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Treatment Option Overview (Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer)

Science.gov (United States)

... diagnosed, tests are done to find out if cancer cells have spread within the ovaries or to other parts of the body. The ... single ovary or fallopian tube. In stage IB, cancer is found inside both ovaries or fallopian tubes. In stage IC, cancer is ...

Selective salpingography and recanalisation of blocked fallopian tubes.

LENUS (Irish Health Repository)

Allen, C

2010-09-01

Fallopian tubal disease is a common cause of subfertility. Reproductive surgery or assisted reproduction techniques such as in vitro fertilization (IVF) have been the main treatment options for patients with tubal disease in Ireland, although access to these treatments remains limited. We describe a case of pregnancy following selective salpingography and fallopian tube recanalisation.

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Lifescience Database Archive (English)

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In vivo laser-based imaging of the human fallopian tube for future cancer detection

Science.gov (United States)

Seibel, Eric J.; Melville, C. David; Johnston, Richard S.; Gong, Yuanzheng; Agnew, Kathy; Chiang, Seine; Swisher, Elizabeth M.

2015-03-01

Inherited mutations in BRCA1 and BRCA2 lead to 20-50% lifetime risk of ovarian, tubal, or peritoneal carcinoma. Clinical recommendations for women with these genetic mutations include the prophylactic removal of ovaries and fallopian tubes by age 40 after child-bearing. Recent findings suggest that many presumed ovarian or peritoneal carcinomas arise in fallopian tube epithelium. Although survival rate is screening techniques have mistakenly focused on the ovary as origin of ovarian carcinoma. Unlike ovaries, the fallopian tubes are amenable to direct visual imaging without invasive surgery, using access through the cervix. To develop future screening protocols, we investigated using our 1.2- mm diameter, forward-viewing, scanning fiber endoscope (SFE) to image luminal surfaces of the fallopian tube before laparoscopic surgical removal. Three anesthetized human subjects participated in our protocol development which eventually led to 70-80% of the length of fallopian tubes being imaged in scanning reflectance, using red (632nm), green (532nm), and blue (442nm) laser light. A hysteroscope with saline uterine distention was used to locate the tubal ostia. To facilitate passage of the SFE through the interstitial portion of the fallopian tube, an introducer catheter was inserted 1- cm through each ostia. During insertion, saline was flushed to reduce friction and provide clearer viewing. This is likely the first high-resolution intraluminal visualization of fallopian tubes.

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File list: InP.Utr.20.AllAg.Fallopian_tube_secretory_epithelial_cell [Chip-atlas[Archive

Lifescience Database Archive (English)

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Treatment Options by Stage (Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer)

Science.gov (United States)

... diagnosed, tests are done to find out if cancer cells have spread within the ovaries or to other parts of the body. The ... single ovary or fallopian tube. In stage IB, cancer is found inside both ovaries or fallopian tubes. In stage IC, cancer is ...

Effects of contrast agents on the fallopian tube in a rabbit model

International Nuclear Information System (INIS)

Moore, D.E.

1989-01-01

Selection of the optimal contrast agent for hysterosalpingography was the focus of this study. The authors have evaluated the effect of different iodinated contrast agents on the fallopian tube of a rabbit. Ethiodol (oil-soluble contrast agent), methylglucamine iothalomate (water-soluble ionic agent) 30% and 60%, and Ioxilan (water-soluble monionic contrast agent) were compared. The agents were introduced by fallopian tube catheterization. Findings suggested that nonionic water-soluble contrast agents were the least detrimental to the fallopian tube and surrounding tissue. Iothalomate 60% resulted in mild inflammatory changes. Oil-soluble contrast agents caused granulomatous reaction and fibrinous adhesions

Primary Fallopian Tube Carcinoma: A Case Report and Literature Review.

Science.gov (United States)

Rexhepi, Meral; Trajkovska, Elizabeta; Ismaili, Hysni; Besimi, Florin; Rufati, Nagip

2017-06-15

Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer. We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA. The patient has lower abdominal pain, watery vaginal discharge and repeated episodes of bleeding from the vagina. The clinical and radiological findings suggested a right adnexal tumour with elevated CA-125 levels. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy and peritoneal washing were performed. Pathologic confirmation of primary serous cystadenocarcinoma of the right fallopian tube was made. Peritoneal washings were negative for malignancy. FIGO stage was considered as IA, and the patient received no courses of chemotherapy and postoperative radiation because she refused it. Ten months after initial surgery, the patient is alive and in good condition. Cytoreduction surgery followed by adequate cycles of chemotherapy is an important strategy to improve patients' prognosis.

Primary Adenocarcinoma of the fallopian tube: Case Report

Directory of Open Access Journals (Sweden)

Mert Kazandi

2010-10-01

Full Text Available Carcinoma of the follapian tube accounts for only 0.3 to 1.1% of all gynecologic malignancies. Primer carsinoma of follapian tube is a rare and aggressive cancer. It is not diagnosed until at an advanced stage. Because its epidemiologic, biologic and prognostic characteristics arent well known, no standart treatment has been developed. Most of them are adenocarcinomas. Stage is significant prognostic factor. Typical clinical symptoms are vaginal bleeding, watery discharge and pelvic pain. Tubal carsinomas are treated with surgical and chemotherapeutic approach as epithelial ovarian cancer. We reported a 76 year-old woman with primer fallopian tube carcinomas. The case presented with postmenopausal vaginal bleeding. Endometrial curettage showed no abnormal findings. However, we performed laparotomy because of ongoing vaginal bleeding after currettage and left adnexal mass. In the laparotomy, left tube was observed hydropic. The histopathologic result of the left tube revealed primer fallopian tube adenocarcinoma. We performed hysterectomy and bilateral salpingo-oophorectomy. She has been given chemotherapy (endoxan-carboplatin treatment for 4 mounths.

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Lifescience Database Archive (English)

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File list: NoD.Utr.10.AllAg.Fallopian_tube_secretory_epithelial_cell [Chip-atlas[Archive

Lifescience Database Archive (English)

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A clinical study of fallopian tube recanalization by comptesswely injecting contrast medunm into the uterus

International Nuclear Information System (INIS)

Xi Jiayuan; Jiang Yong; Zhu Ying; Gong Hiafeng; Lv Liang; Zhao Xinxiang; Fang Min; Wei Dingying; Hua Jian

2006-01-01

Objective: To search for a new, simple, rapid, safe and effective method with combination of hystero. Salingography and fallopian tube recanalization. Methods: After the double-lumen balloon catheter was inserted into the uterine cavity and then followed by saline or air injection into to the saccule. The internal os of cervix was thus blocked by the filled saccule. Iohexol was injected into uterine cavity and fallopian tubes to undertake hystero-salingography and selective radiography under the television observation. In case of obstruction the fallopian tube recanalization could be obtained by manual increasing the contrast injection pressure into the uterine cavity. Results: 2698 cases including 811 primary infertile women and 1887 cases of secondary infertilities were examed by this method. The number of obstructed fallopian tube was 3082 including 1561 right fallopian tubes and 1521 left ones. The rate of tube obstruction was 77.77% and that of tube recanalization was 88.96% including 2397 branches recanalized completely and 322 partially recanalizd. The venous reflux was found in 27 cases and light complications included slight vagina bleeding, mild transient spastic pain without mortality. Conclusion: This method of combining hystero-salinography and fallopian tube recanalization, is safe, effective, economic and practical for infertile women with quick procedure process; and worthy to be recommended. (authors)

High grade serous ovarian carcinomas originate in the fallopian tube.

Science.gov (United States)

Labidi-Galy, S Intidhar; Papp, Eniko; Hallberg, Dorothy; Niknafs, Noushin; Adleff, Vilmos; Noe, Michael; Bhattacharya, Rohit; Novak, Marian; Jones, Siân; Phallen, Jillian; Hruban, Carolyn A; Hirsch, Michelle S; Lin, Douglas I; Schwartz, Lauren; Maire, Cecile L; Tille, Jean-Christophe; Bowden, Michaela; Ayhan, Ayse; Wood, Laura D; Scharpf, Robert B; Kurman, Robert; Wang, Tian-Li; Shih, Ie-Ming; Karchin, Rachel; Drapkin, Ronny; Velculescu, Victor E

2017-10-23

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1, BRCA2 or PTEN. Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease.

Isolated torsion of fallopian tube in a post-menopausal patient: a case report.

Science.gov (United States)

Ozgun, Mahmut Tuncay; Batukan, Cem; Turkyilmaz, Cagdas; Serin, Ibrahim Serdar

2007-07-20

Isolated fallopian tube torsion after menopause is a rare condition. Here we report the second case of isolated fallopian tube torsion in a post-menopausal woman. A 55-year-old post-menopausal woman presented with right lower abdominal pain. Sonography depicted a simple cystic mass adjacent to the right uterine border. Laparatomy revealed torsion of the right fallopian tube together with a paraovarian cyst. Total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed. Histopathological examination revealed a simple paraovarian cyst with severe congestion, necrosis and hemorrhage. Tubal torsion should be considered in the differential diagnosis of acute lower abdominal pain, even in post-menopausal women.

Glycogen distribution in porcine fallopian tube epithelium during the estrus cycle.

Science.gov (United States)

Gregoraszczuk, E Ł; Cała, M; Witkowska, E

2000-01-01

Histochemical features of two different parts of the porcine Fallopian tube have been studied, with special reference to cyclic changes in the distribution of glycogen particles. Porcine Fallopian tubes were obtained from a local slaughterhouse. Slides were studied under light microscopy utilising histological and histochemical techniques. The most striking feature during the periovulatory stage of the estrus cycle was the occurrence of glycogen granules in the apical cytoplasm of epithelial cells in both the ampulla and isthmus of the Fallopian tubes. In the isthmus, cells containing numerous granules of polysaccharides aggregated into areas of different sizes were noted after ovulation. During the midluteal phase their number was minimal or were even absent. In the ampula typical extrusion of secretory granules and nuclei protruding into the tubal lumen was visible after ovulation. In the luteal phase a lot of nuclei protruded into the tubal lumen and some free in the lumen were noted. It is possible that glycogen in the preovulatory stage functions as a source of energy for ciliary movement and as a nourishment for the ovum. In the isthmus large number of aggregated glycogen particles was observed also after ovulation. In this stage of the cycle, numerous granules of polysaccharide aggregated in isthmus epithelium could be the major energy source for embriogenesis when the embryo travels down the Fallopian tubes, during the early cleavage stage.

Serous ovarian, fallopian tube and primary peritoneal cancers

DEFF Research Database (Denmark)

Sørensen, Rie D; Schnack, Tine H; Karlsen, Mona A

2015-01-01

OBJECTIVE: The aim of this systematic review is to analyze data on risk factors, epidemiology, clinicopathology and molecular biology from studies comparing primary peritoneal cancer, fallopian tube cancer and ovarian cancer of serous histology, in order to achieve a greater understanding...... of whether or not these disorders should be considered as separate entities. METHODS: A systematic literature search was conducted in PubMed and MEDLINE. Case-control studies comparing primary serous peritoneal or fallopian tube carcinomas with primary serous ovarian carcinomas or a control group were...... included. RESULTS: Twenty-eight studies were found eligible. Primary peritoneal cancer patients were older, had higher parity, were more often obese and had poorer survival compared to ovarian cancer patients. Differences in protein expression patterns of Her2/neu, estrogen and progestin receptors...

Isolated torsion of fallopian tube during pregnancy; report of two cases.

Science.gov (United States)

Yalcin, O T; Hassa, H; Zeytinoglu, S; Isiksoy, S

1997-08-01

Isolated torsion of fallopian tube is very uncommon during pregnancy. Predisposing factors for torsion are hydrosalpinx, prior tubal operation, pelvic congestion, ovarian and paraovarian masses and trauma. Although the most important clinical symptom is abdominal pain in lower quadrants, the diagnosis is usually established during the operation performed for acute abdomen and salpingectomy is almost always necessary. Two cases of torsion of fallopian tube during pregnancy, one with hydrosalpinx, the other with paratubal cyst are presented and symptoms and predisposing factors are discussed.

Primary carcinoma of the Fallopian tubes

International Nuclear Information System (INIS)

Escalona Veloz, Rafael; Lopez Rodriguez, Caridad; Nunnez Quintana, Adrian; Rizo Reve, Rafael

2010-01-01

The clinical case of a 53 year old patient with history of vaginal bleeding for possible uterine fibroma is described. A total hysterectomy with double ooferectomia was performed. The complementary tests results, including the biopsy, confirmed the presence of a primary carcinoma of the right Fallopian tube. A radiotherapy and follow up were indicated in 'Conrado Benitez' Oncology Hospital from Santiago de Cuba

Laparoscopic management of fallopian tube prolapse masquerading as adenocarcinoma of the vagina in a hysterectomized woman

Directory of Open Access Journals (Sweden)

Kucuk Mustafa

2002-01-01

Full Text Available Abstract Background Fallopian tube prolapse as a complication of abdominal hysterectomy is a rare occurrence. A case with fallopian tube prolapse was managed by a combined vaginal and laparoscopic approach and description of the operative technique is presented. Case presentation A 39-year-old woman with vaginal prolapse of the fallopian tube after total abdominal hysterectomy presented with an incorrect diagnosis of adenocarcinoma of the vaginal apex. The prolapsed tube and cystic ovary were removed by vaginal and laparoscopic approach. The postoperative course went well. Conclusions Early or late fallopian tube prolapse can occur after total abdominal hysterectomy and vaginal hysterectomy. Symptoms consist of persistent blood loss or leukorrhea, dyspareunia and chronic pelvic pain. Vaginal removal of prolapsed tube with laparoscopic surgery may be a suitable treatment. The abdominal or vaginal approach used in surgical correction of prolapsed tubes must be decided in each case according to the patient's individual characteristics.

OPT-821 With or Without Vaccine Therapy in Treating Patients With Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer in Second or Third Complete Remission

Science.gov (United States)

2017-09-12

Stage IA Fallopian Tube Cancer; Stage IA Ovarian Cancer; Stage IB Fallopian Tube Cancer; Stage IB Ovarian Cancer; Stage IC Fallopian Tube Cancer; Stage IC Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

Science.gov (United States)

2017-05-03

Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

The effectiveness of different interventional methods for partial fallopian tube obstruction: an analysis of 186 cases

International Nuclear Information System (INIS)

Tan Yiqing; Wang Yase; Dai Hongxiu; Li Haitao; Deng Yi; Xiong Liqin

2011-01-01

Objective: To evaluate selective salpingo-catheterization recanalization therapy in treating partial fallopian tube obstruction through comparing its clinical effectiveness with that of non-interventional radiology methods. Methods: During the period from January 2008 to October 2010, a total of 186 infertility women with partial fallopian tube obstruction, which was confirmed with hysterosalpingography, were encountered in authors' hospital. This study protocol was approved by our hospital ethics committee, and informed consent was obtained from all patients. According of different treatment methods, 186 patients were divided into two groups. Patients (n=78) in group A received non-interventional radiology methods, including hydrotubation, enema, laparoscopy, physical therapy and traditional Chinese medication, while patients (n=108) in group B received selective salpingo-catheterization recanalization therapy. All 186 patients were followed up for more than six months. Close observation on the pregnancy incidence after different treatments and fallopian tube patency was carried out. The clinical findings were documented. The results were statistically analyzed by using paired 'x2' test. Results: Half a year after different procedures, in group A the pregnancy rate was 12.82% (n=10), and different degrees of fallopian tube obstruction were found in 31.58% patients. Whereas in group B, during the same period of observation, the pregnancy rate was 58.33% (n=63), and partial occlusion in cornual region was seen in one patient (0.47%). Significant difference in both pregnancy rate and fallopian tube occlusion rate existed between two groups (P<0.05). Conclusion: Because of its minimal invasiveness, high effectiveness and safety, the selective salpingography together with fallopian tube recanalization procedures are well accepted by the patients. The selective salpingo-catheterization recanalization therapy is superior to non-interventional radiology methods in

Ovarian, Fallopian Tube, and Primary Peritoneal Cancer Prevention

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... black women, but have decreased in both groups. Women who have a family history of ovarian cancer and/or certain inherited gene ... ovarian, fallopian tube, and primary peritoneal cancer: Personal history of breast cancer A woman who has had breast cancer has an increased ...

The association between smoking and ectopic pregnancy: why nicotine is BAD for your fallopian tube.

Directory of Open Access Journals (Sweden)

Andrew W Horne

Full Text Available Epidemiological studies have shown that cigarette smoking is a major risk factor for tubal ectopic pregnancy but the reason for this remains unclear. Here, we set out to determine the effect of smoking on Fallopian tube gene expression. An oviductal epithelial cell line (OE-E6/E7 and explants of human Fallopian tubes from non-pregnant women (n = 6 were exposed to physiologically relevant concentrations of cotinine, the principle metabolite of nicotine, and changes in gene expression analyzed using the Illumina Human HT-12 array. Cotinine sensitive genes identified through this process were then localized and quantified in Fallopian tube biopsies from non-pregnant smokers (n = 10 and non-smokers (n = 11 using immunohistochemistry and TaqMan RT-PCR. The principle cotinine induced change in gene expression detected by the array analysis in both explants and the cell line was significant down regulation (P<0.05 of the pro-apoptotic gene BAD. We therefore assessed the effect of smoking on cell turnover in retrospectively collected human samples. Consistent with the array data, smoking was associated with decreased levels of BAD transcript (P<0.01 and increased levels of BCL2 transcript (P<0.05 in Fallopian tube biopsies. BAD and BCL2 specific immunolabelling was localized to Fallopian tube epithelium. Although no other significant differences in levels of apoptosis or cell cycle associated proteins were observed, smoking was associated with significant changes in the morphology of the Fallopian tube epithelium (P<0.05. These results suggest that smoking may alter tubal epithelial cell turnover and is associated with structural, as well as functional, changes that may contribute to the development of ectopic pregnancy.

Torsion of the normal fallopian tube.

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Provost, M W

1972-01-01

From 1961 to 1970 a number of cases of torsion of the Fallopian tube were seen at the Kaiser Foundation Hospital in San Francisco of which 3 cases are reported. Of the many theories of causation, pelvic congestion seemed the most likely. The only universal symptom is pain, located in the quadrant of the affected tube and sometimes radiating to the thigh or flank. Nausea and vomiting are frequent; temperature and white cell count are only slightly elevated or normal. A mass is often felt, depending on the amount of hemorrhage. Correct diagnosis is almost never made preoperatively. The only treatment is laparotomy and surgical correction.

Serous tubal intraepithelial carcinoma, chronic fallopian tube injury, and serous carcinoma development.

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Malmberg, Karin; Klynning, Charlotta; Flöter-Rådestad, Angelique; Carlson, Joseph W

2016-06-01

Ovarian carcinoma is the deadliest gynecological malignancy. Previous studies have suggested that the fallopian tube may be the primary site for high-grade serous carcinoma. In prophylactic salpingo-oophorectomies from women with hereditary high risk for ovarian cancer, precursors can be assessed prior to onset and studied as a model for serous cancer precursor lesions. Epidemiologic studies indicate that carcinogenesis may be a result of chronic fallopian tube injury. The aims of this study were to (1) to examine the incidence of serous tubal intraepithelial carcinoma (STIC) in relation to other clinical parameters and (2) to evaluate whether chronic fallopian tube injury was related to cancer development. This study enrolled 101 women, comprising the following three groups: hereditary (n = 60), sporadic serous cancer (n = 18; endometrial cancers were excluded), and control (n = 23). The cases were histologically examined and clinical risk factors were collected. The histological changes were compared between different patients and correlated to clinical risk factors. STICs were identified primarily on the fallopian tube fimbria. The incidence of STIC was 3 % in the hereditary patients. In sporadic serous cancer cases, 61 % were associated with STIC and tubal carcinoma (p STIC and invasive cancer were seen more often in the older patients than in the younger patients (p = 0.528). This small study, no correlation with chronic tubal injury or inflammation was identified.

Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

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2017-01-05

Chemotherapeutic Agent Toxicity; Neuropathy; Neurotoxicity Syndrome; Pain; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

Chronic stress effects and their reversibility on the Fallopian tubes and uterus in rats.

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Divyashree, S; Yajurvedi, H N

2018-01-01

The durational effects of chronic stress on the Fallopian tubes and uterus were studied by exposing rats to stressors in the form of restraint (1h) and forced swimming (15min) daily for 4, 8 or 12 weeks. One group of stressed rats from each time period was then maintained without exposure to stressors for a further 4 weeks to assess their ability to recover from stress. All time periods of stress exposure resulted in decreased weight of the body and Fallopian tubes; however, the relative weight of the uterus and serum concentrations of oestradiol and insulin increased significantly. The antioxidant potential was decreased with increased malondialdehyde concentrations in the Fallopian tubes following all durations of exposure and after 4 and 8 weeks of stress exposure in the uterus. Interestingly, rats stressed for 12 weeks showed an increase in serum testosterone concentration and antioxidant enzyme activities with a decrease in malondialdehyde concentration in the uterus. The antioxidant enzyme activities and malondialdehyde concentration in the Fallopian tubes of all recovery group rats were similar to stressed rats. However, in the uterus these parameters were similar to controls in recovery group rats after 4 weeks or 8 weeks of exposure, but after 12 weeks of stress exposure these parameters did not return to control levels following the recovery period. These results reveal, for the first time, that chronic stress elicits an irreversible decrease in antioxidant defence in the Fallopian tubes irrespective of exposure duration, whereas the uterus develops reversible oxidative stress under short-term exposure but increased antioxidant potential with endometrial proliferation following long-term exposure.

Serous papillary cystadenofibroma of the fallopian tube: A case report and short review of literature

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Yasmeen Khatib

2015-01-01

Full Text Available Serous papillary cystadenofibromas (SPCAFs of the fallopian tube are very rare benign tumors of the female genital tract. They are usually asymptomatic and are found incidentally. Until now, only 18 cases of this tumor have been reported in the world literature. We report a case of SPCAF of the left fallopian tube in a 30-year-old female who presented with a large abdominal mass and pain. On computed tomography, a diagnosis of ovarian neoplasm was given. However, during surgery the tumor was found to arise from the fallopian tube and was treated with tubal cystectomy with sparing of the ovary. We present this unique case on account of its rarity, unusual presentation, and huge size along with a short review of literature.

Primary Fallopian Tube Carcinoma

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Prasad K Shetty

2011-01-01

Full Text Available Primary Fallopian Tube Carcinoma (PFTC is rare and accounts for about 0.3% of all gynecologic cancers. Less than 1500 cases have been reported in the literature. It arises in postmenopausal women and typically presents with abdominal pelvic pain, vaginal bleeding and watery discharge. However, a correct diagnosis is rarely achieved preoperative, and in many cases, the diagnosis is made after incidental surgery for unrelated conditions commonly being ovarian carcinoma . Compared with ovarian carcinoma, PFTC more often presents at early stages, but it has a worse prognosis. PFTC is usually managed in the same manner as ovarian cancer. We report a case of Left PFTC that presented as Left ovarian mass, and we briefly review the literature.

A case report of fallopian tube into inguinal canal in patient with unicorn uretus

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Maryam Asgharnia; Ziba Zahiri; Fariba Mirblouk; Fatemeh Hosseinzadeh; seyedeh Fatemeh Dalil Heirati

2014-01-01

Introduction: Presence of the ovary, fallopian tube and uterus within an inguinal canal is a rare condition in women of reproductive age. Case report: In this report we present a 31-year-old female with 5 years primary infertility who was admitted for infertility evaluation. We described a patient with unicornuate uterus without rudimentary horn and the left fallopian tube within the left inguinal canal diagnosed through laparoscopy. Conclusion: The surgeon who works on infertility may encoun...

Abridged republication of FIGO's staging classification for cancer of the ovary, fallopian tube, and peritoneum.

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Prat, Jaime

2015-10-01

Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all 3 cancers in a single system. The primary site (i.e. ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorded. Intraoperative rupture ("surgical spill") is IC1; capsule ruptured before surgery or tumor on ovarian or fallopian tube surface is IC2; and positive peritoneal cytology with or without rupture is IC3. The new staging includes a revision of stage III patients; assignment to stage IIIA1 is based on spread to the retroperitoneal lymph nodes without intraperitoneal dissemination. Extension of tumor from omentum to spleen or liver (stage IIIC) should be differentiated from isolated parenchymal metastases (stage IVB). © 2015 American Cancer Society.

Fallopian tube cancer: incidence and role of lymphatic spread.

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di Re, E; Grosso, G; Raspagliesi, F; Baiocchi, G

1996-08-01

Lymphatic spread pattern in 17 cases of adenocarcinoma of fallopian tube is reported. Median age of the patients was 48 years. All patients underwent surgical staging including total abdominal hysterectomy, bilateral salpingo-oopherectomy omentectomy, and appendectomy. Systematic pelvic and paraaortic lymphadenectomy was feasible in 15 cases. Majority of the patients (11 of 17 cases, 64%) had advanced disease and showed serous adenocarcinoma (83%). Lymph nodes were involved in 10 of 17 cases (59%). Node metastases rate increased significantly (P < 0.01) with intraperitoneal stage of disease and with grading. Interestingly, positive nodes were also found in 2 cases (33%) of 6 patients with disease still limited to fallopian tube. Overall, patients with negative nodes had a median survival of 76 months, compared with only 33 months if node metastases were found. In conclusion, combined pelvic and para-aortic lymphadenectomy seems to be necessary for staging and perhaps for prognosis of this disease.

Correlation of clinical data with fallopian tube specimen immune cells and tissue culture capacity.

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Ramraj, Satish Kumar; Smith, Katie M; Janakiram, Naveena B; Toal, Coralee; Raman, Ankita; Benbrook, Doris Mangiaracina

2018-06-01

Human fallopian tube fimbria secretory epithelial cells (hFTSECs) are considered an origin of ovarian cancer and methods for their culture from fallopian tube specimens have been reported. Our objective was to determine whether characteristics of the donors or surgeries were associated with the capacities of fimbria specimens to generate hFTSEC cultures or their immune profiles. There were no surgical complications attributable to fallopian tube removal. Attempts to establish primary hFTSEC cultures were successful in 37 of 55 specimens (67%). Success rates did not differ significantly between specimens grouped by patient or surgery characteristics. Established cultures could be revived after cryopreservation and none became contaminated with microorganisms. Two cultures evaluated for long term growth senesced between passages 10 and 15. M1 macrophages were the predominant cell type, while all other immune cells were present at much lower percentages. IL-10 and TGF-β exhibited opposing trends with M1 and M2 macrophages. Plasma IL-10 levels exhibited significant positive correlation with patient age. In conclusion, fallopian tube fimbria specimens exhibit a pro-inflammatory phenotype and can be used to provide a source of hFTSECs that can be cultured for a limited time regardless of the donor patient age or race, or the type of surgery performed. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ovarian, Fallopian Tube, and Primary Peritoneal Cancer—Patient Version

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Ovarian epithelial cancer is the most common type of ovarian cancer. Cancer can also form at the end of the fallopian tube near the ovary or the peritoneum and spread to the ovary. Start here to find information on ovarian cancer treatment, causes and prevention, screening, research, and statistics.

Interventional recanalization combined with chinese traditional medicine in the treatment of fallopian tube obstruction

International Nuclear Information System (INIS)

Sun Lizhe; Liu Hui; He Zhao; Wei Feng; Ma Xuanpeng

2004-01-01

Objective: To observe the curative effect of interventional recanalization combined with chinese traditional medicine in treatment of fallopian tube obstruction. Methods: There were 200 cases in treatment group and 120 cases in control group. In the treatment group patients were given chinese herbal medicine after the intervention. In sixth month a follow up imaging was performed assessing the patency. The follow up also included the pregnancy rate 1 year later. Results: The patency rate was 83% in treatment group, and 81.5% in control group (P>0.05). Re-conjunction rate was 7.6% in the study group and 22% in control group (P<0.01). The pregnancy rate was 67% in study group and 42% in control group (P<0.01). Conclusion: With interventional recanalization combined with chinese traditional medicine, good curative effect obtained in treatment of fallopian tube obstructive infertility. Combined with Chinese traditional medicine, the post-procedure re-conjunction rate is decreased, especially in the case of short fallopian tube obstruction

The Strategy of Vascularised Transplantation of the Fallopian Tube

African Journals Online (AJOL)

panying veins and surrounding fascia (Fig. 2). At this stage the animal was heparinised by intravenous administration of 20000 units heparin. The vascular arcades were then carefully inspected to ensure that the blood supply to the distal uterine cornu and Fallopian tube (oviduct) would not be interrupted. The intervascular ...

Fallopian tube occlusion by selective transcatheter radiofrequency electrocautery

Energy Technology Data Exchange (ETDEWEB)

Oh, Joo Hyeong; Yoon, Yup; Ko, Young Tae; Nam, Duck Ho; Park, Yong Koo [Kyung Hee University Hospital, Seoul (Korea, Republic of)

1998-04-01

The purpose of this study is to access the usefulness of transcatheter radiofrequency (RF) electrocautery as a method of nonsurgical tubal occlusion. Using the coaxial technique under fluoroscopic guidance, transvaginal fluoroscopic fallopian tube catheterization was performed in thirteen rabbits. In each rabbit, unilateral tubal ablation was performed using RF electrocautery. A 0.018 inch metallic wire protruding from the microcatheter tip was used as the source of the RF energy; the length of the noninsulated part of this wire was 10 mm and the duration of RF energy; the length of the noninsulated part of this wire 10 mm and the duration of RF supply was 20 seconds. The contralateral normal fallopian tube and uterus were used as a control. All 13 rabbits were randomly sacrificed on two days (group I) or 30 days (group II) after the procedure, and tubal patency and histologic change were evaluated. Transcatheter RF electrocautery is though to be a useful method for tubal occlusion. It is simple, safe, and less expensive and might have a role in future female tubal sterilization. (author). 25 refs., 1 tab., 4 figs.

Fallopian tube occlusion by selective transcatheter radiofrequency electrocautery

International Nuclear Information System (INIS)

Oh, Joo Hyeong; Yoon, Yup; Ko, Young Tae; Nam, Duck Ho; Park, Yong Koo

1998-01-01

The purpose of this study is to access the usefulness of transcatheter radiofrequency (RF) electrocautery as a method of nonsurgical tubal occlusion. Using the coaxial technique under fluoroscopic guidance, transvaginal fluoroscopic fallopian tube catheterization was performed in thirteen rabbits. In each rabbit, unilateral tubal ablation was performed using RF electrocautery. A 0.018 inch metallic wire protruding from the microcatheter tip was used as the source of the RF energy; the length of the noninsulated part of this wire was 10 mm and the duration of RF energy; the length of the noninsulated part of this wire 10 mm and the duration of RF supply was 20 seconds. The contralateral normal fallopian tube and uterus were used as a control. All 13 rabbits were randomly sacrificed on two days (group I) or 30 days (group II) after the procedure, and tubal patency and histologic change were evaluated. Transcatheter RF electrocautery is though to be a useful method for tubal occlusion. It is simple, safe, and less expensive and might have a role in future female tubal sterilization. (author). 25 refs., 1 tab., 4 figs

Isolated torsion of the fallopian tube in a menopausal woman and a pre-pubertal girl: two case reports.

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Toyoshima, Masafumi; Mori, Hikaru; Kudo, Kei; Yodogawa, Yuki; Sato, Kazuyo; Kudo, Takako; Igeta, Saori; Makino, Hiromitsu; Shima, Takashi; Matsuura, Rui; Ishigaki, Nobuko; Akagi, Kozo; Takeyama, Yoichi; Iwahashi, Hideki; Yoshinaga, Kosuke

2015-11-17

Isolated torsion of the fallopian tube without an ovarian abnormality is an uncommon event, with an incidence of approximately 1 in 1,500,000 females. Isolated torsion of the fallopian tube occurs mostly in reproductive-aged women, and is thus extremely rare in menopausal women and pre-pubertal girls. In case 1, 63-year-old Japanese woman presented with a 2-day history of acute lower abdominal pain. Menopause occurred at 53 years of age. Pelvic ultrasonography showed an enlarged mass (73 × 47 mm) on the right side of her uterus. An urgent laparoscopy was performed based on a presumptive diagnosis of right ovarian tumor torsion. During the laparoscopy, we noted a black, necrotic, solid tumor arising from the distal end of her right fimbria. Her right fallopian tube was twisted with the tumor, but her right ovary was normal and not involved. A laparoscopic tumorectomy with a right salpingectomy was performed. Her post-operative course was uneventful. In case 2, a 10-year-old Japanese girl presented with a 1-day history of lower abdominal pain associated with nausea and vomiting. Menarche had occurred 2 months earlier. A computed tomography and magnetic resonance imaging examination demonstrated a dilated tubal cystic mass with a normal uterus and bilateral ovaries. An urgent laparoscopy was performed based on a presumptive diagnosis of right fallopian tube torsion. During laparoscopy, her right fallopian tube was noted to be dark red, dilated, and twisted several times. Her right fimbria was necrotic-appearing and could not be preserved. Therefore, a laparoscopic right salpingectomy was performed. A histologic examination revealed ischemic changes with congestion of her right fallopian tube, which was consistent with tubal torsion. She had an uncomplicated post-operative course. We have presented two very rare cases of isolated fallopian tubal torsion. Radiologic interventions, such as computed tomography and magnetic resonance imaging, in addition to

Diet and Physical Activity Change or Usual Care in Improving Progression-Free Survival in Patients With Previously Treated Stage II, III, or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Science.gov (United States)

2018-02-14

Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Mucinous Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Malignant Ovarian Brenner Tumor; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Stage IIA Fallopian Tube Cancer AJCC v6 and v7; Stage IIA Ovarian Cancer AJCC V6 and v7; Stage IIB Fallopian Tube Cancer AJCC v6 and v7; Stage IIB Ovarian Cancer AJCC v6 and v7; Stage IIC Fallopian Tube Cancer AJCC v6 and v7; Stage IIC Ovarian Cancer AJCC v6 and v7; Stage IIIA Fallopian Tube Cancer AJCC v7; Stage IIIA Ovarian Cancer AJCC v6 and v7; Stage IIIA Primary Peritoneal Cancer AJCC v7; Stage IIIB Fallopian Tube Cancer AJCC v7; Stage IIIB Ovarian Cancer AJCC v6 and v7; Stage IIIB Primary Peritoneal Cancer AJCC v7; Stage IIIC Fallopian Tube Cancer AJCC v7; Stage IIIC Ovarian Cancer AJCC v6 and v7; Stage IIIC Primary Peritoneal Cancer AJCC v7; Stage IV Fallopian Tube Cancer AJCC v6 and v7; Stage IV Ovarian Cancer AJCC v6 and v7; Stage IV Primary Peritoneal Cancer AJCC v7; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma

A case report of fallopian tube into inguinal canal in patient with unicorn uretus

Directory of Open Access Journals (Sweden)

Maryam Asgharnia

2014-11-01

Full Text Available Introduction: Presence of the ovary, fallopian tube and uterus within an inguinal canal is a rare condition in women of reproductive age. Case report: In this report we present a 31-year-old female with 5 years primary infertility who was admitted for infertility evaluation. We described a patient with unicornuate uterus without rudimentary horn and the left fallopian tube within the left inguinal canal diagnosed through laparoscopy. Conclusion: The surgeon who works on infertility may encounter such unexpected intraoperative findings, and must call attention to these findings.

General Information About Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Science.gov (United States)

... black women, but have decreased in both groups. Women who have a family history of ovarian cancer and/or certain inherited gene ... ovarian, fallopian tube, and primary peritoneal cancer: Personal history of breast cancer A woman who has had breast cancer has an increased ...

Congenital or torsion-induced absence of Fallopian tubes. Two case reports.

Science.gov (United States)

Paternoster, D M; Costantini, W; Uglietti, A; Vasile, C; Bocconi, L

1998-05-01

Unilateral absence of a uterine tube is an extremely rare finding, for which there are two possible etiopathogenic causes: in some cases it is due to haemorrhage filling of the cavity and its reabsorption as a result of asymptomatic torsion of the uterine tube during adult life, in pediatric age or even during intrauterine life; alternatively, the absence may be congenital, associated with developmental alterations of the mesonephric and paramesonephric ducts. The article presents two cases of fallopian tube absence: a congenital monolateral absence and a tubal torsion during pregnancy. The symptomatology of the torsion of the fallopian tube in pregnancy can be milder than in the classic description with peritoneal reaction and severe clinical alteration. The main risk factors for tubal torsion are: adhesions and inflammatory processes, ovarian cysts, usually of dermoid type, menstrual period, pregnancy, abnormal long mesosalpinx and/or mesovarium, pelvic congestion induced by constipation and disturbed venous blood flow from the adnexa. A congenital defect of the mesonephric duct is followed by a homolateral defect of the paramesonephric duct. The resulting anomaly is characterized by the absence of the uterine tube, uterus-tube angle, kidney and ureter. Partial or total unilateral defects of a paramesonephric duct are more common than aplasia of both ducts. Some authors have suggested that an inadequate blood supply during the descent into the pelvis of the caudal part of the paramesonephric duct might feasibly lead to incomplete tube development.

Giant cell arteritis of fallopian tube.

Science.gov (United States)

Azzena, A; Altavilla, G; Salmaso, R; Vasoin, F; Pellizzari, P; Doria, A

1994-01-01

One case of giant cells arteritis involving tubaric arteries in a postmenopausal woman is described. The patient was 59 years old and presented with asthenia, anemia, fever, weight loss, an abdominal palpable mass and elevated erythrocyte sedimentation rate. Exploratory laparotomy revealed a large ovarian cyst of 14 cm in diameter. Extensive giant cell arteritis, Horton's type, of the small-sizes arteries was found unexpectedly in the fallopian tube of the patient who had had a prior ovariectomy. Giant cell arteritis of the female genital tract is a rare finding in elderly women and may occur as an isolated finding or as part of generalised arteritis.

The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin

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Thomas Meyer

2013-03-01

Full Text Available High grade serous ovarian cancer (HGSC, the most lethal and frequent type of epithelial ovarian cancer (EOC, has poor long term prognosis due to a combination of factors: late detection, great metastatic potential and the capacity to develop resistance to available therapeutic drugs. Furthermore, there has been considerable controversy concerning the etiology of this malignancy. New studies, both clinical and molecular, strongly suggest that HGSC originates not from the surface of the ovary, but from the epithelial layer of the neighboring fallopian tube fimbriae. In this paper we summarize data supporting the central role of fallopian tube epithelium in the development of HGSC. Specifically, we address cellular pathways and regulatory mechanisms which are modulated in the process of transformation, but also genetic changes which accumulate during disease progression. Similarities between fallopian tube mucosa and the malignant tissue of HGSC warrant a closer analysis of homeostatic mechanisms in healthy epithelium in order to elucidate key steps in disease development. Finally, we highlight the importance of the cancer stem cell (CSC identification and understanding of its niche regulation for improvement of therapeutic strategies.

Mucosal Proliferations in Completely Examined Fallopian Tubes Accompanying Ovarian Low-grade Serous Tumors: Neoplastic Precursor Lesions or Normal Variants of Benign Mucosa?

Science.gov (United States)

Wolsky, Rebecca J; Price, Matt A; Zaloudek, Charles J; Rabban, Joseph T

2018-05-01

Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling. Recently, a candidate fallopian tube precursor to ovarian SBT, so-called papillary tubal hyperplasia, was described in advanced stage patients. The current study was designed to identify fallopian tube mucosal proliferations unique to patients with low-grade serous ovarian tumors (serous cystadenoma, SBT, LGSC) and to determine if they may represent precursors to the ovarian tumors. Fallopian tubes were thinly sliced and entirely examined microscopically, including all of the fimbriated and nonfimbriated portions of the tubes, from patients with ovarian serous cystadenoma (35), SBT (61), and LGSC (11) and from a control population of patients with ovarian mucinous cystadenoma (28), mature cystic teratoma (18) or uterine leiomyoma (14). The slides of the fallopian tubes were examined in randomized order, without knowledge of the clinical history or findings in the ovaries or other organs. Alterations of the mucosa of the fallopian tube were classified as type 1: nonpapillary proliferation of cytologically bland tubal epithelium exhibiting crowding, stratification, and/or tufting without papillary fibrovascular cores or as type 2: papillary alterations consisting of a fibrovascular core lined by a cytologically bland layer of tubal epithelium. A third abnormality, type 3, consisted of detached intraluminal papillae, buds, or nests of epithelium that

The Regulation of Nitric Oxide Synthase Isoform Expression in Mouse and Human Fallopian Tubes: Potential Insights for Ectopic Pregnancy

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Junting Hu

2014-12-01

Full Text Available Nitric oxide (NO is highly unstable and has a half-life of seconds in buffer solutions. It is synthesized by NO-synthase (NOS, which has been found to exist in the following three isoforms: neuro nitric oxide synthase (nNOS, inducible nitric oxide synthase (iNOS, and endothelial nitric oxide synthase (eNOS. NOS activity is localized in the reproductive tracts of many species, although direct evidence for NOS isoforms in the Fallopian tubes of mice is still lacking. In the present study, we investigated the expression and regulation of NOS isoforms in the mouse and human Fallopian tubes during the estrous and menstrual cycles, respectively. We also measured isoform expression in humans with ectopic pregnancy and in mice treated with lipopolysaccharide (LPS. Our results confirmed the presence of different NOS isoforms in the mouse and human Fallopian tubes during different stages of the estrous and menstrual cycles and showed that iNOS expression increased in the Fallopian tubes of women with ectopic pregnancy and in LPS-treated mice. Elevated iNOS activity might influence ovulation, cilia beats, contractility, and embryo transportation in such a manner as to increase the risk of ectopic pregnancy. This study has provided morphological and molecular evidence that NOS isoforms are present and active in the human and mouse Fallopian tubes and suggests that iNOS might play an important role in both the reproductive cycle and infection-induced ectopic pregnancies.

Selective fallopian tube catheterisation in female infertility: clinical results and absorbed radiation dose

International Nuclear Information System (INIS)

Nakamura, K.; Ishiguchi, T.; Maekoshi, H.; Ando, Y.; Tsuzaka, M.; Tamiya, T.; Suganuma, N.; Ishigaki, T.

1996-01-01

Clinical results of fluoroscopic fallopian tube catheterisation and absorbed radiation doses during the procedure were evaluated in 30 infertility patients with unilateral or bilateral tubal obstruction documented on hysterosalpingography. The staged technique consisted of contrast injection through an intrauterine catheter with a vacuum cup device, ostial salpingography with the wedged catheter, and selective salpingography with a coaxial microcatheter. Of 45 fallopian tubes examined, 35 (78 %) were demonstrated by the procedure, and at least one tube was newly demonstrated in 26 patients (87 %). Six of these patients conceived spontaneously in the follow-up period of 1-11 months. Four pregnancies were intrauterine and 2 were ectopic. This technique provided accurate and detailed information in the diagnosis and treatment of tubal obstruction in infertility patients. The absorbed radiation dose to the ovary in the average standardised procedure was estimated to be 0.9 cGy. Further improvement in the X-ray equipment and technique is required to reduce the radiation dose. (orig.). With 3 figs., 3 tabs

The role of the fallopian tube in ovarian cancer.

Science.gov (United States)

Tone, Alicia A; Salvador, Shannon; Finlayson, Sarah J; Tinker, Anna V; Kwon, Janice S; Lee, Cheng-Han; Cohen, Trevor; Ehlen, Tom; Lee, Marette; Carey, Mark S; Heywood, Mark; Pike, Judith; Hoskins, Paul J; Stuart, Gavin C; Swenerton, Kenneth D; Huntsman, David G; Gilks, C Blake; Miller, Dianne M; McAlpine, Jessica N

2012-05-01

High-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian cancer. Research over the past decade has strongly suggested that "ovarian" HGSC arises in the epithelium of the distal fallopian tube, with serous tubal intraepithelial carcinomas (STICs) being detected in 5-10% of BRCA1/2 mutation carriers undergoing risk-reducing surgery and up to 60% of unselected women with pelvic HGSC. The natural history, clinical significance, and prevalence of STICs in the general population (ie, women without cancer and not at an increased genetic risk) are incompletely understood, but anecdotal evidence suggests that these lesions have the ability to shed cells with metastatic potential into the peritoneal cavity very early on. Removal of the fallopian tube (salpingectomy) in both the average and high-risk populations could therefore prevent HGSC, by eliminating the site of initiation and interrupting spread of potentially cancerous cells to the ovarian/peritoneal surfaces. Salpingectomy may also reduce the incidence of the 2 next most common subtypes, endometrioid and clear cell carcinoma, by blocking the passageway linking the lower genital tract to the peritoneal cavity that enables ascension of endometrium and factors that induce local inflammation. The implementation of salpingectomy therefore promises to significantly impact ovarian cancer incidence and outcomes.

Bilateral primary fallopian tube papillary serous carcinoma in postmenopausal woman: Report of two cases

Directory of Open Access Journals (Sweden)

Dipanwita Nag

2016-01-01

Full Text Available Primary carcinoma of the fallopian tube is rare and accounts for about 0.14-1.8% of all gynecological malignancies. Correct diagnosis is rarely made preoperatively as clinically tubal carcinoma closely resembles ovarian carcinoma. Here, we report two cases of bilateral primary fallopian tube carcinomas. Case 1: A 54-year-old female presented with postmenopausal bleeding, abdominal pain, and pervaginal watery discharge for 10 days. Ultrasonography (USG of pelvis showed endometrial thickening and multiple tiny echogenic foci in omentum suggestive of omental cake. With a provisional diagnosis of endometrial carcinoma, total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy was done. On gross examination, small and rudimentary right ovary was adherent to the fimbrial end of the tube. Left-sided tubo-ovarian mass was present, cut section of which showed yellowish solid area in tubal wall and encroaching on ovarian surface. On histological examination, sections from the fimbrial end of both fallopian tubes showed features of papillary serous adenocarcinoma. Case 2: 70-year-old lady, 15 years postmenopausal presented with gradual onset pain and swelling of abdomen, urinary incontinence since 4 days. USG showed bulky uterus, 5 cm × 2 cm fibroid, bilateral tubes, and ovaries were not visualized. Serum cancer antigen-125 was raised (159.7 U/ml. Total hysterectomy and bilateral salpingo-oophorectomy with infracolic omentectomy was done. On gross examination, ovaries were firmly attached to tubes and no apparent solid area was noted. On microscopy, papillary serous adenocarcinoma arising from tubal wall was seen infiltrating focally into ovarian stroma; tubal epithelium showed dysplastic change. Sections from omentum showed numerous psammoma bodies.

Serous Tubal Intraepithelial Carcinoma or Not? Metastases to Fallopian Tube Mucosa Can Masquerade as In Situ Lesions.

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Singh, Reena; Cho, Kathleen R

2017-10-01

- Nonuterine high-grade serous carcinomas (HGSCs) are believed to arise most often from precursors in the fallopian tube referred to as serous tubal intraepithelial carcinomas (STICs). A designation of tubal origin has been suggested for all cases of nonuterine HGSC if a STIC is identified. - To highlight that many different types of nongynecologic and gynecologic carcinomas, including HGSC, can metastasize to the tubal mucosa and mimic de novo STIC. - A mini-review of several recently published studies that collectively examine STIC-like lesions of the fallopian tube. - The fallopian tube mucosa can be a site of metastasis from carcinomas arising elsewhere, and pathologists should exercise caution in diagnosing STIC without first considering the possibility of metastasis. Routinely used immunohistochemical stains can often be used to determine if a STIC-like lesion is tubal or nongynecologic in origin. In the context of uterine and nonuterine HGSC, STIC may represent a metastasis rather than the site of origin, particularly when widespread disease is present.

Fluoroscopically guided fallopian tube recanalization with a simplified set of instruments

International Nuclear Information System (INIS)

Schmitz-Rode, T.; Guenther, R.W.; Neulen, J.

2004-01-01

Purpose: Fluoroscopically guided transcervical fallopian tube recanalization is recognized as an important step in the workup of female infertility. In the present study, a simplified set of recanalization instruments was tested. Materials and Methods: Forty-two women with infertility and sonographically confirmed or suspected uni- or bilateral tubal occlusion were examined. After vaginal placement of a plastic speculum and fixation of a tenaculum, a 4F glide catheter with a 0.89 mm glidewire was advanced transcervically. After documentation of tubal occlusion by hysterosalpingography, the uterotubal junction was catheterized with the same instruments. Under fluoroscopic guidance, the glidewire was negotiated beyond the intramural portion of the tube. Selective salpingography documented the outcome of the recanalization. Results: Hysterosalpingography confirmed tubal occlusions in 26 of 42 patients (in 12 cases unilateral and in 14 cases bilateral). Fallopian tube recanalization was successful in 23 of 26 patients (technical success rate of 88%). The resulting fertility rate was 30% (7/23), without any ectopic pregnancy. Complications such as tubal perforation, infection, or bleeding did not occur. Tubal catheterization was straightforward and smooth in 17/23 cases. For a hyperflexed uterus (6/23), a curved tip of the catheter was helpful in tubal probing. (orig.)

Fallopian Tube Herniation: An Unusual Complication of Surgical Drain

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Sharma, Lipi; Singh, Alpana; Bhaskaran, Sruthi; Radhika, A. G.; Radhakrishnan, Gita

2012-01-01

Background. Surgical drains have been used since time immemorial, but their use is not without complications. By presenting this case we aim to describe an uncommon complication of herniation of fallopian tube following the simple procedure of surgical drain removal. Case Presentation. This case describes a 23-year G2P1L1 who underwent an emergency cesarean section for obstructed labor with intraperitoneal drain insertion. The patient had an uneventful postoperative period, drain was removed ...

Sprouting angiogenesis in human midterm uterus and fallopian tube is guided by endothelial tip cells.

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Rusu, M C; Motoc, A G M; Pop, F; Folescu, R

2013-01-01

Five samples of human midterm fetal uterus and fallopian tube (four donor bodies) were used to assess whether or not processes of angiogenesis are guided by endothelial tip cells (ETCs), and if cytokine-receptors, such as CD117/c-kit and PDGFR-α, are expressed in the microenvironment of the endothelial tubes. CD34 labeled microvessels in the uterine wall (myometrium and endometrium) and in the wall of the uterine (fallopian) tube, and accurately identified ETCs in both organs. We conclude that sprouting angiogenesis in the developing human female tract is guided by ETCs. Moreover, CD117/c-kit antibodies labeled mural networks of pericytes, α-SMA-positive and desmin-negative, related to the endometrial (but not myometrial) microvessels, and similar labeling was identified in the wall of the uterine tube. PDGFR-α positive labeling, stromal and pericytary, was also found. Thus, sprouting angiogenesis in human fetal genital organs appears to be guided by tip cells and is influenced by tyrosine kinase receptor signaling.

Isolated torsion of the fallopian tube in a menopausal woman and a pre-pubertal girl: two case reports

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Toyoshima, Masafumi; Mori, Hikaru; Kudo, Kei; Yodogawa, Yuki; Sato, Kazuyo; Kudo, Takako; Igeta, Saori; Makino, Hiromitsu; Shima, Takashi; Matsuura, Rui; Ishigaki, Nobuko; Akagi, Kozo; Takeyama, Yoichi; Iwahashi, Hideki; Yoshinaga, Kosuke

2015-01-01

Introduction Isolated torsion of the fallopian tube without an ovarian abnormality is an uncommon event, with an incidence of approximately 1 in 1,500,000 females. Isolated torsion of the fallopian tube occurs mostly in reproductive-aged women, and is thus extremely rare in menopausal women and pre-pubertal girls. Case presentations In case 1, 63-year-old Japanese woman presented with a 2-day history of acute lower abdominal pain. Menopause occurred at 53?years of age. Pelvic ultrasonography ...

Application of radionuclide imaging in grading and therapeutic evaluation in patients with fallopian tube dysfunction

International Nuclear Information System (INIS)

Liu Zhixiang; Zhang Yanhua; Li Guangzhou; Zhang Peisen; Xie Hai; Sun Tao; Ren Chun'e; Zhang Shizhuang; Jiang Aifang

2012-01-01

Objective: To observe the conception status of patients with fallopian tube dysfunction after medical treatment and to guide treatment strategy for patients with different degrees of tubal injury by radionuclide imaging. Methods Six hundred and two patients with at least one side of patent fallopian tube underwent modified fallopian tube radionuclide imaging. The patients were graded as: mild, moderate or severe injury, non-functioning or tubal obstruction. The conception status was analyzed after medical treatment, including abdominal hot pack with Chinese medicine, oral intake of Guizhi tuckahoe capsules,and Kangfu anti-inflammatory anal suppository. The constituent ratios of conception in different groups were compared using χ 2 test and the curative and effective rates were calculated. Results: After 1-6 cycles of medical treatment,patients with fallopian tube dysfunction had a curative rate of 29.5% (46/156) and effective rate of 71.8% (112/156). There was a statistically significant difference among the different degrees of oviduct injury (χ 2 =166.4, P<0.05). After medical treatment,the natural pregnancy rate for patients with bilateral mild, moderate and severe injury was 52.6% (102/194), 42.6% (46/108) and 13.8% (16/116), respectively. The rate for patients with one side of normal tubal function was 78.3% (144/184), which was significantly higher than that of patients with bilateral mild, moderate and severe injury (χ 2 =37.86, 52.09 and 121.71, all P<0.05). The natural pregnancy rates of both mild and moderate injury groups were significantly different from the severe injury group (χ 2 =67.29, 42.82, both P<0.05), but there was no difference between the mild and moderate injury groups (χ 2 =3.29, P>0.05). In the severe injury group, 32.8% (38/116) patients were naturally infertile after the medical treatment, while 53.4% (62/116) patients underwent in vitro fertilization (IVF) and 51.6% (32/62) of them succeeded in pregnancy. Conclusions: The natural

Morphology of human Fallopian tubes after infection with Mycoplasma genitalium and Mycoplasma hominis--in vitro organ culture study

DEFF Research Database (Denmark)

Baczynska, Agata; Funch, P; Fedder, J

2007-01-01

BACKGROUND: Female infertility can be caused by scarring and occlusion of the Fallopian tubes. Sexually transmitted bacteria can damage the delicate epithelial layer of human Fallopian tubes (HFT). Genital mycoplasmas are associated with human reproductive failure. Yet, there is not enough evidence...... that mycoplasmas can cause tubal factor infertility. We analysed the effects of infections with Mycoplasma hominis and Mycoplasma genitalium on the HFT epithelium and compared them with the effects of infections with genital pathogens: Chlamydia trachomatis and Neisseria gonorrhoeae. METHODS: We used an in vitro...

Which mode and potency of electrocoagulation yields the Smallest Unobstructed Area of the Fallopian Tubes?

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Campagnolo, Marcelo Ivo; Reis, Ricardo Dos; Santos, Marcele Oliveira Dos; Kliemann, Lúcia Maria; Savaris, Ricardo Francalacci

2018-05-29

 To determine which mode and potency of electrocoagulation, using a modern electrosurgical generator, yields the smallest unobstructed area of the Fallopian tubes.  In an experimental study, tubes from 48 hysterectomies or tubal ligation were evaluated. Tubes were randomly allocated to one of the following groups: group A) 25 W x 5 seconds ( n  = 17); group B) 30 W x 5 seconds ( n  = 17); group C) 35 W x 5 seconds ( n  = 18), group D) 40 W x 5 seconds ( n  = 20); group E) 40 W x 5 seconds with visual inspection (blanch, swells, collapse) ( n  = 16); group F) 50 W x 5 seconds ( n  = 8). Bipolar electrocoagulation was performed in groups A to E, and monopolar electrocoagulation was performed in group F. Coagulation mode was used in all groups. Digital photomicrography of the transversal histological sections of the isthmic segment of the Fallopian tube were taken, and the median percentage of unobstructed luminal area (mm 2 ) was measured with ImageJ software (ImageJ, National Institutes of Health, Bethesda, MD, USA). The Kruskal-Wallis test or analysis of variance (ANOVA) was used for statistical analysis.  Ninety-six Fallopian tube sections were analyzed. The smallest median occluded area (%; range) of the Fallopian tube was obtained in the group with 40 W with visual inspection (8.3%; 0.9-40%), followed by the groups 25 W (9.1%; 0-35.9%), 40 W (14.2; 0.9-43.2%), 30 W (14.2; 0.9-49.7%), 35 W (15.1; 3-46.4%) and 50 W (38.2; 3.1-51%). No statistically significant difference was found among groups ( p  = 0.09, Kruskal-Wallis test).  The smallest unobstructed area was obtained with power setting at 40 W with visual inspection using a modern electrosurgical generator. However, no statistically significant difference in the unobstructed area was observed among the groups using these different modes and potencies. Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil.

Acute abdomen due to ovarian congestion caused by coiling of the fallopian tube accompanied by paratubal cyst around the utero-ovarian ligament.

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Kim, Juyoung; Park, Daehyun; Han, Won Bo; Jeong, Hyangjin; Park, Youngse

2014-07-01

Torsion of uterine adnexa is an important cause of acute abdominal pain in females. The main organ which can cause torsion is the ovaries, but torsions of the fallopian tube, subserosal myoma, paratubal cyst, and even the uterine body have been reported. The incidence of isolated fallopian tubal torsion is very rare. Even more rarely, it can coil around nearby organs such as the utero-ovarian ligament, showing similar clinical manifestations with those of adnexal torsion. We experienced an extremely rare case of acute abdomen induced by ovarian congestion triggered by the fallopian tube accompanying a paratubal cyst coiling around the utero-ovarian ligament. The right paratubal cyst was misinterpreted as being part of a cystic component of the left ovary on preoperative sonographic examination, and the coiling of the right fallopian tube accompanying the paratubal cyst was misdiagnosed as torsion of the right ovary. We report this rare case with a brief literature review.

Pseudocarcinomatous hyperplasia of the fallopian tube mimicking tubal cancer: a radiological and pathological diagnostic challenge.

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Lee, Nam Kyung; Choi, Kyung Un; Han, Ga Jin; Kwon, Byung Su; Song, Yong Jung; Suh, Dong Soo; Kim, Ki Hyung

2016-11-14

Pseudocarcinomatous hyperplasia of the fallopian tube is a rare, benign disease characterized by florid epithelial hyperplasia. The authors present the history and details of a 22-year-old woman with bilateral pelvic masses and a highly elevated serum CA-125 level (1,056 U/ml). Ultrasonography and magnetic resonance imaging (MRI) of the pelvis showed bilateral adnexal complex cystic masses with a fusiform or sausage-like shape. Contrast-enhanced fat-suppressed T1-weighted images showed enhancement of papillary projections of the right adnexal mass and enhancement of an irregular thick wall on the left adnexal mass, suggestive of tubal cancer. Based on MRI and laboratory findings, laparotomy was performed under a putative preoperative diagnosis of tubal cancer. The final pathologic diagnosis was pseudocarcinomatous hyperplasia of tubal epithelium associated with acute and chronic salpingitis in both tubes. The authors report a rare case of pseudocarcinomatous hyperplasia of the fallopian tubes mimicking tubal cancer.

Therapeutic value of selective salpingography for infertile women with patent fallopian tubes: the impact on pregnancy rate.

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Kamiyama, S; Miyagi, H; Kanazawa, K

2000-01-01

To determine the therapeutic value of selective salpingography (SSG) for infertile women with patent fallopian tubes. Retrospective, case-control analysis. University Hospital, infertility clinic. Infertile cases with patent tubes documented by hysterosalpingography (HSG) or by HSG followed by laparoscopic examination (n = 80). Hysteroscopic SSG. Patency rate of tubes by SSG. Pregnancy rate following SSG. Eighty cases were divided into the study group (SSG performed, 37 cases) and the case-control group (SSG not performed, 43 cases). Successful SSG of at least one tube was obtained in all of 37 cases (100%) in whom SSG was attempted. A patency rate of 95.9% was documented in the 73 cannulated tubes of these cases. The total subsequent pregnancy rate (48.6%) within 12 months of follow-up after SSG was significantly higher than that (11.6%) obtained in the control group (p women, either as a sole therapeutic approach or in association with other methods of assisted reproductive technology, even if their fallopian tubes are shown to be patent by HSG. Copyright 2000 S. Karger AG, Basel

Multispectral fluorescence imaging of human ovarian and Fallopian tube tissue for early stage cancer detection

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Tate, Tyler; Baggett, Brenda; Rice, Photini; Watson, Jennifer; Orsinger, Gabe; Nymeyer, Ariel C.; Welge, Weston A.; Keenan, Molly; Saboda, Kathylynn; Roe, Denise J.; Hatch, Kenneth; Chambers, Setsuko; Black, John; Utzinger, Urs; Barton, Jennifer

2015-03-01

With early detection, five year survival rates for ovarian cancer are over 90%, yet no effective early screening method exists. Emerging consensus suggests that perhaps over 50% of the most lethal form of the disease, high grade serous ovarian cancer, originates in the Fallopian tube. Cancer changes molecular concentrations of various endogenous fluorophores. Using specific excitation wavelengths and emissions bands on a Multispectral Fluorescence Imaging (MFI) system, spatial and spectral data over a wide field of view can be collected from endogenous fluorophores. Wavelength specific reflectance images provide additional information to normalize for tissue geometry and blood absorption. Ratiometric combination of the images may create high contrast between neighboring normal and abnormal tissue. Twenty-six women undergoing oophorectomy or debulking surgery consented the use of surgical discard tissue samples for MFI imaging. Forty-nine pieces of ovarian tissue and thirty-two pieces of Fallopian tube tissue were collected and imaged with excitation wavelengths between 280 nm and 550 nm. After imaging, each tissue sample was fixed, sectioned and HE stained for pathological evaluation. Comparison of mean intensity values between normal, benign, and cancerous tissue demonstrate a general trend of increased fluorescence of benign tissue and decreased fluorescence of cancerous tissue when compared to normal tissue. The predictive capabilities of the mean intensity measurements are tested using multinomial logistic regression and quadratic discriminant analysis. Adaption of the system for in vivo Fallopian tube and ovary endoscopic imaging is possible and is briefly described.

Acute abdomen due to ovarian congestion: a fallopian tube accompanied by a paratubal cyst, coiling tightly round the ovary.

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Kaido, Yoshitaka; Kikuchi, Akihiko; Kanasugi, Tomonobu; Fukushima, Akimune; Sugiyama, Toru

2013-01-01

We experienced an unreported rare case with an adnexal mass causing severe acute abdomen during pregnancy. A 30-year-old Japanese pregnant woman was transported to our hospital for her right lower abdominal pain at 30 weeks of gestation. Magnetic resonance imaging and ultrasound demonstrated a cyst measuring 3-4 cm in diameter adjacent to the right ovary, and a parovarian cyst was considered to be the most probable diagnosis. We strongly suspected torsion of the ovarian pedicle or fallopian tube in conjunction with her clinical symptoms. Laparotomy revealed that the elongated right fallopian tube accompanied by a paratubal cyst was coiling tightly 2.5 times round the right ovary, causing apparent congestion and enlargement of the right ovary. Soon after we released the congested right ovary from the coiling of the fallopian tube, the congestion subsided. The postoperative course was favorable, and pregnancy and delivery were uneventful. © 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.

Sex steroid receptors profiling is influenced by nandrolone decanoate in the ampulla of the fallopian tube: Post-treatment and post-recovery analyses.

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Andrade, G H B; Simão, V A; Souza, B R; Chuffa, L G A; Camargo, I C C

2018-02-01

Anabolic androgenic steroids (AAS) are recommended for therapeutic clinic, but their use has increased in recent decades for aesthetic reasons. No study has evaluated the impact of AAS in the fallopian tube, after treatment and recovery periods. Herein, the aim of study was to investigate the effects of Nandrolone Decanoate (ND), administered in different doses (1.87; 3.75; 7.5 and 15 mg/kg) on the ampulla of the fallopian tube in rats, following post-treatment (PT; 15 consecutive days) and post-recovery (PR; 30 consecutive days) periods. The control group received mineral oil. Estrous cycle was monitored daily during both periods and in sequence the rats (n = 8/group/period) were killed. All ND-treated animals showed estral acyclicity during the PT and PR periods, but the histomorphometric changes in the fallopian tube varied according to the ND dose level. The expression of AR, ERα and ERβ varied in the nucleus and cytoplasm of epithelial cells. No AR expression was observed in the stroma. The muscle cells exhibited variation in immunostaining. In conclusion, ND promoted histomorphometric and immunohistochemical changes in the ampullary portion of the fallopian tube after treatment and recovery periods in a dose-independent manner. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Rare Complication of Abdominal Drain: Fallopian Tube Herniation Through the Drain Site

OpenAIRE

Dilek Uygur; Seval Erdinç; Hülya Dede; Ümit Taşdemir; Oktay Kaymak; Nuri Danışman

2016-01-01

Prophylactic drainage of the peritoneal cavity after obstetrical and gynecological surgery is widely practiced. The idea of “when in doubt, drain” is accepted and applied clinically by many surgeons. However, surgically placed drains are not without risk. The present case describes herniation of fallopian tube during the removal of a surgical drain placed after a cesarean section.

SPONTANEOUS FALLOPIAN TUBE EVISCERATION IN PROCIDENTIA AND PERFORATING CARCINOMATOUS VAGINAL WALL ULCER – CASE REPORT

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Marijan Lužnik

2018-02-01

Full Text Available Background. Total prolapse of female pelvic organs is not only painful and troublesome because of difficulties with micturition and defecation but it could be very dangerous since prolapsed vagina presents a predilection area for ulcer and/or rupture of different etiology and with evisceration of abdominal content. Eviscerations usually occur rarely, but when they do occur, it is important to intervene quickly. Most frequent is the evisceration of small bowel, rarely omentum and sporadically other abdominal structures. Neither in literature nor on the internet there were not any examples of primary eviscerated fallopian tube which was not a consequence of preceeding gynecological-surgical procedure found. Methods. 77-year-old woman was appointed to our out patient department with diagnosis of Prolapsus uteri totalis and Dolores abdominalis. In history there was prevulvar bulge in the size of an apple, which persisted for 20 years, and almost disappeared when lying supine. Three days before admission to the hospital the bulge was exceedingly enlarged by straining and did not diminish when lying supine. The patient walked only hardly and could not sit. Micturition and defecation was possible only in the upright position. There were also difficulties while placing the patient on a gynecologic chair, because between her legs there was a bulge in the size of 14 × 10 × 9 cm3 with fallopian tube hanging out (Figure 1. On the outermost part of total uterovaginal prolapse the outer ostium of the cervical canal was recognizable. The bulge was fully stretched, painful and unreponible. Around a hole where a fallopian tube exits, vagina was eritematous, rough folded – swollen and vulnerable (Figure 2. In outpatient department eviscerated fallopian tube and prolapsed vagina with its contents were aseptically treated and Dalacin and Orho Gynest crème were applicated. Foley catheter was inserted. Prolapsed vagina with uterus and other contents remained

Histopathologic changes in fallopian tubes subsequent to sterilization procedures.

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Stock, R J

1983-01-01

Longitudinal serial and serial step sections of fallopian tubes from more than 100 patients, subsequent to tubal sterilization procedures, were examined. Thirteen of these patients had pregnancies following their sterilizations. The histologic findings at the previous surgical sites were compatible with what would be expected for a normal healing process. Evidence for a unique tubal epithelial process, as suggested by the terms "endosalpingiosis" or "recanalization," was lacking. Likewise, the author found no evidence of tuboperitoneal fistula formation and/or the subsequent occurrence of pregnancy secondary to localized endometriosis. The histologic notations of proximal luminal dilatation, plical attenuation, chronic inflammatory infiltrates with pseudopolyp formation, and the findings of plical thickening in the distal segment of remaining tube after an interruption type of procedure seem to be associated with the length of time from the sterilization procedure. These may be factors related to the apparent reduced success rate, with time, of microsurgical reanastomotic procedures.

Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube.

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Yang, Junzheng; Zhou, Yilan; Ng, Shu-Kay; Huang, Kuan-Chun; Ni, Xiaoyan; Choi, Pui-Wah; Hasselblatt, Kathleen; Muto, Michael G; Welch, William R; Berkowitz, Ross S; Ng, Shu-Wing

2017-06-17

Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is involved in the early stages of ovarian cancer pathogenesis by studying the expression levels of the pathway components in a panel of clinical ovarian tissues, and fallopian tube tissues harboring serous tubal intraepithelial carcinomas (STICs), a suggested precursor lesion for high-grade serous tumors. RNA prepared from ovarian and fallopian tube epithelial and stromal fibroblasts was subjected to quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR) to determine the expression of miR-200 families, target and effector genes and analyzed for clinical association. The effects of exogenous miR-200 on marker expression in normal cells were determined by qRT-PCR and fluorescence imaging after transfection of miR-200 precursors. Ovarian epithelial tumor cells showed concurrent up-regulation of miR-200, down-regulation of the four target genes (ZEB1, ZEB2, TGFβ1 and TGFβ2), and up-regulation of effector genes that were negatively regulated by the target genes. STIC tumor cells showed a similar trend of expression patterns, although the effects did not reach significance because of small sample sizes. Transfection of synthetic miR-200 precursors into normal ovarian surface epithelial (OSE) and fallopian tube epithelial (FTE) cells confirmed reduced expression of the target genes and elevated levels of the effector genes CDH1, CRB3 and EpCAM in both normal OSE and FTE cells. However, only FTE cells had a specific induction of CA125 after miR-200 precursor transfection. The activation of the miR-200 pathway may be an early event that renders the OSE and FTE cells more susceptible to oncogenic mutations and histologic differentiation. As high

A Rare Complication of Abdominal Drain: Fallopian Tube Herniation Through the Drain Site

Directory of Open Access Journals (Sweden)

Dilek Uygur

2016-05-01

Full Text Available Prophylactic drainage of the peritoneal cavity after obstetrical and gynecological surgery is widely practiced. The idea of “when in doubt, drain” is accepted and applied clinically by many surgeons. However, surgically placed drains are not without risk. The present case describes herniation of fallopian tube during the removal of a surgical drain placed after a cesarean section.

MV-NIS or Investigator's Choice Chemotherapy in Treating Patients With Ovarian, Fallopian, or Peritoneal Cancer

Science.gov (United States)

2018-04-27

Fallopian Tube Transitional Cell Carcinoma; Malignant Ovarian Clear Cell Tumor; Malignant Ovarian Endometrioid Tumor; Malignant Ovarian Serous Tumor; Ovarian Seromucinous Carcinoma; Ovarian Transitional Cell Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Undifferentiated Fallopian Tube Carcinoma; Undifferentiated Ovarian Carcinoma

Primary carcinoma of fallopian tubes in the material of the Institute of Oncology in Gliwice

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Franek, K; Zielonka, I; Kwasniewska-Rokicinska, C [Instytut Onkologii, Gliwice (Poland)

1976-01-01

The survival of 17 patients treated with postoperative radiotherapy at the Institute of Oncology in Gliwice for primary fallopian tube carcinoma is analysed. The causes of therapeutic failures and short survival (within 2 years) were - too far advanced disease at the time of main treatment which was due to diagnostic difficulties and too late reference of patients for surgery.

Preoperative diagnosis of fallopian tube malignancy with transvaginal color doppler ultrasonography and magnetic resonance imaging after negative hysteroscopy for postmenopausal bleeding.

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Arko, Darja; Žegura, Branka; Virag, Mirjana; Fokter Dovnik, Nina; Takač, Iztok

2014-09-01

Primary fallopian tube carcinoma is a rare malignancy and is not often diagnosed preoperatively. We present a case of a 67-year-old woman who complained of postmenopausal vaginal bleeding. After a negative hysteroscopy, transvaginal ultrasound showed a well vascularized solid-cystic tumor in the adnexal region separate from the ovary. The presence of an adnexal mass was confirmed by MR imaging. Total abdominal hysterectomy with bilateral salpingoophorectomy, omentectomy and appendectomy, as well as pelvic and paraaortic lymphadenectomy was performed. The pathohistological diagnosis was poorly differentiated serous adenocarcinoma of the fallopian tube, FIGO stage IA. The patient was subsequently treated with platinum based adjuvant chemotherapy.

A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development.

Science.gov (United States)

Sherman-Baust, Cheryl A; Kuhn, Elisabetta; Valle, Blanca L; Shih, Ie-Ming; Kurman, Robert J; Wang, Tian-Li; Amano, Tomokazu; Ko, Minoru S H; Miyoshi, Ichiro; Araki, Yoshihiko; Lehrmann, Elin; Zhang, Yongqing; Becker, Kevin G; Morin, Patrice J

2014-07-01

Recent evidence suggests that ovarian high-grade serous carcinoma (HGSC) originates from the epithelium of the fallopian tube. However, most mouse models are based on the previous prevailing view that ovarian cancer develops from the transformation of the ovarian surface epithelium. Here, we report the extensive histological and molecular characterization of the mogp-TAg transgenic mouse, which expresses the SV40 large T-antigen (TAg) under the control of the mouse müllerian-specific Ovgp-1 promoter. Histological analysis of the fallopian tubes of mogp-TAg mice identified a variety of neoplastic lesions analogous to those described as precursors to ovarian HGSC. We identified areas of normal-appearing p53-positive epithelium that are similar to 'p53 signatures' in the human fallopian tube. More advanced proliferative lesions with nuclear atypia and epithelial stratification were also identified that were morphologically and immunohistochemically reminiscent of human serous tubal intraepithelial carcinoma (STIC), a potential precursor of ovarian HGSC. Beside these non-invasive precursor lesions, we also identified invasive adenocarcinoma in the ovaries of 56% of the mice. Microarray analysis revealed several genes differentially expressed between the fallopian tube of mogp-TAg and wild-type (WT) C57BL/6. One of these genes, Top2a, which encodes topoisomerase IIα, was shown by immunohistochemistry to be concurrently expressed with elevated p53 and was specifically elevated in mouse STICs but not in the surrounding tissues. TOP2A protein was also found elevated in human STICs, low-grade and high-grade serous carcinoma. The mouse model reported here displays a progression from normal tubal epithelium to invasive HGSC in the ovary, and therefore closely simulates the current emerging model of human ovarian HGSC pathogenesis. This mouse therefore has the potential to be a very useful new model for elucidating the mechanisms of serous ovarian tumourigenesis, as well as

[The morphological and immunohistochemical characteristics of changes in the fallopian tube mucosa in ovarian epithelial tumors].

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Asaturova, A V; Ezhova, L S; Faizullina, N M; Sannikova, M V; Khabas, G N

2016-01-01

to study the incidence of fallopian tube lesions (secretory cell proliferations (SCP), p53 signature, serous tubal intraepithelial lesions (STIL), and serous tubal intraepithelial carcinomas (STIC) in ovarian epithelial tumors and to propose their pathogenetic association with a certain histotype of the ovarian tumor. The investigation enrolled 136 patients with ovarian epithelial tumors, whose fallopian tubes were morphologically and immunohistochemically (IHC) examined using p53, Ki-67, and PAX2. Statistical analysis was carried out applying the Mann-Whitney test and χ(2) test. Lesions meeting the STIC criteria were found in 14.7% of cases (only in ovarian serous carcinoma (OSC)), those suspecting STICs were in 25.7%, and those without signs of STICs were in 59.6%. IFC examination diagnosed STIC in 10% of cases (only in OSC), STIL in 13.3%, p53 signature in 11.7% (only in serous tumors), and the normal/reactively changed tubal epithelium in 65%. The incidence of STILs correlated with the malignant potential of serous tumors significantly (pSTIC and high-grade OSC and revealed significant differences in the incidence of other fallopian tubal intraepithelial lesions in serous cystadenomas, borderline tumors, and OSC, in different ovarian carcinomas. The findings may suggest that the earliest stage in the pathogenesis of OSC is the development of SCP, followed by the formation of p53 signatures that may further give rise to STIL, and finally STC (due to the acquisition of additional mutations).

Fallopian tube recanalisation using dedicated radiographic tubal assessment set in angiography suite

International Nuclear Information System (INIS)

Al-Omari, M.H; Rousan, L.; Al-balas, H.; Alawneh, K.; El-heis, M.; Al-mnayyis, A.; Obeidat, N.; Amarin, Z.; Zayed, F.; Omari, Z.; Hanania, R.

2014-01-01

Fallopian tube recanalisation (FTR) for proximal fallopian tube obstruction (PFTO) is considered a good treatment option for tubal infertility. The aim of this study was to assess the safety and the technical and clinical success rates of FTR using a dedicated radiographic tubal assessment set (FluoroSet®) in the angiography suite. This study is a retrospective analysis of data prospectively collected between February 2007 and June 2011 at King Abdullah University Hospital, Irbid, Jordan. During this period, 61 patients affected by PFTO underwent FTR using FluoroSet® at our institution. The mean age of patients was 34 years (range 20-45 years), and the mean duration of infertility was 4 years (range 2-14 years). The procedure was performed with conscious sedation under fluoroscopic guidance in the angiography suite. The obstructed tube was accessed with a 5-Fr multipurpose catheter, and the obstruction was crossed with a 0.35-Fr hydrophilic guide wire until the wire coiled freely into the peritoneal cavity. Patency of the tube was then confirmed by selective salpingiogram. Technical success rate was recorded, and patients were followed up for evidence of pregnancy over 12 months. The procedure was technically successful in all patients. Minor bleeding and postprocedural pain occurred in most patients; however, there were no major complications encountered. Twenty-five patients (41%) became pregnant. Successful deliveries of full-term infants were reported in 21 patients (84%). Miscarriage was reported in four patients (16%). No ectopic pregnancies were detected, and all deliveries were full-term. The technical success rate was 100% and the clinical success rate was 41%. Selective salpingography and FTR using FluoroSet® is a safe and effective method. FTR is recommended as the first intervention in patients with PFTO. In experienced hands with dedicated equipment and in an appropriate setting, the success rate is high, and this treatment should be offered to

Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer

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2018-06-04

Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Stage I Ovarian Cancer; Stage IA Ovarian Cancer; Stage IB Ovarian Cancer; Stage IC Ovarian Cancer; Stage II Ovarian Cancer; Stage IIA Ovarian Cancer; Stage IIB Ovarian Cancer; Stage IIC Ovarian Cancer; Stage III Ovarian Cancer; Stage IIIA Ovarian Cancer; Stage IIIB Ovarian Cancer; Stage IIIC Ovarian Cancer; Stage IV Ovarian Cancer

Drain site evisceration of fallopian tube, another reason to discourage abdominal drain: report of a case and brief review of literature.

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Saini, Pradeep; Faridi, M S; Agarwal, Nitin; Gupta, Arun; Kaur, Navneet

2012-04-01

Placement of a drain following abdominal surgery is common despite a lack of convincing evidence in the current literature to support this practice. The use of intra-abdominal drain is associated with many potential and serious complications. We report a drain site evisceration of the right fallopian tube after the removal of an intra-abdominal drain. The drain was placed in the right iliac fossa in a patient who underwent a lower segment Caesarean section (LSCS) for meconium liquor with fetal distress. The Pfannenstiel incision made for LSCS was reopened and the protruding inflamed fimbrial end of the right fallopian tube was excised. The patient made an uneventful recovery. Routine intra-abdominal prophylactic drain following an abdominal surgery including LSCS should be discouraged.

The comparison between Intrauterine Insemination and Fallopian Tube Sperm Perfusion Using FAST® System in Patients with Unexplained Infertility

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Sepideh Peivandi

2015-02-01

Full Text Available Background: Controlled ovarian stimulation (COH with intrauterine insemination (IUI is commonly offered to infertile couples with patent fallopian tubes because it is simple, non-invasive and cost-effective technique. Another non-invasive method is fallopian tube sperm perfusion (FSP. This study was performed to compare the relative efficacy between FSP using fallopian sperm transfer (FAST system and standard IUI in patients with unexplained infertility. Materials and Methods: This prospective randomized study was conducted at the IVF Unit, Department of Gynecology and Obstetrics, Mazandaran University of Medical Sciences, Sari, Iran, from March 2011 to February 2012. A total of ninety patients with unexplained infertility underwent ovarian stimulation with clomiphene citrate and human menopausal gonadotropin (HMG. Patients were then randomly assigned into either group I (n=45 to undergo standard IUI or group II (n=45 to undergo FSP using FAST system. Results: The patients’ basic characteristics, including age, primary infertility and duration of infertility, were not significantly different between two study groups. In the group I, there were 9 pregnancies (a pregnancy rate per cycle of 20%, whereas in the group II, 8 pregnancies occurred (a pregnancy rate per cycle of 17.8%, p>0.05. Conclusion: FSP using FAST system offers no advantage over the standard IUI in order to increase pregnancy rate in patients with unexplained infertility.

Fluoroscopically guided fallopian tube recanalization with a simplified set of instruments; Durchleuchtungsgesteuerte Eileiter-Rekanalisation mit vereinfachtem Instrumentarium

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Schmitz-Rode, T.; Guenther, R.W. [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Neulen, J. [Technische Hochschule Aachen (Germany). Frauenklinik fuer gynaekologische Endokrinologie und Reproduktionsmedizin

2004-10-01

Purpose: Fluoroscopically guided transcervical fallopian tube recanalization is recognized as an important step in the workup of female infertility. In the present study, a simplified set of recanalization instruments was tested. Materials and Methods: Forty-two women with infertility and sonographically confirmed or suspected uni- or bilateral tubal occlusion were examined. After vaginal placement of a plastic speculum and fixation of a tenaculum, a 4F glide catheter with a 0.89 mm glidewire was advanced transcervically. After documentation of tubal occlusion by hysterosalpingography, the uterotubal junction was catheterized with the same instruments. Under fluoroscopic guidance, the glidewire was negotiated beyond the intramural portion of the tube. Selective salpingography documented the outcome of the recanalization. Results: Hysterosalpingography confirmed tubal occlusions in 26 of 42 patients (in 12 cases unilateral and in 14 cases bilateral). Fallopian tube recanalization was successful in 23 of 26 patients (technical success rate of 88%). The resulting fertility rate was 30% (7/23), without any ectopic pregnancy. Complications such as tubal perforation, infection, or bleeding did not occur. Tubal catheterization was straightforward and smooth in 17/23 cases. For a hyperflexed uterus (6/23), a curved tip of the catheter was helpful in tubal probing. (orig.)

In vitro assessment of some sperm function following exposure to levonorgestrel in human fallopian tubes

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Hermanny Alexia

2012-01-01

Full Text Available Abstract Background The mechanism of action of levonorgestrel (LNG as emergency contraception (EC remains a subject of debate and its effect on sperm function has been only partially explained. The aim of this study was to assess whether LNG at a similar dose to those found in serum following oral intake for EC could affect spermatozoa when exposed to human fallopian tubes in vitro. Methods Fifteen mini-laparotomies were performed, the side on which ovulation occurred was recorded, and both tubes were removed and perfused with a suspension containing 1 × 10(6 motile spermatozoa, with or without LNG. Following 4-hour incubation, the tubes were sectioned to separate the isthmus and the ampulla. Each segment was flushed and the material was evaluated to quantify the number of motile sperm, the number of spermatozoa adhering to the oviductal epithelium and the acrosome reaction (AR rate. Results The addition of LNG did not significantly alter the number of recovered motile spermatozoa either at the isthmus or at the ampulla, nor did it have any effect on the number of recovered spermatozoa adhered to the human tubal epithelium. Furthermore, LNG did not affect the AR rate. No significant differences were found even when the side on which ovulation occurred was taken into account. Conclusions In a similar dose to that observed in serum following oral intake for EC, LNG had no effect on the number of motile spermatozoa recovered from the human fallopian tubes in vitro, on their adhesion to the tubal epithelium, distribution or AR rate. The possible effect of LNG as EC on sperm function remains poorly understood.

Management of advanced-stage primary carcinoma of the fallopian tube: case report and literature review.

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Kuscu, E; Oktem, M; Haberal, A; Erkanli, S; Bilezikci, B; Demirhan, B

2003-01-01

Primary carcinoma of the fallopian tube is a very unusual gynecologic malignancy that accounts for less than 1% of all malignancies of the female genitalia. A 55-year-old, gravida 7, para 3 woman presented with no gynecologic complaints other than backache. TVS demonstrated a 35 x 25 mm heterogeneous mass that was not clearly separated from the left ovary, and another 31 x 14 mm cystic septated lesion in the left ovary region. Pelvic MRI demonstrated a 35 x 35 x 20 mm left adnexal mass that enhanced with contrast and a neighboring tubular-cystic mass. Upper and lower gastrointestinal endoscopy revealed no malignancy. Serum CA 125-level was merkedly elevated at 369 U/ml (normal serous adenocarcinoma. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, appendectomy, omentectomy, pelvic and para-aortic lymph node dissection, and peritoneal washing were performed. The definitive histopathological diagnosis was primary serous adenocarcinoma of the fallopian tube with six of 25 lymph node biopsies showing metastasis. Six cycles of paclitaxel (175 mg/m2) plus cisplatin (75 mg/m2) combinatin chemotherapy were administered with 3-week intervals between cycles. Second-look laparotomy was performed; there was no evidence of disease. At the time of writing 12 months after the second-look laparotomy, she was still disease-free.

Fallopian tube intraluminal tumor spread from noninvasive precursor lesions: a novel metastatic route in early pelvic carcinogenesis.

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Bijron, Jonathan G; Seldenrijk, Cornelis A; Zweemer, Ronald P; Lange, Joost G; Verheijen, René H M; van Diest, Paul J

2013-08-01

Pelvic serous carcinoma is usually advanced stage at diagnosis, indicating that abdominal spread occurs early in carcinogenesis. Recent discovery of a precursor sequence in the fallopian tube, culminating in serous tubal intraepithelial carcinoma (STIC), provides an opportunity to study early disease events. This study aims to explore novel metastatic routes in STICs. A BRCA1 mutation carrier (patient A) who presented with a STIC and tubal intraluminal shedding of tumor cells upon prophylactic bilateral salpingo-oophorectomy (PBSO) instigated scrutiny of an additional 23 women who underwent a PBSO and 40 patients with pelvic serous carcinoma involving the tubes. Complete serial sectioning of tubes and ovaries of patient A did not reveal invasive carcinoma, but subsequent staging surgery showed disseminated abdominal disease. STIC, intraluminal tumor cells, and abdominal metastases displayed an identical immunohistochemical profile (p53/WT1/PAX8/PAX2) and TP53 mutation. In 16 serous carcinoma patients (40%) tubal intraluminal tumor cells were found, compared with none in the PBSO group. This is the first description of a STIC, which plausibly metastasized without the presence of invasion through intraluminal shedding of malignant surface epithelial cells in the tube and subsequently spread throughout the peritoneal cavity. These findings warrant a reconsideration of the malignant potential of STICs and indicate that intraluminal shedding could be a risk factor for early intraperitoneal metastasis. Although rare in the absence of invasive cancer, we show that intraluminal shedding of tumor cells in the fallopian tubes from serous carcinoma cases are common and a likely route of abdominal spread.

The fallopian tube-peritoneal junction: a potential site of carcinogenesis.

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Seidman, Jeffrey D; Yemelyanova, Anna; Zaino, Richard J; Kurman, Robert J

2011-01-01

Junctions between different types of epithelia are hot spots for carcinogenesis, but the junction of the peritoneal mesothelium with the fallopian tubal epithelium, the tubal-peritoneal junction, has not been characterized earlier. A total of 613 junctional foci in 228 fallopian tube specimens from 182 patients who underwent surgery for a variety of indications, including 27 risk-reducing salpingo-oophorectomy specimens, were studied. Edema, congestion, and dilated lymphatic channels were commonly present. Transitional metaplasia was found at the junction in 20% of patients and mesothelial hyperplasia in 17%. Inflammation at the junction was seen predominantly in patients with salpingitis, torsion, or tubal pregnancy. Ovarian-type stroma was found at the junction in 5% of patients, and was found elsewhere in the tubal lamina propria in an additional 27% of patients. Findings in risk-reducing salpingo-oophorectomy specimens in women with BRCA mutations, a personal history of breast cancer, and/or a family history of breast/ovarian cancer were similar to those in controls. Transitional metaplasia specifically localizes to this junction, and is the probable source of Walthard cell nests. The recently highlighted significance of fimbrial tubal epithelium in the origin of serous ovarian carcinomas and a study suggesting that mucinous and Brenner tumors may arise from transitional-type epithelium in this location suggest that the tubal-peritoneal junction may play a role in the development of these tumors. This is the first comprehensive description of a hitherto unrecognized transitional zone in the adnexa.

Acute abdomen due to ovarian congestion caused by coiling of the fallopian tube accompanied by paratubal cyst around the utero-ovarian ligament

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Kim, Juyoung; Park, Daehyun; Han, Won Bo; Jeong, Hyangjin; Park, Youngse

2014-01-01

Torsion of uterine adnexa is an important cause of acute abdominal pain in females. The main organ which can cause torsion is the ovaries, but torsions of the fallopian tube, subserosal myoma, paratubal cyst, and even the uterine body have been reported. The incidence of isolated fallopian tubal torsion is very rare. Even more rarely, it can coil around nearby organs such as the utero-ovarian ligament, showing similar clinical manifestations with those of adnexal torsion. We experienced an ex...

Population-based study of survival for women with serous cancer of the ovary, fallopian tube, peritoneum or undesignated origin - on behalf of the Swedish gynecological cancer group (SweGCG).

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Dahm-Kähler, Pernilla; Borgfeldt, Christer; Holmberg, Erik; Staf, Christian; Falconer, Henrik; Bjurberg, Maria; Kjölhede, Preben; Rosenberg, Per; Stålberg, Karin; Högberg, Thomas; Åvall-Lundqvist, Elisabeth

2017-01-01

The aim of the study was to determine survival outcome in patients with serous cancer in the ovary, fallopian tube, peritoneum and of undesignated origin. Nation-wide population-based study of women≥18years with histologically verified non-uterine serous cancer, included in the Swedish Quality Registry for primary cancer of the ovary, fallopian tube and peritoneum diagnosed 2009-2013. Relative survival (RS) was estimated using the Ederer II method. Simple and multivariable analyses were estimated by Poisson regression models. Of 5627 women identified, 1246 (22%) had borderline tumors and 4381 had malignant tumors. In total, 2359 women had serous cancer; 71% originated in the ovary (OC), 9% in the fallopian tube (FTC), 9% in the peritoneum (PPC) and 11% at an undesignated primary site (UPS). Estimated RS at 5-years was 37%; for FTC 54%, 40% for OC, 34% for PPC and 13% for UPS. In multivariable regression analyses restricted to women who had undergone primary or interval debulking surgery for OC, FTC and PPC, site of origin was not independently associated with survival. Significant associations with worse survival were found for advanced stages (RR 2.63, Pcancer at UPS than for ovarian, fallopian tube and peritoneal cancer. Serous cancer at UPS needs to be addressed when reporting and comparing survival rates of ovarian cancer. Copyright © 2016 Elsevier Inc. All rights reserved.

Primary Papillary Serous Carcinoma of the Fallopian Tube Presenting as a Vaginal Mass: A Case Report and Review of the Literature.

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Kadour-Peero, Einav; Sagi-Dain, Lena; Cohen, Gil; Korobochka, Roman; Agbarya, Abed; Bejar, Jacob; Sagi, Shlomi

2018-05-07

BACKGROUND There is now evidence to support that some cases of high-grade serous papillary carcinoma arise from the fallopian tubes rather than the ovaries. Common symptoms at presentation include abdominal pain and swelling, vomiting, altered bowel habit and urinary symptoms. To our knowledge, this is the first case of serous papillary carcinoma presenting as a vaginal mass lesion. CASE REPORT A 41-year-old woman was referred to the Bnai-Zion Medical Center with the main complaint of irregular vaginal bleeding, vaginal mucous discharge, and suspected pelvic mass. Physical examination showed a soft, painless mass, measuring about 10 cm in diameter located mainly in the recto-vaginal septum, but not involving the uterus. Ultrasound examination showed no abnormal ovarian or uterine findings. Transvaginal biopsies of the mass showed a poorly differentiated serous papillary carcinoma of ovarian, tubal, or peritoneal origin. The physical examination and imaging findings strongly indicated an inoperable tumor, and the patient was treated with neoadjuvant (pre-surgical) chemotherapy. Pre-operative computed tomography (CT) imaging showed the partial involvement of the colon, and so surgical treatment included total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, partial vaginectomy, anterior rectal resection, and lymph node dissection. Histopathology of the surgical specimens showed a poorly differentiated serous carcinoma originating from the fimbria of the right fallopian tube. CONCLUSIONS To the best of our knowledge, this is the first report to describe primary fallopian tube papillary serous carcinoma presenting as a vaginal mass. Therefore, physicians should be aware of this possible diagnosis.

Non-destructive controls in the steel tube industry

International Nuclear Information System (INIS)

Mondot, J.

1978-01-01

The main non-destructive control methods in the tube industry are reviewed: eddy currents, particularly well adapted to small tubes; magnetoscopic testing for weldless tubes; ultrasonic waves widely used for thick weldless tubes and weldings; radiography, to examine tube ends and the known questionable zones; measure of diameters by laser [fr

Quality assessment of studies on interventional recanalization of fallopian tube in China

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Lu Liming; Zhou Weisheng; Yan Ying; Zeng Jingchun

2009-01-01

Objective: To evaluate the current status of studies on interventional recanalization of fallopian tube. Methods: According to the standard of evidence-based medicine, literatures were analyzed by two readers in three time periods: 1997 to 2000, 2001 to 2004 and 2005 to 2008. Two separate evaluation results were tested by the statistical method Kappa to test its consistency. Scores of clinical controlled trials (CCT) and randomized controlled trials (RCT) were calculated according to Jadad score scale. The accurate criteria of case selection, case exclusion, and effect determination; the method of randomization; the number of samples; the comparability of baseline; the blinded procedure; the therapeutic method; the method of statistical analysis; the follow-up cases; the drop-out cases and the conclusions derivation of RCT and CCT into descriptive analysis were evaluated. Results: One hundred and fifty seven therapeutic articles were searched and 30 RCT and CCT articles (25 RCT and 5 CCT) were analyzed. The Kappa value was 0.85 and P<0.05 indicating that the evaluation was in good consistency. 2, 15 and 8 RCT received 0 point, 1 point and 2 points respectively in Jadad score scale. RCT and CCT contained 9 articles (30.0%) fulfilled the accurate criteria of case selection and exclusion; 12 articles (40.0%) met the accurate criteria of effect determination; 4 articles (13.3%) utilized the definite method of randomization; 27 articles (90.0%) had the number of sample beyond 60; 14 articles (46.7%) met the baseline comparability; only 1 article (3.3%) used the single-blinded method, 17 articles (56.7%) utilized the method of statistical analysis; 13 (43.3%) mentioned follow-up in articles; 4 (13.3%) mentioned drop-out cases in the articles and 14 (46.7%) articles had the conclusions derived by considering the statistical significance and clinical significance. Conclusion: The quality of studies on interventional recanalization of fallopian tube is poor and could not

Fluoroscopically Guided Transcervical Fallopian Tube Recanalization of Post-Sterilization Reversal Mid-Tubal Obstructions

International Nuclear Information System (INIS)

Houston, J. Graeme; Anderson, David; Mills, John; Harrold, Anthony

2000-01-01

Purpose: To assess the technical success and early outcome of fluoroscopically guided transcervical fallopian tube recanalization (FTR) in mid-tubal occlusion following sterilization reversal surgery.Methods: From July 1995 to January 1998, patients with greater than 12 months secondary infertility underwent hysterosalpingography (HSG). FTR was performed in proximal or mid-tubal occlusion. Cases of FTR in mid-tubal occlusion were included in this study. Technical success (defined as complete tubal patency) using a standard guidewire and hydrophilic glidewire, the number of patients with at least one patent tube, and the intrauterine and ectopic pregnancy rates were determined.Results: Twenty-six infertile patients with previous sterilization reversal underwent HSG. Eight of 26 (31%) patients (mean age 32 years, range 23-37 years), had attempted FTR for mid-tubal occlusion at the site of surgical anastomosis. Fourteen tubes were attempted as there were two previous salpingectomies. Technical success was achieved in eight of 14 (57%) tubes attempted, resulting in five of eight (62%) patients having at least one patent tube. At follow-up (mean 18 months, range 12-28 months) in these five patients there was one intrauterine pregnancy. There were no ectopic pregnancies.Conclusions: FTR in mid-tubal obstruction in infertile patients following sterilization reversal surgery is technically feasible and may result in intrauterine pregnancy. In this small group there was a lower technical success rate and lower pregnancy rate than in unselected proximal tubal occlusion

Interventional ovarian tube catheterization in treating tubal ectopic pregnancy

International Nuclear Information System (INIS)

Hu Yi; Xiong Linhui; Du Pianqin; Chen Jiabin

2004-01-01

Objective: To explore the feasibility and curative effect of treating tubal pregnancy through the fallopian tube with interventional catheterization decrease the difficulty of the procedure and shorten the consuming time. Methods: Applying the method of interventional catheterization of fallopian tube and injecting 0.5 mg atropine at the cervix beforehand, then 70 mg MTX was administered into the fallopian tube. Results: 113 patients were successfully recovered with health except one without any adversary complication. Conclusions: The interventional fallopian tube catheterization for treating ectopic pregnancy is a simple, safe, minitraumatic, quick and effective method. (authors)

Acetyl-L-Carnitine Hydrochloride in Preventing Peripheral Neuropathy in Patients With Recurrent Ovarian Epithelial Cancer, Primary Peritoneal Cavity Cancer, or Fallopian Tube Cancer Undergoing Chemotherapy

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2014-12-29

Fatigue; Malignant Ovarian Mixed Epithelial Tumor; Neuropathy; Neurotoxicity Syndrome; Ovarian Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Pain; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma

The Effect of Low Dose of Lead Acetate on the Fallopian Tubes and the Role of Garlic Extract—A Histomorphic Study on Mouse

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Naureen Waseem

2015-02-01

Full Text Available This study aimed to investigate the effect of lead acetate on the fallopian tube of adult mice and the possible effect of garlic extract in a Laboratory Based Randomized Control Trial. In this study, 30 female BALBc mice were selected and randomly divided into three groups. Ten animals were placed in each group. Group A being the control received only the laboratory diet. Group B was given lead acetate at a dose of 30 mg/kg/day. Group C was given lead acetate at 30 mg/kg/day and garlic extract at 500 mg/kg/day. All treatments were given through oral gavage tube for 60 days. The mice were sacrificed and dissected at the end of 60 days. The fallopian tubes were carefully dissected out and fixed in 10% formalin for routine histological examination. The histological findings in experimental group B showed increase in epithelial height, whereas no such findings were observed in group A and there was slight increase in height in group C. The lead acetate affected the epithelial height in lead acetate treated group which improved when cotreated with garlic extract.

Comparative Study of Laparoscopic Abdominopelvic and Fallopian Tube Findings Before and After Antitubercular Therapy in Female Genital Tuberculosis With Infertility.

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Sharma, Jai Bhagwan; Sneha, Jayaramaiah; Singh, Urvashi B; Kumar, Sunesh; Roy, Kallol Kumar; Singh, Neeta; Dharmendra, Sona; Vanamail, Perumal

2016-02-01

To study the effect of antitubercular treatment (ATT) on the laparoscopic abdominopelvic and fallopian tube findings in female genital tuberculosis (FGBT). Prospective cohort (Canadian Task Force classification II2). Tertiary referral center in northern India. Fifty women with infertility and diagnosed with FGTB on laparoscopy, histopathology findings, or endometrial sampling (acid-fast bacilli culture, granuloma on histopathology, positive polymerase chain reaction). Diagnostic laparoscopy in all women diagnosed with FGTB before and after a 6-month course of ATT (2 months of rifampicin, isoniazid, pyrazinamide, and ethambutol, followed by 4 months of rifampicin and isoniazid). All procedures were performed by the same surgeon between June 2012 and May 2014. The mean patient age was 28.7 years, mean parity was 0.9, and mean body mass index was 23.6 kg/m(2). Infertility was seen in all 50 women (66% primary infertility, 34% secondary infertility), with a mean duration of 6.06 years. Abnormal laparoscopic findings of FGTB included tubercles in the pelvic peritoneum, fallopian tube, and ovary in 27 women (54%) before ATT and in only 1 (2.04%) woman after ATT (p women (8%) before ATT, and in no women after ATT (p right side (56%), left side (50%), and both sides (38%) before ATT. Hydrosalpinx, beaded tubes, and nonvisualized tube were seen in 33.4%, 4.1%, and 20.8% cases, respectively, after ATT; however, free spill increased to 52% on the right side and 50% on left side after ATT. ATT improves laparoscopic findings in FGTB with infertility. However, advanced fibrotic lesions (eg, pelvic and perihepatic adhesions, bilateral blocked tubes) do not improve with ATT. Copyright © 2016 AAGL. Published by Elsevier Inc. All rights reserved.

Advantages and disadvantages of hysterosonosalpingography in the assessment of the reproductive status of uterine cavity and fallopian tubes

International Nuclear Information System (INIS)

Radic, Vanja; Canic, Tomislav; Valetic, Josip; Duic, Zeljko

2005-01-01

Background: Hysterosonosalpingography as a contrast ultrasound method is safer, cheaper and easier to perform than hysterosalpingography in the assessment of the uterine cavity and fallopian tubes. Is it feasible for all patients? Which is the main problem in the evaluation of target structures by ultrasound? Methods: In a prospective study, 68 patients in the initial stage of the infertility treatment were examined by hysterosonosalpingography using saline NaCl infundibile[reg] and Echovist[reg] as contrast media. Subsequently, further status of the tubes and uterine cavity was assessed by the 'gold standards', laparoscopy and hysteroscopy. Results: Sensitivity and specificity of hysterosonosalpingography using NaCl infundibile[reg] for evaluation of the uterine cavity was 100 and 88.8%, respectively. Negative predictive value was 100% and positive predictive value 97%. Sensitivity and specificity of the method for the assessment of the tubal status was 100 and 66%, respectively, negative predictive value was 100% and positive predictive value was 61%. For the assessment of tubal patency using positive contrast Echovist[reg] the method has shown 100% sensibility and negative predictive value again but it reached a specificity of 77% and a positive predictive value of 70%. There were no evident complications during or after the procedure. Conclusion: Hysterosonosalpingography is useful in making decisions regarding further procedures for the diagnosis and treatment of infertility. Uterine cavity evaluation using saline is the method of choice. Tubal patency can be assessed only under ideal sonographic conditions. The method is feasible for early assessment of the reproductive status of uterine cavity and fallopian tubes as a simple, safe and cheap outpatient method prior to any following invasive procedure or even histerosalpingography

Advantages and disadvantages of hysterosonosalpingography in the assessment of the reproductive status of uterine cavity and fallopian tubes

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Radic, Vanja; Canic, Tomislav; Valetic, Josip; Duic, Zeljko

2005-02-01

Background: Hysterosonosalpingography as a contrast ultrasound method is safer, cheaper and easier to perform than hysterosalpingography in the assessment of the uterine cavity and fallopian tubes. Is it feasible for all patients? Which is the main problem in the evaluation of target structures by ultrasound? Methods: In a prospective study, 68 patients in the initial stage of the infertility treatment were examined by hysterosonosalpingography using saline NaCl infundibile[reg] and Echovist[reg] as contrast media. Subsequently, further status of the tubes and uterine cavity was assessed by the 'gold standards', laparoscopy and hysteroscopy. Results: Sensitivity and specificity of hysterosonosalpingography using NaCl infundibile[reg] for evaluation of the uterine cavity was 100 and 88.8%, respectively. Negative predictive value was 100% and positive predictive value 97%. Sensitivity and specificity of the method for the assessment of the tubal status was 100 and 66%, respectively, negative predictive value was 100% and positive predictive value was 61%. For the assessment of tubal patency using positive contrast Echovist[reg] the method has shown 100% sensibility and negative predictive value again but it reached a specificity of 77% and a positive predictive value of 70%. There were no evident complications during or after the procedure. Conclusion: Hysterosonosalpingography is useful in making decisions regarding further procedures for the diagnosis and treatment of infertility. Uterine cavity evaluation using saline is the method of choice. Tubal patency can be assessed only under ideal sonographic conditions. The method is feasible for early assessment of the reproductive status of uterine cavity and fallopian tubes as a simple, safe and cheap outpatient method prior to any following invasive procedure or even histerosalpingography.

Apoptosis related genes expressed in cultured Fallopian tube epithelial cells infected in vitro with Neisseria gonorrhoeae

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PAZ A REYES

2007-01-01

Full Text Available Background: Infection of the Fallopian tubes (FT by Neisseria gonorrhoeae (Ngo can lead to acute salpingitis, an inflammatory condition resulting in damage primarily to the ciliated cells, with loss of ciliary activity and sloughing of the cells from the epithelium. Recently, we have shown that Ngo infection induced apoptosis in FT epithelium cells by a TNF-alpha dependent mechanism that could contribute to the cell and tissue damage observed in gonococcal salpingitis. Aim: To investigate the apoptosis-related genes expressed during apoptosis induction in cultured FT epithelial cells infected in vitro by Ngo. Materials and Methods: In the current study, we used cDNA macroarrays and real time PCR to identify and determine the expression levels of apoptosis related genes during the in vitro gonococci infection of FT epithelial cells. Results: Significant apoptosis was induced following infection with Ngo. Macroarray analysis identified the expression of multiple genes of the TNF receptor family (TNFRSF1B, -4, -6, -10A, -10B and -10D and the Bcl-2 family (BAK1, BAX, BLK, HRK and MCL-1 without differences between controls and infected cells. This lack of difference was confirmed by RT-PCR of BAX, Bcl-2, TNFRS1A (TNFR-I and TNFRSF1B (TNFR-II. Conclusion: Several genes related to apoptosis are expressed in primary cultures of epithelial cells of the human Fallopian tube. Infection with Ngo induces apoptosis without changes in the pattern of gene expression of several apoptosis-related genes. Results strongly suggest that Ngo regulates apoptosis in the FT by post-transcriptional mechanisms that need to be further addressed

Preoperative Diagnosis of Fallopian Tube Malignancy with Transvaginal Color Doppler Ultrasonography and Magnetic Resonance Imaging after Negative Hysteroscopy for Postmenopausal Bleedin

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Arko, Darja; Žegura, Branka; Virag, Mirjana; Fokter Dovnik, Nina; Takač, Iztok

2014-01-01

Primary Fallopian tube carcinoma is a rare malignancy and is not often diagnosed preoperatively. We present a case of a 67-year old woman who complained of postmenopausal vaginal bleeding. After a negative hysteroscopy, transvaginal ultrasound showed a well vascularized solid-cystic tumor in the adnexal region separate from the ovary. The presence of an adnexal mass was confirmed by MR imaging. Total abdominal hysterectomy with bilateral salpingoophorectomy, omentectomy and appendectomy, as w...

Outcomes with single agent LIPO-DOX in platinum-resistant ovarian and fallopian tube cancers and primary peritoneal adenocarcinoma - Chiang Mai University Hospital experience.

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Suprasert, Prapaporn; Manopunya, Manatsawee; Cheewakriangkrai, Chalong

2014-01-01

Single pegylated liposomal doxorubicin (PLD) is commonly used as a salvage treatment in platinum-resistant ovarian cancer, fallopian tube cancer and primary peritoneal adenocarcinoma (PPA) with a satisfactory outcome. However, the data for second generation PLD administered in this setting are still limited. We conducted a retrospective study to evaluate the outcome of patients who received single-agent second generation PLD (LIPO-DOX) after the development of clinical platinum resistance. The study period was between March 2008 and March 2013. LIPO-DOX was administered intravenously 40 mg/m2 every 28 days until disease progression, but for not more than six cycles. The response rate was evaluated using the Gynecologic Cancer Intergroup (GCIG) criteria while the toxicity was evaluated according to WHO criteria. Twenty-nine patients met the inclusion criteria in the study period with an overall response rate of 13.8%. The median progression free survival and overall survival were three and eleven months, respectively. With the total of 96 cycles of chemotherapy, the patients developed grades 3 and 4 hematologic toxicity as follows: anemia, 0%, leukopenia, 9.6%, neutropenia, 32.3% and thrombocytopenia, 0%. In conclusion, the single agent second generation PLD demonstrated modest efficacy in patients with platinum-resistant ovarian cancer, fallopian tube cancer and PPA without serious toxicity.

Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer.

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Nishida, Naoyo; Murakami, Fumihiro; Higaki, Koichi

2016-06-01

The frequency of ovarian cancers in Japan has increased; however, doubts have been raised concerning the mechanism by which high-grade serous adenocarcinomas (HGSCs) arise. Conventionally, HGSC is thought to originate from the ovarian surface epithelium or epithelial inclusion cyst. However, recent data indicate that HGSCs may in fact develop from precursor lesions in the fallopian tube, including epithelia with a p53 signature, serous tubal intraepithelial carcinomas (STICs), secretory cell outgrowths (SCOUTs), and tubal intraepithelial lesions in transition (TILT). Here, we determined the frequency of these fallopian tube precursors in surgically excised samples from 123 patients with benign pelvic diseases. We identified 12 cases with a p53 signature (9.7%), 26 with observable SCOUTs (21.1%), and 4 with TILT (3.2%), but no STIC cases. Although the lifetime risk for developing ovarian cancer is only around 1.4% for women without germ-line mutations, it is important to evaluate the presence of precursor lesions to understand HGSC pathogenesis better. Taken together, salpingectomy appears to be an option for women who are past their childbearing age and plan to undergo elective pelvic surgery. To our knowledge, this is the first study to investigate the presence of these specific precursors post-salpingectomy in low-risk patients. © 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.

Template synthesis of test tube nanoparticles using non-destructive replication.

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Wagner, Jonathan; Yao, Jingyuan; Rodgers, David; Hinds, Bruce

2013-03-01

Nano test tubes are a promising delivery vehicle for a range of therapeutics, including small molecule drugs and biologics. However, current template synthesis methods of producing nano test tubes are prohibitively expensive and time consuming. Here, non-destructive template replication was used to increase nano test tube yield from porous alumina by more than a hundredfold. We demonstrate how to produce nano test tubes of several sizes and compositions, including hybrid tubes with different inner and outer surfaces for targeted surface chemistry. Nano test tubes were readily suspended and stored in aqueous solutions without the need for chemical treatment. These nano test tubes should find application as delivery vehicles for therapeutics, particularly for processive 'bionanoreactors' loaded with enzymes.

Revised FIGO staging system for cancer of the ovary, fallopian tube, and peritoneum: important implications for radiologists.

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Saida, Tsukasa; Tanaka, Yumiko Oishi; Matsumoto, Koji; Satoh, Toyomi; Yoshikawa, Hiroyuki; Minami, Manabu

2016-02-01

Ovarian cancer is the seventh most common cancer diagnosis among women worldwide. The International Federation of Gynecology and Obstetrics recently significantly revised staging criteria for cancer of the ovary. The latest revision was based on the concept that high-grade serous tubal intraepithelial carcinoma (STIC) may be the origin of some high-grade serous carcinomas of the ovary and peritoneum. Therefore, staging criteria for the ovary, fallopian tube, and peritoneum have been unified. Understanding this background and other important revised points are essential for radiologists concerned with imaging diagnosis in gynecologic oncology. Through this review, we introduce the STIC theory and show examples of diseases in accordance with the new staging criteria based on magnetic resonance imaging (MRI) and computed tomography (CT) results.

Template synthesis of test tube nanoparticles using non-destructive replication

International Nuclear Information System (INIS)

Wagner, Jonathan; Rodgers, David; Yao Jingyuan; Hinds, Bruce

2013-01-01

Nano test tubes are a promising delivery vehicle for a range of therapeutics, including small molecule drugs and biologics. However, current template synthesis methods of producing nano test tubes are prohibitively expensive and time consuming. Here, non-destructive template replication was used to increase nano test tube yield from porous alumina by more than a hundredfold. We demonstrate how to produce nano test tubes of several sizes and compositions, including hybrid tubes with different inner and outer surfaces for targeted surface chemistry. Nano test tubes were readily suspended and stored in aqueous solutions without the need for chemical treatment. These nano test tubes should find application as delivery vehicles for therapeutics, particularly for processive ‘bionanoreactors’ loaded with enzymes. (paper)

Restaging and Survival Analysis of 4036 Ovarian Cancer Patients According to the 2013 FIGO Classification for Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

DEFF Research Database (Denmark)

Rosendahl, Mikkel; Høgdall, Claus Kim; Mosgaard, Berit Jul

2016-01-01

OBJECTIVE: With the 2013 International Federation of Gynecology and Obstetrics (FIGO) staging for ovarian, fallopian tube, and primary peritoneal cancer, the number of substages changed from 10 to 14. Any classification of a malignancy should easily assign patients to prognostic groups, refer....... MATERIALS AND METHODS: Demographic, surgical, histological, and survival data from 4036 ovarian cancer patients were used in the analysis. Five-year survival rates (5YSR) and hazard ratios for the old and revised FIGO staging were calculated using Kaplan-Meier curves and Cox regression. RESULTS: A total...

Secretory cell outgrowths, p53 signatures, and serous tubal intraepithelial carcinoma in the fallopian tubes of patients with sporadic pelvic serous carcinoma.

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Mittal, Neha; Srinivasan, Radhika; Gupta, Nalini; Rajwanshi, Arvind; Nijhawan, Raje; Gautam, Upasana; Sood, Swati; Dhaliwal, Lakhbir

2016-01-01

High-grade serous carcinomas of ovarian, tubal, and peritoneal origin are together referred as pelvic serous carcinoma. The fallopian tubes, ovarian surface epithelium, and the tuboperitoneal junctional epithelium are all implicated in pelvic serous carcinogenesis. The aim of this study is to identify putative precursor lesions of serous carcinoma including secretory cell outgrowths (SCOUTs), serous tubal intraepithelial carcinoma (STIC), and p53 signatures and assign its probable site of origin. Prospective case-control study of consecutive specimen comprising 32 serous carcinomas and 31 controls (10 normal adnexa, 10 benign and 6 atypically proliferative surface epithelial tumors, and 5 other carcinomas). Sectioning and extensive examination of the fimbrial end (SEE-FIM) protocol along with immunohistochemistry for Bcl-2, p53, and Ki-67 was employed for evaluating invasive carcinoma and precursor lesions in cases versus controls. SCOUT, p53 signatures, and STIC were most frequent in the serous carcinomas. p53 signatures and STIC were always seen in the fimbrial end. STICs were exclusively present in serous carcinomas, more common in ipsilateral tubes of cases with dominant ovarian mass. Multifocal p53 signatures with STIC were seen in 7 (21.9%) cases. STIC was present with or without an invasive carcinoma in 25% and in 6.25% of cases of pelvic serous carcinomas, respectively. The junctional epithelia did not show any lesion in any group. SEE-FIM protocol is recommended for evaluation of sporadicpelvic (ovarian/tubal/peritoneal) serous carcinoma. Based on the presence of STIC or invasive carcinoma, nearly 60% of all pelvic serous carcinomas are of fallopian tubal origin.

Non-destructive testing of tubes by electromagnetic processes

International Nuclear Information System (INIS)

Kowarski, A.

1979-01-01

This article reviews and assesses the non destructive testing techniques used for locating defects in tubes by electromagnetic processes. These form the basis of many testing devices, the diversity of which results from various factors: range of materials, methods of fabrication, specific defects of the product. There are two distinct main families of devices utilising two different principles: dispersion flow and Foucault currents [fr

[Hysteroscopic fallopian tube sterilization procedure: feasibility and one-year follow-up].

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Gibon, E; Lopès, P; Linet, T; Martigny, H; Orieux, C; Philippe, H-J

2006-03-01

Hysteroscopic flexible micro-insert (Essure) is an ambulatory improvement of fallopian tube sterilization, which is a deliberated suppression of fertility. The aim of this study was an evaluation of feasibility (learning curve) and the first year outcome of this method. This prospective study, carried out between February 2002 and March 2003, included patients who were matching with manufacturer recommendations. One surgeon only realized all the device placements. Fifty patients were included (one year follow-up). Mean age was 41 (+/-3.3), mean parity was 2.7 (+/-0.8). Mean time needed for device placement was 26 minutes (+/-6.5) and was reduced with increased experience. Six failures of placement (12%) were related, because of submucus leiomyomas, proximal tubal stenotic disease or too retroverted uterus. Only 5 patients (11,4%) described intensive pelvic pain during the placement. The only case of device expulsion benefited from a successful second placement. The one-year follow-up showed no significant difference of body weight increasing, duration or quantity of menstruation, neither significant pelvic pain nor vaginal bleeding. Tolerance was rated at least at "somewhat satisfied". There have been no pregnancies reported in 670 woman-months of effectiveness. Our results agree in any point with those of larger studies. We think that hysteroscopy micro-insert placement is not only reserved to specialized centers but also to any gynecologist who is used to performing hysteroscopy because of its feasibility.

Radiodiagnosis of extrauterine (fallopian) pregnancy

International Nuclear Information System (INIS)

Shniger, N.U.; Krivosheina, I.L.

1984-01-01

A study was made of a group of women with undisturbed fallopian pregnance and its chronic disturbance when diagnosis seems impossible to be established with clinical and laboratory methods. Water soluble high-molecular iodine contrast agents are proposed for use. Certain rules should be adhered to while conducting a study. X-ray signs of fallopian pregnancy are divided into basic and auxiliary ones. The basic signs allow one to make a conclusion of fallopian pregnancy, auxiliary ones to assume the pathology of pregnancy. Histerosalpingography in extrauterine (fallopian) pregnancy did not result in any complications, neither was it accompanied by side effects

Torsion of the fallopian the mimicking appendicitis in a pregnant woman

International Nuclear Information System (INIS)

Tapia-Vine, M.; Pedrosa, I.; Escribano, N.

2000-01-01

Isolated torsion of the fallopian tube is an uncommon entity. Given the difficulties involved in the preoperative diagnosis, the ultrasound findings characteristic of this anomaly are not widely known. We present a case of tubal torsion associated with a cyst, describing the ultrasound images in our case and those reported in the literature. (Author) 18 refs

Secretory cell outgrowths, p53 signatures, and serous tubal intraepithelial carcinoma in the fallopian tubes of patients with sporadic pelvic serous carcinoma

Directory of Open Access Journals (Sweden)

Neha Mittal

2016-01-01

Full Text Available Context: High-grade serous carcinomas of ovarian, tubal, and peritoneal origin are together referred as pelvic serous carcinoma. The fallopian tubes, ovarian surface epithelium, and the tuboperitoneal junctional epithelium are all implicated in pelvic serous carcinogenesis. Aims: The aim of this study is to identify putative precursor lesions of serous carcinoma including secretory cell outgrowths (SCOUTs, serous tubal intraepithelial carcinoma (STIC, and p53 signatures and assign its probable site of origin. Settings and Design: Prospective case-control study of consecutive specimen comprising 32 serous carcinomas and 31 controls (10 normal adnexa, 10 benign and 6 atypically proliferative surface epithelial tumors, and 5 other carcinomas. Subjects and Methods: Sectioning and extensive examination of the fimbrial end (SEE-FIM protocol along with immunohistochemistry for Bcl-2, p53, and Ki-67 was employed for evaluating invasive carcinoma and precursor lesions in cases versus controls. Results: SCOUT, p53 signatures, and STIC were most frequent in the serous carcinomas. p53 signatures and STIC were always seen in the fimbrial end. STICs were exclusively present in serous carcinomas, more common in ipsilateral tubes of cases with dominant ovarian mass. Multifocal p53 signatures with STIC were seen in 7 (21.9% cases. STIC was present with or without an invasive carcinoma in 25% and in 6.25% of cases of pelvic serous carcinomas, respectively. The junctional epithelia did not show any lesion in any group. Conclusions: SEE-FIM protocol is recommended for evaluation of sporadicpelvic (ovarian/tubal/peritoneal serous carcinoma. Based on the presence of STIC or invasive carcinoma, nearly 60% of all pelvic serous carcinomas are of fallopian tubal origin.

The wet destruction of dry organic material in a closed quartz tube

International Nuclear Information System (INIS)

Faanhof, A.; Das, H.A.

1977-01-01

Quantitative, rapid destruction of dry organic materials is necessary in many cases. The application of wet mineralization in a closed quartz tube and the optimization of destruction conditions are described. The procedure takes approximately 3.5 hours for 20 samples. The method was checked by radiotracer and activation experiments. The ratio of the Hg-203 count-rates of spiked and destructed samples to that of standards is 0.991+-0.014. The results of the instrumental analysis for tobacco and standard kale are: tobacco (84+-13) ng.g -1 , standard kale (155+-7)ng.g -1 . The average of the data for kale, reported in literature, is (150+-8)ng.g -1 . Results after destruction are: tobacco (82+-6)ng.g -1 , standard kale (158+-16)ng.g -1 . (N.L.Gy.)

Autofluorescence imaging can identify preinvasive or clinically occult lesions in fallopian tube epithelium: a promising step towards screening and early detection.

Science.gov (United States)

McAlpine, J N; El Hallani, S; Lam, S F; Kalloger, S E; Luk, M; Huntsman, D G; MacAulay, C; Gilks, C B; Miller, D M; Lane, P M

2011-03-01

Optical imaging systems are robust, portable, relatively inexpensive, and have proven utility in detecting precancerous lesions in the lung, esophagus, colon, oral cavity and cervix. We describe the use of light-induced endogenous fluorescence (autofluorescence) in identifying preinvasive and occult carcinomas in ex vivo samples of human fallopian tube (FT) epithelium. Women undergoing surgery for an i) ovarian mass, ii) a history suggestive of hereditary breast-ovarian cancer, or iii) known serous ovarian cancer following neoadjuvant chemotherapy (NAC) were approached for informed consent. Immediately following surgery, FT's were photographed in reflectance and fluorescence at high resolution. Images included: (1) white-light reflectance of luminal/epithelial surface; (2) narrow-band green reflectance (570 nm) (3) green autofluorescence (405/436 nm excitation); and (4) blue autofluorescence (405 nm excitation). Areas revealing a loss of natural tissue fluorescence or marked increase in tissue microvasculature were recorded and compared to final histopathologic diagnosis (SEE-FIM protocol). Fifty-six cases involving one or both fallopian tubes underwent reflectance and fluorescence visualization. Nine cases were excluded, either secondary to non-ovarian primary pathology (7) or excessive trauma (2) rendering tissue interpretation impossible. Of the 47 cases remaining, there were 11 high grade serous (HGS) and 9 non-serous ovarian carcinomas undergoing primary debulking surgery, 5 serous carcinomas having received NAC, 8 benign ovarian tumors, and 14 women undergoing risk-reducing bilateral salpingo-oophorectomy (RRBSO). Methodology was feasible, efficient, and reproducible. TIC or carcinoma was identified in 7/11 HGS, 3/5 NAC, and 1/14 RRBSO. Optical images were reviewed to determine test positive or negative based on standardized criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for the entire

Processing of fallopian tube, ovary, and endometrial surgical pathology specimens: A survey of U.S. laboratory practices.

Science.gov (United States)

Samimi, Goli; Trabert, Britton; Duggan, Máire A; Robinson, Jennifer L; Coa, Kisha I; Waibel, Elizabeth; Garcia, Edna; Minasian, Lori M; Sherman, Mark E

2018-03-01

Many high-grade serous carcinomas initiate in fallopian tubes as serous tubal intraepithelial carcinoma (STIC), a microscopic lesion identified with specimen processing according to the Sectioning and Extensive Examination of the Fimbria protocol (SEE-Fim). Given that the tubal origin of these cancers was recently recognized, we conducted a survey of pathology practices to assess processing protocols that are applied to gynecologic surgical pathology specimens in clinical contexts in which finding STIC might have different implications. We distributed a survey electronically to the American Society for Clinical Pathology list-serve to determine practice patterns and compared results between practice types by chi-square (χ2) tests for categorical variables. Free text comments were qualitatively reviewed. Survey responses were received from 159 laboratories (72 academic, 87 non-academic), which reported diverse specimen volumes and percentage of gynecologic samples. Overall, 74.1% of laboratories reported performing SEE-Fim for risk-reducing surgical specimens (82.5% academic versus 65.7% non-academic, p STIC or early cancer precursors. Published by Elsevier Inc.

Fast and Accurate Non-destructive Testing System for Inspection of Canning Tubes

DEFF Research Database (Denmark)

Gundtoft, Hans Erik; Nielsen, E.

1973-01-01

The authors describe the development of an inspection bench for the non-destructive examination of canning tubes. The bench is original in that the internal diameter is calculated from exact measurement of the outer diameter and the wall thickness. The transducers for inspection and control are r...

Progesterone Prevents High-Grade Serous Ovarian Cancer by Inducing Necroptosis of p53-Defective Fallopian Tube Epithelial Cells

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Na-Yiyuan Wu

2017-03-01

Full Text Available High-grade serous ovarian carcinoma (HGSOC originates mainly from the fallopian tube (FT epithelium and always carries early TP53 mutations. We previously reported that tumors initiate in the FT fimbria epithelium because of apoptotic failure and the expansion of cells with DNA double-strand breaks (DSB caused by bathing of the FT epithelial cells in reactive oxygen species (ROSs and hemoglobin-rich follicular fluid (FF after ovulation. Because ovulation is frequent and HGSOC is rare, we hypothesized that luteal-phase progesterone (P4 could eliminate p53-defective FT cells. Here we show that P4, via P4 receptors (PRs, induces necroptosis in Trp53−/− mouse oviduct epithelium and in immortalized human p53-defective fimbrial epithelium through the TNF-α/RIPK1/RIPK3/MLKL pathway. Necroptosis occurs specifically at diestrus, recovers at the proestrus phase of the estrus cycle, and can be augmented with P4 supplementation. These results reveal the mechanism of the well-known ability of progesterone to prevent ovarian cancer.

Improvement in reliability and accuracy of heater tube eddy current testing by integration with an appropriate destructive test

International Nuclear Information System (INIS)

Giovanelli, F.; Gabiccini, S.; Tarli, R.; Motta, P.

1988-01-01

A specially developed destructive test is described showing how the reliability and accuracy of a non-destructive technique can be improved if it is suitably accompanied by an appropriate destructive test. The experiment was carried out on samples of AISI 304L tubes from the low-pressure (LP) preheaters of a BWR 900 MW nuclear plant. (author)

Analysis of fallopian tube recanalization in 37 cases with Foley catheter infusion under pressure through DSA

International Nuclear Information System (INIS)

Huang Qiuli; Song Kankan; Wu Anle; Shu Jing

2000-01-01

Objective: To investigate the safe, effective, simple and direct method in the re-canalization of fallopian tubal obstruction. Methods: Fallopian tubal obstructive infertility in 37 cases were re-canalized with Foley catheter under pressure infusion through DSA, including primary infertility in 17 cases and secondary infertility in 20 cases. The average infertility term was 4 years. Results: In the 37 cases, 18 cases were treated once, twice in 16 cases, and thrice in 3 cases. The oviduct recanalization rate was 95% (35/37) with one failure and another unsatisfactory. After several times of recanalization in 19 cases, the pelvic cavity adhesion were reduced in 15 cases (79%), no change in 3 cases (16%), and aggravated in one case (5%). Conclusions: This method is simple, cheap, safety, effective and low in X-ray exposure. The authors insist on the pelvic cavity adhesion is still the chief cause of infertility after recanalization and still need other kind of treatment

Epothilones in epithelial ovarian, fallopian tube, or primary peritoneal cancer: a systematic review

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Zagouri F

2015-08-01

Full Text Available Flora Zagouri,1 Theodoros N Sergentanis,2 Dimosthenis Chrysikos,2 Meletios-Athanassios Dimopoulos,1 Aristotle Bamias1 1Department of Clinical Therapeutics, Alexandra Hospital, 2First Propaedeutic Surgical Department, Hippokration Hospital, University of Athens, Athens, Greece Abstract: Ovarian cancer is the most lethal gynecologic malignancy; consequently, there is a need for effective therapies. Epothilones are microtubule-stabilizing agents that inhibit cell growth. Currently, patupilone and its four synthetic derivatives ixabepilone, BMS-310705, sagopilone, 20-desmethyl-20-methylsulfanyl epothilone B and epothilone D, as well as its derivative KOS-1584, are under clinical evaluation. This is the first systematic review conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines that synthesizes all available data emerging from trials and evaluates the efficacy and safety of epothilones in epithelial ovarian, primary fallopian tube, and primary peritoneal cancer. Despite the fact that epothilones have proven active in taxane-resistant settings in preclinical models, it is not yet clear from Phase II/III studies reviewed here that their clinical activity is superior to that of taxanes. Nevertheless, responses to epothilones have been observed in platinum-refractory/resistant ovarian cancer patients. Moreover, despite the shared mechanism of action of epothilones, their clinical profile seems clearly different, with diarrhea being the most common dose-limiting toxicity encountered with patupilone, whereas neutropenia and sensory neuropathy are the most common toxic effects observed with the other epothilones. In any case, randomized trials comparing epothilones with standard treatments seem warranted to define further the role of these agents, whereas biomarker analysis might further optimize patient selection. Keywords: ovarian cancer, epothilone, patupilone, ixabepilone, systematic

Limits to the Recognizability of Flaws in Non-Destructive Testing Steam-Generator Tubes for Nuclear-Power Plants

International Nuclear Information System (INIS)

Kuhlmann, A.; Adamsky, F.-J.

1965-01-01

In the Federal Republic of Germany there are nuclear reactors under construction with steam generators inside the reactor pressure-vessel. As a result design repairs of steam- generator tubes are very difficult and cause large shut-down times of the nuclear-power plant. It is known that numerous troubles in operating conventional power plants are results of steam-generator tube damages. Because of the high total costs of these reactors it. is necessary to construct the steam generators especially in such a manner that the load factor of the power plant is as high as possible. The Technischer Überwachungs-Verein Rheinland was charged to supervise and to test fabrication and construction of the steam generators to see that this part of the plant was as free of defects as possible. The experience gained during this work is of interest for manufacture and construction of steam generators for nuclear-power plants in general. This paper deals with the efficiency limits of non-destructive testing steam-generator tubes. The following tests performed will be discussed in detail: (a) Automatic ultrasonic testing of the straight tubes in the production facility; (b) Combined ultrasonic and radiographic testing of the bent tubes and tube weldings; (c) Other non-destructive tests. (author) [fr

Integrated straight - through automatic non-destructive examination and data acquisition system for thin-wall tubes

International Nuclear Information System (INIS)

Stoessel, A.; Boulanger, G.; Furlan, J.; Mogavero, R.

1981-09-01

This non-destructive testing unit inspects the cladding tubes for the SUPER-PHENIX fast neutron reactor. The quality level demanded for these tubes, as well as their number, required designing an installation that combined high performance with a great testing rate and complete automation. The testing is effected under immersion by means of six transducers, focused in line, working at 30 MHz. The tubes are numbered on an automatic rig; marking is by dark rings obtained by superficial electrolysis of the tube and regularly distributed on the abscissa; the quality of the tube is not affected by this. The advantage of this numbering system is that it enables the tubes to be fed to the test set in any order. An acquisition unit, constituted of a microprocessor, a semi-graphical printer and a double floppy disk unit, makes it possible to enter, edit and store the information for each tube [fr

Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer

DEFF Research Database (Denmark)

Sabbatini, Paul J; Ragupathi, Govind; Hood, Chandra

2007-01-01

PURPOSE: To characterize the safety and immunogenicity of a heptavalent antigen-keyhole limpet hemocyanin (KLH) plus QS21 vaccine construct in patients with epithelial ovarian, fallopian tube, or peritoneal cancer in second or greater complete clinical remission. EXPERIMENTAL DESIGN: Eleven......). RESULTS: Eleven patients were included in the safety analysis; 9 of 11 patients remained on study for at least 2 weeks past fourth vaccination and were included in the immunologic analysis (two withdrew, disease progression). The vaccine was well tolerated. Self-limited and mild fatigue (maximum grade 2...... patients in this pilot trial received a heptavalent vaccine s.c. containing GM2 (10 microg), Globo-H (10 microg), Lewis Y (10 microg), Tn(c) (3 microg), STn(c) (3 microg), TF(c) (3 microg), and Tn-MUC1 (3 microg) individually conjugated to KLH and mixed with adjuvant QS21(100 microg). Vaccinations were...

Transuterinal artery interventional therapy for fallopian tubal pregnancy

International Nuclear Information System (INIS)

Jiang Zaibo; Shan Hong; Guan Shouhai; Ma Zhuang; Huang Mingsheng; Li Zhengran; Zhu Kangshun; Chen Hanwei; Xiao Jibo; Mu Yongsheng

2001-01-01

Objective: To study the methods and clinical effect of transuterinal artery interventional therapy of fallopian tubal pregnancy. Methods: The authors cured 34 cases of fallopian tubal pregnancy by interventional methods. In the procedure, 4.1 - 5.0 F catheters were used for performing super selective angiography in uterine artery and then infusing Methotrexate 50-100 mg. Finally gelfoam particles or stripes were used to embolise uterine artery. Before and after the procedure, patients showed changes of clinical symptom, physical signs. Value of urine β-hCG and size of pregnancy cyst were studied. Results: 31 cases were succeeded. The successful rate was 91%. 37 fallopian tubal arteries were displayed in 40 uterine arterial angiographies. The stain of ovary was shown done in 21 cases, the appearance rate was 68%. The stain of pregnant cyst was in six cases, the appearance rate was 18%. Conclusion: It is safe and efficient in performing transuterine artery chemo-embolization for therapy of fallopian tubal pregnancy. It could prevent and control fatal bleeding induced by pregnancy cyst rupture

Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies

Directory of Open Access Journals (Sweden)

Karin Hellner

2016-08-01

Full Text Available Current screening methods for ovarian cancer can only detect advanced disease. Earlier detection has proved difficult because the molecular precursors involved in the natural history of the disease are unknown. To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points over three years from a single patient during treatment for high-grade serous ovarian cancer (HGSOC. The functional and clinical significance of the identified mutations was examined using a combination of population-based whole genome sequencing, targeted deep sequencing, multi-center analysis of protein expression, loss of function experiments in an in-vivo reporter assay and mammalian models, and gain of function experiments in primary cultured fallopian tube epithelial (FTE cells. We identified frequent mutations involving a 40 kb distal repressor region for the key stem cell differentiation gene SOX2. In the apparently normal FTE, the region was also mutated. This was associated with a profound increase in SOX2 expression (p < 2−16, which was not found in patients without cancer (n = 108. Importantly, we show that SOX2 overexpression in FTE is nearly ubiquitous in patients with HGSOCs (n = 100, and common in BRCA1-BRCA2 mutation carriers (n = 71 who underwent prophylactic salpingo-oophorectomy. We propose that the finding of SOX2 overexpression in FTE could be exploited to develop biomarkers for detecting disease at a premalignant stage, which would reduce mortality from this devastating disease.

Torsion of the fallopian the mimicking appendicitis in a pregnant woman; Torsion de la trompa de Falopio en una mujer gestante simulando apendicitis

Energy Technology Data Exchange (ETDEWEB)

Tapia-Vine, M.; Pedrosa, I.; Escribano, N. [Hospital Clinico San Carlos (Spain)

2000-07-01

Isolated torsion of the fallopian tube is an uncommon entity. Given the difficulties involved in the preoperative diagnosis, the ultrasound findings characteristic of this anomaly are not widely known. We present a case of tubal torsion associated with a cyst, describing the ultrasound images in our case and those reported in the literature. (Author) 18 refs.

Cancer of the ovary, fallopian tube, and peritoneum: a population-based comparison of the prognostic factors and outcomes.

Science.gov (United States)

Rottmann, Miriam; Burges, A; Mahner, S; Anthuber, C; Beck, T; Grab, D; Schnelzer, A; Kiechle, M; Mayr, D; Pölcher, M; Schubert-Fritschle, G; Engel, J

2017-09-01

The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of the Munich Cancer Registry (meanwhile 4.8 million inhabitants). Tumour site differences were examined by comparing prognostic factors, treatments, the time to progression, and survival. The effect of the tumour site was additionally analysed by a Cox regression model. The median age at diagnosis, histology, and FIGO stage significantly differed among the tumour sites (p < 0.001); PC patients were older, more often diagnosed with a serous subtype, and in FIGO stage III or IV. The time to progression and survival significantly differed among the tumour sites. When stratified by FIGO stage, the differences in time to progression disappeared, and the differences in survival considerably weakened. The differences in the multivariate survival analysis showed an almost identical outcome in PC patients (HR 1.07 [0.91-1.25]) and an improved survival of FC patients (HR 0.63 [0.49-0.81]) compared to that of OC patients. The comparison of OC, FC, and PC patients in this large-scale population-based study showed differences in the prognostic factors. These differences primarily account for the inferior outcome of PC patients, and for the improved survival of FC compared to OC patients.

Hysterosalpingographic Appearances of Female Genital Tract Tuberculosis: Part I. Fallopian Tube

Directory of Open Access Journals (Sweden)

Firoozeh Ahmadi

2014-01-01

Full Text Available Female genital tuberculosis (TB remains as a major cause of tubal obstruction leading to infertility, especially in developing countries. The global prevalence of genital tuberculosis has increased during the past two decades due to increasing acquired immunodeficiency syndrome (AIDS. Genital TB is commonly asymptomatic, and it is diagnosed during infertility investigations. Despite of recent advances in imaging tools, such as computerized tomography (CT scan, magnetic resonance imaging (MRI and ultrasongraphy, hysterosalpingography is still the standard screening test for evaluation of tubal infertility and a valuable tool for diagnosis of female genital tuberculosis. Tuberculosis gives rise to various appearances on hysterosalpingography (HSG from non-specific changes to specific findings. The present pictorial review illustrates and describes specific and non-specific radiographic features of female genital tuberculosis in two parts. Part I presents specific findings of tuberculosis related to tubes such as "beaded tube", "golf club tube", "pipestem tube", "cobble stone tube" and "leopard skin tube". Part II describes adverse effects of tuberculosis on structure of endometrium and radiological specific findings such as "dwarfed" uterus with lymphatic intravasation and occluded tubes, "T-shaped" tuberculosis uterus, "pseudounicornuate" uterus and "Collar-stud abscess", which have not been encountered in the majority of non-tuberculosis cases.

Granisetron, Aprepitant, and Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Stage II, III, or IV Ovarian Cancer

Science.gov (United States)

2018-04-24

Nausea and Vomiting; Ovarian Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Cystadenocarcinoma; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIA Ovarian Cancer; Stage IIB Fallopian Tube Cancer; Stage IIB Ovarian Cancer; Stage IIC Fallopian Tube Cancer; Stage IIC Ovarian Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Cancer; Stage IIIA Primary Peritoneal Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Cancer; Stage IIIB Primary Peritoneal Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Cancer; Stage IIIC Primary Peritoneal Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer; Undifferentiated Ovarian Carcinoma

[Clinical Value of Prophylactic Salpingectomy in Hysterectomy due to Uterine Benign Lesions].

Science.gov (United States)

Zhao, Ling-Jun; Wang, Ping; Li, Xiu-Ying

2017-03-01

To explore the clinical value of resection of bilateral fallopian tubes in patients with benign uterine diseases who received (laparoscopic) hysterectomy or subhysterectomy through the postoperative pathologic analysis of resected fallopian tubes. A retrospective analysis was conducted to review the histopathological examination results in 1 272 women who underwent (laparoscopic) total hysterectomy or subtotal hysterectomy and the removal of bilateral fallopian tube simultaneously due to uterine leiomyoma, adenomyosis and other benign lesions from December 2010 to December 2015. Of the 1 272 patients, laparoscopic resection was underwent in 1 005 patients (79.01%) and laparotomy in 267 patients (20.99%). In the attachment area, 334 patients (26.26%) had tenderness signs, and 401 patients (31.53%) had signs of thickening. Total 2 498 fallopian tubes were removed. There were 1 654 tubal with no obvious abnormal appearance (66.21%), 636 tubal with lumen part of the uplift (25.46%), 128 fallopian tube with congestion and swelling (5.12%), 80 fallopian tube atrophy adhesions (3.20%). Pathological. showed 2 386 (95.52%) fallopian tubes with chronic fallopian tube inflammation, 988 (39.55%) of fallopian tube cyst, 80 (3.20%) of normal fallopian tube, 78 (3.12%) of tubal effusion, 48 (1.92% ) of tubal hyperplasia, 4 (0.26%) of tubal benign tumor, 8 (0.32%) of tubal mucosa atypical hyperplasia change and 2(0.08%) of tubal cancer. In the 10 cases of fallopian tube cancer and atypical hyperplasia, 8 had obvious changes of chronic inflammation in the contralateral fallopian tube, including 7 cases of atypical hyperplasia and 1 case of fallopian tube cancer. Prophylactic salpingectomy can prevent the occurrence of tubal inflammation and removal cancer incentives.

A multicenter, non-randomized, phase II study of docetaxel and carboplatin administered every 3 weeks as second line chemotherapy in patients with first relapse of platinum sensitive epithelial ovarian, peritoneal or fallopian tube cancer

DEFF Research Database (Denmark)

Wang, Yun; Herrstedt, Jørn; Havsteen, Hanne

2014-01-01

of 398 cycles were given. Grade 3/4 neutropenia was seen in 80% (59 of 74) patients with an incidence of febrile neutropenia of 16%. Grade 2/3 sensory peripheral neuropathy occurred in 7% of patients, but no grade 4 sensory peripheral neuropathy was observed. Sixty patients were evaluable for response...... of platinum-sensitive ovarian, peritoneal and Fallopian tube cancer. The major toxicity was neutropenia, while the frequency of peripheral neuropathy was low.......BACKGROUND: In patients with ovarian cancer relapsing at least 6 months after end of primary treatment, the addition of paclitaxel to platinum treatment has been shown to improve survival but at the cost of significant neuropathy. In the first line setting, the carboplatin-docetaxel combination...

Atypisk symptomdebut af cancer i tuba ovarii

DEFF Research Database (Denmark)

Hviid, Malene Meisner; Teklay, Biniam; Jensen, Pernille Tine

2013-01-01

with metastases to both ovaries and one inguinal lymph node. Recent studies suggest that serous borderline tumour of the ovaries originate from the fallopian tubes. The present case confirms this hypothesis. PET-CT is an important tool in diagnosing ovarian and fallopian tube cancers.......Fallopian tube cancer is rare and accounts for 0.3-1% of all gynaecological cancers. We describe a case of undiagnosed fallopian tube cancer presenting as a swollen inguinal lymph node and later diagnosed with PET-CT. Final histology revealed a serous adenocarcinoma of the fallopian tube...

Non-destructive testing of high pressure fibre reinforced composites tubes by computed tomography

Energy Technology Data Exchange (ETDEWEB)

Klimek, L. [Qualitaetszentrum Dortmund (Germany); Monstadt, H.; Boedecker, T. [EFMT, Bochum (Germany)

1995-12-31

For new applications of fibre reinforced composites, new non-destructive testing methods are required which on the one hand can be used as a quality testing method and on the other hand as an in-service inspection method during the life of a product. Special attention should be paid to the defect sensitivity and to a detailed classification of visible defects. Defining a detectable standard, comparable investigations were carried out using the Ultra Fast Scanner which is located at the Entwicklungs- und Forschungszentrum fuer Mikrotherapie gGmbH (EFMT) and the industrial scanner of the Qualitaetszentrum Dortmund GmbH u. Co. KG (QZ-DO). The investigation object is a high pressure tube which is made up of three different diameter structures. There can be distinguished between three types of tube layers. Digital image processing has been used to get more information form measured data. We developed two different types of digital image filters: A SIGMA and a Contrast Sensitive Weights (CSW) image filter and made a comparative study. (orig./RHM)

[Expansion of secretory cells in the fallopian tubal epithelium in the early stages of the pathogenesis of ovarian serous carcinomas].

Science.gov (United States)

Asaturova, A V; Ezhova, L S; Faizullina, N M; Adamyan, L V; Khabas, G N; Sannikova, M V

to investigate the frequency of the types of fallopian tubal secretory cell expansion (SCE) in diseases of the reproductive organs and to determine the immunophenotype and biological role of the cells in the early stages of the pathogenesis of high-grade ovarian serous carcinomas (HGOSC). The investigation enrolled 287 patients with extraovarian diseases and ovarian serous tumors varying in grade, whose fallopian tubes were morphologically and immunohistochemically examined using p53, Ki-67, PAX2, Bcl-2, beta-catenin, and ALDH1 markers. The material was statistically processed applying the Mann-Whitney test and χ2 test. The rate of secretory cell proliferation (SCP) (more than 10 consecutive secretory cells) and that of secretory cell overgrowth (SCO) (more than 30 consecutive secretory cells) increase with age in all investigated reproductive system diseases. The rate of SCP in the corpus fimbriatum of the patients with HGOSC was 5.9 times higher than that in those with extraovarian disease (pepithelium (2.8), in SCP (1.3), in SCO (1.2), in serous tubal intraepithelial carcinoma (STIC) (1.0), and in HGOSC (0.9); Bcl-2 was in the intact epithelium (2.2), in SCP (2.1), STIC (0.9), and in HGOSC (0.6), β-catenin was in the intact epithelium (0.5), in SCP (2.85), in SCO (2.95), in STIC (0.6), and in HGOSC (0.5); ALDH1 was in the intact epithelium (0.5), in SCP (2.91), in SCO (2.92), in STIC (1.2), and in HGOSC (0.6). There were statistically significant differences with a 95% confidence interval (pepithelium and pathology (fallopian tube lesions and HGOSC); 2) Bcl-2 between the intact epithelium and SCE (SCP and SCO) and between SCE and HGOSC; 3) beta-catenin between the intact epithelium and SCE (SCP and SCO) and between SCE and HGOSC; 4) ALDH1 between the intact epithelium and SCE, between and SCE and STIC, and between STIC and HGOSC. SCE was shown to be an independent intraepithelial lesion. The incidence of this abnormality increased with age and significantly

PWR steam generator tubing sample library

International Nuclear Information System (INIS)

Anon.

1987-01-01

In order to compile the tubing sample library, two approaches were employed: (a) tubing sample replication by either chemical or mechanical means, based on field tube data and metallography reports for tubes already destructively examined; and (b) acquisition of field tubes removed from operating or retired steam generators. In addition, a unique mercury modeling concept is in use to guide the selection of replica samples. A compendium was compiled that summarizes field observations and morphologies of steam generator tube degradation types based on available NDE, destructive examinations, and field reports. This compendium was used in selecting candidate degradation types that were manufactured for inclusion in the tube library

Incidental Serous Tubal Intraepithelial Carcinoma and Non-Neoplastic Conditions of the Fallopian Tubes in Grossly Normal Adnexa: A Clinicopathologic Study of 388 Completely Embedded Cases.

Science.gov (United States)

Seidman, Jeffrey D; Krishnan, Jayashree; Yemelyanova, Anna; Vang, Russell

2016-09-01

Serous tubal intraepithelial carcinoma (STIC), the putative precursor of the majority of extrauterine high-grade serous carcinomas, has been reported in both high-risk women (those with a germline BRCA mutation, a personal history of breast carcinoma, and/or family history of breast or ovarian carcinoma) and average risk women from the general population. We reviewed grossly normal adnexal specimens from 388 consecutive, unselected women undergoing surgery, including those with germline BRCA mutation (37 patients), personal history of breast cancer or family history of breast/ovarian cancer (74 patients), endometrial cancer (175 patients), and a variety of other conditions (102 patients). Among 111 high-risk cases and 277 non-high-risk cases, 3 STICs were identified (0.8%), all in non-high-risk women (high risk vs. non-high risk: P=not significant). STIC was found in 2 women with nonserous endometrial carcinoma and 1 with complex atypical endometrial hyperplasia. Salpingoliths (mucosal calcifications), found in 9% of high-risk cases, and fimbrial adenofibromas in 9.9% of high-risk cases, were significantly more common in high-risk as compared with non-high-risk women (1.8% and 2.5%, respectively; PSTIC and endometrial hyperplasia and carcinoma, and clarify the frequency of non-neoplastic tubal findings in grossly normal fallopian tubes.

Infection of Human Fallopian Tube Epithelial Cells with Neisseria gonorrhoeae Protects Cells from Tumor Necrosis Factor Alpha-Induced Apoptosis

Science.gov (United States)

Morales, Priscilla; Reyes, Paz; Vargas, Macarena; Rios, Miguel; Imarai, Mónica; Cardenas, Hugo; Croxatto, Horacio; Orihuela, Pedro; Vargas, Renato; Fuhrer, Juan; Heckels, John E.; Christodoulides, Myron; Velasquez, Luis

2006-01-01

Following infection with Neisseria gonorrhoeae, bacteria may ascend into the Fallopian tubes (FT) and induce salpingitis, a major cause of infertility. In the FT, interactions between mucosal epithelial cells and gonococci are pivotal events in the pathogen's infection cycle and the inflammatory response. In the current study, primary FT epithelial cells were infected in vitro with different multiplicities of infection (MOI) of Pil+ Opa+ gonococci. Bacteria showed a dose-dependent association with cells and induced the secretion of tumor necrosis factor alpha (TNF-α). A significant finding was that gonococcal infection (MOI = 1) induced apoptosis in approximately 30% of cells, whereas increasing numbers of bacteria (MOI = 10 to 100) did not induce apoptosis. Apoptosis was observed in only 11% of cells with associated bacteria, whereas >84% of cells with no adherent bacteria were apoptotic. TNF-α was a key contributor to apoptosis, since (i) culture supernatants from cells infected with gonococci (MOI = 1) induced apoptosis in naïve cultures, suggesting that a soluble factor was responsible; (ii) gonococcal infection-induced apoptosis was inhibited with anti-TNF-α antibodies; and (iii) the addition of exogenous TNF-α induced apoptosis, which was inhibited by the presence of increasing numbers of bacteria (MOI = 10 to 100). These data suggest that TNF-α-mediated apoptosis of FT epithelial cells is likely a primary host defense mechanism to prevent pathogen colonization. However, epithelial cell-associated gonococci have evolved a mechanism to protect the cells from undergoing TNF-α-mediated apoptosis, and this modulation of the host innate response may contribute to establishment of infection. Understanding the antiapoptotic mechanisms used by Neisseria gonorrhoeae will inform the pathogenesis of salpingitis and could suggest new intervention strategies for prevention and treatment of the disease. PMID:16714596

Status report on the destructive and non-destructive examinations of U-bends removed from Trojan steam generator D

International Nuclear Information System (INIS)

Aspden, R.G.

1981-01-01

The last status report on the non-destructive examination of U-bends removed from Trojan steam generator D was dated July 7, 1980. As part of this activity, the measurement of wall thicknesses on selected U-bends was planned using an ultrasonic gage. These readings were not made because reproducible results could not be obtained using water as the coupling fluid which was necessary to avoid contamination. Three tubes from the same heat were selected for destructive examination at Westinghouse: one leaking U-bend (R1-C6) and two tubes with no indications (R1-C10 and R1-C22). Results of the examination procedure are presented. The non-destructive examination results from the July 7, 1980 report for 29 U-bends are included

STUDIES ON HUMAN FALLOPIAN TUBAL EPITHELIUM IN DIFFERENT AGE GROUPS

Directory of Open Access Journals (Sweden)

Jayasri

2016-02-01

Full Text Available BACKGROUND AND AIMS The “fallopian tubes” (oviducts or uterine tubes are long paired flexuous reproductive organ which transports ova, spermatozoa, zygotes, the pre-implantation morulae and blastocyst. It has major role during reproductive period, but it remains as if vestigial organ before puberty and after menopause. Due to increasing rate of tubal block and infertility, oviducts and their structures gaining importance and have become a subject of research in present days particularly epithelium. The aim of the study is to ascertain any histological difference of tubal epithelium in different age groups and the research work could be utilized for investigation and management of infertility. MATERIALS AND METHODS Seven samples of each group i.e., prereproductive, reproductive & postmenopausal were collected from fresh unembalmed human cadavers received in the department of Anatomy, FAA Medical College, Barpeta, Assam. The slides were prepared using the standard laboratory procedure. Under low and high power objectives the type of cells were observed and epithelial height was measured in the different segments. Stress was given for any significant difference of epithelial height between the different age groups. RESULTS Study revealed that among the groups within the same segment, epithelial height was recorded highest (33.57µm in reproductive group as against the lowest (22.91µm in post-menopausal group. Epithelial structures of the prereproductive and reproductive groups were significantly differed (p<0.01 from the postmenopausal group. CONCLUSIONS From the findings of the present study it can be concluded that: 1. In all the groups fallopian tubal epithelium is of simple columnar type and contains three types of cells. Cells are ciliated, secretory & peg (intercalary cells. 2. In all the groups same type of increasing trend of epithelial height from intramural segment to ampullary segment was recorded. 3. In intergroup comparison of

N Reactor pressure tube 2566 postirradiation examination

International Nuclear Information System (INIS)

Scott, K.V.

1978-01-01

Pressure tube 2566 was removed from N Reactor in July, 1977 to initiate the postirradiation examination program required by the Technical Specifications. Destructive examination of the pressure tube, after a maximum accumulated fluence of 4.6 x 10 21 n/cm 2 (E > 1 MeV), was conducted at the Hanford Engineering Development Laboratory to determine the effects of reactor service on the mechanical properties and hydrogen absorption and corrosion characteristics of the pressure tube. Tube 2566 is the sixth tube removed for destructive examination since the initial reactor startup. Evaluation of test results reveal that no significant detrimental changes have occurred in the parameters studied, since the last tube was removed in 1974

Failure analysis of retired steam generator tubings

Energy Technology Data Exchange (ETDEWEB)

Kim, Hong Pyo; Kim, J. S.; Hwang, S. S. and others

2005-04-15

Degradation of steam generator leads to forced outage and extension of outage, which causes increase in repair cost, cost of purchasing replacement power and radiation exposure of workers. Steam generator tube rupture incident occurred in Uljin 4 in 2002, which made public sensitive to nuclear power plant. To keep nuclear energy as a main energy source, integrity of steam generator should be demonstrated. Quantitative relationship between ECT(eddy current test) signal and crack size is needed in assesment of integrity of steam generator in pressurized water reactor. However, it is not fully established for application in industry. Retired steam generator of Kori 1 has many kinds of crack such as circumferential and axial primary water stress corrosion crack and outer diameter stress corrosion crack(ODSCC). So, it can be used in qualifying and improving ECT technology and in condition monitoring assesment for crack detected in ISI(in service inspection). In addition, examination of pulled tube of Kori 1 retired steam generator will give information about effectiveness of non welded sleeving technology which was employed to repair defect tubes and remedial action which was applied to mitigate ODSCC. In this project, hardware such as semi hot lab. for pulled tube examination and modification transportation cask for pulled tube and software such as procedure of transportation of radioactive steam generator tube and non-destructive and destructive examination of pulled tube were established. Non-destructive and destructive examination of pulled tubes from Kori 1 retired steam generator were performed in semi hot lab. Remedial actions applied to Kori 1 retired steam generator, PWSCC trend and bulk water chemistry and crevice chemistry in Kori 1 were evaluated. Electrochemical decontamination technology for pulled tube was developed to reduce radiation exposure and enhance effectiveness of pulled tube examination. Multiparameter algorithm developed at ANL, USA was

Cediranib, an oral inhibitor of vascular endothelial growth factor receptor kinases, is an active drug in recurrent epithelial ovarian, fallopian tube, and peritoneal cancer.

Science.gov (United States)

Matulonis, Ursula A; Berlin, Suzanne; Ivy, Percy; Tyburski, Karin; Krasner, Carolyn; Zarwan, Corrine; Berkenblit, Anna; Campos, Susana; Horowitz, Neil; Cannistra, Stephen A; Lee, Hang; Lee, Julie; Roche, Maria; Hill, Margaret; Whalen, Christin; Sullivan, Laura; Tran, Chau; Humphreys, Benjamin D; Penson, Richard T

2009-11-20

Angiogenesis is important for epithelial ovarian cancer (EOC) growth, and blocking angiogenesis can lead to EOC regression. Cediranib is an oral tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptor (VEGFR) -1, VEGFR-2, VEGFR-3, and c-kit. We conducted a phase II study of cediranib for recurrent EOC or peritoneal or fallopian tube cancer; cediranib was administered as a daily oral dose, and the original dose was 45 mg daily. Because of toxicities observed in the first 11 patients, the dose was lowered to 30 mg. Eligibility included 16 weeks, or CA-125 nonprogression > 16 weeks), which was the primary end point, was 30%; eight patients (17%; 95% CI, 7.6% to 30.8%) had a PR, six patients (13%; 95% CI, 4.8% to 25.7%) had SD, and there were no CRs. Eleven patients (23%) were removed from study because of toxicities before two cycles. Grade 3 toxicities (> 20% of patients) included hypertension (46%), fatigue (24%), and diarrhea (13%). Grade 2 hypothyroidism occurred in 43% of patients. Grade 4 toxicities included CNS hemorrhage (n = 1), hypertriglyceridemia/hypercholesterolemia/elevated lipase (n = 1), and dehydration/elevated creatinine (n = 1). No bowel perforations or fistulas occurred. Median PFS was 5.2 months, and median OS has not been reached; median follow-up time is 10.7 months. Cediranib has activity in recurrent EOC, tubal cancer, and peritoneal cancer with predictable toxicities observed with other TKIs.

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Science.gov (United States)

McCluggage, W Glenn; Judge, Meagan J; Clarke, Blaise A; Davidson, Ben; Gilks, C Blake; Hollema, Harry; Ledermann, Jonathan A; Matias-Guiu, Xavier; Mikami, Yoshiki; Stewart, Colin J R; Vang, Russell; Hirschowitz, Lynn

2015-08-01

A comprehensive pathological report is essential for optimal patient management, cancer staging and prognostication. In many countries, proforma reports are used but these vary in their content. The International Collaboration on Cancer Reporting (ICCR) is an alliance formed by the Royal College of Pathologists of Australasia, the Royal College of Pathologists of the United Kingdom, the College of American Pathologists, the Canadian Partnership Against Cancer and the European Society of Pathology, with the aim of developing an evidence-based reporting data set for each cancer site. This will reduce the global burden of cancer data set development and reduplication of effort by different international institutions that commission, publish and maintain standardised cancer reporting data sets. The resultant standardisation of cancer reporting will benefit not only those countries directly involved in the collaboration but also others not in a position to develop their own data sets. We describe the development of a cancer data set by the ICCR expert panel for the reporting of primary ovarian, fallopian tube and peritoneal carcinoma and present the 'required' and 'recommended' elements to be included in the report with an explanatory commentary. This data set encompasses the recent International Federation of Obstetricians and Gynaecologists staging system for these neoplasms and the updated World Health Organisation Classification of Tumours of the Female Reproductive Organs. The data set also addresses issues about site assignment of the primary tumour in high-grade serous carcinomas and proposes a scoring system for the assessment of tumour response to neoadjuvant chemotherapy. The widespread implementation of this data set will facilitate consistent and accurate data collection, comparison of epidemiological and pathological parameters between different populations, facilitate research and hopefully will result in improved patient management.

Hybrid friction diffusion bonding of 316L stainless steel tube-to-tube sheet joints for coil-wound heat exchangers

Energy Technology Data Exchange (ETDEWEB)

Haneklaus, Nils; Cionea, Cristian; Reuven, Rony; Frazer, David; Hosemann, Peter; Peterson, Per F. [Dept of Nuclear Engineering, University of California, Berkeley (United States)

2016-11-15

Hybrid friction diffusion bonding (HFDB) is a solid-state bonding process first introduced by Helmholtz-Zentrum Geesthacht to join aluminum tube-to-tube sheet joints of Coil-wound heat exchangers (CWHE). This study describes how HFDB was successfully used to manufacture 316L test samples simulating tube-to-tube sheet joints of stainless steel CWHE for molten salt coolants as foreseen in several advanced nuclear- and thermal solar power plants. Engineering parameters of the test sample fabrication are presented and results from subsequent non-destructive vacuum decay leak testing and destructive tensile pull-out testing are discussed. The bonded areas of successfully fabricated samples as characterized by tube rupture during pull-out tensile testing, were further investigated using optical microscopy and scanning electron microscopy including electron backscatter diffraction.

Comparative transcriptome analysis links distinct peritoneal tumor spread types, miliary and non-miliary, with putative origin, tubes and ovaries, in high grade serous ovarian cancer.

Science.gov (United States)

Auer, Katharina; Bachmayr-Heyda, Anna; Aust, Stefanie; Grunt, Thomas W; Pils, Dietmar

2017-03-01

High grade serous ovarian cancer (HGSOC) is characterized by extensive local, i.e. peritoneal, tumor spread, manifested in two different clinical presentations, miliary (many millet sized peritoneal implants) and non-miliary (few large exophytically growing peritoneal nodes), and an overall unfavorable outcome. HGSOC is thought to arise from fallopian tube secretory epithelial cells, via so called serous tubal intraepithelial carcinomas (STICs) but an ovarian origin was never ruled out for at least some cases. Comparative transcriptome analyses of isolated tumor cells from fresh HGSOC tissues and (immortalized) ovarian surface epithelial and fallopian tube secretory epithelial cell lines revealed a close relation between putative origin and tumor spread characteristic, i.e. miliary from tubes and non-miliary from ovaries. The latter were characterized by more mesenchymal cell characteristics, more adaptive tumor immune infiltration, and a favorable overall survival. Several molecular sub-classification systems (Crijns' overall survival signature, Yoshihara's subclasses, and a collagen-remodeling signature) seem to already indicate origin. Putative origin alone is a significant independent predictor for HGSOC outcome, validated in independent patient cohorts. Characteristics of both spread types could guide development of new targeted therapeutics, which are urgently needed. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The diagnostic value of radionuclide hysterosalphingography on oviduct function in infertile women

International Nuclear Information System (INIS)

Liu Zhixiang; Li Guangyu; Li Zhigang; Dong Jian; Ren Chun'e; Li Yanmin; Jiang Aifang

2006-01-01

Objective: To study the criteria of normal and abnormal oviduct function and the difference of oviduct function between the primary and secondary infertile patients. Methods: Twenty-nine cases of normal controls and 126 infertile women were imaged by improved radionuclide hysterosalpingography (RNHS). Results: In the normal control group with small dose fractional injection of 99 Tc m -macroaggregated albumin (MAA) into cervical canal, the appearance time of radioactivity in ovarian tube by dynamic imaging was (4.0±2.7) s. When there was much more liquid retained in uterus, the ovarian appearance time delayed to (18.0±1.2) s. Combined the injection under pressure and second dynamic imaging in all 252 ovarian tubes of 126 cases, the damaged fallopian tubes could be divided into six patterns. Among all of the infertile women whose fallopian tubes showed mechanical patency by the X-ray hysterosalpingography (HSG), their positivity of damaged fallopian tube fuction reached 70.5% by RNHS. Besides, the mild and severe functional abnormality of fallopian tube in patients of primary and secondary infertility were 20.3% and 11.9% versus 14.9% and 17.9% respectively. Conclusion: Modified RNHS has important diagnostic value for judgment of the damage magnitude and patency of fallopian tube in infertile women. (authors)

Instruments for non-destructive evaluation of advanced test reactor inpile tubes

International Nuclear Information System (INIS)

Livingston, R.A.; Beller, L.S.; Edgett, S.M.

1986-01-01

The Advanced Test Reactor is a 250 MW LWR used primarily for irradiation testing of materials contained in inpile tubes that pass through the reactor core. These tubes provided the high pressure and temperature water environment required for the test specimens. The reactor cooling water surrounding the inpile tubes is at much lower pressure and temperature. The structural integrity of the inpile tubes is monitored by routine surveillance to ensure against unplanned reactor shutdowns to replace defective inpile tubes. The improved instruments developed for inpile tube surveillance include a bore profilometer, ultrasonic flaw detetion system and bore diameter gauges. The design and function of these improved instruments is presented

Destructive investigations of decommissioned guide tubes: characterization of wear

International Nuclear Information System (INIS)

Ambard, A.; Lina, A.; Bosselut, D.; Deforge, D.; Robinot, P.; Thebault, Y.; Paulhies, M.; Maingot, S.

2011-01-01

The wear of control rods has been a major maintenance concern for EDF since the nineties. Surface treatment of the rods (nitriding, chrome plating) were developed to deal with this issue. However, the question came to know whether the guiding tube in which those new control rods are inserted are also worn. EDF interest into guide tube wear has been renewed by the slow increase of the drop time in B06 position. EDF performed field examinations and some laboratory experiments to answer to this question. Two guide tubes were extracted from various cores. They were chosen due to their different positions within the core and the different nature of their counter bodies (different control rods surface treatment). Their continuous part were sliced to reduce their activity. Their dimensions were measured and compared to the nominal dimensions. Wear was evidenced with a low level. It is mainly concentrated around the notch. Some distinctions could be made depending on the guiding tube examined. Metallographic examinations were performed using SEM. The wear patterns of the guiding tubes appear similar from those of the control rods, which means that similar wear mechanisms must be involved. A tentative explanation of the increase of the rod drop time in position B06 is proposed. A tentative explanation of the low increase of rod drop time is presented. It could result from the conjunction of a larger pressing force in B06 position than in other position of the core as well as the conformal contact observed. The conformal contact in itself could results from the larger pressing force and the use of hardened rods. The findings of these field examinations have comforted EDF strategy concerning B06 guide tubes: they are changed before their drop time reaches a critical value. (authors)

Outcomes of Incidental Fallopian Tube High-Grade Serous Carcinoma and Serous Tubal Intraepithelial Carcinoma in Women at Low Risk of Hereditary Breast and Ovarian Cancer.

Science.gov (United States)

Chay, Wen Yee; McCluggage, W Glenn; Lee, Cheng-Han; Köbel, Martin; Irving, Julie; Millar, Joanne; Gilks, C Blake; Tinker, Anna V

2016-03-01

The natural history and optimal management of serous tubal intraepithelial carcinoma (STIC), regardless of BRCA status, is unknown. We report the follow-up findings of a series of incidental fallopian tube high-grade serous carcinomas (HGSCs) and STICs identified in women at low risk for hereditary breast and ovarian cancer (HBOC), undergoing surgery for other indications. Cases of incidental STIC and HGSC were identified from 2008. Patients with known BRCA1 or BRCA2 mutations, or a family history of ovarian or breast cancer before the diagnosis of STIC or HGSC were excluded. A retrospective chart review was conducted to obtain clinical data. Eighteen cases were identified with a median follow-up of 25 months (range, 4-88 months). Twelve of 18 patients had a diagnosis of STIC with no associated invasive HGSC and 6 had STIC associated with other invasive malignancies. Completion staging surgery was performed on 7 of the 18 patients, including 5 of 12 in which there was STIC only identified on primary surgery; 3 cases were upstaged from STIC only to HGSC based on the staging surgery. Recurrence of HGSC occurred in 2 of the 18 patients. BRCA testing was performed on 3 patients, 1 of whom tested positive for a pathogenic BRCA1 mutation. Our study suggests that completion staging surgery for incidental STICs in non-BRCA patients may be considered. These patients should be offered hereditary testing. The Pelvic-Ovarian cancer INTerception (POINT) Project is an international registry set up to add to our understanding of STICs.

Jose Cabrera (Zorita) tube examination

International Nuclear Information System (INIS)

Kuchirka, P.J.

1986-01-01

Jose Cabrera (Zorita) tube examination procedures are discussed. This plant continues to use phosphate water chemistry (sodium/phosphate ratio = 2.1). Three hot leg tube segments were pulled from the Jose Cabera (Zorita) plant in 1985. One tube had a field EC indication on the OD at the first tube support plate and the other two had field EC indications on their ID about 3 inches above the bottom of the tube sheet. All three tubes were initially sent to Battelle for preliminary NDE and decontamination. Segments of two tubes were sent to Westinghouse for destructive examination. The results of the laboratory eddy current and radiographic examinations are given. The results of the visual examinations are also given. The tube with OD indications was destructively examined and shallow intergranular pitting and intergranular attack, up to 2 mils deep, were found on the OD in the tube sheet region. Local areas of IGA, up to 5 mils deep, were found on the OD within the tube support plate region. A summary of this information together with supporting micrographs is given. It was hypothesized that a caustic crevice environment was the cause of this mild degradation. Shallow areas of thinning or wastage, up to 3 mils, were found just above the top of the tube sheet in the sludge pile region. Even more shallow wastage was found at the edges of support plate locations. This wastage is believed to be the remnant of early plant chemistry when a higher sodium/phosphate ratio and higher phosphate concentration were allowed

Hysterosalpingography

Medline Plus

Full Text Available ... called fluoroscopy to examine the uterus and fallopian tubes of a woman who is having difficulty becoming ... uterine fibroids. Hysterosalpingography can occasionally open blocked fallopian tubes to allow the patient to become pregnant afterwards. ...

Hysterosalpingography

Medline Plus

Full Text Available ... masses, adhesions and uterine fibroids. Hysterosalpingography can occasionally open blocked fallopian tubes to allow the patient to ... carrying a fetus to term. Hysterosalpingography can occasionally open fallopian tubes that are blocked allowing the patient ...

Tube-support response to tube-denting evaluation. Volume 1. Final report

International Nuclear Information System (INIS)

Anderson, P.L.; Hall, J.F.; Shah, P.K.; Wills, R.L.

1983-05-01

The response of the tube supports is one of the important considerations of tube denting in a steam generator. Investigations have indicated that damaged tube supports have the potential to distort and damage tubes. This investigation considers the response to tube denting of the Combustion Engineering type tube supports. Drilled support plates and eggcrate tube supports are tested in a model steam generator in which tube denting is induced. The experimental data is used to verify and refine analytical predictor models developed using finite element techniques. It was found that analytical models underpredicted the deformations of the tube supports and appropriate modifications to enhance the predictive capability are identified. Non-destructive examination methods are evaluated for application to operating steam generators. It was found that the standard eddy current and profilometry techniques are acceptable methods for determining tube deformations, but these techniques are not adequate to assess tube support damage. Radiography is judged to be the best available means of determining the extent and progression of damage in tube supports

Hysterosalpingography

Medline Plus

Full Text Available ... examine the uterus and fallopian tubes of a woman who is having difficulty becoming pregnant. It’s also ... uterosalpingography, is an x-ray examination of a woman's uterus and fallopian tubes that uses a special ...

Neutron image intensifier tubes

International Nuclear Information System (INIS)

Verat, M.; Rougeot, H.; Driard, B.

1983-01-01

The most frequently used techniques in neutron radiography employ a neutron converter consisting of either a scintillator or a thin metal sheet. The radiation created by the neutrons exposes a photographic film that is in contact with the converter: in the direct method, the film is exposed during the time that the object is irradiated with neutrons; in the transfer method, the film is exposed after the irradiation of the object with neutrons. In industrial non-destructive testing, when many identical objects have to be checked, these techniques have several disadvantages. Non-destructive testing systems without these disadvantages can be constructed around neutron-image intensifier tubes. A description and the operating characteristics of neutron-image intensifier tubes are given. (Auth.)

Incidental serous tubal intraepithelial carcinoma and early invasive serous carcinoma in the nonprophylactic setting: analysis of a case series.

Science.gov (United States)

Morrison, Jane C; Blanco, Luis Z; Vang, Russell; Ronnett, Brigitte M

2015-04-01

A precursor for invasive ovarian/pelvic high-grade serous carcinoma, termed serous tubal intraepithelial carcinoma (STIC), has been identified and characterized through careful analysis of the fallopian tubes in both prophylactic salpingo-oophorectomy specimens obtained from women with either a family history of breast and/or ovarian cancer or germline mutations of BRCA1 and BRCA2 and in cases of pelvic high-grade serous carcinoma. Data on incidental STICs and clinically occult microscopic invasive high-grade serous carcinomas are limited. We analyzed the clinicopathologic features of 22 cases, including 15 pure STICs and 7 STICs associated with microscopic invasive high-grade serous carcinomas, identified incidentally in fallopian tubes removed for nonprophylactic indications. Patient age ranged from 39 to 79 years (mean: 62.7; median: 61), with only 1 patient under the age of 50. No patients were known to carry BRCA1 or BRCA2 mutations. Of the 12 pure STICs for which the location in the fallopian tube could be established, 9 were in the fimbriated portion, 1 was at the junction of the fimbria and infundibulum, and 2 were in the nonfimbriated tube. Of the 7 STICs with associated invasive high-grade serous carcinoma, 3 were located in the fimbriated portion, 2 were at the junction of the fimbria and infundibulum, and 2 were in the nonfimbriated tube. The invasive components were in the fallopian tube in 6 cases, 4 in subepithelial stroma of tubal mucosa, and 2 as an intramucosal (exophytic) luminal lesion without invasion of underlying subepithelial stroma (size range: 1 to 4 mm). The remaining case had a microscopic focus of high-grade serous carcinoma within the ipsilateral ovary (1.3 mm cortical focus) identified only on deeper sections, without an associated invasive component in the fallopian tube. The preferential finding of atypical epithelium with the cytologic features of high-grade serous carcinoma, namely STIC, in the fallopian tubes rather than the

Acquired Salpingo-Enteric Fistula – A Case Report

African Journals Online (AJOL)

Erah

The result showed evidence of opacification of the right fallopian tube with contrast outlining the adjacent large bowels.Asymptomatic pelvic ... barium enema, vaginography, colpography, ultrasonography, computerized axial ... Figure 1: Initial HSG film showing contrast loculation in the right fallopian tube. to a suspicion of ...

TropJrnal Vol 32 No 1

African Journals Online (AJOL)

Mr Olusoji

INCISIONAL SCAR EVISCERATION OF FALLOPIAN TUBE IN A PREGNANT. WOMAN. 1. 2,. 3 ... Conclusion: Evisceration of a fallopian tube through an incisional hernia in a pregnant woman is an uncommon occurrence which is life threatening and prone to misdiagnoses. ... complicated with wound dehiscence and.

General Information about Ovarian Epithelial Cancer

Science.gov (United States)

... diagnosed, tests are done to find out if cancer cells have spread within the ovaries or to other parts of the body. The ... single ovary or fallopian tube. In stage IB, cancer is found inside both ovaries or fallopian tubes. In stage IC, cancer is ...

Hysterosalpingogram: an essential examination following Essure hysteroscopic sterilisation

Science.gov (United States)

Shah, V; Panay, N; Williamson, R; Hemingway, A

2011-01-01

Objectives The aim of this study was to describe our experience of imaging following hysteroscopic sterilisation with the Essure (Conceptus Inc., Mountain View, San Carlos, CA) microinsert, and to underline the importance of a carefully performed follow-up hysterosalpingogram (HSG) in the management of these patients. Methods 18 women underwent the procedure and all returned for follow-up HSG. A standard HSG technique was used and views were acquired to establish microinsert position and tubal occlusion. Results In 16 of the 18 women, adequate microinsert positioning and bilateral tubal occlusion was present. In one woman, a unilateral microinsert occluded the fallopian tube, whereas the other fallopian tube was ligated with a clip. The final patient underwent two studies; both showed well-positioned microinserts but unilateral free spill from the right fallopian tube. There are no reported pregnancies thus far. Conclusion Essure sterilisation coils have a unique appearance when radiographed and are an effective means of permanently occluding the fallopian tubes. HSG is a rapid and safe method of confirming satisfactory placement and tubal occlusion. Non-HSG imaging techniques are suboptimal at detecting patent fallopian tubes and expose patients to the risk of an unwanted and potentially complicated pregnancy. PMID:21123309

ISSN 2073 ISSN 2073-9990 East Cent. Afr. J. surg. (Online) 9990 ...

African Journals Online (AJOL)

DELL

adnexal mass, with normal cervix, uterus and endometrium, the differential diagnosis of fallopian tube carcinoma should be kept in mind. Introduction. Primary fallopian tube carcinoma is an uncommon tumor accounting for approximately 0.14% to. 1.8% of female genital malignancies1. The first classic case was reported in ...

A Combined Raindrop Aggregate Destruction Test-Settling Tube (RADT-ST Approach to Identify the Settling Velocity of Sediment

Directory of Open Access Journals (Sweden)

Liangang Xiao

2015-10-01

Full Text Available The use of sediment settling velocity based on mineral grain size distribution in erosion models ignores the effects of aggregation on settling velocity. The alternative approach, wet-sieved aggregate size distribution, on the other hand, cannot represent all destructive processes that eroded soils may experience under impacting raindrops. Therefore, without considering raindrop impact, both methods may lead to biased predictions of the redistribution of sediment and associated substances across landscapes. Rainfall simulation is an effective way to simulate natural raindrop impact under controlled laboratory conditions. However, very few methods have been developed to integrate rainfall simulation with the settling velocity of eroded sediment. This study aims to develop a new proxy, based on rainfall simulation, in order to identify the actual settling velocity distribution of aggregated sediment. A combined Raindrop Aggregate Destruction Test-Settling Tube (RADT-ST approach was developed to (1 simulate aggregate destruction under a series of simulated rainfalls; and (2 measure the actual settling velocity distribution of destroyed aggregates. Mean Weight Settling Velocity (MWSV of aggregates was used to investigate settling behaviors of different soils as rainfall kinetic energy increased. The results show the settling velocity of silt-rich raindrop impacted aggregates is likely to be underestimated by at least six times if based on mineral grain size distribution. The RADT-ST designed in this study effectively captures the effects of aggregation on settling behavior. The settling velocity distribution should be regarded as an evolving, rather than steady state parameter during erosion events. The combined RADT-ST approach is able to generate the quasi-natural sediment under controlled simulated rainfall conditions and is adequately sensitive to measure actual settling velocities of differently aggregated soils. This combined approach provides

Statistics applied to the testing of cladding tubes

International Nuclear Information System (INIS)

Perdijon, J.

1987-01-01

Cladding tubes, either steel or zircaloy, are generally given a 100 % inspection through ultrasonic non-destructive testing. This inspection may be completed beneficially with an eddy current test, as this is not sensitive to the same defects as those typically traced by ultrasonic testing. Unfortunately, the two methods (as with other non-destructive tests) exhibit poor precision; this means that a flaw, whose size is close to that denoted as rejection limit, may be accepted or rejected. Currently, rejection, i.e. the measurement above which a tube is rejected, is generally determined through measuring a calibration tube at regular time intervals, and the signal of a given tube is compared to that of the most recently completed calibration. This measurement is thus subject to variations which can be attributed to an actual shift of adjustments as well as to poor precision. For this reason, monitoring instrument adjustments using the so-called control chart method are proposed

Clinical application of hysterosalpingography with a double-lumen catheter of a contrast media combination consisting iohexol and saline

International Nuclear Information System (INIS)

Xi Jiayuan; Jiang Yong; Cao Xinhua; Zhu Ying; Lv Liang; Zhao Xinxiang; Wei Dingying; Shao Jingxuan; Hua Jian

2005-01-01

Objective: To evaluate the clinical value of hysteosalpingographic diagnosis in infertile women. Methods: After a catheter with a double-lumen saccule was inserted into the uterine cavity, saline or air of 2.5-3.5 ml was injected to fill the saccule. The filled saccule was inserted at the isthmus of uterus for blocking the internal orifice. The contrast medium was injected through the catheter into the uterine cavity and fallopian tubes to undertake hysterosalpingography and fallopian tube reopening. In case of fallopian tube obstruction, the injection pressure could be increased to obtain recanalization. All operations and selective imagings were carried out under TV supervision. Results: 2698 cases including 806 primary infertile women and 1868 secondary infertile women were examined by this method. Technical success rate was 99.5% with 2198 cases (81.9%) having normal uterus, 249 (9.3%) congenital abnormal uterus and 238 (8.9%) uterus diseases. The number of obstructed fallopian tube was 3028 with 117 serious hydropsy (3.8%). Ninety-eight cases had been examined with lipiodol hysterosalpingography in other hospitals with 35 cases still having lipiodol accumulated within the uterine cavities and fallopian tubes. No serious complications or death occurred except slight pain. Conclusions: Double-lumen cather with a contrast media combination of iohexol and saline for hysterosal pinography is safe, easy and effective, outcoming with excellent quality images. More information can be gained with this method than traditional lipiodol hyterosalpinography, and furthermore could have compression during radiogrophy and avoid the long term stasis of lipiodol. (authors)

Destruction of the arid plains by tubing in Kalmykia

Directory of Open Access Journals (Sweden)

V. P. Chichagov

2006-01-01

Full Text Available The expedition researches results of natural state after functioning of the water and oil extraction tubes on the territory of Kalmykia republic. It’s shown that any linear destroyment of the North-West Caspian plain makes complex activity of exogenic processes, main of which are: erosion, suffusion and deflation.

Hysterosalpingography

Medline Plus

Full Text Available ... of the fallopian tubes, and to monitor the effects of tubal surgery, including: Blockage of the fallopian ... ray examination. X-rays usually have no side effects in the typical diagnostic range for this exam. ...

Peritonitis due to genital tuberculosis

DEFF Research Database (Denmark)

Svendsen, Jesper Hastrup; Mikkelsen, A L; Siemssen, O J

1985-01-01

A case of genital tuberculosis is presented. The diagnosis was made by laparotomy and histological examination of biopsies from peritoneum and the Fallopian tube. The literature is reviewed and the diagnostic approach and treatment discussed.......A case of genital tuberculosis is presented. The diagnosis was made by laparotomy and histological examination of biopsies from peritoneum and the Fallopian tube. The literature is reviewed and the diagnostic approach and treatment discussed....

Hysterosalpingography

Medline Plus

Full Text Available ... Hysterosalpingography Hysterosalpingography uses a real-time form of x-ray called fluoroscopy to examine the uterus and fallopian ... is Hysterosalpingography? Hysterosalpingography, also called uterosalpingography, is an x-ray examination of a woman's uterus and fallopian tubes ...

SCC analysis of Alloy 600 tubes from a retired steam generator

Science.gov (United States)

Hwang, Seong Sik; Kim, Hong Pyo

2013-09-01

Steam generators (SG) equipped with Alloy 600 tubes of a Korean nuclear power plants were replaced with a new one having Alloy 690 tubes in 1998 after 20 years of operation. To set up a guide line for an examination of the other SG tubes, a metallographic examination of the defected tubes was carried out. A destructive analysis on 71 tubes was addressed, and a relation among the stress corrosion crack (SCC) defect location, defect depth, and location of the sludge pile was obtained. Tubes extracted from the retired SG were transferred to a hot laboratory. Detailed nondestructive analysis examinations were taken again at the laboratory, and the tubes were then destructively examined. The types and sizes of the cracks were characterized. The location and depth of the SCC were evaluated in terms of the location and height of the sludge. Most axial cracks were in the sludge pile, whereas the circumferential ones were around the top of the tube sheet (TTS) or below the TTS. Average defect depth of the axial cracks was deeper than that of the circumferential ones. Axial cracks at tube support plate (TSP) seem to be related with corrosion/sludge in crevice like at the TTS region. Circumferential cracks at TSP seem to be caused by tube denting at the upper part of the TSP. Tubes not having clear ECT signals for quantifying an ECT data-base. Tubes having no ECT signal. Tubes with a large ECT signal. Tubes with various types and sizes of flaws (primary water stress corrosion cracking (PWSCC), outside diameter stress corrosion cracking (ODSCC), Pit). Tubes with distinct PWSCC or ODSCC. Tubes were extracted from the RSG based on the field ECT with the criteria, and transferred to a hot laboratory at the Korea Atomic Energy Research Institute (KAERI) for destructive examination. A comprehensive ECT inspection was performed again at the hot laboratory to confirm the location of the cracks obtained from a field inspection. These exact locations of the defects were marked on the

The diagnosis and treatment of tubal pregnancy with selective salpingography

International Nuclear Information System (INIS)

Li Qunying

2000-01-01

Objective: To study feasibility of diagnosing and treating tubal pregnancy with selective salpingography. methods: 13 women diagnosed clinically as ectopic pregnancy without abdominal bleeding were studied and confirmed as tubal pregnancy with selective salpingography, MTX was then injected through fallopian tube. Urine hCG, blood β-hCG and US were studied during follow-up. Results: 12 cases tubal pregnancy were confirmed as well as 1 case of intra-uterine pregnancy. X-ray showed a localized dilation of fallopian tube, half-loop, ring-like or irregular shaped filling defect. In one case, cluster of grapes appearance of contrast medium could be seen at the umbrella end of fallopian tube. Of the 12 cases of tubal pregnancy, 10 were successfully treated, the successful rate was 83%. Conclusion: Selective salpingography is a simple safe and effective method of diagnosing and treating tubal pregnancy

a Study of Ultrasonic Wave Propagation Through Parallel Arrays of Immersed Tubes

Science.gov (United States)

Cocker, R. P.; Challis, R. E.

1996-06-01

Tubular array structures are a very common component in industrial heat exchanging plant and the non-destructive testing of these arrays is essential. Acoustic methods using microphones or ultrasound are attractive but require a thorough understanding of the acoustic properties of tube arrays. This paper details the development and testing of a small-scale physical model of a tube array to verify the predictions of a theoretical model for acoustic propagation through tube arrays developed by Heckl, Mulholland, and Huang [1-5] as a basis for the consideration of small-scale physical models in the development of non-destructive testing procedures for tube arrays. Their model predicts transmission spectra for plane waves incident on an array of tubes arranged in straight rows. Relative transmission is frequency dependent with bands of high and low attenuation caused by resonances within individual tubes and between tubes in the array. As the number of rows in the array increases the relative transmission spectrum becomes more complex, with increasingly well-defined bands of high and low attenuation. Diffraction of acoustic waves with wavelengths less than the tube spacing is predicted and appears as step reductions in the transmission spectrum at frequencies corresponding to integer multiples of the tube spacing. Experiments with the physical model confirm the principle features of the theoretical treatment.

Adnexal mass in tubal pregnancy

International Nuclear Information System (INIS)

Lee, Hee Jung; Kim, Jung Sik; Chu, Yang Ku

1993-01-01

Off the evaluation of clinical significance and pathologic correlation of echogenic adnexal mass in tubal pregnancy, which is separated from ipsilateral ovary, we performed a retrospective analysis of 15 proved tubal pregnancies. All showed hematosalpinx containing blood coagulum and chorionic villi with intact fallopian tube.The echogenicity of the adnexal mass was considered to represent the nonclotted or clotted blood within the fallopian tube. We conclude that the discrete, echogenic adnexal mass is the suggestive finding of unrupturedtubal pregnancy

A case of bilateral tubal pregnancy

Directory of Open Access Journals (Sweden)

Ayano Funamizu

2017-11-01

Full Text Available Bilateral tubal pregnancy is very rare and occurs in only 1 out of every 200,000 spontaneous pregnancies. In this case, a 29-year-old woman with a history of primary infertility underwent treatment with human menopausal gonadotropin (hMG-human chorionic gonadotropin (hCG, and became pregnant. A gestational sac (GS was not detected in the uterus and transvaginal ultrasonography (USG revealed GS with fetal heartbeat in the left adnexa at 7 weeks and 6 days of gestation. The patient underwent laparoscopic surgery and ultimately, bilateral tubal pregnancy was diagnosed. Consequently, bilateral fallopian tube resection was performed. Afterwards, she conceived by assisted reproductive technology (ART and delivered vaginally. This case suggests that even if a GS is found in one fallopian tube by USG, it is important to evaluate the other fallopian tube carefully. Keywords: bilateral tubal pregnancy, ectopic pregnancy, human menopausal gonadotropin, laparoscopy

Predicting microscopic extrauterine spread of endometrial carcinoma with MRI to support less invasive therapy

Energy Technology Data Exchange (ETDEWEB)

Oishi Tanaka, Yumiko; Nishida, Masato; Minami, Rie; Yamaguchi, Masayuki; Itai, Yuji [Tsukuba Univ., Ibaraki (Japan). Inst. of Clinical Medicine; Yoshizako, Takeshi

2000-06-01

Magnetic resonance imaging (MRI) provides precise staging of endometrial carcinoma. However, we have sometimes experienced patients with microscopic extrauterine extension in whom MRI showed the disease as being limited to the uterus. We studied indirect MRI signs for microscopic extrauterine spread of endometrial carcinoma which outwardly seemed to be limited to within the uterus. MRI studies and the clinical records of 100 patients with surgically proven endometrial carcinoma were retrospectively reviewed. We evaluated: MRI staging, tumor growing at the orifices of the fallopian tube in the uterine fundus, hydrosalpinx, and ascites, in each MRI study. Surgical specimens showed that 12 of the 100 patients had extrauterine spread, with 1 patient showing both ovarian extension and omental metastasis; there ovarian extension in 3, extension to the fallopian tubes in 3, omental metastasis in 1, and positive peritoneal cytology in 4. Tumor growing at the orifices of the fallopian tubes with deep myometrial invasion showed higher accuracy for predicting microscopic intrauterine spread (82.0%) although it was not significantly different from the accuracy of deep myometrial invasion anywhere within the uterus (75.0%). However, tumor growing at the orifices of the fallopian tubes in patients with stage Ia disease showed a high negative predictive value (89.7%). Hydrosalpinx had the highest specificity (98.9%) and accuracy (88.0%); however, it did not seem to be practical because it was observed in only 2 patients. Ascites in postmenopausal patients showed higher specificity (93.5%), although it was not considered to be useful in the premenopausal patients. Tumor extension at the orifices of the fallopian tubes in patients with stage Ia disease, and ascites in postmenopausal patients on MRI seemed to be predictive factors for microscopic extrauterine spread. (author)

Determination of zinc concentration in female reproductive system by instrumental neutron activation

International Nuclear Information System (INIS)

Carvalho, Fernando Ramos de

2009-01-01

Non-surgical female sterilization through the transcervical insertion of quinacrine pellets was considered a definitive, low-cost, safe and effective contraceptive method. The zinc, present in both uterus and Fallopian tubes, inhibit the quinacrine efficiency. The addition of copper increases the efficacy of quinacrine, reducing the risk of pregnancy due to the failure to obstruct the Fallopian tubes. The copper neutralized the deleterious effect of the zinc and so the treatment efficacy is increased. In order to obtain a mapping to study the zinc content in the female reproductive system, samples of both uterus and Fallopian tubes were analyzed by instrumental neutron activation. The results show that, on average, the obtained zinc concentrations in tubes (89 μg-g -1 ) is lower than in the uterus (118 μg-g -1 ), confirming results obtained by other authors. These results will support a research project about non-surgical female sterilization of the 'Faculdade de Medicina da Universidade Federal de Minas Gerais' (Medical School of Federal University of Minas Gerais). The used methodology and obtained results are here reported. (author)

Determination of zinc concentration in female reproductive system by instrumental neutron activation

Energy Technology Data Exchange (ETDEWEB)

Carvalho, Fernando Ramos de, E-mail: framosc@oi.com.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Dept. de Engenharia Nuclear; Oliveira, Arno Heeren de, E-mail: heeren@nuclear.ufmg.b [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Medicina. Dept. de Ginecologia e Obstetricia; Ferreira, Claudia R.C.; Ferreira, Ricardo Alberto Neto; Menezes, Maria Angela de B.C., E-mail: claudia@medicina.ufmg.b, E-mail: ranf@cdtn.b, E-mail: menezes@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

2009-07-01

Non-surgical female sterilization through the transcervical insertion of quinacrine pellets was considered a definitive, low-cost, safe and effective contraceptive method. The zinc, present in both uterus and Fallopian tubes, inhibit the quinacrine efficiency. The addition of copper increases the efficacy of quinacrine, reducing the risk of pregnancy due to the failure to obstruct the Fallopian tubes. The copper neutralized the deleterious effect of the zinc and so the treatment efficacy is increased. In order to obtain a mapping to study the zinc content in the female reproductive system, samples of both uterus and Fallopian tubes were analyzed by instrumental neutron activation. The results show that, on average, the obtained zinc concentrations in tubes (89 mug-g{sup -1}) is lower than in the uterus (118 mug-g{sup -1}), confirming results obtained by other authors. These results will support a research project about non-surgical female sterilization of the 'Faculdade de Medicina da Universidade Federal de Minas Gerais' (Medical School of Federal University of Minas Gerais). The used methodology and obtained results are here reported. (author)

Detection of ''beading faults'' in welded tubes

International Nuclear Information System (INIS)

Mondot, J.

In the steel tube industry the word ''beading'' refers to a highly localised leak affecting the welded zone. During the pneumatic test its flow rate is generally very low no more than a few thousandths of a mm 3 /second. Detection of such a fault by this test is consequently slow, and those which are choked or at the limit of leakage may escape detection. For greater safety, the tube technician is now using non-destructive testing methods such as eddy-currents and ultrasonics [fr

Actuality of histerosalpingography in women with infertilitas

International Nuclear Information System (INIS)

Tomala, J.; Witek, A.; Brudnik, A.

1993-01-01

In 283 women with infertility hysterosalpingographic (HSG) results have been analyzed. Fallopian tubes have been found to be patent in 196 subjects, whereas in 87 subjects distal or proximal unilateral or bilateral impatency has been observed. In 28 subjects with impatent fallopian tubes uterus malformations were found. 72 women with impatent oviducts were treated by laparoscopy alongside with oviduct chromotubation. On basis of clinical findings as well as cases reported in literature, HSG relevancy in infertility diagnostics has been proved. (author)

Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer

Science.gov (United States)

Tate, Tyler; Keenan, Molly; Swan, Elizabeth; Black, John; Utzinger, Urs; Barton, Jennifer

2014-12-01

The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six optical subsystems, two from OCT and four from MFI. The optical subsystems have independent and interrelated design criteria. The endoscope will be tested on realistic tissue models and ex vivo tissue to prove feasibility of future human trials. Ultimately the project aims to provide women the first effective ovarian cancer screening technique.

Fabrication characteristics of zircaloy tubes for nuclear reactors

International Nuclear Information System (INIS)

Haydt, H.M.

1980-11-01

The production sequence for zircaloy cladding tubes to be used in nuclear reactors is described, with emphasis on the texture after reduction and on the variation in the hydrides orientation. The qualities requested for the cladding tubes are presented and reference is made to the quality control applied in the process. The destructive tests as well as the final inspection to which those tubes are subjected are related. A Fabrication Quality Project is requested from the manufacturers by reason of what Quality Control Plans are submitted to be clients. At last an evaluation of the quality to be obtained and of the control performed is mentioned. (Author) [pt

Fatigue cracking on a steam generator tube

International Nuclear Information System (INIS)

Boccanfuso, M.; Lothios, J.; Thebault, Y.; Bruyere, B.; Duisabeau, L.; Herms, E.

2015-01-01

A circumferential fatigue crack was observed on a steam generator tube of the unit 2 of the Fessenheim plant. The results of destructive testing and the examination of the fracture surface show that the circumferential crack is linked to a large number of cycles with a very low stress intensity factor. Other aggravating factors like inter-granular corrosion have played a role in the initiating phase of fatigue cracking. The damage has been exacerbated by the lack of support of the tube at the level of the anti-vibration bars. (A.C.)

Method of processing spent fuel cladding tubes

International Nuclear Information System (INIS)

Nakatsuka, Masafumi; Ouchi, Atsuhiro; Imahashi, Hiromichi.

1986-01-01

Purpose: To decrease the residual activity of spent fuel cladding tubes in a short period of time and enable safety storage with simple storage equipments. Constitution: Spent fuel cladding tubes made of zirconium alloys discharged from a nuclear fuel reprocessing step are exposed to a grain boundary embrittling atmosphere to cause grain boundary destruction. This causes grain boundary fractures to the zirconium crystal grains as the matrix of nuclear fuels and then precipitation products precipitated to the grain boundary fractures are removed. The zirconium constituting the nuclear fuel cladding tube and other ingredient elements contained in the precipitation products are separated in this removing step and they are separately stored respectively. As a result, zirconium constituting most part of the composition of the spent nuclear fuel cladding tubes can be stored safely at a low activity level. (Takahashi, M.)

Non-destructive evaluation of stream generator tubes and pressure tubes from the PHWR reactors, using the rotating magnetic field method

International Nuclear Information System (INIS)

Premel, D.; Placko, D.; Grimberg, R.; Savin, A.

2001-01-01

This work presents a new type of eddy current transducer with a rotating magnetic field devoted to the inspection of steam generator tubes and pressure tubes from the PHWR reactors. A theoretical model has been developed that permits the calculations of the emf induced in the reception coils in the presence of the copper or magnetite deposits, anti-vibration railing and garter springs. (authors)

Pregnancy after hydrosalpinx treatment with Essure

Science.gov (United States)

Inocêncio, Gonçalo; Coutinho, Lúcia; Maciel, Raquel; Barreiro, Márcia

2013-01-01

We present a case of a 29-year-old woman, with a history of ectopic pregnancy, which required left salpingectomy, and with a tortuous and impermeable right fallopian tube, compatible with hydrosalpinx. As hydrosalpinx itself can compromise a future pregnancy, treatment with Essure was proposed before passing to medically assisted procreation techniques. Five months after placement of Essure in the right fallopian tube, an in vitro fertilisation cycle was successfully completed and the woman had a singleton pregnancy and vaginal delivery without intercurrences. PMID:23536627

Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma.

Science.gov (United States)

Ducie, Jennifer; Dao, Fanny; Considine, Michael; Olvera, Narciso; Shaw, Patricia A; Kurman, Robert J; Shih, Ie-Ming; Soslow, Robert A; Cope, Leslie; Levine, Douglas A

2017-10-17

Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are the putative precursor to HGSC and identifiable in ~ 50% of advanced stage cases. To better understand the molecular etiology of HGSCs, we report a multi-center integrated genomic analysis of advanced stage tumors with and without STIC lesions and normal tissues. The most significant focal DNA SCNAs were shared between cases with and without STIC lesions. The RNA sequence and the miRNA data did not identify any clear separation between cases with and without STIC lesions. HGSCs had molecular profiles more similar to normal fallopian tube epithelium than ovarian surface epithelium or peritoneum. The data suggest that the molecular features of HGSCs with and without associated STIC lesions are mostly shared, indicating a common biologic origin, likely to be the distal fallopian tube among all cases.High-grade serous carcinomas (HGSCs) are associated with precursor lesions (STICs) in the fallopian epithelium in only half of the cases. Here the authors report the molecular analysis of HGSCs with and without associated STICs and show similar profiles supporting a common origin for all HGSCs.

Pre-hysterectomy assessment of immediate tubal occlusion with the third-generation ESSURE insert (ESS505).

Science.gov (United States)

Thiel, John; Rattray, Darrien; Cher, Daniel J

2014-01-01

To assess the ability of a new iteration of the ESSURE insert (ESS505) to achieve short-term fallopian tube occlusion. Prospective, single center, interventional cohort (Canadian Task Force classification II-1). Tertiary care hospital. Women scheduled to undergo hysterectomy. Patients underwent placement of the ESS505 in the right fallopian tube and ESS305 (the commercially approved previous version of the device) in the left fallopian tube at 30 (n = 10), 60 (n = 10), or 90 (n = 10) days before a planned hysterectomy. Tubal occlusion was assessed via hysterosalpingography (HSG) both at the time of placement and just before hysterectomy. Ultrasound was used to evaluate acute device placement. Thirty-five women (mean age, 39.7 years) were enrolled from July 2012 to January 2013, and 30 underwent both ESSURE placement and scheduled hysterectomy. Mean (SD) placement time for the ESS305 and ESS505 devices was 1.4 (0.65) minutes and 1.3 (0.42) minutes, respectively (p = .36). At 1 hour after ESS505 placement, 29 of 30 tubes (97%) exhibited complete occlusion at HSG, compared with only 4 of 30 tubes (13%) after ESS305 placement (p ESSURE placement. Copyright © 2014 AAGL. Published by Elsevier Inc. All rights reserved.

Experimentally Evaluated Explosion Resistance and Performance of Destruction Unit in Multiple Detonation of Ammunition

Directory of Open Access Journals (Sweden)

P. A. Baskakov

2016-01-01

Full Text Available The paper presents results of development and experimental investigation of explosion resistance and destruction unit performance in multiple detonation of ammunition with an explosive weight up to 0.7 kg of TNT. A preliminary evaluation of the explosion resistance was carried out using a model of explosion resistance localizer, represented as a thick-walled tube. As a result of explosive tests, the nature and characteristics of tube deformation under repeated explosions have been revealed. The findings allowed us to develop the first embodiment of the destruction unit with a turning non-separable heater and a two-layer localizer, which was heated by the induction field. The explosive life tests have revealed the following drawbacks: low resource localizer, jamming rotating mechanism in contact with the splinters, and impossible replacement of damaged localizer. In the second embodiment of the destruction unit a plate-assembled easychange localizer is mounted on the heater, and it is heated by heat transfer from the core. Tests have shown that, with such a placement, the uniform heating of the localizer is not reached. This leads to incomplete destruction of ammunition. Besides, because of the low strength of the pins connecting the plates, occurrs their rapid destruction. Taking into consideration the shortcomings of the previous two designs, the third option of the destruction unit with a replaceable localizer and induction heating of a localizer has been designed. A localizer material having high mechanical strength at high temperatures and good ferromagnetic properties has been selected. The paper offers an all-metal localizer design with the thickest wall at the bottom that is the most damageable. The paper has experimentally determined a critical deformation of the localizer when destroying the ammunition with varying weight of explosive and defined the heater and bump resource. As a result, the work proposes the destruction unit design

N Reactor pressure tube 1350 postirradiation examination

International Nuclear Information System (INIS)

Cook, D.J.

1977-01-01

The N Reactor pressure tubes were fabricated from Zircaloy-2 primarily due to the excellent corrosion resistance, low neutron absorption, and high strength properties of this alloy. Irradiation damage mechanisms increase the strength and decrease the ductility of the Zircaloy-2. Irradiation data available at the time the tubes were installed indicated that fast neutron irradiation damage mechanisms would not decrease the ductility to unacceptable levels over the estimated plant life of 25 to 30 years. However, because the tubes are a primary coolant system component and only limited data are available on irradiation effects at high fluences, a Postirradiation Examination (PIE) program was developed to assure that service factors do not compromise pressure tube integrity essential to reactor safety. The PIE program requires that a pressure tube be periodically removed from the reactor for destructive testing. The N Reactor Technical Specifications specify that the frequency of pressure tube removal and examination be based upon the previous PIE test results. Four pressure tubes were examined before tube 1350, and the test results were summarized in individual reports. PIE results on tube 1350 were summarized along with the test results on the previous four tubes in a previous report. The purpose of this report is to present in detail the results on PIE of pressure tube 1350, and, in particular, document the technique by which the fracture toughness of the pressure tube was determined

Development of ultrasonic heat transfer tube thickness measurement apparatus. Contract research

Energy Technology Data Exchange (ETDEWEB)

Ohba, Toshihiro; Katoh, Chiaki; Yanagihara, Takao [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Suetugu, Hidehiko; Yano, Masaya [Sumitomo Chemical Co., Ltd., Tokyo (Japan)

2003-01-01

The demonstration test for evaluating reliability of the acid recovery evaporator at Rokkasho Reprocessing Plant has been carried out at JAERI. For the nondestructive measurement of the thickness of heat transfer tubes of the acid recovery evaporator in corrosion test, we have developed thickness measurement apparatus for heat transfer tubes by ultrasonic immersion method with high resolution. The ultrasonic prove in a heat transfer tube can be moved vertically and radially. The results obtained by this apparatus coincident well with those obtained by a destructive method using an optical microscope. (author)

Environmentally friendly joining of tubes by their ends

DEFF Research Database (Denmark)

Silva, Carlos M.A.; Nielsen, Chris Valentin; Alves, Luis M.

2015-01-01

This paper proposes an environmentally friendly joining process for connecting tubes by their ends that has the potential to replace current solutions based on fastened, crimped, welded, brazed or adhesive bonded joints. The process is based on a new type of tubular lap joint produced by local...... of deformation and the process feasibility window, and destructive testing to establish the working limits of tubular lap joints under different type of loading conditions. Results demonstrate that the proposed joining process is a flexible and cost-effective technology for connecting tubes by their ends...

Evaluation of hydride blisters in zirconium pressure tube in CANDU reactor

International Nuclear Information System (INIS)

Cheong, Y. M.; Kim, Y. S.; Gong, U. S.; Kwon, S. C.; Kim, S. S.; Choo, K.N.

2000-09-01

When the garter springs for maintaining the gap between the pressure tube and the calandria tube are displaced in the CANDU reactor, the sagging of pressure tube results in a contact to the calandria tube. This causes a temperature difference between the inner and outer surface of the pressure tube. The hydride can be formed at the cold spot of outer surface and the volume expansion by hydride dormation causes the blistering in the zirconium alloys. An incident of pressure tube rupture due to the hydride blisters had happened in the Canadian CANDU reactor. This report describes the theoretical development and models on the formation and growth of hydride blister and some experimental results. The evaluation methodology and non-destructive testing for hydride blister in operating reactors are also described

Evaluation of hydride blisters in zirconium pressure tube in CANDU reactor

Energy Technology Data Exchange (ETDEWEB)

Cheong, Y M; Kim, Y S; Gong, U S; Kwon, S C; Kim, S S; Choo, K N

2000-09-01

When the garter springs for maintaining the gap between the pressure tube and the calandria tube are displaced in the CANDU reactor, the sagging of pressure tube results in a contact to the calandria tube. This causes a temperature difference between the inner and outer surface of the pressure tube. The hydride can be formed at the cold spot of outer surface and the volume expansion by hydride dormation causes the blistering in the zirconium alloys. An incident of pressure tube rupture due to the hydride blisters had happened in the Canadian CANDU reactor. This report describes the theoretical development and models on the formation and growth of hydride blister and some experimental results. The evaluation methodology and non-destructive testing for hydride blister in operating reactors are also described.

Feasibility of dynamic MR-hysterosalpingography for the diagnostic work-up of infertile women

International Nuclear Information System (INIS)

Winter, Leopold; Gluecker, Thomas; Steinbrich, Wolfgang; Pegios, Wassilios; Steimann, Sabine; De Geyter, Christian; Froehlich, Johannes M.

2010-01-01

Background: Tubal disturbances often contribute to infertility. Conventional hysterosalpingography (HSG) is considered as standard in the assessment of the patency of the fallopian tubes, but requires ionizing radiation and is restricted to the imaging of endoluminal structures. Purpose: To evaluate dynamic magnetic resonance-HSG (dMR-HSG) in the diagnostic work-up in patients with infertility. Material and Methods: Thirty-seven consecutive infertile women underwent dMR-HSG: 20 ml of gadolinium-polyvidone solution (18.4 mM Dotarem 1:20 with polyvidone) were injected intracervically through a 5-Charriere balloon catheter while acquiring five consecutive flash-3D T1-weighted MR sequences with fat saturation. Two experienced readers assessed image quality and anatomic-pathologic correlations prospectively. The relevance of results was evaluated in the clinical context of each patient. Patient comfort was evaluated with a standardized questionnaire. Results: dMR-HSG was successfully completed in 33/37 patient with an average study time of 45 min. In 4 of 37 patients the catheter became dislodged during the examination, resulting in two complete diagnostic failures. Failure in another two patients was due to preliminary termination because of excessive pain and discomfort during the application of the contrast solution. The uterine cavity was completely visualized and bilateral fallopian tube patency was confirmed by dMR-HSG in 27 of 33 patients. Bilateral tubal occlusion was diagnosed in one of the remaining six patients and was confirmed by laparoscopy. Successful selective tubal catheterization was performed in one additional patient with unilateral and one patient with bilateral fallopian tube occlusion. In three cases, the catheter became dislocated at the end of the examination without demonstration of tubal patency. Since all three patients refused diagnostic laparoscopy and conventional HSG, possible bilateral occlusions of the fallopian tubes could not be

Feasibility of dynamic MR-hysterosalpingography for the diagnostic work-up of infertile women

Energy Technology Data Exchange (ETDEWEB)

Winter, Leopold; Gluecker, Thomas; Steinbrich, Wolfgang; Pegios, Wassilios (Dept. of Radiology, Univ. Hospital Basel (Switzerland)), e-mail: winterl@uhbs.ch; Steimann, Sabine; De Geyter, Christian (Women' s Hospital, Univ. Hospital Basel (Switzerland)); Froehlich, Johannes M. (Guerbet AG, Zuerich (Switzerland))

2010-07-15

Background: Tubal disturbances often contribute to infertility. Conventional hysterosalpingography (HSG) is considered as standard in the assessment of the patency of the fallopian tubes, but requires ionizing radiation and is restricted to the imaging of endoluminal structures. Purpose: To evaluate dynamic magnetic resonance-HSG (dMR-HSG) in the diagnostic work-up in patients with infertility. Material and Methods: Thirty-seven consecutive infertile women underwent dMR-HSG: 20 ml of gadolinium-polyvidone solution (18.4 mM Dotarem 1:20 with polyvidone) were injected intracervically through a 5-Charriere balloon catheter while acquiring five consecutive flash-3D T1-weighted MR sequences with fat saturation. Two experienced readers assessed image quality and anatomic-pathologic correlations prospectively. The relevance of results was evaluated in the clinical context of each patient. Patient comfort was evaluated with a standardized questionnaire. Results: dMR-HSG was successfully completed in 33/37 patient with an average study time of 45 min. In 4 of 37 patients the catheter became dislodged during the examination, resulting in two complete diagnostic failures. Failure in another two patients was due to preliminary termination because of excessive pain and discomfort during the application of the contrast solution. The uterine cavity was completely visualized and bilateral fallopian tube patency was confirmed by dMR-HSG in 27 of 33 patients. Bilateral tubal occlusion was diagnosed in one of the remaining six patients and was confirmed by laparoscopy. Successful selective tubal catheterization was performed in one additional patient with unilateral and one patient with bilateral fallopian tube occlusion. In three cases, the catheter became dislocated at the end of the examination without demonstration of tubal patency. Since all three patients refused diagnostic laparoscopy and conventional HSG, possible bilateral occlusions of the fallopian tubes could not be

Olaparib

Science.gov (United States)

... maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue ...

The comparison of interventional tubal recanalization and drug irrigation recanalization in the management of oviduct obstruction

International Nuclear Information System (INIS)

Zhang Xiaomin; Li Yuzhi

2002-01-01

Objective: To explore and compare the efficacy of the interventional and drags irrigation tube recanalization for infertile women with fallopian tube obstruction. Methods: Eighteen patients with 36 tubal obstructions in the research group were treated with interventional tube recanalization and drugs infusion into tube through catheter. Other 10 cases with 20 tubal obstructions in the comparison group were treated only with drugs irrigation. All cases received followed up examination in 6 mouths. Results: The successful rates of recanalization were 61.1% (22/36) in the research group and 30.0% (6/20) in the comparison group, respectively. There was significant difference between the two groups (P < 0.05). The recurrence was 4 tube in the research group, 1 tube in the comparison group six months. Conclusion: The interventional tubal recanalization is a simple, sate and more effective treatment method of choice compared with the tubal recanalization with the traditional drag irrigation for fallopian tube obstruction

A rare cause of acute abdominal pain in children: Isolated tubal torsion; a case series

Directory of Open Access Journals (Sweden)

Yasemin Dere Gunal

2017-06-01

Full Text Available Isolated tubal torsion -a rare cause of acute abdomen in children-is usually difficult to diagnose because of non-specific findings. Surgical salphingectomy is required in delayed diagnosis in most cases. Three sexual inactive adolescents diagnosed in isolated tubal torsion (ITT were discussed for its diagnostic features and surgical management. Laboratory tests and radiological studies including ultrasonography (US, color doppler ultrasound were performed in all patients after evaluation for acute lower abdominal pain in emergency department and they underwent surgical intervention with laparotomy (n:2 and laparoscopy (n:1. One of the patients in this study had salpingectomy. Detorsion of the fallopian tube and cyst excision were performed in the remaining two patients who also had paratubal cysts. There was no recurrence in these patients during the follow-up for 3 and 2 years. The isolated tubal torsion should be kept in mind and early surgical management is essential in order to preserve fallopian tube because of its importance in fertility. Keywords: Fallopian tube, Torsion, Paratubal cyst, Adolescent, Acute abdomen

Probabilistic methodology for assessing steam generator tube inspection - Phase II: CANTIA - a probabilistic method for assessing steam generator tube inspections

International Nuclear Information System (INIS)

Harris, J.E.; Gorman, J.A.; Turner, A.P.L.

1997-03-01

The objectives of this project were to develop a computer-based method for probabilistic assessment of inspection strategies for steam generator tubes, and to document the source code and to provide a user's manual for it. The program CANTIA was created to fulfill this objective, and the documentation and verification of the code is provided in this volume. The user's manual for CANTIA is provided as a separate report. CANTIA uses Monte Carlo techniques to determine approximate probabilities of steam generator tube failures under accident conditions and primary-to-secondary leak rates under normal and accident conditions at future points in time. The program also determines approximate future flaw distributions and non-destructive examination results from the input data. The probabilities of failure and leak rates and the future flaw distributions can be influenced by performing inspections of the steam generator tubes at some future points in time, and removing defective tubes from the population. The effect of different inspection and maintenance strategies can therefore be determined as a direct effect on the probability of tube failure and primary-to-secondary leak rate

Distillation, destructive

Energy Technology Data Exchange (ETDEWEB)

Young, W; Fyfe, J

1897-06-03

Improvements in retorts of the class described in Specification No. 1377, A. D. 1882, for the destructive distillation of shale are disclosed. The retorts are provided with enlarged multiple hoppers for the reception of the fresh shale, and with enlarged chambers for the reception of the exhausted shale. The hoppers are built up of steel plates, and are bolted at the bottom to flanges on the upper ends of the retorts so as to permit of differential expansion. The shale is fed continuously into the retorts by rods or chains carried by a rocking shaft, or by a slit tube attached to a rocking shaft, and in connection with the hydraulic main. The spent shale is discharged into the receiving chambers by means of a series of prongs extending through a grating and carried by a rocking shaft actuated by levers engaging with reciprocating bars. In an alternative arrangement, the pronged rocking shafts are replaced by worms or screws formed into one half with a right-hand thread and the other half with a left-hand thread.

Transvaginal sonography of acute pelvic inflammatory disease

International Nuclear Information System (INIS)

Choi, Jin Soo; Kim, Young Hwa; Shin, Hyung Chul; Han, Gun Soo; Kim, Il Young

1999-01-01

To determine the value of transvaginal sonography in evaluating women with acute pelvic inflammatory disease (PID). Transvaginal sonography was performed in 25 patients with clinically suggested PID during recent 36 months. The sonographic findings of fallopian tubes and ovaries were analyzed and correlated with pathological findings of 2 fallopian tubes and 19 ovaries in 16 patients who had operations. The correct diagnosis of acute PID was made in 20/25 (80%) by transvaginal sonography. the abnormal sonographic findings of the fallopian tube include tubal thickening or dilatation with internal echo. The sensitivity, specificity, and accuracy for tubal abnormality were 88%, 96%, and 86% , respectively. Ovarian changes were seen on TVS in 14/19 (73%), which include multiple follicular enlargement in 5, tubo-ovarian complex in 9 (tubo-ovarian adhesion in 3, tubo-ovarian abscess in 6). At surgery, the ovay was not involved in all three women who showed tubo-ovarian adhesion on TVS. Among 6 women who showed tubo-ovarian abscess on TVS, tubo-ovarian abscess was confirmed in 3 and the remaining 3 had ovarian cysts. Trandvaginal sonography, a facilitative and accurate modality, is highly sensitive in detecting the abnormality of the tube and useful in differentiating the tubo-ovarian complex in patients with acute PID.

PATTERNS OF SEVEN AND COMPLICATED MALARIA IN CHILDREN

African Journals Online (AJOL)

GB

2015-10-04

Oct 4, 2015 ... ovaries are of normal size and fallopian tubes are normal; rudimentary uterine horns may be present in this syndrome (4-6). The etiologic .... post-conception age results in muscular thickening at the proximal end of each tube ...

Magnetic evaluation of the external surface in cast heat-resistant steel tubes with different aging states

Science.gov (United States)

Arenas, Mónica P.; Silveira, Rosa M.; Pacheco, Clara J.; Bruno, Antonio C.; Araujo, Jefferson F. D. F.; Eckstein, Carlos B.; Nogueira, Laudemiro; de Almeida, Luiz H.; Rebello, João M. A.; Pereira, Gabriela R.

2018-06-01

Heat-resistant austenitic stainless steels have become the principal alloys for use in steam reformer tubes in the petrochemical industry due to its mechanical properties. These tubes are typically exposed to severe operational conditions leading to microstructural transformations such as the aging phenomenon. The combination of high temperatures and moderate stresses causes creep damages, being necessary to monitor its structural condition by non-destructive techniques. The tube external wall is also subjected to oxidizing atmospheres, favoring the formation of an external surface, composed by an oxide scale and a chromium depleted zone. This external surface is usually not taken into account in the tube evaluation, which can lead to erroneous estimations of the service life of these components. In order to observe the magnetic influence of this layer, two samples, exposed to different operational temperatures, were characterized by non-destructive eddy current testing (ECT), scanning DC-susceptometer and magnetic force microscopy (MFM). It was found that the external surface thickness influences directly in the magnetic response of the samples.

Development of weld plugging for steam generator tubes of FBR

International Nuclear Information System (INIS)

Shimoyama, T.; Matsuyama, T.; Matsumoto, O.; Nagura, Y.; Nakamura, H.; Tohguchi, Y.; Kurokawa, M.; Fukada, T.

2002-01-01

This study was undertaken to develop a method of weld plugging of the heat-exchanger tubes of steam generator of Prototype FBR 'MONJU' in case these tubes are damaged for some reason. We studied mainly the shape of plug, welding procedure and effect of postweld heat treatment (PWHT). Evaporator tube sheet, tube and plug are made of 2-1/4Cr-1Mo steel and usually preheating and PWHT will be required for welding of this steel. The results of this study is as follows. 1) Plug was designed to make butt joint welding with grooved tube sheet around the tube hole to satisfy the requirements of plug designing, stress analysis, and good weldability. 2) TIG welding process was selected and certified its good weldability and good performance. 3) PWHT can be done by using high frequency induction heating method locally and also designing the plug to weld joint with tube sheet which was grooved around the tube hole. 4) Mock up test was done and it was certified that this plugging procedure has good weldability and good performance ability for Non Destructive Inspection. (author)

Papillary Tubal Hyperplasia. The Putative Precursor of Ovarian Atypical Proliferative (Borderline) Serous Tumors, Noninvasive Implants and Endosalpingiosis

Science.gov (United States)

Kurman, Robert J.; Vang, Russell; Junge, Jette; Hannibal, Charlotte Gerd; Kjaer, Susanne K.; Shih, Ie-Ming

2011-01-01

In contrast to the controversy regarding the terminology and behavior of ovarian noninvasive low-grade serous tumors (atypical proliferative serous tumor [APST] and serous borderline tumor [SBT]), little attention has been directed to their origin. Similarly, until recently, proliferative lesions in the fallopian tube have not been extensively studied. The recent proposal that ovarian high-grade serous carcinomas are derived from intraepithelial carcinoma in the fallopian tube prompted us to evaluate the possible role of the fallopian tube in the genesis of low-grade serous tumors. We have identified a lesion, designated “papillary tubal hyperplasia (PTH)”, characterized by small rounded clusters of tubal epithelial cells and small papillae, with or without associated psammoma bodies, that are present within the tubal lumen and which are frequently associated with APSTs. Twenty-two cases in this study were selected from a population-based study in Denmark of approximately 1000 patients with low-grade ovarian serous tumors in whom implants were identified on the fallopian tube. Seven additional cases were seen recently in consultation at The Johns Hopkins Hospital (JHH). These 7 cases were not associated with an ovarian tumor. Papillary tubal hyperplasia was found in 20 (91%) of the 22 cases in the Danish study. Based on this association of PTH with APSTs with implants and the close morphologic resemblance of PTH, not only to the primary ovarian APSTs but also to the noninvasive epithelial implants and endosalpingiosis, we speculate that the small papillae and clusters of cells from the fallopian tubes implant on ovarian and peritoneal surfaces to produce these lesions. The 7 JHH cases of PTH that were not associated with an ovarian tumor support the view that PTH is the likely precursor lesion. We propose a model for the development of ovarian and extraovarian low-grade serous proliferations (APST, noninvasive epithelial implants and endosalpingiosis) that

Immunohistochemical localization of HE4 in benign, borderline, and malignant lesions of the ovary.

Science.gov (United States)

Georgakopoulos, Penelope; Mehmood, Saira; Akalin, Ali; Shroyer, Kenneth R

2012-11-01

Despite advances in the development of novel methods to improve treatment, ovarian carcinoma is still the leading cause of gynecologic cancer death in the United States and other industrialized nations. Improvements in the clinical outcome of ovarian cancer will be achieved if methods can be developed to enable the detection of these tumors at the earliest possible stage. Thus, it is critically important to identify and validate new biomarkers of ovarian cancer. HE4 expression was defined by immunohistochemical analysis of a wide range of benign, borderline, and malignant ovarian lesions, including serous, endometrioid, mucinous, and clear cell lesions of the ovary and in primary tubal carcinomas and the normal fallopian tube. At the cellular level, HE4 was highly expressed in malignant ovarian tumors and in a wide range of benign and borderline ovarian lesions. In addition, HE4 was highly expressed in primary fallopian tube carcinomas and benign fallopian tubal epithelial cells. These results support the conclusion that HE4 is widely expressed in most benign, borderline, and malignant lesions of the ovary and the fallopian tube. The detection of HE4 expression at high levels in some benign lesions and normal tissues suggests that HE4 could have limited specificity as a marker of ovarian or tubal carcinoma. Furthermore, the relatively weak expression that was observed in many ovarian carcinomas indicates that HE4 could fail to detect some cases of primary or recurrent disease.

Three-photon imaging of ovarian cancer

Science.gov (United States)

Barton, Jennifer K.; Amirsolaimani, Babak; Rice, Photini; Hatch, Kenneth; Kieu, Khanh

2016-02-01

Optical imaging methods have the potential to detect ovarian cancer at an early, curable stage. Optical imaging has the disadvantage that high resolution techniques require access to the tissue of interest, but miniature endoscopes that traverse the natural orifice of the reproductive tract, or access the ovaries and fallopian tubes through a small incision in the vagina wall, can provide a minimally-invasive solution. We have imaged both rodent and human ovaries and fallopian tubes with a variety of endoscope-compatible modalities. The recent development of fiber-coupled femtosecond lasers will enable endoscopic multiphoton microscopy (MPM). We demonstrated two- and three-photon excited fluorescence (2PEF, 3PEF), and second- and third-harmonic generation microscopy (SHG, THG) in human ovarian and fallopian tube tissue. A study was undertaken to understand the mechanisms of contrast in these images. Six patients (normal, cystadenoma, and ovarian adenocarcinoma) provided ovarian and fallopian tube biopsies. The tissue was imaged with three-dimensional optical coherence tomography, multiphoton microscopy, and frozen for histological sectioning. Tissue sections were stained with hematoxylin and eosin, Masson's trichrome, and Sudan black. Approximately 1 μm resolution images were obtained with an excitation source at 1550 nm. 2PEF signal was absent. SHG signal was mainly from collagen. 3PEF and THG signal came from a variety of sources, including a strong signal from fatty connective tissue and red blood cells. Adenocarcinoma was characterized by loss of SHG signal, whereas cystic abnormalities showed strong SHG. There was limited overlap of two- and three- photon signals, suggesting that three-photon imaging can provide additional information for early diagnosis of ovarian cancer.

Case Report: Laparoscopic Approach for Orchiopexy in a 26-Year-Old Man with Accidentally Discovered Persistent Müllerian Duct Syndrome and Bilateral Undescended Testis.

Science.gov (United States)

Noureldin, Mohamed Essam; Tawfik, Ahmed Mohamed; Shaker, Hassan S

2018-01-01

Background: Persistent Müllerian duct syndrome (PMDS) is not a common form of disorder of sex development in which Müllerian duct derivatives (fallopian tubes, uterus, and the proximal vagina) are present in an otherwise normally differentiated 46 XY male. In most of cases, the challenge comes in the procedure of orchiopexy. Case Presentation: We report a case of a 26-year-old man with PMDS. It was accidentally discovered when the patient presented to our outpatient clinic concerning about his empty scrotum as a premarital check. Diagnostic laparoscopy discovered Mullerian remnants in the form of uterus, cervix, and fallopian tubes with two attached testes to the fallopian tubes. Staged laparoscopic orchiopexy was done. We discuss the presentation, the management of this case in the literature, and our intervention. Conclusion: PMDS is not a common condition. Several concerns present in the management of these cases. Malignant transformation of the testis is the main risk facing those patients. Few literature studies discussed the risk of changing of these remnants into malignant tissue. Thus discussion with the patient, tissue histopathology, expert opinions, and literature review are the main clues in management of such cases.

Quality assurance and quality control in fabrication of heat exchanger tubes

International Nuclear Information System (INIS)

Duennewald, A.

1980-01-01

Object of this report is the manufacture of heat exchanger tubes. A comprehensive manufacturing and test program has to be established to assure and prove and equal tube quality. This requires a functionally operating quality assurance system combined with a production exactly planned in advance. A specific continuous production line for heat exchanger tubes has been erected at the Hellenthal plant of the Mannesmannroehren-Werke. All production steps and heat treatments are generally controlled by a quality control department. Non-destructive testing of each tube produced in standard length is performed on several agregates in line using ultrasonic and/or eddy current technique. All tests are generally performed in the presence of quality inspectors or surveyors. For a lot of heat exchangers the straight tubes have to be hairpin bended. To avoid the risk of stress corrosion cracking, it is recommended to procreate defined compression stresses in the outside tube surface. Prior to releasing the tubes to shipment, the completeness of the documentation as to the manufacturing steps and inspection agreed upon is thoroughly checked. (RW)

Leak on a steam generator tube: in-depth analysis

International Nuclear Information System (INIS)

Berger, J.; Deotto, G.; Mathon, C.; Madurel, A.; Pitner, P.; Gay, N.; Guivarch, M.

2015-01-01

A circumferential through crack was observed on a steam generator tube of the unit 2 of the Fessenheim plant. Destructive tests showed that the crack was due to cycle fatigue combined with the presence of inter-granular corrosion zones. An in-depth analysis based on simulations shows that the combination of 5 elements caused the crack. First, a specific position of the anti-vibration bar near this tube, secondly, a local presence of fouling, these 2 first elements led to an increase of the tube vibratory level. Thirdly, the 600 MA alloy used is known to be susceptible to corrosion. Fourthly, the trapping of chemical species on the secondary circuit side due to the presence of interstices on the crosspiece and fifthly, the presence of spots where inter-granular corrosion developed. (A.C.)

Reliability of eddy current examination of steam generator tubes

International Nuclear Information System (INIS)

Birks, A.S.; Ferris, R.H.; Doctor, P.G.; Clark, R.A.; Spanner, G.E.

1985-04-01

A unique study of nondestructive examination reliability is underway at the Pacific Northwest Laboratory under US Nuclear Regulatory Commission sponsorship. Project participants include the Electric Power Research Institute and consortiums from France, Italy, and Japan. This study group has conducted a series of NDE examinations of tubes from a retired-from-service steam generator, using commercially available multifrequency eddy current equipment and ASME procedures. The examination results have been analyzed to identify factors contributing to variations in NDE inspection findings. The reliability of these examinations will then be validated by destructive analyses of the steam generator tubes. The program is expected to contribute to development of a model for steam generator inservice inspection sampling plans and inspection periods, as well as to improved regulatory guidelines for tube plugging

Lessons learned from tubes pulled from French steam generators

International Nuclear Information System (INIS)

Berge, Ph.; Boursier, J.M.; Dallery, D.; De Keroulas, F.; Rouillon, Y.

1998-01-01

Since 1981, the Chinon Hot Laboratory has completed more than 380 metallurgical examinations of pulled French steam generator tubes. Electricite de France decided to perform such investigations from the very outset of the French nuclear program, in order to contribute to nuclear power plant safety. The main reasons for withdrawing tubes are to evaluate the degradation, to validate non destructive examination (NDE) techniques, to gain a better understanding of cracking phenomena, and to ensure that the criteria on which plugging operations are based remain conservative. Considerable experience has been accumulated in the field of primary water stress corrosion cracking (PWSCC), OD (secondary) side corrosion, leak and burst tests, and various tube plugging techniques. This paper focuses on the PWSCC phenomenon and on the secondary side corrosion process, and in particular, attempts to correlate French data from pulled tubes with the results of fundamental R and D studies. Finally, within the framework of the Nuclear Power Plant Safety and Maintenance Policy, all these results are discussed in terms of optimization of the field inspection of tube bundles and plugging criteria. (author)

Successful placement of the Essure device after a failed procedure using the Adiana system for hysteroscopic sterilisation

Science.gov (United States)

Schuurman, Teska; Veersema, Sebastiaan

2011-01-01

This case report describes a successful hysteroscopic sterilisation using the Essure Permanent Birth Control device (Conceptus Inc., Mountain View, California, United States) after a failed procedure of the Adiana Permanent Contraception system (Hologic, Inc., Bedford, Maryland, United States). The delivery catheter of the Adiana system was able to be inserted into the left fallopian tube without difficulty and per manufacturer specifications. However, the position detection array was unable to sense four-quadrant tissue contact. The same issue occurred at the contralateral tube. Using the Essure system, the coils were able to be placed in both ostia easily and adequately. In patients in whom the Adiana system fails to occlude the fallopian tubes due to procedural, anatomic or device-related factors, the Essure procedure may be an efficient alternative. PMID:22689274

Modelling of fiberglass pipe destruction process

Directory of Open Access Journals (Sweden)

А. К. Николаев

2017-03-01

Full Text Available The article deals with important current issue of oil and gas industry of using tubes made of high-strength composite corrosion resistant materials. In order to improve operational safety of industrial pipes it is feasible to use composite fiberglass tubes. More than half of the accidents at oil and gas sites happen at oil gathering systems due to high corrosiveness of pumped fluid. To reduce number of accidents and improve environmental protection we need to solve the issue of industrial pipes durability. This problem could be solved by using composite materials from fiberglass, which have required physical and mechanical properties for oil pipes. The durability and strength can be monitored by a fiberglass winding method, number of layers in composite material and high corrosion-resistance properties of fiberglass. Usage of high-strength composite materials in oil production is economically feasible; fiberglass pipes production is cheaper than steel pipes. Fiberglass has small volume weight, which simplifies pipe transportation and installation. In order to identify the efficiency of using high-strength composite materials at oil production sites we conducted a research of their physical-mechanical properties and modelled fiber pipe destruction process.

Review of damages of nuclear power plants steam generator's tubes and way of detecting by using eddy current method

International Nuclear Information System (INIS)

Stanic, D.

1996-01-01

Steam generator tubing integrity is very important factor for reliable and safe operation of NPP. Several different types of tube degradation mechanisms were experienced in SG operation. To avoid possible tube rupture and primary-to-secondary leak, the EC examination of tubing should be performed. Different eddy current techniques may be used for detecting defects and theirs characterization. A comparison of data analysis results with pulled tube destructive metallography results can provide valuable insights in determining the capability of existing technology and provide guidance for procedure or technology improvements. (author)

Exergoeconomic optimization of coaxial tube evaporators for cooling of high pressure gaseous hydrogen during vehicle fuelling

DEFF Research Database (Denmark)

Jensen, Jonas Kjær; Rothuizen, Erasmus Damgaard; Markussen, Wiebke Brix

2014-01-01

Gaseous hydrogen as an automotive fuel is reaching the point of commercial introduction. Development of hydrogen fuelling stations considering an acceptable fuelling time by cooling the hydrogen to -40 C has started. This paper presents a design study of coaxial tube ammonia evaporators for three......-stage evaporator. The main contribution to the total cost was the cost associated with exergy destruction, the capital investment cost contributed with 5-14 %. The main contribution to the exergy destruction was found to be thermally driven. The pressure driven exergy destruction accounted for 3-9 %....

Exergoeconomic optimization of coaxial tube evaporators for cooling of high pressure gaseous hydrogen during vehicle fuelling

International Nuclear Information System (INIS)

Jensen, Jonas K.; Rothuizen, Erasmus D.; Markussen, Wiebke B.

2014-01-01

Highlights: • Three concepts of cooling hydrogen were identified. • A numerical heat transfer model of a coaxial-tube evaporator was built. • The cost of exergy destruction and capital investment cost was evaluated for a range of feasible solution. • The exergoeconomic optimum design for all three concepts was identified. • Cooling with a two-stage evaporator reduces total cost 45% compared to a one-stage evaporator. - Abstract: Gaseous hydrogen as an automotive fuel is reaching the point of commercial introduction. Development of hydrogen fuelling stations considering an acceptable fuelling time by cooling the hydrogen to −40 °C has started. This paper presents a design study of coaxial tube ammonia evaporators for three different concepts of hydrogen cooling, one one-stage and two two-stage processes. An exergoeconomic optimization is imposed to all three concepts to minimize the total cost. A numerical heat transfer model is developed in Engineer Equation Solver, using heat transfer and pressure drop correlations from the open literature. With this model the optimal choice of tube sizes and circuit numbers are found for all three concepts. The results show that cooling with a two-stage evaporator after the pressure reduction valve yields the lowest total cost, 45% lower than the highest, which is with a one-stage evaporator. The main contribution to the total cost was the cost associated with exergy destruction, the capital investment cost contributed with 5–14%. The main contribution to the exergy destruction was found to be thermally driven. The pressure driven exergy destruction accounted for 3–9%

Characterization of flaws in a tube bundle mock-up for reliability studies

International Nuclear Information System (INIS)

Kupperman, D.S.; Bakhtiari, S.

1997-01-01

As part of an assessment of in-service inspection of steam generator tubes, the authors will assemble a steam generator mock-up for round robin studies and use as a test bed in evaluating emerging technologies. Progress is reported on the characterization of flaws that will be part of the mock-up. Eddy current and ultrasonic techniques are being evaluated as a means to characterize the flaws in the mock-up tubes before final assembly. Twenty Inconel 600 tubes with laboratory-grown cracks, typical of those to be used in the mock-up, were provided by Pacific Northwest National Laboratory for laboratory testing. After the tubes were inspected with eddy current and ultrasonic techniques, they were destructively analyzed to establish the actual depths, lengths, and profiles of the cracks. The analysis of the results will allow the best techniques to be used for characterizing the flaws in the mock-up tubes

Characterization of flaws in a tube bundle mock-up for reliability studies

International Nuclear Information System (INIS)

Kupperman, D.S.; Bakhtiari, S.

1996-10-01

As part of an assessment of in-service inspection of steam generator tubes, the authors will assemble a steam generator mock-up for round robin studies and use as a test bed in evaluating emerging technologies. Progress is reported on the characterization of flaws that will be part of the mock-up. Eddy current and ultrasonic techniques are being evaluated as a means to characterize the flaws in the mock-up tubes before final assembly. Twenty Inconel 600 tubes with laboratory-grown cracks, typical of those to be used in the mock-up, were provided by Pacific Northwest National Laboratory for laboratory testing. After the tubes were inspected with eddy current and ultrasonic techniques, they were destructively analyzed to establish the actual depths, lengths, and profiles of the cracks. The analysis of the results will allow the best techniques to be used for characterizing the flaws in the mock-up tubes

Uncertainty analysis for probabilistic steam generators tube rupture in LBB applications

Energy Technology Data Exchange (ETDEWEB)

Durbec, V.; Pitner, P.; Pages, D. [Electricite de France, 78 - Chatou (France). Research and Development Div.; Riffard, T. [Electricite de France, 69 - Villeurbanne (France). Engineering and Construction Div.; Flesch, B. [Electricite de France, 92 - Paris la Defense (France). Generation and Transmission Div.

1997-10-01

Steam Generators (SG) of Pressurized Water Reactors have experienced world wide various types of tube degradations, mainly from stress corrosion cracking; because of this damage, primary-secondary leakage or tube rupture can occur. Safety against the risk of tube rupture is achieved through a combination of periodic in-service inspections (eddy current testing), surveillance of leaks during operation (leak before break concept) and tube plugging. In order to optimize the tube bundle SG maintenance, Electricite de France has developed a specific software named COMPROMIS. The model, based on probabilistic fracture mechanics makes it possible to quantify the influence of in service inspections and maintenance work on the risk of a SG Tube Rupture (SGTR), taking all significant parameters into account as random variables (initial defect size distribution, reliability of non-destructive examinations, crack initiation and propagation, critical sizes, leak before risk of break, etc...). This paper focuses on the leak rate calculation module and presents a sensitivity study of the influence of the leak before break on the conditional failure probability. (author) 8 refs.

Uncertainty analysis for probabilistic steam generators tube rupture in LBB applications

International Nuclear Information System (INIS)

Durbec, V.; Pitner, P.; Pages, D.; Riffard, T.; Flesch, B.

1997-10-01

Steam Generators (SG) of Pressurized Water Reactors have experienced world wide various types of tube degradations, mainly from stress corrosion cracking; because of this damage, primary-secondary leakage or tube rupture can occur. Safety against the risk of tube rupture is achieved through a combination of periodic in-service inspections (eddy current testing), surveillance of leaks during operation (leak before break concept) and tube plugging. In order to optimize the tube bundle SG maintenance, Electricite de France has developed a specific software named COMPROMIS. The model, based on probabilistic fracture mechanics makes it possible to quantify the influence of in service inspections and maintenance work on the risk of a SG Tube Rupture (SGTR), taking all significant parameters into account as random variables (initial defect size distribution, reliability of non-destructive examinations, crack initiation and propagation, critical sizes, leak before risk of break, etc...). This paper focuses on the leak rate calculation module and presents a sensitivity study of the influence of the leak before break on the conditional failure probability. (author)

Proposal for a Coordinated Research Project: Prediction of Axial and Radial Creep in Pressure Tubes

International Nuclear Information System (INIS)

Bozzano, Patricia B.

2013-01-01

Participation of Argentina: • hydrogen charge of 90 samples for hydrogen determination: IGF, HVEMS, DSC, Resistivity, DTA; • 17 samples for non destructive techniques; • 6 blisters in CANDU pressure tube sections for NDT evaluation

Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics.

Science.gov (United States)

Gross, Amy L; Kurman, Robert J; Vang, Russell; Shih, Ie-Ming; Visvanathan, Kala

2010-01-01

The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs) but our own findings (unpublished data) and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs).

Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics

Directory of Open Access Journals (Sweden)

Amy L. Gross

2010-01-01

Full Text Available The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC, particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. The finding of occult invasive and intraepithelial fallopian tube carcinomas in prophylactically removed specimens from asymptomatic high-risk BRCA 1/2-mutation carriers supports the notion of an origin for OSC in the fallopian tube. The intraepithelial carcinomas have been referred to as serous intraepithelial carcinomas (STICs but our own findings (unpublished data and recent reports have drawn attention to a spectrum of changes that fall short of STICs that we have designated serous tubal intraepithelial lesions (STILs.

The ectopic appendicolith from perforated appendicitis as a cause of tubo-ovarian abscess

International Nuclear Information System (INIS)

Vyas, Rajashree C.; Sides, Corey; Klein, Deborah J.; Reddy, Sireesha Y.; Santos, Mary C.

2008-01-01

Acute appendicitis is a common surgical cause of abdominal pain in the pediatric population. History and physical examination are atypical in up to a third of patients. Known potential complications of untreated or delayed management of acute appendicitis include appendiceal perforation, periappendiceal abscess formation, peritonitis, bowel obstruction and rarely septic thrombosis of mesenteric vessels. We report an unusual complication of perforated appendicitis. A tubo-ovarian abscess developed secondary to appendicolith migration into the right fallopian tube in a patient who had undergone interval laparoscopic appendectomy for perforated appendicitis. The retained appendicolith was visualized within the obstructed and dilated fallopian tube on contrast-enhanced CT. We discuss the CT imaging features of this unusual complication of perforated appendicitis. (orig.)

The ectopic appendicolith from perforated appendicitis as a cause of tubo-ovarian abscess

Energy Technology Data Exchange (ETDEWEB)

Vyas, Rajashree C.; Sides, Corey; Klein, Deborah J. [University of Rochester Medical Center, Rochester, NY (United States); Reddy, Sireesha Y. [University of Rochester, Obstetrics and Gynecology, Rochester, NY (United States); Santos, Mary C. [University of Rochester, Pediatric Surgery, Rochester, NY (United States)

2008-09-15

Acute appendicitis is a common surgical cause of abdominal pain in the pediatric population. History and physical examination are atypical in up to a third of patients. Known potential complications of untreated or delayed management of acute appendicitis include appendiceal perforation, periappendiceal abscess formation, peritonitis, bowel obstruction and rarely septic thrombosis of mesenteric vessels. We report an unusual complication of perforated appendicitis. A tubo-ovarian abscess developed secondary to appendicolith migration into the right fallopian tube in a patient who had undergone interval laparoscopic appendectomy for perforated appendicitis. The retained appendicolith was visualized within the obstructed and dilated fallopian tube on contrast-enhanced CT. We discuss the CT imaging features of this unusual complication of perforated appendicitis. (orig.)

Inlet effect induced ''upstream'' critical heat flux in smooth tubes

International Nuclear Information System (INIS)

Kitto, J.B. Jr.

1986-01-01

An unusual form of ''upstream'' critical heat flux (CHF) has been observed and directly linked to the inlet flow pattern during an experimental study of high pressure (17 - 20 MPa) water flowing through a vertical 38.1 mm ID smooth bore tube with uniform axial and nonuniform circumferential heating. These upstream CHF data were characterized by temperature excursions which initially occurred at a relatively fixed axial location in the middle of the test section while the outlet and inlet heated lengths experienced no change. A rifled tube inlet flow conditioner could be substituted for a smooth tube section to generate the desired swirling inlet flow pattern. The upstream CHF data were found to match data from a uniformly heated smooth bore tube when the comparison was made using the peak local heat flux. The mechanism proposed to account for the upstream CHF observations involves the destructive interference between the decaying swirl flow and the secondary circumferential liquid flow field resulting from the one-sided heating

Application of non-destructive liner thickness measurement technique for manufacturing and inspection process of zirconium lined cladding tube

International Nuclear Information System (INIS)

Nakazawa, Norio; Fukuda, Akihiro; Fujii, Noritsugu; Inoue, Koichi

1986-01-01

Recently, in order to meet the difference of electric power demand owing to electric power situation, large scale load following operation has become necessary. Therefore, the development of the cladding tubes which withstand power variation has been carried out, as the result, zirconium-lined zircaloy 2 cladding tubes have been developed. In order to reduce the sensitivity to stress corrosion cracking, these zirconium-lined cladding tubes require uniform liner thickness over the whole surface and whole length. Kobe Steel Ltd. developed the nondestructive liner thickness measuring technique based on ultrasonic flaw detection technique and eddy current flaw detection technique. These equipments were applied to the manufacturing and inspection processes of the zirconium-lined cladding tubes, and have demonstrated superiority in the control and assurance of the liner thickness of products. Zirconium-lined cladding tubes, the development of the measuring technique for guaranteeing the uniform liner thickness and the liner thickness control in the manufacturing and inspection processes are described. (Kako, I.)

Stress analysis of thermal sprayed coatings using a semi-destructive hole-drilling strain gauge method

International Nuclear Information System (INIS)

Dolhof, V.; Musil, J.; Cepera, M.; Zeman, J.

1995-01-01

Residual stress is an important parameter in coating technology since it often relates to the maximum coating thickness which can be deposited without spallation, and this applies to coatings produced by different thermal spray and thin film technologies. Indeed, the mechanisms by which residual stress is built up or locked into a coating depends markedly on the deposition process and coating structure (growth structure, phase composition) in the same way too. Methods for determining residual stresses in materials include both destructive and non-destructive methods. This contribution describes semi-destructive hole-drilling strain gauge method modified for measurement of residual stresses in thermal sprayed coatings. This method of stress analysis was used for determination of stress levels in thermal sprayed WC-17% Co coatings onto 13% Cr steel substrates. Results show that deposition conditions and final coating structure influence directly the residual stress level in the coatings. It is proved that semi-destructive hole-tube drilling measurement is effective reproducible method of coating stress analysis and good solution for optimization of deposition process

Evaluation of ECT reliability for axial ODSCC in steam generator tubes

International Nuclear Information System (INIS)

Lee, Jae Bong; Park, Jai Hak; Kim, Hong Deok; Chung, Han Sub

2010-01-01

The integrity of steam generator tubes is usually evaluated based on eddy current test (ECT) results. Because detection capacity of the ECT is not perfect, all of the physical flaws, which actually exist in steam generator tubes, cannot be detected by ECT inspection. Therefore it is very important to analyze ECT reliability in the integrity assessment of steam generators. The reliability of an ECT inspection system is divided into reliability of inspection technique and reliability of quality of analyst. And the reliability of ECT results is also divided into reliability of size and reliability of detection. The reliability of ECT sizing is often characterized as a linear regression model relating true flaw size data to measured flaw size data. The reliability of detection is characterized in terms of probability of detection (POD), which is expressed as a function of flaw size. In this paper the reliability of an ECT inspection system is analyzed quantitatively. POD of the ECT inspection system for axial outside diameter stress corrosion cracks (ODSCC) in steam generator tubes is evaluated. Using a log-logistic regression model, POD is evaluated from hit (detection) and miss (no detection) binary data obtained from destructive and non-destructive inspections of cracked tubes. Crack length and crack depth are considered as variables in multivariate log-logistic regression and their effects on detection capacity are assessed using two-dimensional POD (2-D POD) surface. The reliability of detection is also analyzed using POD for inspection technique (POD T ) and POD for analyst (POD A ).

Clinicopathologic study of serous tubal intraepithelial carcinoma with invasive carcinoma: is serous tubal intraepithelial carcinoma a reliable feature for determining the organ of origin?

Science.gov (United States)

Gao, Faye F; Bhargava, Rohit; Yang, Huaitao; Li, Zaibo; Zhao, Chengquan

2013-08-01

In the past several decades, the concept of serous ovarian carcinoma has been revised repeatedly. However, the exact pathogenesis remains controversial. The most popular current concept is origin from the epithelium of the fimbriated ends of the fallopian tubes. The objective of our study was to evaluate the characteristic clinical and morphologic features of serous tubal intraepithelial carcinoma (STIC) and associated invasive carcinomas. One hundred sixteen consecutive cases of STIC seen from 2007 to 2011 were included in this study. High-grade serous carcinoma (HGSC) with or without a mixed component was identified in 107 cases (92.2%), non-HGSC in 5 cases, and STICs without invasive carcinoma in 4 cases. Using conventional criteria, HGSCs were classified as fallopian tube in origin in 65 cases (60.7%), as ovarian in 30 (28.0%), as peritoneal in 9 (8.4%), and as endometrial in 3 (2.8%). Among the 107 cases with HGSCs, most STICs (86; 80%) were present unilaterally, whereas invasive tumors more commonly involved the ovaries bilaterally (79%; 84 cases). These findings support the hypothesis that STIC acts as a precursor lesion for most fallopian tube, ovarian, and peritoneal HGSCs, but not for endometrial HGSC. Copyright © 2013 Elsevier Inc. All rights reserved.

Non-destructive Engineering

International Nuclear Information System (INIS)

Ko, Jin Hyeon; Ryu, Taek In; Ko, Jun Bin; Hwang, Yong Hwa

2006-08-01

This book gives descriptions of non-destructive engineering on outline of non-destructive test, weld defects, radiographic inspection radiography, ultrasonic inspection, magnetic particle testing, liquid penetrant testing, eddy current inspection method, strain measurement, acoustic emission inspection method, other non-destructive testing like leakage inspection method, and non-destructive mechanics for fault analysis such as Griffiths creaking theory, and stress analysis of creaking.

Experience of steam generator tube examination in the hot laboratory of EDF: analysis of recent events concerning the secondary side

International Nuclear Information System (INIS)

Thebault, Y.; Bouvier, O. de; Boccanfuso, M.; Coquio, N.; Barbe, V.; Molinie, E.

2011-01-01

Until 2010, more than 60 steam generator (SG) tubes have been removed and analysed in the EDF hot laboratory of CEIDRE/Chinon. This article is particularly related to three recent events that lead to the extraction of several tubes dedicated to laboratory destructive examinations. The first event that constitutes a first occurrence on the EDF Park, concerns the detection of a circumferential crack on the external surface of a tube located at tube support plate elevation. After this observation, several tubes have been extracted from Bugey 3 and Fessenheim 2 nuclear power plants with steam generators equipped with 600 MA bundle. The other two events concern the consequences of chemical cleaning of the tube bundle steam generators. The examples chosen are from Cruas 4 et Chinon B2 units whose tubes were extracted following non destructive testing performed immediately after or at the completion of cycle following the chemical cleaning. In the case of Cruas 4, Eddy Current Testing (ET) were performed for requalification of steam Generators after chemical cleaning. They allowed the detection of an indication located at the bottom of tube for a large number of tubes; the ET signal was similar to that corresponding to 'deposit' corrosion. Moreover, inspections of Chinon-B2 SGs at the end of the operation cycle following the chemical cleaning, showed the presence of conductor deposits at the bottom of some tubes. The first part of this document presents the major results of laboratory examinations of the pulled tubes of Bugey 3 and Fessenheim 2 and their analysis. Hypothesis concerning damage mechanisms of the tubes are also proposed. The second part of the paper relates the results of the laboratory examinations of the pulled tubes of Cruas 4 and Chinon B 2 after chemical cleaning and their analysis. (authors)

Modelling of thermal behaviour of iron oxide layers on boiler tubes

Science.gov (United States)

Angelo, J. D.; Bennecer, A.; Kaczmarczyk, S.; Picton, P.

2016-05-01

Slender boiler tubes are subject to localised swelling when they are expose to excessive heat. The latter is due to the formation of an oxide layer, which acts as an insulation barrier. This excessive heat can lead to microstructural changes in the material that would reduce the mechanical strength and would eventually lead to critical and catastrophic failure. Detecting such creep damage remains a formidable challenge for boiler operators. It involves a costly process of shutting down the plant, performing electromagnetic and ultrasonic non-destructive inspection, repairing or replacing damaged tubes and finally restarting the plant to resume its service. This research explores through a model developed using a finite element computer simulation platform the thermal behaviour of slender tubes under constant temperature exceeding 723 °K. Our simulation results demonstrate that hematite layers up to 15 μm thickness inside the tubes do not act as insulation. They clearly show the process of long term overheating on the outside of boiler tubes which in turn leads to initiation of flaws.

Failure Analysis and Magnetic Evaluation of Tertiary Superheater Tube Used in Gas-Fired Boiler

Science.gov (United States)

Mohapatra, J. N.; Patil, Sujay; Sah, Rameshwar; Krishna, P. C.; Eswarappa, B.

2018-02-01

Failure analysis was carried out on a prematurely failed tertiary superheater tube used in gas-fired boiler. The analysis includes a comparative study of visual examination, chemical composition, hardness and microstructure at failed region, adjacent and far to failure as well as on fresh tube. The chemistry was found matching to the standard specification, whereas the hardness was low in failed tube compared to the fish mouth opening region and the fresh tube. Microscopic examination of failed sample revealed the presence of spheroidal carbides of Cr and Mo predominantly along the grain boundaries. The primary cause of failure is found to be localized heating. Magnetic hysteresis loop (MHL) measurements were carried out to correlate the magnetic parameters with microstructure and mechanical properties to establish a possible non-destructive evaluation (NDE) for health monitoring of the tubes. The coercivity of the MHL showed a very good correlation with microstructure and mechanical properties deterioration enabling a possible NDE technique for the health monitoring of the tubes.

The use of titanium for condenser tube bundles

International Nuclear Information System (INIS)

Dobrovitch, N.

2002-01-01

In a power plant, the condenser is a strategic heat exchanger with regards to the efficiency of the steam turbine and its reliability guarantees the performance and continuous operation of the plant. Until the early 1980's, copper alloys were routinely used in condenser tubes, thanks to their high heat transfer rates. Yet numerous problems arose from the use of this material, such as stress cracking corrosion, ammoniacal corrosion, fouling, erosion, dezincification, abrasion, erosion-corrosion,... and lately the problem of inadequateness of copper with nuclear steam generators (in nuclear power plant the abrasion problem of the copper alloy tubes created a deposit problem in the steam generator conducting to the replacement of all the condensers). The trend was then to consider new tube materials, such stainless steel and titanium, firstly for particular operating conditions and now for most of the projects, with several objectives, such as: 1) improve the reliability (titanium in particular can bring major improvements such as higher water velocities promoting better heat coefficients, excellent resistance to abrasion, erosion and corrosion thereby improving resistance to fouling; 2) find more cost-effective solutions. The first investment is higher but money is saved on maintenance costs and on time reliability of the material. Titanium tube manufacturing has greatly evolved for the last 20 years. Tubes are mostly welded tubes from ASTM SB 338 grade 1 made on a continuous manufacturing line. All manufacturing operations (welding, annealing, non-destructive testing) are fully automated to produce high quality tubes in large quantities. The most common way to attach tubes to a tubesheet is to roller expand them. (A.C.)

Infertility caused by tubal blockage: An ayurvedic appraisal

Science.gov (United States)

Shukla (Upadhyaya), Kamayani; Karunagoda, Kaumadi; Dei, L. P.

2010-01-01

Tubal blockage is one of the most important factors for female infertility. This condition is not described in Ayurvedic classics, as the fallopian tube itself is not mentioned directly there. The present study is an effort to understand the disease according to Ayurvedic principles. Correlating fallopian tubes with the Artavavaha (Artava-bija-vaha) Srotas, its block is compared with the Sanga Srotodushti of this Srotas. Charak's opinion that the diseases are innumerable and newly discovered ones should be understood in terms of Prakriti, Adhishthana, Linga, and Aayatana, is followed, to describe this disease. An effort has been made to evaluate the role of all the three Doshas in producing blockage, with classification of the disease done as per the Dasha Roganika. PMID:22131704

Infertility

Science.gov (United States)

... function of the ovaries, uterus and fallopian tubes. Primary ovarian insufficiency (early menopause), when the ovaries stop working and menstruation ends before age 40. Although the cause is often unknown, certain ...

Isolated torsion of fallopian tube. Radiological findings

International Nuclear Information System (INIS)

Tomas Fanjul, L.; Aldea Martinez, J.; Fernandez Matia, G.; Rodrigo Verguizas, J.; Fernandez Alvarez, G.; Galindo Vicente, M.C.

1993-01-01

Isolated tubal torsion is a very uncommon disorder that is rarely diagnosed preoperatively. We present a case and review the literature, which only provides ultrasonographic findings in 5 cases reported to date. 11 refs

A Molar Pregnancy within the Fallopian Tube

Directory of Open Access Journals (Sweden)

Laura Allen

2016-01-01

Full Text Available Background. Discussion of the incidence of molar pregnancy and ectopic pregnancy. Role of salpingostomy and special considerations for postoperative care. Case. The patient is a 29-year-old G7P4 who presented with vaginal bleeding in the first trimester and was initially thought to have a spontaneous abortion. Ultrasound was performed due to ongoing symptoms and an adnexal mass was noted. She underwent uncomplicated salpingostomy and was later found to have a partial molar ectopic pregnancy. Conclusion. This case illustrates the rare occurrence of a molar ectopic pregnancy. There was no indication of molar pregnancy preoperatively and this case highlights the importance of submitting and reviewing pathological specimens.

Are all pelvic (nonuterine) serous carcinomas of tubal origin?

Science.gov (United States)

Przybycin, Christopher G; Kurman, Robert J; Ronnett, Brigitte M; Shih, Ie-Ming; Vang, Russell

2010-10-01

It has been proposed that the presence of tubal intraepithelial carcinoma (TIC), in association with one-third to nearly half of pelvic serous carcinomas, is evidence of fallopian tube origin for high-grade serous carcinomas that would have been otherwise classified as primary ovarian or peritoneal. To address this hypothesis, we evaluated a series of 114 consecutive pelvic (nonuterine) gynecologic carcinomas at our institution (2006 to 2008) to determine the frequency of TIC in 52 cases in which all the resected fallopian tube tissue was examined microscopically. These 52 cases were classified as ovarian (n=37), peritoneal (n=8), or fallopian tube (n=7) in origin as per conventional criteria based on disease distribution. The presence of TIC and its location and relationship to invasive carcinoma in the fallopian tubes and ovaries were assessed. Among the 45 cases of ovarian/peritoneal origin, carcinoma subtypes included 41 high-grade serous, 1 endometrioid, 1 mucinous, 1 high-grade, not otherwise specified, and 1 malignant mesodermal mixed tumor. TIC was identified in 24 cases (59%) of high-grade serous carcinoma but not among any of the other subtypes; therefore, the term serous TIC (STIC) is a more specific appellation. STICs were located in the fimbriated end of the tube in 22 cases (92%) and in the ampulla in 2 (8%); they were unilateral in 21 (88%) and bilateral in 3 (13%). STICs in the absence of an associated invasive carcinoma in the same tube were detected in 7 cases (30%) and with invasive carcinoma in the same tube in 17 (71%). Unilateral STICs were associated with bilateral ovarian involvement in 15 cases and unilateral (ipsilateral) ovarian involvement in 5 (the remaining case with a unilateral STIC had a primary peritoneal tumor with no ovarian involvement); the bilateral STICs were all associated with bilateral ovarian involvement. Six of the 7 primary tubal tumors were high-grade serous carcinomas, and 4 of these 6 (67%) had STICs. Based on

The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice.

Science.gov (United States)

Kim, Jaeyeon; Coffey, Donna M; Ma, Lang; Matzuk, Martin M

2015-06-01

Although named "ovarian cancer," it has been unclear whether the cancer actually arises from the ovary, especially for high-grade serous carcinoma (HGSC), also known as high-grade serous ovarian cancer, the most common and deadliest ovarian cancer. In addition, the tumor suppressor p53 is the most frequently mutated gene in HGSC. However, whether mutated p53 can cause HGSC remains unknown. In this study, we bred a p53 mutation, p53(R172H), into conditional Dicer-Pten double-knockout (DKO) mice, a mouse model duplicating human HGSC, to generate triple-mutant (TKO) mice. Like DKO mice, these TKO mice develop metastatic HGSCs originating from the fallopian tube. Unlike DKO mice, however, even after fallopian tubes are removed in TKO mice, ovaries alone can develop metastatic HGSCs, indicating that a p53 mutation can drive HGSC arising from the ovary. To confirm this, we generated p53(R172H)-Pten double-mutant mice, one of the genetic control lines for TKO mice. As anticipated, these double-mutant mice also develop metastatic HGSCs from the ovary, verifying the HGSC-forming ability of ovaries with a p53 mutation. Our study therefore shows that ovaries harboring a p53 mutation, as well as fallopian tubes, can be a distinct tissue source of high-grade serous ovarian cancer in mice.

Eddy-current tests on operational evaluation of steam generator tubes in nuclear power plants

International Nuclear Information System (INIS)

Lopez, Luiz Antonio Negro Martin; Ting, Daniel Kao Sun

2000-01-01

This paper presents a worldwide research on the technical and economical impacts due to failure in tube bundles of nuclear power plant steam generators. An Eddy current non destructive test using Foucault currents for the inspection and failure detection on the tubes, and also the main type of defects. The paper also presents the signals generated by a Zetec MIZ-40 test equipment. This paper also presents a brief description of an automatic system for data analysis which is under development by using a fuzzy logic and artificial intelligence

Disease: H01554 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available ilder RJ ... TITLE ... Refractory fallopian tube carcinoma - current perspectives in pathogenesis and manage...ment. ... JOURNAL ... Int J Womens Health 6:149-57 (2014) DOI:10.2147/IJWH.S40889 ... PMID

Gonorrhea

Science.gov (United States)

... you are a sexually active man who is gay, bisexual, or who has sex with men, you ... are Formation of scar tissue that blocks fallopian tubes ; Ectopic pregnancy ( pregnancy outside the womb ); Infertility (inability ...

Tubal Ligation Reversal

Science.gov (United States)

... seal off the fallopian tubes, such as the Essure or Adiana systems, generally aren't reversible. Why ... electrocautery). Some types of sterilization, such as the Essure or Adiana systems, aren't considered reversible. Risks ...

Genetics Home Reference: primary ciliary dyskinesia

Science.gov (United States)

... primary ciliary dyskinesia also have year-round nasal congestion and a chronic cough. Chronic respiratory tract infections ... likely due to abnormal cilia in the fallopian tubes. Another feature of primary ciliary dyskinesia is recurrent ...

The PISC programme on defective steam generator tubes inspection. A status report

International Nuclear Information System (INIS)

Birac, C.; Comby, R.; Maciga, G.; Von Estorff, U.; Zanella, G.L.

1994-06-01

The general objective of the PISC Program (Programme for the Inspection of Steel Components) is to assess experimentally procedures and techniques in use for the in-service inspection of pressure components. The program is mainly a round robin test, the results of which are compared with real characteristics of the flaws obtained by destructive analysis. Materials tested are INCONEL 600 tubes, diameter 22.22 mm, wall thickness 1.27 mm. The technique applied is eddy current testing. The program of capability tests on loose tubes was started in 1990, the round robin tests ended in 1993. The preliminary results are presented. (R.P.). 8 refs., 9 figs., 4 tabs

Gestational Tubal Choriocarcinoma Presenting as a Pregnancy of Unknown Location following Ovarian Induction

Directory of Open Access Journals (Sweden)

Lawrence Hsu Lin

2018-01-01

Full Text Available The management of pregnancy of unknown location (PUL can be a challenging situation, since it can present as several different conditions. Here we describe a rare case of gestational choriocarcinoma arising in the fallopian tube after ovarian induction in an infertile patient. The patient received clomiphene for ovarian induction and had rising levels of human chorionic gonadotropin (hCG over nine months without sign of pregnancy. After referral to our center, the patient was diagnosed with a paraovarian tumor, which revealed a gestational choriocarcinoma arising in the fallopian tube; the final diagnosis was supported by pathological and cytogenomic analysis. Malignancies, such as gestational trophoblastic disease, should be in the differential diagnosis of PUL; the early recognition of these conditions is key for the proper treatment and favorable outcome.

Evaluation of the adhesive layer of blast tube using ultrasound

Energy Technology Data Exchange (ETDEWEB)

Park, Joon Soo; Song, Sung Jin; Kim, Young Hwan; Cho, Hyun [Dept. of Machanical Engineering, Sungkyunkwan University, Seoul (Korea, Republic of); Lim, Soo Yong; Yun, Nam Gyun [Agency for Defense Development, Daejeon (Korea, Republic of); Lee, Jeong Ki [Korea Inspection and Engineering Co., Ltd, Seoul (Korea, Republic of); Park, Young Joo [Hankuk Fiber Group, Milyang (Korea, Republic of)

2003-05-15

Ultrasonic testing method has been developed to evaluate adhesive layers in blast tube for the reliability of the rocket. The main objective of the present work was to find debonding and uncharged state between steel and FRP layers. We distinguish the debonding and uncharged state using the resonance method in the adhesive layers. It was found that the higher magnitude of ultrasound is reflected for the uncharged area in frequency domain, and shown good agreements with experimental results. The traditional ultrasonic pulse-echo method offers good implements for the distinction debonding area. The nondestructive testing results were compared with the micrography of destructive testing. As results, ultrasonic testing could be utilized for the evaluation of adhesive layer in the blast tube.

Implementation status of performance demonstration program for steam generator tubing analysts in Korea

International Nuclear Information System (INIS)

Cho, Chan Hee; Lee, Hee Jong; Yoo, Hyun Ju; Nam, Min Woo; Hong, Sung Yull

2013-01-01

Some essential components in nuclear power plants are periodically inspected using non destructive examinations, for example ultrasonic, eddy current and radiographic examinations, in order to determine their integrity. These components include nuclear power plant items such as vessels, containments, piping systems, pumps, valves, tubes and core support structure. Steam generator tubes have an important safety role because they constitute one of the primary barriers between the radioactive and non radioactive sides of the nuclear power plant. There is potential that if a tube bursts while a plant is operating, radioactivity from the primary coolant system could escape directly to the atmosphere. Therefore, in service inspections are critical in maintaining steam generator tube integrity. In general, the eddy current testing is widely used for the inspection of steam generator tubes due tube integrity. In general, the eddy current testing is widely used for the inspection of steam generator tubes due to its high inspection speed and flaw detectability on non magnetic tubes. However, it is not easy to analyze correctly eddy current signals because they are influenced by many factors. Therefore, the performance of eddy current data analysts for steam generator tubing should be demonstrated comprehensively. In Korea, the performance of steam generator tubing analysts has been demonstrated using the Qualified Data Analyst program. This paper describes the performance demonstration program for steam generator tubing analysts and its implementation results in Korea. The pass rate of domestic analysts for this program was 71.4%

Implementation status of performance demonstration program for steam generator tubing analysts in Korea

Energy Technology Data Exchange (ETDEWEB)

Cho, Chan Hee; Lee, Hee Jong; Yoo, Hyun Ju; Nam, Min Woo [KHNP Central Research Institute, Daejeon (Korea, Republic of); Hong, Sung Yull [Yeungnam Univ., Gyeongsan (Korea, Republic of)

2013-02-15

Some essential components in nuclear power plants are periodically inspected using non destructive examinations, for example ultrasonic, eddy current and radiographic examinations, in order to determine their integrity. These components include nuclear power plant items such as vessels, containments, piping systems, pumps, valves, tubes and core support structure. Steam generator tubes have an important safety role because they constitute one of the primary barriers between the radioactive and non radioactive sides of the nuclear power plant. There is potential that if a tube bursts while a plant is operating, radioactivity from the primary coolant system could escape directly to the atmosphere. Therefore, in service inspections are critical in maintaining steam generator tube integrity. In general, the eddy current testing is widely used for the inspection of steam generator tubes due tube integrity. In general, the eddy current testing is widely used for the inspection of steam generator tubes due to its high inspection speed and flaw detectability on non magnetic tubes. However, it is not easy to analyze correctly eddy current signals because they are influenced by many factors. Therefore, the performance of eddy current data analysts for steam generator tubing should be demonstrated comprehensively. In Korea, the performance of steam generator tubing analysts has been demonstrated using the Qualified Data Analyst program. This paper describes the performance demonstration program for steam generator tubing analysts and its implementation results in Korea. The pass rate of domestic analysts for this program was 71.4%.

Peritonitis due to genital tuberculosis

DEFF Research Database (Denmark)

Svendsen, J H; Mikkelsen, A L; Siemssen, O J

1985-01-01

A case of genital tuberculosis is presented. The diagnosis was made by laparotomy and histological examination of biopsies from peritoneum and the Fallopian tube. The literature is reviewed and the diagnostic approach and treatment discussed....

Laparoscopic Filshie clip sterilization and selective use of the methylene blue dye test.

Science.gov (United States)

Karoshi, Mahantesh; Yoong, Wai

2004-01-01

In laparoscopic Filshie clip sterilization, difficulties may arise in identifying the length of the fallopian tube, with the possibility of failure of sterilization. This article describes a novel intraoperative method of demonstrating adequate tubal closure.

Estimation of residual life of boiler tubes using steamside oxide scale thickness

International Nuclear Information System (INIS)

Vikrant, K.S.N.; Ramareddy, G.V.; Pavan, A.H.V.; Singh, Kulvir

2013-01-01

In thermal power plants, remaining-life-estimation of boiler tubes is required at regular intervals for a safer and a better functionality of boilers. In this paper, a new method is proposed for the residual life estimation of service exposed boiler tubes using Non-Destructive Ultrasonic Oxide scale thickness measurements, average metal temperature and creep master curve. While steady state conduction heat transfer equations are solved to calculate the average metal temperature, creep master curve is generated from short term stress rupture data of rupture life less than 5000 h on a virgin material. In the present study, the residual life of T22 (2.25Cr-1Mo) service exposed Platen Superheater tube is estimated using two master creep curves, i.e. Larson-Miller Parametric (LMP) method of standard ASME T22 creep data and Wilshire approach of short term stress rupture data of T22. As the residual life is calculated from fundamental conduction heat transfer theory and creep rupture data, the proposed method can be applied for different grades of boiler materials. -- Highlights: ► Residual life is calculated from non-destructive oxide scale thickness, creep master curve and average metal temperature. ► A new method is proposed for calculating residual life using above parameters and from conduction heat transfer principles. ► The method can be applied to different boiler grades for estimating residual life and hence the method is generic

Nonconventional concrete hollow blocks evaluation by destructive and non-destructive testing

Directory of Open Access Journals (Sweden)

M.S. Rodrigues

Full Text Available The aim of this study was to evaluate cementitious matrices properties by partial replacement of Portland cement by silica fume (SF or by rice husk ash (RHA, and their application in nonbearing hollow blocks, tested by destructive and non-destructive methods. The following mixtures were produced: reference (100% of Portland cement and Portland cement replacement (10% by mass with SF or RHA. The non-destructive testing showed that the highest values of UPV were obtained for SF-based blocks and RHA-based blocks. The destructive test showed better results for SF-based blocks, but there was no statistical difference between the RHA-based and control ones.

Multidetector computed tomography virtual hysterosalpingography in the investigation of the uterus and fallopian tubes

International Nuclear Information System (INIS)

Carrascosa, Patricia; Baronio, Mariano; Capunay, Carlos; Lopez, Elba Martin; Vallejos, Javier; Borghi, Mario; Sueldo, Carlos; Papier, Sergio

2008-01-01

Objective: To compare the efficacy of multidetector CT virtual hysterosalpingography (MDCT-VH) with conventional X-ray hysterosalpingography (HSG) in the evaluation of patients with diagnosis of infertility. Methods: Sixty patients with diagnosis of infertility scheduled to perform a HSG, were evaluated with 16-row (n = 50) and 64-row (n = 10) MDCT-VH. In 35 patients the examination was performed without a tenaculum. The HSGs were carried out using standard technique. The HSG and MDCT-VH findings were compared. The duration for both examinations and patient discomfort were documented. The sensitivity and specificity of MDCT-VH for the detection of uterine pathology and tubal obstruction were calculated using the exact binomial method. Agreement between the two methods was assessed by the Cohen's kappa method (k). Results: The mean duration for MDCT-VH (16 and 64-rows) was 5 ± 3 min, whereas for HSG was 28 ± 3. The MDCT-VH without a tenaculum was the procedure with less patient discomfort. Sensitivity, specificity and inter-method agreement for the detection of uterine pathology were 100%, 92% and k = 0.92 for 16-row MDCT-VH and 100%, 100% and k = 1 for 64-row MDCT-VH, respectively. Sensitivity and specificity for detection of tubal obstruction were 80% and 80% for 16-row MDCT-VH and 100% and 100% for 64-row MDCT-VH, respectively; inter-method agreement for the visualization of the tubes was k = 0.54 for 16-row MDCT-VH and k = 1 for 64-row MDCT-VH. Conclusion: This study demonstrated the feasibility of evaluating the female reproductive system by MDCT-VH. 64-Row MDCT-VH could be an alternative diagnostic technique in the infertility workup algorithm. A larger study is in progress to validate these encouraging results

Multidetector computed tomography virtual hysterosalpingography in the investigation of the uterus and fallopian tubes

Energy Technology Data Exchange (ETDEWEB)

Carrascosa, Patricia [Diagnostico Maipu, Av. Maipu 1668, Vicente Lopez B1602ABQ, Buenos Aires (Argentina)], E-mail: patriciacarrascosa@diagnosticomaipu.com.ar; Baronio, Mariano [CEGYR, Viamonte 1438, Capital Federal C1055ABB (Argentina); Capunay, Carlos; Lopez, Elba Martin; Vallejos, Javier [Diagnostico Maipu, Av. Maipu 1668, Vicente Lopez B1602ABQ, Buenos Aires (Argentina); Borghi, Mario; Sueldo, Carlos; Papier, Sergio [CEGYR, Viamonte 1438, Capital Federal C1055ABB (Argentina)

2008-09-15

Objective: To compare the efficacy of multidetector CT virtual hysterosalpingography (MDCT-VH) with conventional X-ray hysterosalpingography (HSG) in the evaluation of patients with diagnosis of infertility. Methods: Sixty patients with diagnosis of infertility scheduled to perform a HSG, were evaluated with 16-row (n = 50) and 64-row (n = 10) MDCT-VH. In 35 patients the examination was performed without a tenaculum. The HSGs were carried out using standard technique. The HSG and MDCT-VH findings were compared. The duration for both examinations and patient discomfort were documented. The sensitivity and specificity of MDCT-VH for the detection of uterine pathology and tubal obstruction were calculated using the exact binomial method. Agreement between the two methods was assessed by the Cohen's kappa method (k). Results: The mean duration for MDCT-VH (16 and 64-rows) was 5 {+-} 3 min, whereas for HSG was 28 {+-} 3. The MDCT-VH without a tenaculum was the procedure with less patient discomfort. Sensitivity, specificity and inter-method agreement for the detection of uterine pathology were 100%, 92% and k = 0.92 for 16-row MDCT-VH and 100%, 100% and k = 1 for 64-row MDCT-VH, respectively. Sensitivity and specificity for detection of tubal obstruction were 80% and 80% for 16-row MDCT-VH and 100% and 100% for 64-row MDCT-VH, respectively; inter-method agreement for the visualization of the tubes was k = 0.54 for 16-row MDCT-VH and k = 1 for 64-row MDCT-VH. Conclusion: This study demonstrated the feasibility of evaluating the female reproductive system by MDCT-VH. 64-Row MDCT-VH could be an alternative diagnostic technique in the infertility workup algorithm. A larger study is in progress to validate these encouraging results.

Complementary Methods for the Characterization of Corrosion Products on a Plant-Exposed Superheater Tube

DEFF Research Database (Denmark)

Okoro, Sunday Chukwudi; Nießen, Frank; Villa, Matteo

2017-01-01

In this work, complex corrosion products on a superheater tube exposed to biomass firing were characterized by the complementary use of energy-dispersive synchrotron diffraction, electron microscopy, and energy-dispersive X-ray spectroscopy. Non-destructive synchrotron diffraction in transmission......-rich austenite phase to selective removal of Fe and Cr from the alloy, via a KCl-induced corrosion mechanism. Compositional variations were related to diffraction results and revealed a qualitative influence of the spinel cation concentration on the observed diffraction lines.......In this work, complex corrosion products on a superheater tube exposed to biomass firing were characterized by the complementary use of energy-dispersive synchrotron diffraction, electron microscopy, and energy-dispersive X-ray spectroscopy. Non-destructive synchrotron diffraction in transmission...... geometry measuring with a small gauge volume from the sample surface through the corrosion product allowed depth-resolved phase identification and revealed the presence of (Fe,Cr)2O3 and FeCr2O4. This was supplemented by microstructural and elemental analysis correlating the additional presence of a Ni...

Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls.

NARCIS (Netherlands)

Mingels, M.J.J.M.; Roelofsen, T.; Laak, J.A.W.M. van der; Hullu, J.A. de; Ham, M.A.P.C. van; Massuger, L.F.A.G.; Bulten, J.; Bol, M.

2012-01-01

OBJECTIVE: A precursor lesion for ovarian carcinoma, tubal intraepithelial carcinoma (TIC), has been identified in BRCA-mutation carriers undergoing prophylactic bilateral salpingo-oophorectomy (pBSO). Other lesions were also identified in fallopian tubes, but different terminology, interpretation,

Hysterosalpingography

Medline Plus

Full Text Available ... any scarring within the uterine or peritoneal (abdominal) cavity . The procedure can be used to investigate repeated ... contrast material then begins to fill the uterine cavity , fallopian tubes and peritoneal cavity through the catheter ...

Hysterosalpingography

Medline Plus

Full Text Available ... Hysterosalpingography, also called uterosalpingography, is an x-ray examination of a woman's uterus and fallopian tubes that ... look like? The equipment typically used for this examination consists of a radiographic table, one or two ...

Hysterosalpingography

Medline Plus

Full Text Available ... of tumor masses, adhesions and uterine fibroids. Hysterosalpingography can occasionally open blocked fallopian tubes to allow the ... the uterine or peritoneal (abdominal) cavity . The procedure can be used to investigate repeated miscarriages that result ...

Hysterosalpingography

Medline Plus

Full Text Available ... used to investigate repeated miscarriages that result from congenital or acquired abnormalities of the uterus and to ... of the fallopian tubes following a sterilization or disease-related blockage top of page How should I ...

“Horrendoplasty” – A case of total perineal destruction by agricultural implement

Directory of Open Access Journals (Sweden)

Pedro Simoes de Oliveira

2017-01-01

Full Text Available Although posterior urethral injury occurs almost always in association with pelvic fracture, it may result from severe trauma to the perineum with its associated potential lethality and severe morbidity. Early primary endoscopic realignment over a urethral catheter can be attempted, although an immediate suprapubic tube placement remains the standard of care. Definitive treatment consists of elective open posterior anastomotic urethroplasty through a perineal approach. The authors present a 53-year-old man who sustained total, massive perineal destruction resulting from work accident with an agricultural implement. Immediate suprapubic tube placement was performed followed by delayed elective transperineal anastomotic posterior urethroplasty. A major multidisciplinary approach was necessary in the management strategy, including orthopedic, general, plastic, vascular surgeries, and reconstructive urology teams. At a later stage, with the patient stabilized and recovered from major, life-threatening lesions dealt with by a multidisciplinary team, urethral reconstruction can be undertaken with ultimate good functional outcomes.

Application of probabilistic fracture mechanics to estimate the risk of rupture of PWR steam generator tubes

International Nuclear Information System (INIS)

Pitner, P.; Riffard, T.; Granger, B.

1992-01-01

This paper describes the COMPROMIS code developed by Electricite de France (EDF) to optimize the tube bundle maintenance of steam generators. The model, based on probabilistic fracture mechanics, makes it possible to quantify the influence of in-service inspections and maintenance work on the risk of an SG tube rupture, taking all significant parameters into account as random variables (initial defect size distribution, reliability of non-destructive detection and sizing, crack initiation and propagation, critical sizes, leak before risk of break, etc.). (authors). 5 refs., 8 figs., 3 tabs

Evaluation of the adhesive layer of blast tube by using ultrasound

Energy Technology Data Exchange (ETDEWEB)

Park, Joon Soo; Song, Sung Jin; Kim, Young H.; Cho, Hyun [Sungkyunkwan University, Seoul (Korea, Republic of); Lim, Soo Yong; Yun, Nam Gyun [Agency Defence Development, Daejeon (Korea, Republic of); Lee, Jeong Ki [Korea Inspection and Engineering Co., LTD, Daejeon (Korea, Republic of); Park, Young Joo [Hankuk Fiber Co., LTD, Milyang (Korea, Republic of)

2003-07-01

Ultrasonic testing method has been developed to evaluated adhesive layers in blast tube for the reliability of the rocket. The main objective of the present work was to find debonding and uncharged state between steel and FRP layers. We distinguish the debonding and uncharged state using the resonance method in the adhesive layers. It was found that the higher magnitude of ultrasound is reflected for the uncharged area in frequency domain, and shown good agreements with experimental results. The traditional ultrasonic pulse-echo method offers good implements for the distinction debonding area. The nondestructive testing results were compared with the micrography of destructive testing. As results, ultrasonic testing could be utilized for the evaluation of adhesive layer in the blast tube.

Gastrostomy Tube (G-Tube)

Science.gov (United States)

... any of these problems: a dislodged tube a blocked or clogged tube any signs of infection (including redness, swelling, or warmth at the tube site; discharge that's yellow, green, or foul-smelling; fever) excessive bleeding or drainage from the tube site severe abdominal pain lasting ...

Ultrasonic measurements for in-service assessment of wrought Inconel 625 cracker tubes of heavy water plants

International Nuclear Information System (INIS)

Kumar, Anish; Rajkumar, K.V.; Jayakumar, T.; Raj, Baldev; Mishra, B.

2006-01-01

The degradation in mechanical properties of Inconel 625 ammonia cracker tubes occurs during the service for long duration in heavy water plants. The present study brings out the possibility of using Poisson's ratio (derived from measurement of time of flight of ultrasonic waves) in combination with hardness measurements, as an effective non-destructive tool for assessment of in-service degradation of Inconel 625 cracker tubes and qualification of re-solution annealing heat treatment for their rejuvenation. Further, the study also indicates the feasibility of extending the life of some of the tubes beyond the presently followed 120 000 h, before they are taken up for re-solution annealing, without affecting their serviceability. However, further studies are required to identify quantitative criterion for Poisson's ratio and hardness values, for deciding on the basis for removal of the tubes for rejuvenation

Advanced Ultrasupercritical (AUSC) Tube Membrane Panel Development

Energy Technology Data Exchange (ETDEWEB)

Pschirer, James [Alstom Power Inc., Windsor, CT (United States); Burgess, Joshua [Alstom Power Inc., Windsor, CT (United States); Schrecengost, Robert [Alstom Power Inc., Windsor, CT (United States)

2017-08-16

Alstom Power Inc., a wholly owned subsidiary of the General Electric Company (GE), has completed the project “Advanced Ultrasupercritical (AUSC) Tube Membrane Panel Development” under U.S. Department of Energy (DOE) Award Number DE-FE0024076. This project was part of DOE’s Novel Crosscutting Research and Development to Support Advanced Energy Systems program. AUSC Tube Membrane Panel Development was a two and one half year project to develop and verify the manufacturability and serviceability of welded tube membrane panels made from high performance materials suitable for the AUSC steam cycles, defined as high pressure steam turbine inlet conditions of 700-760°C (1292-1400°F) and 24.5-35MPa (3500-5000psi). The difficulty of this challenge lies in the fact that the membrane-welded construction imposes demands on the materials that are unlike any that exist in other parts of the boiler. Tube membrane panels have been designed, fabricated, and installed in boilers for over 50 years with relatively favorable experience when fabricated from carbon and Cr-Mo low alloy steels. The AUSC steam cycle requires membrane tube panels fabricated from materials that have not been used in a weldment with metal temperatures in the range of 582-610°C (1080-1130°F). Fabrication materials chosen for the tubing were Grade 92 and HR6W. Grade 92 is a creep strength enhanced ferritic Cr-Mo alloy and HR6W is a high nickel alloy. Once the materials were chosen, GE performed the engineering design of the panels, prepared shop manufacturing drawings, and developed manufacturing and inspection plans. After the materials were purchased, GE manufactured and inspected the tube membrane panels, determined if post fabrication heat treatment of the tube membrane panels was needed, performed pre- and post-weld heat treatment on the Grade 92 panels, conducted final nondestructive inspection of any heat treated tube membrane panels, conducted destructive inspection of the completed tube

PROSPECTS OF ESTABLISHING EARTHQUAKE RESISTANT BUILDINGS FROM TUBE CONCRETE CONSTRUCTIONS

Directory of Open Access Journals (Sweden)

Abdujafar I. Akaev

2017-01-01

Full Text Available Abstract. Objectives The aim of the research is to find optimal design solutions for the erection of buildings that will ensure their reliability and durability, compliance with environmental requirements, fire resistance and earthquake resistance. In this regard, the task is to determine the advantages and prospects of erecting earthquake resistant buildings from tube concrete constructions, since they are distinct in constructive, technological and economic efficiency when are used as vertical load-bearing struts of high-rise buildings. Method The technique for calculating the strength of normal sections of eccentrically-compressed tube concrete elements uses a nonlinear deformation model, taking into account the joint operation of the steel shell and the concrete core under the conditions of triaxial compression. Results In the article the review of the newest world experience of using tube concrete as vertical load-bearing structures for public facilities from the standpoint of earthquake resistant construction is given. The international practices of public facility construction ranging in height from 100 to 600 m with the use of tube concrete technology, including regions with dangerous natural and man-made conditions, have been studied. The structural, operational and technological advantages and disadvantages of tube concrete technology are analysed. Methods for calculating the strength of concrete tube elements in the case of central compression are considered: according to the so-called deformation theory, the state of total destruction of both concrete and tube fluidity attained at maximum pressure are indicated by the beginning of "tube flow on the longitudinal axis". The advantages and disadvantages of both methods are shown. Factors constraining the introduction and wider application of tube concrete constructions in Russia are considered. Conclusion While the advantages of concrete tube constructions in their extensive

Hysterosalpingography

Medline Plus

Full Text Available ... uterus and fallopian tubes are filled with a water-soluble contrast material and the radiologist is able ... more information about pregnancy and x-rays. A Word About Minimizing Radiation Exposure Special ... About Us | Contact Us | FAQ | ...

Case report

African Journals Online (AJOL)

raoul

2011-01-19

Jan 19, 2011 ... After ascertaining that bleeding had ceased, the fallopian tube that had not been removed ... In one Indian study, it caused 9.3% of maternal deaths [2]. ... pain, cessation of uterine contractions, bleeding and shock is quite.

Ovarian Cancer Stage II

Science.gov (United States)

... peritoneal cancer; the first panel (stage IIA) shows cancer inside both ovaries that has spread to the uterus and fallopian tube. The second panel (stage IIB) shows cancer inside both ovaries that has spread to the colon. The third ...

Hysterosalpingography

Medline Plus

Full Text Available ... of a woman who is having difficulty becoming pregnant. It’s also used to investigate miscarriages resulting from ... fallopian tubes to allow the patient to become pregnant afterwards. Tell your doctor if there’s a possibility ...

Spontaneous transformation of murine oviductal epithelial cells: A model system to investigate the onset of fallopian-derived tumors

Directory of Open Access Journals (Sweden)

MIchael P. Endsley

2015-07-01

Full Text Available High-grade serous carcinoma (HGSC is the most lethal ovarian cancer histotype. The fallopian tube secretory epithelial cells (FTSECs are a proposed progenitor cell type. Genetically altered FTSECs form tumors in mice; however, a spontaneous HGSC model has not been described. Apart from a subpopulation of genetically predisposed women, most women develop ovarian cancer spontaneously, which is associated with aging and lifetime ovulations. A murine oviductal cell line (MOELOW was developed and continuously passaged in culture to mimic cellular aging (MOEHIGH. The MOEHIGH cellular model exhibited a loss of acetylated tubulin consistent with an outgrowth of secretory epithelial cells in culture. MOEHIGH cells proliferated significantly faster than MOELOW, and the MOEHIGH cells produced more 2D foci and 3D soft agar colonies as compared to MOELOW. MOEHIGH were xenografted into athymic female nude mice both in the subcutaneous and the intraperiteonal compartments. Only the subcutaneous grafts formed tumors that were negative for cytokeratin, but positive for oviductal markers such as oviductal glycoprotein 1 and Pax8. These tumors were considered to be poorly differentiated carcinoma. The differential molecular profiles between MOEHIGH and MOELOW were determined using RNA-Seq and confirmed by protein expression to uncover pathways important in transformation, like the p53 pathway, the FOXM1 pathway, WNT signaling, and splicing. MOEHIGH had enhanced protein expression of c-myc, Cyclin E, p53 and FOXM1 with reduced expression of p21. MOEHIGH were also less sensitive to cisplatin and DMBA, which induce lesions typically repaired by base-excision repair. A model of spontaneous tumorogenesis was generated starting with normal oviductal cells. Their transition to cancer involved alterations in pathways associated with high-grade serous cancer in humans.

Current Status on the Development of a Double Wall Tube Steam Generator

Energy Technology Data Exchange (ETDEWEB)

Nam, Ho Yun; Choi, Byoung Hae; Kim, Jong Man; Kim, Byung Ho

2007-12-15

A fast reactor, which uses sodium as a coolant, has a lot of merits as a next generation nuclear reactor. However, the possibility of a sodium-water reaction occurrence hinders the commercialization of this reactor. As one way to improve the reliability of a steam generator, a double-wall tube steam generator is being developed in GEN-4 program. In this report, the current state of the technical developments for a double-wall tube steam generator are reviewed and a future plan for the development of a double-wall tube steam generator is established. The current focuses of this research are an improvement of the heat transfer capability for a double-wall tube and the development of a proper leak detection method for the failure of a double-wall tube during a reactor operation. The ideal goal is an on-line leak detection of a double wall tube to prevent the sodium-water reaction. However, such a method is not developed as yet. An alternative method is being used to improve the reliability of a steam generator by performing a non-destructive test of a double wall tube during the refueling period of a reactor. In this method a straight double wall tube is employed to perform this test easily, but has a difficulty regarding an absorption of a thermal expansion of the used materials. If an on-line leak detection method is developed, the demerits of a straight double-wall tube are avoided by using a helical type double-wall tube, and the probability of a sodium-water reaction can be reduced to a level less than the design-based accident.

The utilization of VUJE specialists non-destructive testing qualification at international cooperation with company TECNATOM

International Nuclear Information System (INIS)

Kuna, M.

2006-01-01

The utilization of VUJE specialists non-destructive testing qualification at cooperation with company TECNATOM. The obtain of QDA qualification for ET examination for possibility of qualified evaluation in the foreign NPP (USA, Brazil). The acquired practical experiences by evaluation of ET data from NPP Angra Brazil and Waltz Mill USA. The obtain of SNT-TC-1A and EPRI qualification for the UT evaluation of penetration tube welds measurements. The practical experience during the measurement on NPP Shearon Harris (Author)

9 CFR 51.6 - Destruction of animals; time limit for destruction of animals.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Destruction of animals; time limit for destruction of animals. 51.6 Section 51.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION... ANIMALS DESTROYED BECAUSE OF BRUCELLOSIS Indemnity for Cattle, Bison, and Swine § 51.6 Destruction of...

Root cause analysis of SG tube leakage at Fessenheim unit 2 in 2008

International Nuclear Information System (INIS)

Berger, J.; Deotto, G.; Mathon, C.; Madurel, A.; Pitner, P.; Gay, N.; Guivarch, M.

2015-01-01

In February 2008, a primary-to-secondary leak caused an unscheduled shutdown at Fessenheim Unit 2 NPP. A circumferential crack was observed just above the top support plate of Row 12 Column 62 U-bend tube on Steam Generator (SG) number 3, which has been attributed to high cycle fatigue. This tube was pulled out in 2011, just before the SG replacement at the third decenal outage, in order to perform exhaustive metallurgical investigations. The destructive examinations revealed that the circumferential crack (70 degrees of extension) was due to high cycle fatigue, with several external initiation areas associated with the presence of small piles of Intergranular Attack (IGA) (600 MA tube) and with very low stress intensity factors ΔK (close to the non-propagating threshold region). This paper complements the metallurgical investigations by carrying out numerical analyses (thermal-hydraulic computation, fluid-elastic instability evaluation, tube vibratory response analysis and fatigue evaluation). The first objective of the study is to attempt to clarify the effect of IGA and the role of several competing factors that could be involved in the tube vibration induced fatigue failure. From these results, a root cause analysis of the R12C62 tube fatigue failure is then provided. It appears that a combination of various factors led to the failure of the tube

Persistence of Müllerian derivatives and intestinal lymphangiectasis in two newborn brothers: confirmation of the Urioste syndrome

NARCIS (Netherlands)

Bellini, C.; Bonioli, E.; Josso, N.; Belville, C.; Mazzella, M.; Costabel, S.; Sementa, A. R.; Marino, C. E.; Tomà, P.; Hennekam, R. C.; Serra, G.

2001-01-01

We describe two newborn brothers with a pattern of malformation characterized by the persistence of Müllerian duct derivatives, intestinal lymphangiectasia, hypertrophied alveolar ridges, and early death. Postmortem examination showed the presence of a rudimentary uterus, fallopian tubes, the upper

Magnetic resonance imaging of the uterus after endometrial resection

International Nuclear Information System (INIS)

Turnbull, L.; Jumaa, A.; Dhawan, S.; Horsman, A.; Killick, S.

1998-01-01

The majority of amenorrhoeic and all menstruating women have residual endometrium after endometrial resection. The lack of communication of islands of residual endometrium with the uterine cavity results in haematometra formation, fallopian tube dilatation and possibly free intraperitoneal fluid. (N.C.)

Magnetic resonance imaging of the uterus after endometrial resection

Energy Technology Data Exchange (ETDEWEB)

Turnbull, L.; Jumaa, A.; Dhawan, S.; Horsman, A.; Killick, S

1998-02-01

The majority of amenorrhoeic and all menstruating women have residual endometrium after endometrial resection. The lack of communication of islands of residual endometrium with the uterine cavity results in haematometra formation, fallopian tube dilatation and possibly free intraperitoneal fluid. (N.C.)

The use of enzyme-linked immunosorbent assay for detection of Mycoplasma hominis antibodies in infertile women serum samples

DEFF Research Database (Denmark)

Baczynska, Agata; Friis Svenstrup, Helle; Fedder, Jens

2005-01-01

BACKGROUND: Besides Chlamydiae trachomatis and Mycoplasma genitalium, Mycoplasma hominis may also cause infertility due to damage of the Fallopian tubes. Therefore serum samples from infertile women were analyzed for antibodies to M. hominis. METHODS: Sera from 304 infertile women were investigat...

Essure

Science.gov (United States)

Essure Overview The Essure system is a type of permanent birth control for women. It cannot be reversed. This type of female sterilization ... opening to the fallopian tubes and place the Essure system coils into them. It takes about three ...

Hysterosalpingography

Medline Plus

Full Text Available ... uterus and fallopian tubes are filled with a water-soluble contrast material and the radiologist is able ... more information about pregnancy and x-rays. A Word About Minimizing Radiation Exposure Special care ... About Us | Contact Us | FAQ | ...

Busbar arcs at large fusion magnets: Conductor to feeder tube arcing model experiments with the LONGARC device

Energy Technology Data Exchange (ETDEWEB)

Klimenko, Dmitry, E-mail: dmitry.klimenko@kit.edu; Pasler, Volker

2014-10-15

Highlights: •The LONGARC device was successfully implemented for busbar to feeder tubes arcing model experiments. •Arcing at an ITER busbar inside its feeder tube was simulated in scaled model experiments. •The narrower half tubes imply a slight increase of the arc propagation speed in compare to full tube experiments. •All simulated half tubes experiments show severe damage indicating that the ITER inner feeder tube will not withstand a busbar arc. -- Abstract: Electric arcs moving along the power cables (the so-called busbars) of the toroidal field (TF) coils of ITER may reach and penetrate the cryostat wall. Model experiments with the new LONGARC device continue the VACARC (VACuum ARC) experiments that were initiated to investigate the propagation and destruction mechanisms of busbar arcs in small scale [1]. The experiments are intended to support the development and validation of a numerical model. LONGARC overcomes the space limitations inside VACARC and allows also for advanced 1:3 (vs. ITER full scale) model setups. The LONGARC device and first results are presented below.

Destructiveness in Political Discourse

Directory of Open Access Journals (Sweden)

Яна Александровна Волкова

2016-12-01

Full Text Available Destructiveness is among the fundamental discourse categories that play a significant role in the organization of communicative interaction and define the pragmatics of discourse; its study helps to understand some mechanisms and principles of communication, identify strategies and tactics used by a destructive communicative personality. The relevance of this study is determined by the increasing aggressiveness in various types of discourse, and, accordingly, by the need to extend the knowledge of destructive behavior of a communicative personality. The study is based on the theory of discourse-analysis and theory of destructiveness (Z. Harris, T. van Dijk, A. Buss, E. Fromm, D. Ponton, K. Hacker, R. Wodak. N. Arutyunova, V. Karasik, M. Makarov, E. Sheigal et al. Developing the theory of destructiveness and relying on Erich Fromm’s research (1973, we specify the concept of “destructiveness” in relation to the political discourse and compare it with the related concept of aggressiveness. The paper analyses the category of destructiveness in modern US political discourse, using excerpts from the speeches of the candidates for presidency of 2016. Particular attention is paid to the dominant destructive intention - to harm the reputation of the opponent and reduce his political chances, as well as to the functions of verbal aggression: on the one hand - to discredit the opponent, bring accusations, on the other hand - to poison the audience mind against him/her and arouse the feeling of danger posed by a political opponent. The analysis of verbal and nonverbal means of destructiveness in the US political discourse is carried out. The article concludes that abusive remarks of politicians do not result from spontaneous emotional outburst, but from an elaborated destructive strategy where the agonistic nature of political discourse stipulates the use of instrumental aggression (Buss, 1971 for the sake of the conquest of power, lowering the

EXTRACSION: a system for automatic Eddy Current diagnosis of steam generator tubes in nuclear power plants

International Nuclear Information System (INIS)

Georgel, B.; Zorgati, R.

1992-01-01

Improving speed and quality of Eddy Current non-destructive testing of steam generator tubes leads to automation of all process that contribute to diagnosis. This paper describes how signal processing, pattern recognition and artificial and artificial intelligence are used to build a software package that is able to automatically provide an efficient diagnosis. (author)

Extraction: a system for automatic eddy current diagnosis of steam generator tubes in nuclear power plants

International Nuclear Information System (INIS)

Georgel, B.; Zorgati, R.

1994-01-01

Improving speed and quality of Eddy Current non-destructive testing of steam generator tubes leads to automatize all processes that contribute to diagnosis. This paper describes how we use signal processing, pattern recognition and artificial intelligence to build a software package that is able to automatically provide an efficient diagnosis. (authors). 2 figs., 5 refs

Status of the steam generator tube circumferential ODSCC degradation experienced at the Doel 4 plant

International Nuclear Information System (INIS)

Roussel, G.

1997-01-01

Since the 1991 outage, the Doel Unit 4 nuclear power plant is known to be affected by circumferential outside diameter intergranular stress corrosion cracking at the hot leg tube expansion transition. Extensive non destructive examination inspections have shown the number of tubes affected by this problem as well as the size of the cracks to have been increasing for the three cycles up to 1993. As a result of the high percentage of tubes found non acceptable for continued service after the 1993 in-service inspection, about 1,700 mechanical sleeves were installed in the steam generators. During the 1994 outage, all the tubes sleeved during the 1993 outage were considered as potentially cracked to some extent at the upper hydraulic transition and were therefore not acceptable for continued service. They were subsequently repaired by laser welding. Furthermore all the tubes not sleeved during the 1993 outage were considered as not acceptable for continued service and were repaired by installing laser welded sleeves. During the 1995 outage, some unexpected degradation phenomena were evidenced in the sleeved tubes. This paper summarizes the status of the circumferential ODSCC experienced in the SG tubes of the Doel 4 plant as well as the other connected degradation phenomena

Ovarian, Fallopian Tube, and Primary Peritoneal Cancer Screening

Science.gov (United States)

... Reporting & Auditing Grant Transfer Grant Closeout Contracts & Small Business Training Cancer Training at NCI (Intramural) Resources for ... ovaries are a pair of organs in the female reproductive system . They are located in the pelvis , ...

Quality of pathology reports for advanced ovarian cancer: are we missing essential information? An audit of 479 pathology reports from the EORTC-GCG 55971/NCIC-CTG OV13 neoadjuvant trial

NARCIS (Netherlands)

Verleye, Leen; Ottevanger, Petronella B.; Kristensen, Gunnar B.; Ehlen, Tom; Johnson, Nick; van der Burg, Maria E. L.; Reed, Nick S.; Verheijen, René H. M.; Gaarenstroom, Katja N.; Mosgaard, Berit; Seoane, Jose M.; van der Velden, Jacobus; Lotocki, Robert; van der Graaf, Winette; Penninckx, Björn; Coens, Corneel; Stuart, Gavin; Vergote, Ignace

2011-01-01

To assess the quality of surgical pathology reports of advanced stage ovarian, fallopian tube and primary peritoneal cancer. This quality assurance project was performed within the EORTC-GCG 55971/NCIC-CTG OV13 study comparing primary debulking surgery followed by chemotherapy with neoadjuvant

Quality of pathology reports for advanced ovarian cancer

DEFF Research Database (Denmark)

Verleye, Leen; Ottevanger, Petronella B; Kristensen, Gunnar B

2011-01-01

To assess the quality of surgical pathology reports of advanced stage ovarian, fallopian tube and primary peritoneal cancer. This quality assurance project was performed within the EORTC-GCG 55971/NCIC-CTG OV13 study comparing primary debulking surgery followed by chemotherapy with neoadjuvant...

Quality of pathology reports for advanced ovarian cancer: are we missing essential information? An audit of 479 pathology reports from the EORTC-GCG 55971/NCIC-CTG OV13 neoadjuvant trial

NARCIS (Netherlands)

Verleye, L.I.A.; Ottevanger, P.B.; Kristensen, G.B.; Ehlen, T.; Johnson, N.; Burg, M.E. van der; Reed, N.S.; Verheijen, R.H.; Gaarenstroom, K.N.; Mosgaard, B.; Seoane, J.M.; Velden, J. Van der; Lotocki, R.; Graaf, W.T.A. van der; Penninckx, B.; Coens, C.; Stuart, G.; Vergote, I.

2011-01-01

OBJECTIVE: To assess the quality of surgical pathology reports of advanced stage ovarian, fallopian tube and primary peritoneal cancer. This quality assurance project was performed within the EORTC-GCG 55971/NCIC-CTG OV13 study comparing primary debulking surgery followed by chemotherapy with

Prolapso tubario poshisterectomía: Un caso raro de iatrogenia

OpenAIRE

Zighelboim, Itic; Kízer, Saúl; Gómez, Luis Gonzalo; Essenfeld, Harold

2004-01-01

Se describe un caso de prolapso de ampolla tubárica a cúpula vaginal poshisterectomía que ocasionó flujo y dispareunia. A case report of fallopian tube ampulla vaginal prolapsed after abdominal hysterectomy that caused vaginal discharge and dyspareunia.

Possible first occurrence of external corrosion on alloy 600TT tubes in France

International Nuclear Information System (INIS)

Boccanfuso, M.; Thebault, Y.; Massini, B.; Bigne, L.

2015-01-01

During the last decade, in different countries, several occurrences of external corrosion have been identified on steam generator (SG) tube bundles equipped with thermally treated 600 alloy. In France, this feedback leads EDF to enhance the SG inspection program. Nevertheless, until now, no damage of this type was reported. Recently, during in-service inspection at the Cattenom plant on a SG equipped with alloy 600TT tubes, Eddy current tests have highlighted a signal that could be related to external corrosion. The tube was removed and sent to the EDF hot laboratory for destructive examinations. Various exams were performed at different scales to characterize the causes of this NDT signal, the material properties and the residual stresses. The assessments carried out on the tube conclude that the source of the damage is external intergranular stress corrosion cracking, also called ODSCC (Outside Diameter Stress Corrosion Cracking) making it the first occurrence on the tube bundles made of alloy 600TT in the French fleet. This first case of 600 TT ODSCC in France is an unexpected and particular one, because of its altitude in the full mechanical rolling area. This is reinforced by the low number of occurrences noted to date (only one after nearly 30 years of operation of alloy 600TT tube bundles). International (Biblis) OPEX had identified recent IGSCC with cracks initiated and propagated in the tubesheet. For this case, the scenario considered requires highly restrictive conditions (tube in the sludge zone and on the periphery of the tube bundle, including the tube lane) and may explain the singular nature of the Cattenom tube

Fast fracture of a zirconium alloy pressure tube: cause and implications

International Nuclear Information System (INIS)

Price, E.G.; Cheadle, B.A.

1985-12-01

The cause of the unstable fracture of a Zircaloy-2 pressure tube in the core of a CANDU reactor is reviewed. Failure was associated with the presence of brittle zones of zirconium hydride which developed as a result of thermal gradient induced hydrogen diffusion. Unstable fracture occurred when the partial thickness crack reached an unstable length and the crack ran 2 meters along the tube and terminated by circumferential tearing. The partial thickness defect initiated and propagated to an unstable length by delayed hydride cracking is high compared to fatigue progression and increases exponentially with temperature. Delayed hydride cracking can be prevented by reducing residual stresses to a minimum and by high standards of non-destructive testing that ensures freedom from unacceptable defects. Future prevention of fast fracture is based upon the inspection of a limited number of fuel channels for the presence of defects and for conditions which can cause hydride build-up together with the periodic removal of Zr-2.5wt% Nb tubes to monitor their condition

Some engineering aspects of the investigation into the cracking of pressure tubes in the Pickering reactors

International Nuclear Information System (INIS)

Ross-Ross, P.A.; Towgood, G.R.; Hunter, T.A.

1976-01-01

In August 1974, Pickering Unit 3 (514 MWe) was shutdown for a period of 8 months because of cracks in 17 of the 390 pressure tubes. The cracks were a result of incorrect installation procedures during construction. Improper positioning of the rolling tool used to join the Zr-2.5 wt% Nb pressure tube to the end fitting produced very high residual tensile stresses. High stresses in combination with periods with the tubes cold caused the cracking. Crack propagation was by fracture of hydrides which are brittle when cold. Subsequent investigation confirmed that properly rolled joints are not susceptible to such cracking. The resources of Canadian industry, Ontario Hydro and Atomic Energy of Canada were coordinated to find engineering solutions to the crack program. The defective tubes were removed from reactor, thoroughly examined to identify the cause of the cracks, and thoroughly tested to prove safety. Non-destructive techniques were quickly adopted for inspection of tubes in Pickering. Tools and procedures for retubing the 17 channels were prepared and Pickering Unit 3 was returned to service at the end of March 1975. (author)

Non-destructive Assessment of Relief Marking Parameters of Heat Shrinkable Installation Parts for Aviation Technology

Directory of Open Access Journals (Sweden)

Kondratov Aleksandr P.

2017-01-01

Full Text Available The article explains a new method of relief marking of heat-shrinkable tubing and sleeves made of polymer materials with “shape memory effect.” Method of instrument evaluation of relief marking stereometry of installation parts for aviation equipment, made of polyvinyl chloride, polyethyleneterephthalate and polystyrene was developed and the results were explained. Parameters of pin-point relief marking and compliance of point forms to the Braille font standard were determined with the use of the non-destructive method based on the color of interference pattern with precision of 0.02 mm.

Primary umbilical endometriosis: To scope or not to scope?

African Journals Online (AJOL)

only partially understood. Endometriosis usually occurs within the pelvic cavity. Common locations are the uterine wall, the fallopian tubes, the ovaries and the pelvic peritoneum.[3-5] Pelvic endometriosis presents clinically with a triad of symptoms: pain (chronic pelvic pain and dysmenorrhea), menorrhagia and infertility.

Serous tubal intraepithelial neoplasia : The concept and its application

NARCIS (Netherlands)

Meserve, Emily E. K.; Brouwer, Jan; Crum, Christopher P.

In recent years it has become clear that many extra-uterine (pelvic) high-grade serous carcinomas (serous carcinomas) are preceded by a precursor lesion in the distal fallopian tube. Precursors range from small self-limited 'p53 signatures' to expansile serous tubal intraepithelial neoplasms that

Ovarian Cancer Stage IIIC

Science.gov (United States)

... Stage IIIC Description: Drawing of stage IIIC shows cancer inside both ovaries that has spread to the omentum. The cancer ... lymph nodes behind the peritoneum. In stage IIIC, cancer is found in one or both ovaries or fallopian tubes and has spread to the ...

LAPROSCOPIC EVALUATION OF FEMALE SUBFERTILITY

OpenAIRE

Dilip Kuma; Diptanu

2015-01-01

Infertility is inability to ensure child bearing when it is wanted. Prevalence of infertility is going on increasing because of delayed marriage and pelvic infection and so on. Traditional way to assess uterine cavity, fallopian tubes, cervix by hysterosalphingography has now largely replaced by laprohysteroscopy.

Indirect Self-Destructiveness and Emotional Intelligence.

Science.gov (United States)

Tsirigotis, Konstantinos

2016-06-01

While emotional intelligence may have a favourable influence on the life and psychological and social functioning of the individual, indirect self-destructiveness exerts a rather negative influence. The aim of this study has been to explore possible relations between indirect self-destructiveness and emotional intelligence. A population of 260 individuals (130 females and 130 males) aged 20-30 (mean age of 24.5) was studied by using the Polish version of the chronic self-destructiveness scale and INTE, i.e., the Polish version of the assessing emotions scale. Indirect self-destructiveness has significant correlations with all variables of INTE (overall score, factor I, factor II), and these correlations are negative. The intensity of indirect self-destructiveness differentiates significantly the height of the emotional intelligence and vice versa: the height of the emotional intelligence differentiates significantly the intensity of indirect self-destructiveness. Indirect self-destructiveness has negative correlations with emotional intelligence as well as its components: the ability to recognize emotions and the ability to utilize emotions. The height of emotional intelligence differentiates the intensity of indirect self-destructiveness, and vice versa: the intensity of indirect self-destructiveness differentiates the height of emotional intelligence. It seems advisable to use emotional intelligence in the prophylactic and therapeutic work with persons with various types of disorders, especially with the syndrome of indirect self-destructiveness.

Probabilistic methodology for assessing steam generator tube inspection - Phase II: User's manual for CANTIA Version 1.1

International Nuclear Information System (INIS)

Harris, J.E.; Gorman, J.A.; Turner, A.P.L.

1997-03-01

The objectives of this project were to develop a computer-based method for probabilistic assessment of inspection strategies for steam generator tubes, and to document the source code and to provide a user's manual for it. The program CANTIA was created to fulfill this objective, and the user's manual is provided in this volume. The documentation and verification of the CANTIA code is provided as a separate report. CANTIA uses Monte Carlo techniques to determine approximate probabilities of steam generator tube failures under accident conditions and primary-to-secondary leak rates under normal and accident conditions at future points in time. The program also determines approximate future flaw distributions and non-destructive examination results from the input data. The probabilities of failure and leak rates and the future flaw distributions can be influenced by performing inspections of the steam generator tubes at some future points in time, and removing defective tubes from the population. The effect of different inspection and maintenance strategies can therefore be determined as a direct effect on the probability of tube failure and primary-to-secondary leak rate

Fast breeder cladding tubes provided with helical fins

International Nuclear Information System (INIS)

Baumgaertner, E.; Hoffmann, H.; Miller, H.; Jacobi, O.; Bojarski, E.; Freund, D.; Reiser, H.

1977-04-01

Development of fast breeder tubes with helical fins started around 1966. The development was initiated mainly by the search for a more favorable alternative to the conventional spacers such as grids and spiral wires. First of all the possibility was investigated of fabricating them on an industrial scale. The first thermohydraulic and fluiddynamic tests were made in parallel by AEG, GfK and Interatom. Besides the possibility of industrial fabrication the problems of non-destructive testing for geometry and material defects had to be treated with priority. In this report the different stages of development are shown and, finally, two rather large projects are described. These projects are the study ready for the licensing procedure concerning the irradiation of finned tube oxide fuel elements in KNK II and the already completed 19-rod fuel element bundle irradiation experiment Mol 7D of GfK performed in the 500 kW sodium loop of the Belgian BR2 reactor. In this BR2 experiment the maximum target burnup of 85,000 MWd/t of oxide was attained without trouble. (orig.) [de

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African Journals Online (AJOL)

abp

2015-11-19

Nov 19, 2015 ... peritoneal factors are responsible for about 30-40% of cases of female infertility and hence ... structural abnormalities of the uterus, endometriosis and fallopian tube patency were sought for. Tubal .... misinterpreted as tubal patency with peritoneal diffusion of contrast material. Another explanation is that, ...

Oophorectomy (Ovary Removal Surgery)

Science.gov (United States)

... oophorectomy may be performed for: A tubo-ovarian abscess — a pus-filled pocket involving a fallopian tube and an ovary Ovarian cancer Endometriosis Noncancerous (benign) ovarian tumors or cysts Reducing the risk of ovarian cancer or breast cancer in those at increased risk Ovarian torsion — ...

TropJrnal Vol 30 No 2 PDF

African Journals Online (AJOL)

Mr Olusoji

others were bacterial vaginosis (18.4%), Chlamydia cervicitis ( 17.6% ), trichomoniasis (11.2% ), and gonorrhea ( 2.4 % ). Conclusion: The procedure of HSG is invasive and asymptomatic infections in the cervix can be dislodged and propagated by injection of contrast to the fallopian tubes thus causing tubal blockage.

Menstrual Problems (For Parents)

Science.gov (United States)

... adenomyosis (when tissue that usually lines the uterus grows into the muscular wall of the uterus). Having cramps for a day or two each month is common, but if your daughter has symptoms severe ... uterus starts to grow outside the uterus — in the ovaries, fallopian tubes, ...

Pituitary adenylate cyclase activating polypeptide induces vascular relaxation and inhibits non-vascular smooth muscle activity in the rabbit female genital tract

DEFF Research Database (Denmark)

Steenstrup, B R; Ottesen, B; Jørgensen, M

1994-01-01

In vitro effects of two bioactive forms of pituitary adenylate cyclase activating polypeptide (PACAP): PACAP-38 and PACAP-27 were studied on rabbit vascular and non-vascular smooth muscle. Segments of the ovarian artery and muscle strips from the fallopian tube were used. Two series of experiment...

Small RNA sequencing reveals a comprehensive miRNA signature of BRCA1-associated high-grade serous ovarian cancer

NARCIS (Netherlands)

Brouwer, Jan; Kluiver, Joost; de Almeida, Rodrigo C.; Modderman, Rutger; Terpstra, Martijn; Kok, Klaas; Withoff, Sebo; Hollema, Harry; Reitsma, Welmoed; de Bock, Geertruida H.; Mourits, Marian J. E.; van den Berg, Anke

2016-01-01

AimsBRCA1 mutation carriers are at increased risk of developing high-grade serous ovarian cancer (HGSOC), a malignancy that originates from fallopian tube epithelium. We aimed to identify differentially expressed known and novel miRNAs in BRCA1-associated HGSOC. Methods Small RNA sequencing was

Non destructive methods applied on condenser tubes of copper alloys, stainless steel and titanium in the various standards and specifications

International Nuclear Information System (INIS)

Richter, H.; Heckhaeuser, H.

1982-01-01

For condenser tubes the Eddy current method is mostly applied and is found to be a suitable instrument to fulfil the demand to segregate tubes with harmful, injurious defects. Depending on individual special requirements ultrasonic testing may be performed as a additional test to increase the defect detection probability. Most standards applicable for condenser tubes do give preference the exclusive requirements ''test standard'' and ''sensitivity level'' which practically cannot maintain identical or strictly comparable test results relating to different equipment and test data. For a mutual understanding between the various partners involved additional test data should be taken into consideration as to allow clear interpretations of results anticipated. The type of artificial defects specified should take into account, that the exclusive mean of this defect is to establish the sensitivity and not to simulate any natural defect occuring in the tube to be tested. Regarding the physical interactions of EC and UT is recommended to specify bore holes drilled through the wall for EC and longitudinal notches on outside and/or inside surface for UT. For setting purpose the size of bore hole and notch should be selected such as to maintain easy reproducable preparation and sufficient clear and reliable responses

Oxidation and deuterium uptake of Zr-2.5Nb pressure tubes in CANDU-PHW reactors

International Nuclear Information System (INIS)

Urbanic, V.F.; Warr, B.D.; Manolescu, A.; Chow, C.K.; Shanahan, M.W.

1989-01-01

Oxidation and deuterium uptake in Zr-2.5Nb pressure tubes are being monitored by destructive examination of tubes removed from commercial Canadian deuterium uranium pressurized heavy-water (CANDU-PHW) stations and by analyses of microsamples, obtained in-situ, from the inside surface of tubes in the reactor. Unlike Zircaloy-2, there is no evidence for any acceleration in the oxidation rate for exposures up to about 4500 effective full power days. Changes towards a more equilibrium microstructure during irradiation may be partly responsible for maintaining the low oxidation rate, since thermal aging treatments, producing similar microstructural changes in initially cold worked tubes, were found to improve out-reactor corrosion resistance in 589 K water. With one exception, the deuterium uptake in Zr-2.5Nb tubes has been remarkably low and no greater than 3-mg/kg deuterium per year (0.39 mg/dm 2 hydrogen per year) . The exception is the most recent surveillance tube removed from Pickering (NGS) Unit 3, which had a deuterium content near the outlet end about five times higher than that seen in the previous tube examined. Current investigations suggest that most of the uptake in that tube may have come from the gas annulus surrounding the tube where deuterium exists as an impurity, and oxidation has been insufficient to maintain a protective oxide film. Results from weight gain measurements, chemical analyses, metallography, scanning electron microscopy, and transmission electron microscopy of irradiated pressure tubes and of small coupons exposed out reactor are presented and discussed with respect to the observed corrosion and hydriding behavior of CANDU-PHW pressure tubes. (author)

[Preneoplasias of ovarian carcinoma: biological and clinical aspects of different pathways of tumorigenesis].

Science.gov (United States)

Staebler, A

2011-11-01

Ovarian carcinomas consist of a heterogeneous group of malignant epithelial neoplasms with specific pathogenic mechanisms. This review provides a brief introduction to the different pathways of tumor progression and the associated molecular changes. However, the main focus will be on two areas with major paradigm shifting developments in recent years. Mutational analysis of ovarian clear cell carcinomas, endometrioid carcinomas and endometriotic lesions identified mutations in the ARID1A gene as common and early genetic changes in carcinomas with associated endometriosis and in atypical endometriosis itself. Extensive pathological work-up of the fallopian tubes of BRCA1/2 mutation carriers have demonstrated the existence of serous tubal intraepithelial carcinomas (STIC). Further studies showed that this lesion can also be found in 50-60% of patients with serous ovarian carcinomas without BRCA1/2 germline mutations. Pre-precursors which share the p53 mutations with STICs but proliferate very little are called p53-signatures and provide conclusive evidence that STICs develop in the fallopian tubes.

Surgical aspects of removal of Essure microinsert.

Science.gov (United States)

Albright, Catherine M; Frishman, Gary N; Bhagavath, Bala

2013-09-01

Essure is designed as a hysteroscopically placed permanent birth control. Removal of the Essure microinsert can be a technically challenging procedure. Requests for removal are uncommon but do occur. Although hysteroscopic and laparoscopic removal has been reported, there is limited information available describing appropriate surgical technique. There have been six patients requesting Essure removal at our institution (one approximately 2 years after placement). Based on this experience, we have developed specific counseling points and surgical principles for laparoscopic removal: avoid injection of a hemostatic solution into the fallopian tube; avoid excessive traction on the coils; avoid cauterization of the outer coil; follow the Essure coil into the interstitial end of the fallopian tube to ensure complete removal of the insert; perform a salpingectomy rather than a salpingostomy. By taking into account these principles, key preoperative counseling points can be discussed, and laparoscopic Essure removal years after placement can be accomplished in a safe and deliberate fashion. Copyright © 2013 Elsevier Inc. All rights reserved.

Hysteroscopic tubal sterilization: a health economic literature review.

Science.gov (United States)

2013-01-01

Hysteroscopic sterilization is a minimally invasive alternative to laparoscopic tubal ligation for women who want permanent contraception. In contrast to the laparoscopic technique, a hysteroscope is used to pass permanent microinserts through the cervix and place them in the fallopian tubes. This procedure does not require local or general anesthesia and can be performed in an office setting. The objective of this analysis was to determine, based on published literature, the cost-effectiveness of hysteroscopic tubal sterilization (HS) compared with laparoscopic tubal ligation (LS) for permanent female sterilization. A systematic literature search was conducted for studies published between January 1, 2008, and December 11, 2012. Potentially relevant studies were identified based on the title and abstract. Cost-utility analyses (studies that report outcomes in terms of costs and quality-adjusted life-years) were prioritized for inclusion. When not available, cost-effectiveness, cost-benefit, and cost-consequence analyses were considered. Costing studies were considered in the absence of all other analyses. A total of 33 abstracts were identified. Three cost analyses were included. A retrospective chart review from Canada found that HS was $111 less costly than LS; a prospective activity-based cost management study from Italy reported that it was €337 less costly than LS; and the results of an American decision model showed that HS was $1,178 less costly than LS. All studies had limited applicability to the Ontario health care system due to differences in setting, resource use, and costs. Three cost analyses found that, although the HS procedure was more expensive due to the cost of the microinserts, HS was less costly than LS overall due to the shorter recovery time required. Hysteroscopic sterilization is a minimally invasive alternative to conventional tubal ligation for women who want a permanent method of contraception. Both approaches involve closing off the

Vibration impact acoustic emission technique for identification and analysis of defects in carbon steel tubes: Part B Cluster analysis

Energy Technology Data Exchange (ETDEWEB)

Halim, Zakiah Abd [Universiti Teknikal Malaysia Melaka (Malaysia); Jamaludin, Nordin; Junaidi, Syarif [Faculty of Engineering and Built, Universiti Kebangsaan Malaysia, Bangi (Malaysia); Yahya, Syed Yusainee Syed [Universiti Teknologi MARA, Shah Alam (Malaysia)

2015-04-15

Current steel tubes inspection techniques are invasive, and the interpretation and evaluation of inspection results are manually done by skilled personnel. Part A of this work details the methodology involved in the newly developed non-invasive, non-destructive tube inspection technique based on the integration of vibration impact (VI) and acoustic emission (AE) systems known as the vibration impact acoustic emission (VIAE) technique. AE signals have been introduced into a series of ASTM A179 seamless steel tubes using the impact hammer. Specifically, a good steel tube as the reference tube and four steel tubes with through-hole artificial defect at different locations were used in this study. The AEs propagation was captured using a high frequency sensor of AE systems. The present study explores the cluster analysis approach based on autoregressive (AR) coefficients to automatically interpret the AE signals. The results from the cluster analysis were graphically illustrated using a dendrogram that demonstrated the arrangement of the natural clusters of AE signals. The AR algorithm appears to be the more effective method in classifying the AE signals into natural groups. This approach has successfully classified AE signals for quick and confident interpretation of defects in carbon steel tubes.

Vibration impact acoustic emission technique for identification and analysis of defects in carbon steel tubes: Part B Cluster analysis

International Nuclear Information System (INIS)

Halim, Zakiah Abd; Jamaludin, Nordin; Junaidi, Syarif; Yahya, Syed Yusainee Syed

2015-01-01

Current steel tubes inspection techniques are invasive, and the interpretation and evaluation of inspection results are manually done by skilled personnel. Part A of this work details the methodology involved in the newly developed non-invasive, non-destructive tube inspection technique based on the integration of vibration impact (VI) and acoustic emission (AE) systems known as the vibration impact acoustic emission (VIAE) technique. AE signals have been introduced into a series of ASTM A179 seamless steel tubes using the impact hammer. Specifically, a good steel tube as the reference tube and four steel tubes with through-hole artificial defect at different locations were used in this study. The AEs propagation was captured using a high frequency sensor of AE systems. The present study explores the cluster analysis approach based on autoregressive (AR) coefficients to automatically interpret the AE signals. The results from the cluster analysis were graphically illustrated using a dendrogram that demonstrated the arrangement of the natural clusters of AE signals. The AR algorithm appears to be the more effective method in classifying the AE signals into natural groups. This approach has successfully classified AE signals for quick and confident interpretation of defects in carbon steel tubes.

Vibration impact acoustic emission technique for identification and analysis of defects in carbon steel tubes: Part A Statistical analysis

Energy Technology Data Exchange (ETDEWEB)

Halim, Zakiah Abd [Universiti Teknikal Malaysia Melaka (Malaysia); Jamaludin, Nordin; Junaidi, Syarif [Faculty of Engineering and Built, Universiti Kebangsaan Malaysia, Bangi (Malaysia); Yahya, Syed Yusainee Syed [Universiti Teknologi MARA, Shah Alam (Malaysia)

2015-04-15

Current steel tubes inspection techniques are invasive, and the interpretation and evaluation of inspection results are manually done by skilled personnel. This paper presents a statistical analysis of high frequency stress wave signals captured from a newly developed noninvasive, non-destructive tube inspection technique known as the vibration impact acoustic emission (VIAE) technique. Acoustic emission (AE) signals have been introduced into the ASTM A179 seamless steel tubes using an impact hammer, and the AE wave propagation was captured using an AE sensor. Specifically, a healthy steel tube as the reference tube and four steel tubes with through-hole artificial defect at different locations were used in this study. The AE features extracted from the captured signals are rise time, peak amplitude, duration and count. The VIAE technique also analysed the AE signals using statistical features such as root mean square (r.m.s.), energy, and crest factor. It was evident that duration, count, r.m.s., energy and crest factor could be used to automatically identify the presence of defect in carbon steel tubes using AE signals captured using the non-invasive VIAE technique.

Non-Destructive Method by Gamma Sampling Measurements for Radiological Characterization of a Steam Generator: Physical and Numerical Modeling for ANIMMA (23-27 June 2013)

International Nuclear Information System (INIS)

Auge, G.; Rottner, B.; Dubois, C.

2013-06-01

The radiological characterization of a steam generator consists of evaluating the global radiological activity in the tube bundle. In this paper, we present a non-destructive method and the results analysis of the gamma sampling measurements from a sample of U-tubes in the bundle. On site, the implementation of the methodology is fairly easy. But the analysis of the results is more complicated due to the long path of the gamma ray (from 60 Co quite penetrating), and also the heterogeneous activity of U-tubes bundle, which have not the same life cycle. We explain why the periodic spatial arrangement complicates also the analysis. Furthermore, we have taken into account the environment of all tubes measured because of all the external influence activity of others U-tubes (the nearest, the most distant and potential hot spot). A great amount of independent influence coefficient had to be considered (roughly 18 million). Based on a physical and numerical modeling, and using a Cholesky algorithm solving the problem and saving time machine. (authors)

Non-destructive inservice inspections

International Nuclear Information System (INIS)

Kauppinen, P.; Sarkimo, M.; Lahdenperae, K.

1998-01-01

In order to assess the possible damages occurring in the components and structures of operating nuclear power plants during service the main components and structures are periodically inspected by non-destructive testing techniques. The reliability of non-destructive testing techniques applied in these inservice inspections is of major importance because the decisions concerning the needs for repair of components are mainly based on the results of inspections. One of the targets of this research program has been to improve the reliability of non-destructive testing. This has been addressed in the sub-projects which are briefly summarised here. (author)

Overview of steam generator tube-inspection technology

International Nuclear Information System (INIS)

Obrutsky, L.; Renaud, J.; Lakhan, R.

2014-01-01

Degradation of steam generator (SG) tubing due to both mechanical and corrosion modes has resulted in extensive repairs and replacement of SGs around the world. The variety of degradation modes challenges the integrity of SG tubing and, therefore, the stations' reliability. Inspection and monitoring aimed at timely detection and characterization of the degradation is a key element for ensuring tube integrity. Up to the early-70's, the in-service inspection of SG tubing was carried out using single-frequency eddy current testing (ET) bobbin coils, which were adequate for the detection of volumetric degradation. By the mid-80's, additional modes of degradation such as pitting, intergranular attack, and axial and circumferential inside or outside diameter stress corrosion cracking had to be addressed. The need for timely, fast detection and characterization of these diverse modes of degradation motivated the development in the 90's of inspection systems based on advanced probe technology coupled with versatile instruments operated by fast computers and remote communication systems. SG inspection systems have progressed in the new millennium to a much higher level of automation, efficiency and reliability. Also, the role of Non Destructive Evaluation (NDE) has evolved from simple detection tools to diagnostic tools that provide input into integrity assessment decisions, fitness-far-service and operational assessments. This new role was motivated by tighter regulatory requirements to assure the safety of the public and the environment, better SG life management strategies and often self-imposed regulations. It led to the development of advanced probe technologies, more reliable and versatile instruments and robotics, better training and qualification of personnel and better data management and analysis systems. This paper provides a brief historical perspective regarding the evolution of SG inspections and analyzes the motivations behind that evolution. It presents an

Extra Ovarian Serous Cystadenocarcinoma in the Broad Ligament ...

African Journals Online (AJOL)

The embryonic remnants of the gonadal ridge and the genital duct apparatus, the Mullerian apparatus, remain atretic throughout the life of a woman. The definitive organs arising from these, the Ovary, Fallopian tubes, Uterus, Cervix and the Broad ligaments share common coelomic origin. Epithelial metaplasia in any of ...

Surfactant protein D in the female genital tract

DEFF Research Database (Denmark)

Leth-Larsen, Rikke; Floridon, C; Nielsen, O

2004-01-01

, cervix, uterus, fallopian tubes and ovaries. In the placenta, SP-D was seen in all villous and extravillous trophoblast subpopulations. Endometrial presence of SP-D in non-pregnant women varied according to stage of the menstrual cycle and was up-regulated towards the secretory phase. It is suggested...

Interruption of CXCL13-CXCR5 Axis Increases Upper Genital Tract Pathology and Activation of NKT Cells following Chlamydial Genital Infection

NARCIS (Netherlands)

Jiang, Janina; Karimi, Ouafae; Ouburg, Sander; Champion, Cheryl I.; Khurana, Archana; Liu, Guangchao; Freed, Amanda; Pleijster, Jolein; Rozengurt, Nora; Land, Jolande A.; Surcel, Helja-Marja; Tiitinen, Aila'; Paavonen, Jorma; Kronenberg, Mitchell; Morre, Servaas A.; Kelly, Kathleen A.

2012-01-01

Background: Regulation of immune responses is critical for controlling inflammation and disruption of this process can lead to tissue damage. We reported that CXCL13 was induced in fallopian tube tissue following C. trachomatis infection. Here, we examined the influence of the CXCL13-CXCR5 axis in

47,XYY karyotype and normal SRY in a patient with a female phenotype.

Science.gov (United States)

Benasayag, S; Rittler, M; Nieto, F; Torres de Aguirre, N; Reyes, M; Copelli, S

2001-06-01

A rare case of a female patient with a 47,XYY karyotype is described. She had normal female external genitalia, bilateral testes, rudimentary Fallopian tubes and no uterus. Molecular analysis revealed a normal SRY encoding sequence. The possible events in the etiology of this sex reversal entity are discussed.

Clinical and logistical aspects of in vitro fertilization treatment: An analysis of a transport IVF programme

NARCIS (Netherlands)

J. Roest (Jan)

1997-01-01

textabstractIn vitro fertilization and cmblYo transfer (IVFIET), the culture of aspirated aGcytcs and spermatozoa in the JaboratOly follO\\\\ved by transccrvicai embryo transfer, ,vas originally used as a treatment for infertility resulting from impaired fUllction of the fallopian tubes. A few years

LAPROSCOPIC EVALUATION OF FEMALE SUBFERTILITY

Directory of Open Access Journals (Sweden)

Dilip Kuma

2015-11-01

Full Text Available Infertility is inability to ensure child bearing when it is wanted. Prevalence of infertility is going on increasing because of delayed marriage and pelvic infection and so on. Traditional way to assess uterine cavity, fallopian tubes, cervix by hysterosalphingography has now largely replaced by laprohysteroscopy.

ISSN 2073 ISSN 2073 9990 East Cent. Afr. J. 9990 East Cent. Afr. J ...

African Journals Online (AJOL)

Hp 630 Dual Core

Considering it an ovarian malignancy laparotomy was planned for the patient. Peroperatively, omentum was ... came out. The wall of cyst sent for frozen section and it revealed adenocarcinoma. Then total ... Histopathological examination revealed normal uterus and cervix right and left ovary and left fallopian tube. The right ...

Use of Hysterosalpingo-Foam Sonography for Assessment of the Efficacy of Essure Hysteroscopic Sterilization.

Science.gov (United States)

Rosič, Maja; Žegura, Branka; Vadnjal Đonlagić, Sabina

2018-01-18

Hysterosalpingo-foam sonography (HyFoSy) has been suggested to be a possible less invasive alternative to hysterosalpingography (HSG), which is the reference standard for confirmation of tubal occlusion after Essure (Bayer AG, Leverkusen, Germany) hysteroscopic sterilization. The purpose of our study was to evaluate the accuracy of HyFoSy compared to HSG for confirmation of tubal occlusion after Essure hysteroscopic sterilization. A prospective study included 90 patients who underwent Essure hysteroscopic sterilization. Twelve weeks after the sterilization, 2-dimensional transvaginal ultrasonography was performed to assess the microinsert position and was followed by HyFoSy and HSG for evaluation of tubal occlusion. Patients with patent fallopian tubes on HSG were scheduled for additional HSG procedures at 3-month intervals until tubal occlusion was documented. Of 90 enrolled patients, 86 patients with 170 fallopian tubes underwent the complete imaging protocol. Tubal occlusion was evaluated by HyFoSy as an index test and HSG as a reference standard. The accuracy of HyFoSy was 97.1% (95% confidence interval [CI], 93%-99%). The sensitivity and specificity were 100% (95% CI, 97%-100%) and 54.6% (95% CI, 23%-83%), whereas the positive and negative predictive values were 97.0% (95% CI, 93%-99%) and 100% (95% CI, 42%-100%), respectively. No long-term complications were reported for HyFoSy or HSG. Given that the concordance rate for tubal occlusion between HyFoSy and HSG was not 100%, an occluded fallopian tube on HyFoSy should be confirmed by HSG, which remains the reference standard for confirmation of tubal occlusion after Essure hysteroscopic sterilization. © 2018 by the American Institute of Ultrasound in Medicine.

Analytical Approximation of Spectrum for Pulse X-ray Tubes

International Nuclear Information System (INIS)

Vavilov, S; Fofanof, O; Koshkin, G; Udod, V

2016-01-01

Among the main characteristics of the pulsed X-ray apparatuses the spectral energy characteristics are the most important ones: the spectral distribution of the photon energy, effective and maximum energy of quanta. Knowing the spectral characteristics of the radiation of pulse sources is very important for the practical use of them in non-destructive testing. We have attempted on the analytical approximation of the pulsed X-ray apparatuses spectra obtained in the different experimental papers. The results of the analytical approximation of energy spectrum for pulse X-ray tube are presented. Obtained formulas are adequate to experimental data and can be used by designing pulsed X-ray apparatuses. (paper)

Examination of the SG tube fatigue cracking at Fessenheim unit no.2 of EDF

International Nuclear Information System (INIS)

Boccanfuso, M.; Lorthios, J.; Thebault, Y.; Bruyere, B.; Duisabeau, L.; Herms, E.

2015-01-01

In February 2008, a primary-to-secondary leak occurred at Fessenheim Unit No.2 on a steam generator. A circumferential fatigue crack was observed at the upper tube support plate level of the R12C62 tube although the stability ratio evaluation performed to take into account some prior international events, concluded that this tube had no risk of fluid-elastic instability. A new tube pull process was developed and performed by AREVA in 2011 just before the SG replacement. The extraction at the uppermost TSP elevation was a first occurrence in the French EDF PWR. Destructive examinations were carried out in the EDF hot laboratory of CEIDRE/Chinon in order to characterize damage mechanisms at the initiation and propagation stage. The document relates the major results of laboratory examinations leading us to exclude the fluid-elastic instability scenario as previously reported in North-Anna (1987) and Mihama (1991) tube rupture incidents. Results analysis with particular focus on the fracture surface description using Scanning Electron microscopy observations and metallurgical investigations provide new elements concerning the aggravating factors of fatigue damage. Fracture surface investigations reveal that the circumferential crack was due to high cycle fatigue with a very low stress intensity factor. Some aggravating factors like intergranular corrosion appeared to be critical for the fatigue cracking initiation stage. The deterioration was also largely promoted by the lack of tube support at the Anti-Vibration Bars

Degradation of superheater tubes made of austenitic T321H steel after long term service

Energy Technology Data Exchange (ETDEWEB)

Hernas, Adam [Silesian Technical Univ., Katowice (Poland). Faculty of Material Science; Augustyniak, Boleslaw; Chmielewski, Marek [Gdansk Univ. of Technology (Poland). Mechanical Dept.; Sablik, M.J. [Applied Magnetic and Physical Modeling, LLC, San Antonio, TX (United States)

2010-07-01

There are presented results of complementary tests performed for the evaluation of creep damage in austenitic steel grade T321H exploited over 200,000 hours in the secondary superheater part of a power plant boiler. The following techniques have been applied: SEM microscopy, X-ray diffraction, tensile tests, hardness measurements and novel eddy current inspection. The novel eddy current inspection is proposed as a non-destructive method of estimating the creep damage stage of austenite steel boiler tubes after long-term service in power plants. We compare the results provided by the different techniques and discuss the correlations and also point out the problems which need to be addressed in order to elaborate the remaining life assessment of austenitic boiler tubes. (orig.)

Computer modelling of eddy current probes for ISI of pressure tube/calandria tube assemblies in PHWRs

International Nuclear Information System (INIS)

Rao, B.P.C.; Shyamsunder, M.T.; Bhattacharya, D.K.; Raj, Baldev

1992-01-01

Non-destructive Evaluation (NDE) plays a major role in ensuring the safe and reliable operation of PHWRs which are the mainstay of India's nuclear power programme. An important in-service inspection (ISI) requirement in these reactors is carried out through Eddy Current Testing (ECT) of the pressure tube (PT)/calandria tube (CT) assemblies. The material of construction of these assemblies is zircaloy-2. The two main objectives of this ISI are the detection of garter spring between CT and PT and the profiling of gap between CT and PT. The paper discusses the work carried out at the authors' laboratory on the development of ECT probes for ISI of PT/CT assemblies. Emphasis has been given on the work done on the design and optimisation of the probes using computer modeling. A 2-D finite element code has been developed for this purpose. The code is developed around a diffusion equation which can be derived from Maxwell's equations governing the electromagnetic phenomenon. An axisymmetry has been considered, since the probes are bobbin type. Results of impedance plane outputs obtained by modelling and those by experiments using actual probes have shown good matching. Salient features of an indigenously developed interactive PC based data acquisition, analysis and retrieval system to cater to ISI of PC/CT assemblies are described. (author). 10 refs., 7 figs

Examination of steam generator alloy 800 NG tube from the Almaraz unit 2 NPP

International Nuclear Information System (INIS)

Diego, G. de; Gomez Briceno, D.; Maffiotte, C.; Baladia, M.; Arias, C.J.

2015-01-01

The steam generators of Almaraz Unit 2 were replaced in 1997 by the model 61W/D3 (Siemens) with Alloy 800NG steam generator tubes. Denting indications were firstly detected in 2006 in the SG-3. Crack indications were identified in 2009. At the end of 2011, three tubes were recovered from this steam generator to carry out destructive examination in order to identify the root cause of the tubes degradation. Analysis of deposits point out the existence of multiples elements in the removed OD (Outer Diameter) deposits as well as in the deposits at the free tube under sludge and at the transition zone. Deposits are more abundant at the transition zone than at free tube. About 10% Na concentration has been detected, whereas S and Cl appear in small concentrations. Si appears regularly and Cr, Ni concentrations in the deposits are similar. Multiple intergranular cracks have been detected at 3 mm above the last contact point between the tube and the TS (tube support), in a band of around 5 mm, practically in the whole perimeter of the tube. Fracture surface of crack-B was partially covered by a Si rich layer, whereas fracture surface of crack-A seems to be cleaner. However, no significant differences in composition, except higher amount of S in crack-B, were found in the deposits of both cracks. EDX mapping and Auger profiles point out Ni enrichment with slight Cr enrichment or depletion and Fe depletion. The comparison of Auger profiles with available results for Alloy 800 tested in caustic and acid sulfate environments seems to indicate that the environment inside the cracks detected in the tube R67C48 is neutral or moderately caustic

Roll-expanded plugs for steam generator heating tubes verification of leak tightness over the component lifetime

International Nuclear Information System (INIS)

Beck, J.; Ziegler, R.; Schönheit, N.

2013-01-01

Highlights: • Design description of roll-expanded plugs. • Experimental simulation of 40 years lifetime of plugged steam generator tubes. • Destructive testing for off-design loads. • Evaluation of release pressure and tightness before and after the tests. -- Abstract: Steam generator heating tubes are the boundary between the irradiated primary cycle and the conventional secondary cycle in a pressurized water reactor. Despite their operational task to transfer the heat from the primary to the secondary cycle, these tubes have a crucial safety function: the retention of irradiated primary coolant inside the circuit in all operating, emergency and off-design conditions. The heating tubes are subject to various degradation mechanisms during operation. To verify the integrity of each single tube, nuclear power plants carry out frequent in-service inspections. In case of a tube wall degradation beyond the permissible limit, the tube needs to be taken out of service in order to maintain the overall component integrity. The most common method to do so is to plug a damaged tube by a roll-expanded plug. After plugging, the roll-expanded plug acts as pressure boundary between the primary and the secondary cycle instead of the damaged heating tube. The plug must be able to maintain this function, previously provided by the heating tube, in all operational, emergency and off-design conditions. This article describes the approach to this verification by launching several comprehensive process qualification programmes consisting of mechanical analyses as well as static and dynamic testing programmes. The result was a qualified roll-expanded plug which remains leak-tight even during off-design conditions

Diagnosis of 3-dimensional geometry and stress corrosion cracking in steam generator tubes

International Nuclear Information System (INIS)

Lee, D.H.; Choi, M.S.; Hur, D.H.; Kim, K.M.; Han, J.H.; Song, M.H.

2015-01-01

Most of the corrosive degradations in steam generator tubes of nuclear power plants are closely related to the residual stress existing in the local region of a geometric change, that is, an expansion transition, u-bend, dent, bulge, etc. Therefore, accurate information on a geometric anomaly (precursor of degradation) in a tube is a prerequisite to the activity of pre- and in-service non destructive inspection for a precise and earlier detection of a defect in order to prevent a failure during an operation, and also for a root cause analysis of a failure. In this paper, a new diagnostic eddy current probe technology which has simultaneous dual function of a 3-dimensional geometry measurement and defect detection in steam generator tube is introduced. The D-Probe is a rotary type eddy current coil probe equipped with 3 different eddy current coil units (surface riding type plus-point and pancake coils for defect detection, and non-surface riding type shielded high frequency pancake coil for tube profile measurement). A specific data analysis software has been developed. By comparing the eddy current data from the defect with those from the geometric changes, the relationship between the degradation and geometric changes can be revealed. Also, it supplies information on tube location at which defect is most probable and thus, a more efficient detection of earlier degradation. The use of D-probe and analysis software has been demonstrated for steam generator tubes with various geometric anomalies in manufacturing and operating nuclear power plants

Comparative study of destructive and non-destructive methods in the activation analysis of rocks

International Nuclear Information System (INIS)

Vasconcellos, M.B.A.

1978-01-01

A comparative study between non-destructive thermal neutron activation analysis and activation analysis with radiochemical group separation is made Both methods are applied to the determination of trace elements minor and major elements in rocks. The treatment of the rocks, with special reference to the problems related to grinding and contamination by foreign elements is described. The choice of standards for multielement trace activation analysis is discussed. Two types of computer programs for the evalution of data obtained through Ge-li detector counting are used. All the phases of the destructive and non destructive analysis are described. In the destructive analysis, an adaptation of the group separation scheme developed by Morrison et al for the activation analysis of geological samples is made. The changes introduced make the radiochemical separation simpler and more rapid. Both destructive and non destructive methods are tested by means of the analysis of the United States Geological Survey standard rock AGV-1, which has been analysed by many authors. The same procedure is then applied to some alcaline rocks taken from the apatite mine of Jacupiranga, in the State of Sao Paulo, Brazil. The knowledge of the trace element concentration in these rocks is important for geochemical studies. A detailed study of the possible interferences encountered in the neutron activation analysis of these rocks is made, considering the interferences due to major activities, and to the proximity of the several gamma ray energies of the radioisotopes produced. Finally, the comparative study between the two methods is presented, using statistical tests for the quantitative evalution of results. (Author) [pt

21 CFR 868.5800 - Tracheostomy tube and tube cuff.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Tracheostomy tube and tube cuff. 868.5800 Section... (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5800 Tracheostomy tube and tube cuff. (a) Identification. A tracheostomy tube and tube cuff is a device intended to be placed into a...

A comparison between destructive and non-destructive techniques in determining coating thickness

Science.gov (United States)

Haider, F. I.; Suryanto; Ani, M. H.; Mahmood, M. H.

2018-01-01

Measuring coating thickness is an important part in research works related to coating applications. In general, techniques for measuring coating thickness may be divided into destructive and non-destructive methods which are commonly used depending on the applications. The objective of this study is to compare two methods measuring the coating thickness of electroplating copper coating on the austenitic stainless-steel substrate. The electroplating was carried out in a solution containing 200 g/L CuSO4, 100 g/L H2SO4 at room temperature and current of 40mA/cm2 during 20, 40, 60, 80 and 100 mins as coating periods. And the coating thickness was measured by two methods, cross sectional analysis as a destructive technique and weight gain as a non-destructive technique. The results show that at 20 mins coating time interval, the thickness measured by cross sectional method was 16.67 μm and by weight gain method was 17.37 μm, with difference of 0.7 μm and percentage error of 4.11%. This error increased to 5.27% at 100mins time interval, where the values of the thickness measured by cross sectional and weight gain were 86.33 μm and 81.9 μm respectively, and the difference was 4.43 μm. Moreover, though the weight gain method is fast and gives the indication for the termination of a coating process, information regarding the uniformity, porosity and the presence of cracks cannot be obtained. On the other hand, determining the coating thickness using destructive method will damage the sample.

Advanced NDE (ANDE) and its application for pressure tube inspections in OPG reactors

Energy Technology Data Exchange (ETDEWEB)

Jarron, D.; Trelinski, M.; Kretz, S. [Ontario Power Generation, Ajax, Ontario (Canada)]. E-mail: don.jarron@opg.com; mike.trelinski@opg.com; steve.kretz@opg.com

2006-07-01

Periodic and in-service inspections of CANDU fuel channels are essential for the proper assessment of the structural integrity of these vital components. The arrival of new delivery devices for fuel channel inspections (Universal Delivery Machine) has driven new methods for gathering and analyzing NDE data. The Advanced Non-Destructive Examination (ANDE) system has been designed and field implemented as a high speed data acquisition system to meet the requirements of the CSA N285.4 code. It was built from the solid foundation of CIGAR experience and uses cutting edge hardware and software to attain high speed data collection enabling relatively quick inspection of a large number of fuel channels. The capabilities of the ANDE inspection system include: Surface and volumetric inspection of pressure tube by ultrasonics; Flaw characterization by ultrasonics; Pressure tube diameter measurements; Pressure tube thickness measurements; Garter Spring location by Eddy Current; Garter Spring location by ultrasonics; Pressure tube sag measurement. In addition to the above, selected flaws/areas of a pressure tube can be replicated using a two plate ANDE replica tool. At the heart of the inspection system is a set of twelve ultrasonic probes positioned in such a way that the inspected areas are examined from various angles and directions and by various ultrasonic wave modes (shear and longitudinal). High frequency ultrasound used for the examinations allows for reliable detection of small flaws. Separate sensors have been installed on the inspection head for Garter Spring location and sag measurements. (author)

Papillary tubal hyperplasia

DEFF Research Database (Denmark)

Kurman, Robert J; Vang, Russell; Junge, Jette

2011-01-01

that the small papillae and clusters of cells from the fallopian tube implant on ovarian and peritoneal surfaces to produce these lesions. The 7 JHH cases of PTH that were not associated with an ovarian tumor support the view that PTH is the likely precursor lesion. We propose a model for the development...

Destruction of chemical agent simulants in a supercritical water oxidation bench-scale reactor

Energy Technology Data Exchange (ETDEWEB)

Veriansyah, Bambang [Supercritical Fluid Research Laboratory, Clean Technology Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of) and Department of Green Process and System Engineering, University of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of)]. E-mail: vaveri@kist.re.kr; Kim, Jae-Duck [Supercritical Fluid Research Laboratory, Clean Technology Research Center, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of) and Department of Green Process and System Engineering, University of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791 (Korea, Republic of)]. E-mail: jdkim@kist.re.kr; Lee, Jong-Chol [Agency for Defense Development (ADD), P.O. Box 35-1, Yuseong-gu, Daejeon (Korea, Republic of)]. E-mail: jcleeadd@hanafos.com

2007-08-17

A new design of supercritical water oxidation (SCWO) bench-scale reactor has been developed to handle high-risk wastes resulting from munitions demilitarization. The reactor consists of a concentric vertical double wall in which SCWO reaction takes place inside an inner tube (titanium grade 2, non-porous) whereas pressure resistance is ensured by a Hastelloy C-276 external vessel. The performances of this reactor were investigated with two different kinds of chemical warfare agent simulants: OPA (a mixture of isopropyl amine and isopropyl alcohol) as the binary precursor for nerve agent of sarin and thiodiglycol [TDG (HOC{sub 2}H{sub 4}){sub 2}S] as the model organic sulfur heteroatom. High destruction rates based on total organic carbon (TOC) were achieved (>99.99%) without production of chars or undesired gases such as carbon monoxide and methane. The carbon-containing product was carbon dioxide whereas the nitrogen-containing products were nitrogen and nitrous oxide. Sulfur was totally recovered in the aqueous effluent as sulfuric acid. No corrosion was noticed in the reactor after a cumulative operation time of more than 250 h. The titanium tube shielded successfully the pressure vessel from corrosion.

Radiological Assessment Of The Uterus And Fallopian Tubes In ...

African Journals Online (AJOL)

Objectives: This study is aimed at determining the pattern of abnormalities in the Hysterosalpingograms of patients who attended the Radiology Unit of Ebonyi State University Teaching Hospital, Abakaliki. Method: The 188 hysterosalpingograms conducted between January 2002 to December 2005 were analysed. Results: ...

Type I collagen from bullfrog ( Rana catesbeiana ) fallopian tube ...

African Journals Online (AJOL)

Rana catesbeiana) with a yield of 16.4%, on a dry weight basis. Sodium dodecyl sulphate polyacylamide-gel electrophoresis (SDS-PAGE) showed that the PSC contained two alpha components (α1 and α2) and was classified as type I collagen ...

Tube plug

International Nuclear Information System (INIS)

Zafred, P. R.

1985-01-01

The tube plug comprises a one piece mechanical plug having one open end and one closed end which is capable of being inserted in a heat exchange tube and internally expanded into contact with the inside surface of the heat exchange tube for preventing flow of a coolant through the heat exchange tube. The tube plug also comprises a groove extending around the outside circumference thereof which has an elastomeric material disposed in the groove for enhancing the seal between the tube plug and the tube

Ultrasonic inspection of tube to tube plate welds

International Nuclear Information System (INIS)

Telford, D.W.; Peat, T.S.

1985-01-01

To monitor the deterioration of a weld between a tube and tube plate which has been repaired by a repair sleeve inside the tube and brazed at one end to the tube, ultrasound from a crystal at the end of a rod is launched, in the form of Lamb-type waves, into the tube through the braze and allowed to travel along the tube to the weld and be reflected back along the tube. The technique may also be used for the type of heat exchanger in which, during construction, the tubes are welded to the tube plate via external sleeves in which case the ultrasound is used in a similar manner to inspect the sleeve/tube plate weld. an electromagnetic transducer may be used to generate the ultrasound. The ultrasonic head comprising the crystal and an acoustic baffle is mounted on a Perspex (RTM) rod which may be rotated by a stepping motor. Echo signals from the region of deterioration may be isolated by use of a time gate in the receiver. The device primarily detects circumferentially orientated cracks, and may be used in heat exchangers in nuclear power plants. (author)

Predicted wear on the tube outside surface due to foreign object in the secondary side of steam generator

International Nuclear Information System (INIS)

Kim, Hyung Nam; Cho, Nam Cheoul

2012-01-01

It is necessary to evaluate the effects of foreign objects on steam generator tubes and to use this information to take appropriate safety precautions to prevent nuclear accidents. Foreign objects may include loose parts from the feed water system and items lost by workers during o/h, and may flow into the secondary side of steam generators during operation. A foreign object could damage steam generator tube walls if there is relative motion between the tube and the foreign object. This is especially true for foreign objects that land on the tube sheet because the velocity of cross flow, which creates a contact force between the tube and foreign object, is relatively high there. During steam generator overhauls, foreign objects are detected by non destructive methods such as the visual test and/or the eddy current test. Confirmed foreign objects should be removed for nuclear safety. The Foreign Object Search and Retrieval System (FOSAR) can be used to remove foreign objects from the steam generators with a square tube array. However, the FOSAR cannot be used (or can be used in only a very restricted area, such as the outside of the tube bundle) in the steam generators with a triangular tube array. In order to continue nuclear power plant operations without removing foreign objects, the integrity of the steam generator tube must be verified. This paper introduces a practical method developed to evaluate the effects of foreign objects detected on tube sheets in the secondary sides of steam generators

Development and validation of a simulation tool dedicated to eddy current non destructive testing of tubes

International Nuclear Information System (INIS)

Reboud, Ch.

2006-09-01

Eddy current testing (ECT) technique is widely used in industrial fields such as iron and steel industry. Dedicated simulation tools provide a great assistance for the optimisation of ECT processes. CEA and the Vallourec Research Center have collaborated in order to develop a simulation tool of ECT of tubes. The volume integral method has been chosen for the resolution of Maxwell equations in a stratified medium, in order to get accurate results with a computation time short enough to carry out optimisation or inversion procedures. A fast model has been developed for the simulation of ECT of non magnetic tubes using specific external probes. New flaw geometries have been modelled: holes and notches with flat bottom. Validations of the developments, which have been integrated to the CIVA platform, have been carried out using experimental data recorded in laboratory conditions and in. industrial conditions, successively. The integral equations derived are solved using the Galerkin variant of the method of moments with pulse functions as projection functions. In order to overcome some memory limitations, other projection functions have been considered. A new discretization scheme based on non-uniform B-Splines of degree 1 or 2 has been implemented, which constitutes an original contribution to the existing literature. The decrease of the mesh size needed to get a given accuracy on the result may lead to the simulation of more complex ECT configurations. (author)

Flash photolysis-shock tube studies

Energy Technology Data Exchange (ETDEWEB)

Michael, J.V. [Argonne National Laboratory, IL (United States)

1993-12-01

Even though this project in the past has concentrated on the measurement of thermal bimolecular reactions of atomic species with stable molecules by the flash or laser photolysis-shock tube (FP- or LP-ST) method using atomic resonance absorption spectrometry (ARAS) as the diagnostic technique, during the past year the authors have concentrated on studies of the thermal decompositions of selected chlorocarbon molecules. These studies are necessary if the degradation of chlorine containing organic molecules by incineration are to be understood at the molecular level. Clearly, destruction of these molecules will not only involve abstraction reactions, when possible, but also thermal decomposition followed by secondary reactions of the initially formed atoms and radicals. Studies on the thermal decomposition of CH{sub 3}Cl are complete, and the curve-of-growth for Cl-atom atomic resonance absorption has been determined. The new thermal decomposition studies are similar to those already reported for CH{sub 3}Cl.

Enhancing the capabilities of eddy current techniques for non-destructive evaluation of austenitic stainless steels

International Nuclear Information System (INIS)

Rao, B.P.C.; Thirunavukkarasu, S.; Sasi, B.; Jayakumar, T.; Baldev Raj

2010-01-01

Eddy current non-destructive evaluation (NDE) techniques find many applications during fabrication and in-service inspection of components made of stainless steel. In recent years, concurrent developments in electromagnetic field detection sensors such as giant magneto-resistive (GMR), giant-magneto impedance (GMI) and SQUIDs sensors, computers, microelectronics, and incorporating advanced signal and image processing techniques, have paved the way for enhancing the capabilities of existing eddy current (EC) techniques for examination of austenitic stainless steel (SS) plates, tubes and other geometries and several innovative methodologies have been developed. This paper highlights a few such applications in EC testing to austenitic stainless steel components used in fast reactors. (author)

Heat Exchanger Tube to Tube Sheet Joints Corrosion Behavior

Directory of Open Access Journals (Sweden)

M. Iancu

2013-03-01

Full Text Available Paper presents the studies made by the authors above the tube to tube sheet fittings of heat exchanger with fixed covers from hydrofining oil reforming unit. Tube fittings are critical zones for heat exchangers failures. On a device made from material tube and tube sheet at real joints dimensions were establish axial compression force and traction force at which tube is extracted from expanded joint. Were used two shapes joints with two types of fittings surfaces, one with smooth hole of tube sheet and other in which on boring surface we made a groove. From extracted expanded tube zones were made samples for corrosion tests in order to establish the corrosion rate, corrosion potential and corrosion current in working mediums such as hydrofining oil and industrial water at different temperatures. The corrosion rate values and the temperature influence are important to evaluate joints durability and also the results obtained shows that the boring tube sheet shape with a groove on hole tube shape presents a better corrosion behavior then the shape with smooth hole tube sheet.

Destructive distillation

Energy Technology Data Exchange (ETDEWEB)

Cosden, S; Cosden, J S

1937-09-08

A means and process are described for the destructive distillation of solid carbonaceous materials in which the process comprises charging the material, in a finely divided condition into a stream of hot combustion gases, and allows the hot gases to act pyrolytically on the organic compounds contained in the material, separating the volatile liberated constituents from residuary constituents. Hot reaction gases are generated by fuel ignition means in a generator and are immediately intermingled with comminuted carbonaceous material from a hopper, in a narrow conduit. The mixture of material and reaction fluid is then passed through an elongated confined path, which is exteriorly heated by the combustion chamber of the furnace, where the destructive distillation is effected. Volatile and solid constituents are separated in the chamber, and the volatile constituents are fractionated and condensed.

Tube spacer grid for a heat-exchanger tube bundle

International Nuclear Information System (INIS)

Scheidl, H.

1976-01-01

A tube spacer grid for a heat-exchanger tube bundle is formed by an annular grid frame having a groove formed in its inner surface in which the interspaced grid bars have their ends positioned and held in interspaced relationship by short sections of tubes passed through holes axially formed in the grid frame so that the tubes are positioned between the ends of the grid bars in the grooves. The tube sections may be cut from the same tubes used to form the tube bundle. 5 claims, 3 drawing figures

The Effectiveness of Local Hypothermia and Peritoneal Lavage-Dialysis in the Treatment of Patients with Acute Destructive Pancreatitis

Directory of Open Access Journals (Sweden)

Veniamin I. Shaposhnikov, PhD, ScD

2012-12-01

Full Text Available The aim of this study was to improve the principles of the pathogenetic therapy of acute pancreatitis and assess the effectiveness of local hypothermia of the pancreas, as well as peritoneal lavage-dialysis in the treatment of acute destructive pancreatitis. A total of 5889 patients with acute pancreatitis (AP were examined. The leading role played by the lesions of the pancreatic lymphatic system in the development of destructive processes was noted. In experiments done on eight dogs, the first day of experimental acute pancreatitis showed necrosis of the lumbar retroperitoneal lymph nodes with a violation of lymph drainage from the pancreas before the retroperitoneal fat necrosis was initiated. The effectiveness of local hypothermia of the pancreas was experimentally demonstrated. In 32 patients with AP, the perioperative local hypothermia of the pancreas for 20-25 minutes was followed by the reduction of the alpha-amylase activity in the peripheral blood and in the portal system, as well as a significant reduction in the edema of the pancreas, that delayed the progression of the destructive lesions. An effective method of performing lavage-dialysis of the omental bursa, by using a transversely perforated tube with a pollution control device in the lumen, was developed.

Hysterosalpingographic (HSG pattern of infertility in women of reproductive age

Directory of Open Access Journals (Sweden)

Chinwe R Onwuchekwa

2017-01-01

Full Text Available Background: Infertility is a complex disorder with significant medical, psychological and economic problems. Aims: The aim of the study is to evaluate the structural abnormalities of the uterus and fallopian tubes in infertile women as elucidated by hysterosalpingography. Setting and Design: A retrospective study, conducted at the Radiology and Obstetric and Gynaecologic Departments of a tertiary health care institution. Materials and Methods: Evaluation of all consecutive patients in whom hysterosalpingographic (HSG was performed for infertility between July 2013 and June 2015 in the Department of Radiology. For the biodata, indications for the investigation and the HSG findings were obtained. Statistical Analysis: The data were analyzed using IBM Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA for Windows, version 20 software. Results: A total of 299 patients were evaluated. Of these, 250 were for infertility with primary and secondary infertility constituting 18.4 and 81.6%, respectively. Seventy percent of the cases for infertility had abnormalities on the HSG. Normal uterine cavity was found in 123 (49.2% cases. Uterine filling defects were the most common uterine abnormality. Fallopian tube occlusion, loculated contrast material spillage and hydrosalpinx were more common on the right, and bilateral tubal occlusion was seen only in 11.2%. All cases of intravasation were associated with either unilateral or bilateral fallopian tube blockage or irregularity of the uterus. Conclusion: There was a high incidence of tubal disease in the women presenting with infertility. This was commonly as a result of infection and inflammatory process. This study showed that HSG is very vital in detecting birth canal pathologies; hence, the facility for this important procedure, especially fluoroscopy, should be made available in the health centres for adequate assessment of the women with infertility.

Scintigraphy in the evaluation of disorders of reproductive and sexual function

International Nuclear Information System (INIS)

Zuckier, L.S.

1999-01-01

Nuclear medicine has value in examining functional aspects of reproductive and sexual function, ranging from testicular or cavernosal perfusion in the male, to fallopian tube transport in the female. Blood pool imaging has been helpful in detecting subclinical varicoceles. Proper understanding of the role that these tests play is important for their success and credibility

Scintigraphy in the evaluation of disorders of reproductive and sexual function

Energy Technology Data Exchange (ETDEWEB)

Zuckier, L.S. [Albert Einstein College of Medicine, New York (United States)

1999-09-01

Nuclear medicine has value in examining functional aspects of reproductive and sexual function, ranging from testicular or cavernosal perfusion in the male, to fallopian tube transport in the female. Blood pool imaging has been helpful in detecting subclinical varicoceles. Proper understanding of the role that these tests play is important for their success and credibility.

Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry.

Science.gov (United States)

Marlin, Romain; Nugeyre, Marie-Thérèse; Tchitchek, Nicolas; Parenti, Matteo; Hocini, Hakim; Benjelloun, Fahd; Cannou, Claude; Dereuddre-Bosquet, Nathalie; Levy, Yves; Barré-Sinoussi, Françoise; Scarlatti, Gabriella; Le Grand, Roger; Menu, Elisabeth

2017-09-01

The female reproductive tract (FRT) is one of the major mucosal invasion sites for HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the FRT after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized specific immune responses in all compartments of the FRT of nonhuman primates after systemic vaccination. Memory T cells were preferentially found in the lower tract (vagina and cervix), whereas APCs and innate lymphoid cells were mainly located in the upper tract (uterus and fallopian tubes). This compartmentalization of immune cells in the FRT was supported by transcriptomic analyses and a correlation network. Polyfunctional MVA-specific CD8 + T cells were detected in the blood, lymph nodes, vagina, cervix, uterus, and fallopian tubes. Anti-MVA IgG and IgA were detected in cervicovaginal fluid after a second vaccine dose. Thus, systemic vaccination with an MVA vector elicits cellular and Ab responses in the FRT. Copyright © 2017 by The American Association of Immunologists, Inc.

Overview of steam generator tube-inspection technology

Energy Technology Data Exchange (ETDEWEB)

Obrutsky, L.; Renaud, J.; Lakhan, R., E-mail: obrutskl@aecl.ca, E-mail: renaudj@aecl.ca, E-mail: lakhanr@aecl.ca [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)

2014-03-15

Degradation of steam generator (SG) tubing due to both mechanical and corrosion modes has resulted in extensive repairs and replacement of SGs around the world. The variety of degradation modes challenges the integrity of SG tubing and, therefore, the stations' reliability. Inspection and monitoring aimed at timely detection and characterization of the degradation is a key element for ensuring tube integrity. Up to the early-70's, the in-service inspection of SG tubing was carried out using single-frequency eddy current testing (ET) bobbin coils, which were adequate for the detection of volumetric degradation. By the mid-80's, additional modes of degradation such as pitting, intergranular attack, and axial and circumferential inside or outside diameter stress corrosion cracking had to be addressed. The need for timely, fast detection and characterization of these diverse modes of degradation motivated the development in the 90's of inspection systems based on advanced probe technology coupled with versatile instruments operated by fast computers and remote communication systems. SG inspection systems have progressed in the new millennium to a much higher level of automation, efficiency and reliability. Also, the role of Non Destructive Evaluation (NDE) has evolved from simple detection tools to diagnostic tools that provide input into integrity assessment decisions, fitness-far-service and operational assessments. This new role was motivated by tighter regulatory requirements to assure the safety of the public and the environment, better SG life management strategies and often self-imposed regulations. It led to the development of advanced probe technologies, more reliable and versatile instruments and robotics, better training and qualification of personnel and better data management and analysis systems. This paper provides a brief historical perspective regarding the evolution of SG inspections and analyzes the motivations behind that

Quality evaluation of soil-cement-plant residue bricks by the combination of destructive and non-destructive tests

Directory of Open Access Journals (Sweden)

Regis de C. Ferreira

Full Text Available ABSTRACT Residues from agricultural activity can be used to improve the quality of soil-based bricks, constituting an interesting alternative for their destination. The technical quality of soil-cement-plant residue bricks was evaluated by the combination of non-destructive and destructive methods. A predominant clayey soil, Portland cement and residues of husks of both rice and Brachiaria brizantha cv. Marandu (0, 10, 20, 30 and 40%, in mass, in substitution to the 10% cement content were used. The bricks were submitted to destructive (water absorption and compressive strength and nondestructive (ultrasound tests for their physical and mechanical characterization. Results from both destructive and non-destructive tests were combined to determine the quantitative parameter named “anisotropic resistance” in order to evaluate the quality of the bricks. The addition that promoted best technical quality was 10% residue content, regardless of the residue type. The anisotropic resistance proved to be adequate for the technical quality evaluation of the bricks.

Innovation in Non Destructive Testing

NARCIS (Netherlands)

Wassink, C.H.P.

2012-01-01

In many established companies the pace of innovation is low. The Non-Destructive Testing sector is an example of a sector where the pace of innovation is very slow. Non-Destructive Testing (NDT) refers to the set of non-invasive activities used to determine the condition of objects or installations

Destructive distillation; retorts

Energy Technology Data Exchange (ETDEWEB)

Beilby, G T

1881-10-03

For distilling shale and other oil-yielding minerals. Relates to apparatus described in Specification No. 2169 (1881) in which retorts arranged in sets, and mounted loosely in brickwork to allow expansion, are formed preferably of upper iron tubes, fixed by socket rings, to lower fireclay tubes formed with belts which, together with ledges in the sides of the oven, support fireclay slabs. In some cases the lower parts of the retorts may be formed of iron tubes. Each set of four upper tubes is supplied with a four-way hopper, suspended by means of a pair of counter-weighted levers, centered on bearing plates and connected with the hopper by links. A single pipe connected to the hopper serves for leading off the vapors from the four retorts. The retorts are heated by a furnace, the hot gases from which after acting on the retorts are led to ovens in which are placed steam generators and superheaters, from which steam is conveyed to the interior of the retorts to assist the decomposition.

Sonographic assessment of pregnancy co-existing with uterine ...

African Journals Online (AJOL)

EB

but the fibroids are usually innocent bystanders.4 They cause only 2% to 3% of cases of infertility. Fibroids that block one or both of the fallopian tubes may prevent sperm from fertilizing an egg while fibroids that fill the uterine cavity may block implantation of a newly fertilized egg.5. Based on risk factors for myoma ...

Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer

Science.gov (United States)

2015-10-08

Anxiety Disorder; Depression; Fatigue; Leydig Cell Tumor; Ovarian Sarcoma; Ovarian Stromal Cancer; Pain; Peritoneal Carcinomatosis; Pseudomyxoma Peritonei; Recurrent Breast Cancer; Recurrent Cervical Cancer; Recurrent Endometrial Carcinoma; Recurrent Fallopian Tube Cancer; Recurrent Gestational Trophoblastic Tumor; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Primary Peritoneal Cavity Cancer; Recurrent Uterine Sarcoma; Recurrent Vaginal Cancer; Recurrent Vulvar Cancer

The scope of nonsuicidal self-injury on YouTube.

Science.gov (United States)

Lewis, Stephen P; Heath, Nancy L; St Denis, Jill M; Noble, Rick

2011-03-01

Nonsuicidal self-injury, the deliberate destruction of one's body tissue (eg, self-cutting, burning) without suicidal intent, has consistent rates ranging from 14% to 24% among youth and young adults. With more youth using video-sharing Web sites (eg, YouTube), this study examined the accessibility and scope of nonsuicidal self-injury videos online. Using YouTube's search engine (and the following key words: "self-injury" and "self-harm"), the 50 most viewed character (ie, with a live individual) and noncharacter videos (100 total) were selected and examined across key quantitative and qualitative variables. The top 100 videos analyzed were viewed over 2 million times, and most (80%) were accessible to a general audience. Viewers rated the videos positively (M = 4.61; SD: 0.61 out of 5.0) and selected videos as a favorite over 12 000 times. The videos' tones were largely factual or educational (53%) or melancholic (51%). Explicit imagery of self-injury was common. Specifically, 90% of noncharacter videos had nonsuicidal self-injury photographs, whereas 28% of character videos had in-action nonsuicidal self-injury. For both, cutting was the most common method. Many videos (58%) do not warn about this content. The nature of nonsuicidal self-injury videos on YouTube may foster normalization of nonsuicidal self-injury and may reinforce the behavior through regular viewing of nonsuicidal self-injury-themed videos. Graphic videos showing nonsuicidal self-injury are frequently accessed and received positively by viewers. These videos largely provide nonsuicidal self-injury information and/or express a hopeless or melancholic message. Professionals working with youth and young adults who enact nonsuicidal self-injury need to be aware of the scope and nature of nonsuicidal self-injury on YouTube.

Structural integrity assessments of steam generator tubes using the FAD methodology

Energy Technology Data Exchange (ETDEWEB)

Bergant, Marcos A., E-mail: marcos.bergant@cab.cnea.gov.ar [Gerencia CAREM, Centro Atómico Bariloche (CNEA), Av. Bustillo 9500, San Carlos de Bariloche 8400 (Argentina); Yawny, Alejandro A., E-mail: yawny@cab.cnea.gov.ar [División Física de Metales, Centro Atómico Bariloche (CNEA)/CONICET, Av. Bustillo 9500, San Carlos de Bariloche 8400 (Argentina); Perez Ipiña, Juan E., E-mail: juan.perezipina@fain.uncoma.edu.ar [Grupo Mecánica de Fractura, Universidad Nacional del Comahue/CONICET, Buenos Aires 1400, Neuquén 8300 (Argentina)

2015-12-15

Highlights: • The Failure Assessment Diagram (FAD) is used to assess cracked steam generator tubes. • Typical loading conditions and reported tensile and fracture properties are used. • The FAD is capable to predict the failure mode for different cracks and loads. • The FAD can be used to reduce the conservatism of the current plugging criteria. • Appropriate tensile and fracture properties at operating conditions are required. - Abstract: Steam generator tubes (SGTs) represents up to 60% of the total primary pressure retaining boundary area of a nuclear power plant. They have been found susceptible to diverse degradation mechanisms during service. Due to the significance of a SGT failure on the plant safe operation, nuclear regulatory authorities have established tube plugging or repairing criteria which are based on the defect depth. The widespreadly used “40% criterion” proposed in the 70s is an example whose use is still recommended in the last editions of the ASME Boiler and Pressure Vessel Code. In the present work, an alternative, more realistic and less conservative methodology for SGT integrity evaluation is proposed. It is based on the Failure Assessment Diagram (FAD) and takes advantage of the recent developments in non-destructive techniques which allow a more comprehensive characterization of tube defects, i.e., depth, length, orientation and type. The proposed approach has been applied to: the study of the influence of primary and secondary stresses on tube integrity; the prediction of failure mode (i.e., ductile fracture or plastic collapse) of defective SGTs for varied crack geometries and loading conditions; the analysis of the sensibility of tensile and fracture properties with temperature. The potentiality of the FAD as a comprehensive methodology for predicting the failure loads and failure modes of flawed SGTs is highlighted.

Structural integrity assessments of steam generator tubes using the FAD methodology

International Nuclear Information System (INIS)

Bergant, Marcos A.; Yawny, Alejandro A.; Perez Ipiña, Juan E.

2015-01-01

Highlights: • The Failure Assessment Diagram (FAD) is used to assess cracked steam generator tubes. • Typical loading conditions and reported tensile and fracture properties are used. • The FAD is capable to predict the failure mode for different cracks and loads. • The FAD can be used to reduce the conservatism of the current plugging criteria. • Appropriate tensile and fracture properties at operating conditions are required. - Abstract: Steam generator tubes (SGTs) represents up to 60% of the total primary pressure retaining boundary area of a nuclear power plant. They have been found susceptible to diverse degradation mechanisms during service. Due to the significance of a SGT failure on the plant safe operation, nuclear regulatory authorities have established tube plugging or repairing criteria which are based on the defect depth. The widespreadly used “40% criterion” proposed in the 70s is an example whose use is still recommended in the last editions of the ASME Boiler and Pressure Vessel Code. In the present work, an alternative, more realistic and less conservative methodology for SGT integrity evaluation is proposed. It is based on the Failure Assessment Diagram (FAD) and takes advantage of the recent developments in non-destructive techniques which allow a more comprehensive characterization of tube defects, i.e., depth, length, orientation and type. The proposed approach has been applied to: the study of the influence of primary and secondary stresses on tube integrity; the prediction of failure mode (i.e., ductile fracture or plastic collapse) of defective SGTs for varied crack geometries and loading conditions; the analysis of the sensibility of tensile and fracture properties with temperature. The potentiality of the FAD as a comprehensive methodology for predicting the failure loads and failure modes of flawed SGTs is highlighted.

DESTRUCTIVE EDUCATIONAL PRACTICES AT UNIVERSITY

Directory of Open Access Journals (Sweden)

Андрей Владимирович Феоктистов

2013-05-01

Full Text Available The article is devoted to problems of origin and development of destructive educational practices at university. The authors focus on complex of interactions that disturb the existing in the academic environment norms and ethical principles. The most vivid evidence of destructive educational practice is the corruption issue. On the basis of the analyzed publications dealing with dynamics of corruption in the Russian higher education and the results of the survey by questionnaire, carried out at the technical university, the complex of recommendations has been prepared and suggested that is directed at minimization of destructive behavior at university.DOI: http://dx.doi.org/10.12731/2218-7405-2013-4-28

Size determinations, by ultrasonic techniques, of cracks in hydride blisters formed in Zr-2.5 % Nb pressure tubes

International Nuclear Information System (INIS)

Trujillo Badillo, Giovanna; Desimone, Carlos; Domizzi, Gladys

1999-01-01

Non destructive techniques (NDT) are very useful in the detection of flaws produced in structural components in service. During the service of CANDU nuclear power reactors, it is possible that pressure tubes (PT) may contact calandria tubes (CT). After the PT/CT contact, zirconium hydride blisters may form at the point of contact depending on the concentration of hydrogen/deuterium. Zirconium hydride is brittle and is therefore prone to cracking under stress. Ultrasonic NDT is routinely use during PT in service inspection. In order to be able of detecting cracked blisters, it is of great importance the development of standards to calibrate the employed equipment. On this purpose, hydride blisters were grown, in laboratory, on sections of pressure tube. The cracks in the blisters were detected and measured by ultrasonic techniques. The obtained results were compared with measurements carried out in optic microscope, on successive sections of the samples. The crack tip diffraction technique was found to be the more effective for the mentioned ends. (author)

Stress identification in steam generator tubes from profile measurements

International Nuclear Information System (INIS)

Andrieux, S.; Voldoire, F.

1993-01-01

An identification method devoted to the determination of stresses in tubes, by means of profile measurements, provided by on site non-destructive evaluations, is presented here. From the only available data (the radial displacement w on the inner wall), the computation of the strains, and consequently the stresses in the elastoplastic range, is made within the framework of the shell theory. For this purpose, we need to determine the associated curvature w'': this step is an ill-posed problem, because of the lack of continuity with respect to the discrete data. This difficulty is overridden by means of an appropriate regularization procedure. The predictive ability of the method has been tested by comparison with direct simulations; we present an industrial application. (author)

Money Creation and Destruction

OpenAIRE

Faure, Salomon; Gersbach, Hans

2017-01-01

We study money creation and destruction in today’s monetary architecture and examine the impact of monetary policy and capital regulation in a general equilibrium setting. There are two types of money created and destructed: bank deposits, when banks grant loans to firms or to other banks and central bank money, when the central bank grants loans to private banks. We show that equilibria yield the first-best level of money creation and lending when prices are flexible, regardless of the monet...

Tube holding system

International Nuclear Information System (INIS)

Cunningham, R.C.

1978-01-01

A tube holding rig is described for the lateral support of tubes arranged in tight parcels in a heat exchanger. This tube holding rig includes not less than two tube supporting assemblies, with a space between them, located crosswise with respect to the tubes, each supporting assembly comprising a first set of parallel components in contact with the tubes, whilst a second set of components is also in contact with the tubes. These two sets of parts together define apertures through which the tubes pass [fr

Non-destructive and destructive examination of the retired North Anna 2 Reactor Pressure Vessel Head

International Nuclear Information System (INIS)

Ahluwalia, Kawaljit; Barnes, Robert; Rao, Gutti; Cattant, Francois; Peat, Noel

2006-09-01

Stress corrosion cracking of Alloy 600 and nickel-based weld materials has been the single biggest challenge facing the PWR industry. A fundamental and thorough knowledge was needed to properly explain this phenomenon and develop appropriate mitigation strategies. Non Destructive Examination (NDE) of the North Anna Unit 2 Reactor Vessel Head (RVH) during the 2002 fall outage identified widespread crack indications in the Alloy 600 CRDM penetrations and associated Alloy 182 and 82 J-groove attachment welds. When the Utility decided to replace the RVH, a rare opportunity was provided to the industry to undertake in-depth studies of representative defective CRDM penetrations from a retired RVH. Accordingly, the Materials Reliability Program, undertook a two-phase program on the retired North Anna 2 Alloy 600 RVH. The first phase involved selection and removal of six penetrations from the RVH and penetration decontamination, replication and laboratory NDE. The second phase consisted of a detailed destructive examination of penetration number 54. This paper provides a summary of work undertaken during this program. Criteria for selection of penetrations for removal and procedures used in removal of the penetrations are described. Extreme care was undertaken in decontamination of the penetrations to facilitate laboratory NDE. Penetration number 54 was then subjected to destructive examination to establish a correlation between NDE findings (from both field and laboratory inspections) and actual flaws. Additional objectives of the destructive examination included mechanistic assessment of defect formation and investigation of the annulus environment and wastage characterization. Data obtained from these studies is invaluable in validating safety assessment statements by developing the correlation between field NDE and actual defects. In addition, information gathered from non-destructive and destructive examinations is used to assess accuracy of the NDE techniques

HF electronic tubes. Technologies, grid tubes and klystrons

International Nuclear Information System (INIS)

Lemoine, Th.

2009-01-01

This article gives an overview of the basic technologies of electronic tubes: cathodes, electronic optics, vacuum and high voltage. Then the grid tubes, klystrons and inductive output tubes (IOT) are introduced. Content: 1 - context and classification; 2 - electronic tube technologies: cathodes, electronic optics, magnetic confinement (linear tubes), periodic permanent magnet (PPM) focussing, collectors, depressed collectors; 3 - vacuum technologies: vacuum quality, surface effects and interaction with electrostatic and RF fields, secondary emission, multipactor effect, thermo-electronic emission; 4 - grid tubes: operation of a triode, tetrodes, dynamic operation and classes of use, 'common grid' and 'common cathode' operation, ranges of utilisation and limitations, operation of a tetrode on unadjusted load, lifetime of a tetrode, uses of grid tubes; 5 - klystrons: operation, impact of space charge, multi-cavity klystrons, interaction efficiency, extended interaction klystrons, relation between interaction efficiency, perveance and efficiency, ranges of utilization and power limitations, multi-beam klystrons and sheet beam klystrons, operation on unadjusted load, klystron band pass and lifetime, uses; 6 - IOT: principle of operation, ranges of utilisation and limitations, interaction efficiency and depressed collector IOT, IOT lifetime and uses. (J.S.)

Intercomparison of techniques for inspection and diagnostics of heavy water reactor pressure tubes. Determination of hydrogen concentration and blister characterization

International Nuclear Information System (INIS)

2009-03-01

Heavy water reactors (HWRs) comprise significant numbers of today's operating nuclear power plants, and more are under construction. Efficient and accurate inspection and diagnostic techniques for various reactor components and systems, especially pressure tubes, are an important factor in ensuring reliable and safe plant operation. To foster international collaboration in the efficient and safe use of nuclear power, the IAEA conducted a Coordinated Research Project (CRP) on Intercomparison of Techniques for HWR Pressure Tube Inspection and Diagnostics. This CRP was carried out within the framework of the IAEA's Technical Working Group on Advanced Technologies for HWRs (the TWG-HWR). The TWG-HWR is a group of experts nominated by their governments and designated by the IAEA to provide advice and to support implementation of IAEA's project on advanced technologies for HWRs. The objective of the CRP was to compare non-destructive inspection and diagnostic techniques, in use and being developed, for structural integrity assessment of HWR pressure tubes. During the first phase of this CRP participants investigated the capability of different techniques to detect and characterize flaws. During the second phase participants collaborated to detect and characterize hydride blisters and to determine the hydrogen concentration in zirconium alloys. The intention was to identify the most effective pressure tube inspection and diagnostic methods and to identify further development needs. The organizations which participated in phase 2 of this CRP are: - Comision Nacional de Energia Atomica (CNEA), Argentina; - Atomic Energy of Canada Ltd. (AECL), Chalk River Laboratories (CRL), Canada; - Bhabha Atomic Research Centre (BARC), India; - Korea Atomic Energy Research Institute (KAERI), Republic of Korea; - National Institute for Research and Development for Technical Physics (NIRDTP), Romania; - Nuclear Non-Destructive Testing Research and Services (NNDT), Romania. IAEA-TECDOC-1499

Collision-induced destructive quantum interference

International Nuclear Information System (INIS)

Yang Xihua; Sun Zhenrong; Zhang Shi'an; Ding Liang'en; Wang Zugeng

2005-01-01

We conduct theoretical studies on the collision-induced destructive quantum interference of two-colour two-photon transitions in an open rhomb-type five-level system with a widely separated doublet by the density matrix approach. The effects of the collision-induced decay rates, the ratio of the transition dipole moments and the energy separation of the doublet on the interference are analysed. It is shown that a narrow dip appears in the excitation spectrum due to the collision-induced destructive interference, and that the narrow interference dip still exists even when the collision broadening is comparable to the energy separation of the doublet. The physical origin of the collision-induced destructive quantum interference is analysed in the dressed-atom picture

State-of-the-art review of OPG steam generator tubing degradation mechanisms

International Nuclear Information System (INIS)

Brennenstuhl, A.M.; Ramamurthy, S.; Good, G.M.

2009-01-01

Steam generator (SG) degradation has been a major cause of pressurized water reactor (PWR) incapability world-wide and has limited the useful life of SGs at some utilities. The vast majority of the degradation has been the result of SCC of the thin walled nickel alloy SG tubes and has been most prevalent in mill annealed (MA) Alloy 600. Fortunately, Ontario Power Generation (OPG) SG tubes are manufactured from alloys that have much better resistance to this form of localized corrosion than Alloy 600MA and as a consequence have not encountered SCC to date. Other forms of degradation nevertheless have been experienced; some units at Pickering - B in particular have had many Alloy 400 SG tubes removed from service due to severe underdeposit corrosion (UDC) and costly modifications have been made to Darlington SGs to prevent leaks as a result of SG tube fretting-wear at tube supports. Degradation other than UDC and fretting-wear which could pose a threat to the future reliable operation of OPG's nuclear fleet has also been observed. Important activities in effectively managing SG degradation include determining the mode of degradation and arriving at an understanding of the contributing factors. This is done by a combination of non-destructive examination (NDE) of SG tubing in-situ, SG tube removals for metallurgical examination and research and development. SG tube metallurgical examinations provide information that can be used in the timely development of a strategy dealing with the degradation in the short to intermediate timeframe. Determining the main causative factors at a mechanistic level helps to improve the predictive capability and increases the probability of dealing with the problem in the most cost-effective way. OPG has used this approach together with in-situ NDE inspections during planned outages of its nuclear reactors to minimize the possibility of unscheduled outages and provide the best possible fitness-for-service assessments. Many metallurgical

Tube to tube excursive instability - sensitivities and transients

International Nuclear Information System (INIS)

Brown, M.; Layland, M.W.

1980-01-01

A simple basic analysis of excursive instability in a boiler tube shows how it depends upon operating conditions and physical properties. A detailed mathematical model of an AGR boiler is used to conduct a steady state parameter sensitivity survey. It is possible from this basis to anticipate the effects of changes in operating conditions and changes in design parameters upon tube to tube stability. Dynamic responses of tubes operating near the stability threshold are examined using a mathematical model. Simulated excursions are triggered by imparting small abrupt pressure changes on the boiler inlet pressure. The influences of the magnitude of the pressure change, waterside friction factor and gas side coupling between tubes are examined. (author)

Condenser tube buckling within tube-tubesheet joints

International Nuclear Information System (INIS)

Willertz, L.E.; Kalnins, A.; Updike, D.P.

1991-01-01

The problem of the appearance of protrusions, or bumps, in the interior of roller-expanded tubes within a tubesheet is addressed. Such bumps have been observed in condensers of power plants. A brief history of the reported occurrences of the bumps is given. The hypothesis is advanced that the mechanics of the formation of the bumps is similar to a buckling problem that has 'bifurcation at infinity'. Following this hypothesis, a two-dimensional physical model is developed, and the application of this model to study a three-dimensional bump is proposed. It is proposed in this paper that an initial deviation from the circular shape of the tube required to produce a bump. It is shown that without such a deviation the tubes cannot buckle. An experiment with short tube segments has been performed that verifies some of the features of the observed condenser tube bumps. Exactly what force produced the initial deviation for the observed bumps is still unknown. Available evidence implicates the hydro-laser jet that is used in the cleaning of tubes and tubesheets. A scenario of how a bump could have been produced by the hydro-laser jet is proposed. (author)

Collisional destruction of fast hydrogen Rydberg atoms

International Nuclear Information System (INIS)

King, M.R.

1984-01-01

A new modulated electric field technique was developed to study Rydberg atom destruction processes in a fast beam. The process of destruction of a band of Rydberg atom destruction of a band of Rydberg atoms through the combined processes of ionization, excitation, and deexcitation was studied for collisions with gas targets. Rydberg atoms of hydrogen were formed by electron capture, and detected by field ionization. The modulated field technique described proved to be an effective technique for producing a large signal for accurate cross section measurements. The independent particle model for Rydberg atom destruction processes was found to hold well for collisions with molecular nitrogen, argon, and carbon dioxide. The resonances in the cross sections for the free electron scattering with these targets were found to also occur in Rydberg destruction. Suggestions for future investigations of Rydberg atom collision processes in the fast beam regime are given

Destructive distillation

Energy Technology Data Exchange (ETDEWEB)

Allison, C A

1906-05-22

The invention relates to an apparatus in which the destructive distillation or coking of coal, peat, shale, etc., is carried out by means of a current of hot gases at a temperature of 700--800/sup 0/F., as described in Specification No. 11,925, A.D. 1906.

Verification of Chemical Weapons Destruction

International Nuclear Information System (INIS)

Lodding, J.

2010-01-01

The Chemical Weapons Convention is the only multilateral treaty that bans completely an entire category of weapons of mass destruction under international verification arrangements. Possessor States, i.e. those that have chemical weapons stockpiles at the time of becoming party to the CWC, commit to destroying these. All States undertake never to acquire chemical weapons and not to help other States acquire such weapons. The CWC foresees time-bound chemical disarmament. The deadlines for destruction for early entrants to the CWC are provided in the treaty. For late entrants, the Conference of States Parties intervenes to set destruction deadlines. One of the unique features of the CWC is thus the regime for verifying destruction of chemical weapons. But how can you design a system for verification at military sites, while protecting military restricted information? What degree of assurance is considered sufficient in such circumstances? How do you divide the verification costs? How do you deal with production capability and initial declarations of existing stockpiles? The founders of the CWC had to address these and other challenges in designing the treaty. Further refinement of the verification system has followed since the treaty opened for signature in 1993 and since inspection work was initiated following entry-into-force of the treaty in 1997. Most of this work concerns destruction at the two large possessor States, Russia and the United States. Perhaps some of the lessons learned from the OPCW experience may be instructive in a future verification regime for nuclear weapons. (author)

Non-destructive controls

International Nuclear Information System (INIS)

Nouvet, A.

1978-01-01

The non-destructive controls permit, while respecting their integrity, the direct and individual examination of parts or complete objects as they are manufactured, as well as to follow the evolution of their eventual defects while in operation. The choice of control methods depends on the manufacturing process and shapes of parts, on the physical properties of their components as well as the nature, position and size of the defects which are likely to be detected. Whether it is a question of controls by means of ionizing radiation, flux of neutrons, ultrasons, acoustic source, sweating, magnetoscopy. Foucault currents, thermography, detection of leaks or non-destructive metallography, each has a limited field of application such that they are less competitive than complementary [fr

On guided circumferential waves in soft electroactive tubes under radially inhomogeneous biasing fields

Science.gov (United States)

Wu, Bin; Su, Yipin; Chen, Weiqiu; Zhang, Chuanzeng

2017-02-01

elastic waves for the ultrasonic non-destructive online SHM to detect interior structural defects or fatigue cracks and for the self-sensing of the actual state of the soft EA tube actuator.

The forms of destructive behavior in the workplace

Directory of Open Access Journals (Sweden)

D A Narozhnaia

2015-12-01

Full Text Available Personnel have become a key resource of organizations in the contemporary society for the way personnel fulfills its work functions can provide important advantages in the competitive market. However, despite the fact that organizations’ management pays great attention to the development of the constructive forms of work behavior, various forms of destructive behavior in the workplace are quite widespread nowadays. The author uses the concept “destructive labor behavior” to denote such observable actions of employees that hinder achieving organizations’ aims and entail negative consequences. The article analyzes relationships between concepts “destructive labor behavior”, “social behavior” and “organizational behavior”; identifies the most common types of destructive labor behavior, such as absenteeism, theft, sabotage, lowered labor activity, and their key features; considers their negative consequences, such as decreased production, decline in the quality of products or services, conflicts in the team, tensions between workers and employers; analyzes different classifications of the destructive forms of labor behavior. The author concludes that we need a general classification of the destructive forms of labor behavior based on their grouping on three grounds: the essence of the negative consequences of the destructive behavior; the violated legal norms; the causes of the destructive behavior. Moreover, the article identifies three groups of organizational factors that can generate destructive forms of labor behavior - production factors (content, organization and conditions of work, social factors (group relations and psychological (personal characteristics of employees - and provides recommendations to reduce their impact on the organization.

7 CFR 160.9 - Destructively distilled wood turpentine.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Destructively distilled wood turpentine. 160.9 Section... REGULATIONS AND STANDARDS FOR NAVAL STORES General § 160.9 Destructively distilled wood turpentine. The designation “destructively distilled wood turpentine” shall refer to the kind of spirits of turpentine...

Chest tube insertion

Science.gov (United States)

Chest drainage tube insertion; Insertion of tube into chest; Tube thoracostomy; Pericardial drain ... Be careful there are no kinks in your tube. The drainage system should always sit upright and be placed ...

Vibro-impact responses of a tube with tube--baffle interaction

International Nuclear Information System (INIS)

Shin, Y.S.; Sass, D.E.; Jendrzejczyk, J.A.

1978-01-01

The relatively small, inherent tube-to-baffle hole clearances associated with manufacturing tolerances in heat exchangers affect the vibrational characteristics and the response of the tube. Numerical studies were made to predict the vibro-impact response of a tube with tube-baffle interaction. The finite element method has been employed with a non-linear elastic contact spring-dashpot to model the effect of the relative approach between the tube and the baffle plate. The coupled equations of motion are directly integrated with a proportional system damping represented by a linear combination of mass and stiffness. Lumped mass approach with explicit time integration scheme was found to be a suitable choice for tube-baffle impacting analysis. Fourier analyses indicate that the higher mode contributions to the tube response are significant for strong tube-baffle impacting. The contact damping forces are negligible compared with the contact spring forces. The numerical analysis results are in reasonably good agreement with those of the experiments

Residual stresses in a composite steel tube measured by neutron diffraction

International Nuclear Information System (INIS)

Taran, Yu.V.; Balagurov, A.M.; Zlokazov, V.B.; Schreiber, J.; Stuhr, U.; Kockelmann, H.

2006-01-01

The triaxial residual stresses in a composite tube from an austenitic stainless steel with a welded ferritic steel cladding were measured by the time-of-flight neutron diffraction method on the POLDI instrument at the PSI SINQ facility. The POLDI results are compared to the results obtained by the destructive turning out method and theoretical predictions of calculations by the finite element method. Only for the tangential component of the stress tensor the semiquantitative agreement of all used methods was observed. There is a clear discrepancy between the results of the different methods in the axial component. For the radial component all methods reveal quite small stresses, however, with some distinct differences in their distributions

[Comparison of diagnostic quality in hysterosalpingography between iodinated non-ionic contrast media with low and high osmolarity].

Science.gov (United States)

Piccotti, K; Guida, D; Carbonetti, F; Stefanetti, L; Macioce, A; Cremona, A; David, V

Comparison of diagnostic quality in hysterosalpingography between low and high-osmolality contrast media. We performed a retrospective evaluation of two cohorts of patients who underwent HSG using contrast media with different osmolarity: the first group ,47 patients, underwent hysterosalpingography in the period September 2011-December 2012 using Iopromide 370 mg/ml; the second group, 50 patients, underwent HSG from January 2013 to October 2013 using Iomeprol 400 mg/ml. Three radiologists, in consensus reading,, reviewed the radiographs by assessing the following four parameters: opacification of the uterine cavity, uterine profiles definition, Fallopian tubes visualization, contrast media spillage into peritoneum. A score-scale from 0 to 3 was assigned for each of the mentioned parameter (0 = minimum non-diagnostic exam, 1 = sufficient examination; 2 = good quality examination; maximum 3 = high quality images). We documented a statistically significant higher quality in displaying Fallopian tubes among patients studied through high osmolarity contrast medium (Iopromide 370 mg/ml) than what obtained through lower osmolarity contrast medium (Iomeprol 400 mg/ml). The use of high osmolarity contrast medium enabled better visualization of the tubes and a greater number of diagnoses of chronic aspecific salpigintis due to the increased osmolality and viscosity of Iomeprol 400 mg/ml. There were no significant differences between the two contrast agents in the evaluation of intra-uterine pathology and in the evaluation of the tubal patency.

Electrochemical destruction of nitrosamines

Energy Technology Data Exchange (ETDEWEB)

Lejen, T; Volchek, K; Ladanowski, C; Velicogna, D; Whittaker, H [Environment Canada, Ottawa, ON (Canada). Emergencies Engineering Div.

1996-09-01

Treatment conditions for the electrolytic destruction of nitrosamines were studied. The joint investigation between Canada and the Ukraine was part of an assessment of hazardous contaminants at former Soviet ICBM missile sites. The electrochemical destruction of N-dimethylnitrosamines (NDMA) on carbon/platinum electrodes was studied under basic and acidic conditions by UV spectroscopy, gas chromatography, mass spectroscopy, and colorimetry. Experiments with a 100 ppm NDMA solution showed that electrolytic-reduction was pH sensitive within a range of pH 0.5 to 4.0. Electrolysis was effective for the reduction of NDMA in strong acidic conditions. 30 refs., 1 tab., 4 figs.

Facing towards or Turning away from Destructive Narcissism

Science.gov (United States)

Flynn, Denis; Skogstad, Helga

2006-01-01

This paper presents a detailed theoretical discussion of destructive narcissism in relation to Freud and Rosenfeld and later theorists. In destructive narcissism, the destructiveness is itself idealised and overrides "the vital functions which serve the purpose of self-preservation" (Freud, S., 1914, "On narcissism" S.E. 14: 87)--a feature which…

Can non-destructive inspection be reliable

International Nuclear Information System (INIS)

Silk, M.G.; Stoneham, A.M.; Temple, J.A.G.

1988-01-01

The paper on inspection is based on the book ''The reliability of non-destructive inspection: assessing the assessment of structures under stress'' by the present authors (published by Adam Hilger 1987). Emphasis is placed on the reliability of inspection and whether cracks in welds or flaws in components can be detected. The need for non-destructive testing and the historical attitudes to non-destructive testing are outlined, along with the case of failure. Factors influencing reliable inspection are discussed, and defect detection trials involving round robin tests are described. The development of reliable inspection techniques and the costs of reliability and unreliability are also examined. (U.K.)

Destruction as a Step in Heidegger's Phenomenology

Directory of Open Access Journals (Sweden)

M.J Safian

2014-08-01

Full Text Available One of the most controversial issues in Heidegger’s philosophy is his claim that western philosophy tradition has overlooked the issue of Being. Heidegger’s attempt is to reveal the origins of this negligence by means of destruction. However, it seems that through such claim Heidegger aims to destroy and disvalue this tradition. In addition to defining and explaining destruction, our purpose in this article is to show that Heidegger’s goal is not to destroy the tradition of philosophy but the term destruction refers to a process which is a step in Heidegger’s phenomenology by means of which one can conceive and perceive Being better because only through such destruction ontology can fully assure itself in a phenomenological way of the genuine character of its concepts. The necessity of doing destruction in Heidegger’s thought has also been discussed and his persistence on it has been shown in two of his works, one belongs to early and another to later Heidegger.

Secondary side corrosion in steam generator tubes: lessons learned in France from the in-service inspection results

International Nuclear Information System (INIS)

Comby, R.

1997-01-01

Non-destructive testing (NDT) has proved to be very important in the maintenance of steam generator tubing. This is particularly true in the case of secondary side corrosion, because this type of degradation leads to various morphologies which are often complex (intergranular attack) (IGA), intergranular stress corrosion cracking (IGSCC), or a mixture of both. Their detection and characterization by the usual NDT techniques have been achieved through numerous laboratory studies, which were conducted in order to determine the performance and limitations of NDT. Pulled tube examination in a hot laboratory was very valuable, for both NDT and fracture mechanics aspects. The eddy current bobbin coil probe, used for multipurpose inspection of tubes, allows the detection of IGA-SCC at the tube support plate elevation. In France, the use of rotating probes is not required for that type of degradation, since the repair criterion is based on bobbin coil results only. The bobbin coil is also used for detection of IGSCC occurring in free spans, within sludge deposits. The eddy current rotating probe allows, in that case, characterization of main cracks. Concerning the outer diameter initiated circumferential cracks which occur at the top of the tube sheet, only the rotating probe is used. An ultrasonic (UT) inspection was performed several times, in order to obtain information on UT capabilities. The goal of tube inspection is obviously knowledge of the status of steam generators, but also to follow up degradations and to estimate their revolution, and to verify the beneficial effect of some corrective measures, e.g. boric acid injection. (orig.)

Laparoscopic evaluation of tubal pathology in cases of infertility

Directory of Open Access Journals (Sweden)

Maherunnessa

2013-07-01

Full Text Available Infertility is a public health problem in developed and developing countries. Diagnostic laparoscopy is a generally accepted procedure to detect pelvic organ pathologies affecting fertility. This study was undertaken to find out the tubal pathology contributing to primary and secondary infertility by laparoscopic examination. The study was carried out in the department of Gynaecology and Obstetrics, BIRDEM during the period of January 2001 to December 2001. The study group comprised of 100 cases of infertile patients of age between 20 to 40 years. Sixty seven percent patients had primary infertility and 33% patients had secondary infertility. Size and shape of the uterus was normal in 69% cases and bicornuate uterus was found in 2% cases. Out of total cases, 71% and 69% had normal right and left fallopian tubes respectively. Patency of right and left fallopian tube was normal in 90% and 89% cases respectively while 11% and 10% had peritubal adhesions. Laparoscopy examination is an important tool for evaluation of tubal pathology contributing to infertility and might play a major role in infertility management. Ibrahim Med. Coll. J. 2013; 7(2: 38-40

Pressure tube reactor

International Nuclear Information System (INIS)

Susuki, Akira; Murata, Shigeto; Minato, Akihiko.

1993-01-01

In a pressure tube reactor, a reactor core is constituted by arranging more than two units of a minimum unit combination of a moderator sealing pipe containing a calandria tube having moderators there between and a calandria tube and moderators. The upper header and a lower header of the calandria tank containing moderators are communicated by way of the moderator sealing tube. Further, a gravitationally dropping mechanism is disposed for injecting neutron absorbing liquid to a calandria gas injection portion. A ratio between a moderator volume and a fuel volume is defined as a function of the inner diameter of the moderator sealing tube, the outer diameter of the calandria tube and the diameter of fuel pellets, and has no influence to intervals of a pressure tube lattice. The interval of the pressure tube lattice is enlarged without increasing the size of the pressure tube, to improve production efficiency of the reactor and set a coolant void coefficient more negative, thereby enabling to improve self controllability and safety. Further, the reactor scram can be conducted by injecting neutron absorbing liquid. (N.H.)

The Destructive/Non-Destructive Identification of Enameled Pottery, Glass Artifacts and Associated Pigments—A Brief Overview

Directory of Open Access Journals (Sweden)

Philippe Colomban

2013-07-01

Full Text Available The birth of Chemistry can be found in two main practices: (i the Arts du feu (ceramic and glass, metallurgy, i.e., inorganic and solid state chemistry and (ii the preparation of remedies, alcohols and perfumes, dyes, i.e., organic and liquid state chemistry. After a brief survey of the history of (glazed pottery and (enameled glass artifacts, the development of destructive and non-destructive analytical techniques during the last few centuries is reviewed. Emphasis is put on mobile non-destructive Raman microspectroscopy of pigments and their glass/glaze host matrices for chronological/technological expertise. The techniques of white opacification, blue, yellow, green, red, and black coloring, are used as examples to point out the interest of pigments as chronological/technological markers.

Dismantlement and destruction of chemical, nuclear and conventional weapons

International Nuclear Information System (INIS)

Schulte, N.T.

1997-01-01

The safe destruction and dismantling of chemical, nuclear and conventional weapons is of fundamental importance to the security of all countries represented in this volume. Expertise in the field is not confined to one country or organisation: all can benefit from each other. There is an ever present danger of proliferation of weapons of mass destruction: approximately two dozen countries have ongoing programmes to develop or acquire such weapons, and many are also gaining the capability to build air-surface delivery systems. But much can be done to prevent proliferation by reducing leakage of materials and know-how and by solving the problems of the destruction of surplus weapons systems, which has now come to be a key issue. In 13 sessions of the workshop attention was paid to (1) Dismantlement and Destruction of Chemical, Nuclear and Conventional Weapons; (2) Status of Implementation of Arms Control Treaties and Voluntary Commitments; (3) National Perspectives on Cooperation in Disarmament; (4) Stocktaking of National and Bilateral Disposal/Destruction Programmes: Chemical Weapons; (5) Stocktaking of National and Bilateral Disposal/Destruction Programmes: Nuclear Weapons; (6) Stocktaking of National and Bilateral Disposal/Destruction Programmes: Conventional Weapons. Session; (7) Experience with Currently Employed Chemical Destruction Technologies; (8) Alternative Chemical Destruction Technologies; (9) Deactivation, Dismantlement and Destruction of Delivery Systems and Infrastructure for Nuclear Weapons; (10) Storage, Safeguarding and Disposition of Fissile Materials; (11) Technologies for Conversion and Civil Use of Demilitarized Materials; (12) International Organizations; and (13) Environmental Challenges Posed by Chemical and Nuclear Disarmament

Vertical steam generator with slab-type tube-plate with even tube bundle washing

International Nuclear Information System (INIS)

Manek, O.; Masek, V.; Motejl, V.; Quitta, R.

1980-01-01

A shielding plate supporting the tubes attached to the tube plate of a vertical steam generator is mounted above the tube plate. Tube sleeves are designed with a dimensional tolerance relative to the heat transfer tubes and the sleeve end and the tube plate end. A separate space is thus formed above the tube plate in which circulation or feed water is introduced to flow between the branch and the heat transfer tube. This provides intensive washing of heat transfer tubes at a critical point and prevents deposit formation, thus excluding heat transfer tube failures. (J.B.)

Drugs Approved for Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Science.gov (United States)

This page lists cancer drugs approved by the Food and Drug Administration (FDA) for ovarian cancer. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

Signaling pathways and stem cells in uterus and fallopian tubes

NARCIS (Netherlands)

Y. Wang (Yongqian)

2012-01-01

textabstractDuring her fertile years, the endometrium of fertile women undergoes regular cycles of regeneration, differentiation and shedding, driven by changing concentrations of the steroid hormones estradiol and progesterone. In the present study, the role of Wnt/β-catenin signaling in relation

Primary fallopian tube carcinoma: A clinicopathologic analysis and literature review

Directory of Open Access Journals (Sweden)

Hei-Yu Lau

2013-10-01

Conclusion: PFTC is infrequently diagnosed preoperatively or intraoperatively due to its rarity, and has a varied and nonspecific presentation. Only 6.3% of the patients had typical symptoms suggestive of tubal carcinoma. This report may benefit surgeons by providing additional information about the clinicopathologic behavior of PFTC so that patients can be appropriately counseled.

Proliferation in the normal FTE is a hallmark of the follicular phase, not BRCA mutation status.

Science.gov (United States)

George, Sophia H L; Milea, Anca; Shaw, Patricia A

2012-11-15

Women who have inherited germline mutations of BRCA1/BRCA2 are at increased risk of developing high-grade serous carcinoma, and many of these cancers arise in the distal fimbriated end of the fallopian tube. We have previously shown that the fallopian tube epithelia of BRCA1 mutation carriers (FTE-BRCA) have altered signaling pathways compared to nonmutation carriers. In this study, we sought to determine whether these differences result in a proliferative advantage to the epithelia in this high-risk patient population and to investigate whether the postovulation environment of the FTE-BRCA compared to FTE from nonmutation carriers experiences a differential abundance of immune cells. Immunohistochemistry for Ki67, CD3, CD8, CD20, and CD68 was performed on histologically normal tubal epithelium (ampulla, n = 83), fimbria (n = 18) with known ovarian cycle status and germline mutation status and for Ki67 on fimbrial epithelium from women (n = 144) with and without BRCA1 or BRCA2 mutations who underwent risk-reducing salpingo-oophorectomy (RRSO). Serous tubal intraepithelial carcinomas (STIC) with concomitant cancer (n = 15) were also analyzed for presence of immune infiltrates. All slides were digitized and analyzed using automated image analysis software. There was no significant difference in the proliferative index in histologically normal FTE between BRCA1/BRCA2 and non-BRCA, in 144 fimbriae and 83 ampullae. The FTE-BRCA1 epithelia did not exhibit a differential presence of lymphocytes or macrophages, however more macrophages were present in the luteal phase compared to the follicular phase epithelia. In STICs macrophages were more abundant than lymphocytes with an incremental increase noted with disease progression. BRCA1/2 mutation carriers exhibited no significant increase in proliferation in the fallopian tube epithelial cells either in the ampulla or fimbriated ends of the tube. Rather, a significant proliferative increase was defined in the cases determined

Use of CATHENA to model calandria-tube/moderator heat transfer after pressure-tube/calandria-tube ballooning contact

International Nuclear Information System (INIS)

Fan, H.Z.; Bilanovic, Z.; Nitheanandan, T.

2004-01-01

A study was performed to assess the effect of the calandria-tube/moderator heat transfer after pressure-tube/calandria tube ballooning contact using CATHENA. Results of this study indicated that the analytical tool, CATHENA, can be applied for pool boiling heat transfer on the external surface of a large diameter tube, such as the calandria tube used in CANDU reactors. The methodology in such CANDU-generic study can be used to simulate the tube surface with multiple boiling regimes and to assess the benefits of closely coupling thermalhydraulics modelling and fuel/fuel channel behaviour modelling. CATHENA (Canadian Algorithm for THErmalhydraulic Network Analysis) is a one-dimensional, two-fluid thermalhydraulic simulation code designed by AECL to analyse two-phase flow and heat transfer in piping networks. The detailed heat transfer package in CATHENA allows a connection to be established from the multiple solid surfaces of tubes to the surrounding large amount of moderator water, which acts as a heat sink during a postulated loss of coolant event. The generalized heat transfer package within CATHENA allows the tube walls to be divided into several layers in the radial direction and several sectors in the circumferential direction, to account for heat transfer conditions in these two directions. The CATHENA code with the generalized heat transfer package is capable of capturing key pool-boiling phenomena such as nucleate, transition and film boiling heat transfer as well as an ability to model the rewet phenomenon to some extent. A CATHENA input model was generated and used in simulations of selected contact boiling experiment test cases. The transient wall temperatures have been calculated in different portions of the calandria tube. By using this model an adequate agreement was achieved between CATHENA calculation and experimental measurement The CATHENA code enables one to investigate the transient and local thermal-mechanical behaviour of the calandria tube

Application of the leak-before-break concept to steam generator tubes

International Nuclear Information System (INIS)

Keim, E.; Kastner, W.

1994-01-01

The Leak-Before-Break (LBB) behaviour of a piping component means that the length of a crack resulting in a leak is smaller than the critical crack length and that the leak is safety detectable by a suitable monitoring system. The LBB-concept of Siemens/KWU is based on computer codes for the evaluation of critical crack lengths, crack openings, leakage areas and leakage rates, developed by Siemens/KWU. The fracture mechanics analysis supplies the input for the thermal-hydraulic analysis. The resulting leakage rate related to the crack length of a longitudinal or circumferential crack and the minimum detectable values of leakage rate and crack length lead to two criteria, which allow for the LBB-behaviour of the pipe: - the critical crack length must be larger than the crack length being safety detected by leakage monitoring systems (LMS) - the critical crack length must be larger than the crack length being safety detected by non-destructive examination (NDE). This LBB-concept is applied to steam generator (SG) tubes. Two examples, which will be presented, show that this concept is a very useful and effective tool which allows the prediction of LBB-behaviour of SG tubes. (Author)

Investigations on microstructure of Chinese traditional medicine using phase-contrast imaging with microfocus X-ray tube

International Nuclear Information System (INIS)

Wei Xun; Chinese Academy of Sciences, Beijing; Xiao Tiqiao; Chen Min; Liu Lixiang; Luo Yuyu; Du Guohao; Xu Hongjie

2005-01-01

The microscopic morphology of plant cells and their ergastic substances is an important standard for the identification of Chinese traditional medicine. The authors have developed a new method, X-ray phase-contrast imaging (XPCI) based on the microfocus X-ray tube, to explore microstructures of Chinese herbal medicine. The results indicate that XPCI is capable of distinguishing the structures commonly used in the identification. Non-destructive detection and high sensibility are counted among the major advantages of XPCI. The possibility of future applications of XPCI in the field of medicine identification is discussed. (authors)

Improvement of pump tubes for gas guns and shock tube drivers

Science.gov (United States)

Bogdanoff, D. W.

1990-01-01

In a pump tube, a gas is mechanically compressed, producing very high pressures and sound speeds. The intensely heated gas produced in such a tube can be used to drive light gas guns and shock tubes. Three concepts are presented that have the potential to allow substantial reductions in the size and mass of the pump tube to be achieved. The first concept involves the use of one or more diaphragms in the pump tube, thus replacing a single compression process by multiple, successive compressions. The second concept involves a radical reduction in the length-to-diameter ratio of the pump tube and the pump tube piston. The third concept involves shock heating of the working gas by high explosives in a cyclindrical geometry reusable device. Preliminary design analyses are performed on all three concepts and they appear to be quite feasible. Reductions in the length and mass of the pump tube by factors up to about 11 and about 7, respectively, are predicted, relative to a benchmark conventional pump tube.

Frequency of "incidental" serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study.

Science.gov (United States)

Meserve, Emily E K; Mirkovic, Jelena; Conner, James R; Yang, Eric; Muto, Michael G; Horowitz, Neil; Strickland, Kyle C; Howitt, Brooke E; Crum, Christopher P

2017-07-01

Objective The purpose of this study was to determine the prevalence of incidentally discovered serous tubal intraepithelial carcinoma in women without a genetic risk for or history of high grade serous carcinoma (HGSC) in the gynecologic tract. All pathology reports at our institution that included bilateral salpingectomies from January 2006-December 2011 were examined in women >50years old in which the entire tube or the distal one-third was examined histologically with the complete (proximal and distal fallopian tube) or modified (distal one third of the tube) SEE-FIM protocol. Cases were divided into: Group 1, a history of or known risk factors (BRCA1 or BRCA2 mutations) for HGSC and Group 2, those without these attributes for whom a STIC would be unexpected (incidental). Women undergoing unspecified "risk-reducing" procedures were included in Group 1. Of 4051 identified total, 2268 had complete examination of the distal fallopian tube and were age 50 or above. Of these, 1747 were in group 2. Two STICs were identified (0.1%), one associated with a grade 2 endometrial endometrioid adenocarcinoma and one with a low-grade ovarian serous carcinoma in the setting of a serous borderline tumor. Incidental STICs in women over age 50 are uncommon. However, the significance of lesser tubal atypias (0.3% in this study), risk of STIC in women with no epithelial pathology and the risk imposed by coexisting endometrioid neoplasia are unclear and require further study. Copyright © 2017 Elsevier Inc. All rights reserved.

Limits to the Recognizability of Flaws in Non-Destructive Testing Steam-Generator Tubes for Nuclear-Power Plants; Limitations de l'Efficacite de la Detection des Defauts par Essais Non Destructifs de Tubes de Bouilleurs pour Centrales Nucleaires; Predely ehffektivnosti nedestruktivnoj defektoskopii trub parogeneratorov yadernykh ehlektrostantsij; Limites para Distinguir los Defectos en el Ensayo No Destructivo de Tubo para Generadores de Vapor Destinados a Centrales Nucleares

Energy Technology Data Exchange (ETDEWEB)

Kuhlmann, A.; Adamsky, F. -J. [Technischer Ueberwachungs-Verein Reinland e.V., Cologne (Germany)

1965-10-15

In the Federal Republic of Germany there are nuclear reactors under construction with steam generators inside the reactor pressure-vessel. As a result design repairs of steam- generator tubes are very difficult and cause large shut-down times of the nuclear-power plant. It is known that numerous troubles in operating conventional power plants are results of steam-generator tube damages. Because of the high total costs of these reactors it. is necessary to construct the steam generators especially in such a manner that the load factor of the power plant is as high as possible. The Technischer Ueberwachungs-Verein Rheinland was charged to supervise and to test fabrication and construction of the steam generators to see that this part of the plant was as free of defects as possible. The experience gained during this work is of interest for manufacture and construction of steam generators for nuclear-power plants in general. This paper deals with the efficiency limits of non-destructive testing steam-generator tubes. The following tests performed will be discussed in detail: (a) Automatic ultrasonic testing of the straight tubes in the production facility; (b) Combined ultrasonic and radiographic testing of the bent tubes and tube weldings; (c) Other non-destructive tests. (author) [French] En Allemagne, on construit actuellement des generatrices nucleaires dans lesquelles les bouilleurs sont installes a l'interieur du caisson etanche du reacteur. Il s'ensuit que les reparations des tubes des bouilleurs sont tres difficiles et provoquent de longs arrets des centrales nucleaires. On sait que de nombreuses perturbations du fonctionnement des centrales classiques sont dues a des dommages dans les tubes des bouilleurs. C'est en grande partie en raison du prix de revient eleve de ces reacteurs qu'il est necessaire de construire les bouilleurs notamment de sorte que le facteur d'utilisation de la centrale soit aussi eleve que possible. C'est le ' Technischer Ueberwachungs

Non-destructive testing at Chalk River

International Nuclear Information System (INIS)

Hilborn, J.W.

1976-01-01

In 1969 CRNL recognized the need for a strong group skilled in non-destructive test procedures. Within two years a new branch called Quality Control Branch was staffed and working. This branch engages in all aspects of non-destructive testing including development of new techniques, new applications of known technology, and special problems in support of operating reactors. (author)

Empirical analysis of the types of destructiveness of law enforcement officers

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Zlokazov K.V.

2014-12-01

Full Text Available The variety of existing scientific concepts of the problem of personality destructiveness is shown. The character of such general conclusions does not facilitate the cognition and prediction of destructive phenomena. The author proves the necessity to develop psychological theory of destructiveness which methodologically unites well-known but separate phenomena of psychological life of an individual. The fundamental propositions of this theory are argued: destructiveness is an active behaviour; it is aimed at perceived goal and formed on the basis of need perceived by an individual. The following features of destructiveness are distinguished: individual typological, regulatory, value characteristics of personality; peculiarities of person’s attitude to significant aspects of life – to the self, society and professional activity. The author proposes his own method of destructiveness diagnostics aimed at describing destructive and constructive components of social and professional activity of a person. Diagnostics indicators are the following: typological preconditions of destructiveness; features of regulation of activity and relations; value characteristics of individuals related to destructiveness. Indicators, describing the level of personal disadaptation, are provided. Personality destructiveness indicators of 211 law enforcement officers (93 % – males, mean age – 34 were analyzed, which allowed to group and describe psychological characteristics of 4 types of destructiveness. They are: socially alienated – 31 % of respondents, socially destructive – 29 %, asocially destructive – 23 %, asocially alienated – 17 %. This typology allows to generalize psychological preconditions of destructive and constructive behaviour of law enforcement officers. The author proposes further analyzing the provisions of conception of personality destructiveness.

27 CFR 25.223 - Destruction of beer off brewery premises.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Destruction of beer off... TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS BEER Voluntary Destruction § 25.223 Destruction of beer off brewery premises. (a) Destruction without supervision. A brewer may destroy beer without...

Indirect self-destructiveness in individuals with schizophrenia

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Konstantinos Tsirigotis

2017-06-01

Full Text Available Objective: To explore the indirect self-destructiveness syndrome in patients with schizophrenia. Methods: Two hundred individuals with paranoid schizophrenia (117 men and 83 women, mean age 37.15 years, all in remission, were examined using the Polish version of the Chronic Self-Destructiveness Scale. Two hundred well-matched healthy individuals served as a control group. Results: The intensity of indirect self-destructiveness was greater in the schizophrenia group than in controls. The intensity of each manifestation was as follows (in decreasing order: helplessness and passiveness in the face of difficulties (A5, personal and social neglects (A3, lack of planfulness (A4, poor health maintenance (A2, transgression and risk (A1. Conclusion: Patients with schizophrenia displayed more behaviors that were indirectly self-destructive than healthy controls; they scored better than healthy controls only on caring for their own health. The patients showed the lowest intensity of behaviors connected with the active form of indirect self-destructiveness, and the highest intensity of behaviors connected with the passive form. These findings may enable delivery of more effective forms of pharmacological and psychosocial help to patients with schizophrenia.

Vibro-impact responses of a tube with tube--baffle interaction. [LMFBR

Energy Technology Data Exchange (ETDEWEB)

Shin, Y S; Sass, D E; Jendrzejczyk, J A

1978-01-01

The relatively small, inherent tube-to-baffle hole clearances associated with manufacturing tolerances in heat exchangers affect the vibrational characteristics and the response of the tube. Numerical studies were made to predict the vibro-impact response of a tube with tube-baffle interaction. The finite element method has been employed with a non-linear elastic contact spring-dashpot to model the effect of the relative approach between the tube and the baffle plate. The coupled equations of motion are directly integrated with a proportional system damping represented by a linear combination of mass and stiffness. Lumped mass approach with explicit time integration scheme was found to be a suitable choice for tube-baffle impacting analysis. Fourier analyses indicate that the higher mode contributions to the tube response are significant for strong tube-baffle impacting. The contact damping forces are negligible compared with the contact spring forces. The numerical analysis results are in reasonably good agreement with those of the experiments.

Bender/Coiler for Tubing

Science.gov (United States)

Stoltzfus, J. M.

1983-01-01

Easy-to-use tool makes coils of tubing. Tubing to be bend clamped with stop post. Die positioned snugly against tubing. Operator turns handle to slide die along tubing, pushing tubing into spiral groove on mandrel.