WorldWideScience

Sample records for facility ctf located

  1. Cryogenic piping material selection for the Component Test Facility (CTF)

    Science.gov (United States)

    St. Cyr, William W.

    1991-01-01

    The anticipated high cost of the 8500 psi cryogenic and 15,000 psi gas piping systems used in the CTF at NASA's John C. Stennis Space Center led to the consideration of high-strength materials for these piping systems. Based on years of satisfactory service using austenitic stainless steels in cryogenic applications, particularly for hydrogen service, consideration was limited to the austenitic stainless steels. Attention was focused on alternatives to the 304/304L grades of stainless steel traditionally used in these applications. This paper discusses the various considerations that resulted in the decision to continue using 304/304L for the cryogenic piping and the selection of the nitrogen-strengthened 21Cr-6Ni-9Mn alloy (UNS S21903) for the high-pressure gas systems at the CTF.

  2. Beam Dynamics for the Preliminary Phase of the New CLIC Test Facility (CTF3)

    CERN Document Server

    Corsini, R; Rinolfi, Louis; Risselada, Thys; Royer, P; Tecker, F A

    2001-01-01

    In the framework of the CLIC (Compact Linear Collider) RF power source studies, the scheme of electron pulse compression and bunch frequency mulitiplication, using injection by RF deflectors into an isochronous ring, will be tested, at low charge, during the preliminary phase of the new CLIC Test Facility (CTF3) at CERN. In this paper, we describe the beam dynamics studies made in order to assess the feasibility of the bunch combination experiment, as well as the related beam measurements performed on the LEP Pre-Injector complex (LPI) before its transformation into CTF3

  3. FUSION NUCLEAR SCIENCE FACILITY (FNSF) BEFORE UPGRADE TO COMPONENT TEST FACILITY (CTF)

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Yueng Kay Martin [ORNL; Canik, John [ORNL; Diem, Stephanie J [ORNL; Milora, Stanley L [ORNL; Park, J. M. [Oak Ridge National Laboratory (ORNL); Sontag, Aaron C [ORNL; Fogarty, P. J. [Oak Ridge National Laboratory (ORNL); Lumsdaine, Arnold [ORNL; Murakami, Masanori [ORNL; Burgess, Thomas W [ORNL; Cole, Michael J [ORNL; Katoh, Yutai [ORNL; Korsah, Kofi [ORNL; Patton, Bradley D [ORNL; Wagner, John C [ORNL; Yoder, III, Graydon L [ORNL

    2011-01-01

    The compact (R0~1.2-1.3m) Fusion Nuclear Science Facility (FNSF) is aimed at providing a fully integrated, continuously driven fusion nuclear environment of copious fusion neutrons. This facility would be used to test, discover, and understand the complex challenges of fusion plasma material interactions, nuclear material interactions, tritium fuel management, and power extraction. Such a facility properly designed would provide, initially at the JET-level plasma pressure (~30%T2) and conditions (e.g., Hot-Ion H-Mode, Q<1)), an outboard fusion neutron flux of 0.25 MW/m2 while requiring a fusion power of ~19 MW. If and when this research is successful, its performance can be extended to 1 MW/m2 and ~76 MW by reaching for twice the JET plasma pressure and Q. High-safety factor q and moderate-plasmas are used to minimize or eliminate plasma-induced disruptions, to deliver reliably a neutron fluence of 1 MW-yr/m2 and a duty factor of 10% presently anticipated for the FNS research. Success of this research will depend on achieving time-efficient installation and replacement of all internal components using remote handling (RH). This in turn requires modular designs for the internal components, including the single-turn toroidal field coil center-post. These device goals would further dictate placement of support structures and vacuum weld seals behind the internal and shielding components. If these goals could be achieved, the FNSF would further provide a ready upgrade path to the Component Test Facility (CTF), which would aim to test, for 6 MW-yr/m2 and 30% duty cycle, the demanding fusion nuclear engineering and technologies for DEMO. This FNSF-CTF would thereby complement the ITER Program, and support and help mitigate the risks of an aggressive world fusion DEMO R&D Program. The key physics and technology research needed in the next decade to manage the potential risks of this FNSF are identified.

  4. Review of the Drive Beam Stabilization in the CLIC Test Facility CTF3

    CERN Document Server

    Dubrovskiy, A; Skowronski, P; Tecker, F; Persson, T

    2013-01-01

    CTF3 is a Test Facility focusing on beam-based studies of the key concepts of the Compact Linear Collider CLIC. Over the past several years many aspects of the CLIC two-beam acceleration scheme were studied in CTF3, including the crucial issue of drive beam stability. The main sources of drifts and instabilities have been identified and mitigated, helping to improve the machine performance and showing significant progress towards the experimental demonstration of the very stringent requirements on current, energy and phase stability needed in CLIC. In this paper, the more effective techniques and feed-backs are summarized. The latest measurements on beam stability are reported and their relevance to CLIC is discussed.

  5. CARE-JRA2* Activities on Photo-Injectors and CLIC Test Facility (CTF3)

    CERN Document Server

    Rinolfi, Louis

    2005-01-01

    In the frame of the CARE project, there is a Joint Research Activity (JRA2) called PHIN (PHoto-INjectors). The main objective of this JRA is to perform Research and Development on charge-production by interaction of a laser pulse with material within RF fields and improve or extend existing infrastructures. Another activity of PHIN is the coordination of the activities of various Institutes concerning photo-injectors. A brief review of the work of the eight European laboratories involved in PHIN is presented. One of these R&D topics is the construction of a photo-injector for the CLIC Test Facility (CTF3). In this context the status of CTF3 and its main goals - the demonstration of the feasibility of the key issues of the CLIC two-beam acceleration scheme - is also presented.

  6. Development of a Beam-based Phase Feedforward Demonstration at the CLIC Test Facility (CTF3)

    CERN Document Server

    AUTHOR|(CDS)2083344; Christian, Glenn

    The Compact Linear Collider (CLIC) is a proposal for a future linear electron--positron collider that could achieve collision energies of up to 3~TeV. In the CLIC concept the main high energy beam is accelerated using RF power extracted from a high intensity drive beam, achieving an accelerating gradient of 100~MV/m. This scheme places strict tolerances on the drive beam phase stability, which must be better than $0.2^\\circ$ at 12~GHz. To achieve the required phase stability CLIC proposes a high bandwidth (${>}17.5$~MHz), low latency drive beam ``phase feedforward'' (PFF) system. In this system electromagnetic kickers, powered by 500~kW amplifiers, are installed in a chicane and used to correct the phase by deflecting the beam on to longer or shorter trajectories. A prototype PFF system has been installed at the CLIC Test Facility, CTF3; the design, operation and commissioning of which is the focus of this work. Two kickers have been installed in the pre-existing chicane in the TL2 transfer line at CTF3 for t...

  7. RF power source for the compact linear collider test facility (CTF3)

    CERN Document Server

    McMonagle, G; Brown, Peter; Carron, G; Hanni, R; Mourier, J; Rossat, G; Syratchev, I V; Tanner, L; Thorndahl, L

    2004-01-01

    The CERN CTF3 facility will test and demonstrate many vital components of CLIC (Compact Linear Collider). This paper describes the pulsed RF power source at 2998.55 MHz for the drive-beam accelerator (DBA), which produces a beam with an energy of 150 MeV and a current of 3.5 Amps. Where possible, existing equipment from the LEP preinjector, especially the modulators and klystrons, is being used and upgraded to achieve this goal. A high power RF pulse compression system is used at the output of each klystron, which requires sophisticated RF phase programming on the low level side to achieve the required RF pulse. In addition to the 3 GHz system two pulsed RF sources operating at 1.5 GHz are being built. The first is a wide-band, low power, travelling wave tube (TWT) for the subharmonic buncher (SHB) system that produces a train of "phase coded" subpulses as part of the injector scheme. The second is a high power narrow band system to produce 20 MW RF power to the 1.5 GHz RF deflectors in the delay loop situate...

  8. IHS Facility Locator

    Data.gov (United States)

    U.S. Department of Health & Human Services — This map can be used to find an Indian Health Service, Tribal or Urban Indian Health Program facility. This map can be used to: Zoom in to a general location to...

  9. RF Pulse compression stabilization at the CTF3 CLIC test facility

    CERN Document Server

    Dubrovskiy, Alexey

    2010-01-01

    In the CTF3 accelerator, the RF produced by each of ten 3 GHz klystrons goes through waveguides, RF pulse compressors and splitters. The RF phase and power transformation of these devices depend on their temperature. The quantitative effect of the room temperature variation on the RF was measured. It is the major source of undesired changes during the CTF3 operation. An RF phaseloop and a compressor temperature stabilization are developed to suppress the phase fluctuation and the power profile change due to the temperature variation. The implementation is transparent for operators, it does not limit anyhow the flexibility of RF manipulations. Expected and measured suppression characteristics will be given.

  10. Operational Performance and Improvements to the RF Power Sources for the Compact Linear Collider Test Facility (CTF3) at CERN

    CERN Document Server

    McMonagle, Gerard

    2006-01-01

    The CERN CTF3 facility is being used to test and demonstrate key technical issues for the CLIC (Compact Linear Collider) study. Pulsed RF power sources are essential elements in this test facility. Klystrons at S-band (29998.55 GHz), in conjunction with pulse compression systems, are used to power the Drive Beam Accelerator (DBA) to achieve an electron beam energy of 150 MeV. The L-Band RF system, includes broadband Travelling Wave Tubes (TWTs) for beam bunching with 'phase coded' sub pulses in the injector and a narrow band high power L-Band klystron powering the transverse 1.5GHz RF deflector in the Delay Loop immediately after the DBA. This paper describes these different systems and discusses their operational performance.

  11. Operational performance and improvements to the rf power sources for the Compact Linear Collider Test Facility (CTF3) at CERN

    CERN Document Server

    McMonagle, Gerard

    2006-01-01

    The CERN CTF3 facility is being used to test and demonstrate key technical issues for the CLIC (Compact Linear Collider) study. Pulsed RF power sources are essential elements in this test facility. Klystrons at S-band (29998.55 GHz), in conjunction with pulse compression systems, are used to power the Drive Beam Accelerator (DBA) to achieve an electron beam energy of 150 MeV. The L-Band RF system, includes broadband Travelling Wave Tubes (TWTs) for beam bunching with 'phase coded' sub pulses in the injector and a narrow band high power L-Band klystron powering the transverse 1.5 GHz RF deflector in the Delay Loop immediately after the DBA. This paper describes these different systems and discusses their operational performance.

  12. Stabilization of the Beam Intensity in the Linac at the CTF3 CLIC Test Facility

    CERN Document Server

    Dubrovskiy, A; Bathe, BN; Srivastava, S

    2013-01-01

    A new electron beam stabilization system has been introduced in CTF3 in order to open new possibilities for CLIC beam studies in ultra-stable conditions and to provide a sustainable tool to keep the beam intensity and energy at its reference values for long term operations. The stabilization system is based on a pulse-to-pulse feedback control of the electron gun to compensate intensity deviations measured at the end of the injector and at the beginning of the linac. Thereby it introduces negligible beam distortions at the end of the linac and it significantly reduces energy deviations. A self-calibration mechanism has been developed to automatically configure the feedback controller for the optimum performance. The residual intensity jitter of 0.045% of the stabilized beam was measured whereas the CLIC requirement is 0.075%.

  13. On Constrained Facility Location Problems

    Institute of Scientific and Technical Information of China (English)

    Wei-Lin Li; Peng Zhang; Da-Ming Zhu

    2008-01-01

    Given m facilities each with an opening cost, n demands, and distance between every demand and facility,the Facility Location problem finds a solution which opens some facilities to connect every demand to an opened facility such that the total cost of the solution is minimized. The k-Facility Location problem further requires that the number of opened facilities is at most k, where k is a parameter given in the instance of the problem. We consider the Facility Location problems satisfying that for every demand the ratio of the longest distance to facilities and the shortest distance to facilities is at most w, where w is a predefined constant. Using the local search approach with scaling technique and error control technique, for any arbitrarily small constant ∈ > 0, we give a polynomial-time approximation algorithm for the ω-constrained Facility Location problem with approximation ratio 1 + √ω + 1 + ∈, which significantly improves the previous best known ratio (ω + 1)/α for some 1 ≤α≤ 2, and a polynomial-time approximation algorithm for the ω-constrained κ-Facility Location problem with approximation ratio ω + 1 + ∈. On the aspect of approximation hardness, we prove that unless NP (C) DTIME(nO(loglogn)), the ω-constrained Facility Location problem cannot be approximated within 1 + √ω-1,which slightly improves the previous best known hardness result 1.243 + 0.316 ln(ω - 1). The experimental results on the standard test instances of Facility Location problem show that our algorithm also has good performance in practice.

  14. rf deflector design of the CLIC test facility CTF3 delay loop and beam loading effect analysis

    Directory of Open Access Journals (Sweden)

    David Alesini

    2009-03-01

    Full Text Available Beam injection and extraction in the delay loop of the CLIC Test Facility 3 (CTF3 for recombination of adjacent bunch trains, is performed by a specially designed rf deflector. A standing wave structure has been chosen for this purpose. Three possible solutions have been investigated, and a comparative analysis is presented. All of them satisfy the essential requirements of the system up to the maximum foreseen energy with the existing klystron. The final design of the rf deflector consists of two identical cavities connected to the rf power source through a hybrid junction that equally splits the power and isolates the klystron from reflections. The rf deflector design, the results of electromagnetic simulations, and the low level rf measurements are illustrated. The impact of beam loading in the rf deflectors on the transverse beam dynamics is also analyzed. The general expression of the single passage transverse wakefield is obtained and a dedicated tracking code has been written to study the multibunch multiturn effects. A complete analysis for different machine parameters and injection errors is presented and discussed. These numerical simulations indicate a tolerable beam emittance growth due to the transverse wakefield in the rf deflectors.

  15. Reliable Facility Location Problem with Facility Protection.

    Science.gov (United States)

    Tang, Luohao; Zhu, Cheng; Lin, Zaili; Shi, Jianmai; Zhang, Weiming

    2016-01-01

    This paper studies a reliable facility location problem with facility protection that aims to hedge against random facility disruptions by both strategically protecting some facilities and using backup facilities for the demands. An Integer Programming model is proposed for this problem, in which the failure probabilities of facilities are site-specific. A solution approach combining Lagrangian Relaxation and local search is proposed and is demonstrated to be both effective and efficient based on computational experiments on random numerical examples with 49, 88, 150 and 263 nodes in the network. A real case study for a 100-city network in Hunan province, China, is presented, based on which the properties of the model are discussed and some managerial insights are analyzed.

  16. CTF3 Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Ruth, Ronald D

    2003-03-13

    The design of CLIC is based on a two-beam scheme, where short pulses of high power 30 GHz RF are extracted from a drive beam running parallel to the main beam. The 3rd generation CLIC Test Facility (CTF3) will demonstrate the generation of the drive beam with the appropriate time structure, the extraction of 30 GHz RF power from this beam, as well as acceleration of a probe beam with 30 GHz RF cavities. The project makes maximum use of existing equipment and infrastructure of the LPI complex, which became available after the closure of LEP.

  17. Mental Health Treatement Facilities Locator

    Data.gov (United States)

    U.S. Department of Health & Human Services — An online resource for locating mental health treatment facilities and programs supported by the Substance Abuse and Mental Health Services Administration (SAMHSA)....

  18. Development of a Bunch Frequency Monitor for the Preliminary Phase of the CLIC Test Facility CTF3

    CERN Document Server

    Caspers, Friedhelm; Ferrari, A; Rinolfi, Louis; Royer, P; Rydberg, A; Tecker, F A

    2003-01-01

    In the framework of the CLIC RF power source studies, the feasibility of the electron bunch train combination by injection with RF deflectors into an isochronous ring has been successfully demonstrated in the preliminary phase of CTF3. A new method, based on beam frequency spectrum analysis, was experimented to monitor this scheme. A coaxial pick-up and its read-out electronics were designed and mounted in the CTF3 ring to allow comparison of the amplitudes of five harmonics of the fundamental beam frequency (3 GHz) while combining the bunch trains. The commissioning of the monitor was a successful proof of principle for this new method, despite the short length of the bunch trains and the presence of parasitic signals associated to high-order waveguide modes propagating with the beam inside the pipe.

  19. Modeling discrete competitive facility location

    CERN Document Server

    Karakitsiou, Athanasia

    2015-01-01

    This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...

  20. Uncapacitated facility location problems: contributions

    Directory of Open Access Journals (Sweden)

    Galvão Roberto Diéguez

    2004-01-01

    Full Text Available The objective of the present paper is to review my personal contributions in the field of uncapacitated facility location problems. These contributions took place throughout my academic career, from the time I was a Ph.D. student at Imperial College to the present day. They cover approximately 30 years, from 1973 to 2003; they address: algorithms developed for the p-median problem and for a general formulation of uncapacitated location problems; the study of dynamic location models; covering and hierarchical location problems; queuing-based probabilistic location models. The contributions encompass theoretical developments, computational algorithms and practical applications. All work took place in an academic environment, with the invaluable collaboration of colleagues (both in Brazil and abroad and research students at COPPE. Each section in the paper is dedicated to a topic that involves a personal contribution. Every one of them is placed within the context of the existing literature.

  1. Space nuclear thermal propulsion: Evaluation of PIPET at the INEL's CTF

    Science.gov (United States)

    Hill, Thomas J.

    1993-01-01

    The scope of the report is to evaluate the feasibility and provide a rough order of magnitude (ROM) estimate of cost and schedule for testing the PIPET Reactors in the Contained Test Facility (CTF). The topics are presented in viewgraph form and include the following: PIPET Facility requirements; existing CTF Facilities; CTF background; CTR report assumptions; ETS size information; ETS component arrangement evaluation; proposed ETS configuration; the cost evaluation results; and CTF schedule.

  2. Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF aggregate is sufficient to cause cell death.

    Directory of Open Access Journals (Sweden)

    Makoto Takahashi

    Full Text Available The human α1A voltage-dependent calcium channel (Cav2.1 is a pore-forming essential subunit embedded in the plasma membrane. Its cytoplasmic carboxyl(C-tail contains a small poly-glutamine (Q tract, whose length is normally 4∼19 Q, but when expanded up to 20∼33Q, the tract causes an autosomal-dominant neurodegenerative disorder, spinocerebellar ataxia type 6 (SCA6. A recent study has shown that a 75-kDa C-terminal fragment (CTF containing the polyQ tract remains soluble in normal brains, but becomes insoluble mainly in the cytoplasm with additional localization to the nuclei of human SCA6 Purkinje cells. However, the mechanism by which the CTF aggregation leads to neurodegeneration is completely elusive, particularly whether the CTF exerts more toxicity in the nucleus or in the cytoplasm. We tagged recombinant (rCTF with either nuclear-localization or nuclear-export signal, created doxycyclin-inducible rat pheochromocytoma (PC12 cell lines, and found that the CTF is more toxic in the cytoplasm than in the nucleus, the observations being more obvious with Q28 (disease range than with Q13 (normal-length. Surprisingly, the CTF aggregates co-localized both with cAMP response element-binding protein (CREB and phosphorylated-CREB (p-CREB in the cytoplasm, and Western blot analysis showed that the quantity of CREB and p-CREB were both decreased in the nucleus when the rCTF formed aggregates in the cytoplasm. In human brains, polyQ aggregates also co-localized with CREB in the cytoplasm of SCA6 Purkinje cells, but not in other conditions. Collectively, the cytoplasmic Cav2.1-CTF aggregates are sufficient to cause cell death, and one of the pathogenic mechanisms may be abnormal CREB trafficking in the cytoplasm and reduced CREB and p-CREB levels in the nuclei.

  3. Effects of the beam loading in the rf deflectors of the CLIC test facility CTF3 combiner ring

    Directory of Open Access Journals (Sweden)

    David Alesini

    2004-04-01

    Full Text Available In this paper we study the impact of the rf deflectors beam loading on the transverse beam dynamics of the CTF3 combiner ring. A general expression for the single-passage wake field is obtained. Different approximated formulas are derived applying linearization of the rf deflector dispersion curve either on a limited or an unlimited frequency range. A dedicated tracking code has been written to study the multibunch multiturn effects on the transverse beam dynamics. The numerical simulations reveal that the beam emittance growth due to the wake field in the rf deflectors is a small fraction of the design emittance if the trains are injected perfectly on axis. Nevertheless in case of injection errors the final emittance growth strongly depends on the betatron phase advance between the rf deflectors. If the finite bunch length is included in the tracking code, the scenario for the central part of the bunches does not change. However, for some particular injection errors, the tails of the bunches can increase the total transverse bunch emittances.

  4. Oil Storage Facilities - Storage Tank Locations

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — A Storage Tank Location is a DEP primary facility type, and its sole sub-facility is the storage tank itself. Storage tanks are aboveground or underground, and are...

  5. The CLIC Test Facility (CTF3) which allowed the first electron beam recombination in order to multiply the RF frequency from 3 GHz up to 15 GHz.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 0210005_11: The CTF3 linac accelerates an electron beam up to 350 MeV. Photo 0210005_1: At the front, the yellow dipole is used for the spectrometer line. At the back, a doublet of blue quadrupole for the matching. Photo 0210005_03: The CTF3 transfer line between the electron linac and the isochronous ring. Photo 0210005_04: One arc of the EPA isochronous ring. Photo 0210005_06: The CTF3 bunching system. The first RF wave guide feeds the Pre-Buncher while the second RF wave guide feeds the Buncher. They provide a bunched electron beam at 4 MeV. The blue magnet is a solenoid around the Buncher. Photo 0210005_07: A LIL accelerating structure used for CTF3. It is 4.5 meters long and provides an energy gain of 45 MeV. One can see 3 quadrupoles around the RF structure.

  6. Recycling Facilities - Land Recycling Cleanup Locations

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Land Recycling Cleanup Location Land Recycling Cleanup Locations (LRCL) are divided into one or more sub-facilities categorized as media: Air, Contained Release or...

  7. Recycling Facilities - Land Recycling Cleanup Locations

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Land Recycling Cleanup Location Land Recycling Cleanup Locations (LRCL) are divided into one or more sub-facilities categorized as media: Air, Contained Release or...

  8. Substance Abuse Treatment Facilities Locator

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Substance Abuse and Mental Health Services Administration (SAMHSA) provides on-line resource for locating drug and alcohol abuse treatment programs. The...

  9. Location - Managed Facility - St. Paul District (MVP)

    Data.gov (United States)

    Army Corps of Engineers, Department of the Army, Department of Defense — St. Paul District - US Army Corps of Engineers Managed Facility locations. District headquarters, Natural Resource, Recreation, Lock and Dam, and Regulatory offices...

  10. Measuring the longitudinal bunch profile at CTF3

    CERN Document Server

    Dabrowski, A E; Bettoni, S; Braun†, H H; Corsini, R; Döbert, S; Egger, D; Lefevre, T; Rabiller, A; Shaker, H; Soby, L; Skowronski, P K; Tecker, F; Velasco, M

    2010-01-01

    The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration in order to test the feasibility of the proposed Compact Linear Collider (CLIC) two-beam acceleration scheme. The monitoring and control of the bunch length throughout the CTF3 complex is important since this affects the efficiency and the stability of the final RF power production process. Bunch length diagnostics therefore form an essential component of the beam instrumentation at CTF3. This paper presents longitudinal profile measurements based on Streak camera and non-destructive RF power and microwave spectrometry techniques.

  11. CTF Theory Manual

    Energy Technology Data Exchange (ETDEWEB)

    Avramova, Maria N. [Pennsylvania State Univ., University Park, PA (United States); Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-05-25

    Coolant-Boiling in Rod Arrays|Two Fluids (COBRA-TF) is a thermal/ hydraulic (T/H) simulation code designed for light water reactor (LWR) vessel analysis. It uses a two-fluid, three-field (i.e. fluid film, fluid drops, and vapor) modeling approach. Both sub-channel and 3D Cartesian forms of 9 conservation equations are available for LWR modeling. The code was originally developed by Pacific Northwest Laboratory in 1980 and had been used and modified by several institutions over the last few decades. COBRA-TF also found use at the Pennsylvania State University (PSU) by the Reactor Dynamics and Fuel Management Group (RDFMG) and has been improved, updated, and subsequently re-branded as CTF. As part of the improvement process, it was necessary to generate sufficient documentation for the open-source code which had lacked such material upon being adopted by RDFMG. This document serves mainly as a theory manual for CTF, detailing the many two-phase heat transfer, drag, and important accident scenario models contained in the code as well as the numerical solution process utilized. Coding of the models is also discussed, all with consideration for updates that have been made when transitioning from COBRA-TF to CTF. Further documentation outside of this manual is also available at RDFMG which focus on code input deck generation and source code global variable and module listings.

  12. CTF Preprocessor User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Avramova, Maria [Pennsylvania State Univ., University Park, PA (United States); Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-05-26

    This document describes how a user should go about using the CTF pre- processor tool to create an input deck for modeling rod-bundle geometry in CTF. The tool was designed to generate input decks in a quick and less error- prone manner for CTF. The pre-processor is a completely independent utility, written in Fortran, that takes a reduced amount of input from the user. The information that the user must supply is basic information on bundle geome- try, such as rod pitch, clad thickness, and axial location of spacer grids|the pre-processor takes this basic information and determines channel placement and connection information to be written to the input deck, which is the most time-consuming and error-prone segment of creating a deck. Creation of the model is also more intuitive, as the user can specify assembly and water-tube placement using visual maps instead of having to place them by determining channel/channel and rod/channel connections. As an example of the bene t of the pre-processor, a quarter-core model that contains 500,000 scalar-mesh cells was read into CTF from an input deck containing 200,000 lines of data. This 200,000 line input deck was produced automatically from a set of pre-processor decks that contained only 300 lines of data.

  13. A Decision Model for Locating Controversial Facilities

    Science.gov (United States)

    Mumphrey, Anthony J.; And Others

    1971-01-01

    Locating controversial public facilities, such as highways or airports, that generate significant public opposition requires a more sophisticated methodology than the traditional least cost" procedures for minimizing physical costs. Two models--a short-run political placation" model and a long-run welfare distribution" model--evaluate the…

  14. Competitive facility location along a highway

    NARCIS (Netherlands)

    Ahn, H.-K.; Cheng, S.-W.; Cheong, O.; Golin, M.; Oostrum, R. van

    2001-01-01

    We consider a competitive facility location problem with two players. Players alternate placing points, one at a time, into the playing arena, until each of them has placed n points. The arena is then subdivided according to the nearest-neighbor rule, and the player whose points control the

  15. Kali Linux CTF blueprints

    CERN Document Server

    Buchanan, Cameron

    2014-01-01

    Taking a highly practical approach and a playful tone, Kali Linux CTF Blueprints provides step-by-step guides to setting up vulnerabilities, in-depth guidance to exploiting them, and a variety of advice and ideas to build and customising your own challenges. If you are a penetration testing team leader or individual who wishes to challenge yourself or your friends in the creation of penetration testing assault courses, this is the book for you. The book assumes a basic level of penetration skills and familiarity with the Kali Linux operating system.

  16. Facility Location with Double-peaked Preferences

    DEFF Research Database (Denmark)

    Filos-Ratsikas, Aris; Li, Minming; Zhang, Jie

    2015-01-01

    We study the problem of locating a single facility on a real line based on the reports of self-interested agents, when agents have double-peaked preferences, with the peaks being on opposite sides of their locations. We observe that double-peaked preferences capture real-life scenarios and thus...... complement the well-studied notion of single-peaked preferences. We mainly focus on the case where peaks are equidistant from the agents’ locations and discuss how our results extend to more general settings. We show that most of the results for single-peaked preferences do not directly apply to this setting...

  17. Optimization of preventive health care facility locations

    Directory of Open Access Journals (Sweden)

    McGregor S

    2010-03-01

    Full Text Available Abstract Background Preventive health care programs can save lives and contribute to a better quality of life by diagnosing serious medical conditions early. The Preventive Health Care Facility Location (PHCFL problem is to identify optimal locations for preventive health care facilities so as to maximize participation. When identifying locations for preventive health care facilities, we need to consider the characteristics of the preventive health care services. First, people should have more flexibility to select service locations. Second, each preventive health care facility needs to have a minimum number of clients in order to retain accreditation. Results This paper presents a new methodology for solving the PHCFL problem. In order to capture the characteristics of preventive health care services, we define a new accessibility measurement that combines the two-step floating catchment area method, distance factor, and the Huff-based competitive model. We assume that the accessibility of preventive health care services is a major determinant for participation in the service. Based on the new accessibility measurement, the PHCFL problem is formalized as a bi-objective model based on efficiency and coverage. The bi-objective model is solved using the Interchange algorithm. In order to accelerate the solving process, we implement the Interchange algorithm by building two new data structures, which captures the spatial structure of the PHCFL problem. In addition, in order to measure the spatial barrier between clients and preventive health care facilities accurately and dynamically, this paper estimates travelling distance and travelling time by calling the Google Maps Application Programming Interface (API. Conclusions Experiments based on a real application for the Alberta breast cancer screening program show that our work can increase the accessibility of breast cancer screening services in the province.

  18. Location selection criteria for supplementary motorway facilities

    Directory of Open Access Journals (Sweden)

    Malobabić Radomir

    2002-01-01

    Full Text Available Supplementary contents along motorways are rather important facilities for a safe and secure functioning of a substantial part of the road transport system. In the paper, it has been stressed that our practice has not dealt with this problem satisfactorily throughout the motorways design process and especially in the realization phase. Therefore, the solving of this major issue ought to be approached systematically and planning oriented so as to achieve an optimal effect of supplementary contents in the motorways’ exploitation. The role of these facilities is multifold. Some relate to a safer road functioning and some enable a more comfortable and secure traveling. To make them work as a system it is indispensable to set up location selection criteria and rules for the complementary facilities Respecting the adequate rhythm and function dominance is exceptionally important as well as establishing the traffic safety and applying high ecological standards.

  19. CTF3 Drive Beam Injector Optimisation

    CERN Document Server

    AUTHOR|(CDS)2082899; Doebert, S

    2015-01-01

    In the Compact Linear Collider (CLIC) the RF power for the acceleration of the Main Beam is extracted from a high-current Drive Beam that runs parallel to the main linac. The main feasibility issues of the two-beam acceleration scheme are being demonstrated at CLIC Test Facility 3 (CTF3). The CTF3 Drive Beam injector consists of a thermionic gun followed by the bunching system and two accelerating structures all embedded in solenoidal magnetic field and a magnetic chicane. Three sub-harmonic bunchers (SHB), a prebuncher and a travelling wave buncher constitute the bunching system. The phase coding process done by the sub-harmonic bunching system produces unwanted satellite bunches between the successive main bunches. The beam dynamics of the CTF3 Drive Beam injector is reoptimised with the goal of improving the injector performance and in particular decreasing the satellite population, the beam loss in the magnetic chicane and the beam emittance in transverse plane compare to the original model based on P. Ur...

  20. Work plan, health and safety plan, and quality assurance project plan for hazardous waste removal at the CTF K-1654B underground collection tank

    Energy Technology Data Exchange (ETDEWEB)

    Panter, M.S.; Burman, S.N.; Landguth, D.C.; Uziel, M.S.

    1991-10-01

    The Central Training Facility (CTF), located on Bear Creek Road approximately two miles south of the K-25 Site, is utilized for training security personnel at Martin Marietta Energy Systems, Inc., Oak Ridge, Tennessee. At the request of the CTF staff, this plan has been developed for the removal of the waste contents in the facility`s 500-gal septic tank and associated distribution box. The septic tank and distribution box were historically located beneath the K-1654B trailer and adjacent to the K-1654A Indoor Firing Range. Recently, however, the K-1654B trailer was removed to accommodate the objectives of this work plan as well as future construction activities planned at CTF. The purpose of this plan is to develop and assign responsibilities, establish personnel protection requirements and mandatory safety procedures, and provide for contingencies that may arise while operations are being conducted by ORNL/MAD at the CTF K-1654B underground collection tank site. This document addresses requirements of 29 CFR 1910.120, Final Rule, with respect to aspects of health and safety applicable to an underground collection tank waste removal.

  1. CTF3 Injector Profile Monitor

    CERN Document Server

    Bal, C; Burger, S; Lefèvre, T; CERN. Geneva. AB Department

    2004-01-01

    The electron gun of the CLIC Test Facility 3 (CTF3) produces 15.6µs long pulses with an energy of 140keV and a current that can be as high as 9A. For the nominal beam operation a 5.4A beam current is generated and sent downstream into the bunching system and the rest of the accelerator. The corresponding beam charge will induce a thermal load that most of the materials, considered as radiators, would not withstand. With this problem in mind, we have built a beam imaging system, installed just after the gun and equipped with two screens. The first one is a phosphorescent screen which yields a high signal and can be for low beam currents. The second screen, a thin graphite foil, is used as a forward OTR radiator and can stand the full beam intensity. Moreover, the time resolution of OTR is very good, in the femtosecond range. This allows the observation of the evolution in time of the beam size during the pulse by using a gated camera. We present in this paper the first results obtained using this system.

  2. 7 CFR 1738.12 - Location of facilities.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Location of facilities. 1738.12 Section 1738.12... Location of facilities. RUS will make broadband loans for facilities which RUS determines are necessary to... facilities financed with loan funds to be located outside of eligible rural communities. ...

  3. 30 CFR 71.401 - Location of facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Location of facilities. 71.401 Section 71.401... Location of facilities. Bathhouses, change rooms, and sanitary flush toilet facilities shall be in a location convenient for the use of the miners. Where these facilities are designed to serve more than one...

  4. CTF3 Drive Beam Accelerating Structures

    CERN Document Server

    Jensen, E

    2002-01-01

    The 3 GHz drive beam accelerator of the CLIC Test Facility CTF3, currently under construction at CERN, will be equipped with 16 novel SICA (Slotted Iris – Constant Aperture) accelerating structures. The slotted irises couple out the potentially disruptive induced transverse HOM energy to integrated silicon carbide loads (dipole mode Q's below 20). The use of nose cones for detuning allows a constant inner aperture (34 mm). The structures will be 1.2 m long and consist of 34 cells. A first 6 cell prototype structure has been tested successfully up to power levels of 100 MW (nominal: 30 MW), corresponding to surface electric field levels of 180 MV/m.

  5. Work plan, health and safety plan, and quality assurance project plan for hazardous waste removal at the CTF K-1654B underground collection tank

    Energy Technology Data Exchange (ETDEWEB)

    Panter, M.S.; Burman, S.N.; Landguth, D.C.; Uziel, M.S.

    1991-10-01

    The Central Training Facility (CTF), located on Bear Creek Road approximately two miles south of the K-25 Site, is utilized for training security personnel at Martin Marietta Energy Systems, Inc., Oak Ridge, Tennessee. At the request of the CTF staff, this plan has been developed for the removal of the waste contents in the facility's 500-gal septic tank and associated distribution box. The septic tank and distribution box were historically located beneath the K-1654B trailer and adjacent to the K-1654A Indoor Firing Range. Recently, however, the K-1654B trailer was removed to accommodate the objectives of this work plan as well as future construction activities planned at CTF. The purpose of this plan is to develop and assign responsibilities, establish personnel protection requirements and mandatory safety procedures, and provide for contingencies that may arise while operations are being conducted by ORNL/MAD at the CTF K-1654B underground collection tank site. This document addresses requirements of 29 CFR 1910.120, Final Rule, with respect to aspects of health and safety applicable to an underground collection tank waste removal.

  6. 75 FR 19555 - NARA Facility Locations and Hours

    Science.gov (United States)

    2010-04-15

    ..., and 1280 [FDMS Docket NARA-10-0002] RIN 3095-AB66 NARA Facility Locations and Hours AGENCY: National... Regional Records Service Office, and the addition of facility information for the locations of two NARA... facility added. * * * * * PART 1253--LOCATION OF RECORDS AND HOURS OF USE 0 3. The authority citation for...

  7. 30 CFR 75.1712-2 - Location of surface facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Location of surface facilities. 75.1712-2... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Miscellaneous § 75.1712-2 Location of surface facilities. Bathhouses, change rooms, and sanitary toilet facilities shall be in a location...

  8. 10 CFR 75.6 - Facility and location reporting.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Facility and location reporting. 75.6 Section 75.6 Energy... AGREEMENT General Provisions § 75.6 Facility and location reporting. (a) Except where otherwise specified... that its facility or location is required to report under the Safeguards Agreement shall make its...

  9. CTF Void Drift Validation Study

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gosdin, Chris [Pennsylvania State Univ., University Park, PA (United States); Avramova, Maria N. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gergar, Marcus [Pennsylvania State Univ., University Park, PA (United States)

    2015-10-26

    This milestone report is a summary of work performed in support of expansion of the validation and verification (V&V) matrix for the thermal-hydraulic subchannel code, CTF. The focus of this study is on validating the void drift modeling capabilities of CTF and verifying the supporting models that impact the void drift phenomenon. CTF uses a simple turbulent-diffusion approximation to model lateral cross-flow due to turbulent mixing and void drift. The void drift component of the model is based on the Lahey and Moody model. The models are a function of two-phase mass, momentum, and energy distribution in the system; therefore, it is necessary to correctly model the ow distribution in rod bundle geometry as a first step to correctly calculating the void distribution due to void drift.

  10. A Review of the Discrete Facility Location Problem

    Institute of Scientific and Technical Information of China (English)

    WANG Fei; XU Yu; LI Yi-xue

    2006-01-01

    In this paper we attempt to classify discrete facility location problems in the right perspective and propose discrete facility location problems that include: median problems, covering problems, center problems, multi-commodities problems and dynamic problems on the basis of former research by other scholars. We consider vehicle routing location problems, inventory-location problems and hub problems as a recent research field of discrete facility location problems according to literature from the last 10 years.

  11. 7 CFR 1735.91 - Location of facilities.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Location of facilities. 1735.91 Section 1735.91 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF... All Acquisitions and Mergers § 1735.91 Location of facilities. Telephone facilities to be acquired...

  12. The solution of location problems with certain existing facility structures

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1983-01-01

    It is known that in the Euclidean distance case, the optimal minisum location of a new facility in relation to four existing facilities is at the intersection of the two lines joining two pairs of the facilities. The authors extend this concept to minisum problems having any even number of existing...... facilities and characterized by generalized distance norms...

  13. CLIC CTF3 for open days

    CERN Multimedia

    2013-01-01

    (subt french) CLIC – the Compact Linear Collider – is a study for a future accelerator that reaches unprecedented energies for electrons and their antimatter twins, positrons. It uses a novel two-beam acceleration scheme in which the electrons and positrons are propelled to high energy by an additional high current electron beam, the so-called Drive Beam. In order to generate this high current Drive Beam, a long train of electron bunches is accelerated, parts of the train delayed in a Delay Loop and Combiner Rings, and interleaved by transversely deflecting radio-frequency cavities. The CLIC Test Facility CTF3, which is shown in the movie, examines the new technologies envisioned by the CLIC design, in particular the Drive Beam generation and the two-beam acceleration. It is a scaled-down version of the CLIC facility, and it has demonstrated the feasibility of the novel scheme.

  14. CLIC CTF3 for open days

    CERN Multimedia

    CLIC

    2013-01-01

    CLIC – the Compact Linear Collider – is a study for a future accelerator that reaches unprecedented energies for electrons and their antimatter twins, positrons. It uses a novel two-beam acceleration scheme in which the electrons and positrons are propelled to high energy by an additional high current electron beam, the so-called Drive Beam. In order to generate this high current Drive Beam, a long train of electron bunches is accelerated, parts of the train delayed in a Delay Loop and Combiner Rings, and interleaved by transversely deflecting radio-frequency cavities. The CLIC Test Facility CTF3, which is shown in the movie, examines the new technologies envisioned by the CLIC design, in particular the Drive Beam generation and the two-beam acceleration. It is a scaled-down version of the CLIC facility, and it has demonstrated the feasibility of the novel scheme.

  15. 6th July 2010 - United Kingdom Science and Technology Facilities Council W. Whitehorn signing the guest book with Head of International relations F. Pauss, visiting the Computing Centre with Information Technology Department Head Deputy D. Foster, the LHC superconducting magnet test hall with Technology Department P. Strubin,the Centre Control Centre with Operation Group Leader M. Lamont and the CLIC/CTF3 facility with Project Leader J.-P. Delahaye.

    CERN Multimedia

    Teams : M. Brice, JC Gadmer

    2010-01-01

    6th July 2010 - United Kingdom Science and Technology Facilities Council W. Whitehorn signing the guest book with Head of International relations F. Pauss, visiting the Computing Centre with Information Technology Department Head Deputy D. Foster, the LHC superconducting magnet test hall with Technology Department P. Strubin,the Centre Control Centre with Operation Group Leader M. Lamont and the CLIC/CTF3 facility with Project Leader J.-P. Delahaye.

  16. A localization property for facility location problems with arbitrary norms

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1988-01-01

    In an earlier article (1983), the authors showed that, for facilities-location problems characterized by generalized distance norms and any even number of existing facilities, the optimal location of the new facility is at the intersection of the lines joining the pairs of facilities if these lines...... intersect at a single point. In this article the authors extend this concept to show that, for a more general class of problems, the optimal location is one of a set of points which is specified by the existing facilities...

  17. A localization property for facility location problems with arbitrary norms

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1988-01-01

    In an earlier article (1983), the authors showed that, for facilities-location problems characterized by generalized distance norms and any even number of existing facilities, the optimal location of the new facility is at the intersection of the lines joining the pairs of facilities if these lines...... intersect at a single point. In this article the authors extend this concept to show that, for a more general class of problems, the optimal location is one of a set of points which is specified by the existing facilities...

  18. Spatial interaction models facility location using game theory

    CERN Document Server

    D'Amato, Egidio; Pardalos, Panos

    2017-01-01

    Facility location theory develops the idea of locating one or more facilities by optimizing suitable criteria such as minimizing transportation cost, or capturing the largest market share. The contributions in this book focus an approach to facility location theory through game theoretical tools highlighting situations where a location decision is faced by several decision makers and leading to a game theoretical framework in non-cooperative and cooperative methods. Models and methods regarding the facility location via game theory are explored and applications are illustrated through economics, engineering, and physics. Mathematicians, engineers, economists and computer scientists working in theory, applications and computational aspects of facility location problems using game theory will find this book useful.

  19. CTF Validation and Verification Manual

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Blyth, Taylor S. [Pennsylvania State Univ., University Park, PA (United States); Dances, Christopher A. [Pennsylvania State Univ., University Park, PA (United States); Magedanz, Jeffrey W. [Pennsylvania State Univ., University Park, PA (United States); Jernigan, Caleb [Holtec International, Marlton, NJ (United States); Kelly, Joeseph [U.S. Nuclear Regulatory Commission (NRC), Rockville, MD (United States); Toptan, Aysenur [North Carolina State Univ., Raleigh, NC (United States); Gergar, Marcus [Pennsylvania State Univ., University Park, PA (United States); Gosdin, Chris [Pennsylvania State Univ., University Park, PA (United States); Avramova, Maria [Pennsylvania State Univ., University Park, PA (United States); Palmtag, Scott [Core Physics, Inc., Cary, NC (United States); Gehin, Jess C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-05-25

    Coolant-Boiling in Rod Arrays- Two Fluids (COBRA-TF) is a Thermal/Hydraulic (T/H) simulation code designed for Light Water Reactor (LWR) analysis. It uses a two-fluid, three-field (i.e. fluid film, fluid drops, and vapor) modeling approach. Both sub-channel and 3D Cartesian forms of nine conservation equations are available for LWR modeling. The code was originally developed by Pacific Northwest Laboratory in 1980 and has been used and modified by several institutions over the last several decades. COBRA-TF is also used at the Pennsylvania State University (PSU) by the Reactor Dynamics and Fuel Management Group (RDFMG), and has been improved, updated, and subsequently became the PSU RDFMG version of COBRA-TF (CTF). One part of the improvement process includes validating the methods in CTF. This document seeks to provide a certain level of certainty and confidence in the predictive capabilities of the code for the scenarios it was designed to model--rod bundle geometries with operating conditions that are representative of prototypical Pressurized Water Reactor (PWR)s and Boiling Water Reactor (BWR)s in both normal and accident conditions. This is done by modeling a variety of experiments that simulate these scenarios and then presenting a qualitative and quantitative analysis of the results that demonstrates the accuracy to which CTF is capable of capturing specific quantities of interest.

  20. CTF3 Design Report Preliminary Phase

    CERN Document Server

    Allard, D; Bernard, M; Bertuzzi, J P; Bienvenu, G; Bonzano, R; Bossart, Rudolf; Braun, H; Bravin, Enrico; Borburgh, J; Buttkus, J; Chazarenc, E; Chaput, R; Chohan, V; Cloye, J J; Corsini, R; Coudert, G; Damiani, M; Deghaye, S; Delahaye, J P; Di Maio, F; Dobers, T; Dubief, P; Dupuy, B; Durieu, L; Ferrari, A; Garvey, Terence; Geschonke, Günther; Hansen, J; Hellgren, H; Hourican, M; Lamidon, M; Le Duff, J; Lefèvre, T; Lewis, J H; Lindroos, J; Mahner, E; McMonagle, G; Monteiro, J; Mourier, J; Mouton, B; Odier, P; Otto, T; Pearce, P; Pittin, R; Poehler, M; Potier, J P; Raich, U; Rettig, M; Rinolfi, Louis; Risselada, Thys; Riva, R; Rossat, G; Royer, P; Sermeus, L; Setas, K; Simonet, G; Sladen, Jonathan P H; Søby, L; Tanner, L; Tecker, F A; Thomi, J C; Wilson, Ian H; Yvon, G

    2001-01-01

    The design of CLIC is based on a two-beam scheme, where the short pulses of high power 30 GHz RF are extracted from a drive beam running parallel to the main beam. The 3rd generation CLIC Test Facility (CTF3) will demonstrate the generation of the drive beam with the appropriate time structure, the extraction of 30 GHz RF power from this beam, as well as acceleration of a probe beam with 30 GHz RF cavities. The project makes maximum use of existing equipment and infrastructure of the LPI complex, which became available after the closure of LEP. In the first stage of the project, the "Preliminary Phase", the existing LIL linac and the EPA ring, both modified to suit the new requirements, are used to investigate the technique of frequency multiplication by means of interleaving bunches from subsequent trains. This report describes the design of this phase.

  1. The CLIC feasibility demonstration in CTF3

    CERN Document Server

    Skowroński, P K; Bettoni, S; Constance, B; Corsini, R; Divall Csatari, M; Dabrowski, A E; Doebert, S; Dubrovskiy, A; Kononenko, O; Olvegaard, M; Persson, T; Rabiller, A; Tecker, F; Farabolini, W; Lillestol, R L; Adli, E; Palaia, A; Ruber, R

    2011-01-01

    The objective of the CLIC Test Facility CTF3 is to demonstrate the feasibility issues of the CLIC two-beam technology: the efficient generation of a very high current drive beam, used as the power source to accelerate the main beam to multi-TeV energies with gradients of over 100 MeV/m, and stable drive beam deceleration. Results of successful beam acceleration with over 100 MeV/m energy gain are shown. Measurements of drive beam deceleration over a chain of Power Extraction Structures (PETS) are presented. The achieved RF power levels, the stability of the power production and of the deceleration are discussed. Finally, we give an overview of the remaining issues to be addressed by the end of 2011.

  2. The solution of location problems with certain existing facility structures

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1983-01-01

    It is known that in the Euclidean distance case, the optimal minisum location of a new facility in relation to four existing facilities is at the intersection of the two lines joining two pairs of the facilities. The authors extend this concept to minisum problems having any even number of existi...

  3. 14 CFR 21.43 - Location of manufacturing facilities.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Location of manufacturing facilities. 21.43... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.43 Location of manufacturing facilities. Except as provided in § 21.29, the Administrator does not issue a type certificate if the...

  4. 47 CFR 3.42 - Location of processing facility.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Location of processing facility. 3.42 Section 3.42 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL AUTHORIZATION AND ADMINISTRATION OF... Location of processing facility. Settlement of maritime mobile and maritime mobile-satellite service...

  5. Capacitated Dynamic Facility Location Problem Based on Tabu Search Algorithm

    Institute of Scientific and Technical Information of China (English)

    KUANG Yi-jun; ZHU Ke-jun

    2007-01-01

    Facility location problem is a kind of NP-Hard combinational problem. Considering ever-changing demand sites, demand quantity and releasing cost, we formulate a model combining tabu search and FCM (fuzzy clustering method) to solve the eapacitated dynamic facility location problem. Some results are achieved and they show that the proposed method is effective.

  6. Intertemporal and Spatial Location of Disposal Facilities

    NARCIS (Netherlands)

    Andre, F.J.; Velasco, F.; Gonzalez, L.

    2004-01-01

    Optimal capacity and location of a sequence of land.lls are studied, and the interactions between both decisions are pointed out.The decision capacity has some spatial implications, because it a.ects the feasible region for the rest of land.lls, and some temporal implications, because the capacity

  7. Intertemporal and spatial location of disposal facilities

    OpenAIRE

    Andre, F.J.; Velasco, F; Gonzalez, L.

    2009-01-01

    The optimal capacity and location of a sequence of landfills are studied, and the interactions between both decisions are pointed out. Deciding the capacity of a landfill has some spatial implications, because it effects the feasible region for the rest of the landfills, and some temporal implications because the capacity determines the lifetime of the landfill and hence the instant of time where the next landfills will need to be constructed. Some general mathematical properties of the solut...

  8. Beam stability at CTF3

    CERN Document Server

    Persson, T

    2012-01-01

    The two-beam acceleration tested at CTF3 imposes very tight tolerances on the drive beam stability. A description of the specialized monitoring tool developed to identify the drifts and jitter in the machine is presented. It compares all the relevant signals in an on-line manner to help the operator to identify drifts and to log data for off-line analysis. The main sources for the drifts of the drive beam have been identified and their causes are described. A feedback applied to the RF was implemented to reduce the effects. It works by changing the waveform for the pulse compression to compensate for the drifts.

  9. CTF User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Avramova, Maria [Pennsylvania State Univ., University Park, PA (United States); Blyth, Taylor S. [Pennsylvania State Univ., University Park, PA (United States); Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-08-01

    This document describes how to make a CTF input deck. A CTF input deck is organized into Card Groups and Cards. A Card Group is a collection of Cards. A Card is de ned as a line of input. Each Card may contain multiple data. A Card is terminated by making a new line.

  10. Congestion Service Facilities Location Problem with Promise of Response Time

    Directory of Open Access Journals (Sweden)

    Dandan Hu

    2013-01-01

    Full Text Available In many services, promise of specific response time is advertised as a commitment by the service providers for the customer satisfaction. Congestion on service facilities could delay the delivery of the services and hurts the overall satisfaction. In this paper, congestion service facilities location problem with promise of response time is studied, and a mixed integer nonlinear programming model is presented with budget constrained. The facilities are modeled as M/M/c queues. The decision variables of the model are the locations of the service facilities and the number of servers at each facility. The objective function is to maximize the demands served within specific response time promised by the service provider. To solve this problem, we propose an algorithm that combines greedy and genetic algorithms. In order to verify the proposed algorithm, a lot of computational experiments are tested. And the results demonstrate that response time has a significant impact on location decision.

  11. Recycling Facilities - Mine Drainage Treatment/Land Recycling Project Locations

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Mine Drainage Treatment/Land Reclamation Locations are clean-up projects that are working to eliminate some form of abandoned mine. The following sub-facility types...

  12. 14 CFR 21.137 - Location of manufacturing facilities.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Location of manufacturing facilities. 21.137 Section 21.137 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... manufacturing facilities. The Administrator does not issue a production certificate if the...

  13. Parallel Approximation Algorithms for Facility-Location Problems

    OpenAIRE

    Blelloch, Guy E.; Tangwongsan, Kanat

    2010-01-01

    This paper presents the design and analysis of parallel approximation algorithms for facility-location problems, including $\\NC$ and $\\RNC$ algorithms for (metric) facility location, $k$-center, $k$-median, and $k$-means. These problems have received considerable attention during the past decades from the approximation algorithms community, concentrating primarily on improving the approximation guarantees. In this paper, we ask, is it possible to parallelize some of the beautiful results from...

  14. 33 CFR 137.65 - Visual inspections of the facility, the real property on which the facility is located, and...

    Science.gov (United States)

    2010-07-01

    ... facility, the real property on which the facility is located, and adjoining properties. 137.65 Section 137... inspections of the facility, the real property on which the facility is located, and adjoining properties. (a... the facility and the real property on which the facility is located, and the improvements at the...

  15. On a rational stopping rule for facilities location algorithms

    DEFF Research Database (Denmark)

    Juel, Henrik

    1984-01-01

    In the multifacility location problem, a number of new facilities are to be located so as to minimize a sum of weighted distances. Love and Yeong (1981) developed a lower bound on the optimal value for use in deciding when to stop an iterative solution procedure. The authors develop a stronger...

  16. On a rational stopping rule for facilities location algorithms

    DEFF Research Database (Denmark)

    Juel, Henrik

    1984-01-01

    In the multifacility location problem, a number of new facilities are to be located so as to minimize a sum of weighted distances. Love and Yeong (1981) developed a lower bound on the optimal value for use in deciding when to stop an iterative solution procedure. The authors develop a stronger...

  17. The p-median Facility Location Problem and Solution Approaches

    Directory of Open Access Journals (Sweden)

    Mehmet BASTI

    2012-05-01

    Full Text Available In today’s globalized and increasingly competitive environment, organizations’ need to implement successful strategies for supply chain management has become indispensable. Transportation costs within the supply chain comprise an important part of the organizations’ expenses. For this reason, the strategic selection of location is an issue that directly affects supply chain performance and costs. At this stage, it becomes very important to apply the latest and the best methods to the facility location problem. The focus of this study is the p-median problem and its solution techniques, one of the location allocation problems aimed at minimizing the costs arising from shipments between facilities and demand points.

  18. On Pure and (approximate) Strong Equilibria of Facility Location Games

    DEFF Research Database (Denmark)

    Hansen, Thomas Dueholm; Telelis, Orestis A.

    2008-01-01

    We study social cost losses in Facility Location games, where n selfish agents install facilities over a network and connect to them, so as to forward their local demand (expressed by a non-negative weight per agent). Agents using the same facility share fairly its installation cost, but every...... networks we prove upper and lower bounds on PoS, while an O(ln n) upper bound implied by previous work is tight for non-metric networks. We also prove a constant upper bound for the SPoA of metric networks when strong equilibria exist. For the weighted game on general networks we prove existence of e...

  19. Uncapacitated facility location problem with self-serving demands

    Directory of Open Access Journals (Sweden)

    E Monabbati

    2013-12-01

    Full Text Available In classical uncapacitated facility location problems (UFLP the goal is to satisfy requirements of some demand points by setting up some servers, among potential facility locations, such that the total cost including service costs and fixed costs are minimized. In this paper a generalization of UFLP is considered in which some demand points, called self-serving, could be served exclusively by a new server at that point. Numerical experiments show that near optimal solutions are achieved by the proposed method.

  20. A competitive facility location in a closed form supply chain

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Mohammadi

    2014-06-01

    Full Text Available This paper studies capacitated facility location problem by considering green management perspectives. The proposed study considers reverse logistic problem as an alternative strategy for facility location in an attempt to take care of environmental characteristics. The resulted problem is formulated as mixed integer programming and it is classified as an NP-Hard problem. Therefore, a Lagrangian relaxation methodology is presented to reduce the complexity of the proposed problem and the solution has been implemented for some instances to examine the performance of the proposed study.

  1. A Probabilistic, Facility-Centric Approach to Lightning Strike Location

    Science.gov (United States)

    Huddleston, Lisa L.; Roeder, William p.; Merceret, Francis J.

    2012-01-01

    A new probabilistic facility-centric approach to lightning strike location has been developed. This process uses the bivariate Gaussian distribution of probability density provided by the current lightning location error ellipse for the most likely location of a lightning stroke and integrates it to determine the probability that the stroke is inside any specified radius of any location, even if that location is not centered on or even with the location error ellipse. This technique is adapted from a method of calculating the probability of debris collisionith spacecraft. Such a technique is important in spaceport processing activities because it allows engineers to quantify the risk of induced current damage to critical electronics due to nearby lightning strokes. This technique was tested extensively and is now in use by space launch organizations at Kennedy Space Center and Cape Canaveral Air Force Station. Future applications could include forensic meteorology.

  2. 76 FR 68170 - Instructions for Implementing Sustainable Locations for Federal Facilities in Accordance With...

    Science.gov (United States)

    2011-11-03

    ... Locations for Federal Facilities in Accordance With Executive Order 13514 AGENCY: Council on Environmental Quality. ACTION: Notice of availability of sustainable locations for Federal facilities implementing... Federal agencies for integrating sustainable facility location decision-making principles into agency...

  3. Site survey for optimum location of Optical Communication Experimental Facility

    Science.gov (United States)

    1968-01-01

    Site survey was made to determine the optimum location for an Optical Communication Experimental Facility /OCEF/ and to recommend several sites, graded according to preference. A site was desired which could perform two-way laser communication with a spacecraft and laser tracking with a minimum of interruption by weather effects.

  4. Linear facility location in three dimensions - Models and solution methods

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2002-01-01

    We consider the problem of locating a line or a line segment in three-dimensional space, such that the sum of distances from the facility represented by the line (segment) to a given set of points is minimized. An example is planning the drilling of a mine shaft, with access to ore deposits through...

  5. Linear facility location in three dimensions - Models and solution methods

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2002-01-01

    We consider the problem of locating a line or a line segment in three-dimensional space, such that the sum of distances from the facility represented by the line (segment) to a given set of points is minimized. An example is planning the drilling of a mine shaft, with access to ore deposits through...

  6. Fault-tolerant Concave Facility Location Problem with Uniform Requirements

    Institute of Scientific and Technical Information of China (English)

    Xing WANG; Da-Chuan XU; Zheng-Hai HUANG

    2012-01-01

    In this paper,we consider the fault-tolerant concave facility location problem (FTCFL) with uniform requirements. By investigating the structure of the FTCFL,we obtain a modified dual-fitting bifactor approximation algorithm.Combining the scaling and greedy argumentation technique,the approximation factor is proved to be 1.52.

  7. A hybrid nested partitions algorithm for banking facility location problems

    KAUST Repository

    Xia, Li

    2010-07-01

    The facility location problem has been studied in many industries including banking network, chain stores, and wireless network. Maximal covering location problem (MCLP) is a general model for this type of problems. Motivated by a real-world banking facility optimization project, we propose an enhanced MCLP model which captures the important features of this practical problem, namely, varied costs and revenues, multitype facilities, and flexible coverage functions. To solve this practical problem, we apply an existing hybrid nested partitions algorithm to the large-scale situation. We further use heuristic-based extensions to generate feasible solutions more efficiently. In addition, the upper bound of this problem is introduced to study the quality of solutions. Numerical results demonstrate the effectiveness and efficiency of our approach. © 2010 IEEE.

  8. Sufficient conditions for optimal facility locations to coincide

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1980-01-01

    In some cases multifacility location problems may be solved by verifying a few simple inequalities involving the interfacility weights. The authors develop certain inequalities which are sufficient conditions for optimality in some multifacility problems. In the problems considered, distances are...... are represented by a symmetric metric and there are no constraints on the location of the new facilities......In some cases multifacility location problems may be solved by verifying a few simple inequalities involving the interfacility weights. The authors develop certain inequalities which are sufficient conditions for optimality in some multifacility problems. In the problems considered, distances...

  9. A facility location model for socio-environmentally responsible decision-making

    National Research Council Canada - National Science Library

    Ansbro, Dominic; Wang, Qing

    2013-01-01

    .... The model presented considers a network of suppliers, manufacturing facilities, customers, scrap recyclers, general recycling facilities and landfill sites and makes facility location and allocation...

  10. Development and Assessment of CTF for Pin-resolved BWR Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K [ORNL; Wysocki, Aaron J [ORNL; Collins, Benjamin S [ORNL; Avramova, Maria [North Carolina State University (NCSU), Raleigh; Gosdin, Chris [Pennsylvania State University

    2017-01-01

    CTF is the modernized and improved version of the subchannel code, COBRA-TF. It has been adopted by the Consortium for Advanced Simulation for Light Water Reactors (CASL) for subchannel analysis applications and thermal hydraulic feedback calculations in the Virtual Environment for Reactor Applications Core Simulator (VERA-CS). CTF is now jointly developed by Oak Ridge National Laboratory and North Carolina State University. Until now, CTF has been used for pressurized water reactor modeling and simulation in CASL, but in the future it will be extended to boiling water reactor designs. This required development activities to integrate the code into the VERA-CS workflow and to make it more ecient for full-core, pin resolved simulations. Additionally, there is a significant emphasis on producing high quality tools that follow a regimented software quality assurance plan in CASL. Part of this plan involves performing validation and verification assessments on the code that are easily repeatable and tied to specific code versions. This work has resulted in the CTF validation and verification matrix being expanded to include several two-phase flow experiments, including the General Electric 3 3 facility and the BWR Full-Size Fine Mesh Bundle Tests (BFBT). Comparisons with both experimental databases is reasonable, but the BFBT analysis reveals a tendency of CTF to overpredict void, especially in the slug flow regime. The execution of these tests is fully automated, analysis is documented in the CTF Validation and Verification manual, and the tests have become part of CASL continuous regression testing system. This paper will summarize these recent developments and some of the two-phase assessments that have been performed on CTF.

  11. On Pure and (approximate) Strong Equilibria of Facility Location Games

    CERN Document Server

    Hansen, Thomas Dueholm

    2008-01-01

    We study social cost losses in Facility Location games, where n selfish agents install facilities over a network and connect to them, so as to forward their local demand (expressed by a non-negative weight per agent). Agents using the same facility share fairly its installation cost, but every agent pays individually a (weighted) connection cost to the chosen location. We study the Price of Stability (PoS) of pure Nash equilibria and the Price of Anarchy of strong equilibria (SPoA), that generalize pure equilibria by being resilient to coalitional deviations. A special case of recently studied network design games, Facility Location merits separate study as a classic model with numerous applications and individual characteristics: our analysis for unweighted agents on metric networks reveals constant upper and lower bounds for the PoS, while an O(ln n) upper bound implied by previous work is tight for non-metric networks. Strong equilibria do not always exist, even for the unweighted metric case. For this cas...

  12. A Capacitated Facility Location Approach for the Tanker Employment Problem

    Science.gov (United States)

    2005-03-01

    Depot (MD) Vehicle Routing Problem (VRP) ......................................... 14 2.5 Capacitated Facility Location Problem (CFLP) with Sole...service receiver groups. In this sense the problem can be viewed as a multi-depot vehicle routing problem . Anchor points are two stationary points...for future research. 2.4 Multi-Depot (MD) Vehicle Routing Problem (VRP) Another approach to the Tanker Employment Problem is to model it as a VRP

  13. The p-median Facility Location Problem and Solution Approaches

    OpenAIRE

    BASTI, MEHMET

    2012-01-01

    In today’s globalized and increasingly competitive environment, organizations’ need to implement successful strategies for supply chain management has become indispensable. Transportation costs within the supply chain comprise an important part of the organizations’ expenses. For this reason, the strategic selection of location is an issue that directly affects supply chain performance and costs. At this stage, it becomes very important to apply the latest and the best methods to the facility...

  14. 40 CFR 267.18 - What are the standards for selecting the location of my facility?

    Science.gov (United States)

    2010-07-01

    ... the location of my facility? 267.18 Section 267.18 Protection of Environment ENVIRONMENTAL PROTECTION... FACILITIES OPERATING UNDER A STANDARDIZED PERMIT General Facility Standards § 267.18 What are the standards for selecting the location of my facility? (a) You may not locate portions of new facilities where...

  15. Location, use, and locational efficiency of health facilities in a Madras neighbourhood.

    Science.gov (United States)

    Kumaran, V V

    1983-01-01

    The present paper has two related aims: an attempt to measure locational efficiency of health facilities in a Madras neighbourhood - Alandur - through an analysis of use patterns obtained from a questionnaire study, and an application of two significant methods on problems relating to organisation of health services - set covering reasoning and maximal covering location method. Some major conclusions of the two related analyses are: - Generally use declines with distance. However, beyond the eleventh distance zone, the use increases sharply, only to decrease after the fourteenth distance zone, the number of visits attributable to quality services at locations in these distance zones. - Among the variables determining the use patterns, distance is most important, followed by cost of treatment, the quality care, nature of facility and its availability. - Set covering method yielded 5 potential health location sites which proved to be efficient in both population coverage and maximum time distances of five and ten minutes /maximal covering location method/. Two alternative sets identified by set covering method proved to be inefficient on both population and distance counts when maximal covering method was applied.

  16. Design of the Modulator the CTF3 Tail Clipper Kicker

    CERN Document Server

    Barnes, M J; Ravida, G; Ueda, A

    2007-01-01

    The goal of the present CLIC Test Facility (CTF3) is to demonstrate the technical feasibility of specific key issues in the CLIC scheme. The extracted beam from the combiner ring (CR), of 35 A in magnitude and 140 ns duration, is sent to the new CLic EXperimental area (CLEX) facility. A Tail Clipper (TC) is required, in the CR to CLEX transfer line, to allow the duration of the extracted beam pulse to be adjusted. It is proposed to use a stripline kicker for the tail clipper, with each of the deflector plates driven to equal but opposite potential. The tail clipper kick must have a fast rise-time, of not more than 5 ns, in order to minimize uncontrolled beam loss. Several different options are being investigated to meet the demanding specifications for the modulator of the tail clipper. This paper discusses options considered for the fast, high voltage, semiconductor switches and shows results of initial tests on the switches.

  17. In-situ Vibration Measurements of the CTF2 Quadrupoles

    CERN Document Server

    Coosemans, Williame

    2004-01-01

    The Compact LInear Collider (CLIC), presently under study at the European Organization for Nuclear Research (CERN), aims at colliding high energy â€ワnanobeams” at a luminosity of 1035 cm-2s-1. Vibrations of the lattice elements, if not properly corrected, can result in a loss in performance by creating both unacceptable emittance growth in the linear accelerator and relative beam-beam offsets at the interaction point. Of particular concern are the vibrations induced by the accelerator environment. For example, the circulating water used to cool the lattice quadrupoles will increase magnet vibration levels. In the framework of the CLIC stability study, in-situ measurements of quadrupole vibrations have been performed at the CLIC Test Facility 2 (CTF2) with all accelerator equipment switched on. Since the CTF2 quadrupoles and their alignment support structures are realistic prototypes of those to be used in the CLIC linac, the measurements provide a realistic estimate of the CLIC magnet vibrations in a...

  18. 14 CFR 145.105 - Change of location, housing, or facilities.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Change of location, housing, or facilities..., Materials, and Data § 145.105 Change of location, housing, or facilities. (a) A certificated repair station... certificated repair station must operate while it is changing its location, housing, or facilities. ...

  19. 7 CFR 1735.13 - Location of facilities and service for nonrural subscribers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Location of facilities and service for nonrural...-TELECOMMUNICATIONS PROGRAM Loan Purposes and Basic Policies § 1735.13 Location of facilities and service for nonrural... location. (b) To the greatest extent practical, loans are limited to providing telephone facilities that...

  20. 41 CFR 301-74.5 - How should we select a location and a facility?

    Science.gov (United States)

    2010-07-01

    ... location and a facility? 301-74.5 Section 301-74.5 Public Contracts and Property Management Federal Travel... Agency Responsibilities § 301-74.5 How should we select a location and a facility? Site selection is a... location and the specific facility(ies) selected. In determining the best site in the interest of the...

  1. 6th CTF3 Collaboration Meeting

    CERN Document Server

    2000-01-01

    The sixth CTF3 collaboration meeting was held at CERN from the 1st to the 2nd November 2000. This meeting was devoted to the CTF3 combiner ring, delay loop and transfer lines, with the participation of members of the CLIC study group at CERN and of collaborators from INFN-Frascati. The CTF3 status has been summarized by the project leader, and several members of the INFN-Frascati group have presented an overview of the design activity of the different components. Working group sessions have been held on beam optics, on diagnostics and equipment and on RF deflectors. The main conclusions from the working groups have been reported at the end of the meeting. Issues that have been addressed include prototype design and construction (RF deflectors, path-length tuning wigglers, extraction kicker and vacuum chamber sections) and deadlines for component specifications. The impedance budget for the ring, delay loop and transfer lines, its impact on the choice of beam-position monitors and the problem of beam stability...

  2. Measuring the Bunch Frequency Multiplication at CTF3

    CERN Document Server

    Bettoni, S; Corsini, R; Dabrowski, A; Doebert, S; Egger, D; Ferrari, A; Lefevre, T; Rabiller, A; Skowronski, PK; Soby, L; Tecker, F; Welsch, CP

    2010-01-01

    The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration to test the feasibility of the proposed Compact Linear Collider (CLIC) drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a delay loop and a combiner ring, in order to transform the initial bunch frequency of 1.5 GHz from the LINAC to a final bunch frequency of 12 GHz. The optimization procedure relies on several steps. The active length of each ring is carefully adjusted to within less than millimetre accuracy using a wiggler magnet. The transverse optics of the machine must be set up in a way to ensure beam isochronicity. Diagnostics based on optical Streak camera and RF power measurements have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents their performance and recent measurements

  3. Monte Carlo Simulations of Beam Losses in the Test Beam Line of CTF3

    CERN Document Server

    Nebot Del Busto, E; Branger, E; Holzer, E B; Doebert, S; Lillestol, R L; Welsch, C P

    2013-01-01

    The Test Beam Line (TBL) of the CLIC Test Facility 3 (CTF3) aims to validate the drive beam deceleration concept of CLIC, in which the RF power requested to boost particles to multi-TeV energies is obtained via deceleration of a high current and low energy drive beam (DB). Despite a TBL beam energy (150-80 MeV) significantly lower than the minimum nominal energy of the CLIC DB (250 MeV), the pulse time structure of the TBL provides the opportunity to measure beam losses with CLIC-like DB timing conditions. In this contribution, a simulation study on the detection of beam losses along the TBL for the commissioning of the recently installed beam loss monitoring system is presented. The most likely loss locations during stable beam conditions are studied by considering the beam envelope defined by the FODO lattice as well as the emittance growth due to the deceleration process. Moreover, the optimization of potential detector locations is discussed. Several factors are considered, namely: the distance to the bea...

  4. 41 CFR 109-40.112 - Transportation factors in the location of Government facilities.

    Science.gov (United States)

    2010-07-01

    ... in the location of Government facilities. 109-40.112 Section 109-40.112 Public Contracts and Property... 40.1-General Provision § 109-40.112 Transportation factors in the location of Government facilities... prior to the selection of new site locations and during the planning and construction phases in the...

  5. A bicriteria model for locating a semi-desirable facility in

    DEFF Research Database (Denmark)

    Juel, Henrik; Brimberg, Jack

    1998-01-01

    We consider the problem of locating a facility in the plane. Customers want the facility to be close to obtain cheaply the service offered by it. But customers also want the facility to be far away to avoid the pollution from it. We model the situation using two criteria: One is the well-known mi......, with weights adding to one. We outline a method for determining the efficient frontier of facility locations, and provide an illustrative numerical example....

  6. Experimental Verifiction of the CLIC two beam Acceleration Technology in CTF3

    CERN Document Server

    Constance, B; Barranco, J; Corsini, R; Doebert, S; Dubrovskiy, A; Skowronski, P; Tecker, F; Farabolini, W; Persson, T; Lillestol, R; Ikarios, E; Jacewicz, M; Palaia, A; Ruber, R

    2013-01-01

    The Compact Linear Collider international collaboration is pursuing an extensive R&D program towards a multi- TeV electron-positron collider. In particular, the development of two-beam acceleration technology is the focus of the CLIC test facility CTF3. In this paper we summarise the most recent results obtained at CTF3: the results of the studies on the drive beam generation are presented, the achieved two beam acceleration performance is reported and the measured breakdown rates and related observations are summarised. The stability of deceleration process performed over 12 subsequent modules and the comparison of the obtained results with the theoretical expectations are discussed. We also outline and discuss the future experimental program.

  7. Design of Phase Feed Forward System in CTF3 and Performance of Fast Beam Phase Monitors

    CERN Document Server

    Skowronski, P K; Ghigo, A; Marcellini, F; Burrows, PN; Christian, GB; Perry, C; Gerbershagen, A; Roberts, J; Ikarios, E

    2013-01-01

    The CLIC two beam acceleration technology requires a drive beam phase stability better than 0.3 deg rms at 12 GHz, corresponding to a timing stability below 50 fs rms. For this reason the CLIC design includes a phase stabilization feed-forward system. It relies on precise beam phase measurements and their subsequent correction in a chicane with the help of fast kickers. A prototype of such a system is being installed in the CLIC Test Facility CTF3. In this paper its design and implementation is described in detail. Additionally, the performance of the precision phase monitor prototypes installed at the end of the CTF3 linac, as measured with the drive beam, is presented.

  8. Aggregation and non aggregation techniques for large facility location problems: A survey

    Directory of Open Access Journals (Sweden)

    Irawan Chandra Ade

    2015-01-01

    Full Text Available A facility location problem is concerned with determining the location of some useful facilities in such a way so to fulfil one or a few objective functions and constraints. We survey those problems where, in the presence of a large number of customers, some form of aggregation may be required. In addition, a review on conditional location problems where some (say q facilities already exist in the study area is presented.

  9. A simulation based research on chance constrained programming in robust facility location problem

    Science.gov (United States)

    Kaijun, Leng; Wen, Shi; Guanghua, Song; Lin, Pan

    2017-03-01

    Since facility location decisions problem include long-term character and potential parameter variations, it is important to consider uncertainty in its modeling. This paper examines robust facility location problem considering supply uncertainty, in which we assume the supply of the facility in the actual operation is not equal to the supply initially established, the supply is subject to random fluctuation. The chance constraints are introduced when formulating the robust facility location model to make sure the system operate properly with a certain probability while the supply fluctuates. The chance constraints are approximated safely by using Hoeffding's inequality and the problem is transformed to a general deterministic linear programming. Furthermore, how the facility location cost change with confidence level is investigated through a numerical example. The sensitivity analysis is conducted for important parameters of the model and we get the main factors that affect the facility location cost.

  10. On models for continuous facility location with partial coverage

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Körner, Mark-Christoph

    2014-01-01

    This paper presents a new concept of partial coverage distance, where demand points within a given threshold distance of a new facility are covered in the traditional sense, while non-covered demand points are penalized an amount proportional to their distance to the covered region. Two single fa...

  11. Update on beam loss monitoring at CTF3 for CLIC

    CERN Document Server

    Devlin, L J; Effinger, E; Holzer, E B; del Busto, E N; Mallows, S; Branger, E

    2013-01-01

    The primary role of the beam loss monitoring (BLM) system for the compact linear collider (CLIC) study is to work within the machine protection system. Due to the size of the CLIC facility, a BLM that covers large distances along the beam line is highly desirable, in particular for the CLIC drive beam decelerators, which would alternatively require some ~40,000 localised monitors. Therefore, an optical fibre BLM system is currently under investigation which can cover large sections of beam line at a time. A multimode fibre has been installed along the Test Beam Line at the CLIC test facility (CTF3) where the detection principle is based on the production of Cherenkov photons within the fibre resulting from beam loss and their subsequent transport along the fibre where they are then detected at the fibre ends using silicon photomultipliers. Several additional monitors including ACEMs, PEP-II and diamond detectors have also been installed. In this contribution the first results from the BLMs are presented, comp...

  12. Sufficient conditions for optimal facility locations to coincide

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1980-01-01

    In some cases multifacility location problems may be solved by verifying a few simple inequalities involving the interfacility weights. The authors develop certain inequalities which are sufficient conditions for optimality in some multifacility problems. In the problems considered, distances are...

  13. 30 CFR 75.1712-8 - Application for waiver of location requirements for underground sanitary facilities.

    Science.gov (United States)

    2010-07-01

    ... underground sanitary facilities. Applications for waivers of the location requirements of § 75.1712-6 shall be... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Application for waiver of location requirements for underground sanitary facilities. 75.1712-8 Section 75.1712-8 Mineral Resources MINE SAFETY AND...

  14. An approximation algorithm for a facility location problem with stochastic demands

    NARCIS (Netherlands)

    Bumb, A.F.; van Ommeren, Jan C.W.

    2004-01-01

    In this article we propose, for any $\\epsilon>0$, a $2(1+\\epsilon)$-approximation algorithm for a facility location problem with stochastic demands. This problem can be described as follows. There are a number of locations, where facilities may be opened and a number of demand points, where requests

  15. 30 CFR 57.6131 - Location of explosive material storage facilities.

    Science.gov (United States)

    2010-07-01

    ... NONMETAL MINES Explosives Storage-Surface Only § 57.6131 Location of explosive material storage facilities... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Location of explosive material storage facilities. 57.6131 Section 57.6131 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF...

  16. 14 CFR 21.309 - Location of or change to manufacturing facilities.

    Science.gov (United States)

    2010-01-01

    ..., and Appliances § 21.309 Location of or change to manufacturing facilities. (a) An applicant may obtain... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Location of or change to manufacturing facilities. 21.309 Section 21.309 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

  17. 14 CFR 21.122 - Location of or change to manufacturing facilities.

    Science.gov (United States)

    2010-01-01

    ... § 21.122 Location of or change to manufacturing facilities. (a) An applicant may obtain a production... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Location of or change to manufacturing facilities. 21.122 Section 21.122 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

  18. An improved Lagrangian relaxation and dual ascent approach to facility location problems

    DEFF Research Database (Denmark)

    Jörnsten, Kurt; Klose, Andreas

    2016-01-01

    method for optimizing both the semi-Lagrangian dual function as well as its simplified form for the case of a generic discrete facility location problem and apply the method to the uncapacitated facility location problem. Our computational results show that the method generally only requires a very few...

  19. 30 CFR 56.6131 - Location of explosive material storage facilities.

    Science.gov (United States)

    2010-07-01

    ... MINES Explosives Storage § 56.6131 Location of explosive material storage facilities. (a) Storage... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Location of explosive material storage facilities. 56.6131 Section 56.6131 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF...

  20. An approximation algorithm for a facility location problem with stochastic demands

    NARCIS (Netherlands)

    Bumb, A.F.; Ommeren, van J.C.W.

    2004-01-01

    In this article we propose, for any $\\epsilon>0$, a $2(1+\\epsilon)$-approximation algorithm for a facility location problem with stochastic demands. This problem can be described as follows. There are a number of locations, where facilities may be opened and a number of demand points, where requests

  1. Away-Day: a Review of the Preparation of the CTF3 Design

    CERN Document Server

    1998-01-01

    Schedule: The route to CLIC and objectives of the brainstorming session (moderator: J.P. Delahaye)The various possible phases of the Test Facility (moderator: I. Wilson)Constraints from the LPI: schedule-building-components (moderator: J.P. Potier)The injector system based on thermoionic gun (moderator: L. Rinolfi)Possible option of photo-injector (moderators: G. Suberlucq - S. Hutchins)Trade off between energy and current in CTF3 (moderator: R. Corsini)The RF power source of the drive beam accelerator (moderator: P. Pearce)RF pulse compression for the drive beam accelerator (moderator: Y. Syratchev)The drive beam accelerator (moderator: L. Thorndahl)Beam dynamics in drive beam accelerator (moderators: G. Guignard - D. Schulte)The combiner ring and delay loop (moderator: R. Corsini)The 30 GHz modules of the drive beam decelerator and main beam accelerator (moderator: W. Wuensch)Possible tests in CTF2 in preparation for CTF3 (moderator: H. Braun) Conclusion programme of work (moderator: J.P. Delahaye)

  2. CTF: Computer security competitions for learning and fun

    CERN Document Server

    CERN. Geneva

    2015-01-01

    CTF hacking competitions condense practical security knowledge in short and measurable challenges, in short: education, fun, prizes and fame! This talk is an introduction to these type of competitions from a player perspective over the years.

  3. OTR studies for the high charge CTF3 beam

    CERN Document Server

    Bravin, Enrico; Vermare, C

    2003-01-01

    The CTF3 (CLIC Test Facility 3) will produce 1.56µs long intense electron pulses. The unbunched 5.4A beam of the injector will have a transverse beam size ~1mm. After the buncher the current is reduced to 3.5A and the transverse size varies between a few hundred micrometers and one millimetre along the length of the linac. Calculations indicate that these beam parameters will impose an unbearable thermal load for the intercepting screens currently in use (scintillators and aluminium OTR foils). Graphite and SiC have been investigated as possible alternative materials for the OTR radiators. The possibility of replacing scintillating screens with OTR targets at the low energies of the injector has also been considered. A possible limitation in the use of such high temperature radiators has been identified; ions released from the heated target could focus further the beam with the risk of damaging the target itself and/or blowing up the beam. This would also affect the emittance measurement and would hinder any...

  4. Cost modelling as decision support when locating manufacturing facilities

    Directory of Open Access Journals (Sweden)

    Christina Windmark

    2016-01-01

    Full Text Available This paper presents a methodology for cost estimation in developing decision supports for production location issues. The purpose is to provide a structured work procedure to be used by practitioners to derive the knowledge needed to make informed decisions on where to locate production. This paper present a special focus on how to integrate cost effects during the decision process. The work procedure and cost models were developed in close collaboration with a group of industrial partners. The result is a structure of cost estimation tools aligned to different steps in the work procedure. The cost models can facilitate both cost estimation for manufacturing a product under new preconditions, including support costs, and cost simulations to analyse the risks of wrong estimations and uncertainties in the input parameters. Future research aims to test the methodology in ongoing transfer projects to further understand difficulties in managing global production systems. In existing models and methods presented in the literature, cost is usually estimated on a too aggregated level to be suitable for decision support regarding production system design. The cost estimation methodology presented here provides new insights on cost driving factors related to the production system.

  5. 34 CFR 395.30 - The location and operation of vending facilities for blind vendors on Federal property.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false The location and operation of vending facilities for... § 395.30 The location and operation of vending facilities for blind vendors on Federal property. (a... facilities on any Federal property. (b) Any limitation on the location or operation of a vending facility for...

  6. Comparison of optimized algorithms in facility location allocation problems with different distance measures

    Science.gov (United States)

    Kumar, Rakesh; Chandrawat, Rajesh Kumar; Garg, B. P.; Joshi, Varun

    2017-07-01

    Opening the new firm or branch with desired execution is very relevant to facility location problem. Along the lines to locate the new ambulances and firehouses, the government desires to minimize average response time for emergencies from all residents of cities. So finding the best location is biggest challenge in day to day life. These type of problems were named as facility location problems. A lot of algorithms have been developed to handle these problems. In this paper, we review five algorithms that were applied to facility location problems. The significance of clustering in facility location problems is also presented. First we compare Fuzzy c-means clustering (FCM) algorithm with alternating heuristic (AH) algorithm, then with Particle Swarm Optimization (PSO) algorithms using different type of distance function. The data was clustered with the help of FCM and then we apply median model and min-max problem model on that data. After finding optimized locations using these algorithms we find the distance from optimized location point to the demanded point with different distance techniques and compare the results. At last, we design a general example to validate the feasibility of the five algorithms for facilities location optimization, and authenticate the advantages and drawbacks of them.

  7. [The acquisition of schemata about location of urban facilities in public space].

    Science.gov (United States)

    Kawai, Miho; Murakoshi, Shin

    2003-12-01

    The purpose of this study is to investigate acquisition of schemata about location of urban facilities. Materials were photos of public space, in which one of three urban facilities (a mailbox, a public-telephone, and a coin--operated locker) were removed by photo-retouching software. The task was to choose the most suitable urban facility for each corrected-photo and to locate it at the most suitable position on the photo. Among three participant groups (primary school 3rd grade: n = 153, primary school 5th grade: n = 118, undergraduate: n = 250), undergraduates chose the most suitable urban facility, and their located position was more concentrated. The results suggest that participants acquire the schemata and use them for inference. Although even 3rd grade children have acquired the schema to some extent, the adults have more detailed schemata of urban facilities in public space.

  8. Making regional facility location decisions: the example of Hospital do Oeste Norte, Portugal

    National Research Council Canada - National Science Library

    Gonçalves, Jorge; Antunes Ferreira, J; Condessa, Beatriz

    2014-01-01

    This paper seeks to contribute to the debate on the decision-making process for the location of large public facilities, responding to the growing demand for greater rationality in public investment...

  9. Validation of CTF Droplet Entrainment and Annular/Mist Closure Models using Riso Steam/Water Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Wysocki, Aaron J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    This report summarizes the work done to validate the droplet entrainment and de-entrainment models as well as two-phase closure models in the CTF code by comparison with experimental data obtained at Riso National Laboratory. The Riso data included a series of over 250 steam/water experiments that were performed in both tube and annulus geometries over a range of various pressures and outlet qualities. Experimental conditions were set so that the majority of cases were in the annular/mist ow regime. Measurements included liquid lm ow rate, droplet ow rate, lm thickness, and two-phase pressure drop. CTF was used to model 180 of the tubular geometry cases, matching experimental geometry, outlet pressure, and outlet ow quality to experimental values. CTF results were compared to the experimental data at the outlet of the test section in terms of vapor and entrained liquid ow fractions, pressure drop per unit length, and liquid lm thickness. The entire process of generating CTF input decks, running cases, extracting data, and generating comparison plots was scripted using Python and Matplotlib for a completely automated validation process. All test cases and scripting tools have been committed to the COBRA-TF master repository and selected cases have been added to the continuous testing system to serve as regression tests. The dierences between the CTF- and experimentally-calculated ow fraction values were con- sistent with previous calculations by Wurtz, who applied the same entrainment correlation to the same data. It has been found that CTF's entrainment/de-entrainment predictive capability in the annular/mist ow regime for this particular facility is comparable to the licensed industry code, COBRAG. While lm and droplet predictions are generally good, it has been found that accuracy is diminished at lower ow qualities. This nding is consistent with the noted deciencies in the Wurtz entrainment model employed by CTF. The CTF predicted two-phase pressure drop in

  10. Library Facility Siting and Location Handbook. The Greenwood Library Management Collection.

    Science.gov (United States)

    Koontz, Christine M.

    This handbook is a guide to the complex process of library facility siting and location. It includes relevant research and professionals' siting experiences, as well as actual case studies of closures, openings, mergers, and relocations of library facilities. While the bulk of the volume provides practical information, the work also presents an…

  11. An iterated tabu search heuristic for the Single Source Capacitated Facility Location Problem

    DEFF Research Database (Denmark)

    Ho, Sin C.

    2015-01-01

    This paper discusses the Single Source Capacitated Facility Location Problem (SSCFLP) where the problem consists in determining a subset of capacitated facilities to be opened in order to satisfy the customers’ demands such that total costs are minimized. The paper presents an iterated tabu search...

  12. 77 FR 58470 - Irradiation Treatment; Location of Facilities in the Southern United States; Technical Amendment

    Science.gov (United States)

    2012-09-21

    ... Animal and Plant Health Inspection Service 7 CFR Part 319 RIN 0579-AD35 Irradiation Treatment; Location of Facilities in the Southern United States; Technical Amendment AGENCY: Animal and Plant Health... approving treatment facilities for fruits, vegetables, and other articles to prevent the introduction or...

  13. An approximation algorithm for a facility location problem with inventories and stochastic demands

    NARCIS (Netherlands)

    Bumb, A.F.; van Ommeren, Jan C.W.; Megiddo, N.; Xu, Y.; Zhu, B.

    2005-01-01

    In this article we propose, for any $\\varepsilon$ > 0, a 2(1 + $\\varepsilon$)-approximation algorithm for a facility location problem with stochastic demands. At open facilities, inventory is kept such that arriving requests find a zero inventory with (at most) some pre-specified probability. The

  14. A MULTI-PRODUCT AND MULTI-PERIOD FACILITY LOCATION MODEL FOR REVERSE LOGISTICS

    OpenAIRE

    Benaissa Mounir; Benabdelhafid Abdellatif

    2010-01-01

    Reverse logistics has become an important entity in the world economy. Businesses increasingly have to cope with product returns, mandated environmental regulations and increasing costs associated with product disposal. This study presents a cost-minimization model for a multi-time-step, multi-type product waste reverse logistics system. The facility location is a central issue of the logistics networks. In this article we are interested in optimizing of the sites facility location for a reve...

  15. An Integrated Intuitionistic Fuzzy Multi Criteria Decision Making Method for Facility Location Selection

    OpenAIRE

    BORAN, Fatih

    2011-01-01

    The facility location selection, which is one of the important activities in strategic planning for a wide range of private and public companies, is a multi-criteria decision making problem including both quantitative and qualitative criteria. Traditional methods for facility location selection can not be effectively handled because information can not be represented by precise information under many conditions. This paper proposes the integration of intuitionistic fuzzy preference relation a...

  16. A reliable facility location design model with site-dependent disruption in the imperfect information context.

    Science.gov (United States)

    Yun, Lifen; Wang, Xifu; Fan, Hongqiang; Li, Xiaopeng

    2017-01-01

    This paper proposes a reliable facility location design model under imperfect information with site-dependent disruptions; i.e., each facility is subject to a unique disruption probability that varies across the space. In the imperfect information contexts, customers adopt a realistic "trial-and-error" strategy to visit facilities; i.e., they visit a number of pre-assigned facilities sequentially until they arrive at the first operational facility or give up looking for the service. This proposed model aims to balance initial facility investment and expected long-term operational cost by finding the optimal facility locations. A nonlinear integer programming model is proposed to describe this problem. We apply a linearization technique to reduce the difficulty of solving the proposed model. A number of problem instances are studied to illustrate the performance of the proposed model. The results indicate that our proposed model can reveal a number of interesting insights into the facility location design with site-dependent disruptions, including the benefit of backup facilities and system robustness against variation of the loss-of-service penalty.

  17. Mathematical Model and Stochastic Multi-Criteria Acceptability Analysis for Facility Location Problem

    Directory of Open Access Journals (Sweden)

    Selahattin Karabay

    2016-06-01

    Full Text Available This paper studies a real-life public sector facility location problem. The problem fundamentally originated from the idea of downsizing the number of service centres. However, opening of new facilities is also considered in case the current facilities fail to fulfil general management demands. Two operation research methodologies are used to solve the problem and the obtained results are compared. First, a mathematical programming model is introduced to determine where the new facilities will be located, and which districts get service from which facilities, as if there were currently no existing facilities. Second, the Stochastic Multi-criteria Acceptability Analysis-TRI (SMAA-TRI method is used to select the best suitable places for service centres among the existing facilities. It is noted that the application of mathematical programming model and SMAA-TRI integration approach on facility location problem is the first study in literature. Compression of outcomes shows that mixed integer linear programming (MILP model tries to open facilities in districts which are favoured by SMAA-TRI solution.

  18. Chemical Transfer (Single Small-Scale) Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Description/History: Chemistry laboratoryThe Chemical Transfer Facility (CTF)  is the only U.S. single small-scale  facility, a single repository for the Army’s...

  19. Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.

    Science.gov (United States)

    Mayer, M L; Gygi, S P; Aebersold, R; Hieter, P

    2001-05-01

    We have identified and characterized an alternative RFC complex RFC(Ctf18p, Ctf8p, Dcc1p) that is required for sister chromatid cohesion and faithful chromosome transmission. Ctf18p, Ctf8p, and Dcc1p interact physically in a complex with Rfc2p, Rfc3p, Rfc4p, and Rfc5p but not with Rfc1p or Rad24p. Deletion of CTF18, CTF8, or DCC1 singly or in combination (ctf18Deltactf8Deltadcc1Delta) leads to sensitivity to microtubule depolymerizing drugs and a severe sister chromatid cohesion defect. Furthermore, temperature-sensitive mutations in RFC4 result in precocious sister chromatid separation. Our results highlight a novel function of the RFC proteins and support a model in which sister chromatid cohesion is established at the replication fork via a polymerase switching mechanism and a replication-coupled remodeling of chromatin.

  20. New spatial clustering-based models for optimal urban facility location considering geographical obstacles

    Science.gov (United States)

    Javadi, Maryam; Shahrabi, Jamal

    2014-03-01

    The problems of facility location and the allocation of demand points to facilities are crucial research issues in spatial data analysis and urban planning. It is very important for an organization or governments to best locate its resources and facilities and efficiently manage resources to ensure that all demand points are covered and all the needs are met. Most of the recent studies, which focused on solving facility location problems by performing spatial clustering, have used the Euclidean distance between two points as the dissimilarity function. Natural obstacles, such as mountains and rivers, can have drastic impacts on the distance that needs to be traveled between two geographical locations. While calculating the distance between various supply chain entities (including facilities and demand points), it is necessary to take such obstacles into account to obtain better and more realistic results regarding location-allocation. In this article, new models were presented for location of urban facilities while considering geographical obstacles at the same time. In these models, three new distance functions were proposed. The first function was based on the analysis of shortest path in linear network, which was called SPD function. The other two functions, namely PD and P2D, were based on the algorithms that deal with robot geometry and route-based robot navigation in the presence of obstacles. The models were implemented in ArcGIS Desktop 9.2 software using the visual basic programming language. These models were evaluated using synthetic and real data sets. The overall performance was evaluated based on the sum of distance from demand points to their corresponding facilities. Because of the distance between the demand points and facilities becoming more realistic in the proposed functions, results indicated desired quality of the proposed models in terms of quality of allocating points to centers and logistic cost. Obtained results show promising

  1. Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8.

    Science.gov (United States)

    Murakami, Takeshi; Takano, Ryuji; Takeo, Satoshi; Taniguchi, Rina; Ogawa, Kaori; Ohashi, Eiji; Tsurimoto, Toshiki

    2010-11-05

    One of the proliferating cell nuclear antigen loader complexes, Ctf18-replication factor C (RFC), is involved in sister chromatid cohesion. To examine its relationship with factors involved in DNA replication, we performed a proteomics analysis of Ctf18-interacting proteins. We found that Ctf18 interacts with a replicative DNA polymerase, DNA polymerase ε (pol ε). Co-immunoprecipitation with recombinant Ctf18-RFC and pol ε demonstrated that their binding is direct and mediated by two distinct interactions, one weak and one stable. Three subunits that are specifically required for cohesion in yeast, Ctf18, Dcc1, and Ctf8, formed a trimeric complex (18-1-8) and together enabled stable binding with pol ε. The C-terminal 23-amino acid stretch of Ctf18 was necessary for the trimeric association of 18-1-8 and was required for the stable interaction. The weak interaction was observed with alternative loader complexes including Ctf18-RFC(5), which lacks Dcc1 and Ctf8, suggesting that the common loader structures, including the RFC small subunits (RFC2-5), are responsible for the weak interaction. The two interaction modes, mediated through distinguishable structures of Ctf18-RFC, both occurred through the N-terminal half of pol ε, which includes the catalytic domain. The addition of Ctf18-RFC or Ctf18-RFC(5) to the DNA synthesis reaction caused partial inhibition and stimulation, respectively. Thus, Ctf18-RFC has multiple interactions with pol ε that promote polymorphic modulation of DNA synthesis. We propose that their interaction alters the DNA synthesis mode to enable the replication fork to cooperate with the establishment of cohesion.

  2. The adequacy of the facility and the location of waste collection

    Science.gov (United States)

    Ulrich-Supovec, Marjana

    2017-06-01

    The purpose of this article is to summarise some provisions of the legislation applicable in the territory of the Republic of Slovenia that have to be complied with when selecting facilities intended for waste collection. In addition to equipment, the adequacy of such facility also depends on its site. Not only waste management legislation and environment protection legislation, but also legislation governing water, nature preservation and conservation, natural and cultural heritage and mining legislation stipulate the possibility of using facilities where collectors can sort and store waste before depositing it for subsequent management. This paper presents location examples where various factors exclude the possibility of using facilities as waste collection centres.

  3. Planning of public healthcare facility using a location allocation modelling: A case study

    Science.gov (United States)

    Shariff, S. Sarifah Radiah; Moin, Noor Hasnah; Omar, Mohd

    2014-09-01

    Finding the correct location of any facility and determining the demands which are to be assigned to it is very crucial in public health service. This is to ensure that the public gain maximum benefits. This article analyzes the previous location decisions of public primary healthcare (PHC) facilities in the district of Kuala Langat, Malaysia. With total population of 220214 (in 2010), the PHC in the district is currently served by 28 facilities. The percentages of total population covered (in 2007) within the maximum allowable distance of 3km and 5km are 69.7 percent and 77.8 percent respectively. This is very low compared to the Malaysian National Health Policy of Health for All or 100 percent coverage. The determination of health facility location should be planned carefully to further increase effective primary health service to the nation that is required for economic sustainability.

  4. A hybrid algorithm for stochastic single-source capacitated facility location problem with service level requirements

    Directory of Open Access Journals (Sweden)

    Hosseinali Salemi

    2016-04-01

    Full Text Available Facility location models are observed in many diverse areas such as communication networks, transportation, and distribution systems planning. They play significant role in supply chain and operations management and are one of the main well-known topics in strategic agenda of contemporary manufacturing and service companies accompanied by long-lasting effects. We define a new approach for solving stochastic single source capacitated facility location problem (SSSCFLP. Customers with stochastic demand are assigned to set of capacitated facilities that are selected to serve them. It is demonstrated that problem can be transformed to deterministic Single Source Capacitated Facility Location Problem (SSCFLP for Poisson demand distribution. A hybrid algorithm which combines Lagrangian heuristic with adjusted mixture of Ant colony and Genetic optimization is proposed to find lower and upper bounds for this problem. Computational results of various instances with distinct properties indicate that proposed solving approach is efficient.

  5. Three formulations of the multi-type capacitated facility location problem

    DEFF Research Database (Denmark)

    Klose, Andreas

    The "multi-type" or "modular" capacitated facility location problem is a discrete location model that addresses non-convex piecewise linear production costs as, for instance, staircase cost functions. The literature basically distinguishes three different ways to formulate non-convex piecewise...

  6. Facility Location with Client Latencies: Linear-Programming based Techniques for Minimum-Latency Problems

    CERN Document Server

    Chakrabarty, Deeparnab

    2010-01-01

    We introduce a problem that is a common generalization of the uncapacitated facility location and minimum latency (ML) problems, where facilities need to be opened to serve clients and also need to be sequentially activated before they can provide service. Formally, we are given a set \\F of n facilities with facility-opening costs {f_i}, a set of m clients, and connection costs {c_{ij}} specifying the cost of assigning a client j to a facility i, a root node r denoting the depot, and a time metric d on \\F\\cup{r}. Our goal is to open a subset F of facilities, find a path P starting at r and spanning F to activate the open facilities, and connect each client j to a facility \\phi(j)\\in F, so as to minimize \\sum_{i\\in F}f_i +\\sum_{clients j}(c_{\\phi(j),j}+t_j), where t_j is the time taken to reach \\phi(j) along path P. We call this the minimum latency uncapacitated facility location (MLUFL) problem. Our main result is an O(\\log n\\max{\\log n,\\log m})-approximation for MLUFL. We also show that any improvement in th...

  7. Development and evaluation of an integrated emergency response facility location model

    Directory of Open Access Journals (Sweden)

    Jae-Dong Hong

    2012-06-01

    Full Text Available Purpose: The purpose of this paper is to propose and compare the performance of the “two” robust mathematical models, the Robust Integer Facility Location (RIFL and the Robust Continuous Facility Location (RCFL models, to solve the emergency response facility and transportation problems in terms of the total logistics cost and robustness. Design/methodology/approach: The emergency response facilities include distribution warehouses (DWH where relief goods are stored, commodity distribution points (CDP, and neighborhood locations. Authors propose two robust models: the Robust Integer Facility Location (RIFL model where the demand of a CDP is covered by a main DWH or a backup CDP; the Robust Continuous Facility Location (RCFL model where that of a CDP is covered by multiple DWHs. The performance of these models is compared with each other and to the Regular Facility Location (RFL model where a CDP is covered by one main DWH. The case studies with multiple scenarios are analyzed. Findings: The results illustrate that the RFL outperforms others under normal conditions while the RCFL outperforms others under the emergency conditions. Overall, the total logistics cost and robustness level of the RCFL outperforms those of other models while the performance of RFL and RIFL is mixed between the cost and robustness index. Originality/value: Two new emergency distribution approaches are modeled, and evaluated using case studies. In addition to the total logistics cost, the robustness index is uniquely presented and applied. The proposed models and robustness concept are hoped to shed light to the future works in the field of disaster logistics management.

  8. Scaling and entropy in p-median facility location along a line

    Science.gov (United States)

    Gastner, Michael T.

    2011-09-01

    The p-median problem is a common model for optimal facility location. The task is to place p facilities (e.g., warehouses or schools) in a heterogeneously populated space such that the average distance from a person's home to the nearest facility is minimized. Here we study the special case where the population lives along a line (e.g., a road or a river). If facilities are optimally placed, the length of the line segment served by a facility is inversely proportional to the square root of the population density. This scaling law is derived analytically and confirmed for concrete numerical examples of three US interstate highways and the Mississippi River. If facility locations are permitted to deviate from the optimum, the number of possible solutions increases dramatically. Using Monte Carlo simulations, we compute how scaling is affected by an increase in the average distance to the nearest facility. We find that the scaling exponents change and are most sensitive near the optimum facility distribution.

  9. A greedy heuristic algorithm for solving the capacitated planar multi-facility location-allocation problem

    Science.gov (United States)

    Luis, Martino; Ramli, Mohammad Fadzli; Lin, Abdullah

    2016-10-01

    This study investigates the capacitated planar multi-facility location-allocation problem by considering various capacity constraints. The problem is also known as the capacitated multi-source Weber problem, where the number of facilities to be located is specified and each of which has a capacity constraint. An efficient greedy randomised adaptive search procedure (GRASP) is proposed to deal with the problem. A scheme that applies the furthest distance rule (FDR) and self-adjusted threshold parameters to generate initial facility locations that are situated sparsely within GRASP framework is also presented. The construction of the restricted candidate list (RCL) within GRASP is also guided by applying a concept of restricted regions that prevents new facility locations to be sited too close to the previous selected facility locations. The performance of the proposed GRASP heuristics is tested using benchmark data sets from literature. The computational experiments show that the proposed methods provide encouraging solutions when compared to recently published papers. Some future research avenues on the subject are also briefly highlighted.

  10. A minisum model with forbidden regions for locating a semi-desirable facility in the plane

    DEFF Research Database (Denmark)

    Juel, Henrik; Brimberg, Jack

    1998-01-01

    Most facilities in today's technological society may be classified as semi-desirable. That is, the facility provides a benefit or service to society, while adversely affecting the quality of life or social values in a number of possible ways. The paper proposes a location model for a new semi......-desirable facility that accounts for the service costs by a standard minisum objective with arbitrary travel distance function. The social costs are imputed by specifying around each demand point or population center a convex forbidden region, also defined by an arbitrary distance metric, in which the new facility...... may not be located. A general solution algorithm is suggested, and the methodology is applied to circular forbidden regions and special travel distance functions....

  11. A minisum model with forbidden regions for locating a semi-desirable facility in the plane

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik

    Most facilities in today's technological society may be classified as semi-desirable. That is, the facility provides a benefit or service to society, while adversely affecting the quality of life or social values in a number of possible ways. The paper proposes a location model for a new semi......-desirable facility which accounts for the service costs by a standard minisum objective with arbitrary travel distance function. The social costs are imputed by specifying around each demand point or population center a convex forbidden region, also defined by an arbitrary distance metric, in which the new facility...... may not be located. A general solution algorithm is suggested, and the methodology applied to circular forbidden regions and special travel distance functions....

  12. An analytic network process approach for locating undesirable facilities: an example from Istanbul, Turkey.

    Science.gov (United States)

    Tuzkaya, Gülfem; Onüt, Semih; Tuzkaya, Umut R; Gülsün, Bahadir

    2008-09-01

    Locating an undesirable facility is a sophisticated problem, for the evaluation procedures involve several objectives and the solution to the problem calls for some compromises to be made between probable conflicting criteria. This paper addresses the problem of undesirable facility location selection using the analytic network process (ANP), a multi-criteria decision-making technique. The ANP technique enables us to consider both qualitative and quantitative criteria as well as the interdependencies and feedbacks. A number of criteria (benefits, opportunities, costs and risks) and their sub-criteria are considered for siting a new facility with which this study has dealt. The questions of what criteria would be considered and what the interdependencies between these criteria and their weights would be were discussed and determined via interviews with some competent authorities of the Istanbul Municipality and of two environmental organizations. Four representative locations were evaluated and the most convenient one was selected. This was followed by the sensitivity analyses of the results.

  13. Inferring Groups of Objects, Preferred Routes, and Facility Locations from Trajectories

    DEFF Research Database (Denmark)

    Ceikute, Vaida

    In today’s society, GPS-enabled devices are used widely. A broad range of location-based services (LBS) allow users to receive and share information related to their positions. Thus, it is possible to accumulate GPS data, and it is expected that the amount of available GPS data will increase very...... on empirical studies with real route usage data and an existing online routing service. Finally, we use GPS trajectories as customer flows in a modern formulation of the facility location problem. We propose a practical framework that, given a road network, a set of trajectories, and a set of existing...... facilities, computes the optimal segment(s) for the location of a new facility. Customer flows are scored, and the score of a flow is distributed among the road segments that the flow covers according to a score distribution model. We propose two algorithms that adopt different approaches to compute...

  14. Solving the multiple competitive facilities location and design problem on the plane.

    Science.gov (United States)

    Redondo, Juana López; Fernández, José; García, Inmaculada; Ortigosa, Pilar M

    2009-01-01

    A continuous location problem in which a firm wants to set up two or more new facilities in a competitive environment is considered. Other facilities offering the same product or service already exist in the area. Both the locations and the qualities of the new facilities are to be found so as to maximize the profit obtained by the firm. This is a global optimization problem, with many local optima. In this paper we analyze several approaches to solve it, namely, three multistart local search heuristics, a multistart simulated annealing algorithm, and two variants of an evolutionary algorithm. Through a comprehensive computational study it is shown that the evolutionary algorithms are the heuristics that provide the best solutions. Furthermore, using a set of problems for which the optimal solutions are known, only the evolutionary algorithms were able to find the optimal solutions for all the instances. The evolutionary strategies presented in this paper can be easily adapted to handle other continuous location problems.

  15. MIP models for connected facility location: A theoretical and computational study☆

    Science.gov (United States)

    Gollowitzer, Stefan; Ljubić, Ivana

    2011-01-01

    This article comprises the first theoretical and computational study on mixed integer programming (MIP) models for the connected facility location problem (ConFL). ConFL combines facility location and Steiner trees: given a set of customers, a set of potential facility locations and some inter-connection nodes, ConFL searches for the minimum-cost way of assigning each customer to exactly one open facility, and connecting the open facilities via a Steiner tree. The costs needed for building the Steiner tree, facility opening costs and the assignment costs need to be minimized. We model ConFL using seven compact and three mixed integer programming formulations of exponential size. We also show how to transform ConFL into the Steiner arborescence problem. A full hierarchy between the models is provided. For two exponential size models we develop a branch-and-cut algorithm. An extensive computational study is based on two benchmark sets of randomly generated instances with up to 1300 nodes and 115,000 edges. We empirically compare the presented models with respect to the quality of obtained bounds and the corresponding running time. We report optimal values for all but 16 instances for which the obtained gaps are below 0.6%. PMID:25009366

  16. MIP models for connected facility location: A theoretical and computational study.

    Science.gov (United States)

    Gollowitzer, Stefan; Ljubić, Ivana

    2011-02-01

    This article comprises the first theoretical and computational study on mixed integer programming (MIP) models for the connected facility location problem (ConFL). ConFL combines facility location and Steiner trees: given a set of customers, a set of potential facility locations and some inter-connection nodes, ConFL searches for the minimum-cost way of assigning each customer to exactly one open facility, and connecting the open facilities via a Steiner tree. The costs needed for building the Steiner tree, facility opening costs and the assignment costs need to be minimized. We model ConFL using seven compact and three mixed integer programming formulations of exponential size. We also show how to transform ConFL into the Steiner arborescence problem. A full hierarchy between the models is provided. For two exponential size models we develop a branch-and-cut algorithm. An extensive computational study is based on two benchmark sets of randomly generated instances with up to 1300 nodes and 115,000 edges. We empirically compare the presented models with respect to the quality of obtained bounds and the corresponding running time. We report optimal values for all but 16 instances for which the obtained gaps are below 0.6%.

  17. A Game Theoretical Model for Location of Terror Response Facilities under Capacitated Resources

    Science.gov (United States)

    Kang, Qi; Xu, Weisheng; Wu, Qidi

    2013-01-01

    This paper is concerned with the effect of capacity constraints on the locations of terror response facilities. We assume that the state has limited resources, and multiple facilities may be involved in the response until the demand is satisfied consequently. We formulate a leader-follower game model between the state and the terrorist and prove the existence and uniqueness of the Nash equilibrium. An integer linear programming is proposed to obtain the equilibrium results when the facility number is fixed. The problem is demonstrated by a case study of the 19 districts of Shanghai, China. PMID:24459446

  18. A game theoretical model for location of terror response facilities under capacitated resources.

    Science.gov (United States)

    Meng, Lingpeng; Kang, Qi; Han, Chuanfeng; Xu, Weisheng; Wu, Qidi

    2013-01-01

    This paper is concerned with the effect of capacity constraints on the locations of terror response facilities. We assume that the state has limited resources, and multiple facilities may be involved in the response until the demand is satisfied consequently. We formulate a leader-follower game model between the state and the terrorist and prove the existence and uniqueness of the Nash equilibrium. An integer linear programming is proposed to obtain the equilibrium results when the facility number is fixed. The problem is demonstrated by a case study of the 19 districts of Shanghai, China.

  19. A Game Theoretical Model for Location of Terror Response Facilities under Capacitated Resources

    Directory of Open Access Journals (Sweden)

    Lingpeng Meng

    2013-01-01

    Full Text Available This paper is concerned with the effect of capacity constraints on the locations of terror response facilities. We assume that the state has limited resources, and multiple facilities may be involved in the response until the demand is satisfied consequently. We formulate a leader-follower game model between the state and the terrorist and prove the existence and uniqueness of the Nash equilibrium. An integer linear programming is proposed to obtain the equilibrium results when the facility number is fixed. The problem is demonstrated by a case study of the 19 districts of Shanghai, China.

  20. A simulated annealing methodology to multiproduct capacitated facility location with stochastic demand.

    Science.gov (United States)

    Qin, Jin; Xiang, Hui; Ye, Yong; Ni, Linglin

    2015-01-01

    A stochastic multiproduct capacitated facility location problem involving a single supplier and multiple customers is investigated. Due to the stochastic demands, a reasonable amount of safety stock must be kept in the facilities to achieve suitable service levels, which results in increased inventory cost. Based on the assumption of normal distributed for all the stochastic demands, a nonlinear mixed-integer programming model is proposed, whose objective is to minimize the total cost, including transportation cost, inventory cost, operation cost, and setup cost. A combined simulated annealing (CSA) algorithm is presented to solve the model, in which the outer layer subalgorithm optimizes the facility location decision and the inner layer subalgorithm optimizes the demand allocation based on the determined facility location decision. The results obtained with this approach shown that the CSA is a robust and practical approach for solving a multiple product problem, which generates the suboptimal facility location decision and inventory policies. Meanwhile, we also found that the transportation cost and the demand deviation have the strongest influence on the optimal decision compared to the others.

  1. Verified centers, nonverified centers, or other facilities: a national analysis of burn patient treatment location.

    Science.gov (United States)

    Zonies, David; Mack, Christopher; Kramer, Bradley; Rivara, Frederick; Klein, Matthew

    2010-03-01

    Although comprehensive burn care requires significant resources, patients may be treated at verified burn centers, nonverified burn centers, or other facilities due to a variety of factors. The purpose of this study was to evaluate the association between patient and injury characteristics and treatment location using a national database. We performed an analysis of all burn patients admitted to United States hospitals participating in the Healthcare Cost and Utilization Project over 2 years. Univariate and multivariate analyses were performed to identify patient and injury factors associated with the likelihood of treatment at designated burn care facilities. Definitive care facilities were categorized as American Burn Association-verified centers, nonverified burn centers, or other facilities. During the 2 years of the study, 29,971 burn patients were treated in 1,376 hospitals located in 19 participating states. A total of 6,712 (22%) patients were treated at verified centers, with 26% and 52% treated at nonverified or other facilities, respectively. Patients treated at verified centers were younger than those treated at nonverified or other facilities (33.1 years versus 33.7 years versus 41.9 years; p facilities. Published by Elsevier Inc.

  2. Making regional facility location decisions: the example of Hospital do Oeste Norte, Portugal

    Directory of Open Access Journals (Sweden)

    Jorge Gonçalves

    2014-11-01

    Full Text Available This paper seeks to contribute to the debate on the decision-making process for the location of large public facilities, responding to the growing demand for greater rationality in public investment whilst still offering services of quality and addressing the problem of spatial friction. The specific problem analysed in this paper is the need to define the best location for a public hospital in a particular region of Portugal. The singularity of the approach adopted lies above all in the seg- mentation into macro-location and micro-location.

  3. Making regional facility location decisions: the example of Hospital do Oeste Norte, Portugal.

    Science.gov (United States)

    Gonçalves, Jorge; Antunes Ferreira, J; Condessa, Beatriz

    2014-11-01

    This paper seeks to contribute to the debate on the decision-making process for the location of large public facilities, responding to the growing demand for greater rationality in public investment whilst still offering services of quality and addressing the problem of spatial friction. The specific problem analysed in this paper is the need to define the best location for a public hospital in a particular region of Portugal. The singularity of the approach adopted lies above all in the segmentation into macro-location and micro-location.

  4. An Approximation Algorithm for the Facility Location Problem with Lexicographic Minimax Objective

    Directory of Open Access Journals (Sweden)

    Ľuboš Buzna

    2014-01-01

    Full Text Available We present a new approximation algorithm to the discrete facility location problem providing solutions that are close to the lexicographic minimax optimum. The lexicographic minimax optimum is a concept that allows to find equitable location of facilities serving a large number of customers. The algorithm is independent of general purpose solvers and instead uses algorithms originally designed to solve the p-median problem. By numerical experiments, we demonstrate that our algorithm allows increasing the size of solvable problems and provides high-quality solutions. The algorithm found an optimal solution for all tested instances where we could compare the results with the exact algorithm.

  5. Facility Location Modeling in Multi-Echelon Distribution System: A Case Study of Indonesian Liquefied Petroleum Gas Supply Chain

    Directory of Open Access Journals (Sweden)

    Ilyas Masudin

    2013-04-01

    Full Text Available This paper presents model of Indonesian LPG supply chain by opening new facilities (new echelon taking into account the current facilities. The objective is to investigate the relation between distribution costs such as transportation, inventory cost and facility location in Indonesian multi-echelon LPG supply chain. Fixed-charged capacitated facility location problem is used to determine the optimal solution of the proposed model. In the sensitivity analysis, it is reported that the trade-offs between facility locations and distribution costs are exist. Results report that as the number of facility increases, total transportation and inventory cost also increase.

  6. Locations and attributes of utility-scale solar power facilities in Colorado and New Mexico, 2011

    Science.gov (United States)

    Ignizio, Drew A.; Carr, Natasha B.

    2012-01-01

    The data series consists of polygonal boundaries for utility-scale solar power facilities (both photovoltaic and concentrating solar power) located within Colorado and New Mexico as of December 2011. Attributes captured for each facility include the following: facility name, size/production capacity (in MW), type of solar technology employed, location, state, operational status, year the facility came online, and source identification information. Facility locations and perimeters were derived from 1-meter true-color aerial photographs (2011) produced by the National Agriculture Imagery Program (NAIP); the photographs have a positional accuracy of about ±5 meters (accessed from the NAIP GIS service: http://gis.apfo.usda.gov/arcgis/services). Solar facility perimeters represent the full extent of each solar facility site, unless otherwise noted. When visible, linear features such as fences or road lines were used to delineate the full extent of the solar facility. All related equipment including buildings, power substations, and other associated infrastructure were included within the solar facility. If solar infrastructure was indistinguishable from adjacent infrastructure, or if solar panels were installed on existing building tops, only the solar collecting equipment was digitized. The "Polygon" field indicates whether the "equipment footprint" or the full "site outline" was digitized. The spatial accuracy of features that represent site perimeters or an equipment footprint is estimated at +/- 10 meters. Facilities under construction or not fully visible in the NAIP imagery at the time of digitization (December 2011) are represented by an approximate site outline based on the best available information and documenting materials. The spatial accuracy of these facilities cannot be estimated without more up-to-date imagery – users are advised to consult more recent imagery as it becomes available. The "Status" field provides information about the operational

  7. Three formulations of the multi-type capacitated facility location problem

    DEFF Research Database (Denmark)

    Klose, Andreas

    The "multi-type" or "modular" capacitated facility location problem is a discrete location model that addresses non-convex piecewise linear production costs as, for instance, staircase cost functions. The literature basically distinguishes three different ways to formulate non-convex piecewise li....... We show that the latter formulation, with these inequalities included, strictly dominates the other two ways of formulating the problem. We additionally investigate different strategies of including these variable upper bounds within the model using a common MIP solver....

  8. 18 CFR 292.208 - Special requirements for hydroelectric small power production facilities located at a new dam or...

    Science.gov (United States)

    2010-04-01

    ... for hydroelectric small power production facilities located at a new dam or diversion. 292.208 Section... requirements for hydroelectric small power production facilities located at a new dam or diversion. (a) A... means of a new dam or diversion (as that term is defined in § 292.202(p)) is a qualifying facility...

  9. A bicriteria model for locating a semi-desirable facility in

    DEFF Research Database (Denmark)

    Juel, Henrik; Brimberg, Jack

    1998-01-01

    We consider the problem of locating a facility in the plane. Customers want the facility to be close to obtain cheaply the service offered by it. But customers also want the facility to be far away to avoid the pollution from it. We model the situation using two criteria: One is the well-known mi......We consider the problem of locating a facility in the plane. Customers want the facility to be close to obtain cheaply the service offered by it. But customers also want the facility to be far away to avoid the pollution from it. We model the situation using two criteria: One is the well......-known minisum criterion; in the other we want to minimize the weighted sum of Euclidean distances raised to a negative power. The second criterion is analyzed in some detail, and we state some properties of this part of the model. In the bicriteria model we minimize the weighted sum of the two criteria...

  10. A simple but usually fast branch-and-bound algorithm for the capacitated facility location problem

    DEFF Research Database (Denmark)

    Görtz, Simon; Klose, Andreas

    2012-01-01

    This paper presents a simple branch-and-bound method based on Lagrangean relaxation and subgradient optimization for solving large instances of the capacitated facility location problem (CFLP) to optimality. To guess a primal solution to the Lagrangean dual, we average solutions to the Lagrangean...

  11. 77 FR 23409 - Toxics Release Inventory (TRI) Reporting for Facilities Located in Indian Country and...

    Science.gov (United States)

    2012-04-19

    ..., because tribal governmental structures may vary, EPA is updating its terminology to refer to the principal..., so as to avoid any confusing overlap in terminology for facilities located in Indian country. With... rule to include ceded territories used for hunting, fishing, and gathering. Other commenters...

  12. A simple dual ascent algorithm for the multilevel facility location problem

    NARCIS (Netherlands)

    Bumb, Adriana; Kern, Walter; Goemans, Michel; Jansen, Klaus; Rolim, José D.P.; Trevisan, Luca

    2001-01-01

    We present a simple dual ascent method for the multilevel facility location problem which finds a solution within 6 times the optimum for the uncapacitated case and within 12 times the optimum for the capacitated one. The algorithm is deterministic and based on the primal-dual technique.

  13. A subgradient-based branch-and-bound algorithm for the capacitated facility location problem

    DEFF Research Database (Denmark)

    Görtz, Simon; Klose, Andreas

    This paper presents a simple branch-and-bound method based on Lagrangean relaxation and subgradient optimization for solving large instances of the capacitated facility location problem (CFLP) to optimality. In order to guess a primal solution to the Lagrangean dual, we average solutions...

  14. Location Optimization of Urban Mining Facilities with Maximal Covering Model in GIS: A Case of China

    NARCIS (Netherlands)

    Xue, Yanyan; Wen, Zongguo; Ji, Xiaoli; Bressers, Johannes T.A.; Zhang, Chenkai

    2016-01-01

    Urban mining offers an efficient supply of resources because of rich mines and low environmental impacts. Location selection and optimization for urban mining facilities is more complicated than for natural mines, given that it may vary according to the urban population, consumption habits, and

  15. An improved cut-and-solve algorithm for the single-source capacitated facility location problem

    DEFF Research Database (Denmark)

    Gadegaard, Sune Lauth; Klose, Andreas; Nielsen, Lars Relund

    2017-01-01

    In this paper, we present an improved cut-and-solve algorithm for the single-source capacitated facility location problem. The algorithm consists of three phases. The first phase strengthens the integer program by a cutting plane algorithm to obtain a tight lower bound. The second phase uses a two...

  16. Cost Reduction Ability by Electricity Tariff Selection for Construction Facilities Located in Non-price Areas

    Directory of Open Access Journals (Sweden)

    Makasheva Svetlana

    2016-01-01

    Full Text Available State of the art in the tariff type selection in the retail and the wholesale electricity market for construction or reconstruction facilities located at Far East are considered. As a management solution the electricity tariff’s selection for enterprises at stage of construction or reconstruction is accented.

  17. Location Optimization of Urban Mining Facilities with Maximal Covering Model in GIS: A Case of China

    NARCIS (Netherlands)

    Xue, Yanyan; Wen, Zongguo; Ji, Xiaoli; Bressers, Hans Th.A.; Zhang, Chenkai

    2016-01-01

    Urban mining offers an efficient supply of resources because of rich mines and low environmental impacts. Location selection and optimization for urban mining facilities is more complicated than for natural mines, given that it may vary according to the urban population, consumption habits, and econ

  18. A cross-monotonic cost sharing method for the facility location game with service installation costs

    Institute of Scientific and Technical Information of China (English)

    XU DaChuan

    2009-01-01

    In this paper, we consider the metric uncapacitated facility location game with service installation costs. Our main result is an 11-approximate cross-monotonic cost-sharing method under the assumption that the installation cost depends only on the service type.

  19. A cross-monotonic cost sharing method for the facility location game with service installation costs

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this paper,we consider the metric uncapacitated facility location game with service installation costs. Our main result is an 11-approximate cross-monotonic cost-sharing method under the assumption that the installation cost depends only on the service type.

  20. A subgradient-based branch-and-bound algorithm for the capacitated facility location problem

    DEFF Research Database (Denmark)

    Görtz, Simon; Klose, Andreas

    This paper presents a simple branch-and-bound method based on Lagrangean relaxation and subgradient optimization for solving large instances of the capacitated facility location problem (CFLP) to optimality. In order to guess a primal solution to the Lagrangean dual, we average solutions...

  1. An Optimal Bifactor Approximation Algorithm for the Metric Uncapacitated Facility Location Problem

    NARCIS (Netherlands)

    Byrka, J.; Aardal, K.I.

    2010-01-01

    We obtain a 1.5-approximation algorithm for the metric uncapacitated facility location (UFL) problem, which improves on the previously best known 1.52-approximation algorithm by Mahdian, Ye, and Zhang. Note that the approximability lower bound by Guha and Khuller is 1.463 . . . . An algorithm is a (

  2. On locating a semi-desirable facility on the continuous plane

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik

    1998-01-01

    The paper considers a bicriteria model for locating a semi-desirable facility on the plane. One criterion is that of minimizing the sum of weighted distances between customers and facility, where distances are given by an arbitrary norm. The other criterion is that of maximizing the weighted...... Euclidean distance from the facility to the closest customer. The objective is to generate the set of efficient points, from which the decision maker must choose the preferred one. Two reformulations are considered: in one, the sum of weighted distances is minimized, subject to constraints requiring...... that each customer must have a weighted Euclidean distance to the facility of at least a given parameter; varying the parameter yields the efficient set. In the other, both criteria are viewed as minimization problems and a convex combination of them is minimized. Properties of the reformulations are given...

  3. On locating a semi-desirable facility on the continuous plane

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik

    1998-01-01

    The paper considers a bicriteria model for locating a semi-desirable facility on the plane. One criterion is that of minimizing the sum of weighted distances between customers and facility, where distances are given by an arbitrary norm. The other criterion is that of maximizing the weighted...... Euclidean distance from the facility to the closest customer. The objective is to generate the set of efficient points, from which the decision maker must choose the preferred one. Two reformulations are considered: in one, the sum of weighted distances is minimized, subject to constraints requiring...... that each customer must have a weighted Euclidean distance to the facility of at least a given parameter; varying the parameter yields the efficient set. In the other, both criteria are viewed as minimization problems and a convex combination of them is minimized. Properties of the reformulations are given...

  4. Online optimisation of the CLIC Drive Beam bunch train recombination at CTF3

    CERN Document Server

    AUTHOR|(CDS)2082483; Tecker, Frank

    The Compact Linear Collider (CLIC) design is the leading alternative for a future multi-TeV "e^+e^−" linear collider. One of the key aspects of the design is the use of a Drive Beam as power source for the acceleration of the colliding beams. This work is focused on the optimisation of the set-up and the operations of the CLIC Drive Beam recombination at the CLIC Test Facility (CTF3) at CERN. The main effects that may affect the beam quality during the recombination are studied, with emphasis on orbit, transverse dynamics and beam energy effects. A custom methodology is used to analyse the problem, both from a theoretical and a numerical point of view. The aim is to provide first-order orbit and transverse optics constraints, which can be used as guidelines during the set-up of the beam recombination process. The developed techniques are applied at the CTF3, and the results are reported. The non-linear beam energy effects have been investigated by means of MAD-X simulations. The results show that these effe...

  5. Conserved interaction of Ctf18-RFC with DNA polymerase ε is critical for maintenance of genome stability in Saccharomyces cerevisiae.

    Science.gov (United States)

    Okimoto, Hiroko; Tanaka, Seiji; Araki, Hiroyuki; Ohashi, Eiji; Tsurimoto, Toshiki

    2016-05-01

    Human Ctf18-RFC, a PCNA loader complex, interacts with DNA polymerase ε (Polε) through a structure formed by the Ctf18, Dcc1 and Ctf8 subunits. The C-terminal stretch of Ctf18, which is highly conserved from yeast to human, is necessary to form the Polε-capturing structure. We found that in the budding yeast Saccharomyces cerevisiae, Ctf18, Dcc1 and Ctf8 formed the same structure through the conserved C-terminus and interacted specifically with Polε. Thus, the specific interaction of Ctf18-RFC with Polε is a conserved feature between these proteins. A C-terminal deletion mutant of Ctf18 (ctf18(ΔC) ) exhibited the same high sensitivity to hydroxyurea as the complete deletion strain (ctf18Δ) or ATPase-deficient mutant (ctf18(K189A) ), but was somewhat less sensitive to methyl methanesulfonate than either of them. These phenotypes were also observed in dcc1Δ and ctf8Δ, predicted to be deficient in the interaction with Polε. Furthermore, both plasmid loss and gross chromosomal rearrangement (GCR) rates were increased in ctf18(ΔC) cells to the same extent as in ctf18Δ cells. These results indicate that the Ctf18-RFC/Polε interaction plays a crucial role in maintaining genome stability in budding yeast, probably through recruitment of this PCNA loader to the replication fork.

  6. Accreditation status and geographic location of outpatient vascular testing facilities among Medicare beneficiaries: the VALUE (Vascular Accreditation, Location & Utilization Evaluation) study.

    Science.gov (United States)

    Rundek, Tatjana; Brown, Scott C; Wang, Kefeng; Dong, Chuanhui; Farrell, Mary Beth; Heller, Gary V; Gornik, Heather L; Hutchisson, Marge; Needleman, Laurence; Benenati, James F; Jaff, Michael R; Meier, George H; Perese, Susana; Bendick, Phillip; Hamburg, Naomi M; Lohr, Joann M; LaPerna, Lucy; Leers, Steven A; Lilly, Michael P; Tegeler, Charles; Alexandrov, Andrei V; Katanick, Sandra L

    2014-10-01

    There is limited information on the accreditation status and geographic distribution of vascular testing facilities in the US. The Centers for Medicare & Medicaid Services (CMS) provide reimbursement to facilities regardless of accreditation status. The aims were to: (1) identify the proportion of Intersocietal Accreditation Commission (IAC) accredited vascular testing facilities in a 5% random national sample of Medicare beneficiaries receiving outpatient vascular testing services; (2) describe the geographic distribution of these facilities. The VALUE (Vascular Accreditation, Location & Utilization Evaluation) Study examines the proportion of IAC accredited facilities providing vascular testing procedures nationally, and the geographic distribution and utilization of these facilities. The data set containing all facilities that billed Medicare for outpatient vascular testing services in 2011 (5% CMS Outpatient Limited Data Set (LDS) file) was examined, and locations of outpatient vascular testing facilities were obtained from the 2011 CMS/Medicare Provider of Services (POS) file. Of 13,462 total vascular testing facilities billing Medicare for vascular testing procedures in a 5% random Outpatient LDS for the US in 2011, 13% (n=1730) of facilities were IAC accredited. The percentage of IAC accredited vascular testing facilities in the LDS file varied significantly by US region, pfacilities that are IAC accredited is low and varies by region. Increasing the number of accredited vascular testing facilities to improve test quality is a hypothesis that should be tested in future research. © The Author(s) 2014.

  7. Solid waste facilities location using of analytical network process and data envelopment analysis approaches.

    Science.gov (United States)

    Khadivi, M R; Fatemi Ghomi, S M T

    2012-06-01

    Selection of the appropriate site for solid waste facilities is a complex problem and requires an extensive evaluation process, because it is very difficult to develop a selection criterion that can precisely describe the preference of one location over another. Therefore selection of these sites can be viewed as a multiple criteria decision-making or multiple attributes decision-making problem. For this purpose, we propose a technique that can effectively take managerial preferences and subjective data into consideration, along with quantitative factors. The tool proposed here relies on the use of the analytical network process (ANP) and to help integrate managerial evaluations into a more quantitatively based decision tool, data envelopment analysis (DEA) is applied. In this paper, a location selection procedure is presented to construct an undesirable facility applying ANP and DEA approaches in two stages. In the first stage ANP approach is used, results of this stage are inputs for the second stage. In this stage, DEA is applied to select the best location. Finally, to illustrate the proposed framework, at "Results and discussion" section, a total of four undesirable facility locations are evaluated. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Designing Multi Objective Facility Location Models Based on Multiple Type Facility Dispersion and Data Envelopment Analysis Using Fuzzy Goal Programing Approach

    OpenAIRE

    Mahdi Karbasian1; Mahdi Dashti

    2013-01-01

    In this paper, four different multiple-type dispersion facilities location modeling formulations have been developed, which utilize efficiency measures of Data Envelopment Analysis to find optimal and efficient facility location patterns. While the problems studied previously do not clearly indicate which candidate is elected by a unit, simultaneous DEA approach has been used for analysis. In these models, existing facilities are considered. These models with two objectives, considerabely mat...

  9. Solving the Bilevel Facility Location Problem under Preferences by a Stackelberg-Evolutionary Algorithm

    Directory of Open Access Journals (Sweden)

    José-Fernando Camacho-Vallejo

    2014-01-01

    Full Text Available This research highlights the use of game theory to solve the classical problem of the uncapacitated facility location optimization model with customer order preferences through a bilevel approach. The bilevel model provided herein consists of the classical facility location problem and an optimization of the customer preferences, which are the upper and lower level problems, respectively. Also, two reformulations of the bilevel model are presented, reducing it into a mixed-integer single-level problem. An evolutionary algorithm based on the equilibrium in a Stackelberg’s game is proposed to solve the bilevel model. Numerical experimentation is performed in this study and the results are compared to benchmarks from the existing literature on the subject in order to emphasize the benefits of the proposed approach in terms of solution quality and estimation time.

  10. Stochastic Multi-Commodity Facility Location Based on a New Scenario Generation Technique

    Science.gov (United States)

    Mahootchi, M.; Fattahi, M.; Khakbazan, E.

    2011-11-01

    This paper extends two models for stochastic multi-commodity facility location problem. The problem is formulated as two-stage stochastic programming. As a main point of this study, a new algorithm is applied to efficiently generate scenarios for uncertain correlated customers' demands. This algorithm uses Latin Hypercube Sampling (LHS) and a scenario reduction approach. The relation between customer satisfaction level and cost are considered in model I. The risk measure using Conditional Value-at-Risk (CVaR) is embedded into the optimization model II. Here, the structure of the network contains three facility layers including plants, distribution centers, and retailers. The first stage decisions are the number, locations, and the capacity of distribution centers. In the second stage, the decisions are the amount of productions, the volume of transportation between plants and customers.

  11. Decision support with respect to facility location and fleet composition for FoodBank Cape Town

    CSIR Research Space (South Africa)

    Lanz, EJ

    2011-09-01

    Full Text Available Facility Location Problems Vehicle Fleet Composition Current & Future Work What is Food Banking? Started by John van Hengel in late 1960s in Phoenix, Arizona, USA. Good food going to waste due to defect packaging or near expiration date. Distributed... algorithm for the capacitated clustering problem, International Transactions in Operational Research, 6, pp. 665|678. Labbe M, Peeters D & Thisse JF, 1995, Location on networks, chapter 7, pp. 551|617, Ball MO, Magnanti TL, Monma CL & Nemhauser GL (Eds...

  12. VERA 3.6 - CTF User's Manual

    Energy Technology Data Exchange (ETDEWEB)

    Avramova, Maria [North Carolina State Univ., Raleigh, NC (United States); Toptan, Aysenur [North Carolina State Univ., Raleigh, NC (United States); Porter, Nathan [North Carolina State Univ., Raleigh, NC (United States); Blyth, Taylor S. [Pennsylvania State Univ., University Park, PA (United States); Dances, Christopher A. [Pennsylvania State Univ., University Park, PA (United States); Gomez, Ana [Pennsylvania State Univ., University Park, PA (United States); Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wysocki, Aaron J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jernigan, Caleb [Holtec International, Marlton, NJ (United States); Kelly, Joeseph [U.S. Nuclear Regulatory Commission (NRC), Rockville, MD (United States)

    2017-04-01

    This document describes how to make a CTF input deck. A CTF input deck is organized into Card Groups and Cards. A Card Group is a collection of Cards. A Card is de ned as a line of input. Each Card may contain multiple data. A Card is terminated by making a new line. This document has been organized so that each Card Group is discussed in its own dedicated chapter. Each card is discused in its own dedicated section. Each data in the card is discussed in its own block. The block gives information about the data, including the number of the input, the title, a description of the meaning of the data, units, data type, and so on. An example block is shown below to discuss the meaning of each entry in the block.

  13. A facility location model for municipal solid waste management system under uncertain environment.

    Science.gov (United States)

    Yadav, Vinay; Bhurjee, A K; Karmakar, Subhankar; Dikshit, A K

    2017-12-15

    In municipal solid waste management system, decision makers have to develop an insight into the processes namely, waste generation, collection, transportation, processing, and disposal methods. Many parameters (e.g., waste generation rate, functioning costs of facilities, transportation cost, and revenues) in this system are associated with uncertainties. Often, these uncertainties of parameters need to be modeled under a situation of data scarcity for generating probability distribution function or membership function for stochastic mathematical programming or fuzzy mathematical programming respectively, with only information of extreme variations. Moreover, if uncertainties are ignored, then the problems like insufficient capacities of waste management facilities or improper utilization of available funds may be raised. To tackle uncertainties of these parameters in a more efficient manner an algorithm, based on interval analysis, has been developed. This algorithm is applied to find optimal solutions for a facility location model, which is formulated to select economically best locations of transfer stations in a hypothetical urban center. Transfer stations are an integral part of contemporary municipal solid waste management systems, and economic siting of transfer stations ensures financial sustainability of this system. The model is written in a mathematical programming language AMPL with KNITRO as a solver. The developed model selects five economically best locations out of ten potential locations with an optimum overall cost of [394,836, 757,440] Rs.(1) /day ([5906, 11,331] USD/day) approximately. Further, the requirement of uncertainty modeling is explained based on the results of sensitivity analysis. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Beam Tests of a Prototype Stripline Beam Position Monitoring System for the Drive Beam of the CLIC Two-beam Module at CTF3

    CERN Document Server

    Benot-Morell, Alfonso; Nappa, Jean-Marc; Vilalte, Sebastien; Wendt, Manfred

    2016-01-01

    In collaboration with LAPP and IFIC, two units of a prototype stripline Beam Position Monitor (BPM) for the CLIC Drive Beam (DB), and its associated readout electronics have been successfully installed and tested in the Two-Beam-Module (TBM) at the CLIC Test Facility 3 (CTF3) at CERN. This paper gives a short overview of the BPM system and presents the performance measured under different Drive Beam configurations.

  15. GIS based location optimization for mobile produced water treatment facilities in shale gas operations

    Science.gov (United States)

    Kitwadkar, Amol Hanmant

    Over 60% of the nation's total energy is supplied by oil and natural gas together and this demand for energy will continue to grow in the future (Radler et al. 2012). The growing demand is pushing the exploration and exploitation of onshore oil and natural gas reservoirs. Hydraulic fracturing has proven to not only create jobs and achieve economic growth, but also has proven to exert a lot of stress on natural resources---such as water. As water is one of the most important factors in the world of hydraulic fracturing, proper fluids management during the development of a field of operation is perhaps the key element to address a lot of these issues. Almost 30% of the water used during hydraulic fracturing comes out of the well in the form of flowback water during the first month after the well is fractured (Bai et. al. 2012). Handling this large amount of water coming out of the newly fractured wells is one of the major issues as the volume of the water after this period drops off and remains constant for a long time (Bai et. al. 2012) and permanent facilities can be constructed to take care of the water over a longer period. This paper illustrates development of a GIS based tool for optimizing the location of a mobile produced water treatment facility while development is still occurring. A methodology was developed based on a multi criteria decision analysis (MCDA) to optimize the location of the mobile treatment facilities. The criteria for MCDA include well density, ease of access (from roads considering truck hauls) and piping minimization if piping is used and water volume produced. The area of study is 72 square miles east of Greeley, CO in the Wattenberg Field in northeastern Colorado that will be developed for oil and gas production starting in the year 2014. A quarterly analysis is done so that we can observe the effect of future development plans and current circumstances on the location as we move from quarter to quarter. This will help the operators to

  16. Strategic closed-loop facility location problem with carbon market trading

    DEFF Research Database (Denmark)

    Diabat, A.; Abdallah, T.; Al-Refaie, A.

    2013-01-01

    and recovery of products in a closed-loop configuration. Remanufacturing is the basis of profit-oriented reverse logistics in which recovered products are restored to a marketable condition in order to be resold to the primary or secondary market. In this paper, we introduce a multiechelon multicommodity...... facility location problem with a trading price of carbon emissions and a cost of procurement. The company might either incur costs if the carbon cap, normally assigned by regulatory agencies, is lower than the total emissions, or gain profit if the carbon cap is higher than the total emissions. A numerical...

  17. Inferring Groups of Objects, Preferred Routes, and Facility Locations from Trajectories

    DEFF Research Database (Denmark)

    Ceikute, Vaida

    on empirical studies with real route usage data and an existing online routing service. Finally, we use GPS trajectories as customer flows in a modern formulation of the facility location problem. We propose a practical framework that, given a road network, a set of trajectories, and a set of existing......In today’s society, GPS-enabled devices are used widely. A broad range of location-based services (LBS) allow users to receive and share information related to their positions. Thus, it is possible to accumulate GPS data, and it is expected that the amount of available GPS data will increase very...... substantially in the years to come. The availability of such GPS data holds huge potential to improve existing LBS or lead to the creation of new ones. This thesis investigates the use of GPS data in three different areas. Specifically, from GPS data we obtain trajectories of moving objects, from which we can...

  18. Special case waste located at Oak Ridge National Laboratory facilities: Survey report

    Energy Technology Data Exchange (ETDEWEB)

    Forgy, J.R. Jr.

    1995-11-01

    Between October 1994 and October 1995, a data base was established at the Oak Ridge National Laboratory (ORNL) to provide a current inventory of the radioactive waste materials, located at ORNL, for which the US Department of Energy (DOE) has no definite planned disposal alternatives. DOE refers to these waste materials as special case waste. To assist ORNL and DOE management in future planning, an inventory system was established and a baseline inventory prepared. This report provides the background of the ORNL special case waste survey project, as well as special case waste category definitions, both current and anticipated sources and locations of special case waste materials, and the survey and data management processes. Special case waste will be that waste material which, no matter how much practical characterization, treatment, and packaging is made, will never meet the acceptance criteria for permanent disposal at ORNL, and does not meet the criteria at a currently planned off-site permanent disposal facility.

  19. An Application Of Facility Location Models With Hotspot Analysis For Optimal Location Of Abattoir Bio-Energy Plant In Anambra State Of Nigeria

    Directory of Open Access Journals (Sweden)

    E. C. Chukwuma

    2015-08-01

    Full Text Available Poor waste management strategy in abattoir in the the study area has needs a major attention considering it negative impacts on man land and water. Sitting of centralized biogas plant in a strategic location in the state would be the major means of combating the environmental challenges of increase in abattoir waste generation as result of population explosion in the state. This study investigates optimal location for sitting central abattoir waste treatment facility in Anambra State of Nigeria using facility location models with hotspot analysis in GIS environment. The result of the study shows that Using centre of gravity model the central location was estimated to be at Xc Yc 6.900953016 6.110157865. Based on inadequacy of the model hotspot analysis operation was done the hotspot analysis delineated clusters of abattoirs significantly higher in bio-wastes production than the overall study area. The hotspot analysis shows that the West regions of the study area has many abattoir that is classified as hotspot abattoirs. Using the hotspot abattoirs as proposed sites for load-distance model three abattoirs were identified as proposed sites- Obosi slaugher house Nkpor Private slaughter house and Oye-olise Ogbunike slaugher house. Their load distance values are 17250.40058 16299.24005 and 18210.14631 respectively. The optimal location for construction of central abattoir bio-waste treatment facility based on the application of these location facility models and hotspot analysis is Nkpor private slaughter house or its environs.

  20. A NESTED PARTITIONS FRAMEWORK FOR SOLVING LARGE-SCALE MULTICOMMODITY FACILITY LOCATION PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Leyuan SHI; Robert R.MEYER; Mehmet BOZBAY; Andrew J.MILLER

    2004-01-01

    Large-scale multicommodity facility location problems are generally intractable with respect to standard mixed-integer programming (MIP) tools such as the direct application of general-purpose Branch & Cut (BC) commercial solvers i.e. CPLEX. In this paper, the authors investigate a nested partitions (NP) framework that combines meta-heuristics with MIP tools (including branch-and-cut).We also consider a variety of alternative formulations and decomposition methods for this problem class. Our results show that our NP framework is capable of efficiently producing very high quality solutions to multicommodity facility location problems. For large-scale problems in this class, this approach is significantly faster and generates better feasible solutions than either CPLEX (applied directly to the given MIP) or the iterative Lagrangian-based methods that have generally been regarded as the most effective structure-based techniques for optimization of these problems. We also briefly discuss some other large-scale MIP problem classes for which this approach is expected to be very effective.

  1. Beam Dynamics for the CTF3 Preliminary Phase

    CERN Document Server

    Corsini, R; Rinolfi, Louis; Risselada, Thys; Royer, P; Tecker, F A

    2001-01-01

    In the framework of the CLIC RF power source studies, the new scheme of electron pulse compression and bunch frequency multiplication, using injection by RF deflectors into an isochronous ring, will be tested at CERN during the CTF3 preliminary phase. The present LPI complex will be modified in order to allow a test of this scheme at low charge. The design of the new front-end, of the modified linac, of the matched transfer line, and of the isochronous ring lattice is presented here.The results of the related beam dynamics studies are also discussed.

  2. A Decision Framework for Location Selection in Thailand: A Case Study in Hard Disk Drive Manufacturing Facility Location

    OpenAIRE

    Bhumipipatana, Kanitsaran

    2010-01-01

    ABSTRACT Making location selection for the operation of products is a complex decision-making process for manufacturing firms since the optimal location could enhance the firms’ competitive advantage and lead to a success in business. In this study, the critical factors affecting foreign firms’ international location decision are explored and aggregated into a comprehensive set of main factors and sub-factors. The results are examined by looking at the group sample of the Hard Disk Drive ...

  3. The spatial and urban planning concerns related to nuclear facilities locations: Case study of the Vinča Institute location

    Directory of Open Access Journals (Sweden)

    Stefanović Nebojša D.

    2017-01-01

    Full Text Available The spatial and urban planning is one of the key instruments for the planned formation and development of locations for nuclear facilities, especially in terms of meeting the strict spatial conditionality, as well as in terms of the formation of protection zones in their surroundings. This paper systemizes the international criteria and requirements for the locations of nuclear facilities and analyses the spatial distribution of nuclear facilities in the surrounding countries of the Republic of Serbia. The research was conducted on the example of the location of the Vinča Institute of Nuclear Sciences, within which the fulfilment of spatial requirements, treatment of the location in the existing spatial and urban plans and relationship between other functions in the surrounding area were analysed. The paper proves the starting hypothesis that the general requirements related to both the spatial development of nuclear facilities locations and the protection from radiation have not been met in the Vinča location and its surroundings. It was determined that the spatial and urban plans encompassing the area of Vinča do not contain sufficiently specific planning solutions and that, as such, they do not provide a sufficient planning basis for meeting the necessary requirements and obligations regarding the protection from radiation. The paper also gives recommendations for further spatial development and protection of the Vinča location and its surroundings. The research condcted in this paper indicates the importance and priority of further research so that the necessary planning solutions for further development of the complex in Vinča and for the formation of protection zones could be defined through creating a new planning documentation. In addition, the paper particularly highlights the need for conducting a research to identify a location for permanent disposal of radioactive waste. It also indicates the necessity of considering the aspects

  4. The PHIN photoinjector for the CTF3 Drive beam

    CERN Document Server

    Losito, R; Braun, H; Champault, N; Chevallay, E; Divall, M; Fedosseev, V; Hirst, G; Kumar, A; Kurdi, G; Martin, W; Masi, A; Mercier, B; Musgrave, I; Prevost, C; Ross, I; Roux, R; Springate, E; Suberlucq, Guy

    2006-01-01

    A new photoinjector for the CTF3 drive beam has been designed and is now being constructed by a collaboration among LAL, CCLRC and CERN within PHIN, the second Joint Research Activity of CARE. The photoinjector will provide a train of 2332 pulses at 1.5 GHz with a complex timing structure (sub-trains of 212 pulses spaced from one another by 333 ps or 999 ps) to allow the frequency multiplication scheme, which is one of the features of CLIC, to be tested in CTF3. Each pulse of 2.33 nC will be emitted by a Cs2Te photocathode deposited by a co-evaporation process to allow high quantum efficiency in operation (>3% for a minimum of 40 h). The 3 GHz, 2 1/2 cell RF gun has a 2 port coupler to minimize emittance growth due to asymmetric fields, racetrack profile of the irises and two solenoids to keep the emittance at the output below 20 p.mm.mrad. The laser has to survive very high average powers both within the pulse train (15 kW) and overall (200 W before pulse slicing). Challenging targets are also for amplitude ...

  5. A branch-and-price algorithm for the capacitated facility location problem

    DEFF Research Database (Denmark)

    Klose, Andreas; Görtz, Simon

    2007-01-01

    to compute optimal solutions to large or difficult problem instances by means of a branch-and-bound procedure information about such a primal fractional solution can be advantageous. In this paper, a (stabilized) column generation method is, therefore, employed in order to solve a corresponding master......The capacitated facility location problem (CFLP) is a well-known combinatorial optimization problem with applications in distribution and production planning. It consists in selecting plant sites from a finite set of potential sites and in allocating customer demands in such a way as to minimize...... operating and transportation costs. A number of solution approaches based on Lagrangean relaxation and subgradient optimization has been proposed for this problem. Subgradient optimization does not provide a primal (fractional) optimal solution to the corresponding master problem. However, in order...

  6. CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Kouprina, N; Kroll, E; Bannikov, V; Bliskovsky, V; Gizatullin, R; Kirillov, A; Shestopalov, B; Zakharyev, V; Hieter, P; Spencer, F

    1992-12-01

    We have analyzed the CTF4 (CHL15) gene, earlier identified in two screens for yeast mutants with increased rates of mitotic loss of chromosome III and artificial circular and linear chromosomes. Analysis of the segregation properties of circular minichromosomes and chromosome fragments indicated that sister chromatid loss (1:0 segregation) is the predominant mode of chromosome destabilization in ctf4 mutants, though nondisjunction events (2:0 segregation) also occur at an increased rate. Both inter- and intrachromosomal mitotic recombination levels are elevated in ctf4 mutants, whereas spontaneous mutation to canavanine resistance was not elevated. A genomic clone of CTF4 was isolated and used to map its physical and genetic positions on chromosome XVI. Nucleotide sequence analysis of CTF4 revealed a 2.8-kb open reading frame with a 105-kDa predicted protein sequence. The CTF4 DNA sequence is identical to that of POB1, characterized as a gene encoding a protein that associates in vitro with DNA polymerase alpha. At the N-terminal region of the protein sequence, zinc finger motifs which define potential DNA-binding domains were found. The C-terminal region of the predicted protein displayed similarity to sequences of regulatory proteins known as the helix-loop-helix proteins. Data on the effects of a frameshift mutation suggest that the helix-loop-helix domain is essential for CTF4 function. Analysis of sequences upstream of the CTF4 open reading frame revealed the presence of a hexamer element, ACGCGT, a sequence associated with many DNA metabolism genes in budding yeasts. Disruption of the coding sequence of CTF4 did not result in inviability, indicating that the CTF4 gene is nonessential for mitotic cell division. However, ctf4 mutants exhibit an accumulation of large budded cells with the nucleus in the neck. ctf4 rad52 double mutants grew very slowly and produced extremely high levels (50%) of inviable cell division products compared with either single mutant

  7. A simulation-based robust biofuel facility location model for an integrated bio-energy logistics network

    Directory of Open Access Journals (Sweden)

    Jae-Dong Hong

    2014-10-01

    Full Text Available Purpose: The purpose of this paper is to propose a simulation-based robust biofuel facility location model for solving an integrated bio-energy logistics network (IBLN problem, where biomass yield is often uncertain or difficult to determine.Design/methodology/approach: The IBLN considered in this paper consists of four different facilities: farm or harvest site (HS, collection facility (CF, biorefinery (BR, and blending station (BS. Authors propose a mixed integer quadratic modeling approach to simultaneously determine the optimal CF and BR locations and corresponding biomass and bio-energy transportation plans. The authors randomly generate biomass yield of each HS and find the optimal locations of CFs and BRs for each generated biomass yield, and select the robust locations of CFs and BRs to show the effects of biomass yield uncertainty on the optimality of CF and BR locations. Case studies using data from the State of South Carolina in the United State are conducted to demonstrate the developed model’s capability to better handle the impact of uncertainty of biomass yield.Findings: The results illustrate that the robust location model for BRs and CFs works very well in terms of the total logistics costs. The proposed model would help decision-makers find the most robust locations for biorefineries and collection facilities, which usually require huge investments, and would assist potential investors in identifying the least cost or important facilities to invest in the biomass and bio-energy industry.Originality/value: An optimal biofuel facility location model is formulated for the case of deterministic biomass yield. To improve the robustness of the model for cases with probabilistic biomass yield, the model is evaluated by a simulation approach using case studies. The proposed model and robustness concept would be a very useful tool that helps potential biofuel investors minimize their investment risk.

  8. Characterization of the Old Hydrofracture Facility (OHF) waste tanks located at ORNL

    Energy Technology Data Exchange (ETDEWEB)

    Keller, J.M.; Giaquinto, J.M.; Meeks, A.M.

    1997-04-01

    The Old Hydrofracture Facility (OHF) is located in Melton Valley within Waste Area Grouping (WAG) 5 and includes five underground storage tanks (T1, T2, T3, T4, and T9) ranging from 13,000 to 25,000 gal. capacity. During the period of 1996--97 there was a major effort to re-sample and characterize the contents of these inactive waste tanks. The characterization data summarized in this report was needed to address waste processing options, examine concerns dealing with the performance assessment (PA) data for the Waste Isolation Pilot Plant (WIPP), evaluate the waste characteristics with respect to the waste acceptance criteria (WAC) for WIPP and Nevada Test Site (NTS), address criticality concerns, and to provide the data needed to meet DOT requirements for transporting the waste. This report discusses the analytical characterization data collected on both the supernatant and sludge samples taken from three different locations in each of the OHF tanks. The isotopic data presented in this report supports the position that fissile isotopes of uranium ({sup 233}U and {sup 235}U) do not satisfy the denature ratios required by the administrative controls stated in the ORNL LLLW waste acceptance criteria (WAC). The fissile isotope of plutonium ({sup 239}Pu and {sup 241}Pu) are diluted with thorium far above the WAC requirements. In general, the OHF sludge was found to be hazardous (RCRA) based on total metal content and the transuranic alpha activity was well above the 100 nCi/g limit for TRU waste. The characteristics of the OHF sludge relative to the WIPP WAC limits for fissile gram equivalent, plutonium equivalent activity, and thermal power from decay heat were estimated from the data in this report and found to be far below the upper boundary for any of the remote-handled transuranic waste (RH-TRU) requirements for disposal of the waste in WIPP.

  9. Mine-detection test facilities at TNO-FEL test location "Waalsdorp"

    NARCIS (Netherlands)

    Rhebergen, J.B.; Zwamborn, A.P.M.

    1998-01-01

    As part of the TNO-FEL Ultra-Wide-Band Ground-Penetrating-Radar (UWB-GPR) project, a test facility for controlled GPR experiments was planned. Construction of this sand-box test facility has recently been completed. At the same site another test facility, for evaluating various commercial of the

  10. Mine-detection test facilities at TNO-FEL test location "Waalsdorp"

    NARCIS (Netherlands)

    Rhebergen, J.B.; Zwamborn, A.P.M.

    1998-01-01

    As part of the TNO-FEL Ultra-Wide-Band Ground-Penetrating-Radar (UWB-GPR) project, a test facility for controlled GPR experiments was planned. Construction of this sand-box test facility has recently been completed. At the same site another test facility, for evaluating various commercial of the she

  11. Designing Multi Objective Facility Location Models Based on Multiple Type Facility Dispersion and Data Envelopment Analysis Using Fuzzy Goal Programing Approach

    Directory of Open Access Journals (Sweden)

    Mahdi Karbasian

    2013-01-01

    Full Text Available In this paper, four different multiple-type dispersion facilities location modeling formulations have been developed, which utilize efficiency measures of Data Envelopment Analysis to find optimal and efficient facility location patterns. While the problems studied previously do not clearly indicate which candidate is elected by a unit, simultaneous DEA approach has been used for analysis. In these models, existing facilities are considered. These models with two objectives, considerabely match the real world problems. Since these four models are multiobjective, a fuzzy goal programming approach has been applied to solve the four problems. In this paper, after introducing the proposed models, an example, with the results of numerical calculations has been presented.

  12. Accreditation Status and Geographic Location of Outpatient Echocardiographic Testing Facilities Among Medicare Beneficiaries: The VALUE-ECHO Study.

    Science.gov (United States)

    Brown, Scott C; Wang, Kefeng; Dong, Chuanhui; Yi, Li; Marinovic Gutierrez, Carolina; Di Tullio, Marco R; Farrell, Mary Beth; Burgess, Pamela; Gornik, Heather L; Hamburg, Naomi M; Needleman, Laurence; Orsinelli, David; Robison, Susana; Rundek, Tatjana

    2017-08-08

    Accreditation of echocardiographic testing facilities by the Intersocietal Accreditation Commission (IAC) is supported by the American College of Cardiology and American Society of Echocardiography. However, limited information exists on the accreditation status and geographic distribution of echocardiographic facilities in the United States. Our study aimed to identify (1) the proportion of outpatient echocardiography facilities used by Medicare beneficiaries that are IAC accredited, (2) their geographic distribution, and (3) variations in procedure type and volume by accreditation status. As part of the VALUE-ECHO (Value of Accreditation, Location, and Utilization Evaluation-Echocardiography) study, we examined the proportion of IAC-accredited echocardiographic facilities performing outpatient echocardiography in the 2013 Centers for Medicare and Medicaid Services outpatient limited data set (100% sample) and their geographic distribution using geocoding in ArcGIS (ESRI, Redlands, CA). Among 4573 outpatient facilities billing Medicare for echocardiographic testing in 2013, 99.6% (n = 4554) were IAC accredited (99.7% in the 50 US states and 86.2% in Puerto Rico). The proportion IAC-accredited echocardiographic facilities varied by region, with 98.7%, 99.9%, 99.9%, 99.5%, and 86.2% of facilities accredited in the Northeast, South, Midwest, West, and Puerto Rico, respectively (P facilities. Most procedures (90.9%) were transthoracic echocardiograms, of which 99.7% were conducted in IAC-accredited echocardiographic facilities. Almost all outpatient echocardiographic facilities billed by Medicare are IAC accredited. This accreditation rate is substantially higher than previously reported for US outpatient vascular testing facilities (13% IAC accredited). The uniformity of imaging and interpretation protocols from a single accrediting body is important to facilitate optimal cardiovascular care. © 2017 by the American Institute of Ultrasound in Medicine.

  13. Effect of p95HER2/611CTF on the response to trastuzumab and chemotherapy.

    Science.gov (United States)

    Parra-Palau, Josep Lluís; Morancho, Beatriz; Peg, Vicente; Escorihuela, Marta; Scaltriti, Maurizio; Vicario, Rocio; Zacarias-Fluck, Mariano; Pedersen, Kim; Pandiella, Atanasio; Nuciforo, Paolo; Serra, Violeta; Cortés, Javier; Baselga, José; Perou, Charles M; Prat, Aleix; Rubio, Isabel T; Arribas, Joaquín

    2014-11-01

    Human epidermal growth factor receptor 2 (HER2)-positive breast cancers are currently treated with trastuzumab, an anti-HER2 antibody. About 30% of these tumors express a group of HER2 fragments collectively known as p95HER2. Our previous work indicated that p95HER2-positive tumors are resistant to trastuzumab monotherapy. However, recent results showed that tumors expressing the most active of these fragments, p95HER2/611CTF, respond to trastuzumab plus chemotherapy. To clarify this discrepancy, we analyzed the response to chemotherapy of cell lines transfected with p95HER2/611CTF and patient-derived xenografts (n = 7 mice per group) with different levels of the fragment. All statistical tests were two-sided. p95HER2/611CTF-negative and positive tumors showed different responses to various chemotherapeutic agents, which are particularly effective on p95HER2/611CTF-positive cells. Furthermore, chemotherapy sensitizes p95HER2/611CTF-positive patient-derived xenograft tumors to trastuzumab (mean tumor volume, trastuzumab alone: 906 mm(3), 95% confidence interval = 1274 to 538 mm(3); trastuzumab+doxorubicin: 259 mm(3), 95% confidence interval = 387 to 131 mm(3); P chemotherapy in p95HER2/611CTF-positive cells. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  14. L3.PHI.CTF.P10.02-rev2 Coupling of Subchannel T/H (CTF) and CRUD Chemistry (MAMBA1D)

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Palmtag, Scott [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Collins, Benjamin S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kendrick, Brian [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Seker, Jeffrey [Westinghouse Electric Company LLC, Cranberry Township, PA (United States)

    2015-05-15

    The purpose of this milestone is to create a preliminary capability for modeling light water reactor (LWR) thermal-hydraulic (T/H) and CRUD growth using the CTF subchannel code and the subgrid version of the MAMBA CRUD chemistry code, MAMBA1D. In part, this is a follow-on to Milestone L3.PHI.VCS.P9.01, which is documented in Report CASL-U-2014-0188-000, titled "Development of CTF Capability for Modeling Reactor Operating Cycles with Crud Growth". As the title suggests, the previous milestone set up a framework for modeling reactor operation cycles with CTF. The framework also facilitated coupling to a CRUD chemistry capability for modeling CRUD growth throughout the reactor operating cycle. To demonstrate the capability, a simple CRUD \\surrogate" tool was developed and coupled to CTF; however, it was noted that CRUD growth predictions by the surrogate were not considered realistic. This milestone builds on L3.PHI.VCS.P9.01 by replacing this simple surrogate tool with the more advanced MAMBA1D CRUD chemistry code. Completing this task involves addressing unresolved tasks from Milestone L3.PHI.VCS.P9.01, setting up an interface to MAMBA1D, and extracting new T/H information from CTF that was not previously required in the simple surrogate tool. Speci c challenges encountered during this milestone include (1) treatment of the CRUD erosion model, which requires local turbulent kinetic energy (TKE) (a value that CTF does not calculate) and (2) treatment of the MAMBA1D CRUD chimney boiling model in the CTF rod heat transfer solution. To demonstrate this new T/H, CRUD modeling capability, two sets of simulations were performed: (1) an 18 month cycle simulation of a quarter symmetry model of Watts Bar and (2) a simulation of Assemblies G69 and G70 from Seabrook Cycle 5. The Watts Bar simulation is merely a demonstration of the capability. The simulation of the Seabrook cycle, which had experienced CRUD-related fuel rod failures, had actual CRUD-scrape data to compare with

  15. Design, Manufacturing and Testing of the CTF3 Tail Clipper Kicker

    CERN Document Server

    Barnes, M J; Ravida, G; Rodriguez, I; Toral, F

    2010-01-01

    The goal of the present CLIC Test Facility (CTF3) is to demonstrate the technical feasibility of specific key issues of the CLIC scheme. The extracted drive beam from the combiner ring (CR), a pulse of 35 A magnitude and 140 ns duration, is sent to the new CLic EXperimental area (CLEX). A Tail Clipper (TC) kicker is required, in the CR to CLEX transfer line, to allow the duration of the beam pulse to be adjusted: the unwanted bunches are kicked into a collimator. The TC must have a fast field rise-time, of not more than 5 ns, in order to minimize uncontrolled beam loss. Striplines are used for the TC: to establish the required fields, the applied pulse wave front must fully propagate along the striplines. To reduce the wave front propagation time, the overall length of the stripline assembly is sub-divided into 4 sections. The TC has been designed with the aid of detailed numerical modelling: the stripline cross-section and coaxial-to-stripline transitions were carefully optimized using a 3D code. The results...

  16. Design, Testing and Operation of the Modulator for the CTF3 Tail Clipper Kicker

    CERN Document Server

    Barnes, M J; Ravida, G

    2010-01-01

    The goal of the present CLIC Test Facility (CTF3) is to demonstrate the technical feasibility of specific key issues in the CLIC scheme. The extracted drive beam from the combiner ring (CR, of 35 A magnitude and 140 ns duration, is sent to the new CLic EXperimental area (CLEX). A Tail Clipper (TC) is required, in the CR to CLEX transfer line, to allow the duration of the extracted beam pulse to be adjusted. Fours sets of striplines are used for the tail clipper, each consisting of a pair of deflector plates driven to equal potential but opposite polarity. The tail clipper kick must have a fast field risetime, of not more than 5 ns, in order to minimize uncontrolled beam loss. High voltage MOSFETs have been chosen to meet the demanding specifications for the semiconductor switches for the modulator of the tail clipper. This paper discusses the design of the modulator; measurement data obtained during testing and operation of the tail clipper is presented and analyzed.

  17. Optimizations of transverse projected emittance at the photo-injector test facility at DESY, location Zeuthen

    Energy Technology Data Exchange (ETDEWEB)

    Rimjaem, S., E-mail: r.sakhorn@gmail.com [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738 Zeuthen (Germany); Stephan, F.; Krasilnikov, M. [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738 Zeuthen (Germany); Ackermann, W. [Technische Universtaet Darmstadt, Schossgartenstrasse 8, 64289 Darmstadt (Germany); Asova, G.; Baehr, J. [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738 Zeuthen (Germany); Gjonaj, E. [Technische Universtaet Darmstadt, Schossgartenstrasse 8, 64289 Darmstadt (Germany); Grabosch, H.J.; Hakobyan, L.; Haenel, M.; Ivanisenko, Y.; Khojoyan, M.; Klemz, G. [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738 Zeuthen (Germany); Lederer, S. [Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607 Hamburg (Germany); Mahgoub, M. [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738 Zeuthen (Germany); Michelato, P.; Monaco, L. [Istituto Nazionale di Fisica Nucleare, Sezione di Milano - LASA, Via F.lli Cervi 201, 20090 Segrate Milano (Italy); Nozdrin, M.; O' Shea, B.; Otevrel, M. [Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738 Zeuthen (Germany); and others

    2012-04-11

    High brightness electron sources for linac based short-wavelength free-electron lasers are developed and optimized for small transverse projected emittance at the photo-injector test facility at DESY, location Zeuthen (PITZ). A major part of the measurement program at PITZ is dedicated to transverse phase space optimization in order to fulfill the requirements of the European X-ray free-electron laser (European XFEL). A laser-driven RF-gun, treated with a dry-ice sublimation-impulse cleaning technique, a new photocathode laser system allowing short rise and fall times of the flat-top temporal distribution as well as several new diagnostic components have been installed at PITZ in 2008. The electrons generated via the photo-effect at a cesium telluride (Cs{sub 2}Te) cathode are accelerated by a 1.6 cell L-band RF-gun cavity with a maximum accelerating gradient at the cathode of about 60 MV/m. The transverse projected emittance is measured using a single slit scan technique. In the 2008-2009 run period, a detailed characterization of the projected transverse emittance was performed at different operating conditions. Optimizations and measurement results as well as simulation predictions of the transverse projected emittance for bunch charges of 1, 0.5, 0.25 and 0.1 nC are presented and discussed in this paper. The geometric mean of the normalized projected rms emittance in both transverse directions for an electron bunch charge of 1 nC was measured to be 0.89{+-}0.01 mm mrad for a 100% rms phase-space distribution.

  18. Results of operation and current safety performance of nuclear facilities located in the Russian Federation

    Science.gov (United States)

    Kuznetsov, V. M.; Khvostova, M. S.

    2016-12-01

    After the NPP radiation accidents in Russia and Japan, a safety statu of Russian nuclear power plants causes concern. A repeated life time extension of power unit reactor plants, designed at the dawn of the nuclear power engineering in the Soviet Union, power augmentation of the plants to 104-109%, operation of power units in a daily power mode in the range of 100-70-100%, the use of untypical for NPP remixed nuclear fuel without a careful study of the results of its application (at least after two operating periods of the research nuclear installations), the aging of operating personnel, and many other management actions of the State Corporation "Rosatom", should attract the attention of the Federal Service for Ecological, Technical and Atomic Supervision (RosTekhNadzor), but this doesn't happen. The paper considers safety issues of nuclear power plants operating in the Russian Federation. The authors collected statistical information on violations in NPP operation over the past 25 years, which shows that even after repeated relaxation over this period of time of safety regulation requirements in nuclear industry and highly expensive NPP modernization, the latter have not become more safe, and the statistics confirms this. At a lower utilization factor high-power pressure-tube reactors RBMK-1000, compared to light water reactors VVER-440 and 1000, have a greater number of violations and that after annual overhauls. A number of direct and root causes of NPP mulfunctions is still high and remains stable for decades. The paper reveals bottlenecks in ensuring nuclear and radiation safety of nuclear facilities. Main outstanding issues on the storage of spent nuclear fuel are defined. Information on emissions and discharges of radioactive substances, as well as fullness of storages of solid and liquid radioactive waste, located at the NPP sites are presented. Russian NPPs stress test results are submitted, as well as data on the coming removal from operation of NPP

  19. Assessment Of Market Facilities And Locational Effects On Adjoining Neighborhoods In Nigerian Urban Centers Empirical Evidence From Akure Nigeria

    Directory of Open Access Journals (Sweden)

    Adeyinka S. A.

    2015-08-01

    Full Text Available There is the need for people to buy and sell and transact their businesses in a way that life can go on normally. This study examined the markets facilities level and locational effects on adjoining neighbourhoods in Akure Township. Both primary and secondary data types were employed in the study primary data were collected through the administration of questionnaire on traders and patronsbuyers in the markets and residents of adjoining neighbourhoods and personal observation. Secondary data were collected from government publications. Data collected were analysed using descriptive statistical methods which included frequency counts and Likerts scale to analyse the satisfaction of traders and patrons on the facilities in the markets and severity of locational effects on residents of adjoining neighbourhoods. Findings from the study showed that facilities such as parking spaces fire extinguishers circulation spaces within the markets trading spaces safe area for children perimeter fencing and loading and off-loading bay were inadequately provided. While on-street display of goods traffic congestion air pollution on-street parking due to inadequate parking spaces were the severely perceived locational effects. The study concluded that facilities in the markets were inadequate and that markets constitute nuisances to the adjoining areas. It hereby recommends that markets in the study area be provided with the required level of facilities to prevent future urban problems.

  20. Classifying substance use disorder treatment facilities with co-located mental health services: A latent class analysis approach.

    Science.gov (United States)

    Mauro, Pia M; Furr-Holden, C Debra; Strain, Eric C; Crum, Rosa M; Mojtabai, Ramin

    2016-06-01

    The Affordable Care Act calls for increased integration and coordination of behavioral health services, as people with co-occurring disorders (CODs), meeting criteria for both substance use and psychiatric disorders, are overrepresented in treatment samples. Nationwide estimates of mental health (MH) service co-location in substance use disorder (SUD) treatment facilities are needed. We empirically derived a multiple-indicator categorization of services for CODs in SUD treatment facilities. We used latent class analysis to categorize 14,037 SUD treatment facilities in the United States and territories included in the 2012 National Survey of Substance Abuse Treatment Services. Latent class indicators included MH screening and diagnosis, MH support services, psychiatric medications, groups for CODs, and psychosocial approaches. Multinomial logistic regression compared facility-identified primary focus (i.e., SUD, MH, mix of SUD-MH, and general/other) and other facility characteristics across classes. A four-class solution was chosen with the following classes: Comprehensive MH/COD Services (25%), MH without COD Services (25%), MH Screening Services (21%), and Limited MH Services (29%). The former two classes with co-located MH services were less likely to report a SUD-primary focus than the latter classes reporting only MH screening or Limited MH Services. Only the Comprehensive MH/COD Services class also had a high probability of providing special groups for CODs. Approximately half of SUD treatment facilities were in classes with co-located mental health services, but only a quarter provided comprehensive COD services. Future studies should assess differences in patient experiences and treatment outcomes across facilities with and without COD services. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

    Science.gov (United States)

    Gellon, Lionel; Razidlo, David F; Gleeson, Olive; Verra, Lauren; Schulz, Danae; Lahue, Robert S; Freudenreich, Catherine H

    2011-02-10

    Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilized in Saccharomyces cerevisiae by the alternative clamp loader/unloader Ctf18-Dcc1-Ctf8-RFC complex (Ctf18-RFC). Mutants in Ctf18-RFC increased all three forms of triplet repeat instability--expansions, contractions, and fragility--with effect over a wide range of allele lengths from 20-155 repeats. Ctf18-RFC predominated among the three alternative clamp loaders, with mutants in Elg1-RFC or Rad24-RFC having less effect on trinucleotide repeats. Surprisingly, chl1, scc1-73, or scc2-4 mutants defective in sister chromatid cohesion (SCC) did not increase instability, suggesting that Ctf18-RFC protects triplet repeats independently of SCC. Instead, three results suggest novel roles for Ctf18-RFC in facilitating genomic stability. First, genetic instability in mutants of Ctf18-RFC was exacerbated by simultaneous deletion of the fork stabilizer Mrc1, but suppressed by deletion of the repair protein Rad52. Second, single-cell analysis showed that mutants in Ctf18-RFC had a slowed S phase and a striking G2/M accumulation, often with an abnormal multi-budded morphology. Third, ctf18 cells exhibit increased Rad52 foci in S phase, often persisting into G2, indicative of high levels of DNA damage. The presence of a repeat tract greatly magnified the ctf18 phenotypes. Together these results indicate that Ctf18-RFC has additional important functions in preserving genome stability, besides its role in SCC, which we propose include lesion bypass by replication forks and post-replication repair.

  2. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

    Directory of Open Access Journals (Sweden)

    Lionel Gellon

    Full Text Available Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilized in Saccharomyces cerevisiae by the alternative clamp loader/unloader Ctf18-Dcc1-Ctf8-RFC complex (Ctf18-RFC. Mutants in Ctf18-RFC increased all three forms of triplet repeat instability--expansions, contractions, and fragility--with effect over a wide range of allele lengths from 20-155 repeats. Ctf18-RFC predominated among the three alternative clamp loaders, with mutants in Elg1-RFC or Rad24-RFC having less effect on trinucleotide repeats. Surprisingly, chl1, scc1-73, or scc2-4 mutants defective in sister chromatid cohesion (SCC did not increase instability, suggesting that Ctf18-RFC protects triplet repeats independently of SCC. Instead, three results suggest novel roles for Ctf18-RFC in facilitating genomic stability. First, genetic instability in mutants of Ctf18-RFC was exacerbated by simultaneous deletion of the fork stabilizer Mrc1, but suppressed by deletion of the repair protein Rad52. Second, single-cell analysis showed that mutants in Ctf18-RFC had a slowed S phase and a striking G2/M accumulation, often with an abnormal multi-budded morphology. Third, ctf18 cells exhibit increased Rad52 foci in S phase, often persisting into G2, indicative of high levels of DNA damage. The presence of a repeat tract greatly magnified the ctf18 phenotypes. Together these results indicate that Ctf18-RFC has additional important functions in preserving genome stability, besides its role in SCC, which we propose include lesion bypass by replication forks and post-replication repair.

  3. Environmental Monitoring, Air Quality - MO 2011 Facility Air Locations - Missouri Emmissions Inventory System (SHP)

    Data.gov (United States)

    NSGIC State | GIS Inventory — This data set includes locations from the Missouri Emissions Inventory System (MOEIS) database. Locational data was obtained using a variety of methods including but...

  4. EPA Facility Locations and Regional Boundaries - National Geospatial Data Asset (NGDA)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable package contains the following layers: EPA facility points, EPA region boundary polygons and EPA region boundary polygons extended to the 200nm...

  5. On (Group) Strategy-Proof Mechanisms without Payment for Facility Location Games

    DEFF Research Database (Denmark)

    Thang, Nguyen Kim

    2010-01-01

    in an allowable location that minimizes the utilitarian social cost — the sum of agents costs. A mechanism is strategyproof (SP) if no agent may misreport its locations and be better off; it is group-strategyproof (GSP) if no coalition of agents benefits by jointly misreporting their locations The requirement...

  6. Assisted Living Facilities, Locations of Assisted Living Facilities identifed visually and placed on the Medical Multi-Hazard Mitigation layer., Published in 2006, 1:1200 (1in=100ft) scale, Noble County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Assisted Living Facilities dataset current as of 2006. Locations of Assisted Living Facilities identifed visually and placed on the Medical Multi-Hazard Mitigation...

  7. Developing a plan for primary health care facilities in Soweto, South Africa. Part II: Applying locational criteria.

    Science.gov (United States)

    Doherty, J; Rispel, L; Webb, N

    1996-12-01

    This article is the second of a two-part series describing the development of a ten-year plan for primary health care facility development in Soweto. The first article concentrated on the political problems and general methodological approach of the project. This second article describes how the technical problem of planning in the context of scanty information was overcome. The reasoning behind the various assumptions and criteria which were used to assist the planning of the location of facilities is explained, as well as the process by which they were applied. The merits and limitations of this planning approach are discussed, and it is suggested that the approach may be useful to other facility planners, particularly in the developing world.

  8. Development and Testing of CTF to Support Modeling of BWR Operating Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Salko, Robert K. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wysocki, Aaron [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Collins, Benjamin S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Godfrey, Andrew T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gosdin, Chris [Pennsylvania State Univ., University Park, PA (United States); Avramova, Maria [North Carolina State Univ., Raleigh, NC (United States)

    2016-01-29

    This milestone supports developing and assessing COBRA-TF (CTF) for the modeling of boiling water reactors (BWRs). This is achieved in three stages. First, a new preprocessor utility that is capable of handling BWR-specic design elements (e.g., channel boxes and large water rods) is developed. A previous milestone (L3:PHI.CTF.P12.01) led to the development of this preprocessor capability for single assembly models. This current milestone expands this utility so that it is applicable to multi-assembly BWR models that can be modeled in either serial or parallel. The second stage involves making necessary modications to CTF so that it can execute these new models. Specically, this means implementing an outer-iteration loop, specic to BWR models, that equalizes the pressure loss over all assemblies in the core (which are not connected due to the channel boxes) by adjusting inlet mass ow rate. A third stage involves assessing the standard convergence metrics that are used by CTF to determine when a simulation is steady-state. The nal stage has resulted in the implementation of new metrics in the code that give a better indication of how steady the solution is at convergence. This report summarizes these eorts and provides a demonstration of CTF's BWR-modeling capabilities. CASL-U-2016-1030-000

  9. Cell Locating with the Image Analysis System of the CAS-LIBB Single-Particle Microbeam Facility

    Institute of Scientific and Technical Information of China (English)

    Wang Xiaohua; Wang Shaohu; Yu Zengliang

    2005-01-01

    A single-particle microbeam facility has been constructed at the Key Laboratory of Ion Beam Bioengineering (LIBB), Chinese Academy of Sciences (CAS). At the CAS-LIBB microbeam facility, we have developed protocols to place exact numbers of charged particles through nuclear centroids of cells, at defined positions in the cytoplasm relative to the nucleus, and through defined fractions of cells in a population. In this paper, we address the methods for nucleus, cytoplasm and bystander (either a single or an exact number of ions is delivered to a certain percentage of cells in a population to study the bystander effects of radiation) irradiation in detail from the precision of target finding and cell locating in the image analysis system. Moreover, for cells touching slightly in an image, a watershed method is used to separate these touching objects;after that, the number of objects in an image is counted accurately and the irradiation points are located precisely.

  10. Sports Facilities, Shopping Centers or Homes: What Locations are Important for Adults’ Physical Activity? A Cross-Sectional Study

    Directory of Open Access Journals (Sweden)

    Marijke Jansen

    2016-03-01

    Full Text Available Physical activity (PA is influenced by the built environment. However, little is known about the types of built environment where adults spend their time, and at what levels of PA they engage in those environments. Understanding the effect of the built environment on PA requires insight into PA behavior at different types of locations (e.g., home, work, shopping centers, and sports facilities. Therefore, this study describes where adults aged 45–65 years were active with moderate-to-vigorous intensity (MVPA, and examines associations of socio-demographic factors and neighborhood with MVPA at these locations. Participants’ (N = 308 PA was measured for seven days using accelerometers and GPS-devices. Adults spent most minutes of MVPA at home and work. Highest MVPA-ratios of total time spent at a location were achieved in sports facilities and during transport. Neighborhood characteristics and socio-demographic factors such as work status, health status and household structure, had significant effects on MVPA at various locations and on total MVPA. Understanding PA behavior at various locations may provide insights that allow professionals in different domains (e.g., health, landscaping, urban planning to develop strategies to stimulate PA.

  11. Sports Facilities, Shopping Centers or Homes: What Locations are Important for Adults' Physical Activity? A Cross-Sectional Study.

    Science.gov (United States)

    Jansen, Marijke; Ettema, Dick; Pierik, Frank; Dijst, Martin

    2016-03-04

    Physical activity (PA) is influenced by the built environment. However, little is known about the types of built environment where adults spend their time, and at what levels of PA they engage in those environments. Understanding the effect of the built environment on PA requires insight into PA behavior at different types of locations (e.g., home, work, shopping centers, and sports facilities). Therefore, this study describes where adults aged 45-65 years were active with moderate-to-vigorous intensity (MVPA), and examines associations of socio-demographic factors and neighborhood with MVPA at these locations. Participants' (N = 308) PA was measured for seven days using accelerometers and GPS-devices. Adults spent most minutes of MVPA at home and work. Highest MVPA-ratios of total time spent at a location were achieved in sports facilities and during transport. Neighborhood characteristics and socio-demographic factors such as work status, health status and household structure, had significant effects on MVPA at various locations and on total MVPA. Understanding PA behavior at various locations may provide insights that allow professionals in different domains (e.g., health, landscaping, urban planning) to develop strategies to stimulate PA.

  12. Department of Energy’s ARM Climate Research Facility External Data Center Operations Plan Located At Brookhaven National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Cialella, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Gregory, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Lazar, K. [Brookhaven National Lab. (BNL), Upton, NY (United States); Liang, M. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ma, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Tilp, A. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wagener, R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2015-05-01

    The External Data Center (XDC) Operations Plan describes the activities performed to manage the XDC, located at Brookhaven National Laboratory (BNL), for the Department of Energy’s Atmospheric Radiation Measurement (ARM) Climate Research Facility. It includes all ARM infrastructure activities performed by the Data Management and Software Engineering Group (DMSE) at BNL. This plan establishes a baseline of expectation within the ARM Operations Management for the group managing the XDC.

  13. Smart facility location planning for Smart Cities: using GIS technology and facility provision standards for pro-active planning of social facilities to support smart growth

    CSIR Research Space (South Africa)

    Green, Chéri

    2016-08-01

    Full Text Available This paper describes a rational approach to the planning of social facility provision to eradicate service backlogs of the current period as well as preparing for the future. For more than a decade a GIS based methodology has been used in South...

  14. 76 FR 60390 - Irradiation Treatment; Location of Facilities in the Southern United States

    Science.gov (United States)

    2011-09-29

    ... for the irradiation treatment of certain imported fruit from India and Thailand upon arrival in the..., and to enforce the provisions of the customs and navigation laws in force. \\3\\ Commuting area would be... over nuclear facilities and materials. Irradiation of Fruits From India and Thailand Currently, the...

  15. An Integrated Assessment of Location-Dependent Scaling for Microalgae Biofuel Production Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Andre M.; Abodeely, Jared; Skaggs, Richard; Moeglein, William AM; Newby, Deborah T.; Venteris, Erik R.; Wigmosta, Mark S.

    2014-07-01

    Successful development of a large-scale microalgae-based biofuels industry requires comprehensive analysis and understanding of the feedstock supply chain—from facility siting/design through processing/upgrading of the feedstock to a fuel product. The evolution from pilot-scale production facilities to energy-scale operations presents many multi-disciplinary challenges, including a sustainable supply of water and nutrients, operational and infrastructure logistics, and economic competitiveness with petroleum-based fuels. These challenges are addressed in part by applying the Integrated Assessment Framework (IAF)—an integrated multi-scale modeling, analysis, and data management suite—to address key issues in developing and operating an open-pond facility by analyzing how variability and uncertainty in space and time affect algal feedstock production rates, and determining the site-specific “optimum” facility scale to minimize capital and operational expenses. This approach explicitly and systematically assesses the interdependence of biofuel production potential, associated resource requirements, and production system design trade-offs. The IAF was applied to a set of sites previously identified as having the potential to cumulatively produce 5 billion-gallons/year in the southeastern U.S. and results indicate costs can be reduced by selecting the most effective processing technology pathway and scaling downstream processing capabilities to fit site-specific growing conditions, available resources, and algal strains.

  16. MRS/IS facility co-located with a repository: preconceptual design and life-cycle cost estimates

    Energy Technology Data Exchange (ETDEWEB)

    Smith, R.I.; Nesbitt, J.F.

    1982-11-01

    A program is described to examine the various alternatives for monitored retrievable storage (MRS) and interim storage (IS) of spent nuclear fuel, solidified high-level waste (HLW), and transuranic (TRU) waste until appropriate geologic repository/repositories are available. The objectives of this study are: (1) to develop a preconceptual design for an MRS/IS facility that would become the principal surface facility for a deep geologic repository when the repository is opened, (2) to examine various issues such as transportation of wastes, licensing of the facility, and environmental concerns associated with operation of such a facility, and (3) to estimate the life cycle costs of the facility when operated in response to a set of scenarios which define the quantities and types of waste requiring storage in specific time periods, which generally span the years from 1990 until 2016. The life cycle costs estimated in this study include: the capital expenditures for structures, casks and/or drywells, storage areas and pads, and transfer equipment; the cost of staff labor, supplies, and services; and the incremental cost of transporting the waste materials from the site of origin to the MRS/IS facility. Three scenarios are examined to develop estimates of life cycle costs of the MRS/IS facility. In the first scenario, HLW canisters are stored, starting in 1990, until the co-located repository is opened in the year 1998. Additional reprocessing plants and repositories are placed in service at various intervals. In the second scenario, spent fuel is stored, starting in 1990, because the reprocessing plants are delayed in starting operations by 10 years, but no HLW is stored because the repositories open on schedule. In the third scenario, HLW is stored, starting in 1990, because the repositories are delayed 10 years, but the reprocessing plants open on schedule.

  17. Innovative Solid State Lighting Replacements for Industrial and Test Facility Locations Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed effort will develop a solid-state LED replacement lamp for rocket engine test stand lighting and more general hazardous-location lighting. The LED...

  18. Supporting Education... Building Canada: Child Poverty and Schools. Background Material for Parliamentarians and Staff. CTF Hill Day 2009

    Science.gov (United States)

    Canadian Teachers' Federation (NJ1), 2009

    2009-01-01

    The Canadian Teachers' Federation (CTF) is an active member of various coalitions and networks working to enhance the well-being of Canadian children and youth, including the National Alliance for Children and Youth and Campaign 2000. Among CTF's priorities is to support teachers and teachers' organizations as strong advocates for social justice,…

  19. 基于失效情景的应急设施选址问题%Emergency Facility Location Problem Based on the Facility Failure Scenarios

    Institute of Scientific and Technical Information of China (English)

    张敏; 黄钧; 朱建明

    2012-01-01

    非常规突发事件巨大的破坏力以及发生时间、地点和规模的不确定性,使应急系统内设施有可能被破坏而失效,因此选址时必须考虑设施失效情景的发生.给出以最大限度覆盖用户需求为目标,基于失效设施数目具有不确定性情景的设施选址双层随机规划模型;通过计算模型上下界,给出减小规模的等价模型,降低了双层规划求解难度;最后实验验证了模型的合理性,并给出新增选址方案.%The facility in the emergency system is possible to be out of work because of the huge destructive power of the irregular emergency and the uncertainty of the time, place and scale of occurrence, so facility failure scenarios must be considered at the time of location. In this paper, the bi-level stochastic programming location model is proposed which target is covering the demand of the customers maximally on the basis of defining the facility uncertain failure scenarios. The equivalence model with reducing scale is given through calculating the upper bound and lower bound of the model and the difficulty for solving the bi-level stochastic programming model is lowered. Lastly, the rationality of the model is proved by the test and the new additional location scheme is given.

  20. Facility Location Using Maximum Covering Model: An Application In Retail Sector

    Directory of Open Access Journals (Sweden)

    Çiğdem Alabaş Uslu

    2012-06-01

    Full Text Available In this study, a store location problem has been addressed for service sector, and a real application problem for a leading firm in modern retail sector in Turkey has been solved by modeling with mathematical programming. Since imitating a store location in retail sector is hard and provides an important competitive edge, determining accurate store locations becomes a critical issue for the management. Application problem solved in this study is to choose appropriate areas for opening stores with different capacities and quantities in Umraniye, Istanbul. The problem has been converted to a maximum set covering model by considering after sales forecasts and also by taking into account several decision criteria foreseen by the management. Optimum solutions of the developed model for different scenarios has been obtained using a package program and presented to the firm management.

  1. CTF3 Probe Beam LINAC Commissioning and Operations

    CERN Document Server

    Farabolini, W; Curtoni, A; Girardot, P; Peauger, F; Simon, C S; Chevallay, E; Divall Csatari, M; Lebas, N; Petrarca, M; Palaia, A; Ruber, R J M Y; Ziemann, V G

    2010-01-01

    The probe beam LINAC, CAL­IFES, of the CLIC Test Fa­cil­i­ty (CTF3) has been de­vel­oped by CEA Saclay, LAL Orsay and CERN to de­liv­er trains of short bunch­es (0.75 ps) spaced by 0.666 ps at an en­er­gy around 170 MeV with a charge of 0.6 nC to the TBTS (Two-beam Test Stand) in­tend­ed to test the high gra­di­ent CLIC ac­cel­er­at­ing struc­tures. Based on 3 for­mer LIL ac­cel­er­at­ing struc­tures and on a newly de­vel­oped RF pho­to-in­jec­tor, the whole ac­cel­er­a­tor is pow­ered with a sin­gle 3 GHz klystron de­liv­er­ing puls­es of 45 MW through a RF pulse com­pres­sion cav­i­ty and a net­work of waveg­uides, split­ters, phase-shifters and an at­ten­u­a­tor. We re­late here re­sults col­lect­ed dur­ing the var­i­ous com­mis­sion­ing and op­er­a­tion pe­ri­ods which led to nom­i­nal per­for­mances and sta­ble beam char­ac­ter­is­tics de­liv­ered to the TBTS. Progress has been made in the laser sys­tem for beam charge and sta...

  2. Multi-dimensional boron transport modeling in subchannel approach: Part II. Validation of CTF boron tracking model and adding boron precipitation model

    Energy Technology Data Exchange (ETDEWEB)

    Ozdemir, Ozkan Emre, E-mail: ozdemir@psu.edu; Avramova, Maria N., E-mail: mna109@psu.edu

    2014-10-15

    Highlights: • Validation of implemented multi-dimensional subchannel boron transport model. • Extension of boron transport model to entrained droplets. • Implementation of boron precipitation model. • Testing of the boron precipitation model under transient condition. - Abstract: The risk of small-break loss of coolant accident (SB-LOCA) and other reactivity initiated transients caused by boron dilution in the light water reactors (LWRs), and the complications of tracking the soluble boron concentration experimentally inside the primary coolant have stimulated the interest in computational studies for accurate boron tracking simulations in nuclear reactors. In Part I of this study, the development and implementation of a multi-dimensional boron transport model with modified Godunov scheme based on a subchannel approach within the COBRA-TF (CTF) thermal-hydraulic code was presented. The modified Godunov scheme approach with a physical diffusion term was determined to provide the most accurate and precise solution. Current paper extends these conclusions and presents the model validation studies against experimental data from the Rossendorf coolant mixing model (ROCOM) test facility. In addition, the importance of the two-phase flow characteristics in modeling boron transient are emphasized, especially during long-term cooling period after the loss of coolant accident (LOCA) condition in pressurized water reactors (PWRs). The CTF capabilities of boron transport modeling are further improved based on the three-field representation of the two-phase flow utilized in the code. The boron transport within entrained droplets is modeled, and a model for predicting the boron precipitation under transient conditions is developed and tested. It is aimed to extend the applicability of CTF to reactor transient simulations, and particularly to a large-break loss of coolant accident (LB-LOCA) analysis.

  3. A Novel Hierarchical Model to Locate Health Care Facilities with Fuzzy Demand Solved by Harmony Search Algorithm

    Directory of Open Access Journals (Sweden)

    Mehdi Alinaghian

    2014-08-01

    Full Text Available In the field of health losses resulting from failure to establish the facilities in a suitable location and the required number, beyond the cost and quality of service will result in an increase in mortality and the spread of diseases. So the facility location models have special importance in this area. In this paper, a successively inclusive hierarchical model for location of health centers in term of the transfer of patients from a lower level to a higher level of health centers has been developed. Since determination the exact number of demand for health care in the future is difficult and in order to make the model close to the real conditions of demand uncertainty, a fuzzy programming model based on credibility theory is considered. To evaluate the proposed model, several numerical examples are solved in small size. In order to solve large scale problems, a meta-heuristic algorithm based on harmony search algorithm was developed in conjunction with the GAMS software which indicants the performance of the proposed algorithm.

  4. Evaluation of the location and recency of faulting near prospective surface facilities in Midway Valley, Nye County, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Swan, F.H.; Wesling, J.R.; Angell, M.M.; Thomas, A.P.; Whitney, J.W.; Gibson, J.D.

    2002-01-17

    Evaluation of surface faulting that may pose a hazard to prospective surface facilities is an important element of the tectonic studies for the potential Yucca Mountain high-level radioactive waste repository in southwestern Nevada. For this purpose, a program of detailed geologic mapping and trenching was done to obtain surface and near-surface geologic data that are essential for determining the location and recency of faults at a prospective surface-facilities site located east of Exile Hill in Midway Valley, near the eastern base of Yucca Mountain. The dominant tectonic features in the Midway Valley area are the north- to northeast-trending, west-dipping normal faults that bound the Midway Valley structural block-the Bow Ridge fault on the west side of Exile Hill and the Paint-brush Canyon fault on the east side of the valley. Trenching of Quaternary sediments has exposed evidence of displacements, which demonstrate that these block-bounding faults repeatedly ruptured the surface during the middle to late Quaternary. Geologic mapping, subsurface borehole and geophysical data, and the results of trenching activities indicate the presence of north- to northeast-trending faults and northwest-trending faults in Tertiary volcanic rocks beneath alluvial and colluvial sediments near the prospective surface-facilities site. North to northeast-trending faults include the Exile Hill fault along the eastern base of Exile Hill and faults to the east beneath the surficial deposits of Midway Valley. These faults have no geomorphic expression, but two north- to northeast-trending zones of fractures exposed in excavated profiles of middle to late Pleistocene deposits at the prospective surface-facilities site appear to be associated with these faults. Northwest-trending faults include the West Portal and East Portal faults, but no disruption of Quaternary deposits by these faults is evident. The western zone of fractures is associated with the Exile Hill fault. The eastern

  5. Evaluation of the Location and Recency of Faulting Near Prospective Surface Facilities in Midway Valley, Nye County, Nevada

    Science.gov (United States)

    Swan, F.H.; Wesling, J.R.; Angell, M.M.; Thomas, A.P.; Whitney, J.W.; Gibson, J.D.

    2001-01-01

    Evaluation of surface faulting that may pose a hazard to prospective surface facilities is an important element of the tectonic studies for the potential Yucca Mountain high-level radioactive waste repository in southwestern Nevada. For this purpose, a program of detailed geologic mapping and trenching was done to obtain surface and near-surface geologic data that are essential for determining the location and recency of faults at a prospective surface-facilities site located east of Exile Hill in Midway Valley, near the eastern base of Yucca Mountain. The dominant tectonic features in the Midway Valley area are the north- to northeast-trending, west-dipping normal faults that bound the Midway Valley structural block-the Bow Ridge fault on the west side of Exile Hill and the Paint-brush Canyon fault on the east side of the valley. Trenching of Quaternary sediments has exposed evidence of displacements, which demonstrate that these block-bounding faults repeatedly ruptured the surface during the middle to late Quaternary. Geologic mapping, subsurface borehole and geophysical data, and the results of trenching activities indicate the presence of north- to northeast-trending faults and northwest-trending faults in Tertiary volcanic rocks beneath alluvial and colluvial sediments near the prospective surface-facilities site. North to northeast-trending faults include the Exile Hill fault along the eastern base of Exile Hill and faults to the east beneath the surficial deposits of Midway Valley. These faults have no geomorphic expression, but two north- to northeast-trending zones of fractures exposed in excavated profiles of middle to late Pleistocene deposits at the prospective surface-facilities site appear to be associated with these faults. Northwest-trending faults include the West Portal and East Portal faults, but no disruption of Quaternary deposits by these faults is evident. The western zone of fractures is associated with the Exile Hill fault. The eastern

  6. Mechanical Link between Cohesion Establishment and DNA Replication: Ctf7p/Eco1p, a Cohesion Establishment Factor, Associates with Three Different Replication Factor C Complexes

    OpenAIRE

    Kenna, Margaret A.; Skibbens, Robert V.

    2003-01-01

    CTF7/ECO1 is an essential yeast gene required for the establishment of sister chromatid cohesion. The findings that CTF7/ECO1, POL30 (PCNA), and CHL12/CTF18 (a replication factor C [RFC] homolog) genetically interact provided the first evidence that the processes of cohesion establishment and DNA replication are intimately coupled—a link now confirmed by other studies. To date, however, it is unknown how Ctf7p/Eco1p function is coupled to DNA replication or whether Ctf7p/Eco1p physically asso...

  7. A simplified dynamic model for existing buildings using CTF and thermal network models

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Xinhua; Wang, Shengwei [Department of Building Services Engineering, The Hong Kong Polytechnic University (China)

    2008-09-15

    An alternative simplified building model is developed to describe existing building system aiming at providing performance benchmark for performance evaluation and diagnosis at building level and performance prediction for air-conditioning system optimal control. This model combines detailed physical models of building envelopes and a thermal network model of building internal mass. The detailed physical models are the CTF (Conduction Transfer Function) models of building envelopes based on the easily available detailed physical properties of exterior walls and roof. The thermal network model is the 2R2C model, and its parameters are estimated and optimized using genetic algorithm with short-term monitored operation data. The parameter optimization of the simplified building internal mass model (2R2C) and the simplified dynamic building model (i.e., CTF+2R2C model) are validated in a high-rising commercial office building under various weather conditions. This CTF+2R2C model is an alternative modeling approach for simulating the overall building dynamic thermal performance when CTF model is chosen to model the building envelope. (author)

  8. Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.

    Directory of Open Access Journals (Sweden)

    Stefan Z Lutz

    Full Text Available AIMS/HYPOTHESIS: Recently, cardiotrophin-1, a member of the interleukin-6 family of cytokines was described to protect beta-cells from apoptosis, to improve glucose-stimulated insulin secretion and insulin resistance, and to prevent streptozotocin-induced diabetes in mice. Here, we studied whether common single nucleotide polymorphisms (SNPs in the CTF1 locus, encoding cardiotrophin-1, influence insulin secretion and insulin sensitivity in humans. METHODS: We genotyped 1,771 German subjects for three CTF1 tagging SNPs (rs1046276, rs1458201, and rs8046707. The subjects were metabolically characterized by an oral glucose tolerance test. Subgroups underwent magnetic resonance (MR imaging/spectroscopy and hyperinsulinaemic-euglycaemic clamps. RESULTS: After appropriate adjustment, the minor allele of CTF1 SNP rs8046707 was significantly associated with decreased in vivo measures of insulin sensitivity. The other tested SNPs were not associated with OGTT-derived sensitivity parameters, nor did the three tested SNPs show any association with OGTT-derived parameters of insulin release. In the MR subgroup, SNP rs8046707 was nominally associated with lower visceral adipose tissue. Furthermore, the SNP rs1458201 showed a nominal association with increased VLDL levels. CONCLUSIONS: In conclusion, this study, even though preliminary and awaiting further confirmation by independent replication, provides first evidence that common genetic variation in CTF1 could contribute to insulin sensitivity in humans. Our SNP data indicate an insulin-desensitizing effect of cardiotrophin-1 and underline that cardiotrophin-1 represents an interesting target to influence insulin sensitivity.

  9. GIS and Optimisation: Potential Benefits for Emergency Facility Location in Humanitarian Logistics

    Directory of Open Access Journals (Sweden)

    Oscar Rodríguez-Espíndola

    2016-03-01

    Full Text Available Floods are one of the most dangerous and common disasters worldwide, and these disasters are closely linked to the geography of the affected area. As a result, several papers in the academic field of humanitarian logistics have incorporated the use of Geographical Information Systems (GIS for disaster management. However, most of the contributions in the literature are using these systems for network analysis and display, with just a few papers exploiting the capabilities of GIS to improve planning and preparedness. To show the capabilities of GIS for disaster management, this paper uses raster GIS to analyse potential flooding scenarios and provide input to an optimisation model. The combination is applied to two real-world floods in Mexico to evaluate the value of incorporating GIS for disaster planning. The results provide evidence that including GIS analysis for a decision-making tool in disaster management can improve the outcome of disaster operations by reducing the number of facilities used at risk of flooding. Empirical results imply the importance of the integration of advanced remote sensing images and GIS for future systems in humanitarian logistics.

  10. Optimal Facility Location Model Based on Genetic Simulated Annealing Algorithm for Siting Urban Refueling Stations

    Directory of Open Access Journals (Sweden)

    Dawei Chen

    2015-01-01

    Full Text Available This paper analyzes the impact factors and principles of siting urban refueling stations and proposes a three-stage method. The main objective of the method is to minimize refueling vehicles’ detour time. The first stage aims at identifying the most frequently traveled road segments for siting refueling stations. The second stage focuses on adding additional refueling stations to serve vehicles whose demands are not directly satisfied by the refueling stations identified in the first stage. The last stage further adjusts and optimizes the refueling station plan generated by the first two stages. A genetic simulated annealing algorithm is proposed to solve the optimization problem in the second stage and the results are compared to those from the genetic algorithm. A case study is also conducted to demonstrate the effectiveness of the proposed method and algorithm. The results indicate the proposed method can provide practical and effective solutions that help planners and government agencies make informed refueling station location decisions.

  11. Location, Location, Location

    CERN Multimedia

    Clery, Daniel

    2007-01-01

    "When nations vie for massive international scientific facilities, science can take a back seat to politics and even sheer chance. Dealmakers say there's no magic formula for getting things right." (3 pages)

  12. Location, location, location

    CERN Multimedia

    Clery, Daniel

    2007-01-01

    "When nations vie for massive international scientific facilities, science can take a back seat to politics and even sheer chance. Dealmakers say there's no magic formula for getting things right." (4,5 pages)

  13. Prisons and Correctional Facilities, Located during MicroData field address collection 2004-2006. Kept in Spillman database for retrieval., Published in 2004, Vilas County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Prisons and Correctional Facilities dataset current as of 2004. Located during MicroData field address collection 2004-2006. Kept in Spillman database for retrieval..

  14. Tire Processing Facilities, Location of motor vehicle inspection sites within Louisiana, Published in 2005, 1:24000 (1in=2000ft) scale, Louisiana State University.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Tire Processing Facilities dataset, published at 1:24000 (1in=2000ft) scale as of 2005. It is described as 'Location of motor vehicle inspection sites within...

  15. Executive Order 12898 and Social, Economic, and Sociopolitical Factors Influencing Toxic Release Inventory Facility Location in EPA Region 6: A Multi-Scale Spatial Assessment of Environmental Justice

    Science.gov (United States)

    Moore, Andrea Lisa

    2013-01-01

    Toxic Release Inventory facilities are among the many environmental hazards shown to create environmental inequities in the United States. This project examined four factors associated with Toxic Release Inventory, specifically, manufacturing facility location at multiple spatial scales using spatial analysis techniques (i.e., O-ring statistic and…

  16. Executive Order 12898 and Social, Economic, and Sociopolitical Factors Influencing Toxic Release Inventory Facility Location in EPA Region 6: A Multi-Scale Spatial Assessment of Environmental Justice

    Science.gov (United States)

    Moore, Andrea Lisa

    2013-01-01

    Toxic Release Inventory facilities are among the many environmental hazards shown to create environmental inequities in the United States. This project examined four factors associated with Toxic Release Inventory, specifically, manufacturing facility location at multiple spatial scales using spatial analysis techniques (i.e., O-ring statistic and…

  17. BAF Complex Is Closely Related to and Interacts with NF1/CTF and RNA Polymerase Ⅱ in Gene Transcriptional Activation

    Institute of Scientific and Technical Information of China (English)

    Li-Hui ZHAO; Xue-Qing BA; Xiao-Guang WANG; Xiao-Juan ZHU; Li WANG; Xian-Lu ZENG

    2005-01-01

    Brg- or hBrm-associated factor (BAF) complexes, a chromatin-remodeling complex family of mammalian cells, facilitate transcriptional activity by remodeling nucleosome structure. Brg 1 is the core subunit of Brg-associated factor complexes. In the present study, we investigated the spatial relationship between Brg1 and nuclear factor 1 (NF1/CTF) and RNA polymerase Ⅱ (RNAP Ⅱ) upon gene transcriptional activation in vivo by employing immuno-gold labeling. The data showed that Brg1 was closely co-localized with NF1/CTF and RNAP Ⅱ in HeLa cells. Moreover, the co-immunoprecipitation assay further revealed that Brg1 can be isolated together with NF1/CTF and RNAP Ⅱ in the ConA-stimulated, but not the resting,T lymphocyte. The combined results suggested that BAF complexes can interact with NF1/CTF and RNAP Ⅱ, and this interaction is closely dependent on the activation of gene transcription.

  18. Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae.

    Science.gov (United States)

    Mehta, Gunjan D; Agarwal, Meenakshi; Ghosh, Santanu K

    2014-03-01

    Meiosis is a specialized cell division process through which chromosome numbers are reduced by half for the generation of gametes. Kinetochore, a multiprotein complex that connects centromeres to microtubules, plays essential role in chromosome segregation. Ctf19 is the key central kinetochore protein that recruits all the other non-essential proteins of the Ctf19 complex in budding yeast. Earlier studies have shown the role of Ctf19 complex in enrichment of cohesin around the centromeres both during mitosis and meiosis, leading to sister chromatid cohesion and meiosis II disjunction. Here we show that Ctf19 is also essential for the proper execution of the meiosis I specific unique events, such as non-homologous centromere coupling, homologue pairing, chiasmata resolution and proper orientation of homologues and sister chromatids with respect to the spindle poles. Additionally, this investigation reveals that proper kinetochore function is required for faithful chromosome condensation in meiosis. Finally, this study suggests that absence of Ctf19 affects the integrity of meiotic kinetochore differently than that of the mitotic kinetochore. Consequently, absence of Ctf19 leads to gross chromosome missegregation during meiosis as compared with mitosis. Hence, this study reports for the first time the differential impact of a non-essential kinetochore protein on the mitotic and meiotic kinetochore ensembles and hence chromosome segregation. © 2014 John Wiley & Sons Ltd.

  19. A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 of TDP-43 depends on the proteasome.

    Science.gov (United States)

    Liu, Y; Duan, W; Guo, Y; Li, Z; Han, H; Zhang, S; Yuan, P; Li, C

    2014-12-05

    The C-terminal fragments-25(CTF25) of TDP-43 is a fragment of TAR DNA-binding protein 43kDa (TDP-43), which is involved in RNA metabolism, neurite outgrowth, and neuronal development and stress granules. Not until recently did evidence suggest that CTF25 might play an important role in amyotrophic lateral sclerosis (ALS) pathogenesis. However, mechanical details on CTF25 causing motor neuron degeneration still remain unknown. To study the toxicity of CTF25 of TDP-43, we established a cellular model stably expressing CTF25 of TDP-43. Herein, we found that stably expressed CTF25 could induce significant oxidative stress and was mainly degraded by the proteasome pathway in cells. Furthermore, the neurotoxicity of CTF25 of TDP-43 was dependent on proteasome activity. In addition, electron microscopy showed mitochondrial swelling and cristae dilation in cells expressing CTF25 and that CTF25 aggregates were characterized by filamentous bundles and electron dense granular material. In conclusion, the new cellular model mimics classical toxic TDP-43 cellular model and interestingly the toxicity of CTF25 is dependent on the proteasome.

  20. The Ctf18RFC clamp loader is essential for telomere stability in telomerase-negative and mre11 mutant alleles.

    Directory of Open Access Journals (Sweden)

    Honghai Gao

    Full Text Available The function of the replication clamp loaders in the semi-conservative telomere replication and their relationship to telomerase- and recombination mechanisms of telomere addition remains ambiguous. We have investigated the variant clamp loader Ctf18 RFC (Replication Factor C. To understand the role of Ctf18 at the telomere, we first investigated genetic interactions after loss of Ctf18 and TLC1 (the yeast telomerase RNA. We find that the tlc1Δ ctf18Δ double mutant confers a rapid >1000-fold decrease in viability. The rate of loss was similar to the kinetics of cell death in rad52Δ tlc1Δ cells. However, the Ctf18 pathway is distinct from Rad52, required for the repair of DSBs, as demonstrated by the synthetic lethality of rad52▵ tlc1Δ ctf18Δ triple mutants. These data suggest that each mutant elicits non-redundant defects acting on the same substrate. Second, interactions of the yeast hyper-recombinational mutant, mre11A470T, with ctf18▵ confer a synergistic cold sensitivity. The phenotype of these double mutants ultimately results in telomere loss and the generation of recombinational survivors. We observed a similar synergism between single mutants that led to hypersensitivity to the DNA alkylating agent, methane methyl sulphonate (MMS, the replication fork inhibitor hydroxyurea (HU, and to a failure to separate telomeres of sister chromatids. Hence, ctf18Δ and mre11A470T act in different pathways on telomere substrates for multiple phenotypes. The mre11A470T cells also displayed a DNA damage response (DDR at 15°C but not at 30°C while ctf18Δ mutants conferred a constitutive DDR activity. Both the 15°C DDR pattern and growth rate were reversible at 30°C and displayed telomerase activity in vivo. We hypothesize that Ctf18 confers protection against stalling and/or breaks at the replication fork in cells that either lack, or are compromised for, telomerase activity. This Ctf18-based function is likely to contribute another level

  1. High intensity profile monitor for time resolved spectrometry at the CLIC Test Facility 3

    Science.gov (United States)

    Olvegård, M.; Adli, E.; Braun, H. H.; Bravin, E.; Chritin, N.; Corsini, R.; Dabrowski, A. E.; Döbert, S.; Dutriat, C.; Egger, D.; Lefèvre, T.; Mete, O.; Skowronski, P. K.; Tecker, F.

    2012-08-01

    The power source of the Compact LInear Collider (CLIC) relies on the generation and deceleration of a high-intensity electron drive beam. In order to provide the best radio-frequency (RF) to beam-energy transfer efficiency, the electron beam is accelerated using fully loaded RF cavities, which leads to strong beam loading effects resulting in a high-energy transient. The stability of the RF power produced by the drive beam depends on the stability of the drive beam energy and energy spread along the pulse. The control and the monitoring of the time evolution of the beam energy distribution are therefore crucial for the accelerator performance. For this purpose segmented beam dumps, which are simple and robust devices, have been designed and installed at the CLIC Test Facility 3 (CTF3). These devices are located at the end of spectrometer lines and provide horizontal beam profiles with a time resolution better than 10 ns. The segmented dumps are composed of parallel, vertical, metallic plates, and are based on the same principle as a Faraday cup: the impinging beam current is read by a fast acquisition channel. Both FLUKA and Geant4 simulations were performed to define the optimum detector geometry for beam energies ranging from 5 MeV to 150 MeV. This paper presents a detailed description of the different steps of the design: the optimization of the detector spatial resolution, the minimization of the thermal load and the long-term damage resulting from high radiation doses. Four segmented dumps are currently used in the CTF3 complex. Their measured performance and limitations are presented in this paper. Typical beam spectra as measured in the CTF3 linac are also presented along with a description of the RF manipulations needed for tuning the beam energy spectrum.

  2. Solving the competitive facility location problem considering the reactions of competitor with a hybrid algorithm including Tabu Search and exact method

    Science.gov (United States)

    Bagherinejad, Jafar; Niknam, Azar

    2017-06-01

    In this paper, a leader-follower competitive facility location problem considering the reactions of the competitors is studied. A model for locating new facilities and determining levels of quality for the facilities of the leader firm is proposed. Moreover, changes in the location and quality of existing facilities in a competitive market where a competitor offers the same goods or services are taken into account. The competitor could react by opening new facilities, closing existing ones, and adjusting the quality levels of its existing facilities. The market share, captured by each facility, depends on its distance to customer and its quality that is calculated based on the probabilistic Huff's model. Each firm aims to maximize its profit subject to constraints on quality levels and budget of setting up new facilities. This problem is formulated as a bi-level mixed integer non-linear model. The model is solved using a combination of Tabu Search with an exact method. The performance of the proposed algorithm is compared with an upper bound that is achieved by applying Karush-Kuhn-Tucker conditions. Computational results show that our algorithm finds near the upper bound solutions in a reasonable time.

  3. The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time.

    Science.gov (United States)

    Hiraga, Shin-ichiro; Robertson, E Douglas; Donaldson, Anne D

    2006-04-05

    Chromosome ends in Saccharomyces cerevisiae are positioned in clusters at the nuclear rim. We report that Ctf18, Ctf8, and Dcc1, the subunits of a Replication Factor C (RFC)-like complex, are essential for the perinuclear positioning of telomeres. In both yeast and mammalian cells, peripheral nuclear positioning of chromatin during G1 phase correlates with late DNA replication. We find that the mislocalized telomeres of ctf18 cells still replicate late, showing that late DNA replication does not require peripheral positioning during G1. The Ku and Sir complexes have been shown to act through separate pathways to position telomeres, but in the absence of Ctf18 neither pathway can act fully to maintain telomere position. Surprisingly CTF18 is not required for Ku or Sir4-mediated peripheral tethering of a nontelomeric chromosome locus. Our results suggest that the Ctf18 RFC-like complex modifies telomeric chromatin to make it competent for normal localization to the nuclear periphery.

  4. 层次型应急设施布局模型及其应用%Hierarchical Emergency Facility Location Model and Its Application

    Institute of Scientific and Technical Information of China (English)

    王铮; 廖悲雨; 隋文娟

    2011-01-01

    应急设施的特殊性决定了应急设施布局作为特殊的设施布局问题,必须更加注重及时性。应急服务的级别决定应急布局模型的考虑因素,现实中往往同时布局多个层次的应急设施,本文基于一个P-中心重心的混合模型,建立了层次型应急设施布局模型。根据应急服务的真实情况,该模型对距离的测算进行了改进,以交通网络距离代替欧氏距离。最后,将其应用于上海市上海某区的医疗设施布局。%The particularity of emergency facilities determines that emergency facility location, as a special type of facility location problem, must pay more attention to timeliness. According to the levels of emergency services, different factors are taken into account when modeling emergency facility location. Actually, there are often several levels of emergency facilities in our real life. This article proposes a hierarchical emergency facility location model based on a hybrid model of p -center and p -median model, in which a p - center model is applied to the lower level services and a p -median model is applied to the higher level services. In accordance with the real situation of emergency services, this model improves the distance measurement by replacing the Euclidean distance with transport network distance. Finally, the hierarchical emergency facility location model is applied to the medical facilities location in Putuo District of Shanghai.

  5. Development and Implementation of CFD-Informed Models for the Advanced Subchannel Code CTF

    Energy Technology Data Exchange (ETDEWEB)

    Blyth, Taylor S. [Pennsylvania State Univ., University Park, PA (United States); Avramova, Maria [North Carolina State Univ., Raleigh, NC (United States)

    2017-04-01

    The research described in this PhD thesis contributes to the development of efficient methods for utilization of high-fidelity models and codes to inform low-fidelity models and codes in the area of nuclear reactor core thermal-hydraulics. The objective is to increase the accuracy of predictions of quantities of interests using high-fidelity CFD models while preserving the efficiency of low-fidelity subchannel core calculations. An original methodology named Physics- based Approach for High-to-Low Model Information has been further developed and tested. The overall physical phenomena and corresponding localized effects, which are introduced by the presence of spacer grids in light water reactor (LWR) cores, are dissected in corresponding four building basic processes, and corresponding models are informed using high-fidelity CFD codes. These models are a spacer grid-directed cross-flow model, a grid-enhanced turbulent mixing model, a heat transfer enhancement model, and a spacer grid pressure loss model. The localized CFD-models are developed and tested using the CFD code STAR-CCM+, and the corresponding global model development and testing in sub-channel formulation is performed in the thermal- hydraulic subchannel code CTF. The improved CTF simulations utilize data-files derived from CFD STAR-CCM+ simulation results covering the spacer grid design desired for inclusion in the CTF calculation. The current implementation of these models is examined and possibilities for improvement and further development are suggested. The validation experimental database is extended by including the OECD/NRC PSBT benchmark data. The outcome is an enhanced accuracy of CTF predictions while preserving the computational efficiency of a low-fidelity subchannel code.

  6. High-fidelity multiphysics simulation of BWR assembly with coupled TORT-TD/CTF

    Energy Technology Data Exchange (ETDEWEB)

    Magedanz, J. [Dept. of Mechanical and Nuclear Engineering, Pennsylvania State Univ., Reber Building, Univ. Park, PA 16802 (United States); Perin, Y. [Gesellschaft fuer Anlagen- und Reaktorsicherheit GRS mbH, Forschungsinstitute, D-85748 Garching (Germany); Avramova, M. [Dept. of Mechanical and Nuclear Engineering, Pennsylvania State Univ., Reber Building, Univ. Park, PA 16802 (United States); Pautz, A.; Puente-Espel, F.; Seubert, A.; Sureda, A.; Velkov, K.; Zwermann, W. [Gesellschaft fuer Anlagen- und Reaktorsicherheit GRS mbH, Forschungsinstitute, D-85748 Garching (Germany)

    2012-07-01

    This paper describes the application of the coupled codes TORT-TD and CTF to the pin-by-pin modeling of a BWR fuel assembly with thermal-hydraulic feedback. TORT-TD, developed at GRS, is a time-dependent three dimensional discrete ordinates code. CTF is the PSU's improved version of the subchannel code COBRA-TF, which uses a two-fluid, three-field model to represent two-phase flow with entrained droplets, and is commonly applied to evaluate LWR safety margins. The coupled codes system TORT-TD/CTF, already applied to several PWR cases involving MOX, was adapted from PWR to BWR applications. The purpose of the research described in this paper is to verify the coupling for modeling two-phase flow at the pin cell level. Using an ATRIUM-10 assembly, the system's steady-state capabilities were tested on two cases: one without control blade insertion and another with partially inserted blades. The influence of the neutron absorber on local axial and radial parameters is presented. The description of an inlet flow reduction transient is an example for the time-dependent capability of the coupled system. (authors)

  7. Airports and Airfields, Airstrip locations within Sedgwick County. Primary attributes include site number, location ID, facility type, effective date, air strip name, city name, latitude, longitude, and elevation., Published in 2008, 1:1200 (1in=100ft) scale, Sedgwick County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Airports and Airfields dataset current as of 2008. Airstrip locations within Sedgwick County. Primary attributes include site number, location ID, facility type,...

  8. Location, location, location

    NARCIS (Netherlands)

    Anderson, S.P.; Goeree, J.K.; Ramer, R.

    1997-01-01

    We analyze the canonical location-then-price duopoly game with general log- concave consumer densities. A unique pure-strategy equilibrium to the two-stage game exists if the density is not "too asymmetric" and not "too concave." These criteria are satisfied by many commonly used densities. Equilibr

  9. 可变吸引力竞争选址模型与算法研究%Competitive Facility Location Models and Algrithms Based on Variable Attractiveness

    Institute of Scientific and Technical Information of China (English)

    陈中武; 张宗祥

    2013-01-01

    Based on Huff's gravity rule,we consider the competitive facility location problem in which new facilities have to be located by a new market entrant firm to compete against already existing facilities that may belong to one or more competitors.We assume that the probability of customers patronize a facility is proportional to the facility attractiveness and inversely proportional to the distance between them.The objective is to determine the locations of the new facilities and their attractiveness levels so as to maximize the profit.We formulate a mixed-integer nonlinear programming model and try to.Numerical experiments on randomly generated instances demonstrate the effectiveness of the method%结合Huff重力模型,考虑了市场存在一个或多个竞争对手情形下的新设施竞争选址模型.假设顾客访问设施的概率与设施吸引力成正比,与设施同需求点的距离成反比.企业通过确定新设施的选址位置和设施的吸引力水平来追求利润最大化.建立了混合整数非线性规划模型并设计算法进行求解.并通过随机算例验证了算法的有效性.

  10. Design of a 3 GHz Accelerator Structure for the CLIC Test Facility (CTF 3) Drive Beam

    CERN Document Server

    Carron, G.; Luong, M.; Millich, A.; Rugo, E.; Syratchev, I.; Thorndahl, L.

    2000-01-01

    For the CLIC two-beam scheme, a high-current, long-pulse drive beam is required for RF power generation. Taking advantage of the 3 GHz klystrons available at the LEP injector once LEP stops, a 180 MeV electron accelerator is being constructed for a nominal beam current of 3.5 A and 1.5 ms pulse length. The high current requires highly effective suppression of dipolar wakes. Two concepts are investigated for the accelerating structure design: the "Tapered Damped Structure" developed for the CLIC main beam, and the "Slotted Iris - Constant Aperture" structure. Both use 4 SiC loads per cell for effective higher-order mode damping. A full-size prototype of the TDS structure has been built and tested successfully at full power. A first prototype of the SICA structure is being built

  11. The effect of location and facility demand on the marginal cost of delivered wood chips from energy crops: A case study of the state of Tennessee

    Energy Technology Data Exchange (ETDEWEB)

    Graham, R.L.; Liu, W.; Downing, M. [Oak Ridge National Lab., TN (United States). Biofuels Feedstock Development Program; Noon, C.; Daly, M. [Univ. of Tennessee, Knoxville, TN (United States). Management Science Program; Moore, A. [Dept. of Trade and Industry, Harwell (United Kingdom). Energy Technology Support Unit

    1995-12-31

    Cost-supply curves for delivered wood chips from short rotation woody crops were calculated for 21 regularly-spaced locations spanning the state of Tennessee. These curves were used to systematically evaluate the combined effects of location and facility demand on wood chip feedstock costs in Tennessee. The cost-supply curves were developed using BRAVO, a GIS-based decision support system which calculates marginal cost of delivering wood chips to a specific location given road network maps and maps of farmgate prices and supplies of woody chips from short rotation energy crops. Marginal costs of delivered chips varied by both facility location in the state and facility demand. Marginal costs were lowest in central Tennessee unless the facility demand was greater than 2.7 million dry Mg per year (3 million dry tons per year) in which case west Tennessee was the lowest cost region. Marginal costs rose rapidly with increasing facility demand in the mountainous eastern portion of the state. Transportation costs accounted for 18 to 29% of the delivered cost and ranged between $8 and $18/dry Mg ($7 and $16/dry ton). Reducing the expected farmer participation rate from 100% to 50% or 25% dramatically raised the marginal costs of feedstock supply in the east and central regions of the state. The analysis demonstrates the need to use geographically-specific information when projecting the potential costs and supplies of biomass feedstock.

  12. Electro-0ptical Bunch Profile Measurement at CTF3

    CERN Document Server

    Pan, R; Farabolini, W; Goldblatt, A; Lefevre, T; Martyanov, M; Mazzoni, S; Timeo, L; Rey, S; Jamison, S; Gillespie, W; Walsh, D

    2013-01-01

    A new electro-optic bunch profile monitor has recently been installed in CLIC Test Facility 3 at CERN. The monitor is based on an electro-optic spectral decoding scheme which reconstructs the longitudinal profile of the electron bunch by measuring its Coulomb field. The system uses a 780 nm fibre laser system, transported over a 20m long distance to the interaction chamber, where a ZnTe crystal is positioned close to the beam. The assembly also contains a traditional OTR screen, which is coupled to a second optical line and used to adjust the temporal overlap between the laser and the electron pulse. This paper presents the detection system in detail, as well as reporting on the first measurements performed with beam.

  13. 限制设施选址问题的近似算法%Approximation algorithm for limited facility location problem

    Institute of Scientific and Technical Information of China (English)

    刘玉堂; 方奇志

    2013-01-01

    提出了设施选址问题的一个新变体—限制设施选址问题,给出了一个基于随机线性规划舍入的近似算法,并分析了算法的近似度.%The paper presented an approximation algorithm for the Limited Facility Location problem (LFL), which is a new variant of the classical Uncapacitated Facility Location problem(UFL). The algorithm is based on randomized LP rounding, and its approximation ratio was analyzed.

  14. CLIC Test Facility 3

    CERN Multimedia

    Kossyvakis, I; Faus-golfe, A; Nguyen, F

    2007-01-01

    The design of CLIC is based on a two-beam scheme, where short pulses of high power 30 GHz RF are extracted from a drive beam running parallel to the main beam. The 3rd generation CLIC Test Facility (CTF3) will demonstrate the generation of the drive beam with the appropriate time structure, the extraction of 30 GHz RF power from this beam, as well as acceleration of a probe beam with 30 GHz RF cavities. The project makes maximum use of existing equipment and infrastructure of the LPI complex, which became available after the closure of LEP.

  15. Park Facilities, Park Facility point locations within Iredell County, NC, Published in 2009, 1:2400 (1in=200ft) scale, Iredell County GIS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Park Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2009. It is described as 'Park...

  16. Integrating cut-and-solve and semi-Lagrangean based dual ascent for the single-source capacitated facility location problem

    DEFF Research Database (Denmark)

    Gadegaard, Sune Lauth

    This paper describes how the cut-and-solve framework and semi-Lagrangean based dual ascent algorithms can be integrated in two natural ways in order to solve the single source capacitated facility location problem. The first uses the cut-and-solve framework both as a heuristic and as an exact sol...

  17. Branch and bound algorithm for the uncapacitated facility location problem%无容量限制设施选址问题的分支定界法

    Institute of Scientific and Technical Information of China (English)

    李翼; 赵茂先; 李岳佳

    2012-01-01

    设施选址问题是经典的优化问题.一个好的选址方法可以有效节省费用,促进生产和消费的协调与配合,使得设施系统平衡发展.企业的优势和公共设施的盈利能力同样依赖于设施的选址结果.介绍了无容量限制的设施选址问题,给出了该问题的数学模型,提出了解决此问题的一个精确算法———分支定界法,最后通过一个算例说明了算法的有效性.%Facility location problems are classical optimization problems.A good location method can save money efficiently,promote the coordination of production and consumption and obtain the balanced development of facility system.The competitive advantage of firms and the profitability of public facilities depend on the results of these locations.In this paper,uncapacitated facility location problem is introduced.We give a branch and bound method,which is an exact algorithm to solve this problem.Numerical examples illustrate this approach.

  18. Integrating cut-and-solve and semi-Lagrangean based dual ascent for the single-source capacitated facility location problem

    DEFF Research Database (Denmark)

    Gadegaard, Sune Lauth

    This paper describes how the cut-and-solve framework and semi-Lagrangean based dual ascent algorithms can be integrated in two natural ways in order to solve the single source capacitated facility location problem. The first uses the cut-and-solve framework both as a heuristic and as an exact...

  19. Role of Ctf3 and COMA subcomplexes in meiosis: Implication in maintaining Cse4 at the centromere and numeric spindle poles.

    Science.gov (United States)

    Agarwal, Meenakshi; Mehta, Gunjan; Ghosh, Santanu K

    2015-03-01

    During mitosis and meiosis, kinetochore, a conserved multi-protein complex, connects microtubule with the centromere and promotes segregation of the chromosomes. In budding yeast, central kinetochore complex named Ctf19 has been implicated in various functions and is believed to be made up of three biochemically distinct subcomplexes: COMA, Ctf3 and Iml3-Chl4. In this study, we aimed to identify whether Ctf3 and COMA subcomplexes have any unshared function at the kinetochore. Our data suggests that both these subcomplexes may work as a single functional unit without any unique functions, which we tested. Analysis of severity of the defects in the mutants suggests that COMA is epistatic to Ctf3 subcomplex. Interestingly, we noticed that these subcomplexes affect the organization of mitotic and meiotic kinetochores with subtle differences and they promote maintenance of Cse4 at the centromeres specifically during meiosis which is similar to the role of Mis6 (Ctf3 homolog) in fission yeast during mitosis. Interestingly, analysis of ctf3Δ and ctf19Δ mutants revealed a novel role of Ctf19 complex in regulation of SPB cohesion and duplication in meiosis. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. The relationship between the location of pediatric intensive care unit facilities and child death from trauma: a county-level ecologic study.

    Science.gov (United States)

    Odetola, Folafoluwa O; Miller, William C; Davis, Matthew M; Bratton, Susan L

    2005-07-01

    To describe the relationship between the location of Pediatric Intensive Care Unit (PICU) facilities and county-level child death from trauma in the contiguous USA. We conducted a cross-sectional ecologic study using county-level data on death due to trauma in children 0 to 14 years of age from 1996 to 1998. These data were linked to 1997 county-level data on availability of PICU facilities. In 1997, PICU facilities were present in 9% of USA counties. There were 18,337 childhood deaths from trauma in the study period. The presence of PICU facilities in a county was associated with lower mortality from trauma (incidence rate ratio [IRR] = 0.72; 95% CI 0.67-0.78) compared to counties without PICU facilities. After controlling for residence in rural and low-income counties, and the presence of adult medicosurgical intensive care units, the presence of PICU facilities in a county remained associated with lower rates of death from trauma (IRR = 0.82; 95% CI 0.75-0.89). The presence of PICU facilities is related to lower mortality rates due to traumatic injuries at the county level. This finding may reflect the concentration of pediatric subspecialty care in counties with PICUs. This association merits further study with individual-level observations.

  1. Facilities & Leadership

    Data.gov (United States)

    Department of Veterans Affairs — The facilities web service provides VA facility information. The VA facilities locator is a feature that is available across the enterprise, on any webpage, for the...

  2. NIMBY, CLAMP, and the location of new nuclear-related facilities: U.S. national and 11 site-specific surveys.

    Science.gov (United States)

    Greenberg, Michael R

    2009-09-01

    Public and political opposition have made finding locations for new nuclear power plants, waste management, and nuclear research and development facilities a challenge for the U.S. government and the nuclear industry. U.S. government-owned properties that already have nuclear-related activities and commercial nuclear power generating stations are logical locations. Several studies and utility applications to the Nuclear Regulatory Commission suggest that concentrating locations at major plants (CLAMP) has become an implicit siting policy. We surveyed 2,101 people who lived within 50 miles of 11 existing major nuclear sites and 600 who lived elsewhere in the United States. Thirty-four percent favored CLAMP for new nuclear power plants, 52% for waste management facilities, and 50% for new nuclear laboratories. College educated, relatively affluent male whites were the strongest CLAMP supporters. They disproportionately trusted those responsible for the facilities and were not worried about existing nuclear facilities or other local environmental issues. Notably, they were concerned about continuing coal use. Not surprisingly, CLAMP proponents tended to be familiar with their existing local nuclear site. In short, likely CLAMP sites have a large and politically powerful core group to support a CLAMP policy. The challenge to proponents of nuclear technologies will be to sustain this support and expand the base among those who clearly are less connected and receptive to new nearby sites.

  3. First Results from Commissioning of the Phin Photo Injector for CTF3

    CERN Document Server

    Petrarca, M; Chevallay, E; Doebert, S; Elsener, K; Fedosseev, V; Geschonke, G; Losito, R; Masi, A; Mete, O; Rinolfi, L; Dabrowski, A; Divall, M; Champault, N; Bienvenu, G; Jore, M; Mercier, B M; Prevost, C; Roux, R; Vicario, C

    2010-01-01

    Installation of the new photo-injector for the CTF3 drive beam (PHIN) has been completed on a stand-alone test bench. The photo-injector operates with a 2.5 cell RF gun at 3 GHz, using a Cs2Te photocathode illuminated by a UV laser beam. The test bench is equipped with transverse beam diagnostic as well as a 90-degree spectrometer. A grid of 100 micrometer wide slits can be inserted for emittance measurements. The laser used to trigger the photo-emission process is a Nd:YLF system consisting of an oscillator and a preamplifier operating at 1.5 GHz and two powerful amplifier stages. The infrared radiation produced is frequency quadrupled in two stages to obtain the UV. A Pockels cell allows adjusting the length of the pulse train between 50 nanoseconds and 50 microseconds. The nominal train length for CTF3 is 1.272 microseconds (1908 bunches). The first electron beam in PHIN was produced in November 2008. In this paper, results concerning the operation of the laser system and measurements performed to characte...

  4. 竞争型公共设施区位决策--概念、选址原则及模型构建%Competitive Public Facilities Location Decision:Concept, Location Selection Principle and Model Construction

    Institute of Scientific and Technical Information of China (English)

    宋正娜

    2016-01-01

    竞争型公共设施竞争性、公益性并存,其区位决策相对更加复杂。首先提出了“竞争型公共设施”的概念,指出“兼顾效率与公平的空间均衡”是其选址的基本原则,并概括出具体选址要求:遵循供需双方的空间相互作用模式、限制至邻近设施的最大出行成本、追求总出行成本最小化、约束设施规模门槛、与低层级设施在出行成本上相区分等。其次构建了基于概率分配规则的重力P中值模型,通过纳入设施规模因子实现区位和规模同步求解,并对邻近设施最大出行成本和设施最小规模进行约束,以实现空间公平-效率、服务质量公平与规模效率等多重目标。最后经过实证检验,优化后的设施布局更为均衡合理。%Competitive public facilities are both public-welfare and competitive, among them the comprehen-sive hospitals are most representative. Their location decision is relatively more complicated. This study aims to solve the problem that how to seek the optimal locations of such facilities. First of all, this study puts for-ward the concept of“competitive public facilities”which had been not defined systematically and normatively, pointed out that“the spatial equilibrium to coordinate the efficiency and equity”is the basic principle in loca-tion selection of competitive public facilities, and summarized a series of location requirements that they are to abide by the spatial interaction between the supply and demand, to limit the extreme travel cost from the settle-ment to the nearest facilities, to minimize the weighted total travel cost, to restrain the facility scale threshold, and to distinguish appropriately in spatial distribution between the higher level competitive public facilities and the ones. Secondly, gravity P median model was constructed with the probability distribution to replace the proximity rule by embedding the improved Huff probability model

  5. Combining Facility Location and Routing Decisions in Sustainable Urban Freight Distribution under Horizontal Collaboration: How Can Shippers Be Benefited?

    National Research Council Canada - National Science Library

    Hanan Ouhader; Malika El Kyal

    2017-01-01

      This article investigates the potential economic, environmental, and social effects of combining depot location and vehicle routing decisions in urban road freight transportation under horizontal collaboration...

  6. 停车换乘设施选址研究城市轨道交通%Studies on Park-and-Ride Facility Location for Transit

    Institute of Scientific and Technical Information of China (English)

    王显光; 任伟; 刘振国

    2013-01-01

    From viewpoint of two aspects of location and size of park-and-ride facility for urban rail transit, new and expanded projects shall take them into consideration. By using path-based user equilibrium assignment model and multi-mode assignment method, a model based on minimization of investment at park-and-ride facility location for city outskirts is established.%从选址和规模2方面考虑新建和扩建城市轨道交通停车换乘设施,采用基于路径的用户平衡配流模型和多方式配流方法,建立了基于投资最小化的城市外围停车换乘设施选址模型。

  7. Flow-Interception Facility Location Problem under Competitive Conditions%竞争环境下截流设施选址问题

    Institute of Scientific and Technical Information of China (English)

    申瑞玲; 霍佳震

    2013-01-01

      We consider a facility location model for locating a set of new facilities that compete for customer demand with each other, as well as with some pre-existing facilities both belong to the entity and the competitor , to capture the maximum profit of the entity.According to Huff gravity model, the probability that a customer se-lects a certain facility is proportional to its attractiveness and inversely proportional to the distance to the facility , we suppose the facility construction cost is relevant to its attractiveness , the problem is formulated as a non-linear integer program and solved by greedy algorithm .The numerical analysis indicates that the model and the method are practical.%  研究企业新建设施时,市场上已有设施存在的情况下,使本企业总体利润最大的截流设施选址问题。在一般截留设施选址模型的基础上引入引力模型,消费者到某个设施接受服务的概率与偏离距离及设施的吸引力相关,同时设施的建设费用与设施吸引力正相关,建立非线性整数规划模型并使用贪婪算法进行求解。数值分析表明,该算法求解速度快,模型计算精度较高。

  8. Locating, quantifying and characterising radiation hazards in contaminated nuclear facilities using a novel passive non-electrical polymer based radiation imaging device.

    Science.gov (United States)

    Stanley, S J; Lennox, K; Farfán, E B; Coleman, J R; Adamovics, J; Thomas, A; Oldham, M

    2012-06-01

    This paper provides a summary of recent trials which took place at the US Department of Energy Oak Ridge National Laboratory (ORNL) during December 2010. The overall objective for the trials was to demonstrate that a newly developed technology could be used to locate, quantify and characterise the radiological hazards within two separate ORNL hot cells (B and C). The technology used, known as RadBall(®), is a novel, passive, non-electrical polymer based radiation detection device which provides a 3D visualisation of radiation from areas where effective measurements have not been previously possible due to lack of access. This is particularly useful in the nuclear industry prior to the decommissioning of facilities where the quantity, location and type of contamination are often unknown. For hot cell B, the primary objective of demonstrating that the technology could be used to locate, quantify and characterise three radiological sources was met with 100% success. Despite more challenging conditions in hot cell C, two sources were detected and accurately located. To summarise, the technology performed extremely well with regards to detecting and locating radiation sources and, despite the challenging conditions, moderately well when assessing the relative energy and intensity of those sources. Due to the technology's unique deployability, non-electrical nature and its directional awareness the technology shows significant promise for the future characterisation of radiation hazards prior to and during the decommissioning of contaminated nuclear facilities.

  9. Location for new research facility determined X-ray laser XFEL to be realized in the federal states of Hamburg and Schleswig-Holstein starting in 2006

    CERN Multimedia

    2003-01-01

    "...The site for the XFEL has now been determined by the research center DESY (Deutsches Elektronen-Synchrotron); it was announced today at a press conference in Hamburg. The 3.3-kilometer-long facility is to be located in the federal states of Hamburg and Schleswig-Holstein. It will begin on the DESY site in Hamburg-Bahrenfeld and run in a north-western direction to the town of Schenefeld (district of Pinneberg), which borders on Hamburg" (1 page).

  10. A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1.

    Science.gov (United States)

    García-Rodríguez, Luis J; De Piccoli, Giacomo; Marchesi, Vanessa; Jones, Richard C; Edmondson, Ricky D; Labib, Karim

    2015-10-15

    Defects during chromosome replication in eukaryotes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA replication forks. Work with budding yeast showed that the 'alternative clamp loader' known as Ctf18-RFC acts by an unknown mechanism to activate the checkpoint kinase Rad53, which then mediates much of the checkpoint response. Here we show that budding yeast Ctf18-RFC associates with DNA polymerase epsilon, via an evolutionarily conserved 'Pol ϵ binding module' in Ctf18-RFC that is produced by interaction of the carboxyl terminus of Ctf18 with the Ctf8 and Dcc1 subunits. Mutations at the end of Ctf18 disrupt the integrity of the Pol ϵ binding module and block the S-phase checkpoint pathway, downstream of the Mec1 kinase that is the budding yeast orthologue of mammalian ATR. Similar defects in checkpoint activation are produced by mutations that displace Pol ϵ from the replisome. These findings indicate that the association of Ctf18-RFC with Pol ϵ at defective replication forks is a key step in activation of the S-phase checkpoint.

  11. Injury crashes with bicyclists at roundabouts: influence of some location characteristics and the design of cycle facilities.

    Science.gov (United States)

    Daniels, Stijn; Brijs, Tom; Nuyts, Erik; Wets, Geert

    2009-01-01

    Previous research indicated that conversions of intersections into roundabouts appear to increase the number of injury crashes with bicyclists. However, it was assumed that the effectiveness of roundabouts could vary according to some differences in design types of cycle, facilities and other geometrical factors. Regression analyses on effectiveness-indices resulting from a before-and-after study of injury crashes with bicyclists at 90 roundabouts in Flanders, Belgium. Regarding all injury crashes with bicyclists, roundabouts with cycle lanes appear to perform significantly worse compared to three other design types (mixed traffic, separate cycle paths, and grade-separated cycle paths). Nevertheless, an increase of the severest crashes was noticed, regardless of the design type of the cycle facilities. Roundabouts that are replacing signal-controlled intersections seem to have had a worse evolution compared to roundabouts on other types of intersections. The results might affect design guidelines for roundabouts, particularly for the accommodation of bicyclists.

  12. 服务能力受损情景下的应急设施选址模型%Emergency facility location model under service ability damage scenarios

    Institute of Scientific and Technical Information of China (English)

    俞武扬

    2016-01-01

    考虑突发事件造成应急设施服务能力受损的情景,通过最大、最小临界覆盖距离定义应急设施对需求点的应急服务质量,在满足需求点最低服务质量和数量要求条件下,以最大化加权服务质量期望值为目标建立应急设施选址模型。设计了一种基于模拟退火的求解算法,通过对临界覆盖距离、最低服务质量要求、设施服务能力等参数的数值实验,表明了所提出模型与算法可为解决应急设施选址决策提供有益的参考。%Considering the scenarios that emergencies damage the service abilities of some emergency facilities, service quantities are defined, among emergency facilities and demand points, by using the maximum and minimum critical coverage distance. An emergency facility location model is established within the objective to maximizing overall service quality expectation while ensuring the minimum service quality and quantity requirements. In order to solve this model, an efficient algorithm is designed based on the simulated annealing algorithm. Numerical experiments on the number of emergency facilities, the critical coverage range, the minimum service quality are conducted, these results show that the proposed model and algorithm can give a useful reference for the decision of emergency facility location.

  13. RF-Breakdown kicks at the CTF3 two-beam test stand

    CERN Document Server

    Palaia, Andrea; Muranaka, Tomoko; Ruber, Roger; Ziemann, V; Farabolini, W

    2012-01-01

    The measurement of the effects of RF-breakdown on the beam in CLIC prototype accelerator structures is one of the key aspects of the CLIC two-beam acceleration scheme being addressed at the Two-beam Test Stand (TBTS) at CTF3. RF-breakdown can randomly cause energy loss and transverse kicks to the beam. Transverse kicks have been measured by means of a screen intercepting the beam after the accelerator structure. In correspondence of a RFbreakdown we detect a double beam spot which we interpret as a sudden change of the beam trajectory within a single beam pulse. To time-resolve such effect, the TBTS has been equipped with five inductive Beam Position Monitors (BPMs) and a spectrometer line to measure both relative changes of the beam trajectory and energy losses. Here we discuss the methodology used and we present the latest results of such measurements

  14. Integrating multi-criteria techniques with geographical information systems in waste facility location to enhance public participation.

    Science.gov (United States)

    Higgs, Gary

    2006-04-01

    Despite recent U.K. Government commitments' to encourage public participation in environmental decision making, those exercises conducted to date have been largely confined to 'traditional' modes of participation such as the dissemination of information and in encouraging feedback on proposals through, for example, questionnaires or surveys. It is the premise of this paper that participative approaches that use IT-based methods, based on combined geographical information systems (GIS) and multi-criteria evaluation techniques that could involve the public in the decision-making process, have the potential to build consensus and reduce disputes and conflicts such as those arising from the siting of different types of waste facilities. The potential of these techniques are documented through a review of the existing literature in order to highlight the opportunities and challenges facing decision makers in increasing the involvement of the public at different stages of the waste facility management process. It is concluded that there are important lessons to be learned by researchers, consultants, managers and decision makers if barriers hindering the wider use of such techniques are to be overcome.

  15. Preliminary test results from the CELSS Test Facility Engineering Development Unit

    Science.gov (United States)

    Kliss, Mark H.; Macelroy, R. D.; Blackwell, C. C.; Borchers, B. A.; Drews, M. E.; Longabaugh, J. R.; Yendler, B. S.; Zografos, A. I.

    1994-01-01

    As part of the NASA Controlled Ecological Life Support System (CELSS) Program, a CELSS Test Facility (CTF) is being planned for installation on the Space Station. The CTF will be used to provide data on the productivity and efficiency of a variety of CELSS higher plant crops grown in the microgravity environment of the Space Station. Tight environmental control will be maintained while data on gas exchange rates and biomass accumulation rates are collected. In order to obtain an early realistic determination of the subsystem and system requirements necessary to provide the environmental conditions specified for CTF crop productivity experiments, an Engineering Development Unit (EDU) has been designed, constructed and is in the process of subsystem and system testing at NASA Ames Research Center. The EDU is a ground test-bed which will be used to characterize the integrated performance of major subsystem technologies, to evaluate hardware candidates and control strategies required for the CTF, and to further define the ability to meet CTF requirements within present Space Station constraints. This paper reviews the functional requirements for the EDU, and focuses on the performance evaluation and test results of the various subsystems. Preliminary integrated performance results and control system operation are addressed, and plans for future science and technology testing are discussed.

  16. Beam-loading Compensation Experiment in the CLIC Test Facility. Modelling and Simulation

    CERN Document Server

    Kononenko, Oleksiy; Grudiev, Alexej; Tecker, Frank

    2013-01-01

    Transient beam-loading in the main linac is an important performance issue for a Compact Linear Collider (CLIC) study. In order to keep the luminosity losses less than 1%, the rms bunch-to-bunch relative energy spread must be below 0.03%. Beam-loading model and a compensation scheme, which meet this requirement, have been recently developed for CLIC. In this paper we propose ways to confirm the feasibility of the compensation scheme experimentally in the CLIC Test Facility (CTF3). As a part of this study a CTF3-specific model to simulate an RF power production is developed and the corresponding numerical results are discussed

  17. 社区公共体育设施选址规划研究%Research on Facilities Location Planning of Community Sports

    Institute of Scientific and Technical Information of China (English)

    杜长亮; 顾校飞; 李南

    2016-01-01

    社区公共体育设施建设是一项重要的政府民生工程,近年来,“健身圈”建设的提出为各地体育设施的建设提供了指导。“健身圈”设施的公益性,使用需求的连续分布及无明确设施位置候选点,使得设施的选址不同于一般选址问题。基于经济性原则并保持体育设施地点不变,构造公平性和效率性的区位覆盖模型和设施选址组合模型,求解社区需新增最少设施点数量及其位置。运用GIS技术和K‐means划分聚类方法处理连续居民区离散化问题,提取需求点。通过对需求点进行缓冲区分析,优化设施位置候选点,构建设施选址网络。在模型求解方面,结合运用GIS技术和LINGO软件对选址模型进行求解。最后,以无锡市为例,进行应用研究,并以坐标和二维地图形式清晰形象地表达求解结果。%The construction of fitness circle of community sports is a government project .Its public property ,continuous distribution of demand and none‐identified candidate set of facility location make it different from other facility location problem .On the premise of keeping the current sports facilities in original places ,based on principles of economy ,fairness and efficien‐cy ,an improved LSCP model and an combined model were established to acquire the minimal quantity and location of new facilities ,which can fully cover the community residents ’ demand . GIS technology and cluster theory were applied to scatter the continuous demand so as to ex‐tract the discrete demand points .The candidate set of facility location was also obtained by the buffer analysis of demand points using GIS .Finally ,the network of facility location was built , and the LSCP and combined model were solved by GIS technology and LINGO software .After taking Wuxi city for example to research ,the location result was obtained in text and two‐di‐mension map format .

  18. Effect of Carthami Tinctorii Fructus Herbal-acupuncture Solution(CTF-HAS on Gene Expression in HepG2 carcinomar cells by Proteomic Analysis

    Directory of Open Access Journals (Sweden)

    Lee Kyung-min

    2005-06-01

    Full Text Available Objective : It has long been known about the osteogenic effect of CTF-HAS on bone tissues. However, it has not been determined the effect of CTF-HAS on cancer cells. The purpose of this study is to screen the CTF-HAS mediated differentially expressed genes in cancer cells such as HepG2 hepatoma cells lines. Methods : CTF-HAS was prepared by boiling and stored at -70℃ until use. For proteomic analysis, total protein was analyzed by 2D gel electrophoresis and Q-TOF mass spectrometer. Results : In proteomic analysis, three spots were identified by 2D-gel electrophoresis and Q-TOF analysis. One down-regulated protein was heat shock 70kDa protein 5 and up-regulated proteins were chaperonin and 2-phospho -pyruvate-hydratase α-enolase by 1.5mg/㎖ of CTF-HAS. Discussion : Proteomic ananlysis approach were performed to screen the differential expression genes. The screened genes will be used for the better understanding in therapeutic effect of CTF-HAS on cancer field.

  19. Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast.

    Science.gov (United States)

    Kim, Jiyoung; Robertson, Kathryn; Mylonas, Katie J L; Gray, Fiona C; Charapitsa, Iryna; MacNeill, Stuart A

    2005-01-01

    Proliferating cell nuclear antigen loading onto DNA by replication factor C (RFC) is a key step in eukaryotic DNA replication and repair processes. In this study, the C-terminal domain (CTD) of the large subunit of fission yeast RFC is shown to be essential for its function in vivo. Cells carrying a temperature-sensitive mutation in the CTD, rfc1-44, arrest with incompletely replicated chromosomes, are sensitive to DNA damaging agents, are synthetically lethal with other DNA replication mutants, and can be suppressed by mutations in rfc5. To assess the contribution of the RFC-like complexes Elg1-RFC and Ctf18-RFC to the viability of rfc1-44, genes encoding the large subunits of these complexes have been deleted and overexpressed. Inactivation of Ctf18-RFC by the deletion of ctf18+, dcc1+ or ctf8+ is lethal in an rfc1-44 background showing that full Ctf18-RFC function is required in the absence of fully functional RFC. In contrast, rfc1-44 elg1Delta cells are viable and overproduction of Elg1 in rfc1-44 is lethal, suggesting that Elg1-RFC plays a negative role when RFC function is inhibited. Consistent with this, the deletion of elg1+ is shown to restore viability to rfc1-44 ctf18Delta cells.

  20. 基于工作负荷均衡的车辆拯救设施选址%Facility Location for Failure Rescuing Vehicles Considering Workload Equilibrium

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    交通事故车辆的拯救设施选址是车辆拯救服务的重要问题,选址不当易造成车辆拯救行业服务效率低下、市场行业的不规范、利益不均等一系列问题。针对这类问题,分析了俱乐部和政府引导两种服务模式下的拯救设施选址特点,并提出了针对车辆拯救的工作负荷概念。在不确定性救援路径行程时间条件下,建立以负荷均衡为目标的车辆拯救设施选址模型,以提高设施站点的运营效率和实现车辆拯救企业间的利益平衡。采用三种染色体形式的混合编码和随机模拟方法,设计基于遗传优化的求解算法。最后,通过仿真实例验证了算法的有效性。%Facility location is critical for failure vehicle rescuing during traffic accidents .Improper location of rescuing facilities may result in low service efficiency , unfair competition , and unequal interests between different service enterprises .Both the club-mode and the government dominated rescuing service modes are analyzed for those problems .Based on the definition of the workload equilibrium of rescuing service , the facility location model of vehicle rescuing is built up with consideration of uncertain travel time .The novel model aims to improve the operational efficiency of the rescuing facilities and balance the profits between enterprises for providing rescuing service .A hybrid coding method with three types of chromosomes and stochastic simulation technology are used , and an optimal algorithm based on genetic algorithm is designed for solving the proposed model .Lastly, a case study is used to show the effectiveness of the model and the corresponding algorithm .

  1. The CTF3 team who performed the first electron beam recombination in an isochronous ring at CERN.

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 0210004_1: Part of CTF3 collaboration. From left to right: T. Ekelof (Uppsala), A. Gallo (LNF), P. Royer (Lausanne), F. Tecker (CERN), L. Rinolfi (CERN), A. Ferrari (Uppsala), R. Corsini (CERN), S. Quaglia, (LNF). Photo 0210004_2: A. Ferrari (left), T. Ekelof (middle) and A. Rydberg (right), from Uppsala University, Sweden, standing where the phase monitor HR.PHM60 is installed. Photo 0210004_4: A. Gallo (LNF) standing in front of the RF deflector designed by INFN-Frascati. Photo 0210004_7: The team who designed the CTF3 complex starting from the existing LEP Pre-Injector. From left to right L. Rinolfi, A. Ferrari, F. Tecker (standing up) and R. Corsini, P. Royer (kneeling down) in front of the electron transfer line between the linac and the combiner ring. Photo 0210004_9: The CTF3 team who performed the first electron beam recombination in an isochronous ring at CERN. From left to right, L. Rinolfi, P. Royer, F. Tecker, R. Corsini standing up in front of the two RF deflectors built at CERN and working...

  2. Comparative Analysis of CTF and Trace Thermal-Hydraulic Codes Using OECD/NRC PSBT Benchmark Void Distribution Database

    Directory of Open Access Journals (Sweden)

    M. Avramova

    2013-01-01

    Full Text Available The international OECD/NRC PSBT benchmark has been established to provide a test bed for assessing the capabilities of thermal-hydraulic codes and to encourage advancement in the analysis of fluid flow in rod bundles. The benchmark was based on one of the most valuable databases identified for the thermal-hydraulics modeling developed by NUPEC, Japan. The database includes void fraction and departure from nucleate boiling measurements in a representative PWR fuel assembly. On behalf of the benchmark team, PSU in collaboration with US NRC has performed supporting calculations using the PSU in-house advanced thermal-hydraulic subchannel code CTF and the US NRC system code TRACE. CTF is a version of COBRA-TF whose models have been continuously improved and validated by the RDFMG group at PSU. TRACE is a reactor systems code developed by US NRC to analyze transient and steady-state thermal-hydraulic behavior in LWRs and it has been designed to perform best-estimate analyses of LOCA, operational transients, and other accident scenarios in PWRs and BWRs. The paper presents CTF and TRACE models for the PSBT void distribution exercises. Code-to-code and code-to-data comparisons are provided along with a discussion of the void generation and void distribution models available in the two codes.

  3. Methodology for optimising location of new primary health care facilities in rural communities: a case study in KwaZulu-Natal, South Africa.

    Science.gov (United States)

    Tanser, Frank

    2006-10-01

    To develop a quantitative methodology to optimally site new primary health care facilities so as to achieve the maximum population level increase in accessibility to care. The study aims to test the methodology in a rural community characterised by considerable heterogeneity in population distribution and health care access. A geographical information system was used to estimate travel time to the nearest primary health care facility for each of the 26 000 homesteads in the subdistrict. The homestead's travel time estimate was then converted into an impedance to care estimate using distance decay (in clinic use) data obtained from the subdistrict. A map of total person impedance/km(2) was then produced using a 3 km standard Gaussian filter. The resulting map was used to site a test clinic in the largest contiguous area of high person impedance. Hlabisa health subdistrict, KwaZulu-Natal, South Africa. The population level increase in accessibility that would be achieved by the construction of the test clinic would be 3.6 times the increase in accessibility achieved by the construction of the newest clinic in the subdistrict. The corresponding ratio for increasing clinic coverage (% of the population within 60 minutes of care) would be 4.7. The methodology successfully identifies a locality for a new facility that would maximise the population level increase in accessibility to care. The same principles used in this research could also be applied in other settings. The methodology is of practical value in health research and practice and provides a framework for optimising location of new primary health care facilities.

  4. Park Facilities, Boundaries were determined from parcel mapping lines & site specific items, such as shelter locations, were obtained by field GPS observation, Published in 2010, Not Applicable scale, Chippewa County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Park Facilities dataset current as of 2010. Boundaries were determined from parcel mapping lines & site specific items, such as shelter locations, were obtained...

  5. Lease Approval and Building Aid for Leased School Buildings and Facilities Located Off School Property (Pursuant to CR 155.8). Instruction Guide for Public School Districts Outside of New York City.

    Science.gov (United States)

    New York State Education Dept., Albany. Office of Facilities Planning.

    State regulations allow public school districts outside of New York City to apply for Building Aid on leasing costs involving instructional facilities for grades Pre-K through 12 located off school district property. This guide explains how the districts should proceed when applying for Building Aid on leased facilities. Attached is the…

  6. Training a Neural Network Via Large-Eddy Simulation for Autonomous Location and Quantification of CH4 Leaks at Natural Gas Facilities

    Science.gov (United States)

    Sauer, J.; Travis, B. J.; Munoz-Esparza, D.; Dubey, M. K.

    2015-12-01

    Fugitive methane (CH4) leaks from oil and gas production fields are a potential significant source of atmospheric methane. US DOE's ARPA-E MONITOR program is supporting research to locate and quantify fugitive methane leaks at natural gas facilities in order to achieve a 90% reduction in CH4 emissions. LANL, Aeris and Rice University are developing an LDS (leak detection system) that employs a compact laser absorption methane sensor and sonic anemometer coupled to an artificial neural network (ANN)-based source attribution algorithm. LANL's large-eddy simulation model, HIGRAD, provides high-fidelity simulated wind fields and turbulent CH4 plume dispersion data for various scenarios used in training the ANN. Numerous inverse solution methodologies have been applied over the last decade to assessment of greenhouse gas emissions. ANN learning is well suited to problems in which the training and observed data are noisy, or correspond to complex sensor data as is typical of meteorological and sensor data over a site. ANNs have been shown to achieve higher accuracy with more efficiency than other inverse modeling approaches in studies at larger scales, in urban environments, over short time scales, and even at small spatial scales for efficient source localization of indoor airborne contaminants. Our ANN is intended to characterize fugitive leaks rapidly, given site-specific, real-time, wind and CH4 concentration time-series data at multiple sensor locations, leading to a minimum time-to-detection and providing a first order improvement with respect to overall minimization of methane loss. Initial studies with the ANN on a variety of source location, sensor location, and meteorological condition scenarios are presented and discussed.

  7. A Hybrid Approach Using an Artificial Bee Algorithm with Mixed Integer Programming Applied to a Large-Scale Capacitated Facility Location Problem

    Directory of Open Access Journals (Sweden)

    Guillermo Cabrera G.

    2012-01-01

    Full Text Available We present a hybridization of two different approaches applied to the well-known Capacitated Facility Location Problem (CFLP. The Artificial Bee algorithm (BA is used to select a promising subset of locations (warehouses which are solely included in the Mixed Integer Programming (MIP model. Next, the algorithm solves the subproblem by considering the entire set of customers. The hybrid implementation allows us to bypass certain inherited weaknesses of each algorithm, which means that we are able to find an optimal solution in an acceptable computational time. In this paper we demonstrate that BA can be significantly improved by use of the MIP algorithm. At the same time, our hybrid implementation allows the MIP algorithm to reach the optimal solution in a considerably shorter time than is needed to solve the model using the entire dataset directly within the model. Our hybrid approach outperforms the results obtained by each technique separately. It is able to find the optimal solution in a shorter time than each technique on its own, and the results are highly competitive with the state-of-the-art in large-scale optimization. Furthermore, according to our results, combining the BA with a mathematical programming approach appears to be an interesting research area in combinatorial optimization.

  8. Harbor Facility Locations - USACE IENC

    Data.gov (United States)

    Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

  9. Substance Abuse Treatment Facility Locator

    Science.gov (United States)

    ... nbspPersons who have experienced intimate partner violence, domestic violence   Children with serious emotional disturbance (SED)   Persons with serious mental illness (SMI)   Persons with Alzheimer's or dementia  & ...

  10. VA Health Care Facilities Locator

    Science.gov (United States)

    ... Inside the Media Room Public Affairs News Releases Speeches Videos Publications National Observances Veterans Day Memorial Day Celebrating America's Freedoms Special Events Adaptive Sports Program Creative Arts Festival ...

  11. Mooring Facility Locations - USACE IENC

    Data.gov (United States)

    Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

  12. Modelling the role of CtfA/B in reverse shift continuous culture experiments of Clostridium acetobutylicum.

    Science.gov (United States)

    Thorn, Graeme J; King, John R

    2016-06-01

    In continuous phosphate-limited conditions, under pH control from high pH (pH ≳ 5.2) to low pH (pH ≲ 5.2), the metabolism of the Gram-positive bacterium Clostridium acetobutylicum,switches from acid to solvent production. Three main enzymes are responsible for the shift, acetoacetate decarboxylase (Adc), alcohol dehydrogenase (AdhE1/2) and a CoA-transferase (CtfA/B), which are produced in increased quantities during solventogenesis. A two-population model, Millat et al. (2013) and fitted to such 'forward'-shift data, can explain this, as well as observed changes in optical density immediately following the shift: an acidogenic subpopulation is washed out and a solventogenic subpopulation grows in its place, each with distinct physiologies and proteomes. We fit this model to a 'reverse'-shift experiment, where the pH is increased from solventogenic to acidogenic conditions. We find corresponding changes in reaction rates, with AdhE1 and Adc production falling, as in the 'forward' experiments; however, for CtfA/B, the best fit surprisingly arises from the same level of production in both conditions. We propose experiments that would test whether this is a model artefact or accurately reflects cultures shifted in this reverse direction, and, if true, may suggest that over-expressing CtfA/B in both solventogenic and acidogenic conditions could improve the efficiency of fermentation. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Facility Configuration Study of the High Temperature Gas-Cooled Reactor Component Test Facility

    Energy Technology Data Exchange (ETDEWEB)

    S. L. Austad; L. E. Guillen; D. S. Ferguson; B. L. Blakely; D. M. Pace; D. Lopez; J. D. Zolynski; B. L. Cowley; V. J. Balls; E.A. Harvego, P.E.; C.W. McKnight, P.E.; R.S. Stewart; B.D. Christensen

    2008-04-01

    A test facility, referred to as the High Temperature Gas-Cooled Reactor Component Test Facility or CTF, will be sited at Idaho National Laboratory for the purposes of supporting development of high temperature gas thermal-hydraulic technologies (helium, helium-Nitrogen, CO2, etc.) as applied in heat transport and heat transfer applications in High Temperature Gas-Cooled Reactors. Such applications include, but are not limited to: primary coolant; secondary coolant; intermediate, secondary, and tertiary heat transfer; and demonstration of processes requiring high temperatures such as hydrogen production. The facility will initially support completion of the Next Generation Nuclear Plant. It will secondarily be open for use by the full range of suppliers, end-users, facilitators, government laboratories, and others in the domestic and international community supporting the development and application of High Temperature Gas-Cooled Reactor technology. This pre-conceptual facility configuration study, which forms the basis for a cost estimate to support CTF scoping and planning, accomplishes the following objectives: • Identifies pre-conceptual design requirements • Develops test loop equipment schematics and layout • Identifies space allocations for each of the facility functions, as required • Develops a pre-conceptual site layout including transportation, parking and support structures, and railway systems • Identifies pre-conceptual utility and support system needs • Establishes pre-conceptual electrical one-line drawings and schedule for development of power needs.

  14. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  15. Environmental Toxicology Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Fully-equipped facilities for environmental toxicology research The Environmental Toxicology Research Facility (ETRF) located in Vicksburg, MS provides over 8,200 ft...

  16. Licensed Healthcare Facilities

    Data.gov (United States)

    California Department of Resources — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  17. Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response.

    Science.gov (United States)

    Crabbé, Laure; Thomas, Aubin; Pantesco, Véronique; De Vos, John; Pasero, Philippe; Lengronne, Armelle

    2010-11-01

    Maintenance of genome integrity relies on surveillance mechanisms that detect and signal arrested replication forks. Although evidence from budding yeast indicates that the DNA replication checkpoint (DRC) is primarily activated by single-stranded DNA (ssDNA), studies in higher eukaryotes have implicated primer ends in this process. To identify factors that signal primed ssDNA in Saccharomyces cerevisiae, we have screened a collection of checkpoint mutants for their ability to activate the DRC, using the repression of late origins as readout for checkpoint activity. This quantitative analysis reveals that neither RFC(Rad24) and the 9-1-1 clamp nor the alternative clamp loader RFC(Elg1) is required to signal paused forks. In contrast, we found that RFC(Ctf18) is essential for the Mrc1-dependent activation of Rad53 and for the maintenance of paused forks. These data identify RFC(Ctf18) as a key DRC mediator, potentially bridging Mrc1 and primed ssDNA to signal paused forks.

  18. Duality in constrained location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1987-01-01

    The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated.......The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated....

  19. Duality in constrained location problems

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1987-01-01

    The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated.......The dual of a facility location problem with general norms, distance constraints, and linear constraints is formulated....

  20. Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.

    Science.gov (United States)

    McLellan, Jessica; O'Neil, Nigel; Tarailo, Sanja; Stoepel, Jan; Bryan, Jennifer; Rose, Ann; Hieter, Philip

    2009-12-01

    Somatic mutations causing chromosome instability (CIN) in tumors can be exploited for selective killing of cancer cells by knockdown of second-site genes causing synthetic lethality. We tested and statistically validated synthetic lethal (SL) interactions between mutations in six Saccharomyces cerevisiae CIN genes orthologous to genes mutated in colon tumors and five additional CIN genes. To identify which SL interactions are conserved in higher organisms and represent potential chemotherapeutic targets, we developed an assay system in Caenorhabditis elegans to test genetic interactions causing synthetic proliferation defects in somatic cells. We made use of postembryonic RNA interference and the vulval cell lineage of C. elegans as a readout for somatic cell proliferation defects. We identified SL interactions between members of the cohesin complex and CTF4, RAD27, and components of the alternative RFC(CTF18) complex. The genetic interactions tested are highly conserved between S. cerevisiae and C. elegans and suggest that the alternative RFC components DCC1, CTF8, and CTF18 are ideal therapeutic targets because of their mild phenotype when knocked down singly in C. elegans. Furthermore, the C. elegans assay system will contribute to our knowledge of genetic interactions in a multicellular animal and is a powerful approach to identify new cancer therapeutic targets.

  1. 成本与半径优化的设施选址问题%Facility Location Problem with Cost and Radius Optimization

    Institute of Scientific and Technical Information of China (English)

    翁克瑞; 杨超

    2012-01-01

    The facility location problem with cost and radius optimization (FLCRO) has a wide range of applications in emergency response, logistics, maintenance service as well as express delivery. By considering the relationship of response time, service benefits and service costs, the problem seeks a decision on whether the distant customers are brought into the range of service radius or not. Both service cost and service radius are taken into consideration in the model. We construct a mixed 0 — 1 integer programming model for the problem and present a 7. 853 + e-approximation algorithm for FLCRO on a plane. We also provided a heuristic algorithm based on benders' decomposition which is very effective in solving FLCRO.%成本与半径优化的服务设施选址问题(CROFL)广泛应用于应急服务、快递、维修网络等领域,其特点是考虑了响应速度与服务价格、成本之间的关系,根据净收益最大化或者成本最小化的原则自动判断是否将偏远的“需求点”纳入服务半径之内,实现服务成本与服务半径的双重优化.建立了CROFL的混合整数规划模型,构造了求解平面CROFL的7.853+ε-近似算法,并提供了求解一般CROFL的Benders’分解算法,计算实验显示,Benders’分解算法具有非常高的求解效率与求解质量.

  2. Discussion about the Model of Single Facility Location in Subject of Logistics Management%《物流管理》课程中"单设施选址模型"教学探讨

    Institute of Scientific and Technical Information of China (English)

    陈文

    2015-01-01

    设施选址是物流管理的重要环节,其中单设施选址模型是最基本、也是最重要的选址模型. 重心法是求解单设施选址模型的重要方法,因此,本文从重心法原理、重心法计算步骤及重心法的程序实现等环节对"重心法"的教学进行了设计.%Facility location is an important link of logistics management, and the model of single facility location is the most basic and important model in facility Location. The gravity method is an important method to solve the model of single facility loca-tion, so the principle of the gravity method、the calculation steps of the gravity method and the program realization of the gravity method will be discussed to improve teaching methodology in this paper.

  3. Overview of Linear Collider Test Facilities and Results

    CERN Document Server

    Hayano, H

    2004-01-01

    Linear Collider technology will be recommended by the International Technology Recommendation Panel (ITRP) to the International Linear Collider Steering Committee (ILCSC), soon. Towards this recommendation, many efforts of the developments and the output results of each technology have been made to satisfy the requirements of the technical review committee report (TRC). The test facilities of each linear collider design are the place of the key technology demonstration and realization. The overview of the LC test facilities activities and outputs of TTF, NLCTA, ATF/GLCTA and CTF are summarized and reviewed.

  4. Western Canada study of animal health effects associated with exposure to emissions from oil and natural gas field facilities. Study design and data collection II. Location of study herds relative to the oil and gas industry in Western Canada.

    Science.gov (United States)

    Waldner, Cheryl L

    2008-01-01

    During the late part of 2000 and early months of 2001, project veterinarians recruited 205 beef herds to participate in a study of the effects of emissions from the upstream oil and gas industry on cattle reproduction and health. Researchers developed herd-selection criteria to optimize the range of exposure to facilities, including oil and gas wells, battery sites, and gas-gathering and gas-processing facilities across the major cattle-producing areas of Western Canada. Herds were initially selected on the basis of a ranking system of exposure potential on the basis of herd-owner reports of the locations of their operations in relation to oil and gas industry facilities. At the end of the study, researchers summarized data obtained from provincial regulatory agencies on facility location and reported flaring and venting volumes for each herd and compared these data to the original rankings of herd-exposure potential. Through this selection process, the researchers were successful in obtaining statistically significant differences in exposure to various types of oil and gas facility types and reported emissions among herds recruited for the study.

  5. Hazardous Material Storage Facilities and Sites, Tier II Reporting locations, Published in 2005, 1:4800 (1in=400ft) scale, Iredell County GIS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hazardous Material Storage Facilities and Sites dataset, published at 1:4800 (1in=400ft) scale, was produced all or in part from Field Survey/GPS information...

  6. Prisons and Correctional Facilities, Prison point locations in Iredell County, NC, Published in 2009, 1:2400 (1in=200ft) scale, Iredell County GIS.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Prisons and Correctional Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2009. It is...

  7. Industrial Manufacturing Facilities, Coweta County, Georgia WinPak Location Map, Published in 2004, 1:12000 (1in=1000ft) scale, Chattahoochee-Flint Regional Development.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Industrial Manufacturing Facilities dataset, published at 1:12000 (1in=1000ft) scale, was produced all or in part from Hardcopy Maps information as of 2004. It...

  8. Ambulatory Surgical Facilities, Identify the locations of Ambulatory Surgical Centers, Published in 2012, 1:2400 (1in=200ft) scale, Miami-Dade County, Information Technology Department.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Ambulatory Surgical Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2012. It is described as...

  9. Park Facilities, County-owned park locations and park boundaries., Published in 2013, 1:12000 (1in=1000ft) scale, Clark County Planning and Zoning Department.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Park Facilities dataset, published at 1:12000 (1in=1000ft) scale, was produced all or in part from Field Observation information as of 2013. It is described as...

  10. A Synchrotron-based Facility for Location and In-situ Chemical and Mineralogical Analysis of ~10 mm Particles From Comets and Asteroids Returned to Earth in Aerogel

    Science.gov (United States)

    Flynn, G. J.; Lanzirotti, A.; Sutton, S. R.

    In January 2006, NASA's Stardust spacecraft is expected to deliver to Earth more than 1,000 dust particles collected in aerogel capture cells from the coma of Comet Wild-2. These dust particles, which impacted the aerogel surface at ˜ 6 km/sec, are expected to produce cone-shaped entry tracks, each about 100 to 200 times as long as the particle diameter, with the particle at the end of the track. However, weak particles may fragment during capture, leaving debris along the sides of the entry track. In addition, the impact of numerous sub-micron, carbon-rich particles (like the CHON particles identified by the Giotto and VEGA spacecraft at Comet Halley) may discolor the surface of the aerogel, interfering with the visual location/identification of the captured particles. Extraction of these particles from the aerogel will, eventually, be required in order to perform analyses that cannot be performed in-situ. However, extraction involves the risk of particle contamination or particle loss. For this reason, we have developed techniques to employ a synchrotron-based x-ray microprobe and x-ray diffraction facility on Beamline X26A of the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory for the in-situ chemical and mineralogical characterization of the Wild-2 particles and particles returned in aerogel capture cells on future space missions. This facility is designed to perform: 3-D particle location by detection of Fe-fluorescence from ˜ 10 μ m particles, in case carbon-rich debris reduces the optical transparency of the aerogel, semi-quantitative x-ray fluorescence chemical analysis on particles ˜ 10 μ m in size for the elements from Ca to Sr, mineral identification by x-ray diffraction on particles ˜ 10 μ m in size, oxidation state characterization by X-ray Absorption Near-Edge Structure (XANES) spectroscopy of Fe, Cr, etc. in ˜ 10 μ m particles, chemical analysis of fragments and vapor deposited along the entry track, to reconstruct

  11. Reliable Connected Facility Location Problem in Emergency Management Based on Failure Scenarios%基于损毁情景的可靠连通应急设施选址问题

    Institute of Scientific and Technical Information of China (English)

    朱建明

    2012-01-01

      Emergency facility location is an important problem in emergency management. In real emergency response situations, resources are always transported among all facilities because of huge demands. At the same time, facilities may be destroyed by the disaster, and services have to cut down. In this paper, considering all facility failure scenarios and transportation time among the facilities, a reliable connected facility location model is formulated, which is a 0-1 integer programming with nonlinear objective functions. Since this model is NP-hard, an efficient algorithm is designed based on the genetic algorithm. Then, comparing with classical facility location models, experiment results show that both the model and algorithm presented in this paper are useful for robust decisions of emergency facility location.%  应急设施选址问题是应急管理中的重要问题,在实际应急处置过程中,常常需要设施两两之间的资源调度,同时灾害可能导致已有设施的损毁,造成设施服务的中断,因此,本文同时考虑设施可能的损毁情景以及设施两两之间的调度时间,建立了可靠连通应急设施选址模型,该模型是带有非线性目标函数的0-1整数规划,属于NP-困难问题,基于遗传算法为模型设计了有效的求解方法,并通过算例与经典选址模型进行比较,说明了本文提出的模型与算法在解决应急设施选址决策鲁棒性方面具有一定的应用价值

  12. 设施选址问题中的基础模型与求解方法比较%A Comparative Research of Facility Location Models and Algorithms

    Institute of Scientific and Technical Information of China (English)

    孟醒; 张景秋; 朱海勇

    2012-01-01

    设施选址问题广泛存在于国民经济的各行业中。通过回顾选址问题的发展,重点比较分析中值选址问题与覆盖选址问题中的两类模型,并对模型在实践应用中的求解方法进行列举和总结比较,梳理设施选址问题的相关研究,以期为选址决策者提供参考。%Facility location is an issue in many industries of national economy. The development of facility location is reviewed, and two classical facility location models, p-media model and covering models, were compared and analyzed. Location problems are common optimization problems, many of which are NP-hard. There have been many algorithms to solve the problems. The solutions are provided and summarized, and relevant researches are sorted for the reference of decision makers to deal with the problem more efficiently.

  13. Weather Station and Sensor Locations, Prince George's County Earth Networks Owned Weather Stations located on County Facilities, Published in 2005, 1:2400 (1in=200ft) scale, Prince George's County Office of Information Technology and Communications.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Weather Station and Sensor Locations dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Published Reports/Deeds information as of...

  14. Assisted Living Facilities, Locations of Assisted Living Facilities identifed visually and placed on the Medical Multi-Hazard Mitigation layer., Published in 2006, 1:1200 (1in=100ft) scale, Noble County Government.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Assisted Living Facilities dataset, published at 1:1200 (1in=100ft) scale, was produced all or in part from Field Observation information as of 2006. It is...

  15. North Slope, Alaska ESI: FACILITY (Facility Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for oil field facilities for the North Slope of Alaska. Vector points in this data set represent oil field facility locations. This data...

  16. 救援时间限制下高速公路网应急设施点选址模型%Emergency Facility Location Model of Expressway Network Within Limitation of Rescue Time

    Institute of Scientific and Technical Information of China (English)

    赵琳娜; 戴帅; 巩建国

    2015-01-01

    The emergency facility location is a key problem in the field of expressway emergency man⁃agement. A method of optimizing the emergency facility location on the expressway network by the math⁃ematical modeling was proposed. Firstly, the layout characteristics of emergency facility demand on the expressway network was analyzed, and the emergency demand under the specific traffic accident was de⁃termined in terms of the accident probability, the accident influence scope and the average traffic flow volumes. Secondly, the emergency facility location model was established based on the demand analysis. In the emergency facility location model, the facility points′coverage condition was determined by the rescue time limitation, and the facility points were chosen to build emergency facility within the condi⁃tion of rapid rescue time and sufficient rescue supplies. Finally, the method of the heuristic algorithm based on the Lagrangian Relaxation to solve this model was introduced. The emergency facility location model aimed at emergency demand on the expressway network was verified to be effective and enforce⁃able by a computational experiment, which guaranteed for the rescue time and offered a new idea for the emergency facility location.%应急资源布局问题是高速公路应急管理的关键。通过建立数学模型,提出一种优化高速公路网中应急设施点布局方法。首先,通过分析高速公路网中应急需求的布局特点,依据事故发生概率、事故影响范围和路段平均车流量确定在某个交通事故情形下需求点的应急需求。然后,基于需求分析建立应急设施点选址模型。通过救援时间限制确定设施点的覆盖条件,选择救援时间短、物资供给能力强的待选点建立设施点。最后,采用基于拉格朗日松弛的启发式算法对模型进行求解。通过计算实例验证,该布局方法针对高速公路网的应急需求,保障了应

  17. AN APPROXIMATION ALGORITHM FOR THE SOFT-CAPACITATED DYNAMIC FACILITY LOCATION PROBLEM%软容量约束的动态设施选址问题的近似算法

    Institute of Scientific and Technical Information of China (English)

    姜春艳; 李改弟

    2012-01-01

    考虑软容量约束的动态设施选址问题.假设设施的开放费用及连接费用都与时间有关,而且每一个设施均有容量约束.对此问题给出了第一个近似比为6的原始对偶(组合)算法.运行贪婪增加程序后,近似比进一步改进到3.7052.%The paper considers the soft-capacitated dynamic facility location problem (SCDFLP). It is assumed that the facility open cost and the connection cost are time-dependent, and each facility has a capacity. We present the first primal-dual (combinatorial) approximation algorithm for the problem with approximation ratio 6 . We further improve the approximation ration to 3.7052 using greedy augmentation scheme.

  18. 精伊霍线机务设备选点、布点方案比选%Scheme Comparison for Selection and Arrangement of Locomotive Facility Location in Jinghe-Yili-Korgas Railway

    Institute of Scientific and Technical Information of China (English)

    高林生

    2012-01-01

    精伊霍线是乌鲁木齐铁路局管辖内的第一条电化铁路,由于相邻线既有机务设备均为内燃设备,所以本线机务设备选点、布点不当不仅影响近期使用效率,有可能还会在远期造成大量废弃工程.从客货流预测、相邻线既有机务设备、乌鲁木齐铁路局中长期规划以及自然条件与区域环境等方面进行大量的分析比较,并结合机务选点、布点一般原则形成本线机务设备选点、布点最终方案,为后续同类项目规划设计提供了很好的借鉴.%Jinghe-Yili-Korgas Railway is the first electrified railway under the jurisdiction of Urumqi Railway Administration. Improper selection and arrangement of locomotive facilities location in this railway will not only affect the recent utilization ratio but also result in a lot of waste works in the future because the existing locomotive facilities in adjacent railways are diesel facilities. This paper carries out extensive analysis and comparisons from these respects of prediction of passenger and freight flow, existing locomotive facilities in adjacent railways, medium and long term planning of Urumqi Railway Administration, natural condition and regional environment, etc. The final scheme of the selection and arrangement of locomotive facilities location in this line has been formed according to the general principles of locomotive location selection and arrangement, and it can provide the better reference for the planning and designing of similar projects in the future.

  19. A Research on a GIS-Based Location Planning for“Fitness Circle” Facilities of Community Sports%基于 GIS 的城市社区体育“健身圈”设施选址研究

    Institute of Scientific and Technical Information of China (English)

    顾校飞; 李南; 陆慧玲

    2014-01-01

    社区体育“健身圈”建设是一项政府工程,其设施的公益性,使用需求的连续分布及无明确设施位置候选点使得“健身圈”设施的选址不同于一般选址问题。基于“健身圈”设施选址的公平性和效率性原则,构建改进的区位集覆盖模型,以求解使设施完全有效覆盖居民区的最少设施点数及其位置。并运用GIS技术,将连续居民区离散化提取需求点,以需求点缓冲区优化设施位置候选点,从而构建设施选址网络,求解选址模型。最后,以无锡市为例,进行应用研究,以文字及二维地图形式形象表达求解结果。对政府落实《全民健身条例》,建设城乡社区体育“健身圈”具有重要意义。%The construction of “fitness circle” of community sports is a government project .Its public property , continuous distribution of demand and none-identified candidate set of facility location make it different from other facility location .Based on principles of fairness and efficiency , an improved LSCP model is established to acquire the minimal quantity and location of facilities , which can fully cover the community residents'demand .By applying GIS technology , not only is the continuous demand scattered so as to extract the discrete demand points , the candidate set of facility location is also identified by the buffer of demand points.Finally, a network of facility location is built, and the LSCP model solved by GIS.After taking Wuxi city for example , the location result is obtained via text and two-dimension map format , which is significant for the implement of National Fitness Program as well as the construction of “fitness circle” of community sports .

  20. A Two-stage Robust Optimization Model for Emergency Facility Location Problems under Uncertainties%不确定环境下应急设施选址问题两阶段鲁棒优化模型

    Institute of Scientific and Technical Information of China (English)

    杜博; 周泓

    2016-01-01

    For emergency logistics management,decision making of supply distribution facility location is important. According to the uncertainties in emergencies,a two-stage robust optimization model for emer-gency facility location problems to achieve coordination between“pre-location”and“re-location”is pro-posed. In the first stage when demand,cost and facility disruption is uncertain,in the consideration of dif-ferent needs of pre-disaster planning,post-disaster response and facility re-location,a robust“pre-loca-tion”model is presented based on p-center model. In the second stage,with the acquisition of post-disas-ter information,a“re-location”model for building new facilities is presented based on reactive repairing and adjustment for previous strategies. A numerical study shows the model is more effective than traditional p-center model for emergency facility location.%对于应急物流管理而言,应急物资集散中心选址是一个重要的决策要素。针对应急突发事件的不确定性特征,本文提出了一个应急设施选址问题两阶段鲁棒优化模型,以实现“预选址—重选址”两者的协同优化。第一阶段在需求和成本变动、设施损毁存在不确定因素的情况下,综合考虑选址策略在灾前规划、灾后反应、设施重建阶段的不同需求,建立了一种基于p-center的鲁棒“预选址”模型;第二阶段针对灾后新信息的获得,建立了一种基于反应式修复和调整策略的新建设施“重选址”模型。算例分析表明,本文模型对于应急设施选址问题比传统p-center模型更为合理有效。

  1. RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells.

    Science.gov (United States)

    Im, Jun-Sub; Park, Soon-Young; Cho, Won-Ho; Bae, Sung-Ho; Hurwitz, Jerard; Lee, Joon-Kyu

    2015-01-01

    Though RecQL4 was shown to be essential for the initiation of DNA replication in mammalian cells, its role in initiation is poorly understood. Here, we show that RecQL4 is required for the origin binding of Mcm10 and Ctf4, and their physical interactions and association with replication origins are controlled by the concerted action of both CDK and DDK activities. Although RecQL4-dependent binding of Mcm10 and Ctf4 to chromatin can occur in the absence of pre-replicative complex, their association with replication origins requires the presence of the pre-replicative complex and CDK and DDK activities. Their association with replication origins and physical interactions are also targets of the DNA damage checkpoint pathways which prevent initiation of DNA replication at replication origins. Taken together, the RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.

  2. Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.

    Science.gov (United States)

    Jiang, Ying; Rigoglioso, Andrew; Peterhoff, Corrinne M; Pawlik, Monika; Sato, Yutaka; Bleiwas, Cynthia; Stavrides, Philip; Smiley, John F; Ginsberg, Stephen D; Mathews, Paul M; Levy, Efrat; Nixon, Ralph A

    2016-03-01

    β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked APP-βCTF generated by BACE1 (β-APP cleaving enzyme 1) to the development of endocytic abnormalities and cholinergic neurodegeneration in early AD. We show that partial BACE1 genetic reduction prevents these AD-related pathological features in the Ts2 mouse model of Down syndrome. Partially reducing BACE1 by deleting one BACE1 allele blocked development of age-related endosome enlargement in the medial septal nucleus, cerebral cortex, and hippocampus and loss of choline acetyltransferase (ChAT)-positive medial septal nucleus neurons. BACE1 reduction normalized APP-βCTF elevation but did not alter Aβ40 and Aβ42 peptide levels in brain, supporting a critical role in vivo for APP-βCTF in the development of these abnormalities. Although ameliorative effects of BACE1 inhibition on β-amyloidosis and synaptic proteins levels have been previously noted in AD mouse models, our results highlight the additional potential value of BACE1 modulation in therapeutic targeting of endocytic dysfunction and cholinergic neurodegeneration in Down syndrome and AD.

  3. RESIDENCE REASONS AND LOCATION SELECTION OF WELFARE FACILITIES FOR THE ELDERLY IN BEIJING: THE IDEAL WAY TO ALLOCATE WELFARE FACILITIES FOR THE ELDERLY%北京养老服务机构入住理由及位置选择的初探——关于合理布局建设养老服务机构

    Institute of Scientific and Technical Information of China (English)

    戴维; 羚木博志; 长谷川直树

    2012-01-01

    This paper reports the residence reasons and location selection of the welfare facilities for the elderly in Beijing. First, we investigated the current situation of welfare facilities for the elderly in Beijing. Second, we executed the survey to collect the resident's characteristics and reasons for their residence. Then we analyzed the relationship between the locations of the elderly home, their children's home and the facilities. We found that the elderly would like to select the facilities near to their children. According those results, we proposed the ideal way to allocate the welfare facilities for the elderly.%通过对北京市养老服务机构的入住老人进行问卷调研,解析老人的入住理由.老人在机构选择意向中重视“离子女居住地近”的要素,并在实际选择入住时,呈现选择离子女居住地较近机构的趋势.根据该倾向,研究通过整理各功能区特征,为解决北京市养老服务机构入住率分布不均衡的现状,提出各功能区养老机构的规划建设见解.

  4. A Synchrotron-Based Facility for the in-situ Location, Chemical and Mineralogical Characterization of ~10 um Particles Captured in Aerogel

    Energy Technology Data Exchange (ETDEWEB)

    Flynn, G.; Sutton, S; Lanzirotti, A

    2009-01-01

    NASA's Stardust mission collected dust from the coma of Comet Wild-2 on January 2nd, 2004, by direct capture into aerogel cells that flew through the dust coma at 6 km/s. Stardust collected several hundred comet particles >10 {mu}m in size. These comet samples were delivered to Earth on January 15th, 2006. We developed a facility at the National Synchrotron Light Source at Brookhaven National Laboratory (Upton, NY, USA) for the in-situ characterization of 10 {mu}m particles collected in aerogel. These analytical instruments allow us to perform extensive chemical, mineralogical, and size-frequency characterization of particles captured in aerogel. These analyses are conducted without any invasive extraction, minimizing the possibility of contamination or particle loss during preparation. This facility was used to determine the chemical composition, the oxidation state, the mineralogy and to provide an indication of the grain size of the Wild-2 particles before they were removed from the aerogel. This information provides a catalog of particle types, allowing a more reasoned allocation of the particles to subsequent investigators based on a relatively detailed knowledge of the chemical composition and mineralogy of each particle. These measurements allowed a comparison of the chemical and mineralogical properties of the Wild-2 particles with other types of extraterrestrial materials, including interplanetary dust particles and meteorites. The success of in-situ analysis for Wild 2 particles demonstrates that synchrotron-based facilities will be important for the analysis of particles collected in aerogel on future earth-orbiting satellites and spacecraft.

  5. Cold Vacuum Drying Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Located near the K-Basins (see K-Basins link) in Hanford's 100 Area is a facility called the Cold Vacuum Drying Facility (CVDF).Between 2000 and 2004, workers at the...

  6. Integrated Disposal Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Located near the center of the 586-square-mile Hanford Site is the Integrated Disposal Facility, also known as the IDF.This facility is a landfill similar in concept...

  7. Environmental Toxicology Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Fully-equipped facilities for environmental toxicology researchThe Environmental Toxicology Research Facility (ETRF) located in Vicksburg, MS provides over 8,200 ft...

  8. A location-specific spreadsheet for estimating Zika risk and timing for Zika vector surveillance, using US military facilities as an example.

    Science.gov (United States)

    Foley, Desmond H; Pecor, David B

    2017-01-01

    Local Zika virus transmission in the United States involving one or both of the known vector species, Aedes aegypti and Ae. albopictus, is of major concern. To assist efforts to anticipate the risks of transmission, we developed an Excel spreadsheet tool that uses vector and virus temperature thresholds, remotely sensed maximum temperature, and habitat suitability models to answer the questions: "is Zika transmission likely here?" and "when should we conduct vector surveillance?" An example spreadsheet, updated regularly and freely available, uses near real-time and forecast temperature data to generate guidance, based on a novel four level Zika risk code, for 733 US military facilities in the 50 states, the District of Columbia, and the territories of Guam and Puerto Rico.

  9. Region 9 NPDES Facilities

    Data.gov (United States)

    U.S. Environmental Protection Agency — Point geospatial dataset representing locations of NPDES Facilities. NPDES (National Pollution Discharge Elimination System) is an EPA permit program that regulates...

  10. Geospatial Data Analysis Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Geospatial application development, location-based services, spatial modeling, and spatial analysis are examples of the many research applications that this facility...

  11. Pavement Testing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Comprehensive Environmental and Structural Analyses The ERDC Pavement Testing Facility, located on the ERDC Vicksburg campus, was originally constructed to provide...

  12. Pavement Testing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Comprehensive Environmental and Structural AnalysesThe ERDC Pavement Testing Facility, located on the ERDC Vicksburg campus, was originally constructed to provide an...

  13. An Approximation Algorithm for the Dynamic Facility Location Problem with Penalties%带惩罚的动态设施选址问题的近似算法

    Institute of Scientific and Technical Information of China (English)

    姜春艳; 徐大川

    2009-01-01

    In this paper, we study the dynamic facility location problem with penalties. In this problem, we assume that the facility cost, the service cost, and the demand and penalty of each client maybe different at each time period. At each time period, a client can be served by an opened facility or rejected by paying a penalty. We obtain the first (combinatorial) approximation algorithm with a performance factor of 1.8526 for this problem.%本文研究带惩罚的动态设施选址问题,在该问题中假设不同时段内设施的开放费用、用户的需求及连接费用可以不相同,而且允许用户的需求不被满足,但是要有惩罚.对此问题我们给出了第-个近似比为1.8526的原始对偶(组合)算法.

  14. New Limits on Nucleon Decays into Invisible Channels with the BOREXINO Counting Test Facility

    CERN Document Server

    Back, H O; De Bari, A; Beau, T; De Bellefon, A; Bellini, G; Benziger, J B; Bonetti, S; Buck, C; Caccianiga, B; Cadonati, L; Calaprice, F P; Cecchet, G; Chen, M; Di Credico, A; Dadoun, O; D'Angelo, D; Denisov, V Yu; Derbin, A V; Deutsch, M; Elisei, F; Etenko, A; Von Feilitzsch, F; Fernholz, R; Ford, R; Franco, D; Freudiger, B; Galbiati, C; Gatti, F; Gazzana, S; Giammarchi, M G; Giugni, D; Goeger-Neff, M; Goretti, A; Grieb, C; Hanger, C; Heusser, G; Ianni, A; Ianni, A M; De Kerret, H; Kiko, J; Kirsten, T; Kobychev, V V; Korga, G; Korschinek, G; Kozlov, Y; Kryn, D; Laubenstein, M; Litvinovich, E; Lendvai, C; Lombardi, P; Machulin, I; Malvezzi, S; Maneira, J; Manno, I; Manuzio, D; Manuzio, G; Masetti, F; Martemyanov, A N; Mazzucato, U; McCarty, K; Meroni, E; Miramonti, L; Monzani, M E; Musico, P; Niedermeier, L; Oberauer, L; Obolensky, M; Ortica, F; Pallavicini, M; Papp, L; Perasso, L; Pocar, A; Ponkratenko, O A; Raghavan, R S; Ranucci, G; Razeto, A; Sabelnikov, A; Salvo, C; Scardaoni, R; Schimizzi, D; Schönert, S; Simgen, H; Shutt, T A; Skorokhvatov, M; Smirnov, O Yu; Sonnenschein, A; Sotnikov, A; Sukhotin, S; Tarasenkov, V; Tartaglia, R; Testeran, G; Tretyak, V I; Vignaud, D; Vogelaar, R B; Vyrodov, V N; Wójcik, M; Zaimidoroga, O A; Zdesenko, Yu G; Zuzel, G

    2003-01-01

    The results of background measurements with the second version of the BOREXINO Counting Test Facility (CTF-II), installed in the Gran Sasso Underground Laboratory, were used to obtain limits on the instability of nucleons, bounded in nuclei, for decays into invisible channels (inv): disappearance, decays to neutrinos, etc. The approach consisted of a search for decays of unstable nuclides resulting from N and NN decays of parent ^{12}C, ^{13}C and ^{16}C nuclei in the liquid scintillator and the water shield of the CTF. Due to the extremely low background and the large mass (4.2 ton) of the CTF detector, the most stringent (or competitive) up-to-date experimental bounds have been established: \\tau(n\\to inv)>1.8\\cdot 10^{25} y, \\tau(p\\to inv)>1.1\\cdot 10^{26} y, \\tau(nn\\to inv)>4.9\\cdot 10^{25} y and \\tau(pp\\to inv)>5.0\\cdot 10^{25}y (all at 90 % C. L.).

  15. Chl12 (Ctf18) Forms a Novel Replication Factor C-Related Complex and Functions Redundantly with Rad24 in the DNA Replication Checkpoint Pathway

    OpenAIRE

    Naiki, Takahiro; Kondo, Tae; Nakada, Daisuke; Matsumoto, Kunihiro; Sugimoto, Katsunori

    2001-01-01

    RAD24 has been identified as a gene essential for the DNA damage checkpoint in budding yeast. Rad24 is structurally related to subunits of the replication factor C (RFC) complex, and forms an RFC-related complex with Rfc2, Rfc3, Rfc4, and Rfc5. The rad24Δ mutation enhances the defect of rfc5-1 in the DNA replication block checkpoint, implicating RAD24 in this checkpoint. CHL12 (also called CTF18) encodes a protein that is structurally related to the Rad24 and RFC proteins. We show here that a...

  16. 基于改进层次分析法的GIS公共服务设施选址%GIS Location of Public Service Facilities Based on Improved AHP

    Institute of Scientific and Technical Information of China (English)

    刘李霞; 毕华兴; 孔宪娟; 李宇飞; 王昆; 许华森; 鲍彪

    2011-01-01

    已有的公共服务设施选址模型较复杂且应用范围受限,无法作为通用模型出现.层次分析法可作为选址的通用模型,但单独使用层次分析法在空间分析方面仍有欠缺,单纯的GIS在复杂指标权重的处理方面存在很大不合理性.该文对层次分析法进行了改进,使之更适用于GIS的数据结构,将改进的层次分析法与GIS技术结合,成为公共服务设施选址更合理的选址模型和方法.以河北省黄骅市中学选址为例验证模型和方法的可用性.%Layout of public service facilities, which is directly related to life quality of the residents,has great influence on the construction and operation of the community. It has become an important task of the urban planning &. Management and the coordination of national and regional sustainable development Though many scholars do a lot of researches on location model of public service facilities, they cannot be a general model for their relatively complex and highly targeted. Location model using AHP has been verified. It can appear as a general location model as it's systematic,flexible,simple,and can deal with the experience of human in a scientific way. GIS as an emerging technology,whose powerful spatial analysis function makes the database location will be more systematic and efficient,and make advantages combined and inferior complementary attribute information attached to the spatial location and forms a complex structure of spatial information. However, using AHP alone is still not entirely satisfactory in the spatial analysis,and using GIS alone is especially irrational for the treatment of the weights of the impact indexes. In this paper,an improved AHP model is raised in order to be fit for GIS data structure. And then,GIS spatial a-nalysis and improved AHP model are combined in order to make a better model and method for locatioa At last, location of Huanghua middle school in Hebei is taken as an example, which shows the

  17. Effects of nearshore evaporation rates on the design of seabed gallery intake systems for SWRO facilities located along the Red Sea shoreline of Saudi Arabia

    KAUST Repository

    Dehwah, Abdullah H.A.

    2015-10-12

    Feed water to seawater reverse osmosis desalination systems should have a constant salinity with minimal variation. Intake systems that extract water from shallow nearshore areas in arid regions can exhibit significant fluctuations in salinity caused by high rates of evaporation and lack of circulation. Such fluctuations in salinity could inhibit the design, construction, and operation of seabed gallery intake systems located in shallow nearshore areas, such as the Red Sea inner shelf. Water depths range from 0 to 2 m between the beach and the edge of the fringing reef in the optimal locations for the development of seabed gallery intakes along the coast of the Red Sea of Saudi Arabia. The evaporation rate in this area is between 2 and 3 m per year. The bottom consists of mostly a marine hardground containing a thin veneer of unlithified sediment and no significant cover of corals or seagrass. The rather barren nature of the bottom suggests that periodic hypersalinity may contribute to the formation of hardgrounds on the bottom by causing supersaturation of the seawater with calcium carbonate and may limit the growth of corals and grasses. To assess the changes in salinity, a conceptual model was developed which assumes that a shallow circulation cell develops between the shoreline and deeper water offshore. Lower salinity seawater should migrate landward to replace water loss caused by evaporation with seaward moving of high-salinity water occurring along the bottom to balance the flow with ultimate mixing before the reef tract. To test this circulation pattern, a series of sensors were deployed to continuously monitor the water temperature, conductivity, and salinity at the surface and at the bottom during several periods of high air temperature. Surprisingly, the results show very little variation in salinity, despite the very high evaporation loss. The water salinity ranged between 39,000 and 40,000 mg/L with no diurnal variations of significance. Based on the

  18. Estimating Groundwater Concentrations from Mass Releases to the Aquifer at Integrated Disposal Facility and Tank Farm Locations Within the Central Plateau of the Hanford Site

    Energy Technology Data Exchange (ETDEWEB)

    Bergeron, Marcel P.; Freeman, Eugene J.

    2005-06-09

    This report summarizes groundwater-related numerical calculations that will support groundwater flow and transport analyses associated with the scheduled 2005 performance assessment of the Integrated Disposal Facility (IDF) at the Hanford Site. The report also provides potential supporting information to other ongoing Hanford Site risk analyses associated with the closure of single-shell tank farms and related actions. The IDF 2005 performance assessment analysis is using well intercept factors (WIFs), as outlined in the 2001 performance assessment of the IDF. The flow and transport analyses applied to these calculations use both a site-wide regional-scale model and a local-scale model of the area near the IDF. The regional-scale model is used to evaluate flow conditions, groundwater transport, and impacts from the IDF in the central part of the Hanford Site, at the core zone boundary around the 200 East and 200 West Areas, and along the Columbia River. The local-scale model is used to evaluate impacts from transport of contaminants to a hypothetical well 100 m downgradient from the IDF boundaries. Analyses similar to the regional-scale analysis of IDF releases are also provided at individual tank farm areas as additional information. To gain insight on how the WIF approach compares with other approaches for estimating groundwater concentrations from mass releases to the unconfined aquifer, groundwater concentrations were estimated with the WIF approach for two hypothetical release scenarios and compared with similar results using a calculational approach (the convolution approach). One release scenario evaluated with both approaches (WIF and convolution) involved a long-term source release from immobilized low-activity waste glass containing 25,550 Ci of technetium-99 near the IDF; another involved a hypothetical shorter-term release of {approx}0.7 Ci of technetium over 600 years from the S-SX tank farm area. In addition, direct simulation results for both release

  19. Allocation and Location of Transport Logistics Centres

    Directory of Open Access Journals (Sweden)

    D. Mocková

    2010-01-01

    Full Text Available The facility allocation problem sets out to determine the optimal number of facilities to be opened. Based on multiple criteria evaluation, the optimal location of the facilities is usually solved subsequently. Several considerations, e.g. technical parameters, costs and finance must be taken into account. Economic analysis is carried out on the basis of the specific instance of the problem.Let us assume that the number of potentially located facilities is known. Then the problem of the optimal location of a given number of facilities in a network is referred to as the facility location problem. The solution to the problem is a set of facilities optimally located in an area such that this area is fully covered by the required services that the facilities provide. An example of a real-life problem of this type is the location of logistics centers. 

  20. Location and logistics

    OpenAIRE

    Alumura, Sibel A.; Karab, Bahar Y.; Melo, M. Teresa

    2013-01-01

    Facility location decisions play a critical role in designing logistics networks. This article provides some guidelines on how location decisions and logistics functions can be integrated into a single mathematical model to optimize the configuration of a logistics network. This will be illustrated by two generic models, one supporting the design of a forward logistics network and the other addressing the specific requirements of a reverse logistics network. Several special cases and extensio...

  1. Location and logistics

    OpenAIRE

    Alumura, Sibel A.; Karab, Bahar Y.; Melo, M. Teresa

    2013-01-01

    Facility location decisions play a critical role in designing logistics networks. This article provides some guidelines on how location decisions and logistics functions can be integrated into a single mathematical model to optimize the configuration of a logistics network. This will be illustrated by two generic models, one supporting the design of a forward logistics network and the other addressing the specific requirements of a reverse logistics network. Several special cases and extensio...

  2. THE COMPONENT TEST FACILITY – A NATIONAL USER FACILITY FOR TESTING OF HIGH TEMPERATURE GAS-COOLED REACTOR (HTGR) COMPONENTS AND SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    David S. Duncan; Vondell J. Balls; Stephanie L. Austad

    2008-09-01

    The Next Generation Nuclear Plant (NGNP) and other High-Temperature Gas-cooled Reactor (HTGR) Projects require research, development, design, construction, and operation of a nuclear plant intended for both high-efficiency electricity production and high-temperature industrial applications, including hydrogen production. During the life cycle stages of an HTGR, plant systems, structures and components (SSCs) will be developed to support this reactor technology. To mitigate technical, schedule, and project risk associated with development of these SSCs, a large-scale test facility is required to support design verification and qualification prior to operational implementation. As a full-scale helium test facility, the Component Test facility (CTF) will provide prototype testing and qualification of heat transfer system components (e.g., Intermediate Heat Exchanger, valves, hot gas ducts), reactor internals, and hydrogen generation processing. It will perform confirmation tests for large-scale effects, validate component performance requirements, perform transient effects tests, and provide production demonstration of hydrogen and other high-temperature applications. Sponsored wholly or in part by the U.S. Department of Energy, the CTF will support NGNP and will also act as a National User Facility to support worldwide development of High-Temperature Gas-cooled Reactor technologies.

  3. Rmi1 functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1.

    Science.gov (United States)

    Lai, Mong Sing; Seki, Masayuki; Tada, Shusuke; Enomoto, Takemi

    2012-10-26

    Saccharomyces cerevisiae RecQ helicase (Sgs1) combines with DNA topoisomerase III (Top3) and RecQ-mediated genome instability 1 (Rmi1) to form an evolutionarily conserved complex that is required for processing homologous recombination intermediates and restarting collapsed replication forks. It was previously reported that Rmi1 contributes to sister chromatid cohesion; however, the underlying molecular mechanism has been unclear. In the present study, Rmi1 was found to be enriched at the region close to an early-firing replication origin when replication forks were arrested near their origins in the presence of hydroxyurea. Genetic analyses revealed that Rmi1 promoted sister chromatid cohesion in a process that was distinct from both the cohesion establishment pathway involving Ctf4, Csm3, and Chl1 and the pathway involving the acetylation of Smc3. On the other hand, Rmi1 seemed to function in a pathway involving the Ctf18-RFC complex and Mrc1, which were previously predicted to regulate leading-strand DNA replication.

  4. Location Privacy

    Science.gov (United States)

    Meng, Xiaofeng; Chen, Jidong

    With rapid development of sensor and wireless mobile devices, it is easy to access mobile users' location information anytime and anywhere. On one hand, LBS is becoming more and more valuable and important. On the other hand, location privacy issues raised by such applications have also gained more attention. However, due to the specificity of location information, traditional privacy-preserving techniques in data publishing cannot be used. In this chapter, we will introduce location privacy, and analyze the challenges of location privacy-preserving, and give a survey of existing work including the system architecture, location anonymity and query processing.

  5. Comparison of three small-break loss-of-coolant accident tests with different break locations using the system-integrated modular advanced reactor-integral test loop facility to estimate the safety of the smart design

    Directory of Open Access Journals (Sweden)

    Hwang Bae

    2017-08-01

    Full Text Available Three small-break loss-of-coolant accident (SBLOCA tests with safety injection pumps were carried out using the integral-effect test loop for SMART (System-integrated Modular Advanced ReacTor, i.e., the SMART-ITL facility. The types of break are a safety injection system line break, shutdown cooling system line break, and pressurizer safety valve line break. The thermal–hydraulic phenomena show a traditional behavior to decrease the temperature and pressure whereas the local phenomena are slightly different during the early stage of the transient after a break simulation. A safety injection using a high-pressure pump effectively cools down and recovers the inventory of a reactor coolant system. The global trends show reproducible results for an SBLOCA scenario with three different break locations. It was confirmed that the safety injection system is robustly safe enough to protect from a core uncovery.

  6. A step by step selection method for the location and the size of a waste-to-energy facility targeting the maximum output energy and minimization of gate fee.

    Science.gov (United States)

    Kyriakis, Efstathios; Psomopoulos, Constantinos; Kokkotis, Panagiotis; Bourtsalas, Athanasios; Themelis, Nikolaos

    2017-06-23

    This study attempts the development of an algorithm in order to present a step by step selection method for the location and the size of a waste-to-energy facility targeting the maximum output energy, also considering the basic obstacle which is in many cases, the gate fee. Various parameters identified and evaluated in order to formulate the proposed decision making method in the form of an algorithm. The principle simulation input is the amount of municipal solid wastes (MSW) available for incineration and along with its net calorific value are the most important factors for the feasibility of the plant. Moreover, the research is focused both on the parameters that could increase the energy production and those that affect the R1 energy efficiency factor. Estimation of the final gate fee is achieved through the economic analysis of the entire project by investigating both expenses and revenues which are expected according to the selected site and outputs of the facility. In this point, a number of commonly revenue methods were included in the algorithm. The developed algorithm has been validated using three case studies in Greece-Athens, Thessaloniki, and Central Greece, where the cities of Larisa and Volos have been selected for the application of the proposed decision making tool. These case studies were selected based on a previous publication made by two of the authors, in which these areas where examined. Results reveal that the development of a «solid» methodological approach in selecting the site and the size of waste-to-energy (WtE) facility can be feasible. However, the maximization of the energy efficiency factor R1 requires high utilization factors while the minimization of the final gate fee requires high R1 and high metals recovery from the bottom ash as well as economic exploitation of recovered raw materials if any.

  7. Small Craft Facility Locations - USACE IENC

    Data.gov (United States)

    Department of Homeland Security — These inland electronic Navigational charts (IENCs) were developed from available data used in maintenance of Navigation channels. Users of these IENCs should be...

  8. VT US EPA Regulated Facilities Point Locations

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The EnvironPollution_ENVPTS2001 data layer is based on the U.S. EPA's Envirofacts point shapefile. The data was provided to VCGI by the Vermont...

  9. Expert group formation using facility location analysis

    NARCIS (Netherlands)

    Neshati, Mahmood; Beigy, Hamid; Hiemstra, Djoerd

    2014-01-01

    In this paper, we propose an optimization framework to retrieve an optimal group of experts to perform a multi-aspect task. While a diverse set of skills are needed to perform a multi-aspect task, the group of assigned experts should be able to collectively cover all these required skills. We consid

  10. Improving Healthcare Facility Locations in Bamyan, Afghanistan

    Science.gov (United States)

    2011-12-01

    inpatient and outpatient physiotherapy for disability. District Hospital (DH) Same as CHCs, and wide range of essential drugs and laboratory services...works.bepress.com/cgi/viewcontent.cgi? article =1023&context=amy_hillier ILOG. (2004). CPLEX 9.0 Solver manual. Retrieved 23 October 2011, from...from ScienceDirect:- Computers and Operations Research: http://www.sciencedirect.com/science/ article /pii/S0305054805002959 Tan, L. J. (2009

  11. Library Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — Carnegie Library of Pittsburgh locations including address, coordinates, phone number, square footage, and standard operating hours.

  12. Hazardous Material Storage Facilities and Sites, DSHWPOPermittedUsedOilFacilities-Location in Utah of all Used Oil Facilities: Marketers, Porcessoors, Transfer, Transport and Off-specification Permitted by UDEQ Division of Hazardous Waste (DSHW) - Used Oil Section. Federal Fiscal Year 2006. Dataset Upda, Published in 2006, 1:100000 (1in=8333ft) scale, State of Utah Automated Geographic Reference Center.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Hazardous Material Storage Facilities and Sites dataset, published at 1:100000 (1in=8333ft) scale, was produced all or in part from Hardcopy Maps information...

  13. VT School Locations - K-12

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) FacilitiesSchools_PTSCHOOL is designed to provide point locations of every Vermont School along with the established school ID (PSID) for...

  14. Allegheny County Public Building Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of municipal facilities in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s...

  15. Allegheny County Public Building Locations

    Data.gov (United States)

    Allegheny County / City of Pittsburgh / Western PA Regional Data Center — This dataset contains the locations of municipal facilities in Allegheny County. If viewing this description on the Western Pennsylvania Regional Data Center’s open...

  16. Structures, Mixed Types - Oil & Gas Locations

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — An Oil and Gas Location is a DEP primary facility type related to the Oil & Gas Program. The sub-facility types related to Oil and Gas that are included in this...

  17. Underground Storage Tanks - Storage Tank Locations

    Data.gov (United States)

    NSGIC Education | GIS Inventory — A Storage Tank Location is a DEP primary facility type, and its sole sub-facility is the storage tank itself. Storage tanks are aboveground or underground, and are...

  18. 废弃物处理站选址问题的和谐搜索算法%Harmony Search Algorithm for End-of-Life Items Disposal Facilities' Location Problem

    Institute of Scientific and Technical Information of China (English)

    韩毅; 蔡建湖; 周根贵; 李延来; 宋平

    2011-01-01

    近年来,随着人们环保意识的增强和环保法规力度的加大,逆向物流逐渐受到人们的关注与重视.废弃物处理站的选址问题(end-of-life items disposal facilities'location problem,EIDFLP)是逆向物流研究领域的关键问题,该问题能否有效解决直接关系到人们的日常生活环境能否得到有效改善.针对文献中的具有多个目标的EIDFLP,首先将问题转化为单目标问题,之后采用一种新颖的和谐搜索优化算法(harmony search algorithm,HSA)对问题进行了求解.计算结果显示:1)本算法的最优解与文献中的最优解相同;2)本算法的计算时间明显少于文献中算法的计算时间;3)原文献中的一个解存在错误之处.%In recent years, with the enforcement of people's environmental protection awareness and the improvement of environmental protection regulation, more and more focuses and importance are attached on reverse logistics.End-of-life items disposal facilities' location problem (EIDFLP) is a key research direction in reverse logistics research.Whether the EIDFLP can be effectively solved is directly related to the degree of improvement on people's daily life.In this paper, for solving a multi-objective EIDFLP from literature, the multi-objective EIDFLP was transformed into a single-objective problem and then a novel harmony search algorithm (HSA) was proposed.Through the computational results,we found that the best result of HSA is the same as that in literature, the computational time is much less than that of algorithm in literature and there are some errors in a reported solution.

  19. Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1.

    Science.gov (United States)

    Farina, Andrea; Shin, Jae-Ho; Kim, Do-Hyung; Bermudez, Vladimir P; Kelman, Zvi; Seo, Yeon-Soo; Hurwitz, Jerard

    2008-07-25

    Human ChlR1 (hChlR1), a member of the DEAD/DEAH subfamily of helicases, was shown to interact with components of the cohesin complex and play a role in sister chromatid cohesion. In order to study the biochemical and biological properties of hChlR1, we purified the protein from 293 cells and demonstrated that hChlR1 possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-singlestranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity of hChlR1 is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex. We show that hChlR1 interacts with the hCtf18-RFC complex, human proliferating cell nuclear antigen, and hFen1. The interactions between Fen1 and hChlR1 stimulate the flap endonuclease activity of Fen1. Selective depletion of either hChlR1 or Fen1 by targeted small interfering RNA treatment results in the precocious separation of sister chromatids. These findings are consistent with a role of hChlR1 in the establishment of sister chromatid cohesion and suggest that its action may contribute to lagging strand processing events important in cohesion.

  20. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  1. EPA Facility Registry Service (FRS): Facility Interests Dataset - Intranet

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...

  2. EPA Facility Registry Service (FRS): Facility Interests Dataset Download

    Data.gov (United States)

    U.S. Environmental Protection Agency — This downloadable data package consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are...

  3. EPA Facility Registry Service (FRS): Facility Interests Dataset

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for all sites that are available in...

  4. Monitoring System with Two Central Facilities Protocol

    Directory of Open Access Journals (Sweden)

    Caesar Firdaus

    2017-03-01

    Full Text Available The security of data and information on government’s information system required proper way of defending against threat. Security aspect can be achieved by using cryptography algorithm, applying information hiding concept, and implementing security protocol. In this research, two central facilities protocol was implemented on Research and Development Center of Mineral and Coal Technology’s Cooperation Contract Monitoring System by utilizing AES and whitespace manipulation algorithm. Adjustment on the protocol by creating several rule of validation ID’s generation and checking processes could fulfill two of four cryptography objectives, consist of authentication and non-repudiation. The solid collaboration between central legitimization agency (CLA, central tabulating facility (CTF, and client is the main idea in two central facilities protocol. The utilization of AES algorithm could defend the data on transmission from man in the middle attack scenario. On the other hand, whitespace manipulation algorithm provided data integrity aspect of the document that is uploaded to the system itself. Both of the algorithm fulfill confidentiality, data integrity, and authentication.

  5. EPA Facility Registry Service (FRS): RADINFO

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  6. EPA Facility Registry Service (FRS): NCDB

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  7. EPA Facility Registry Service (FRS): BIA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  8. EPA Facility Registry System (FRS): NEPT

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  9. EPA Facility Registry Service (FRS): BRAC

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  10. EPA Facility Registry Service (FRS): ICIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  11. EPA Facility Registry Service (FRS): RBLC

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  12. EPA Facility Registry Service (FRS): RMP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  13. EPA Facility Registry System (FRS): NCES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  14. EPA Facility Registry Service (FRS): TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  15. EPA Facility Registry Service (FRS): NEI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  16. EPA Facility Registry Service (FRS): CAMDBS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  17. EPA Facility Registry Service (FRS): OIL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link to the Oil...

  18. EPA Facility Registry Service (FRS): SDWIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  19. Aviation Flight Support Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This facility consists of a 75' x 200' hanger with two adjacent helicopter pads located at Felker Army Airfield on Fort Eustis. A staff of Government and contractor...

  20. VT Telecommunication Facilities

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) The UtilityTelecom_TELEFAC data layer contains points which are intended to represent the location of telecommunications facilities (towers and/or...

  1. Waste Water Facilities

    Data.gov (United States)

    Vermont Center for Geographic Information — This dataset contains the locations of municipal and industrial direct discharge wastewater treatment facilities throughout the state of Vermont. Spatial data is not...

  2. Liquid Effluent Retention Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Liquid Effluent Retention Facility (LERF) is located in the central part of the Hanford Site. LERF is permitted by the State of Washington and has three liquid...

  3. Field Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Field Research Facility (FRF) located in Duck, N.C. was established in 1977 to support the U.S. Army Corps of Engineers' coastal engineering mission. The FRF is...

  4. Region 9 NPDES Facilities 2012

    Data.gov (United States)

    U.S. Environmental Protection Agency — Point geospatial dataset representing locations of NPDES Facilities. NPDES (National Pollution Discharge Elimination System) is an EPA permit program that regulates...

  5. Region 9 NPDES 2011 Facilities

    Data.gov (United States)

    U.S. Environmental Protection Agency — Point geospatial dataset representing locations of NPDES Facilities. NPDES (National Pollution Discharge Elimination System) is an EPA permit program that regulates...

  6. The dual of a generalized minimax location problem

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1992-01-01

    This paper develops the dual formulation of a generalized minimax facility location problem which has distance and linear constraints......This paper develops the dual formulation of a generalized minimax facility location problem which has distance and linear constraints...

  7. The dual of a generalized minimax location problem

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1992-01-01

    This paper develops the dual formulation of a generalized minimax facility location problem which has distance and linear constraints......This paper develops the dual formulation of a generalized minimax facility location problem which has distance and linear constraints...

  8. Status of Wakefield Monitor Experiments at the CLIC Test Facility

    CERN Document Server

    Lillestøl, Reidar; Aftab, Namra; Corsini, Roberto; Döbert, Steffen; Farabolini, Wilfrid; Grudiev, Alexej; Javeed, Sumera; Pfingstner, Juergen; Wuensch, Walter

    2016-01-01

    For the very low emittance beams in CLIC, it is vital to mitigate emittance growth which leads to reduced luminosity in the detectors. One factor that leads to emittance growth is transverse wakefields in the accelerating structures. In order to combat this the structures must be aligned with a precision of a few um. For achieving this tolerance, accelerating structures are equipped with wakefield monitors that measure higher-order dipole modes excited by the beam when offset from the structure axis. We report on such measurements, performed using prototype CLIC accelerating structures which are part of the module installed in the CLIC Test Facility 3 (CTF3) at CERN. Measurements with and without the drive beam that feeds rf power to the structures are compared. Improvements to the experimental setup are discussed, and finally remaining measurements that should be performed before the completion of the program are summarized.

  9. [The urgency of the application of the medical sanitary passport in the system for chemical safety in the areas of location of high-risk chemical facilities in the Russian Federation].

    Science.gov (United States)

    Kombarova, M Iu; Radilov, A S; Dulov, S A

    2012-01-01

    The main provisions concerning the need for a creation of medical and sanitary passport for territories in the protective measures zones (PMZ) of storage facilities and facilities for the destruction of chemical weapons (FDCW) are presented in the article. The assessment of results of certification of the territory of PMZ and FDCW in "Maradykovsky" in the Kirov region has been done.

  10. 40 CFR 265.18 - Location standards.

    Science.gov (United States)

    2010-07-01

    ... FACILITIES General Facility Standards § 265.18 Location standards. The placement of any hazardous waste in a... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Location standards. 265.18 Section 265.18 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES...

  11. EPA Facility Registry Service (FRS): ER_FRP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link to Facility...

  12. Assessment of CTF Boiling Transition and Critical Heat Flux Modeling Capabilities Using the OECD/NRC BFBT and PSBT Benchmark Databases

    Directory of Open Access Journals (Sweden)

    Maria Avramova

    2013-01-01

    Full Text Available Over the last few years, the Pennsylvania State University (PSU under the sponsorship of the US Nuclear Regulatory Commission (NRC has prepared, organized, conducted, and summarized two international benchmarks based on the NUPEC data—the OECD/NRC Full-Size Fine-Mesh Bundle Test (BFBT Benchmark and the OECD/NRC PWR Sub-Channel and Bundle Test (PSBT Benchmark. The benchmarks’ activities have been conducted in cooperation with the Nuclear Energy Agency/Organization for Economic Co-operation and Development (NEA/OECD and the Japan Nuclear Energy Safety (JNES Organization. This paper presents an application of the joint Penn State University/Technical University of Madrid (UPM version of the well-known sub-channel code COBRA-TF (Coolant Boiling in Rod Array-Two Fluid, namely, CTF, to the steady state critical power and departure from nucleate boiling (DNB exercises of the OECD/NRC BFBT and PSBT benchmarks. The goal is two-fold: firstly, to assess these models and to examine their strengths and weaknesses; and secondly, to identify the areas for improvement.

  13. Assisted Living Facilities, To identify the location of all Daycare centers in Miami-Dade County., Published in 2012, 1:600 (1in=50ft) scale, Miami-Dade County, Information Technology Department.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Assisted Living Facilities dataset, published at 1:600 (1in=50ft) scale, was produced all or in part from Other information as of 2012. It is described as 'To...

  14. Assisted Living Facilities, To identify the Adult Living facilites location within Miami-Dade County, Published in 2012, 1:2400 (1in=200ft) scale, Miami-Dade County, Information Technology Department.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Assisted Living Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Other information as of 2012. It is described as 'To...

  15. Park Facilities, This layer shows the approximate location of park and other recreational amenties in the County of Polk, Wisconsin., Published in 2007, 1:2400 (1in=200ft) scale, Polk County, Wisconsin.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Park Facilities dataset, published at 1:2400 (1in=200ft) scale, was produced all or in part from Orthoimagery information as of 2007. It is described as 'This...

  16. Biochemistry Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Biochemistry Facility provides expert services and consultation in biochemical enzyme assays and protein purification. The facility currently features 1) Liquid...

  17. Location-routing problems

    Energy Technology Data Exchange (ETDEWEB)

    Laporte, G.

    1987-01-01

    Location-routing problems involve simultaneously locating a number of facilities among candidate sites and establishing delivery routes to a set of users in such a way that the total system cost is minimized. This paper presents a survey of such problems. It includes some applications and examples of location-routing problems, a description of the main heuristics that have been developed for such problems, and reviews of various formulations and algorithms used in solving these problems. A more detailed review is given of exact algorithms for the vehicle routing problem, three-index vehicle flow formulations, and two-index vehicle flow formulations and algorithms for symmetrical and non-symmetrical problems. It is concluded that location-routing problem research is a fast-growing area, with most developments occurring over the past few years; however, research is relatively fragmented, often addresses problems which are too specific and contains several voids which have yet to be filled. A number of promising research areas are identified. 137 refs., 3 figs.

  18. Instrumentation for Longitudinal Beam Gymnastics in FEL's and at the CLIC Test Facility 3

    CERN Document Server

    Lefèvre, T; Bravin, E; Burger, S; Corsini, R; Döbert, S; Soby, L; Tecker, F A; Urschutz, P; Welsch, C P; Alesini, D; Biscari, C; Buonomo, B; Coiro, O; Ghigo, A; Marcellini, F; Preger, B; Dabrowski, A; Velasco, M; Craievich, P; Ferianis, M; Veronese, M; Ferrari, A

    2008-01-01

    Built at CERN by an international collaboration, the CLIC Test Facility 3 (CTF3) aims at demonstrating the feasibility of a high luminosity 3 TeV e+-e- collider by the year 2010. One of the main issues to be demonstrated is the generation of a high average current (30 A) high frequency (12 GHz) bunched beam by means of RF manipulation. At the same time, Free Electron Lasers (FEL) are developed in several places all over the world with the aim of providing high brilliance photon sources. These machines rely on the production of high peak current electron bunches. The required performances put high demands on the diagnostic equipment and innovative longitudinal monitors have been developed during the past years. This paper gives an overview of the longitudinal instrumentation developed at ELETTRA and CTF3, where a special effort was made in order to implement at the same time non-intercepting devices for online monitoring, and destructive diagnostics which have the advantage of providing more detailed informati...

  19. Locating a circle on a sphere

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2007-01-01

    We consider the problem of locating a spherical circle with respect to existing facilities on a sphere, such that the sum of distances between the circle and the facilities is minimized or such that the maximum distance is minimized. The problem properties are analyzed, and we give solution...... procedures. When the circle to be located is restricted to be a great circle, some simplifications are possible. The models may be used in preliminary studies on the location of large linear facilities on the earth's surface, such as superhighways, pipelines, and transmission lines, or in totally different...

  20. Location Based Services and Applications

    Directory of Open Access Journals (Sweden)

    Elenis Gorrita Michel

    2012-05-01

    Full Text Available Location Based Services (LBS continue to grow in popularity, effectiveness and reliability, to the extent that applications are designed and implemented taking into account the facilities of the user location information. In this work, some of the main applications are addressed, in order to make an assessment of the current importance of the LBS, as a branch of technology in full swing. In addition, the main techniques for location estimation are studied, essential information to the LBS. Because of this it is a highly topical issue, the ongoing works and researches are also discussed.

  1. FRS (Facility Registration System) Sites, Geographic NAD83, EPA (2007) [facility_registration_system_sites_LA_EPA_2007

    Data.gov (United States)

    Louisiana Geographic Information Center — This dataset contains locations of Facility Registry System (FRS) sites which were pulled from a centrally managed database that identifies facilities, sites or...

  2. 30 CFR 816.181 - Support facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Support facilities. 816.181 Section 816.181... § 816.181 Support facilities. (a) Support facilities shall be operated in accordance with a permit... results. (b) In addition to the other provisions of this part, support facilities shall be located...

  3. 30 CFR 57.20008 - Toilet facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Toilet facilities. 57.20008 Section 57.20008....20008 Toilet facilities. (a) Toilet facilities shall be provided at locations that are compatible with the mine operations and that are readily accessible to mine personnel. (b) The facilities shall be...

  4. 30 CFR 56.20008 - Toilet facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Toilet facilities. 56.20008 Section 56.20008... Toilet facilities. (a) Toilet facilities shall be provided at locations that are compatible with the mine operations and that are readily accessible to mine personnel. (b) The facilities shall be kept clean and...

  5. 30 CFR 817.181 - Support facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Support facilities. 817.181 Section 817.181... ACTIVITIES § 817.181 Support facilities. (a) Support facilities shall be operated in accordance with a permit.... (b) In addition to the other provisions of this part, support facilities shall be located, maintained...

  6. Hazardous Material Storage Facilities and Sites - WASTE_DISPOSAL_STORAGE_HANDLING_IDEM_IN: Waste Site Locations for Disposal, Storage and Handling of Solid Waste and Hazardous Waste in Indiana (Indiana Department of Environmental Management, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — WASTE_DISPOSAL_STORAGE_HANDLING_IDEM_IN is a point shapefile that contains waste site locations for the disposal, storage, and handling of solid and hazardous waste...

  7. Fabrication Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Fabrication Facilities are a direct result of years of testing support. Through years of experience, the three fabrication facilities (Fort Hood, Fort Lewis, and...

  8. Facility Microgrids

    Energy Technology Data Exchange (ETDEWEB)

    Ye, Z.; Walling, R.; Miller, N.; Du, P.; Nelson, K.

    2005-05-01

    Microgrids are receiving a considerable interest from the power industry, partly because their business and technical structure shows promise as a means of taking full advantage of distributed generation. This report investigates three issues associated with facility microgrids: (1) Multiple-distributed generation facility microgrids' unintentional islanding protection, (2) Facility microgrids' response to bulk grid disturbances, and (3) Facility microgrids' intentional islanding.

  9. Assisted Living Facilities - CARE_LONG_TERM_FACILITIES_ISDH_IN: Residential Care Facilities, Nursing Homes, and Hospices in Indiana in 2007 (Indiana State Department of Health, Point Shapefile)

    Data.gov (United States)

    NSGIC State | GIS Inventory — CARE_LONG_TERM_FACILITIES_ISDH_IN is a point shapefile showing the locations of 86 residential care facilities, 525 long-term care facilities (nursing homes), and 81...

  10. Assisted Living Facilities - CARE_LONG_TERM_FACILITIES_ISDH_IN: Residential Care Facilities, Nursing Homes, and Hospices in Indiana in 2007 (Indiana State Department of Health, Point Shapefile)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — CARE_LONG_TERM_FACILITIES_ISDH_IN is a point shapefile showing the locations of 86 residential care facilities, 525 long-term care facilities (nursing homes), and...

  11. Proton beam therapy facility

    Energy Technology Data Exchange (ETDEWEB)

    1984-10-09

    It is proposed to build a regional outpatient medical clinic at the Fermi National Accelerator Laboratory (Fermilab), Batavia, Illinois, to exploit the unique therapeutic characteristics of high energy proton beams. The Fermilab location for a proton therapy facility (PTF) is being chosen for reasons ranging from lower total construction and operating costs and the availability of sophisticated technical support to a location with good access to patients from the Chicago area and from the entire nation. 9 refs., 4 figs., 26 tabs.

  12. Lake Beach Monitoring Locations in Iowa

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — Monitored state lake beach locations in Iowa. The Watershed Monitoring & Assessment Section of the Iowa DNR takes regular water samples at these listed beaches...

  13. VT School Locations - Post-Secondary

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) FacilitiesSchools_PTSCHOOL is designed to provide point locations of every Vermont School along with the established school ID (PSID) for...

  14. EPA Facility Registry Service (FRS): LANDFILL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of non-hazardous waste...

  15. EPA Facility Registry Service (FRS): ACRES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service consists of location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of sites that link to...

  16. Natural Gas Storage Facilities, US, 2010, Platts

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Platts Natural Gas Storage Facilities geospatial data layer contains points that represent locations of facilities used for natural gas storage in the United...

  17. Stockbridge Antenna Measurement and Research Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Stockbridge Antenna Measurement Facility is located 23 miles southwest of AFRL¹s Rome Research Site. This unique measurement facility is designed to evaluate the...

  18. EPA Facility Registry Service (FRS): RCRA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of hazardous waste...

  19. Properties of 3-dimensional line location models

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2002-01-01

    We consider the problem of locating a line with respect to some existing facilities in 3-dimensional space, such that the sum of weighted distances between the line and the facilities is minimized. Measuring distance using the l\\_p norm is discussed, along with the special cases of Euclidean...

  20. Properties of 3-dimensional line location models

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2002-01-01

    We consider the problem of locating a line with respect to some existing facilities in 3-dimensional space, such that the sum of weighted distances between the line and the facilities is minimized. Measuring distance using the l\\_p norm is discussed, along with the special cases of Euclidean...

  1. Locating a circle on a sphere

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2003-01-01

    We consider the problem of locating a spherical circle with respect to existing facilities on a sphere, such that the sum of weighted distances between the circle and the facilities is minimized, or such that the maximum weighted distance is minimized. The problem properties are analyzed, and we ...

  2. Locating a circle on a sphere

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2007-01-01

    We consider the problem of locating a spherical circle with respect to existing facilities on a sphere, such that the sum of distances between the circle and the facilities is minimized or such that the maximum distance is minimized. The problem properties are analyzed, and we give solution proce...

  3. A note on fixed point optimality criteria for the location problem with arbitrary norms: Reply

    DEFF Research Database (Denmark)

    Juel, Henrik; Love, Robert F.

    1983-01-01

    The single-facility location problem in continuous space is considered, with distances given by arbitrary norms. When distances are Euclidean, for many practical problems the optimal location of the new facility coincides with one of the existing facilities. This property carries over to problems...... with generalized distances. In this paper a necessary and sufficient condition for the location of an existing facility to be the optimal location of the new facility is developed. Some computational examples using the condition are given....

  4. Locating a circle on the plane using the minimax criterion

    OpenAIRE

    2006-01-01

    We consider the problem of locating a circle with respect to existing facilities on the plane, such that the largest weighted distance between the circle and the facilities is minimized. The problem properties are analyzed, and a solution procedure proposed.

  5. Locating a circle on the plane using the minimax criterion

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schoebel, Anita

    2006-01-01

    We consider the problem of locating a circle with respect to existing facilities on the plane, such that the largest weighted distance between the circle and the facilities is minimized. The problem properties are analyzed, and a solution procedure proposed.......We consider the problem of locating a circle with respect to existing facilities on the plane, such that the largest weighted distance between the circle and the facilities is minimized. The problem properties are analyzed, and a solution procedure proposed....

  6. EPA Facility Registry Service (FRS): CERCLIS_NPL

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that are...

  7. EPA Facility Registry Service (FRS): ER_CERCLIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  8. EPA Facility Registry Service (FRS): ER_RMP

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  9. EPA Facility Registry Service (FRS): AIRS_AFS_MAJOR

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  10. EPA Facility Registry Service (FRS): ER_RCRATSD

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  11. EPA Facility Registry Service (FRS): AIRS_AQS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  12. EPA Facility Registry Service (FRS): PCS_NPDES

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  13. EPA Facility Registry Service (FRS): PCS_NPDES_MAJOR

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that are...

  14. EPA Facility Registry Service (FRS): RCRA_LQG

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  15. EPA Facility Registry Service (FRS): AIRS_AFS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  16. EPA Facility Registry Service (FRS): ER_TSCA

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  17. EPA Facility Registry Service (FRS): ER_TRI

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  18. EPA Facility Registry Service (FRS): RCRA_TRANS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry Service (FRS) for the subset of facilities that link...

  19. EPA Facility Registry Service (FRS): ER_EPLAN

    Data.gov (United States)

    U.S. Environmental Protection Agency — This web feature service contains location and facility identification information from EPA's Facility Registry System (FRS) for the subset of facilities that link...

  20. Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

    Science.gov (United States)

    Khair, Lyne; Chang, Ya-Ting; Subramanian, Lakxmi; Russell, Paul; Nakamura, Toru M

    2010-06-01

    While telomeres must provide mechanisms to prevent DNA repair and DNA damage checkpoint factors from fusing chromosome ends and causing permanent cell cycle arrest, these factors associate with functional telomeres and play critical roles in the maintenance of telomeres. Previous studies have established that Tel1 (ATM) and Rad3 (ATR) kinases play redundant but essential roles for telomere maintenance in fission yeast. In addition, the Rad9-Rad1-Hus1 (911) and Rad17-RFC complexes work downstream of Rad3 (ATR) in fission yeast telomere maintenance. Here, we investigated how 911, Rad17-RFC and another RFC-like complex Ctf18-RFC contribute to telomere maintenance in fission yeast cells lacking Tel1 and carrying a novel hypomorphic allele of rad3 (DBD-rad3), generated by the fusion between the DNA binding domain (DBD) of the fission yeast telomere capping protein Pot1 and Rad3. Our investigations have uncovered a surprising redundancy for Rad9 and Hus1 in allowing Rad1 to contribute to telomere maintenance in DBD-rad3 tel1 cells. In addition, we found that Rad17-RFC and Ctf18-RFC carry out redundant telomere maintenance functions in DBD-rad3 tel1 cells. Since checkpoint sensor proteins are highly conserved, genetic redundancies uncovered here may be relevant to telomere maintenance and detection of DNA damage in other eukaryotes.

  1. Elevated Fixed Platform Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Elevated Fixed Platform (EFP) is a helicopter recovery test facility located at Lakehurst, NJ. It consists of a 60 by 85 foot steel and concrete deck built atop...

  2. Environmental Protection Agency (EPA) Facilities

    Data.gov (United States)

    Department of Homeland Security — This SEGS layer shows the names, locations and biographical information of EPA facilities in the U.S. and its territories. Included in this layer are headquarters...

  3. Freshwater Treatment and Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Freshwater Treatment and Test Facility, located at SANGB, has direct year-round access to water from Lake St. Clair and has a State of Michigan approved National...

  4. 基于邻域设施的中国大城市网络店铺的区位取向——以上海、深圳、天津、北京四城市为例%Location Orientation of E-shops in China's Major Cities Based on Neighborhood Facilities:Case Studies of Shanghai, Shenzhen, Tianjin and Beijing

    Institute of Scientific and Technical Information of China (English)

    路紫; 李晓楠; 杨丽花; 杨东; 邓丽丽

    2011-01-01

    This paper employs two basic approaches: fuzzy location-orientation method based on neighborhood facilities and fuzzy multiple attribute decision making (MADM) method. The study focuses on spatial agglomeration analysis of e-shops which have tangible stores at Taobao website. The Taobao e-shops located in Beijing, Shanghai, Shenzhen and Tianjin have six categories of goods: digital products, household collections, clothing, skin care, stationery and sports. These e-shops can be divided into four location types: complete, overlapping, transitional and partial. Based on these four types, this paper reveals the biased characteristics of location-orientation of various e-shops and the changes of location orientation influence factors in information era, and further explores the optimal location choices of digital product e-shops which have obvious location distribution. The research findings are as follows. (1) Different goods categories have significant differences on e-services network location choice (ESNLC),and decentralization and agglomeration coexist. Agglomeration only happens at precious commodities such as digital categories and it still relies on traditional neighborhood facilities.By contrast, the majority of ordinary commodity e-shops barely have overlapping location layout, and have already shown a new location-oriented regular pattern, which no longer follows the traditional location theory. (2) The e-services network location choices under different commercial models differ from each other. The influences on ESNLC of c2c e-commerce model tend to be more different from the traditional location choice, which indicates that c2c e-commerce is the foundation of changes of location-orientation influence factors of e-shops. In addition to the old transmission network, sources of supply, market concentration factors, skilled labor factors and trust factors would become the mainstream. (3) Triangular fuzzy numbers can be used to calculate the optimal location of

  5. Thermal Radiation Source Test Facility,

    Science.gov (United States)

    1984-01-01

    KEY WORDS (Continu on revers side I eesr and identify by block nuMb.,) Thermal Radiation Source Thermal Test Facility 20 ABSTRACT (Continue on reverse...SECTION 1 INTRODUCTION 1-1 GENERAL Defense Nuclear Agency’s Field Command, located at Kirtland AFB in New Mexico, has recently upgraded its thermal test facility...is used to evaluate damage and survivability in a nuclear environment. The thermal test facility was first established in 1979 and used O large

  6. Regulatory facility guide for Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.S.; Bock, R.E.; Francis, M.W.; Gove, R.M.; Johnson, P.E.; Kovac, F.M.; Mynatt, J.O. [Oak Ridge National Lab., TN (United States); Rymer, A.C. [Transportation Consulting Services, Knoxville, TN (United States)

    1994-02-28

    The Regulatory Facility Guide (RFG) has been developed for the DOE and contractor facilities located in the state of Ohio. It provides detailed compilations of international, federal, and state transportation-related regulations applicable to shipments originating at destined to Ohio facilities. This RFG was developed as an additional resource tool for use both by traffic managers who must ensure that transportation operations are in full compliance with all applicable regulatory requirements and by oversight personnel who must verify compliance activities.

  7. EPA Facility Registry Service (FRS): CERCLIS

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data provides location and attribute information on Facilities regulated under the Comprehensive Environmental Responsibility Compensation and Liability...

  8. New experimental limits on violations of the Pauli exclusion principle obtained with the Borexino Counting Test Facility

    CERN Document Server

    Back, H O; De Bari, A; De Bellefon, A; Bellini, G; Benziger, J; Bonetti, S; Buck, C; Caccianiga, B; Cadonati, L; Calaprice, F; Cecchet, G; Chen, M; Di Credico, A; Dadoun, O; D'Angelo, D; Derbin, A; Deutsch, M; Etenko, A; Von Feilitzsch, F; Fernholz, R; Ford, R; Franco, D; Freudiger, B; Galbiati, C; Gazzana, S; Giammarchi, M G; Goeger-Neff, M; Goretti, A; Grieb, C; Hampel, W; Harding, E; Hartmann, F X; Heusser, G; Ianni, A; Ianni, A M; De Kerret, H; Kiko, J; Kirsten, T; Kobychev, V V; Korga, G; Korschinek, G; Kozlov, Y; Kryn, D; Laubenstein, M; Lendvai, C; Leung, M; Litvinovich, E; Lombardi, P; Machulin, I; Malvezzi, S; Maneira, J; Manno, I; Manuzio, D; Manuzio, G; Masetti, F; Martemianov, A; Mazzucato, U; McCarty, K; Meroni, E; Mention, G; Miramonti, L; Monzani, M E; Muratova, V; Musico, P; Niedermeier, L; Oberauer, L; Obolensky, M; Ortica, F; Pallavicini, M; Papp, L; Perasso, L; Peiffer, P; Pocar, A; Raghavan, R S; Ranucci, G; Razeto, A; Sabelnikov, A; Salvo, C; Scardaoni, R; Schimizzi, D; Schönert, S; Simgen, H; Shutt, T A; Skorokhvatov, M; Smirnov, O; Sonnenschein, A; Sotnikov, A; Sukhotin, S; Suvorov, Y; Tarasenkov, V; Tartaglia, R; Testera, G; Vignaud, D; Vogelaar, R B; Vyrodov, V N; Wójcik, M; Zaimidoroga, O A; Zuzel, G

    2004-01-01

    The Pauli exclusion principle (PEP) has been tested for nucleons ($n,p$) in $^{12}C$ and $^{16}O$ nuclei, using the results of background measurements with the prototype of the Borexino detector, the Counting Test Facility (CTF). The approach consisted of a search for $\\gamma$, $n$, $p$ and/or $\\alpha$'s emitted in a non-Paulian transition of 1$P$- shell nucleons to the filled 1$S_{1/2}$ shell in nuclei. Similarly, the Pauli-forbidden $\\beta^{\\pm}$ decay processes were searched for. Due to the extremely low background and the large mass (4.2 tons) of the CTF detector, the following most stringent up-to-date experimental bounds on PEP violating transitions of nucleons have been established: $\\tau(^{12}C\\to^{12}\\widetilde{C}+\\gamma) > 2.1\\cdot10^{27}$ y, $\\tau(^{12}C\\to^{11}\\widetilde{B}+ p) > 5.0\\cdot10^{26}$ y, $\\tau(^{12}C(^{16}O)\\to^{11}\\widetilde{C}(^{15}\\widetilde{O})+ n) > 3.7 \\cdot 10^{26}$ y, $\\tau(^{12}C\\to^{8}\\widetilde{Be}+\\alpha) > 6.1 \\cdot 10^{23}$ y, $\\tau(^{12}C\\to^{12}\\widetilde{N}+ e^- + \\wid...

  9. Performance of Parabolic and Diffusive OTR Screens at the CLIC Test Facility 3

    CERN Document Server

    Olvegaard, M; Bravin, E; Burger, S; Dabrowski, A; Lefevre, T; Welsch, C P

    2011-01-01

    At the CLIC Test Facility 3, OTR screens are commonly used in beam imaging systems for energy and energy spread characterization in dedicated spectrometer lines. In these lines the horizontal beam size is typically of the order of one centimeter. Already in 2005 a limitation was observed resulting from a strong dependence of the intensity of the light captured by the camera, on the position on the screen (vignetting). The severity of this effect increases with the electron energy, as the aperture of the optical system is finite and the OTR photons are emitted in a small cone of 1/γ angle. To mitigate this effect, different shapes and surface polishing of the screens were investigated. Parabolic and diffusive OTR radiators were tested in several spectrometer lines all along the CTF3 complex. The results are presented in this paper.

  10. Measuring the bunch frequency multiplication at the 3rd CLIC Test Facility

    CERN Document Server

    Dabrowski, AE; Bravin, E; Corsini, R; Dobert, S; Lefevre, T; Rabiller, A; Soby, L; Skowronski, P K; Tecker, F; Egger, D; Ferrari, A; Welsch, C P

    2012-01-01

    The CLIC Test Facility 3 (CTF3) is being built and commissioned by an international collaboration to test the feasibility of the proposed Compact Linear Collider (CLIC) drive beam generation scheme. Central to this scheme is the use of RF deflectors to inject bunches into a delay loop and a combiner ring, in order to transform the initial bunch frequency of 1.5 GHz from the linac to a final bunch frequency of 12 GHz. To do so, the machine's transverse optics must be tuned to ensure beam isochronicity and each ring's length can finally be adjusted with wiggler magnets to a sub millimeter path length accuracy. Diagnostics based on optical streak camera and RF power measurements, in particular frequency bands, have been designed to measure the longitudinal behaviour of the beam during the combination. This paper presents the diagnostics and recent commissioning measurements.

  11. Pressure Transducer Locations

    Data.gov (United States)

    National Aeronautics and Space Administration — Files are located here, defining the locations of the pressure transducers on the HIRENASD model. These locations also correspond to the locations that analysts...

  12. 44 CFR 206.226 - Restoration of damaged facilities.

    Science.gov (United States)

    2010-10-01

    ... funding for and require restoration of a destroyed facility at a new location when: (i) The facility is... facilities. 206.226 Section 206.226 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... § 206.226 Restoration of damaged facilities. Work to restore eligible facilities on the basis of...

  13. Dry Well Storage Facility conceptual design study

    Energy Technology Data Exchange (ETDEWEB)

    1979-02-01

    The Dry Well Storage Facility described is assumed to be located adjacent to or near a Spent Fuel Receiving and Packaging Facility and/or a Packaged Fuel Transfer Facility. Performance requirements, quality levels and codes and standards, schedule and methods of performance, special requirements, quality assurance program, and cost estimate are discussed. Appendices on major mechanical equipment and electric power requirements are included.

  14. 21 CFR 1271.190 - Facilities.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Facilities. 1271.190 Section 1271.190 Food and... CELLULAR AND TISSUE-BASED PRODUCTS Current Good Tissue Practice § 1271.190 Facilities. (a) General. Any facility used in the manufacture of HCT/Ps must be of suitable size, construction, and location to prevent...

  15. 20 CFR 404.1623 - Facilities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Facilities. 404.1623 Section 404.1623...- ) Determinations of Disability Administrative Responsibilities and Requirements § 404.1623 Facilities. (a) Space... determinations. (b) Location of facilities. Subject to appropriate Federal funding, the State will determine the...

  16. 20 CFR 416.1023 - Facilities.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Facilities. 416.1023 Section 416.1023... Facilities. (a) Space, equipment, supplies, and other services. Subject to appropriate Federal funding, the... and prompt disability determinations. (b) Location of facilities. Subject to appropriate Federal...

  17. Mammography Facilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Mammography Facility Database is updated periodically based on information received from the four FDA-approved accreditation bodies: the American College of...

  18. Health Facilities

    Science.gov (United States)

    Health facilities are places that provide health care. They include hospitals, clinics, outpatient care centers, and specialized care centers, such as birthing centers and psychiatric care centers. When you ...

  19. Canyon Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — B Plant, T Plant, U Plant, PUREX, and REDOX (see their links) are the five facilities at Hanford where the original objective was plutonium removal from the uranium...

  20. ANTARES: Cold neutron radiography and tomography facility

    OpenAIRE

    Schulz, Michael; Schillinger, Burkhard

    2015-01-01

    The neutron imaging facility ANTARES, operated by the Technische Universität München, is located at the cold neutron beam port SR-4a. Based on a pinhole camera principle with a variable collimator located close to the beam port, the facility provides the possibility for flexible use in high resolution and high flux imaging.

  1. Mineral facilities of Europe

    Science.gov (United States)

    Almanzar, Francisco; Baker, Michael S.; Elias, Nurudeen; Guzman, Eric

    2010-01-01

    This map displays over 1,700 records of mineral facilities within the countries of Europe and western Eurasia. Each record represents one commodity and one facility type at a single geographic location. Facility types include mines, oil and gas fields, and plants, such as refineries, smelters, and mills. Common commodities of interest include aluminum, cement, coal, copper, gold, iron and steel, lead, nickel, petroleum, salt, silver, and zinc. Records include attributes, such as commodity, country, location, company name, facility type and capacity (if applicable), and latitude and longitude geographical coordinates (in both degrees-minutes-seconds and decimal degrees). The data shown on this map and in table 1 were compiled from multiple sources, including (1) the most recently available data from the U.S. Geological Survey (USGS) Minerals Yearbook (Europe and Central Eurasia volume), (2) mineral statistics and information from the USGS Minerals Information Web site (http://minerals.usgs.gov/minerals/pubs/country/europe.html), and (3) data collected by the USGS minerals information country specialists from sources, such as statistical publications of individual countries, annual reports and press releases of operating companies, and trade journals. Data reflect the most recently published table of industry structure for each country at the time of this publication. Additional information is available from the country specialists listed in table 2.

  2. Accessibility, activity participation and location of activities

    DEFF Research Database (Denmark)

    Næss, Petter

    2006-01-01

    By investigating relationships between residential location and the availability of facilities, location of activities, trip distances, activity participation and trip frequencies, this paper seeks to contribute to a more detailed and nuanced understanding of the relationships between residential...... outweigh each other. However, differences in trip distances due to the location of the dwelling relative to concentrations of facilities translate into substantially longer total travelling distances among suburbanites than among inner-city residents....... location and the amount of daily-life travel in an urban region. The empirical data are from a comprehensive study of residential location and travel in Copenhagen Metropolitan Area. Differences between inner- and outer-area residents in activity frequencies and trip frequencies are modest and partly...

  3. Wi-Fi real time location systems

    Science.gov (United States)

    Doll, Benjamin A.

    This thesis objective was to determine the viability of utilizing an untrained Wi-Fi. real time location system as a GPS alternative for indoor environments. Background. research showed that GPS is rarely able to penetrate buildings to provide reliable. location data. The benefit of having location information in a facility and how they might. be used for disaster or emergency relief personnel and their resources motivated this. research. A building was selected with a well-deployed Wi-Fi infrastructure and its. untrained location feature was used to determine the distance between the specified. test points and the system identified location. It was found that the average distance. from the test point throughout the facility was 14.3 feet 80% of the time. This fell within. the defined viable range and supported that an untrained Wi-Fi RTLS system could be a. viable solution for GPS's lack of availability indoors.

  4. 42 CFR 456.605 - Number and location of teams.

    Science.gov (United States)

    2010-10-01

    ... Facilities and Institutions for Mental Diseases § 456.605 Number and location of teams. There must be a... 42 Public Health 4 2010-10-01 2010-10-01 false Number and location of teams. 456.605 Section 456... intervals in each facility caring for recipients....

  5. A Location Privacy Aware Friend Locator

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Thomsen, Jeppe Rishede; Saltenis, Simonas

    2009-01-01

    to trade their location privacy for quality of service, limiting the attractiveness of the services. The challenge is to develop a communication-efficient solution such that (i) it detects proximity between a user and the user’s friends, (ii) any other party is not allowed to infer the location of the user...

  6. Locating a minisum circle in the plane

    DEFF Research Database (Denmark)

    Brimberg, Jack; Juel, Henrik; Schöbel, Anita

    2009-01-01

    We consider the problem of locating a circle with respect to existing facilities in the plane such that the sum of weighted distances between the circle and the facilities is minimized, i.e., we approximate a set of given points by a circle regarding the sum of weighted distances. If the radius...... of the circle is a variable we show that there always exists an optimal circle passing through two of the existing facilities. For the case of a fixed radius we provide characterizations of optimal circles in special cases. Solution procedures are suggested....

  7. New Location Improves Efficiency | Poster

    Science.gov (United States)

    By Nancy Parrish, Staff Writer The physical proximity of the SAIC-Frederick Intellectual Property (IP) Office to the NCI Technology Transfer Center (NCI-TTC) is one of the many benefits of being at the Advanced Technology Research Facility (ATRF), according to Courtney Silverthorn, Ph.D. Being in one location “has increased the effectiveness of both informal communication and formal meetings. We have already brainstormed solutions for several issues in the hallway during an informal chat,” said Silverthorn, an SAIC-Frederick IP specialist.

  8. Accessibility, activity participation and location of activities

    DEFF Research Database (Denmark)

    Næss, Petter

    2006-01-01

    By investigating relationships between residential location and the availability of facilities, location of activities, trip distances, activity participation and trip frequencies, this paper seeks to contribute to a more detailed and nuanced understanding of the relationships between residential...... location and the amount of daily-life travel in an urban region. The empirical data are from a comprehensive study of residential location and travel in Copenhagen Metropolitan Area. Differences between inner- and outer-area residents in activity frequencies and trip frequencies are modest and partly...

  9. Locative Inversion in Cantonese.

    Science.gov (United States)

    Mok, Sui-Sang

    This study investigates the phenomenon of "Locative Inversion" in Cantonese. The term "Locative Inversion" indicates that the locative phrase (LP) syntactic process in Cantonese and the appears at the sentence-initial position and its logical subject occurs postverbally. It is demonstrated that this Locative Inversion is a…

  10. Asian Facilities

    Science.gov (United States)

    Nakahata, M.

    2011-04-01

    Asian underground facilities are reviewed. The YangYang underground Laboratory in Korea and the Kamioka observatory in Japan are operational and several astrophysical experiments are running. Indian Neutrino Observatory(INO) and China JinPing Underground Laboratory (CJPL) are under construction and underground experiments are being prepared. Current activities and future prospects at those underground sites are described.

  11. Budget estimates: Fiscal year 1994. Volume 2: Construction of facilities

    Science.gov (United States)

    1994-01-01

    The Construction of Facilities (CoF) appropriation provides contractual services for the repair, rehabilitation, and modification of existing facilities; the construction of new facilities and the acquisition of related collateral equipment; the acquisition or condemnation of real property; environmental compliance and restoration activities; the design of facilities projects; and advanced planning related to future facilities needs. Fiscal year 1994 budget estimates are broken down according to facility location of project and by purpose.

  12. Bottling plant location of microbreweries in East Midlands area, UK

    OpenAIRE

    Zheng, Chi

    2013-01-01

    Facility location decisions are critical in real-life projects, which impact on profitability of investment and service levels from demand side. In this paper, a project-based facility location problem should be resolved which refers to the establishment of a centralized bottling plant to serve microbreweries in East Midlands area of UK. This problem will be structured by firstly finding a mathematically theoretical location using the centre-of-gravity method and then formulate the problem as...

  13. Subsurface Facility System Description Document

    Energy Technology Data Exchange (ETDEWEB)

    Eric Loros

    2001-07-31

    The Subsurface Facility System encompasses the location, arrangement, size, and spacing of the underground openings. This subsurface system includes accesses, alcoves, and drifts. This system provides access to the underground, provides for the emplacement of waste packages, provides openings to allow safe and secure work conditions, and interfaces with the natural barrier. This system includes what is now the Exploratory Studies Facility. The Subsurface Facility System physical location and general arrangement help support the long-term waste isolation objectives of the repository. The Subsurface Facility System locates the repository openings away from main traces of major faults, away from exposure to erosion, above the probable maximum flood elevation, and above the water table. The general arrangement, size, and spacing of the emplacement drifts support disposal of the entire inventory of waste packages based on the emplacement strategy. The Subsurface Facility System provides access ramps to safely facilitate development and emplacement operations. The Subsurface Facility System supports the development and emplacement operations by providing subsurface space for such systems as ventilation, utilities, safety, monitoring, and transportation.

  14. Canastota Renewable Energy Facility Project

    Energy Technology Data Exchange (ETDEWEB)

    Blake, Jillian; Hunt, Allen

    2013-12-13

    The project was implemented at the Madison County Landfill located in the Town of Lincoln, Madison County, New York. Madison County has owned and operated the solid waste and recycling facilities at the Buyea Road site since 1974. At the onset of the project, the County owned and operated facilities there to include three separate landfills, a residential solid waste disposal and recycled material drop-off facility, a recycling facility and associated administrative, support and environmental control facilities. This putrescible waste undergoes anaerobic decomposition within the waste mass and generates landfill gas, which is approximately 50% methane. In order to recover this gas, the landfill was equipped with gas collection systems on both the east and west sides of Buyea Road which bring the gas to a central point for destruction. In order to derive a beneficial use from the collected landfill gases, the County decided to issue a Request for Proposals (RFP) for the future use of the generated gas.

  15. Design of the 15 GHz BPM test bench for the CLIC test facility to perform precise stretchedwire RF measurements

    CERN Document Server

    Silvia Zorzetti, Silvia; Galindo Muño, Natalia; Wendt, Manfred

    2015-01-01

    The Compact Linear Collider (CLIC) requires a low emittance beam transport and preservation, thus a precise control of the beam orbit along up to 50 km of the accelerator components in the sub-m regime is required. Within the PACMAN3 (Particle Accelerator Components Metrology and Alignment to the Nanometer Scale) PhD training action a study with the objective of pre-aligning the electrical centre of a 15 GHz cavity beam position monitor (BPM) to the magnetic centre of the main beam quadrupole is initiated. Of particular importance is the design of a specific test bench to study the stretched-wire setup for the CLIC Test Facility (CTF3) BPM, focusing on the aspects of microwave signal excitation, transmission and impedance-matching, as well as the mechanical setup and reproducibility of the measurement method.

  16. Cryogenic performance and numerical modeling of a helium refrigerator for the JT-60SA coil test facility

    Science.gov (United States)

    Serrand, Alexandre; Abdel-Maksoud, Walid; Genini, Laurent; Juster, François-Paul

    2014-01-01

    In the framework of the JT-60SA project, a cryogenic loop, dedicated to the tests of the JT-60SA Toroidal Field Coils, is planned to be installed at CEA Saclay. To analyze the dynamic thermal behavior of the cryogenic loop and to optimize the cryogenic process control of the coil test facility, dynamic simulations will be carried out with the software EcosimPro. This paper deals with the validation of the software. Experimental power measurements in pure refrigeration on a helium refrigerator have been compared to computations. Results are close and allow validating the software. The modeling of the JT-60SA CTF cryogenic test loop is also described in order to give an overview of the next computations.

  17. Geographic Accessibility - Providing government servies in an spatially equitable manner: Perspectives for Fire Station location

    CSIR Research Space (South Africa)

    Green, Cheri A

    2012-10-01

    Full Text Available - Providing government services in an spatially equitable manner: Perspectives for Fire Station location CSIR: Built Environment October 2012 Analyse Existing Service Accessibility and Availability Explore & adjust facility locations & sizes... and distribution ? Facility operational thresholds- max & min size Basic approach and principles of facility location planning: WHO gets WHAT, WHERE and HOW MUCH ? Accessibility analysis models the access of residents to facilities - assuming people will go...

  18. Optimal Facility Location Tool for Logistics Battle Command (LBC)

    Science.gov (United States)

    2015-08-01

    possible A/SPODs. 71 A-82 Appendix B. VBA Code The following screen shots of the VBA code are provided to document the code used to run the model ...research is to develop a model that optimizes the selection of Air and Sea Ports of Debarkation and intermediate logistical distribution centers while...conduct transportation in a theater of operations. The model developed by AFIT uses a network approach to solve a multi-objective model . The model was

  19. Availability Estimation for Facilities in Extreme Geographical Locations

    Science.gov (United States)

    Fischer, Gerd M.; Omotoso, Oluseun; Chen, Guangming; Evans, John W.

    2012-01-01

    A value added analysis for the Reliability. Availability and Maintainability of McMurdo Ground Station was developed, which will be a useful tool for system managers in sparing, maintenance planning and determining vital performance metrics needed for readiness assessment of the upgrades to the McMurdo System. Output of this study can also be used as inputs and recommendations for the application of Reliability Centered Maintenance (RCM) for the system. ReliaSoft's BlockSim. a commercial Reliability Analysis software package, has been used to model the availability of the system upgrade to the National Aeronautics and Space Administration (NASA) Near Earth Network (NEN) Ground Station at McMurdo Station in the Antarctica. The logistics challenges due to the closure of access to McMurdo Station during the Antarctic winter was modeled using a weighted composite of four Weibull distributions. one of the possible choices for statistical distributions throughout the software program and usually used to account for failure rates of components supplied by different manufacturers. The inaccessibility of the antenna site on a hill outside McMurdo Station throughout one year due to severe weather was modeled with a Weibull distribution for the repair crew availability. The Weibull distribution is based on an analysis of the available weather data for the antenna site for 2007 in combination with the rules for travel restrictions due to severe weather imposed by the administrating agency, the National Science Foundation (NSF). The simulations resulted in an upper bound for the system availability and allowed for identification of components that would improve availability based on a higher on-site spare count than initially planned.

  20. Law Enforcement Locations

    Data.gov (United States)

    Kansas Data Access and Support Center — Law Enforcement Locations in Kansas Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law enforcement agencies "are...