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Sample records for eyespot focus determination

  1. Focusing on butterfly eyespot focus: uncoupling of white spots from eyespot bodies in nymphalid butterflies.

    Science.gov (United States)

    Iwata, Masaki; Otaki, Joji M

    2016-01-01

    Developmental studies on butterfly wing color patterns often focus on eyespots. A typical eyespot (such as that of Bicyclus anynana) has a few concentric rings of dark and light colors and a white spot (called a focus) at the center. The prospective eyespot center during the early pupal stage is known to act as an organizing center. It has often been assumed, according to gradient models for positional information, that a white spot in adult wings corresponds to an organizing center and that the size of the white spot indicates how active that organizing center was. However, there is no supporting evidence for these assumptions. To evaluate the feasibility of these assumptions in nymphalid butterflies, we studied the unique color patterns of Calisto tasajera (Nymphalidae, Satyrinae), which have not been analyzed before in the literature. In the anterior forewing, one white spot was located at the center of an eyespot, but another white spot associated with either no or only a small eyespot was present in the adjacent compartment. The anterior hindwing contained two adjacent white spots not associated with eyespots, one of which showed a sparse pattern. The posterior hindwing contained two adjacent pear-shaped eyespots, and the white spots were located at the proximal side or even outside the eyespot bodies. The successive white spots within a single compartment along the midline in the posterior hindwing showed a possible trajectory of a positional determination process for the white spots. Several cases of focus-less eyespots in other nymphalid butterflies were also presented. These results argue for the uncoupling of white spots from eyespot bodies, suggesting that an eyespot organizing center does not necessarily differentiate into a white spot and that a prospective white spot does not necessarily signify organizing activity for an eyespot. Incorporation of these results in future models for butterfly wing color pattern formation is encouraged.

  2. Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns.

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    Zhang, Linlin; Reed, Robert D

    2016-06-15

    Butterfly eyespot colour patterns are a key example of how a novel trait can appear in association with the co-option of developmental patterning genes. Little is known, however, about how, or even whether, co-opted genes function in eyespot development. Here we use CRISPR/Cas9 genome editing to determine the roles of two co-opted transcription factors that are expressed during early eyespot determination. We found that deletions in a single gene, spalt, are sufficient to reduce or completely delete eyespot colour patterns, thus demonstrating a positive regulatory role for this gene in eyespot determination. Conversely, and contrary to previous predictions, deletions in Distal-less (Dll) result in an increase in the size and number of eyespots, illustrating a repressive role for this gene in eyespot development. Altogether our results show that the presence, absence and shape of butterfly eyespots can be controlled by the activity of two co-opted transcription factors.

  3. A Model for Selection of Eyespots on Butterfly Wings.

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    Toshio Sekimura

    Full Text Available The development of eyespots on the wing surface of butterflies of the family Nympalidae is one of the most studied examples of biological pattern formation.However, little is known about the mechanism that determines the number and precise locations of eyespots on the wing. Eyespots develop around signaling centers, called foci, that are located equidistant from wing veins along the midline of a wing cell (an area bounded by veins. A fundamental question that remains unsolved is, why a certain wing cell develops an eyespot, while other wing cells do not.We illustrate that the key to understanding focus point selection may be in the venation system of the wing disc. Our main hypothesis is that changes in morphogen concentration along the proximal boundary veins of wing cells govern focus point selection. Based on previous studies, we focus on a spatially two-dimensional reaction-diffusion system model posed in the interior of each wing cell that describes the formation of focus points. Using finite element based numerical simulations, we demonstrate that variation in the proximal boundary condition is sufficient to robustly select whether an eyespot focus point forms in otherwise identical wing cells. We also illustrate that this behavior is robust to small perturbations in the parameters and geometry and moderate levels of noise. Hence, we suggest that an anterior-posterior pattern of morphogen concentration along the proximal vein may be the main determinant of the distribution of focus points on the wing surface. In order to complete our model, we propose a two stage reaction-diffusion system model, in which an one-dimensional surface reaction-diffusion system, posed on the proximal vein, generates the morphogen concentrations that act as non-homogeneous Dirichlet (i.e., fixed boundary conditions for the two-dimensional reaction-diffusion model posed in the wing cells. The two-stage model appears capable of generating focus point distributions

  4. Origin, development, and evolution of butterfly eyespots.

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    Monteiro, Antónia

    2015-01-07

    This article reviews the latest developments in our understanding of the origin, development, and evolution of nymphalid butterfly eyespots. Recent contributions to this field include insights into the evolutionary and developmental origin of eyespots and their ancestral deployment on the wing, the evolution of eyespot number and eyespot sexual dimorphism, and the identification of genes affecting eyespot development and black pigmentation. I also compare features of old and more recently proposed models of eyespot development and propose a schematic for the genetic regulatory architecture of eyespots. Using this schematic I propose two hypotheses for why we observe limits to morphological diversity across these serially homologous traits.

  5. Eyespot evolution: phylogenetic insights from Junonia and related butterfly genera (Nymphalidae: Junoniini).

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    Kodandaramaiah, Ullasa

    2009-01-01

    Butterfly eyespots have been the focus of a number of developmental and evolutionary studies. However, a phylogenetic component has rarely been explicitly incorporated in these studies. In this study, I utilize a phylogeny to trace the evolution of eyespot number and position on the wing in a group of nymphalid butterflies, the subtribe Junoniini. These butterflies have two kinds of eyespot arrangements which I refer to as Serial and Individual. In the Serial arrangement, eyespots are placed in a series on compartments 1-6 (counting from the anterior wing margin). In the Individual arrangement, eyespots are isolated on specific compartments, ranging from 1 to 4 in number. This can be divided into four subtypes based on the number and positions of eyespots. I map the evolution of these five arrangements over a phylogeny of Junoniini reconstructed with ca. 3000 base pairs of sequence data from three genes. The results show that almost all arrangements have evolved at least twice, with multiple shifts between them by addition and deletion of eyespots. I propose a model involving genetic or developmental coupling between eyespots in specific compartments to explain these shifts. I discuss their evolution in light of existing knowledge about their development. I also discuss potential explanations for functional significance of the eyespot patterns found in the group. Differential selection for and against eyespots, both at different times over the phylogeny and in different regions, have driven the evolution of eyespot arrangements. The study throws open many questions about the adaptive significance of eyespots and the developmental underpinnings of the various arrangements.

  6. Prediction of eyespot infection risks

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    M. Váòová

    2012-12-01

    Full Text Available The objective of the study was to design a prediction model for eyespot (Tapesia yallundae infection based on climatic factors (temperature, precipitation, air humidity. Data from experiment years 1994-2002 were used to study correlations between the eyespot infection index and individual weather characteristics. The model of prediction was constructed using multiple regression when a separate parameter is assigned to each factor, i.e. the frequency of days with optimum temperatures, humidity, and precipitation. The correlation between relative air humidity and precipitation and the infection index is significant.

  7. Attack risk for butterflies changes with eyespot number and size

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    Ho, Sebastian; Schachat, Sandra R.; Piel, William H.; Monteiro, Antónia

    2016-01-01

    Butterfly eyespots are known to function in predator deflection and predator intimidation, but it is still unclear what factors cause eyespots to serve one function over the other. Both functions have been demonstrated in different species that varied in eyespot size, eyespot number and wing size, leaving the contribution of each of these factors to butterfly survival unclear. Here, we study how each of these factors contributes to eyespot function by using paper butterfly models, where each factor is varied in turn, and exposing these models to predation in the field. We find that the presence of multiple, small eyespots results in high predation, whereas single large eyespots (larger than 6 mm in diameter) results in low predation. These data indicate that single large eyespots intimidate predators, whereas multiple small eyespots produce a conspicuous, but non-intimidating signal to predators. We propose that eyespots may gain an intimidation function by increasing in size. Our measurements of eyespot size in 255 nymphalid butterfly species show that large eyespots are relatively rare and occur predominantly on ventral wing surfaces. By mapping eyespot size on the phylogeny of the family Nymphalidae, we show that these large eyespots, with a potential intimidation function, are dispersed throughout multiple nymphalid lineages, indicating that phylogeny is not a strong predictor of eyespot size. PMID:26909190

  8. Attack risk for butterflies changes with eyespot number and size.

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    Ho, Sebastian; Schachat, Sandra R; Piel, William H; Monteiro, Antónia

    2016-01-01

    Butterfly eyespots are known to function in predator deflection and predator intimidation, but it is still unclear what factors cause eyespots to serve one function over the other. Both functions have been demonstrated in different species that varied in eyespot size, eyespot number and wing size, leaving the contribution of each of these factors to butterfly survival unclear. Here, we study how each of these factors contributes to eyespot function by using paper butterfly models, where each factor is varied in turn, and exposing these models to predation in the field. We find that the presence of multiple, small eyespots results in high predation, whereas single large eyespots (larger than 6 mm in diameter) results in low predation. These data indicate that single large eyespots intimidate predators, whereas multiple small eyespots produce a conspicuous, but non-intimidating signal to predators. We propose that eyespots may gain an intimidation function by increasing in size. Our measurements of eyespot size in 255 nymphalid butterfly species show that large eyespots are relatively rare and occur predominantly on ventral wing surfaces. By mapping eyespot size on the phylogeny of the family Nymphalidae, we show that these large eyespots, with a potential intimidation function, are dispersed throughout multiple nymphalid lineages, indicating that phylogeny is not a strong predictor of eyespot size.

  9. Alternative models for the evolution of eyespots and of serial homology on lepidopteran wings.

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    Monteiro, Antónia

    2008-04-01

    Serial homology is widespread in organismal design, but the origin and individuation of these repeated structures appears to differ with the different types of serial homologues, and remains an intriguing and exciting topic of research. Here I focus on the evolution of the serially repeated eyespots that decorate the margin of the wings of nymphalid butterflies. In this system, unresolved questions relate to the evolutionary steps that lead to the appearance of these serial homologues and how their separate identities evolved. I present and discuss two alternative hypotheses. The first proposes that eyespots first appeared as a row of undifferentiated repeated modules, one per wing compartment, that later become individuated. This individuation allowed eyespots to appear and disappear from specific wing compartments and also allowed eyespots to acquire different morphologies. The second hypothesis proposes that eyespots first appeared as individuated single units, or groups of units, that over evolutionary time were co-opted into new compartments on the wing. I discuss the merits of each of these alternate hypotheses by finding analogies to other systems and propose research avenues for addressing these issues in the future.

  10. A Survey of Eyespot Sexual Dimorphism across Nymphalid Butterflies

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    Tokita, Christopher K.; Oliver, Jeffrey C.; Monteiro, Antónia

    2013-01-01

    Differences between sexes of the same species are widespread and are variable in nature. While it is often assumed that males are more ornamented than females, in the nymphalid butterfly genus Bicyclus, females have, on average, more eyespot wing color patterns than males. Here we extend these studies by surveying eyespot pattern sexual dimorphism across the Nymphalidae family of butterflies. Eyespot presence or absence was scored from a total of 38 wing compartments for two males and two females of each of 450 nymphalid species belonging to 399 different genera. Differences in eyespot number between sexes of each species were tallied for each wing surface (e.g., dorsal and ventral) of forewings and hindwings. In roughly 44% of the species with eyespots, females had more eyespots than males, in 34%, males had more eyespots than females, and, in the remaining 22% of the species, there was monomorphism in eyespot number. Dorsal and forewing surfaces were less patterned, but proportionally more dimorphic, than ventral and hindwing surfaces, respectively. In addition, wing compartments that frequently displayed eyespots were among the least sexually dimorphic. This survey suggests that dimorphism arises predominantly in “hidden” or “private” surfaces of a butterfly's wing, as previously demonstrated for the genus Bicyclus. PMID:24381783

  11. Physiological Perturbation Reveals Modularity of Eyespot Development in the Painted Lady Butterfly, Vanessa cardui.

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    Connahs, Heidi; Rhen, Turk; Simmons, Rebecca B

    2016-01-01

    Butterfly eyespots are complex morphological traits that can vary in size, shape and color composition even on the same wing surface. Homology among eyespots suggests they share a common developmental basis and function as an integrated unit in response to selection. Despite strong evidence of genetic integration, eyespots can also exhibit modularity or plasticity, indicating an underlying flexibility in pattern development. The extent to which particular eyespots or eyespot color elements exhibit modularity or integration is poorly understood, particularly following exposure to novel conditions. We used perturbation experiments to explore phenotypic correlations among different eyespots and their color elements on the ventral hindwing of V. cardui. Specifically, we identified which eyespots and eyespot features are most sensitive to perturbation by heat shock and injection of heparin-a cold shock mimic. For both treatments, the two central eyespots (3 + 4) were most affected by the experimental perturbations, whereas the outer eyespot border was more resistant to modification than the interior color elements. Overall, the individual color elements displayed a similar response to heat shock across all eyespots, but varied in their response to each other. Graphical modeling also revealed that although eyespots differ morphologically, regulation of eyespot size and colored elements appear to be largely integrated across the wing. Patterns of integration, however, were disrupted following heat shock, revealing that the strength of integration varies across the wing and is strongest between the two central eyespots. These findings support previous observations that document coupling between eyespots 3 + 4 in other nymphalid butterflies.

  12. Colour pattern homology and evolution in Vanessa butterflies (Nymphalidae: Nymphalini): eyespot characters.

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    Abbasi, R; Marcus, J M

    2015-11-01

    Ocelli are serially repeated colour patterns on the wings of many butterflies. Eyespots are elaborate ocelli that function in predator avoidance and deterrence as well as in mate choice. A phylogenetic approach was used to study ocelli and eyespot evolution in Vanessa butterflies, a genus exhibiting diverse phenotypes among these serial homologs. Forty-four morphological characters based on eyespot number, arrangement, shape and the number of elements in each eyespot were defined and scored. Ocelli from eight wing cells on the dorsal and ventral surfaces of the forewing and hindwing were evaluated. The evolution of these characters was traced over a phylogeny of Vanessa based on 7750 DNA base pairs from 10 genes. Our reconstruction predicts that the ancestral Vanessa had 5 serially arranged ocelli on all four wing surfaces. The ancestral state on the dorsal forewing and ventral hindwing was ocelli arranged in two heterogeneous groups. On the dorsal hindwing, the ancestral state was either homogenous or ocelli arranged in two heterogeneous groups. On the ventral forewing, we determined that the ancestral state was organized into three heterogeneous groups. In Vanessa, almost all ocelli are individuated and capable of independent evolution relative to other colour patterns except for the ocelli in cells -1 and 0 on the dorsal and ventral forewings, which appear to be constrained to evolve in parallel. The genus Vanessa is a good model system for the study of serial homology and the interaction of selective forces with developmental architecture to produce diversity in butterfly colour patterns. © 2015 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2015 European Society For Evolutionary Biology.

  13. A single origin for nymphalid butterfly eyespots followed by widespread loss of associated gene expression.

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    Jeffrey C Oliver

    Full Text Available Understanding how novel complex traits originate involves investigating the time of origin of the trait, as well as the origin of its underlying gene regulatory network in a broad comparative phylogenetic framework. The eyespot of nymphalid butterflies has served as an example of a novel complex trait, as multiple genes are expressed during eyespot development. Yet the origins of eyespots remain unknown. Using a dataset of more than 400 images of butterflies with a known phylogeny and gene expression data for five eyespot-associated genes from over twenty species, we tested origin hypotheses for both eyespots and eyespot-associated genes. We show that eyespots evolved once within the family Nymphalidae, approximately 90 million years ago, concurrent with expression of at least three genes associated with early eyespot development. We also show multiple losses of expression of most genes from this early three-gene cluster, without corresponding losses of eyespots. We propose that complex traits, such as eyespots, may have originated via co-option of a large pre-existing complex gene regulatory network that was subsequently streamlined of genes not required to fulfill its novel developmental function.

  14. Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution.

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    Keys, D N; Lewis, D L; Selegue, J E; Pearson, B J; Goodrich, L V; Johnson, R L; Gates, J; Scott, M P; Carroll, S B

    1999-01-22

    The origin of new morphological characters is a long-standing problem in evolutionary biology. Novelties arise through changes in development, but the nature of these changes is largely unknown. In butterflies, eyespots have evolved as new pattern elements that develop from special organizers called foci. Formation of these foci is associated with novel expression patterns of the Hedgehog signaling protein, its receptor Patched, the transcription factor Cubitus interruptus, and the engrailed target gene that break the conserved compartmental restrictions on this regulatory circuit in insect wings. Redeployment of preexisting regulatory circuits may be a general mechanism underlying the evolution of novelties.

  15. Butterfly Eyespots: Their Potential Influence on Aesthetic Preferences and Conservation Attitudes.

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    Zoi Manesi

    Full Text Available Research has shown that the mere presence of stimuli that resemble eyes is sufficient to attract attention, elicit aesthetic responses, and can even enhance prosocial behavior. However, it is less clear whether eye-like stimuli could also be used as a tool for nature conservation. Several animal species, including butterflies, develop eye-like markings that are known as eyespots. In the present research, we explored whether the mere display of eyespots on butterfly wings can enhance: (a liking for a butterfly species, and (b attitudes and behaviors towards conservation of a butterfly species. Four online experimental studies, involving 613 participants, demonstrated that eyespots significantly increased liking for a butterfly species. Furthermore, eyespots significantly increased positive attitudes towards conservation of a butterfly species (Studies 1, 2 and 4, whereas liking mediated the eyespot effect on conservation attitudes (Study 2. However, we also found some mixed evidence for an association between eyespots and actual conservation behavior (Studies 3 and 4. Overall, these findings suggest that eyespots may increase liking for an animal and sensitize humans to conservation. We discuss possible implications for biodiversity conservation and future research directions.

  16. Butterfly Eyespots: Their Potential Influence on Aesthetic Preferences and Conservation Attitudes.

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    Manesi, Zoi; Van Lange, Paul A M; Pollet, Thomas V

    2015-01-01

    Research has shown that the mere presence of stimuli that resemble eyes is sufficient to attract attention, elicit aesthetic responses, and can even enhance prosocial behavior. However, it is less clear whether eye-like stimuli could also be used as a tool for nature conservation. Several animal species, including butterflies, develop eye-like markings that are known as eyespots. In the present research, we explored whether the mere display of eyespots on butterfly wings can enhance: (a) liking for a butterfly species, and (b) attitudes and behaviors towards conservation of a butterfly species. Four online experimental studies, involving 613 participants, demonstrated that eyespots significantly increased liking for a butterfly species. Furthermore, eyespots significantly increased positive attitudes towards conservation of a butterfly species (Studies 1, 2 and 4), whereas liking mediated the eyespot effect on conservation attitudes (Study 2). However, we also found some mixed evidence for an association between eyespots and actual conservation behavior (Studies 3 and 4). Overall, these findings suggest that eyespots may increase liking for an animal and sensitize humans to conservation. We discuss possible implications for biodiversity conservation and future research directions.

  17. Evidence for the Deflective Function of Eyespots in Wild Junonia evarete Cramer (Lepidoptera, Nymphalidae).

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    Pinheiro, C E G; Antezana, M A; Machado, L P

    2014-02-01

    Junonia evarete Cramer is a fast-flying butterfly that perches on the ground with wings opened exhibiting four eyespots close to wing borders. These eyespots presumably function either to intimidate predators, like insectivorous birds, or to deflect bird attacks to less vital parts of the body. We assessed the form, frequency, and location of beak marks on the wings of wild butterflies in central Brazil during two not consecutive years. We found that almost 50% of males and 80% of females bore signals of predator attacks (wing tears), most of them consisting of partially or totally V-shaped forms apparently produced by birds. Males were significantly less attacked and showed a lower proportion of attacks on eyespots than females, suggesting they are better to escape bird attacks. In contrast, females were heavily attacked on eyespots. Eyespot tears in females were higher (and significant different) than expected by chance, indicating that birds do attempt to reach the eyespots when striking on these butterflies. Other comparisons involving the proportion of tears directed or not directed to eyespots in males and females are presented and discussed.

  18. The feeding habits of the eyespot skate Atlantoraja cyclophora (Elasmobranchii: Rajiformes in southeastern Brazil

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    Alessandra da Fonseca Viana

    2014-04-01

    Full Text Available The stomach contents of the eyespot skate, Atlantoraja cyclophora (Regan, 1903, were examined with the goal to provide information about the diet of the species. Samples were collected off the southern coast of Rio de Janeiro, Brazil, near Ilha Grande, between January 2006 and August 2007, at a depth of about 60 m. The diet was analyzed by sex, maturity stages and quarterly to verify differences in the importance of food items. The latter were analyzed by: frequency of occurrence, percentage of weight and in the Alimentary Index. The trophic niche width was determined to assess the degree of specialization in the diet. Additionally, the degree of dietary overlap between males and females; juveniles and adults and periods of the year were defined. A total of 59 individuals of A. cyclophora were captured. Females and adults were more abundant. The quarters with the highest concentrations of individuals were in the summer of the Southern Hemisphere: Jan-Feb-Mar 06 and Jan-Feb-Mar 07. Prey items were classed into five main groups: Crustacea, Teleosts, Elasmobranchs, Polychaeta, and Nematoda. The most important groups in the diet of the eyespot skate were Crustacea and Teleosts. The crab Achelous spinicarpus (Stimpson, 1871 was the most important item. The value of the niche width was small, indicating that a few food items are important. The comparison of the diet between males and females and juveniles and adults indicates a significant overlap between the sexes and stages of maturity; and according to quarters, the importance of prey groups differed (crustaceans were more important in the quarters of the summer and teleost in Jul-Aug-Sep and Oct-Nov-Dec 06, indicating seasonal differences in diet composition. Three groups with similar diets were formed in the cluster analysis: (Jan-Feb-Mar 06 and 07; (Apr-May-Jun 06 and Jul-Aug-Sep 07; (Jul-Aug-Sep 06 and Oct-Nov-Dec 06.

  19. The function of animal 'eyespots':Conspicuousness but not eye mimicry is key

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    Martin STEVENS; Abi CANTOR; Julia GRAHAM; Isabel S. WINNEY

    2009-01-01

    Many animals are marked with conspicuous circular features often called ' eyespots', which intimidate predators, preventing or halting an attack. It has long been assumed that eyespots work by mimicking the eyes of larger animals, but recent experiments have indicated that conspicuousness and contrast is important in eyespot function, and not eye mimicry. We undertake two further experiments to distinguish between the conspicuousness and mimicry hypotheses, by using artificial prey presented to wild avian predators in the field. In experiment 1, we test if eyespot effectiveness depends on the marking shape (bar or circle) and arrangement (eye-like and non-eye-like positions). We find no difference between shapes or arrangement; all spots were equally effective in scaring birds. In experiment 2, we test if the often yellow and black colors of eyespots mimic the eyes of birds of prey. We find no effect of shape, and no advantage to yellow and black spots over non-eye-like but equally conspicuous colors. The consistent finding is that eyespot function lies in being a conspicuous signal to predators, and not necessarily due to eye mimicry [Current Zoology 55 (5): 319-326, 2009].

  20. Marginal eyespots on butterfly wings deflect bird attacks under low light intensities with UV wavelengths.

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    Martin Olofsson

    Full Text Available BACKGROUND: Predators preferentially attack vital body parts to avoid prey escape. Consequently, prey adaptations that make predators attack less crucial body parts are expected to evolve. Marginal eyespots on butterfly wings have long been thought to have this deflective, but hitherto undemonstrated function. METHODOLOGY/PRINCIPAL FINDINGS: Here we report that a butterfly, Lopinga achine, with broad-spectrum reflective white scales in its marginal eyespot pupils deceives a generalist avian predator, the blue tit, to attack the marginal eyespots, but only under particular conditions-in our experiments, low light intensities with a prominent UV component. Under high light intensity conditions with a similar UV component, and at low light intensities without UV, blue tits directed attacks towards the butterfly head. CONCLUSIONS/SIGNIFICANCE: In nature, birds typically forage intensively at early dawn, when the light environment shifts to shorter wavelengths, and the contrast between the eyespot pupils and the background increases. Among butterflies, deflecting attacks is likely to be particularly important at dawn when low ambient temperatures make escape by flight impossible, and when insectivorous birds typically initiate another day's search for food. Our finding that the deflective function of eyespots is highly dependent on the ambient light environment helps explain why previous attempts have provided little support for the deflective role of marginal eyespots, and we hypothesize that the mechanism that we have discovered in our experiments in a laboratory setting may function also in nature when birds forage on resting butterflies under low light intensities.

  1. Automatic section thickness determination using an absolute gradient focus function.

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    Elozory, D T; Kramer, K A; Chaudhuri, B; Bonam, O P; Goldgof, D B; Hall, L O; Mouton, P R

    2012-12-01

    Quantitative analysis of microstructures using computerized stereology systems is an essential tool in many disciplines of bioscience research. Section thickness determination in current nonautomated approaches requires manual location of upper and lower surfaces of tissue sections. In contrast to conventional autofocus functions that locate the optimally focused optical plane using the global maximum on a focus curve, this study identified by two sharp 'knees' on the focus curve as the transition from unfocused to focused optical planes. Analysis of 14 grey-scale focus functions showed, the thresholded absolute gradient function, was best for finding detectable bends that closely correspond to the bounding optical planes at the upper and lower tissue surfaces. Modifications to this function generated four novel functions that outperformed the original. The 'modified absolute gradient count' function outperformed all others with an average error of 0.56 μm on a test set of images similar to the training set; and, an average error of 0.39 μm on a test set comprised of images captured from a different case, that is, different staining methods on a different brain region from a different subject rat. We describe a novel algorithm that allows for automatic section thickness determination based on just out-of-focus planes, a prerequisite for fully automatic computerized stereology.

  2. Fungicide resistance status in French populations of the wheat eyespot fungi Oculimacula acuformis and Oculimacula yallundae.

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    Leroux, Pierre; Gredt, Michel; Remuson, Florent; Micoud, Annie; Walker, Anne-Sophie

    2013-01-01

    Eyespot, caused by Oculimacula acuformis and Oculimacula yallundae, is the major foot disease of winter wheat in several European countries, including France. It can be controlled by chemical treatment between tillering and the second node stage. The fungicides used include antimicrotubule toxicants (benzimidazoles), inhibitors of sterol 14α-demethylation (DMIs) or of succinate dehydrogenase (SDHIs), the anilinopyrimidines cyprodinil and the benzophenone metrafenone. Since the early 1980s, a long-term survey has been set up in France to monitor changes in the sensitivity of eyespot populations to fungicides. Resistance to benzimidazoles has become generalised since the early 1990s, in spite of the withdrawal of this class of fungicides. In the DMI group, resistance to triazoles is generalised, whereas no resistance to the triazolinethione prothioconazole has yet developed. Resistance to the imidazole prochloraz evolved successively in O. acuformis and O. yallundae and is now well established. Specific resistance to cyprodinil has also been detected, but its frequency has generally remained low. Finally, since the early 2000s, a few strains of O. yallundae displaying multidrug resistance (MDR) have been detected. These strains display low levels of resistance to prothioconazole and SDHIs, such as boscalid. Knowledge of the spatiotemporal distribution in France of O. acuformis and O. yallundae field strains resistant to fungicides allows resistance management strategies for eyespot fungi in winter wheat to be proposed.

  3. Self-assembled film thickness determination by focused ion beam

    Energy Technology Data Exchange (ETDEWEB)

    Dejeu, J. [Institut UTINAM, UMR 6213 CNRS-UFC - equipe Materiaux et Surfaces Structures, Universite de Franche-Comte, UFR Sciences et Techniques, 16 route de Gray - 25030 Besancon Cedex (France)], E-mail: jerome.dejeu@univ-fcomte.fr; Salut, R. [Institut FEMTO-ST, UMR 6174 CNRS-UFC-UTBM-ENSMM, Centrale MIMENTO, Universite de Franche-Comte, 32 avenue de l' Observatoire - 25044 Besancon Cedex (France); Spajer, M. [Institut FEMTO-ST, UMR 6174 CNRS-UFC-UTBM-ENSMM, Centrale MIMENTO, Universite de Franche-Comte, 32 avenue de l' Observatoire - 25044 Besancon Cedex (France); Institut FEMTO-ST, UMR 6174 CNRS-UFC-UTBM-ENSMM, Departement d' Optique, Universite de Franche-Comte, UFR Sciences et Techniques, 16 route de Gray - 25030 Besancon Cedex (France); Membrey, F.; Foissy, A. [Institut UTINAM, UMR 6213 CNRS-UFC - equipe Materiaux et Surfaces Structures, Universite de Franche-Comte, UFR Sciences et Techniques, 16 route de Gray - 25030 Besancon Cedex (France); Charraut, D. [Institut FEMTO-ST, UMR 6174 CNRS-UFC-UTBM-ENSMM, Departement d' Optique, Universite de Franche-Comte, UFR Sciences et Techniques, 16 route de Gray - 25030 Besancon Cedex (France)

    2008-06-30

    The thickness evolution of multilayer film is investigated by focused ion beam (FIB) in the domain of polymer multilayers. This method, currently used in the modification and the characterization of integrated circuits, proves it is possible to determine the polymer film thickness. Sample cutting and its observation of the cross-section are performed in the FIB without leaving the vacuum chamber. Two main conclusions can be drawn: (1) the roughness of the film increases with the number of layer deposit, (2) the film growth changes from nonlinear (called exponential) to linear beyond 300 nm (70 layers)

  4. METHOD FOR DETERMINATION OF FOCAL PLANE LOCATION OF FOCUSING COMPONENTS

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    A. I. Ivashko

    2017-01-01

    Full Text Available Mass-production of different laser systems often requires utilization of the focal spot size method for determination of output laser beam spatial characteristics. The main challenge of this method is high accuracy maintenance of a CCD camera beam profiler in the collecting lens focal plane. The aim of our work is development of new method for placing of photodetector array in the collecting lens focal plane with high accuracy.Proposed technique is based on focusing of several parallel laser beams. Determination of the focal plane position requires only longitudinal translation of the CCD-camera to find a point of laser beams intersection. Continuous-wave (CW diode-pumped laser emitting in the spectral region near 1μm was created to satisfy the requirements of the developed technique. Designed microchip laser generates two stigmatic Gaussian beams with automatically parallel beam axes due to independent pumping of different areas of the one microchip crystal having the same cavity mirrors.It was theoretically demonstrated that developed method provides possibility of the lenses focal plane determination with 1 % accuracy. The microchip laser generates two parallel Gaussian beams with divergence of about 10 mrad. Laser output power can be varied in the range of 0.1–1.5 W by changing the pumping laser diode electrical current. The distance between two beam axes can be changed in the range of 0.5–5.0 mm.We have proposed method for determination of positive lens focal plane location by using of CCDcamera and two laser beams with parallel axes without utilization of additional optical devices. We have developed CW longitudinally diode pumped microchip laser emitting in the 1-μm spectral region that can be used in the measuring instrument that doesn’t require precision mechanical components for determination of focal plane location with 1 % accuracy. The overall dimensions of laser head was 70 × 40 × 40 mm3 and maximum power consumption was

  5. Do uric acid deposits in zooxanthellae function as eye-spots?

    Directory of Open Access Journals (Sweden)

    Hiroshi Yamashita

    Full Text Available The symbiosis between zooxanthellae (dinoflagellate genus Symbiodinium and corals is a fundamental basis of tropical marine ecosystems. However the physiological interactions of the hosts and symbionts are poorly understood. Recently, intracellular crystalline deposits in Symbiodinium were revealed to be uric acid functioning for nutrient storage. This is the first exploration of these enigmatic crystalline materials that had previously been misidentified as oxalic acid, providing new insights into the nutritional strategies of Symbiodinium in oligotrophic tropical waters. However, we believe these deposits also function as eye-spots on the basis of light and electron microscopic observations of motile cells of cultured Symbiodinium. The cells possessed crystalline deposit clusters in rows with each row 100-150 nm thick corresponding to 1/4 the wavelength of light and making them suitable for maximum wave interference and reflection of light. Crystalline clusters in cells observed with a light microscope strongly refracted and polarized light, and reflected or absorbed short wavelength light. The facts that purines, including uric acid, have been identified as the main constituents of light reflectors in many organisms, and that the photoreceptor protein, opsin, was detected in our Symbiodinium strain, support the idea that uric acid deposits in Symbiodinium motile cells may function as a component of an eye-spot.

  6. A wheat cinnamyl alcohol dehydrogenase TaCAD12 contributes to host resistance to the sharp eyespot disease

    Directory of Open Access Journals (Sweden)

    Wei Rong

    2016-11-01

    Full Text Available Sharp eyespot, caused mainly by the necrotrophic fungus Rhizoctonia cerealis, is a destructive disease in hexaploid wheat (Triticum aestivum L.. In Arabidopsis, certain cinnamyl alcohol dehydrogenases (CADs have been implicated in monolignol biosynthesis and in defense response to bacterial pathogen infection. However, little is known about CADs in wheat defense responses to necrotrophic or soil-borne pathogens. In this study, we isolate a wheat CAD gene TaCAD12 in response to R. cerealis infection through microarray-based comparative transcriptomics, and study the enzyme activity and defense role of TaCAD12 in wheat. The transcriptional levels of TaCAD12 in sharp eyespot-resistant wheat lines were significantly higher compared with those in susceptible wheat lines. The sequence and phylogenetic analyses revealed that TaCAD12 belongs to IV group in CAD family. The biochemical assay proved that TaCAD12 protein is an authentic CAD enzyme and possesses catalytic efficiencies towards both coniferyl aldehyde and sinapyl aldehyde. Knock-down of TaCAD12 transcript significantly repressed resistance of the gene-silenced wheat plants to sharp eyespot caused by R. cerealis, whereas TaCAD12 overexpression markedly enhanced resistance of the transgenic wheat lines to sharp eyespot. Furthermore, certain defense genes (Defensin, PR10, PR17c, and Chitinase1 and monolignol biosynthesis-related genes (TaCAD1, TaCCR, and TaCOMT1 were up-regulated in the TaCAD12-overexpressing wheat plants but down-regulated in TaCAD12-silencing plants. These results suggest that TaCAD12 positively contributes to resistance against sharp eyespot through regulation of the expression of certain defense genes and monolignol biosynthesis-related genes in wheat.

  7. How do eyespot resistance genes transferred into winter wheat breeding lines affect their yield?

    Directory of Open Access Journals (Sweden)

    Kwiatek Michał

    2016-12-01

    Full Text Available Eyespot can reduce yields, even up to 50%. There are four genetically characterized resistances in wheat varieties, controlled by: (1 the Pch1 gene, transferred from Aegilops ventricosa; (2 the Pch2 gene, originating from wheat variety Capelle Desprez; (3 the Pch3 gene, originating from Dasypyrum villosum; and (4 the Q.Pch.jic-5A gene, a quantitative trait locus (QTL located on chromosome 5A of Capelle Desprez. However, those loci have drawbacks, such as linkage of Pch1 with deleterious traits and limited effectiveness of Pch2 against the disease. Here we present an initial study which aims to characterize wheat pre-registration breeding lines carrying 12 eyespot resistance genes, consider their resistance expression in inoculation tests and the influence of resistance genotypes on the yield. We selected four groups of breeding lines, carrying: (1 the Pch1 gene alone: one line; (2 the Pch2 gene alone: four lines; (3 the Q.Pch.jic-5A gene alone: one line; and (4 Pch1 + Q.Pch.jic-5A: three lines. For the first time, the effect of the combination of Pch1 and Q.Pch.jic-5A genes was compared with resistance conferred by Pch1 or Q.Pch.jic-5A alone. We found significant differences between infection scores evaluated in resistant lines carrying Pch1 and Q.Pch.jic-5A alone, while no differences in terms of the level of resistance expression were detected between Pch1 alone and Pch1 + Q.Pch.jic-5A, and between wheat lines carrying Pch1 and Pch2 alone. Moreover, we demonstrated that the Pch1 gene, together with an Ae. ventricosa segment, caused statistically significant yield losses, both as a single eyespot resistance source or in a combination with Q.Pch.jic-5A. Yield scores showed that wheat lines with Q.Pch.jic-5A had the highest yields, similar to the yielding potential of Pch2-bearing lines and control varieties.

  8. Color pattern evolution in Vanessa butterflies (Nymphalidae: Nymphalini): non-eyespot characters.

    Science.gov (United States)

    Abbasi, Roohollah; Marcus, Jeffrey M

    2015-01-01

    A phylogenetic approach was used to study color pattern evolution in Vanessa butterflies. Twenty-four color pattern elements from the Nymphalid ground plan were identified on the dorsal and ventral surfaces of the fore- and hind wings. Eyespot characters were excluded and will be examined elsewhere. The evolution of each character was traced over a Bayesian phylogeny of Vanessa reconstructed from 7750 DNA base pairs from 10 genes. Generally, the correspondence between character states on the same surface of the two wings is stronger on the ventral side compared to the dorsal side. The evolution of character states on both sides of a wing correspond with each other in most extant species, but the correspondence between dorsal and ventral character states is much stronger in the forewing than in the hindwing. The dorsal hindwing of many species of Vanessa is covered with an extended Basal Symmetry System and the Discalis I pattern element is highly variable between species, making this wing surface dissimilar to the other wing surfaces. The Basal Symmetry System and Discalis I may contribute to behavioral thermoregulation in Vanessa. Overall, interspecific directional character state evolution of non-eyespot color patterns is relatively rare in Vanessa, with a majority of color pattern elements showing non-variable, non-directional, or ambiguous character state evolution. The ease with which the development of color patterns can be modified, including character state reversals, has likely made important contributions to the production of color pattern diversity in Vanessa and other butterfly groups. © 2014 Wiley Periodicals, Inc.

  9. Rapid determination of enantiomeric excess: a focus on optical approaches.

    Science.gov (United States)

    Leung, Diana; Kang, Sung Ok; Anslyn, Eric V

    2012-01-07

    High-throughput screening (HTS) methods are becoming increasingly essential in discovering chiral catalysts or auxiliaries for asymmetric transformations due to the advent of parallel synthesis and combinatorial chemistry. Both parallel synthesis and combinatorial chemistry can lead to the exploration of a range of structural candidates and reaction conditions as a means to obtain the highest enantiomeric excess (ee) of a desired transformation. One current bottleneck in these approaches to asymmetric reactions is the determination of ee, which has led researchers to explore a wide range of HTS techniques. To be truly high-throughput, it has been proposed that a technique that can analyse a thousand or more samples per day is needed. Many of the current approaches to this goal are based on optical methods because they allow for a rapid determination of ee due to quick data collection and their parallel analysis capabilities. In this critical review these techniques are reviewed with a discussion of their respective advantages and drawbacks, and with a contrast to chromatographic methods (180 references).

  10. A motivational determinant of facial emotion recognition: regulatory focus affects recognition of emotions in faces.

    Science.gov (United States)

    Sassenrath, Claudia; Sassenberg, Kai; Ray, Devin G; Scheiter, Katharina; Jarodzka, Halszka

    2014-01-01

    Two studies examined an unexplored motivational determinant of facial emotion recognition: observer regulatory focus. It was predicted that a promotion focus would enhance facial emotion recognition relative to a prevention focus because the attentional strategies associated with promotion focus enhance performance on well-learned or innate tasks - such as facial emotion recognition. In Study 1, a promotion or a prevention focus was experimentally induced and better facial emotion recognition was observed in a promotion focus compared to a prevention focus. In Study 2, individual differences in chronic regulatory focus were assessed and attention allocation was measured using eye tracking during the facial emotion recognition task. Results indicated that the positive relation between a promotion focus and facial emotion recognition is mediated by shorter fixation duration on the face which reflects a pattern of attention allocation matched to the eager strategy in a promotion focus (i.e., striving to make hits). A prevention focus did not have an impact neither on perceptual processing nor on facial emotion recognition. Taken together, these findings demonstrate important mechanisms and consequences of observer motivational orientation for facial emotion recognition.

  11. In-situ and non-destructive focus determination device for high-precision laser applications

    Science.gov (United States)

    Armbruster, Oskar; Naghilou, Aida; Pöhl, Hannes; Kautek, Wolfgang

    2016-09-01

    A non-destructive, in-line, and low-cost focusing device based on an image sensor has been developed and demonstrated. It allows an in situ focus determination for a broad variety of laser types (e.g. cw and pulsed lasers). It provides stringent focusing conditions with high numerical apertures. This approach does not require sub-picosecond and/or auxiliary lasers, or high fluences above damage thresholds. Applications of this system include, but are not limited to the laser-illumination of micro-electrodes, pump-probe microscopy on thin films, and laser ablation of small samples without sufficient surface area for focus determination by ablation. An uncertainty of the focus position by an order of magnitude less than the respective Rayleigh length could be demonstrated.

  12. Motivation and career-development training programs: Use of regulatory focus to determine program effectiveness

    OpenAIRE

    Anthony, Peter John; Weide, Jeffrey

    2015-01-01

    Higgins (2005) developed a motivational theory that distinguishes between two foci: preventative and promotion. Individuals with a preventative focus are motivated to complete activities due to a necessity or expectation. However, those with a promotion focus find motivation from advancement, self-improvement, or social impact. Writers typically use Higgins’ theory on workplace teams and psychology, yet the theory has usefulness for determining training program effectiveness (Carter, 2011; Fr...

  13. Status quo and future research challenges on organic food quality determination with focus on laboratory methods

    NARCIS (Netherlands)

    Kahl, J.; Bodroza-Solarov, M.; Busscher, N.; Hajslova, J.; Kneifel, W.; Kokornaczyk, M.O.; Ruth, van S.M.; Schulzova, V.; Stolz, P.

    2014-01-01

    Organic food quality determination needs multi-dimensional evaluation tools. The main focus is on the authentication as an analytical verification of the certification process. New fingerprinting approaches such as ultra-performance liquid chromatography–mass spectrometry, gas chromatography–mass

  14. Endocrine determinants of haemostasis and thrombosis risk: Focus on thyroid hormone

    NARCIS (Netherlands)

    Elbers, L.P.B.

    2016-01-01

    This thesis explores endocrine determinants of the haemostatic system and thrombosis risk with main focus on thyroid hormone. It describes, in three parts, the effects of thyroid hormone on the haemostatic system, the effects of thyroid hormone (mimetics) on lipids and the effects of other hormones

  15. Status quo and future research challenges on organic food quality determination with focus on laboratory methods

    NARCIS (Netherlands)

    Kahl, J.; Bodroza-Solarov, M.; Busscher, N.; Hajslova, J.; Kneifel, W.; Kokornaczyk, M.O.; Ruth, van S.M.; Schulzova, V.; Stolz, P.

    2014-01-01

    Organic food quality determination needs multi-dimensional evaluation tools. The main focus is on the authentication as an analytical verification of the certification process. New fingerprinting approaches such as ultra-performance liquid chromatography–mass spectrometry, gas chromatography–mass sp

  16. Determination of near-surface material properties by line-focus acoustic microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Achenbach, J.D.; Li, W. [Northwestern Univ., Evanston, IL (United States)

    1996-12-31

    A line-focus acoustic microscope is used in conjunction with a multiple wave-mode method to determine elastic constants from a single V(z) measurement. V(z) curves which include contributions from different wave modes, measured using the line-focus acoustic microscope at 225 MHz, have been compared with theoretical results predicted by a V(z) measurement model. The determination of elastic constants has been achieved numerically by seeking a set of elastic constants that leads to the best fit, in the least square sense, of the theoretical results to the experimental ones. The method has been applied to isotropic materials in bulk, and plate and thin-film configurations. Elastic constants for each of these cases have been determined. The consistency, convergence, sensitivity and accuracy of the procedure have been investigated.

  17. On the accuracy potential of focused plenoptic camera range determination in long distance operation

    Science.gov (United States)

    Sardemann, Hannes; Maas, Hans-Gerd

    2016-04-01

    Plenoptic cameras have found increasing interest in optical 3D measurement techniques in recent years. While their basic principle is 100 years old, the development in digital photography, micro-lens fabrication technology and computer hardware has boosted the development and lead to several commercially available ready-to-use cameras. Beyond their popular option of a posteriori image focusing or total focus image generation, their basic ability of generating 3D information from single camera imagery depicts a very beneficial option for certain applications. The paper will first present some fundamentals on the design and history of plenoptic cameras and will describe depth determination from plenoptic camera image data. It will then present an analysis of the depth determination accuracy potential of plenoptic cameras. While most research on plenoptic camera accuracy so far has focused on close range applications, we will focus on mid and long ranges of up to 100 m. This range is especially relevant, if plenoptic cameras are discussed as potential mono-sensorial range imaging devices in (semi-)autonomous cars or in mobile robotics. The results show the expected deterioration of depth measurement accuracy with depth. At depths of 30-100 m, which may be considered typical in autonomous driving, depth errors in the order of 3% (with peaks up to 10-13 m) were obtained from processing small point clusters on an imaged target. Outliers much higher than these values were observed in single point analysis, stressing the necessity of spatial or spatio-temporal filtering of the plenoptic camera depth measurements. Despite these obviously large errors, a plenoptic camera may nevertheless be considered a valid option for the application fields of real-time robotics like autonomous driving or unmanned aerial and underwater vehicles, where the accuracy requirements decrease with distance.

  18. Genome-wide association mapping of resistance to eyespot disease (Pseudocercosporella herpotrichoides) in European winter wheat (Triticum aestivum L.) and fine-mapping of Pch1.

    Science.gov (United States)

    Zanke, Christine D; Rodemann, Bernd; Ling, Jie; Muqaddasi, Quddoos H; Plieske, Jörg; Polley, Andreas; Kollers, Sonja; Ebmeyer, Erhard; Korzun, Viktor; Argillier, Odile; Stiewe, Gunther; Zschäckel, Thomas; Ganal, Martin W; Röder, Marion S

    2017-03-01

    Genotypes with recombination events in the Triticum ventricosum introgression on chromosome 7D allowed to fine-map resistance gene Pch1, the main source of eyespot resistance in European winter wheat cultivars. Eyespot (also called Strawbreaker) is a common and serious fungal disease of winter wheat caused by the necrotrophic fungi Oculimacula yallundae and Oculimacula acuformis (former name Pseudocercosporella herpotrichoides). A genome-wide association study (GWAS) for eyespot was performed with 732 microsatellite markers (SSR) and 7761 mapped SNP markers derived from the 90 K iSELECT wheat array using a panel of 168 European winter wheat varieties as well as three spring wheat varieties and phenotypic evaluation of eyespot in field tests in three environments. Best linear unbiased estimations (BLUEs) were calculated across all trials and ranged from 1.20 (most resistant) to 5.73 (most susceptible) with an average value of 4.24 and a heritability of H (2) = 0.91. A total of 108 SSR and 235 SNP marker-trait associations (MTAs) were identified by considering associations with a -log10 (P value) ≥3.0. Significant MTAs for eyespot-score BLUEs were found on chromosomes 1D, 2A, 2D, 3D, 5A, 5D, 6A, 7A and 7D for the SSR markers and chromosomes 1B, 2A, 2B, 2D, 3B and 7D for the SNP markers. For 18 varieties (10.5%), a highly resistant phenotype was detected that was linked to the presence of the resistance gene Pch1 on chromosome 7D. The identification of genotypes with recombination events in the introgressed genomic segment from Triticum ventricosum harboring the Pch1 resistance gene on chromosome 7DL allowed the fine-mapping of this gene using additional SNP markers and a potential candidate gene Traes_7DL_973A33763 coding for a CC-NBS-LRR class protein was identified.

  19. Reaction of corn genotypes to eyespot caused by Kabatiella zeaeReação de genótipos de milho à mancha ocular causada por Kabatiella zeae

    Directory of Open Access Journals (Sweden)

    Sérgio Miguel Mazaro

    2012-08-01

    Full Text Available The objective of this study was to evaluate the reaction of corn genotypes to eyespot caused by Kabatiella zeae under natural field conditions. The assay was carried out during the 2006/2007 growing season, in Pato Branco-Paraná State, consisting of 33 hybrids and two sowing seasons, on 10/13 and 12/27/2006, respectively; and in the 2007/2008 growing season, in the same place, with 10 hybrids and two sowing seasons, on 10/20 and 11/12/2007, respectively, and in Palma Sola-Santa Catarina State, with 8 hybrids and one sowing season, on 09/30/2007. Disease intensity was determined by means of severity evaluations. The observed corn plant reactions allowed genotypes with different levels of eyespot resistance to be discriminated. Hybrids AG 9020 and SPRINT were the most susceptible to the disease, while AS 1565 and DKB 234 were the most resistant; this behavior was repeated in both years and growing seasons. It was concluded that the variation in susceptibility to eyespot among the hybrids tested, may have been influenced by ambient conditions.O objetivo deste trabalho foi avaliar a reação de genótipos de milho quanto à mancha ocular causada por Kabatiella zeae sob condições naturais de infecção. Os ensaios foram instalados na safra 2006/2007, no município de Pato Branco, PR, com 33 híbridos e com duas épocas de semeadura, dia 13/10 e 27/12/2006, respectivamente; e na safra 2007/2008, no mesmo município, com 10 híbridos e com duas épocas de semeadura, dia 20/10 e 12/11/2007, respectivamente e no município de Palma Sola, SC, com oito híbridos e com uma época de semeadura, dia 30/09/2007. A intensidade da doença foi determinada pela avaliação de severidade em todos os híbridos de milho, em diferentes estádios de desenvolvimento. As reações de milho observadas permitem separar estatisticamente genótipos com diferentes níveis de resistência à mancha ocular. Os híbridos AG 9020 e SPRINT apresentaram maior suscetibilidade

  20. Focused ultrasound solid-liquid extraction for the determination of organic biomarkers in beachrocks.

    Science.gov (United States)

    Blanco-Zubiaguirre, L; Arrieta, N; Iturregui, A; Martinez-Arkarazo, I; Olivares, M; Castro, K; Olazabal, M A; Madariaga, J M

    2015-11-01

    Beachrocks are consolidated coastal sedimentary formations resulting mainly from the relative rapid cementation of beach sediments by different calcium carbonate polymorphs. Although previous works have already studied the elemental composition and the mineral phases composing these cements, few of them have focused their attention on the organic matter present therein. This work describes an extraction methodology based on focused ultrasound solid-liquid extraction (FUSLE), followed by analysis using large volume injection (LVI) in a programmable temperature vaporizer (PTV) combined with gas chromatography-mass spectrometry (GC-MS) in order to determine organics such as polycyclic aromatic hydrocarbons (PAHs) and biomarkers (hopanes), which can increase and confirm the information obtained so far. This goal has been achieved after the optimization of the main parameters affecting the extraction procedure, such as, extraction solvent, FUSLE variables (amplitude, extraction time and pulse time) and also variables affecting the LVI-PTV (vent time, injection speed and cryo-focusing temperature). The developed method rendered results comparable to traditional extraction methods in terms of accuracy (77-109%) and repeatability (RSD<23%). Finally, the analyses performed over real beachrock samples from the Bay of Biscay (Northern Spain) revealed the presence of the 16 EPA priority PAHs, as well as some organic biomarkers which could increase the knowledge about such beachrock formation.

  1. Diet composition and feeding habits of the eyespot skate, Atlantoraja cyclophora (Elasmobranchii: Arhynchobatidae, off Uruguay and northern Argentina

    Directory of Open Access Journals (Sweden)

    Santiago A. Barbini

    Full Text Available ABSTRACT The eyespot skate, Atlantoraja cyclophora, is an endemic species from the southwestern Atlantic, occurring from Rio de Janeiro, Brazil, to northern Patagonia, Argentina. The feeding habits of this species, from off Uruguay and north Argentina, were evaluated using a multiple hypothesis modelling approach. In general, the diet was composed mainly of decapod crustaceans, followed by teleost fishes. Molluscs, mysidaceans, amphipods, isopods, lancelets and elasmobranchs were consumed in lower proportion. The consumption of shrimps drecreased with increasing body size of A. cyclophora. On the other hand, the consumption of teleosts increased with body size. Mature individuals preyed more heavily on crabs than immature individuals. Teleosts were consumed more in the south region (34º - 38ºS and crabs in the north region (38º - 41ºS. Shrimps were eaten more in the warm season than in the cold season. Prey size increased with increasing body size of A. cyclophora , but large individuals also consumed small teleosts and crabs. Atlantoraja cyclophora has demersal-benthic feeding habits, shifts its diet with increasing body size and in response to seasonal and regional changes in prey availability and distribution.

  2. An algorithm for determining use of trauma-focused cognitive-behavioral therapy.

    Science.gov (United States)

    Lang, Jason M; Ford, Julian D; Fitzgerald, Monica M

    2010-12-01

    The shift toward dissemination of evidence-based practices has led to many questions about who is appropriate for a particular treatment model, particularly with complex clients, in diverse community settings, and when multiple evidence-based models have overlapping target populations. Few research-based tools exist to facilitate these clinical decisions. The research on trauma-focused cognitive-behavioral therapy (TF-CBT), an evidence-based treatment for children suffering from posttraumatic stress reactions, is reviewed to inform development of an algorithm to assist clinicians in determining whether a particular client is appropriate for TF-CBT. Recommendations are made for future research that will facilitate matching TF-CBT and other evidence-based practices to particular child clients.

  3. Status quo and future research challenges on organic food quality determination with focus on laboratory methods.

    Science.gov (United States)

    Kahl, Johannes; Bodroza-Solarov, Marija; Busscher, Nicolaas; Hajslova, Jana; Kneifel, Wolfgang; Kokornaczyk, Maria Olga; van Ruth, Saskia; Schulzova, Vera; Stolz, Peter

    2014-10-01

    Organic food quality determination needs multi-dimensional evaluation tools. The main focus is on the authentication as an analytical verification of the certification process. New fingerprinting approaches such as ultra-performance liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry, direct analysis in real time-high-resolution mass spectrometry as well as crystallization with and without the presence of additives seem to be promising methods in terms of time of analysis and detecting organic system-related parameters. For further methodological development, a system approach is recommended, which also takes into account food structure aspects. Furthermore, the authentication of processed organic samples needs more consciousness, hence most of organic food is complex and processed. © 2013 Society of Chemical Industry.

  4. In situ determination of the static inductance and resistance of a plasma focus capacitor bank.

    Science.gov (United States)

    Saw, S H; Lee, S; Roy, F; Chong, P L; Vengadeswaran, V; Sidik, A S M; Leong, Y W; Singh, A

    2010-05-01

    The static (unloaded) electrical parameters of a capacitor bank are of utmost importance for the purpose of modeling the system as a whole when the capacitor bank is discharged into its dynamic electromagnetic load. Using a physical short circuit across the electromagnetic load is usually technically difficult and is unnecessary. The discharge can be operated at the highest pressure permissible in order to minimize current sheet motion, thus simulating zero dynamic load, to enable bank parameters, static inductance L(0), and resistance r(0) to be obtained using lightly damped sinusoid equations given the bank capacitance C(0). However, for a plasma focus, even at the highest permissible pressure it is found that there is significant residual motion, so that the assumption of a zero dynamic load introduces unacceptable errors into the determination of the circuit parameters. To overcome this problem, the Lee model code is used to fit the computed current trace to the measured current waveform. Hence the dynamics is incorporated into the solution and the capacitor bank parameters are computed using the Lee model code, and more accurate static bank parameters are obtained.

  5. Determinants of eating behaviour in university students: a qualitative study using focus group discussions.

    Science.gov (United States)

    Deliens, Tom; Clarys, Peter; De Bourdeaudhuij, Ilse; Deforche, Benedicte

    2014-01-18

    College or university is a critical period regarding unhealthy changes in eating behaviours in students. Therefore, the purpose of this study was to explore which factors influence Belgian (European) university students' eating behaviour, using a qualitative research design. Furthermore, we aimed to collect ideas and recommendations in order to facilitate the development of effective and tailored intervention programs aiming to improve healthy eating behaviours in university students. Using a semi-structured question guide, five focus group discussions have been conducted consisting of 14 male and 21 female university students from a variety of study disciplines, with a mean age of 20.6 ± 1.7 yrs. Using Nvivo9, an inductive thematic approach was used for data analysis. After the transition from secondary school to university, when independency increases, students are continuously challenged to make healthful food choices. Students reported to be influenced by individual factors (e.g. taste preferences, self-discipline, time and convenience), their social networks (e.g. (lack of) parental control, friends and peers), physical environment (e.g. availability and accessibility, appeal and prices of food products), and macro environment (e.g. media and advertising). Furthermore, the relationships between determinants and university students' eating behaviour seemed to be moderated by university characteristics, such as residency, student societies, university lifestyle and exams. Recommendations for university administrators and researchers include providing information and advice to enhance healthy food choices and preparation (e.g. via social media), enhancing self-discipline and self-control, developing time management skills, enhancing social support, and modifying the subjective as well as the objective campus food environment by e.g. making healthy foods price-beneficial and by providing vending machines with more healthy products. This is the first European

  6. The phosphotransferase system gene ptsI in the endophytic bacterium Bacillus cereus is required for biofilm formation, colonization, and biocontrol against wheat sharp eyespot.

    Science.gov (United States)

    Xu, Yu-Bin; Chen, Mai; Zhang, Ying; Wang, Miao; Wang, Ying; Huang, Qiu-bin; Wang, Xue; Wang, Gang

    2014-05-01

    Natural resistance of wheat plants to wheat sharp eyespot is inadequate, and new strategies for controlling the disease are required. Biological control is an alternative and attractive way of reducing the use of chemicals in agriculture. In this study, we investigated the biocontrol properties of endophytic bacterium Bacillus cereus strain 0-9, which was isolated from the root systems of healthy wheat varieties. The phosphotransferase system is a major regulator of carbohydrate metabolism in bacteria. Enzyme I is one of the protein components of this system. Specific disruption and complementation of the enzyme I-coding gene ptsI from B. cereus was achieved through homologous recombination. Disruption of ptsI in B. cereus caused a 70% reduction in biofilm formation, a 30.4% decrease in biocontrol efficacy, and a 1000-fold reduction in colonization. The growth of ΔptsI mutant strain on G-tris synthetic medium containing glucose as the exclusive carbon source was also reduced. Wild-type properties could be restored to the ΔptsI mutant strain by ptsI complementation. These results suggested that ptsI may be one of the key genes involved in biofilm formation, colonization, and biocontrol of B. cereus and that B. cereus wild-type strain 0-9 may be an ideal biocontrol agent for controlling wheat sharp eyespot.

  7. The Role of Regulatory Focus in Determining Career-Development Training Program Effectiveness

    Science.gov (United States)

    Weide, Jeffrey Lee

    2014-01-01

    American organizations spend over $135 billion annually on training with an unknown return on investment. When budgets decline, leaders typically reduce training, despite the known influence of such training on employee motivation. To explore the perceptions of government-focused project managers regarding the effect of a lack of standardized…

  8. Future time perspective and promotion focus as determinants of intraindividual change in work motivation.

    Science.gov (United States)

    Kooij, Dorien T A M; Bal, P Matthijs; Kanfer, Ruth

    2014-06-01

    In the near future, workforces will increasingly consist of older workers. At the same time, research has demonstrated that work-related growth motives decrease with age. Although this finding is consistent with life span theories, such as the selection optimization and compensation (SOC) model, we know relatively little about the process variables that bring about this change in work motivation. Therefore, we use a 4-wave study design to examine the mediating role of future time perspective and promotion focus in the negative association between age and work-related growth motives. Consistent with the SOC model, we found that future time perspective was negatively associated with age, which, in turn, was associated with lower promotion focus, lower work-related growth motive strength, and lower motivation to continue working. These findings have important theoretical implications for the literature on aging and work motivation, and practical implications for how to motivate older workers. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  9. Psychological determinants of financial buffer saving : The influence of financial risk tolerance and regulatory focus

    NARCIS (Netherlands)

    Magendans, J.; Gutteling, Jan M.; Zebel, Sven

    With governments redistributing more responsibilities unto citizens, individuals have an increasing need for financial resources acting as a buffer against life’s setbacks and unexpected expenditures. The purpose of this study was to examine psychological determinants of saving for a financial

  10. Psychological determinants of financial buffer saving: The influence of financial risk tolerance and regulatory focus

    NARCIS (Netherlands)

    Magendans, J.; Gutteling, J.M.; Zebel, S.

    2016-01-01

    With governments redistributing more responsibilities unto citizens, individuals have an increasing need for financial resources acting as a buffer against life’s setbacks and unexpected expenditures. The purpose of this study was to examine psychological determinants of saving for a financial buffe

  11. Isoelectric points of proteins, determined by isoelectric focusing in the presence of urea and ethanol

    NARCIS (Netherlands)

    Gelsema, W.J.; Ligny, C.L. de; Veen, N.G. van der

    1979-01-01

    Isoelectric points, pIapp, in sucrose-urea-water and glycerol-ethanol-water mixtures and isoelectric points, pI, in water have been determined at 25° for some carrier ampholytes. The differences, pIapp---pI, are shown to account for the primary medium effect and the pH measuring cell effect on the

  12. Isoelectric points of proteins, determined by isoelectric focusing in the presence of urea and ethanol

    NARCIS (Netherlands)

    Gelsema, W.J.; Ligny, C.L. de; Veen, N.G. van der

    1979-01-01

    Isoelectric points, pIapp, in sucrose-urea-water and glycerol-ethanol-water mixtures and isoelectric points, pI, in water have been determined at 25° for some carrier ampholytes. The differences, pIapp---pI, are shown to account for the primary medium effect and the pH measuring cell effect on the i

  13. Prenatal determinants of optic nerve hypoplasia: Review of suggested correlates and future focus

    OpenAIRE

    Garcia-Filion, Pamela; Borchert, Mark

    2013-01-01

    Optic nerve hypoplasia (ONH), a congenital malformation characterized by an underdeveloped optic nerve, is a seemingly epidemic cause of childhood blindness and visual impairment with associated lifelong morbidity. While the prenatal determinants of ONH are unknown, early case reports have led to a longstanding speculation that risky health behaviors (e.g. recreational drugs, alcohol) are a likely culprit. There has yet to be a systematic review of the epidemiology of ONH to assess the common...

  14. Continuation of Mass determinations through a Double Focusing Mass Spectrometer on Line with ISOLDE

    CERN Multimedia

    2002-01-01

    In a previous experiment (1976-77) we have demonstrated the interest and feasibility of atomic mass determinations from the direct measurements of mass ratios on Rb, Cs and Fr isotopes. Masses of long series of isotopes on both side of stability were determined with an accuracy of a few tens to 300 keV (for th exotic). Interesting nuclear structure features could be observed as for example the indication for an onset of deformation, at N~=~60 for Z~=~37, which stimulated further experiments and theoretical calculations. The many mass values, until then unknown, we obtained in our experiments, gave in addition the possibility to make detailed tests of the nuclear mass predictions. Due to improvements on our mass spectrometer (better transmission and higher resolving power) and increased ISOLDE production yields, some new and valuable measurements can be performed. We plan: \\item a) to continue the measurements towards even heavier isotopes and explore the deformation regions which start at |9|7Rb and |1|4|6Cs;...

  15. Using focus groups to investigate service quality determinants for customer satisfaction in selected university libraries in Sri Lanka

    Directory of Open Access Journals (Sweden)

    Chaminda Jayasundara

    2010-01-01

    Full Text Available This study aimed at establishing service quality determinants which may affect customer satisfaction in university libraries in Sri Lanka. Using the literature, 113 service quality determinants were identified. These were then reviewed by eight focus groups in four different universities. Forty of the determinants were perceived to be applicable to their context. The participants also added 14 quality requirements which they thought were not provided for in the list. Finally, the content and face validity of the 54 determinants were evaluated by a panel of experts who ultimately reduced them to 50. This study recommends the use of the identified quality determinants by library administrators and policymakers in the higher education sector in Sri Lanka to gauge the levels of customer satisfaction and assure quality of service.

  16. Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology

    Directory of Open Access Journals (Sweden)

    Zhaohui Ni

    2017-02-01

    Full Text Available As one of the most influential and troublesome human pathogens, Acinetobacter baumannii (A. baumannii has emerged with many multidrug-resistant strains. After collecting 33 complete A. baumannii genomes and 84 representative antibiotic resistance determinants, we used the Vaxign reverse vaccinology approach to predict classical type vaccine candidates against A. baumannii infections and new type vaccine candidates against antibiotic resistance. Our genome analysis identified 35 outer membrane or extracellular adhesins that are conserved among all 33 genomes, have no human protein homology, and have less than 2 transmembrane helices. These 35 antigens include 11 TonB dependent receptors, 8 porins, 7 efflux pump proteins, and 2 fimbrial proteins (FilF and CAM87009.1. CAM86003.1 was predicted to be an adhesin outer membrane protein absent from 3 antibiotic-sensitive strains and conserved in 21 antibiotic-resistant strains. Feasible anti-resistance vaccine candidates also include one extracellular protein (QnrA, 3 RND type outer membrane efflux pump proteins, and 3 CTX-M type β-lactamases. Among 39 β-lactamases, A. baumannii CTX-M-2, -5, and -43 enzymes are predicted as adhesins and better vaccine candidates than other β-lactamases to induce preventive immunity and enhance antibiotic treatments. This report represents the first reverse vaccinology study to systematically predict vaccine antigen candidates against antibiotic resistance for a microbial pathogen.

  17. Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology

    Science.gov (United States)

    Ni, Zhaohui; Chen, Yan; Ong, Edison; He, Yongqun

    2017-01-01

    As one of the most influential and troublesome human pathogens, Acinetobacter baumannii (A. baumannii) has emerged with many multidrug-resistant strains. After collecting 33 complete A. baumannii genomes and 84 representative antibiotic resistance determinants, we used the Vaxign reverse vaccinology approach to predict classical type vaccine candidates against A. baumannii infections and new type vaccine candidates against antibiotic resistance. Our genome analysis identified 35 outer membrane or extracellular adhesins that are conserved among all 33 genomes, have no human protein homology, and have less than 2 transmembrane helices. These 35 antigens include 11 TonB dependent receptors, 8 porins, 7 efflux pump proteins, and 2 fimbrial proteins (FilF and CAM87009.1). CAM86003.1 was predicted to be an adhesin outer membrane protein absent from 3 antibiotic-sensitive strains and conserved in 21 antibiotic-resistant strains. Feasible anti-resistance vaccine candidates also include one extracellular protein (QnrA), 3 RND type outer membrane efflux pump proteins, and 3 CTX-M type β-lactamases. Among 39 β-lactamases, A. baumannii CTX-M-2, -5, and -43 enzymes are predicted as adhesins and better vaccine candidates than other β-lactamases to induce preventive immunity and enhance antibiotic treatments. This report represents the first reverse vaccinology study to systematically predict vaccine antigen candidates against antibiotic resistance for a microbial pathogen. PMID:28230771

  18. Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology.

    Science.gov (United States)

    Ni, Zhaohui; Chen, Yan; Ong, Edison; He, Yongqun

    2017-02-21

    As one of the most influential and troublesome human pathogens, Acinetobacter baumannii (A. baumannii) has emerged with many multidrug-resistant strains. After collecting 33 complete A. baumannii genomes and 84 representative antibiotic resistance determinants, we used the Vaxign reverse vaccinology approach to predict classical type vaccine candidates against A. baumannii infections and new type vaccine candidates against antibiotic resistance. Our genome analysis identified 35 outer membrane or extracellular adhesins that are conserved among all 33 genomes, have no human protein homology, and have less than 2 transmembrane helices. These 35 antigens include 11 TonB dependent receptors, 8 porins, 7 efflux pump proteins, and 2 fimbrial proteins (FilF and CAM87009.1). CAM86003.1 was predicted to be an adhesin outer membrane protein absent from 3 antibiotic-sensitive strains and conserved in 21 antibiotic-resistant strains. Feasible anti-resistance vaccine candidates also include one extracellular protein (QnrA), 3 RND type outer membrane efflux pump proteins, and 3 CTX-M type β-lactamases. Among 39 β-lactamases, A. baumannii CTX-M-2, -5, and -43 enzymes are predicted as adhesins and better vaccine candidates than other β-lactamases to induce preventive immunity and enhance antibiotic treatments. This report represents the first reverse vaccinology study to systematically predict vaccine antigen candidates against antibiotic resistance for a microbial pathogen.

  19. Inclusion of the equity focus and social determinants of health in health care education programmes in Colombia: a qualitative approach.

    Science.gov (United States)

    Hernández-Rincón, Erwin H; Pimentel-González, Juan P; Orozco-Beltrán, Domingo; Carratalá-Munuera, Concepción

    2016-06-01

    The Pan American Health Organization (PAHO) and the Colombian Ministry of Health and Social Protection have determined a need for an approach to include Equity Focus (EF) and Social Determinants of Health (SDH) in health training programmes in Colombia. We studied the incorporation of EF and SDH in the curricula of several universities in Colombia to identify opportunities to strengthen their inclusion. Qualitative methodology was performed in two stages: (i) initial exploration (self-administered questionnaires and review of curricula) and (ii) validation of the information (semi-structured interviews). The inclusion of the EF and SDH in university curricula is regarded as an opportunity to address social problems. This approach addresses a broad cross-section of the curriculum, especially in the subjects of public health and Primary Health Care (PHC), where community outreach generates greater internalization by students. The dominance of the biomedical model of study plans and practice scenarios focusing on disease and little emphasis on community outreach are factors that limit the inclusion of the approach. The inclusion of EF and SDH in university curricula in Colombia has primarily focused on increasing the knowledge of various subjects oriented towards understanding the social dynamics or comprehensiveness of health and disease and, in some programmes, through practical courses in community health and PHC. Increased integration of EF and SDH in subjects or modules with clinical orientation is recommended. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  20. Determination of tissue thermal conductivity by measuring and modeling temperature rise induced in tissue by pulsed focused ultrasound.

    Directory of Open Access Journals (Sweden)

    Tamara Kujawska

    Full Text Available A tissue thermal conductivity (Ks is an important parameter which knowledge is essential whenever thermal fields induced in selected organs are predicted. The main objective of this study was to develop an alternative ultrasonic method for determining Ks of tissues in vitro suitable for living tissues. First, the method involves measuring of temperature-time T(t rises induced in a tested tissue sample by a pulsed focused ultrasound with measured acoustic properties using thermocouples located on the acoustic beam axis. Measurements were performed for 20-cycle tone bursts with a 2 MHz frequency, 0.2 duty-cycle and 3 different initial pressures corresponding to average acoustic powers equal to 0.7 W, 1.4 W and 2.1 W generated from a circular focused transducer with a diameter of 15 mm and f-number of 1.7 in a two-layer system of media: water/beef liver. Measurement results allowed to determine position of maximum heating located inside the beef liver. It was found that this position is at the same axial distance from the source as the maximum peak-peak pressure calculated for each nonlinear beam produced in the two-layer system of media. Then, the method involves modeling of T(t at the point of maximum heating and fitting it to the experimental data by adjusting Ks. The averaged value of Ks determined by the proposed method was found to be 0.5±0.02 W/(m·°C being in good agreement with values determined by other methods. The proposed method is suitable for determining Ks of some animal tissues in vivo (for example a rat liver.

  1. Psychosocial determinants of fruit and vegetable consumption among students in a New Zealand university. Results of focus group interviews.

    Science.gov (United States)

    Hartman, Hilde; Wadsworth, Daniel P; Penny, Suzi; van Assema, Patricia; Page, Rachel

    2013-06-01

    The '5+ a day' fruit and vegetable servings recommendation was introduced in New Zealand in 1994, but consumption has remained low in young adults ever since. This study aimed to identify psychosocial determinants of fruit and vegetable consumption among New Zealand university students approximately a decade after the guidelines' introduction. Twenty-nine students, aged 18-24 years, took part in focus group interviews. Important determinants included taste and health awareness/knowledge. Flatmates and partners had the greatest social influence. Cost and availability were major barriers to consumption. To improve consumption participants suggested: cooking sessions providing quick/easy recipes; more-varied nutritional information; 'made-to-measure' interventions; increasing awareness of cheap sources of fruit/vegetables; and increasing campus availability of fruit. Determinants including a negative attitude, a lack of self-efficacy and an unawareness of dietary guidelines/health consequences should be considered when developing interventions for this group, whilst a variety of different delivery channels should be used. Participants in the study were not representative of all university students, who generally have a different lifestyle to other young adults and specific determinants for fruit/vegetable consumption. Consequently, additional research is required among other young adults and university students with lower fruit and vegetable intake, so that promotional strategies can be specifically targeted.

  2. Determination of electric field at and near the focus of a cylindrical lens for applications in fluorescence microscopy

    Directory of Open Access Journals (Sweden)

    Subhajit B. Purnapatra

    2013-05-01

    Full Text Available We present an explicit computable integral solution of the electric field generated at the focal region of a cylindrical lens. This representation is based on vectorial diffraction theory and further enables the computation of the system point spread function of a cylindrical lens. It is assumed that there is no back-scattering and the contribution from the evanescent field is negligible. Stationary phase approximation along with the Fresnel transmission coefficients are employed for evaluating the polarization dependent electric field components. Studies were carried out to determine the polarization effects and to calculate the system resolution. The effect of s −, p − and randomly polarized light is studied on the fixed sample (electric dipole is fixed in space. Proposed approach allows better understanding of electric field effects at the focus of a cylindrical aplanatic system. This opens up future developments in the field of fluorescence microscopy and optical imaging.

  3. Determination of plutonium concentrations and isotope ratios in environmental samples with a double-focusing sector field ICP-MS

    Energy Technology Data Exchange (ETDEWEB)

    Rodushkin, I. [Svensk Grundaemnesanalys AB, Luleaa University of Technology, S-971 87 Luleaa (Sweden); Lindahl, P. [Department of Radiation Physics, Lund University, S-221 85 Lund (Sweden); Holm, E. [Department of Radiation Physics, Lund University, S-221 85 Lund (Sweden); Roos, P. [Department of Radiation Physics, Lund University, S-221 85 Lund (Sweden)

    1999-03-01

    An analytical method for the ultratrace and isotopic analysis of plutonium in sediment samples using a double focusing sector field ICP mass spectrometer (ICP-SMS) is described. A detection limit for plutonium in the sub-fg ml{sup -1} range was achieved. The ICP-SMS results were in acceptable agreement with alpha spectrometry. At the low fg ml{sup -1} level a precision in isotope ratio measurements of 2-10% RSD was achieved. Accuracy of the results was assessed by {sup 238}U/{sup 235}U and {sup 205}Tl/{sup 203}Tl isotope ratio determinations using isotopic standards and a natural Tl standard solution, respectively. It was shown that correction for {sup 238}UH{sup +} and {sup 238}UH{sup +}{sub 2} is necessary for both plutonium concentration and isotopic composition determinations. From a practical standpoint, the use of ICP-SMS for plutonium measurements is an attractive alternative to techniques such as alpha spectrometry and thermal ionization mass spectrometry (TIMS) due to its higher throughput and ability to measure both concentration and isotopic ratio on the same sample.

  4. 防治小麦纹枯病有益内生细菌的筛选%Selection of Beneficial Endophytic Bacteria for Biological Control of Wheat Sharp Eyespot

    Institute of Scientific and Technical Information of China (English)

    张海燕; 张颖; 王磊; 刘凤英; 王刚

    2011-01-01

    A total of 296 endophytic bacterium strains were isolated from 38 samples of healthy wheat roots collected from western area of Henan province. In vivo tests were used to acquire efficient biocon-trol strains against wheat sharp eyespot and the results showed that 13 strains could reduce significantly the incidence and severity of wheat sharp eyespot. Among endophytic bacteria isolates, strain Z8 - 15 had the best biocontrol efficacy against wheat sharp eyespot, reaching 81. 82%. Antagonistic activities against Rhizoctonia cereali and Gaeumannomyces graminis var. Tritici, and abilities to produce fungi cell wall degradation enzymes such as glucanase, chitinase, proteinase, etc, of 13 endophytic bacteria were tested on plate. The results of obvious difference between strains indicated that different biocontrol mechanisms existed among different endophytic bacteria.%从采自河南西部地区的38份健康小麦根系内分离到小麦内生细菌296株.通过活体植株筛选,从中获得的13株细菌,可显著降低小麦纹枯病的发病率和严重度,其中菌株Z8-15的生防效果最好,防效达到81.82%.在平板上测定了13个菌株对小麦纹枯病菌和小麦全蚀病菌的拮抗能力以及产生葡聚糖酶、几丁质酶和蛋白酶等真菌细胞壁降解酶的能力,发现不同菌株间差别明显,暗示不同内生生防菌株对小麦纹枯病可能具有不同的生防机制.

  5. Determinants of physical activity and sedentary behaviour in university students: a qualitative study using focus group discussions.

    Science.gov (United States)

    Deliens, Tom; Deforche, Benedicte; De Bourdeaudhuij, Ilse; Clarys, Peter

    2015-02-28

    College or university is a critical period regarding unhealthy changes in energy related behaviours in students. The first objective of this explorative study was to identify determinants of physical activity and sedentary behaviour in Belgian university students. Secondly, we aimed to collect ideas and recommendations to increase physical activity and decrease sedentary behaviours in university students. Using a semi-structured question guide, seven focus group discussions were conducted consisting of 17 male and 29 female university students from a variety of study disciplines, with a mean age of 20.7 ± 1.6 yrs. Using Nvivo9, an inductive thematic approach was used for data analysis. Students reported that both physical and sedentary activities were influenced by individual factors (e.g. perceived enjoyment, self-discipline, time and convenience), their social networks (e.g. (lack of) parental control, modelling, social support), physical environment (e.g. availability and accessibility, travel time/distance, prices), and macro environment (e.g. media and advertising). Furthermore, the relationships between determinants and university students' physical activity and sedentary behaviour seemed to be moderated by university characteristics, such as residency, university lifestyle, exams and academic pressure. Recommendations for future physical activity interventions include improving information strategies regarding on-campus sports activities, cheaper and/or more flexible sports subscriptions and formulas, including 'sports time' into the curricula, and providing university bicycles around campus. Students also believed that increasing students' physical activity might decrease their sedentary behaviour at the same time. The recommendations and ideas discussed in this study may facilitate the development of effective and tailored (multilevel) intervention programs aiming to increase physical activity and decrease sedentary behaviours in university students.

  6. Pilot study to determine the feasibility of training Army National Guard medics to perform focused cardiac ultrasonography.

    Science.gov (United States)

    Backlund, Brandon H; Bonnett, Carl J; Faragher, Jeffrey P; Haukoos, Jason S; Kendall, John L

    2010-01-01

    To assess the ability of Army National Guard combat medics to perform a limited bedside echocardiography (BE) to determine cardiac activity after a brief training module. Twelve Army National Guard health care specialists trained to the level of emergency medical technician-basic (EMT-B) underwent an educational session consisting of a 5-minute lecture on BE followed by hands-on practical training. After the training session, each medic performed BEs, in either the subxiphoid (SX) or parasternal (PS) location at his or her discretion, on four healthy volunteers. The time required to complete the BE and the anatomic location of the examination (SX vs. PS) was documented. A 3-second video clip representing the best image was recorded for each BE. These clips were subsequently reviewed independently by two of the investigators with experience performing and interpreting BE; each BE was graded on a six-point scale designed for the study, the Cardiac Ultrasound Structural Assessment Scale (CUSAS). A score of 3 or greater was considered to be adequate to assess for the presence of cardiac activity. Where there was disagreement on the CUSAS score, the reviewers viewed the clip together and agreed on a consensus CUSAS score. We calculated the median time to completion and interquartile range (IQR) for each BE, the median CUSAS scores and IQR for examinations performed in the SX and PS locations, and kappa for agreement between the two reviewers on the CUSAS. A total of 48 BEs were recorded and reviewed. Thirty-seven of 48 (77%) were obtained in the SX location, and 11 of 48 (23%) were obtained in the PS location. Forty-four of 48 (92%) were scored as a 3 or higher on the CUSAS. Median time to completion of a BE was 5.5 seconds (IQR: 3.7-10.9 seconds). The median CUSAS score in the SX location was 4 (IQR: 4-5), and the median CUSAS score in the PS location was 4 (IQR: 4-4). Weighted kappa for the CUSAS was 0.6. With minimal training, the vast majority of the medics in our

  7. Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions.

    Science.gov (United States)

    Weber, Daniela; Davies, Michael J; Grune, Tilman

    2015-08-01

    Protein oxidation is involved in regulatory physiological events as well as in damage to tissues and is thought to play a key role in the pathophysiology of diseases and in the aging process. Protein-bound carbonyls represent a marker of global protein oxidation, as they are generated by multiple different reactive oxygen species in blood, tissues and cells. Sample preparation and stabilization are key steps in the accurate quantification of oxidation-related products and examination of physiological/pathological processes. This review therefore focuses on the sample preparation processes used in the most relevant methods to detect protein carbonyls after derivatization with 2,4-dinitrophenylhydrazine with an emphasis on measurement in plasma, cells, organ homogenates, isolated proteins and organelles. Sample preparation, derivatization conditions and protein handling are presented for the spectrophotometric and HPLC method as well as for immunoblotting and ELISA. An extensive overview covering these methods in previously published articles is given for researchers who plan to measure protein carbonyls in different samples.

  8. A Focus Group Assessment to Determine Motivations, Barriers and Effectiveness of a University-Based Worksite Wellness Program

    Directory of Open Access Journals (Sweden)

    Patricia E. Hill-Mey

    2013-12-01

    Full Text Available Background: This study explores university employee perceptions and under-standing about its Worksite Health Promotion Program (WHPP. The WHPP included a Health Risk Appraisal (HRA, biometric screening, publicity for on-campus health programs and facilities, and health coaching. Methods: A qualitative design was used based on a grounded theory approach. Four 90 minutes focus groups with 6-8 participants in each were con-ducted within a two 2 week period among employees, representing faculty/participants, faculty/nonparticipants, staff/participants, and staff/nonparticipants. Responses to questions about motivations, barriers, and perceived health benefits that impacted participation in the WHPP were digitally recorded, transcribed and coded for themes. Results: Incentives effectively motivated participation. Biometric screening had the largest impact on behavior change, followed by the information learned from the HRA. However, despite two-thirds of the employees participating in the program, lack of a full understanding of WHPP benefits and services lowered participation in follow-up services and supplemental pro-grams. Conclusions: Biometric screening and HRAs effectively motivate program participation. Communication of benefits and services are important when providing WHPPs.

  9. A focus group assessment to determine motivations, barriers and effectiveness of a university-based worksite wellness program.

    Science.gov (United States)

    Hill-Mey, Patricia E; Merrill, Ray M; Kumpfer, Karol L; Reel, Justine; Hyatt-Neville, Beverly

    2013-01-01

    This study explores university employee perceptions and under-standing about its Worksite Health Promotion Program (WHPP). The WHPP included a Health Risk Appraisal (HRA), biometric screening, publicity for on-campus health programs and facilities, and health coaching. A qualitative design was used based on a grounded theory ap-proach. Four 90 minutes focus groups with 6-8 participants in each were conducted within a two 2 week period among employees, representing fac-ulty/participants, fac-ulty/nonparticipants, staff/participants, and staff/nonparticipants. Responses to questions about motivations, barriers, and perceived health benefits that impacted participation in the WHPP were digi-tally recorded, transcribed and coded for themes. Incentives effectively motivated participation. Biometric screening had the largest impact on behavior change, followed by the information learned from the HRA. However, despite two-thirds of the employees partici-pating in the pro-gram, lack of a full understanding of WHPP benefits and services lowered partici-pation in follow-up services and supplemental pro-grams. Biometric screening and HRAs effectively motivate program par-ticipation. Communication of benefits and services are important when providing WHPPs.

  10. Characterization of Some Real Mixed Plastics from WEEE: A Focus on Chlorine and Bromine Determination by Different Analytical Methods

    Directory of Open Access Journals (Sweden)

    Beatrice Beccagutti

    2016-10-01

    Full Text Available Bromine and chlorine are almost ubiquitous in waste of electrical and electronic equipment (WEEE and the knowledge of their content in the plastic fraction is an essential step for proper end of life management. The aim of this study is to compare the following analytical methods: energy dispersive X-ray fluorescence spectroscopy (ED-XRF, ion chromatography (IC, ion-selective electrodes (ISEs, and elemental analysis for the quantitative determination of chlorine and bromine in four real samples taken from different WEEE treatment plants, identifying the best analytical technique for waste management workers. Home-made plastic standard materials with known concentrations of chlorine or bromine have been used for calibration of ED-XRF and to test the techniques before the sample analysis. Results showed that IC and ISEs, based upon dissolution of the products of the sample combustion, have not always achieved a quantitative absorption of the analytes in the basic solutions and that bromine could be underestimated since several oxidation states occur after combustion. Elemental analysis designed for chlorine determination is subjected to strong interference from bromine and required frequent regeneration and recalibration of the measurement cell. The most reliable method seemed to be the non-destructive ED-XRF. Calibration with home-made standards, having a similar plastic matrix of the samples, enabled us to carry out quantitative determinations, which have been revealed to be satisfactorily accurate and precise. In all the analyzed samples a total concentration of chlorine and/or bromine between 0.6 and 4 w/w% was detected, compromising the feasibility of a mechanical recycling and suggesting the exploration of an alternative route for managing these plastic wastes.

  11. Sample Size Determination Within the Scope of Conditional Maximum Likelihood Estimation with Special Focus on Testing the Rasch Model.

    Science.gov (United States)

    Draxler, Clemens; Alexandrowicz, Rainer W

    2015-12-01

    This paper refers to the exponential family of probability distributions and the conditional maximum likelihood (CML) theory. It is concerned with the determination of the sample size for three groups of tests of linear hypotheses, known as the fundamental trinity of Wald, score, and likelihood ratio tests. The main practical purpose refers to the special case of tests of the class of Rasch models. The theoretical background is discussed and the formal framework for sample size calculations is provided, given a predetermined deviation from the model to be tested and the probabilities of the errors of the first and second kinds.

  12. Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure.

    Science.gov (United States)

    Vildhede, Anna; Wiśniewski, Jacek R; Norén, Agneta; Karlgren, Maria; Artursson, Per

    2015-08-07

    Freshly isolated human hepatocytes are considered the gold standard for in vitro studies of liver functions, including drug transport, metabolism, and toxicity. For accurate predictions of the in vivo outcome, the isolated hepatocytes should reflect the phenotype of their in vivo counterpart, i.e., hepatocytes in human liver tissue. Here, we quantified and compared the membrane proteomes of freshly isolated hepatocytes and human liver tissue using a label-free shotgun proteomics approach. A total of 5144 unique proteins were identified, spanning over 6 orders of magnitude in abundance. There was a good global correlation in protein abundance. However, the expression of many plasma membrane proteins was lower in the isolated hepatocytes than in the liver tissue. This included transport proteins that determine hepatocyte exposure to many drugs and endogenous compounds. Pathway analysis of the differentially expressed proteins confirmed that hepatocytes are exposed to oxidative stress during isolation and suggested that plasma membrane proteins were degraded via the protein ubiquitination pathway. Finally, using pitavastatin as an example, we show how protein quantifications can improve in vitro predictions of in vivo liver clearance. We tentatively conclude that our data set will be a useful resource for improved hepatocyte predictions of the in vivo outcome.

  13. Without 'Focus'

    Directory of Open Access Journals (Sweden)

    Aldo Sevi

    2010-12-01

    Full Text Available It is widely accepted that a notion of 'focus', more or less as conceived of in Jackendoff (1972, must be incorporated into our theory of grammar, as a means of accounting for certain observed correlations between prosodic facts and semantic/pragmatic facts. In this paper, we put forth the somewhat radical idea that the time has come to give up this customary view, and eliminate 'focus' from our theory of grammar. We argue that such a move is both economical and fruitful.Research over the years has revealed that the correlations between prosody, 'focus', and the alleged semantic/pragmatic effects of focus are much less clear and systematic than we may have initially hoped. First we argue that this state of affairs detracts significantly from the utility of our notion of 'focus', to the point of calling into question the very motivation for including it in the grammar. Then we look at some of the central data, and show how they might be analyzed without recourse to a notion of 'focus'. We concentrate on (i the effect of pitch accent placement on discourse congruence, and (ii the choice of 'associate' for the so-called 'focus sensitive' adverb only. We argue that our focus-free approach to the data improves empirical coverage, and begins to reveal patterns that have previously been obscured by preconceptions about 'focus'.ReferencesBeaver, D. & Clark, B. 2008. Sense and Sensitivity: How Focus Determines Meaning. Blackwell.Beaver, D., Clark, B., Flemming, E., Jaeger, T. F. & Wolters, M. 2007. ‘When semantics meets phonetics: Acoustical studies of second occurrence focus’. Language 83.2: 245–76.http://dx.doi.org/10.1353/lan.2007.0053Beckman, M. & Hirschberg, J. 1994. ‘The ToBI Annotation Conventions’. Ms.,http://www.cs.columbia.edu/~julia/files/conv.pdf.Bolinger, D. 1972. ‘Accent is predictable (if you are a mind-reader’. Language 48.3: 633–44.http://dx.doi.org/10.2307/412039Büring, D. 2006. ‘Focus projection and default

  14. The use of environmental tracers to determine focused recharge from a saline disposal basin and irrigation channels in a semiarid environment in Southeastern Australia

    Science.gov (United States)

    Robson, T. C.; Webb, J. A.

    2016-07-01

    Lake Tutchewop in southeastern Australia is a former ephemeral wetland that has been used as a saline disposal basin since 1968, forming part of the salinity management of the Murray River. The extent of saline focused recharge from Lake Tutchewop and fresh recharge from nearby unlined irrigation channels was determined using pore water and groundwater stable isotope and major ion chemistry, which were able to separate the influence of lake water, irrigation water and regional groundwater. In ∼45 years, saline water from Lake Tutchewop has infiltrated only up to 165 m from the lake edge in most directions, due to the underlying relatively impermeable clay-rich sediments, and a maximum of 700 m due to preferential groundwater flow along a sandy palaeochannel. The saline leakage has had limited, if any, impact on surrounding agricultural land use. Fresh water leakage from unlined irrigation channels extends up to 10 m deep, validating the current program to replace these channels with pipelines. This study demonstrates that focused recharge from different sources can be positively identified where the recharge waters have distinctive compositions, and that underlying clay-rich sediments restrict the extent of seepage. Therefore, management of focused recharge sources, particularly those that could decrease groundwater quality, requires a detailed knowledge of both the groundwater composition around the site and the underlying geology.

  15. Tandem focused ultrasound (TFU) combined with fast furnace analysis as an improved methodology for total mercury determination in human urine by electrothermal-atomic absorption spectrometry.

    Science.gov (United States)

    Capelo, J L; Dos Reis, C D; Maduro, C; Mota, A

    2004-09-01

    A new sample preparation procedure based on tandem (that is, different diameter probe sonicators used in the same sample treatment) focused ultrasound (TFU) for mercury separation, preconcentration and back-extraction in aqueous solution from human urine has been developed. The urine is first oxidized with KMnO(4)/HCl/focused ultrasound (6mm probe). Secondly, the mercury is extracted and preconcentrated with dithizone and cyclohexane. Finally, the mercury is back-extracted and preconcentrated again with the aid of focused ultrasound (3mm probe). The procedure allows determining mercury by electrothermal atomic absorption spectrometry with fast furnace analysis and calibration against aqueous standards. Matrix modification is provided by the chemicals used in the sample treatment. The procedure is accomplished with low sample volume (8.5ml). Low volume and low concentration reagents are used. The sample treatment is rapid (less than 3min per sample) and avoids the use of organic phase in the graphite furnace. The preconcentration factor used in this work was 14. The limit of detection and the limit of quantification in urine were, respectively, 0.27 and 0.9mugl(-1). The relative standard deviation of aqueous standards (n=10) was 4% for a concentration of 100mugl(-1) and 5% for a concentration of 400mugl(-1). Recoveries from spiked urine with inorganic mercury, methyl-mercury, phenyl-mercury and diphenyl-mercury ranged from 86 to 98%.

  16. An improved facile method for extraction and determination of steroidal saponins in Tribulus terrestris by focused microwave-assisted extraction coupled with GC-MS.

    Science.gov (United States)

    Li, Tianlin; Zhang, Zhuomin; Zhang, Lan; Huang, Xinjian; Lin, Junwei; Chen, Guonan

    2009-12-01

    An improved fast method for extraction of steroidal saponins in Tribulus terrestris based on the use of focus microwave-assisted extraction (FMAE) is proposed. Under optimized conditions, four steroidal saponins were extracted from Tribulus terrestris and identified by GC-MS, which are Tigogenin (TG), Gitogenin (GG), Hecogenin (HG) and Neohecogenin (NG). One of the most important steroidal saponins, namely TG was quantified finally. The recovery of TG was in the range of 86.7-91.9% with RSDTribulus terrestris from different areas of occurrence. The difference in chromatographic characteristics of steroidal saponins was proved to be related to the different areas of occurrence. The results showed that FMAE-GC-MS is a simple, rapid, solvent-saving method for the extraction and determination of steroidal saponins in Tribulus terrestris.

  17. Focused ultrasound solid-liquid extraction and selective pressurised liquid extraction to determine bisphenol A and alkylphenols in sewage sludge by gas chromatography-mass spectrometry.

    Science.gov (United States)

    Martínez-Moral, María P; Tena, María T

    2011-09-01

    A new method for determining endocrine disrupter compounds (EDCs) in sewage sludge is described in this paper. EDCs studied were bisphenol A (BPA) and alkylphenols (APs). In order to obtain a fast and simple method, selective pressurised liquid extraction (SPLE) and focused ultrasound solid-liquid extraction (FUSLE) were tested. Best results for SPLE were obtained using Florisil as clean-up sorbent and dichloromethane as extraction solvent, while temperature was the only significant variable. Analyte extraction by SPLE was completed in only one extraction cycle of 1 min at 130 °C. FUSLE was carried out in one step of 20 s at 75% power (0.5 cycles) and with 8 mL of ethyl acetate. Although the optimised FUSLE process was faster, simpler and cheaper, SPLE provided higher recovery values (ranging from 81 to 105%) and therefore SPLE-based method was selected and validated. The SPLE and GC-MS method showed an LOD of 10.7 ng/g for BPA and LODs between 1.2 and 41.6 ng/g for APs. Relative standard deviation values lower than 6% were obtained for all analytes. As a result, an efficient, fast and simple method based on SPLE and GC-MS for the determination of BPA and APs in sewage sludge is proposed.

  18. Optimization of an open-focused microwave oven digestion procedure for determination of metals in diesel oil by inductively coupled plasma optical emission spectrometry.

    Science.gov (United States)

    Sant'Ana, Flavio W; Santelli, Ricardo E; Cassella, Alessandra R; Cassella, Ricardo J

    2007-10-01

    This work reports the optimization of a focused microwave assisted procedure for the wet acid dissolution of diesel oil in order to allow the determination of metals in the samples by inductively coupled plasma optical emission spectrometry (ICP-OES). The dissolution process was monitored by measuring residual carbon content (RCC), also by ICP-OES, in the final solutions obtained after application of digestion program. All experimental work was performed using a commercial sample of diesel oil containing 85.74+/-0.13% of carbon. The initial dissolution program comprised three steps: (i) carbonization with H(2)SO(4); (ii) oxidation with HNO(3) and (iii) final oxidation with H(2)O(2). During work it was verified that the first step played an important role on the dissolution process of this kind of sample. It is therefore, necessary to give a detailed optimization of such step. Employing the optimized conditions it was possible to digest 2.5 g of diesel oil with a 40 min-heating program. At these conditions, residual carbon content was always lower than 5%. Optimized methodology was applied in the determination of metals in three diesel oil samples by ICP-OES. Recovery tests were also performed by adding 10 microg of metals, as organic standards, to the samples before digestion. Recovery percentages always higher than 90% were obtained for the metals of interest (Al, Cu, Fe and Ni), except for Zn, which presented recoveries between 70 and 78%.

  19. Determination of caffeoylquinic acids in feed and related products by focused ultrasound solid-liquid extraction and ultra-high performance liquid chromatography-mass spectrometry.

    Science.gov (United States)

    Tena, M T; Martínez-Moral, M P; Cardozo, P W

    2015-06-26

    A method to determine caffeoylquinic acids (CQAs) in three sources (herbal extract, feed additive and finished feed) using for the first time focused ultrasound solid-liquid extraction (FUSLE) followed by ultra-high performance liquid chromatography (UPLC) coupled to quadrupole-time of flight mass spectrometry is presented. Pressurized liquid extraction (PLE) was also tested as extraction technique but it was discarded because cynarin was not stable under temperature values used in PLE. The separation of the CQAs isomers was carried out in only seven minutes. FUSLE variables such as extraction solvent, power and time were optimized by a central composite design. Under optimal conditions, FUSLE extraction was performed with 8mL of an 83:17 methanol-water mixture for 30s at a power of 60%. Only two extraction steps were found necessary to recover analytes quantitatively. Sensitivity, linearity, accuracy and precision were established. Matrix effect was studied for each type of sample. It was not detected for mono-CQAs, whereas the cynarin signal was strongly decreased due to ionization suppression in presence of matrix components; so the quantification by standard addition was mandatory for the determination of di-caffeoylquinic acids. Finally, the method was applied to the analysis of herbal extracts, feed additives and finished feed. In all samples, chlorogenic acid was the predominant CQA, followed by criptochlorogenic acid, neochlorogenic acid and cynarin. The method allows an efficient determination of chlorogenic acid with good recovery rates. Therefore, it may be used for screening of raw material and for process and quality control in feed manufacture.

  20. Ion focusing

    Energy Technology Data Exchange (ETDEWEB)

    Cooks, Robert Graham; Baird, Zane; Peng, Wen-Ping

    2017-01-17

    The invention generally relates to apparatuses for focusing ions at or above ambient pressure and methods of use thereof. In certain embodiments, the invention provides an apparatus for focusing ions that includes an electrode having a cavity, at least one inlet within the electrode configured to operatively couple with an ionization source, such that discharge generated by the ionization source is injected into the cavity of the electrode, and an outlet. The cavity in the electrode is shaped such that upon application of voltage to the electrode, ions within the cavity are focused and directed to the outlet, which is positioned such that a proximal end of the outlet receives the focused ions and a distal end of the outlet is open to ambient pressure.

  1. Rapid analytical method for the determination of pesticide residues in sunflower seeds based on focused microwave-assisted Soxhlet extraction prior to gas chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Prados-Rosales, R C; Luque García, J L; Luque de Castro, M D

    2003-04-18

    A rapid analytical method for determination of organochlorine pesticide residues in sunflower seeds based on focused microwave-assisted Soxhlet extraction has been developed. The main factors affecting the extraction efficiency--namely microwave power, irradiation time, volume of extractant and number of cycles--were optimized by a two-level factorial fractional design. After extraction, a liquid-liquid extraction and a clean-up step including the use of Florisil macrocolumns were required prior to injection of the extracts into the chromatograph in order to isolate the pesticide residues from the lipid fraction of the original extract. The MS-MS ion preparation mode was selected due to the high sensitivity and selectivity it provides. Seed samples were used collected near a crop subjected to aerial pesticide application. Residues of hexachlorocyclohexane isomers and endosulfan were found in the seeds although they were not subjected to pesticide application, thus showing the spray-drift contamination. The validation of the proposed approach was carried out by comparison with the ISO 659-1988 reference extraction method obtaining similar, or even better efficiencies by the proposed approach.

  2. Anemia and its determinants among women of reproductive age of a slum in Kolkata: A focus group discussion among health workers in a slum of Kolkata.

    Science.gov (United States)

    Dasgupta, Aparajita; Sarkar, Kaushik; Chowdhury, Ranadip; Ray, Arindam; Shahbabu, Bhaskar

    2016-01-01

    Anemia is a major contributor to morbidity and mortality among women of reproductive age. Progress toward reducing the burden of anemia has been little despite efforts through decades. We conducted this study to unearth the microlevel determinants of anemia among women of reproductive age. This qualitative study was conducted in Urban Health Centre (UHC), Chetla. A focus group discussion was held among all the eight health staffs, who were involved in reproductive and child health-related service delivery under UHC, Chetla. A thematic analysis of the transcript was performed. We found that socioeconomic factors like poverty and social neglect, diet and nutrition related factors, lack of personal hygiene, and worm infestation contributed to the burden of anemia, and this was reinforced by factors related to service delivery, such as lack of supply of drugs and supplements, and inadequate training of health workers as well as poor media accountability. Because of easy reversibility and implementation, health service delivery-related issues should be addressed closely through monitoring and evaluation and appropriate and timely action should be taken to improve the effectiveness of the services.

  3. 河南省小麦纹枯病菌的群体组成及其致病力分化研究%Composition and virulence variation of the pathogen of wheat sharp eyespot from Henan Province

    Institute of Scientific and Technical Information of China (English)

    汪敏; 吕柏林; 邢小萍; 李洪连

    2011-01-01

    To make sure of composition and virulence variation of the pathogen of wheat sharp eyespot from Henan Province, 157 Rhizoctonia strains were isolated from 13 districts in Henan in 2008 and 2009. All of the isolates were binucleate Rhizoctonia strains (BNR) identified by the nuclear staining. 156 isolates were belonged to the binucleate Rhizoctonia AG-D anastomosis group and 1 was the AG-BO group through hyphal anastomosis reaction and rDNA-ITS sequences analysis. The virulence of 113 isolates were tested in greenhouse on 3 wheat cultivars such as Ji 5385 , Shan 229 and Yumai 49. The virulence of Rhizoctonia isolates showed significant difference,and it could be divided into three pathotypes:the highly, moderately and weakly aggressive isolates,accounting for 58.40% ,35.40% and 6. 19% , respectively. The results indicated that the virulence of isolates had certain difference among the 13 different regions, the isolates from Hebi, Zhoukou and Luohe regeins showed strong virulence, whereas that from Xinyang region showed weak virulence. The virulence of Rhizoctonia isolates on 3 wheat cultivars also had significant difference, the strong virulence on Shan 229 and weak virulence on Ji 5385.%纹枯病已成为我国小麦生产的主要障碍之一.许多学者研究表明,我国小麦纹枯病菌优势菌群为禾谷丝核菌(Rhizoctonia cerealis),其中主要为AG-D融合群,其次还包括AG-A、AG-R、AG-E、AG-Bo融合群和立枯丝核菌(R.solani)的AG-2、AG-4及AG-5融合群等[1].

  4. Determination of endocrine disrupting compounds in fish liver, brain, and muscle using focused ultrasound solid-liquid extraction and dispersive solid phase extraction as clean-up strategy.

    Science.gov (United States)

    Ros, Oihana; Vallejo, Asier; Olivares, Maitane; Etxebarria, Nestor; Prieto, Ailette

    2016-08-01

    This study describes a new method for the simultaneous extraction of several endocrine disrupting compounds, including alkylphenols (APs), estrogen, bisphenol-A (BPA) and one phthalate metabolite (mono-2-ethylhexyl ester, MEHP) in fish liver, brain, and muscle. Parameters affecting the extraction (extraction solvent and temperature) and the clean-up (dispersive phase nature and amount) steps were evaluated. The extraction was performed by means of focused ultrasound solid-liquid extraction (FUSLE) using 10 mL of n-hexane:acetone (50:50, v/v) for 5 min at ~0 °C, and the clean-up was done by means of dispersive solid phase extraction (dSPE) using 100 mg of ENVI-CARB and 100 mg of MgSO4 for the cleaning of brain and muscle extracts together with 100 mg of PSA in the case of liver extracts. Good apparent recoveries were obtained in the case of liver (62-132 %), brain (66-120 %), and muscle (74-129 %), relative standard deviation (RSD%) was always below 26 %, and the method detection limits (MDLs) were at low ng/g level. The developed method was applied to fish captured in Urdaibai estuary (Bay of Biscay) in December 2015, and the concentrations obtained were in the range MDL-1115 ng/g in brain, MDL-962 ng/g in muscle, and MDL-672 ng/g in liver. In general, the highest concentrations were measured in liver, followed by brain and muscle. In addition, diethylstilbestrol was only detected in fish brain. Graphical Abstract MS method scheme for the/MS method scheme for the determination of EDCs in fish liver, brain and muscle.

  5. Focus: Digital

    DEFF Research Database (Denmark)

    Technology has been an all-important and defining element within the arts throughout the 20th century, and it has fundamentally changed the ways in which we produce and consume music. With this Focus we investigate the latest developments in the digital domain – and their pervasiveness and rapid...... production and reception of contemporary music and sound art. With ‘Digital’ we present four composers' very different answers to how technology impact their work. To Juliana Hodkinson it has become an integral part of her sonic writing. Rudiger Meyer analyses the relationships between art and design and how...

  6. Focusing horn

    CERN Multimedia

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet.For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  7. Determining temperature distribution in tissue in the focal plane of the high (>100 W/cm(2)) intensity focused ultrasound beam using phase shift of ultrasound echoes.

    Science.gov (United States)

    Karwat, Piotr; Kujawska, Tamara; Lewin, Peter A; Secomski, Wojciech; Gambin, Barbara; Litniewski, Jerzy

    2016-02-01

    In therapeutic applications of High Intensity Focused Ultrasound (HIFU) the guidance of the HIFU beam and especially its focal plane is of crucial importance. This guidance is needed to appropriately target the focal plane and hence the whole focal volume inside the tumor tissue prior to thermo-ablative treatment and beginning of tissue necrosis. This is currently done using Magnetic Resonance Imaging that is relatively expensive. In this study an ultrasound method, which calculates the variations of speed of sound in the locally heated tissue volume by analyzing the phase shifts of echo-signals received by an ultrasound scanner from this very volume is presented. To improve spatial resolution of B-mode imaging and minimize the uncertainty of temperature estimation the acoustic signals were transmitted and received by 8 MHz linear phased array employing Synthetic Transmit Aperture (STA) technique. Initially, the validity of the algorithm developed was verified experimentally in a tissue-mimicking phantom heated from 20.6 to 48.6 °C. Subsequently, the method was tested using a pork loin sample heated locally by a 2 MHz pulsed HIFU beam with focal intensity ISATA of 129 W/cm(2). The temperature calibration of 2D maps of changes in the sound velocity induced by heating was performed by comparison of the algorithm-determined changes in the sound velocity with the temperatures measured by thermocouples located in the heated tissue volume. The method developed enabled ultrasound temperature imaging of the heated tissue volume from the very inception of heating with the contrast-to-noise ratio of 3.5-12 dB in the temperature range 21-56 °C. Concurrently performed, conventional B-mode imaging revealed CNR close to zero dB until the temperature reached 50 °C causing necrosis. The data presented suggest that the proposed method could offer an alternative to MRI-guided temperature imaging for prediction of the location and extent of the thermal lesion prior to applying the

  8. The Influence of Information Structure on the Depth of Semantic Processing: How Focus and Pitch Accent Determine the Size of the N400 Effect

    Science.gov (United States)

    Wang, Lin; Bastiaansen, Marcel; Yang, Yufang; Hagoort, Peter

    2011-01-01

    To highlight relevant information in dialogues, both wh-question context and pitch accent in answers can be used, such that focused information gains more attention and is processed more elaborately. To evaluate the relative influence of context and pitch accent on the depth of semantic processing, we measured event-related potentials (ERPs) to…

  9. Patient-based outcome analysis is important to determine the success of total knee arthroplasty: result of a focus group discussion

    Directory of Open Access Journals (Sweden)

    Zacharia B

    2016-05-01

    Full Text Available Balaji Zacharia, Manu Paul, Mohammed Thanveeruddin Sherule Department of Orthopedics, Government Medical College, Kozhikode, Kerala, India Background: Total knee replacement (TKR results in an excellent outcome in terms of pain relief. The reporting of outcomes was traditionally focused on implant survivorship and objective outcomes such as range of motion, knee stability, and radiographic alignment. However, patients and doctors had differing perceptions of all domains of outcome, especially subjective quality of life domains such as emotions and social functioning. In this study, we tried to find out the expectations of Indian patients regarding TKR and assess the level of satisfaction among our patients from their view point using focus group discussion (FGD, and whether these expectations have an impact on outcomes and patient satisfaction. Materials and methods: This study was conducted in the Department of Orthopedics, Government Medical College, Kozhikode, Kerala, India, in November 2014. Patients between the ages 60 and 65 years who met inclusion criteria were selected. A total of 50 patients were selected for FGDs. Among them, 42 patients participated in FGD. The remaining eight did not appear for the discussion. A total of four FGD sessions were conducted. Results and discussion: It was found that there is a discrepancy between the satisfaction levels of patient and surgeon. There is a difference in satisfaction level achieved depending on socioeconomic, geographic, and cultural characteristics. Conclusion: Newer methods of TKR outcome assessment combining radiological outcome, surgeon-based assessment, and patient satisfaction based on their socioeconomic status and cultural characteristics should be developed for different populations. Keywords: focus group discussion, total knee arthroplasty, patient-specific objectives

  10. Patient-based outcome analysis is important to determine the success of total knee arthroplasty: result of a focus group discussion.

    Science.gov (United States)

    Zacharia, Balaji; Paul, Manu; Thanveeruddin Sherule, Mohammed

    2016-01-01

    Total knee replacement (TKR) results in an excellent outcome in terms of pain relief. The reporting of outcomes was traditionally focused on implant survivorship and objective outcomes such as range of motion, knee stability, and radiographic alignment. However, patients and doctors had differing perceptions of all domains of outcome, especially subjective quality of life domains such as emotions and social functioning. In this study, we tried to find out the expectations of Indian patients regarding TKR and assess the level of satisfaction among our patients from their view point using focus group discussion (FGD), and whether these expectations have an impact on outcomes and patient satisfaction. This study was conducted in the Department of Orthopedics, Government Medical College, Kozhikode, Kerala, India, in November 2014. Patients between the ages 60 and 65 years who met inclusion criteria were selected. A total of 50 patients were selected for FGDs. Among them, 42 patients participated in FGD. The remaining eight did not appear for the discussion. A total of four FGD sessions were conducted. It was found that there is a discrepancy between the satisfaction levels of patient and surgeon. There is a difference in satisfaction level achieved depending on socioeconomic, geographic, and cultural characteristics. Newer methods of TKR outcome assessment combining radiological outcome, surgeon-based assessment, and patient satisfaction based on their socioeconomic status and cultural characteristics should be developed for different populations.

  11. Determining

    Directory of Open Access Journals (Sweden)

    Bahram Andarzian

    2015-06-01

    Full Text Available Wheat production in the south of Khuzestan, Iran is constrained by heat stress for late sowing dates. For optimization of yield, sowing at the appropriate time to fit the cultivar maturity length and growing season is critical. Crop models could be used to determine optimum sowing window for a locality. The objectives of this study were to evaluate the Cropping System Model (CSM-CERES-Wheat for its ability to simulate growth, development, grain yield of wheat in the tropical regions of Iran, and to study the impact of different sowing dates on wheat performance. The genetic coefficients of cultivar Chamran were calibrated for the CSM-CERES-Wheat model and crop model performance was evaluated with experimental data. Wheat cultivar Chamran was sown on different dates, ranging from 5 November to 9 January during 5 years of field experiments that were conducted in the Khuzestan province, Iran, under full and deficit irrigation conditions. The model was run for 8 sowing dates starting on 25 October and repeated every 10 days until 5 January using long-term historical weather data from the Ahvaz, Behbehan, Dezful and Izeh locations. The seasonal analysis program of DSSAT was used to determine the optimum sowing window for different locations as well. Evaluation with the experimental data showed that performance of the model was reasonable as indicated by fairly accurate simulation of crop phenology, biomass accumulation and grain yield against measured data. The normalized RMSE were 3%, 2%, 11.8%, and 3.4% for anthesis date, maturity date, grain yield and biomass, respectively. Optimum sowing window was different among locations. It was opened and closed on 5 November and 5 December for Ahvaz; 5 November and 15 December for Behbehan and Dezful;and 1 November and 15 December for Izeh, respectively. CERES-Wheat model could be used as a tool to evaluate the effect of sowing date on wheat performance in Khuzestan conditions. Further model evaluations

  12. Comparison of Apolipoprotein (apoB/apoA-I) and Lipoprotein (Total Cholesterol/HDL) Ratio Determinants. Focus on Obesity, Diet and Alcohol Intake

    Science.gov (United States)

    Tognon, Gianluca; Berg, Christina; Mehlig, Kirsten; Thelle, Dag; Strandhagen, Elisabeth; Gustavsson, Jaana; Rosengren, Annika; Lissner, Lauren

    2012-01-01

    The ratio between apolipoprotein B and apolipoprotein A-I (apoB/apoA-I) has been suggested to be a powerful and more accurate predictor of future cardiovascular disease risk than total cholesterol and HDL cholesterol. Since diet and lifestyle can directly influence dyslipidemia, it is of interest to identify modifiable factors that are associated with high levels of the apolipoprotein ratio and if they can have a different association with a more traditional indicator of cardiovascular risk such as total cholesterol/HDL. The relationship between obesity and dyslipidemia is established and it is of interest to determine which factors can modify this association. This study investigated the cross-sectional association of obesity, diet and lifestyle factors with apoB/apoA-I and total cholesterol/HDL respectively, in a Swedish population of 2,907 subjects (1,537 women) as part of the INTERGENE study. The apolipoprotein and lipoprotein ratios were highly correlated, particularly in women, and obesity was strongly associated with both. Additionally, age, cigarette smoking and alcohol intake were important determinants of these ratios. Alcohol was the only dietary factor that appreciably attenuated the association between obesity and each of the ratios, with a stronger attenuation in women. Other dietary intake and lifestyle-related factors such as smoking status and physical activity had a lower effect on this association. Because the apolipoprotein and lipoprotein ratios share similar diet and lifestyle determinants as well as being highly correlated, we conclude that either of these ratios may be a sufficient indicator of dyslipidemia. PMID:22848405

  13. Labour market risks and institutional determinants: an international comparative study of institutions and non-standard employment with a focus on East Asia

    OpenAIRE

    Lee, Sophia Seung-Yoon; Walker, Robert; Coleman, David

    2011-01-01

    Korea and Japan stand out in the group of OECD countries for their rapid increase in, and high levels of, non-standard employment. The empirical evidence leads us to a two-part puzzle: Why are there so many precarious workers in Korea and Japan? And what are the institutional determinants of such labour market risks? This thesis commences by introducing the concept of 'risk shift', and the fuzzy-set ideal type approach is employed to conduct a comparative study of 18 countries. The labour mar...

  14. Focused-microwave-assisted reaction in flow injection spectrophotometry: a new liquid-vapor separation chamber for determination of reducing sugars in wine.

    Science.gov (United States)

    Oliveira, A F; Fatibello-Filho, O; Nóbrega, J A

    2001-10-31

    The usefulness of an unsegmented liquid/vapor phases flow injection system for determining reducing sugars in wines using a focalized poly(tetrafluoroethylene) (PTFE) coiled reactor positioned at the output antenna of a domestic microwave oven at 700 W is demonstrated. In this system, sample or reference solution is mixed to 2.5 mol l(-1) sodium hydroxide and 6.8 mmol l(-1) potassium hexacyanoferrate(III) solutions previously merged in a confluence point and the reducing sugars (glucose plus fructose) were oxidized by potassium hexacyanoferrate(III) solution into the PTFE coiled reactor positioned in the microwave oven cavity. After phases separation at a proposed separation chamber (SC), the decrease of K(3)Fe(CN)(6) concentration in the liquid phase was measured at 420 nm. Using this SC, a favorable dispersion profile and a decrease of hydrodynamic pressure were observed. The flow procedure presented similar sensitivities to glucose and fructose in the experimental conditions adopted, allowing the determination of the reducing sugars content (fructose plus glucose concentrations) in the concentration range from 40 to 400 mumol l(-1) with a detection limit of 9 mumol l(-1). The RSD was 1.9% for a 120 mumol l(-1) fructose solution (n=12) and the analytical frequency was 54 h(-1). The results obtained for reducing sugars in several wines using the proposed flow system and those obtained using the Somogyi-Nelson batch procedure were in agreement at the 95% confidence level.

  15. Determinantes do comportamento alimentar: uma revisão com enfoque na família Determinants of eating behavior: a review focusing on the family

    Directory of Open Access Journals (Sweden)

    Alessandra Rossi

    2008-12-01

    Full Text Available O comportamento alimentar ocupa atualmente um papel central na prevenção e no tratamento de doenças. A alimentação durante a infância, ao mesmo tempo em que é importante para o crescimento e desenvolvimento, pode também representar um dos principais fatores de prevenção de algumas doenças na fase adulta. Freqüentemente a família, os fatores sociais e os ambientais podem influenciar o padrão alimentar das crianças. O objetivo desta revisão foi abordar os diversos fatores ambientais envolvidos na aquisição de hábitos alimentares na infância. Os artigos selecionados foram pesquisados nas bases de dados Medline e SciELO considerando o período de 1978 a 2007. Foram utilizados os termos em ingles: children's eating patterns, children's dietary quality, determinants of children's eating patterns e em português. São apresentados os resultados de algumas investigações mais relevantes nesta área. Embora alguns desses fatores sejam inatos e, por isso, necessitem de um controle mais rigoroso, ressalta-se o papel determinante da família na formação dos hábitos alimentares saudáveis, pois a modificação de um hábito alimentar durante a fase adulta tem, em geral, alta taxa de insucesso. Além disso, outros fatores, como a escola, a rede social, as condições socioeconômicas e culturais, são potencialmente modificáveis e influenciam no processo de construção dos hábitos alimentares da criança e, conseqüentemente, do indivíduo adulto.Eating behavior currently has a central role in the prevention and treatment of illnesses. Eating patterns during childhood, while important for growth and development, also represent one of the main factors that can prevent diseases in adulthood. Such eating patterns are frequently influenced by family, social and environmental factors. The objective of this review was to approach the many environmental factors involved in the acquisition of eating habits during childhood. The selected

  16. Model Estimates Of Gross Domestic Product In Relation to Export And Import Of Fuels, Focused on the Elasticity and Determination Of Directly and Indirectly Associated Rates

    Directory of Open Access Journals (Sweden)

    Gheorghe Săvoiu

    2016-03-01

    Full Text Available The article is based on several interrogative assumptions related to the positive impact of the crises and the recession on determinations in the econometric models of Romania’s GDP as a variable dependent in relation to the export and import of fuels. After a short introductory section, which details, in a relative manner, the overall goal and the objectives of the paper, a first section makes use of elasticity and the modern solutions of building the coefficient of elasticity, proposing an original alternative to existing variants, and afterwards the next section builds on these statistical tools in the econometric modeling of Romania’s GDP, starting from the ratios and value indicators and offering a few original models where the export and import of fuels are the key initial explanatory factors. The final remarks reinterpret the role of the energy resources, as well as that of the related flows, in enhancing statistical connections, and especially the role of crises and recessions in validating econometric models, by raising their degree of predictability.

  17. Method for the determination of the modulation transfer function (MTF) in 3D x-ray imaging systems with focus on correction for finite extent of test objects

    Science.gov (United States)

    Schäfer, Dirk; Wiegert, Jens; Bertram, Matthias

    2007-03-01

    It is well known that rotational C-arm systems are capable of providing 3D tomographic X-ray images with much higher spatial resolution than conventional CT systems. Using flat X-ray detectors, the pixel size of the detector typically is in the range of the size of the test objects. Therefore, the finite extent of the "point" source cannot be neglected for the determination of the MTF. A practical algorithm has been developed that includes bias estimation and subtraction, averaging in the spatial domain, and correction for the frequency content of the imaged bead or wire. Using this algorithm, the wire and the bead method are analyzed for flat detector based 3D X-ray systems with the use of standard CT performance phantoms. Results on both experimental and simulated data are presented. It is found that the approximation of applying the analysis of the wire method to a bead measurement is justified within 3% accuracy up to the first zero of the MTF.

  18. Novel on-line column extraction apparatus coupled with binary peak focusing for high-performance liquid chromatography determination of rifampicin in human plasma: a strategy for therapeutic drug monitoring.

    Science.gov (United States)

    Li, Wei; Peng, Min; Long, Minghui; Qiu, Ximin; Yang, Liping

    2014-12-01

    In order to develop a method that is completely suitable for the routine therapeutic drug monitoring, a sensitive and fully automated on-line column extraction apparatus in combination with high-performance liquid chromatography allowing binary peak focusing was developed and validated for the determination of rifampicin in human plasma. Rifapentine was used as an internal standard. The analytical cycle started with the injection of 100 μL of the sample pretreated by protein precipitation in a Venusil SCX extraction column. After the elution, the analytes were transferred and concentrated in an Xtimate C18 trap column. Finally, the trapped analytes were separated by an Xtimate C18 analytical column and were analyzed by an ultraviolet detector at 336 nm. With this new strategy, continuous on-line analysis of the compounds was successfully performed. The method showed excellent performance for the analysis of rifampicin in plasma samples, including calibration curve linearity (All r were larger than 0.9996), sensitivity (lowest limit of quantification was 0.12 μg/mL), method accuracy (within 6.6% in terms of relative error), and precision (relative standard deviations of intra- and interday precision were less than 7.8%). These results demonstrated that the simple, reliable, and automatic method based on on-line column extraction and binary peak focusing is a promising approach for therapeutic drug monitoring in complex biomatrix samples.

  19. Sequential flow injection analysis system on-line coupled to high intensity focused ultrasound: green methodology for trace analysis applications as demonstrated for the determination of inorganic and total mercury in waters and urine by cold vapor atomic absorption spectrometry.

    Science.gov (United States)

    Fernandez, C; Conceição, Antonio C L; Rial-Otero, R; Vaz, C; Capelo, J L

    2006-04-15

    A new concept is presented for green analytical applications based on coupling on-line high-intensity focused ultrasound (HIFU) with a sequential injection/flow injection analysis (SIA/FIA) system. The potential of the SIA/HIFU/FIA scheme is demonstrated by taking mercury as a model analyte. Using inorganic mercury, methylmercury, phenylmercury, and diphenylmercury, the usefulness of the proposed methodology for the determination of inorganic and total mercury in waters and urine was demonstrated. The procedure requires low sample volumes and reagents and can be further applied to all chemical reactions involving HIFU. The inherent advantages of SIA, FIA, and HIFU applications in terms of high throughput, automation, low reagent consumption, and green chemistry are accomplished together for the first time in the present work.

  20. A Single-Wing Removal Method to Assess Correspondence Between Gene Expression and Phenotype in Butterflies: The Case of Distal-less.

    Science.gov (United States)

    Adhikari, Kiran; Otaki, Joji M

    2016-02-01

    It is often desirable but difficult to retrieve information on the mature phenotype of an immature tissue sample that has been subjected to gene expression analysis. This problem cannot be ignored when individual variation within a species is large. To circumvent this problem in the butterfly wing system, we developed a new surgical method for removing a single forewing from a pupa using Junonia orithya; the operated pupa was left to develop to an adult without eclosion. The removed right forewing was subjected to gene expression analysis, whereas the non-removed left forewing was examined for color patterns. As a test case, we focused on Distal-less (Dll), which likely plays an active role in inducing elemental patterns, including eyespots. The Dll expression level in forewings was paired with eyespot size data from the same individual. One third of the operated pupae survived and developed wing color patterns. Dll expression levels were significantly higher in males than in females, although male eyespots were smaller in size than female eyespots. Eyespot size data showed weak but significant correlations with the Dll expression level in females. These results demonstrate that a single-wing removal method was successfully applied to the butterfly wing system and suggest the weak and non-exclusive contribution of Dll to eyespot size determination in this butterfly. Our novel methodology for establishing correspondence between gene expression and phenotype can be applied to other candidate genes for color pattern development in butterflies. Conceptually similar methods may also be applicable in other developmental systems.

  1. Determination of bisphenol-type endocrine disrupting compounds in food-contact recycled-paper materials by focused ultrasonic solid-liquid extraction and ultra performance liquid chromatography-high resolution mass spectrometry.

    Science.gov (United States)

    Pérez-Palacios, David; Fernández-Recio, Miguel Ángel; Moreta, Cristina; Tena, María Teresa

    2012-09-15

    Focused ultrasonic solid-liquid extraction (FUSLE) and reverse-phase ultra performance liquid chromatography (UPLC) coupled to a quadrupole-time of flight mass spectrometer (Q-TOF-MS) was applied to the determination of bisphenol-type endocrine disrupting compounds (EDCs) in food-contact recycled-paper materials. Recycled paper is a potential source of EDCs. Bisphenol A (BPA), bisphenol F (BPF) and their derivatives bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) are used for the production of epoxy resins employed in the formulation of printing inks. The FUSLE of bisphenol-type EDCs from packaging is reported for the first time. First, different extraction solvents were studied and methanol was selected. Then, the main FUSLE factors affecting the extraction efficiency (solvent volume, extraction time and ultrasonic irradiation power) were studied by means of a central composite design. The FUSLE conditions selected for further experiments were 20 ml of methanol at ultrasonic amplitude of 100% for 5s. Finally, the number of extraction cycles necessary for complete extraction was established in two. The analysis of the FUSLE extracts was carried out by UPLC-Q-TOF-MS with electrospray ionization and the determination of the four analytes took place in only 4 min. The FUSLE and UPLC-ESI-QTOF-MS method was validated and applied to the analysis of different food-contact recycled-paper-based materials and packaging. The proposed method provided recoveries from 72% to 97%, repeatability and intermediate precision under 9% and 14%, respectively, and detection limits of 0.33, 0.16, 0.65 and 0.40 μg/g for BPA, BPF, BADGE and BFDGE, respectively. The analysis of paper and cardboard samples confirmed the presence of EDCs in these packaging.

  2. Scaled signal intensity of uterine fibroids based on T2-weighted MR images: a potential objective method to determine the suitability for magnetic resonance-guided focused ultrasound surgery of uterine fibroids

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun [CHA University, Comprehensive Gynecologic Cancer Center, CHA Bundang Medical Center, Gyunggi-do (Korea, Republic of); Yoon, Sang-Wook [CHA University, Department of Diagnostic Radiology, CHA Bundang Medical Center, Sungnam-si, Gyunggi-do (Korea, Republic of); Sokolov, Amit [InSightec Ltd., Haifa (Israel)

    2015-12-15

    Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a non-invasive method to treat uterine fibroids. To help determine the patient suitability for MRgFUS, we propose a new objective measure: the scaled signal intensity (SSI) of uterine fibroids in T2 weighted MR images (T2WI). Forty three uterine fibroids in 40 premenopausal women were included in this retrospective study. SSI of each fibroid was measured from the screening T2WI by standardizing its mean signal intensity to a 0-100 scale, using reference intensities of rectus abdominis muscle (0) and subcutaneous fat (100). Correlation between the SSI and the non-perfused volume (NPV) ratio (a measure for treatment success) was calculated. Pre-treatment SSI showed a significant inverse-correlation with post treatment NPV ratio (p < 0.05). When dichotomizing NPV ratio at 45 %, the optimal cut off value of the SSI was found to be 16.0. A fibroid with SSI value 16.0 or less can be expected to have optimal responses. The SSI of uterine fibroids in T2WI can be suggested as an objective parameter to help in patient selection for MRgFUS. (orig.)

  3. The feasibility of determining the effectiveness and cost-effectiveness of medication organisation devices compared with usual care for older people in a community setting: systematic review, stakeholder focus groups and feasibility randomised controlled trial.

    Science.gov (United States)

    Bhattacharya, Debi; Aldus, Clare F; Barton, Garry; Bond, Christine M; Boonyaprapa, Sathon; Charles, Ian S; Fleetcroft, Robert; Holland, Richard; Jerosch-Herold, Christina; Salter, Charlotte; Shepstone, Lee; Walton, Christine; Watson, Steve; Wright, David J

    2016-07-01

    Medication organisation devices (MODs) provide compartments for a patient's medication to be organised into the days of the week and the recommended times the medication should be taken. To define the optimal trial design for testing the clinical effectiveness and cost-effectiveness of MODs. The feasibility study comprised a systematic review and focus groups to inform a randomised controlled trial (RCT) design. The resulting features were tested on a small scale, using a 2 × 2 factorial design to compare MODs with usual packaging and to compare weekly with monthly supply. The study design was then evaluated. Potential participants were identified by medical practices. Aged over 75 years, prescribed at least three solid oral dosage form medications, unintentionally non-adherent and self-medicating. Participants were excluded if deemed by their health-care team to be unsuitable. One of three MODs widely used in routine clinical practice supplied either weekly or monthly. To identify the most effective method of participant recruitment, to estimate the prevalence of intentional and unintentional non-adherence in an older population, to provide a point estimate of the effect size of MODs relative to usual care and to determine the feasibility and acceptability of trial participation. The systematic review included MOD studies of any design reporting medication adherence, health and social outcomes, resource utilisation or dispensing or administration errors. Focus groups with patients, carers and health-care professionals supplemented the systematic review to inform the RCT design. The resulting design was implemented and then evaluated through questionnaires and group discussions with participants and health-care professionals involved in trial delivery. Studies on MODs are largely of poor quality. The relationship between adherence and health outcomes is unclear. Of the limited studies reporting health outcomes, some reported a positive relationship while some

  4. Focused ultrasound in ophthalmology

    Directory of Open Access Journals (Sweden)

    Silverman RH

    2016-09-01

    Full Text Available Ronald H Silverman1,2 1Department of Ophthalmology, Columbia University Medical Center, 2F.L. Lizzi Center for Biomedical Engineering, Riverside Research, New York, NY, USA Abstract: The use of focused ultrasound to obtain diagnostically significant information about the eye goes back to the 1950s. This review describes the historical and technological development of ophthalmic ultrasound and its clinical application and impact. Ultrasound, like light, can be focused, which is crucial for formation of high-resolution, diagnostically useful images. Focused, single-element, mechanically scanned transducers are most common in ophthalmology. Specially designed transducers have been used to generate focused, high-intensity ultrasound that through thermal effects has been used to treat glaucoma (via cilio-destruction, tumors, and other pathologies. Linear and annular transducer arrays offer synthetic focusing in which precise timing of the excitation of independently addressable array elements allows formation of a converging wavefront to create a focus at one or more programmable depths. Most recently, linear array-based plane-wave ultrasound, in which the array emits an unfocused wavefront and focusing is performed solely on received data, has been demonstrated for imaging ocular anatomy and blood flow. While the history of ophthalmic ultrasound extends back over half-a-century, new and powerful technologic advances continue to be made, offering the prospect of novel diagnostic capabilities. Keywords: ophthalmic ultrasound, ultrasound biomicroscopy (UBM, high-intensity focused ultrasound (HIFU, ultrafast imaging, Doppler imaging 

  5. Space Focus Lead Report

    Energy Technology Data Exchange (ETDEWEB)

    Reeves, Geoffrey D. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-08-10

    The Space Focus team is tasked with the definition of the Space Focused Science Topics, and with the review and ranking of the CSES proposals received in all the program areas. This is achieved by dedicated meetings or a series of informal discussions and/or e-mail reviews.

  6. FOCUS: Sustainable Mathematics Successes

    Science.gov (United States)

    Mireles, Selina V.; Acee, Taylor W.; Gerber, Lindsey N.

    2014-01-01

    The FOCUS (Fundamentals of Conceptual Understanding and Success) Co-Requisite Model Intervention (FOCUS Intervention) for College Algebra was developed as part of the Developmental Education Demonstration Projects (DEDP) in Texas. The program was designed to use multiple services, courses, and best practices to support student completion of a…

  7. Focusing Automatic Code Inspections

    NARCIS (Netherlands)

    Boogerd, C.J.

    2010-01-01

    Automatic Code Inspection tools help developers in early detection of defects in software. A well-known drawback of many automatic inspection approaches is that they yield too many warnings and require a clearer focus. In this thesis, we provide such focus by proposing two methods to prioritize

  8. Planar-Focusing Cathodes

    CERN Document Server

    Lewellen, J W

    2005-01-01

    Conventional pi-mode rf photoinjectors typically use magnetic solenoids for emittance compensation. This provides independent focusing strength, but can complicate rf power feed placement, introduce asymmetries (due to coil crossovers), and greatly increase the cost of the photoinjector. Cathode-region focusing can also provide for a form of emittance compensation. Typically this method strongly couples focusing strength to the field gradient on the cathode, however, and also requires altering the longitudinal position of the cathode to change the focusing. We propose a new method for achieving cathode-region variable-strength focusing for emittance compensation. The new method reduces the coupling to the gradient on the cathode, and does not require a change in the longitudinal position of the cathode. Expected performance for an S-band system is similar to conventional solenoid-based designs. This paper presents the results of rf cavity and beam dynamics simulations of the new design.

  9. Simultaneous determination of acrylamide, asparagine and glucose in food using short chain methyl imidazolium ionic liquid based ultrasonic assisted extraction coupled with analyte focusing by ionic liquid micelle collapse capillary electrophoresis.

    Science.gov (United States)

    Abd El-Hady, Deia; Albishri, Hassan M

    2015-12-01

    Acrylamide (AA) is a known lethal neurotoxin and carcinogen. AA is formed in foods during the browning process by the Maillard reaction of glucose (GL) with asparagine (AS). For the first time, the simultaneous online preconcentration and separation of AA, AS and GL using analyte focusing by ionic liquid micelle collapse capillary electrophoresis (AFILMC) was presented. Samples were prepared in a 1-butyl-3-methylimidazolium bromide (BMIMBr) micellar matrix with a conductivity 4 times greater than that of the running buffer (12.5 mmol L(-1) phosphate buffer at pH 8.5). Samples were hydrodynamically injected into a fused silica capillary at 25.0 mbar for 25.0 s. Separations were performed by applying a voltage of 25.0 kV and a detection at 200.0 nm. To sufficiently reduce BMIMBr adsorption on the interior surface of capillary, an appropriate rinsing procedure by hydrochloric acid and water was optimized. AFILMC measurements of analytes within the concentration range of 0.05-10.0 μmol L(-1) achieved adequate reproducibility and accuracy with RSD 1.14-3.42% (n=15) and recovery 98.0-110.0%, respectively. Limits of detections were 0.71 ng g(-1) AA, 1.06 ng g(-1) AS and 27.02 ng g(-1) GL with linearity ranged between 2.2 and 1800 ng g(-1). The coupling of AFILMC with IL based ultrasonic assisted extraction (ILUAE) was successfully applied to the efficient extraction and determination of AA, AS and GL in bread samples. The structure of ILs has significant effects on the extraction efficiency of analytes. The optimal extraction efficiency (97.8%) was achieved by an aqueous extraction with 4:14 ratio of sample: 3.0 mol L(-1) BMIMBr followed by sonication at 35 °C. The proposed combination of ILUAE and AFILMC was simple, ecofriendly, reliable and inexpensive to analyze a toxic compound and its precursors in bread which is applicable to food safety.

  10. New focused crawling algorithm

    Institute of Scientific and Technical Information of China (English)

    Su Guiyang; Li Jianhua; Ma Yinghua; Li Shenghong; Song Juping

    2005-01-01

    Focused carawling is a new research approach of search engine. It restricts information retrieval and provides search service in specific topic area. Focused crawling search algorithm is a key technique of focused crawler which directly affects the search quality. This paper first introduces several traditional topic-specific crawling algorithms, then an inverse link based topic-specific crawling algorithm is put forward. Comparison experiment proves that this algorithm has a good performance in recall, obviously better than traditional Breadth-First and Shark-Search algorithms. The experiment also proves that this algorithm has a good precision.

  11. Final focus test beam

    Energy Technology Data Exchange (ETDEWEB)

    1991-03-01

    This report discusses the following: the Final Focus Test Beam Project; optical design; magnets; instrumentation; magnetic measurement and BPM calibration; mechanical alignment and stabilization; vacuum system; power supplies; control system; radiation shielding and personnel protection; infrastructure; and administration.

  12. Focus group discussions

    CERN Document Server

    Hennink, Monique M

    2014-01-01

    The Understanding Research series focuses on the process of writing up social research. The series is broken down into three categories: Understanding Statistics, Understanding Measurement, and Understanding Qualitative Research. The books provide researchers with guides to understanding, writing, and evaluating social research. Each volume demonstrates how research should be represented, including how to write up the methodology as well as the research findings. Each volume also reviews how to appropriately evaluate published research. Focus Group Discussions addresses the challenges associated with conducting and writing focus group research. It provides detailed guidance on the practical and theoretical considerations in conducting focus group discussions including: designing the discussion guide, recruiting participants, training a field team, moderating techniques and ethical considerations. Monique Hennink describes how a methodology section is read and evaluated by others, such as journal reviewers or ...

  13. CLIC Final Focus Studies

    CERN Document Server

    Tomás, R; Schulte, Daniel; Zimmermann, Frank

    2006-01-01

    The CLIC final focus system has been designed based on the local compensation scheme proposed by P. Raimondi and A. Seryi. However, there exist important chromatic aberrations that deteriorate the performance of the system. This paper studies the optimization of the final focus based on the computation of the higher orders of the map using MAD-X and PTC. The use of octupole tail folding to reduce the size of the halo in the locations with aperture limitations is also discussed.

  14. Electron beam focusing system

    Energy Technology Data Exchange (ETDEWEB)

    Dikansky, N.; Nagaitsev, S.; Parkhomchuk, V.

    1997-09-01

    The high energy electron cooling requires a very cold electron beam. Thus, the electron beam focusing system is very important for the performance of electron cooling. A system with and without longitudinal magnetic field is presented for discussion. Interaction of electron beam with the vacuum chamber as well as with the background ions and stored antiprotons can cause the coherent electron beam instabilities. Focusing system requirements needed to suppress these instabilities are presented.

  15. High harmonics focusing undulator

    Energy Technology Data Exchange (ETDEWEB)

    Varfolomeev, A.A.; Hairetdinov, A.H.; Smirnov, A.V.; Khlebnikov, A.S. [Kurchatov Institute, Moscow (Russian Federation)

    1995-12-31

    It was shown in our previous work that there exist a possibility to enhance significantly the {open_quote}natural{close_quote} focusing properties of the hybrid undulator. Here we analyze the actual undulator configurations which could provide such field structure. Numerical simulations using 2D code PANDIRA were carried out and the enhanced focusing properties of the undulator were demonstrated. The obtained results provide the solution for the beam transport in a very long (short wavelength) undulator schemes.

  16. Plutonium focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this new approach, EM developed a management structure and principles that led to the creation of specific Focus Areas. These organizations were designed to focus the scientific and technical talent throughout DOE and the national scientific community on the major environmental restoration and waste management problems facing DOE. The Focus Area approach provides the framework for intersite cooperation and leveraging of resources on common problems. After the original establishment of five major Focus Areas within the Office of Technology Development (EM-50, now called the Office of Science and Technology), the Nuclear Materials Stabilization Task Group (EM-66) followed the structure already in place in EM-50 and chartered the Plutonium Focus Area (PFA). The following information outlines the scope and mission of the EM, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  17. EDITORIAL: Focus on Plasmonics FOCUS ON PLASMONICS

    Science.gov (United States)

    Bozhevolnyi, Sergey; García-Vidal, Francisco

    2008-10-01

    Plasmonics is an emerging field in optics dealing with the so-called surface plasmons whose extraordinary properties are being both analyzed from a fundamental point of view and exploited for numerous technological applications. Surface plasmons associated with surface electron density oscillations decorating metal-dielectric interfaces were discovered by Rufus Ritchie in the 1950s. Since the seventies, the subwavelength confinement of electromagnetic fields as well as their enhancement inherent to the surface plasmon excitation has been widely used for spectroscopic purposes. Recent advances in nano-fabrication, characterization and modelling techniques have allowed unique properties of these surface electromagnetic modes to be explored with respect to subwavelength field localization and waveguiding, opening the path to truly nanoscale plasmonic optical devices. This area of investigation also has interesting links with research on photonic band gap materials and the field of optical metamaterials. Nowadays, plasmonics can be seen as a mature interdisciplinary area of research in which scientists coming from different backgrounds (chemistry, physics, optics and engineering) strive to discover and exploit new and exciting phenomena associated with surface plasmons. The already made and forthcoming discoveries will have impacts in many fields of science and technology, including not only photonics and materials science but also computation, biology and medicine, among others. This focus issue of New Journal of Physics is intended to cover all the aforementioned capabilities of surface plasmons by presenting a current overview of state-of-the-art advances achieved by the leading groups in this field of research. The below list of articles represents the first contributions to the collection and further additions will appear soon. Focus on Plasmonics Contents Nanoantenna array-induced fluorescence enhancement and reduced lifetimes Reuben M Bakker, Vladimir P Drachev

  18. Decontamination & decommissioning focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    In January 1994, the US Department of Energy Office of Environmental Management (DOE EM) formally introduced its new approach to managing DOE`s environmental research and technology development activities. The goal of the new approach is to conduct research and development in critical areas of interest to DOE, utilizing the best talent in the Department and in the national science community. To facilitate this solutions-oriented approach, the Office of Science and Technology (EM-50, formerly the Office of Technology Development) formed five Focus AReas to stimulate the required basic research, development, and demonstration efforts to seek new, innovative cleanup methods. In February 1995, EM-50 selected the DOE Morgantown Energy Technology Center (METC) to lead implementation of one of these Focus Areas: the Decontamination and Decommissioning (D & D) Focus Area.

  19. Focusing Vacuum Fluctuations, 2

    CERN Document Server

    Ford, L H

    2002-01-01

    The quantization of the scalar and electromagnetic fields in the presence of a parabolic mirror is further developed in the context of a geometric optics approximation. We calculate the mean squared scalar and electric fields near the focal line of a parabolic cylindrical mirror. These quantities are found to grow as inverse powers of the distance from the focus. We give a combination of analytic and numerical results for the mean squared fields. In particular, we find that the mean squared electric field can be either negative or positive, depending upon the choice of parameters. The case of a negative mean squared electric field corresponds to a repulsive Van der Waals force on an atom near the focus, and to a region of negative energy density. Similarly, a positive value corresponds to an attractive force and a possibility of atom trapping in the vicinity of the focus.

  20. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...... effectively measures the intended phenomenon (i.e., journal specialisation). Only weak correlations were found between journal re-citations and obsolescence, journal self-citations, and number of references. Conclusions. The focus factor successfully measures journal specialisation over time. Measures based...

  1. [Focused musculoskeletal sonography].

    Science.gov (United States)

    Horn, Rudolf

    2015-09-16

    Even in emergent situations, focused musculoskeletal sonography must not be overlooked. It has a place in traumatology no less valuable than its place in internal medicine. It can be used to identify traumatic joint effusions, occult fractures and fissures, joint inflammation, muscle and tendon rupture; it can differentiate soft tissue swelling, locate a foreign body, or identify the location of fractures. Focused ultrasound should be performed by the attending physician directly at the patient’s bedside, in order to answer these specific questions.

  2. A Focused Bayesian Information Criterion

    Directory of Open Access Journals (Sweden)

    Georges Nguefack-Tsague

    2014-01-01

    Full Text Available Myriads of model selection criteria (Bayesian and frequentist have been proposed in the literature aiming at selecting a single model regardless of its intended use. An honorable exception in the frequentist perspective is the “focused information criterion” (FIC aiming at selecting a model based on the parameter of interest (focus. This paper takes the same view in the Bayesian context; that is, a model may be good for one estimand but bad for another. The proposed method exploits the Bayesian model averaging (BMA machinery to obtain a new criterion, the focused Bayesian model averaging (FoBMA, for which the best model is the one whose estimate is closest to the BMA estimate. In particular, for two models, this criterion reduces to the classical Bayesian model selection scheme of choosing the model with the highest posterior probability. The new method is applied in linear regression, logistic regression, and survival analysis. This criterion is specially important in epidemiological studies in which the objective is often to determine a risk factor (focus for a disease, adjusting for potential confounding factors.

  3. A Material Focus

    DEFF Research Database (Denmark)

    Vallgårda, Anna K. A.; Sokoler, Tomas

    2009-01-01

    In this paper we build on the notion of computational composites, which hold a material perspective on computational technology. We argue that a focus on the material aspects of the technology could be a fruitful approach to achieve new expressions and to gain a new view on the technology's role...

  4. Curriculum Mapping. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2008-01-01

    This "Focus On" discusses curriculum mapping, a process that allows educators to align the curriculum both within and across grades and to ensure that the curriculum is in line with school, local, and state standards. It outlines the steps of the curriculum mapping process from planning the mapping initiative to creating and editing curriculum…

  5. Youth Leadership. IDRA Focus.

    Science.gov (United States)

    IDRA Newsletter, 1995

    1995-01-01

    This theme issue focuses on motivating young people to learn by providing leadership opportunities in school. "Coca-Cola Valued Youth Program: Assessing Progress" (Josie Danini Supik) examines the program's success. This program, which trains high-risk middle and high school students as tutors of younger children, has dramatically…

  6. Adolescent Literacy. Focus On

    Science.gov (United States)

    Molineaux, Rebecca

    2009-01-01

    Evidence suggests that there is a crisis in adolescent literacy. Part of the problem is that students often receive little literacy instruction after elementary school. This "Focus On" examines the literacy instruction that adolescents need to be successful as they move on to more challenging texts in middle and high school. In addition, this…

  7. Neocortical focus: experimental view.

    Science.gov (United States)

    Timofeev, Igor; Chauvette, Sylvain; Soltani, Sara

    2014-01-01

    All brain normal or pathological activities occur in one of the states of vigilance: wake, slow-wave sleep, or REM sleep. Neocortical seizures preferentially occur during slow-wave sleep. We provide a description of neuronal behavior and mechanisms mediating such a behavior within neocortex taking place in natural states of vigilance as well as during seizures pointing to similarities and differences exhibited during sleep and seizures. A concept of epileptic focus is described using a model of cortical undercut, because in that model, the borders of the focus are well defined. In this model, as in other models of acquired epilepsy, the main factor altering excitability is deafferentation, which upregulates neuronal excitability that promotes generation of seizures. Periods of disfacilitation recorded during slow-wave sleep further upregulate neuronal excitability. It appears that the state of neurons and neuronal network in the epileptic focus produced by deafferentation are such that seizures cannot be generated there. Instead, seizures always start around the perimeter of the undercut cortex. Therefore, we define these areas as the seizure focus. In this zone, neuronal connectivity and excitability are moderately enhanced, lowering the threshold for seizure generation. © 2014 Elsevier Inc. All rights reserved.

  8. Focusing of electromagnetic waves

    Energy Technology Data Exchange (ETDEWEB)

    Dhayalan, V.

    1996-12-31

    The focusing of electromagnetic waves inside a slab has been examined together with two special cases in which the slab is reduced to a single interface or a single medium. To that end the exact solutions for the fields inside a layered medium have been used, given in terms of the outside current source in order to obtain the solutions for the focused electric field inside a slab. Both exact and asymptotic solutions of the problem have been considered, and the validity of the latter has been discussed. The author has developed a numerical algorithm for evaluation of the diffraction integral with special emphasis on reducing the computing time. The numerical techniques in the paper can be readily applied to evaluate similar diffraction integrals occurring e.g. in microstrip antennas. 46 refs.

  9. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    is demonstrated on a selection of general science journals and on a selection of medical journals. The reference lists of each journal are compared year by year, and the percentage of re-citations is calculated by dividing the number of re-citations with the total number of citations each year. Analysis......Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...

  10. Focus on Succes

    OpenAIRE

    Ivan Slimák; Kristina Zgodavova

    2011-01-01

    The Editor wishes to present the need and form of turning the focus of individuals and organisations to success, based on evaluating understanding of the situation, on complex improving the quality of work, production and life, and on awareness of accountability for consequences of one’s actions in the given environment and time. Understood by success is sustained financial and non-financial prosperity, whilst decisive is the evaluating process, the key element is loyalty of natural and physi...

  11. Dense Plasma Focus Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Li, Hui [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Li, Shengtai [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jungman, Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hayes-Sterbenz, Anna Catherine [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-08-31

    The mechanisms for pinch formation in Dense Plasma Focus (DPF) devices, with the generation of high-energy ions beams and subsequent neutron production over a relatively short distance, are not fully understood. Here we report on high-fidelity 2D and 3D numerical magnetohydrodynamic (MHD) simulations using the LA-COMPASS code to study the pinch formation dynamics and its associated instabilities and neutron production.

  12. Particle Accelerator Focus Automation

    Directory of Open Access Journals (Sweden)

    Lopes José

    2017-08-01

    Full Text Available The Laboratório de Aceleradores e Tecnologias de Radiação (LATR at the Campus Tecnológico e Nuclear, of Instituto Superior Técnico (IST has a horizontal electrostatic particle accelerator based on the Van de Graaff machine which is used for research in the area of material characterization. This machine produces alfa (He+ and proton (H+ beams of some μA currents up to 2 MeV/q energies. Beam focusing is obtained using a cylindrical lens of the Einzel type, assembled near the high voltage terminal. This paper describes the developed system that automatically focuses the ion beam, using a personal computer running the LabVIEW software, a multifunction input/output board and signal conditioning circuits. The focusing procedure consists of a scanning method to find the lens bias voltage which maximizes the beam current measured on a beam stopper target, which is used as feedback for the scanning cycle. This system, as part of a wider start up and shut down automation system built for this particle accelerator, brings great advantages to the operation of the accelerator by turning it faster and easier to operate, requiring less human presence, and adding the possibility of total remote control in safe conditions.

  13. Particle Accelerator Focus Automation

    Science.gov (United States)

    Lopes, José; Rocha, Jorge; Redondo, Luís; Cruz, João

    2017-08-01

    The Laboratório de Aceleradores e Tecnologias de Radiação (LATR) at the Campus Tecnológico e Nuclear, of Instituto Superior Técnico (IST) has a horizontal electrostatic particle accelerator based on the Van de Graaff machine which is used for research in the area of material characterization. This machine produces alfa (He+) and proton (H+) beams of some μA currents up to 2 MeV/q energies. Beam focusing is obtained using a cylindrical lens of the Einzel type, assembled near the high voltage terminal. This paper describes the developed system that automatically focuses the ion beam, using a personal computer running the LabVIEW software, a multifunction input/output board and signal conditioning circuits. The focusing procedure consists of a scanning method to find the lens bias voltage which maximizes the beam current measured on a beam stopper target, which is used as feedback for the scanning cycle. This system, as part of a wider start up and shut down automation system built for this particle accelerator, brings great advantages to the operation of the accelerator by turning it faster and easier to operate, requiring less human presence, and adding the possibility of total remote control in safe conditions.

  14. Subsurface contaminants focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The US Department of Enregy (DOE) Subsurface Contaminants Focus Area is developing technologies to address environmental problems associated with hazardous and radioactive contaminants in soil and groundwater that exist throughout the DOE complex, including radionuclides, heavy metals; and dense non-aqueous phase liquids (DNAPLs). More than 5,700 known DOE groundwater plumes have contaminated over 600 billion gallons of water and 200 million cubic meters of soil. Migration of these plumes threatens local and regional water sources, and in some cases has already adversely impacted off-site rsources. In addition, the Subsurface Contaminants Focus Area is responsible for supplying technologies for the remediation of numerous landfills at DOE facilities. These landfills are estimated to contain over 3 million cubic meters of radioactive and hazardous buried Technology developed within this specialty area will provide efective methods to contain contaminant plumes and new or alternative technologies for development of in situ technologies to minimize waste disposal costs and potential worker exposure by treating plumes in place. While addressing contaminant plumes emanating from DOE landfills, the Subsurface Contaminants Focus Area is also working to develop new or alternative technologies for the in situ stabilization, and nonintrusive characterization of these disposal sites.

  15. Rheological phenomena in focus

    CERN Document Server

    Boger, DV

    1993-01-01

    More than possibly any other scientific discipline, rheology is easily visualized and the relevant literature contains many excellent photographs of unusual and often bizarre phenomena. The present book brings together these photographs for the first time. They are supported by a full explanatory text. Rheological Phenomena in Focus will be an indispensable support manual to all those who teach rheology or have to convince colleagues of the practical relevance of the subject within an industrial setting. For those who teach fluid mechanics, the book clearly illustrates the difference be

  16. Antiproton Focus Horn

    CERN Multimedia

    1974-01-01

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet.For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  17. The Individually Focused Interview

    DEFF Research Database (Denmark)

    Clausen, Aksel Skovgaard

    2012-01-01

    In this paper, I argue—with an example—that under certain conditions replacement of audio transcriptions with a combination of simultaneously taken and jointly produced notes can be done without affecting reliability, validity, and transparency. These conditions are: (1) professional or otherwise...... relatively “strong” interviewees (interview persons: IPs) with diverse backgrounds; (2) thorough planning of the interview with well-focused themes; and (3) a thorough and repeated introduction to the interview. The omission of audio transcriptions is an obvious solution to the researcher who wants a breadth...

  18. Focus on Organic Conductors

    Directory of Open Access Journals (Sweden)

    Shinya Uji, Takehiko Mori and Toshihiro Takahashi

    2009-01-01

    Full Text Available Organic materials are usually thought of as electrical insulators. Progress in chemical synthesis, however, has brought us a rich variety of conducting organic materials, which can be classified into conducting polymers and molecular crystals. Researchers can realize highly conducting molecular crystals in charge-transfer complexes, where suitable combinations of organic electron donor or acceptor molecules with counter ions or other organic molecules provide charge carriers. By means of a kind of chemical doping, the charge-transfer complexes exhibit high electrical conductivity and, thanks to their highly crystalline nature, even superconductivity has been observed. This focus issue of Science and Technology of Advanced Materials is devoted to the research into such 'organic conductors'The first organic metal was (TTF(TCNQ, which was found in 1973 to have high conductivity at room temperature and a metal–insulator transition at low temperatures. The first organic superconductor was (TMTSF2PF6, whose superconductivity under high pressures was reported by J´erome in 1980. After these findings, the research on organic conductors exploded. Hundreds of organic conductors have been reported, among which more than one hundred exhibit superconductivity. Recently, a single-component organic conductor has been found with metallic conductivity down to low temperatures.In these organic conductors, in spite of their simple electronic structures, much new physics has arisen from the low dimensionality. Examples are charge and spin density waves, characteristic metal–insulator transitions, charge order, unconventional superconductivity, superconductor–insulator transitions, and zero-gap conductors with Dirac cones. The discovery of this new physics is undoubtedly derived from the development of many intriguing novel organic conductors. High quality single crystals are indispensable to the precise measurement of electronic states.This focus issue

  19. CERN In Focus

    CERN Multimedia

    CERN audiovisual service

    2008-01-01

    First edition 2008 of Cern in Focus. On behalf of the audiovisual team, a selection of the latest videos filmed at CERN. Every six weeks, we will bring you the latest in CERN's activities, from LHC start up to the Computing Grid, featuring the experiments and many other goings-on at CERN. The agenda of this first edition of CERN in Focus features the visit of the prime minister of Malta, Lawrence Gonzi... CMS and the final descent of the YE-1 end cap... The departure of UA1 magnets to Japan... The start up of sectors 4 and 5... And finally, in our sports round up... We'll talk about football. New in brief this month... The final bolt is in place : On 7th November, in the bowels of the LHC tunnel, CERN's Director General Robert Aymar tightened a gold-plated bolt for the last arc interconnection of sector 1-2. This symbolic gesture marks the completion of all the arc interconnections of the LHC. Last welding work: it was never going to be an easy task. On this day last year just one sector had been completed,...

  20. Butterfly Wings Are Three-Dimensional: Pupal Cuticle Focal Spots and Their Associated Structures in Junonia Butterflies.

    Science.gov (United States)

    Taira, Wataru; Otaki, Joji M

    2016-01-01

    Butterfly wing color patterns often contain eyespots, which are developmentally determined at the late larval and early pupal stages by organizing activities of focal cells that can later form eyespot foci. In the pupal stage, the focal position of a future eyespot is often marked by a focal spot, one of the pupal cuticle spots, on the pupal surface. Here, we examined the possible relationships of the pupal focal spots with the underneath pupal wing tissues and with the adult wing eyespots using Junonia butterflies. Large pupal focal spots were found in two species with large adult eyespots, J. orithya and J. almana, whereas only small pupal focal spots were found in a species with small adult eyespots, J. hedonia. The size of five pupal focal spots on a single wing was correlated with the size of the corresponding adult eyespots in J. orithya. A pupal focal spot was a three-dimensional bulge of cuticle surface, and the underside of the major pupal focal spot exhibited a hollowed cuticle in a pupal case. Cross sections of a pupal wing revealed that the cuticle layer shows a curvature at a focal spot, and a positional correlation was observed between the cuticle layer thickness and its corresponding cell layer thickness. Adult major eyespots of J. orithya and J. almana exhibited surface elevations and depressions that approximately correspond to the coloration within an eyespot. Our results suggest that a pupal focal spot is produced by the organizing activity of focal cells underneath the focal spot. Probably because the focal cell layer immediately underneath a focal spot is thicker than that of its surrounding areas, eyespots of adult butterfly wings are three-dimensionally constructed. The color-height relationship in adult eyespots might have an implication in the developmental signaling for determining the eyespot color patterns.

  1. Butterfly Wings Are Three-Dimensional: Pupal Cuticle Focal Spots and Their Associated Structures in Junonia Butterflies.

    Directory of Open Access Journals (Sweden)

    Wataru Taira

    Full Text Available Butterfly wing color patterns often contain eyespots, which are developmentally determined at the late larval and early pupal stages by organizing activities of focal cells that can later form eyespot foci. In the pupal stage, the focal position of a future eyespot is often marked by a focal spot, one of the pupal cuticle spots, on the pupal surface. Here, we examined the possible relationships of the pupal focal spots with the underneath pupal wing tissues and with the adult wing eyespots using Junonia butterflies. Large pupal focal spots were found in two species with large adult eyespots, J. orithya and J. almana, whereas only small pupal focal spots were found in a species with small adult eyespots, J. hedonia. The size of five pupal focal spots on a single wing was correlated with the size of the corresponding adult eyespots in J. orithya. A pupal focal spot was a three-dimensional bulge of cuticle surface, and the underside of the major pupal focal spot exhibited a hollowed cuticle in a pupal case. Cross sections of a pupal wing revealed that the cuticle layer shows a curvature at a focal spot, and a positional correlation was observed between the cuticle layer thickness and its corresponding cell layer thickness. Adult major eyespots of J. orithya and J. almana exhibited surface elevations and depressions that approximately correspond to the coloration within an eyespot. Our results suggest that a pupal focal spot is produced by the organizing activity of focal cells underneath the focal spot. Probably because the focal cell layer immediately underneath a focal spot is thicker than that of its surrounding areas, eyespots of adult butterfly wings are three-dimensionally constructed. The color-height relationship in adult eyespots might have an implication in the developmental signaling for determining the eyespot color patterns.

  2. CERN in Focus

    CERN Multimedia

    CERN audiovisual service

    2008-01-01

    CERN in Focus 1ère édition. Le Service Audiovisuel vous propose un panorama des dernières vidéos tournées au CERN. En effet, toutes les six semaines, nous vous présenterons l'ensemble des activités, du démarrage du LHC à la grille de calcul, en passant par les différentes expériences. Au sommaire de cette édition, la visite du premier ministre de Malte, CMS et la derniere descente du YE-1 Le depart des aimants UA1 pour le Japon La mise en marche des secteurs 4 et 5 Et enfin, ATLAS et la descente... BREVES Dernieres soudures LHC Derniers boulonnages LHC College leman Appel a candidature Open Day

  3. Alliance-focused training.

    Science.gov (United States)

    Eubanks-Carter, Catherine; Muran, J Christopher; Safran, Jeremy D

    2015-06-01

    Alliance-focused training (AFT) aims to increase therapists' ability to recognize, tolerate, and negotiate alliance ruptures by increasing the therapeutic skills of self-awareness, affect regulation, and interpersonal sensitivity. In AFT, therapists are encouraged to draw on these skills when metacommunicating about ruptures with patients. In this article, we present the 3 main supervisory tasks of AFT: videotape analysis of rupture moments, awareness-oriented role-plays, and mindfulness training. We describe the theoretical and empirical support for each supervisory task, provide examples based on actual supervision sessions, and present feedback about the usefulness of the techniques from trainees in our program. We also note some of the challenges involved in conducting AFT and the importance of maintaining a strong supervisory alliance when using this training approach.

  4. The FOCUS trial

    DEFF Research Database (Denmark)

    Glenthøj, Louise B; Fagerlund, Birgitte; Randers, Lasse

    2015-01-01

    trial enrolling 126 patients meeting the standardised criteria of being at UHR for psychosis. Patients are recruited from psychiatric in- and outpatient facilities in the Copenhagen catchment area. Patients are randomised to one of the two treatment arms: cognitive remediation plus standard treatment...... functioning, psychosis-like symptoms, negative symptomatology, and depressive symptomatology as measured with the Personal and Social Performance Scale, Brief Psychiatric Rating Scale-Expanded Version, Scale for the Assessment of Negative Symptoms, and the Montgomery-Åsberg Depression Rating Scale. DISCUSSION......: This is the first trial to evaluate the effects of neurocognitive and social cognitive remediation in UHR patients. The FOCUS trial results will provide evidence on the effect of targeted and comprehensive cognitive rehabilitation on cognition, daily living, and symptomatology as well as long-term outcome...

  5. Focus on Succes

    Directory of Open Access Journals (Sweden)

    Ivan Slimák

    2011-10-01

    Full Text Available The Editor wishes to present the need and form of turning the focus of individuals and organisations to success, based on evaluating understanding of the situation, on complex improving the quality of work, production and life, and on awareness of accountability for consequences of one’s actions in the given environment and time. Understood by success is sustained financial and non-financial prosperity, whilst decisive is the evaluating process, the key element is loyalty of natural and physical persons, and the priority is loyalty of external customers. The address is targeted to would-be authors and readers of our Journal interested in engineering and management of quality of mutually correlate entities.

  6. Focusing on customer service.

    Science.gov (United States)

    1996-01-01

    This booklet is devoted to a consideration of how good customer service in family planning programs can generate demand for products and services, bring customers back, and reduce costs. Customer service is defined as increasing client satisfaction through continuous concern for client preferences, staff accountability to clients, and respect for the rights of clients. Issues discussed include the introduction of a customer service approach and gaining staff commitment. The experience of PROSALUD in Bolivia in recruiting appropriate staff, supervising staff, soliciting client feedback, and marketing services is offered as an example of a successful customer service approach. The key customer service functions are described as 1) establishing a welcoming atmosphere, 2) streamlining client flow, 3) personalizing client services, and 4) organizing and providing clear information to clients. The role of the manager in developing procedures is explored, and the COPE (Client-Oriented Provider-Efficient) process is presented as a good way to begin to make improvements. Techniques in staff training in customer service include brainstorming, role playing, using case studies (examples of which are provided), and engaging in practice sessions. Training also leads to the development of effective customer service attitudes, and the differences between these and organizational/staff-focused attitudes are illustrated in a chart. The use of communication skills (asking open-ended questions, helping clients express their concerns, engaging in active listening, and handling difficult situations) is considered. Good recovery skills are important when things go wrong. Gathering and using client feedback is the next topic considered. This involves identifying, recording, and discussing customer service issues as well as taking action on these issues and evaluating the results. The booklet ends by providing a sample of customer service indicators, considering the maintenance of a

  7. White Light Focusing Mirror

    Science.gov (United States)

    Johnson, Eric; Lyndaker, Aaron; Deyhim, Alex; Sullivan, Michael; Chance, Mark; Abel, Don; Toomey, John; Hulbert, Steven

    2007-01-01

    The NSLS X28C white-light beamline is being outfitted with a focusing mirror in order to increase, as well as control, the x-ray intensity at the sample position. The new mirror is a 50 mm × 100 mm × 1100 mm single crystal silicon cylindrical 43.1mm radius substrate bendable to a toroid from infinite to 1200 m radius. The unique feature of this mirror system is the dual use of Indalloy 51 as both a mechanism for heat transfer and a buoyant support to negate the effects of gravity. The benefit of the liquid metal support is the ability to correct for minor slope errors that take the form of a parabola. A bobber mechanism is employed to displace the fluid under the mirror +/- 1.5 mm. This allows RMS slope error correction on the order of 2 urad. The unique mounting of the mirror ensures the contributions to slope error from errant mechanical stresses due to machining tolerances are virtually non-existent. After correction, the surface figure error (measured minus ideal) is <= 0.5 urad rms.

  8. Calibration and field test of the Polar Organic Chemical Integrative Samplers for the determination of 15 endocrine disrupting compounds in wastewater and river water with special focus on performance reference compounds (PRC).

    Science.gov (United States)

    Vallejo, A; Prieto, A; Moeder, M; Usobiaga, A; Zuloaga, O; Etxebarria, N; Paschke, A

    2013-05-15

    In this work, home-made Polar Organic Chemical Integrative Samplers (POCIS) were studied for passive sampling of 15 endocrine disrupting compounds (4 alkylphenols and steroid hormones) in influent and effluent samples of wastewater treatment plants (WWTPs) as well as up- and downstream of the receiving river water. POCIS calibration at laboratory conditions was carried out using a continuous-flow calibration system. The influence of the exposure position of the POCIS within the calibration device, horizontal or vertical, to the water flow direction was evaluated. While the sampling rates of most of the target substances were not affected by the sampler position, for cis-ADT, E1, E2 and E3, the vertical position provided the highest analyte accumulation. Hence, the POCIS samplers were preferably exposed vertical to the water flow in overall experiments. Using the continuous-flow calibration device, lab-based sampling rates were determined for all the target compounds (RSBPA = 0.0326 L/d; RScisADT = 0.0800 L/d, RSE1 = 0.0398 L/d, RSEQ = 0.0516 L/d, RSTT = 0.0745 L/d, RSE2 = 0.0585 L/d, RSEE2 = 0.0406 L/d, RSNT = 0.0846 L/d, RSPG = 0.0478 L/d and RSE3 = 0.1468 L/d), except for DES, MeEE2, 4tOP, 4OP, 4NPs, where the uptake after 14 days POCIS exposure was found to be insignificant or indicated a no linear behaviour. Recoveries from POCIS extractions were in the range between 71 and 152% for most of the target analytes except for DES and E3 with around 59%. Good precision of the sampling procedure up till 20% was observed and limits of detection were at ng/L level. Two deuterated compounds ([(2)H3]-E2 and [(2)H4]-EQ) were successfully tested as performance reference compounds (PRC, [Formula: see text] = 0.0507 L/d and [Formula: see text] = 0.0543 L/d)). Finally, the POCIS samplers were tested for monitoring EDCs at two wastewater treatment plants, in Halle and Leipzig (Germany). BPA, E1, EQ, E2, MeEE2, NT, EE2, PG and E3 were quantified and their time-weighted average

  9. Stress wave focusing transducers

    Energy Technology Data Exchange (ETDEWEB)

    Visuri, S.R., LLNL

    1998-05-15

    Conversion of laser radiation to mechanical energy is the fundamental process behind many medical laser procedures, particularly those involving tissue destruction and removal. Stress waves can be generated with laser radiation in several ways: creation of a plasma and subsequent launch of a shock wave, thermoelastic expansion of the target tissue, vapor bubble collapse, and ablation recoil. Thermoelastic generation of stress waves generally requires short laser pulse durations and high energy density. Thermoelastic stress waves can be formed when the laser pulse duration is shorter than the acoustic transit time of the material: {tau}{sub c} = d/c{sub s} where d = absorption depth or spot diameter, whichever is smaller, and c{sub s} = sound speed in the material. The stress wave due to thermoelastic expansion travels at the sound speed (approximately 1500 m/s in tissue) and leaves the site of irradiation well before subsequent thermal events can be initiated. These stress waves, often evolving into shock waves, can be used to disrupt tissue. Shock waves are used in ophthalmology to perform intraocular microsurgery and photodisruptive procedures as well as in lithotripsy to fragment stones. We have explored a variety of transducers that can efficiently convert optical to mechanical energy. One such class of transducers allows a shock wave to be focused within a material such that the stress magnitude can be greatly increased compared to conventional geometries. Some transducer tips could be made to operate regardless of the absorption properties of the ambient media. The size and nature of the devices enable easy delivery, potentially minimally-invasive procedures, and precise tissue- targeting while limiting thermal loading. The transducer tips may have applications in lithotripsy, ophthalmology, drug delivery, and cardiology.

  10. Laser Beam Focus Analyser

    DEFF Research Database (Denmark)

    Nielsen, Peter Carøe; Hansen, Hans Nørgaard; Olsen, Flemming Ove

    2007-01-01

    The quantitative and qualitative description of laser beam characteristics is important for process implementation and optimisation. In particular, a need for quantitative characterisation of beam diameter was identified when using fibre lasers for micro manufacturing. Here the beam diameter limits...... the obtainable features in direct laser machining as well as heat affected zones in welding processes. This paper describes the development of a measuring unit capable of analysing beam shape and diameter of lasers to be used in manufacturing processes. The analyser is based on the principle of a rotating...... mechanical wire being swept through the laser beam at varying Z-heights. The reflected signal is analysed and the resulting beam profile determined. The development comprised the design of a flexible fixture capable of providing both rotation and Z-axis movement, control software including data capture...

  11. Approach focused on people

    Directory of Open Access Journals (Sweden)

    Roa Ruben

    2010-11-01

    Full Text Available Family and community medicine assumes a new epistemological landmark that also provides the use of instruments and tools related to it. This care model permits carrying out a visit where all categories which the health-disease process is expressed are present. Family Medicine intends to combine both visions and, for such, it gifts elements to incorporate disease as an essential part of our patient's approach systematic being the main focus the approach by problems, which is nothing but that which concerns the individual, his family or the physician, or all of them, and at times there will be nuisances while at other times, there will be diseases, and mil in other instances, all of them will co-exist. It is known that the impact of a health problem on an individual affects not only himself, but also his surroundings. In turn, the environment around this individual can act as the origin or perpetuator of the crisis, or else serve to help in solving the conflict. Distinct tools serve the purpose of knowing the context in which health crisis is developed, such as: genogram, individual and family vital cycle. Every time two people communicate, the agreement or disagreement generate possible variables. In the physician-patient relationship, this is no exception. Values, beliefs, feelings, and information of each individual different and physicians not necessarily in agreement in several issues during a visit. The objective is the need to achieve a minimum of agreements so that this visit has therapeutic effectiveness, thus being if/rpm -taw to find a common territory. Relations in general involve power; care, feelings, trust and goals. The objective in this type of relationship must be obviously shared ly both and cannot be any other than that of achieving, the highest level of health to our patient. So, our specialty, considered of low complexity, becomes a highly cognitive complexity, special and there is no doubt that it is a lot easier to handle

  12. Optimum annular focusing by a phase plate

    CERN Document Server

    Arrizón, Victor; Aguirre-Olivas, Dilia; Mellado-Villaseñor, Gabriel

    2015-01-01

    Conventional light focusing, i. e. concentration of an extended optical field within a small area around a point, is a frequently used process in Optics. An important extension to conventional focusing is the generation of the annular focal field of an optical beam. We discuss a simple optical setup that achieves this kind of focusing employing a phase plate as unique optical component. We first establish the class of beams that being transmitted through the phase plate can be focused into an annular field with topological charge of arbitrary integer order q. Then, for each beam in this class we determine the plate transmittance that generates the focal field with the maximum possible peak intensity. In particular, we discuss and implement experimentally the optimum annular focusing of a Gaussian beam. The attributes of optimum annular focal fields, namely the high peak intensity, intensity gradient and narrow annular section, are advantageous for different applications of such structured fields.

  13. Autofocus system and autofocus method for focusing on a surface

    Energy Technology Data Exchange (ETDEWEB)

    O' Neill, Mary Morabito

    2017-05-23

    An autofocus system includes an imaging device, a lens system and a focus control actuator that is configured to change a focus position of the imaging device in relation to a stage. The electronic control unit is configured to control the focus control actuator to a plurality of predetermined focus positions, and activate the imaging device to obtain an image at predetermined positions and then apply a spatial filter to the obtained images. This generates a filtered image for the obtained images. The control unit determines a focus score for the filtered images such that the focus score corresponds to a degree of focus in the obtained images. The control unit identifies a best focus position by comparing the focus score of the filtered images, and controls the focus control actuator to the best focus position corresponding to the highest focus score.

  14. Frequent external focus feedback enhances motor learning

    Directory of Open Access Journals (Sweden)

    Gabriele eWulf

    2010-11-01

    Full Text Available The present study examined the hypothesis that feedback inducing an external focus of attention enhances motor learning if it is provided frequently (i.e., 100% rather than less frequently. Children (10-12 year olds practiced a soccer throw-in task and were provided feedback about movement form. The feedback statements, provided either after every (100% or every third (33% practice trial, were similar in content but induced either an internal focus (body-movement related or external focus (movement-effect related. The results demonstrated that learning of the movement form was enhanced by external-focus feedback after every trial (100% relative to external-focus feedback after every third trial (33% or internal-focus feedback (100%, 33%, as demonstrated by immediate and delayed transfer tests without feedback. There was no difference between the two internal-focus feedback groups. These findings indicate that the attentional focus induced by feedback is an important factor in determining the effectiveness of different feedback frequencies. We argue that the informational properties of feedback cannot sufficiently account for these and related findings, and suggest that the attentional role of feedback be given greater consideration in future studies.

  15. Focusators for laser-branding

    Science.gov (United States)

    Doskolovich, L. L.; Kazanskiy, N. L.; Kharitonov, S. I.; Uspleniev, G. V.

    A new method is investigated for synthesis of computer-generated optical elements: focusators that are able to focus the radial-symmetrical laser beam into complex focal contours, in particular into alphanumeric symbols. The method is based on decomposition of the focal contour into segments of straight lines and semi-circles, following corresponding spacing out of the focusator on elementary segments (concentric rings or sectors) and solution of the inverse task of focusing from focusator segments into corresponding elements of the focal contour. The results of numerical computing of the field from synthesized focusators into the letters are presented. The theoretical efficiency of the focusators discussed is no less than 85%. The amplitude masks and the results of operational studies of synthesized focusators are presented.

  16. Focusing Electron Beams at SLAC.

    Science.gov (United States)

    Taylor, Richard L.

    1993-01-01

    Describes the development of a set of magnets that focus high-energy electron and positron beams causing them to collide, annihilate each other, and generate new particles. Explains how dipoles bend the beam, how quadrupoles focus the beam, how the focal length is calculated, and the superconducting final focus. (MDH)

  17. Conducting a Customer-Focused Performance Analysis.

    Science.gov (United States)

    Grant, David A.; Moseley, James L.

    1999-01-01

    Explains how to conduct an organization's performance analysis that focuses on customer needs by identifying the desired state, determining the current state, and identifying the current or predicted gap in performance. Considers the organization's mission, a vision or strategic plan, the organization's cultural values, and organizational goals.…

  18. "Stepping Up": A Focus on Facilitator Development

    Science.gov (United States)

    Kostouros, Patricia; Warthe, D. Gaye; Carter-Snell, Catherine; Burnett, Che

    2016-01-01

    This article examines the impact on peer facilitators in "Stepping Up," a dating violence prevention program at a Canadian university. A focus group held eight months following the delivery of the program determined the personal impact of involvement in the program. Results indicate that peer facilitators experienced personal growth as…

  19. Discussion on Form Focused Instruction

    Institute of Scientific and Technical Information of China (English)

    冯滢

    2007-01-01

    The pedagogy of language teaching has moved from one extreme-Grammar Translation Method to the other-Communicative Language Teaching.Today Form Focused Instruction(FFI)has emerged,intending to bring language forms instructionback to the communicative language classroom.Despite of the approval of this new approach,there is a hot dispute on its two types of application:Focus on Form or Focus on FormS.This article briefly analyzes FFI in recent research studies with focus on the choice between the two types of application.The tentative conclusion is FFI does show some explicit and reliable effects on accuracy and error elimination in language teaching;however,the investigation into its application is not simply either Focus on Form Or Focus on FormS,but focuses on the optimal combination of the two in teaching.

  20. Focus

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    400 Million People Shake off PovertyUN World Food Program (WFP) Executive Director James Morris recently praised the Chinese government, saying, "China has lifted several hundred million people out of poverty in less than a generation. That is an extraordinary achievement." Morris congratulated the Chinese government on its "remarkable success," adding that

  1. Focus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Ninth Congress of CPC Guangdong Provincial Committee has 880 formal delegates. This is the first timefor people representing private entrepreneurs to attend the provincial congress. In addition to eight such del-egates, there are also three representing Sino--foreign joint ventures in the province, seven from share-holding

  2. Focus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    According to a joint investigation by a group of top world companies, China has for the first time surpassed the U.S. to become the most favored destination for direct foreign investment. The Financial Times reports that the September 11th incident has provoked worries about security in the U.S among foreign investors. According to UN statistics, nearly US $50 billion of direct foreign investment was channeled into China in 2001, and still more is on its way. Foreign investment in the United States, on the other hand, dropped from its 2000 level of US $301 billion to US $125 biinon.

  3. Focus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The Chinese railway department has decided to make significant adjustments to its railway network.It is tobuild a second Beijing-Guangzhou Railway line exclusively for passenger transport.The new railway,over2.000kilometers long,will take only 10hours to cover the distance between Beijing and Guangzhou.The

  4. Focus

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    China has launched a crackdown on Internet pornography. Of China's Netizens, 70 percent are students and 20 percent are juveniles. According to conservative estimates, 46 percent of juvenile Netizens visit porn websites.

  5. Focus

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Personal Information Protection Law Under Legislative Procedure;China's Most Populous Province;New Marriage Law Brings New Trends;Beijing Repeals Regulations Governing Migrant Workers;A New Law to Regulate Electrical Junk in China;Highly-educated Jobless;Growing Up Alone;Internet Gambling Invades the Chinese Mainland;Dreams of Stardom;Chinese Smokers Consume1/3 of the World's Cigarettes.

  6. Focus

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    China's Police Force Understaffed;Newlyweds Pledge Lifelong Fidelity Before Confucius;Government Officials to Forgo "No Comment" Line;Fewer Chinese Students Study Engineering;60 Percent of Middle School Students Study-Weary;Tipping Still Not Done in China;

  7. FOCUS

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    More than 600 Posionous Trees Found in Hainan;Cyber Counseling Service for Prisoners;""Super"" Maize Bred in China;English Level Improves as Proficiency in Mother Tongue Declines;Greater Proportion oF Chinese Leaders Graduates in Liberal Arts.

  8. Focus

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Non-public Owned Enterprises Burgeon Recently the All-China Federation of Industry and Commerce published the results of its member enterprise 2001 survey. According to survey statistics, the total business income of

  9. Discussion on Form Focused Instruction

    Institute of Scientific and Technical Information of China (English)

    冯滢

    2007-01-01

    The pedagogy of language teaching has moved from one extreme-Grammar Translation Method to the other-Communicative Language Teaching.Today Form Focused Instruction(FFI) has emerged,intending to bring language forms instruction back to the communicative language classroom.Despite of the approval of this new approach,there is a hot dispute on its two types of application:Focus on Form or Focus on FormS.This article briefly analyzes FFI in recent research studies with focus on the choice between the two types ...

  10. Microflow Cytometers with Integrated Hydrodynamic Focusing

    Directory of Open Access Journals (Sweden)

    Martin Schmidt

    2013-04-01

    Full Text Available This study demonstrates the suitability of microfluidic structures for high throughput blood cell analysis. The microfluidic chips exploit fully integrated hydrodynamic focusing based on two different concepts: Two-stage cascade focusing and spin focusing (vortex principle. The sample—A suspension of micro particles or blood cells—is injected into a sheath fluid streaming at a substantially higher flow rate, which assures positioning of the particles in the center of the flow channel. Particle velocities of a few m/s are achieved as required for high throughput blood cell analysis. The stability of hydrodynamic particle positioning was evaluated by measuring the pulse heights distributions of fluorescence signals from calibration beads. Quantitative assessment based on coefficient of variation for the fluorescence intensity distributions resulted in a value of about 3% determined for the micro-device exploiting cascade hydrodynamic focusing. For the spin focusing approach similar values were achieved for sample flow rates being 1.5 times lower. Our results indicate that the performances of both variants of hydrodynamic focusing suit for blood cell differentiation and counting. The potential of the micro flow cytometer is demonstrated by detecting immunologically labeled CD3 positive and CD4 positive T-lymphocytes in blood.

  11. Regulatory focus in groupt contexts

    NARCIS (Netherlands)

    Faddegon, Krispijn Johannes

    2009-01-01

    The thesis examines the influence of group processes on the regulatory focus of individual group members. It is demonstrated that the group situation can affect group members' regulatory focus both in a top-down fashion (via the identitiy of the group) and in a bottom-up fashion (emerging from the g

  12. New Results from the FOCUS/E831 Experiment

    CERN Document Server

    Kim, D Y; Alimonti, G; Anjos, J C; Arena, V; Barberis, S; Bediaga, I; Benussi, L; Bertani, L; Bianco, S; Boca, G; Bonomi, G; Boschini, M; Butler, J N; Carrillo, S; Casimiro, E; Cawlfield, C; Cerutti, A; Cheung, H W K; Chiodini, G; Cho, K; Chung, Y S; Cinquini, L; Cuautle, E; Cumalat, J P; D'Angelo, P; Davenport, T F; De Miranda, J M; Di Corato, M; Dini, P; Dos Reis, A C; Edera, L; Engh, D; Erba, S; Fabbri, Franco Luigi; Gaines, I; Garbincius, P H; Gardner, R; Garren, L A; Giammarchi, M; Gianini, G; Gottschalk, E E; Green, S W; Göbel, C; Han, T; Hernández, H; Hosack, M; Inzani, P; Johns, W E; Kang, J S; Kasper, P H; Kim, D Y; Ko, B R; Kreymer, A E; Kryemadhi, A; Kutschke, R; Kwak, J W; Lee, K B; Leveraro, F; Liguori, G; Link, J M; Lopes-Pegna, D; Luiggi, E; López, A M; Magnin, J; Malvezzi, S; Massafferri, A; Menasce, D; Merlo, M M; Mezzadri, M; Mitchell, R; Moroni, L; Méndez, H; Nehring, M S; O'Reilly, B; Pantea, D; Paris, A; Park, H; Pedrini, D; Pepe, I M; Polycarpo, E; Pon, C; Prelz, F; Quinones, J; Rahimi, A; Ramírez, J E; Ratti, S P; Reyes, M; Riccardi, C; Rovere, M; Sala, S; Segoni, I; Sheaff, M; Sheldon, P D; Stenson, K; Sánchez-Hernández, A; Uribe, C; Vaandering, E W; Vitulo, P; Vázquez, F; Wahl, M; Wang, M; Webster, M; Wilson, J R; Wiss, J; Yager, P M; Zallo, A; Zhang, Y; Kim, Doris Yangsoo

    2003-01-01

    The E831/FOCUS experiment at Fermilab is a photoproduction experiment which generated high quality charm particles. During its run, we obtained a large data set, including more than 1 million charm mesons in the Kpi/K2pi/K3pi mode decays. The current analysis efforts by the collaboration members are quite active and diverse. I will summarize the recent papers published by the FOCUS group on topics of semileptonic decays of charm mesons.

  13. Tuning particle focusing in inertial microfluidic devices

    Science.gov (United States)

    Hood, Kaitlyn; Kahkeshani, Soroush; di Carlo, Dino; Roper, Marcus

    2014-11-01

    Particles in microfluidic devices at finite Reynolds number are subject to two forces: (i) inertial focusing and (ii) particle-particle interactions. Although microfluidic chips exploit these forces to manipulate particles for particle/cell sorting and high throughput flow cytometry, the forces are not understood well enough to allow rational design of devices that can tune and attenuate particle focusing. We present a mathematical model addressing both inertial focusing and particle interactions, and we apply our model to various channel geometries to determine the balance of forces. In addition, we present experimental data that illustrate the accuracy of our model. We will address the following questions: Why do high aspect ratio channels favor two equilibrium positions? Why do particle chains form?

  14. Plutonium focus area: Technology summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    To ensure research and development programs focus on the most pressing environmental restoration and waste management problems at the U.S. Department of Energy (DOE), the Assistant Secretary for the Office of Environmental Management (EM) established a working group in August 1993 to implement a new approach to research and technology development. As part of this approach, EM developed a management structure and principles that led to creation of specific focus areas. These organizations were designed to focus scientific and technical talent throughout DOE and the national scientific community on major environmental restoration and waste management problems facing DOE. The focus area approach provides the framework for inter-site cooperation and leveraging of resources on common problems. After the original establishment of five major focus areas within the Office of Technology Development (EM-50), the Nuclear Materials Stabilization Task Group (NMSTG, EM-66) followed EM-50`s structure and chartered the Plutonium Focus Area (PFA). NMSTG`s charter to the PFA, described in detail later in this book, plays a major role in meeting the EM-66 commitments to the Defense Nuclear Facilities Safety Board (DNFSB). The PFA is a new program for FY96 and as such, the primary focus of revision 0 of this Technology Summary is an introduction to the Focus Area; its history, development, and management structure, including summaries of selected technologies being developed. Revision 1 to the Plutonium Focus Area Technology Summary is slated to include details on all technologies being developed, and is currently planned for release in August 1996. The following report outlines the scope and mission of the Office of Environmental Management, EM-60, and EM-66 organizations as related to the PFA organizational structure.

  15. Compact electron beam focusing column

    Energy Technology Data Exchange (ETDEWEB)

    Persaud, Arun; Leung, Ka-Ngo; Reijonen, Jani

    2001-07-13

    A novel design for an electron beam focusing column has been developed at LBNL. The design is based on a low-energy spread multicusp plasma source which is used as a cathode for electron beam production. The focusing column is 10 mm in length. The electron beam is focused by means of electrostatic fields. The column is designed for a maximum voltage of 50 kV. Simulations of the electron trajectories have been performed by using the 2-D simulation code IGUN and EGUN. The electron temperature has also been incorporated into the simulations. The electron beam simulations, column design and fabrication will be discussed in this presentation.

  16. A numerical study on the oblique focus in MR-guided transcranial focused ultrasound

    Science.gov (United States)

    Hughes, Alec; Huang, Yuexi; Pulkkinen, Aki; Schwartz, Michael L.; Lozano, Andres M.; Hynynen, Kullervo

    2016-11-01

    Recent clinical data showing thermal lesions from treatments of essential tremor using MR-guided transcranial focused ultrasound shows that in many cases the focus is oblique to the main axis of the phased array. The potential for this obliquity to extend the focus into lateral regions of the brain has led to speculation as to the cause of the oblique focus, and whether it is possible to realign the focus. Numerical simulations were performed on clinical export data to analyze the causes of the oblique focus and determine methods for its correction. It was found that the focal obliquity could be replicated with the numerical simulations to within 23.2+/- {{13.6}\\circ} of the clinical cases. It was then found that a major cause of the focal obliquity was the presence of sidelobes, caused by an unequal deposition of power from the different transducer elements in the array at the focus. In addition, it was found that a 65% reduction in focal obliquity was possible using phase and amplitude corrections. Potential drawbacks include the higher levels of skull heating required when modifying the distribution of power among the transducer elements, and the difficulty at present in obtaining ideal phase corrections from CT information alone. These techniques for the reduction of focal obliquity can be applied to other applications of transcranial focused ultrasound involving lower total energy deposition, such as blood-brain barrier opening, where the issue of skull heating is minimal.

  17. Focusing of bistatic SAR data

    Science.gov (United States)

    Bia, Pietro; Ricci, Nicola; Zonno, Mariantonietta; Nico, Giovanni; Catalao, Joao; Tesauro, Manlio

    2014-10-01

    The problems of simulation of bistatic SAR raw data and focusing are studied. A discrete target simulator is described. The simulator introduces the scene topography and compute the integration time of general bistatic configurations providing a means to derived maps of the range and azimuth spatial resolutions. The problem of focusing of bistatic SAR data acquired in a translational-invariant bistatic configuration is studied by deriving the bistatic Point Target Reference spectrum and presenting an analytical solution for its stationary points.

  18. A Focused Bayesian Information Criterion

    OpenAIRE

    Georges Nguefack-Tsague; Ingo Bulla

    2014-01-01

    Myriads of model selection criteria (Bayesian and frequentist) have been proposed in the literature aiming at selecting a single model regardless of its intended use. An honorable exception in the frequentist perspective is the “focused information criterion” (FIC) aiming at selecting a model based on the parameter of interest (focus). This paper takes the same view in the Bayesian context; that is, a model may be good for one estimand but bad for another. The proposed method exploits the Bay...

  19. Focusing Mirror with Tunable Eccentricity

    CERN Document Server

    Stürmer, Moritz; Brunne, Jens; Wallrabe, Ulrike

    2013-01-01

    We present a new kind of varifocal mirror with independently adjustable curvatures in the major directions. For actuation we use two stacked piezo bending actuators with crossed in-plane polarization. This mirror can be used for example as an off-axis focusing device with tunable focal length and compensation for a variable angle of incidence or for coma correction. We demonstrate the prototype of such a mirror and characterize the mechanical deflection, as well as the focusing capabilities.

  20. Verum focus and polar questions

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2012-11-01

    Full Text Available We argue that some word order phenomena in Romanian and Sardinian are the result of a checking operation in the left periphery involving verum focus (i.e. focus on the polarity component of the sentence. In particular, this operation accounts for some word order patterns found in polar questions. In Romanian, polarity fronting is realized as head-movement of (V+T to a higher peripheral head which bears a Focus-probe. This licenses VS orders for predications in which VS is not allowed as a neutral order (i-level predicates, iteratives, generics. In Sardinian, an entire phrase headed by the lexical predicate (verbal non-finite form or non-verbal predicate is fronted before the auxiliary. We argue that this order is obtained by two movement operations, head-raising of Aux to Foc and movement of the predicate phrase to SpecFoc. We also present the semantics of polarity focus, distinguishing several types of focus (informational, emphatic, contrastive.

  1. Speeding chemical reactions by focusing

    CERN Document Server

    Lacasta, A M; Sancho, J M; Lindenberg, K

    2012-01-01

    We present numerical results for a chemical reaction of colloidal particles which are transported by a laminar fluid and are focused by periodic obstacles in such a way that the two components are well mixed and consequently the chemical reaction is speeded up. The roles of the various system parameters (diffusion coefficients, reaction rate, obstacles sizes) are studied. We show that focusing speeds up the reaction from the diffusion limited rate (t to the power -1/2) to very close to the perfect mixing rate, (t to the power -1).

  2. Comparative study of determining IEP and IEP distribution of gelatin with turbidimetry/spectrometry and capillary IEP focusing methods%浊度/分光光度法与毛细管等电点聚焦法测定明胶等电点及其分布的比较研究

    Institute of Scientific and Technical Information of China (English)

    陆扬; 彭必先

    2007-01-01

    The isoelectric point (IEP) is one of the most important physicochemical properties of proteins. There are many different methods for the determination of IEP. In this paper, a comparative study between the simplest turbidimetry/spectrometry method and the most advanced capillary IEP focusing(CaIPF) method was made. Henan cattle hide gelatin's IEP was determined with the two methods and the advantages of the CaIPF method over the other methods were demonstrated and discussed.%等电点是蛋白质最重要的物理化学性质之一.目前有多种测定等电点的方法.本文利用最简单的浊度/分光光度法和最先进的毛细管等电点聚焦法分别测定了河南牛皮明胶的等电点,对两种方法进行比较并论证了后一种方法的优势.

  3. Focus on astronomical predictable events

    DEFF Research Database (Denmark)

    Jacobsen, Aase Roland

    2006-01-01

    At the Steno Museum Planetarium we have for many occasions used a countdown clock to get focus om astronomical events. A countdown clock can provide actuality to predictable events, for example The Venus Transit, Opportunity landing on Mars and The Solar Eclipse. The movement of the clock attracs...

  4. The Road to Focused Logistics

    Science.gov (United States)

    2001-04-10

    The Revolution in Military Logistics (RML) and Focused Logistics requires us to view sustainment needs and requirements in a new perspective. Gone...has taken the tenets of Force XXI, Battlefield Distribution, Velocity Management, Army After Next, and the Revolution In Military Logistics and fused

  5. Focus groups in organizational research

    Directory of Open Access Journals (Sweden)

    L. Kamfer

    1989-05-01

    Full Text Available Focus groups are commonly used in marketing research. In this article an application of the focus group technique within an organizational context is described. Nine focus groups were conducted during the planning stage of a survey intended to establish employee perceptions of advancement policies and practices in a major South African manufacturing company. Fourteen themes emerged from a content analysis of the discussions. Two of these reflected aspects requiring commitment decisions from management toward the survey. The others indicated areas of concern which should be included in the survey. In this way, the focus groups contributed useful information for the subsequent sample survey. Opsomming Fokusgroepe word algemeen in bemarkingsnavorsing aangewend. In hierdie studie word 'n toepassingvan die fokusgroeptegniek in die konteks van 'n opname binne 'n organisasie beskryf. Nege fokusgroepbesprekings is gevoer tydens die beplanningstadium van 'n opname wat binne 'n Suid-Afrikaanse vervaardigingsonderneming gedoen is. Die doel van die opname was om die persepsies van werknemers teenoor die bestaande personeel- en bestuursontwikkelingsbeleid en -praktyke van die maatskappy te bepaal. Veertien temas is deur middel van 'n inhoudontleding gei'dentifiseer. Twee hiervan het aspekte aangedui waaroor bestuur beginselbesluite t.o.v. die opname sou moes neem. Die ander het probleemareas aangedui wat by die ondersoek selfingesluit behoort te word. Sodoende het die fokusgroepe inligting verskafwat vir die latere vraelysopname belangrik was.

  6. Physical Demands Study - Focus Groups

    Science.gov (United States)

    2015-10-26

    and the rounds in the boxes weigh 35 lb, which is lighter than equipment handled in the other physically demanding job tasks already identified...and standards. Ergonomics . 53: 858-871. 40 Appendix A: Questionnaires Completed by Volunteers prior to each Focus Group Interview 1 2 3 4a 4b 5

  7. Evaluating Pragmatics-Focused Materials

    Science.gov (United States)

    Crandall, Elizabeth; Basturkmen, Helen

    2004-01-01

    Learners often find the area of pragmatics (that is, using speech acts such as requesting, inviting, and complimenting) problematic. Teachers are urged to teach pragmatic aspects of language, and make use of authentic samples of spoken discourse to do so. However, information about the effectiveness of pragmatics-focused instruction of this nature…

  8. Technology for Education. IDRA Focus.

    Science.gov (United States)

    IDRA Newsletter, 1998

    1998-01-01

    This theme issue includes five articles that focus on technology for education to benefit all students, including limited-English-proficient, minority, economically disadvantaged, and at-risk students. "Coca-Cola Valued Youth Program Students Meet Peers Via Video Conference" (Linda Cantu, Leticia Lopez-De La Garza) describes how at-risk…

  9. Environmental Protection: a shifting focus

    NARCIS (Netherlands)

    Dr. ir. Jan Venselaar

    2004-01-01

    The last two decades have seen a fundamental change in the way chemistry handles environmental issues. A shift in focus has occurred from 'end-of-pipe' to prevention and process integration. Presently an even more fundamental change is brought about by the need for sustainable development. It is

  10. Focused ion beams in biology.

    Science.gov (United States)

    Narayan, Kedar; Subramaniam, Sriram

    2015-11-01

    A quiet revolution is under way in technologies used for nanoscale cellular imaging. Focused ion beams, previously restricted to the materials sciences and semiconductor fields, are rapidly becoming powerful tools for ultrastructural imaging of biological samples. Cell and tissue architecture, as preserved in plastic-embedded resin or in plunge-frozen form, can be investigated in three dimensions by scanning electron microscopy imaging of freshly created surfaces that result from the progressive removal of material using a focused ion beam. The focused ion beam can also be used as a sculpting tool to create specific specimen shapes such as lamellae or needles that can be analyzed further by transmission electron microscopy or by methods that probe chemical composition. Here we provide an in-depth primer to the application of focused ion beams in biology, including a guide to the practical aspects of using the technology, as well as selected examples of its contribution to the generation of new insights into subcellular architecture and mechanisms underlying host-pathogen interactions.

  11. Verum focus and polar questions

    Directory of Open Access Journals (Sweden)

    Ion Giurgea

    2012-01-01

    Full Text Available We argue that some word order phenomena in Romanian and Sardinian are the result of a checkingoperation in the left periphery involving verum focus (i.e. focus on the polarity component of the sentence.In particular, this operation accounts for some word order patterns found in polar questions. In Romanian,polarity fronting is realized as head-movement of (V+T to a higher peripheral head which bears a Focusprobe.This licenses VS orders for predications in which VS is not allowed as a neutral order (i-levelpredicates, iteratives, generics. In Sardinian, an entire phrase headed by the lexical predicate (verbal nonfiniteform or non-verbal predicate is fronted before the auxiliary. We argue that this order is obtained bytwo movement operations, head-raising of Aux to Foc and movement of the predicate phrase to SpecFoc. Wealso present the semantics of polarity focus, distinguishing several types of focus (informational, emphatic,contrastive.

  12. Focus on "only" and "not"

    CERN Document Server

    Ramsay, A

    1994-01-01

    Krifka [1993] has suggested that focus should be seen as a means of providing material for a range of semantic and pragmatic functions to work on, rather than as a specific semantic or pragmatic function itself. The current paper describes an implementation of this general idea, and applies it to the interpretation of {\\em only} and {\\em not}.

  13. Photographer Puts Family in Focus

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    WITH the rise in the standard of living, the camera—like the television set, the video cassette recorder and the cassette player—has become another essential entertainment tool for families. If you ask young parents who is photographed most in the family, chances are they will readily tell you that the child is the focus.

  14. Brief therapy: focused solution development.

    Science.gov (United States)

    De Shazer, S; Berg, I K; Lipchik, E; Nunnally, E; Molnar, A; Gingerich, W; Weiner-Davis, M

    1986-06-01

    This article describes the form of brief therapy developed at the Brief Family Therapy Center. We have chosen a title similar to Weakland, Fisch, Watzlawick, and Bodin's classic paper, "Brief Therapy: Focused Problem Resolution" (20) to emphasize our view that there is a conceptual relationship and a developmental connection between the points of view expressed in the two papers.

  15. Math Fair: Focus on Fractions

    Science.gov (United States)

    Mokashi, Neelima A.

    2009-01-01

    This article depicts the rewarding experience of creating mathematical environments for kindergarten and elementary students by focusing on one of the most important and often difficult-to-grasp concepts (fractions) through play methods incorporated into a math fair. The basic concept of a math fair is threefold: (1) to create preplanned,…

  16. Algorithms for Labeling Focus Regions.

    Science.gov (United States)

    Fink, M; Haunert, Jan-Henrik; Schulz, A; Spoerhase, J; Wolff, A

    2012-12-01

    In this paper, we investigate the problem of labeling point sites in focus regions of maps or diagrams. This problem occurs, for example, when the user of a mapping service wants to see the names of restaurants or other POIs in a crowded downtown area but keep the overview over a larger area. Our approach is to place the labels at the boundary of the focus region and connect each site with its label by a linear connection, which is called a leader. In this way, we move labels from the focus region to the less valuable context region surrounding it. In order to make the leader layout well readable, we present algorithms that rule out crossings between leaders and optimize other characteristics such as total leader length and distance between labels. This yields a new variant of the boundary labeling problem, which has been studied in the literature. Other than in traditional boundary labeling, where leaders are usually schematized polylines, we focus on leaders that are either straight-line segments or Bezier curves. Further, we present algorithms that, given the sites, find a position of the focus region that optimizes the above characteristics. We also consider a variant of the problem where we have more sites than space for labels. In this situation, we assume that the sites are prioritized by the user. Alternatively, we take a new facility-location perspective which yields a clustering of the sites. We label one representative of each cluster. If the user wishes, we apply our approach to the sites within a cluster, giving details on demand.

  17. A tubular focused sonochemistry reactor

    Institute of Scientific and Technical Information of China (English)

    ZHOU GuangPing; LIANG ZhaoFeng; LI ZhengZhong; ZHANG YiHui

    2007-01-01

    This paper presents a new sonochemistry reactor, which consists of a cylindrical tube with a certain length and piezoelectric transducers at tube's end with the longitudinal vibration. The tube can effectively transform the longitudinal vibration into the radial vibration and thereby generates ultrasound. Furthermore, ultrasound can be focused to form high-intensity ultrasonic field inside tube. The reactor boasts of simple structure and its whole vessel wall can radiate ultrasound so that the electroacoustic transfer efficiency is high. The focused ultrasonic field provides good condition for sonochemical reaction. The length of the reactor can be up to 2 meters, and liquids can pass through it continuously, so it can be widely applied in liquid processing such as sonochemistry.

  18. Reflectors to Focus Wave Energy

    DEFF Research Database (Denmark)

    Kramer, Morten; Frigaard, Peter

    2005-01-01

    Wave Energy Converters (WEC’s) extract wave energy from a limited area, often a single point or line even though the wave energy is generally spread out along the wave crest. By the use of wave reflectors (reflecting walls) the wave energy is effectively focused and increased by approximately 30......-50%. Clearly longer wave reflectors will focus more wave energy than shorter wave reflectors. Thus the draw back is the increased wave forces for the longer wave reflectors. In the paper a procedure for calculating the energy efficiency and the wave forces on the reflectors are described, this by use of a 3D...... boundary element method. The calculations are verified by laboratory experiments and a very good agreement is found. The paper gives estimates of possible power benefit for different wave reflector geometries and optimal geometrical design parameters are specified. On this basis inventors of WEC’s can...

  19. Focus: Simon Steen-Andersen

    DEFF Research Database (Denmark)

    2013), the prize for the best orchestral work at the recently held Doneueschinger Musiktage and The Nordic Council Music Prize in 2014. Seismograf/DMT wishes to celebrate the composer Simon Steen-Andersen. We present and reflect on parts of his comprehensive career, in a Danish and an international...... Rasmus Holmboe; a reflection on the importance of the unrepeatable in Steen-Andersen’s music by composer and PhD Rune Søchting, and a contextualisation of central works by Norwegian editor and writer Ida Habbestad. Our Swedish colleague Andreas Engström writes about the new piano concerto (english....... Watch the trailer. The idea for this Focus comes from Jens Voigt-Lund. It has been realised and edited by Sanne Krogh Groth and Rasmus Holmboe, and published with financial support from Carl Nielsen Fonden. English translations by Helen Clara Hemsley. The Focus is also published in a Danish version....

  20. Focusing properties of linear undulators

    Directory of Open Access Journals (Sweden)

    M. Quattromini

    2012-08-01

    Full Text Available This paper investigates the focusing properties of linear magnetic undulators, i.e., devices characterized by weak defocusing properties in the horizontal (wiggling plane and strongly focusing in the vertical plane. The problem of identifying the conditions that ensure the existence of the electron beam eigenstates in the undulator lattice for a given working point of electron beam energy E_{b} and resonant wavelength λ_{r} is studied. For any given undulator lattice, a bandlike structure is identified defining regions in the (E_{b},λ_{r} plane where no periodic matching condition can be found, i.e., it is not possible to transport the electron beam so that optical functions are periodic at lattice boundaries. Some specific cases are discussed for the SPARC FEL undulator.

  1. Focusing Telescopes in Nuclear Astrophysics

    CERN Document Server

    Ballmoos, Peter von

    2007-01-01

    This volume is the first of its kind on focusing gamma-ray telescopes. Forty-eight refereed papers provide a comprehensive overview of the scientific potential and technical challenges of this nascent tool for nuclear astrophysics. The book features articles dealing with pivotal technologies such as grazing incident mirrors, multilayer coatings, Laue- and Fresnel-lenses - and even an optic using the curvature of space-time. The volume also presents an overview of detectors matching the ambitious objectives of gamma ray optics, and facilities for operating such systems on the ground and in space. The extraordinary scientific potential of focusing gamma-ray telescopes for the study of the most powerful sources and the most violent events in the Universe is emphasized in a series of introductory articles. Practicing professionals, and students interested in experimental high-energy astrophysics, will find this book a useful reference

  2. World Focus on the Moment

    Institute of Scientific and Technical Information of China (English)

    Audrey

    2008-01-01

    @@ Chinese people would never for-get the moment-14:28, on May 12, 2008, as the 8.0-magnitude earthquake shook the whole of Sichuan; at that moment the world's at-tention was focused on the southwest of China - the homeland of the Giant Panda. This rare yet catastrophic natural disaster has resulted in the heavy loss of lives and property throughout the region.

  3. Cherenkov particle identification in FOCUS

    CERN Document Server

    Link, J M; Alimonti, G; Anjos, J C; Arena, V; Bediaga, I; Bianco, S; Boca, G; Bonomi, G; Boschini, M; Butler, J N; Carrillo, S; Casimiro, E; Cawlfield, C; Cheung, H W K; Cho, K; Chung, Y S; Cinquini, L; Cuautle, E; Cumalat, J P; D'Angelo, P; Di Corato, M; Dini, P; Engh, D; Fabbri, Franco Luigi; Gaines, I; Garbincius, P H; Gardner, R; Garren, L A; Giammarchi, M; Gianini, G; Gottschalk, E; Göbel, C; Handler, T; Hernández, H; Hosack, M; Inzani, P; Johns, W E; Kang, J S; Kasper, P H; Kim, D Y; Ko, B R; Kreymer, A E; Kryemadhi, A; Kutschke, R; Kwak, J W; Lee, K B; Leveraro, F; Liguori, G; Magnin, J; Malvezzi, S; Massafferri, A; Menasce, D; Merlo, M M; Mezzadri, M; Milazzo, L; Miranda, J M D; Mitchell, R; Montiel, E; Moroni, L; Méndez, H; Méndez, L; Nehring, M S; O'Reilly, B; Olaya, D; Pantea, D; Paris, A; Park, H; Park, K S; Pedrini, D; Pepe, I M; Pontoglio, C; Prelz, F; Quinones, J; Rahimi, A; Ramírez, J E; Ratti, S P; Reis, A C D; Reyes, M; Riccardi, C; Rivera, C; Rovere, M; Sala, S; Sarwar, S; Segoni, I; Sheaff, M; Sheldon, P D; Stenson, K; Sánchez-Hernández, A; Uribe, C; Vaandering, E W; Vitulo, P; Vázquez, F; Webster, M; Wilson, J R; Wiss, J; Xiong, W; Yager, P M; Zallo, A; Zhang, Y

    2002-01-01

    We describe the algorithm used to identify charged tracks in the fixed-target charm-photoproduction experiment FOCUS. We begin by describing the new algorithm and contrast this approach with that used in our preceding experiment - E687. We next illustrate the algorithm's performance using physics signals. Finally, we briefly describe some of the methods used to monitor the quantum efficiency and noise of the Cherenkov cells.

  4. Cherenkov particle identification in FOCUS

    Energy Technology Data Exchange (ETDEWEB)

    Link, J.M.; Reyes, M.; Yager, P.M.; Anjos, J.C.; Bediaga, I.; Goebel, C.; Magnin, J.; Massafferri, A.; Miranda, J.M. de; Pepe, I.M.; Reis, A.C. dos; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; Cinquini, L.; Cumalat, J.P.; O' Reilly, B.; Ramirez, J.E.; Vaandering, E.W.; Butler, J.N.; Cheung, H.W.K.; Gaines, I.; Garbincius, P.H.; Garren, L.A.; Gottschalk, E.; Kasper, P.H.; Kreymer, A.E.; Kutschke, R.; Bianco, S.; Fabbri, F.L.; Sarwar, S.; Zallo, A.; Cawlfield, C.; Kim, D.Y.; Park, K.S.; Rahimi, A.; Wiss, J. E-mail: jew@uiuc.edu; Gardner, R.; Kryemadhi, A.; Chung, Y.S.; Kang, J.S.; Ko, B.R.; Kwak, J.W.; Lee, K.B.; Park, H.; Alimonti, G.; Boschini, M.; D' Angelo, P.; DiCorato, M.; Dini, P.; Giammarchi, M.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Milazzo, L.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport III, T.F.; Agostino, L.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Merlo, M.M.; Pantea, D.; Ratti, S.P.; Riccardi, C.; Segoni, I.; Vitulo, P.; Hernandez, H.; Lopez, A.M.; Mendez, H.; Mendez, L.; Montiel, E.; Olaya, D.; Paris, A.; Quinones, J.; Rivera, C.; Xiong, W.; Zhang, Y.; Wilson, J.R.; Cho, K.; Handler, T.; Mitchell, R.; Engh, D.; Johns, W.E.; Hosack, M.; Nehring, M.S.; Sheldon, P.D.; Stenson, K.; Webster, M.S.; Sheaff, M

    2002-05-21

    We describe the algorithm used to identify charged tracks in the fixed-target charm-photoproduction experiment FOCUS. We begin by describing the new algorithm and contrast this approach with that used in our preceding experiment - E687. We next illustrate the algorithm's performance using physics signals. Finally, we briefly describe some of the methods used to monitor the quantum efficiency and noise of the Cherenkov cells.

  5. Focus On Photoshop Elements Focus on the Fundamentals

    CERN Document Server

    Asch, David

    2011-01-01

    Are you bewildered by the advanced editing options available in Photoshop Elements? Do you want to get the most out of your image without going bleary-eyed in front of a computer screen? This handy guide will explain the ins and outs of using Photoshop Elements, without having to spend hours staring at the screen. Using a fabulous combination of easy-to-follow advice and step-by-step instructions, Focus On Photoshop Elements gives great advice on setting up, storing and sharing your image library and teaches you the basics of RAW image processing and color correction, plus shows you how to edi

  6. The quest for customer focus.

    Science.gov (United States)

    Gulati, Ranjay; Oldroyd, James B

    2005-04-01

    Companies have poured enormous amounts of money into customer relationship management, but in many cases the investment hasn't really paid off. That's because getting closer to customers isn't about building an information technology system. It's a learning journey-one that unfolds over four stages, requiring people and business units to coordinate in progressively more sophisticated ways. The journey begins with the creation of a companywide repository containing each interaction a customer has with the company, organized not by product, purchase, or location, but by customer. Communal coordination is what's called for at this stage, as each group contributes its information to the data pool separately from the others and then taps into it as needed. In the second stage, one-way serial coordination from centralized IT through analytical units and out to the operating units allows companies to go beyond just assembling data to drawing inferences. In stage three, companies shift their focus from past relationships to future behavior. Through symbiotic coordination, information flows back and forth between central analytic units and various organizational units like marketing, sales, and operations, as together they seek answers to questions like "How can we prevent customers from switching to a competitor?" and "Who would be most likely to buy a new product in the future"? In stage four, firms begin to move past discrete, formal initiatives and, through integral coordination, bring an increasingly sophisticated understanding oftheir customers to bear in all day-to-day operations. Skipping stages denies organizations the sure foundation they need to build a lasting customer-focused mind-set. Those that recognize this will invest their customer relationship dollars much more wisely-and will see their customer-focusing efforts pay offon the bottom line.

  7. Final focus system for TLC

    Energy Technology Data Exchange (ETDEWEB)

    Oide, K.

    1988-11-01

    A limit of the chromaticity correction for the final focus system of a TeV Linear Collider (TLC) is investigated. As the result, it becomes possible to increase the aperture of the final doublet with a small increase of the horizontal US function. The new optics design uses a final doublet of 0.5 mm half-aperture and 1.4 T pole-tip field. The length of the system is reduced from 400 m to 200 m by several optics changes. Tolerances for various machine errors with this optics are also studied. 5 refs., 7 figs., 2 tabs.

  8. Clinical focus: infections in pregnancy.

    Science.gov (United States)

    Adler, Hugh; Lambert, John S

    2014-04-01

    Pregnant women are particularly susceptible to a number of infectious diseases, such as influenza, hepatitis E, malaria, and tuberculosis. The management of many other infections-including urinary tract infections, human immunodeficiency virus, and sexually transmitted diseases-is also made more complex by pregnancy; even if some infections do not pose a great risk to the expectant mother, they can impact fetal and neonatal development, thus posing a treatment challenge to physicians. By focusing on the most important diseases that physicians may encounter in pregnant patients, this review outlines the challenges associated with managing important infectious diseases in the pregnant population and references the most recent evidence and international treatment guidelines.

  9. Prime focus spectrograph: Subaru's future

    OpenAIRE

    Sugai, Hajime; Dekany, Richard G.; Ellis, Richard S.; Seiffert, Michael D.; Smith, Roger M.

    2012-01-01

    The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru’s wide field of view, which is further extended with the recently completed Wide Fie...

  10. Focusing properties of mushroom microlenses

    CERN Document Server

    Boriskin, A V; Benson, T; Sewell, P; Nosich, A I

    2010-01-01

    Focusing properties of a novel type photoresist microlens are studied. A specific character of the microlens is its mushroom shape. Recently it was predicted and experimentally revealed that such a lens integrated with a light-emitting diode is capable of enhancing its output efficiency and directivity. In our paper we describe the true electromagnetic performance of a mushroom lens by applying a mathematically rigorous method of boundary integral equations. Numerical results are presented for the mushroom lens illuminated with a plane E-polarized wave and include figures describing the evolution of the lens focal spot and near field maps.

  11. Bayesian Query-Focused Summarization

    CERN Document Server

    Daumé, Hal

    2009-01-01

    We present BayeSum (for ``Bayesian summarization''), a model for sentence extraction in query-focused summarization. BayeSum leverages the common case in which multiple documents are relevant to a single query. Using these documents as reinforcement for query terms, BayeSum is not afflicted by the paucity of information in short queries. We show that approximate inference in BayeSum is possible on large data sets and results in a state-of-the-art summarization system. Furthermore, we show how BayeSum can be understood as a justified query expansion technique in the language modeling for IR framework.

  12. A focused bibliography on robotics

    Science.gov (United States)

    Mergler, H. W.

    1983-08-01

    The present bibliography focuses on eight robotics-related topics believed by the author to be of special interest to researchers in the field of industrial electronics: robots, sensors, kinematics, dynamics, control systems, actuators, vision, economics, and robot applications. This literature search was conducted through the 1970-present COMPENDEX data base, which provides world-wide coverage of nearly 3500 journals, conference proceedings and reports, and the 1969-1981 INSPEC data base, which is the largest for the English language in the fields of physics, electrotechnology, computers, and control.

  13. Design for a focusing high-resolution neutron crystal diffractometer

    CERN Document Server

    Ionita, I; Popovici, M; Popa, N C

    1999-01-01

    A new concept of high-resolution focusing configuration begins to be accepted as an alternative solution to the existing conventional configurations. Among the earliest work performed in this direction is that performed at the Institute for Nuclear Research, Pitesti. These results are presented below. The experimentally determined resolution properties for two focusing configurations obtained at TRIGA reactor Pitesti and at VVRS reactor Bucharest are given in order to be compared with those obtained for the conventional ones. The principles to get focusing in crystal neutron diffractometry are presented. The main characteristics for a focusing instrument are given. (author)

  14. Plutonium focus area. Technology summary

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The Assistant Secretary for the Office of Environmental Management (EM) at the U.S. Department of Energy (DOE) chartered the Plutonium Focus Area (PFA) in October 1995. The PFA {open_quotes}...provides for peer and technical reviews of research and development in plutonium stabilization activities...{close_quotes} In addition, the PFA identifies and develops relevant research and technology. The purpose of this document is to focus attention on the requirements used to develop research and technology for stabilization, storage, and preparation for disposition of nuclear materials. The PFA Technology Summary presents the approach the PFA uses to identify, recommend, and review research. It lists research requirements, research being conducted, and gaps where research is needed. It also summarizes research performed by the PFA in the traditional research summary format. This document encourages researchers and commercial enterprises to do business with PFA by submitting research proposals or {open_quotes}white papers.{close_quotes} In addition, it suggests ways to increase the likelihood that PFA will recommend proposed research to the Nuclear Materials Stabilization Task Group (NMSTG) of DOE.

  15. On highly focused supersonic microjets

    CERN Document Server

    Tagawa, Yoshiyuki; Willem, Claas; Peters, Ivo R; van der Meer, Deveraj; Sun, Chao; Prosperetti, Andrea; Lohse, Detlef

    2011-01-01

    By focusing a laser pulse in a liquid-filled glass-microcapillary open at one end, a small mass of liquid is instantaneously vapourised. This leads to a shock wave which travels towards the concave free surface where it generates a high-speed microjet. The initial shape of the meniscus plays a dominant role in the process. The velocity of the jet can reach supersonic speeds up to 850\\,m/s while maintaining a very sharp geometry. The entire evolution of the jet is observed by high-speed recordings of up to $10^6\\,$fps. A parametric study of the jet velocity as a function of the contact angle of the liquid-glass interface, the energy absorbed by the liquid, the diameter of the capillary tube, and the distance between the laser focus and the free surface is performed, and the results are rationalised. The method could be used for needle-free injection of vaccines or drugs.

  16. Future focus for professional development.

    Science.gov (United States)

    Roberts, Nicole K; Coplit, Lisa D

    2013-01-01

    Professional development has evolved from individually focused sabbaticals and professional leaves to institutionally focused programs with an interest in developing faculty members' ability to teach in various environments as well as to succeed in the many endeavors they undertake. We address various issues related to professional development in the medical school arena. Professional development in medical school takes place in a context where faculty are stretched to engage in research and service not only for their own sake but also to financially support their institutions. This obligates professional developers to acknowledge and address the environments in which teaching faculty work, and to use approaches to professional development that honor the time and efforts of teaching faculty. These approaches may be brief interventions that make use of principles of education, and may include online offerings. Professional development will be most effective when professional developers acknowledge that most faculty members aspire to excellence in teaching, but they do so in an environment that pushes them to address competing concerns. Offering professional development opportunities that fit within the workplace environment, take little time, and build upon faculty's existing knowledge will assist in enhancing faculty success.

  17. Tsunami Focusing and Leading Amplitude

    Science.gov (United States)

    Kanoglu, U.

    2016-12-01

    Tsunamis transform substantially through spatial and temporal spreading from their source region. This substantial spreading might result unique maximum tsunami wave heights which might be attributed to the source configuration, directivity, the waveguide structures of mid-ocean ridges and continental shelves, focusing and defocusing through submarine seamounts, random focusing due to small changes in bathymetry, dispersion, and, most likely, combination of some of these effects. In terms of the maximum tsunami wave height, after Okal and Synolakis (2016 Geophys. J. Int. 204, 719-735), it is clear that dispersion would be one of the reasons to drive the leading wave amplitude in a tsunami wave train. Okal and Synolakis (2016), referring to this phenomenon as sequencing -later waves in the train becoming higher than the leading one, considered Hammack's (1972, Ph.D. Dissertation, Calif. Inst. Tech., 261 pp) formalism, in addition to LeMéhauté and Wang's (1995 Water waves generated by underwater explosion, World Scientific, 367 pp), to evaluate linear dispersive tsunami propagation from a circular plug uplifted on an ocean of constant depth. They identified transition distance, as the second wave being larger, performing parametric study for the radius of the plug and the depth of the ocean. Here, we extend Okal and Synolakis' (2016) analysis to an initial wave field with a finite crest length and, in addition, to a most common tsunami initial wave form of N-wave (Tadepalli and Synolakis, 1994 Proc. R. Soc. A: Math. Phys. Eng. Sci. 445, 99-112). First, we investigate the focusing feature in the leading-depression side, which enhance tsunami wave height as presented by Kanoglu et al. (2013 Proc. R. Soc. A: Math. Phys. Eng. Sci. 469, 20130015). We then discuss the results in terms of leading wave amplitude presenting a parametric study and identify a simple relation for the transition distance. The solution presented here could be used to better analyze dispersive

  18. Determinant factors for malaria transmission on the coast of Oaxaca State, the main residual transmission focus in Mexico Factores determinantes de la transmisión de paludismo en la costa del estado de Oaxaca, el principal foco residual de transmisión en México

    Directory of Open Access Journals (Sweden)

    Juan E Hernández-Avila

    2006-10-01

    Full Text Available OBJECTIVE: The purpose of this study was to investigate the influence of demographic, socioeconomic and ecological factors in malaria transmission in the most important residual transmission focus in Mexico, located in the state of Oaxaca. MATERIAL AND METHODS: The extension of the focus was determined by a spatial and time analysis of the distribution of malaria cases in the state between 1998 and 1999 using a Geographical Information System. A malaria transmission intensity index (MTII was constructed based on the total number of cases during the study period and the duration and frequency of transmission outbreaks within the villages. The relationship between local determinants and malaria transmission intensity was investigated using multinomial and ordered logistic models. RESULTS: The distribution of villages according to their MTII was: 325 high, 341 medium, 142 low and 717 with no transmission. Localities of high MTII were associated with areas having a tropical climate with summer rains and low water evaporation. Most high MTII villages were located in elevations between 200 and 500 m above sea level, in the area around Pochutla City. The amount of temporary streams in the neighborhood of localities had a highly significant positive association with the MTII. Distance to roads was only significant in the high malaria MTII stratum. CONCLUSIONS: The main factors determining malaria transmission in the focus are related to good conditions for the breeding of mosquito vectors. The existence of short-range population movements around Pochutla, the main economically active city in the area, indicates the necessity to implement a system of epidemiological surveillance to halt the dispersion of new outbreaks.OBJETIVO: Investigar la participación de factores demográficos, socio-económicos y ecológicos en la transmisión de la malaria en el foco de transmisión residual más importante en México, localizado en el estado de Oaxaca. MATERIAL Y

  19. Focusing X-Ray Telescopes

    Science.gov (United States)

    O'Dell, Stephen; Brissenden, Roger; Davis, William; Elsner, Ronald; Elvis, Martin; Freeman, Mark; Gaetz, Terrance; Gorenstein, Paul; Gubarev, Mikhall; Jerlus, Diab; Juda, Michael; Kolodziejczak, Jeffrey; Murray, Stephen; Petre, Robert; Podgorski, William; Ramsey, Brian; Reid, Paul; Saha, Timo; Wolk, Scott; Troller-McKinstry, Susan; Weisskopf, Martin; Wilke, Rudeger; Zhang, William

    2010-01-01

    During the half-century history of x-ray astronomy, focusing x-ray telescopes, through increased effective area and finer angular resolution, have improved sensitivity by 8 orders of magnitude. Here, we review previous and current x-ray-telescope missions. Next, we describe the planned next-generation x-ray-astronomy facility, the International X-ray Observatory (IXO). We conclude with an overview of a concept for the next next-generation facility, Generation X. Its scientific objectives will require very large areas (about 10,000 sq m) of highly-nested, lightweight grazing-incidence mirrors, with exceptional (about 0.1-arcsec) resolution. Achieving this angular resolution with lightweight mirrors will likely require on-orbit adjustment of alignment and figure.

  20. Micron-focused ion beamlets

    Science.gov (United States)

    Chowdhury, Abhishek; Bhattacharjee, Sudeep

    2010-05-01

    A multiple beam electrode system (MBES) is used to provide focused ion beamlets of elements from a compact microwave plasma. In this study, a honeycomb patterned plasma electrode with micron size apertures for extracting ion beamlets is investigated. The performance of the MBES is evaluated with the help of two widely adopted and commercially available beam simulation tools, AXCEL-INP and SIMION, where the input parameters are obtained from our experiments. A simple theoretical model based upon electrostatic ray optics is employed to compare the results of the simulations. It is found that the results for the beam focal length agree reasonably well. Different geometries are used to optimize the beam spot size and a beam spot ˜5-10 μm is obtained. The multiple ion beamlets will be used to produce microfunctional surfaces on soft matter like polymers. Additionally, the experimental set-up and plans are presented in the light of above applications.

  1. TwinFocus CPV system

    Science.gov (United States)

    Nardello, Marco; Centro, Sandro

    2017-09-01

    TwinFocus® is a CPV solution that adopts quasi-parabolic, off axis mirrors, to obtain a concentration of 760× on 3J solar cells (Azur space technology) with 44% efficiency. The adoption of this optical solution allows for a cheap, lightweight and space efficient system. In particular, the addition of a secondary optics to the mirror, grants an efficient use of space, with very low thicknesses and a compact modular design. Materials are recyclable and allow for reduction of weights to a minimum level. The product is realized through the cooperation of leading edge industries active in automotive lighting and plastic materials molding. The produced prototypes provide up to 27.6% efficiency according to tests operated on the field with non-optimal spectral conditions.

  2. Megaloblastic anemia: back in focus.

    Science.gov (United States)

    Chandra, Jagdish

    2010-07-01

    Megaloblastic anemia (MA), in most instances in developing countries, results from deficiency of vitamin B(12) or folic acid. Over the last two to three decades, incidence of MA seems to be increasing. Of the two micronutrients, folic acid deficiency contributed to MA in a large majority of cases. Now deficiency of B(12) is far more common. In addition to anemia, occurrence of neutropenia and/or thrombocytopenia is increasingly being reported. Among cases presenting with pancytopenia, MA stands out as an important (commonest cause in some series) cause. This article focuses on these and certain other aspects of MA. Possible causes of increasing incidence of MA are discussed. Observations on other clinical features like neurocognitive dysfunction, associated hyperhomocysteinemeia and occurrence of tremors and thrombocytosis during treatment are highlighted.

  3. Non-imaging, focusing heliostat

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y.T.; Chong, K.K.; Bligh, T.P. [Univ. of Technology Malaysia, Faculty of Electrical Engineering, Johor (MY)] [and others

    2001-07-01

    A non-imaging focusing heliostat for effective use of thermal solar energy is proposed. The heliostat consists of a number of grouped slave mirrors, which are able to move according to a proposed formula to eliminate the first order aberration. The master tracks the sun by a proposed rotation-elevation mode to project solar rays together with the rest of slave mirrors into a fixed target. The merit of this design is that if may benefit the use of solar energy in high temperature applications by allowing a single stage collector to replace a conventional double stage structure; it may also benefit high concentration applications, e.g., solar powered Stirling engines, solar pumped lasers, etc. The feasibility and a reliability test of the proposed method by a prototype heliostat in the University of Technology, Malaysia is reported. (Author)

  4. Focus on Nivolumab in NSCLC

    Science.gov (United States)

    Cortinovis, Diego L.; Canova, Stefania; Abbate, Marida; Colonese, Francesca; Bidoli, Paolo

    2016-01-01

    Immunotherapy is changing the treatment of non-small cell lung cancer (NSCLC). The PD-1 inhibitor nivolumab has demonstrated meaningful results in terms of efficacy with a good safety profile. The novel approach to treating NSCLC using immunotherapy still has unsolved questions and challenging issues. The main doubts regarding the optimal selection of the patient are the role of this drug in first line of treatment, the individualization of the correct methodology of radiologic assessment and efficacy analysis, the best management of immune-mediated adverse events, and how to overcome the immunoresistance. The aim of this review is to analyze literature data on nivolumab in lung cancer with a focus on critical aspects related to the drug in terms of safety, the use in clinical practice, and possible placement in the treatment algorithm. PMID:28018902

  5. Focusing telescopes in nuclear astrophysics

    Energy Technology Data Exchange (ETDEWEB)

    Von Ballmoos, P.; Knodlseder, R.; Sazonov, S.; Griffiths, R.; Bastie, P.; Halloin, H.; Pareschi, G.; Ramsey, B.; Jensen, C.; Buis, E.J.; Ulmer, M.; Giommi, P.; Colafrancesco, S.; Comastri, A.; Barret, D.; Leising, M.; Hernanz, M.; Smith, D.; Abrosimov, N.; Smither, B.; Ubertini, P.; Olive, J.F.; Lund, N.; Pisa, A.; Courtois, P.; Roa, D.; Harrison, F.; Pareschi, G.; Frontera, F.; Von Ballmoos, P.; Barriere, N.; Rando, N.; Borde, J.; Hinglais, E.; Cledassou, R.; Duchon, P.; Sghedoni, M.; Huet, B.; Takahashi, T.; Caroli, E.; Quadrinin, L.; Buis, E.J.; Skinner, G.; Krizmanic, J.; Pareschi, G.; Loffredo, G.; Wunderer, C.; Weidenspointner, G.; Wunderer, C.; Koechlin, L.; Bignami, G.; Von Ballmoos, P.; Tueller, J.; Andritschke, T.; Laurens, A.; Evrard, J

    2005-07-01

    The objective of this workshop is to consider the next generation of instrumentation to be required within the domain of nuclear astrophysics. A small, but growing community has been pursuing various techniques for the focusing of hard X-rays and gamma-rays with the aim of achieving a factor of up to 100 improvement in sensitivity over present technologies. Balloon flight tests of both multilayer mirrors and a Laue lens have been performed and ideas abound. At present, implementation scenarios for space missions are being studied at Esa, CNES, and elsewhere. The workshop will provide a first opportunity for this new community to meet, exchange technological know-how, discuss scientific objectives and synergies, and consolidate implementation approaches within National and European Space Science programs. This document gathers the slides of all the presentations.

  6. Ultrasound focusing images in superlattices

    Energy Technology Data Exchange (ETDEWEB)

    Narita, Michiko; Tanaka, Yukihiro; Tamura, Shin-ichiro [Department of Applied Physics, Hokkaido University, Sapporo (Japan)

    2002-03-04

    We study theoretically ultrasound focusing in periodic multilayered structures, or superlattices, by solving the wave equation with the Green function method and calculating the transmitted ultrasound amplitude images of both the longitudinal and transverse modes. The constituent layers assumed are elastically isotropic but the periodically stacked structure is anisotropic. Thus anisotropy of ultrasound propagation is predicted even at low frequencies and it is enhanced significantly at higher frequencies due to the zone-folding effect of acoustic dispersion relations. An additional effect studied is the interference of ultrasound (known as the internal diffraction), which can be recognized when the propagation distance is comparable to the ultrasound wavelength. Numerical examples are developed for millimetre-scale Al/polymer multilayers used recently for imaging experiment with surface acoustic waves. (author)

  7. EDITORIAL: Focus on Cloud Physics FOCUS ON CLOUD PHYSICS

    Science.gov (United States)

    Falkovich, Gregory; Malinowski, Szymon P.

    2008-07-01

    Cloud physics has for a long time been an important segment of atmospheric science. It is common knowledge that clouds are crucial for our understanding of weather and climate. Clouds are also interesting by themselves (not to mention that they are beautiful). Complexity is hidden behind the common picture of these beautiful and interesting objects. The typical school textbook definition that a cloud is 'a set of droplets or particles suspended in the atmosphere' is not adequate. Clouds are complicated phenomena in which dynamics, turbulence, microphysics, thermodynamics and radiative transfer interact on a wide range of scales, from sub-micron to kilometres. Some of these interactions are subtle and others are more straightforward. Large and small-scale motions lead to activation of cloud condensation nuclei, condensational growth and collisions; small changes in composition and concentration of atmospheric aerosol lead to significant differences in radiative properties of the clouds and influence rainfall formation. It is justified to look at a cloud as a composite, nonlinear system which involves many interactions and feedback. This system is actively linked into a web of atmospheric, oceanic and even cosmic interactions. Due to the complexity of the cloud system, present-day descriptions of clouds suffer from simplifications, inadequate parameterizations, and omissions. Sometimes the most fundamental physics hidden behind these simplifications and parameterizations is not known, and a wide scope of view can sometimes prevent a 'microscopic', deep insight into the detail. Only the expertise offered by scientists focused on particular elementary processes involved in this complicated pattern of interactions allows us to shape elements of the puzzle from which a general picture of clouds can be created. To be useful, every element of the puzzle must be shaped precisely. This often creates problems in communication between the sciences responsible for shaping

  8. In-focus quantitative intensity and phase imaging with the numerical focusing transport of intensity equation method

    Science.gov (United States)

    Tian, Xiaolin; Meng, Xin; Yu, Wei; Song, Xiaojun; Xue, Liang; Liu, Cheng; Wang, Shouyu

    2016-10-01

    Microscopy combined with the transport of intensity equation is capable of retrieving both intensity and phase distributions of samples from both in-focus and defocus intensities. However, during measurements, the focal plane is often decided artificially and the improper choice may induce errors in quantitative intensity and phase retrieval. In order to obtain accurate in-focus information, quantitative intensity and phase imaging with the numerical focusing transport of intensity equation method combined with cellular duty ratio criterion and numerical wavefront propagation is introduced in this paper. Both numerical simulations and experimental measurements are provided proving this designed method can increase both retrieved in-focus intensity and phase accuracy and reduce dependence of focal plane determination in transport of intensity equation measurements. It is believed that the proposed method can be potentially applied in various fields as in-focus compensation for quantitative phase imaging and automatic focal plane determination, etc.

  9. Focus groups: a strategy for health research

    Directory of Open Access Journals (Sweden)

    Maria da Graça Kfouri LOPES

    2010-06-01

    Full Text Available Introduction: The research strategy through open interviews is a qualitative alternative that can capture the meaning embedded in opinions expressed, revealing values and feelings of the research subjects. As a constructivist method it requires the interpretative analysis of the speech. Data collection requires pragmatism from the researcher and absence of stimuli that might induce or inhibit the interviewees. Objective: This study had the following proposals: a to implement the strategy of focus groups as part of the evaluation of the Qualitative Methods discipline in a stricto sensu course; b to search the criteria that determine the patient’s choice of dental professional.Material and methods: In order to achieve the objectives of the research,an exercise was carried out aimed at understanding the content of focus groups through active learning methodology based on the experience and binomial action-reflection. The activity was developed under the theme “Determinants in the relationship established between the dental professional and their patients”, according to the patients’ opinions.The group that coordinated the activity consisted of four dentists,students of the Qualitative Methods discipline, who played the following roles: a mediator; b reporter; c observer; d recording operator.The discussion group was composed of six (N = 6 volunteers from a total of 20 students enrolled in this discipline. The exclusion criteria included those with private dental plans and/or the exclusive users of public health services. The recording was transcribed and submitted to content analysis. To this end the ATLAS.ti 5.0 computer program was used. Results: Patients select the dental professional according to the references they get from others. The personal relationship was highly valued by the group, reinforcing the skills and abilities of sensitivity and commitment to the human being presented in the text of the National Curriculum Guidelines

  10. Findings: LANL outsourcing focus groups

    Energy Technology Data Exchange (ETDEWEB)

    Jannotta, M.J.; McCabe, V.B.

    1996-12-31

    In March 1996, a series of 24 3-hour dialog focus groups were held with randomly selected Laboratory employees and contractors to gain their perceptions regarding potentials and problems for privatization and consolidation. A secondary goal was to educate and inform the workforce about potentials and issues in privatization and consolidation. Two hundred and thirty-six participants engaged in a learning session and structured input exercises resulting in 2,768 usable comments. Comments were categorized using standard qualitative methods; resulting categories included positive and negative comments on four models (consolidation, spin offs, outsourcing, and corporate partnering) and implications for the workforce, the Laboratory, and the local economy. Categories were in the areas of increasing/decreasing jobs, expertise, opportunity/salary/benefits, quality/efficiency, and effect on the local area and economy. An additional concern was losing Laboratory culture and history. Data were gathered and categorized on employee opinion regarding elements of successful transition to the four models, and issues emerged in the areas of terms and conditions of employment; communication; involvement; sound business planning; ethics and fairness; community infrastructure. From the aggregated opinion of the participants, it is recommended that decision-makers: Plan using sound business principles and continually communicate plans to the workforce; Respect workforce investments in the Laboratory; Tell the workforce exactly what is going on at all times; Understand that economic growth in Northern New Mexico is not universally viewed as positive; and Establish dialog with stakeholders on growth issues.

  11. Patient satisfaction: focusing on "excellent".

    Science.gov (United States)

    Otani, Koichiro; Waterman, Brian; Faulkner, Kelly M; Boslaugh, Sarah; Burroughs, Thomas E; Dunagan, W Claiborne

    2009-01-01

    In an emerging competitive market such as healthcare, managers should focus on achieving excellent ratings to distinguish their organization from others. When it comes to customer loyalty, "excellent" has a different meaning. Customers who are merely satisfied often do not come back. The purpose of this study was to find out what influences adult patients to rate their overall experience as "excellent." The study used patient satisfaction data collected from one major academic hospital and four community hospitals. After conducting a multiple logistic regression analysis, certain attributes were shown to be more likely than others to influence patients to rate their experiences as excellent. The study revealed that staff care is the most influential attribute, followed by nursing care. These two attributes are distinctively stronger drivers of overall satisfaction than are the other attributes studied (i.e., physician care, admission process, room, and food). Staff care and nursing care are under the control of healthcare managers. If improvements are needed, they can be accomplished through training programs such as total quality management or continuous quality improvement, through which staff employees and nurses learn to be sensitive to patients' needs. Satisfying patients' needs is the first step toward having loyal patients, so hospitals that strive to ensure their patients are completely satisfied are more likely to prosper.

  12. Prime Focus Spectrograph - Subaru's future -

    CERN Document Server

    Sugai, Hajime; Takato, Naruhisa; Tamura, Naoyuki; Shimono, Atsushi; Ohyama, Youichi; Ueda, Akitoshi; Ling, Hung-Hsu; de Arruda, Marcio Vital; Barkhouser, Robert H; Bennett, Charles L; Bickerton, Steve; Braun, David F; Bruno, Robin J; Carr, Michael A; Oliveira, João Batista de Carvalho; Chang, Yin-Chang; Chen, Hsin-Yo; Dekany, Richard G; Dominici, Tania Pereira; Ellis, Richard S; Fisher, Charles D; Gunn, James E; Heckman, Timothy M; Ho, Paul T P; Hu, Yen-Shan; Jaquet, Marc; Karr, Jennifer; Kimura, Masahiko; Fèvre, Olivier Le; Mignant, David Le; Loomis, Craig; Lupton, Robert H; Madec, Fabrice; Marrara, Lucas Souza; Martin, Laurent; Murayama, Hitoshi; de Oliveira, Antonio Cesar; de Oliveira, Claudia Mendes; de Oliveira, Ligia Souza; Orndorff, Joe D; Vilaça, Rodrigo de Paiva; Macanhan, Vanessa Bawden de Paula; Prieto, Eric; Santos, Jesulino Bispo dos; Seiffert, Michael D; Smee, Stephen A; Smith, Roger M; Sodré, Laerte; Spergel, David N; Surace, Christian; Vives, Sebastien; Wang, Shiang-Yu; Yan, Chi-Hung

    2012-01-01

    The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru's wide field of view, which is further extended with the recently completed Wide Field Corrector, PFS will enable us to carry out multi-fiber spectroscopy of 2400 targets within 1.3 degree diameter. A microlens is attached at each fiber entrance for F-ratio transformation into a larger one so that difficulties of spectrograph design are eased. Fibers are accurately placed onto target positions by positioners, each of which consists of two stages of piezo-electric rotary motors, through iterations by using back-illuminated fiber position measurements with a wide-field metrology camera. Fibers then carry l...

  13. Focus+context metro maps.

    Science.gov (United States)

    Wang, Yu-Shuen; Chi, Ming-Te

    2011-12-01

    We introduce a focus+context method to visualize a complicated metro map of a modern city on a small displaying area. The context of our work is with regard the popularity of mobile devices. The best route to the destination, which can be obtained from the arrival time of trains, is highlighted. The stations on the route enjoy larger spaces, whereas the other stations are rendered smaller and closer to fit the whole map into a screen. To simplify the navigation and route planning for visitors, we formulate various map characteristics such as octilinear transportation lines and regular station distances into energy terms. We then solve for the optimal layout in a least squares sense. In addition, we label the names of stations that are on the route of a passenger according to human preferences, occlusions, and consistencies of label positions using the graph cuts method. Our system achieves real-time performance by being able to report instant information because of the carefully designed energy terms. We apply our method to layout a number of metro maps and show the results and timing statistics to demonstrate the feasibility of our technique. © 2011 IEEE

  14. SIAM Workshop: Focus on Diversity

    Energy Technology Data Exchange (ETDEWEB)

    None

    2000-07-12

    The Fourth SlAM Graduate Student Focus on Diversity workshop was held on July 12, 2000 at the Westin Rio Mar Hotel in Rio Grande, Puerto Rico. The Department of Energy provided partial support for this event. The day-long workshop consisted of several different activities. The meeting opened with a discussion of some data collected by the American Mathematical Society on Ph.D.'s awarded in the U.S. to citizens and non-citizens, further classified as blacks, latinos, asians and native americans. The activity continued with nine technical talks by underrepresented minority graduate students, informal luncheon and pizza breaks to foster social interaction, and an evening forum chaired by Dr. Richard Tapia (Rice University) in which issues related to the participation of minorities in national meetings and proposal writing where discussed. These sessions were open to the entire SIAM community and served to highlight the progress, achievements, and aspirations of the workshop participants. The students attended as well the three SlAM plenary talks during the day and the community lecture in the evening. The activity had a lively participation of students and representatives from various academic institutions and sponsoring agencies. In particular, we had the participation of 24 undergraduate students from the Mathematics REU program of the University of Puerto Rico at Humacao.

  15. Focus issue introduction: nonlinear photonics.

    Science.gov (United States)

    Akhmediev, Nail; Rottwitt, Karsten

    2012-11-19

    It is now 23 years since the first Topical Meeting "Nonlinear Guided Wave Phenomena" (Houston, TX, February 2-4, 1989) has been organised by George Stegeman and Allan Boardman with support of the Optical Society of America. These series of the OSA conferences known as NLGW, continued under the name "Nonlinear Photonics" starting from 2007. The latest one, in Colorado Springs in June 17-21, 2012 has been a great success despite the fierce fires advancing around the city at the time of the conference. This Focus issue is a collection of several papers presented at the conference with extended content submitted to Optics Express. Although this collection is small in comparison to the total number of papers presented at the conference, it gives a flavor of the topics considered at the meeting. It is also worthy to mention here that the next meeting "Nonlinear Photonics" is planned to be held in Barcelona - one of the main European centers on this subject.

  16. A process for risk-focused maintenance

    Energy Technology Data Exchange (ETDEWEB)

    Lofgren, E.V.; Cooper, S.E.; Kurth, R.E.; Phillips, L.B. (Science Applications International Corp., McLean, VA (USA))

    1991-03-01

    This report presents a process for focusing maintenance resources on components that enable nuclear plant systems to perform their essential functions and on components whose failure may initiate challenges to safety systems, so as to have the greatest impact in decreasing risk. The process provides criteria, based on risk, for deciding which components are critical to risk and determining what maintenance activities are required to ensure reliable operation of those risk-critical components. Two approaches are provided for selection of risk-critical components. One approach uses the results of a Probabilistic Risk Assessment (PRA); the other is based on the methodology developed for this report, which has a basis in PRA although it does not use the results of a PRA study. Following identification of risk-critical components, both approaches use a single methodology for determining what maintenance activities are required to ensure reliable operation of the identified components. The report also provides demonstrations of application of the two approaches to selection of risk-critical components and demonstrations of application of the methodology for determining what maintenance activities are required to an active standby safety system, a normally operating system, and passive components. 5 refs., 11 figs., 1 tab.

  17. Fredholm's equations for subwavelength focusing

    Science.gov (United States)

    Velázquez-Arcos, J. M.

    2012-10-01

    Subwavelength focusing (SF) is a very useful tool that can be carried out with the use of left hand materials for optics that involve the range of the microwaves. Many recent works have described a successful alternative procedure using time reversal methods. The advantage is that we do not need devices which require the complicated manufacture of left-hand materials; nevertheless, the theoretical mathematical bases are far from complete because before now we lacked an adequate easy-to-apply frame. In this work we give, for a broad class of discrete systems, a solid support for the theory of electromagnetic SF that can be applied to communications and nanotechnology. The very central procedure is the development of vector-matrix formalism (VMF) based on exploiting both the inhomogeneous and homogeneous Fredholm's integral equations in cases where the last two kinds of integral equations are applied to some selected discrete systems. To this end, we first establish a generalized Newmann series for the Fourier transform of the Green's function in the inhomogeneous Fredholm's equation of the problem. Then we go from an integral operator equation to a vector-matrix algebraic one. In this way we explore the inhomogeneous case and later on also the very interesting one about the homogeneous equation. Thus, on the one hand we can relate in a simple manner the arriving electromagnetic signals with those at their sources and we can use them to perform a SF. On the other hand, we analyze the homogeneous version of the equations, finding resonant solutions that have analogous properties to their counterparts in quantum mechanical scattering, that can be used in a proposed very powerful way in communications. Also we recover quantum mechanical operator relations that are identical for classical electromagnetics. Finally, we prove two theorems that formalize the relation between the theory of Fredholm's integral equations and the VMF we present here.

  18. EDITORIAL: Focus on Quantum Control

    Science.gov (United States)

    Rabitz, Herschel

    2009-10-01

    Control of quantum phenomena has grown from a dream to a burgeoning field encompassing wide-ranging experimental and theoretical activities. Theoretical research in this area primarily concerns identification of the principles for controlling quantum phenomena, the exploration of new experimental applications and the development of associated operational algorithms to guide such experiments. Recent experiments with adaptive feedback control span many applications including selective excitation, wave packet engineering and control in the presence of complex environments. Practical procedures are also being developed to execute real-time feedback control considering the resultant back action on the quantum system. This focus issue includes papers covering many of the latest advances in the field. Focus on Quantum Control Contents Control of quantum phenomena: past, present and future Constantin Brif, Raj Chakrabarti and Herschel Rabitz Biologically inspired molecular machines driven by light. Optimal control of a unidirectional rotor Guillermo Pérez-Hernández, Adam Pelzer, Leticia González and Tamar Seideman Simulating quantum search algorithm using vibronic states of I2 manipulated by optimally designed gate pulses Yukiyoshi Ohtsuki Efficient coherent control by sequences of pulses of finite duration Götz S Uhrig and Stefano Pasini Control by decoherence: weak field control of an excited state objective Gil Katz, Mark A Ratner and Ronnie Kosloff Multi-qubit compensation sequences Y Tomita, J T Merrill and K R Brown Environment-invariant measure of distance between evolutions of an open quantum system Matthew D Grace, Jason Dominy, Robert L Kosut, Constantin Brif and Herschel Rabitz Simplified quantum process tomography M P A Branderhorst, J Nunn, I A Walmsley and R L Kosut Achieving 'perfect' molecular discrimination via coherent control and stimulated emission Stephen D Clow, Uvo C Holscher and Thomas C Weinacht A convenient method to simulate and visually

  19. Focus Issue on Male Infertility

    Directory of Open Access Journals (Sweden)

    Hideyuki Kobayashi

    2012-01-01

    Full Text Available Male infertility problems can occur when sperms are limited in number or function. In this paper, we describe the clinical evaluation of male infertility. A detailed history, physical examination, and basic semen analysis are required. In addition, ultrasound, karyotyping, and hormonal studies are needed to determine specific causes of infertility. In addition, the World Health Organization (WHO, 2009 has developed a manual to provide guidance in performing a comprehensive semen analysis. Among the possible reasons for male infertility, nonobstructive azoospermia is the least treatable, because few or no mature sperm may be produced. In many cases, men with nonobstructive azoospermia typically have small-volume testes and elevated FSH. Although treatment may not completely restore the quality of semen from men with subnormal fertility, in some cases a successful pregnancy can still be achieved through assisted reproductive technology.

  20. Differences in children's thinking and learning during attentional focus instruction.

    Science.gov (United States)

    Perreault, Melanie E; French, Karen E

    2016-02-01

    Considerable evidence supports the motor learning advantage associated with an external focus of attention; however, very few studies have investigated attentional focus effects with children despite individual functional constraints that have the potential to impact use of instructional content. Thus, the purpose of this study was to determine the effect of attentional focus instruction on motor learning in children. Participants (n=42) aged 9-11years were randomly assigned to one of three gender-stratified groups: (1) control, (2) internal focus, or (3) external focus. Following initial instructions and task demonstration, participants performed 100 modified free throws over two days while receiving additional cues respective to their attentional focus condition and returned approximately 48h later to perform 20 additional free throws. Results revealed no significant learning differences between groups. However, responses to retrospective verbal reports suggest that the use of external focus content during practice may have contributed to some participants' superior performance in retention. Future research should continue to examine attentional focus effects across a variety of ages and incorporate retrospective verbal reports in order to examine children's thoughts during attentional focus instruction.

  1. Focus groups reveal consumer ambivalence.

    Science.gov (United States)

    1983-01-01

    According to qualitative research, Salvadoreans are ambivalent about the use of contraceptives. Since complete responsibility for management of the CSM project was accepted by the Association Demografica Salvadorena (ADS), the agency which operates the contraceptive social marketing project in El Salvador, in November 1980, the need for decisions in such areas as product price increases, introduction of new condom brands, promotion of the vaginal foaming tablet, and assessment of product sales performance had arisen. The ICSMP funded market research, completed during 1983, was intended to provide the data on which such decisions by ADS could be based. The qualitative research involved 8 focus groups, comprised of men and women, aged 18-45, contraceptive users and nonusers, from the middle and lower socioeconomic strata of the city of San Salvador and other suburban areas. In each group a moderator led discussion of family planning and probed respondents for specific attitudes, knowledge, and behavior regarding the use of contraceptives. To assess attitudes at a more emotional level, moderators asked respondents to "draw" their ideas on certain issues. A marked discrepancy was revealed between respondents' intellectual responses to the issues raised in group discussion, as opposed to their feelings expressed in the drawings. Intellectually, participants responded very positively to family planning practice, but when they were asked to draw their perceptions, ambivalent feelings emerged. Drawings of both the user and the nonuser convey primarily negative aspects for either choice. The user is tense and moody toward her children; the nonuser loses her attractiveness and "dies." Figures also show drawings of some of the attitudes of single and married male participants. 1 drawing shows an incomplete and a complete circle, symbolizing a sterilized man (incomplete) and a nonsterilized man (complete). Another picture depicts a chained man who has lost his freedom

  2. Keep the focus on emissions

    Science.gov (United States)

    Clack, C.; Benson, S. M.; Peterson, P.; Long, J. C. S.

    2016-12-01

    Most think that the major battle over climate is between those that want to solve the climate problem and the climate deniers. But there is another conflict, perhaps equally significant between people who all agree climate is a problem but who disagree radically about what they think the solution is. The imperative for stopping further climate change is to stop GHG emissions and the first energy sector of importance is electricity. Every major plan to eliminate emmissions from energy requires a carbon-free electricity system. The most popular idea about how to do this is to use all renewable energy, i.e. solar and wind power. But no one has ever built a large scale 100% renewable energy system and the few examples we have about regions that have tried are not encouraging. As the percentage of renewable energy goes up, ensuring a reliable supply often requires a fossil-based back-up system, so emissions can actually increase. Also, 100% renewable systems rely on massive deployment rates, far beyond any historical precident and often assume that adequate energy storage will "happen" through a combination of currently unavailable technologies. This approach is about adding renewable capacity, not about reducing emissions. Sweden provides a counter example that relies entirely on nuclear power and hydro and has an emission-free, reliable energy system. Likewise, biofuel is often cited as a climate-friendly substitute for petroleum-based fuels. Life-cycle analsyis indicates biofuels are often worse than petroleum-based fuels. We focus efficiency measures on buildings, but efficiency in transportation is even more important because we don't really have the fuel that is carbon neutral. Vehicle efficiency and reductions in vehicle miles traveled does better to address emissions. As mitigation is so important, climate advocates used to think discussion of adaptation was a distraction that should be avoided. But losing track of the need to eliminate emissions is the real

  3. Processing advantages for focused words in Korean

    NARCIS (Netherlands)

    Kember, H.; Choi, J.Y.; Cutler, A.

    2016-01-01

    In Korean, focus is expressed in accentual phrasing. To ascertain whether words focused in this manner enjoy a processing advantage analogous to that conferred by focus as expressed in, e.g, English and Dutch, we devised sentences with target words in one of four conditions: prosodic focus, syntacti

  4. EDITORIAL: Focus on Plasma Medicine

    Science.gov (United States)

    Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

    2009-11-01

    'Plasma Healthcare' is an emerging interdisciplinary research topic of rapidly growing importance, exploring considerable opportunities at the interface of plasma physics, chemistry and engineering with life sciences. Some of the scientific discoveries reported so far have already demonstrated clear benefits for healthcare in areas of medicine, food safety, environmental hygiene, and cosmetics. Examples include ongoing studies of prion inactivation, chronic wound treatment and plasma-mediated cancer therapy. Current research ranges from basic physical processes, plasma chemical design, to the interaction of plasmas with (i) eukaryotic (mammalian) cells; (ii) prokaryotic (bacteria) cells, viruses, spores and fungi; (iii) DNA, lipids, proteins and cell membranes; and (iv) living human, animal and plant tissues in the presence of biofluids. Of diverse interests in this new field is the need for hospital disinfection, in particular with respect to the alarming increase in bacterial resistance to antibiotics, the concomitant needs in private practices, nursing homes etc, the applications in personal hygiene—and the enticing possibility to 'design' plasmas as possible pharmaceutical products, employing ionic as well as molecular agents for medical treatment. The 'delivery' of the reactive plasma agents occurs at the gaseous level, which means that there is no need for a carrier medium and access to the treatment surface is optimal. This focus issue provides a close look at the current state of the art in Plasma Medicine with a number of forefront research articles as well as an introductory review. Focus on Plasma Medicine Contents Application of epifluorescence scanning for monitoring the efficacy of protein removal by RF gas-plasma decontamination Helen C Baxter, Patricia R Richardson, Gaynor A Campbell, Valeri I Kovalev, Robert Maier, James S Barton, Anita C Jones, Greg DeLarge, Mark Casey and Robert L Baxter Inactivation factors of spore-forming bacteria using low

  5. Antipsychotic treatments; Focus on lurasidone

    Directory of Open Access Journals (Sweden)

    Tomiki eSumiyoshi

    2013-08-01

    Full Text Available The introduction of atypical antipsychotic drugs (AAPDs, or second-generation antipsychotics, with clozapine as the prototype, has largely changed the clinicians’ attitudes towards the treatment of mental illnesses including, but not limited to schizophrenia. Initially, there was optimism that AAPDs would be superior over typical antipsychotic drugs (TAPDs, or first-generation antipsychotic drugs, in terms of efficacy for various phenomenological aspects, including cognitive impairment, and less likelihood of causing adverse events. However, these views have been partly challenged by results from recent meta-analysis studies. Specifically, cardio-metabolic side effects of AAPDs, in spite of a relative paucity of extrapyramidal symptoms, may sometimes limit the use of these agents. Accordingly, attempts have been made to develop newer compounds, e.g. lurasidone, with the aim of increasing efficacy and tolerability. Further investigations are warranted to determine if a larger proportion of patients will be benefitted by treatment with AAPDs compared to TAPDs in terms of remission and recovery.

  6. EDITORIAL: Focus on Attosecond Physics

    Science.gov (United States)

    Bandrauk, André D.; Krausz, Ferenc; Starace, Anthony F.

    2008-02-01

    future involve using overdense plasmas. Electronic processes on sub-atomic spatio-temporal scales are the basis of chemical physics, atomic, molecular, and optical physics, materials science, and even some life science processes. Research in these areas using the new attosecond tools will advance together with the ability to control electrons themselves. Indeed, we expect that developments will advance in a way that is similar to advances that have occurred on the femtosecond time scale, in which much previous experimental and theoretical work on the interaction of coherent light sources has led to the development of means for 'coherent control' of nuclear motion in molecules. This focus issue of New Journal of Physics is centered on experimental and theoretical advances in the development of new methodologies and tools for electron control on the attosecond time scale. Topics such as the efficient generation of harmonics; the generation of attosecond pulses, including those having only a few cycles and those produced from overdense plasmas; the description of various nonlinear, nonperturbative laser-matter interactions, including many-electron effects and few-cycle pulse effects; the analysis of ultrashort propagation effects in atomic and molecular media; and the development of inversion methods for electron tomography, as well as many other topics, are addressed in the current focus issue dedicated to the new field of 'Attosecond Physics'. Focus on Attosecond Physics Contents Observing the attosecond dynamics of nuclear wavepackets in molecules by using high harmonic generation in mixed gases Tsuneto Kanai, Eiji J Takahashi, Yasuo Nabekawa and Katsumi Midorikawa Core-polarization effects in molecular high harmonic generation G Jordan and A Scrinzi Interferometric autocorrelation of an attosecond pulse train calculated using feasible formulae Y Nabekawa and K Midorikawa Attosecond pulse generation from aligned molecules—dynamics and propagation in H2+ E Lorin, S

  7. Determination of Toxaphenes in Soil by High-Resolution Double-Focusing Magnetic MS Combined with Isotope Dilution and GC%同位素稀释-气相色谱-高分辨双聚焦磁质谱法测定土壤中毒杀芬的含量

    Institute of Scientific and Technical Information of China (English)

    王荟; 高占; 章勇; 胡冠九

    2016-01-01

    提出了同位素稀释-气相色谱-高分辨质谱法测定土壤样品中3种指示性毒杀芬Parlar26(P26)、Parlar50(P50)和 Parlar62(P62)。以二氯甲烷-丙酮(1+1)混合液为提取溶剂对土壤样品进行微波萃取,提取液经活化硅胶柱净化分离,洗脱液经氮气吹扫浓缩至100μL 后,以13 C12-PCB153为同位素内标,在 DB-5MS 色谱柱上分离,质谱中采用电子轰击离子源。P26、P50和P62的检出限(3.143S)分别为1,3,5 pg,测定值的相对标准偏差(n=5)小于6%。方法用于某地区表层土壤中3种指示性毒杀芬的检测,测得 P26,P50,P62的含量分别为0.08,0.04,0.03 ng· g-1。%A novel method for the determination of 3 indicative toxaphenes comprised of Parlar26 (P26), Parlar50 (P50)and Parlar62 (P62)in soil was proposed,based on high-resolution double-focusing magnetic MS combined with isotope dilution and GC.The sample was treated by microwave assisted extraction with a mixture (1+1)of dichloromethane and acetone as solvent.The extract was then purified on an activated silica gel column. The eluate was concentrated to 100 μL by N2-blowing,13 C12-PCB153 was added as internal standard,and the solution was separated on a DB-5MS column.EI was adopted in MS.The detection limits (3.143S)of P26,P50 and P62 were 1,3,5 pg,respectively.RSDs (n=5)were all less than 6%.The method was used to determine P26,P50 and P62 in a top soil sample,giving results of 0.08,0.04 ,0.03 ng·g-1 ,respectively.

  8. Dark Matter Detection in Focus Point Supersymmetry

    CERN Document Server

    Draper, Patrick; Kant, Philipp; Profumo, Stefano; Sanford, David

    2013-01-01

    We determine the prospects for direct and indirect detection of thermal relic neutralinos in supersymmetric theories with multi-TeV squarks and sleptons. We consider the concrete example of the focus point region of minimal supergravity, but our results are generically valid for all models with decoupled scalars and mixed Bino-Higgsino or Higgsino-like dark matter. We determine the parameter space consistent with a 125 GeV Higgs boson including 3-loop corrections in the calculation of the Higgs mass. These corrections increase $m_h$ by 1--3 GeV, lowering the preferred scalar mass scale and decreasing the fine-tuning measure in these scenarios. We then systematically examine prospects for dark matter direct and indirect detection. Direct detection constraints do not exclude these models, especially for $\\mu < 0$. At the same time, the scenario generically predicts spin-independent signals just beyond current bounds. We also consider indirect detection with neutrinos, gamma rays, anti-protons, and anti-deute...

  9. EDITORIAL: Focus on Gravitational Lensing

    Science.gov (United States)

    Jain, Bhuvnesh

    2007-11-01

    Gravitational lensing emerged as an observational field following the 1979 discovery of a doubly imaged quasar lensed by a foreground galaxy. In the 1980s and '90s dozens of other multiply imaged systems were observed, as well as time delay measurements, weak and strong lensing by galaxies and galaxy clusters, and the discovery of microlensing in our galaxy. The rapid pace of advances has continued into the new century. Lensing is currently one of best techniques for finding and mapping dark matter over a wide range of scales, and also addresses broader cosmological questions such as understanding the nature of dark energy. This focus issue of New Journal of Physics presents a snapshot of current research in some of the exciting areas of lensing. It provides an occasion to look back at the advances of the last decade and ahead to the potential of the coming years. Just about a decade ago, microlensing was discovered through the magnification of stars in our galaxy by invisible objects with masses between that of Jupiter and a tenth the mass of the Sun. Thus a new component of the mass of our galaxy, dubbed MACHOs, was established (though a diffuse, cold dark matter-like component is still needed to make up most of the galaxy mass). More recently, microlensing led to another exciting discovery—of extra-solar planets with masses ranging from about five times that of Earth to that of Neptune. We can expect many more planets to be discovered through ongoing surveys. Microlensing is the best technique for finding Earth mass planets, though it is not as productive overall as other methods and does not allow for follow up observations. Beyond planet hunting, microlensing has enabled us to observe previously inaccessible systems, ranging from the surfaces of other stars to the accretion disks around the black holes powering distant quasars. Galaxies and galaxy clusters at cosmological distances can produce dramatic lensing effects: multiple images of background galaxies

  10. Intracranial treatment envelope mapping of transcranial focused ultrasound

    Science.gov (United States)

    Eames, Matthew D. C.; Hananel, Arik; Kassell, Neal F.; Snell, John W.

    2012-11-01

    Presented here are the results of a volumetric, thermal treatment envelope map for transcranial focused ultrasound. The aim was to determine the treatable volume of the intracranial cavity in order to identify potential clinical applications and direct future research efforts. It was determined that thalamic targets are optimal for both transcranical MRg-FUS systems used in this work, which operate at 220 kHz and 650 kHz, respectively. It is hoped that future research efforts will focus on expanding these treatment envelopes in order to expand the possible neurosurgical applications for this technology.

  11. Using Focus Groups to Validate a Pharmacy Vaccination Training Program

    Directory of Open Access Journals (Sweden)

    Mary Bushell

    2015-06-01

    Full Text Available Introduction: Focus group methodology is commonly used to quickly collate, integrated views from a variety of different stakeholders. This paper provides an example of how focus groups can be employed to collate expert opinion informing amendments on a newly developed training program for integration into undergraduate pharmacy curricula. Materials and methods: Four focus groups were conducted, across three continents, to determine the appropriateness and reliability of a developed vaccination training program with nested injection skills training. All focus groups were comprised of legitimate experts in the field of vaccination, medicine and/or pharmacy. Results: Themes that emerged across focus groups informed amendments giving rise to a validated version of a training program. Discussion: The rigorous validation of the vaccination training program offers generalizable lessons to inform the design and validation of future training programs intended for the health sector and or pharmacy curricula. Using the knowledge and experience of focus group participants fostered collaborative problem solving and validation of material and concept development. The group dynamics of a focus group allowed synthesis of feedback in an inter-professional manner. Conclusions: This paper provides a demonstration of how focus groups can be structured and used by health researchers to validate a newly developed training program.

  12. Possibilities for focusing ultrasonic fields - A survey

    Science.gov (United States)

    Schlengermann, U.

    1986-05-01

    Focusing techniques for ultrasound devices used in NDE are examined in a review of recent experimental investigations and application reports. The advantages of focused sound fields are outlined (including increased sensitivity, lateral resolution, and S/N and improved reflector scanning); the characteristics of the focused field are reviewed; the fundamental principles of curved-crystal, lens, curved-reflector, zone-plate, and phase-plate focusing are explained; and their practical adaptation in NDE problems (by changing delay path, changing lenses, or switching annular arrays) is described. Consideration is given to geometric and technical limitations on focusing applicability and to the optimization of focusing. Diagrams and drawings are provided.

  13. Focus takes time: structural effects on reading.

    Science.gov (United States)

    Lowder, Matthew W; Gordon, Peter C

    2015-12-01

    Previous eye-tracking work has yielded inconsistent evidence regarding whether readers spend more or less time encoding focused information compared with information that is not focused. We report the results of an eye-tracking experiment that used syntactic structure to manipulate whether a target word was linguistically defocused, neutral, or focused, while controlling for possible oculomotor differences across conditions. As the structure of the sentence made the target word increasingly more focused, reading times systematically increased. We propose that the longer reading times for linguistically focused words reflect deeper encoding, which explains previous findings showing that readers have better subsequent memory for focused versus defocused information.

  14. Focus on Communication: NIH Research to Results

    Science.gov (United States)

    ... Current Issue Past Issues Special Section: Focus on Communication NIH Research to Results Past Issues / Fall 2008 ... grew new hair cells. Read More "Focus on Communication" Articles Living with Hearing Loss / Anatomy of the ...

  15. Analysis and modeling of "focus" in context

    DEFF Research Database (Denmark)

    Hovy, Dirk; Anumanchipalli, Gopala; Parlikar, Alok

    2013-01-01

    This paper uses a crowd-sourced definition of a speech phenomenon we have called focus. Given sentences, text and speech, in isolation and in context, we asked annotators to identify what we term the focus word. We present their consistency in identifying the focused word, when presented with text...

  16. Collective action : a regulatory focus perspective

    NARCIS (Netherlands)

    Zaal, Maarten Pieter

    2012-01-01

    In this dissertation I investigate how individuals respond to collective disadvantage from the perspective of regulatory focus theory. Regulatory focus theory distinguishes between two motivational systems: promotion focus, the system in charge of the approach of positive end-states, and prevention

  17. Techniques For Focusing In Zone Electrophoresis

    Science.gov (United States)

    Sharnez, Rizwan; Twitty, Garland E.; Sammons, David W.

    1994-01-01

    In two techniques for focusing in zone electrophoresis, force of applied electrical field in each charged particle balanced by restoring force of electro-osmosis. Two techniques: velocity-gradient focusing (VGF), suitable for rectangular electrophoresis chambers; and field-gradient focusing (FGF), suitable for step-shaped electrophoresis chambers.

  18. Increased jump height with an external focus due to enhanced lower extremity joint kinetics.

    Science.gov (United States)

    Wulf, Gabriele; Dufek, Janet S

    2009-10-01

    Individuals jump higher when they adopt an external focus of attention, relative to an internal focus or no focus of attention (G. Wulf, T. Zachry, C. Granados, & J. S. Dufek, 2007). In the present study, the authors determined the underlying cause of this effect. Participants performed a vertical jump-and-reach task for (a) an external focus condition (i.e., participants focused on the rungs of a Vertec [Perform Better, Cranston, RI] measurement device that they touched) and (b) an internal focus condition (i.e., participants focused on the finger with which they touched the rungs). Participants' jump height, center-of-mass displacement, jump impulse, and lower extremity joint moments were greater with an external focus compared with an internal focus. These results suggest that participants jump higher by producing greater forces when they adopt an external focus. This finding adds to evidence that an external focus facilitates the production of effective and efficient movement patterns.

  19. Optimal focusing of a beam in a ring vortex

    Science.gov (United States)

    Arrizón, Victor; Ruiz, Ulises; Aguirre-Olivas, Dilia; Mellado-Villaseñor, Gabriel

    2015-12-01

    Conventional light focusing, i.e. concentration of an extended optical field within a small area around a point, is a frequently used process in Optics. An important extension to conventional focusing is the generation of the annular focal field of an optical beam. We discuss a simple optical setup that achieves this kind of focusing employing a phase plate as unique optical component. It is assumed that the annular focal field is modulated by an azimuthal phase of integer order q that converts the field in a ring vortex. We first establish the class of beams that being transmitted through the phase plate can be focused into a ring vortex. Then, for each beam in this class we determine the plate transmittance that generates the vortex with the maximum possible intensity, which is referred to as optimal ring vortex.

  20. Optimal ultrasonic array focusing in attenuative media.

    Science.gov (United States)

    Ganguli, A; Gao, R X; Liang, K; Jundt, J

    2011-12-01

    This paper presents a parametric study on the efficiency of ultrasound focusing in an attenuative medium, using phased arrays. Specifically, an analytical model of ultrasound wave focusing in a homogeneous, isotropic and attenuative fluid with point sources is presented. Calculations based on the model have shown that in an attenuative medium, an optimum frequency exists for the best focusing performance for a particular size of aperture and focal distance. The effect of different f numbers on the focusing performance in the attenuative medium is further investigated. The information obtained from the analytical model provides insights into the design and installation of a phased transducer array for energy efficient wave focusing.

  1. Synthetic focusing in ultrasound modulated tomography

    KAUST Repository

    Kuchment, Peter

    2010-09-01

    Several hybrid tomographic methods utilizing ultrasound modulation have been introduced lately. Success of these methods hinges on the feasibility of focusing ultrasound waves at an arbitrary point of interest. Such focusing, however, is difficult to achieve in practice. We thus propose a way to avoid the use of focused waves through what we call synthetic focusing, i.e. by reconstructing the would-be response to the focused modulation from the measurements corresponding to realistic unfocused waves. Examples of reconstructions from simulated data are provided. This non-technical paper describes only the general concept, while technical details will appear elsewhere. © 2010 American Institute of Mathematical Sciences.

  2. Teaching focus in psychotherapy: a training essential.

    Science.gov (United States)

    Summers, Richard F; Xuan, Yan; Tavakoli, Donald N

    2013-03-01

    Practical application of psychodynamic therapy technique requires that the therapist focus the treatment. The authors review the current evidence about focus in psychotherapy, which suggests that it has a beneficial impact on outcome and patient satisfaction. The core psychodynamic problem is proposed as a valuable conceptual model for providing focus for patient, psychotherapist, and supervisor. The authors narrate a case history from the perspective of both the psychotherapist and the supervisor to demonstrate the opportunities and challenges in using this concept. Finally, the authors suggest that a focus on focus is desirable in residency psychotherapy training programs, and they make suggestions for educational methods that enhance resident training in this area.

  3. Acoustic focusing by metal circular ring structure

    Science.gov (United States)

    Xia, Jian-Ping; Sun, Hong-Xiang

    2015-02-01

    We report an exotic acoustic focusing effect through a simple brass circular ring structure immersed in water. The acoustic waves can be focused on a prefect point at the centre of the ring structure. This exotic acoustic focusing phenomenon arises from the intrinsic modes in the ring structure at some special eigenfrequencies, which is essentially distinct from the previous studies originating from the negative refraction. The focusing effect is closely related to the size and shape of the ring structure. Interesting applications of the focusing mechanism in black box detectors in the sea and medical ultrasound treatment are further discussed.

  4. Ventilatory strategy in ARDS focusing on pressure controlled ventilation

    NARCIS (Netherlands)

    J. Kesecioglu (Jozef)

    1994-01-01

    textabstractThis thesis focuses on comparison of different modes of ventilation in animals and patients with ARDS. The aim is to determine the immediate advantages of one mode over the other in terms of gas exchange, airway pressures,' hemodynamics and ventilation inhomogeneity.

  5. Children's Problems with Focus and Cohesion in Revising.

    Science.gov (United States)

    Champagne, Mireille; And Others

    A study was conducted to determine whether children in revising their writing to accommodate new information would make corresponding textual changes to preserve appropriate focus and cohesion. The subjects, 48 children each from grades three, six, and nine, were presented with a task that involved descriptions of pictures with incongruent…

  6. Research Timeline: Form-Focused Instruction and Second Language Acquisition

    Science.gov (United States)

    Nassaji, Hossein

    2016-01-01

    This article provides a timeline of research on form-focused instruction (FFI). Over the past 40 years, research on the role of instruction has undergone many changes. Much of the early research concentrated on determining whether formal instruction makes any difference in the development of learner language. This question was motivated in part by…

  7. Research Timeline: Form-Focused Instruction and Second Language Acquisition

    Science.gov (United States)

    Nassaji, Hossein

    2016-01-01

    This article provides a timeline of research on form-focused instruction (FFI). Over the past 40 years, research on the role of instruction has undergone many changes. Much of the early research concentrated on determining whether formal instruction makes any difference in the development of learner language. This question was motivated in part by…

  8. Fast calculation of the best focus position

    Science.gov (United States)

    Bezzubik, Vitalii; Belashenkov, Nikolai; Vdovin, Gleb

    2015-03-01

    New computational technique based on linear-scale differential analysis (LSDA) of digital image is proposed to find the best focus position in digital microscopy by means of defocus estimation in two near-focal positions only. The method is based on the calculation of local gradients of the image on different scales using its convolution with a number of differential filters of linearly varying sizes, consequent removal of noisy pixels out of consideration, and selection of pixels at the edges of objects. It is shown that the mean values of the selected gradients decrease while the scale increases thus the rate of change of these mean values of gradients unambiguously determines the magnitude of digital image defocus as a function of scale. Using this method the value and sign of defocus can be found if the result of LSDA of captured images is compared with pre-defined look-up table. The robustness of the proposed method to spatial noise is achieved by ignoring pixels that are corrupted by spatial noise within the areas of the image outside the edges of objects. Most computational operations of the method are based on integer arithmetic that simplifies its practical implementation and significantly improves the performance. The latter aspect is particularly important for practical use in real-time imaging systems.

  9. Focusing and Polarization in Intuitionistic Logic

    CERN Document Server

    Liang, Chuck

    2007-01-01

    A focused proof system provides a normal form to cut-free proofs that structures the application of invertible and non-invertible inference rules. The focused proof system of Andreoli for linear logic has been applied to both the proof search and the proof normalization approaches to computation. Various proof systems in literature exhibit characteristics of focusing to one degree or another. We present a new, focused proof system for intuitionistic logic, called LJF, and show how other proof systems can be mapped into the new system by inserting logical connectives that prematurely stop focusing. We also use LJF to design a focused proof system for classical logic. Our approach to the design and analysis of these systems is based on the completeness of focusing in linear logic and on the notion of polarity that appears in Girard's LC and LU proof systems.

  10. Radiation Reaction in a Bent Focusing System

    Science.gov (United States)

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.

    1996-05-01

    We have shown that in a straight, continuous focusing channel the radiation reaction is different from that in a bending magnet. Quantum excitation to the transverse action is absent in this focusing system, and the radiation damping is faster in the transverse direction than in the longitudinal one. In this talk we study the effect of radiation in a combined-function system, where both focusing and bending fields are present. In one case where the bending dominates over the focusing, we recover the result of standard synchrotron radiation damping in storage rings. In the other case where the focusing dominates over the bending, we find that the lack of quantum excitation and the asymmetric damping found in a straight focusing channel still hold. In addition, the possibility of designing a focusing-dominated damping ring to demonstrate and apply this effect is discussed.

  11. Brain Death Determination.

    Science.gov (United States)

    Spinello, Irene M

    2015-09-01

    In the United States, each year 1% to 2% of deaths are brain deaths. Considerable variation in the practice of determining brain death still remains, despite the publication of practice parameters in 1995 and an evidence-based guideline update in 2010. This review is intended to give bedside clinicians an overview of definition, the causes and pitfalls of misdiagnosing brain death, and a focus on the specifics of the brain death determination process.

  12. Needs of Non Energy-Focused Contractors

    Energy Technology Data Exchange (ETDEWEB)

    Liaukus, C.

    2012-12-01

    To better understand the informational needs of non energy-focused contractors, including what information they need to motivate them to become energy-focused, the BARA team studied the type of information provided by the national programs, trade associations, and manufacturers that were researched for the related technical report: Effective Communication of Energy Efficiency. While that report focused on the delivery method, format, and strategy of the information, this study examines the content being put forward.

  13. Partial focusing by indefinite complementary metamaterials

    Science.gov (United States)

    Cheng, Qiang; Liu, Ruopeng; Mock, Jack J.; Cui, Tie Jun; Smith, David R.

    2008-09-01

    We have experimentally realized a two-dimensional partial focusing within a planar waveguide using complementary indefinite metamaterials. When the electric fields emitted from the dipole are TE polarized, the focusing condition requires negative magnetic response in the propagation direction of the waveguide, which can be achieved by the complementary electric resonator (CELC) structures. We have carefully designed the experimental configurations and the dimensions for the CELC structures. The experimental result is consistent with the theoretical prediction, which validates the partial focusing phenomenon.

  14. Needs of Non-Energy Focused Contractors

    Energy Technology Data Exchange (ETDEWEB)

    Liakus, C. [Building Media and the Building America Retrofit Alliance (BARA), Wilmington, DE (United States)

    2012-12-01

    To better understand the informational needs of non-energy focused contractors, including what information they need to motivate them to become energy-focused, the BARA team studied the type of information provided by the national programs, trade associations, and manufacturers that were researched for the related technical report: Effective Communication of Energy Efficiency. While that report focused on the delivery method, format, and strategy of the information, this study examines the content being put forward.

  15. The Use of Online Focus Groups to Design an Online Food Safety Education Intervention

    Science.gov (United States)

    Mayer, Ashley Bramlett; Harrison, Judy A.

    2012-01-01

    In the development of an online food safety education intervention for college students, online focus groups were used to determine the appropriate format and messages. Focus groups are often used in qualitative research and formative evaluation of public health programs, yet traditional focus groups can be both difficult and expensive to…

  16. Regulatory focus affects physician risk tolerance.

    Science.gov (United States)

    Veazie, Peter J; McIntosh, Scott; Chapman, Benjamin P; Dolan, James G

    2014-01-01

    Risk tolerance is a source of variation in physician decision-making. This variation, if independent of clinical concerns, can result in mistaken utilization of health services. To address such problems, it will be helpful to identify nonclinical factors of risk tolerance, particularly those amendable to intervention-regulatory focus theory suggests such a factor. This study tested whether regulatory focus affects risk tolerance among primary care physicians. Twenty-seven primary care physicians were assigned to promotion-focused or prevention-focused manipulations and compared on the Risk Taking Attitudes in Medical Decision Making scale using a randomization test. Results provide evidence that physicians assigned to the promotion-focus manipulation adopted an attitude of greater risk tolerance than the physicians assigned to the prevention-focused manipulation (p = 0.01). The Cohen's d statistic was conventionally large at 0.92. Results imply that situational regulatory focus in primary care physicians affects risk tolerance and may thereby be a nonclinical source of practice variation. Results also provide marginal evidence that chronic regulatory focus is associated with risk tolerance (p = 0.05), but the mechanism remains unclear. Research and intervention targeting physician risk tolerance may benefit by considering situational regulatory focus as an explanatory factor.

  17. Low voltage operation of plasma focus.

    Science.gov (United States)

    Shukla, Rohit; Sharma, S K; Banerjee, P; Das, R; Deb, P; Prabahar, T; Das, B K; Adhikary, B; Shyam, A

    2010-08-01

    Plasma foci of compact sizes and operating with low energies (from tens of joules to few hundred joules) have found application in recent years and have attracted plasma-physics scientists and engineers for research in this direction. We are presenting a low energy and miniature plasma focus which operates from a capacitor bank of 8.4 muF capacity, charged at 4.2-4.3 kV and delivering approximately 52 kA peak current at approximately 60 nH calculated circuit inductance. The total circuit inductance includes the plasma focus inductance. The reported plasma focus operates at the lowest voltage among all reported plasma foci so far. Moreover the cost of capacitor bank used for plasma focus is nearly 20 U.S. dollars making it very cheap. At low voltage operation of plasma focus, the initial breakdown mechanism becomes important for operation of plasma focus. The quartz glass tube is used as insulator and breakdown initiation is done on its surface. The total energy of the plasma focus is approximately 75 J. The plasma focus system is made compact and the switching of capacitor bank energy is done by manual operating switch. The focus is operated with hydrogen and deuterium filled at 1-2 mbar.

  18. Automatic focusing system of BSST in Antarctic

    Science.gov (United States)

    Tang, Peng-Yi; Liu, Jia-Jing; Zhang, Guang-yu; Wang, Jian

    2015-10-01

    Automatic focusing (AF) technology plays an important role in modern astronomical telescopes. Based on the focusing requirement of BSST (Bright Star Survey Telescope) in Antarctic, an AF system is set up. In this design, functions in OpenCV is used to find stars, the algorithm of area, HFD or FWHM are used to degree the focus metric by choosing. Curve fitting method is used to find focus position as the method of camera moving. All these design are suitable for unattended small telescope.

  19. FEMP Focus: 2011 Volume 20 Issue 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-04-05

    Department of Energy (DOE); Federal Energy Management Program; FEMP Focus Newsletter; December 2010; Alternative Financing, Guidance Documents, Recovery Act Technical Assistance, Training, Energy Awareness

  20. Status of the STIS Instrument Focus

    Science.gov (United States)

    Proffitt, Charles R.; Monroe, TalaWanda; Dressel, Linda

    2017-01-01

    The Space Telescope Imaging Spectrograph needs to bring images to a good focus at its aperture plane and three detectors, for each of several optical paths. We discuss various ways of measuring the evolution of the focus over time for both the aperture plane and for a variety of imaging and spectroscopic modes. Evidence suggests that between 2013 and 2015 the best focus of STIS relative to the HST best focus, based on WFC3/UVIS and ACS/WFC monitoring, shifted by the equivalent of 3 microns of HST secondary motion, resulting in a decrease in the average small aperture throughput. We discuss the implications of this change for STIS observations.

  1. Analyzing the Focus Sensor Images for ODI at WIYN

    Science.gov (United States)

    Nowicki, Robert P.

    2006-12-01

    The WIYN (Wisconsin, Indiana, Yale, & NOAO) is building the One Degree Imager (ODI) for its 3.5m telescope at Kitt Peak. ODI is a wide field imager that is focusing on delivering the excellent image quality of the WIYN telescope. Maintaining good telescope focus is essential for the success of this instrument. A proposed technique for focusing ODI is using a CCD sensor that is tilted with respect to the instrument’s focal plane. We numerically analyzed images obtained with a prototype focus camera using several methods to determine the location of the best-focused stars. Specifically, a least chi-squares fit was used to fit a second order polynomial to the plot of FWHM versus pixel position along the CCD for the stars taken in these focus sensor images. Once ODI is operational at WIYN, one can use this algorithm to find the best FWHM and its position along the CCD, and feed this information back to the telescope control system. These numerical methods were implemented in the scripting language tcl/tk because of its easily built user interfaces and ready acceptance at Kitt Peak Observatory. R.P.N.'s research was supported by the NOAO/KPNO Research Experiences for Undergraduates (REU) Program which is funded by the National Science Foundation through Scientific Program Order No. 3 (AST-0243875) of the Cooperative Agreement No. AST-0132798 between the Association of Universities for Research in Astronomy (AURA) and the NSF.

  2. Field analysis of two-dimensional focusing grating couplers

    Science.gov (United States)

    Borsboom, P.-P.; Frankena, H. J.

    1995-05-01

    A different technique was developed by which several two-dimensional dielectric optical gratings, consisting 100 or more corrugations, were treated in a numerical reliable approach. The numerical examples that were presented were restricted to gratings made up of sequences of waveguide sections symmetric about the x = 0 plane. The newly developed method was effectively used to investigate the field produced by a two-dimensional focusing grating coupler. Focal-region fields were determined for three symmetrical gratings with 19, 50, and 124 corrugations. For focusing grating coupler with limited length, high-frequency intensity variations were noted in the focal region.

  3. Design for the environment - do we get the focus right?

    DEFF Research Database (Denmark)

    Hauschild, Michael Zwicky; Jeswiet, Jack; Alting, Leo

    2004-01-01

    is the function provided and what is the optimal way of providing it while making a business out of it? Which product should the company then produce? 2. Where are the “environmental hot spots” in the life cycle of this product? 3. Which DFE tool supports optimisation of the product by reducing these hot spots?......Sometimes, products resulting from design for environment (DFE) endeavours are sub-optimisations from an environmental perspective, because the tool determines the process and not vice versa. For a more systematic way of getting the focus right, a hierarchy of focusing is introduced: 1. What...

  4. Dispersion in a bent-solenoid channel with symmetric focusing

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chun-xi [Argonne National Lab. (ANL), Argonne, IL (United States)

    2001-08-21

    Longitudinal ionization cooling of a muon beam is essential for muon colliders and will be useful for neutrino factories. Bent-solenoid channels with symmetric focusing has been considered for beam focusing and for generating the required dispersion in the ``emittance exchange'' scheme of longitudinal cooling. In this paper, we derive the Hamiltonian that governs the linear beam dynamics of a bent-solenoid channel, solve the single-particle dynamics, and give equations for determining the lattice functions, in particular, the dispersion functions.

  5. 3D Printed Terahertz Focusing Grating Couplers

    Science.gov (United States)

    Jahn, David; Weidenbach, Marcel; Lehr, Jannik; Becker, Leonard; Beltrán-Mejía, Felipe; Busch, Stefan F.; Balzer, Jan C.; Koch, Martin

    2017-02-01

    We have designed, constructed and characterized a grating that focuses electromagnetic radiation at specific frequencies out of a dielectric waveguide. A simple theoretical model predicts the focusing behaviour of these chirped gratings, along with numerical results that support our assumptions and improved the grating geometry. The leaky waveguide was 3D printed and characterized at 120 GHz demonstrating its potential for manipulating terahertz waves.

  6. Law-Focused Education: A Statewide Program

    Science.gov (United States)

    Black, Watt L.

    1977-01-01

    Law Focused Education, Inc., a Texas nonprofit educational organization, has developed innovative programs designed (1) to promote law-related education among inservice social studies teachers and (2) to promote the incorporation of law-focused concepts into the graduate and undergraduate curriculum of those institutions with teacher education…

  7. Identifying Information Focuses in Listening Comprehension

    Science.gov (United States)

    Zhang, Hong-yan

    2011-01-01

    The study explains the process of learners' listening comprehension within Halliday's information theory in functional grammar, including the skills of identifying focuses while listening in college English teaching. Identifying information focuses in listening is proved to improve the students' communicative listening ability by the means of a…

  8. Attentional Focus Effects in Balance Acrobats

    Science.gov (United States)

    Wulf, Gabriele

    2008-01-01

    Performing and learning motor skills has been shown to be enhanced if the performer adopts an external relative to internal focus (or no focus) of attention (Wulf, 2007). The present study examined the generalizability of this effect to top-level performers (balance acrobats). Participants performed a balance task (standing on an inflated rubber…

  9. High-intensity, focused ultrasonic fields

    DEFF Research Database (Denmark)

    Jensen, Leif Bjørnø

    1988-01-01

    distribution, etc. involving nonlinearity, diffraction, and absorption in the high-intensity focused ultrasonic fields produced by an ellipsoid as well as a spherical cap focusing geometry. Data from the development of an ESWL of the piezoelectric disk type are reported including demands to transducers...

  10. Conducting the Computer-Mediated Focus Group.

    Science.gov (United States)

    Saban, Kenneth A.

    The growing popularity of focus group measurements can be traced to any one of four factors: (1) the economics associated with focus groups; (2) the speed at which data can now be collected; (3) the need to understand customer motivations; and (4) the desire to improve subsequent qualitative research activities and programs. Market researchers are…

  11. Inclusive Focus Particles in English and Korean

    Science.gov (United States)

    Kang, Sang-gu

    2011-01-01

    When discussing focus particles, it has been common practice to rely on the dichotomy of inclusive vs. exclusive particles, "a la" Konig (1991). Inclusive focus particles are often further divided into scalar particles, such as "also", "too", and "either", and non-scalar particles, such as "even". In this thesis, I advance a comparative analysis…

  12. From focus to context and back

    DEFF Research Database (Denmark)

    Weigel, Martin; Boring, Sebastian; Marquardt, Nicolai

    Focus plus context displays combine high-resolution detail and lower-resolution overview using displays of different pixel densities. Historically, they employed two fixed-size displays of different resolutions, one embedded within the other. In this paper, we explore focus plus context displays ...

  13. Attentional Focusing Instructions and Force Production

    Directory of Open Access Journals (Sweden)

    David C Marchant

    2011-01-01

    Full Text Available Research progress assessing the role of attentional focusing instructions on skill acquisition and performance has lead researchers to apply this approach to force production tasks. Initial converging evidence indicates that force production tasks are sensitive to verbal instruction; externally focused instructions (onto movement outcomes, or onto the object force is being exerted against are shown to be more beneficial than internally focused instructions (focusing attention onto the movements being executed. These benefits are observed for maximal and accurate force production, as well as the maintenance of force production in prolonged tasks. A range of mechanisms are identified supporting the proposal that an external focus promotes movement efficiency in line with energy and effort conservation. Future research is required to assess how this developing body of work interacts with the broader understanding of psychological and physiological factors implicated in the effective production, maintenance and limitation of maximal or sub-maximal forces.

  14. Focusing criterion in DHM image reconstruction

    Science.gov (United States)

    Mihailescu, M.; Mihale, N.; Popescu, R. C.; Acasandrei, A.; Paun, I. A.; Dinescu, M.; Scarlat, E.

    2015-02-01

    This study is presenting the theoretical approach and the practical results of a precise activity involved in the hologram reconstruction in order to find the optimally focused image of MG63 osteoblast-like cells cultivated on polymeric flat substrates. The morphology and dynamic of the cell is investigated by digital holographic microscopy (DHM) technique. The reconstruction is digitally performed using an algorithm based on the scalar theory of diffraction in the Fresnel approximation. The quality of the 3D images of the cells is crucially depending on the focusing capability of the reconstruction chain to fit the parameters of the optical recorder, particularly the focusing value. Our proposal to find the focused image is based on the images decomposition on gray levels and their histogram analysis. More precisely the focusing criterion is based on the evaluation of the form of this distribution.

  15. Happy mood decreases self-focused attention.

    Science.gov (United States)

    Green, Jeffrey D; Sedikides, Constantine; Saltzberg, Judith A; Wood, Joanne V; Forzano, Lori-Ann B

    2003-03-01

    Research addressing the influence of happy mood on self-focused attention has yielded inconsistent results. Some studies found that happy mood decreased self-focus relative to sad mood. Other studies did not detect a significant difference between happy and neutral mood, and still other studies found that happy mood, relative to neutral mood, increased self-focus. These investigations have potential shortcomings, such as an insufficiently powerful happy mood induction and a confound between visualization mood inductions and self-focus itself. The present experiment addressed these shortcomings by inducing mood via musical selections, equalizing the approximate potency between happy and sad moods, and using a within-participants design. Relative to neutral mood, happy mood decreased self-focused attention.

  16. Final focus systems for linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, R.A.

    1987-11-01

    The final focus system of a linear collider must perform two primary functions, it must focus the two opposing beams so that their transverse dimensions at the interaction point are small enough to yield acceptable luminosity, and it must steer the beams together to maintain collisions. In addition, the final focus system must transport the outgoing beams to a location where they can be recycled or safely dumped. Elementary optical considerations for linear collider final focus systems are discussed, followed by chromatic aberrations. The design of the final focus system of the SLAC Linear Collider (SLC) is described. Tuning and diagnostics and steering to collision are discussed. Most of the examples illustrating the concepts covered are drawn from the SLC, but the principles and conclusions are said to be generally applicable to other linear collider designs as well. 26 refs., 17 figs. (LEW)

  17. Fermion Determinants

    OpenAIRE

    Fry, M. P.

    2001-01-01

    The current status of bounds on and limits of fermion determinants in two, three and four dimensions in QED and QCD is reviewed. A new lower bound on the two-dimensional QED determinant is derived. An outline of the demonstration of the continuity of this determinant at zero mass when the background magnetic field flux is zero is also given.

  18. Digital ultrasonically encoded (DUE) optical focusing into random media

    CERN Document Server

    Tay, Jian Wei; Suzuki, Yuta; Wang, Lihong V

    2013-01-01

    Focusing light into opaque random or scattering media such as biological tissue is a much sought-after goal for biomedical applications such as photodynamic therapy, optical manipulation, and photostimulation. However, focusing with conventional lenses is restricted to one transport mean free path in scattering media, limiting both optical penetration depth and resolution. Focusing deeper is possible by using optical phase conjugation or wavefront shaping to compensate for the scattering. For practical applications, wavefront shaping offers the advantage of a robust optical system that is less sensitive to optical misalignment. Here, the phase of the incident light is spatially tailored using a phase-shifting array to pre-compensate for scattering. The challenge, then, is to determine the phase pattern which allows light to be optimally delivered to the target region. Optimization algorithms are typically employed for this purpose, with visible particles used as targets to generate feedback. However, using th...

  19. Colorectal cancer screening brochure for Latinos: focus group evaluation.

    Science.gov (United States)

    Cooperman, Julia L; Efuni, Elizaveta; Villagra, Cristina; DuHamel, Katherine; Jandorf, Lina

    2013-09-01

    Colorectal cancer (CRC) can be effectively prevented via screening colonoscopy, yet adherence rates remain low among Latinos. Interventions targeting individual and cultural barriers to screening are needed. We developed an educational brochure to target these barriers faced by a diverse Latino population. The objective was to evaluate the responses of the target population to the culturally and theoretically informed brochure through community member focus groups. Facilitators conducted six focus groups, stratified by gender, language, and prior colonoscopy experience. Topics included: brochure content and layout, cancer knowledge, and CRC screening determinants. Focus groups documented community members' responses to the brochure's overall message and its informational and visual components. Changes to wording, visual aids, and content were suggested to make the brochure culturally more acceptable. Results indicated relevance of the theoretically and culturally guided approach to the development of the brochure leading to refinement of its content and design.

  20. Design and tests of an adaptive focusing neutron guide

    Energy Technology Data Exchange (ETDEWEB)

    Valicu, Roxana Georgiana

    2012-08-23

    This work contains the Monte Carlo Simulations, as well as the first tests with an adaptive focusing neutron guide for creating a focus that does not depend on the wavelength of the incoming neutrons. All known neutron guides consist of a rectangular shape, built out of four glass plates. The inner side of the guide is coated with a complex structure of metal layers. This reflects and guides the neutrons (in analogy with the reflection of the light). For beam focusing neutron guides with fixed curvature can be built. For most experiments it is important that the beam is focused on to a small surface of the sample. In the case of focusing guides with fixed curvature it has been observed that the focusing (dimension and position of the beam focus) is wavelength dependent. This is why for measurements that are performed with different wavelengths it is very important to change the curvature of the neutron guide in order to obtain optimal results. In this work we have designed, constructed and tested a guide where we can change the curvature during the experiment. In this way we can obtain a variable curvature in horizontal as well as in vertical direction. For a curvature in the horizontal or vertical direction it is not necessary to move all four walls, only two of the opposed plates. The element that changes the curvature of the guide consists of an acting element (piezomotor) as well as a rod that can be operated by the piezomotor and that acts through a lever onto the plate. The action of a force and a consecutive torsion momentum at the free end of the plate changes the curvature of the whole plate in an almost parabolic way. Making use of the Monte Carlo simulations we were able to determine the optimal curvature for each wavelength of a neutron guide for the spectrometer TOFTOF installed at the Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II). First tests have shown that with an adaptive focusing guide one can gain up to a factor three in intensity at

  1. Focusing of light beyond the diffraction limit

    CERN Document Server

    Chen, K R

    2009-01-01

    Diffraction limits the behaviour of light in optical systems and sets the smallest achievable line width at half the wavelength. With a novel subwavelength plasmonic lens to reduce the diffraction via an asymmetry and to generate and squeeze the wave functions, an incident light is focused by the aperture to a single-line with its width beyond the limit outside the near zone. The fields focused are radiative and capable of propagating to the far zone. The light focusing process, besides being of academic interest, is expected to open up a wide range of application possibilities.

  2. Eating regulation and bulimic symptoms: the differential correlates of health-focused and appearance-focused eating regulation.

    Science.gov (United States)

    Verstuyf, Joke; Vansteenkiste, Maarten; Soenens, Bart

    2012-01-01

    Based on Self-Determination Theory, this study aimed to gain further insight in the pathway from eating regulation to bulimic symptoms by (a) examining diet-specific need frustration as an intervening mechanism, (b) investigating the associations between different types of goals underlying eating regulation and diet-specific need frustration and bulimic symptoms, and (c) considering body dissatisfaction as an antecedent of eating regulation and eating regulation goals. In a sample of 244 female adolescents, SEM analyses showed that (a) the association between eating regulation and bulimic symptoms can be accounted for by need frustration, (b) appearance-focused and health-focused eating regulation are associated differentially with need frustration and bulimic symptoms, and (c) body dissatisfaction is related positively to eating regulation and appearance-focused eating regulation. These findings suggest that the goals underlying one's eating regulation and the concept of need frustration help to understand when and why eating regulation is associated with bulimic symptoms.

  3. Introduction to Focus Issue: Patterns of Network Synchronization

    CERN Document Server

    Abrams, Daniel M; Motter, Adilson E

    2016-01-01

    The study of synchronization of coupled systems is currently undergoing a major surge fueled by recent discoveries of new forms of collective dynamics and the development of techniques to characterize a myriad of new patterns of network synchronization. This includes chimera states, phenomena determined by symmetry, remote synchronization, and asymmetry-induced synchronization. This Focus Issue presents a selection of contributions at the forefront of these developments, to which this introduction is intended to offer an up-to-date foundation.

  4. Mathematical simulation of steep waves at a focus point

    Institute of Scientific and Technical Information of China (English)

    XU Li; ZHANG Min; WANG Yan-ying

    2007-01-01

    Mathematical models simulating steep waves at a focus point are presented in this paper. Simulations of extreme waves in a model basin were used to determine the loads on floating structures induced by the waves. Based on a new wave theory, numerical test results show that the simulation procedure is effective and the induced motion of water particles in the front of waves is an important factor influencing impact loads on floating bodies.

  5. Attentional Focus in Classical Ballet: A Survey Of Professional Dancers.

    Science.gov (United States)

    Guss-West, Clare; Wulf, Gabriele

    2016-03-01

    Focus of attention and its effects on skilled motor performance has become an important line of research in the motor learning domain. Numerous studies have demonstrated that an external focus of attention (i.e., on the movement effect) enhances motor performance and learning relative to an internal focus (i.e., on body movements). Thus, small differences in the wording of instructions or feedback given by teachers can have a significant impact on the effectiveness and efficiency of motor skill performance. In this paper, we review some of the attentional focus studies that are relevant to ballet performance. In addition, we report the findings of a survey among professional ballet dancers (N = 53) that we conducted to determine their typical attentional focus while performing certain movements. The results showed that the majority adopted internal foci, or combinations of internal and external foci, most of the time. This suggests that there is room for improvement for performance and teaching. We provide examples of how external foci can be promoted in ballet practice.

  6. Focusing of high-wave-vector magnons

    Science.gov (United States)

    Bible, J. J.; Camley, R. E.

    2017-06-01

    The focusing of spin waves in magnetic materials has a number of important advantages for directing energy and thus information. In contrast to earlier works, we theoretically calculate the focusing of short-wavelength spin waves. We show that strong focusing of large wave-vector spin waves naturally occurs about halfway out in the Brillouin zone with no need for a magnetocrystalline anisotropy, dipolar effects, or an external magnetic field. The fact that the wavelength is on the order of the lattice constant leads to a form of lattice-induced anisotropy in the wave propagation. We also explore the tunability that is achieved by the application of both an external field and a uniaxial anisotropy. In this case there is a rotation of the focusing pattern. The rotation angle can be changed by varying the field strength, demonstrating tunability.

  7. NPS Focus Digital Library and Research Station

    Data.gov (United States)

    National Park Service, Department of the Interior — Scope: National. NPS Focus Digital Library and Research Station information system manages images and archives of images as well as documents described by linked...

  8. Optical sharper focusing in an anisotropic crystal.

    Science.gov (United States)

    Wang, Sicong; Xie, Xiangsheng; Gu, Min; Zhou, Jianying

    2015-06-01

    Optical super-resolution technique through tight focusing is a widely used technique to image material samples with anisotropic optical properties. The knowledge of the field distribution of a tightly focused beam in anisotropic media is both scientifically interesting and technologically important. In this paper, the optical properties of a uniaxial crystal with the optic axis perpendicular to the interface under a tight focusing configuration are studied with rigorous theoretical and numerical analysis. The significant effect of the Poynting vector on the focal position introduces an obvious displacement of the focal spot formed by the extraordinary waves (e-ray). Moreover, a sharper focus with a lateral size of 0.22λ is obtained as a result of the effective separation of the ordinary waves (o-ray) and the e-ray. It provides a new tool to fabricate optical structures with higher resolutions than that in an isotropic medium through the far-field method.

  9. Social Work Intervention Focused on Transitions

    Science.gov (United States)

    2016-12-19

    Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention; Heart Disease; Diabetes; Hypertension; Cancer; Depression; Asthma; Chronic Heart Failure; Chronic Obstructive Pulmonary Disease; Stroke

  10. A New Framework for Focused Web Crawling

    Institute of Scientific and Technical Information of China (English)

    PENG Tao; HE Fengling; ZUO Wanli

    2006-01-01

    Focused crawlers are important tools to support applications such as specialized Web portals, online searching, and Web search engines.A topic driven crawler chooses the best URLs and relevant pages to pursue during Web crawling.It is difficult to deal with irrelevant pages.This paper presents a novel focused crawler framework.In our focused crawler, we propose a method to overcome some of the limitations of dealing with the irrelevant pages.We also introduce the implementation of our focused crawler and present some important metrics and an evaluation function for ranking pages relevance.The experimental result shows that our crawler can obtain more "important" pages and has a high precision and recall value.

  11. Range-Based Auto-Focus Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Maracel Systems and Software Technologies, LLC proposes a revolutionary Range-Based Auto Focus (RBAF) system that will combine externally input range, such as might...

  12. Focus and Higher-Order Unification

    CERN Document Server

    Gardent, C; Gardent, Claire; Kohlhase, Michael

    1996-01-01

    Pulman has shown that Higher--Order Unification (HOU) can be used to model the interpretation of focus. In this paper, we extend the unification--based approach to cases which are often seen as a test--bed for focus theory: utterances with multiple focus operators and second occurrence expressions. We then show that the resulting analysis favourably compares with two prominent theories of focus (namely, Rooth's Alternative Semantics and Krifka's Structured Meanings theory) in that it correctly generates interpretations which these alternative theories cannot yield. Finally, we discuss the formal properties of the approach and argue that even though HOU need not terminate, for the class of unification--problems dealt with in this paper, HOU avoids this shortcoming and is in fact computationally tractable.

  13. CRISIS FOCUS Fundamentals,Confidence and Policy

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Entering the third year of the most serious economic crisis since the Great Depression, the world economy is still bogged down on the muddy road to recovery. The latest edition of Standard Chartered Bank’s monthly report, Global Focus,

  14. Comparing and Using Occupation-Focused Models.

    Science.gov (United States)

    Wong, Su Ren; Fisher, Gail

    2015-01-01

    As health care moves toward understanding the importance of function, participation and occupation, occupational therapists would be well served to use occupation-focused theories to guide intervention. Most therapists understand that applying occupation-focused models supports best practice, but many do not routinely use these models. Barriers to application of theory include lack of understanding of the models and limited strategies to select and apply them for maximum client benefit. The aim of this article is to compare occupation-focused models and provide recommendations on how to choose and combine these models in practice; and to provide a systematic approach for integrating occupation-focused models with frames of reference to guide assessment and intervention.

  15. Personnel marketing focused on graduates' attraction

    OpenAIRE

    Solovská, Petra

    2012-01-01

    This diploma thesis refers to the topic of personnel marketing focused on graduates' attraction. In theoretical part it describes concepts of personnel marketing, its components, tools and parts, then it focuses on personnel marketing in a context of social system of organization and on specifics of graduates. The empirical part is searching for answers why is it important for organizations to attract graduates, which methods of personnel marketing are used to attract them, what is the strate...

  16. Utilization-focused evaluation for agricultural innovation

    OpenAIRE

    Patton, Michael Quinn; Horton, Douglas

    2008-01-01

    Utilization-focused evaluation (UFE) is based on the principle that an evaluation should be judged by its utility. So no matter how technically sound and methodologically elegant, an evaluation is not truly a good evaluation unless the findings are used. UFE is a framework for enhancing the likelihood that evaluation findings will be used and lessons will be learnt from the evaluation process. This Brief, based on the book Utilization-focused evaluation, introduces this approach to evaluation...

  17. Molecular focusing and alignment with plasmon fields.

    Science.gov (United States)

    Artamonov, Maxim; Seideman, Tamar

    2010-12-01

    We show the possibility of simultaneously aligning molecules and focusing their center-of-mass motion near a metal nanoparticle in the field intensity gradient created by the surface plasmon enhancement of incident light. The rotational motion is described quantum mechanically while the translation is treated classically. The effects of the nanoparticle shape on the alignment and focusing are explored. Our results carry interesting implications to the field of molecular nanoplasmonics and suggest several potential applications in nanochemistry.

  18. Regulatory focus and the assignment of punishment

    Directory of Open Access Journals (Sweden)

    Chloe Carmichael

    2007-06-01

    Full Text Available Regulatory Focus has been demonstrated to influence human behavior in a number of domains, such as object valuation and readiness to commit time or money to social projects. It has also been demonstrated to influence an individual’s approach to mistakes; and a person’s preference for global or local processing of information. The present work seeks to consider how regulatory focus might interact with punitive behaviors, specifically, the assignment of legal punishment. In this study, 240 undergraduates completed a series of written instruments that assessed their regulatory focus. They read a vignette that described a target that commits a crime, is detected by the police, and is arrested due to a careless mistake. Participants were asked what level of legal punishment they deemed appropriate. Participants’ punitive evaluations show that there are significant interactions a between the regulatory focus of the participant and the regulatory focus of the target and b between the regulatory focus of the participant and the level of detail used to describe the target and her behavior. In each case, when the regulatory foci matched, causing ‘fit,’ the participant was more lenient than in the non-fit condition.

  19. EPA Region 7 Aquatic Focus Areas (ECO_RES.R7_AQUATIC_FOCUS_AREAS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This shapefile consists of 347 individual Aquatic Ecological System (AES) polygons that are the Aquatic Conservation Focus Areas for EPA Region 7. The focus areas...

  20. Followers feel valued : When leaders' regulatory focus makes leaders exhibit behavior that fits followers' regulatory focus

    NARCIS (Netherlands)

    Hamstra, Melvyn; Sassenberg, K.; Van Yperen, Nico W.; Wisse, Barbara

    2014-01-01

    When do followers feel valued by their leader? We propose that leaders' regulatory focus can make followers feel valued when leaders' regulatory focus is the same as followers' regulatory focus, that is, when there is regulatory fit between leaders and followers. We further propose that the reason w

  1. Efficacy of Child-Focused and Parent-Focused Interventions in a Child Anxiety Prevention Study

    Science.gov (United States)

    Simon, Ellin; Bogels, Susan Maria; Voncken, Jannie Marisol

    2011-01-01

    This study examined anxiety development in median- (n = 74) and high-anxious children (n = 183) aged 8-13, the effect of parent- and child-focused preventive interventions on child/parental anxiety, and the effect of parental anxiety on child anxiety. High-anxious children were randomized into a parent-focused (n = 69), child-focused (n = 58) or…

  2. Phase analysis and focusing of synchrotron radiation

    CERN Document Server

    Chubar, O; Snigirev, A

    1999-01-01

    High accuracy calculations of synchrotron radiation (SR) emitted by a relativistic electron show that the phase of the frequency domain electric field of SR differs from the phase of radiation of a virtual point source. These differences may result in the reduction of focusing efficiency of diffraction-limited SR, if the focusing is performed by conventional optical components optimised for point sources. We show that by applying a phase correction locally, one may transform the phase of SR electric field at a desired polarisation to that of a point source. Such corrections are computed for undulator radiation (planar and helical) and bending magnet radiation (central part and edges). The focusing of the corrected SR wavefront can result in the increase of peak intensity in the focused spot up to several times compared to the focusing without correction. For non-diffraction-limited radiation, the effect of the phase corrections is reduced. Due to this reason, the use of the proposed phase corrections in exist...

  3. Task-focused modeling in automated agriculture

    Science.gov (United States)

    Vriesenga, Mark R.; Peleg, K.; Sklansky, Jack

    1993-01-01

    Machine vision systems analyze image data to carry out automation tasks. Our interest is in machine vision systems that rely on models to achieve their designed task. When the model is interrogated from an a priori menu of questions, the model need not be complete. Instead, the machine vision system can use a partial model that contains a large amount of information in regions of interest and less information elsewhere. We propose an adaptive modeling scheme for machine vision, called task-focused modeling, which constructs a model having just sufficient detail to carry out the specified task. The model is detailed in regions of interest to the task and is less detailed elsewhere. This focusing effect saves time and reduces the computational effort expended by the machine vision system. We illustrate task-focused modeling by an example involving real-time micropropagation of plants in automated agriculture.

  4. Focus Groups as Transformative Spiritual Encounters

    Directory of Open Access Journals (Sweden)

    Sharon Moloney PhD

    2011-03-01

    Full Text Available Focus groups are a valuable method for exploring the construction and negotiation of meanings. In her doctoral research the author explored how Australian women's experiences of menstruation, birth, and spirituality are invested with meaning and how that meaning influences and shapes those experiences. The focus group has been described as a potentially liminal space, which enables the discussion of taboo subjects by breaking the ice and giving people permission to comment. In addition, she discovered that the groups could be occasions of empowerment and transformation for both participants and researcher. In a way that far exceeded her expectations, the group format was ideally suited to feminist research and the organic inquiry methodology she used. Some groups became deeply spiritual encounters that were nourishing and transformative for all. This article explores how focus groups can be vehicles of spiritual transformation, examining one group in particular to highlight the points raised.

  5. A high resolution hand-held focused beam profiler

    Science.gov (United States)

    Zapata-Farfan, J.; Garduño-Mejía, J.; Rosete-Aguilar, M.; Ascanio, G.; Román-Moreno, C. J.

    2017-05-01

    The shape of a beam is important in any laser application and depending on the final implementation, there exists a preferred one which is defined by the irradiance distribution.1 The energy distribution (or laser beam profile) is an important parameter in a focused beam, for instance, in laser cut industry, where the beam shape determines the quality of the cut. In terms of alignment and focusing, the energy distribution also plays an important role since the system must be configured in order to reduce the aberration effects and achieve the highest intensity. Nowadays a beam profiler is used in both industry and research laboratories with the aim to characterize laser beams used in free-space communications, focusing and welding, among other systems. The purpose of the profile analyzers is to know the main parameters of the beam, to control its characteristics as uniformity, shape and beam size as a guide to align the focusing system. In this work is presented a high resolution hand-held and compact design of a beam profiler capable to measure at the focal plane, with covered range from 400 nm to 1000 nm. The detection is reached with a CMOS sensor sized in 3673.6 μm x 2738.4 μm which acquire a snap shot of the previously attenuated focused beam to avoid the sensor damage, the result is an image of beam intensity distribution, which is digitally processed with a RaspberryTMmodule gathering significant parameters such as beam waist, centroid, uniformity and also some aberrations. The profiler resolution is 1.4 μm and was probed and validated in three different focusing systems. The spot sizes measurements were compared with the Foucault knife-edge test.

  6. Optical illumination and critical dimension analysis using the through-focus focus metric method

    Science.gov (United States)

    Attota, Ravikiran; Silver, Richard M.; Potzick, James

    2006-08-01

    In this paper we present recent developments in optical microscope image analysis using both, best focus optical image as well as those images conventionally considered out of focus for metrology applications. Depending on the type of analysis, considerable information can be deduced with the additional use of the out of focus optical images. One method for analyzing the complete set of images is to calculate the total "edge slope" from an image, as the target is moved through-focus. A plot of the sum of the mean square slope is defined as the through-focus focus metric. We present a unique method for evaluating the angular illumination homogeneity in an optical microscope (with Koehler illumination configuration), based on the through-focus focus metric approach. Both theoretical simulations and experimental results are presented to demonstrate this approach. We present a second application based on the through-focus focus metric method for evaluating critical dimensions (CD) with demonstrated nanometer sensitivity for both experimental and optical simulations. An additional approach to analyzing the complete set of images is to assemble or align the through focus image intensity profiles such that the x-axis represents the position on the target, the y-axis represents the focus (or defocus) position of the target with respect to the lens and the z-axis represents the image intensity. This two-dimensional image is referred to as the through focus image map. Using recent simulation results we apply the through focus image map to CD and overlay analysis and demonstrate nanometer sensitivity in the theoretical results.

  7. Radiation Damping in a Focusing Channel

    Science.gov (United States)

    Ruth, Ronald D.

    1996-05-01

    In electron storage rings synchrotron radiation leads to the damping of the three degrees of freedom of the particle trajectory towards a stable closed orbit transversely and a fixed stable phase longitudinally. At the same time, the emission of discrete quanta leads to diffusion in all three degrees of freedom. These two competing effects result in an equilibrium beam emittance that depends upon the parameters of the storage ring. In the case above, the radiation in the bending fields dominates, and the radiation due to the focusing fields is either neglected or taken into account perturbatively. In this talk we study the opposite case, a continuous focusing channel in which the radiation and its reaction are dominated by the strong focusing field. If there is a bending field, it is much weaker than the focusing field. In such focusing systems, we find that the radiation is synchrotron-like for larger betatron oscillation amplitudes and undulator-like for smaller amplitudes. However, quantum excitation is absent for any oscillation amplitude, and the damping exhibits asymmetry in favor of the transverse degree of freedom as the amplitude becomes smaller. In the undulator regime, the damping turns into exponential in the transverse direction, much faster than the total energy damping in this system. In principle, the particle could damp to the transverse ground state of the harmonic oscillator, reaching a minimum normalized emittance, γ ɛ_min = hbar/2mc, limited only by the uncertainty principle. In the case of a bent focusing system, we find that the lack of quantum excitation and asymmetric damping still hold provided that the bending field is sufficiently weak.

  8. Dynamic focusing in the zebrafish beating heart

    Science.gov (United States)

    Andrés-Delgado, L.; Peralta, M.; Mercader, N.; Ripoll, J.

    2016-03-01

    Of the large amount of the animal models available for cardiac research, the zebrafish is extremely valuable due to its transparency during early stages of development. In this work a dual illumination laser sheet microscope with simultaneous dual camera imaging is used to image the beating heart at 200 fps, dynamically and selectively focusing inside the beating heart through the use of a tunable lens. This dual color dynamic focusing enables imaging with cellular resolution at unprecedented high frame rates, allowing 3D imaging of the whole beating heart of embryonic zebrafish.

  9. Focusing of branes in warped backgrounds

    CERN Document Server

    Kar, S

    2006-01-01

    Branes are embedded surfaces in a given background (bulk) spacetime. Assuming a warped bulk, we investigate, in analogy with the case for geodesics, the notion of {\\em focusing} of families of such embedded, extremal 3--branes in a five dimensional background . The essential tool behind our analysis, is the well-known generalised Raychaudhuri equations for surface congruences. In particular, we find explicit solutions of these equations, which seem to show that families of 3--branes can focus along lower dimensional submanifolds depending on where the initial expansions are specified. We conclude with comments on the results obtained and possibilities about future work along similar lines.

  10. Focus point supersymmetry in extended gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Ran [School of Physics, Nankai University,Tianjin 300071 (China); Li, Tianjun [State Key Laboratory of Theoretical Physics and Kavli Institute for Theoretical Physics (KITPC),Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190 (China); School of Physical Electronics, University of Electronic Science and Technology of China,Chengdu 610054 (China); Staub, Florian [Bethe Center for Theoretical Physics & Physikalisches Institut der Universität Bonn,Nußallee 12, 53115 Bonn (Germany); Zhu, Bin [School of Physics, Nankai University,Tianjin 300071 (China)

    2014-03-27

    We propose a small extension of the minimal gauge mediation through the combination of extended gauge mediation and conformal sequestering. We show that the focus point supersymmetry can be realized naturally, and the fine tuning is significantly reduced compared to the minimal gauge mediation and extended gauge mediation without focus point. The Higgs boson mass is around 125 GeV, the gauginos remain light, and the gluino is likely to be detected at the next run of the LHC. However, the multi-TeV squarks is out of the reach of the LHC. The numerical calculation for fine-tuning shows that this model remains natural.

  11. Architecture and Energy. Towards a broader Focus

    DEFF Research Database (Denmark)

    Lauring, Michael; Marsh, Rob

    % hot water. 65% of the primary energy use is related to electricity driven purposes such as cooling, ventilation, pumps, lighting and appliances. In new office buildings the figures are 16% for room heating and 5% for hot water while 79% goes to other purposes driven by electricity[1]. As the global...... temperatures rise, the need for room heating will go down, while the need for cooling will go up. The strategies for low energy buildings therefore cannot focus only on heating, but must have a much wider scope. Architects cannot focus only on the building envelope, but must consider also the spatial...

  12. Radiation Reaction in a Continuous Focusing Channel

    Science.gov (United States)

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.

    1995-03-01

    We show that the radiation damping rate of the transverse action of a particle in a straight, continuous focusing system is independent of the particle energy, and that no quantum excitation is induced. This absolute damping effect leads to the existence of a transverse ground state to which the particle inevitably decays and yields the minimum beam emittance that one can ever attain, γɛmin = /2mc, limited only by the uncertainty principle. Because of adiabatic invariance, the particle can be accelerated along the focusing channel in its ground state without any radiation energy loss.

  13. Light focusing in the Anderson Regime

    CERN Document Server

    Leonetti, Marco; Mafi, Arash; Conti, Claudio

    2014-01-01

    Anderson localization is a regime in which diffusion is inhibited and waves (also electromagnetic waves) get localized. Here we exploit adaptive optics to achieve focusing in disordered optical fibers in the Anderson regime. By wavefront shaping and optimization, we observe the generation of a propagation invariant beam, where light is trapped transversally by disorder, and show that Anderson localizations can be also excited by extended speckled beams. We demonstrate that disordered fibers allow a more efficient focusing action with respect to standard fibers in a way independent of their length, because of the propagation invariant features and cooperative action of transverse localizations.

  14. Optimal spatiotemporal focusing through complex scattering media

    CERN Document Server

    Aulbach, Jochen; Fink, Mathias; Tanter, Mickaël; Tourin, Arnaud; 10.1103/PhysRevE.85.016605

    2013-01-01

    We present a new approach for spatiotemporal focusing through complex scattering media by wave front shaping. Using a nonlinear feedback signal to shape the incident pulsed wave front, we show that the limit of a spatiotemporal matched filter can be achieved, i.e., the wave amplitude at the intended time and focus position is maximized for a given input energy. It is exactly what is also achieved with time-reversal. Demonstrated with ultrasound experiments, our method is generally applicable to all types of waves.

  15. Detonation onset following shock wave focusing

    Science.gov (United States)

    Smirnov, N. N.; Penyazkov, O. G.; Sevrouk, K. L.; Nikitin, V. F.; Stamov, L. I.; Tyurenkova, V. V.

    2017-06-01

    The aim of the present paper is to study detonation initiation due to focusing of a shock wave reflected inside a cone. Both numerical and experimental investigations were conducted. Comparison of results made it possible to validate the developed 3-d transient mathematical model of chemically reacting gas mixture flows incorporating hydrogen - air mixtures. The results of theoretical and numerical experiments made it possible improving kinetic schemes and turbulence models. Several different flow scenarios were detected in reflection of shock waves all being dependent on incident shock wave intensity: reflecting of shock wave with lagging behind combustion zone, formation of detonation wave in reflection and focusing, and intermediate transient regimes.

  16. Focusing America’s National Powers

    Science.gov (United States)

    2006-04-14

    1 Frontline, “Osama Bin Laden v. The U.S.: Edicts and Statements,” 22 February 1998, http://www.pbs.org/wgbh/pages/frontline/shows...The U.S.: Edicts and Statements,” 22 February 1998, available from Focusing America’s National Powers Bibliography A-3 http://www.pbs.org/wgbh/pages...title=Gulf_War&oldid=34572905 , accessed 11 Jan 06. Vego, Milan N., Operational Warfare, 2000. Focusing America’s National Powers Bibliography A-6 The

  17. Focus issue introduction: optical cooling and trapping.

    Science.gov (United States)

    Neves, Antonio A R; Jones, Philip H; Luo, Le; Maragò, Onofrio M

    2015-04-20

    The year 2015 is an auspicious year for optical science, as it is being celebrated as the International Year of Light and Light-Based Technologies. This Focus Issue of the journals Optics Express and Journal of the Optical Society of America B has been organized by the OSA Technical Group on Optical Cooling and Trapping to mark this occasion, and to highlight the most recent and exciting developments in the topics covered by the group. Together this joint Focus Issue features 32 papers, including both experimental and theoretical works, which span this wide range of activities.

  18. Final Focus Test Stand final report

    CERN Document Server

    Jeremie, A; Burrows, P

    2013-01-01

    Future Linear colliders will need particle beam sizes in the nanometre range. The beam also needs to be stable all along the beam line and especially at the Final Focus section. A dedicated Final Focus test stand has been used for this study and is comprised of several sub-parts. First there is the Stabilisation/Isolation system with sensors and actuators stabilizing down to sub-nanometre level. Then the Magnet itself needs to comply with very specific design constraints. In addition to the mechanical items, the beam can be stabilized acting on the trajectory directly and Beam-based controls have been developed and tested on different accelerator facilities.

  19. Structured light for focusing surface plasmon polaritons.

    Science.gov (United States)

    Hu, Z J; Tan, P S; Zhu, S W; Yuan, X-C

    2010-05-10

    We propose a structureless method for focusing surface plasmon polaritons (SPPs) on a flat metal film under illumination of radially polarized cogwheel-like structured light beams. Without metal structures, the locally induced SPPs can further be propagated following the predefined patterns to form symmetric focal spots with dimensions beyond diffraction limit. Benefiting from the radial polarization, this method can be employed to pattern various center-symmetric evanescent distributions for generating SPPs reconfigurably. The SPPs will be propagating and focusing in radial directions.

  20. CY15 Livermore Computing Focus Areas

    Energy Technology Data Exchange (ETDEWEB)

    Connell, Tom M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Cupps, Kim C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); D' Hooge, Trent E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fahey, Tim J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fox, Dave M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Futral, Scott W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gary, Mark R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Goldstone, Robin J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Hamilton, Pam G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heer, Todd M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Long, Jeff W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mark, Rich J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Morrone, Chris J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Shoopman, Jerry D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Slavec, Joe A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Smith, David W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Springmeyer, Becky R [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Stearman, Marc D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Watson, Py C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-01-20

    The LC team undertook a survey of primary Center drivers for CY15. Identified key drivers included enhancing user experience and productivity, pre-exascale platform preparation, process improvement, data-centric computing paradigms and business expansion. The team organized critical supporting efforts into three cross-cutting focus areas; Improving Service Quality; Monitoring, Automation, Delegation and Center Efficiency; and Next Generation Compute and Data Environments In each area the team detailed high level challenges and identified discrete actions to address these issues during the calendar year. Identifying the Center’s primary drivers, issues, and plans is intended to serve as a lens focusing LC personnel, resources, and priorities throughout the year.

  1. Sex determination

    OpenAIRE

    McCullagh, W. McK. H.

    2013-01-01

    How the sex of offspring is determined has puzzled philosophers and scientists for millennia. Modern science has identified both genetic and environmental factors, but the question is still not yet fully answered.

  2. 2. Determinants

    African Journals Online (AJOL)

    Sitwala

    ... P.O Box 50110, Lusaka. National Food and Nutrition Commission, Ministry of Health, Lusaka ... malnourished case of admissions among HIV infected children and were .... However, service factors emerged as important determinants during.

  3. Study on focusing performance of the twice reflecting laser focusing system

    Energy Technology Data Exchange (ETDEWEB)

    Fu Qiangcheng [Company of Postgraduate Management, Academy of Equipment Command and Technology, Beijing 101416 (China); Zhi Guodou, E-mail: nazis76@163.com [Department of Basic Theories, Academy of Equipment Command and Technology, Beijing 101416 (China)

    2011-02-01

    Laser thrusters characterized by feasible application perspective all possess the twice reflecting laser focusing system. Nonetheless, studies on its focusing performance are imperative for the research of flight route of the thruster and haven't been developed yet. Under three different focusing design modes, assisted with optical design software ZEMAX which employing Monte Carlo ray tracing, performance of twice reflecting laser focusing system including focusing performance parameters, radiation intensity distribution and the details of ignition region on the focusing plane are studied comparatively, and the studied two main angular aberrations are beam out-coming aberration from laser source and flying aberration from thruster itself. Studies show even slight aberration will result in steep falling focusing performance and strong deviation of beam spot for any focusing design mode, while different aberrations bring in distinctive falling tendencies and the evolutions of ignition region. It strongly demands the directional precision of laser beam, and the attitude control of laser thruster is indispensable. And it's not recommended that one focusing design mode is superior to another. Which kind of aberration is dominant should be taken into account when choosing focusing mode.

  4. Laterally focused attention modulates asymmetric coupling in rhythmic interlimb coordination.

    Science.gov (United States)

    de Poel, Harjo J; Peper, C Lieke E; Beek, Peter J

    2008-03-01

    Peters (J Motor Behav 21:151-155, 1989; Interlimb coordination: neural, dynamical and cognitive constraints, Academic, Orlando, pp 595-615, 1994) suggested that expressions of handedness in bimanual coordination may be reflections of an inherent attentional bias. Indeed, previous results indicated that focusing attention on one of the limbs affected the relative phasing between the limbs in a manner comparable to the effects of hand dominance. The present study extended the comparison between the effects of attentional focus and handedness by testing their impact on the interactions between the limbs. Both left-handed and right-handed participants performed rhythmic bimanual coordination tasks (in-phase and antiphase coordination), while directing attention to either limb. Using brief mechanical perturbations, the degree to which the limbs were influenced by each other was determined. The results revealed that the non-dominant limb was more strongly affected by the dominant limb than vice versa and that, in line with Peters' proposition, this handedness-related asymmetry in coupling strength was reduced when attention was focused on the non-dominant limb, thereby highlighting the potential relation between inherent (handedness-related) asymmetries and voluntary attentional asymmetries. In contrast to previous findings, the (commonly observed) phase lead of the dominant limb was attenuated (rather than accrued) when attention was focused on this limb. This unexpected result was explained in terms of the observed attention-related difference in amplitude between the limbs.

  5. Analytical performance of an ultrasonic particle focusing flow cytometer.

    Science.gov (United States)

    Goddard, Gregory R; Sanders, Claire K; Martin, John C; Kaduchak, Gregory; Graves, Steven W

    2007-11-15

    Creation of inexpensive small-flow cytometers is important for applications ranging from disease diagnosis in resource-poor areas to use in distributed sensor networks. In conventional-flow cytometers, hydrodynamics focus particles to the center of a flow stream for analysis, which requires sheath fluid that increases consumable use and waste while dramatically reducing instrument portability. Here we have evaluated, using quantitative measurements of fluorescent microspheres and cells, the performance of a flow cytometer that uses acoustic energy to focus particles to the center of a flow stream. This evaluation demonstrated measurement precision for fluorescence and side scatter CVs for alignment microspheres of 2.54% and 7.7%, respectively. Particles bearing 7 x 10(3) fluorophores were well resolved in a background of 50 nM free fluorophore. The lower limit of detection was determined to be about 650 fluorescein molecules. Analysis of Chinese hamster cells on the system demonstrated that acoustic focusing had no effect on cellular viability. These results indicate that the ultrasonic flow cytometer has the necessary performance for most flow cytometry applications. Furthermore, through robust engineering approaches and the combination of acoustic focusing with low-cost light sources, detectors, and data acquisition systems, it will be possible to achieve a low-cost, truly portable flow cytometer.

  6. Attentional Focus Effects in Standing Long Jump Performance: Influence of a Broad and Narrow Internal Focus.

    Science.gov (United States)

    Becker, Kevin A; Smith, Peter J K

    2015-07-01

    The content of instructions that strength coaches give can have a significant impact on how an athlete or client performs. Research on motor learning has shown an advantage of instructions focusing on the effects of movements (external focus) over those focusing on the movements themselves (internal focus) in the performance of motor skills. Internally focused cues are abundant in coaching, therefore the purpose of this study was to test whether some internally focused cues might be more helpful than others. Participants (68) were randomly assigned to either an external focus (EX), broad internal focus (B-IN), narrow internal focus (N-IN), or a control group (CON), and performed 5 standing long jumps. All groups were instructed that the goal was to jump as far as possible. In addition, the EX group was told to "jump as far past the start line as possible." The B-IN group was told to "use your legs." The N-IN group was told to "extend your knees as rapidly as possible," and the CON group received no additional instruction. An analysis of covariance showed that the EX group (198.09 ± 31.89 cm) jumped significantly farther than both the B-IN group (173.74 ± 35.36 cm), p = 0.010 and the N-IN group (178.53 ± 31.17 cm), p = 0.049, with no group different from the CON group. The results suggest that a broad internal focus is no more effective than a narrow internal focus, and that an external focus leads to the greatest jump distance. Strength and conditioning professionals should carefully word their instructions to induce an external focus of attention whenever possible.

  7. Flexural waves focusing through shunted piezoelectric patches

    Science.gov (United States)

    Yi, K.; Collet, M.; Ichchou, M.; Li, L.

    2016-07-01

    In this paper, we designed and analyzed a piezo-lens to focus flexural waves in thin plates. The piezo-lens is comprised of a host plate and piezoelectric arrays bonded on the surfaces of the plate. The piezoelectric patches are shunted with negative capacitance circuits. The effective refractive indexes inside the piezo-lens are designed to fit a hyperbolic secant distribution by tuning the negative capacitance values. A homogenized model of a piezo-mechanical system is adopted in the designing process of the piezo-lens. The wave focusing effect is studied by the finite element method. Numerical results show that the piezo-lens can focus flexural waves by bending their trajectories, and is effective in a large frequency band. The piezo-lens has the ability to focus flexural waves at different locations by tuning the shunting negative capacitance values. The piezo-lens is shown to be effective for flexural waves generated by different types of sources.

  8. Focus. Volume 27, Number 2, Winter 2010

    Science.gov (United States)

    Caspar, Emma, Ed.

    2010-01-01

    The purpose of "Focus" is to provide coverage of poverty-related research, events, and issues, and to acquaint a large audience with the work of the Institute for Research on Poverty by means of short essays on selected pieces of research. This issue contains the following articles: (1) Progress toward Improving the U.S. Poverty Measure:…

  9. Expanding the Focus of Career Assessment.

    Science.gov (United States)

    Lock, Jared D.; Hogan, Robert

    2000-01-01

    Issues affecting career assessment include change in the focus and definition of career, emphasis on quality of work life, expansion of career paths, increased amount of career information available on the Internet, and questionable quality of online assessment. An expanded model of career assessment now includes technical fit, personal fit,…

  10. Self-focused Attention in Anorexia Nervosa

    Science.gov (United States)

    Zucker, Nancy; Wagner, H. Ryan; Merwin, Rhonda; Bulik, Cynthia M.; Moskovich, Ashley; Keeling, Lori; Hoyle, Rick

    2015-01-01

    Objective The clinical presentation of anorexia nervosa (AN) is characterized by preoccupation with body experience, intrusive concerns regarding shape, and pathological fears of weight gain. These symptoms are suggestive of unrelenting self-focused attention. No research to date has characterized self-focused attention (SFA) in AN nor examined neurocognitive features that may facilitate an excessive, rigid, or sustained focus on one’s appearance. Method This study examined SFA, body image disturbance, and executive functioning in women with current anorexia nervosa (AN-C; n = 24), a history of AN who were weight-restored at the time of the study weight-restored (WR; n = 19), and healthy controls (n = 24). Results Private and public SFA were highest among WR and lowest among AN-C. Shape concerns were negatively correlated with SFA, especially among AN-C, after controlling for depression and social anxiety symptoms. Discussion Lower levels of SFA among AN-C were unexpected and suggest the acute state of AN may lessen pathological self-focus, negatively reinforcing symptoms. In addition, body image concerns may distract from general SFA. Deficits in executive attention may explain these findings, as each one unit increase in perseverative errors among AN-C participants was associated with an almost one-half unit decrease in public SFA. PMID:24899215

  11. Tight Focusing of Partially Coherent Vortex Beams

    Directory of Open Access Journals (Sweden)

    Rakesh Kumar Singh

    2012-01-01

    Full Text Available Tight focusing of partially polarized vortex beams has been studied. Compact form of the coherence matrix has been derived for polarized vortex beams. Effects of topological charge and polarization distribution of the incident beam on intensity distribution, degree of polarization, and coherence have been investigated.

  12. Research Assistant Training Manual: Focus Groups

    Science.gov (United States)

    Eaton, Sarah Elaine

    2017-01-01

    This manual is a practical training guide for graduate and undergraduate research assistants (RAs) working in the Werklund School of Education, University of Calgary. It may also be applicable to research assistants working in other fields or institutions. The purpose of this manual is to train RAs on how to plan and conduct focus groups for…

  13. An Environmentally Focused General Chemistry Laboratory

    Science.gov (United States)

    Mihok, Morgan; Keiser, Joseph T.; Bortiatynski, Jacqueline M.; Mallouk, Thomas E.

    2006-01-01

    The environmentally focused general chemistry laboratory provides a format for teaching the concepts of the mainstream laboratory within an environmental context. The capstone integrated exercise emerged as the overwhelming favorite part of this laboratory and the experiment gave students an opportunity to do a self-directed project, using the…

  14. Organisational Change: A Solution-Focused Approach

    Science.gov (United States)

    Morgan, Gavin

    2016-01-01

    This study investigates the effectiveness of a solution-focused approach to organisational change. Planning Alternative Tomorrows with Hope (PATH) is an intervention more commonly applied to individuals. In this study the intervention is used with groups of people working in educational organisations to help manage the change process. The approach…

  15. High throughput-per-footprint inertial focusing.

    Science.gov (United States)

    Ciftlik, Ata Tuna; Ettori, Maxime; Gijs, Martin A M

    2013-08-26

    Matching the scale of microfluidic flow systems with that of microelectronic chips for realizing monolithically integrated systems still needs to be accomplished. However, this is appealing only if such re-scaling does not compromise the fluidic throughput. This is related to the fact that the cost of microelectronic circuits primarily depends on the layout footprint, while the performance of many microfluidic systems, like flow cytometers, is measured by the throughput. The simple operation of inertial particle focusing makes it a promising technique for use in such integrated flow cytometer applications, however, microfluidic footprints demonstrated so far preclude monolithic integration. Here, the scaling limits of throughput-per-footprint (TPFP) in using inertial focusing are explored by studying the interplay between theory, the effect of channel Reynolds numbers up to 1500 on focusing, the entry length for the laminar flow to develop, and pressure resistance of the microchannels. Inertial particle focusing is demonstrated with a TPFP up to 0.3 L/(min cm²) in high aspect-ratio rectangular microfluidic channels that are readily fabricated with a post-CMOS integratable process, suggesting at least a 100-fold improvement compared to previously demonstrated techniques. Not only can this be an enabling technology for realizing cost-effective monolithically integrated flow cytometry devices, but the methodology represented here can also open perspectives for miniaturization of many biomedical microfluidic applications requiring monolithic integration with microelectronics without compromising the throughput.

  16. Focus on Basics, 2001-2002.

    Science.gov (United States)

    Garner, Barbara, Ed.

    2002-01-01

    This volume of newsletters focuses on connecting research and practice in adult literacy programs. Issue A of August 2001 includes: "Techniques for Teaching Beginning-Level Reading to Adults" (Ashley Hager); "Beginning ESOL Learners' Advice to Their Teachers" (MaryAnn Cunningham Florez); "The Neurobiology of Reading and…

  17. Superintendent Leadership: Focusing on District Culture

    Science.gov (United States)

    Donnelly, Tanya A.; Adams, Jeffery S.; Smith, Dwayne E.

    2012-01-01

    This report describes a problem-based learning project focusing on superintendent leadership and stakeholder influence of school district culture. Current research findings suggest the importance of superintendent leadership in assessing, influencing, and enhancing school district culture. Multiple scholars wrote literature in the area of…

  18. Transformation media based super focusing antenna

    Energy Technology Data Exchange (ETDEWEB)

    Lu Wanli; Lin Zhifang [Surface Physics Laboratory, Department of Physics, Fudan University, Shanghai 200433 (China); Chen Huanyang [Department of Physics, Soochow University, Suzhou, Jiangsu 215006 (China); Chan, C T, E-mail: phlin@fudan.edu.c [Department of Physics and the William Mong Institute of NanoScience and Technology, The Hong Kong University of Science and Technology, Clear Water Bay (Hong Kong)

    2009-11-07

    We propose a new kind of focusing antenna with a large effective diameter based on transformation optics. The device contains a traditional parabolic antenna embedded in a dielectric core and coated by a negative index shell. Numerical simulations are performed to illustrate its advantages. (fast track communication)

  19. Optimization of focused ion beam performance

    NARCIS (Netherlands)

    Hagen, C.W.; Kruit, P.

    2009-01-01

    The authors have analyzed how much current can be obtained in the probe of an optimized two-lens focused ion beam (FIB) system. This becomes relevant, as systems become available that have the potential to image and/or fabricate structures smaller than 10 nm. The probe current versus probe size curv

  20. Spatial filters for focusing ultrasound images

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Gori, Paola

    2001-01-01

    . A new method for making spatial matched filter focusing of RF ultrasound data is proposed based on the spatial impulse response description of the imaging. The response from a scatterer at any given point in space relative to the transducer can be calculated, and this gives the spatial matched filter...

  1. Focused-ion-beam processing for photonics

    NARCIS (Netherlands)

    Ridder, de René M.; Hopman, Wico C.L.; Ay, Feridun

    2007-01-01

    Although focused ion beam (FIB) processing is a well-developed technology for many applications in electronics and physics, it has found limited application to photonics. Due to its very high spatial resolution in the order of 10 nm, and its ability to mill almost any material, it seems to have a go

  2. Superintendent Leadership: Focusing on District Culture

    Science.gov (United States)

    Donnelly, Tanya A.; Adams, Jeffery S.; Smith, Dwayne E.

    2012-01-01

    This report describes a problem-based learning project focusing on superintendent leadership and stakeholder influence of school district culture. Current research findings suggest the importance of superintendent leadership in assessing, influencing, and enhancing school district culture. Multiple scholars wrote literature in the area of…

  3. Trauma-Focused Training Program for Teachers

    Science.gov (United States)

    Davis, Marilyn Diane

    2016-01-01

    Teachers have reported that they have difficulty providing support to traumatized children and youth because of a lack of training in how to identify and respond to the needs of these children. The program, "Amazing Help Skills for Teachers to Unmask Trauma in Children and Youth" (AHSUM), is a trauma-focused training program, designed…

  4. Using Focus Groups to Clarify Customer Needs.

    Science.gov (United States)

    Sapp, Mary M.; Temares, M. Lewis

    1993-01-01

    Although traditional surveys are a valuable tool for college institutional researchers and others gathering data to support quality improvement programs, focus groups offer another technique for understanding university community members' needs and opinions by probing areas of special interest. University of Miami (Florida) experience illustrates…

  5. International Focus: Highlighting APPA Members Worldwide

    Science.gov (United States)

    Glazner, Steve, Comp.

    2011-01-01

    While most APPA member institutions are located in the United States and Canada, there are also 45 of member institutions located internationally--from Australia and New Zealand to Southeast Asia to the Middle East to Europe. This article focuses on four of its international members: (1) American University of Kuwait (AUK); (2) American University…

  6. Prosodic focus marking in Dali Mandarin

    NARCIS (Netherlands)

    Liu, L.Z.H.; van de Velde, H.; Chen, A.

    2016-01-01

    This study investigated prosodic marking of focus in Dali Mandarin, a variety of Xinan Guanhua (Southwestern Mandarin) spoken in Dali city, the capital of Dali Bai Autonomous Prefecture, China. Dali Mandarin as a variety of Mandarin has had heavy contact with Bai, a Tibeto-Burman language, for a lon

  7. Content-Focused Coaching: Five Key Practices

    Science.gov (United States)

    Gibbons, Lynsey K.; Cobb, Paul

    2016-01-01

    Many districts are using content-focused coaching as a strategy to provide job-embedded support to teachers. However, the current coaching literature provides little guidance on what coaches need to know and be able to do to engage teachers in activities that will support their development of ambitious instructional practices. Furthermore, little…

  8. Power Evaluation of Focused Cluster Tests.

    Science.gov (United States)

    Puett, Rc; Lawson, Ab; Clark, Ab; Hebert, Jr; Kulldorff, M

    2010-09-01

    Many statistical tests have been developed to assess the significance of clusters of disease located around known sources of environmental contaminants, also known as focused disease clusters. The majority of focused-cluster tests were designed to detect a particular spatial pattern of clustering, one in which the disease cluster centers around the pollution source and declines in a radial fashion with distance. However, other spatial patterns of environmentally related disease clusters are likely given that the spatial dispersion patterns of environmental contaminants, and thus human exposure, depend on a number of factors (i.e., meteorology and topography). For this study, data were simulated with five different spatial patterns of disease clusters, reflecting potential pollutant dispersion scenarios: 1) a radial effect decreasing with increasing distance, 2) a radial effect with a defined peak and decreasing with distance, 3) a simple angular effect, 4) an angular effect decreasing with increasing distance and 5) an angular effect with a defined peak and decreasing with distance. The power to detect each type of spatially distributed disease cluster was evaluated using Stone's Maximum Likelihood Ratio Test, Tango's Focused Test, Bithell's Linear Risk Score Test, and variations of the Lawson-Waller Score Test. Study findings underscore the importance of considering environmental contaminant dispersion patterns, particularly directional effects, with respect to focused-cluster test selection in cluster investigations. The effect of extra variation in risk also is considered, although its effect is not substantial in terms of the power of tests.

  9. Quadrupole Focusing Lenses for Charged Particles

    Energy Technology Data Exchange (ETDEWEB)

    Cork, Bruce; Zajec, Emery

    1953-04-15

    A set of four strong focusing magnetic quadrupole lenses has been constructed and operated. Each lens consists of four air cooled electromagnets with pole tips having a hyperbolic cross section. Each lens is 4 in. long and has an aperture 2 in. in diameter. Measurements of the magnetic field demonstrate that the hyperbolic cross section satisfies the requirements of a constant magnetic field gradient very well. The technique of deflecting a current carrying flexible wire has been used to measure the trajectory of charged particles through the system of lenses. It has been observed that the strong focusing requirements are satisfied. The system of lenses was then used to focus 0.5 Mev protons, 20 Mev deuterons, and 40 Mev alpha particles. The parallel beam of 0.5 Mev protons was detected by observing the incandescence of a quartz plate while the protons were bombarding it. The focused beam was less than 1 mm in diameter. The astigmatic 20 Mev deuteron beam from the 60 in. cyclotron was increased in current density by a factor greater than 30.

  10. A focused information criterion for graphical models

    NARCIS (Netherlands)

    Pircalabelu, E.; Claeskens, G.; Waldorp, L.

    2015-01-01

    A new method for model selection for Gaussian Bayesian networks and Markov networks, with extensions towards ancestral graphs, is constructed to have good mean squared error properties. The method is based on the focused information criterion, and offers the possibility of fitting individual-tailore

  11. Revitalize Electrical Program with Renewable Energy Focus

    Science.gov (United States)

    Karns, Robert J.

    2012-01-01

    Starting a renewable energy technology (RET) program can be as simple as shifting the teaching and learning focus of a traditional electricity program toward energy production and energy control systems. Redirecting curriculum content and delivery to address photovoltaic solar (PV solar) technology and small wind generation systems is a natural…

  12. Careers in focus library and information science

    CERN Document Server

    2011-01-01

    Careers in Focus: Library and Information Science, Second Edition profiles 19 careers for professionals interested in this field. Job profiles include:. -Acquisitions librarians. -Book conservators. -Children's librarians. -Corporate librarians. -Film and video librarians. -Law librarians. -Library assistants. -Library media specialists. -Medical librarians. -Research assistants.

  13. GRI: focusing on the evolving violent universe

    DEFF Research Database (Denmark)

    Knodlseder, J.; von Ballmoos, P.; Frontera, F.;

    2009-01-01

    The gamma-ray imager (GRI) is a novel mission concept that will provide an unprecedented sensitivity leap in the soft gamma-ray domain by using for the first time a focusing lens built of Laue diffracting crystals. The lens will cover an energy band from 200-1,300 keV with an effective area reach...... processes in the universe....

  14. Generating focused topic-specific sentiment lexicons

    NARCIS (Netherlands)

    Jijkoun, V.; de Rijke, M.; Weerkamp, W.

    2010-01-01

    We present a method for automatically generating focused and accurate topic-specific subjectivity lexicons from a general purpose polarity lexicon that allow users to pin-point subjective on-topic information in a set of relevant documents. We motivate the need for such lexicons in the field of medi

  15. Trauma-Focused Training Program for Teachers

    Science.gov (United States)

    Davis, Marilyn Diane

    2016-01-01

    Teachers have reported that they have difficulty providing support to traumatized children and youth because of a lack of training in how to identify and respond to the needs of these children. The program, "Amazing Help Skills for Teachers to Unmask Trauma in Children and Youth" (AHSUM), is a trauma-focused training program, designed…

  16. Revitalize Electrical Program with Renewable Energy Focus

    Science.gov (United States)

    Karns, Robert J.

    2012-01-01

    Starting a renewable energy technology (RET) program can be as simple as shifting the teaching and learning focus of a traditional electricity program toward energy production and energy control systems. Redirecting curriculum content and delivery to address photovoltaic solar (PV solar) technology and small wind generation systems is a natural…

  17. Introduction to focus issue: mesoscales in complex networks.

    Science.gov (United States)

    Almendral, Juan A; Criado, Regino; Leyva, Inmaculada; Buldú, Javier M; Sendiña-Nadal, Irene

    2011-03-01

    Although the functioning of real complex networks is greatly determined by modularity, the majority of articles have focused, until recently, on either their local scale structure or their macroscopical properties. However, neither of these descriptions can adequately describe the important features that complex networks exhibit due to their organization in modules. This Focus Issue precisely presents the state of the art on the study of complex networks at that intermediate level. The reader will find out why this mesoscale level has become an important topic of research through the latest advances carried out to improve our understanding of the dynamical behavior of modular networks. The contributions presented here have been chosen to cover, from different viewpoints, the many open questions in the field as different aspects of community definition and detection algorithms, moduli overlapping, dynamics on modular networks, interplay between scales, and applications to biological, social, and technological fields.

  18. A Simple Mechanism for Focused Web-harvesting

    CERN Document Server

    Akbar, Z

    2008-01-01

    The focused web-harvesting is deployed to realize an automated and comprehensive index databases as an alternative way for virtual topical data integration. The web-harvesting has been implemented and extended by not only specifying the targeted URLs, but also predefining human-edited harvesting parameters to improve the speed and accuracy. The harvesting parameter set comprises three main components. First, the depth-scale of being harvested final pages containing desired information counted from the first page at the targeted URLs. Secondly, the focus-point number to determine the exact box containing relevant information. Lastly, the combination of keywords to recognize encountered hyperlinks of relevant images or full-texts embedded in those final pages. All parameters are accessible and fully customizable for each target by the administrators of participating institutions over an integrated web interface. A real implementation to the Indonesian Scientific Index which covers all scientific information acr...

  19. The Focus-Background Articulation in Spanish Qualitative Binominal NPs

    Directory of Open Access Journals (Sweden)

    Xavier Villalba

    2008-12-01

    Full Text Available The goal of this article is to show that, unlike recent analyses of the qualitative binominal NP construction (QBNP that idiot of a doctor/el idiota del médico, Spanish QBNPs require an analysis with the following features: (i the definite article preceding the subject nominal is a fully-fledged determiner, (ii the predicate-subject final word order is the consequence of predicate focus fronting, (iii the subject receives background interpretation, and (iv as a consequence of its interpretation as background, the subject of the construction must be specific, which explains the apparently syntactic restrictions on the size of the nominals occurring in this position. This proposal is shown to extend straightforwardly to a kindred Spanish nominalizing construction, yielding a better understanding of the role of focus in DP structure.

  20. Study of a final focus system for high intensity beams

    Energy Technology Data Exchange (ETDEWEB)

    Henestroza, Enrique; Eylon, Shmuel; Roy, Prabir K.; Yu, Simon S.; Bieniosek, Frank M.; Shuman, Derek B.; Waldron, William L.

    2004-06-01

    The NTX experiment at the Heavy Ion Fusion Virtual National Laboratory is exploring the performance of neutralized final focus systems for high perveance heavy ion beams. The final focus scenario in an HIF driver consists of several large aperture quadrupole magnets followed by a drift section in which the beam space charge is neutralized by a plasma. This beam is required to hit a millimeter-sized target spot at the end of the drift section. The objective of the NTX experiments and associated theory and simulations is to study the various physical mechanisms that determine the final spot size (radius r{sub s}) at a given distance (f) from the end of the last quadrupole. In a fusion driver, f is the standoff distance required to keep the chamber wall and superconducting magnets properly protected. The NTX final quadrupole focusing system produces a converging beam at the entrance to the neutralized drift section where it focuses to a small spot. The final spot is determined by the conditions of the beam entering the quadrupole section, the beam dynamics in the magnetic lattice, and the plasma neutralization dynamics in the drift section. The main issues are the control of emittance growth due to high order fields from magnetic multipoles and image fields. In this paper, we will describe the theoretical and experimental aspects of the beam dynamics in the quadrupole lattice, and how these physical effects influence the final beam size. In particular, we present theoretical and experimental results on the dependence of final spot size on geometric aberrations and perveance.

  1. EDITORIAL: Focus on Heart and Mind

    Science.gov (United States)

    Bodenschatz, Eberhard; Wolf, Fred

    2008-01-01

    Among the organs of our body, the function of heart and brain are unique in that their operation emerges from the collective dynamics of millions of strongly interacting cells well organized in their geometrical structure and connectivity. In the heart muscle the propagation of a nonlinear wave pulse, the cardiac action potential, controls the contraction. Usually the propagation is well-organized both in space and time and the heart functions as an efficient biological pump. Instabilities triggered by diseased tissue but also by dynamical heterogeneities, may, however, induce cardiac arrhythmia and fibrillation, where the pacemaker looses control to dynamically generated, high-frequency self-excitation of the muscle. In this state the coherence of contraction is lost and may lead within minutes to death. The appearance of arrhythmias can be associated with topological singularities, the so called spiral or scroll waves, and how the occurrence of this malfunctioning pattern-formation process can be understood is a dominant subject of current research. This is all the more important as cardiac arrhythmias and fibrillation are the main cause of premature death in the developed world. Similarly, in the brain the propagation of a nonlinear wave pulse, namely the neural action potential, is at the basis of the computational and memory power of the brain, i.e. what determines the workings of our 'minds'. Here, however, due to the high degree of interconnectivity and topological complexity of the neuronal network, the coordinated activity of millions of interacting nerve cells is more complex, although the basic principles of action potential generation at the level of each cell are quite similar. The currently emerging field of network dynamical systems is largely driven by the mathematical challenge and the steady stream of novel dynamical phenomena that results from the interplay of local nonlinear dynamics and complex network structure in models of biological neuronal

  2. EDITORIAL: Focus issue on string cosmology Focus issue on string cosmology

    Science.gov (United States)

    Balasubramanian, V.; Moniz, P. R. L. V.

    2011-08-01

    String cosmology is a grand opportunity. The field involves elements of a promising framework, string theory, that brings together gravity and quantum mechanics and attempts to unify all the interactions. Confirming the concepts of string theory is presently beyond the reach of ground-based laboratories but the heavens may provide a setting for testing the string theoretic framework. Specifically, as cosmology develops into a rigorous, data-driven scientific discipline, windows into earlier epochs and higher energies are becoming available. If string theory controlled the evolution of the very early universe it is conceivable that it might have left imprints that are still detectable today. With this possibility in mind, this focus issue of Classical and Quantum Gravity appraises recent applications of string-theoretic and string-inspired ideas to the cosmos. The contents of this issue span the following areas: (1) Inflationary scenarios within different kinds of string-theoretic sectors (C P Burgess and L McAllister; M Cicoli and F Quevedo) (2) Alternatives to conventional inflation and dark matter/energy models with novel dynamics or matter content (J-L Lehners; M Trodden and K Hinterbichler) (3) Cosmic scenarios arising from the landscape of string vacua (M Kleban; B Freivogel) (4) Dynamical mechanisms determining the number of dimensions and resolving cosmic singularities (R H Brandenberger; B Craps and O Evnin) (5) Possible subsequent consequences of an early stringy phase (E J Copeland, L Pogosian and T Vachaspati; A Mazumdar) (6) Whether an observational `window' might be accessible (D J Mulryne and J Ward). The articles in this issue also survey a number of potentially promising directions for the future.

  3. Atomic focusing by quantum fields: Entanglement properties

    Energy Technology Data Exchange (ETDEWEB)

    Paz, I.G. da [Departamento de Física, Universidade Federal do Piauí, Campus Ministro Petrônio Portela, CEP 64049-550, Teresina, PI (Brazil); Frazão, H.M. [Universidade Federal do Piauí, Campus Profa. Cinobelina Elvas, CEP 64900-000, Bom Jesus, PI (Brazil); Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Caixa Postal 702, Belo Horizonte, MG 30123-970 (Brazil); Nemes, M.C. [Departamento de Física, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Caixa Postal 702, Belo Horizonte, MG 30123-970 (Brazil); Peixoto de Faria, J.G. [Departamento de Física e Matemática, Centro Federal de Educação Tecnológica de Minas Gerais, Av. Amazonas 7675, Belo Horizonte, MG 30510-000 (Brazil)

    2014-04-01

    The coherent manipulation of the atomic matter waves is of great interest both in science and technology. In order to study how an atom optic device alters the coherence of an atomic beam, we consider the quantum lens proposed by Averbukh et al. [1] to show the discrete nature of the electromagnetic field. We extend the analysis of this quantum lens to the study of another essentially quantum property present in the focusing process, i.e., the atom–field entanglement, and show how the initial atomic coherence and purity are affected by the entanglement. The dynamics of this process is obtained in closed form. We calculate the beam quality factor and the trace of the square of the reduced density matrix as a function of the average photon number in order to analyze the coherence and purity of the atomic beam during the focusing process.

  4. The stabilisation of final focus system

    Indian Academy of Sciences (India)

    P A Coe; D Urner; A Reichold

    2007-12-01

    The StaFF (stabilisation of final focus) system will use interferometers to monitor the relative positions and orientations of several key components in the beam-delivery and interaction region. Monitoring the relative positions of the ILC final focus quadrupole magnets will be the most demanding application, where mutual and beam-relative stability will have a direct impact on machine luminosity. Established, laser-based frequency scanning interferometry (FSI) and fixed-frequency interferometry (FFI) offer positional resolution at length scales of the laser wavelength (1500 nm to 1560 nm) and a thousandth of the wavelength, respectively. As part of the ATF at KEK, StaFF will use interferometers to measure lines of a geodetic network to record relative motion between two beam position monitors. Interferometers are being designed and tested in Oxford prior to deployment at the ATF.

  5. Self-focusing of whistler waves

    Science.gov (United States)

    Karpman, V. I.; Kaufman, R. N.; Shagalov, A. G.

    1992-01-01

    The theory of axially symmetric self-focusing of whistler waves, based on the full system of Maxwell equations, is developed. The plasma is described by the magnetohydrodynamic equations including the ponderomotive force from RF field. The nonlinear Schrodinger equations (NSE) for arbitrary azimuthal modes of whistler waves are derived. It is shown that they differ from the NSE for a scalar field; this is connected with an intrinsic angular momentum due to the rotating polarization of whistlers. It is shown that the self-focusing, as described by the NSE, differs in its final stage from the results following the full set of Maxwell equations. The latter gives defocusing after sufficient narrowing of the initial wave beam, due to transformation of the trapped wave into a nontrapped branch which is not contained in the NSE description. The oscillatory character of the defocusing is demonstrated.

  6. FOCUSING AND ACCELERATION OF BUNCHED BEAMS

    Energy Technology Data Exchange (ETDEWEB)

    PARSA,Z.; ZADOROZHNY,V.

    2000-04-07

    A new approach to solving the kinetic equation for the beam distribution function, (very useful from the practical point of view), is discussed, in which the authors also obtain a complement to the Skrinsky's condition for the self-focused bunched beam. This problem belongs to the theory of nonlinear systems in which both regular and chaotic motion is possible. The kinetic approach, based on Vlasov-Poisson equations, are used to investigate the focusing and acceleration of bunched beam. Special attention is given to the studies of stability in a bunched beam by means of the two norm, which may be used to describe t!he motion of high-energy particles.

  7. Focus on biodiversity, health and wellbeing

    Science.gov (United States)

    Stephens, Carolyn; Athias, Renato

    2015-12-01

    In 2012 Environmental Research Letters (ERL) launched a focus series of research papers on the theme of biodiversity, health and well-being. It was the year of the second Rio Summit on Sustainable Development, a huge number of species had been made extinct and conservationists were making increasingly urgent calls for the protection of biodiversity. The situation is ever more critical. Since we started the issue more species have become extinct, and hundreds more have now become critically endangered. The focus issue highlighted the complexity of the links of biodiversity and health, and provides more evidence for the importance to human health of biodiversity on our planet. Research papers contrasted anthropocentric western scientific views of biodiversity and its ecosystem service to humans, with the more horizontal conceptions of indigenous communities in the Amazon—and as many cultures have recognized throughout history, they recognize that we are part of nature: nature does not exist for us.

  8. Konseling Pancawaskita untuk Membentuk Problem Focused Coping

    Directory of Open Access Journals (Sweden)

    Eko Sujadi

    2015-11-01

    Full Text Available Problem focused coping with needs to be owned by any individual. When in a stressful situation, individuals are oriented in this strategy will seek to address and eliminate the less pleasant atmosphere directly to sources of stress through concrete actions that are positive. The emergence of the stress on the individual factors within or due to the influence of outside forces. Through pancawaskita counseling of individuals need to be aware that he has the power of all of that can be utilized to achieve a life of happiness. Execution of counseling by counselors in pancawaskita form the problem focused coping must be accompanied by a performance and spirit accompanied with intelligence, strength, precision, “keterarahan”, and “kearifbijaksanaan”.

  9. Targeting the Tumor Microenvironment: Focus on Angiogenesis

    Directory of Open Access Journals (Sweden)

    Fengjuan Fan

    2012-01-01

    Full Text Available Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established. Research on angiogenesis in general, and vascular endothelial growth factor in particular, is a major focus in biomedicine and has led to the clinical approval of several antiangiogenic agents including thalidomide, bevacizumab, sorafenib, sunitinib, pazopanib, temesirolimus, and everolimus. Indeed, antiangiogenic agents have significantly changed treatment strategies in solid tumors (colorectal cancer, renal cell carcinoma, and breast cancer and multiple myeloma. Here we illustrate important aspects in the interrelationship between tumor cells and the microenvironment leading to tumor progression, with focus on angiogenesis, and summarize derived targeted therapies.

  10. Targeting the tumor microenvironment: focus on angiogenesis.

    Science.gov (United States)

    Fan, Fengjuan; Schimming, Alexander; Jaeger, Dirk; Podar, Klaus

    2012-01-01

    Tumorigenesis is a complex multistep process involving not only genetic and epigenetic changes in the tumor cell but also selective supportive conditions of the deregulated tumor microenvironment. One key compartment of the microenvironment is the vascular niche. The role of angiogenesis in solid tumors but also in hematologic malignancies is now well established. Research on angiogenesis in general, and vascular endothelial growth factor in particular, is a major focus in biomedicine and has led to the clinical approval of several antiangiogenic agents including thalidomide, bevacizumab, sorafenib, sunitinib, pazopanib, temesirolimus, and everolimus. Indeed, antiangiogenic agents have significantly changed treatment strategies in solid tumors (colorectal cancer, renal cell carcinoma, and breast cancer) and multiple myeloma. Here we illustrate important aspects in the interrelationship between tumor cells and the microenvironment leading to tumor progression, with focus on angiogenesis, and summarize derived targeted therapies.

  11. Gravitational focusing of imperfect dark matter

    Science.gov (United States)

    Babichev, Eugeny; Ramazanov, Sabir

    2017-01-01

    Motivated by the projectable Horava-Lifshitz model/mimetic matter scenario, we consider a particular modification of standard gravity, which manifests as an imperfect low pressure fluid. While practically indistinguishable from a collection of nonrelativistic weakly interacting particles on cosmological scales, it leaves drastically different signatures in the Solar system. The main effect stems from gravitational focusing of the flow of imperfect dark matter passing near the Sun. This entails strong amplification of imperfect dark matter energy density compared to its average value in the surrounding halo. The enhancement is many orders of magnitude larger than in the case of cold dark matter, provoking deviations of the metric in the second order in the Newtonian potential. Effects of gravitational focusing are prominent enough to substantially affect the planetary dynamics. Using the existing bound on the post-Newtonian parameter βPPN, we deduce a stringent constraint on the unique constant of the model.

  12. NEESPI focus issues in Environmental Research Letters

    Science.gov (United States)

    Norman, Julian; Groisman, Pavel; Soja, Amber J.

    2010-05-01

    In 2007 and 2009 Environmental Research Letters published focus issues (edited by Pavel Groisman and Amber J Soja) made up of work carried out by NEESPI participants. Here, we present the content of those focus issues as an invaluable resource for researchers working in the NEESPI study area. The first of the two issues, published in 2007 with title 'Northern Hemisphere High Latitude Climate and Environmental Change', presents a diverse collection of articles that are assembled into five groups devoted to studies of climate and hydrology, land cover and land use, the biogeochemical cycle and its feedbacks, the cryosphere, and human dimensions. The second issue, published in 2009, with title 'Climatic and Environmental Change in Northern Eurasia' presents diverse, assorted studies of different aspects of contemporary change, representing the diversity of climates and ecosystems across Northern Eurasia.

  13. Gravitational focusing of Imperfect Dark Matter

    CERN Document Server

    Babichev, Eugeny

    2016-01-01

    Motivated by the projectable Horava-Lifshitz model/mimetic matter scenario, we consider a particular modification of standard gravity, which manifests as an imperfect low pressure fluid. While practically indistinguishable from collection of non-relativistic weakly interacting particles on cosmological scales, it leaves drastically different signatures in the Solar system. The main effect stems from gravitational focusing of the flow of {\\it Imperfect Dark Matter} passing near the Sun. This entails the strong amplification of Imperfect Dark Matter energy density compared to its average value in the surrounding halo. The enhancement is many orders of magnitude larger than in the case of Cold Dark Matter, provoking deviations of the metric in the second order in the Newtonian potential. Effects of gravitational focusing are prominent enough to substantially affect the planetary dynamics. Using the existing bound on the PPN parameter $\\beta_{PPN}$, we deduce the stringent constraint on the unique constant of the...

  14. Mixed waste characterization, treatment & disposal focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    The mission of the Mixed Waste Characterization, Treatment, and Disposal Focus Area (referred to as the Mixed Waste Focus Area or MWFA) is to provide treatment systems capable of treating DOE`s mixed waste in partnership with users, and with continual participation of stakeholders, tribal governments, and regulators. The MWFA deals with the problem of eliminating mixed waste from current and future storage in the DOE complex. Mixed waste is waste that contains both hazardous chemical components, subject to the requirements of the Resource Conservation and Recovery Act (RCRA), and radioactive components, subject to the requirements of the Atomic Energy Act. The radioactive components include transuranic (TRU) and low-level waste (LLW). TRU waste primarily comes from the reprocessing of spent fuel and the use of plutonium in the fabrication of nuclear weapons. LLW includes radioactive waste other than uranium mill tailings, TRU, and high-level waste, including spent fuel.

  15. SCIENTIFIC COMMUNICATION WITH A FOCUS ON SESAME

    CERN Document Server

    ahmad, sameem

    2017-01-01

    Scientific communication, the representation of CERN and raising awareness about science to a wide range of audiences is very important for the CERN communication teams. Having a physics background and an interest in science administration, communication and research, I was based in the International Relations sector, working in various groups and focusing on written communication. I gained experience in many aspects of scientific communications by finding out how CERN in represented in the press and media, other online forums and in outreach.

  16. Temperature Measurements of an Implosion Focus

    Science.gov (United States)

    1981-07-01

    emissivity can also be evaluated from the values at the intersection of the line with the vertical axis. However, after evaluating Implosion-.Focus...Ref. 11. S. COMPARISON OP EXPERIMENTAL RESULTS AND THEORY Figure 5 compares the experimental results and the expected average tom- iI 13121 Salto et a1...ahead of the shock front, even though the imploding shock wave continued to conveo’ge. A high degree of I 13141 Salto et al. convergence was obtained

  17. Presentational Focus in Heritage and Monolingual Spanish

    Science.gov (United States)

    Hoot, Bradley

    2012-01-01

    In Spanish, it is most commonly claimed that constituents in narrow presentational focus appear rightmost, where they also get main stress (1a), while stress in situ (1b) is infelicitous. (1) [Context: Who bought a car?]. a. Compró un carro mi [mamá][subscript F]. bought a car my mom. b. Mi [mamá ][subscript F] compró un carro. However, some…

  18. Focusing magnets for HIF based on racetracks

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N N; Manahan, R R

    2000-09-11

    Heavy Ion Fusion (HIF) is considered a promising path to a practical fusion reactor. A driver for a HIF reactor will require a large number of quadrupole arrays to focus heavy ion beams. A conceptual design, and trade off studies of the quadrupole array based on racetracks are presented. A comparison with a conventional shell magnet is given and advantages and disadvantages are discussed. A more detailed design of a single quadrupole for the High Current experiment (HCX) is presented and discussed.

  19. Service Academy 2009 Gender Relations Focus Groups

    Science.gov (United States)

    2009-09-01

    Stebbins (Department of Defense [DoD] Sexual Assault Prevention and Response Office); COL Jeannette McMahon (U.S. Military Academy [USMA]); CAPT Diana...keep that private. However, once you go from a private to this open line you can’t go back.” (Male) Choosing Restricted or Unrestricted Reporting...Focus group participants indicated there are several avenues for reporting stalking. – “You can go up through the TAC [Tactical Officer] line and go

  20. Vision Trainer Teaches Focusing Techniques at Home

    Science.gov (United States)

    2015-01-01

    Based on work Stanford Research Institute did for Ames Research Center, Joseph Trachtman developed a vision trainer to treat visual focusing problems in the 1980s. In 2014, Trachtman, operating out of Seattle, released a home version of the device called the Zone-Trac. The inventor has found the biofeedback process used by the technology induces an alpha-wave brain state, causing increased hand-eye coordination and reaction times, among other effects

  1. Epileptogenic focus localization: a new approach

    Energy Technology Data Exchange (ETDEWEB)

    Tavares, Vânia [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa (Portugal); Ribeiro, André Santos [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa (Portugal); Centre for Neuropsychopharmacology, Division of Brain Sciences, Department of Medicine, Imperial College London, London (United Kingdom); Capela, Carlos; Cerqueira, Luís [Department of Neuroradiology, Centro Hospitalar Lisboa Central, Lisbon (Portugal); Ferreira, Hugo Alexandre [Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisboa (Portugal)

    2015-05-18

    Epilepsy is one of the most important chronic neurological disorders worldwide affecting more than 50 million people of all ages. Among these, almost 20% of epilepsy cases are uncontrollable and have an unknown source of this abnormal electrical activity. Present techniques for the detection of epileptogenic foci include electroencephalography (EEG), positron emission tomography, and multimodal EEG/functional magnetic resonance imaging (fMRI), all with limitations in terms of spatial and temporal resolutions. In order to overcome some of those limitations a novel approach using fMRI alone was developed based on the hypotheses that the epileptogenic focus shows Blood Oxygen Level Dependent (BOLD) temporal profiles distinct from the remaining brain parenchyma during interictal activity and that the epileptogenic focus BOLD signals show lower complexity than healthy parenchyma. In this novel approach, bi-dimensional temporal clustering analysis, a data-driven technique, was used to identify brain regions with similar temporal profiles. Then, the BOLD signals of these regions were assessed regarding complexity using detrended fluctuation analysis and also using a modified multiscale entropy algorithm in order to identify which of those regions corresponded to epileptogenic tissue. In order to demonstrate the applicability of the developed method three epileptic patients were analyzed comprising two types of epilepsy: unilateral and bilateral temporal lobe epilepsies. The results showed that this method is able to detect the brain regions associated with epileptogenic tissue. The results also showed that the epileptogenic focus influences the dynamics of related brain networks. This could be a key factor in the applicability of this method to other epilepsy cases. Finally, new perspectives are envisioned concerning the use of this method in the medical care of epilepsy. In particular, by improving this method using simultaneous structural, functional, and metabolic

  2. Photoacoustic cell using elliptical acoustic focusing

    Science.gov (United States)

    Heritier, J.-M.; Fouquet, J. E.; Siegman, A. E.

    1982-01-01

    A photoacoustic cell has been developed in the form of an elliptical cylinder in which essentially all the acoustic energy generated by a laser beam passing down one axis is focused onto a cylindrical acoustic tranducer located along the other axis. Preliminary measurements on a liquid-filled cell of this design show high sensitivity and a notably clean impulse response. A similar design may be useful for photoacoustic measurements in vapors as well.

  3. Results of Final Focus Test Beam

    Energy Technology Data Exchange (ETDEWEB)

    Walz, Dieter R

    2003-06-13

    The beam experiments of Final Focus Test Beam (FFTB) started in September 1993 at SLAC, and have produced a 1.7 {micro}m x 75 nm spot of 46 GeV electron beam. A number of new techniques involving two nanometer spot-size monitors have been developed. Several beam diagnostic/tuning schemes are applied to achieve and maintain the small spot. This experiment opens the way toward the nanometer world for future linear colliders.

  4. Project Management with IT Security Focus

    Directory of Open Access Journals (Sweden)

    Felician Alecu

    2011-12-01

    Full Text Available The paper focus on the main key points related to the IT security project management. The most important lifecycle stages are identified: IT security project proposal definition, project organization, project planning, quality planning, project team organization, IT security project activities management and project closing. The most important success factors for IT security projects are the support of top-management, customer satisfaction, prevention over remediation and continuous progress. Also, the project manger skills are highlighted in this specific context.

  5. Tunable Focusing by a Flexible Metasurface

    CERN Document Server

    Zárate, Yair; Powell, David A

    2016-01-01

    An efficient reflective elastic metasurface with tunable focusing point is proposed. The metasurface is based on electric resonators embedded in a stretchable elastic substrate. The focal length is controlled by mean of the stretching applied applied to the sample. The results predicted by theory and numerical simulations are experimentally verified. Our proposal shows that smart engineering elastic metamaterials are an effective platform for new functional devices based on metamaterials.

  6. Focus on thermoelectric effects in nanostructures

    Science.gov (United States)

    Sánchez, David; Linke, Heiner

    2014-11-01

    The field of nanoscale thermoelectrics began with a clear motivation for better performances of waste heat recovery processes by lowering the system dimensionality. Although this original inspiration still drives many recent developments, the field has also evolved to address fundamental questions on charge and energy transport across quantum conductors in the presence of both voltage and temperature differences. This ‘focus on’ collection provides new perspectives in the field and reports on the latest developments, both theoretically and experimentally.

  7. Introduction to Focus Issue: Lagrangian Coherent Structures.

    Science.gov (United States)

    Peacock, Thomas; Dabiri, John

    2010-03-01

    The topic of Lagrangian coherent structures (LCS) has been a rapidly growing area of research in nonlinear dynamics for almost a decade. It provides a means to rigorously define and detect transport barriers in dynamical systems with arbitrary time dependence and has a wealth of applications, particularly to fluid flow problems. Here, we give a short introduction to the topic of LCS and review the new work presented in this Focus Issue.

  8. Inertial focusing of microparticles and its limitations

    Science.gov (United States)

    Cruz, FJ; Hooshmand Zadeh, S.; Wu, ZG; Hjort, K.

    2016-10-01

    Microfluidic devices are useful tools for healthcare, biological and chemical analysis and materials synthesis amongst fields that can benefit from the unique physics of these systems. In this paper we studied inertial focusing as a tool for hydrodynamic sorting of particles by size. Theory and experimental results are provided as a background for a discussion on how to extend the technology to submicron particles. Different geometries and dimensions of microchannels were designed and simulation data was compared to the experimental results.

  9. Surmounting the Myopic Focus on Genocide

    DEFF Research Database (Denmark)

    Nielsen, Christian Axboe

    2013-01-01

    and counterproductive approach to the analysis of mass violence. Discussions revolving around a ‘genocide or not’ dichotomy do not further our understanding of the Bosnian war, and are in their essence more connected to desires for past and future international military interventions and to internal Bosnian political...... relations within the Bosniak community. Ultimately, therefore, it may be more productive to move beyond what has become a myopic focus on genocide....

  10. Seven Issues Should Be Focused on Investment

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ According to the investment situation of the first half of this year, under macro-control of the central government, the super high-speed investment momentum in the first half of this year was controlled and some overheated industries were becoming normal. Influenced by many positive factors, the targets of macro-control as expected will be achieved. However, in order to further settle this policy and realize the economic soft-landing, the following seven issues should be focused on.

  11. Magnetoresistive flux focusing eddy current flaw detection

    Science.gov (United States)

    Wincheski, Russell A. (Inventor); Namkung, Min (Inventor); Simpson, John W. (Inventor)

    2005-01-01

    A giant magnetoresistive flux focusing eddy current device effectively detects deep flaws in thick multilayer conductive materials. The probe uses an excitation coil to induce eddy currents in conducting material perpendicularly oriented to the coil's longitudinal axis. A giant magnetoresistive (GMR) sensor, surrounded by the excitation coil, is used to detect generated fields. Between the excitation coil and GMR sensor is a highly permeable flux focusing lens which magnetically separates the GMR sensor and excitation coil and produces high flux density at the outer edge of the GMR sensor. The use of feedback inside the flux focusing lens enables complete cancellation of the leakage fields at the GMR sensor location and biasing of the GMR sensor to a location of high magnetic field sensitivity. In an alternate embodiment, a permanent magnet is positioned adjacent to the GMR sensor to accomplish the biasing. Experimental results have demonstrated identification of flaws up to 1 cm deep in aluminum alloy structures. To detect deep flaws about circular fasteners or inhomogeneities in thick multilayer conductive materials, the device is mounted in a hand-held rotating probe assembly that is connected to a computer for system control, data acquisition, processing and storage.

  12. Inertial Focusing of Microparticles in Curvilinear Microchannels

    Science.gov (United States)

    Özbey, Arzu; Karimzadehkhouei, Mehrdad; Akgönül, Sarp; Gozuacik, Devrim; Koşar, Ali

    2016-12-01

    A passive, continuous and size-dependent focusing technique enabled by “inertial microfluidics”, which takes advantage of hydrodynamic forces, is implemented in this study to focus microparticles. The objective is to analyse the decoupling effects of inertial forces and Dean drag forces on microparticles of different sizes in curvilinear microchannels with inner radius of 800 μm and curvature angle of 280°, which have not been considered in the literature related to inertial microfluidics. This fundamental approach gives insight into the underlying physics of particle dynamics and offers continuous, high-throughput, label-free and parallelizable size-based particle separation. Our design allows the same footprint to be occupied as straight channels, which makes parallelization possible with optical detection integration. This feature is also useful for ultrahigh-throughput applications such as flow cytometers with the advantages of reduced cost and size. The focusing behaviour of 20, 15 and 10 μm fluorescent polystyrene microparticles was examined for different channel Reynolds numbers. Lateral and vertical particle migrations and the equilibrium positions of these particles were investigated in detail, which may lead to the design of novel microfluidic devices with high efficiency and high throughput for particle separation, rapid detection and diagnosis of circulating tumour cells with reduced cost.

  13. Focused Crawler Optimization Using Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Hartanto Kusuma Wardana

    2011-12-01

    Full Text Available As the size of the Web continues to grow, searching it for useful information has become more difficult. Focused crawler intends to explore the Web conform to a specific topic. This paper discusses the problems caused by local searching algorithms. Crawler can be trapped within a limited Web community and overlook suitable Web pages outside its track. A genetic algorithm as a global searching algorithm is modified to address the problems. The genetic algorithm is used to optimize Web crawling and to select more suitable Web pages to be fetched by the crawler. Several evaluation experiments are conducted to examine the effectiveness of the approach. The crawler delivers collections consist of 3396 Web pages from 5390 links which had been visited, or filtering rate of Roulette-Wheel selection at 63% and precision level at 93% in 5 different categories. The result showed that the utilization of genetic algorithm had empowered focused crawler to traverse the Web comprehensively, despite it relatively small collections. Furthermore, it brought up a great potential for building an exemplary collections compared to traditional focused crawling methods.

  14. What Are the Effects of Implementing Learning-Focused Strategies in Biology and Physical Science Classrooms?

    Science.gov (United States)

    Simmons, Robin

    2013-01-01

    The objective of this study was to determine if Learning-Focused Strategies (LFS) implemented in high school science courses would affect student achievement and the pass rate of biology and physical science Common District Assessments (CDAs). The LFS, specific teaching strategies contained in the Learning-Focused Strategies Model (LFSM) Program…

  15. How Many Focus Groups Are Enough? Building an Evidence Base for Nonprobability Sample Sizes

    Science.gov (United States)

    Guest, Greg; Namey, Emily; McKenna, Kevin

    2017-01-01

    Few empirical studies exist to guide researchers in determining the number of focus groups necessary for a research study. The analyses described here provide foundational evidence to help researchers in this regard. We conducted a thematic analysis of 40 focus groups on health-seeking behaviors of African American men in Durham, North Carolina.…

  16. New Research Findings on Emotionally Focused Therapy: Introduction to Special Section

    Science.gov (United States)

    Johnson, Susan M.; Wittenborn, Andrea K.

    2012-01-01

    This article introduces the special section "New Research Findings on Emotionally Focused Therapy." Emotionally focused couple therapy researchers have a strong tradition of outcome and process research and this special section presents new findings from three recent studies. The first study furthers the goal of determining the kinds of clients…

  17. What Are the Effects of Implementing Learning-Focused Strategies in Biology and Physical Science Classrooms?

    Science.gov (United States)

    Simmons, Robin

    2013-01-01

    The objective of this study was to determine if Learning-Focused Strategies (LFS) implemented in high school science courses would affect student achievement and the pass rate of biology and physical science Common District Assessments (CDAs). The LFS, specific teaching strategies contained in the Learning-Focused Strategies Model (LFSM) Program…

  18. Corporate philanthropic responses to emergent human needs: the role of organizational attention focus

    NARCIS (Netherlands)

    Muller, A.; Whiteman, G.

    2015-01-01

    Research on corporate philanthropy typically focuses on organization-external pressures and aggregated donation behavior. Hence, our understanding of the organization-internal structures that determine whether a given organization will respond philanthropically to a specific human need remains under

  19. Corporate philanthropic responses to emergent human needs: the role of organizational attention focus

    NARCIS (Netherlands)

    Muller, A.; Whiteman, G.

    2015-01-01

    Research on corporate philanthropy typically focuses on organization-external pressures and aggregated donation behavior. Hence, our understanding of the organization-internal structures that determine whether a given organization will respond philanthropically to a specific human need remains

  20. Finding focus : a study of the historical development of focus in English

    NARCIS (Netherlands)

    Komen, E.R.

    2013-01-01

    This study reveals how two important focus articulations change over time in written English. Constituent focus, often accompanied by contrast, makes use of the clause-initial position in the oldest stages of English, but as this position comes to be used for the grammatical subject over time, the i

  1. Field analysis of two-dimensional focusing grating

    OpenAIRE

    Borsboom, P.P.; Frankena, H.J.

    1995-01-01

    The method that we have developed [P-P. Borsboom, Ph.D. dissertation (Delft University of Technology, Delft, The Netherlands); P-P. Borsboom and H. J. Frankena, J. Opt. Soc. Am. A 12, 1134–1141 (1995)] is successfully applied to a two-dimensional focusing grating coupler. The field in the focal region has been determined for symmetrical chirped gratings consisting of as many as 124 corrugations. The intensity distribution in the focal region agrees well with the approximate predictions of geo...

  2. Topic-Focus Articulation of Isotopy

    Directory of Open Access Journals (Sweden)

    Radim Sova

    2012-09-01

    Full Text Available The paper deals with linguistic phenomena at suprasentential level. In particular, it looks into how textual analysis can be enhanced by supplementing the Parisian programme of interpretive semantics, as devised by François Rastier, namely his theory of isotopies, with elementary aspects of topic-focus articulation (TFA, as well as contextual boundness (CB and contextual non-boundness (CN, as elaborated within the Praguian linguistic tradition (V. Mathesius, P. Sgall, E. Hajičová, F. Daneš, J. Firbas, and how the descriptive power of the former can be increased by the latter. In this respect, it is argued that two types of TFA phenomena interact during any process of textual interpretation: those of topic-focus articulation at the level of sentence, conceiving lexical morphs as thematic (T and/or rhematic (R, as well as contextually bound (CB and/or contextually non-bound (CN, and those of topic-focus articulation at the level of isotopy, with each isotopy being conceived as structured around a center (an abstract semantic unit and periphery (a span of concrete utterances. Two types of such interaction are described, each defined by either correlation, or non-correlation of the CB and CN semes at the levels of isotopy and sentence, respectively: thematic-rhematic isotopy, induced by co-occurrence of the CB seme of the center and the CB seme of the periphery; and thematic-rhematic allotopy (i.e. non-isotopy, induced by co-occurrence of the CB seme of the center and the CN seme of the periphery. Since topic-focus isotopies and allotopies can be perceived as members of privative oppositions, a tentative system of such oppositions is presented, based on linguistic analyses of selected European Commission texts drafted in English and their Czech translations. The author’s ultimate intention is to show that the semantic features of topic-focus articulation at the sentential and suprasentential levels are both structurally parallel and

  3. Theoretical Study of a Spherical Plasma Focus

    Science.gov (United States)

    Ay, Yasar

    A theoretical model is developed for two concentric electrodes spherical plasma focus device in order to investigate the plasma sheath dynamics, radiative emission, and the ion properties. The work focuses on the model development of the plasma sheath dynamics and its validation, followed by studying of the radiation effects and the beam-ion properties in such unique geometry as a pulsed source for neutrons, soft and hard x-rays, and electron and ion beams. Chapter 1 is an introduction on fusion systems including plasma focus. Chapter 2 is an extensive literature survey on plasma focus modeling and experiments including the various radiations and their mechanism. Chapter 3 details modeling and validation of the plasma sheath dynamics model with comparison between hydrogen, deuterium, tritium and deuterium-tritium mixture for the production of pulsed neutrons. Chapter 4 is a study of the radiative phase, in which neutron yield is investigated, as well as the predicted beam-ion properties. Chapter 5 summarizes and discusses the results. Chapter 6 provides concluding remarks and proposed future works. The phases of the developed model are the rundown phase I, rundown phase II, the reflected phase and a radiative phase. The rundown phase I starts immediately after the completion of the gas breakdown and ends when the current sheath reaches the equator point of the spherical shape. Then immediately followed by rundown phase II to start and it ends when the shock front hits the axis, which is the beginning of the reflected shock phase. Reflected shock front moves towards the incoming current sheath and meets it which is both the end of the reflected shock phase and the beginning of the radiative phase. After the reflected shock front and the current sheath meet, the current sheath continues to move radially inward by compressing the produced plasma column until it reaches the axis. Since the discharge current contains important information about the plasma dynamic

  4. Plant Sex Determination.

    Science.gov (United States)

    Pannell, John R

    2017-03-06

    Sex determination is as important for the fitness of plants as it is for animals, but its mechanisms appear to vary much more among plants than among animals, and the expression of gender in plants differs in important respects from that in most animals. In this Minireview, I provide an overview of the broad variety of ways in which plants determine sex. I suggest that several important peculiarities of plant sex determination can be understood by recognising that: plants show an alternation of generations between sporophytic and gametophytic phases (either of which may take control of sex determination); plants are modular in structure and lack a germ line (allowing for a quantitative expression of gender that is not common in animals); and separate sexes in plants have ultimately evolved from hermaphroditic ancestors. Most theorising about sex determination in plants has focused on dioecious species, but we have much to learn from monecious or hermaphroditic species, where sex is determined at the level of modules, tissues or cells. Because of the fundamental modularity of plant development and potentially important evolutionary links between monoecy and dioecy, it may be useful to relax the distinction often made between 'developmental sex determination' (which underpins the development of male versus female flowers in monoecious species) and 'genetic sex determination' (which underpins the separation of males and females in dioecious species, often mediated by a genetic polymorphism and sex chromosomes). I also argue for relaxing the distinction between sex determination involving a genetic polymorphism and that involving responses to environmental or hormonal cues, because non-genetic cues might easily be converted into genetic switches.

  5. Neuroticism focuses attention: evidence from SSVEPs.

    Science.gov (United States)

    Dhinakaran, Janani; De Vos, Maarten; Thorne, Jeremy D; Kranczioch, Cornelia

    2014-06-01

    Neuroticism and negative affect have been associated with an increase in attentional investment and the greater processing of irrelevant stimuli. Previous research proposes the overinvestment of attention and a focused mental state as the mechanism of this effect. We investigated the neural correlates of this idea using a dual-stream rapid serial visual presentation paradigm with centrally presented, overlapping streams of letters that changed at different frequencies. Participants attended one stream at a time. We predicted that the more focused cognitive style associated with higher neuroticism would be reflected in the overinvestment of attention in the irrelevant stream of to-be-ignored letters, in particular, when the ignored stream was the more salient one. This was expected to lead to a smaller difference in power between the attended and unattended frequencies. Results showed that power differences between attended and unattended streams were negatively correlated with neuroticism scores in direct support of our hypothesis. Exploratory correlations also showed that extraversion was positively related to the attention difference. As extraversion has been contrasted to neuroticism and linked to increased cognitive flexibility and control in previous studies, it is possible that this trait may help in disengagement from salient stimuli. Together, these results provide the first neural correlates of the focused cognitive style idea. That the effect of extraversion is seen in the centro-parietal region and the effect of neuroticism is seen in the occipital region, indicate that these personality traits may affect the hierarchy of visual information processing. These findings provide new insight into the influence of personality traits on attention mechanisms and open up questions regarding the relationship between neuroticism, extraversion and information processing.

  6. Preliminary Results Of A 600 Joules Small Plasma Focus Device

    Science.gov (United States)

    Lee, S. H.; Yap, S. L.; Wong, C. S.

    2009-07-01

    Preliminary results of a 600 J (3.7 μF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0±0.5 μbar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.

  7. Nanostructuring superconducting vortex matter with focused ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Guillamón, I. [Laboratorio de Bajas Temperaturas, Departamento de Física de la Materia Condensada, Instituto de Ciencia de Materiales Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28049 Madrid (Spain); Unidad Asociada de Bajas Temperaturas y Altos Campos Magnéticos, UAM, CSIC, Cantoblanco, E-28049 Madrid (Spain); Suderow, H., E-mail: hermann.suderow@uam.es [Laboratorio de Bajas Temperaturas, Departamento de Física de la Materia Condensada, Instituto de Ciencia de Materiales Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28049 Madrid (Spain); Unidad Asociada de Bajas Temperaturas y Altos Campos Magnéticos, UAM, CSIC, Cantoblanco, E-28049 Madrid (Spain); Kulkarni, P.; Vieira, S. [Laboratorio de Bajas Temperaturas, Departamento de Física de la Materia Condensada, Instituto de Ciencia de Materiales Nicolás Cabrera, Facultad de Ciencias, Universidad Autónoma de Madrid, E-28049 Madrid (Spain); Unidad Asociada de Bajas Temperaturas y Altos Campos Magnéticos, UAM, CSIC, Cantoblanco, E-28049 Madrid (Spain); Córdoba, R.; Sesé, J. [Laboratorio de Microscopías Avanzadas (LMA) – Instituto de Nanociencia de Aragón (INA), Universidad de Zaragoza, Zaragoza 50009 (Spain); Departamento de Física de la Materia Condensada, Universidad de Zaragoza, 50009 Zaragoza (Spain); and others

    2014-08-15

    Highlights: • Nanostructuring vortex matter with focused ion beams. • Nanofabrication produces high vortex density gradients. • Patterning gives nanocrystalline vortex lattice. - Abstract: Focused ion beams provide new opportunities to create small nanofabricated structures. Materials where this technique is successfully applied are different from those that are widely used in e-beam or photolithography processes. Arrays of holes have been fabricated in several layered superconductors, such as the transition metal dichalcogenides. A focused ion beam system can be also used to deposit superconducting material. A Ga beam is used to decompose a precusor W(CO){sub 6} molecule, giving an amorphous mixture of W–C–Ga–O which is superconducting below liquid helium temperatures. The amorphous nature of the deposit gives isotropic superconducting features, and vortex pinning is determined by the surface topography (or film thickness). Here we present vortex lattice images in an amorphous thin film with a nanofabricated array of dots. We find vortex confinement within the dots and inhomogeneous vortex distributions with large magnetic field gradients (around a Tesla in 10–20 nm). We discuss scaling behavior of the vortex lattice after nanofabrication.

  8. Focused Ion Beam Technology for Optoelectronic Devices

    Science.gov (United States)

    Reithmaier, J. P.; Bach, L.; Forchel, A.

    2003-08-01

    High-resolution proximity free lithography was developed using InP as anorganic resist for ion beam exposure. InP is very sensitive on ion beam irradiation and show a highly nonlinear dose dependence with a contrast function comparable to organic electron beam resists. In combination with implantation induced quantum well intermixing this new lithographic technique based on focused ion beams is used to realize high performance nano patterned optoelectronic devices like complex coupled distributed feedback (DFB) and distributed Bragg reflector (DBR) lasers.

  9. Triplet Focusing for Recirculating Linear Muon Accelerators

    CERN Document Server

    Keil, Eberhard

    2001-01-01

    Focusing by symmetrical triplets is studied for the linear accelerator lattices in recirculating muon accelerators with several passes where the ratio of final to initial muon energy is about four. Triplet and FODO lattices are compared. At similar acceptance, triplet lattices have straight sections for the RF cavities that are about twice as long as in FODO lat-tices. For the same energy gain, the total lengths of the linear accelerators with triplet lattices are about the same as of those with FODO lattices.

  10. Language of CTO interventions - Focus on hardware.

    Science.gov (United States)

    Mishra, Sundeep

    2016-01-01

    The knowledge of variety of chronic total occlusion (CTO) hardware and the ability to use them represents the key to success of any CTO interventions. However, the multiplicity of CTO hardware and their physical character and the terminology used by experts create confusion in the mind of an average interventional cardiologist, particularly a beginner in this field. This knowledge is available but is scattered. We aim to classify and compare the currently used devices based on their properties focusing on how physical character of each device can be utilized in a specific situation, thus clarifying and simplifying the technical discourse. Copyright © 2016. Published by Elsevier B.V.

  11. Focus and domain of sustainability values

    DEFF Research Database (Denmark)

    Rask, Morten; Madsen, Ena Alvarado; Lauring, Jakob

    values alive. We focused a multinational with more than 30 years experience with sustainability. It is one of the worlds' top manufacturers of renewable energy equipment. We found an extreme diversity in understanding sustainability. This exploratory study is based on a very broad sample within one......The increasing trend of globalization and environmental challenges make the understanding of sustainability issues in international business a growing challenge throughout the world. This study illustrates the challenge of an organization as it becomes larger and more diverse to keep the core...

  12. CRISIS FOCUS:Back to Reality

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The devastating global financial crisis stemmed from the corruption of the U.S. property market and a wide range of financial derivatives that were devised based on home mortgages. The world’s financial institutions have been hit hard, with some going bankrupt. To avoid such financial catastrophe in the future, Fan Gang, Director of the National Economic Institute, called on business people nationwide to focus more on real industries instead of blindly pouring money into financial and service sectors. He made a speech at a forum on the global financial crisis and China’s economic development. His edited speech follows:

  13. Defending against smallpox: a focus on vaccines.

    Science.gov (United States)

    Voigt, Emily A; Kennedy, Richard B; Poland, Gregory A

    2016-09-01

    Smallpox has shaped human history, from the earliest human civilizations well into the 20th century. With high mortality rates, rapid transmission, and serious long-term effects on survivors, smallpox was a much-feared disease. The eradication of smallpox represents an unprecedented medical victory for the lasting benefit of human health and prosperity. Concerns remain, however, about the development and use of the smallpox virus as a biological weapon, which necessitates the need for continued vaccine development. Smallpox vaccine development is thus a much-reviewed topic of high interest. This review focuses on the current state of smallpox vaccines and their context in biodefense efforts.

  14. Focus point from direct gauge mediation

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Sibo [Chongqing University, Department of Physics, Chongqing (China)

    2015-01-01

    This paper is devoted to the reconciliation of the tension between the theoretic expectation from naturalness and the present LHC limits on the superpartner mass bounds. We argue that in supersymmetry models of direct gauge mediation the focusing phenomenon appears, which dramatically reduces the fine tuning associated to the 126 GeV Higgs boson. This type of model is highly predictive as regards the mass spectrum, with a multi-TeV third generation, the A{sub t} term of order 1 TeV, gluino mass above LHC mass bound, and the light neutralinos and charginos below 1 TeV. (orig.)

  15. Virtual Focus Groups: New Frontiers in Research

    Directory of Open Access Journals (Sweden)

    Lyn Turney

    2005-06-01

    Full Text Available New information and communication technologies in the form of learning management systems provide unique and inventive opportunities for qualitative researchers. Their intrinsic ability to record discursive data in text format accurately and to provide safe, secure, and anonymous environments for participants makes them amenable for use as advanced research tools. In this article, the authors report on a collaborative project that tested the potential of online discussion boards for use in virtual focus groups. What the researchers found was that not only was the method theoretically sound, it actually enhanced their ability to connect with difficult-to-access populations that were disparately spread.

  16. Service Academy 2007 Gender Relations Focus Groups

    Science.gov (United States)

    2007-08-01

    I’ve been here. I feel I heard a lot of them my plebe [freshman] year, and then as time has gone on, because they made it such a focus, I feel like...they’re discussing it and it has become less of an issue. I feel like the plebes have never even heard it or heard of anyone using that term. I...than it was a few years ago. – “My plebe [freshman] year we had drunk firsties [seniors] coming in almost every night to my room just to sit and talk

  17. Socrates' questions: a focus for nursing.

    Science.gov (United States)

    Bunkers, Sandra S

    2004-07-01

    This column focuses on the philosophical dialogue originated by Socrates. Six questions that Socrates would ask the ancient Greeks are explored in discussing a book written by Phillips entitled Six Questions of Socrates. These questions were: What is virtue? What is moderation? What is justice? What is good? What is courage? What is piety? A human becoming perspective is used as a lens to view the discussion on these questions and the question is posed, "What would it be like to frame discussions on health and quality of life around Socrates' questions?" Parse's teaching-learning processes are presented as a means of creating an environment where dialogue on these questions can occur.

  18. Mixed Waste Focus Area program management plan

    Energy Technology Data Exchange (ETDEWEB)

    Beitel, G.A.

    1996-10-01

    This plan describes the program management principles and functions to be implemented in the Mixed Waste Focus Area (MWFA). The mission of the MWFA is to provide acceptable technologies that enable implementation of mixed waste treatment systems developed in partnership with end-users, stakeholders, tribal governments and regulators. The MWFA will develop, demonstrate and deliver implementable technologies for treatment of mixed waste within the DOE Complex. Treatment refers to all post waste-generation activities including sampling and analysis, characterization, storage, processing, packaging, transportation and disposal.

  19. Seven Issues Should Be Focused on Investment

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

      According to the investment situation of the first half of this year, under macro-control of the central government, the super high-speed investment momentum in the first half of this year was controlled and some overheated industries were becoming normal. Influenced by many positive factors, the targets of macro-control as expected will be achieved. However, in order to further settle this policy and realize the economic soft-landing, the following seven issues should be focused on.……

  20. Determinants of psychosis vulnerability; focus on MEF2- and glucocorticoid signaling

    NARCIS (Netherlands)

    Speksnijder, Niels

    2013-01-01

    Schizophrenia is heritable, but even in monozygotic twins differences in susceptibly exists. What is causing this difference in genetically identical individuals? The objective of this thesis was to identify novel susceptibility genes and pathways for psychosis in a psychostimulant mouse model which

  1. Experimental determination of natural carbonate rock dissolution rates with a focus on temperature dependency

    Science.gov (United States)

    Kirstein, Jens; Hellevang, Helge; Haile, Beyene G.; Gleixner, Gerd; Gaupp, Reinhard

    2016-05-01

    The denudation of carbonate rocks at landscape scale is controlled by factors like mineral composition, temperature, precipitation, runoff, fracture spacing and vegetation cover. Knowledge on carbonate denudation is important in order to understand landscape development and long-term terrestrial/marine carbon transport, but there are few laboratory studies done on weathering rates of natural carbonate rocks under the low temperatures relevant for glacial-interglacial periods. To enhance the understanding of carbonate dissolution kinetics we studied low-temperature dissolution reactions of various natural Triassic carbonate rocks belonging to the Lower Muschelkalk in Germany. We conducted batch and flow-through experiments investigating the direct correlation of dissolution rates with temperature, and to establish whether the fine-grained carbonate rocks (micrite) are more reactive than the coarser-grained sparitic limestones. By increasing the temperature from 5 to 26 °C far-from-equilibrium dissolution rates of micritic and sparitic limestone samples increased from 2.42 × 10- 07 to 10.88 × 10- 07 and 4.19 × 10- 07 to 7.74 × 10- 07 mol m- 2 s- 1, respectively (Specific Surface Areas (SSA) of about 0.006-0.01 m2/g). The dissolution rates of dolomite rock samples varied only slightly from 1.06 × 10- 07 to 2.02 × 10- 07 mol m- 2 s- 1 (SSA approximately 0.002 m2/g) in the temperature range 5-25 °C at circum-neutral pH. The obtained apparent activation energies are in the range of earlier experiments done at higher temperatures, but there is a distinct difference between the calcite in the micrite (~ 51 kJ/mol) and sparitic (~ 20-22 kJ/mol) lithologies, indicating that the dissolution mechanisms are not the same. Using these activation energies in modelling of natural carbonate denudation we see that there is a clear effect of changing temperature, but this is mostly through the increased solubility at lower temperatures and not through the increasing far-from-equilibrium dissolution rates at higher temperatures. Formation of fluid pathways by preferential dissolution of framework calcite crystals is suggested to form infiltration pathways and affect denudation rates. The difference in crystal size between the micritic and sparitic limestones will affect the formation of such pathways (larger crystals may create fewer and larger conduits) and this is expected to be more important for the long-term denudation than the differences in activation energies.

  2. Future time perspective and promotion focus as determinants of intraindividual change in work motivation

    NARCIS (Netherlands)

    Kooij, T.A.M.; Bal, P.M.; Kanfer, R.

    2014-01-01

    In the near future, workforces will increasingly consist of older workers. At the same time, research has demonstrated that work-related growth motives decrease with age. Although this finding is consistent with life span theories, such as the selection optimization and compensation (SOC) model, we

  3. Determinants of eating behaviour in university students: a qualitative study using focus group discussions

    OpenAIRE

    Deliens, Tom; Clarys, Peter; De Bourdeaudhuij, Ilse; Deforche, Benedicte

    2014-01-01

    Background: College or university is a critical period regarding unhealthy changes in eating behaviours in students. Therefore, the purpose of this study was to explore which factors influence Belgian (European) university students' eating behaviour, using a qualitative research design. Furthermore, we aimed to collect ideas and recommendations in order to facilitate the development of effective and tailored intervention programs aiming to improve healthy eating behaviours in university stude...

  4. Caries Risk Assessment for Determination of Focus and Intensity of Prevention in a Dental School Clinic.

    Science.gov (United States)

    Dodds, Michael W. J.; Suddick, Richard P.

    1995-01-01

    A study at the University of Texas, San Antonio's dental school resulted in development of a system of caries risk assessment, applied to all undergraduate clinic patients. The rationale, structure, elements, and application of the system are outlined, and course content supporting the system is noted. Need for validation and other improvements is…

  5. Determination of posttranslational modifications of photoreceptor differentiation factor NRL: focus on SUMOylation.

    Science.gov (United States)

    Roger, Jerome E; Nellissery, Jacob; Swaroop, Anand

    2012-01-01

    Conjugation of SUMO (small ubiquitin-related modifier 1) is a critical posttranslational modification, with significant impact on protein function/activity. Here, we describe direct SUMOylation of GST (glutathione S-transferase)-fusion protein and immunoprecipitation assays for investigating SUMOylation of any protein of interest. We have employed these methods to examine SUMOylation of the basic-motif leucine zipper transcription factor NRL.

  6. Ethnic differences in diet: A focus on methodology, determinants and Type 2 Diabetes Mellitus

    NARCIS (Netherlands)

    Dekker, L.H.

    2015-01-01

    The overall aim of this thesis was to enhance the scientific basis for dietary analysis and the role of diet in T2DM prevalence in an ethnically diverse population. A large multi-ethnic population including five ethnic groups - South Asian origin Surinamese, African origin Surinamese, Turkish, Moroc

  7. Determinants of psychosis vulnerability; focus on MEF2- and glucocorticoid signaling

    NARCIS (Netherlands)

    Speksnijder, Niels

    2013-01-01

    Schizophrenia is heritable, but even in monozygotic twins differences in susceptibly exists. What is causing this difference in genetically identical individuals? The objective of this thesis was to identify novel susceptibility genes and pathways for psychosis in a psychostimulant mouse model which

  8. The Determinants of Research and Development Investment in the Pharmaceutical Industry: Focus on Financial Structures.

    Science.gov (United States)

    Lee, Munjae; Choi, Mankyu

    2015-10-01

    This study analyzes the influence of the financial structure of pharmaceutical companies on R&D investment to create a next-generation profit source or develop relatively cost-effective drugs to maximize enterprise value. The period of the empirical analysis is from 2000 to 2012. Financial statements and comments in general and internal transactions were extracted from TS-2000 of the Korea Listed Company Association (KLCA), and data related to stock price is extracted from KISVALUE-Ⅲ of NICE Information Service Co., Ltd. Stata 12.0 was used as the statistical package for panel analysis. The current ratio had a positive influence on R&D investment, the debt ratio had a negative influence on R&D investment, and return on investment and net sales growth rate did not have a significant influence on R&D investment. It was found in this study that the higher liquidity ratio, the greater the R&D investment. The stability of pharmaceutical companies has a negative influence on R&D investment. This finding is consistent with the prediction that if a company faces a financial risk, it will be passive in R&D investment due to its financial difficulties.

  9. Focus Group Study Exploring Factors Related to Frequent Sickness Absence.

    Directory of Open Access Journals (Sweden)

    Annette Notenbomer

    Full Text Available Research investigating frequent sickness absence (3 or more episodes per year is scarce and qualitative research from the perspective of frequent absentees themselves is lacking. The aim of the current study is to explore awareness, determinants of and solutions to frequent sickness absence from the perspective of frequent absentees themselves.We performed a qualitative study of 3 focus group discussions involving a total of 15 frequent absentees. Focus group discussions were audiotaped and transcribed verbatim. Results were analyzed with the Graneheim method using the Job Demands Resources (JD-R model as theoretical framework.Many participants were not aware of their frequent sickness absence and the risk of future long-term sickness absence. As determinants, participants mentioned job demands, job resources, home demands, poor health, chronic illness, unhealthy lifestyles, and diminished feeling of responsibility to attend work in cases of low job resources. Managing these factors and improving communication (skills were regarded as solutions to reduce frequent sickness absence.The JD-R model provided a framework for determinants of and solutions to frequent sickness absence. Additional determinants were poor health, chronic illness, unhealthy lifestyles, and diminished feeling of responsibility to attend work in cases of low job resources. Frequent sickness absence should be regarded as a signal that something is wrong. Managers, supervisors, and occupational health care providers should advise and support frequent absentees to accommodate job demands, increase both job and personal resources, and improve health rather than express disapproval of frequent sickness absence and apply pressure regarding work attendance.

  10. Nonlinear Effect on Focusing Gain of a Focusing Transducer with a Wide Aperture Angle

    Institute of Scientific and Technical Information of China (English)

    LIU Ming-He; ZHANG Dong; GONG Xiu-Fen

    2007-01-01

    @@ Nonlinear effect on focusing gain of acoustic field radiated from a 1-MHz focusing transmitter with a wide aperture angle of 35° is theoretically and experimentally investigated. With the enhancement of nonlinearity, the focusing gains of both intensity and peak positive pressure show non-monotonic behaviour. There exist the same saturated levels at which the maximum outputs are reached and their spatial distributions are more localized. In contrast,the peak negative pressure always decreases monotonically and its spatial distribution is less localized.

  11. Diode and Final Focus Simulations for DARHT

    Science.gov (United States)

    Hughes, Thomas P.; Welch, Dale R.; Carlson, Randolph L.

    1997-05-01

    We have used the numerical simulation codes uc(ivory,) uc(iprop) and uc(pbguns) to simulate beam dynamics in the diode and final focus of the 4 kA, 20 MV DARHT linear accelerator. A low emittance 4 MV, 4 kA source for a 4-pulse injector was designed using uc(ivory) and uc(pbguns.) Due to the long pulse length (four 70 ns pulses over 1 μsec), we have kept the field stress to stacks. The normalized edge emittance produced by the diode optics is only ≈ 130 mm-mrad. In the final-focus region, we have used uc(iprop) to model the effect of ion emission from the target. The intense electric field of the beam at the 1 mm diameter focal spot produces substantial ion velocities, and, if the space-charge-limited current density can be supplied, significant focal spot degradation may occur due to ion space-charge. Calculations for the ITS test stand, which has a larger focal spot, show that the effect should be observable for H^+ and C^+ ion species. The effect may be lessened if there is insufficient ion density on the target to supply the space-charge-limited current density, or if the ion charge-to-mass ratio is sufficiently large.

  12. Editorial: Focus on Extra Space Dimensions

    Science.gov (United States)

    Agashe, Kaustubh; Pomarol, Alex

    2010-07-01

    Experiments at the Large Hadron Collider (LHC) have just started. In addition to verifying the Standard Model (SM) of particle physics, these experiments will probe a new energy frontier and test extensions of the SM. The existence of extra dimensions is one of the most attractive possibilities for physics beyond the SM. This focus issue contains a collection of articles addressing both theoretical and phenomenological aspects of extra-dimensional models. Focus on Extra Space Dimensions Contents Minimal universal extra dimensions in CalcHEP/CompHEP AseshKrishna Datta, Kyoungchul Kong and Konstantin T Matchev Disordered extra dimensions Karim Benakli Codimension-2 brane-bulk matching: examples from six and ten dimensions Allan Bayntun, C P Burgess and Leo van Nierop Gauge threshold corrections in warped geometry Kiwoon Choi, Ian-Woo Kim and Chang Sub Shin Holographic methods and gauge-Higgs unification in flat extra dimensions Marco Serone Soft-wall stabilization Joan A Cabrer, Gero von Gersdorff and Mariano Quirós Warped five-dimensional models: phenomenological status and experimental prospects Hooman Davoudiasl, Shrihari Gopalakrishna, Eduardo Pontón and José Santiago

  13. Developing a focused scald-prevention program.

    Science.gov (United States)

    Cagle, Kathleen M; Davis, James W; Dominic, William; Ebright, Steffanie; Gonzales, Wendy

    2006-01-01

    Scalds account for a high percentage of burn injuries in young children. The purpose of this project was to use a formative evaluation process to design a pilot scald-prevention program for a high-risk population. The burn registry and U.S. Census were used to define a high-risk population. A total of 53 children younger than age 6 were admitted to a local burn center with scalds during a 4-year period. Cooking or food accounted for 84% of these injuries. A total of 21% of the patients resided in one zip code, representing an incidence rate of 23 per 100,000, which was statistically significant. Focus group meetings were conducted with parents in this zip code. They were queried about scald injury knowledge, prevention practices, and attitudes toward interventions. A prevention program was designed based on the findings. Workshops are conducted with high-risk groups in the zip code. Attendees consent to a home visit where prevention practices are assessed and taught. A pre/post test and home risk assessment survey is used to measure change. The Burn Registry, U.S. Census, and focus groups were complimentary formative evaluation measures that assisted in developing a targeted scald prevention project.

  14. Focusing on reproductive health for adolescents.

    Science.gov (United States)

    1995-06-01

    JOICFP is producing a still photo video consisting of three segments from photos shot in Bangladesh (April 22 - May 2), Thailand (May 2-15), and Mexico (June 29 - July 7) in 1995. The first segment highlights the daily life of a husband, aged 20, and his wife, Moni, aged 14. Moni married at age 13, before the onset of menstruation, and now serves and feeds her husband's large extended family. The Family Planning Association of Bangladesh (FPAB), the local implementing agent of the Sustainable Community-based Family Planning/Maternal and Child Health (FP/MCH) Project with Special Focus on Women, which is supported by the United Nations Population Fund (UNFPA) and executed by JOICFP, introduced Moni to the concept of reproductive health and encouraged her to join other women in activities designed to improve their health and raise their economic status. The second segment depicts the life of a former commercial sex worker who is undergoing occupational skill development training promoted by the Population and Community Development Association. The girl is now a leader of teenagers in her village; she works to change attitudes that sent her to work as a prostitute with an estimated 150,000 other poor rural teenage women. The third segment focuses on teen pregnancy and the efforts of the Mexican Foundation for Family Planning (MEXFAM) in the areas of health care and education for adolescents.

  15. Focusing on the essentials: learning for performance

    Directory of Open Access Journals (Sweden)

    Murphy Catherine J

    2008-12-01

    Full Text Available Abstract As The World health report 2006 emphasized, there is increasing consensus that training programmes should focus on "know-how" instead of "know-all." Health workers need to know how to do the job they will be expected to do. IntraHealth International's Learning for performance: a guide and toolkit for health worker training and education programs offers a step-by-step, customizable approach designed to develop the right skills linked to job responsibilities. Using Learning for performance (LFP yields more efficient training that focuses on what is essential for health workers to do their jobs and on effective learning methods, while addressing the factors that ensure application of new skills on the job. This brief communication describes the Learning for performance approach and initial findings from its application for pre-service education and in-service training in three countries: India, Mali and Bangladesh. Based on IntraHealth's experiences, the author provides thoughts on how LFP's performance-based learning approach can be a useful tool in training scale-up to strengthen human resources for health.

  16. Focusing parabolic guide for very small samples

    Energy Technology Data Exchange (ETDEWEB)

    Hils, T.; Boeni, P.; Stahn, J

    2004-07-15

    Modern materials can often only be grown in small quantities. Therefore, neutron-scattering experiments are difficult to perform due to the low signal. In order to increase the flux at the sample position, we have developed the concept of a small focusing guide tube with parabolically shaped walls that are coated with supermirror m=3. The major advantage of parabolic focusing is that the flux maximum occurs not at the exit of the tube. It occurs at the focal point that can be several centimeters away from the exit of the tube. We show that an intensity gain of 6 can easily be obtained. Simulations using the software package McStas demonstrate that gain factors up to more than 50 can be realised on a spot size of approximately 1.2 mm diameter. For PGAA we expect flux gains of up to three orders of magnitude if multiplexing is used. We show that elliptic ballistic guides lead to flux gains of more than 6.

  17. Monte Carlo simulations for focusing elliptical guides

    Energy Technology Data Exchange (ETDEWEB)

    Valicu, Roxana [FRM2 Garching, Muenchen (Germany); Boeni, Peter [E20, TU Muenchen (Germany)

    2009-07-01

    The aim of the Monte Carlo simulations using McStas Programme was to improve the focusing of the neutron beam existing at PGAA (FRM II) by prolongation of the existing elliptic guide (coated now with supermirrors with m=3) with a new part. First we have tried with an initial length of the additional guide of 7,5cm and coatings for the neutron guide of supermirrors with m=4,5 and 6. The gain (calculated by dividing the intensity in the focal point after adding the guide by the intensity at the focal point with the initial guide) obtained for this coatings indicated that a coating with m=5 would be appropriate for a first trial. The next step was to vary the length of the additional guide for this m value and therefore choosing the appropriate length for the maximal gain. With the m value and the length of the guide fixed we have introduced an aperture 1 cm before the focal point and we have varied the radius of this aperture in order to obtain a focused beam. We have observed a dramatic decrease in the size of the beam in the focal point after introducing this aperture. The simulation results, the gains obtained and the evolution of the beam size will be presented.

  18. Focusing parabolic guide for very small samples

    Science.gov (United States)

    Hils, T.; Boeni, P.; Stahn, J.

    2004-07-01

    Modern materials can often only be grown in small quantities. Therefore, neutron-scattering experiments are difficult to perform due to the low signal. In order to increase the flux at the sample position, we have developed the concept of a small focusing guide tube with parabolically shaped walls that are coated with supermirror m=3. The major advantage of parabolic focusing is that the flux maximum occurs not at the exit of the tube. It occurs at the focal point that can be several centimeters away from the exit of the tube. We show that an intensity gain of 6 can easily be obtained. Simulations using the software package McStas demonstrate that gain factors up to more than 50 can be realised on a spot size of approximately 1.2 mm diameter. For PGAA we expect flux gains of up to three orders of magnitude if multiplexing is used. We show that elliptic ballistic guides lead to flux gains of more than 6.

  19. Focusing properties of discrete RF quadrupoles

    Science.gov (United States)

    Li, Zhi-Hui; Wang, Zhi-Jun

    2017-08-01

    The particle motion equation for a Radio Frequency (RF) quadrupole is derived. The motion equation shows that the general transform matrix of a RF quadrupole with length less than or equal to 0.5βλ (β is the relativistic velocity of particles and λ is wavelength of radio frequency electromagnetic field) can describe the particle motion in an arbitrarily long RF quadrupole. By iterative integration, the general transform matrix of a discrete RF quadrupole is derived from the motion equation. The transform matrix is in form of a power series of focusing parameter B. It shows that for length less than βλ, the series up to the 2nd order of B agrees well with the direct integration results for B up to 30, while for length less than 0.5βλ, the series up to 1st order is already a good approximation of the real solution for B less than 30. The formula of the transform matrix can be integrated into linac or beam line design code to deal with the focusing of discrete RF quadrupoles. Supported by National Natural Science Foundation of China (11375122, 11511140277) and Strategic Priority Research Program of the Chinese Academy of Sciences (XDA03020705)

  20. An ultra miniature pinch-focus discharge

    Energy Technology Data Exchange (ETDEWEB)

    Soto, L.; Pavez, C.; Moreno, J. [Comision Chilena de Energia Nuclear, Santiago (Chile); Pavez, C. [Universidad de Concepcion (Chile); Barbaglia, M.; Clausse, A. [Universidad Nacional del Centro, Pladema-CNEA-Conicet, Tandil (Argentina)

    2004-07-01

    As a way to investigate the minimum energy to produce a pinch plasma focus discharge, an ultra miniature device has been designed and constructed (nano focus NF: 5 nF, 5-10 kV, 5-10 kA, 60-250 mJ, 16 ns time to peak current). Sub-millimetric anode radius covered by a coaxial insulator were used for experiments in hydrogen. Evidence of pinch was observed in electrical signals in discharges operating at 60 mJ. A single-frame image converter camera (4 ns exposure) was used to obtain plasma images in the visible range. The dynamics observed from the photographs is consistent with: a) formation of a plasma sheath close to the insulator surface, b) fast axial motion of the plasma sheath, c) radial compression over the anode, and d) finally the plasma is detached from the anode in the axial direction. The total time since stage a) to d) was observed to be about 30 ns. X ray and neutron emission is being studied. Neutron yield of the order of 10{sup 3} neutrons per shot is expected for discharges operating in deuterium at 10 kA. (authors)

  1. Drawing road networks with focus regions.

    Science.gov (United States)

    Haunert, Jan-Henrik; Sering, Leon

    2011-12-01

    Mobile users of maps typically need detailed information about their surroundings plus some context information about remote places. In order to avoid that the map partly gets too dense, cartographers have designed mapping functions that enlarge a user-defined focus region--such functions are sometimes called fish-eye projections. The extra map space occupied by the enlarged focus region is compensated by distorting other parts of the map. We argue that, in a map showing a network of roads relevant to the user, distortion should preferably take place in those areas where the network is sparse. Therefore, we do not apply a predefined mapping function. Instead, we consider the road network as a graph whose edges are the road segments. We compute a new spatial mapping with a graph-based optimization approach, minimizing the square sum of distortions at edges. Our optimization method is based on a convex quadratic program (CQP); CQPs can be solved in polynomial time. Important requirements on the output map are expressed as linear inequalities. In particular, we show how to forbid edge crossings. We have implemented our method in a prototype tool. For instances of different sizes, our method generated output maps that were far less distorted than those generated with a predefined fish-eye projection. Future work is needed to automate the selection of roads relevant to the user. Furthermore, we aim at fast heuristics for application in real-time systems.

  2. Art exhibit focuses on African astronomy

    Science.gov (United States)

    Showstack, Randy

    2012-07-01

    Connections between Africans and astronomy are the focus of a new exhibition in the National Museum of African Art in Washington, D. C. "African Cosmos: Stellar Arts," which includes artwork, cultural items, and scientific displays from ancient to contemporary times, is the first major exhibit "that brings together arts and science focused on Africa's contribution to keen observations of the heavens over time," curator Christine Mullen Kreamer said at a 20 June news briefing. Among the exhibit's nearly 100 objects are an ancient Egyptian mummy board that includes a representation of the sky goddess Nut, sculptures by the Dogon people of Mali depicting figures in relation to the cosmos, a video that uses data from two square degrees of the Hubble Space Telescope Cosmic Evolution Survey, and a nearly floor-to-ceiling "Rainbow Serpent" constructed of plastic containers by Benin artist Hazoume. An untitled acrylic painting (Figure 1) by South African Gavin Jantjes evokes a myth of the Khoi San people of southern Africa, as it portrays a girl throwing evening fire embers into the night sky, where they remained as the Milky Way.

  3. GRI: focusing on the evolving violent Universe

    CERN Document Server

    Knödlseder, Jürgen; Frontera, Filippo; Bazzano, Angela; Christensen, Finn E; Hernanz, Margarida; Wunderer, Cornelia

    2007-01-01

    The Gamma-Ray Imager (GRI) is a novel mission concept that will provide an unprecedented sensitivity leap in the soft gamma-ray domain by using for the first time a focusing lens built of Laue diffracting crystals. The lens will cover an energy band from 200 - 1300 keV with an effective area reaching 600 cm2. It will be complemented by a single reflection multilayer coated mirror, extending the GRI energy band into the hard X-ray regime, down to ~10 keV. The concentrated photons will be collected by a position sensitive pixelised CZT stack detector. We estimate continuum sensitivities of better than 10^-7 ph/cm2/s/keV for a 100 ks exposure; the narrow line sensitivity will be better than 3 x 10^-6 ph/cm2/s for the same integration time. As focusing instrument, GRI will have an angular resolution of better than 30 arcsec within a field of view of roughly 5 arcmin - an unprecedented achievement in the gamma-ray domain. Owing to the large focal length of 100 m of the lens and the mirror, the optics and detector ...

  4. Malformations of cortical development and neocortical focus.

    Science.gov (United States)

    Luhmann, Heiko J; Kilb, Werner; Clusmann, Hans

    2014-01-01

    Developmental neocortical malformations resulting from abnormal neurogenesis, disturbances in programmed cell death, or neuronal migration disorders may cause a long-term hyperexcitability. Early generated Cajal-Retzius and subplate neurons play important roles in transient cortical circuits, and structural/functional disorders in early cortical development may induce persistent network disturbances and epileptic disorders. In particular, depolarizing GABAergic responses are important for the regulation of neurodevelopmental events, like neurogenesis or migration, while pathophysiological alterations in chloride homeostasis may cause epileptic activity. Although modern imaging techniques may provide an estimate of the structural lesion, the site and extent of the cortical malformation may not correlate with the epileptogenic zone. The neocortical focus may be surrounded by widespread molecular, structural, and functional disturbances, which are difficult to recognize with imaging technologies. However, modern imaging and electrophysiological techniques enable focused hypotheses of the neocortical epileptogenic zone, thus allowing more specific epilepsy surgery. Focal cortical malformation can be successfully removed with minimal rim, close to or even within eloquent cortex with a promising risk-benefit ratio.

  5. Focused electron beam induced deposition: A perspective

    Directory of Open Access Journals (Sweden)

    Michael Huth

    2012-08-01

    Full Text Available Background: Focused electron beam induced deposition (FEBID is a direct-writing technique with nanometer resolution, which has received strongly increasing attention within the last decade. In FEBID a precursor previously adsorbed on a substrate surface is dissociated in the focus of an electron beam. After 20 years of continuous development FEBID has reached a stage at which this technique is now particularly attractive for several areas in both, basic and applied research. The present topical review addresses selected examples that highlight this development in the areas of charge-transport regimes in nanogranular metals close to an insulator-to-metal transition, the use of these materials for strain- and magnetic-field sensing, and the prospect of extending FEBID to multicomponent systems, such as binary alloys and intermetallic compounds with cooperative ground states.Results: After a brief introduction to the technique, recent work concerning FEBID of Pt–Si alloys and (hard-magnetic Co–Pt intermetallic compounds on the nanometer scale is reviewed. The growth process in the presence of two precursors, whose flux is independently controlled, is analyzed within a continuum model of FEBID that employs rate equations. Predictions are made for the tunability of the composition of the Co–Pt system by simply changing the dwell time of the electron beam during the writing process. The charge-transport regimes of nanogranular metals are reviewed next with a focus on recent theoretical advancements in the field. As a case study the transport properties of Pt–C nanogranular FEBID structures are discussed. It is shown that by means of a post-growth electron-irradiation treatment the electronic intergrain-coupling strength can be continuously tuned over a wide range. This provides unique access to the transport properties of this material close to the insulator-to-metal transition. In the last part of the review, recent developments in mechanical

  6. Differences in Attentional Focus Associated With Recovery From Sports Injury: Does Injury Induce an Internal Focus?

    Science.gov (United States)

    Gray, Rob

    2015-12-01

    Although it is commonly believed that focusing too much attention on the injured body area impairs recovery in sports, this has not been directly assessed. The present study investigated attentional focus following sports injury. Experienced baseball position players recovering from knee surgery (Expt 1) and baseball pitchers recovering from elbow surgery (Expt 2) performed simulated batting and pitching respectively. They also performed three different secondary tasks: leg angle judgments, arm angle judgments, and judgments about the ball leaving their bat/hand. Injured athletes were compared with expert and novice control groups. Performance on the secondary tasks indicated that the injured batters had an internal focus of attention localized on the area of the injury resulting in significantly poorer batting performance as compared with the expert controls. Injured pitchers had a diffuse, internal attentional focus similar to that of novices resulting in poorer pitching performance as compared with the expert controls.

  7. All in Focus Image Generation based on New Focusing Measure Operators

    Directory of Open Access Journals (Sweden)

    Hossam Eldeen M. Shamardan

    2016-12-01

    Full Text Available To generate an all in focus image, the Shape-From-Focus (SFF is used. The SFF key is finding the optimal focus depth at each pixel or area in an image within sequence of images. In this paper two new focusing measure operators are suggested to be used for SFF. The suggested operators are based on modification for the state of art tool for time-frequency analysis, the Stockwell Transform (ST. The first operator depends on Discrete Orthogonal Stockwell Transform (DOST which represents a pared version of ST, while the other depends on Pixelwise DOST (P-DOST which provides a local spatial frequency description. Both of the operators provides the computational complexity and memory demand efficiency compared to the operator depending on ST. A comparison between the suggested operators to operators based on ST are performed and showed that the suggested operators’ performances are as analogous to that of ST.

  8. The Effects of Focus on Forms and Focus on Form in Teaching Complex Grammatical Structures

    Science.gov (United States)

    Pawlak, Miroslaw

    2012-01-01

    The classroom-based study reported in the present paper sought to compare the effectiveness of the focus on forms (FonFs) and focus on form (FonF) approach in teaching English third conditional to Polish high school students. It involved three intact classes, randomly designated as FonF (n = 34), FonFs (n = 36), and Control (n = 35) with a pretest…

  9. NRMRL/TTSD CUSTOMER SATISFACTION FOCUS GROUP

    Science.gov (United States)

    TTB uses a variety of technology transfer products and tools to communicate risk and information about technologies and research. TTB has begun a project to use EPA's generic Customer Satisfaction Survey Information Collection Request (ICR) to determine satisfaction with their pr...

  10. NRMRL/TTSD CUSTOMER SATISFACTION FOCUS GROUP

    Science.gov (United States)

    TTB uses a variety of technology transfer products and tools to communicate risk and information about technologies and research. TTB has begun a project to use EPA's generic Customer Satisfaction Survey Information Collection Request (ICR) to determine satisfaction with their pr...

  11. Focus on molecular plant-nematode interactions

    NARCIS (Netherlands)

    Hogenhout, S.; Mitchum, M.; Smant, G.

    2013-01-01

    Sedentary plant-parasitic nematodes engage in a long-lasting and intimate relationship with their host plant. This interaction starts in the soil when freshly hatched infective juveniles are attracted to specific parts of a host plant root system. Little is known of what determines the attractivenes

  12. Gene therapy in India: A focus

    Indian Academy of Sciences (India)

    Sarvani Chodisetty; Everette Jacob Remington Nelson

    2014-06-01

    Gene therapy refers to the treatment of genetic diseases using normal copies of the defective genes. It has the potential to cure any genetic disease with long-lasting therapeutic benefits. It remained an enigma for a long period of time, which was followed by a series of setbacks in the late 1990s. Gene therapy has re-emerged as a therapeutic option with reports of success from recent clinical studies. The United States and Europe has been pioneers in this field for over two decades. Recently, reports of gene therapy have started coming in from Asian countries like China, Japan and Korea. This review focuses on the current status of gene therapy in India.

  13. Teaching Introductory Physics with an Environmental Focus

    Science.gov (United States)

    Martinuk, Mathew ``Sandy''; Moll, Rachel F.; Kotlicki, Andrzej

    2010-09-01

    Throughout North America the curriculum of introductory physics courses is nearly standardized. In 1992, Tobias wrote that four texts dominate 90% of the introductory physics market and current physics education research is focusing on how to sustain educational reforms.2 The instructional team at the University of British Columbia (UBC) recently implemented some key curriculum and pedagogical changes in Physics 100, their algebra-based introductory course for non-physics majors. These changes were aimed at improving their students' attitudes toward physics and their ability to apply physics concepts to useful real-life situations. In order to demonstrate that physics is relevant to real life, a theme of energy and environment was incorporated into the course.

  14. Focused Real-Time Ultrasonography for Nephrologists

    Science.gov (United States)

    Kaptein, Matthew J.

    2017-01-01

    We propose that renal consults are enhanced by incorporating a nephrology-focused ultrasound protocol including ultrasound evaluation of cardiac contractility, the presence or absence of pericardial effusion, inferior vena cava size and collapsibility to guide volume management, bladder volume to assess for obstruction or retention, and kidney size and structure to potentially gauge chronicity of renal disease or identify other structural abnormalities. The benefits of immediate and ongoing assessment of cardiac function and intravascular volume status (prerenal), possible urinary obstruction or retention (postrenal), and potential etiologies of acute kidney injury or chronic kidney disease far outweigh the limitations of bedside ultrasonography performed by nephrologists. The alternative is reliance on formal ultrasonography, which creates a disconnect between those who order, perform, and interpret studies, creates delays between when clinical questions are asked and answered, and may increase expense. Ultrasound-enhanced physical examination provides immediate information about our patients, which frequently alters our assessments and management plans.

  15. Focused electrojetting for nanoscale 3-D fabrication

    Science.gov (United States)

    Lee, Minhee; Kim, Ho-Young

    2012-11-01

    Although extreme miniaturization of components in integrated circuits and biochemical chips has driven the development of various nanofabrication technologies, three-dimensional fabrication of nanoscale objects is still in its infancy. Here we propose a novel method to fabricate a free-standing nanowall by the line-by-line deposition of electrospun polymer nanofibers. We show that the electrified nanojet, which tends to get unstable as traveling in free space due to the Coulombic repulsion, can be stably focused onto a narrow line of metal electrode. On the conducting line, the polymer nanojet is spontaneously folded successively to form a wall-like structure. We rationalize the period of spontaneous folding by balancing the tension in the polymer fiber with the electrostatic interaction of the fiber with the metal ground. This novel fabrication scheme can be applied for the development of three-dimensional bioscaffolds, nanofilters and nanorobots.

  16. Focus on the Physics of Cancer

    CERN Document Server

    Risler, Thomas

    2015-01-01

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This `focus on' collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  17. Focus on the physics of cancer

    Science.gov (United States)

    Risler, Thomas

    2015-05-01

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This ‘focus on’ collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  18. Literature in Focus Perspectives on LHC Physics

    CERN Multimedia

    2008-01-01

    The CERN Library invites you to a book presentation, a Literature in Focus event. The Large Hadron Collider (LHC) will be the world’s largest, highest energy and highest intensity particle accelerator. This is a timely book with several perspectives on the hoped-for discoveries from the LHC. This book provides an overview of the techniques that will be crucial for finding new physics at the LHC, as well as perspectives on the importance and implications of the discoveries. Among the accomplished contributors to this book are leaders and visionaries in the field of particle physics beyond the Standard Model, including two Nobel Laureates (Steven Weinberg and Frank Wilczek). With its blend of popular and technical contents, the book will have wide appeal, not only to physical scientists but also to those in related fields. Perspectives on LHC Physics (World Scientific Publishing) Gordon Kane and Aaron Pierce (eds.) Tuesday 12 August, 4.30pm Council Chamber Refresh...

  19. Variable-focus cylindrical liquid lens array

    Science.gov (United States)

    Zhao, Wu-xiang; Liang, Dong; Zhang, Jie; Liu, Chao; Zang, Shang-fei; Wang, Qiong-hua

    2013-06-01

    A variable-focus cylindrical liquid lens array based on two transparent liquids of different refractive index is demonstrated. An elastic membrane divides a transparent reservoir into two chambers. The two chambers are filled with liquid 1 and liquid 2, respectively, which are of different refractive index. The micro-clapboards help liquid 1, liquid 2 and the elastic membrane form a cylindrical lens array. Driving these two liquids to flow can change the shape of the elastic membrane as well as the focal length. In this design, the gravity effect of liquid can be overcome. A demo lens array of positive optical power is developed and tested. Moreover, a potential application of the proposed lens array for autostereoscopic 3D displays is emphasized.

  20. Focus: Global histories of science. Introduction.

    Science.gov (United States)

    Sivasundaram, Sujit

    2010-03-01

    An interest in global histories of science is not new. Yet the project envisioned by this Focus section is different from that pursued by natural historians and natural philosophers in the early modern age. Instead of tracing universal patterns, there is value in attending to the connections and disconnections of science on the global stage. Instead of assuming the precision of science's boundaries, historians might consider the categories of "science" and "indigenous knowledge" to have emerged from globalization. New global histories of science will be characterized by critical reflection on the limits of generalization, as well as a creative adoption of new sources, methods, and chronologies, in an attempt to decenter the European history of science. Such a project holds the promise of opening up new conversations between historians, anthropologists, philosophers, and sociologists of science. It is of critical importance if the discipline is not to fragment into regional and national subfields or become dominated by structural frameworks such as imperialism.

  1. Gaia: focus, straylight and basic angle

    CERN Document Server

    Mora, A; Bombrun, A; Boyadian, J; Chassat, F; Corberand, P; Davidson, M; Doyle, D; Escolar, D; Gielesen, W L M; Guilpain, T; Hernandez, J; Kirschner, V; Klioner, S A; Koeck, C; Laine, B; Lindegren, L; Serpell, E; Tatry, P; Thoral, P

    2016-01-01

    The Gaia all-sky astrometric survey is challenged by several issues affecting the spacecraft stability. Amongst them, we find the focus evolution, straylight and basic angle variations Contrary to pre-launch expectations, the image quality is continuously evolving, during commissioning and the nominal mission. Payload decontaminations and wavefront sensor assisted refocuses have been carried out to recover optimum performance. An ESA-Airbus DS working group analysed the straylight and basic angle issues and worked on a detailed root cause analysis. In parallel, the Gaia scientists have also analysed the data, most notably comparing the BAM signal to global astrometric solutions, with remarkable agreement. In this contribution, a status review of these issues will be provided, with emphasis on the mitigation schemes and the lessons learned for future space missions where extreme stability is a key requirement.

  2. Gaia: focus, straylight and basic angle

    Science.gov (United States)

    Mora, A.; Biermann, M.; Bombrun, A.; Boyadjian, J.; Chassat, F.; Corberand, P.; Davidson, M.; Doyle, D.; Escolar, D.; Gielesen, W. L. M.; Guilpain, T.; Hernandez, J.; Kirschner, V.; Klioner, S. A.; Koeck, C.; Laine, B.; Lindegren, L.; Serpell, E.; Tatry, P.; Thoral, P.

    2016-07-01

    The Gaia all-sky astrometric survey is challenged by several issues affecting the spacecraft stability. Amongst them, we find the focus evolution, straylight and basic angle variations Contrary to pre-launch expectations, the image quality is continuously evolving, during commissioning and the nominal mission. Payload decontaminations and wavefront sensor assisted refocuses have been carried out to recover optimum performance. An ESA-Airbus DS working group analysed the straylight and basic angle issues and worked on a detailed root cause analysis. In parallel, the Gaia scientists have also analysed the data, most notably comparing the BAM signal to global astrometric solutions, with remarkable agreement. In this contribution, a status review of these issues will be provided, with emphasis on the mitigation schemes and the lessons learned for future space missions where extreme stability is a key requirement.

  3. Ion Beam Extraction by Discrete Ion Focusing

    DEFF Research Database (Denmark)

    2010-01-01

    An apparatus (900) and methods are disclosed for ion beam extraction. In an implementation, the apparatus includes a plasma source (or plasma) (802) and an ion extractor (804). The plasma source is adapted to generate ions and the ion extractor is immersed in the plasma source to extract a fraction...... of the generated ions. The ion extractor is surrounded by a space charge (810) formed at least in part by the extracted ions. The ion extractor includes a biased electrode (806) forming an interface with an insulator (808). The interface is customized to form a strongly curved potential distribution (812......) in the space-charge surrounding the ion extractor. The strongly curved potential distribution focuses the extracted ions towards an opening (814) on a surface of the biased electrode thereby resulting in an ion beam....

  4. Posterior cruciate ligament: focus on conflicting issues.

    Science.gov (United States)

    Lee, Yong Seuk; Jung, Young Bok

    2013-12-01

    There is little consensus on how to optimally reconstruct the posterior cruciate ligament (PCL) and the natural history of injured PCL is also unclear. The graft material (autograft vs. allograft), the type of tibial fixation (tibial inlay vs. transtibial tunnel), the femoral tunnel position within the femoral footprint (isometric, central, or eccentric), and the number of bundles in the reconstruction (1 bundle vs. 2 bundles) are among the many decisions that a surgeon must make in a PCL reconstruction. In addition, there is a paucity of information on rehabilitation after reconstruction of the PCL and posterolateral structures. This article focused on the conflicting issues regarding the PCL, and the scientific rationales behind some critical points are discussed.

  5. Broadening the focus of evaluation: An experiment

    Directory of Open Access Journals (Sweden)

    Chakraborty, S.

    2010-01-01

    Full Text Available Evaluation of student performance in any course, especially those delivered in a management programme, poses a serious challenge; more so, in a course like ‘Business Communication’, where oral communication ought to form an integral part of evaluation. This paper presents various details of an experiment, conducted with a view to introduce this much needed component in the evaluation process. Essential purpose of the exercise was to try and broaden the focus of evaluation, simultaneously enlarging its scope. The need to maintain certain amount of objectivity and transparency was taken as critical. Group Discussion was used as a tool. A process was developed with the objective of getting every student evaluated on both written as well as non-written skills. A two-sided evaluation mechanism was put in place to achieve the dual purpose of leaning and evaluation. Statistical analysis of the results suggests that the experiment was a useful one. The student feedback, too, was favourable.

  6. X-ray focusing using microchannel plates

    Science.gov (United States)

    Kaaret, P.; Geissbuehler, P.; Chen, A.; Glavinas, E.

    1992-01-01

    We present measurements of the X-ray focusing properties of square-pore microchannel plates (MCP's). Square-pore MCP's contain large numbers of closely packed optical surfaces, as required for grazing incidence X-ray optics. The surface of individual MCP channels has been measured and found to have high microroughness transverse to the channel axis and low microroughness parallel to the axis. The high frequency transverse roughness, on length scales greater than 400 nm, has a rms value of 5.9 nm and a Gaussian autocorrelation function with correlation length of 1.41 micron. We find that the geometric misalignments of the surfaces of different channels limit the angular resolution obtainable with current samples of MCP's to 7.1 arcmin.

  7. Preface - Focus Meeting 20: Astronomy for Development

    Science.gov (United States)

    Govender, Kevin

    2016-10-01

    This Focus Meeting was about the global developmental impact that all aspects related to astronomy can deliver. The interdisciplinary nature of the meeting made it relevant to all IAU Divisions and the professional astronomy community in general. The manner in which the strategic plan has been designed and the way in which OAD implements it allows for input and innovation from the professional community both to develop the astronomy field globally and to stimulate the developmental benefits arising from the astronomy field. IAU members have played a key role in every stage of implementation of the strategic plan, from its ratification, through to strong participation in its implementation. This meeting served to report back to them in terms of progress, as well as seek input from them in terms of shaping the way forward.

  8. Radioactive tank waste remediation focus area

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-01

    EM`s Office of Science and Technology has established the Tank Focus Area (TFA) to manage and carry out an integrated national program of technology development for tank waste remediation. The TFA is responsible for the development, testing, evaluation, and deployment of remediation technologies within a system architecture to characterize, retrieve, treat, concentrate, and dispose of radioactive waste stored in the underground stabilize and close the tanks. The goal is to provide safe and cost-effective solutions that are acceptable to both the public and regulators. Within the DOE complex, 335 underground storage tanks have been used to process and store radioactive and chemical mixed waste generated from weapon materials production and manufacturing. Collectively, thes tanks hold over 90 million gallons of high-level and low-level radioactive liquid waste in sludge, saltcake, and as supernate and vapor. Very little has been treated and/or disposed or in final form.

  9. Autoinflammatory Skin Disorders: The Inflammasomme in Focus

    Science.gov (United States)

    Gurung, Prajwal; Kanneganti, Thirumala-Devi

    2016-01-01

    Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders. PMID:27267764

  10. [Strategic focusing of attention during narrative reading].

    Science.gov (United States)

    Hähnel, A; Rinck, M

    1999-01-01

    In 2 experiments based on the constructionist view of text comprehension, we investigated whether readers are able to strategically use, in a problem solving matter, spatial and temporal information that varies in its relevance to the goals of the protagonists. In order to accomplish this, we varied the specificity of the protagonists' goal descriptions. Both experiments consisted of a reading section, a test, and a questionnaire, and differed only in respect to when the questionnaire was administered. The results of both experiments showed that readers were able to use spatial and temporal information of narrative texts in a strategic matter, and they even did so without explicit instruction. This focus of attention, however, was not uniformly reflected in the reading times. Memory data showed a clear disadvantage for temporal information as compared to spatial information. This was the case even though both types of information had been equally well identified in the questionnaire as crucial to the problem solving process of the protagonist.

  11. Review of reasearch and technical development focused

    Directory of Open Access Journals (Sweden)

    Slavkovský Marián

    1998-12-01

    Full Text Available Treatment of flotation tetrahedrite concentrates produced from the of ore mined in the Rudňany and Rožňava ore deposits is a very complex technological problem. This problem has not been solved succesfuly so far. The presence and quality of undesired metal components such as antimony and mercury in the product of a wet ore dressing is a limiting factor for subsequent metalurgical process to obtain pure metal copper and/or silver in copper smelter plants. This factor has been the principal reason of a great effort provided in this respects by both, manufacturers and reaserchers mainly in the last 25 years. This article is focused on the summary of mentioned activities.

  12. Focus on stochastic flows and climate statistics

    Science.gov (United States)

    Marston, JB; Williams, Paul D.

    2016-09-01

    The atmosphere and ocean are examples of dynamical systems that evolve in accordance with the laws of physics. Therefore, climate science is a branch of physics that is just as valid and important as the more traditional branches, which include particle physics, condensed-matter physics, and statistical mechanics. This ‘focus on’ collection of New Journal of Physics brings together original research articles from leading groups that advance our understanding of the physics of climate. Areas of climate science that can particularly benefit from input by physicists are emphasised. The collection brings together articles on stochastic models, turbulence, quasi-linear approximations, climate statistics, statistical mechanics of atmospheres and oceans, jet formation, and reduced-form climate models. The hope is that the issue will encourage more physicists to think about the climate problem.

  13. Focus characteristics of long distance flying optics

    Institute of Scientific and Technical Information of China (English)

    程兆谷; 蒋金波; 李现勤; 许国良; 夏金安; W.M.Steen; G.Dearden

    2000-01-01

    The ABCD law for the complex parameter q of the TEM00 Gaussian beam is generally not valid for high-order modes. It can be used for the high-order modes or their superposition when the spot size w in the virtual part of the parameter q is substituted by the Rayleigh range ZR of a certain resonator. The focus characteristics of long distance flying optics are studied in this paper theoretically and experimentally for the TEMmn Gaussian beams between the two types of resonators without and with distortion. It is very important for the applications of the flying optical processing, the laser space craft and the spatial filter in the large laser project.

  14. Focus on networks, energy and the economy

    Science.gov (United States)

    Timme, Marc; Kocarev, Ljupco; Witthaut, Dirk

    2015-11-01

    A sustainable and reliable energy supply constitutes a fundamental prerequisite for the future of our society. The change to renewable sources comes with several systemic changes and includes, among others, smaller and more distributed producers as well as stronger and less predictable fluctuations. Parallel developments such as the transition from conventional producers and consumers to prosumers and the increasing number of electric vehicles add further complications. These changes require to extend and upgrade currently existing power grids. Yet precisely how to achieve an effective, robustly operating (electric) energy system is far from being understood. This focus issue aims to contribute to a number of these upcoming challenges from the perspective of self-organization and the collective nonlinear dynamics of power grids, interacting economic factors as well as technical restrictions and opportunities for distributed systems.

  15. Focused ultrasound transducer for thermal treatment.

    Science.gov (United States)

    Umemura, Shin-ichiro

    2015-03-01

    Air-backed transducers have been employed for thermal ultrasonic treatment including both ablation and hyperthermia because the power efficiency rather than the bandwidth is a main concern, unlike a typical imaging transducer working in a pulse mode. The characteristic of an air-backed piezoelectric transducer with a matching layer is analysed, and the role and choice of the matching layer is discussed. An element size of a focused array transducer, appropriate for such thermal treatment, is then estimated, and the characteristic of a piezoceramic transducer element of such a size was numerically analysed using a finite element code. The characteristic of a piezocomposite transducer element is also numerically analysed and its suitability to such a therapeutic array transducer is discussed.

  16. Focus Point SUSY at the LHC Revisited

    CERN Document Server

    Das, Siba Prasad; Guchait, Monoranjan; Maity, Manas; Mukherjee, Siddhartha

    2007-01-01

    The estimation of the backgrounds for gluino signals in focus point supersymmetry is extended by including the backgrounds from the production of four third generation quarks in the analysis. We find that these backgrounds are negligible if one uses the strong selection criteria proposed in the literature (including this analysis) for heavy gluino searches. Softer selection criteria often recommended for lighter gluino searches yield backgrounds which are small but numerically significant. We have also repeated the more conventional background calculations and compared our results with the other groups. We find that the size of the total residual background estimated by different groups using different event generators and hard kinematical cuts agree approximately. In view of the theoretical uncertainties in the signal and background cross sections in the leading order mainly due to the choice of the QCD scale the gluino mass reach at the LHC cannot be pinpointed, if the selection criteria requires $\\geq$ 2 t...

  17. Independent focuses Philippines exploration on Visayan basin

    Energy Technology Data Exchange (ETDEWEB)

    Rillera, F.G. [Cophil Exploration Corp., Manila (Philippines)

    1995-08-21

    Cophil Exploration Corp., a Filipino public company, spearheaded 1995 Philippine oil and gas exploration activity with the start of its gas delineation drilling operations in Libertad, northern Cebu. Cophil and its Australian partners, Coplex Resources NL and PacRim Energy NL, have set out to complete a seven well onshore drilling program within this block this year. The companies are testing two modest shallow gas plays, Libertad and Dalingding, and a small oil play, Maya, all in northern Cebu about 500 km southeast of Manila. Following a short discussion on the geology and exploration history of the Visayan basin, this article briefly summarizes Cophil`s ongoing Cebu onshore drilling program. Afterwards, discussion focuses on identified exploration opportunities in the basin`s offshore sector.

  18. Obesity-Related Hypertension: Focus on Leptin

    DEFF Research Database (Denmark)

    Asferg, Camilla Lundegaard

    suggested to play a role in obesity-related hypertension such as the renin-angiotensin-aldosterone system, the sympathetic nervous system, inflammation, insulin resistance, physical inactivity, and abnormal production of adipocytokines. Of all adipocytokines, leptin and adiponectin have received most...... attention and both hormones are considered as candidate intermediaries between adipose tissue and overweight and obesity-related disorders. Objectives: To study obesity-related hypertension with special focus on the hormone leptin. As obesity-related hypertension is multifactorial, other biological systems...... proposed to play a major role were also studied. Primary hypotheses: 1. leptin is a significant mediator of overweight- and obesity-related hypertension. 2. by investigating several biological systems involved in blood pressure regulation, it would be possible to identify specific factors which would...

  19. Interstitial Photodynamic Therapy—A Focused Review

    Science.gov (United States)

    Shafirstein, Gal; Bellnier, David; Oakley, Emily; Hamilton, Sasheen; Potasek, Mary; Beeson, Karl; Parilov, Evgueni

    2017-01-01

    Multiple clinical studies have shown that interstitial photodynamic therapy (I-PDT) is a promising modality in the treatment of locally-advanced cancerous tumors. However, the utilization of I-PDT has been limited to several centers. The objective of this focused review is to highlight the different approaches employed to administer I-PDT with photosensitizers that are either approved or in clinical studies for the treatment of prostate cancer, pancreatic cancer, head and neck cancer, and brain cancer. Our review suggests that I-PDT is a promising treatment in patients with large-volume or thick tumors. Image-based treatment planning and real-time dosimetry are required to optimize and further advance the utilization of I-PDT. In addition, pre- and post-imaging using computed tomography (CT) with contrast may be utilized to assess the response. PMID:28125024

  20. Autoinflammatory Skin Disorders: The Inflammasomme in Focus.

    Science.gov (United States)

    Gurung, Prajwal; Kanneganti, Thirumala-Devi

    2016-07-01

    Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders.