutoring: Comparison of Tasks and Outcomes

    Science.gov (United States)

    Fong, Lin Siew

    2016-01-01

    Peer-tutoring sessions of two groups of advanced diploma in financial accounting students with mixed proficiency were analysed thoroughly in this study. Numerous studies in peer tutoring have produced favourable results to both tutors and tutees due to the scaffolding process which promotes effective learning. However, there is a lack of studies…

  4. Contributions of sociodemographic factors to criminal behavior

    Directory of Open Access Journals (Sweden)

    Mundia L

    2016-06-01

    Full Text Available Lawrence Mundia, Rohani Matzin, Salwa Mahalle, Malai Hayati Hamid, Ratna Suriani Osman Psychological Studies and Human Development Academic Group, Sultan Hassanal Bolkiah Institute of Education, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei Abstract: We explored the extent to which prisoner sociodemographic variables (age, education, marital status, employment, and whether their parents were married or not influenced offending in 64 randomly selected Brunei inmates, comprising both sexes. A quantitative field survey design ideal for the type of participants used in a prison context was employed to investigate the problem. Hierarchical multiple regression analysis with backward elimination identified prisoner marital status and age groups as significantly related to offending. Furthermore, hierarchical multinomial logistic regression analysis with backward elimination indicated that prisoners’ age, primary level education, marital status, employment status, and parental marital status as significantly related to stealing offenses with high odds ratios. All 29 nonrecidivists were false negatives and predicted to reoffend upon release. Similarly, all 33 recidivists were projected to reoffend after release. Hierarchical binary logistic regression analysis revealed age groups (24–29 years and 30–35 years, employed prisoner, and primary level education as variables with high likelihood trends for reoffending. The results suggested that prisoner interventions (educational, counseling, and psychotherapy in Brunei should treat not only antisocial personality, psychopathy, and mental health problems but also sociodemographic factors. The study generated offending patterns, trends, and norms that may inform subsequent investigations on Brunei prisoners. Keywords: crimes, prisoner, sociodemographic, recidivism, interventions, Brunei

  5. Ab-initio study of the coadsorption of Li and H on Pt(001), Pt(110) and Pt(111) surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Saad, Farida [Laboratoire de Physique et Chimie Quantique, Faculte des Sciences, Universite Mouloud Mammeri, 15000 Tizi-Ouzou (Algeria); Zemirli, Mourad, E-mail: zemirlimourad@mail.ummto.dz [Laboratoire de Physique et Chimie Quantique, Faculte des Sciences, Universite Mouloud Mammeri, 15000 Tizi-Ouzou (Algeria); Benakki, Mouloud; Bouarab, Said [Laboratoire de Physique et Chimie Quantique, Faculte des Sciences, Universite Mouloud Mammeri, 15000 Tizi-Ouzou (Algeria)

    2012-02-15

    The coadsorption of Li and H atoms on Pt(001), Pt(110) and Pt(111) surfaces is studied using density functional theory with generalised gradient approximation. In all calculations Li, H and the two topmost layers of the metal were allowed to relax. At coverage of 0.25 mono-layer in a p(2 Multiplication-Sign 2) unit cell, lithium adsorption at the hollow site for the three surfaces is favoured over top and bridge sites. The most favoured adsorption sites for H atom on the Pt(001) and Pt(110) surfaces are the top and bridge sites, while on Pt(111) surface the fcc site appears to be slightly favoured over the hcp site. The coadsorption of Li and atomic hydrogen shows that the interaction between the two adsorbates is stabilising when they are far from each other. The analysis of Li, H and Pt local density of states shows that Li strongly interacts with the Pt surfaces.

  6. Study to assess knowledge, attitude and practice regarding swine flu vaccine amongst medical students

    Directory of Open Access Journals (Sweden)

    Rajvardhan R. Solunke

    2016-10-01

    Conclusions: This study shows high knowledge, favourable attitude but poor practice towards Swine flu vaccination amongst medical students. So there is need to increase awareness for vaccination of swine flu amongst medical students by continuous health education and also need to increase the availability of vaccine in government hospitals. [Int J Basic Clin Pharmacol 2016; 5(5.000: 1978-1983

  7. Gender Difference in the Use of Thought Representation--A Corpus-Based Study

    Science.gov (United States)

    Riissanen, Anne; Watson, Greg

    2014-01-01

    This study (Note 1) investigates potential differences in language use between genders, by applying a modified model of thought representation. Our hypothesis is that women use more direct forms of thought representation than men in modern spoken British English. Women are said to favour "private speech" that creates intimacy and…

  8. [Clinical studies on pramipexol retard].

    Science.gov (United States)

    Klivényi, Péter; Vécsei, László

    2010-05-30

    Pramipexol retard is the newest drug for the treatment of Parkinson's disease. The prolonged release of the agent in this preparation allows a more continuous dopaminergic stimulation than previous preparations, without reducing the agent's already known and proven clinical efficiency. In addition, it has a more favourable adverse effect profile than previous preparations, and patient compliance can also be better as it needs to be taken only once daily. These benefits have been proven in recent clinical studies, of which the most important ones are reviewed here.

  9. Computers in Science and Mathematics Education in the ASEAN Region.

    Science.gov (United States)

    Talisayon, Vivien M.

    1989-01-01

    Compares policies and programs on computers in science and mathematics education in the six ASEAN countries: Brunei, Indonesia; Malaysia, Philippines, Singapore, and Thailand. Limits discussion to the computer as a teaching aid and object of study, attendant problems, and regional cooperation. (MVL)

  10. Integrating the Use of Interdisciplinary Learning Activity Task in Creating Students' Mathematical Knowledge

    Science.gov (United States)

    Mahanin, Hajah Umisuzimah Haji; Shahrill, Masitah; Tan, Abby; Mahadi, Mar Aswandi

    2017-01-01

    This study investigated the use of interdisciplinary learning activity task to construct students' knowledge in Mathematics, specifically on the topic of scale drawing application. The learning activity task involved more than one academic discipline, which is Mathematics, English Language, Art, Geography and integrating the Brunei Darussalam…

  11. The Verb in Philippine English: A Preliminary Analysis of Modal Would

    Science.gov (United States)

    Bautista, Ma. Lourdes S.

    2004-01-01

    Taking its inspiration from a study conducted by Svalberg of Brunei English verb usage (1998), this paper examines the responses of a sample of 205 Filipino university freshmen to grammatically correct and incorrect verb forms in a 20-item Grammaticality Judgment Test. The test covered tense harmony, verb forms, tenses, and modals. Except in the…

  12. Changes in lifestyle habits after counselling by nurse practitioners : 1-year results of the Groningen Overweight and Lifestyle study

    NARCIS (Netherlands)

    ter Bogt, Nancy C. W.; Milder, Ivon E. J.; Bemelmans, Wanda J. E.; Beltman, Frank W.; Broer, Jan; Smit, Andries J.; van der Meer, Klaas

    2011-01-01

    Objectives: The Groningen Overweight and Lifestyle (GOAL) study primarily aims at preventing weight gain by nurse practitioners (NP) guided by a standardized computerized software program. Since favourable changes in physical activity (PA) and diet may improve health independently of weight (loss),

  13. Changes in lifestyle habits after counselling by nurse practitioners : 1-year results of the Groningen Overweight and Lifestyle study

    NARCIS (Netherlands)

    ter Bogt, Nancy C. W.; Milder, Ivon E. J.; Bemelmans, Wanda J. E.; Beltman, Frank W.; Broer, Jan; Smit, Andries J.; van der Meer, Klaas

    2011-01-01

    Objectives: The Groningen Overweight and Lifestyle (GOAL) study primarily aims at preventing weight gain by nurse practitioners (NP) guided by a standardized computerized software program. Since favourable changes in physical activity (PA) and diet may improve health independently of weight (loss),

  14. The study of lepton EDM in CP violating BLMSSM

    Science.gov (United States)

    Zhao, Shu-Min; Feng, Tai-Fu; Zhan, Xi-Jie; Zhang, Hai-Bin; Yan, Ben

    2015-07-01

    In the supersymmetric model with local gauged baryon and lepton numbers (BLMSSM), the CP violating effects are considered to study the lepton electric dipole moment (EDM). The CP violating phases in BLMSSM are more than those in the standard model (SM) and can give large contributions. The analysis of the EDMs for the leptons e, μ, τ is shown in this work. It is in favour of exploring the source of CP violation and probing the physics beyond SM.

  15. Study

    Directory of Open Access Journals (Sweden)

    Susan Grandy

    2012-01-01

    Full Text Available Purpose. This study examined the association between self-reported weight change and quality of life, and exercise and weight management behaviors among individuals with type 2 diabetes mellitus (T2DM. Methods. In the US SHIELD study, respondents reported whether they had lost or gained weight compared with 1 year earlier and completed the SHIELD-WQ-9 quality of life questionnaire as well as provided information on their exercise and weight management behaviors in the past 12 months. Results. Sixteen percent of the respondents reported gaining weight (n=460, and 30% reported losing weight (n=895. More respondents who reported losing weight exercised regularly, limited calorie and fat intake, and increased fiber, fruit, and vegetable intake compared with respondents who reported gaining weight (P<0.01. For all nine aspects of daily life, a significantly greater proportion of respondents who reported losing weight reported improved well-being (12%–44% compared with respondents who reported gaining weight (P<0.0001. Conclusions. Self-reported weight loss was associated with improved well-being, better exercise, and weight management behaviors among individuals with T2DM.

  16. Study

    Directory of Open Access Journals (Sweden)

    Erum Zahir

    2017-05-01

    Full Text Available Physicochemical properties like density, viscosity, boiling point, saponification value (SV, iodine value (IV,and peroxide value (PV of Corn and Mustard oils were studied to evaluate the compositional quality of oils and also to investigate the effect on the use of same oil for repeated frying as it ultimately changes the physicochemical, nutritional and sensory properties of the oil. FT-IR spectroscopy was used to evaluate the degree of oxidation after heating and frying processes. Results revealed that due to the temperature change in the oil there is a notable difference in the spectral band which showed that the proportions of the fatty acids were changed. The spectra of Corn oil at the boiling point and at multiple frying times with a piece of potato showed frequencies in range of 2852.7–2926.0 cm−1 while in Mustard oil an additional peak was observed at 3633.8 cm−1 which exhibits the secondary oxidized product formation.

  17. Understanding misunderstanding: a study of sex differences in meaning attribution.

    Science.gov (United States)

    Trofimova, Ira

    2013-11-01

    There are biologically based sex differences in verbal abilities and in neuropsychological systems of verbal processing. Measurement of observable behaviour, however, does not say much about sex differences in the internal, semantic processing of verbal material. The present study, which was conducted in Canada, China and Russia, investigated sex differences in connotative meaning attribution to the most common concepts using an object scale symmetry in the choice of the nouns and bipolar adjectives (projective semantic method). The results showed that males had a tendency to estimate reality- and work-related concepts more negatively and social- and physical attractors more positively than women. The paper hypothesizes that at the level of the most fundamental semantic processing men favour more exceptional objects than women, and women favour more predictable objects, including rules and routines.

  18. Rationale, design and baseline characteristics of the CANagliflozin cardioVascular Assessment Study-Renal (CANVAS-R) : A randomized, placebo-controlled trial

    NARCIS (Netherlands)

    Neal, Bruce; Perkovic, Vlado; Matthews, David R.; Mahaffey, Kenneth W.; Fulcher, Greg; Meininger, Gary; Erondu, Ngozi; Desai, Mehul; Shaw, Wayne; Vercruysse, Frank; Yee, Jacqueline; Deng, Hsiaowei; de Zeeuw, Dick

    Aims: The primary aim of the CANagliflozin cardioVascular Assessment Study-Renal (CANVAS-R) is to determine whether the favourable effects of inhibition of the sodium glucose co-transporter 2 (SGLT2) on blood glucose, blood pressure and body weight are accompanied by protection against adverse renal

  19. [Ultrastructural study of embryonic development in Grantia compressa F. (Porifera, Calcarea)].

    Science.gov (United States)

    Gallissian, M F

    1983-01-01

    The embryonic development of Grantia compressa is studied by means of the electron microscope from the blastula inside the mesenchyme to the mature amphi-blastula released in the excurrent canals. The study of the different cellular categories of the embryon shows the distribution of the vitellin inclusions and their evolution. The ultrastructure of the "cellules en croix" is not in favour of a photoreceptor part.

  20. Study of the environmental effects of sanitary landfill in Pinto, Madrid (Spain); Estudio de la influencia del vertedero de residuos solidos urbanos de Pinto (Comunidad de Madrid) y su entorno

    Energy Technology Data Exchange (ETDEWEB)

    Dorronsoro, J.L.; Carreras, N.; Sanchez, D.M.; Quejido, A.; Sanchez, M.; Herranz, I.; Fernandez, M.E.

    1996-10-01

    Here we report the results obtained in the studies of the environmental affection of a municipal solid waste (MSW) Landfill (Pinto, spain). For this purpose samples of waters, soils, sediments, vegetation and leachates were analyzed during three years (1990-1993). The results do not indicate environmental affection, due to the favourable situation (low permeability and runoff and low population density) of the landfill.

  1. Adsorption of neopentane on HNaY-FAU zeolite studied by IR spectroscopy

    Science.gov (United States)

    Kiricsi, I.; Tasi, Gy.; Förster, H.; Fejes, P.

    1994-01-01

    Adsorption of neopentane on HNaY-FAU zeolite was studied by IR spectroscopy. At beam temperature neopentane already shows a weak interaction with Brønsted acidic sites. At high temperatures, irreversible consumption of both Brønsted and Lewis sites is observed. According to the results of quantum chemical calculations a proton attack on the central carbon of neopentane seems to be favoured.

  2. Potential interest of a development of a radiotherapy scheme in stereotactic conditions with dose escalation focused on the tumour in the case of prostate cancers with a favourable prognostic; Interet potentiel de developper un schema de radiotherapie en conditions stereotaxiques avec escalade de dose focalisee dans la tumeur dans les cancers de prostate de pronostic favorable

    Energy Technology Data Exchange (ETDEWEB)

    Chapet, O.; De Bari, B. [Service de radiotherapie-oncologie, centre hospitalier Lyon Sud, 69 - Pierre-Benite (France); Udrescu, C.; Sotton, M.P.; Jalade, P. [Service de physique medicale, centre hospitalier Lyon Sud, 69 - Pierre-Benite (France); Rouviere, O. [Service de radiologie urologique, hopital Edouard-Herriot, 69 - Lyon (France); Bouffard-Vercelli, J. [Service de radiologie, centre hospitalier Lyon Sud, 69 - Pierre-Benite (France)

    2010-10-15

    Irradiation in stereotactic conditions is an irradiation technique used in the case of low risk prostate cancer. Several fractionations have already been assessed. Recent advances in MRI technology allowed a more precise visualization of macroscopic tumours in the prostate and therefore offer the possibility of a focal increase of irradiation dose in the tumour. The authors report a study aiming at assessing the interest of developing an original scheme of radiotherapy in stereotactic conditions with a focal increase of irradiation. Dosimetric scanographies of nine patients have been used. The prostate and the tumour have been contoured. Two planning target volumes have been determined. For each patient, an intensity-modulated conformation radiotherapy plan has been optimized with three different dose levels. As a result, the authors notice that the dose increase in the prostate significantly limits the doses received by the rectum and the bladder. Short communication

  3. Properties of molten Ge chalcogenides an ab initio molecular dynamics study

    CERN Document Server

    Raty, J Y; Bichara, C

    2003-01-01

    In this study, we perform first-principles molecular dynamics simulations of the eutectic alloy Ge sub 1 sub 5 Te sub 8 sub 5 at five different densities and temperatures. We obtain structures in agreement with the available diffraction data and obtain a new view of the molten Ge chalcogenides. We show that the anomalous volume contraction observed in the liquid 30 K above the eutectic temperature corresponds to a significant change of the Ge-Te partial structure factor. The detailed structural analysis shows that volume variations observed upon melting in Ge sub 1 sub 5 Te sub 8 sub 5 , as in liquid GeSe and GeTe, can be explained in terms of the competition between two types of local environment of the germanium atoms. A symmetrical coordination octahedron is entropically favoured at high temperature, while an asymmetrical octahedron resulting from the local manifestation of the Peierls distortion is electronically favoured at lower temperatures.

  4. Chemistry of carbonization - I. A theoretical study of free radical formation from starting materials

    Energy Technology Data Exchange (ETDEWEB)

    Ruette, F.; Sierraalta, A.; Castells, V.; Laya, M. (Instituto Venezolano de Investigaciones Cientificas, Caracas (Venezuela). Laboratorio de Quimica Computacional)

    1993-01-01

    The effect of size, shape, and aromaticity in the formation of radicals from model polyaromatic hydrocarbons (PAH) was theoretically studied using the MINDO/3 method. The results were interpreted in terms of hydrogen transfer on carbonization and liquefaction processes of coal-related compounds. Additives that donate or withdraw electrons were modeled by calculating negatively or positively charged systems. The results show that the hydrogen donating properties of PAHs increase with the increase of their molecular weights. The formation of anionic [pi]-radicals is thermodynamically favoured, contrary to cationic [pi]-radicals. Negative charge favoured the formation of low molecular weight radicals, and therefore, the hydrogen transfer from light to heavy PAHs. Positive charges, in general, do not facilitate the hydrogen transfer. 42 refs., 2 figs., 4 tabs.

  5. Nursing Professionals Use and Value Information but Favour Work-based Sources and Colleagues in Preference to Libraries. A review of: Urquhart, C., and R. Davies. ”EVINCE: The Value of Information in Developing Nursing Knowledge and Competence.” Health Libraries Review 14.2 (1997: 61‐72.

    Directory of Open Access Journals (Sweden)

    Andrew Booth

    2007-12-01

    Full Text Available Objective – To examine the impact of information on the clinical knowledge and practice of nurses, midwives and health visitors.Design – Two surveys: a one-page critical incident questionnaire survey sent weekly over four weeks, and a questionnaire attached to information requests and searches, followed up by interviews.Setting – UK health information providers serving nurses (national information providers, National Health Service trust libraries, higher education funded library and information services, and a health promotion library. Subjects – A random sample of 210 nurses, midwives and health visitors were targeted in the critical incident survey, and 776 of those requesting information or searches at participating library and information centres received questionnaires for the second survey.Methods – Opinion leaders were consulted to inform a pilot study. A critical incident type questionnaire survey was then administered to a random sample of 210 nurses, midwives and health visitors. The same one‐page questionnaire was sent weekly (for four weeks to 10% of a randomly selected sample of staff at each site. Staff were asked to identify one occasion during that week when they needed information, the purpose of theinformation needed, the sources chosen to answer the query and how successful the quest was. The impact of the information provided by the library and information services on present and future professional practice was examined through a complementary survey. Responses were coded using three categories of competence: assessment, monitoring of care andevaluation of care. Follow‐up interviews then explored the nature of the incident described or the quality of information provided.Main results – The response rate for the critical incident survey was 52% (434 out of 840 completed questionnaires returned with 78% (163/210 of participants replying at least once. The total response rate for the second survey was 40% (311

  6. Rehabilitating mangrove ecosystem services: A case study on the relative benefits of abandoned pond reversion from Panay Island, Philippines.

    Science.gov (United States)

    Duncan, Clare; Primavera, Jurgenne H; Pettorelli, Nathalie; Thompson, Julian R; Loma, Rona Joy A; Koldewey, Heather J

    2016-08-30

    Mangroves provide vital climate change mitigation and adaptation (CCMA) ecosystem services (ES), yet have suffered extensive tropics-wide declines. To mitigate losses, rehabilitation is high on the conservation agenda. However, the relative functionality and ES delivery of rehabilitated mangroves in different intertidal locations is rarely assessed. In a case study from Panay Island, Philippines, using field- and satellite-derived methods, we assess carbon stocks and coastal protection potential of rehabilitated low-intertidal seafront and mid- to upper-intertidal abandoned (leased) fishpond areas, against reference natural mangroves. Due to large sizes and appropriate site conditions, targeted abandoned fishpond reversion to former mangrove was found to be favourable for enhancing CCMA in the coastal zone. In a municipality-specific case study, 96.7% of abandoned fishponds with high potential for effective greenbelt rehabilitation had favourable tenure status for reversion. These findings have implications for coastal zone management in Asia in the face of climate change.

  7. Identifying Effective Pedagogical Approaches for Online Workplace Training: A case study of the South African wood products manufacturing sector

    Directory of Open Access Journals (Sweden)

    Ian S. Macdonald

    2007-11-01

    Full Text Available This study investigated appropriate pedagogical techniques for workplace e-learning programs in the South African wood products (furniture manufacturing sector. The study found that learners responded favourably to constructivist teaching approaches, such as asynchronous discussions, open-ended task-based activities, and assignments incorporating authentic, real-world examples. Learners viewed constructivist activities to be more useful than quizzes and traditional essay-based assignments, as they allowed new concepts to be learned in context and were perceived to promote deeper understanding of the subject matter. Nevertheless, they valued the inclusion of a blend of pedagogical approaches in the course design, as this enabled them to approach and analyze new concepts in an assortment of ways. Learners placed importance on regular interaction with other learners and course instructors, and were strongly in favour of including face-to-face components in Web-based courses.

  8. Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA

    DEFF Research Database (Denmark)

    Skov, Joan; Bryld, Torsten; Lindegaard, Dorthe

    2011-01-01

    We report the synthesis of two C4'-modified DNA analogues and characterize their structural impact on dsDNA duplexes. The 4'-C-piperazinomethyl modification stabilizes dsDNA by up to 5°C per incorporation. Extension of the modification with a butanoyl-linked pyrene increases the dsDNA stabilization...... modifications are tolerated in DNA:RNA hybrids but leave their melting temperatures virtually unaffected. Fluorescence data indicate that the pyrene moiety is residing outside the helix. The available data suggest that the DNA discrimination is due to (i) the positive charge of the piperazino ring having...... to a maximum of 9°C per incorporation. Using fluorescence, ultraviolet and nuclear magnetic resonance (NMR) spectroscopy, we show that the stabilization is achieved by pyrene intercalation in the dsDNA duplex. The pyrene moiety is not restricted to one intercalation site but rather switches between multiple...

  9. Off-farm employment and income poverty in favourable agro-climatic areas of Tanzania

    DEFF Research Database (Denmark)

    Msinde, John Victor; Urassa, Justin K.; Nathan, Iben

    2016-01-01

    in the first quarter of 2014 in five villages of Kilombero Valley, Tanzania using a structured questionnaire. Income poverty was analysed using the Foster-Greer-Thorbecke (FGT) poverty index and two stage least square (2SLS) regression. Households with off-farm employment income were found to be less poor......Income poverty in Tanzania as elsewhere in developing countries is predominantly a rural phenomenon and affects largely households relying on subsistence farming. This is despite the fact that poverty reduction strategies have devoted increasing attention on the role farm employment in enhancing...... household income. This paper argues that, off-farm employment may have potential to contribute to reduction of rural households’ income poverty. Hence the main objective of the paper is set to examine effects of off-farm employment on income poverty. Data was collected from a random sample of 309 households...

  10. Diagnosis of polymyalgia rheumatica usually means a favourable outcome for your patient

    Directory of Open Access Journals (Sweden)

    Marcin Milchert

    2017-01-01

    Full Text Available Polymyalgia rheumatica (PMR is a unique disease of elderly people, traditionally diagnosed based on a clinical picture. A typical case is a combination of severe musculoskeletal symptoms and systemic inflammatory response with spectacular response to corticosteroids treatment. The severity of symptoms may be surprising in older patients where immunosenescence is normally expected. However, PMR may be diagnosed in haste if there is a temptation to use this diagnosis as a shortcut to achieve rapid therapeutic success. Overdiagnosis of PMR may cause more problems compared to underdiagnosis. The 2012 PMR criteria proposed by European League against Rheumatism/American College of Rheumatology aim to minimize the role of clinical intuition and build on more objective features. However, questions arise if this is possible in PMR. This has been discussed in this review.

  11. High concentrations of H2O2 make aerobic glycolysis energetically more favourable than cellular respiration.

    Directory of Open Access Journals (Sweden)

    Hamid R Molavian

    2016-08-01

    Full Text Available Since the original observation of the Warburg Effect in cancer cells, over eight decades ago, the major question of why aerobic glycolysis is favored over oxidative phosphorylation has remained unresolved. An understanding of this phenomenon may well be the key to the development of more effective cancer therapies. In this paper, we use a semi-empirical method to throw light on this puzzle. We show that aerobic glycolysis is in fact energetically more favorable than oxidative phosphorylation for concentrations of peroxide (H2O2 above some critical threshold value. The fundamental reason for this is the activation and high engagement of the pentose phosphate pathway (PPP in response to the production of reactive oxygen species H2O2 by mitochondria and the high concentration of H2O2 (produced by mitochondria and other sources. This makes oxidative phosphorylation an inefficient source of energy since it leads (despite high levels of ATP production to a concomitant high energy consumption in order to respond to the hazardous waste products resulting from cellular processes associated with this metabolic pathway. We also demonstrate that the high concentration of H2O2 results in an increased glucose consumption, and also increases the lactate production in the case of glycolysis.

  12. Does the particle creation mechanism favour the formation of a black hole or a naked singularity?

    CERN Document Server

    Bhattacharjee, Sudipto; Chakraborty, Subenoy

    2016-01-01

    The paper deals with collapse dynamics of a spherically symmetric massive star in the framework of non-equilibrium themodynamic prescription through particle creation mechanism. The matter content in the star is in the form of perfect uid with barotropic equation of state and the dissipative phenomena due to non-equilibrium thermodynamics is in the form of bulk viscosity. For simplicity, the thermodynamic system is chosen to be adiabatic (i.e., isentropic) so that the e?ective bulk viscous pressure is linearly related to the particle creation rate. As a result, the evolution of the collapsing star also depends on the particle creation rate. By proper choice of creation rate as a function of the Hubble parameter, it is found that the end state of the collapse may be either a black hole or a naked singularity.

  13. Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases.

    Science.gov (United States)

    Häusler, M; Kluger, G; Nikanorova, M

    2011-02-01

    Epilepsy with myoclonic absences (EMA) is a rare epileptic syndrome with frequently poor response to antiepileptic treatment. Rufinamide (RUF) is a relatively new EMEA- and FDA-approved anticonvulsant licensed as an orphan drug for the adjunctive treatment of patients with Lennox-Gastaut syndrome. A retrospective data analysis in 3 patients was performed. Add-on RUF treatment was initiated in 3 boys with EMA refractory to conventional antiepileptic therapy (primidone + valproic acid, n=1; levetiracetame + ethosuximide, n=2). It resulted in complete cessation of all seizures in 2, and a 50% reduction of the seizure frequency in one child, respectively. RUF add-on therapy should be considered in children with EMA not responding to conventional antiepileptic therapy. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Speed over efficiency: locusts select body temperatures that favour growth rate over efficient nutrient utilization

    DEFF Research Database (Denmark)

    Miller, Gabriel A; Clissold, Fiona J; Mayntz, David

    2009-01-01

    to investigate relationships between growth/development and macronutrient utilization (conversion of ingesta to body mass) as a function of temperature. A range of macronutrient intake values for insects at 26, 32 and 38°C was achieved by offering individuals high-protein diets, high-carbohydrate diets......Ectotherms have evolved preferences for particular body temperatures, but the nutritional and life-history consequences of such temperature preferences are not well understood. We measured thermal preferences in Locusta migratoria (migratory locusts) and used a multi-factorial experimental design...... or a choice between both. Locusts placed in a thermal gradient selected temperatures near 38°C, maximizing rates of weight gain; however, this enhanced growth rate came at the cost of poor protein and carbohydrate utilization. Protein and carbohydrate were equally digested across temperature treatments...

  15. Liberalisation of the energy market: a favourable supply-side shock for the UK economy

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, C.

    1994-06-01

    This discussion paper outlines the situation before privatisation and liberation, before examining the extent of liberalisation, and finally the broader effects of energy privatisation and liberalisation which covers the shedding of surplus labour, the limited effects on prices, specific factors in electricity, and the extent of the shock. (UK)

  16. Vegetable and fruit: the evidence in their favour and the public health perspective.

    Science.gov (United States)

    Trichopoulou, Antonia; Naska, Androniki; Antoniou, Anna; Friel, Sharon; Trygg, Kerstin; Turrini, Aida

    2003-03-01

    There is strong evidence that the intake of vegetables and fruits reduces the risk of cardiovascular disease (CVD) and is inversely associated with several forms of cancer. In contrast, information concerning specific macro- or micronutrients in relation to chronic diseases is limited and largely inconclusive. The beneficial role of vegetable and fruit consumption can also be inferred by considering the health effects of two dietary patterns, the Mediterranean and Japanese ones, in both of which the consumption of plant foods holds a prominent position. Time-trend data, retrieved from the DAFNE databank on the vegetable and fruit availability in four European countries (Greece, Ireland, Italy and Norway) indicate that, during the last decade, fruit availability decreased in Greece and Italy and increased in Ireland and Norway, whereas vegetable availability decreased only in Italy. In Greece, Italy and Norway, the daily fruit availability was higher than that of vegetables, a dietary pattern not in accordance to recommendations for higher vegetable consumption. This information, which is crucial for nutrition policies and health education, also demonstrates the value of the DAFNE surveillance system.

  17. Acute pancreatitis, acute hepatitis and acute renal failure favourably resolved in two renal transplant recipients.

    Science.gov (United States)

    Voiculescu, Mihai; Ionescu, Camelia; Ismail, Gener; Mandache, Eugen; Hortopan, Monica; Constantinescu, Ileana; Iliescu, Olguta

    2003-03-01

    Renal transplantation is often associated with severe complications. Except for acute rejection, infections and toxicity of immunosuppressive treatment are the most frequent problems observed after transplantation. Infections with hepatic viruses (HBV, HDV, HCV, HGV) and cytomegalic virus (CMV) are the main infectious complications after renal transplantation. Cyclosporine toxicity is not unusual for a patient with renal transplantation and is even more frequent for patients with hepatic impairment due to viral infections. The subjects of this report are two renal transplant recipients with acute pancreatitis, severe hepatitis and acute renal failure on graft, receiving immunosuppressive therapy for maintaining renal graft function

  18. Future Climate Change Will Favour Non-Specialist Mammals in the (Sub)Arctics

    OpenAIRE

    Hof, Anouschka R.; Roland Jansson; Christer Nilsson

    2012-01-01

    Arctic and subarctic (i.e., [sub] arctic) ecosystems are predicted to be particularly susceptible to climate change. The area of tundra is expected to decrease and temperate climates will extend further north, affecting species inhabiting northern environments. Consequently, species at high latitudes should be especially susceptible to climate change, likely experiencing significant range contractions. Contrary to these expectations, our modelling of species distributions suggests that predic...

  19. Experimental setup for rapid crystallization using favoured chemical potential and hydrodynamic conditions

    Indian Academy of Sciences (India)

    V K Dixit; B V Rodrigues; H L Bhat

    2001-10-01

    The rapid crystallization of KH2PO4 (KDP) from solution is demonstrated at a rate up to ≈7.5 mm/day along [100] and 22 mm/day along [001] in a crystallizer of 5 l capacity, using accelerated crucible rotation technique (ACRT) and simulated platform geometry for controlling the hydrodynamic conditions. On an experimental basis we have grown the crystals up to 40 × 43 × 66 mm3 size in about 3 days. Comparative analysis of the main structural and optical properties of crystals grown by conventional and rapid crystallization technique, is discussed.

  20. Overcoming "Being" in Favour of Knowledge: The Fixing Effect of "Matauranga"

    Science.gov (United States)

    Mika, Carl Te Hira

    2012-01-01

    It is common to hear Maori discuss primordial states of Being, yet in colonisation those very central beliefs are forced into weaker utterances. In this process those utterances merely conform to a colonised agenda. "Matauranga", a tidy term that overwhelmingly refers to an epistemological knowing of the world, colludes nicely with its…

  1. Leukemia inhibitory factor favours neurogenic differentiation of long-term propagated human midbrain precursor cells

    DEFF Research Database (Denmark)

    Andersen, Rikke K; Widmer, Hans R; Zimmer, Jens;

    2009-01-01

    , human embryonic (5 weeks post-conception) ventral mesencephalic (VM) precursor cells were propagated as neural tissue-spheres (NTS) in epidermal growth factor (EGF; 20 ng/ml) and fibroblast growth factor 2 (FGF2; 20 ng/ml). After more than 325 days, the NTS were transferred to media containing either...... EGF+FGF2, EGF+FGF2+heparin or leukemia inhibitory factor (LIF; 10 ng/ml)+FGF2+heparin. Cultures were subsequently propagated for more than 180 days with NTS analyzed at various time-points. Our data show for the first time that human VM neural precursor cells can be long-term propagated as NTS...... in the presence of EGF and FGF2. A positive effect of heparin was found only after 150 days of treatment. After switching into different media, only NTS exposed to LIF contained numerous cells positive for markers of newly formed neurons. Besides of demonstrating the ability of human VM NTS to be long...

  2. Optimum contribution selection combined with weighting rare favourable alleles increases long-term genetic gain

    DEFF Research Database (Denmark)

    Liu, Huiming; Sørensen, Anders Christian; Berg, Peer

    simulated by combining GEBV or wGEBV and truncation selection (TS) or OCS. Optimum contribution selection was further categorized into OCSA and OCSG depending on whether pedigree (A) or genomic data (G) was used for penalizing average co-ancestry. The selection was performed for 40 generations. It was shown...

  3. Solvent engineering and other reaction design methods for favouring enzyme-catalysed synthesis

    DEFF Research Database (Denmark)

    Zeuner, Birgitte

    for FAE-catalysed acylation reactions was reviewed. FAE type A from Aspergillus niger and an FAE from a commercial preparation from Humicola insolens, Depol 740L, could not catalyse the esterification of arabinose or xylose with hydroxycinnamates in IL-buffer systems or in surfactantless microemulsion......, the biocatalytic productivity was increased more than 9-fold as a result of the enzyme recovery. In conclusion, where the use of non-conventional media is required for catalysis, e.g. in the thermodynamically controlled FAE-catalysed esterification, careful selection of both solvent system and the FAE itself...

  4. Which regional features of Danish agriculture favour the corn bunting in the contemporary farming landscape?

    DEFF Research Database (Denmark)

    Fox, Anthony David; Heldbjerg, Henning

    2008-01-01

    Corn buntings Miliaria calandra were abundant throughout arable agricultural landscapes in Europe, but have catastrophically declined since the mid 1970s with changes in farming practice and now give serious conservation cause for concern. Corn buntings declined in Denmark during 1976......-1993, but (almost unique in Europe) have since increased (by up to 11% per annum) in some areas without specific conservation recovery actions. Based on breeding bird surveys in the mid 1990s, highest corn bunting densities occurred on mixed agriculture in west Denmark (Jylland); the species was rarer or absent...... in regions of highest arable land cover. Corn bunting density and extent of rotational and permanent grassland were correlated, but not with spring sown barley (all known to constitute important corn bunting winter habitat). The extent of spring barley rapidly declined in Denmark during the 1980s, but since...

  5. A severe genotype with favourable outcome in very long chain acyl-CoA dehydrogenase deficiency

    Science.gov (United States)

    Touma, E; Rashed, M; Vianey-Saban, C; Sakr, A; Divry, P; Gregersen, N; Andresen, B

    2001-01-01

    A patient with very long chain acyl-CoA dehydrogenase (VLCAD) deficiency is reported. He had a severe neonatal presentation and cardiomyopathy. He was found to be homozygous for a severe mutation with no residual enzyme activity. Tandem mass spectrometry on dried blood spots revealed increased long chain acylcarnitines. VLCAD enzyme activity was severely decreased to 2% of control levels. Dietary management consisted of skimmed milk supplemented with medium chain triglycerides and L-carnitine. Outcome was good and there was no acute recurrence.

 PMID:11124787

  6. Which regional features of Danish agriculture favour the corn bunting in the contemporary farming landscape?

    DEFF Research Database (Denmark)

    Fox, Anthony David; Heldbjerg, Henning

    2008-01-01

    Corn buntings Miliaria calandra were abundant throughout arable agricultural landscapes in Europe, but have catastrophically declined since the mid 1970s with changes in farming practice and now give serious conservation cause for concern. Corn buntings declined in Denmark during 1976......-1993, but (almost unique in Europe) have since increased (by up to 11% per annum) in some areas without specific conservation recovery actions. Based on breeding bird surveys in the mid 1990s, highest corn bunting densities occurred on mixed agriculture in west Denmark (Jylland); the species was rarer or absent...... in regions of highest arable land cover. Corn bunting density and extent of rotational and permanent grassland were correlated, but not with spring sown barley (all known to constitute important corn bunting winter habitat). The extent of spring barley rapidly declined in Denmark during the 1980s, but since...

  7. Pre-pubertal males practising Taekwondo exhibit favourable postural and neuromuscular performance.

    Science.gov (United States)

    Jlid, Mohamed Chedly; Maffulli, Nicola; Souissi, Nisar; Chelly, Mohamed Souheil; Paillard, Thierry

    2016-01-01

    The postural and neuromuscular performances in healthy children taekwondo (TKD) practitioners in comparison with control children were examined. Seventeen healthy pre-pubertal males undertaking only physical education at school (age: 11.88 ± 0.33 years) and 12 pre-pubertal male TKD practitioners (>3 years, 4 sessions a week) (age 11.66 ± 0.49 years) were recruited. Performances in the dynamic postural control (Star Excursion Balance Test -SEBT), vertical jump [squat jump (SJ) and countermovement jump (CMJ)] and sprint running (distances: 5, 10, 20 and 30 m) tests were compared between the two groups. The performances of the TKD practitioners were better than those of the non-TKD active for the SEBT (for 14 of 16 conditions, p  0.05). TKD practice would stimulate sensory input and motor output of the postural system that would enhance its efficiency. In addition, the dynamic nature of TKD would develop the muscle power of the lower limbs. In our sample of healthy pre-pubertal males, TKD appears to improve postural and neuromuscular functions, but further research is required.

  8. [Thrombosis of the right atrium after umbilical venous catheterization. Favourable outcome after early thrombectomy].

    Science.gov (United States)

    Paupe, A; Lenclen, R; Blanc, P; Chassevent, J; Hoenn, E; Molho, M; Zannier, D; Olivier-Martin, M

    1992-02-01

    A case of right atrial thrombosis after venous umbilical catheterization in a 21 day-old premature newborn is reported. The initiating factors of such an accident and its clinical signs are evocated. The authors emphasize the value of a systematic ultrasonographic supervision of newborns with central catheters for a long period of time and the value of surgical thrombectomy.

  9. An acidic pectin lyase from Aspergillus niger with favourable efficiency in fruit juice clarification.

    Science.gov (United States)

    Xu, S X; Qin, X; Liu, B; Zhang, D Q; Zhang, W; Wu, K; Zhang, Y H

    2015-02-01

    The pectin lyase gene pnl-zj5a from Aspergillus niger ZJ5 was identified and expressed in Pichia pastoris. PNL-ZJ5A was purified by ultrafiltration, anion exchange and gel chromatography. The Km and Vmax values determined using citrus pectin were 0.66 mg ml(-1) and 32.6 μmol min(-1) mg(-1) , respectively. PNL-ZJ5A exhibited optimal activity at 43°C and retained activity over 25-50°C. PNL-ZJ5A was optimally active at pH 5 and effective in apple juice clarification. Compared with controls, PNL-ZJ5A increased the fruit juice yield significantly. Furthermore, PNL-ZJ5A reduced the viscosity of apple juice by 38.8% and increased its transmittance by 86.3%. PNL-ZJ5A combined with a commercial pectin esterase resulted in higher juice volume.

  10. Preventive or punitive disciplinary measures in South African schools: Which should be favoured?

    Directory of Open Access Journals (Sweden)

    I.J. Oosthuizen

    2003-08-01

    Full Text Available Recent research shows a major paradigm shift towards preventive and positive rather than punitive disciplinary measures. Since the essence of learner discipline is correctional and educational rather than punitive, this approach seems to be the correct one – especially after the abolition of corporal punishment in South African schools. However, the question remains: is there still room for punitive and reactive learner discipline in our schools? And if so, which is the better approach, and where should the emphasis be? This article endeavours to evaluate the two approaches by means of a normative framework. Rather than ruling which approach is the more successful one, the authors argue that it is not the one or the other, but rather a combination of the two approaches. One of the guiding determinants for correct decision-making is vested in maintaining a safe, harmonious and orderly environment conducive to education and learning. The decision regarding the most effective form of discipline in a particular instance should therefore be determined by the context of the situation. For example, it depends on the seriousness of the misconduct, the attitude of the learners (e.g. was it as a result of intent or negligence?, the age of the learner, the influence it had on the teaching-learning environment, et cetera.

  11. Mapping climatic mechanisms likely to favour the emergence of novel communities

    Science.gov (United States)

    Ordonez, Alejandro; Williams, John W.; Svenning, Jens-Christian

    2016-12-01

    Climatic conditions are changing at different rates and in different directions, potentially causing the emergence of novel species assemblages. Here we identify areas where recent (1901-2013) changes in temperature and precipitation are likely to be producing novel species assemblages through three distinct mechanisms: emergence of novel climatic combinations, rapid displacement of climatic isoclines and local divergences between temperature and precipitation vectors. Novel climates appear in the tropics, while displacement is faster at higher latitudes and divergence is high in the subtropics and mountainous regions. Globally, novel climate combinations so far are rare (3.4% of evaluated cells), mean displacement is 3.7 km decade-1 and divergence is high (>60°) for 67% of evaluated cells. Via at least one of the proposed mechanisms, novel species assemblages are likely to be forming in the North American Great Plains and temperate forests, Amazon, South American grasslands, Australia, boreal Asia and Africa. In these areas, temperature- and moisture-sensitive species may be affected by new climates emerging, differential biotic lags to rapidly changing climates or by being pulled in opposite directions along local spatial gradients. These results provide spatially explicit hypotheses about where and why novel communities are likely to emerge due to recent climate change.

  12. Off-farm employment and income poverty in favourable agro-climatic areas of Tanzania

    DEFF Research Database (Denmark)

    Msinde, John Victor; Urassa, Justin K.; Nathan, Iben

    2016-01-01

    in the first quarter of 2014 in five villages of Kilombero Valley, Tanzania using a structured questionnaire. Income poverty was analysed using the Foster-Greer-Thorbecke (FGT) poverty index and two stage least square (2SLS) regression. Households with off-farm employment income were found to be less poor...

  13. Factors favouring large organic production in the northern Adriatic: towards the northern Adriatic empirical ecological model

    Directory of Open Access Journals (Sweden)

    R. Kraus

    2015-06-01

    Full Text Available Influenced by one of the largest Mediterranean rivers, Po, the northern Adriatic production is highly variable seasonally and interannually. The changes are especially pronounced between winters and seemingly reflect on total Adriatic bioproduction of certain species (anchovy. We analysed the long-term changes in the phytoplankton production at the transect in the region, as derived from monthly oceanographic cruises, in relation to concomitant geostrophic currents distribution in the area and in the Po River discharge rates in days preceding the cruises. In winter and early spring the phyto-abundances depended on existing circulation fields, in summer and autumn they were related to 1–15 days earlier Po River discharge rates and on concomitant circulation fields, while in late spring phyto-abundances increased 1–3 days after high Po River discharge rates regardless of circulation fields. During the entire year the phyto-abundances were dependant on forcing of the previous 1–12 months of surface fluxes and/or Po River rates. Large February blooms are, as well as February circulation patterns, precondited by low evaporation rates in previous November. From 1990 to 2004 a shift towards large winter bioproduction induced by circulation changes appeared. Performed investigations represent the preliminary actions in building of an empirical ecological model of the northern Adriatic which can be used in the sustainable economy of the region, however also in validation of the numerical ecological model of the region, which is currently being developed.

  14. Sepsis and 'superbugs': should we favour the transperineal over the transrectal approach for prostate biopsy?

    Science.gov (United States)

    Grummet, Jeremy P; Weerakoon, Mahesha; Huang, Sean; Lawrentschuk, Nathan; Frydenberg, Mark; Moon, Daniel A; O'Reilly, Mary; Murphy, Declan

    2014-09-01

    To determine the rate of hospital re-admission for sepsis after transperineal (TP) biopsy using both local data and worldwide literature, as there is growing interest in TP biopsy as an alternative to transrectal ultrasonography (TRUS)-guided biopsy for patients undergoing repeat prostate biopsy. Pooled prospective databases on TP biopsy from multiple centres in Melbourne were queried for rates of re-admission for infection. A literature review of PubMed and Embase was also conducted using the search terms: 'prostate biopsy, fever, infection, sepsis, septicaemia and complications'. In all, 245 TP biopsies were performed (111 at Alfred Health, 92 at Epworth Healthcare, 38 at Peter MacCallum Cancer Centre, and four at other institutions). The rate of hospital re-admission for infection was zero. The literature review showed that the rate of sepsis after TRUS biopsy appears to be rising with increasing rates of multi-resistant bacteria found in rectal flora, and is as high as 5%. However, the rate of sepsis from published series of TP biopsy approached zero. Both local and international data suggest a negligible rate of sepsis with TP biopsy. This compares to a concerning rise in the rate of sepsis after TRUS biopsy due to the increasing prevalence of multi-resistant bacteria in rectal flora. Although TRUS biopsy is convenient, cheap and quick to perform, we think that TP biopsy should now be offered as an option, not only to patients undergoing repeat prostate biopsy, but to all patients in whom a prostate biopsy is indicated. © 2013 The Authors. BJU International © 2013 BJU International.

  15. Migrating swans profit from favourable changes in wind conditions at low altitude

    NARCIS (Netherlands)

    Klaassen, M.R.J.; Beekman, J.H.; Kontiokorpi, J.; Mulder, R.J.W.; Nolet, B.A.

    2004-01-01

    Because energy reserves limit flight range, wind assistance may be of crucial importance for migratory birds. We tracked eight Bewicks swans Cygnus columbianus bewickii, using 95-g satellite transmitters with altimeters and activity sensors, during their spring migration from Denmark to northern

  16. Migrating swans profit from favourable changes in wind conditions at low altitude

    NARCIS (Netherlands)

    Klaassen, M; Beekman, JH; Kontiokorpi, J; Mulder, RJW; Nolet, BA

    Because energy reserves limit flight range, wind assistance may be of crucial importance for migratory birds. We tracked eight Bewick's swans Cygnus columbianus bewickii, using 95-g satellite transmitters with altimeters and activity sensors, during their spring migration from Denmark to northern

  17. Analysis of a recent experiment seemingly favouring local realism against quantum mechanics

    Science.gov (United States)

    Santos, E.

    2008-03-01

    A recent experiment by Brida et al. [Eur. Phys. J. D 44, 547 (2007)] is analyzed with the conclusion that the results disagree with standard quantum predictions but fit a simple local hidden variables model. New experiments are proposed which might throw new light on the anomaly.

  18. Severe acute haemorrhagic liver failure in a neonate with a favourable spontaneous outcome

    Energy Technology Data Exchange (ETDEWEB)

    Cavet, Madeleine; Balu, Marie; Garel, Catherine; Ducou le Pointe, Hubert [Universite Pierre et Marie Curie Paris VI, Service de Radiologie, Hopital d' enfants Armand-Trousseau, Paris (France); Mitanchez, Delphine; Alexandre, Marie [Universite Pierre et Marie Curie Paris VI, Service de Neonatologie, Hopital d' enfants Armand-Trousseau, Paris (France); Renolleau, Sylvain [Universite Pierre et Marie Curie Paris VI, Service de Reanimation, Hopital d' enfants Armand-Trousseau, Paris (France); Pariente, Daniele [Hopital de Bicetre, Service de Radiologie Pediatrique, Paris (France)

    2008-10-15

    Acute liver failure in neonates is rare and is frequently associated with an unfavourable outcome. There is no curative treatment other than liver transplantation. Screening for viral, metabolic, toxic or vascular disease is essential to assess the prognosis and to guide specific treatment. Hepatic haemorrhage in neonates is often associated with bacterial infection, trauma and coagulopathies. We present a unique case of neonatal acute liver failure and multifocal massive haemorrhagic intrahepatic lesions of traumatic origin, documented by US and MRI. The patient made a spontaneous recovery. Clinical, biological and imaging outcome was excellent despite the apparent severity of the initial features. The only possible aetiology was a difficult caesarean delivery for mild fetal macrosomia. (orig.)

  19. Progressive multifocal leucoencephalopathy in an immunocompetent patient with favourable outcome. A case report

    Directory of Open Access Journals (Sweden)

    Mørk Sverre J

    2010-05-01

    Full Text Available Abstract Background To report the clinical course of PML in an apparently immunocompetent patient treated with cidofovir. Case Presentation A 35-year-old immunocompetent man who developed progressive hemianopsia, aphasia, and limb weakness underwent repeated MRI scans of the brain, spinal fluid analyses, and brain biopsy. Before diagnosis was established based on brain biopsy, he was consecutively treated with methylprednisolone, acyclovir, ceftriaxone and plasmapheresis, but he deteriorated rapidly suggestive of the immune reconstitution inflammatory syndrome (IRIS. He started to recover two weeks after the initiation of treatment with cidofovir and has had no relapse at 3 1/2 years of follow-up. MRI has shown marked improvement. Conclusions PML should be considered in immunocompetent patients with a typical clinical course and MRI findings compatible with PML. Treatment with cidofovir should be considered as early as possible in the disease course.

  20. Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases

    DEFF Research Database (Denmark)

    Häusler, M; Kluger, G; Nikanorova, M

    2011-01-01

    Epilepsy with myoclonic absences (EMA) is a rare epileptic syndrome with frequently poor response to antiepileptic treatment. Rufinamide (RUF) is a relatively new EMEA- and FDA-approved anticonvulsant licensed as an orphan drug for the adjunctive treatment of patients with Lennox-Gastaut syndrome....

  1. Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke

    NARCIS (Netherlands)

    Uyttenboogaart, Maarten; Koch, Marcus W; Stewart, Roy E; Vroomen, Patrick C; Luijckx, Gert-Jan; De Keyser, Jacques

    Hyperglycaemia in acute ischaemic stroke is traditionally associated with a worsened outcome. However, it is unclear whether the impact of hyperglycaemia on stroke outcome is similar in lacunar and non-lacunar infarctions. The relation between serum glucose measured within 6 h after stroke onset and

  2. Migrating swans profit from favourable changes in wind conditions at low altitude

    NARCIS (Netherlands)

    Klaassen, M.R.J.; Beekman, J.H.; Kontiokorpi, J.; Mulder, R.J.W.; Nolet, B.A.

    2004-01-01

    Because energy reserves limit flight range, wind assistance may be of crucial importance for migratory birds. We tracked eight Bewicks swans Cygnus columbianus bewickii, using 95-g satellite transmitters with altimeters and activity sensors, during their spring migration from Denmark to northern Rus

  3. Migrating swans profit from favourable changes in wind conditions at low altitude

    NARCIS (Netherlands)

    Klaassen, M; Beekman, JH; Kontiokorpi, J; Mulder, RJW; Nolet, BA

    2004-01-01

    Because energy reserves limit flight range, wind assistance may be of crucial importance for migratory birds. We tracked eight Bewick's swans Cygnus columbianus bewickii, using 95-g satellite transmitters with altimeters and activity sensors, during their spring migration from Denmark to northern Ru

  4. Evidence for maternally inherited factors favouring male homosexuality and promoting female fecundity.

    OpenAIRE

    Camperio-Ciani, Andrea; Corna, Francesca; Capiluppi, Claudio

    2004-01-01

    The Darwinian paradox of male homosexuality in humans is examined, i.e. if male homosexuality has a genetic component and homosexuals reproduce less than heterosexuals, then why is this trait maintained in the population? In a sample of 98 homosexual and 100 heterosexual men and their relatives (a total of over 4600 individuals), we found that female maternal relatives of homosexuals have higher fecundity than female maternal relatives of heterosexuals and that this difference is not found in...

  5. Reward favours the prepared: incentive and task-informative cues interact to enhance attentional control

    Science.gov (United States)

    Chiew, Kimberly S.; Braver, Todd S.

    2015-01-01

    The dual mechanisms of control account suggests that cognitive control may be implemented through relatively proactive mechanisms in anticipation of stimulus onset, or through reactive mechanisms, triggered in response to changing stimulus demands. Reward incentives and task-informative cues (signaling the presence/absence of upcoming cognitive demand) have both been found to influence cognitive control in a proactive or preparatory fashion; yet, it is currently unclear whether and how such cue effects interact. We investigated this in two experiments using an adapted flanker paradigm, where task-informative and reward incentive cues were orthogonally manipulated on a trial-by-trial basis. In Experiment 1, results indicated that incentives not only speed RTs, but specifically reduce both interference and facilitation effects when combined with task-informative cues, suggesting enhanced proactive attentional control. Experiment 2 manipulated the timing of incentive cue information, demonstrating that such proactive control effects were only replicated with sufficient time to process the incentive cue (Early Incentive); when incentive signals were presented close to target onset (Late Incentive) the primary effect was a speed-accuracy tradeoff. Together, results suggest that advance cueing may trigger differing control strategies, and that these strategies may critically depend on both the timing – and the motivational incentive – to use such cues. PMID:26322689

  6. MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours

    KAUST Repository

    Perlman, Elizabeth J.

    2015-12-04

    Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genomic changes responsible for the development of the majority of Wilms tumours remain largely unknown. Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. The mutant MLLT1 protein shows altered binding to acetylated histone tails. Moreover, MLLT1-mutant tumours show an increase in MYC gene expression and HOX dysregulation. Patients with MLLT1-mutant tumours present at a younger age and have a high prevalence of precursor intralobar nephrogenic rests. These data support a model whereby activating MLLT1 mutations early in renal development result in the development of Wilms tumour.

  7. Maternal anxiety predicts favourable treatment outcomes in anxiety-disordered adolescents

    NARCIS (Netherlands)

    Legerstee, J.S.; Huizink, A.C.; Gastel, W. van; Liber, J.M.; Treffers, P.D.A.; Verhulst, F.C.; Utens, E.M.W.J.

    2008-01-01

    Objective: To determine the differential impact of maternal and paternal internalizing psychopathology on cognitive-behavioural treatment (CBT) outcome of anxiety-disordered children and adolescents. Method: Participants consisted of 127 children and 51 adolescents with a primary anxiety diagnosis.

  8. The evolution of sex is favoured during adaptation to new environments.

    Science.gov (United States)

    Becks, Lutz; Agrawal, Aneil F

    2012-01-01

    Both theory and experiments have demonstrated that sex can facilitate adaptation, potentially yielding a group-level advantage to sex. However, it is unclear whether this process can help solve the more difficult problem of the maintenance of sex within populations. Using experimental populations of the facultatively sexual rotifer Brachionus calyciflorus, we show that rates of sex evolve to higher levels during adaptation but then decline as fitness plateaus. To assess the fitness consequences of genetic mixing, we directly compare the fitnesses of sexually and asexually derived genotypes that naturally occur in our experimental populations. Sexually derived genotypes are more fit than asexually derived genotypes when adaptive pressures are strong, but this pattern reverses as the pace of adaptation slows, matching the pattern of evolutionary change in the rate of sex. These fitness assays test the net effect of sex but cannot be used to disentangle whether selection on sex arises because highly sexual lineages become associated with different allele combinations or with different allele frequencies than less sexual lineages (i.e., "short-" or "long-term" effects, respectively). We infer which of these mechanisms provides an advantage to sex by performing additional manipulations to obtain fitness distributions of sexual and asexual progeny arrays from unbiased parents (rather than from naturally occurring, and thereby evolutionarily biased, parents). We find evidence that sex breaks down adaptive gene combinations, resulting in lower average fitness of sexual progeny (i.e., a short-term disadvantage to sex). As predicted by theory, the advantage to sex arises because sexually derived progeny are more variable in fitness, allowing for faster adaptation. This "long-term advantage" builds over multiple generations, eventually resulting in higher fitness of sexual types.

  9. Factors favouring large organic production in the northern Adriatic: towards the northern Adriatic empirical ecological model

    Science.gov (United States)

    Kraus, R.; Supić, N.; Precali, R.

    2015-06-01

    Influenced by one of the largest Mediterranean rivers, Po, the northern Adriatic production is highly variable seasonally and interannually. The changes are especially pronounced between winters and seemingly reflect on total Adriatic bioproduction of certain species (anchovy). We analysed the long-term changes in the phytoplankton production at the transect in the region, as derived from monthly oceanographic cruises, in relation to concomitant geostrophic currents distribution in the area and in the Po River discharge rates in days preceding the cruises. In winter and early spring the phyto-abundances depended on existing circulation fields, in summer and autumn they were related to 1-15 days earlier Po River discharge rates and on concomitant circulation fields, while in late spring phyto-abundances increased 1-3 days after high Po River discharge rates regardless of circulation fields. During the entire year the phyto-abundances were dependant on forcing of the previous 1-12 months of surface fluxes and/or Po River rates. Large February blooms are, as well as February circulation patterns, precondited by low evaporation rates in previous November. From 1990 to 2004 a shift towards large winter bioproduction induced by circulation changes appeared. Performed investigations represent the preliminary actions in building of an empirical ecological model of the northern Adriatic which can be used in the sustainable economy of the region, however also in validation of the numerical ecological model of the region, which is currently being developed.

  10. Deep Impact Mission to Tempel 1 Favours New Explosive Cosmogony of Comets

    CERN Document Server

    Drobyshevski, E M; Schmidt, A A

    2006-01-01

    The assumption that short-period (SP) comets are fragments of massive icy envelopes of Ganymede-like bodies saturated by products of ice electrolysis that underwent global explosions provides a plausible explanation of all known manifestations of comets, including the jet character of outflows, the presence of ions in the vicinity of the nucleus, the bursts and splitting of cometary nuclei, etc., with solar radiation initiating burning of the products of electrolysis in the nucleus. As shown persuasively by numerical simulation carried out in hydrodynamic approximation, the shock wave initiated by the Deep Impact (DI) impactor in the cometary ice saturated originally by the electrolysis products 2H2 + O2 is capable of activating under certain conditions exothermal reactions (of the type O2 + H2 + organics = H2O + CO + HCN + other products of incomplete burning of organics including its light and heavy pyrolyzed compounds, soot, etc.), which will slow down shock wave damping (forced detonation) and increase ma...

  11. Favourable prognostic features in histiocytosis X: bone involvement and absence of skin disease.

    OpenAIRE

    Broadbent, V

    1986-01-01

    The records of 70 patients presenting to this hospital since 1961 with histiocytosis X confirmed by biopsy examination have been reviewed. The patients were subdivided into three groups: group A, those under 2 years of age at diagnosis; group B, those between 2 and 5 years; and group C, those over 5 years. All eight patients who died (11% overall mortality) were under 2 years of age at diagnosis. Involvement of lung, liver, and bone marrow were confirmed as poor prognostic features. The prese...

  12. Ethics and Vulnerability in Street Prostitution; An Argument in Favour of Managed Zones

    Directory of Open Access Journals (Sweden)

    Anna Carline

    2009-03-01

    Full Text Available This article draws upon the work of Judith Butler, in particular her approach to ethics and the concepts of vulnerability and „liveable lives,‟ in order to provide a critical analysis of reform proposals contained in the Criminal Justice and Immigration Bill (now Act 2008 in relation to street prostitution. The article will argue that the proposals presented in the Bill problematically use the vulnerability of street sex workers in order to promote a moralistic agenda. In contrast it will be argued that managed zones, as proposed by Liverpool City Council, provide a potentially more ethical approach to the issue of street prostitution.

  13. Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion.

    Directory of Open Access Journals (Sweden)

    Alain Mechulam

    2009-01-01

    Full Text Available We suggest for the first time that the action of multivalent cations on microtubule dynamics can result from facilitated diffusion of GTP-tubulin to the microtubule ends. Facilitated diffusion can promote microtubule assembly, because, upon encountering a growing nucleus or the microtubule wall, random GTP-tubulin sliding on their surfaces will increase the probability of association to the target sites (nucleation sites or MT ends. This is an original explanation for understanding the apparent discrepancy between the high rate of microtubule elongation and the low rate of tubulin association at the microtubule ends in the viscous cytoplasm. The mechanism of facilitated diffusion requires an attraction force between two tubulins, which can result from the sharing of multivalent counterions. Natural polyamines (putrescine, spermidine, and spermine are present in all living cells and are potent agents to trigger tubulin self-attraction. By using an analytical model, we analyze the implication of facilitated diffusion mediated by polyamines on nucleation and elongation of microtubules. In vitro experiments using pure tubulin indicate that the promotion of microtubule assembly by polyamines is typical of facilitated diffusion. The results presented here show that polyamines can be of particular importance for the regulation of the microtubule network in vivo and provide the basis for further investigations into the effects of facilitated diffusion on cytoskeleton dynamics.

  14. A Note on Profile Likelihood, Least Favourable Families and Kullback-Leibler Distance.

    Science.gov (United States)

    1988-04-19

    N.Y. Skovgard, I. M. (1985). A second order investigation of asymptotic ancillarity. Ann. q Statist., 13, 534-551. Spivak , M. (1965). Calculus on...First note that c(t) is differentiable by the implicit function theorem ( Spivak , 1965, p. 41). Now, since c(t) is defined as a minimum we have

  15. Did the price-related reforms in Ghana's cocoa sector favour farmers?

    NARCIS (Netherlands)

    Quarmine, W.; Haagsma, R.; Huis, van A.; Sakyi-Dawson, O.; Obeng-Ofori, D.; Asante, F.

    2014-01-01

    It is generally hypothesized in the innovation systems literature that institutions can create production incentives for farmers. This paper examines whether the introduction in 1984 of the Producer Price Review Committee (PPRC) in Ghana's cocoa sector has improved the transmission of world prices

  16. Telling Another Story of Europe: A Reply in Favour of Politics

    Directory of Open Access Journals (Sweden)

    Luuk van Middelaar

    2010-01-01

    Full Text Available Middelaar, Luuk van, De passage naar Europa. Geschiedenis van een begin (Dissertatie Universiteit van Amsterdam 2009; Groningen: Historische Uitgeverij, 2009, 531 blz., ISBN 978 90 6554 236 6.All three discussiants note the rich use of language in De passage naar Europa, but without linking it to the book’s discourse analysis or its alleged scarcity of social science. Words are not innocent, however; in political battles, even theoretical concepts are constantly being co-opted. To escape from existing connotations, we can either examine a vocabulary’s use (a well-known practice in intellectual history, or introduce new words (as I do with ‘passage’ or ‘sphere’. For good reason, history, political philosophy and law are the disciplines chosen to tell this story of Europe. The focus is neither on the Brussels institutions, nor just on Member States and national interests. Rather, it is the story of the ensemble of European states trying to become the political expression of the continent: of its birth and metamorphoses, its efforts to fill a space and find a voice.

  17. VLBI-Gaia offsets favour parsec-scale jet direction in Active Galactic Nuclei

    CERN Document Server

    Kovalev, Y Y; Plavin, A V

    2016-01-01

    The data release 1 (DR1) of milliarcsecond-scale accurate optical positions of stars and galaxies was recently published by the space mission Gaia. We analyze the offsets of highly accurate absolute radio (very long baseline interferometry, VLBI) and optical positions of active galactic nuclei (AGN) to check whether a signature of wavelength-dependent parsec-scale structure can be seen. We use in the analysis astrometric positions of thousands of AGNs from the VLBI and Gaia observations as well as reconstructed VLBI images. We have found that there is a statistically significant excess of sources with VLBI-to-Gaia positional offset directions along the jet for a full range of offset values as well as an excess for the direction opposite to the jet if offset values are less than 3 mas. An existence of strong extended parsec-scale optical jet structure in many AGNs is required to explain the observed VLBI-Gaia offsets along the jet direction. The 1-mas offsets in the opposite direction are explained by a non-po...

  18. Life-history trade-offs favour the evolution of animal personalities

    NARCIS (Netherlands)

    Wolf, M.; Van Doorn, G.S.; Leimar, O.; Weissing, F.J.

    2007-01-01

    In recent years evidence has been accumulating that personalities are not only found in humans(1) but also in a wide range of other animal species(2-8). Individuals differ consistently in their behavioural tendencies and the behaviour in one context is correlated with the behaviour in multiple other

  19. Life history differences favour evolution of male dimorphism in competitive games

    NARCIS (Netherlands)

    Smallegange, I.M.; Johansson, J.

    2014-01-01

    Many species exhibit two discrete male morphs: fighters and sneakers. Fighters are large and possess weapons but may mature slowly. Sneakers are small and have no weapons but can sneak matings and may mature quickly to start mating earlier in life than fighters. However, how differences in competiti

  20. Supernova remnant energetics and magnetars: no evidence in favour of millisecond proto-neutron stars

    NARCIS (Netherlands)

    Vink, J.; Kuiper, L.

    2006-01-01

    It is generally accepted that anomalous X-ray pulsars (AXPs) and soft gamma-ray repeaters (SGRs) are magnetars, i.e. neutron stars with extremely high surface magnetic fields (B > 1014 G). The origin of these high magnetic fields is uncertain, but a popular hypothesis is that magnetars are born with

  1. Favouring New Indigenous Leadership: Indigenous Students Attending Higher Education in Mexico

    Science.gov (United States)

    Delgado, Manuel Lopez

    2016-01-01

    The opportunities to attend higher education in Mexico have traditionally been offered to the middle class population since around 30% of students who finish high school are able to attend higher education. The main reason for this low attendance is the poverty in which much of the population lives and the lack of higher education institutions in…

  2. Does Classroom Explicitation of Initial Conceptions Favour Conceptual Change or Is It Counter-Productive?

    Science.gov (United States)

    Potvin, Patrice; Mercier, Julien; Charland, Patrick; Riopel, Martin

    2012-01-01

    This research investigates the effect of classroom explicitation of initial conceptions (CEIC) on conceptual change in the context of learning electricity. Eight hundred and seventy five thirteen year-olds were tested in laboratory conditions to see if CEIC is or is not a productive step toward conceptual change. All students experienced a…

  3. MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours | Office of Cancer Genomics

    Science.gov (United States)

    Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genomic changes responsible for the development of the majority of Wilms tumours remain largely unknown. Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. The mutant MLLT1 protein shows altered binding to acetylated histone tails.

  4. An appeal to humanity: legal victory in favour of North America's only supervised injection facility: Insite.

    Science.gov (United States)

    Small, Dan

    2010-10-09

    Canada's federal government has once again failed to shut North America's only authorized supervised injection facility: Insite. A majority ruling issued by the BC Court of Appeal on 15 January 2010 upheld an earlier British Columbia Supreme Court ruling in 2008 that protected the rights of injection drug users (IDUs) to access Insite as a health facility as per the Charter of Rights and Freedoms component of the Constitution of Canada. The majority decision from Honourable Madam Justices Rowles, Huddart and Smith also established a jurisdictional victory safeguarding Insite as most appropriately run under the authority of the province of British Columbia rather than the federal Government of Canada. The Federal Government has appealed the case to the Supreme Court of Canada. A hearing date has been set for 12 May 2011. The appeal will be a legal one but even more so, it will be an appeal to humanity.

  5. An appeal to humanity: legal victory in favour of North America's only supervised injection facility: Insite

    Directory of Open Access Journals (Sweden)

    Small Dan

    2010-10-01

    Full Text Available Abstract Canada's federal government has once again failed to shut North America's only authorized supervised injection facility: Insite. A majority ruling issued by the BC Court of Appeal on 15 January 2010 upheld an earlier British Columbia Supreme Court ruling in 2008 that protected the rights of injection drug users (IDUs to access Insite as a health facility as per the Charter of Rights and Freedoms component of the Constitution of Canada. The majority decision from Honourable Madam Justices Rowles, Huddart and Smith also established a jurisdictional victory safeguarding Insite as most appropriately run under the authority of the province of British Columbia rather than the federal Government of Canada. The Federal Government has appealed the case to the Supreme Court of Canada. A hearing date has been set for 12 May 2011. The appeal will be a legal one but even more so, it will be an appeal to humanity.

  6. Intestinal Radiation-Induced Stricture Favours Small Bowel Obstruction by Phytobezoar: Report of a Case

    Directory of Open Access Journals (Sweden)

    Alessandra Quercioli

    2009-01-01

    Full Text Available Bezoars represent the fifth most frequent cause of acute small bowel obstruction. Phytobezoar is the most common type of bezoar. It is a concretion of undigestible fibers derived from ingested vegetables and fruits. We report a case of a woman with a 1-year history of recurrent epigastric and periumbilical abdominal pain with intermittent vomiting caused by phytobezoar of the terminal ileum. After careful investigation of the case and review of literature, we identified the factor involved in bezoar formation as radiation-induced ileal stenosis due to previous treatment for a pelvic tumour. This report provides evidence to consider phytobezoar as a possible cause of small bowel obstruction in patients previously treated with abdominal radiotherapy.

  7. Rh sensitized pregnancy with high ICT titre with favourable foetal outcome: a rare case

    Directory of Open Access Journals (Sweden)

    Namrata Saxena

    2015-10-01

    Full Text Available Leiomyosarcoma Rhesus (Rh isoimmunization is the development of maternal IgG antibodies against fetal Rh Red Blood Cell (RBC antigens. Transplacental passage of maternal Rh antibody (IgG anti-D may result in Hemolytic Disease of the Newborn (HDN, a condition characterized by hemolysis, severe fetal anemia and generalized fetal edema (hydrops fetalis. The severity of Rh hemolytic disease may be assessed in the Immunized patient by several different means which include: past obstetric history, maternal antibody titer, ultrasonography, amniotic fluid bilirubin quantification, and percutaneous umbilical blood sampling. A past history of fetal demise, hydrops fetalis, intrauterine transfusion or neonatal exchange transfusion implies that the present pregnancy is or will be severely affected because Rh disease effects on the fetus generally recur or present progressively earlier or more severely with each successive Rh positive pregnancy. We present here a rare case of Rh sensitized pregnancy with high ICT titre who had normal fetal outcome. [Int J Reprod Contracept Obstet Gynecol 2015; 4(5.000: 1574-1576

  8. Arguments in favour and against a code of ethics for historians

    NARCIS (Netherlands)

    De Baets, A.

    2005-01-01

    Traditional attitudes of historians towards professional ethics are laconic. Should they encourage the drafting of codes that explicitly detail ethical principles? I look into the advantages and disadvantages of such professional codes. A first question that arises is whether allied branches of scho

  9. No Magic Solution: An examination of the arguments in favour of contracting out government services

    Directory of Open Access Journals (Sweden)

    Joey O'Brien

    2011-04-01

    Full Text Available

    This paper examines the arguments commonly used to support contracting out service delivery to the private sector and attempts to demonstrate that these arguments overestimate the benefits of contracting out.  First, the economic savings attributed to contracting out service delivery are considered and shown to omit important supplementary costs associated with the contracting process. Next empirical evidence is used to test the common argument that private sector service delivery is always superior to that of the public sector. Finally, the assertion that contracting out service delivery will lead to innovative solutions to government’s problems is explored. The paper attempts to demonstrate that internal reforms of government structures should be considered as a strong alternative option to contracting out.   

  10. A severe genotype with favourable outcome in very long chain acyl-CoA dehydrogenase deficiency

    DEFF Research Database (Denmark)

    Touma, E H; Rashed, M S; Vianey-Saban, C

    2001-01-01

    A patient with very long chain acyl-CoA dehydrogenase (VLCAD) deficiency is reported. He had a severe neonatal presentation and cardiomyopathy. He was found to be homozygous for a severe mutation with no residual enzyme activity. Tandem mass spectrometry on dried blood spots revealed increased lo...... chain acylcarnitines. VLCAD enzyme activity was severely decreased to 2% of control levels. Dietary management consisted of skimmed milk supplemented with medium chain triglycerides and L-carnitine. Outcome was good and there was no acute recurrence....

  11. The divine favour of the unworthy: When the Fatherless Son meets ...

    African Journals Online (AJOL)

    Test

    2011-06-07

    Jun 7, 2011 ... email: boesak@mweb.co.za. Postal address: Postnet Suite 285, Private ... in South Africa, where the cause of the fatherless Jesus has been so shamefully betrayed and ..... of rule by fear through intimidation and terror.

  12. Fortune Favours the Bold: An Agent-Based Model Reveals Adaptive Advantages of Overconfidence in War

    Science.gov (United States)

    Johnson, Dominic D. P.; Weidmann, Nils B.; Cederman, Lars-Erik

    2011-01-01

    Overconfidence has long been considered a cause of war. Like other decision-making biases, overconfidence seems detrimental because it increases the frequency and costs of fighting. However, evolutionary biologists have proposed that overconfidence may also confer adaptive advantages: increasing ambition, resolve, persistence, bluffing opponents, and winning net payoffs from risky opportunities despite occasional failures. We report the results of an agent-based model of inter-state conflict, which allows us to evaluate the performance of different strategies in competition with each other. Counter-intuitively, we find that overconfident states predominate in the population at the expense of unbiased or underconfident states. Overconfident states win because: (1) they are more likely to accumulate resources from frequent attempts at conquest; (2) they are more likely to gang up on weak states, forcing victims to split their defences; and (3) when the decision threshold for attacking requires an overwhelming asymmetry of power, unbiased and underconfident states shirk many conflicts they are actually likely to win. These “adaptive advantages” of overconfidence may, via selection effects, learning, or evolved psychology, have spread and become entrenched among modern states, organizations and decision-makers. This would help to explain the frequent association of overconfidence and war, even if it no longer brings benefits today. PMID:21731627

  13. Primary gastric Hodgkin's lymphoma: favourable outcome following multi-agent chemotherapy without surgical intervention.

    LENUS (Irish Health Repository)

    Quintyne, K I

    2011-02-01

    The authors report the case of a 51-year-old man who presented with left-sided abdominal pain and weight loss associated with drenching night sweats. Preliminary blood tests yielded no specific cause for his symptoms, but abdominal ultrasound revealed multiple hepatic lesions and peripancreatic lymphadenopathy. Further imaging, including positron emission tomography (PET)\\/CT, revealed fludeoxyglucose 18F (FDG) avid uptake within lymphadenopathy above and below the diaphragm and also noted gastric thickening. Diagnosis was established with gastric biopsy and revealed gastric Hodgkin\\'s lymphoma. He was started on and tolerated multi-agent chemotherapy. Repeated PET\\/CT and gastric biopsy showed complete metabolic and pathologic response to treatment.

  14. Intrasexual selection favours an immune-correlated colour ornament in a dragonfly.

    Science.gov (United States)

    Moore, M P; Martin, R A

    2016-11-01

    Sexual signalling is predicted to shape the evolution of sex-specific ornamentation, and establishing the costs and benefits of ornamentation and the information that ornamentation provides to receivers is necessary to evaluating this adaptive function. Here, we assessed the adaptive function of a common colour ornament in insects, melanin wing ornamentation, using the dragonfly Pachydiplax longipennis. We hypothesized that greater ornamentation would improve territory-holding success by decreasing aggression that males receive from territorial rivals, but that more ornamented males may have shorter lifespans. Using mark-recapture field observations, we found that more ornamented males had greater territory-holding success and that viability selection did not act on wing melanization. We then compared the aggression of territorial rivals to decoy males before and after experimentally augmenting wing melanization, finding that males significantly reduced aggression following the manipulation. We next hypothesized that wing melanization would signal fighting ability to territorial rivals by reflecting condition via investment in the costly melanin synthesis pathway. We observed a positive relationship between ornamentation and the likelihood of winning territorial disputes, suggesting that wing melanization provides information about fighting ability to rivals. We also found a positive relationship between melanin-based immune defence and ornamentation, supporting a link between the signal and condition. We conclude that wing melanization is a condition-related signal of fighting ability and suggest that this may be a common mechanism promoting the evolution of melanin ornamentation.

  15. Environmental gradient favours functionally diverse macrobenthic community in a placer rich tropical bay

    Digital Repository Service at National Institute of Oceanography (India)

    Sivadas, S.K.; Ingole, B.S.; Fernandes, C.E.G.

    (GR), omnivore (O), and carnivore (C). Mobility categories included: mobile (M), discretely mobile (D), and sessile (S). Five categories of habit type were classified free living, that is, living on surface or actively burrowing (F), tubiculous (T... Polychaeta Ancistrosyllis sp. 0–25 C M F Microphthalmus sp. 0–1,100 GR M F Hesione sp. 0–50 O M F Exogone sp. 25–75 GR M F Odontosyllis sp. 0–50 C M F Nereis sp. 25–75 O D T Perinereis sp. 0–25 O D T Eteone sp. 50–1,025 O M F Phyllodoce sp. 50–650 O M F...

  16. The Favourable Choice of the Shape of Billet's Contact Surface to Quality of Extruded Aluminium Profiles

    Directory of Open Access Journals (Sweden)

    G. Skorulski

    2010-07-01

    Full Text Available The theoretical and experimental method of optimization the aluminium billet’s contact surface during extrusion have been presented inthis paper. The theoretical assumption, based on welding criteria, have been confirmed by experimental researches. The technique ofmeasurement has been shown as well. Experiments are made using plasticine as a substiute material. Some kind of different variants have been investigated. The theory and experiments have been provided to optimize the modeling shape and may help in design and technology.The theory has been tested experimentally using a plasticine as a substitute material and a plexiglass die such that the velocity fields at the surfaces could be observed and measured during plastic flow, allowing the empirical coefficients in the mathematical formulation to be estimated. On the basis of the theory and experiments an optimal billet’s contact surface was proposed.

  17. Does Mental Health Status Influence Susceptibility to the Physiologic Effects of Air Pollution? A Population Based Study of Canadian Children

    OpenAIRE

    Dales, Robert E; Cakmak, Sabit

    2016-01-01

    Background Both air pollution exposure and the presence of mental illness are associated with an increased risk of physical illness. Objective To determine whether or not children with less favourable mental health are more susceptible to pulmonary and cardiovascular effects of ambient air pollution, compared to those who are mentally healthy. Methods We carried out a cross-sectional study of 1,883 children between the ages of 6 and 17 years of age who participated in the Canadian Health Meas...

  18. A study of the centrally produced $\\phi \\phi$ system in pp interactions at 450 GeV/c

    CERN Document Server

    Barberis, D

    1998-01-01

    The reaction pp to pfps(K+K-K+K-) in which the K+K-K+K- system is centrally produced has been studied at 450 GeV/c. Phi phi production has been found to dominate this reaction and is compatible with being produced by double Pomeron exchange. An angular analysis of the phi phi system favours JPC = 2++ and its dPT dependence is similar to that observed for glueball candidates.

  19. The Performance and Efficiency of Islamic Banking in South Asian Countries

    Directory of Open Access Journals (Sweden)

    Muhammad IRFAN

    2014-12-01

    Full Text Available The objective of this study is to estimate and analyze the Islamic banks efficiency in South Asian Countries. The study sample consists of four countries i.e. Pakistan, Iran, Brunei and Bangladesh for being similar legal, social and economic framework for Islamic banking systems. Stochastic frontier approach is used to estimate the performance through input and output method for the period of 2004 to 2011. Results demonstrate that Islamic banking is efficient about 98.19% with respect to return on asset ratio; with respect to return on equity ratio is about 91.4% and 77.03% with respect to net profit ratio. As per the efficiency-ranking measurement, Brunei stands at top followed by Pakistan, Iran and Bangladesh among the South Asian countries.

  20. Brunei Media, For the Monarch and Islamic%浸透着伊斯兰文化传统的文莱媒介

    Institute of Scientific and Technical Information of China (English)

    李异平

    2002-01-01

    文莱是个穆斯林君主制和伊斯兰传统的国家.1984年独立后,政府一直依靠集权统治和至高无上的宗教体系来维持原有的意识形态和价值观.媒介,作为意识形态的一个主要部分,自然也被浸透在伊斯兰君主制的思想中,而且在法律的监护下担负着将伊斯兰思想渗透到社会各个阶层的任务.

  1. Quasar Absorption Studies

    Science.gov (United States)

    Mushotzky, Richard (Technical Monitor); Elvis, Martin

    2004-01-01

    The aim of the proposal is to investigate the absorption properties of a sample of inter-mediate redshift quasars. The main goals of the project are: Measure the redshift and the column density of the X-ray absorbers; test the correlation between absorption and redshift suggested by ROSAT and ASCA data; constrain the absorber ionization status and metallicity; constrain the absorber dust content and composition through the comparison between the amount of X-ray absorption and optical dust extinction. Unanticipated low energy cut-offs where discovered in ROSAT spectra of quasars and confirmed by ASCA, BeppoSAX and Chandra. In most cases it was not possible to constrain adequately the redshift of the absorber from the X-ray data alone. Two possibilities remain open: a) absorption at the quasar redshift; and b) intervening absorption. The evidences in favour of intrinsic absorption are all indirect. Sensitive XMM observations can discriminate between these different scenarios. If the absorption is at the quasar redshift we can study whether the quasar environment evolves with the Cosmic time.

  2. Studies on mass transfer in electrochemical systems

    Energy Technology Data Exchange (ETDEWEB)

    Sundstroem, L.G.

    1997-10-01

    The first part is of an introductory nature. It contains a description of the methods used, a discussion of the physics of electrochemical cells with a liquid electrolyte, and a summary of the different studies made, including both those which have been reported in papers, and those which have not. Contributions with novel aspects include (* a derivation of the electro-neutrality condition from Maxwell`s equations of electrodynamics, and **) an argument in favour of the use of mass-averaged velocity in ion transport expressions. The second part focuses on specific cases. It consists of seven research papers which give a more detailed presentation of the main studies 40 refs, 6 figs

  3. A DFT study of CO2 hydrogenation on faujasite supported Ir4 clusters: on the role of water for selectivity control

    OpenAIRE

    2016-01-01

    Abstract Reaction mechanisms for the catalytic hydrogenation of CO2 by faujasite‐supported Ir4 clusters were studied by periodic DFT calculations. The reaction can proceed through two alternative paths. The thermodynamically favoured path results in the reduction of CO2 to CO, whereas the other, kinetically preferred channel involves CO2 hydrogenation to formic acid under water‐free conditions. Both paths are promoted by catalytic amounts of water confined inside the zeolite micropores with a...

  4. LANDSLIDES INCIDENCE IN THE PIEDMONT OF BAIA MARE URBAN AREA (CASE STUDIES

    Directory of Open Access Journals (Sweden)

    S. ZAHARIA

    2012-12-01

    Full Text Available The landslides incidence in the piedmont of baia mare urbana area cae studies. The General Urban Plan (GUP of Baia Mare municipality requires the study of expected susceptibility for landslides in order to build infrastructure within sustainable development conditions. The complexity and diversity of local geographic area factors, strongly affected by the human pressure, favours the triggering and extension of slope processes in the municipality’s piedmont area. To prevent some major imbalances it is imperative to implement some adequate measures based on in-depth studies.

  5. The association between exposure to psychosocial work factors and mental health in older employees, a 3-year follow-up study.

    Science.gov (United States)

    Havermans, Bo M; Boot, Cécile R L; Hoekstra, Trynke; Houtman, Irene L D; Brouwers, Evelien P M; Anema, Johannes R; van der Beek, Allard J

    2017-09-18

    Unfavourable exposure to psychosocial work factors threatens older employees' mental health, and their sustained employment. This study assesses whether an improved compared to stable unfavourable and stable favourable exposure to psychosocial work factors is associated with a change in mental health in older employees at 3-year follow-up. The current study used data from the Study on Transitions in Employment, Ability and Motivation (STREAM), in workers aged 45-65 years (n = 5249). Two-year (2010-2012) exposure was assessed for psychological demands, autonomy, support, mental load, and distributive justice. Linear regression analyses were performed to compare improved exposure to unfavourable psychosocial work factors with stable unfavourable and stable favourable exposure and mental health at follow-up (2013), corrected for confounders. Analyses were stratified for age groups (45-54 and 55-65 years) and gender. In certain subgroups, stable unfavourable exposure to psychological demands, autonomy, support, and distributive justice was associated with a significantly lower mental health score than improved exposure. Stable favourable exposure to support was associated with a higher mental health score than improved support, whereas stable favourable exposure to autonomy was associated with a lower mental health score compared to improved exposure. There is a longitudinal association between changes in exposure to psychosocial work factors and mental health. Improvement in unfavourable exposure to psychosocial work factors was associated with improved mental health. This is important information for organisations that consider deploying measures to improve the psychosocial work environment of older workers.

  6. CO 2 sorption on substituted carbon materials . Computational chemistry studies

    Science.gov (United States)

    Gauden, P. A.; Wiśniewski, M.

    2007-04-01

    Theoretical study of sorption of CO 2 on the 4-ring graphene ("unmodified" or N-, O-, and OH-substituted) structures possessing one completely unsaturated edge zigzag site is reported using the DFT (B3LYP/6-31G(d,p)) method. Lactone and heterocyclic complexes (due to thermodynamic favourability) are taken into account. The analysis of theoretical results shows that the enthalpy of reaction strongly depends on the chemical nature, i.e. the position of the doping of atom(s) is crucial. All substitutions do not change or decrease the enthalpy in comparison with the "unmodified" graphene sheet. The well-known theoretical reactivity indices (ionization potential, electron affinity, global softness, and HOMO-LUMO gaps) are calculated for the studied adsorbents in order to explain the above-mentioned tendencies. Finally, the effect of the presence of heteroatoms on the enthalpy of reaction (Δ H298) for all CO 2-heteroatom-doping adsorbent complexes is shown. Thus, carbon dioxide molecules adsorb on the edge plane surface of N-, O-, OH-containing carbon surfaces similarly or much less favourably in comparison with the "unmodified" adsorbents. This confirms some experimental observations.

  7. Phytochemical study of Cistus libanotis L.

    Science.gov (United States)

    Venditti, Alessandro; Bianco, Armandodoriano; Bruno, Maurizio; Ben Jemia, Mariem; Nicoletti, Marcello

    2015-01-01

    In continuation of our ongoing study on Mediterranean Flora, we focused the attention on Cistus genus. These plants possess interesting secondary metabolites and are used in many fields, principally in perfumery and more recently as raw material for food supplements (botanicals). n this article, we report the phytochemical analysis of Cistus libanotis L. from Tunisia. Among the diterpenes, labdane compounds resulted absent, in favour of two clerodanes, one of that never reported in Cistus sp. The main representative compounds were found to be several flavonoids with various grades of O-methylation. Other interesting components were two cinnamic esters of borneol, reported here for the first time in Cistus. The identified compounds confirm in part the reported biological properties and add chemotaxonomic data to this complicated genus.

  8. When a Bilingual Child Describes Living Things: An Analysis of Conceptual Understandings from a Language Perspective

    Science.gov (United States)

    Salleh, Romaizah; Venville, Grady J.; Treagust, David F.

    2007-07-01

    With increasing numbers of students learning science through a second language in many school contexts, there is a need for research to focus on the impact language has on students’ understanding of science concepts. Like other countries, Brunei has adopted a bilingual system of education that incorporates two languages in imparting its curriculum. For the first three years of school, Brunei children are taught in Malay and then for the remainder of their education, instruction is in English. This research is concerned with the influence that this bilingual education system has on children’s learning of science. The purpose was to document the patterns of Brunei students’ developing understandings of the concepts of living and non-living things and examine the impact in the change in language as the medium of instruction. A cross-sectional case study design was used in one primary school. Data collection included an interview ( n = 75), which consisted of forced-response and semi-structured interview questions, a categorisation task and classroom observation. Data were analysed quantitatively and qualitatively. The results indicate that the transition from Malay to English as the language of instruction from Primary 4 onwards restricted the students’ ability to express their understandings about living things, to discuss related scientific concepts and to interpret and analyse scientific questions. From a social constructivist perspective these language factors will potentially impact on the students’ cognitive development by limiting the expected growth of the students’ understandings of the concepts of living and non-living things.

  9. A postmarketing surveillance study of dexrabeprazole in the treatment of acid peptic disorders.

    Science.gov (United States)

    Jain, S C

    2009-02-01

    Dexrabeprazole [R(+) rabeprazole] is a novel proton-pump inhibitor which has recently become available in India for the treatment of acid peptic diseases. Experimental and clinical studies have shown superiority of dexrabeprazole (at half the recommended rabeprazole dose) over rabeprazole in terms of favourable pharmacokinetics, better efficacy and faster and greater healing activity. Results of present study in a large population of 4931 patients of acid peptic disorders, reconfirmed safety and efficacy of dexrabeprazole 10 mg once daily in the treatment of gastro-oesophageal reflux disease and also showed its effectiveness in the treatment of patients with peptic ulcers (gastric/duodenal).

  10. The Study of Seedlings

    NARCIS (Netherlands)

    Jacobs, M.

    1966-01-01

    ”The seedling represents the most critical stage in the life of a tree. Conditions of seeding and germination may be entirely favourable, and natural seedlings may appear in countless quantities at the beginning of the rainy season, only to disappear largely or entirely within a comparatively short

  11. Effect of pre-hospital advanced airway management for out-of-hospital cardiac arrest caused by respiratory disease: a propensity score-matched study.

    Science.gov (United States)

    Ohashi-Fukuda, N; Fukuda, T; Yahagi, N

    2017-05-01

    Optimal pre-hospital care for out-of-hospital cardiac arrest (OHCA) caused by respiratory disease may differ from that for OHCA associated with other aetiologies, especially with respect to respiratory management. We aimed to investigate whether pre-hospital advanced airway management (AAM) was associated with favourable outcomes after OHCA caused by intrinsic respiratory disease. This nationwide, population-based, propensity score-matched study of adult patients in Japan with OHCA due to respiratory disease from 1 January 2005 to 31 December 2012 compared patients with and without pre-hospital AAM. The primary outcome was neurologically favourable survival at one month after the OHCA. Of 49,534 eligible patients, 20,458 received pre-hospital AAM and 29,076 did not. In a propensity score-matched cohort (18,483 versus 18,483 patients), the odds of neurologically favourable survival were significantly lower for patients receiving pre-hospital AAM (0.6% versus 1.5%; odds ratio [OR] 0.42 [95% confidence interval {CI} 0.34 to 0.52]). The results from multivariable logistic regression analysis also showed that pre-hospital AAM was significantly associated with a decreased chance of neurologically favourable survival (adjusted OR 0.43 [95% CI 0.35 to 0.52]). Similar findings were observed for one-month survival and pre-hospital return of spontaneous circulation. In subgroup analyses, pre-hospital AAM was associated with poor neurological outcomes, regardless of the type of airway device used (laryngeal mask airway, adjusted OR 0.35 [95% CI 0.19 to 0.57]; oesophageal obturator airway, adjusted OR 0.44 [95% CI 0.35 to 0.55]; and endotracheal tube, adjusted OR 0.47 [95% CI 0.30 to 0.69]). In conclusion, pre-hospital AAM was associated with poor neurological outcome among patients with OHCA caused by intrinsic respiratory disease.

  12. Fruit and vegetables and cancer risk: a review of southern European studies.

    Science.gov (United States)

    Turati, Federica; Rossi, Marta; Pelucchi, Claudio; Levi, Fabio; La Vecchia, Carlo

    2015-04-01

    High intakes of fruit and vegetables may reduce the risk of cancer at several sites. Evidence has been derived mainly from case-control studies. We reviewed the relationship between consumption of vegetables and fruit and the risk of several common cancers in a network of Italian and Swiss case-control studies including over 10,000 cases of fourteen different cancers and about 17,000 controls. Data were suggestive of a protective role of vegetable intake on the risk of several common epithelial cancers. OR for the highest compared with the lowest levels of consumption ranged from 0.2 (larynx, oral cavity and pharynx) to 0.9 (prostate). Inverse associations were found for both raw and cooked vegetables, although for upper digestive tract cancers the former were somewhat stronger. Similar inverse associations were found for cruciferous vegetables. Frequent consumption of allium vegetables was also associated with reduced risk of several cancers. Fruit was a favourable correlate of the risk of several cancers, particularly of the upper digestive tract, with associations generally weaker than those reported for vegetables. A reduced risk of cancers of the digestive tract and larynx was found for high consumption of citrus fruit. Suggestive protections against several forms of cancer, mainly digestive tract cancers, were found for high consumption of apples and tomatoes. High intakes of fibres, flavonoids and proanthocyanidins were inversely related to various forms of cancer. In conclusion, data from our series of case-control studies suggested a favourable role of high intakes of fruit and vegetables in the risk of many common cancers, particularly of the digestive tract. This adds evidence to the indication that aspects of the Mediterranean diet may have a favourable impact not only on CVD, but also on several common (epithelial) cancers, particularly of the digestive tract.

  13. The Future and Prospect of the Association of Southeast Asian Nations

    Science.gov (United States)

    1994-06-01

    of Brunei in the ASEAN became the corner stone of its external legitimacy in 1984. The absolute monarch of Brunei or the Malay Muslim Monarch ( Melayu ...Brunei Darussalam as the Beraja Islam Melayu (Monarchical Islamic Malay) state. The legitimacy of the rule of the Sultan which bases its governance on the

  14. Limnological study with reference to fish culture of Bothali (Mendha) reservoir, district - Gadchiroli (India).

    Science.gov (United States)

    Tijare, Rajendra V

    2012-04-01

    Limnological study with reference to fish culture was carried out at Bothali (Mendha) reservoir, district Gadchiroli, India. Water samples from different sampling locations were collected and processed for physico-chemical analysis. The physico-chemical analysis revealed that the reservoir is favourable for fish culture as the phosphate content in water is moderate in amount. This reservoir can produce a good yield of fishes. Though the reservoir is presently exploited and is under pisciculture, a better treatment of the reservoir such as prevention of entry of organic matter, reduction of phosphate ion concentration to certain extent is necessary to obtain a maximum fish yield.

  15. Reduction of Copper Oxide by Formic Acid an ab-initio study

    CERN Document Server

    Schmeißer, Martin

    2012-01-01

    Four cluster models for a copper(I)oxide (111) surface have been designed, of which three were studied with respect to their applicability in density functional calculations in the general gradient approximation. Formic acid adsorption on these systems was modelled and yielded four different adsorption structures, of which two were found to have a high adsorption energy. The energetically most favourable adsorption structure was further investigated with respect to its decomposition and a few reactions with adsorbed H and OH species using synchronous transit methods to estimate reaction barriers and single point energy calculations for the reaction energy.

  16. A Study of Trend of Animal Experimentation in Medical Education in India

    Directory of Open Access Journals (Sweden)

    Jaswant Rai, Amandeep Singh

    2006-04-01

    Full Text Available A debate on the continuation or discontinuation of animal experiments in pharmacological practicalteaching of medical undergraduates is still in progress.The present study has been done to know thecurrent status of animal experiments in medical education in India using structured questionary. 81.25%pharmacologists and 74% of the medical graduates and clinicians favour the continuation of animalexperiments, preferably with the refinement or reduction of use of animals.Animal based experimentsplay a pivotal role in pharmacological teaching and research in India. However the pattern of practicalpharmacology teaching is not uniform and specific guidelines should be framed to ensure uniformity.

  17. Youths’ Entrepreneurial Behaviour and Intentions. Empirical Study on Students with Entrepreneurship Education

    Directory of Open Access Journals (Sweden)

    Nițu–Antonie Renata

    2013-12-01

    Full Text Available The research aimed to identify the psychological and behavioural characteristics as potential triggers of youths’ entrepreneurial intentions within the context of rational action and planned behaviour theory. The empirical study proposed nine antecedents of entrepreneurial intentions for Romanian students with entrepreneurial higher education background. The results emphasized that behavioural variables (favourable subjective norms and attitude development, perceived behavioural control influence entrepreneurial intentions in a higher degree than the psychological ones (propensity to risk-taking, self-confidence, need for achievement, innovativeness. Moreover, some psychological variables (locus of control and tolerance of ambiguity have been identified as having insignificant influence on entrepreneurial intentions of the respondent students.

  18. Study of the influence of agricultural waste on the porosity of clay brick

    Directory of Open Access Journals (Sweden)

    Chelouah Nasser

    2015-02-01

    Full Text Available This paper deals with the influence of two organic residues on the porosity of clay bricks. The insulation capacity of the brick increases with increasing the porosity. Combustible organic additions are often used to form pores. The formation of the more homogenous porous structure is favourably impacted by using the crushed rough olive stones containing oil. Plasticity, bulk density and mechanical properties were studied. The additions of organic residues have proved successful to form pores while maintaining the mechanical properties in the limits of the Algerian norms.

  19. Study Regarding the Play of the wing player at the World Handball Championship – Serbia 2013

    Directory of Open Access Journals (Sweden)

    Ionică CĂRĂBAŞ

    2013-12-01

    Full Text Available The ascension to the top of the world hierachy in hanball implies a minutiously preparation, considering all the factors of the sporting training, of the players who compose the team. If, not long ago, a team having a 9 m line and a valuable goalkeeper could lean the victory balance in its favour, nowadays, a team can not win a high level competition without having very valuable players on the other posts too. Considering the aspects presented, the study proposes to demonstrate the importance of the players` contribution who evolve on the wing post, in the modern handball game.

  20. Translator Attitudes towards Translator-Computer Interaction – Findings from a Workplace Study

    DEFF Research Database (Denmark)

    Bundgaard, Kristine

    2016-01-01

    ), referred to as MT-assisted TM translation, and in this type of tool, translators switch between editing TM matches and post-editing MT matches. It is generally assumed that translators’ attitudes towards technology impact on this interaction with the technology. Drawing on Eagly/Chaiken’s (1995) definition...... of attitudes as evaluations of entities with favour or disfavour and on qualitative data from a workplace study of TCI, conducted as part of a PhD dissertation (Bundgaard 2017) and partly reported on in Bundgaard et al. (2016), this paper explores translator attitudes towards TCI in the form of MT-assisted TM...

  1. Crossover studies with survival outcomes.

    Science.gov (United States)

    Buyze, Jozefien; Goetghebeur, Els

    2013-12-01

    Crossover designs are well known to have major advantages when comparing the effect of two treatments which do not interact. With a right-censored survival endpoint, however, this design is quickly abandoned in favour of the more costly parallel design. Motivated by human immunodeficiency virus (HIV) prevention studies which lacked power, we evaluate what may be gained in this setting and compare parallel with crossover designs. In a heterogeneous population, we find and explain a substantial increase in power for the crossover study using a non-parametric logrank test. With frailties in a proportional hazards model, crossover designs equally lead to substantially smaller variance for the subject-specific hazard ratio (HR), while the population-averaged HR sees negligible gain. Its efficiency benefit is recovered when the population-averaged HR is reconstructed from estimated subject-specific hazard rates. We derive the time point for treatment crossover that optimizes efficiency and end with the analysis of two recent HIV prevention trials. We find that a Cellulose sulphate trial could have hardly gained efficiency from a crossover design, while a Nonoxynol-9 trial stood to gain substantial power. We conclude that there is a role for effective crossover designs in important classes of survival problems.

  2. Measures to restore metallurgical mine wasteland using ecological restoration technologies: A case study at Longnan Rare Earth Mine

    Science.gov (United States)

    Rao, Yunzhang; Gu, Ruizhi; Guo, Ruikai; Zhang, Xueyan

    2017-01-01

    Whereas mining activities produce the raw materials that are crucial to economic growth, such activities leave extensive scarring on the land, contributing to the waste of valuable land resources and upsetting the ecological environment. The aim of this study is therefore to investigate various ecological technologies to restore metallurgical mine wastelands. These technologies include measures such as soil amelioration, vegetation restoration, different vegetation planting patterns, and engineering technologies. The Longnan Rare Earth Mine in the Jiangxi Province of China is used as the case study. The ecological restoration process provides a favourable reference for the restoration of a metallurgical mine wasteland.

  3. TOWARDS LEARNER-CENTRED MEDICAL CURRICULUM: QUALITATIVE FOCUS GROUP STUDY OF INDIVIDUAL PREFERENCES DEPENDING ON VERBAL ENVIRONMENT.

    Science.gov (United States)

    Bukeyeva, A; Riklefs, V; Riklefs, I; Tashkenbayeva, V; Kassatova, A

    2016-05-01

    There is a strong evidence in medical education literature that the learner-centred curriculum favouring the use of metacognition and self-learning is very proficient. However, ethnocultural and verbal environment may undermine learners' ability to utilise the learning strategies, leading to inefficient learning. This study aimed to investigate the personal preferences of learners in multilingual educational environment prompting the most efficient learning. The study uses qualitative focus group methodology to understand students' opinion on how educational environment influences the efficiency of medical school curriculum.

  4. Agomelatine versus Sertraline: An Observational, Open-labeled and 12 Weeks Follow-up Study on Efficacy and Tolerability

    Science.gov (United States)

    Akpınar, Esma; Cerit, Cem; Talas, Anıl; Tural, Ümit

    2016-01-01

    Objective In this open-labeled, 12 weeks follow-up study, we aimed to compare the efficacy and tolerability of agomelatine with sertraline Methods The outpatients of adult psychiatry clinic who have a new onset of depression and diagnosed as ‘major depressive episode’ by clinician according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition and prescribed agomelatine (25 mg/day) or sertraline (50 mg/day) were included in the study. Results The decline of mean Montgomery-Asberg Depression Rating Scale (MADRS) scores of agomelatine group was significantly higher than the sertraline group at the end of 2nd week; however, the difference was not significant at the end of 3 months. Mean Clinical Global Impression-Improvement scale (CGI-I) scores of agomelatine group was lower than sertraline group at first week. Mean CGI-Severity scale and CGI-I scores were favour to sertraline group at the end of the study. Remission rates were 46.7% for sertraline group and 33.3% for agomelatine group while response rates were 76.7% for both groups. Any patient from agomelatine group dropped-out due to adverse effects. The amount of side effects was also less with agomelatine. Conclusion Agomelatine has a rapid onset efficacy on depressive symptoms and this can be beneficial for some critical cases. Considering MADRS scores, agomelatine seems to have similar efficacy with sertraline but we also point the need for long term studies since CGI scores were favour to sertraline group at the end of the study. Agomelatine has a favourable tolerability profile both in terms of discontinuation and the amount of side effects compared to sertraline. PMID:27776387

  5. Proceedings from Workshop on System Studies of Integrated Solid Waste Management

    Energy Technology Data Exchange (ETDEWEB)

    Sundqvist, Jan-Olov (ed.) [Swedish Environmental Research Institute, Stockholm (Sweden); Finnveden, Goeran (ed.) [Stockholm Univ. and Swedish Defence Research Agency, Stockholm (Sweden). Environmental Strategies Research Group; Sundberg, Johan (ed.) [Chalmers Univ. of Technology, Goeteborg (Sweden). Div. of Energy Systems Technology

    2002-12-01

    This international workshop was held to discuss results and experience from system studies of waste management system and methodological questions and issues based on case studies. The workshop gathered more than 40 participants. These proceedings document more than 20 presentations as well as six discussion sessions. An overall aim of the workshop was to draw some general conclusions from the presented studies concerning - waste strategies that generally seem to be favourable or not favourable - methodological approaches and assumptions that can govern the results - lack of knowledge. Considering the environmental aspects, the presented studies indicated that the waste hierarchy seems to be valid: - Paper and plastic: Material recycling < Incineration < Landfilling - Biodegradable waste: Incineration {approx} Anaerobic digestion < Composting < Landfilling. A number of key aspects that can influence the results were identified: - Avoided products (heat, electricity, material, fertiliser produced from waste). - Efficiency in power plants, heating plants etc. and also recycling plants. - Emissions and impacts from recycling plants - Landfilling models, e.g. time frames. - Final sinks: there should be a distinction between temporary sinks (landfills) and final sinks - Local conditions and local impacts are often neglected. - Electricity production - Choice of alternatives to compare can have an influence on the conclusions drawn. - Stakeholders influence. - Linear modelling. - Data gaps. Especially data on toxic substances where identified as an important data gap.

  6. Determinants of artificial DIF – a study based on simulated polytomous data

    Directory of Open Access Journals (Sweden)

    Curt Hagquist

    2015-09-01

    Full Text Available A general problem in DIF analyses is that some items favouring one group can induce the appearance of DIF in others favouring the other group. Artificial DIF is used as a concept for describing and explaining that kind of DIF which is an artefact of the procedure for identifying DIF, contrasting it to real DIF which is inherent to an item. The purpose of this paper is to elucidate how real both uniform and non-uniform DIF, referenced to the expected value curve, induce artificial DIF, how this DIF impacts on the person parameter estimates and how different factors affect real and artificial DIF, in particular the alignment of person and item locations. The results show that the same basic principles apply to non-uniform DIF as to uniform DIF, but that the effects on person measurement are less pronounced in non-uniform DIF. Similar to artificial DIF induced by real uniform DIF, the size of artificial DIF is determined by the magnitude of the real non-uniform DIF. In addition, in both uniform and non-uniform DIF, the magnitude of artificial DIF depends on the location of the items relative to the distribution of the persons. In contrast to uniform DIF, the direction of non-uniform real DIF (e.g. favouring one group or the other is affected by the location of the items relative to the distribution of the persons. The results of the simulation study also confirm that regardless of type of DIF, in the person estimates, artificial DIF never balances out real DIF.

  7. The geographical digital divide in broadband access and governmental policies in Japan: three case studies

    Directory of Open Access Journals (Sweden)

    Yoshio Arai

    2013-06-01

    Full Text Available Broadband access is indispensable for advanced Internet services, because voluminous data transfers have recently become popular in developed societies. Although broadband access has spread to a certain degree in developed countries/regions, geographical gaps in broadband access (the so-called “geographical digital divide” remain. Based on three case studies in less-favoured areas of Japan (Hokkaido, Nagano Prefecture and Mie Prefecture, we examined how the geographical digital divide is being bridged, and the contributions that national and local government policies make to this process. Several implications were apparent. First, integrating communication infrastructures with manifold digital services, such as cable television services and broadband access, is an effective way to extend broadband to less-favoured areas. The Japanese government has promoted the construction of digital cable television networks, and they have played a significant role in the completion of universal broadband services. The challenge of digitizing terrestrial television broadcasting has been behind these policies. Another effective means of extending broadband has been the pressure exerted by local governments (under the national policy scheme on private cable television companies to bring their services to even the least populated regions. Finally, in those areas where private digital network services are unprofitable, the establishment of a publicly funded cable business (using a budget-transfer scheme, for example may be an effective option for extending broadband services. In general, the challenge of bridging the geographical digital divide should be tackled with a broad set of regional promotion policies for less-favoured regions.

  8. Interdisciplinary analysis of the chances of implementation of an energy conservation and air pollution abatement policy. Adverse and favourable conditions for rational energy use in private households and their responsible decision-makers from an economic and social psychological perspective; Interdisziplinaere Analyse der Umsetzungschancen einer Energiespar- und Klimaschutzpolitik. Hemmende und foerdernde Bedingungen der rationellen Energienutzung fuer private Haushalte und ihr Akteursumfeld aus oekonomischer und sozialpsychologischer Perspektive

    Energy Technology Data Exchange (ETDEWEB)

    Hennicke, P.; Jochem, E.; Prose, F.

    1997-08-01

    The investigation attempted an analysis of the causes and remedies of the gap between ecological and climate-relevant requirements on the one hand and public and political action on the other hand. It presents a theoretical concept for an ecologically oriented social restructuring process which will support rational energy use and the appropriate research and development measures more strongly than it does now. While the Federal government intends a 25 % reduction of carbon dioxide emissions by 2005, an 80 % reduction is required on a long-term basis (e.g. by 2050). In view of this, the contribution of the German government is interpreted as a necessary but still insufficient contribution to sustainability. [German] Diese Studie erarbeitet einen Beitrag zur Analyse der Ursachen und Loesungsmoeglichkeiten fuer den Widerspruch zwischen umwelt- und klimarelevanten Handlungsnotwendigkeiten einerseits und den gesellschaftlichen Handlungsdefiziten andererseits. Weitergehend erbringt sie einen theoretisch-konzeptionellen Ansatz zum oekologischen Umbau der Industriegesellschaft. Dadurch wird konkret dazu beigetragen, die Politik zur rationellen Energieanwendung einschliesslich der Forschungs- und Entwicklungspolitik besser als bisher zu unterstuetzen. Ausgegangen wird von dem energie- und klimapolitischen Ziel der Bundesregierung, bis zum Jahr 2005 die CO{sub 2}-Emissionen gegenueber dem Referenzjahr 1990 um 25% zu reduzieren. Langfristig, bis etwa zum Jahr 2050, ist nach der Empfehlung der Klima-Enquete-Kommission eine CO{sub 2}-Reduktion um 80% erforderlich. Dieser Beitrag der Bundesrepublik zum internationalen Klimaschutz kann als notwendige, wenn auch noch nicht hinreichende Voraussetzung fuer eine 'zukunftsfaehige Entwicklung' (sustainability) in der Bundesrepublik interpretiert werden. (orig.)

  9. Trapping of oxygen vacancies on twin walls of CaTiO sub 3 : a computer simulation study

    CERN Document Server

    Calleja, M; Salje, E K H

    2003-01-01

    We have studied the atomic structure of [001] 90 deg. rotation twin walls in orthorhombic CaTiO sub 3 (symmetry Pbnm) at low temperature (10 K) and their effects on oxygen vacancies. The wall thickness was found to be 2.3 nm at T || T sub c and it was found that it is energetically favourable for such vacancies to reside in the wall, particularly when bridging titania ions in the (001) plane. The binding energy of an oxygen vacancy in the wall with respect to the bulk is calculated to be <= 1.2 eV.

  10. Trapping of oxygen vacancies on twin walls of CaTiO{sub 3}: a computer simulation study

    Energy Technology Data Exchange (ETDEWEB)

    Calleja, Mark; Dove, Martin T; Salje, Ekhard K H [Mineral Physics Group, Department of Earth Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EQ (United Kingdom)

    2003-04-16

    We have studied the atomic structure of [001] 90 deg. rotation twin walls in orthorhombic CaTiO{sub 3} (symmetry Pbnm) at low temperature (10 K) and their effects on oxygen vacancies. The wall thickness was found to be 2.3 nm at T || T{sub c} and it was found that it is energetically favourable for such vacancies to reside in the wall, particularly when bridging titania ions in the (001) plane. The binding energy of an oxygen vacancy in the wall with respect to the bulk is calculated to be {<=} 1.2 eV.

  11. Organisational justice and change in justice as predictors of employee health: the Whitehall II study.

    Science.gov (United States)

    Kivimäki, Mika; Ferrie, Jane E; Head, Jenny; Shipley, Martin J; Vahtera, Jussi; Marmot, Michael G

    2004-11-01

    Organisational justice has been proposed as a new way to examine the impact of psychosocial work environment on employee health. This article studied the justice of interpersonal treatment by supervisors (the relational component of organisational justice) as a predictor of health. Prospective cohort study. Phase 1 (1985-88) measured relational justice, job demands, job control, social support at work, effort-reward imbalance, and self rated health. Relational justice was assessed again at phase 2 (1989-90) and self rated health at phase 2 and phase 3 (1991-93). 20 civil service departments originally located in London. 10 308 civil servants (6895 men, 3413 women) aged 35-55. Self rated health. Men exposed to low justice at phase 1 or adverse change in justice between phase 1 and phase 2 were at higher risk of poor health at phase 2 and phase 3. A favourable change in justice was associated with reduced risk. Adjustment for other stress indicators had little effect on results. In women, low justice at phase 1 predicted poor health at phase 2 and phase 3 before but not after adjustment for other stress indicators. Adverse change in justice was associated with worse health prospects irrespective of adjustments. The extent to which people are treated with justice in workplaces seems to predict their health independently of established stressors at work. Evidence on reduced health risk after favourable change in organisational justice implies a promising area for health interventions at workplace.

  12. Positive deviance study to inform a Chagas disease control program in southern Ecuador

    Directory of Open Access Journals (Sweden)

    Claudia Nieto-Sanchez

    2015-05-01

    Full Text Available Chagas disease is caused by Trypanosoma cruzi, which is mainly transmitted by the faeces of triatomine insects that find favourable environments in poorly constructed houses. Previous studies have documented persistent triatomine infestation in houses in the province of Loja in southern Ecuador despite repeated insecticide and educational interventions. We aim to develop a sustainable strategy for the interruption of Chagas disease transmission by promoting living environments that are designed to prevent colonisation of rural houses by triatomines. This study used positive deviance to inform the design of an anti-triatomine prototype house by identifying knowledge, attitudes and practices used by families that have remained triatomine-free (2010-2012. Positive deviants reported practices that included maintenance of structural elements of the house, fumigation of dwellings and animal shelters, sweeping with "insect repellent" plants and relocation of domestic animals away from the house, among others. Participants favoured construction materials that do not drastically differ from those currently used (adobe walls and tile roofs. They also expressed their belief in a clear connection between a clean house and health. The family's economic dynamics affect space use and must be considered in the prototype's design. Overall, the results indicate a positive climate for the introduction of housing improvements as a protective measure against Chagas disease in this region.

  13. Positive deviance study to inform a Chagas disease control program in southern Ecuador.

    Science.gov (United States)

    Nieto-Sanchez, Claudia; Baus, Esteban G; Guerrero, Darwin; Grijalva, Mario J

    2015-05-01

    Chagas disease is caused by Trypanosoma cruzi, which is mainly transmitted by the faeces of triatomine insects that find favourable environments in poorly constructed houses. Previous studies have documented persistent triatomine infestation in houses in the province of Loja in southern Ecuador despite repeated insecticide and educational interventions. We aim to develop a sustainable strategy for the interruption of Chagas disease transmission by promoting living environments that are designed to prevent colonisation of rural houses by triatomines. This study used positive deviance to inform the design of an anti-triatomine prototype house by identifying knowledge, attitudes and practices used by families that have remained triatomine-free (2010-2012). Positive deviants reported practices that included maintenance of structural elements of the house, fumigation of dwellings and animal shelters, sweeping with "insect repellent" plants and relocation of domestic animals away from the house, among others. Participants favoured construction materials that do not drastically differ from those currently used (adobe walls and tile roofs). They also expressed their belief in a clear connection between a clean house and health. The family's economic dynamics affect space use and must be considered in the prototype's design. Overall, the results indicate a positive climate for the introduction of housing improvements as a protective measure against Chagas disease in this region.

  14. Therapeutic applications of indium-111-octreotide for carcinoid syndrome. A case study

    Energy Technology Data Exchange (ETDEWEB)

    Camden, B.M.; Chu, J.M.G. [Liverpool Health Service, Liverpool, NSW (Australia). Department of Nuclear Medicine and Clinical Ultrasound

    1998-06-01

    Full text: A 83 year old female presented to our department for an Indium-111 Octreotide study to evaluate her carcinoid syndrome with the view of delivering therapeutic doses of Indium-111 Octreotide. Indium-111 Octreotide uptake has been shown in tumours with high-affinity somatostatin receptor sites. In many instances a positive scintigram predicts a favourable response to treatment with Octreotide. The diagnostic scan appearance demonstrated abnormal increased focal uptake in multiple sites of both lobes of the liver and one in the right iliac fossa, her primary site. Before the therapeutic doses, both haematological and biochemical indices of her carcinoid were performed to evaluate therapeutic response. The patient was then admitted into our isolation room and underwent 3 therapeutic doses of Indium-111 Octreotide of between 180 and 350 mCi intravenously at 4 to 6 weekly intervals. A post-therapeutic total body scan with abdominal SPECT was performed after each dose to assess therapeutic uptake and response. Before the second therapeutic dose, an FDG coincidence PET study was performed. This scan corresponded with similar sites of uptake to the Octreotide scan The patient has now had 2 of her 3 therapeutic doses with the third due in late January 1998. At this point of time her biochemical indices and clinical facial flushing and diarrhoea have shown favourable response to therapy

  15. Arsine and its fluoro, chloro derivatives: a computational thermochemical study

    Science.gov (United States)

    Bagchi, Sabyasachi; Mondal, Bhaskar; Ghosh, Deepanwita; Das, Abhijit K.

    2010-01-01

    The structures, vibrational frequencies, enthalpies of formation and dissociation energies of arsine, arsenic hydrides and their fluoro, chloro derivatives have been studied using density functional B3LYP/cc-pVDZ, ab-initio MP2/cc-pVDZ and composite CBS-QB3 and CBS-Q methods. Computed standard enthalpies of formation at 298 K by atomisation scheme are compared with reported values. Bond dissociation energies at 0 K are calculated for all possible thermal dissociation of the molecular species in gas phase, from which the energetically most favourable dissociation pathways are predicted. The calculated enthalpies of formation and bond dissociation energies are correlated with the nature of bonding in arsine and its fluoro, chloro derivatives. Energy barriers at 0 K are calculated and transition states are located for the molecular fragment elimination of the thermal dissociation reactions.

  16. STUDY ON EVOLUTION OF RURAL TOURISM IN ROMANIA

    Directory of Open Access Journals (Sweden)

    CEAUSESCU IONUT

    2016-12-01

    Full Text Available In Romania,the long period of transition to a market economy has determined the restructuring in all spheres of activity, triggering multiple economic-social, political and cultural implications. Thus, the city life of today involves a lot of stress, at the same time there is a high degree of urbanization and environmental pollution. These changes have affected tourism in the sense of a change in holiday destinations in favor of its assets, in the midst of nature, with favourable and deep implications in rural tourism activity. These are just a few short arguments representing the circumstances that make us realize this study on the evolutionary trends of rural tourism activity from Romania, which are described and analyzed on the basis of statistical data obtained from the Statistical pocket-book "Romanian Tourism", editions 2009-2015, published by the National Institute of Statistics.

  17. Writing to learn writing skills - a case study

    Science.gov (United States)

    Fernandes, António S. C.

    2012-05-01

    The paper describes a case study in which the main objective is to understand how engineering students can improve their writing skills, regarding spelling and syntax, when taught specifically on these issues. The methodology Writing To Learn is applied in two courses and, making use of the written texts, the students' writing skills are assessed and evaluated. In one course, writing skills are taught and assessed and in the other they are only assessed. The comparison allows conclusions on the success of teaching writing skills, the influence of text styles and the differences between basic and advanced writing skills. It was found that writing skills were successfully taught, particularly with regard to basic writing skills. Advanced writing errors are twice as common as basic writing errors. Schematic writing styles favour a reduced number of writing errors.

  18. Studies of the Prefabricated Housing Construction Market in Poland

    Science.gov (United States)

    Radziszewska-Zielina, Elżbieta; Gleń, Monika

    2014-11-01

    The directions of development of the construction market are not only related to the need to own one's own home but also to increasing functional and economic requirements and conditions of sustainable development. The perception and understanding of prefabrication in housing construction are undoubtedly starting to change. Sustainable construction criteria may constitute a significant turning point and support for the development of new prefabricated housing construction technologies. Entrepreneurs are slowly perceiving an opportunity for the development of prefabrication in the construction market. The implementation and popularisation of ready-made homes will undoubtedly constitute a favourable change in the Polish construction market; however, this will require a modification of habits. This article presents an historical analysis of the development of the prefabricated housing construction market as well as an attempt to answer questions concerning the future of prefabrication in housing construction in Poland based on the conducted studies.

  19. Studies of the Prefabricated Housing Construction Market in Poland

    Directory of Open Access Journals (Sweden)

    Radziszewska-Zielina Elżbieta

    2014-11-01

    Full Text Available The directions of development of the construction market are not only related to the need to own one’s own home but also to increasing functional and economic requirements and conditions of sustainable development. The perception and understanding of prefabrication in housing construction are undoubtedly starting to change. Sustainable construction criteria may constitute a significant turning point and support for the development of new prefabricated housing construction technologies. Entrepreneurs are slowly perceiving an opportunity for the development of prefabrication in the construction market. The implementation and popularisation of ready-made homes will undoubtedly constitute a favourable change in the Polish construction market; however, this will require a modification of habits. This article presents an historical analysis of the development of the prefabricated housing construction market as well as an attempt to answer questions concerning the future of prefabrication in housing construction in Poland based on the conducted studies.

  20. Alpha Anisotropy Studies of Near-Spherical and Deformed Nuclei

    CERN Multimedia

    Van Duppen, P

    2002-01-01

    % IS329 \\\\ \\\\ Although it was the first decay mode to be discovered, the process of $\\alpha$-particle emission is still poorly understood. A few years ago the first systematic study of anisotropic $\\alpha$-decay triggered renewed theoretical interest. Nevertheless, today the theories are still not adequate enough and more experimental data are urgently needed. We therefore measure the $\\alpha$-anisotropies of the favoured transitions of a number of near-spherical Rn and At isotopes, and of deformed nuclei near A=220. As the different models yield contradictory predictions for the transitions that are investigated, the measurements will allow to discern on their validity. They will at the same time provide the necessary basis for further theoretical developments.