WorldWideScience

Sample records for extremity complex regional

  1. Complex active regions as the main source of extreme and large solar proton events

    Science.gov (United States)

    Ishkov, V. N.

    2013-12-01

    A study of solar proton sources indicated that solar flare events responsible for ≥2000 pfu proton fluxes mostly occur in complex active regions (CARs), i.e., in transition structures between active regions and activity complexes. Different classes of similar structures and their relation to solar proton events (SPEs) and evolution, depending on the origination conditions, are considered. Arguments in favor of the fact that sunspot groups with extreme dimensions are CARs are presented. An analysis of the flare activity in a CAR resulted in the detection of "physical" boundaries, which separate magnetic structures of the same polarity and are responsible for the independent development of each structure.

  2. Intrathecal Bupivacaine Monotherapy with a Retrograde Catheter for the Management of Complex Regional Pain Syndrome of the Lower Extremity.

    Science.gov (United States)

    McRoberts, W Porter; Apostol, Catalina; Haleem, Abdul

    2016-01-01

    Complex regional pain syndrome (CRPS) presents a therapeutic challenge due to its many presentations and multifaceted pathophysiology. There is no approved treatment algorithm and clinical interventions are often applied empirically. In cases of CRPS where symptoms are localized to an extremity, a targeted treatment is indicated. We describe the use of intrathecal bupivacaine monotherapy, delivered through a retrograde catheter, in the treatment of CRPS affecting the lower extremity. The patient, a 57-year-old woman with a history of failed foot surgery, was seen in our office after 2 years of ineffective treatments with local blocks and neurolytic procedures. We advanced therapy to moderately invasive procedures with an emphasis on neuromodulation. A combined central and peripheral stimulation technique that initially provided 75% pain relief, failed to provide lasting analgesia. We proceeded with an intrathecal pump implant. Based on the results of dorsal root ganglion (DRG) mapping, L5-S1 was identified as the optimal target for therapy and a retrograde catheter was placed at this level. Various intrathecal medications were tested individually. An intrathecal morphine trial was ineffective (visual analog scale [VAS] 7), while intrathecal clonidine provided excellent pain relief (VAS 0) that was limited by severe side effects. Bupivacaine provided 100% analgesia with tolerable side effects (lower extremity weakness and minor bladder incontinence) and was selected for intrathecal infusion. After 14 months, bupivacaine treatment continued to control pain exacerbations. We conclude that CRPS patients benefit from early identification of the predominant underlying symptoms and a targeted treatment with moderately invasive techniques when less invasive techniques fail. Intrathecal bupivacaine, bupivacaine monotherapy, retrograde catheter, complex regional pain syndrome (CRPS), dual stimulation, dosal root ganglion (DRG) testing.

  3. Complex regional pain syndrome type I in the upper extremity - how efficient physical therapy and rehabilitation are.

    Science.gov (United States)

    Zečević Luković, Tanja; Ristić, Branko; Jovanović, Zorica; Rančić, Nemanja; Ignjatović Ristić, Dragana; Cuković, Saša

    2012-08-01

    To evaluate the effects of early started combined therapy in Complex Regional Pain Syndrome-1 (CRPS-1) on the upper extremities. The study included 36 patients in the first stadium of CRPS-1 on the upper extremities The mean age of patients was 42.6±14.6, the majority of them (26 of 36) were females. The right side of the upper extremity was affected much more then the left side. They were treated by combined therapy including analgetics, electrotherapy, magneto therapy and kinesitherapy. The average length of observation was 172.1 days (from 90 to 250 days). The average length of treatment was 91.5±42.16 days. Intensity of pain, swelling of the extremity, the change in skin coloration and cutaneous manifestations were assessed three times, at the beginning of the treatment, after 6 weeks and at the end of the treatment. The pain was registered in all patients at visit 1 (average pain intensity was 5.70 ±1.44 on 100 mm visual analogue scale), and it was progressively decreased during the treatment from 3.60±1.22 at the second visit to 0.34±0.68 at the third visit. Vasodilatation was registered in 30 (83.33%) patients and skin temperature asymmetries was found in 21 (58.33%) patients. The difference of size was detected in 30 (83.33%) patients at the first visit compared to four (11.11%) patients at the end of the treatment. There were six (16.66%) patients without swelling at the beginning compared to 26 (72.22%) at the end of the treatment (p less than 0.000). Complete healing was achieved in 32 patients (88.88%). The carefully chosen physical agents in combination with analgesic and non-steroidal anti-inflammatory drugs may benefit in patients with CRPS-1 on the upper extremity if the treatment starts as soon as possible.

  4. Utilization of manual therapy to the lumbar spine in conjunction with traditional conservative care for individuals with bilateral lower extremity complex regional pain syndrome: A case series.

    Science.gov (United States)

    Walston, Zachary; Hernandez, Luis; Yake, Dale

    2018-06-06

    Conservative therapies for complex regional pain syndrome (CRPS) have traditionally focused on exercise and desensitization techniques targeted at the involved extremity. The primary purpose of this case series is to report on the potential benefit of utilizing manual therapy to the lumbar spine in conjunction with traditional conservative care when treating patients with lower extremity CRPS. Two patients with the diagnosis of lower extremity CRPS were treated with manual therapy to the lumbar spine in conjunction with education, exercise, desensitization, and soft tissue techniques for the extremity. Patient 1 received 13 sessions over 6 weeks resulting in a 34-point improvement in oswestry disability index (ODI) and 35-point improvement in lower extremity functional scale (LEFS). Patient 2 received 21 sessions over 12 weeks resulting in a 28-point improvement in ODI and a 41-point improvement in LEFS. Both patients exhibited reductions in pain and clinically meaningful improvements in function. Manual therapies when applied to the lumbar spine in these patients as part of a comprehensive treatment plan resulted in improved spinal mobility, decreased pain, and reduction is distal referred symptoms. Although one cannot infer a cause and effect relationship from a case series, this report identifies meaningful clinical outcomes potentially associated with manual physical therapy to the lumbar spine for two patients with complex regional pain syndrome type 1.

  5. Controlling extreme events on complex networks

    Science.gov (United States)

    Chen, Yu-Zhong; Huang, Zi-Gang; Lai, Ying-Cheng

    2014-08-01

    Extreme events, a type of collective behavior in complex networked dynamical systems, often can have catastrophic consequences. To develop effective strategies to control extreme events is of fundamental importance and practical interest. Utilizing transportation dynamics on complex networks as a prototypical setting, we find that making the network ``mobile'' can effectively suppress extreme events. A striking, resonance-like phenomenon is uncovered, where an optimal degree of mobility exists for which the probability of extreme events is minimized. We derive an analytic theory to understand the mechanism of control at a detailed and quantitative level, and validate the theory numerically. Implications of our finding to current areas such as cybersecurity are discussed.

  6. Wireless peripheral nerve stimulation for complex regional pain syndrome type I of the upper extremity: a case illustration introducing a novel technology.

    Science.gov (United States)

    Herschkowitz, Daniel; Kubias, Jana

    2018-04-13

    Complex regional pain syndrome (CRPS) is a debilitating painful disorder, cryptic in its pathophysiology and refractory condition with limited therapeutic options. Type I CRPS with its variable relationship to trauma has often no discernible fractures or nerve injuries and remains enigmatic in its response to conservative treatment as well as the other limited interventional therapies. Neuromodulation in the form of spinal cord and dorsal root ganglion stimulation (SCS, DRGS) has shown encouraging results, especially of causalgia or CRPS I of lower extremities. Upper extremity CRPS I is far more difficult. To report a case of upper extremity CRPS I treated by wireless peripheral nerve stimulation (WPNS) for its unique features and minimally invasive technique. The system does not involve implantation of battery or its connections. A 47 year old female patient presented with refractory CRPS I following a blunt trauma to her right forearm. As interventional treatment in the form of local anesthetics (Anesthesia of peripheral branches of radial nerve) and combined infusions of ketamine/lidocaine failed to provide any significant relief she opted for WPNS treatment. Based on the topographic distribution, two electrodes (Stimwave Leads: FR4A-RCV-A0 with tines, Generation 1 and FR4A-RCV-B0 with tines, Generation 1), were placed along the course of radial and median nerves under ultrasonography monitoring and guided by intraoperative stimulation. This procedure did not involve implantation of extension cables or the power source. At a frequency of 60 Hz and 300 μs the stimulation induced paresthesia along the distribution of the nerves. Therapeutic relief was observed with high frequency (HF) stimulation (HF 10 kHz/32 μs, 2.0 mA) reducing her pain from a visual analogue scale (VAS) score of 7-4 postoperatively. Three HF stimulations programs were provided at the time of discharge, as she improved in her sensory impairment to touch, pressure and temperature at her first

  7. Complex Plasma Research Under Extreme Conditions

    International Nuclear Information System (INIS)

    Ishihara, Osamu

    2008-01-01

    Complex plasma research under extreme conditions is described. The extreme conditions include low-dimensionality for self-organized structures of dust particles, dust magnetization in high magnetic field, criticality in phase transition, and cryogenic environment for Coulomb crystals and dust dynamics.

  8. Complex Regional Pain Syndrome

    Science.gov (United States)

    Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen ... move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. ...

  9. Modified Graded Motor Imagery for Complex Regional Pain Syndrome Type 1 of the Upper Extremity in the Acute Phase: A Patient Series

    Science.gov (United States)

    Lagueux, Emilie; Charest, Joelle; Lefrancois-Caron, Eve; Mauger, Marie-Eve; Mercier, Emilie; Savard, Kim; Tousignant-Laflamme, Yannick

    2012-01-01

    Complex regional pain syndrome (CRPS) is a pathologic condition in which the painful experience is disproportionate in time and intensity in comparison with the inciting event. At present, the pathophysiology of CRPS is not well understood. Several studies have indicated that cortical reorganization plays a role in the persistence of the symptoms.…

  10. Complex Regional Pain Syndrome and Treatment Approaches

    Directory of Open Access Journals (Sweden)

    Neslihan Gokcen

    2013-08-01

    Full Text Available Complex Regional Pain Syndrome is a symptom complex including severe pain which is disproportioned by the initiating event. Formerly, it was known as reflex sympathetic dystropy, Sudeck’s atrophy and algoneurodystrophy. There are two types of complex regional pain syndrome (CPRS. CRPS type 1 (Reflex sympathetic dystropy occurs after a minor trauma of the extremities, CRPS type 2 (Causalgia occurs following peripheral nevre injury. Diagnosis is made according to the history, symptoms and physical findings of the patients. Patient education, physical therapy and medical treatment are the most common treatment approaches of complex regional pain syndrome. The aim of this review is to revise the treatment options ofcomplex regional pain syndrome, as well as to overview the new treatment approaches and options for the refractory complex regional pain syndrome cases. [Archives Medical Review Journal 2013; 22(4.000: 514-531

  11. Extreme Variables in Star Forming Regions

    Science.gov (United States)

    Contreras Peña, Carlos Eduardo

    2015-01-01

    in two multi-epoch infrared surveys: the UKIDSS Galactic Plane Survey (GPS) and the Vista Variables in the Via Lactea (VVV). In order to further investigate the nature of the selected variable stars, we use photometric information arising from public surveys at near- to far-infrared wavelengths. In addition we have performed spectroscopic and photometric follow-up for a large subset of the samples arising from GPS and VVV. We analyse the widely separated two-epoch K-band photometry in the 5th, 7th and 8th data releases of the UKIDSS Galactic Plane Survey. We find 71 stars with ΔK > 1 mag, including 2 previously known OH/IR stars and a Nova. Even though the mid-plane is mostly excluded from the dataset, we find the majority (66%) of our sample to be within known star forming regions (SFRs), with two large concentrations in the Serpens OB2 association (11 stars) and the Cygnus-X complex (27 stars). The analysis of the multi-epoch K-band photometry of 2010-2012 data from VVV covering the Galactic disc at |b| explained as arising from shock-excited emission caused by molecular outflows. Whether these molecular outflows are related to outbursts events cannot be confirmed from our data. Adding the GPS and VVV spectroscopic results, we find that between 6 and 14 objects are new additions to the FUor class from their close resemblance to the near-infrared spectra of FUors, and at least 23 more objects are new additions to the eruptive variable class. For most of these we are unable to classify them into any of the original definitions for this variable class. In any case, we are adding up to 37 new stars to the eruptive variable class which would double the current number of known objects. We note that most objects are found to be deeply embedded optically invisible stars, thus increasing the number of objects belonging to this subclass by a much larger factor. In general, objects in our samples which are found to be likely eruptive variable stars show a mixture of

  12. Regional tendencies of extreme wind characteristics in Hungary

    Science.gov (United States)

    Radics, Dr.; Bartholy, Dr.; Péliné

    2009-09-01

    Human activities have substantial effects on climate system. It has already accepted that change in the long-term climatic mean state will have significant consequences in the global economy and society, but the most important effects of climate change may come from changes in the intensity and frequency of climatic extremes. It is therefore of great interest to document the extremes of surface wind that could assist in estimating the regional effects of climate change. The research presented is based on 34-year-long (1975-2008) wind (speed, direction, and wind gust) data sets of 36 Hungarian synoptic meteorological stations. After processing (including digitalisation of old instrumental records, quality control and homogenisation of wind time series) the measured wind data sets, time series and complex wind climate analysis were carried out. Spatial and temporal distributions of mean and extreme wind climate characteristics were estimated, wind extremes and trends were interpolated and mapped over the country. Finally, measured and reanalysed (ERA40) wind data were compared over Hungary, in order to verify not only the validity of ERA40 reanalysed data sets, but the adaptability of climate simulation results in estimation of regional climate change effects.

  13. Estimation of extreme risk regions under multivariate regular variation

    NARCIS (Netherlands)

    Cai, J.; Einmahl, J.H.J.; de Haan, L.F.M.

    2011-01-01

    When considering d possibly dependent random variables, one is often interested in extreme risk regions, with very small probability p. We consider risk regions of the form {z ∈ Rd : f (z) ≤ β}, where f is the joint density and β a small number. Estimation of such an extreme risk region is difficult

  14. Complexity in Individual Trajectories toward Online Extremism

    Directory of Open Access Journals (Sweden)

    Z. Cao

    2018-01-01

    Full Text Available Society faces a fundamental global problem of understanding which individuals are currently developing strong support for some extremist entity such as ISIS (Islamic State, even if they never end up doing anything in the real world. The importance of online connectivity in developing intent has been confirmed by recent case studies of already convicted terrorists. Here we use ideas from Complexity to identify dynamical patterns in the online trajectories that individuals take toward developing a high level of extremist support, specifically, for ISIS. Strong memory effects emerge among individuals whose transition is fastest and hence may become “out of the blue” threats in the real world. A generalization of diagrammatic expansion theory helps quantify these characteristics, including the impact of changes in geographical location, and can facilitate prediction of future risks. By quantifying the trajectories that individuals follow on their journey toward expressing high levels of pro-ISIS support—irrespective of whether they then carry out a real-world attack or not—our findings can help move safety debates beyond reliance on static watch-list identifiers such as ethnic background or immigration status and/or postfact interviews with already convicted individuals. Given the broad commonality of social media platforms, our results likely apply quite generally; for example, even on Telegram where (like Twitter there is no built-in group feature as in our study, individuals tend to collectively build and pass through the so-called super-group accounts.

  15. Economics of extreme weather events: Terminology and regional impact models

    OpenAIRE

    Jahn, Malte

    2015-01-01

    Impacts of extreme weather events are relevant for regional (in the sense of subnational) economies and in particular cities in many aspects. Cities are the cores of economic activity and the amount of people and assets endangered by extreme weather events is large, even under the current climate. A changing climate with changing extreme weather patterns and the process of urbanization will make the whole issue even more relevant in the future. In this paper, definitions and terminology in th...

  16. Changes in extreme regional sea level under global warming

    NARCIS (Netherlands)

    Brunnabend, S. E.; Dijkstra, H. A.; Kliphuis, Michael; Bal, Henri E.; Seinstra, Frank J.; van Werkhoven, Ben; Maassen, J.; van Meersbergen, Maarten

    2017-01-01

    An important contribution to future changes in regional sea level extremes is due to the changes in intrinsic ocean variability, in particular ocean eddies. Here, we study a scenario of future dynamic sea level (DSL) extremes using a high-resolution version of the Parallel Ocean Program and

  17. Regional estimation of extreme suspended sediment concentrations using watershed characteristics

    Science.gov (United States)

    Tramblay, Yves; Ouarda, Taha B. M. J.; St-Hilaire, André; Poulin, Jimmy

    2010-01-01

    SummaryThe number of stations monitoring daily suspended sediment concentration (SSC) has been decreasing since the 1980s in North America while suspended sediment is considered as a key variable for water quality. The objective of this study is to test the feasibility of regionalising extreme SSC, i.e. estimating SSC extremes values for ungauged basins. Annual maximum SSC for 72 rivers in Canada and USA were modelled with probability distributions in order to estimate quantiles corresponding to different return periods. Regionalisation techniques, originally developed for flood prediction in ungauged basins, were tested using the climatic, topographic, land cover and soils attributes of the watersheds. Two approaches were compared, using either physiographic characteristics or seasonality of extreme SSC to delineate the regions. Multiple regression models to estimate SSC quantiles as a function of watershed characteristics were built in each region, and compared to a global model including all sites. Regional estimates of SSC quantiles were compared with the local values. Results show that regional estimation of extreme SSC is more efficient than a global regression model including all sites. Groups/regions of stations have been identified, using either the watershed characteristics or the seasonality of occurrence for extreme SSC values providing a method to better describe the extreme events of SSC. The most important variables for predicting extreme SSC are the percentage of clay in the soils, precipitation intensity and forest cover.

  18. Extreme Trust Region Policy Optimization for Active Object Recognition.

    Science.gov (United States)

    Liu, Huaping; Wu, Yupei; Sun, Fuchun; Huaping Liu; Yupei Wu; Fuchun Sun; Sun, Fuchun; Liu, Huaping; Wu, Yupei

    2018-06-01

    In this brief, we develop a deep reinforcement learning method to actively recognize objects by choosing a sequence of actions for an active camera that helps to discriminate between the objects. The method is realized using trust region policy optimization, in which the policy is realized by an extreme learning machine and, therefore, leads to efficient optimization algorithm. The experimental results on the publicly available data set show the advantages of the developed extreme trust region optimization method.

  19. Quantifying China's regional economic complexity

    Science.gov (United States)

    Gao, Jian; Zhou, Tao

    2018-02-01

    China has experienced an outstanding economic expansion during the past decades, however, literature on non-monetary metrics that reveal the status of China's regional economic development are still lacking. In this paper, we fill this gap by quantifying the economic complexity of China's provinces through analyzing 25 years' firm data. First, we estimate the regional economic complexity index (ECI), and show that the overall time evolution of provinces' ECI is relatively stable and slow. Then, after linking ECI to the economic development and the income inequality, we find that the explanatory power of ECI is positive for the former but negative for the latter. Next, we compare different measures of economic diversity and explore their relationships with monetary macroeconomic indicators. Results show that the ECI index and the non-linear iteration based Fitness index are comparative, and they both have stronger explanatory power than other benchmark measures. Further multivariate regressions suggest the robustness of our results after controlling other socioeconomic factors. Our work moves forward a step towards better understanding China's regional economic development and non-monetary macroeconomic indicators.

  20. Predicting extreme rainfall over eastern Asia by using complex networks

    International Nuclear Information System (INIS)

    He Su-Hong; Gong Yan-Chun; Huang Yan-Hua; Wu Cheng-Guo; Feng Tai-Chen; Gong Zhi-Qiang

    2014-01-01

    A climate network of extreme rainfall over eastern Asia is constructed for the period of 1971–2000, employing the tools of complex networks and a measure of nonlinear correlation called event synchronization (ES). Using this network, we predict the extreme rainfall for several cases without delay and with n-day delay (1 ≤ n ≤ 10). The prediction accuracy can reach 58% without delay, 21% with 1-day delay, and 12% with n-day delay (2 ≤ n ≤ 10). The results reveal that the prediction accuracy is low in years of a weak east Asia summer monsoon (EASM) or 1 year later and high in years of a strong EASM or 1 year later. Furthermore, the prediction accuracy is higher due to the many more links that represent correlations between different grid points and a higher extreme rainfall rate during strong EASM years. (geophysics, astronomy, and astrophysics)

  1. Local likelihood estimation of complex tail dependence structures in high dimensions, applied to US precipitation extremes

    KAUST Repository

    Camilo, Daniela Castro

    2017-10-02

    In order to model the complex non-stationary dependence structure of precipitation extremes over the entire contiguous U.S., we propose a flexible local approach based on factor copula models. Our sub-asymptotic spatial modeling framework yields non-trivial tail dependence structures, with a weakening dependence strength as events become more extreme, a feature commonly observed with precipitation data but not accounted for in classical asymptotic extreme-value models. To estimate the local extremal behavior, we fit the proposed model in small regional neighborhoods to high threshold exceedances, under the assumption of local stationarity. This allows us to gain in flexibility, while making inference for such a large and complex dataset feasible. Adopting a local censored likelihood approach, inference is made on a fine spatial grid, and local estimation is performed taking advantage of distributed computing resources and of the embarrassingly parallel nature of this estimation procedure. The local model is efficiently fitted at all grid points, and uncertainty is measured using a block bootstrap procedure. An extensive simulation study shows that our approach is able to adequately capture complex, non-stationary dependencies, while our study of U.S. winter precipitation data reveals interesting differences in local tail structures over space, which has important implications on regional risk assessment of extreme precipitation events. A comparison between past and current data suggests that extremes in certain areas might be slightly wider in extent nowadays than during the first half of the twentieth century.

  2. Local likelihood estimation of complex tail dependence structures in high dimensions, applied to US precipitation extremes

    KAUST Repository

    Camilo, Daniela Castro; Huser, Raphaë l

    2017-01-01

    In order to model the complex non-stationary dependence structure of precipitation extremes over the entire contiguous U.S., we propose a flexible local approach based on factor copula models. Our sub-asymptotic spatial modeling framework yields non-trivial tail dependence structures, with a weakening dependence strength as events become more extreme, a feature commonly observed with precipitation data but not accounted for in classical asymptotic extreme-value models. To estimate the local extremal behavior, we fit the proposed model in small regional neighborhoods to high threshold exceedances, under the assumption of local stationarity. This allows us to gain in flexibility, while making inference for such a large and complex dataset feasible. Adopting a local censored likelihood approach, inference is made on a fine spatial grid, and local estimation is performed taking advantage of distributed computing resources and of the embarrassingly parallel nature of this estimation procedure. The local model is efficiently fitted at all grid points, and uncertainty is measured using a block bootstrap procedure. An extensive simulation study shows that our approach is able to adequately capture complex, non-stationary dependencies, while our study of U.S. winter precipitation data reveals interesting differences in local tail structures over space, which has important implications on regional risk assessment of extreme precipitation events. A comparison between past and current data suggests that extremes in certain areas might be slightly wider in extent nowadays than during the first half of the twentieth century.

  3. Patterns of precipitation and soil moisture extremes in Texas, US: A complex network analysis

    Science.gov (United States)

    Sun, Alexander Y.; Xia, Youlong; Caldwell, Todd G.; Hao, Zengchao

    2018-02-01

    Understanding of the spatial and temporal dynamics of extreme precipitation not only improves prediction skills, but also helps to prioritize hazard mitigation efforts. This study seeks to enhance the understanding of spatiotemporal covariation patterns embedded in precipitation (P) and soil moisture (SM) by using an event-based, complex-network-theoretic approach. Events concurrences are quantified using a nonparametric event synchronization measure, and spatial patterns of hydroclimate variables are analyzed by using several network measures and a community detection algorithm. SM-P coupling is examined using a directional event coincidence analysis measure that takes the order of event occurrences into account. The complex network approach is demonstrated for Texas, US, a region possessing a rich set of hydroclimate features and is frequented by catastrophic flooding. Gridded daily observed P data and simulated SM data are used to create complex networks of P and SM extremes. The uncovered high degree centrality regions and community structures are qualitatively in agreement with the overall existing knowledge of hydroclimate extremes in the study region. Our analyses provide new visual insights on the propagation, connectivity, and synchronicity of P extremes, as well as the SM-P coupling, in this flood-prone region, and can be readily used as a basis for event-driven predictive analytics for other regions.

  4. PDS-Modelling and Regional Bayesian Estimation of Extreme Rainfalls

    DEFF Research Database (Denmark)

    Madsen, Henrik; Rosbjerg, Dan; Harremoës, Poul

    1994-01-01

    rainfalls. The method is applied to two variables: the total precipitation depth and the maximum 10-minute rain intensity of individual storms. On the basis of the atsite modelling a regional analysis is carried out. It is shown that the previous assumption of spatial homogeneity of extreme rainfalls...

  5. Study of Environmental Data Complexity using Extreme Learning Machine

    Science.gov (United States)

    Leuenberger, Michael; Kanevski, Mikhail

    2017-04-01

    The main goals of environmental data science using machine learning algorithm deal, in a broad sense, around the calibration, the prediction and the visualization of hidden relationship between input and output variables. In order to optimize the models and to understand the phenomenon under study, the characterization of the complexity (at different levels) should be taken into account. Therefore, the identification of the linear or non-linear behavior between input and output variables adds valuable information for the knowledge of the phenomenon complexity. The present research highlights and investigates the different issues that can occur when identifying the complexity (linear/non-linear) of environmental data using machine learning algorithm. In particular, the main attention is paid to the description of a self-consistent methodology for the use of Extreme Learning Machines (ELM, Huang et al., 2006), which recently gained a great popularity. By applying two ELM models (with linear and non-linear activation functions) and by comparing their efficiency, quantification of the linearity can be evaluated. The considered approach is accompanied by simulated and real high dimensional and multivariate data case studies. In conclusion, the current challenges and future development in complexity quantification using environmental data mining are discussed. References - Huang, G.-B., Zhu, Q.-Y., Siew, C.-K., 2006. Extreme learning machine: theory and applications. Neurocomputing 70 (1-3), 489-501. - Kanevski, M., Pozdnoukhov, A., Timonin, V., 2009. Machine Learning for Spatial Environmental Data. EPFL Press; Lausanne, Switzerland, p.392. - Leuenberger, M., Kanevski, M., 2015. Extreme Learning Machines for spatial environmental data. Computers and Geosciences 85, 64-73.

  6. Genetic and epidemiological aspect of Complex Regional Pain Syndrome

    NARCIS (Netherlands)

    Rooij, Annetje Monique de

    2010-01-01

    Complex Regional Pain Syndrome (CRPS) is a painful disorder affecting one or more extremities. CRPS is characterized by various combinations of sensory, autonomic and motor disturbances. Genetic factors are suggested to play a role in CRPS, but this has not been extensively studied. Therefore the

  7. Regional Frequency and Uncertainty Analysis of Extreme Precipitation in Bangladesh

    Science.gov (United States)

    Mortuza, M. R.; Demissie, Y.; Li, H. Y.

    2014-12-01

    Increased frequency of extreme precipitations, especially those with multiday durations, are responsible for recent urban floods and associated significant losses of lives and infrastructures in Bangladesh. Reliable and routinely updated estimation of the frequency of occurrence of such extreme precipitation events are thus important for developing up-to-date hydraulic structures and stormwater drainage system that can effectively minimize future risk from similar events. In this study, we have updated the intensity-duration-frequency (IDF) curves for Bangladesh using daily precipitation data from 1961 to 2010 and quantified associated uncertainties. Regional frequency analysis based on L-moments is applied on 1-day, 2-day and 5-day annual maximum precipitation series due to its advantages over at-site estimation. The regional frequency approach pools the information from climatologically similar sites to make reliable estimates of quantiles given that the pooling group is homogeneous and of reasonable size. We have used Region of influence (ROI) approach along with homogeneity measure based on L-moments to identify the homogenous pooling groups for each site. Five 3-parameter distributions (i.e., Generalized Logistic, Generalized Extreme value, Generalized Normal, Pearson Type Three, and Generalized Pareto) are used for a thorough selection of appropriate models that fit the sample data. Uncertainties related to the selection of the distributions and historical data are quantified using the Bayesian Model Averaging and Balanced Bootstrap approaches respectively. The results from this study can be used to update the current design and management of hydraulic structures as well as in exploring spatio-temporal variations of extreme precipitation and associated risk.

  8. Changes of extreme precipitation and nonlinear influence of climate variables over monsoon region in China

    KAUST Repository

    Gao, Tao; Wang, Huixia Judy; Zhou, Tianjun

    2017-01-01

    of precipitation extremes over monsoon regions in China (MRC). However, research on monsoon extremes in China and their associations with climate variables is limited. In this study, we examine the space-time variations of extreme precipitation across the MRC

  9. Data-assisted reduced-order modeling of extreme events in complex dynamical systems.

    Directory of Open Access Journals (Sweden)

    Zhong Yi Wan

    Full Text Available The prediction of extreme events, from avalanches and droughts to tsunamis and epidemics, depends on the formulation and analysis of relevant, complex dynamical systems. Such dynamical systems are characterized by high intrinsic dimensionality with extreme events having the form of rare transitions that are several standard deviations away from the mean. Such systems are not amenable to classical order-reduction methods through projection of the governing equations due to the large intrinsic dimensionality of the underlying attractor as well as the complexity of the transient events. Alternatively, data-driven techniques aim to quantify the dynamics of specific, critical modes by utilizing data-streams and by expanding the dimensionality of the reduced-order model using delayed coordinates. In turn, these methods have major limitations in regions of the phase space with sparse data, which is the case for extreme events. In this work, we develop a novel hybrid framework that complements an imperfect reduced order model, with data-streams that are integrated though a recurrent neural network (RNN architecture. The reduced order model has the form of projected equations into a low-dimensional subspace that still contains important dynamical information about the system and it is expanded by a long short-term memory (LSTM regularization. The LSTM-RNN is trained by analyzing the mismatch between the imperfect model and the data-streams, projected to the reduced-order space. The data-driven model assists the imperfect model in regions where data is available, while for locations where data is sparse the imperfect model still provides a baseline for the prediction of the system state. We assess the developed framework on two challenging prototype systems exhibiting extreme events. We show that the blended approach has improved performance compared with methods that use either data streams or the imperfect model alone. Notably the improvement is more

  10. Data-assisted reduced-order modeling of extreme events in complex dynamical systems.

    Science.gov (United States)

    Wan, Zhong Yi; Vlachas, Pantelis; Koumoutsakos, Petros; Sapsis, Themistoklis

    2018-01-01

    The prediction of extreme events, from avalanches and droughts to tsunamis and epidemics, depends on the formulation and analysis of relevant, complex dynamical systems. Such dynamical systems are characterized by high intrinsic dimensionality with extreme events having the form of rare transitions that are several standard deviations away from the mean. Such systems are not amenable to classical order-reduction methods through projection of the governing equations due to the large intrinsic dimensionality of the underlying attractor as well as the complexity of the transient events. Alternatively, data-driven techniques aim to quantify the dynamics of specific, critical modes by utilizing data-streams and by expanding the dimensionality of the reduced-order model using delayed coordinates. In turn, these methods have major limitations in regions of the phase space with sparse data, which is the case for extreme events. In this work, we develop a novel hybrid framework that complements an imperfect reduced order model, with data-streams that are integrated though a recurrent neural network (RNN) architecture. The reduced order model has the form of projected equations into a low-dimensional subspace that still contains important dynamical information about the system and it is expanded by a long short-term memory (LSTM) regularization. The LSTM-RNN is trained by analyzing the mismatch between the imperfect model and the data-streams, projected to the reduced-order space. The data-driven model assists the imperfect model in regions where data is available, while for locations where data is sparse the imperfect model still provides a baseline for the prediction of the system state. We assess the developed framework on two challenging prototype systems exhibiting extreme events. We show that the blended approach has improved performance compared with methods that use either data streams or the imperfect model alone. Notably the improvement is more significant in

  11. Prediction of extreme floods in the Central Andes by means of Complex Networks

    Science.gov (United States)

    Boers, Niklas; Bookhagen, Bodo; Barbosa, Henrique; Marwan, Norbert; Kurths, Jürgen; Marengo, Jose

    2014-05-01

    Based on a non-linear synchronisation measure and complex network theory, we present a novel framework for the prediction of extreme events of spatially embedded, interrelated time series. This method is general in the sense that it can be applied to any type of spatially sampled time series with significant interrelations, ranging from climate observables to biological or stock market data. In this presentation, we apply our method to extreme rainfall in South America and show how this leads to the prediction of more than 60% (90% during El Niño conditions) of extreme rainfall events in the eastern Central Andes of Bolivia and northern Argentina, with only 1% false alarms. From paleoclimatic to decadal time scales, the Central Andes continue to be subject to pronounced changes in climatic conditions. In particular, our and past work shows that frequency as well as magnitudes of extreme rainfall events have increased significantly during past decades, calling for a better understanding of the involved climatic mechanisms. Due to their large spatial extend and occurrence at high elevations, these extreme events often lead to severe floods and landslides with disastrous socioeconomic impacts. They regularly affect tens of thousands of people and produce estimated costs of the order of several hundred million USD. Alongside with the societal value of predicting natural hazards, our study provides insights into the responsible climatic features and suggests interactions between Rossby waves in polar regions and large scale (sub-)tropical moisture transport as a driver of subseasonal variability of the South American monsoon system. Predictable extreme events result from the propagation of extreme rainfall from the region of Buenos Aires towards the Central Andes given characteristic atmospheric conditions. Our results indicate that the role of frontal systems originating from Rossby waves in polar latitudes is much more dominant for controlling extreme rainfall in

  12. Extreme winds over Europe in the ENSEMBLES regional climate models

    Directory of Open Access Journals (Sweden)

    S. D. Outten

    2013-05-01

    Full Text Available Extreme winds cause vast amounts of damage every year and represent a major concern for numerous industries including construction, afforestation, wind energy and many others. Under a changing climate, the intensity and frequency of extreme events are expected to change, and accurate projections of these changes will be invaluable to decision makers and society as a whole. This work examines four regional climate model downscalings over Europe following the SRES A1B scenario from the "ENSEMBLE-based Predictions of Climate Changes and their Impacts" project (ENSEMBLES. It investigates the projected changes in the 50 yr return wind speeds and the associated uncertainties. This is accomplished by employing the peaks-over-threshold method with the use of the generalised Pareto distribution. The models show that, for much of Europe, the 50 yr return wind is projected to change by less than 2 m s−1, while the uncertainties associated with the statistical estimates are larger than this. In keeping with previous works in this field, the largest source of uncertainty is found to be the inter-model spread, with some locations showing differences in the 50 yr return wind of over 20 m s−1 between two different downscalings.

  13. Complex Regional Pain Syndrome: An inflammatory disease

    NARCIS (Netherlands)

    M. Dirckx (Maaike)

    2015-01-01

    markdownabstractThe pathophysiology of Complex Regional Pain Syndrome (CRPS) is complex and still not completely understood. In addition to a convincing role of inflammation, there are a number of arguments why an involvement of the immune system has been suggested in the pathophysiology of CRPS.

  14. Regional trends in short-duration precipitation extremes: a flexible multivariate monotone quantile regression approach

    Science.gov (United States)

    Cannon, Alex

    2017-04-01

    Estimating historical trends in short-duration rainfall extremes at regional and local scales is challenging due to low signal-to-noise ratios and the limited availability of homogenized observational data. In addition to being of scientific interest, trends in rainfall extremes are of practical importance, as their presence calls into question the stationarity assumptions that underpin traditional engineering and infrastructure design practice. Even with these fundamental challenges, increasingly complex questions are being asked about time series of extremes. For instance, users may not only want to know whether or not rainfall extremes have changed over time, they may also want information on the modulation of trends by large-scale climate modes or on the nonstationarity of trends (e.g., identifying hiatus periods or periods of accelerating positive trends). Efforts have thus been devoted to the development and application of more robust and powerful statistical estimators for regional and local scale trends. While a standard nonparametric method like the regional Mann-Kendall test, which tests for the presence of monotonic trends (i.e., strictly non-decreasing or non-increasing changes), makes fewer assumptions than parametric methods and pools information from stations within a region, it is not designed to visualize detected trends, include information from covariates, or answer questions about the rate of change in trends. As a remedy, monotone quantile regression (MQR) has been developed as a nonparametric alternative that can be used to estimate a common monotonic trend in extremes at multiple stations. Quantile regression makes efficient use of data by directly estimating conditional quantiles based on information from all rainfall data in a region, i.e., without having to precompute the sample quantiles. The MQR method is also flexible and can be used to visualize and analyze the nonlinearity of the detected trend. However, it is fundamentally a

  15. Extreme disorder in an ultrahigh-affinity protein complex

    Science.gov (United States)

    Borgia, Alessandro; Borgia, Madeleine B.; Bugge, Katrine; Kissling, Vera M.; Heidarsson, Pétur O.; Fernandes, Catarina B.; Sottini, Andrea; Soranno, Andrea; Buholzer, Karin J.; Nettels, Daniel; Kragelund, Birthe B.; Best, Robert B.; Schuler, Benjamin

    2018-03-01

    Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these interactions are encoded in the precise complementarity of binding interfaces. Even proteins that are disordered under physiological conditions or that contain large unstructured regions commonly interact with well-structured binding sites on other biomolecules. Here we demonstrate the existence of an unexpected interaction mechanism: the two intrinsically disordered human proteins histone H1 and its nuclear chaperone prothymosin-α associate in a complex with picomolar affinity, but fully retain their structural disorder, long-range flexibility and highly dynamic character. On the basis of closely integrated experiments and molecular simulations, we show that the interaction can be explained by the large opposite net charge of the two proteins, without requiring defined binding sites or interactions between specific individual residues. Proteome-wide sequence analysis suggests that this interaction mechanism may be abundant in eukaryotes.

  16. Extreme disorder in an ultrahigh-affinity protein complex

    DEFF Research Database (Denmark)

    Borgia, Alessandro; Borgia, Madeleine B; Bugge, Katrine

    2018-01-01

    Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these interactions are encoded in the precise complementarity of binding interfaces. Even proteins that are disordered under physiological conditions...... with picomolar affinity, but fully retain their structural disorder, long-range flexibility and highly dynamic character. On the basis of closely integrated experiments and molecular simulations, we show that the interaction can be explained by the large opposite net charge of the two proteins, without requiring...... or that contain large unstructured regions commonly interact with well-structured binding sites on other biomolecules. Here we demonstrate the existence of an unexpected interaction mechanism: the two intrinsically disordered human proteins histone H1 and its nuclear chaperone prothymosin-α associate in a complex...

  17. Defect detection based on extreme edge of defective region histogram

    Directory of Open Access Journals (Sweden)

    Zouhir Wakaf

    2018-01-01

    Full Text Available Automatic thresholding has been used by many applications in image processing and pattern recognition systems. Specific attention was given during inspection for quality control purposes in various industries like steel processing and textile manufacturing. Automatic thresholding problem has been addressed well by the commonly used Otsu method, which provides suitable results for thresholding images based on a histogram of bimodal distribution. However, the Otsu method fails when the histogram is unimodal or close to unimodal. Defects have different shapes and sizes, ranging from very small to large. The gray-level distributions of the image histogram can vary between unimodal and multimodal. Furthermore, Otsu-revised methods, like the valley-emphasis method and the background histogram mode extents, which overcome the drawbacks of the Otsu method, require preprocessing steps and fail to use the general threshold for multimodal defects. This study proposes a new automatic thresholding algorithm based on the acquisition of the defective region histogram and the selection of its extreme edge as the threshold value to segment all defective objects in the foreground from the image background. To evaluate the proposed defect-detection method, common standard images for experimentation were used. Experimental results of the proposed method show that the proposed method outperforms the current methods in terms of defect detection.

  18. Quantifying the Extremity of Windstorms for Regions Featuring Infrequent Events

    Science.gov (United States)

    Walz, M. A.; Leckebusch, G. C.; Kruschke, T.; Rust, H.; Ulbrich, U.

    2017-12-01

    This paper introduces the Distribution-Independent Storm Severity Index (DI-SSI). The DI-SSI represents an approach to quantify the severity of exceptional surface wind speeds of large scale windstorms that is complementary to the Storm Severity Index (SSI) introduced by Leckebusch et al. (2008). While the SSI approaches the extremeness of a storm from a meteorological and potential loss (impact) perspective, the DI-SSI defines the severity in a more climatological perspective. The idea is to assign equal index values to wind speeds of the same singularity (e.g. the 99th percentile) under consideration of the shape of the tail of the local wind speed climatology. Especially in regions at the edge of the classical storm track the DI-SSI shows more equitable severity estimates, e.g. for the extra-tropical cyclone Klaus. Here were compare the integral severity indices for several prominent windstorm in the European domain and discuss the advantages and disadvantages of the respective index. In order to compare the indices, their relation with the North Atlantic Oscillation (NAO) is studied, which is one of the main large scale drivers for the intensity of European windstorms. Additionally we can identify a significant relationship between the frequency and intensity of windstorms for large parts of the European domain.

  19. Spontaneous onset of Complex Regional Pain Syndrome

    NARCIS (Netherlands)

    de Rooij, A.M.; Perez, R.S.G.M.; Huygen, F.J.; van Eijs, F.; van Kleef, M.; Bauer, M.C.R.; van Hilten, J.J.; Marinus, J.

    2010-01-01

    Complex Regional Pain Syndrome (CRPS) usually develops after a noxious event, but spontaneous onsets have been described in 3-11% of the cases. The existence of spontaneous-onset CRPS is highly debated and the aim of the present study was therefore to compare the phenotypic characteristics of CRPS

  20. Exploring regional stakeholder needs and requirements in terms of Extreme Weather Event Attribution

    Science.gov (United States)

    Schwab, M.; Meinke, I.; Vanderlinden, J. P.; Touili, N.; Von Storch, H.

    2015-12-01

    Extreme event attribution has increasingly received attention in the scientific community. It may also serve decision-making at the regional level where much of the climate change impact mitigation takes place. Nevertheless, there is, to date, little known about the requirements of regional actors in terms of extreme event attribution. We have therefore analysed these at the example of regional decision-makers for climate change-related activities and/or concerned with storm surge risks at the German Baltic Sea and heat wave risks in the Greater Paris area. In order to explore if stakeholders find scientific knowledge from extreme event attribution useful and how this information might be relevant to their decision-making, we consulted a diverse set of actors engaged in the assessment, mitigation and communication of storm surge, heat wave, and climate change-related risks. Extreme event attribution knowledge was perceived to be most useful to public and political awareness-raising, but was of little or no relevance for the consulted stakeholders themselves. It was not acknowledged that it would support adaptation planning as sometimes argued in the literature. The consulted coastal protection, health, and urban adaptation planners rather needed reliable statements about possible future changes in extreme events than causal statements about past events. To enhance salience, a suitable product of event attribution should be linked to regional problems, vulnerabilities, and impacts of climate change. Given that the tolerance of uncertainty is rather low, most of the stakeholders also claimed that a suitable product of event attribution is to be received from a trusted "honest broker" and published rather later, but with smaller uncertainties than vice versa. Institutional mechanisms, like regional climate services, which enable and foster communication, translation and mediation across the boundaries between knowledge and action can help fulfill such requirements

  1. COMPLEX REGIONAL PAIN SYNDROME: AN UPDATE

    Directory of Open Access Journals (Sweden)

    Patta

    2015-10-01

    Full Text Available Complex Regional Pain Syndrome or CRPS is a chronic disabling heterogenous pain disorder due to trauma, resulting in sensory changes, motor function impairment, psychological changes. Diagnosis is based on clinical features and investigations. The patho - physiology is not clearly known. There is no single drug therapy, only combinations work. Treatment is multidisplinary involving medical, psychological and rehabi li tation. Newer modes of spinal cord stimulations, neuraxial mode of analgesics and newe r drugs are promising

  2. Brain in complex regional pain syndrome

    OpenAIRE

    Hotta, Jaakko

    2017-01-01

    Complex regional pain syndrome (CRPS) causes disabling and severe limb pain that is difficult to treat. The pain typically increases during motor actions, but is present also at rest. The pathophysiology of CRPS is incompletely understood. Some of the symptoms suggest involvement of the central nervous system, and accordingly, patients have been shown to display alterations in, for instance, the primary sensorimotor cortex (SM1) and indications of neuroinflammation. More thorough pathophysiol...

  3. Region Tourist and Recreation Complex Development

    Directory of Open Access Journals (Sweden)

    Elizaveta Oyusovna Tappaskhanova

    2015-06-01

    Full Text Available The subject matter of the research is the tourist and recreation complex of Kabardino-Balkar Republic. The purpose of the work is to provide solutions to problems of the republic tourist and recreation complex development. The results obtained from the study showed that in spite of the fact that in the region’s development certain positive steps are taken, according to the indicators of the tourism and recreation development, the region has not reach the level of the 1990th yet, the possibilities of this major sector of the republic economy remain not demanded. It is highlighted, that the most important factor in the tourist and recreation complex development is its infrastructure condition. It is recommended to use the model of the infrastructure management aimed at providing its effective functioning and development due to formation of interaction system at every power level through a network of the centers of the tourist and recreation complex development. In the article, the need for the use of the innovative approaches for the republic tourist and recreation complex development in the particular development of the new tourist directions are also found. For the purpose to improve the professional training of personnel for the tourism and recreation sphere, the need for a transition to multilevel training of personnel is proved. The main directions of the republic image development on the basis of designing and implementing of the regional program of its image development as the tourist territory and creation of the tourist information center are defined. Realization of all these problems allows to develop a highly effective and competitive tourist and recreation complex in Kabardino-Balkaria.

  4. 454 sequencing reveals extreme complexity of the class II Major Histocompatibility Complex in the collared flycatcher

    Directory of Open Access Journals (Sweden)

    Gustafsson Lars

    2010-12-01

    Full Text Available Abstract Background Because of their functional significance, the Major Histocompatibility Complex (MHC class I and II genes have been the subject of continuous interest in the fields of ecology, evolution and conservation. In some vertebrate groups MHC consists of multiple loci with similar alleles; therefore, the multiple loci must be genotyped simultaneously. In such complex systems, understanding of the evolutionary patterns and their causes has been limited due to challenges posed by genotyping. Results Here we used 454 amplicon sequencing to characterize MHC class IIB exon 2 variation in the collared flycatcher, an important organism in evolutionary and immuno-ecological studies. On the basis of over 152,000 sequencing reads we identified 194 putative alleles in 237 individuals. We found an extreme complexity of the MHC class IIB in the collared flycatchers, with our estimates pointing to the presence of at least nine expressed loci and a large, though difficult to estimate precisely, number of pseudogene loci. Many similar alleles occurred in the pseudogenes indicating either a series of recent duplications or extensive concerted evolution. The expressed alleles showed unambiguous signals of historical selection and the occurrence of apparent interlocus exchange of alleles. Placing the collared flycatcher's MHC sequences in the context of passerine diversity revealed transspecific MHC class II evolution within the Muscicapidae family. Conclusions 454 amplicon sequencing is an effective tool for advancing our understanding of the MHC class II structure and evolutionary patterns in Passeriformes. We found a highly dynamic pattern of evolution of MHC class IIB genes with strong signals of selection and pronounced sequence divergence in expressed genes, in contrast to the apparent sequence homogenization in pseudogenes. We show that next generation sequencing offers a universal, affordable method for the characterization and, in perspective

  5. Peroneal island flap for wound coverage in complex injuries of the lower extremity

    Directory of Open Access Journals (Sweden)

    Fazal A

    2012-01-01

    Full Text Available Akil Fazal1, Haroon-ur-Rashid1, Tahseen Cheema21Section of Orthopedics, Department of Surgery, Aga Khan University, Karachi, Pakistan; 2Department of Orthopedics and Rehabilitation, University of New Mexico, Albuquerque, NM, USABackground: Complex injuries of the lower extremity pose a therapeutic challenge owing to limited availability of local soft tissue for coverage. One option in this region is the pedicled fasciocutaneous flap based on perforators of the peroneal artery. In this case series, we present our experience of the peroneal island pedicled flap for reconstruction of lower extremity wounds.Methods: Records of 18 cases of peroneal island flap admitted consecutively to the Section of Orthopedics at Aga Khan University Hospital from January 1996 to December of 2009 were studied and their outcomes determined.Results: The most common indication for coverage was open wounds due to a road traffic accident (n = 10, followed by burns (n = 3. The most common area exposed was the lower third of the leg followed by the middle third. The tibia was exposed in 11 patients. The flaps ranged in size from 35 cm2 to over 200 cm2. In 13 patients, the flaps healed uneventfully, while in the remaining five there was partial flap necrosis. In four of the latter patients, the residual wound healed with conservative measures only, but the fifth patient required further surgery to achieve acceptable coverage.Conclusion: The peroneal artery flap appears to be a simple, useful, and reliable flap in the armamentarium of the surgeon when planning soft tissue coverage of the lower extremity.Keywords: leg injuries, surgical flaps, lower extremity

  6. New Concepts in Complex Regional Pain Syndrome

    Science.gov (United States)

    Tajerian, Maral; Clark, J David

    2015-01-01

    SYNOPSIS Despite the severe pain and disability associated with Complex Regional Pain Syndrome (CRPS), our lack of understanding of the pathophysiological mechanisms supporting this enigmatic condition prevents the rational design of new therapies, a situation that is frustrating both to the physician and the patient. The following review will highlight some of the mechanisms thought to be involved in the pathophysiology of CRPS in preclinical models and CRPS patients, with the ultimate goal that understanding these mechanisms will lead to the design of efficacious, mechanism-based treatments available to the clinic. PMID:26611388

  7. Adaptation to extreme climate events at a regional scale

    OpenAIRE

    Hoffmann, Christin

    2017-01-01

    A significant increase of the frequency, the intensity and the duration of extreme climate events in Switzerland induces the need to find a strategy to deal with the damages they cause. For more than two decades, mitigation has been the main objective of climate policy. However, due to already high atmospheric carbon concentrations and the inertia of the climate system, climate change is unavoidable to some degree, even if today’s emissions were almost completely cut back. Along with the high...

  8. Extreme sea-level events in coastal regions

    Digital Repository Service at National Institute of Oceanography (India)

    Unnikrishnan, A.S.

    that the outcome of the project has been a code that is capable of predicting correct trends more often (15 out of 20) than the other ‘black box’ codes in operation at various agencies. U. N. SINHA CSIR-Centre for Mathematical Modelling and Computer... of the extreme climate events. Their past trends, future projections and vulnerabi- lity and adaptation to such events are discussed in the report. The report was based on the efforts of both the working groups of the IPCC, WG I, which deals with the science...

  9. Does Nudging Squelch the Extremes in Regional Climate Modeling?

    Science.gov (United States)

    An important question in regional climate downscaling is whether to constrain (nudge) the interior of the limited-area domain toward the larger-scale driving fields. Prior research has demonstrated that interior nudging can increase the skill of regional climate predictions origin...

  10. Orofacial complex regional pain syndrome: pathophysiologic mechanisms and functional MRI.

    Science.gov (United States)

    Lee, Yeon-Hee; Lee, Kyung Mi; Kim, Hyug-Gi; Kang, Soo-Kyung; Auh, Q-Schick; Hong, Jyung-Pyo; Chun, Yang-Hyun

    2017-08-01

    Complex regional pain syndrome (CRPS) is one of the most challenging chronic pain conditions and is characterized by burning pain, allodynia, hyperalgesia, autonomic changes, trophic changes, edema, and functional loss involving mainly the extremities. Until recently, very few reports have been published concerning CRPS involving the orofacial area. We report on a 50-year-old female patient who presented with unbearable pain in all of her teeth and hypersensitivity of the facial skin. She also reported intractable pain in both extremities accompanied by temperature changes and orofacial pain that increased when the other pains were aggravated. In the case of CRPS with trigeminal neuropathic pain, protocols for proper diagnosis and prompt treatment have yet to be established in academia or in the clinical field. We performed functional magnetic resonance imaging for a thorough analysis of the cortical representation of the affected orofacial area immediately before and immediately after isolated light stimulus of the affected hand and foot and concluded that CRPS can be correlated with trigeminal neuropathy in the orofacial area. Furthermore, the patient was treated with carbamazepine administration and stellate ganglion block, which can result in a rapid improvement of pain in the trigeminal region. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. [Complex regional pain syndrome (CRPS) : An update].

    Science.gov (United States)

    Dimova, V; Birklein, F

    2018-04-17

    The acute phase of complex regional pain syndrome (CRPS) is pathophysiologically characterized by an activation of the immune system and its associated inflammatory response. During the course of CRPS, central nervous symptoms like mechanical hyperalgesia, loss of sensation, and body perception disorders develop. Psychological factors such as pain-related anxiety and traumatic events might have a negative effect on the treatment outcome. While the visible inflammatory symptoms improve, the pain often persists. A stage adapted, targeted treatment could improve the prognosis. Effective multidisciplinary treatment includes the following: pharmacotherapy with steroids, bisphosphonates, or dimethylsulfoxide cream (acute phase), and antineuropathic analgesics (all phases); physiotherapy and behavioral therapy for pain-related anxiety and avoidance of movement; and interventional treatment like spinal cord or dorsal root ganglion stimulation if noninvasive options failed.

  12. Projecting changes in regional temperature and precipitation extremes in the United States

    OpenAIRE

    Justin T. Schoof; Scott M. Robeson

    2016-01-01

    Regional and local climate extremes, and their impacts, result from the multifaceted interplay between large-scale climate forcing, local environmental factors (physiography), and societal vulnerability. In this paper, we review historical and projected changes in temperature and precipitation extremes in the United States, with a focus on strengths and weaknesses of (1) commonly used definitions for extremes such as thresholds and percentiles, (2) statistical approaches to quantifying change...

  13. Regional climate change trends and uncertainty analysis using extreme indices: A case study of Hamilton, Canada

    OpenAIRE

    Razavi, Tara; Switzman, Harris; Arain, Altaf; Coulibaly, Paulin

    2016-01-01

    This study aims to provide a deeper understanding of the level of uncertainty associated with the development of extreme weather frequency and intensity indices at the local scale. Several different global climate models, downscaling methods, and emission scenarios were used to develop extreme temperature and precipitation indices at the local scale in the Hamilton region, Ontario, Canada. Uncertainty associated with historical and future trends in extreme indices and future climate projectio...

  14. On Impact Dynamics under Complex or Extreme Conditions

    KAUST Repository

    Kouraytem, Nadia

    2016-11-01

    The impact of a spherical object onto a surface of a liquid, solid or granular material, is a configuration which occurs in numerous industrial and natural phenomena. The resulting dynamics can produce complex outcomes and often occur on very short time-scales. Their study thereby requires high-speed video imaging, as is done herein. This three-part dissertation investigates widely disparate but kindred impact configurations, where the impacting object is a solid steel sphere, or a molten metal droplet. The substrate, on the other hand, is either granular material, a liquid, or solid ice. Therefore both fluid mechanics and thermodynamics play a key role in some of these dynamics. Part I, investigates the penetration depth of a steel sphere which impacts onto a granular bed containing a mixture of grains of two different sizes. The addition of smaller grains within a bed of larger grains can promote a “lubrication” effect and deeper penetration of the sphere. However, there needs to be enough mass fraction of the smaller grains so that they get lodged between the larger grains and are not simply like isolated rattlers inside the voids between the larger grains. This lubrication occurs even though the addition of the small grains increases the overall packing fraction of the bed. We compare the enhanced penetration for the mixtures to a simple interpolative model based on the results for monodispersed media of the constitutive sizes. The strongest lubrication is observed for large irregular shaped Ottawa sand grains, which are seeded with small spherical glass beads. Part II, tackles the topic of a molten metal drop impacting onto a pool of water. When the drop temperature is far above the boiling temperature of water, a continuous vapor layer can form at the interface between the metal and water, in what is called the Leidenfrost phenomenon. This vapor layer can become unstable forming what is called a vapor explosion, which can break up the molten metal drop

  15. Extremal Regions Detection Guided by Maxima of Gradient Magnitude

    DEFF Research Database (Denmark)

    Faraji, Mehdi; Shambezadeh, Jamshid; Nasrollahi, Kamal

    2015-01-01

    boundaries we introduce Maxima of Gradient Magnitudes (MGMs) which are shown to be points that are mostly around the boundaries of the regions. Having found the MGMs, the method obtains a Global Criterion (GC) for each level of the input image which is used to find Extremum Levels (ELs). The found ELs...

  16. Asthma in Patients Climbing to High and Extreme Altitudes in the Tibetan Everest Region

    NARCIS (Netherlands)

    Huismans, Henrike K.; Douma, W. Rob; Kerstjens, Huib A. M.; Renkema, Tineke E. J.

    Objectives: The aim of this study was to investigate the behavior of asthma in patients traveling to high and extreme altitudes. Methods: Twenty-four Dutch patients with mild asthma did a trekking at high and extreme altitudes (up to 6410 m = 21030 ft) in the Tibetan Everest region. Asthma symptoms,

  17. Complex Regional Pain Syndrome (CRPS Type II After Carpal Tunnel Release Surgery: Case Report

    Directory of Open Access Journals (Sweden)

    Hakan Tunç

    2010-08-01

    Full Text Available Summary Complex regional pain syndrome is a chronic syndrome characterised with dystrophic changes and neurovascular disordes of bone and skin of extremities. The most common etiological factors are trauma, ischemic heart disease, cerebral lesions, servical region disorders, infections, and surgical treatments. Carpal tunnel syndrome is the most common compressive neuropaty of the upper extremity. There are various surgical and conservative alternatives in the treatment of carpal tunnel syndrome. Complex regional pain syndrome has been reported as a complication of surgical carpal tunnel release in 2-5% of patients. In this case report clinical characteristics and rehabilitation outcomes of a patient with complex regional pain syndrome after carpal tunnel release surgery is presented. (Osteoporoz Dünyasından 2010;16:41-3

  18. Mapping extreme rainfall in the Northwest Portugal region: statistical analysis and spatial modelling

    Science.gov (United States)

    Santos, Monica; Fragoso, Marcelo

    2010-05-01

    Extreme precipitation events are one of the causes of natural hazards, such as floods and landslides, making its investigation so important, and this research aims to contribute to the study of the extreme rainfall patterns in a Portuguese mountainous area. The study area is centred on the Arcos de Valdevez county, located in the northwest region of Portugal, the rainiest of the country, with more than 3000 mm of annual rainfall at the Peneda-Gerês mountain system. This work focus on two main subjects related with the precipitation variability on the study area. First, a statistical analysis of several precipitation parameters is carried out, using daily data from 17 rain-gauges with a complete record for the 1960-1995 period. This approach aims to evaluate the main spatial contrasts regarding different aspects of the rainfall regime, described by ten parameters and indices of precipitation extremes (e.g. mean annual precipitation, the annual frequency of precipitation days, wet spells durations, maximum daily precipitation, maximum of precipitation in 30 days, number of days with rainfall exceeding 100 mm and estimated maximum daily rainfall for a return period of 100 years). The results show that the highest precipitation amounts (from annual to daily scales) and the higher frequency of very abundant rainfall events occur in the Serra da Peneda and Gerês mountains, opposing to the valleys of the Lima, Minho and Vez rivers, with lower precipitation amounts and less frequent heavy storms. The second purpose of this work is to find a method of mapping extreme rainfall in this mountainous region, investigating the complex influence of the relief (e.g. elevation, topography) on the precipitation patterns, as well others geographical variables (e.g. distance from coast, latitude), applying tested geo-statistical techniques (Goovaerts, 2000; Diodato, 2005). Models of linear regression were applied to evaluate the influence of different geographical variables (altitude

  19. Satellite-Enhanced Regional Downscaling for Applied Studies: Extreme Precipitation Events in Southeastern South America

    Science.gov (United States)

    Nunes, A.; Gomes, G.; Ivanov, V. Y.

    2016-12-01

    Frequently found in southeastern South America during the warm season from October through May, strong and localized precipitation maxima are usually associated with the presence of mesoscale convective complexes (MCCs) travelling across the region. Flashfloods and landslides can be caused by these extremes in precipitation, with damages to the local communities. Heavily populated, southeastern South America hosts many agricultural activities and hydroelectric production. It encompasses one of the most important river basins in South America, the La Plata River Basin. Therefore, insufficient precipitation is equally prejudicial to the region socio-economic activities. MCCs are originated in the warm season of many regions of the world, however South American MCCs are related to the most severe thunderstorms, and have significantly contributed to the precipitation regime. We used the hourly outputs of Satellite-enhanced Regional Downscaling for Applied Studies (SRDAS), developed at the Federal University of Rio de Janeiro in Brazil, in the analysis of the dynamics and physical characteristics of MCCs in South America. SRDAS is the 25-km resolution downscaling of a global reanalysis available from January 1998 through December 2010. The Regional Spectral Model is the SRDAS atmospheric component and assimilates satellite-based precipitation estimates from the NOAA/Climate Prediction Center MORPHing technique global precipitation analyses. In this study, the SRDAS atmospheric and land-surface variables, global reanalysis products, infrared satellite imagery, and the physical retrievals from the Atmospheric Infrared Sounder (AIRS), on board of the NASA's Aqua satellite, were used in the evaluation of the MCCs developed in southeastern South America from 2008 and 2010. Low-level circulations and vertical profiles were analyzed together to establish the relevance of the moisture transport in connection with the upper-troposphere dynamics to the development of those MCCs.

  20. Changes of extreme precipitation and nonlinear influence of climate variables over monsoon region in China

    KAUST Repository

    Gao, Tao

    2017-07-19

    The El Niño-Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), North Atlantic Oscillation (NAO), Atlantic Multidecadal Oscillation (AMO) and Pacific decadal oscillation (PDO) are well understood to be major drivers for the variability of precipitation extremes over monsoon regions in China (MRC). However, research on monsoon extremes in China and their associations with climate variables is limited. In this study, we examine the space-time variations of extreme precipitation across the MRC, and assess the time-varying influences of the climate drivers using Bayesian dynamic linear regression and their combined nonlinear effects through fitting generalized additive models. Results suggest that the central-east and south China is dominated by less frequent but more intense precipitation. Extreme rainfalls show significant positive trends, coupled with a significant decline of dry spells, indicating an increasing chance of occurrence of flood-induced disasters in the MRC during 1960–2014. Majority of the regional indices display some abrupt shifts during the 1990s. The influences of climate variables on monsoon extremes exhibit distinct interannual or interdecadal variations. IOD, ENSO and AMO have strong impacts on monsoon and extreme precipitation, especially during the 1990s, which is generally consistent with the abrupt shifts in precipitation regimes around this period. Moreover, ENSO mainly affects moderate rainfalls and dry spells, while IOD has a more significant impact on precipitation extremes. These findings could be helpful for improving the forecasting of monsoon extremes in China and the evaluations of climate models.

  1. Mannitol as salvage treatment for Complex Regional Pain Syndrome Type I.

    NARCIS (Netherlands)

    Tan, E.C.T.H.; Tacken, M.C.; Groenewoud, J.M.M.; Goor, H. van; Frolke, J.P.M.

    2010-01-01

    INTRODUCTION: Complex Regional Pain Syndrome Type I (CRPS I) is a continuation of symptoms and signs due to a pathological exaggerated reaction in an extremity of the human body after an injury or operation. Although the clinical picture of CRPS I in the majority of patients is well known, the

  2. Mean versus extreme climate in the Mediterranean region and its sensitivity to future global warming conditions

    Energy Technology Data Exchange (ETDEWEB)

    Paeth, H.; Hense, A. [Meteorological Inst., Univ. Bonn (Germany)

    2005-06-01

    The Mediterranean region (MTR) has been supposed to be very sensitive to changes in land surface and atmospheric greenhouse-gas (GHG) concentrations. Particularly, an intensification of climate extremes may be associated with severe socio-economic implications. Here, we present an analysis of climate mean and extreme conditions in this subtropical area based on regional climate model experiments, simulating the present-day and possible future climate. The analysis of extreme values (EVs) is based on the assumption that the extremes of daily precipitation and near-surface temperature are well fitted by the Generalized Pareto distribution (GPD). Return values of extreme daily events are determined using the method of L-moments. Particular emphasis is laid on the evaluation of the return values with respect to the uncertainty range of the estimate as derived from a Monte Carlo sampling approach. During the most recent 25 years the MTR has become dryer in spring but more humid especially in the western part in autumn and winter. At the same time, the whole region has been subject to a substantial warming. The strongest rainfall extremes are simulated in autumn over the Mediterranean Sea around Italy. Temperature extremes are most pronounced over the land masses, especially over northern Africa. Given the large uncertainty of the EV estimate, only 1-year return values are further analysed. During recent decades, statistically significant changes in extremes are only found for temperature. Future climate conditions may come along with a decrease in mean and extreme precipitation during the cold season, whereas an intensification of the hydrological cycle is predicted in summer and autumn. Temperature is predominantly affected over the Iberian Peninsula and the eastern part of the MTR. In many grid boxes, the signals are blurred out due to the large amount of uncertainty in the EV estimate. Thus, a careful analysis is required when making inferences about the future

  3. Inflammation in complex regional pain syndrome

    Science.gov (United States)

    Parkitny, Luke; McAuley, James H.; Di Pietro, Flavia; Stanton, Tasha R.; O’Connell, Neil E.; Marinus, Johan; van Hilten, Jacobus J.

    2013-01-01

    Objectives: We conducted a systematic review of the literature with meta-analysis to determine whether complex regional pain syndrome (CRPS) is associated with a specific inflammatory profile and whether this is dependent on the duration of the condition. Methods: Comprehensive searches of the literature using MEDLINE, Embase, Scopus, Web of Science, and reference lists from published reviews identified articles that measured inflammatory factors in CRPS. Two independent investigators screened titles and abstracts, and performed data extraction and risk of bias assessments. Studies were subgrouped by medium (blood, blister fluid, and CSF) and duration (acute and chronic CRPS). Where possible, meta-analyses of inflammatory factor concentrations were performed and pooled effect sizes were calculated using random-effects models. Results: Twenty-two studies were included in the systematic review and 15 in the meta-analysis. In acute CRPS, the concentrations of interleukin (IL)-8 and soluble tumor necrosis factor receptors I (sTNF-RI) and II (sTNF-RII) were significantly increased in blood. In chronic CRPS, significant increases were found in 1) TNFα, bradykinin, sIL-1RI, IL-1Ra, IL-2, sIL-2Ra, IL-4, IL-7, interferon-γ, monocyte chemoattractant protein-1 (MCP-1), and sRAGE (soluble receptor for advanced glycation end products) in blood; 2) IL-1Ra, MCP-1, MIP-1β, and IL-6 in blister fluid; and 3) IL-1β and IL-6 in CSF. Chronic CRPS was also associated with significantly decreased 1) substance P, sE-selectin, sL-selectin, sP-selectin, and sGP130 in blood; and 2) soluble intercellular adhesion molecule-1 (sICAM-1) in CSF. Most studies failed to meet 3 or more of our quality criteria. Conclusion: CRPS is associated with the presence of a proinflammatory state in the blood, blister fluid, and CSF. Different inflammatory profiles were found for acute and chronic cases. PMID:23267031

  4. Extreme Temperature Exceedances Change more Rapidly Under Future Warming in Regions of non-Gaussian Short Temperature Distribution Tails

    Science.gov (United States)

    Loikith, P. C.; Neelin, J. D.; Meyerson, J.

    2017-12-01

    Regions of shorter-than-Gaussian warm and cold side temperature distribution tails are shown to occur in spatially coherent patterns in the current climate. Under such conditions, warming may be manifested in more complex ways than if the underlying distribution were close to Gaussian. For example, under a uniform warm shift, the simplest prototype for future warming, a location with a short warm side tail would experience a greater increase in extreme warm exceedances compared to if the distribution were Gaussian. Similarly, for a location with a short cold side tail, a uniform warm shift would result in a rapid decrease in extreme cold exceedances. Both scenarios carry major societal and environmental implications including but not limited to negative impacts on human and ecosystem health, agriculture, and the economy. It is therefore important for climate models to be able to realistically reproduce short tails in simulations of historical climate in order to boost confidence in projections of future temperature extremes. Overall, climate models contributing to the fifth phase of the Coupled Model Intercomparison Project capture many of the principal observed regions of short tails. This suggests the underlying dynamics and physics occur on scales resolved by the models, and helps build confidence in model projections of extremes. Furthermore, most GCMs show more rapid changes in exceedances of extreme temperature thresholds in regions of short tails. Results therefore suggest that the shape of the tails of the underlying temperature distribution is an indicator of how rapidly a location will experience changes to extreme temperature occurrence under future warming.

  5. Low Complexity Tail-Biting Trellises for Some Extremal Self-Dual Codes

    OpenAIRE

    Olocco , Grégory; Otmani , Ayoub

    2002-01-01

    International audience; We obtain low complexity tail-biting trellises for some extremal self-dual codes for various lengths and fields such as the [12,6,6] ternary Golay code and a [24,12,8] Hermitian self-dual code over GF(4). These codes are obtained from a particular family of cyclic Tanner graphs called necklace factor graphs.

  6. Shrinking the Synchrotron : Tabletop Extreme Ultraviolet Absorption of Transition-Metal Complexes

    NARCIS (Netherlands)

    Zhang, Kaili; Lin, Ming Fu; Ryland, Elizabeth S.; Verkamp, Max A.; Benke, Kristin; De Groot, Frank M F; Girolami, Gregory S.; Vura-Weis, Josh

    2016-01-01

    We show that the electronic structure of molecular first-row transition-metal complexes can be reliably measured using tabletop high-harmonic XANES at the metal M2,3 edge. Extreme ultraviolet photons in the 50-70 eV energy range probe 3p → 3d transitions, with the same selection rules as soft X-ray

  7. Bilateral complex regional pain syndrome following spinal cord injury and bilateral calcaneus fracture

    Directory of Open Access Journals (Sweden)

    Ahmet Boyacı

    2013-09-01

    Full Text Available Complex regional pain syndrome (CRPS is a disease affectingone or more extremities, characterized by spontaneouspain, allodynia, hyperpathia and hyperalgesia.CRPS is separated into Type 1 and Type 2. CRPS whichdevelops after a nociceptive event is labeled as Type 1and when it develops following peripheral nerve damage,Type 2. Although the pathogenesis is not fully understood,peripheral and central sensitivity are held responsible.Bilateral lower extremity involvement is extremely rare.However, it should be borne in mind that it can develop intraumatic injuries which occur in more than one area anddiagnosis and commencement of a rehabilitation programshould be made in the early period. The case is presentedhere of bilateral Type 1 CRPS developing after incompletespinal cord injury and bilateral calcaneus fracture. JClin Exp Invest 2013; 4 (3: 360-363Key words: complex regional pain syndrome, calcaneusfracture, spinal cord injury

  8. Regional-Scale High-Latitude Extreme Geoelectric Fields Pertaining to Geomagnetically Induced Currents

    Science.gov (United States)

    Pulkkinen, Antti; Bernabeu, Emanuel; Eichner, Jan; Viljanen, Ari; Ngwira, Chigomezyo

    2015-01-01

    Motivated by the needs of the high-voltage power transmission industry, we use data from the high-latitude IMAGE magnetometer array to study characteristics of extreme geoelectric fields at regional scales. We use 10-s resolution data for years 1993-2013, and the fields are characterized using average horizontal geoelectric field amplitudes taken over station groups that span about 500-km distance. We show that geoelectric field structures associated with localized extremes at single stations can be greatly different from structures associated with regionally uniform geoelectric fields, which are well represented by spatial averages over single stations. Visual extrapolation and rigorous extreme value analysis of spatially averaged fields indicate that the expected range for 1-in-100-year extreme events are 3-8 V/km and 3.4-7.1 V/km, respectively. The Quebec reference ground model is used in the calculations.

  9. Demographic Features in Patients with Complex Regional Pain Syndrome

    Directory of Open Access Journals (Sweden)

    Berat Meryem Alkan

    2011-12-01

    Full Text Available Summary Özet Orijinal Araştırma / Original Investigation 77 Aim: Complex regional pain syndrome (CRPS is characterized by pain, vasomotor and sudomotor changes and trophic disturbances. It may develop as a result of trauma, especially extremity fractures and surgery. Although the pathogenesis of CRPS is not exactly clear explained, it has been suggested that central and periferal mechanisms play role and neurogenic inflamatuar and microvasculer functional impairmensts are accompanying to the process. Not all but some of the patients with past trauma or with other possible etiological factors develop CRPS. This suggests the presence of an individual predisposition. In this article, we searched post fractüred CRPS-I patients demographic characteristics, current systemic diseases and symptoms that accompany a CRPS in our records. Materials and Methods: In this retrospective study conducted in Ankara Atatürk Education and Research Hospital, medical records of 356 patients admitted to physical medicine and rehabilitation outpatient clinics with fractures between January 2011 and June 2011 were evaluated and 34 patients diagnosed as CRPS-1 were included in the study. Results: 34 of 356 patients (9.56% with fractures were diagnosed as CRPS-1 in our outpatient clinics. Mean age of the patients was 46.05 years and 10 patients were females (29.4% and 24 patients (70.6% were males. Fractures were in upper extremities in 18 patients (52.9% and in lower extremities in 16 (47.1% patients. Neuropsychiatric disorders and other systemic diseases that may have a role in etiology of CRPS were found in lower rates in medical records of our patients. Conclusion: CRPS does not develop in every patients after travma who has etiologic risk factors, so it reminds that there exists a tendency to CRPS. We have observed that CRPS-1 risk was increased in male patients and in upper extremity fractures. We did not observe any other impertant factor which increases

  10. Assessing Regional Scale Variability in Extreme Value Statistics Under Altered Climate Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Brunsell, Nathaniel [Univ. of Kansas, Lawrence, KS (United States); Mechem, David [Univ. of Kansas, Lawrence, KS (United States); Ma, Chunsheng [Wichita State Univ., KS (United States)

    2015-02-20

    Recent studies have suggested that low-frequency modes of climate variability can significantly influence regional climate. The climatology associated with extreme events has been shown to be particularly sensitive. This has profound implications for droughts, heat waves, and food production. We propose to examine regional climate simulations conducted over the continental United States by applying a recently developed technique which combines wavelet multi–resolution analysis with information theory metrics. This research is motivated by two fundamental questions concerning the spatial and temporal structure of extreme events. These questions are 1) what temporal scales of the extreme value distributions are most sensitive to alteration by low-frequency climate forcings and 2) what is the nature of the spatial structure of variation in these timescales? The primary objective is to assess to what extent information theory metrics can be useful in characterizing the nature of extreme weather phenomena. Specifically, we hypothesize that (1) changes in the nature of extreme events will impact the temporal probability density functions and that information theory metrics will be sensitive these changes and (2) via a wavelet multi–resolution analysis, we will be able to characterize the relative contribution of different timescales on the stochastic nature of extreme events. In order to address these hypotheses, we propose a unique combination of an established regional climate modeling approach and advanced statistical techniques to assess the effects of low-frequency modes on climate extremes over North America. The behavior of climate extremes in RCM simulations for the 20th century will be compared with statistics calculated from the United States Historical Climatology Network (USHCN) and simulations from the North American Regional Climate Change Assessment Program (NARCCAP). This effort will serve to establish the baseline behavior of climate extremes, the

  11. Rethinking the Psychogenic Model of Complex Regional Pain Syndrome: Somatoform Disorders and Complex Regional Pain Syndrome

    Science.gov (United States)

    Hill, Renee J.; Chopra, Pradeep; Richardi, Toni

    2012-01-01

    Abstract Explaining the etiology of Complex Regional Pain Syndrome (CRPS) from the psychogenic model is exceedingly unsophisticated, because neurocognitive deficits, neuroanatomical abnormalities, and distortions in cognitive mapping are features of CRPS pathology. More importantly, many people who have developed CRPS have no history of mental illness. The psychogenic model offers comfort to physicians and mental health practitioners (MHPs) who have difficulty understanding pain maintained by newly uncovered neuro inflammatory processes. With increased education about CRPS through a biopsychosocial perspective, both physicians and MHPs can better diagnose, treat, and manage CRPS symptomatology. PMID:24223338

  12. Schur Stability Regions for Complex Quadratic Polynomials

    Science.gov (United States)

    Cheng, Sui Sun; Huang, Shao Yuan

    2010-01-01

    Given a quadratic polynomial with complex coefficients, necessary and sufficient conditions are found in terms of the coefficients such that all its roots have absolute values less than 1. (Contains 3 figures.)

  13. The extreme solar storm of May 1921: observations and a complex topological model

    Directory of Open Access Journals (Sweden)

    H. Lundstedt

    2015-01-01

    Full Text Available A complex solid torus model was developed in order to be able to study an extreme solar storm, the so-called "Great Storm" or "New York Railroad Storm" of May 1921, when neither high spatial and time resolution magnetic field measurements, solar flare nor coronal mass ejection observations were available. We suggest that a topological change happened in connection with the occurrence of the extreme solar storm. The solar storm caused one of the most severe space weather effects ever.

  14. Climate change scenarios of precipitation extremes in the Carpathian region based on an ENSEMBLE of regional climate models

    Czech Academy of Sciences Publication Activity Database

    Gaál, Ladislav; Beranová, Romana; Hlavčová, K.; Kyselý, Jan

    2014-01-01

    Roč. 2014, č. 943487 (2014), s. 1-14 ISSN 1687-9309 R&D Projects: GA ČR(CZ) GA14-18675S Institutional support: RVO:68378289 Keywords : precipitation extremes * regional climate models * climate change Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 0.946, year: 2014 http://www.hindawi.com/journals/amete/2014/943487/

  15. Embedded star formation in the extended narrow line region of Centaurus A: Extreme mixing observed by MUSE

    Science.gov (United States)

    Santoro, F.; Oonk, J. B. R.; Morganti, R.; Oosterloo, T. A.; Tadhunter, C.

    2016-05-01

    We present a detailed study of the complex ionization structure in a small (~250 pc) extended narrow line region (ENLR) cloud near Centaurus A using the Multi Unit Spectroscopic Explorer. This cloud is located in the so-called outer filament of ionized gas (about 15 kpc from the nucleus) where jet-induced star formation has been suggested to occur by different studies. We find that, despite the small size, a mixture of ionization mechanisms is operating, resulting in considerable complexity in the spatial ionization structure. The area includes two H II regions where star formation is occurring and another location where star formation must have ceased very recently. Interestingly, the extreme Balmer decrement of one of the star forming regions (Hα/Hβobs ~ 6) indicates that it is still heavily embedded in its natal cocoon of gas and dust. At all three locations a continuum counterpart is found with spectra matching those of O/B stars local to Centaurus A. The H II regions are embedded in a larger gas complex which is photoionized by the radiation of the central active galactic nucleus (AGN), but the O/B stars affect the spatial ionization pattern in the ENLR cloud very locally. In particular, in the surroundings of the youngest star forming region, we can isolate a tight mixing sequence in the diagnostic diagram going from gas with ionization due to a pure stellar continuum to gas only photoionized by the AGN. These results emphasize the complexity and the mixture of processes occurring in star forming regions under the influence of an AGN radiation. This is relevant for our understanding of AGN-induced star formation suggested to occur in a number of objects, including this region of Centaurus A. They also illustrate that these young stars influence the gas over only a limited region.

  16. Regional frequency analysis of extreme rainfall in Belgium based on radar estimates

    Directory of Open Access Journals (Sweden)

    E. Goudenhoofdt

    2017-10-01

    Full Text Available In Belgium, only rain gauge time series have been used so far to study extreme rainfall at a given location. In this paper, the potential of a 12-year quantitative precipitation estimation (QPE from a single weather radar is evaluated. For the period 2005–2016, 1 and 24 h rainfall extremes from automatic rain gauges and collocated radar estimates are compared. The peak intensities are fitted to the exponential distribution using regression in Q-Q plots with a threshold rank which minimises the mean squared error. A basic radar product used as reference exhibits unrealistic high extremes and is not suitable for extreme value analysis. For 24 h rainfall extremes, which occur partly in winter, the radar-based QPE needs a bias correction. A few missing events are caused by the wind drift associated with convective cells and strong radar signal attenuation. Differences between radar and gauge rainfall values are caused by spatial and temporal sampling, gauge underestimations and radar errors. Nonetheless the fit to the QPE data is within the confidence interval of the gauge fit, which remains large due to the short study period. A regional frequency analysis for 1 h duration is performed at the locations of four gauges with 1965–2008 records using the spatially independent QPE data in a circle of 20 km. The confidence interval of the radar fit, which is small due to the sample size, contains the gauge fit for the two closest stations from the radar. In Brussels, the radar extremes are significantly higher than the gauge rainfall extremes, but similar to those observed by an automatic gauge during the same period. The extreme statistics exhibit slight variations related to topography. The radar-based extreme value analysis can be extended to other durations.

  17. Complex Regional Pain Syndrome after Transradial Cardiac Catheterization

    Directory of Open Access Journals (Sweden)

    Chih-Jou Lai

    2006-04-01

    Full Text Available Complex regional pain syndrome (CRPS is a disease with unclear pathophysiology. The condition is characterized by pain, soft tissue change, vasomotor change, and even psychosocial disturbance. It may affect the upper more than the lower extremities, and the distal more than the proximal. The trigger factors include carpal tunnel release, Dupuytren's repair, tendon release procedures, knee surgery, crush injury, ankle arthrodesis, amputation, and hip arthroplasty. Rarely, it has been associated with stroke, mastectomy, pregnancy, and osteogenesis imperfecta. Herein, we present a rare case of a patient who was diagnosed with CRPS after transradial cardiac catheterization. CRPS was first diagnosed due to hand swelling, allodynia, paresthesia, and the limited range of motion of interphalangeal, metacarpophalangeal, and wrist joints, with the preceding factor of transradial cardiac catheterization, and was then confirmed by a three-phase bone scan. After intensive physical therapy with hydrotherapy, manual soft tissue release, and occupational therapy for the hand function, there was much improvement in range of motion and hand function. There was no allodynia or painful sensation in the follow-up. After training, the functional status of this patient was adequate for daily activity.

  18. Modulation of extremes in the Atlantic region by modes of climate variability/change: A mechanistic coupled regional model study

    Energy Technology Data Exchange (ETDEWEB)

    Saravanan, Ramalingam [Texas A & M Univ., College Station, TX (United States)

    2015-01-09

    During the course of this project, we have accomplished the following: 1) Explored the parameter space of component models to minimize regional model bias 2) Assessed the impact of air-sea interaction on hurricanes, focusing in particular on the role of the oceanic barrier layer 3) Contributed to the activities of the U.S. CLIVAR Hurricane Working Group 4) Assessed the impact of lateral and lower boundary conditions on extreme flooding events in the U.S. Midwest in regional model simulations 5) Analyzed the concurrent impact of El Niño-Southern Oscillation and Atlantic Meridional Mode on Atlantic Hurricane activity using observations and regional model simulations

  19. An archaeal tRNA-synthetase complex that enhances aminoacylation under extreme conditions

    DEFF Research Database (Denmark)

    Godinic-Mikulcic, Vlatka; Jaric, Jelena; Hausmann, Corinne D

    2011-01-01

    Aminoacyl-tRNA synthetases (aaRSs) play an integral role in protein synthesis, functioning to attach the correct amino acid with its cognate tRNA molecule. AaRSs are known to associate into higher-order multi-aminoacyl-tRNA synthetase complexes (MSC) involved in archaeal and eukaryotic translatio...... of a complex between MtSerRS and MtArgRS provides a means by which methanogenic archaea can optimize an early step in translation under a wide range of extreme environmental conditions....

  20. Climate change scenarios of precipitation extremes in Central Europe from ENSEMBLES regional climate models

    Czech Academy of Sciences Publication Activity Database

    Gaál, Ľ.; Beranová, R.; Hlavčová, K.; Kyselý, Jan

    2014-01-01

    Roč. 2014, č. 943487 (2014), s. 1-14 ISSN 1687-9309 Institutional support: RVO:67179843 ; RVO:68378289 Keywords : precipitation extremes * regional climate models * climate change Subject RIV: EH - Ecology, Behaviour Impact factor: 0.946, year: 2014

  1. Modelling extreme dry spells in the Mediterranean region in connection with atmospheric circulation

    Science.gov (United States)

    Tramblay, Yves; Hertig, Elke

    2018-04-01

    Long droughts periods can affect the Mediterranean region during the winter season, when most of annual precipitation occurs, and consequently have strong impacts on agriculture, groundwater levels and water resources. The goal of this study is to model annual maximum dry spells lengths (AMDSL) that occur during the extended winter season (October to April). The spatial patterns of extreme dry spells and their relationships with large-scale atmospheric circulation were first investigated. Then, AMDSL were modelled using Generalized Extreme Value (GEV) distributions incorporating climatic covariates, to evaluate the dependences of extreme dry spells to synoptic patterns using an analogue approach. The data from a network of 160 rain gauges having daily precipitation measurements between 1960 and 2009 are considered together with the ERA-20C reanalysis of the 20th century to provide atmospheric variables (geopotential heights, humidity, winds). A regional classification of both the occurrence and the duration of AMDSL helped to distinguish three spatially contiguous regions in which the regional distributions were found homogeneous. From composite analysis, significant positive anomalies in geopotential height (Z500) and negative anomalies in zonal wind (U850) and relative and specific humidity (S850, R850) were found to be associated with AMDSL in the three regions and provided the reference to build analogue days. Finally, non-stationary GEV models have been compared, in which the location and scale parameters are related to different atmospheric indices. Results indicates, at the whole Mediterranean scale, that positives anomalies of the North Atlantic Oscillation index and to a lesser extent the Mediterranean Oscillation index are linked to longer extreme dry spells in the majority of stations. For the three regions identified, the frequency of U850 negative anomalies over North Africa is significantly associated with the magnitude of AMDSL. AMDL are also

  2. Assessment of future extreme climate events over the Porto wine Region

    Science.gov (United States)

    Viceto, Carolina; Cardoso, Susana; Marta-Almeida, Martinho; Gorodetskaya, Irina; Rocha, Alfredo

    2017-04-01

    The Douro Demarcated Region (DDR) is a wine region, in the northern Portugal, recognized for the Porto wine, which is responsible for more than 60% of the total value of national wine exportations. Since the viticulture is highly dependent on weather/climate patterns, the global warming is expected to affect the areas suitable to the growth of a certain variety of grape, its production and quality. This highlights the need of regional studies that assess the future climate changes effects in the vineyard, which might allow an early adjustment. We explore future climate change in the DDR region using a high-resolution regional climate model for Weather Research and Forecasting (WRF) forced by the Max Planck Institute Earth System Model - low resolution (MPI-ESM-LR). Two future periods have been simulated using the emission scenario RCP8.5 - for the mid- (2046-2065) and late 21st century (2081-2100) - and compared to a reference period (1986-2005). The RCP8.5 is a "baseline" scenario without any climate mitigation and corresponds to the pathway with the highest greenhouse gas emissions compared to other scenarios developed by the Intergovernmental Panel for Climate Change. Our regional WRF implementation uses three online-nested domains with increasing resolution at a downscaling ratio of three. The coarser domain of 81-km resolution covers part of the North Atlantic Ocean and most of the Europe. The innermost 9-km horizontal resolution domain includes the Iberian Peninsula, a portion of Northern Africa and the adjacent part of the Atlantic Ocean and Mediterranean Sea. Our study uses this 9-km resolution domain and focuses on a confined area, which comprises the DDR. Such dynamical downscaling approach gives an advantage to assess climate effects on the DDR region, where the high horizontal resolution allows including effects of the oceanic coastline, local riverbeds and complex topography. The climatology of the DDR region determines the more suitable wine variety

  3. Projected changes in climate extremes over Qatar and the Arabian Gulf region

    Science.gov (United States)

    Kundeti, K.; Kanikicharla, K. K.; Al sulaiti, M.; Khulaifi, M.; Alboinin, N.; Kito, A.

    2015-12-01

    The climate of the State of Qatar and the adjacent region is dominated by subtropical dry, hot desert climate with low annual rainfall, very high temperatures in summer and a big difference between maximum and minimum temperatures, especially in the inland areas. The coastal areas are influenced by the Arabian Gulf, and have lower maximum, but higher minimum temperatures and a higher moisture percentage in the air. The global warming can have profound impact on the mean climate as well as extreme weather events over the Arabian Peninsula that may affect both natural and human systems significantly. Therefore, it is important to assess the future changes in the seasonal/annual mean of temperature and precipitation and also the extremes in temperature and wind events for a country like Qatar. This study assesses the performance of the Coupled Model Inter comparison Project Phase 5 (CMIP5) simulations in present and develops future climate scenarios. The changes in climate extremes are assessed for three future periods 2016-2035, 2046-2065 and 2080-2099 with respect to 1986-2005 (base line) under two RCPs (Representative Concentrate Pathways) - RCP4.5 and RCP8.5. We analyzed the projected changes in temperature and precipitation extremes using several indices including those that capture heat stress. The observations show an increase in warm extremes over many parts in this region that are generally well captured by the models. The results indicate a significant change in frequency and intensity of both temperature and precipitation extremes over many parts of this region which may have serious implications on human health, water resources and the onshore/offshore infrastructure in this region. Data from a high-resolution (20km) AGCM simulation from Meteorological Research Institute of Japan Meteorological Agency for the present (1979-2003) and a future time slice (2075-2099) corresponding to RCP8.5 have also been utilized to assess the impact of climate change on

  4. Complex regional pain syndrome type 1 mimicking Raynaud’s phenomenon

    Directory of Open Access Journals (Sweden)

    Serpil Tuna

    2014-09-01

    Full Text Available Complex regional pain syndrome type 1 (CRPS-1 is a chronic pain syndrome characterized by severe pain, swelling, autonomic dysfunction and dystrophic changes in affected extremity. RSDS is a rare disease in children and usually occurs after trauma, however, without trauma may also occur. We were detected CRPS-1 activated by cold and stress and characterized by recurrent attacks in the bilateral upper extremities in 14 year-old girl, which is similar to Raynaud’s phenomenon. We present this case with the literature because of its rarity and atypical course.

  5. Wave-mixing with high-order harmonics in extreme ultraviolet region

    International Nuclear Information System (INIS)

    Dao, Lap Van; Dinh, Khuong Ba; Le, Hoang Vu; Gaffney, Naylyn; Hannaford, Peter

    2015-01-01

    We report studies of the wave-mixing process in the extreme ultraviolet region with two near-infrared driving and controlling pulses with incommensurate frequencies (at 1400 nm and 800 nm). A non-collinear scheme for the two beams is used in order to spatially separate and to characterise the properties of the high-order wave-mixing field. We show that the extreme ultraviolet frequency mixing can be treated by perturbative, very high-order nonlinear optics; the modification of the wave-packet of the free electron needs to be considered in this process

  6. The use of historical information for regional frequency analysis of extreme skew surge

    Science.gov (United States)

    Frau, Roberto; Andreewsky, Marc; Bernardara, Pietro

    2018-03-01

    The design of effective coastal protections requires an adequate estimation of the annual occurrence probability of rare events associated with a return period up to 103 years. Regional frequency analysis (RFA) has been proven to be an applicable way to estimate extreme events by sorting regional data into large and spatially distributed datasets. Nowadays, historical data are available to provide new insight on past event estimation. The utilisation of historical information would increase the precision and the reliability of regional extreme's quantile estimation. However, historical data are from significant extreme events that are not recorded by tide gauge. They usually look like isolated data and they are different from continuous data from systematic measurements of tide gauges. This makes the definition of the duration of our observations period complicated. However, the duration of the observation period is crucial for the frequency estimation of extreme occurrences. For this reason, we introduced here the concept of credible duration. The proposed RFA method (hereinafter referenced as FAB, from the name of the authors) allows the use of historical data together with systematic data, which is a result of the use of the credible duration concept.

  7. Daily temperature and precipitation extremes in the Baltic Sea region derived from the BaltAn65+ reanalysis

    Science.gov (United States)

    Toll, Velle; Post, Piia

    2018-04-01

    Daily 2-m temperature and precipitation extremes in the Baltic Sea region for the time period of 1965-2005 is studied based on data from the BaltAn65 + high resolution atmospheric reanalysis. Moreover, the ability of regional reanalysis to capture extremes is analysed by comparing the reanalysis data to gridded observations. The shortcomings in the simulation of the minimum temperatures over the northern part of the region and in the simulation of the extreme precipitation over the Scandinavian mountains in the BaltAn65+ reanalysis data are detected and analysed. Temporal trends in the temperature and precipitation extremes in the Baltic Sea region, with the largest increases in temperature and precipitation in winter, are detected based on both gridded observations and the BaltAn65+ reanalysis data. However, the reanalysis is not able to capture all of the regional trends in the extremes in the observations due to the shortcomings in the simulation of the extremes.

  8. Environmental management on the basis of Complex Regional Indicators Concept: case of the Murmansk region

    Science.gov (United States)

    Kozlov, A.; Gutman, S.; Zaychenko, I.; Rytova, E.; Nijinskaya, P.

    2015-09-01

    The article presents an approach to sustainable environmental development of the Murmansk region of the Russian Federation based on the complex regional indicators as a transformation of a balance scorecard method. The peculiarities of Murmansk region connected with sustainable environmental development are described. The complex regional indicators approach allows to elaborate the general concept of complex regional development taking into consideration economic and non-economic factors with the focus on environmental aspects, accumulated environmental damage in particular. General strategic chart of sustainable environmental development of the Murmansk region worked out on the basis of complex regional indicators concept is composed. The key target indicators of sustainable ecological development of the Murmansk region are presented for the following strategic chart components: regional finance; society and market; industry and entrepreneurship; training, development and innovations. These charts are to be integrated with international environmental monitoring systems.

  9. Comparing regional precipitation and temperature extremes in climate model and reanalysis products

    Directory of Open Access Journals (Sweden)

    Oliver Angélil

    2016-09-01

    Full Text Available A growing field of research aims to characterise the contribution of anthropogenic emissions to the likelihood of extreme weather and climate events. These analyses can be sensitive to the shapes of the tails of simulated distributions. If tails are found to be unrealistically short or long, the anthropogenic signal emerges more or less clearly, respectively, from the noise of possible weather. Here we compare the chance of daily land-surface precipitation and near-surface temperature extremes generated by three Atmospheric Global Climate Models typically used for event attribution, with distributions from six reanalysis products. The likelihoods of extremes are compared for area-averages over grid cell and regional sized spatial domains. Results suggest a bias favouring overly strong attribution estimates for hot and cold events over many regions of Africa and Australia, and a bias favouring overly weak attribution estimates over regions of North America and Asia. For rainfall, results are more sensitive to geographic location. Although the three models show similar results over many regions, they do disagree over others. Equally, results highlight the discrepancy amongst reanalyses products. This emphasises the importance of using multiple reanalysis and/or observation products, as well as multiple models in event attribution studies.

  10. Regional cerebral blood flow patterns in extremely elderly patients with Alzheimer's disease

    International Nuclear Information System (INIS)

    Hirao, Kentaro; Hanyu, Haruo; Kanetaka, Hidekazu; Shimizu, Soichiro; Sato, Tomohiko; Iwamoto, Toshihiko

    2008-01-01

    Clinical and pathologic features in Alzheimer's disease (AD) patients differ depending on the age of onset. The aim of our study was to compare the regional cerebral blood flow (rCBF) patterns of younger, elderly, and extremely elderly patients with AD with that of controls to characterize the rCBF patterns in extremely elderly patients with AD. Single photon emission CT (SPECT) was performed in 113 patients with probable AD, including 34 younger (<70 years), 41 elderly (70-84 years), and 38 extremely elderly (≥85 years) patients divided according to age at examination. The SPECT data were analyzed using three-dimensional stereotactic surface projection (3D-SSP). No significant differences regarding gender, duration of disease, education, and Mini-Mental State Examination score were found among the groups. As compared with controls, younger and elderly AD demonstrated significant reduction of rCBF in the temporo-parietal areas, posterior cingulate cortices and precunei, which is considered to be a characteristic rCBF pattern in AD. On the other hand, the extremely elderly AD group demonstrated significant reduction of rCBF in the frontal and medial temporal areas, in addition to the temporo-parietal areas, posterior cingulate cortices and precunei, but the reductions were milder than in those in younger and elderly AD groups. The extremely elderly patients with AD showed atypical rCBF patterns in AD compared to younger and elderly patients with AD. Our data suggest that pathological features in extremely elderly AD may be different from those in younger and elderly AD and that diseases different from AD, such as senile dementia of the neurofibrillary tangle type may be clinically diagnosed as extremely elderly AD. (author)

  11. Land use/cover changes, extreme events and ecohydrological responses in the Himalayan region

    Science.gov (United States)

    Singh, R. B.

    1998-10-01

    Land use describes human activities on the earth, and forms a major element of the terrestrial ecosystem modified by humans in the Himalayan region, where developmental activities are increasing rapidly to support the tourism infrastructure. The unprecedented growth in population is putting extremely high pressure on the limited land available for cultivation. Land use and agricultural practices have undergone drastic changes since the mid-1960s through the introduction of development programmes and the application of various newly developed techniques in agrosciences. An analysis of the land use as it has occurred over the last 70 years suggests that it and property rights in the Upper Beas Basin are complex and dynamic. For example, people are giving importance to orchards because of their high profitability. Thus, some agricultural land has been encroached on by orchards. In addition, wastelands are now being used by people for orchards, agriculture and residential and commercial building. Since the Upper Beas River Basin is mountainous, it is fragile and prone to processes like soil erosion, slope instability, landslides and floods. Risks from natural hazards are increasing. However, the state of ecohydrological responses highlight that human-induced ecological changes can be largely proved at the microwatershed level. The findings are not extended to the Himalayan scale. There is also an uncertain correlation between anthropogenic activities (deforestation) in the mountains and hazards in the plains such as floods. Owing to a lack of basic research, there is little effective information which cannot be used for long-term effective monitoring of ecological and hydrological responses to global change. Such an uncertain situation calls for integrated watershed management and development using geographical information systems (GISs).

  12. Complex Socio-Ecological Dynamics driven by extreme events in the Amazon

    Science.gov (United States)

    Pinho, P. F.

    2015-12-01

    Several years with extreme floods or droughts in the past decade have caused human suffering in remote communities of the Brazilian Amazon. Despite documented local knowledge and practices for coping with the high seasonal variability characteristic of the region's hydrology (e.g. 10m change in river levels between dry and flood seasons), and despite 'civil Defense' interventions by various levels of government, the more extreme years seem to have exceeded the coping capacity of the community. In this paper, we explore whether there is a real increase in variability, whether the community perceives that recent extreme events are outside the experience which shapes their responses to 'normal' levels of variability, and what science-based policy could contribute to greater local resilience. Hydrological analyses suggest that variability is indeed increasing, in line with expectations from future climate change. However, current measures of hydrological regimes do not predict years with social hardship very well. Interviewees in two regions are able to express their strategies for dealing with 'normal' variability very well, but also identify ways in which abnormal years exceed their ability to cope. Current Civil Defense arrangements struggle to deliver emergency assistance in a sufficiently timely and locally appropriate fashion. Combining these insights in the context of social-ecological change, we suggest how better integration of science, policy and local knowledge could improve resilience to future trends, and identify some contributions science could make into such an arrangement.

  13. Tourniquet Deflation Prior to 20 Minutes in Upper Extremity Intravenous Regional Anesthesia.

    Science.gov (United States)

    Gurich, Richard W; Langan, Justin W; Teasdall, Robert J; Tanner, Stephanie L; Sanders, John L

    2018-03-01

    Bier blocks, or intravenous regional anesthesia (IVRA), are a method of anesthesia for upper extremity surgeries. This study reports our experience with tourniquet deflation prior to 20 minutes with upper extremity IVRA. This study was designed as a retrospective cohort analysis. Records, including intraoperative and immediate postoperative anesthesia notes, of 430 patients who underwent IVRA with an upper extremity Bier block and a corresponding tourniquet time of less than 20 minutes were reviewed. Patient demographics, procedure(s) performed, American Society of Anesthesiologists scores, volume of lidocaine used in Bier block, tourniquet time, and any complications were recorded. This cohort consisted of 127 males and 303 females. The 3 most common procedures performed were carpal tunnel release (315), trigger finger release (47), and excision of masses (34). The average tourniquet time for this cohort was 16 minutes (range, 9-19 minutes), and the average volume of lidocaine (0.5% plain) injected was 44 mL (range, 30-70 mL). A tourniquet time of 17 minutes or less was observed in 339 patients, and 170 patients had tourniquet times of 15 minutes or less. Five complications were recorded: intraoperative vomiting, mild postoperative nausea/vomiting, severe postoperative nausea and vomiting, and transient postoperative hypotension that responded to a fluid bolus. No major complications were observed in our cohort of upper extremity IVRA and tourniquet times of less than 20 minutes. Several variables play a role in the safety of upper extremity IVRA.

  14. Cyclones and extreme windstorm events over Europe under climate change: Global and regional climate model diagnostics

    Science.gov (United States)

    Leckebusch, G. C.; Ulbrich, U.

    2003-04-01

    More than any changes of the climate system mean state conditions, the development of extreme events may influence social, economic and legal aspects of our society. This linkage results from the impact of extreme climate events (natural hazards) on environmental systems which again are directly linked to human activities. Prominent examples from the recent past are the record breaking rainfall amounts of August 2002 in central Europe which produced widespread floodings or the wind storm Lothar of December 1999. Within the MICE (Modelling the Impact of Climate Extremes) project framework an assessment of the impact of changes in extremes will be done. The investigation is carried out for several different impact categories as agriculture, energy use and property damage. Focus is laid on the diagnostics of GCM and RCM simulations under different climate change scenarios. In this study we concentrate on extreme windstorms and their relationship to cyclone activity in the global HADCM3 as well as in the regional HADRM3 model under two climate change scenarios (SRESA2a, B2a). In order to identify cyclones we used an objective algorithm from Murry and Simmonds which was widely tested under several different conditions. A slight increase in the occurrence of systems is identified above northern parts of central Europe for both scenarios. For more severe systems (core pressure Spain) a shift to more deep cyclones connected with an increasing number of strong wind events is found.

  15. Can Regional Climate Models be used in the assessment of vulnerability and risk caused by extreme events?

    Science.gov (United States)

    Nunes, Ana

    2015-04-01

    Extreme meteorological events played an important role in catastrophic occurrences observed in the past over densely populated areas in Brazil. This motived the proposal of an integrated system for analysis and assessment of vulnerability and risk caused by extreme events in urban areas that are particularly affected by complex topography. That requires a multi-scale approach, which is centered on a regional modeling system, consisting of a regional (spectral) climate model coupled to a land-surface scheme. This regional modeling system employs a boundary forcing method based on scale-selective bias correction and assimilation of satellite-based precipitation estimates. Scale-selective bias correction is a method similar to the spectral nudging technique for dynamical downscaling that allows internal modes to develop in agreement with the large-scale features, while the precipitation assimilation procedure improves the modeled deep-convection and drives the land-surface scheme variables. Here, the scale-selective bias correction acts only on the rotational part of the wind field, letting the precipitation assimilation procedure to correct moisture convergence, in order to reconstruct South American current climate within the South American Hydroclimate Reconstruction Project. The hydroclimate reconstruction outputs might eventually produce improved initial conditions for high-resolution numerical integrations in metropolitan regions, generating more reliable short-term precipitation predictions, and providing accurate hidrometeorological variables to higher resolution geomorphological models. Better representation of deep-convection from intermediate scales is relevant when the resolution of the regional modeling system is refined by any method to meet the scale of geomorphological dynamic models of stability and mass movement, assisting in the assessment of risk areas and estimation of terrain stability over complex topography. The reconstruction of past extreme

  16. Extreme temperature events on Greenland in observations and the MAR regional climate model

    Science.gov (United States)

    Leeson, Amber A.; Eastoe, Emma; Fettweis, Xavier

    2018-03-01

    Meltwater from the Greenland Ice Sheet contributed 1.7-6.12 mm to global sea level between 1993 and 2010 and is expected to contribute 20-110 mm to future sea level rise by 2100. These estimates were produced by regional climate models (RCMs) which are known to be robust at the ice sheet scale but occasionally miss regional- and local-scale climate variability (e.g. Leeson et al., 2017; Medley et al., 2013). To date, the fidelity of these models in the context of short-period variability in time (i.e. intra-seasonal) has not been fully assessed, for example their ability to simulate extreme temperature events. We use an event identification algorithm commonly used in extreme value analysis, together with observations from the Greenland Climate Network (GC-Net), to assess the ability of the MAR (Modèle Atmosphérique Régional) RCM to reproduce observed extreme positive-temperature events at 14 sites around Greenland. We find that MAR is able to accurately simulate the frequency and duration of these events but underestimates their magnitude by more than half a degree Celsius/kelvin, although this bias is much smaller than that exhibited by coarse-scale Era-Interim reanalysis data. As a result, melt energy in MAR output is underestimated by between 16 and 41 % depending on global forcing applied. Further work is needed to precisely determine the drivers of extreme temperature events, and why the model underperforms in this area, but our findings suggest that biases are passed into MAR from boundary forcing data. This is important because these forcings are common between RCMs and their range of predictions of past and future ice sheet melting. We propose that examining extreme events should become a routine part of global and regional climate model evaluation and that addressing shortcomings in this area should be a priority for model development.

  17. Climate Change, Extreme Weather Events, and Human Health Implications in the Asia Pacific Region.

    Science.gov (United States)

    Hashim, Jamal Hisham; Hashim, Zailina

    2016-03-01

    The Asia Pacific region is regarded as the most disaster-prone area of the world. Since 2000, 1.2 billion people have been exposed to hydrometeorological hazards alone through 1215 disaster events. The impacts of climate change on meteorological phenomena and environmental consequences are well documented. However, the impacts on health are more elusive. Nevertheless, climate change is believed to alter weather patterns on the regional scale, giving rise to extreme weather events. The impacts from extreme weather events are definitely more acute and traumatic in nature, leading to deaths and injuries, as well as debilitating and fatal communicable diseases. Extreme weather events include heat waves, cold waves, floods, droughts, hurricanes, tropical cyclones, heavy rain, and snowfalls. Globally, within the 20-year period from 1993 to 2012, more than 530 000 people died as a direct result of almost 15 000 extreme weather events, with losses of more than US$2.5 trillion in purchasing power parity. © 2015 APJPH.

  18. Spatiotemporal distribution characteristics and attribution of extreme regional low temperature event

    International Nuclear Information System (INIS)

    Feng Tai-Chen; Zhang Ke-Quan; Wang Xiao-Juan; Zhang Wen-Yu; Su Hai-Jing; Gong Zhi-Qiang

    2015-01-01

    Based on an objective identification technique for regional low temperature event (OITRLTE), the daily minimum temperature in China has been detected from 1960 to 2013. During this period, there were 60 regional extreme low temperature events (ERLTEs), which are included in the 690 regional low temperature events (RLTEs). The 60 ERLTEs are analyzed in this paper. The results show that in the last 50 years, the intensity of the ERLTEs has become weak; the number of lasted days has decreased; and, the affected area has become small. However, that situation has changed in this century. In terms of spatial distribution, the high intensity regions are mainly in Northern China while the high frequency regions concentrate in Central and Eastern China. According to the affected area of each event, the 60 ERLTEs are classified into six types. The atmospheric circulation background fields which correspond to these types are also analyzed. The results show that, influenced by stronger blocking highs of Ural and Lake Baikal, as well as stronger southward polar vortex and East Asia major trough at 500-hPa geopotential height, cold air from high latitudes is guided to move southward and abnormal northerly winds at 850 hPa makes the cold air blow into China along diverse paths, thereby forming different types of regional extreme low temperatures in winter. (paper)

  19. Model of geophysical fields representation in problems of complex correlation-extreme navigation

    Directory of Open Access Journals (Sweden)

    Volodymyr KHARCHENKO

    2015-09-01

    Full Text Available A model of the optimal representation of spatial data for the task of complex correlation-extreme navigation is developed based on the criterion of minimum deviation of the correlation functions of the original and the resulting fields. Calculations are presented for one-dimensional case using the approximation of the correlation function by Fourier series. It is shown that in the presence of different geophysical map data fields their representation is possible by single template with optimal sampling without distorting the form of the correlation functions.

  20. Characteristics of sub-daily precipitation extremes in observed data and regional climate model simulations

    Czech Academy of Sciences Publication Activity Database

    Beranová, Romana; Kyselý, Jan; Hanel, M.

    2018-01-01

    Roč. 132, 1-2 (2018), s. 515-527 ISSN 0177-798X R&D Projects: GA ČR(CZ) GA14-18675S Institutional support: RVO:68378289 Keywords : sub-daily precipitation * regional climate models * extremes * Czech Republic Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 2.640, year: 2016 https://link.springer.com/article/10.1007/s00704-017-2102-0

  1. Regional amplification of extreme temperatures strongly controlled by soil moisture-temperature feedbacks

    Science.gov (United States)

    Vogel, M.; Orth, R.; Seneviratne, S. I.

    2016-12-01

    Land temperatures, and in particular hot extremes, will likely increase by more than 2° C in many regions, even in the case that the global temperature increase with respect to pre-industrial levels can be limited to 2°C. We investigate here the role of soil moisture-temperature feedbacks for projected changes of extreme temperatures by comparing experiments from the GLACE-CMIP5 (Global Land-Atmosphere Coupling Experiment - Coupled Model Intercomparison Project Phase 5) project. In particular, we consider fully coupled experiments with all 6 involved GCMs and corresponding experiments where soil moisture is fixed to the local present-day seasonal cycle until the end of the 21st century. We consider the yearly hottest days and apply a scaling approach whereby we relate changes of hottest days to global mean temperature increase. We find that soil moisture-temperature coupling significantly contributes to additional future warming of extreme temperatures in many regions: In particular, it can explain more than 70% of the warming amplification of hottest days compared to global mean temperature in Central Europe, Central North America and Northern Australia, and around 50% of this signal in the Amazonian Region and Southern Africa.

  2. The role of regional information in estimation of extreme point rainfalls

    DEFF Research Database (Denmark)

    Rosbjerg, Dan; Madsen, Henrik

    1996-01-01

    Previous analysis has shown that inclusion of regional information improves at-site estimation of point rainfalls and makes it possible to obtain estimates at non-monitored sites. The basis for this analysis was a partial duration series (PDS) modelling of individual rainfall observations and use...... point rainfall data into one sample from a common parent distribution and modelling with disregard of either the dependence between stations or the regional heterogeneity. The different models are analysed and compared with respect to the uncertainty of the predicted extreme events....

  3. Optimizing velocities and transports for complex coastal regions and archipelagos

    OpenAIRE

    Haley, Patrick; Agarwal, Arpit; Lermusiaux, Pierre

    2015-01-01

    We derive and apply a methodology for the initialization of velocity and transport fields in complex multiply-connected regions with multiscale dynamics. The result is initial fields that are consistent with observations, complex geometry and dynamics, and that can simulate the evolution of ocean processes without large spurious initial transients. A class of constrained weighted least squares optimizations is defined to best fit first-guess velocities while satisfying the complex bathymetry,...

  4. Scale dependency of regional climate modeling of current and future climate extremes in Germany

    Science.gov (United States)

    Tölle, Merja H.; Schefczyk, Lukas; Gutjahr, Oliver

    2017-11-01

    A warmer climate is projected for mid-Europe, with less precipitation in summer, but with intensified extremes of precipitation and near-surface temperature. However, the extent and magnitude of such changes are associated with creditable uncertainty because of the limitations of model resolution and parameterizations. Here, we present the results of convection-permitting regional climate model simulations for Germany integrated with the COSMO-CLM using a horizontal grid spacing of 1.3 km, and additional 4.5- and 7-km simulations with convection parameterized. Of particular interest is how the temperature and precipitation fields and their extremes depend on the horizontal resolution for current and future climate conditions. The spatial variability of precipitation increases with resolution because of more realistic orography and physical parameterizations, but values are overestimated in summer and over mountain ridges in all simulations compared to observations. The spatial variability of temperature is improved at a resolution of 1.3 km, but the results are cold-biased, especially in summer. The increase in resolution from 7/4.5 km to 1.3 km is accompanied by less future warming in summer by 1 ∘C. Modeled future precipitation extremes will be more severe, and temperature extremes will not exclusively increase with higher resolution. Although the differences between the resolutions considered (7/4.5 km and 1.3 km) are small, we find that the differences in the changes in extremes are large. High-resolution simulations require further studies, with effective parameterizations and tunings for different topographic regions. Impact models and assessment studies may benefit from such high-resolution model results, but should account for the impact of model resolution on model processes and climate change.

  5. Scaling of precipitation extremes with temperature in the French Mediterranean region: What explains the hook shape?

    Science.gov (United States)

    Drobinski, P.; Alonzo, B.; Bastin, S.; Silva, N. Da; Muller, C.

    2016-04-01

    Expected changes to future extreme precipitation remain a key uncertainty associated with anthropogenic climate change. Extreme precipitation has been proposed to scale with the precipitable water content in the atmosphere. Assuming constant relative humidity, this implies an increase of precipitation extremes at a rate of about 7% °C-1 globally as indicated by the Clausius-Clapeyron relationship. Increases faster and slower than Clausius-Clapeyron have also been reported. In this work, we examine the scaling between precipitation extremes and temperature in the present climate using simulations and measurements from surface weather stations collected in the frame of the HyMeX and MED-CORDEX programs in Southern France. Of particular interest are departures from the Clausius-Clapeyron thermodynamic expectation, their spatial and temporal distribution, and their origin. Looking at the scaling of precipitation extreme with temperature, two regimes emerge which form a hook shape: one at low temperatures (cooler than around 15°C) with rates of increase close to the Clausius-Clapeyron rate and one at high temperatures (warmer than about 15°C) with sub-Clausius-Clapeyron rates and most often negative rates. On average, the region of focus does not seem to exhibit super Clausius-Clapeyron behavior except at some stations, in contrast to earlier studies. Many factors can contribute to departure from Clausius-Clapeyron scaling: time and spatial averaging, choice of scaling temperature (surface versus condensation level), and precipitation efficiency and vertical velocity in updrafts that are not necessarily constant with temperature. But most importantly, the dynamical contribution of orography to precipitation in the fall over this area during the so-called "Cevenoles" events, explains the hook shape of the scaling of precipitation extremes.

  6. Game theory and extremal optimization for community detection in complex dynamic networks.

    Science.gov (United States)

    Lung, Rodica Ioana; Chira, Camelia; Andreica, Anca

    2014-01-01

    The detection of evolving communities in dynamic complex networks is a challenging problem that recently received attention from the research community. Dynamics clearly add another complexity dimension to the difficult task of community detection. Methods should be able to detect changes in the network structure and produce a set of community structures corresponding to different timestamps and reflecting the evolution in time of network data. We propose a novel approach based on game theory elements and extremal optimization to address dynamic communities detection. Thus, the problem is formulated as a mathematical game in which nodes take the role of players that seek to choose a community that maximizes their profit viewed as a fitness function. Numerical results obtained for both synthetic and real-world networks illustrate the competitive performance of this game theoretical approach.

  7. Community detection in complex networks using deep auto-encoded extreme learning machine

    Science.gov (United States)

    Wang, Feifan; Zhang, Baihai; Chai, Senchun; Xia, Yuanqing

    2018-06-01

    Community detection has long been a fascinating topic in complex networks since the community structure usually unveils valuable information of interest. The prevalence and evolution of deep learning and neural networks have been pushing forward the advancement in various research fields and also provide us numerous useful and off the shelf techniques. In this paper, we put the cascaded stacked autoencoders and the unsupervised extreme learning machine (ELM) together in a two-level embedding process and propose a novel community detection algorithm. Extensive comparison experiments in circumstances of both synthetic and real-world networks manifest the advantages of the proposed algorithm. On one hand, it outperforms the k-means clustering in terms of the accuracy and stability thus benefiting from the determinate dimensions of the ELM block and the integration of sparsity restrictions. On the other hand, it endures smaller complexity than the spectral clustering method on account of the shrinkage in time spent on the eigenvalue decomposition procedure.

  8. Estimation of Economic Efficiency of Regional Touristic Complex

    Directory of Open Access Journals (Sweden)

    Kurchenkov Vladimir Viktorovich

    2015-09-01

    Full Text Available The article describes the features of the development of the regional touristic complex in modern conditions and determines the direction of realizing the potential of the regional market of tourist services. The authors reveal the multiplicative interrelation for analyzing the interaction of the primary and secondary sectors of the regional market of tourist services. The key indicators of efficiency are outlined, the extent of their relevance for assessing the potential of international tourism in the region is revealed. The authors calculate the relative indicators reflecting the dynamics of incomes from inbound, outbound and domestic tourism in relation to the total income from tourism activities in the region during the reporting period, usually for one calendar year. On the basis of these parameters, the classification of the regions of the Southern Federal District in terms of tourist attraction is carried out. The authors determine the reasons of the low tourist attractiveness of the Volgograd region in comparison with other regions of the Southern Federal District. It is substantiated that the potential of expanding tourism activity is not fully realized today in the Volgograd region. The technique of analysis and evaluation of the effectiveness of regional touristic complex on the basis of cluster approach is suggested. For analyzing the effectiveness of regional tourism cluster the authors propose to use indicators that reflect the overall performance of the regional tourism cluster, characterizing the impact of cluster development of the area, or the regional market, as well as evaluating the performance of each of the companies cooperating in the framework of the cluster. The article contains recommendations to the regional authorities on improving the efficiency of regional touristic complex in the short- and long-term prospects.

  9. A regional and nonstationary model for partial duration series of extreme rainfall

    DEFF Research Database (Denmark)

    Gregersen, Ida Bülow; Madsen, Henrik; Rosbjerg, Dan

    2017-01-01

    as the explanatory variables in the regional and temporal domain, respectively. Further analysis of partial duration series with nonstationary and regional thresholds shows that the mean exceedances also exhibit a significant variation in space and time for some rainfall durations, while the shape parameter is found...... of extreme rainfall. The framework is built on a partial duration series approach with a nonstationary, regional threshold value. The model is based on generalized linear regression solved by generalized estimation equations. It allows a spatial correlation between the stations in the network and accounts...... furthermore for variable observation periods at each station and in each year. Marginal regional and temporal regression models solved by generalized least squares are used to validate and discuss the results of the full spatiotemporal model. The model is applied on data from a large Danish rain gauge network...

  10. Two centuries of extreme events over the Baltic Sea and North Sea regions

    Science.gov (United States)

    Stendel, Martin; den Besselaar Else, van; Abdel, Hannachi; Jaak, Jaagus; Elizabeth, Kent; Christiana, Lefebvre; Gudrun, Rosenhagen; Anna, Rutgersson; Frederik, Schenk; der Schrier Gerard, van; Tim, Woolings

    2017-04-01

    Two centuries of extreme events over the Baltic Sea and North Sea regions In the framework of the BACC 2 (for the Baltic Sea) and NOSCCA projects (for the North Sea region), studies of past and present variability and changes in atmospheric variables within the North Sea region over the instrumental period (roughly the past 200 years) have been investigated. Findings on trends in temperature and precipitation have already been presented. Here we focus on data homogeneity issues and examine how reliable reanalyses are in this context. Unlike most other regions in the world, there is a wealth of old observations available for the Baltic and North Sea regions, most of it in handwritten form in meteorological journals and other publications. These datasets need to be carefully digitised and homogenized. For this, a thorough quality control must be applied; otherwise the digitised datasets may prove useless or even counterproductive. We present evidence that this step cannot be conducted without human interference and thus cannot be fully automated. Furthermore, inhomogeneities due to e.g. instrumentation and station relocations need to be addressed. A wealth of reanalysis products is available, which can help detect such inhomogeneities in observed time series, but at the same time are prone to biases and/or spurious trends themselves e.g. introduced by changes in the availability and quality of the underlying assimilated data. It therefore in general remains unclear in how far we can simulate the pre-satellite era with respect to homogeneity with reanalyses based only on parts of the observing system. Extreme events and changes in extreme situations are more important and of greater (societal) significance than changes in mean climate. However, changes in extreme weather events are difficult to assess not only because they are, per definition, rare events, but also due to the homogeneity issues outlined above. Taking these into account, we present evidence for changes

  11. Comparison of Extreme Precipitation Return Levels using Spatial Bayesian Hierarchical Modeling versus Regional Frequency Analysis

    Science.gov (United States)

    Love, C. A.; Skahill, B. E.; AghaKouchak, A.; Karlovits, G. S.; England, J. F.; Duren, A. M.

    2017-12-01

    We compare gridded extreme precipitation return levels obtained using spatial Bayesian hierarchical modeling (BHM) with their respective counterparts from a traditional regional frequency analysis (RFA) using the same set of extreme precipitation data. Our study area is the 11,478 square mile Willamette River basin (WRB) located in northwestern Oregon, a major tributary of the Columbia River whose 187 miles long main stem, the Willamette River, flows northward between the Coastal and Cascade Ranges. The WRB contains approximately two ­thirds of Oregon's population and 20 of the 25 most populous cities in the state. The U.S. Army Corps of Engineers (USACE) Portland District operates thirteen dams and extreme precipitation estimates are required to support risk­ informed hydrologic analyses as part of the USACE Dam Safety Program. Our intent is to profile for the USACE an alternate methodology to an RFA that was developed in 2008 due to the lack of an official NOAA Atlas 14 update for the state of Oregon. We analyze 24-hour annual precipitation maxima data for the WRB utilizing the spatial BHM R package "spatial.gev.bma", which has been shown to be efficient in developing coherent maps of extreme precipitation by return level. Our BHM modeling analysis involved application of leave-one-out cross validation (LOO-CV), which not only supported model selection but also a comprehensive assessment of location specific model performance. The LOO-CV results will provide a basis for the BHM RFA comparison.

  12. Expected changes in future temperature extremes and their elevation dependency over the Yellow River source region

    Directory of Open Access Journals (Sweden)

    Y. Hu

    2013-07-01

    Full Text Available Using the Statistical DownScaling Model (SDSM and the outputs from two global climate models, we investigate possible changes in mean and extreme temperature indices and their elevation dependency over the Yellow River source region for the two future periods 2046–2065 and 2081–2100 under the IPCC SRES A2, A1B and B1 emission scenarios. Changes in interannual variability of mean and extreme temperature indices are also analyzed. The validation results show that SDSM performs better in reproducing the maximum temperature-related indices than the minimum temperature-related indices. The projections show that by the middle and end of the 21st century all parts of the study region may experience increases in both mean and extreme temperature in all seasons, along with an increase in the frequency of hot days and warm nights and with a decrease in frost days. By the end of the 21st century, interannual variability increases in all seasons for the frequency of hot days and warm nights and in spring for frost days while it decreases for frost days in summer. Autumn demonstrates pronounced elevation-dependent changes in which around six out of eight indices show significant increasing changes with elevation.

  13. Regional Frequency Analysis of Extreme Dry Spells during Rainy Season in the Wei River Basin, China

    Directory of Open Access Journals (Sweden)

    Dunxian She

    2016-01-01

    Full Text Available Our research analyzes the regional changes of extreme dry spell, represented by the annual maximum dry spell length (noted as AMDSL during the rainy season in the Wei River Basin (WRB of China for 1960–2014 using the L-moments method. The mean AMDSL values increase from the west to the east of the WRB, suggesting a high dry risk in the east compared to the west in the WRB. To investigate the regional frequency more reasonably, the WRB is clustered into four homogenous subregions via the K-means method and some subjective adjustments. The goodness-of-fit test shows that the GEV, PE3, and GLO distribution can be accepted as the “best-fit” model for subregions 1 and 4, subregion 2, and subregion 3, respectively. The quantiles of AMDSL under various return levels figure out a similar spatial distribution with mean AMDSL. We also find that the dry risk in subregion 2 and subregion 4 might be higher than that in subregion 1. The relationship between ENSO events and extreme dry spell events in the rainy season with cross wavelet analysis method proves that ENSO events play a critical role in triggering extreme dry events during rainy season in the WRB.

  14. Evaluation of trends in high temperature extremes in north-western Europe in regional climate models

    International Nuclear Information System (INIS)

    Min, E; Hazeleger, W; Van Oldenborgh, G J; Sterl, A

    2013-01-01

    Projections of future changes in weather extremes on the regional and local scale depend on a realistic representation of trends in extremes in regional climate models (RCMs). We have tested this assumption for moderate high temperature extremes (the annual maximum of the daily maximum 2 m temperature, T ann.max ). Linear trends in T ann.max from historical runs of 14 RCMs driven by atmospheric reanalysis data are compared with trends in gridded station data. The ensemble of RCMs significantly underestimates the observed trends over most of the north-western European land surface. Individual models do not fare much better, with even the best performing models underestimating observed trends over large areas. We argue that the inability of RCMs to reproduce observed trends is probably not due to errors in large-scale circulation. There is also no significant correlation between the RCM T ann.max trends and trends in radiation or Bowen ratio. We conclude that care should be taken when using RCM data for adaptation decisions. (letter)

  15. Ultrasound-Guided Regional Anesthesia for Procedures of the Upper Extremity

    Directory of Open Access Journals (Sweden)

    Farheen Mirza

    2011-01-01

    Full Text Available Anesthesia options for upper extremity surgery include general and regional anesthesia. Brachial plexus blockade has several advantages including decreased hemodynamic instability, avoidance of airway instrumentation, and intra-, as well as post-operative analgesia. Prior to the availability of ultrasound the risks of complications and failure of regional anesthesia made general anesthesia a more desirable option for anesthesiologists inexperienced in the practice of regional anesthesia. Ultrasonography has revolutionized the practice of regional anesthesia. By visualizing needle entry throughout the procedure, the relationship between the anatomical structures and the needle can reduce the incidence of complications. In addition, direct visualization of the spread of local anesthesia around the nerves provides instant feedback regarding the likely success of the block. This review article outlines how ultrasound has improved the safety and success of brachial plexus blocks. The advantages that ultrasound guidance provides are only as good as the experience of the anesthesiologist performing the block. For example, in experienced hands, with real time needle visualization, a supraclavicular brachial plexus block has changed from an approach with the highest risk of pneumothorax to a block with minimal risks making it the ideal choice for most upper extremity surgeries.

  16. Spatiotemporal distribution characteristics and attribution of extreme regional low temperature event

    Science.gov (United States)

    Feng, Tai-Chen; Zhang, Ke-Quan; Su, Hai-Jing; Wang, Xiao-Juan; Gong, Zhi-Qiang; Zhang, Wen-Yu

    2015-10-01

    Based on an objective identification technique for regional low temperature event (OITRLTE), the daily minimum temperature in China has been detected from 1960 to 2013. During this period, there were 60 regional extreme low temperature events (ERLTEs), which are included in the 690 regional low temperature events (RLTEs). The 60 ERLTEs are analyzed in this paper. The results show that in the last 50 years, the intensity of the ERLTEs has become weak; the number of lasted days has decreased; and, the affected area has become small. However, that situation has changed in this century. In terms of spatial distribution, the high intensity regions are mainly in Northern China while the high frequency regions concentrate in Central and Eastern China. According to the affected area of each event, the 60 ERLTEs are classified into six types. The atmospheric circulation background fields which correspond to these types are also analyzed. The results show that, influenced by stronger blocking highs of Ural and Lake Baikal, as well as stronger southward polar vortex and East Asia major trough at 500-hPa geopotential height, cold air from high latitudes is guided to move southward and abnormal northerly winds at 850 hPa makes the cold air blow into China along diverse paths, thereby forming different types of regional extreme low temperatures in winter. Project supported by the National Natural Science Foundation of China (Grant No. 41305075), the National Basic Research Program of China (Grant Nos. 2012CB955203 and 2012CB955902), and the Special Scientific Research on Public Welfare Industry, China (Grant No. GYHY201306049).

  17. On synchronized regions of discrete-time complex dynamical networks

    International Nuclear Information System (INIS)

    Duan Zhisheng; Chen Guanrong

    2011-01-01

    In this paper, the local synchronization of discrete-time complex networks is studied. First, it is shown that for any natural number n, there exists a discrete-time network which has at least left floor n/2 right floor +1 disconnected synchronized regions for local synchronization, which implies the possibility of intermittent synchronization behaviors. Different from the continuous-time networks, the existence of an unbounded synchronized region is impossible for discrete-time networks. The convexity of the synchronized regions is also characterized based on the stability of a class of matrix pencils, which is useful for enlarging the stability region so as to improve the network synchronizability.

  18. Improving plot- and regional-scale crop models for simulating impacts of climate variability and extremes

    Science.gov (United States)

    Tao, F.; Rötter, R.

    2013-12-01

    Many studies on global climate report that climate variability is increasing with more frequent and intense extreme events1. There are quite large uncertainties from both the plot- and regional-scale models in simulating impacts of climate variability and extremes on crop development, growth and productivity2,3. One key to reducing the uncertainties is better exploitation of experimental data to eliminate crop model deficiencies and develop better algorithms that more adequately capture the impacts of extreme events, such as high temperature and drought, on crop performance4,5. In the present study, in a first step, the inter-annual variability in wheat yield and climate from 1971 to 2012 in Finland was investigated. Using statistical approaches the impacts of climate variability and extremes on wheat growth and productivity were quantified. In a second step, a plot-scale model, WOFOST6, and a regional-scale crop model, MCWLA7, were calibrated and validated, and applied to simulate wheat growth and yield variability from 1971-2012. Next, the estimated impacts of high temperature stress, cold damage, and drought stress on crop growth and productivity based on the statistical approaches, and on crop simulation models WOFOST and MCWLA were compared. Then, the impact mechanisms of climate extremes on crop growth and productivity in the WOFOST model and MCWLA model were identified, and subsequently, the various algorithm and impact functions were fitted against the long-term crop trial data. Finally, the impact mechanisms, algorithms and functions in WOFOST model and MCWLA model were improved to better simulate the impacts of climate variability and extremes, particularly high temperature stress, cold damage and drought stress for location-specific and large area climate impact assessments. Our studies provide a good example of how to improve, in parallel, the plot- and regional-scale models for simulating impacts of climate variability and extremes, as needed for

  19. Vacuum assisted closure therapy for treatment of complex wounds in replanted extremities.

    Science.gov (United States)

    Zhou, Min; Qi, Baiwen; Yu, Aixi; Pan, Zhenyu; Zhu, Shaobo; Deng, Kai; Tao, Shengxiang

    2013-11-01

    The object of this study was to compare the outcomes of the vacuum assisted closure (VAC) therapy and conventional wound care with dressing change for treatment of complex wounds in patients with replantation of amputated upper and lower extremities. Data of 43 patients with replantation of amputated extremities from May 2004 to December 2011 were reviewed. There were 18 wounds of 18 patients with replantation, which were treated by dressing change and 26 wounds of 25 patients by VAC therapy. The outcomes were evaluated by the survival rate of replanted extremities, growth of granulation tissue, interval between wound treatment and secondary procedure and eventual secondary wound coverage methods. Vascular thromboses were found in 3 patients with wound treatment by dressing change and 5 by VAC. All replants of two groups of patients survived after salvage procedures. The wound score was 3.6 ± 0.7 in the conventional dressing change group and 5.8 ± 0.7 in the VAC group at the sixth day after treatment, respectively. The intervals between wound treatment and secondary wound coverage procedure were 12.0 ± 1.7 days in the dressing change group and 6.1 ± 0.7 days in the VAC group. Flaps were applied for wound coverage in 9 out of 18 (50.0%) wounds in the dressing change group and 5 out of 26 (19.2%) in the VAC group (P VAC could promote the growth of granulation tissue of wound, decrease the need of flap for wound coverage, and did not change the survival of replantation. Copyright © 2013 Wiley Periodicals, Inc.

  20. Variable complexity online sequential extreme learning machine, with applications to streamflow prediction

    Science.gov (United States)

    Lima, Aranildo R.; Hsieh, William W.; Cannon, Alex J.

    2017-12-01

    In situations where new data arrive continually, online learning algorithms are computationally much less costly than batch learning ones in maintaining the model up-to-date. The extreme learning machine (ELM), a single hidden layer artificial neural network with random weights in the hidden layer, is solved by linear least squares, and has an online learning version, the online sequential ELM (OSELM). As more data become available during online learning, information on the longer time scale becomes available, so ideally the model complexity should be allowed to change, but the number of hidden nodes (HN) remains fixed in OSELM. A variable complexity VC-OSELM algorithm is proposed to dynamically add or remove HN in the OSELM, allowing the model complexity to vary automatically as online learning proceeds. The performance of VC-OSELM was compared with OSELM in daily streamflow predictions at two hydrological stations in British Columbia, Canada, with VC-OSELM significantly outperforming OSELM in mean absolute error, root mean squared error and Nash-Sutcliffe efficiency at both stations.

  1. Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks

    Science.gov (United States)

    Vogel, Martha Marie; Orth, René; Cheruy, Frederique; Hagemann, Stefan; Lorenz, Ruth; van den Hurk, Bart; Seneviratne, Sonia Isabelle

    2017-04-01

    Regional hot extremes are projected to increase more strongly than global mean temperature, with substantially larger changes than 2°C even if global warming is limited to this level. We investigate here the role of soil moisture-temperature feedbacks for this response based on multi-model experiments for the 21st century with either interactive or fixed (late 20th century mean seasonal cycle) soil moisture. We analyze changes in the hottest days in each year in both sets of experiments, relate them to the global mean temperature increase, and investigate physical processes leading to these changes. We find that soil moisture-temperature feedbacks significantly contribute to the amplified warming of hottest days compared to that of global mean temperature. This contribution reaches more than 70% in Central Europe and Central North America and between 42%-52% in Amazonia, Northern Australia and Southern Africa. Soil moisture trends (multi-decadal soil moisture variability) are more important for this response than short-term (e.g. seasonal, interannual) soil moisture variability. These results are relevant for reducing uncertainties in regional temperature projections. Vogel, M.M. et al.,2017. Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks. Geophysical Research Letters, accepted.

  2. Regional frequency analysis of extreme rainfalls using partial L moments method

    Science.gov (United States)

    Zakaria, Zahrahtul Amani; Shabri, Ani

    2013-07-01

    An approach based on regional frequency analysis using L moments and LH moments are revisited in this study. Subsequently, an alternative regional frequency analysis using the partial L moments (PL moments) method is employed, and a new relationship for homogeneity analysis is developed. The results were then compared with those obtained using the method of L moments and LH moments of order two. The Selangor catchment, consisting of 37 sites and located on the west coast of Peninsular Malaysia, is chosen as a case study. PL moments for the generalized extreme value (GEV), generalized logistic (GLO), and generalized Pareto distributions were derived and used to develop the regional frequency analysis procedure. PL moment ratio diagram and Z test were employed in determining the best-fit distribution. Comparison between the three approaches showed that GLO and GEV distributions were identified as the suitable distributions for representing the statistical properties of extreme rainfall in Selangor. Monte Carlo simulation used for performance evaluation shows that the method of PL moments would outperform L and LH moments methods for estimation of large return period events.

  3. Attributing regional effects of the 2014 Jordanian extreme drought to external climate drivers

    Science.gov (United States)

    Bergaoui, Karim; Mitchell, Dann; Zaaboul, Rashyd; Otto, Friederike; McDonnell, Rachael; Dadson, Simon; Allen, Myles

    2015-04-01

    Throughout 2014, the regions of Jordan, Israel, Lebanon and Syria have experienced a persistent draught with clear impacts on the local populations. In this study we perform an extreme event attribution analysis of how such a draught has changed under climate change, with a specific focus on the flow rate of the Upper Jordan river and the water level of Lake Tiberious (AKA the Sea of Galilee). Both of which hold major societal, political and religious importance. To perform the analysis we make use of distributed computing power to run thousands of modelled years of 2014 with slightly different initial conditions. We use an atmosphere only model (HadAM3p) with a nested 50 km regional model covering Africa and the Middle East. The 50 km model atmospheric variables will be used directly to force offline our 1 km LIS surface model. Two separate experiments and simulations are performed, 1. for all known climate forcings that are present in 2014, and 2. for a naturalised 2014 scenario where we assume humans never impacted the climate. We perform sensitivity analyses on the observed precipitation over the regions of interest, and determine that the TRMM data is in good agreement with station data obtained from the Jordanian Ministry of Water. Using a combination of the TRMM and model data we are able to make clear statements on the attribution of a 2014-like extreme draught event to human causal factors.

  4. Impacts of Anthropogenic Aerosols on Regional Climate: Extreme Events, Stagnation, and the United States Warming Hole

    Science.gov (United States)

    Mascioli, Nora R.

    Extreme temperatures, heat waves, heavy rainfall events, drought, and extreme air pollution events have adverse effects on human health, infrastructure, agriculture and economies. The frequency, magnitude and duration of these events are expected to change in the future in response to increasing greenhouse gases and decreasing aerosols, but future climate projections are uncertain. A significant portion of this uncertainty arises from uncertainty in the effects of aerosol forcing: to what extent were the effects from greenhouse gases masked by aerosol forcing over the historical observational period, and how much will decreases in aerosol forcing influence regional and global climate over the remainder of the 21st century? The observed frequency and intensity of extreme heat and precipitation events have increased in the U.S. over the latter half of the 20th century. Using aerosol only (AER) and greenhouse gas only (GHG) simulations from 1860 to 2005 in the GFDL CM3 chemistry-climate model, I parse apart the competing influences of aerosols and greenhouse gases on these extreme events. I find that small changes in extremes in the "all forcing" simulations reflect cancellations between the effects of increasing anthropogenic aerosols and greenhouse gases. In AER, extreme high temperatures and the number of days with temperatures above the 90th percentile decline over most of the U.S., while in GHG high temperature extremes increase over most of the U.S. The spatial response patterns in AER and GHG are significantly anti-correlated, suggesting a preferred regional mode of response that is largely independent of the type of forcing. Extreme precipitation over the eastern U.S. decreases in AER, particularly in winter, and increases over the eastern and central U.S. in GHG, particularly in spring. Over the 21 st century under the RCP8.5 emissions scenario, the patterns of extreme temperature and precipitation change associated with greenhouse gas forcing dominate. The

  5. Characteristics of sub-daily precipitation extremes in observed data and regional climate model simulations

    Science.gov (United States)

    Beranová, Romana; Kyselý, Jan; Hanel, Martin

    2018-04-01

    The study compares characteristics of observed sub-daily precipitation extremes in the Czech Republic with those simulated by Hadley Centre Regional Model version 3 (HadRM3) and Rossby Centre Regional Atmospheric Model version 4 (RCA4) regional climate models (RCMs) driven by reanalyses and examines diurnal cycles of hourly precipitation and their dependence on intensity and surface temperature. The observed warm-season (May-September) maxima of short-duration (1, 2 and 3 h) amounts show one diurnal peak in the afternoon, which is simulated reasonably well by RCA4, although the peak occurs too early in the model. HadRM3 provides an unrealistic diurnal cycle with a nighttime peak and an afternoon minimum coinciding with the observed maximum for all three ensemble members, which suggests that convection is not captured realistically. Distorted relationships of the diurnal cycles of hourly precipitation to daily maximum temperature in HadRM3 further evidence that underlying physical mechanisms are misrepresented in this RCM. Goodness-of-fit tests indicate that generalised extreme value distribution is an applicable model for both observed and RCM-simulated precipitation maxima. However, the RCMs are not able to capture the range of the shape parameter estimates of distributions of short-duration precipitation maxima realistically, leading to either too many (nearly all for HadRM3) or too few (RCA4) grid boxes in which the shape parameter corresponds to a heavy tail. This means that the distributions of maxima of sub-daily amounts are distorted in the RCM-simulated data and do not match reality well. Therefore, projected changes of sub-daily precipitation extremes in climate change scenarios based on RCMs not resolving convection need to be interpreted with caution.

  6. Climate network analysis of regional precipitation extremes: The true story told by event synchronization

    Science.gov (United States)

    Odenweller, Adrian; Donner, Reik V.

    2017-04-01

    Over the last decade, complex network methods have been frequently used for characterizing spatio-temporal patterns of climate variability from a complex systems perspective, yielding new insights into time-dependent teleconnectivity patterns and couplings between different components of the Earth climate. Among the foremost results reported, network analyses of the synchronicity of extreme events as captured by the so-called event synchronization have been proposed to be powerful tools for disentangling the spatio-temporal organization of particularly extreme rainfall events and anticipating the timing of monsoon onsets or extreme floodings. Rooted in the analysis of spike train synchrony analysis in the neurosciences, event synchronization has the great advantage of automatically classifying pairs of events arising at two distinct spatial locations as temporally close (and, thus, possibly statistically - or even dynamically - interrelated) or not without the necessity of selecting an additional parameter in terms of a maximally tolerable delay between these events. This consideration is conceptually justified in case of the original application to spike trains in electroencephalogram (EEG) recordings, where the inter-spike intervals show relatively narrow distributions at high temporal sampling rates. However, in case of climate studies, precipitation extremes defined by daily precipitation sums exceeding a certain empirical percentile of their local distribution exhibit a distinctively different type of distribution of waiting times between subsequent events. This raises conceptual concerns if event synchronization is still appropriate for detecting interlinkages between spatially distributed precipitation extremes. In order to study this problem in more detail, we employ event synchronization together with an alternative similarity measure for event sequences, event coincidence rates, which requires a manual setting of the tolerable maximum delay between two

  7. Conformational changes in the bilirubin-human serum albumin complex at extreme alkaline pH

    DEFF Research Database (Denmark)

    Honoré, B; Frandsen, P C

    1986-01-01

    Light-absorption, c.d. and fluorescence of the bilirubin-albumin complex were investigated at extreme alkaline pH. Above pH 11.1 albumin binds the bilirubin molecule, twisted oppositely to the configuration at more neutral pH. On the basis of light-absorption it is shown that two alkaline...... transitions occur. The first alkaline transition takes place at pH between 11.3 and 11.8, co-operatively dissociating at least six protons. The second alkaline transition takes place at pH between 11.8 and 12.0. It probably implies a reversible unfolding of the albumin molecule, increasing the distance...

  8. Mirror box therapy added to cognitive behavioural therapy in three chronic complex regional pain syndrome type I patients : a pilot study

    NARCIS (Netherlands)

    Tichelaar, Y. I. G. Vladimir; Geertzen, Jan H. B.; Keizer, Doeke; van Wilgen, C. Paul

    Complex regional pain syndrome type I is a disorder of the extremities with disability and pain as the most prominent features. This paper describes the results of cognitive behavioural therapy combined with mirror box therapy in three patients with chronic complex regional pain syndrome type I.

  9. COMPLEX REGIONAL PAIN SYNDROME – CLINIC, DIAGNOSTICS, TREATMENT

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2014-07-01

    Full Text Available The problem of pain today remains one of the fundamental issues of medical care. It is known that the pain is the leading cause of treatmentto the doctor. Among pain syndromes, a special place belongs to the complex regional pain syndromes. They are distinguished by the multidisciplinary problem, the presence of explicit nature of the pain, difficulty of diagnosis and nature of the treatment. The article presentsmodern data on the diagnosis and treatment of the complex regional pain syndromes.

  10. COMPLEX REGIONAL PAIN SYNDROME – CLINIC, DIAGNOSTICS, TREATMENT

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2013-01-01

    Full Text Available The problem of pain today remains one of the fundamental issues of medical care. It is known that the pain is the leading cause of treatmentto the doctor. Among pain syndromes, a special place belongs to the complex regional pain syndromes. They are distinguished by the multidisciplinary problem, the presence of explicit nature of the pain, difficulty of diagnosis and nature of the treatment. The article presentsmodern data on the diagnosis and treatment of the complex regional pain syndromes.

  11. The impact of anthropogenic land use and land cover change on regional climate extremes.

    Science.gov (United States)

    Findell, Kirsten L; Berg, Alexis; Gentine, Pierre; Krasting, John P; Lintner, Benjamin R; Malyshev, Sergey; Santanello, Joseph A; Shevliakova, Elena

    2017-10-20

    Land surface processes modulate the severity of heat waves, droughts, and other extreme events. However, models show contrasting effects of land surface changes on extreme temperatures. Here, we use an earth system model from the Geophysical Fluid Dynamics Laboratory to investigate regional impacts of land use and land cover change on combined extremes of temperature and humidity, namely aridity and moist enthalpy, quantities central to human physiological experience of near-surface climate. The model's near-surface temperature response to deforestation is consistent with recent observations, and conversion of mid-latitude natural forests to cropland and pastures is accompanied by an increase in the occurrence of hot-dry summers from once-in-a-decade to every 2-3 years. In the tropics, long time-scale oceanic variability precludes determination of how much of a small, but significant, increase in moist enthalpy throughout the year stems from the model's novel representation of historical patterns of wood harvesting, shifting cultivation, and regrowth of secondary vegetation and how much is forced by internal variability within the tropical oceans.

  12. Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks

    Science.gov (United States)

    Vogel, M. M.; Orth, R.; Cheruy, F.; Hagemann, S.; Lorenz, R.; Hurk, B. J. J. M.; Seneviratne, S. I.

    2017-02-01

    Regional hot extremes are projected to increase more strongly than global mean temperature, with substantially larger changes than 2°C even if global warming is limited to this level. We investigate the role of soil moisture-temperature feedbacks for this response based on multimodel experiments for the 21st century with either interactive or fixed (late 20th century mean seasonal cycle) soil moisture. We analyze changes in the hottest days in each year in both sets of experiments, relate them to the global mean temperature increase, and investigate processes leading to these changes. We find that soil moisture-temperature feedbacks significantly contribute to the amplified warming of the hottest days compared to that of global mean temperature. This contribution reaches more than 70% in Central Europe and Central North America. Soil moisture trends are more important for this response than short-term soil moisture variability. These results are relevant for reducing uncertainties in regional temperature projections.

  13. Comparison of regional index flood estimation procedures based on the extreme value type I distribution

    DEFF Research Database (Denmark)

    Kjeldsen, Thomas Rodding; Rosbjerg, Dan

    2002-01-01

    the prediction uncertainty and that the presence of intersite correlation tends to increase the uncertainty. A simulation study revealed that in regional index-flood estimation the method of probability weighted moments is preferable to method of moment estimation with regard to bias and RMSE.......A comparison of different methods for estimating T-year events is presented, all based on the Extreme Value Type I distribution. Series of annual maximum flood from ten gauging stations at the New Zealand South island have been used. Different methods of predicting the 100-year event...... and the connected uncertainty have been applied: At-site estimation and regional index-flood estimation with and without accounting for intersite correlation using either the method of moments or the method of probability weighted moments for parameter estimation. Furthermore, estimation at ungauged sites were...

  14. Complex Regional Pain Syndrome in Children: Asking the Right Questions

    Directory of Open Access Journals (Sweden)

    Kenneth R Goldschneider

    2012-01-01

    Full Text Available BACKGROUND: Complex regional pain syndrome (CRPS is a painful disorder without a known unifying mechanism. There are little data on which to base evaluation and treatment decisions, and what data are available come from studies involving adults; however, even that literature is relatively sparse. Developing robust research for CRPS in children is essential for the progress toward optimal treatment.

  15. Neuroimmune Alterations in the Complex Regional Pain Syndrome

    NARCIS (Netherlands)

    F.J.P.M. Huygen (Frank)

    2004-01-01

    textabstractComplex Regional Pain Syndrome (CRPS) is a disease which occurs as a complication after surgery or trauma, although spontaneous development is described. CRPS is characterized by continuing pain, sensory and vasomotor, sudomotor, motor and trophic disturbances. Many of these symptoms are

  16. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1

    African Journals Online (AJOL)

    Enrique

    with MRI every 3 months and the bone marrow oedema disappeared after 6 months. Introduction ... SA JOURNAL OF RADIOLOGY • August 2004. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1 ... may be either trauma of external origin or iatrogenic, post surgery. In some patients particularly children ...

  17. [Complex regional pain syndrome type 1: negating the myth

    NARCIS (Netherlands)

    Frolke, J.P.M.; Dongen, R.T.M. van; Meent, H. van de

    2015-01-01

    Complex regional pain syndrome type 1 (CRPS-1) was identified in the Netherlands more than 30 years ago, but since then the arguments supporting this diagnosis have become weaker. Incidence has decreased, it is often not possible to make a definite diagnosis, the pathophysiology remains unclear and

  18. Evidence based guidelines for complex regional pain syndrome type 1

    NARCIS (Netherlands)

    Perez, R.S.G.M.; Zollinger, P.E.; Dijkstra, P.U.; Thomassen-Hilgersom, I.L.; Zuurmond, W.W.A.; Rosenbrand, C.J.G.M.; Geerzen, J.H.B.

    2010-01-01

    Background: Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I.Method: A multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according

  19. Evidence based guidelines for complex regional pain syndrome type 1

    NARCIS (Netherlands)

    Perez, Roberto S.; Zollinger, Paul E.; Dijkstra, Pieter U.; Thomassen-Hilgersom, Ilona L.; Zuurmond, Wouter W.; Rosenbrand, Kitty C. J.; Geertzen, Jan H.

    2010-01-01

    Background: Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I. Method: A multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according

  20. Is there Complex Trauma Experience typology for Australian's experiencing extreme social disadvantage and low housing stability?

    Science.gov (United States)

    Keane, Carol A; Magee, Christopher A; Kelly, Peter J

    2016-11-01

    Traumatic childhood experiences predict many adverse outcomes in adulthood including Complex-PTSD. Understanding complex trauma within socially disadvantaged populations has important implications for policy development and intervention implementation. This paper examined the nature of complex trauma experienced by disadvantaged individuals using a latent class analysis (LCA) approach. Data were collected through the large-scale Journeys Home Study (N=1682), utilising a representative sample of individuals experiencing low housing stability. Data on adverse childhood experiences, adulthood interpersonal trauma and relevant covariates were collected through interviews at baseline (Wave 1). Latent class analysis (LCA) was conducted to identify distinct classes of childhood trauma history, which included physical assault, neglect, and sexual abuse. Multinomial logistic regression investigated childhood relevant factors associated with class membership such as biological relationship of primary carer at age 14 years and number of times in foster care. Of the total sample (N=1682), 99% reported traumatic adverse childhood experiences. The most common included witnessing of violence, threat/experience of physical abuse, and sexual assault. LCA identified six distinct childhood trauma history classes including high violence and multiple traumas. Significant covariate differences between classes included: gender, biological relationship of primary carer at age 14 years, and time in foster care. Identification of six distinct childhood trauma history profiles suggests there might be unique treatment implications for individuals living in extreme social disadvantage. Further research is required to examine the relationship between these classes of experience, consequent impact on adulthood engagement, and future transitions though homelessness. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Risk Factors for Post-treatment Complex Regional Pain Syndrome (CRPS)

    DEFF Research Database (Denmark)

    Petersen, Pelle B; Mikkelsen, Kim Lyngby; Lauritzen, Jes B

    2018-01-01

    OBJECTIVES: Complex regional pain syndrome is a challenging condition that includes a broad spectrum of sensory, autonomic, and motor features predominantly in extremities recovering from a trauma. Few large-scale studies have addressed occurrence of and factors associated with complex regional......, gender, initial diagnosis, treatment, and amount of compensation were extracted. Multivariate logistic regressions were performed to identify variables associated with approval of the claim. For carpal tunnel syndrome (CTS) patients, we registered whether symptoms were bilateral or unilateral...... normal neurophysiology. CONCLUSIONS: Female gender, surgical treatment, and treatment to the upper limb were risk factors. Elective surgery accounted for a large number of post-treatment CRPS patients. In CTS patients developing CRPS, normal neurophysiological examination findings were common...

  2. Simulation of climate characteristics and extremes of the Volta Basin using CCLM and RCA regional climate models

    Science.gov (United States)

    Darko, Deborah; Adjei, Kwaku A.; Appiah-Adjei, Emmanuel K.; Odai, Samuel N.; Obuobie, Emmanuel; Asmah, Ruby

    2018-06-01

    The extent to which statistical bias-adjusted outputs of two regional climate models alter the projected change signals for the mean (and extreme) rainfall and temperature over the Volta Basin is evaluated. The outputs from two regional climate models in the Coordinated Regional Climate Downscaling Experiment for Africa (CORDEX-Africa) are bias adjusted using the quantile mapping technique. Annual maxima rainfall and temperature with their 10- and 20-year return values for the present (1981-2010) and future (2051-2080) climates are estimated using extreme value analyses. Moderate extremes are evaluated using extreme indices (viz. percentile-based, duration-based, and intensity-based). Bias adjustment of the original (bias-unadjusted) models improves the reproduction of mean rainfall and temperature for the present climate. However, the bias-adjusted models poorly reproduce the 10- and 20-year return values for rainfall and maximum temperature whereas the extreme indices are reproduced satisfactorily for the present climate. Consequently, projected changes in rainfall and temperature extremes were weak. The bias adjustment results in the reduction of the change signals for the mean rainfall while the mean temperature signals are rather magnified. The projected changes for the original mean climate and extremes are not conserved after bias adjustment with the exception of duration-based extreme indices.

  3. Challenges of Tsunami Disaster and Extreme climate Events Along Coastal Region in Asia-Pacific

    Science.gov (United States)

    Chaudhari, S.

    2017-12-01

    South Asia is more vulnerable to Geo disasters and impacts of climate changes in recent years. On 26 December 2004 massive waves triggered by an earthquake surged into coastal communities in Asia and East Africa with devastating force. Hitting Indonesia, Sri Lanka , Thailand and India hardest, the deadly waves swept more than 200 000 people to their deaths. Also in an another extreme climate change phenomenon during 2005 - 2006,causing heavy rains and flooding situation in the South Asia - Europe and Pacific region ,more than 100 million population in these regions are witnessing the social- economical and ecological risks and impacts due to climate changes and Geohazards. For mitigating geo-disasters, marine hazards and rehabilitation during post tsunami period, scientific knowledge is needed, requiring experienced research communities who can train the local population during tsunami rehabilitation. Several civil society institutions jointly started the initiatives on the problem identifications in management of risks in geo-disasters, tsunami rehabilitation ,Vulnerability and risk assessments for Geohazards etc., to investigate problems related to social-economic and ecological risks and management issues resulting from the December tsunami and Geo- disaster, to aid mitigation planning in affected areas and to educate scientists and local populations to form a basis for sustainable and economic solutions. The poster aims to assess the potential risk and hazard , technical issues, problems and damage arising from Tsunami in the Asia-pacific region in coastal geology, coastal ecosystems and coastal environmental systems . This poster deals with the status and issues of interactions between Human and Ocean Systems, Geo-risks, marine risks along coastal region of Asia- Pacific and also human influence on the earth system . The poster presentation focuses on capacity building of the local population, scientists and researchers for integration of human and ocean

  4. Contribution of Large Region Joint Associations to Complex Traits Genetics

    Science.gov (United States)

    Paré, Guillaume; Asma, Senay; Deng, Wei Q.

    2015-01-01

    A polygenic model of inheritance, whereby hundreds or thousands of weakly associated variants contribute to a trait’s heritability, has been proposed to underlie the genetic architecture of complex traits. However, relatively few genetic variants have been positively identified so far and they collectively explain only a small fraction of the predicted heritability. We hypothesized that joint association of multiple weakly associated variants over large chromosomal regions contributes to complex traits variance. Confirmation of such regional associations can help identify new loci and lead to a better understanding of known ones. To test this hypothesis, we first characterized the ability of commonly used genetic association models to identify large region joint associations. Through theoretical derivation and simulation, we showed that multivariate linear models where multiple SNPs are included as independent predictors have the most favorable association profile. Based on these results, we tested for large region association with height in 3,740 European participants from the Health and Retirement Study (HRS) study. Adjusting for SNPs with known association with height, we demonstrated clustering of weak associations (p = 2x10-4) in regions extending up to 433.0 Kb from known height loci. The contribution of regional associations to phenotypic variance was estimated at 0.172 (95% CI 0.063-0.279; p < 0.001), which compared favorably to 0.129 explained by known height variants. Conversely, we showed that suggestively associated regions are enriched for known height loci. To extend our findings to other traits, we also tested BMI, HDLc and CRP for large region associations, with consistent results for CRP. Our results demonstrate the presence of large region joint associations and suggest these can be used to pinpoint weakly associated SNPs. PMID:25856144

  5. Complex Regional Pain Syndrome (CRPS/RSD and Neuropathic Pain: Role of Intravenous Bisphosphonates as Analgesics

    Directory of Open Access Journals (Sweden)

    Jennifer Yanow

    2008-01-01

    Full Text Available Neuropathic pain is a sequela of dysfunction, injuries, or diseases of the peripheral and/or central nervous system pain pathways, which has historically been extremely difficult to treat. Complex regional pain syndrome (CRPS types 1 and 2 are neuropathic pain conditions that have a long history in the medical literature but whose pathophysiology remains elusive and whose available treatment options remain few. While an exact animal model for CRPS doesn't yet exist, there are several animal models of neuropathic pain that develop behaviors of hypersensitivity, one of the hallmark signs of neuropathic pain in humans.

  6. Post-traumatic complex regional pain syndrome: clinical features and epidemiology

    Science.gov (United States)

    Ratti, Chiara; Nordio, Andrea; Resmini, Giuseppina; Murena, Luigi

    2015-01-01

    Summary Complex Regional Pain Syndrome (CRPS) is a chronic pain condition that occurs after a tissue injury (fractures, sprain, surgery) of the upper or lower extremities. A clear pathophysiological mechanism has not been established yet and different patterns are considered to play a role in the genesis of the disease. The diagnosis is made by different diagnosis criteria and a gold standard has not been established yet. Incidence of CRPS is unclear and large prospective studies on the incidence and prevalence of CRPS are scarce. The aim of this review is to give an overview on the prevalent data regarding this chronic syndrome. PMID:27134626

  7. Bilateral Complex Regional Pain Syndrome after Fracture of Bilateral Tibia and Fibula

    Directory of Open Access Journals (Sweden)

    Senem Şaş

    2017-04-01

    Full Text Available Complex regional syndrome type 1 (CRPS-1 is a painful clinical condition. It occurs after a painful event and characterized by allodynia, hyperalgesia, edema, abnormalities in skin blood flow and abnormal sudomotor activity. When CRPS-1 is associated with nerve injury, it is defined as CRPS-2. Central and peripheral theory are responsible in etiopathogenesis of CRPS-1. Generally it occurs in the injured limb. But, it may ocur in the opposite extremities. In this article, we present a case developing bilateral CRPS-1 after bilateral tibia and fibula fracture by reviewing current literatüre.

  8. Extreme nitrogen deposition can change methane oxidation rate in moist acidic tundra soil in Arctic regions

    Science.gov (United States)

    Lee, J.; Kim, J.; Kang, H.

    2017-12-01

    Recently, extreme nitrogen(N) deposition events are observed in Arctic regions where over 90% of the annual N deposition occurred in just a few days. Since Arctic ecosystems are typically N-limited, input of extremely high amount of N could substantially affect ecosystem processes. CH4 is a potent greenhouse gas that has 25 times greater global warming potential than CO2 over a 100-year time frame. Ammonium is known as an inhibitor of methane oxidation and nitrate also shows inhibitory effect on it in temperate ecosystems. However, effects of N addition on Arctic ecosystems are still elusive. We conducted a lab-scale incubation experiment with moist acidic tundra (MAT) soil from Council, Alaska to investigate the effect of extreme N deposition events on methane oxidation. Zero point five % methane was added to the head space to determine the potential methane oxidation rate of MAT soil. Three treatments (NH4NO3-AN, (NH4)2SO4-AS, KNO3-PN) were used to compare effects of ammonium, nitrate and salts. All treatments were added in 3 levels: 10μg N gd.w-1(10), 50μg N gd.w-1(50) and 100μg N gd.w-1(100). AN10 and AN50 increased methane oxidation rate 1.7, 6% respectively. However, AN100 shows -8.5% of inhibitory effect. In AS added samples, all 3 concentrations (AN10, AN50, AN100) stimulated methane oxidation rate with 4.7, 8.9, 4%, respectively. On the contrary, PN50 (-9%) and PN100 (-59.5%) exhibited a significant inhibitory effect. We also analyzed the microbial gene abundance and community structures of methane oxidizing bacteria using a DNA-based fingerprinting method (T-RFLP) Our study results suggest that NH4+ can stimulate methane oxidation in Arctic MAT soil, while NO3- can inhibit methane oxidation significantly.

  9. Possible association between serotonin transporter promoter region polymorphism and extremely violent crime in Chinese males.

    Science.gov (United States)

    Liao, Ding-Lieh; Hong, Chen-Jee; Shih, Hao-Ling; Tsai, Shih-Jen

    2004-01-01

    The neurotransmitter, serotonin, has been implicated in aggressive behavior. The serotonin transporter (5-HTT), which reuptakes serotonin into the nerve terminal, plays a critical role in the regulation of serotonergic function. Previous western reports have demonstrated that the low-activity short (S) allele of the 5-HTT gene-linked polymorphic-region (5-HTTLPR) polymorphism is associated with aggressive behavior and associated personality traits. In the present study, we investigated this 5-HTTLPR genetic polymorphism in a group of Chinese males who had been convicted for extremely violent crime (n = 135) and a normal control group (n = 111). The proportion of S-allele carriers was significantly higher in the criminal group than in the controls (p = 0.006). A significant association was not demonstrated for the relationship between the 5-HTTLPR polymorphism and antisocial personality disorder, substance abuse or alcohol abuse in the criminal group. Our findings demonstrate that carriage of the low-activity S allele is associated with extremely violent criminal behavior in Chinese males, and suggests that the 5-HTT may be implicated in the mechanisms underlying violent behaviors.

  10. Distant and Regional Atmospheric Circulation Influences Governing Integrated Water Vapor Transport and the Occurrence of Extreme Precipitation Events

    Science.gov (United States)

    Bosart, L. F.; Papin, P. P.; Bentley, A. M.

    2017-12-01

    This presentation will show how the evolution of the large-scale and regional-scale atmospheric circulation contributes to the occurrence of extreme precipitation events (EPEs). An EPE requires that tropospheric moisture flux convergence (MFC) and the associated removal of hydrometeors be balanced by moisture replenishment via integrated (water) vapor transport (IVT) to continuously replenish condensed moisture. Moisture source regions may be distant or regional. Distant moisture sources may require the interaction of lower- and upper-level jet streams with a pre-existing mobile atmospheric disturbance to produce sufficient lift to condense moisture. Pre-existing regional moisture sources may require frontal lifting the presence of MFC to condense moisture. In cases of long-range IVT, such as moisture from a western North Pacific typhoon being drawn poleward along an atmospheric river (AR) toward the west coast of North America, moisture may be transported 1000s of kilometers along a low-level jet before a combination of dynamic and orographic lift results in an EPE. Alternatively, in the case of a typical summer warm and humid air mass over the continental United States, unused moisture may exist for several days in this air mass before sufficient MFC associated with a thermally direct mesoscale frontal circulation can concentrate and condense the moisture. In this case, there may be no long-range IVT via ARs. Instead, the atmospheric circulations may evolve to produce sustained MFC associated with mesoscale frontal circulations, especially in the presence of complex terrain, to produce an EPE. During this presentation, examples of EPEs associated with long-range IVT and distant MFC versus EPEs associated with regional MFC and mesoscale frontal circulations will be illustrated.

  11. Extreme-Scale Bayesian Inference for Uncertainty Quantification of Complex Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Biros, George [Univ. of Texas, Austin, TX (United States)

    2018-01-12

    Uncertainty quantification (UQ)—that is, quantifying uncertainties in complex mathematical models and their large-scale computational implementations—is widely viewed as one of the outstanding challenges facing the field of CS&E over the coming decade. The EUREKA project set to address the most difficult class of UQ problems: those for which both the underlying PDE model as well as the uncertain parameters are of extreme scale. In the project we worked on these extreme-scale challenges in the following four areas: 1. Scalable parallel algorithms for sampling and characterizing the posterior distribution that exploit the structure of the underlying PDEs and parameter-to-observable map. These include structure-exploiting versions of the randomized maximum likelihood method, which aims to overcome the intractability of employing conventional MCMC methods for solving extreme-scale Bayesian inversion problems by appealing to and adapting ideas from large-scale PDE-constrained optimization, which have been very successful at exploring high-dimensional spaces. 2. Scalable parallel algorithms for construction of prior and likelihood functions based on learning methods and non-parametric density estimation. Constructing problem-specific priors remains a critical challenge in Bayesian inference, and more so in high dimensions. Another challenge is construction of likelihood functions that capture unmodeled couplings between observations and parameters. We will create parallel algorithms for non-parametric density estimation using high dimensional N-body methods and combine them with supervised learning techniques for the construction of priors and likelihood functions. 3. Bayesian inadequacy models, which augment physics models with stochastic models that represent their imperfections. The success of the Bayesian inference framework depends on the ability to represent the uncertainty due to imperfections of the mathematical model of the phenomena of interest. This is a

  12. Sensitivity Analysis of Expected Wind Extremes over the Northwestern Sahara and High Atlas Region.

    Science.gov (United States)

    Garcia-Bustamante, E.; González-Rouco, F. J.; Navarro, J.

    2017-12-01

    A robust statistical framework in the scientific literature allows for the estimation of probabilities of occurrence of severe wind speeds and wind gusts, but does not prevent however from large uncertainties associated with the particular numerical estimates. An analysis of such uncertainties is thus required. A large portion of this uncertainty arises from the fact that historical observations are inherently shorter that the timescales of interest for the analysis of return periods. Additional uncertainties stem from the different choices of probability distributions and other aspects related to methodological issues or physical processes involved. The present study is focused on historical observations over the Ouarzazate Valley (Morocco) and in a high-resolution regional simulation of the wind in the area of interest. The aim is to provide extreme wind speed and wind gust return values and confidence ranges based on a systematic sampling of the uncertainty space for return periods up to 120 years.

  13. Regional air-sea coupled model simulation for two types of extreme heat in North China

    Science.gov (United States)

    Li, Donghuan; Zou, Liwei; Zhou, Tianjun

    2018-03-01

    Extreme heat (EH) over North China (NC) is affected by both large scale circulations and local topography, and could be categorized into foehn favorable and no-foehn types. In this study, the performance of a regional coupled model in simulating EH over NC was examined. The effects of regional air-sea coupling were also investigated by comparing the results with the corresponding atmosphere-alone regional model. On foehn favorable (no-foehn) EH days, a barotropic cyclonic (anticyclonic) anomaly is located to the northeast (northwest) of NC, while anomalous northwesterlies (southeasterlies) prevail over NC in the lower troposphere. In the uncoupled simulation, barotropic anticyclonic bias occurs over China on both foehn favorable and no-foehn EH days, and the northwesterlies in the lower troposphere on foehn favorable EH days are not obvious. These biases are significantly reduced in the regional coupled simulation, especially on foehn favorable EH days with wind anomalies skill scores improving from 0.38 to 0.47, 0.47 to 0.61 and 0.38 to 0.56 for horizontal winds at 250, 500 and 850 hPa, respectively. Compared with the uncoupled simulation, the reproduction of the longitudinal position of Northwest Pacific subtropical high (NPSH) and the spatial pattern of the low-level monsoon flow over East Asia are improved in the coupled simulation. Therefore, the anticyclonic bias over China is obviously reduced, and the proportion of EH days characterized by anticyclonic anomaly is more appropriate. The improvements in the regional coupled model indicate that it is a promising choice for the future projection of EH over NC.

  14. Atmospheric conditions associated with extreme fire activity in the Western Mediterranean region.

    Science.gov (United States)

    Amraoui, Malik; Pereira, Mário G; DaCamara, Carlos C; Calado, Teresa J

    2015-08-15

    Active fire information provided by TERRA and AQUA instruments on-board sun-synchronous polar MODIS platform is used to describe fire activity in the Western Mediterranean and to identify and characterize the synoptic patterns of several meteorological fields associated with the occurrence of extreme fire activity episodes (EEs). The spatial distribution of the fire pixels during the period of 2003-2012 leads to the identification of two most affected sub-regions, namely the Northern and Western parts of the Iberian Peninsula (NWIP) and Northern Africa (NAFR). The temporal distribution of the fire pixels in these two sub-regions is characterized by: (i) high and non-concurrent inter- and intra-annual variability with maximum values during the summer of 2003 and 2005 in NWIP and 2007 and 2012 in NAFR; and, (ii) high intra-annual variability dominated by a prominent annual cycle with a main peak centred in August in both sub-regions and a less pronounced secondary peak in March only evident in NWIP region. The 34 EEs identified were grouped according to the location, period of occurrence and spatial configuration of the associated synoptic patterns into 3 clusters (NWIP-summer, NWIP-winter and NAFR-summer). Results from the composite analysis reveal similar fire weather conditions (statistically significant positive anomalies of air temperature and negative anomalies of air relative humidity) but associated with different circulation patterns at lower and mid-levels of the atmosphere associated with the occurrence of EEs in each cluster of the Western Mediterranean region. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Regional metamorphism at extreme conditions: Implications for orogeny at convergent plate margins

    Science.gov (United States)

    Zheng, Yong-Fei; Chen, Ren-Xu

    2017-09-01

    Regional metamorphism at extreme conditions refers either to Alpine-type metamorphism at low geothermal gradients of geothermal gradients of >30 °C/km. Extreme pressures refer to those above the polymorphic transition of quartz to coesite, so that ultrahigh-pressure (UHP) eclogite-facies metamorphism occurs at mantle depths of >80 km. Extreme temperatures refer to those higher than 900 °C at crustal depths of ≤80 km, so that ultrahigh-temperature (UHT) granulite-facies metamorphism occurs at medium to high pressures. While crustal subduction at the low geothermal gradients results in blueschist-eclogite facies series without arc volcanism, heating of the thinned orogenic lithosphere brings about the high geothermal gradients for amphibolite-granulite facies series with abundant magmatism. Therefore, UHP metamorphic rocks result from cold lithospheric subduction to the mantle depths, whereas UHT metamorphic rocks are produced by hot underplating of the asthenospheric mantle at the crustal depths. Active continental rifting is developed on the thinned lithosphere in response to asthenospheric upwelling, and this tectonism is suggested as a feasible mechanism for regional granulite-facies metamorphism, with the maximum temperature depending on the extent to which the mantle lithosphere is thinned prior to the rifting. While lithospheric compression is associated with subduction metamorphism in accretionary and collisional orogens, the thinned orogenic lithosphere undergoes extension due to the asthenospheric upwelling to result in orogen-parallel rifting metamorphism and magmatism. Thus, the rifting metamorphism provides a complement to the subduction metamorphism and its operation marks the asthenospheric heating of the orogenic lithosphere. Because of the partial melting and melt extraction of the lower continental crust, contemporaneous granite-migmatite-granulite associations may serve as a petrological indicator of rifting orogeny that is superimposed on

  16. Impact of climate change on hydrological extremes in Dobrogea region, Romania

    Science.gov (United States)

    Buta, Constantin; Maftei, Carmen

    2015-04-01

    Over time, Dobrogea territory has faced with fluctuations more or less severe in terms of basic parameters such as temperature, precipitations and annual discharges of rivers. It is highlighted the trend of aridity in the area, because of the fact that Dobrogea receives small amounts of water, ranging between 200-450 mm/year, with annual average temperatures lying around and above the average of 11°C. This fact is also proceeding from the many studies realized by other researchers. For this area there are also characteristic torrents (form of rainfall during the summer), the storms and floods accompanying these torrents of water on the narrow valleys, often intermittent, sometimes causing significant damage and even fatalities. Torrential rainfalls and flash floods are sometimes very strong and produce catastrophic damages, as happened at Constanta (in 2001), at Tulcea (in 13.07.2004 and in 29.08.2004), at Tuzla, Pantelimon, Agigea and others. At the opposite pole of the sporadic excess rainfall is drought, which is the largest meteorological phenomenon (both in time and in space) and the most obvious in Dobrogea climate. Drought represents the main argument of semi aridity of this region and the most visible image component which is observed by the inhabitants of this environment. Correlation and study of hydro-meteorological extremes is performed using indices that take into account meteorological and hydrological parameters such as precipitations, temperature, discharges of rivers etc. Hydro-meteorological indices used for this study are: Angot rainfall index; Peguy Climograms; de Martonne drought index; Thornthwaite index Moduli coefficients and Deciles. According to the studied indices, for the accomplishment of this present paper, we can say that Dobrogea is among the driest regions in the country. History of drought in Romania includes many dry years, of which are mentioned: 1894, 1888, 1904, 1918, 1934, 1945, but the droughts years with greater durations

  17. Optimizing velocities and transports for complex coastal regions and archipelagos

    Science.gov (United States)

    Haley, Patrick J.; Agarwal, Arpit; Lermusiaux, Pierre F. J.

    2015-05-01

    We derive and apply a methodology for the initialization of velocity and transport fields in complex multiply-connected regions with multiscale dynamics. The result is initial fields that are consistent with observations, complex geometry and dynamics, and that can simulate the evolution of ocean processes without large spurious initial transients. A class of constrained weighted least squares optimizations is defined to best fit first-guess velocities while satisfying the complex bathymetry, coastline and divergence strong constraints. A weak constraint towards the minimum inter-island transports that are in accord with the first-guess velocities provides important velocity corrections in complex archipelagos. In the optimization weights, the minimum distance and vertical area between pairs of coasts are computed using a Fast Marching Method. Additional information on velocity and transports are included as strong or weak constraints. We apply our methodology around the Hawaiian islands of Kauai/Niihau, in the Taiwan/Kuroshio region and in the Philippines Archipelago. Comparisons with other common initialization strategies, among hindcasts from these initial conditions (ICs), and with independent in situ observations show that our optimization corrects transports, satisfies boundary conditions and redirects currents. Differences between the hindcasts from these different ICs are found to grow for at least 2-3 weeks. When compared to independent in situ observations, simulations from our optimized ICs are shown to have the smallest errors.

  18. Critical Hydrologic and Atmospheric Measurements in Complex Alpine Regions

    Science.gov (United States)

    Parlange, M. B.; Bou-Zeid, E.; Barrenetxea, G.; Krichane, M.; Ingelrest, F.; Couach, O.; Luyet, V.; Vetterli, M.; Lehning, M.; Duffy, C.; Tobin, C.; Selker, J.; Kumar, M.

    2007-12-01

    The Alps are often referred to as the « Water Towers of Europe » and as such play an essential role in European water resources. The impact of climatic change is expected to be particularly pronounced in the Alps and the lack of detailed hydrologic field observations is problematic for predictions of hydrologic and hazard assessment. Advances in information technology and communications provide important possibilities to improve the situation with relatively few measurements. We will present sensorscope technology (arrays of wireless weather stations including soil moisture, pressure, and temperature) that has now been deployed at the Le Genepi and Grand St. Bernard pass. In addition, a Distributed Temperature Sensor array on the stream beds has been deployed and stream discharge monitored. The high spatial resolution data collected in these previously "ungaged" regions are used in conjunction with new generation hydrologic models. The framework as to what is possible today with sensor arrays and modeling in extreme mountain environments is discussed.

  19. Simulated trends of extreme climate indices for the Carpathian basin using outputs of different regional climate models

    Science.gov (United States)

    Pongracz, R.; Bartholy, J.; Szabo, P.; Pieczka, I.; Torma, C. S.

    2009-04-01

    Regional climatological effects of global warming may be recognized not only in shifts of mean temperature and precipitation, but in the frequency or intensity changes of different climate extremes. Several climate extreme indices are analyzed and compared for the Carpathian basin (located in Central/Eastern Europe) following the guidelines suggested by the joint WMO-CCl/CLIVAR Working Group on climate change detection. Our statistical trend analysis includes the evaluation of several extreme temperature and precipitation indices, e.g., the numbers of severe cold days, winter days, frost days, cold days, warm days, summer days, hot days, extremely hot days, cold nights, warm nights, the intra-annual extreme temperature range, the heat wave duration, the growing season length, the number of wet days (using several threshold values defining extremes), the maximum number of consecutive dry days, the highest 1-day precipitation amount, the greatest 5-day rainfall total, the annual fraction due to extreme precipitation events, etc. In order to evaluate the future trends (2071-2100) in the Carpathian basin, daily values of meteorological variables are obtained from the outputs of various regional climate model (RCM) experiments accomplished in the frame of the completed EU-project PRUDENCE (Prediction of Regional scenarios and Uncertainties for Defining EuropeaN Climate change risks and Effects). Horizontal resolution of the applied RCMs is 50 km. Both scenarios A2 and B2 are used to compare past and future trends of the extreme climate indices for the Carpathian basin. Furthermore, fine-resolution climate experiments of two additional RCMs adapted and run at the Department of Meteorology, Eotvos Lorand University are used to extend the trend analysis of climate extremes for the Carpathian basin. (1) Model PRECIS (run at 25 km horizontal resolution) was developed at the UK Met Office, Hadley Centre, and it uses the boundary conditions from the HadCM3 GCM. (2) Model Reg

  20. Impacts of the 2013 Extreme Flood in Northeast China on Regional Groundwater Depth and Quality

    Directory of Open Access Journals (Sweden)

    Xihua Wang

    2015-08-01

    Full Text Available Flooding’s impact on shallow groundwater is not well investigated. In this study, we analyzed changes in the depth and quality of a regional shallow aquifer in the 10.9 × 104 km2 Sanjiang Plain, Northeast China, following a large flood in the summer of 2013. Pre- (2008–2012 and post-flood records on groundwater table depth and groundwater chemistry were gathered from 20 wells across the region. Spatial variability of groundwater recharge after the flood was assessed and the changes in groundwater quality in the post-flood period were determined. The study found a considerable increase in the groundwater table after the 2013 summer flood across the region, with the largest (3.20 m and fastest (0.80 m·s−1 rising height occurring in western Sanjiang Plain. The rising height and velocity gradually declined from the west to the east of the plain. For the entire region, we estimated an average recharge height of 1.24 m for the four flood months (June to September of 2013. Furthermore, we found that the extreme flood reduced nitrate (NO3− and chloride (Cl− concentrations and electrical conductivity (EC in shallow groundwater in the areas that were close to rivers, but increased NO3− and Cl− concentrations and EC in the areas that were under intensive agricultural practices. As the region’s groundwater storage and quality have been declining due to the rapidly increasing rice cultivation, this study shows that floods should be managed as water resources to ease the local water shortage as well as shallow groundwater pollution.

  1. "Complex" Posttraumatic Stress Disorder/Disorders of Extreme Stress (CP/DES) in Sexually Abused Children: An Exloratory Study.

    Science.gov (United States)

    Hall, Darlene Kordich

    1999-01-01

    Compares three groups of young sexually abused children on seven "Complex" Posttraumatic Stress Disorder/Disorders of Extreme Stress (CP/DES) indices. As cumulative number of types of trauma increased, the number of CP/DES symptoms rose. Results suggest that CP/DES also characterizes sexually abused children, especially those who have…

  2. Bacterial Diversity within the Extreme Arid Atacama Desert Soils of the Yungay Region, Chile

    Science.gov (United States)

    Connon, S. A.; Lester, E. D.; Shafaat, H. S.; Obenhuber, D. C.; Ponce, A.

    2006-12-01

    Surface and subsurface soil samples analyzed for this study were collected from the hyper-arid Yungay region of the Atacama Desert, Chile. This is the first report of microbial diversity from DNA extracted directly from these extremely desiccated soils. Our data shows that 94% of the 16S rRNA genes cloned from these soils belong to the Actinobacteria phylum. A 24-hour time course series showed a diurnal water activity (aw) cycle that peaked at 0.52 in the early predawn hours, and ranged from 0.08 0.01 during the day. All measured water activity values were below the level required for microbial growth or enzyme activity. Total organic carbon (TOC) levels in this region were just above the limits of detection and ranged from 220 660 μg/g of soil. Phospholipid fatty acid (PLFA) levels indicated cellular biomass ranging from 2 ×105 to 7 ×106 cell equivalents per gram of soil. The culturable counts were low with most samples showing no growth on standard plates of R2A medium; the highest single count was 47 colony forming units (CFU) per gram.

  3. Priority Directions of The Regional Food Complex Effectiveness Increase

    Directory of Open Access Journals (Sweden)

    Dmitry Andreyevich Karkh

    2015-06-01

    Full Text Available In the article, the modern trends of management integration as a solution of food and sectoral problems are considered. On the basis of national and foreign experience of development of integration, the classification of integration in economic systems is developed. On the basis of the given classification, the concept of integration is conducted. In the article, much attention is given to the food problem solution, which depends more on the agro-industrial complex based on metaintegration. The leading place of a food complex in the system of agro-industrial complex is caused by a role of food and food raw materials in life of the population of the country. The ratio of the sectors participating in the food production and consumer goods makes the sectoral structure of agro-industrial complex. In the conditions of the resource limitation necessary for the production and food delivery to the domestic market, the role of trade will increase not only in agro-industrial complex, but in all national economy. Also, in this article, the phenomenon of clusters is studied. The attention to clusters as to innovation systems reflects a rising tide of interest of economic science to the questions of economics functioning in regional level and understanding of a role of specific local resources in stimulation of innovative opportunities and competitiveness of small and medium business. Creating a cluster, participants develop the spatial and organizational integrated structure, in interaction of legal entities the status is saved and cooperation provides competitive advantages with other business entities. The role of the state in integration of cluster formations in the Russian Federation is more significant, than in any other country. The state represented by regional authorities actively participates in decision-making process by the business located in its catchment area not only through membership in governing bodies of large joint stock companies.

  4. Blood parasites shape extreme major histocompatibility complex diversity in a migratory passerine.

    Science.gov (United States)

    Biedrzycka, Aleksandra; Bielański, Wojciech; Ćmiel, Adam; Solarz, Wojciech; Zając, Tadeusz; Migalska, Magdalena; Sebastian, Alvaro; Westerdahl, Helena; Radwan, Jacek

    2018-06-01

    Pathogens are one of the main forces driving the evolution and maintenance of the highly polymorphic genes of the vertebrate major histocompatibility complex (MHC). Although MHC proteins are crucial in pathogen recognition, it is still poorly understood how pathogen-mediated selection promotes and maintains MHC diversity, and especially so in host species with highly duplicated MHC genes. Sedge warblers (Acrocephalus schoenobaenus) have highly duplicated MHC genes, and using data from high-throughput MHC genotyping, we were able to investigate to what extent avian malaria parasites explain temporal MHC class I supertype fluctuations in a long-term study population. We investigated infection status and infection intensities of two different strains of Haemoproteus, that is avian malaria parasites that are known to have significant fitness consequences in sedge warblers. We found that prevalence of avian malaria in carriers of specific MHC class I supertypes was a significant predictor of their frequency changes between years. This finding suggests that avian malaria infections partly drive the temporal fluctuations of the MHC class I supertypes. Furthermore, we found that individuals with a large number of different supertypes had higher resistance to avian malaria, but there was no evidence for an optimal MHC class I diversity. Thus, the two studied malaria parasite strains appear to select for a high MHC class I supertype diversity. Such selection may explain the maintenance of the extremely high number of MHC class I gene copies in sedge warblers and possibly also in other passerines where avian malaria is a common disease. © 2018 John Wiley & Sons Ltd.

  5. Complex layered dental restorations: Are they recognizable and do they survive extreme conditions?

    Science.gov (United States)

    Soon, Alistair S; Bush, Mary A; Bush, Peter J

    2015-09-01

    Recent research has shown that restorative dental materials can be recognized by microscopy and elemental analysis (scanning electron microscopy/energy dispersive X-ray spectroscopy and X-ray fluorescence; SEM/EDS and XRF) and that this is possible even in extreme conditions, such as cremation. These analytical methods and databases of dental materials properties have proven useful in DVI (disaster victim identification) of a commercial plane crash in 2009, and in a number of other victim identification cases. Dental materials appear on the market with ever expanding frequency. With their advent, newer methods of restoration have been proposed and adopted in the dental office. Methods might include placing multiple layers of dental materials, where they have different properties including adhesion, viscosity, or working time. These different dental materials include filled adhesives, flowable resins, glass ionomer cements, composite resins, liners and sealants. With possible combinations of different materials in these restorations, the forensic odontologist is now confronted with a new difficulty; how to recognize each individual material. The question might be posed if it is even possible to perform this task. Furthermore, an odontologist might be called upon to identify a victim under difficult circumstances, such as when presented with fragmented or incinerated remains. In these circumstances the ability to identify specific dental materials could assist in the identification of the deceased. Key to use of this information is whether these new materials and methods are detailed in the dental chart. Visual or radiographic inspection may not reveal the presence of a restoration, let alone the possible complex nature of that restoration. This study demonstrates another scientific method in forensic dental identification. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Dynamical downscaling of ERA-40 in complex terrain using the WRF regional climate model

    Energy Technology Data Exchange (ETDEWEB)

    Heikkilae, U. [Bjerknes Centre for Climate Research, Uni Bjerknes Centre, Bergen (Norway); Sandvik, A. [Bjerknes Centre for Climate Research, Institute for Marine Research (IMR), Bergen (Norway); Sorteberg, A. [University of Bergen, Geophysical Institute, Bergen (Norway)

    2011-10-15

    Results from a first-time employment of the WRF regional climate model to climatological simulations in Europe are presented. The ERA-40 reanalysis (resolution 1 ) has been downscaled to a horizontal resolution of 30 and 10 km for the period of 1961-1990. This model setup includes the whole North Atlantic in the 30 km domain and spectral nudging is used to keep the large scales consistent with the driving ERA-40 reanalysis. The model results are compared against an extensive observational network of surface variables in complex terrain in Norway. The comparison shows that the WRF model is able to add significant detail to the representation of precipitation and 2-m temperature of the ERA-40 reanalysis. Especially the geographical distribution, wet day frequency and extreme values of precipitation are highly improved due to the better representation of the orography. Refining the resolution from 30 to 10 km further increases the skill of the model, especially in case of precipitation. Our results indicate that the use of 10-km resolution is advantageous for producing regional future climate projections. Use of a large domain and spectral nudging seems to be useful in reproducing the extreme precipitation events due to the better resolved synoptic scale features over the North Atlantic, and also helps to reduce the large regional temperature biases over Norway. This study presents a high-resolution, high-quality climatological data set useful for reference climate impact studies. (orig.)

  7. The Ways of Preventing Students’ Extremism and Intolerance in the Regional Educational Institutions

    Directory of Open Access Journals (Sweden)

    O. A. Selivanova

    2012-01-01

    Full Text Available  The paper reveals the inefficiency problem of preventive measures controlling students’ intolerant and extremist behavior in higher educational institutions. According to the author, such trends in students’ society, as well as the rising phenomenon of nationalistic religious identity inevitably leading to interpersonal tensions, are caused in the last decades by the degrading prestige of higher education, growing pragmatism and formality of its achievement and key value depreciation in higher educational institutions. To improve the existing situation, it is necessary to revive the main functions of higher educational establishments –the intellectual and professional elite formation, cherishing the humanity values, social responsibility and active civil position; on the other hand, it is vitally important to create the system of prevention and correction of such trends as intolerance and extremism. However, the above goals are aggravated by the number of other problems listed in the paper.The method of developing the system of complex prevention of the mentioned negative phenomena is proposed with the reference to higher educational institutions; the specific stages of the given method, the technologies and organizational forms being outlined; the practical application and outcome in Tyumen State University being discussed. The research findings can be interesting for people responsible for preventive measures in higher educational instinutionms. 

  8. Venipuncture-Induced Complex Regional Pain Syndrome: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Foad Elahi

    2014-01-01

    Full Text Available Venipuncture, the most frequently performed invasive medical procedure, is usually benign. Generally it produces only transitory mild discomfort. Venipuncture-induced neuropathic pain is hard to recognize at an early stage. Medical literature reviews show that there is not adequate medical knowledge about this important subject. The inciting incident in complex regional pain syndrome (CRPS can often seem far too trivial to result in a condition with such severe pathophysiologic effects. The practicing physician has little information available to enable early recognition of the condition, initiation of multidisciplinary treatment modalities, and proper referral to pain specialists. We encountered a unique case of venipuncture-induced complex regional pain syndrome (CRPS. The patient is a 52-year-old school teacher with no significant past medical history, who presented initially to the Center of Pain Medicine with left upper extremity pain. The pain started while phlebotomy was performed in the patient’s left antecubital area for routine blood check. The patient’s pain did not improve with multiple medications, physical therapy, or several nerve blocks. The patient demonstrated all the signs and symptoms of chronic neuropathic pain of CRPS in the upper extremity with minimal response to the continuous pain management. We decided to proceed with cervical spinal cord nerve stimulation along with continuing other modalities. The patient responded to this combination. During the follow-up, we noticed that the patient’s pain course was complicated by extension of the CRPS to her lower extremity. We will describe the course of treatment for the patient in this paper. In this paper we will discuss the electrical neuromodulation as an important modality in addition to the multidisciplinary pain management for a patient with venipuncture-induced chronic neuropathic pain.

  9. Regional frequency analysis of short duration rainfall extremes using gridded daily rainfall data as co-variate

    DEFF Research Database (Denmark)

    Madsen, H.; Gregersen, Ida Bülow; Rosbjerg, Dan

    2017-01-01

    with daily measurements. The Poisson rate is positively correlated to the mean annual precipitation for all durations considered (1 min to 48 hours). The mean intensity can be assumed constant over Denmark for durations up to 1 hour. For durations larger than 1 hour the mean intensity is significantly...... correlated to the mean extreme daily precipitation. A Generalised Pareto distribution with a regional constant shape parameter is adopted. Compared to previous regional studies in Denmark a general increase in extreme rainfall intensity for durations up to 1 hour is found, whereas for larger durations both...

  10. [Effects of therapeutic complexes including balneoradonokinesitherapy, electromyostimulation and low-frequency magnetotherapy on regional blood flow in patients with postrraumatic gonarthritis].

    Science.gov (United States)

    Raspopova, E A; Udartsev, E Iu

    2006-01-01

    Balneoradonokinesitherapy alone and its combination with electrostimulation and low-frequency magnetotherapy were used for the treatment of regional blood flow disorders in 76 patients with posttraumatic gonarthritis. Balneoradonokinesitherapy in combination with electromyostimulation improved blood circulation. When low-frequency magnetotherapy was added to the latter complex, the regress of regional blood flow disorders of a damaged extremity was most significant.

  11. Security Inequalities in North America: Reassessing Regional Security Complex Theory

    Directory of Open Access Journals (Sweden)

    Richard Kilroy

    2017-12-01

    Full Text Available This article re-evaluates earlier work done by the authors on Regional Security Complex Theory (RSCT in North America, using sectoral analysis initially developed by Buzan and Waever, but also adding the variables of institutions, identity, and interests. These variables are assessed qualitatively in the contemporary context on how they currently impress upon the process of securitization within sectoral relations between Canada, Mexico, and the United States. The article reviews the movement from bilateral security relations between these states to the development of a trilateral response to regional security challenges post- 9/11. It further addresses the present period and what appears to be a security process derailed by recent political changes and security inequalities, heightened by the election of Donald Trump in 2016. The article argues that while these three states initially evinced a convergence of regional security interests after 9/11, which did create new institutional responses, under the current conditions, divergence in political interests and security inequalities have reduced the explanatory power of RSCT in North America. Relations between states in North American are becoming less characterized by the role of institutions and interests and more by identity politics in the region.

  12. Response identification in the extremely low frequency region of an electret condenser microphone.

    Science.gov (United States)

    Jeng, Yih-Nen; Yang, Tzung-Ming; Lee, Shang-Yin

    2011-01-01

    This study shows that a small electret condenser microphone connected to a notebook or a personal computer (PC) has a prominent response in the extremely low frequency region in a specific environment. It confines most acoustic waves within a tiny air cell as follows. The air cell is constructed by drilling a small hole in a digital versatile disk (DVD) plate. A small speaker and an electret condenser microphone are attached to the two sides of the hole. Thus, the acoustic energy emitted by the speaker and reaching the microphone is strong enough to actuate the diaphragm of the latter. The experiments showed that, once small air leakages are allowed on the margin of the speaker, the microphone captured the signal in the range of 0.5 to 20 Hz. Moreover, by removing the plastic cover of the microphone and attaching the microphone head to the vibration surface, the low frequency signal can be effectively captured too. Two examples are included to show the convenience of applying the microphone to pick up the low frequency vibration information of practical systems.

  13. Response Identification in the Extremely Low Frequency Region of an Electret Condenser Microphone

    Directory of Open Access Journals (Sweden)

    Shang-Yin Lee

    2011-01-01

    Full Text Available This study shows that a small electret condenser microphone connected to a notebook or a personal computer (PC has a prominent response in the extremely low frequency region in a specific environment. It confines most acoustic waves within a tiny air cell as follows. The air cell is constructed by drilling a small hole in a digital versatile disk (DVD plate. A small speaker and an electret condenser microphone are attached to the two sides of the hole. Thus, the acoustic energy emitted by the speaker and reaching the microphone is strong enough to actuate the diaphragm of the latter. The experiments showed that, once small air leakages are allowed on the margin of the speaker, the microphone captured the signal in the range of 0.5 to 20 Hz. Moreover, by removing the plastic cover of the microphone and attaching the microphone head to the vibration surface, the low frequency signal can be effectively captured too. Two examples are included to show the convenience of applying the microphone to pick up the low frequency vibration information of practical systems.

  14. Longitudinal Regional Brain Development and Clinical Risk Factors in Extremely Preterm Infants.

    Science.gov (United States)

    Kersbergen, Karina J; Makropoulos, Antonios; Aljabar, Paul; Groenendaal, Floris; de Vries, Linda S; Counsell, Serena J; Benders, Manon J N L

    2016-11-01

    To investigate third-trimester extrauterine brain growth and correlate this with clinical risk factors in the neonatal period, using serially acquired brain tissue volumes in a large, unselected cohort of extremely preterm born infants. Preterm infants (gestational age regions covering the entire brain. Multivariable regression analysis was used to determine the influence of clinical variables on volumes at both scans, as well as on volumetric growth. MRIs at term equivalent age were available for 210 infants and serial data were available for 131 infants. Growth over these 10 weeks was greatest for the cerebellum, with an increase of 258%. Sex, birth weight z-score, and prolonged mechanical ventilation showed global effects on brain volumes on both scans. The effect of brain injury on ventricular size was already visible at 30 weeks, whereas growth data and volumes at term-equivalent age revealed the effect of brain injury on the cerebellum. This study provides data about third-trimester extrauterine volumetric brain growth in preterm infants. Both global and local effects of several common clinical risk factors were found to influence serial volumetric measurements, highlighting the vulnerability of the human brain, especially in the presence of brain injury, during this period. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. WEAK LINE QUASARS AT HIGH REDSHIFT: EXTREMELY HIGH ACCRETION RATES OR ANEMIC BROAD-LINE REGIONS?

    International Nuclear Information System (INIS)

    Shemmer, Ohad; Trakhtenbrot, Benny; Netzer, Hagai; Anderson, Scott F.; Brandt, W. N.; Schneider, Donald P.; Diamond-Stanic, Aleksandar M.; Fan Xiaohui; Lira, Paulina; Plotkin, Richard M.; Richards, Gordon T.; Strauss, Michael A.

    2010-01-01

    We present Gemini-North K-band spectra of two representative members of the class of high-redshift quasars with exceptionally weak rest-frame ultraviolet emission lines (WLQs), SDSS J114153.34+021924.3 at z = 3.55 and SDSS J123743.08+630144.9 at z = 3.49. In both sources, we detect an unusually weak broad Hβ line and place tight upper limits on the strengths of their [O III] lines. Virial, Hβ-based black hole mass determinations indicate normalized accretion rates of L/L Edd =0.4 for these sources, which is well within the range observed for typical quasars with similar luminosities and redshifts. We also present high-quality XMM-Newton imaging spectroscopy of SDSS J114153.34+021924.3 and find a hard-X-ray photon index of Γ = 1.91 +0.24 -0.22 , which supports the virial L/L Edd determination in this source. Our results suggest that the weakness of the broad emission lines in WLQs is not a consequence of an extreme continuum-emission source but instead due to abnormal broad emission line region properties.

  16. Rapid Global River Flood Risk Assessment under Climate and Socioeconomic Scenarios: An Extreme Case of Eurasian region

    Science.gov (United States)

    Kwak, Young-joo; Magome, Jun; Hasegawa, Akira; Iwami, Yoichi

    2017-04-01

    Causing widespread devastation with massive economic damage and loss of human lives, flood disasters hamper economic growth and accelerate poverty particularly in developing countries. Globally, this trend will likely continue due to increase in flood magnitude and lack of preparedness for extreme events. In line with risk reduction efforts since the early 21st century, the monitors and governors of global river floods should pay attention to international scientific and policy communities for support to facilitate evidence-based policy making with a special interest in long-term changes due to climate change and socio-economic effects. Although advanced hydrological inundation models and risk models have been developed to reveal flood risk, hazard, exposure, and vulnerability at a river basin, it is obviously hard to identify the distribution and locations of continent-level flood risk based on national-level data. Therefore, we propose a methodological possibility for rapid global flood risk assessment with the results from its application to the two periods, i.e., Present (from 1980 to 2004) and Future (from 2075 to 2099). The method is particularly designed to effectively simplify complexities of a hazard area by calculating the differential inundation depth using GFID2M (global flood inundation depth 2-dimension model), despite low data availability. In this research, we addressed the question of which parts in the Eurasian region (8E to 180E, 0N to 60N) can be found as high-risk areas in terms of exposed population and economy in case of a 50-year return period flood. Economic losses were estimated according to the Shared Socioeconomic Pathways (SSP) scenario, and the flood scale was defined using the annual maximum daily river discharge under the extreme conditions of climate change simulated with MRI-AGCM3.2S based on the Representative Concentration Pathways (RCP8.5) emissions scenario. As a preliminary result, the total potential economic loss in the

  17. Assessing the Adequacy of Probability Distributions for Estimating the Extreme Events of Air Temperature in Dabaa Region

    International Nuclear Information System (INIS)

    El-Shanshoury, Gh.I.

    2015-01-01

    Assessing the adequacy of probability distributions for estimating the extreme events of air temperature in Dabaa region is one of the pre-requisite s for any design purpose at Dabaa site which can be achieved by probability approach. In the present study, three extreme value distributions are considered and compared to estimate the extreme events of monthly and annual maximum and minimum temperature. These distributions include the Gumbel/Frechet distributions for estimating the extreme maximum values and Gumbel /Weibull distributions for estimating the extreme minimum values. Lieblein technique and Method of Moments are applied for estimating the distribution para meters. Subsequently, the required design values with a given return period of exceedance are obtained. Goodness-of-Fit tests involving Kolmogorov-Smirnov and Anderson-Darling are used for checking the adequacy of fitting the method/distribution for the estimation of maximum/minimum temperature. Mean Absolute Relative Deviation, Root Mean Square Error and Relative Mean Square Deviation are calculated, as the performance indicators, to judge which distribution and method of parameters estimation are the most appropriate one to estimate the extreme temperatures. The present study indicated that the Weibull distribution combined with Method of Moment estimators gives the highest fit, most reliable, accurate predictions for estimating the extreme monthly and annual minimum temperature. The Gumbel distribution combined with Method of Moment estimators showed the highest fit, accurate predictions for the estimation of the extreme monthly and annual maximum temperature except for July, August, October and November. The study shows that the combination of Frechet distribution with Method of Moment is the most accurate for estimating the extreme maximum temperature in July, August and November months while t he Gumbel distribution and Lieblein technique is the best for October

  18. Changes in extreme regional sea surface height due to an abrupt weakening of the Atlantic meridional overturning circulation

    NARCIS (Netherlands)

    Brunnabend, S.-E.; Dijkstra, H. A.; Kliphuis, M. A.; van Werkhoven, B.J.C.; Bal, H. E.; Seinstra, F.; Maassen, J.; van Meersbergen, M.

    2014-01-01

    As an extreme scenario of dynamical sea level changes, regional sea surface height (SSH) changes that occur in the North Atlantic due to an abrupt weakening of the Atlantic meridional overturning circulation (AMOC) are simulated. Two versions of the same ocean-only model are used to study the effect

  19. Future changes in extreme precipitation in the Rhine basin based on global and regional climate model simulations

    NARCIS (Netherlands)

    Pelt, van S.C.; Beersma, J.J.; Buishand, T.A.; Hurk, van den B.J.J.M.; Kabat, P.

    2012-01-01

    Probability estimates of the future change of extreme precipitation events are usually based on a limited number of available global climate model (GCM) or regional climate model (RCM) simulations. Since floods are related to heavy precipitation events, this restricts the assessment of flood risks.

  20. Low complexity iterative MLSE equalization of M-QAM signals in extremely long rayleigh fading channels

    CSIR Research Space (South Africa)

    Myburgh, HC

    2009-05-01

    Full Text Available long channels. Its computational complexity is linear in the data block length and approximately independent of the channel memory length, whereas conventional equalization algorithms have computational complexity linear in the data block length...

  1. Computational intelligence-based optimization of maximally stable extremal region segmentation for object detection

    Science.gov (United States)

    Davis, Jeremy E.; Bednar, Amy E.; Goodin, Christopher T.; Durst, Phillip J.; Anderson, Derek T.; Bethel, Cindy L.

    2017-05-01

    Particle swarm optimization (PSO) and genetic algorithms (GAs) are two optimization techniques from the field of computational intelligence (CI) for search problems where a direct solution can not easily be obtained. One such problem is finding an optimal set of parameters for the maximally stable extremal region (MSER) algorithm to detect areas of interest in imagery. Specifically, this paper describes the design of a GA and PSO for optimizing MSER parameters to detect stop signs in imagery produced via simulation for use in an autonomous vehicle navigation system. Several additions to the GA and PSO are required to successfully detect stop signs in simulated images. These additions are a primary focus of this paper and include: the identification of an appropriate fitness function, the creation of a variable mutation operator for the GA, an anytime algorithm modification to allow the GA to compute a solution quickly, the addition of an exponential velocity decay function to the PSO, the addition of an "execution best" omnipresent particle to the PSO, and the addition of an attractive force component to the PSO velocity update equation. Experimentation was performed with the GA using various combinations of selection, crossover, and mutation operators and experimentation was also performed with the PSO using various combinations of neighborhood topologies, swarm sizes, cognitive influence scalars, and social influence scalars. The results of both the GA and PSO optimized parameter sets are presented. This paper details the benefits and drawbacks of each algorithm in terms of detection accuracy, execution speed, and additions required to generate successful problem specific parameter sets.

  2. Regional anesthesia procedures for shoulder and upper arm surgery upper extremity update--2005 to present.

    Science.gov (United States)

    Sripada, Ramprasad; Bowens, Clifford

    2012-01-01

    This review of the literature since 2005 assesses developments of RA techniques commonly used for shoulder surgery, and their effectiveness for postoperative analgesia. Advantages of regional techniques include site-specific anesthesia and decreased postoperative opioid use. For shoulder surgeries, the ISB provides effective analgesia with minimal complications, whereas the impacts of IA single-injections remain unclear. When combined with GA, ISB can be used in lower volumes and reducing the complications for shoulder and proximal upper extremity. USG ISB and SCB are both effective and safe for shoulder surgery with a low incidence of complications, especially PONS.53 When compared with intravenous patient-controlled opioid analgesia, a perineural LA infusion using a disposable pump with patient-controlled LA bolus function has led to better pain relief and functional recovery while decreasing the need for rescue analgesics and the number of adverse events after ambulatory orthopedic surgery. The most remarkable advance in RA in the past 5 years is the increased usage of USG. Although there are no large-scale prospective studies to show the safety, efficacy, and success and complication rates for USG blocks, USG RA theoretically could have less risk for neurologic symptoms, except for those induced by LA (less likely perineurally, much more likely intraneurally). The next "quantum leap" lies in reducing LA concentrations and augmenting anesthetic-analgesic effects with perineural additives (including clonidine, buprenorphine, and likely low-dose dexamethasone). Since 2005, perineural catheters have been an analgesic option that offers improved pain relief among other benefits, and are now being used at home. It is clear that patients benefit greatly from a single injection and continuous nerve block for postoperative pain management,but the financial and logistical aspects need to be resolved, not to mention the phrenic hemiparesis coin toss. Whether combined

  3. Complex regional pain syndrome type I following pacemaker implantation

    Directory of Open Access Journals (Sweden)

    Sangita Kamath

    2015-12-01

    Full Text Available A 70-year-old woman presented with burning pain and swelling over dorsum of right hand and small joints of the fingers, associated with redness, feeling of warmth, and stiffness of the fingers, with inability to bend the fingers since 2 months. The symptoms were progressively increasing in intensity for the past 1 month. There was no history of fever or trauma to the hand. Two months before her symptoms started, she had permanent pacemaker implanted for complete heart block with syncope. She was hypertensive and was on regular medication. Her X-ray of right hand showed decreased bone density (demineralisation, suggestive of osteopenia. A diagnosis of reflex sympathetic dystrophy syndrome or complex regional pain syndrome type I induced by pacemaker insertion was made. She was treated with amitriptyline and steroids, after which her symptoms improved dramatically.

  4. Immunological aspects of the complex regional pain syndrome (CRPS).

    Science.gov (United States)

    Krämer, Heidrun H

    2012-01-01

    Limb trauma can lead to the development of a complex regional pain syndrome (CRPS). CRPS is a descriptive term of a variety of different symptoms. According to the current IASP-approved criteria, human CRPS can be diagnosed if a combination of signs is present: continuing pain and hyperalgesia, disproportionate to the initial trauma, skin temperature and colour asymmetry, sweating asymmetry, edema, decreased range of motion, and trophic changes. The diagnosis and treatment of human CRPS can be demanding and the pathophysiology underlying the disease is still under investigation. Immunological aspects are considered to play an important role in the development of CRPS. The impact of elevated pro-inflammatory cytokines systemically as well as locally, increased neurogenic inflammation and auto-antibodies in the pathophysiological development of CRPS are discussed in this review.

  5. A comparison of observed extreme water levels at the German Bight elaborated through an extreme value analysis (EVA) with extremes derived from a regionally coupled ocean-atmospheric climate model (MPI-OM)

    Science.gov (United States)

    Möller, Jens; Heinrich, Hartmut

    2017-04-01

    As a consequence of climate change atmospheric and oceanographic extremes and their potential impacts on coastal regions are of growing concern for governmental authorities responsible for the transportation infrastructure. Highest risks for shipping as well as for rail and road traffic originate from combined effects of extremes of storm surges and heavy rainfall which sometimes lead to insufficient dewatering of inland waterways. The German Ministry of Transport and digital Infrastructure therefore has tasked its Network of Experts to investigate the possible evolutions of extreme threats for low lands and especially for Kiel Canal, which is an important shortcut for shipping between the North and Baltic Seas. In this study we present results of a comparison of an Extreme Value Analysis (EVA) carried out on gauge observations and values derived from a coupled Regional Ocean-Atmosphere Climate Model (MPI-OM). High water levels at the coasts of the North and Baltic Seas are one of the most important hazards which increase the risk of flooding of the low-lying land and prevents such areas from an adequate dewatering. In this study changes in the intensity (magnitude of the extremes) and duration of extreme water levels (above a selected threshold) are investigated for several gauge stations with data partly reaching back to 1843. Different methods are used for the extreme value statistics, (1) a stationary general Pareto distribution (GPD) model as well as (2) an instationary statistical model for better reproduction of the impact of climate change. Most gauge stations show an increase of the mean water level of about 1-2 mm/year, with a stronger increase of the highest water levels and a decrease (or lower increase) of the lowest water levels. Also, the duration of possible dewatering time intervals for the Kiel-Canal was analysed. The results for the historical gauge station observations are compared to the statistics of modelled water levels from the coupled

  6. Trends in Cold Extremes and Winter Weather for the SPTC Region

    Science.gov (United States)

    2017-05-31

    Extreme weather poses multifaceted hazards to transportation. There is now increased awareness of the threats of climate variability and change on transportation safety and state of good repair. In particular, a non-stationary climate will potentiall...

  7. Evidence based guidelines for complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Thomassen-Hilgersom Ilona L

    2010-03-01

    Full Text Available Abstract Background Treatment of complex regional pain syndrome type I (CRPS-I is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I. Method A multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according to their strength of evidence, published between 1980 to June 2005. Treatment recommendations based on the literature findings were formulated and formally approved by all Dutch professional associations involved in CRPS-I treatment. Results For pain treatment, the WHO analgesic ladder is advised with the exception of strong opioids. For neuropathic pain, anticonvulsants and tricyclic antidepressants may be considered. For inflammatory symptoms, free-radical scavengers (dimethylsulphoxide or acetylcysteine are advised. To promote peripheral blood flow, vasodilatory medication may be considered. Percutaneous sympathetic blockades may be used to increase blood flow in case vasodilatory medication has insufficient effect. To decrease functional limitations, standardised physiotherapy and occupational therapy are advised. To prevent the occurrence of CRPS-I after wrist fractures, vitamin C is recommended. Adequate perioperative analgesia, limitation of operating time, limited use of tourniquet, and use of regional anaesthetic techniques are recommended for secondary prevention of CRPS-I. Conclusions Based on the literature identified and the extent of evidence found for therapeutic interventions for CRPS-I, we conclude that further research is needed into each of the therapeutic modalities discussed in the guidelines.

  8. Regional and Household Adaptation Strategies to Climate Extremes: the Case Study of the Beava River Basin, the Czech Republic

    Science.gov (United States)

    Duží, Barbora; Stojanov, Robert; Vikhrov, Dmytro

    2013-04-01

    We investigate regional and household adaptation strategies in the region affected by climate extremes, focusing on floods occurrence during past 15 years period. The main research question is: What is the overall state of adaptation measurements to climate extremes on the Bečva river basin? Target area is located along upper and middle part of the Bečva river basin in the east of the Czech Republic. The main theoretical concepts draw from differentiations between coping/adaptation strategies to climate extremes and theory of focusing event as a starter of changes in attention and agenda of problem solution. We apply mixed empirical research and case study approach. First we use qualitative research to serve as an initial entrance to the issue, to find out the perception of adaptation progress and preparedness to climate extremes on regional level. We conducted deep interviews (N=20) with relevant stakeholders. We proceed with quantitative research through the conducting face-to face questionnaires with household residents (N=305) in no, low and no risk area in relation to flood occurrence. We designed set of questions to find out relation among experiences with flood, the level of damages and applied emergency and adaptation measurements.

  9. Multifractal analysis of forest fires in complex regions

    Science.gov (United States)

    Vega Orozco, C. D.; Kanevski, M.; Golay, J.; Tonini, M.; Conedera, M.

    2012-04-01

    Forest fires can be studied as point processes where the ignition points represent the set of locations of the observed events in a defined study region. Their spatial and temporal patterns can be characterized by their fractal properties; which quantify the global aspect of the geometry of the support data. However, a monofractal dimension can not completely describe the pattern structure and related scaling properties. Enhancements in fractal theory had developed the multifractal concept which describes the measures from which interlinked fractal sets can be retrieved and characterized by their fractal dimension and singularity strength [1, 2]. The spatial variability of forest fires is conditioned by an intermixture of human, topographic, meteorological and vegetation factors. This heterogeneity makes fire patterns complex scale-invariant processes difficult to be depicted by a single scale. Therefore, this study proposes an exploratory data analysis through a multifractal formalism to characterize and quantify the multiscaling behaviour of the spatial distribution pattern of this phenomenon in a complex region like the Swiss Alps. The studied dataset is represented by 2,401 georeferenced forest fire ignition points in canton Ticino, Switzerland, in a 40-years period from 1969 to 2008. Three multifractal analyses are performed: one assesses the multiscaling behaviour of fire occurrence probability of the support data (raw data) and four random patterns simulated within three different support domains; second analysis studies the multifractal behavior of patterns from anthropogenic and natural ignited fires (arson-, accident- and lightning-caused fires); and third analysis aims at detecting scale-dependency of the size of burned area. To calculate the generalized dimensions, Dq, a generalization of the box counting methods is carried out based on the generalization of Rényi information of the qth order moment of the probability distribution. For q > 0, Dq

  10. Cambrian nepheline syenite complex at Jabal Sawda, Midyan region, Kingdom of Saudi Arabia

    Science.gov (United States)

    Liddicoat, W.K.; Ramsay, C.R.; Hedge, C.E.

    1986-01-01

    The only nepheline syenite complex presently known in the Arabian Shield is at Jabal Sawda, about 30 km S of Haql in the extreme NW of Saudi Arabia. It is a post-tectonic, composite intrusion with a crudely concentric structure. A core of leuco-nepheline syenite, a partial ring of mela-nepheline syenite, and an almost complete outer ring of alkali-feldspar syenite are the main rock units. Several mega-inclusions of porphyritic nepheline syenite, nepheline monzosyenite, malignite and ijolite are present in the leuco-nepheline syenite. The chemical composition is notable for very high values of Al2O3, Na2O, Ba, La, Nb, Sr and Zr. U{single bond}Pb isotope dating indicates an emplacement age of 553 ?? 4 Ma, one of an increasing number of reliable Cambrian isotope dates in the northern Red Sea region. ?? 1986.

  11. Cambrian nepheline syenite complex at Jabal Sawda, Midyan region, Kingdom of Saudi Arabia

    Science.gov (United States)

    Liddicoat, W. K.; Ramsay, C. R.; Hedge, C. E.

    The only nepheline syenite complex presently known in the Arabian Shield is at Jabal Sawda, about 30 km S of Haql in the extreme NW of Saudi Arabia. It is a post-tectonic, composite intrusion with a crudely concentric structure. A core of leuco-nepheline syenite, a partial ring of mela-nepheline syenite, and an almost complete outer ring of alkali-feldspar syenite are the main rock units. Several mega-inclusions of porphyritic nepheline syenite, nepheline monzosyenite, malignite and ijolite are present in the leuco-nepheline syenite. The chemical composition is notable for very high values of Al 2O 3, Na 2O, Ba, La, Nb, Sr and Zr. U sbnd Pb isotope dating indicates an emplacement age of 553 ± 4 Ma, one of an increasing number of reliable Cambrian isotope dates in the northern Red Sea region.

  12. Validation of EURO-CORDEX regional climate models in reproducing the variability of precipitation extremes in Romania

    Science.gov (United States)

    Dumitrescu, Alexandru; Busuioc, Aristita

    2016-04-01

    EURO-CORDEX is the European branch of the international CORDEX initiative that aims to provide improved regional climate change projections for Europe. The main objective of this paper is to document the performance of the individual models in reproducing the variability of precipitation extremes in Romania. Here three EURO-CORDEX regional climate models (RCMs) ensemble (scenario RCP4.5) are analysed and inter-compared: DMI-HIRHAM5, KNMI-RACMO2.2 and MPI-REMO. Compared to previous studies, when the RCM validation regarding the Romanian climate has mainly been made on mean state and at station scale, a more quantitative approach of precipitation extremes is proposed. In this respect, to have a more reliable comparison with observation, a high resolution daily precipitation gridded data set was used as observational reference (CLIMHYDEX project). The comparison between the RCM outputs and observed grid point values has been made by calculating three extremes precipitation indices, recommended by the Expert Team on Climate Change Detection Indices (ETCCDI), for the 1976-2005 period: R10MM, annual count of days when precipitation ≥10mm; RX5DAY, annual maximum 5-day precipitation and R95P%, precipitation fraction of annual total precipitation due to daily precipitation > 95th percentile. The RCMs capability to reproduce the mean state for these variables, as well as the main modes of their spatial variability (given by the first three EOF patterns), are analysed. The investigation confirms the ability of RCMs to simulate the main features of the precipitation extreme variability over Romania, but some deficiencies in reproducing of their regional characteristics were found (for example, overestimation of the mea state, especially over the extra Carpathian regions). This work has been realised within the research project "Changes in climate extremes and associated impact in hydrological events in Romania" (CLIMHYDEX), code PN II-ID-2011-2-0073, financed by the Romanian

  13. Addressing the mischaracterization of extreme rainfall in regional climate model simulations - A synoptic pattern based bias correction approach

    Science.gov (United States)

    Li, Jingwan; Sharma, Ashish; Evans, Jason; Johnson, Fiona

    2018-01-01

    Addressing systematic biases in regional climate model simulations of extreme rainfall is a necessary first step before assessing changes in future rainfall extremes. Commonly used bias correction methods are designed to match statistics of the overall simulated rainfall with observations. This assumes that change in the mix of different types of extreme rainfall events (i.e. convective and non-convective) in a warmer climate is of little relevance in the estimation of overall change, an assumption that is not supported by empirical or physical evidence. This study proposes an alternative approach to account for the potential change of alternate rainfall types, characterized here by synoptic weather patterns (SPs) using self-organizing maps classification. The objective of this study is to evaluate the added influence of SPs on the bias correction, which is achieved by comparing the corrected distribution of future extreme rainfall with that using conventional quantile mapping. A comprehensive synthetic experiment is first defined to investigate the conditions under which the additional information of SPs makes a significant difference to the bias correction. Using over 600,000 synthetic cases, statistically significant differences are found to be present in 46% cases. This is followed by a case study over the Sydney region using a high-resolution run of the Weather Research and Forecasting (WRF) regional climate model, which indicates a small change in the proportions of the SPs and a statistically significant change in the extreme rainfall over the region, although the differences between the changes obtained from the two bias correction methods are not statistically significant.

  14. Downscaling wind and wavefields for 21st century coastal flood hazard projections in a region of complex terrain

    Science.gov (United States)

    O'Neill, Andrea; Erikson, Li; Barnard, Patrick

    2017-01-01

    While global climate models (GCMs) provide useful projections of near-surface wind vectors into the 21st century, resolution is not sufficient enough for use in regional wave modeling. Statistically downscaled GCM projections from Multivariate Adaptive Constructed Analogues provide daily averaged near-surface winds at an appropriate spatial resolution for wave modeling within the orographically complex region of San Francisco Bay, but greater resolution in time is needed to capture the peak of storm events. Short-duration high wind speeds, on the order of hours, are usually excluded in statistically downscaled climate models and are of key importance in wave and subsequent coastal flood modeling. Here we present a temporal downscaling approach, similar to constructed analogues, for near-surface winds suitable for use in local wave models and evaluate changes in wind and wave conditions for the 21st century. Reconstructed hindcast winds (1975–2004) recreate important extreme wind values within San Francisco Bay. A computationally efficient method for simulating wave heights over long time periods was used to screen for extreme events. Wave hindcasts show resultant maximum wave heights of 2.2 m possible within the Bay. Changes in extreme over-water wind speeds suggest contrasting trends within the different regions of San Francisco Bay, but 21th century projections show little change in the overall magnitude of extreme winds and locally generated waves.

  15. An empirical application of regional security complex theory on eastern partnership region

    Directory of Open Access Journals (Sweden)

    Ludmila STUPARU

    2015-12-01

    Full Text Available Eastern Partnership (EaP is a very dynamic region. If a year ago the EaP was seen as an authentic and vibrant „laboratory” of democracy building, overcoming the remains of the totalitarian state and putting the basis of a free and pluralist society, nowadays the Eastern Partnership is seen as an „out-dated” approach of the EU. However, Eastern Partnership is visible on European political arena and the big powers (USA, Russia and the EU pay attention more and more to the evolution of EaP countries. Moreover, it seems to be a confrontation between Russia and Western powers regarding the political and geopolitical orientation of EaP countries. Kremlin tries actively to stop the efforts of the EaP to close to the EU and on the other side, the EU as well as the USA encourage EaP countries to implement reforms in order to build their democracy. This paper aims to analyse the Eastern Partnership in terms of security complex, trying to argue that Eastern Partnership countries at this phase don’t form a Regional Security Complex and the EU and USA should rethink its approach towards this region.

  16. Extreme value analysis of air pollution data and their comparison between two large urban regions of South America

    Directory of Open Access Journals (Sweden)

    Leila Droprinchinski Martins

    2017-12-01

    Full Text Available Sixteen years of hourly atmospheric pollutant data (1996–2011 in the Metropolitan Area of São Paulo (MASP, and seven years (2005–2011 of data measured in the Metropolitan Area of Rio de Janeiro (MARJ, were analyzed in order to study the extreme pollution events and their return period. In addition, the objective was to compare the air quality between the two largest Brazilian urban areas and provide information for decision makers, government agencies and civil society. Generalized Extreme Value (GEV and Generalized Pareto Distribution (GPD were applied to investigate the behavior of pollutants in these two regions. Although GEV and GPD are different approaches, they presented similar results. The probability of higher concentrations for CO, NO, NO2, PM10 and PM2.5 was more frequent during the winter, and O3 episodes occur most frequently during summer in the MASP. On the other hand, there is no seasonally defined behavior in MARJ for pollutants, with O3 presenting the shortest return period for high concentrations. In general, Ibirapuera and Campos Elísios stations present the highest probabilities of extreme events with high concentrations in MASP and MARJ, respectively. When the regions are compared, MASP presented higher probabilities of extreme events for all analyzed pollutants, except for NO; while O3 and PM2.5 are those with most frequent probabilities of presenting extreme episodes, in comparison other pollutants. Keywords: Air pollutants, Extreme events, Megacities, Ozone, Particulate matter

  17. Complex regional pain syndrome–up-to-date

    Science.gov (United States)

    Birklein, Frank; Dimova, Violeta

    2017-01-01

    Abstract Complex regional pain syndrome (CRPS) was described for the first time in the 19th century by Silas Weir Mitchell. After the exclusion of other causes, CRPS is characterised by a typical clinical constellation of pain, sensory, autonomic, motor, or trophic symptoms which can no longer be explained by the initial trauma. These symptoms spread distally and are not limited to innervation territories. If CRPS is not improved in the acute phase and becomes chronic, the visible symptoms change throughout because of the changing pathophysiology; the pain, however, remains. The diagnosis is primarily clinical, although in complex cases further technical examination mainly for exclusion of alternative diagnoses is warranted. In the initial phase, the pathophysiology is dominated by a posttraumatic inflammatory reaction by the activation of the innate and adaptive immune system. In particular, without adequate treatment, central nociceptive sensitization, reorganisation, and implicit learning processes develop, whereas the inflammation moderates. The main symptoms then include movement disorders, alternating skin temperature, sensory loss, hyperalgesia, and body perception disturbances. Psychological factors such as posttraumatic stress or pain-related fear may impact the course and the treatability of CRPS. The treatment should be ideally adjusted to the pathophysiology. Pharmacological treatment maybe particularly effective in acute stages and includes steroids, bisphosphonates, and dimethylsulfoxide cream. Common anti-neuropathic pain drugs can be recommended empirically. Intravenous long-term ketamine administration has shown efficacy in randomised controlled trials, but its repeated application is demanding and has side effects. Important components of the treatment include physio- and occupational therapy including behavioural therapy (eg, graded exposure in vivo and graded motor imaging). If psychosocial comorbidities exist, patients should be appropriately

  18. Genome-wide expression profiling of complex regional pain syndrome.

    Directory of Open Access Journals (Sweden)

    Eun-Heui Jin

    Full Text Available Complex regional pain syndrome (CRPS is a chronic, progressive, and devastating pain syndrome characterized by spontaneous pain, hyperalgesia, allodynia, altered skin temperature, and motor dysfunction. Although previous gene expression profiling studies have been conducted in animal pain models, there genome-wide expression profiling in the whole blood of CRPS patients has not been reported yet. Here, we successfully identified certain pain-related genes through genome-wide expression profiling in the blood from CRPS patients. We found that 80 genes were differentially expressed between 4 CRPS patients (2 CRPS I and 2 CRPS II and 5 controls (cut-off value: 1.5-fold change and p<0.05. Most of those genes were associated with signal transduction, developmental processes, cell structure and motility, and immunity and defense. The expression levels of major histocompatibility complex class I A subtype (HLA-A29.1, matrix metalloproteinase 9 (MMP9, alanine aminopeptidase N (ANPEP, l-histidine decarboxylase (HDC, granulocyte colony-stimulating factor 3 receptor (G-CSF3R, and signal transducer and activator of transcription 3 (STAT3 genes selected from the microarray were confirmed in 24 CRPS patients and 18 controls by quantitative reverse transcription-polymerase chain reaction (qRT-PCR. We focused on the MMP9 gene that, by qRT-PCR, showed a statistically significant difference in expression in CRPS patients compared to controls with the highest relative fold change (4.0±1.23 times and p = 1.4×10(-4. The up-regulation of MMP9 gene in the blood may be related to the pain progression in CRPS patients. Our findings, which offer a valuable contribution to the understanding of the differential gene expression in CRPS may help in the understanding of the pathophysiology of CRPS pain progression.

  19. Complex regional pain syndrome–up-to-date

    Directory of Open Access Journals (Sweden)

    Frank Birklein

    2017-12-01

    Full Text Available Abstract. Complex regional pain syndrome (CRPS was described for the first time in the 19th century by Silas Weir Mitchell. After the exclusion of other causes, CRPS is characterised by a typical clinical constellation of pain, sensory, autonomic, motor, or trophic symptoms which can no longer be explained by the initial trauma. These symptoms spread distally and are not limited to innervation territories. If CRPS is not improved in the acute phase and becomes chronic, the visible symptoms change throughout because of the changing pathophysiology; the pain, however, remains. The diagnosis is primarily clinical, although in complex cases further technical examination mainly for exclusion of alternative diagnoses is warranted. In the initial phase, the pathophysiology is dominated by a posttraumatic inflammatory reaction by the activation of the innate and adaptive immune system. In particular, without adequate treatment, central nociceptive sensitization, reorganisation, and implicit learning processes develop, whereas the inflammation moderates. The main symptoms then include movement disorders, alternating skin temperature, sensory loss, hyperalgesia, and body perception disturbances. Psychological factors such as posttraumatic stress or pain-related fear may impact the course and the treatability of CRPS. The treatment should be ideally adjusted to the pathophysiology. Pharmacological treatment maybe particularly effective in acute stages and includes steroids, bisphosphonates, and dimethylsulfoxide cream. Common anti-neuropathic pain drugs can be recommended empirically. Intravenous long-term ketamine administration has shown efficacy in randomised controlled trials, but its repeated application is demanding and has side effects. Important components of the treatment include physio- and occupational therapy including behavioural therapy (eg, graded exposure in vivo and graded motor imaging. If psychosocial comorbidities exist, patients should

  20. Evolution in Intensity and Frequency of Extreme Events of Precipitation in Northeast Region and Brazilian Amazon in XXI Century

    Science.gov (United States)

    Fonseca, P. M.; Veiga, J. A.; Correia, F. S.; Brito, A. L.

    2013-05-01

    The aim of this research was evaluate changes in frequency and intensity of extreme events of precipitation in Brazilian Amazon and Northeast Region, doubling CO2 concentration in agreement of IPCC A2 emissions scenarios (Nakicenovic et al., 2001). For this evaluation was used ETA model (Chou et al., 2011), forced with CCSM3 Global model data (Meehl, 2006) to run 4 experiments, only for January, February and March: 1980-1990, 2000-2010, 2040-2050 and 2090-2100. Using the first decade as reference (1980-1990), was evaluated changes occurred in following decades, with a methodology to classify extremes events adapted from Frich (2002) and Gao (2006). Higher was the class, more intense is the event. An increase of 25% was observed in total precipitation in Brazilian Amazon for the end of XXI century and 12% for extreme events type 1, 9% for events type 2 and 10% for type 3. By the other hand, a 17% decrease of precipitation in Brazilian Northeast was observed, and a pronounced decay of 24% and 15% in extreme events contribution type 1 and 2 to total amount of precipitation, respectively. The difference between total normal type events was positive in this three decades compared with reference decade 1980-1990, varying positively from 4 to 6 thousand events included in normality by decade, these events was decreased in your majority of Class 1 events, which presented a decay of at least 3.500 events by each decade. This suggests an intensification of extreme events, considering that the amount of precipitation by class increased, and the number of events by class decreased. To Northeast region, an increasing in 9% of contribution to events type 3 class was observed, as well as in the frequency of this type of events (about of 700 more events). Major decreasing in number of classes extreme events occur in 2000-2010, to classes 1 and 3, with 7,2 and 5,6%, and by the end of century in class 3, with 4,5%. For the three analyzed decades a total decrease of 8.400 events was

  1. Assessment of climate change impact on hydrological extremes in two source regions of the Nile River Basin

    Directory of Open Access Journals (Sweden)

    M. T. Taye

    2011-01-01

    Full Text Available The potential impact of climate change was investigated on the hydrological extremes of Nyando River and Lake Tana catchments, which are located in two source regions of the Nile River basin. Climate change scenarios were developed for rainfall and potential evapotranspiration (ETo, considering 17 General Circulation Model (GCM simulations to better understand the range of possible future change. They were constructed by transferring the extracted climate change signals to the observed series using a frequency perturbation downscaling approach, which accounts for the changes in rainfall extremes. Projected changes under two future SRES emission scenarios A1B and B1 for the 2050s were considered. Two conceptual hydrological models were calibrated and used for the impact assessment. Their difference in simulating the flows under future climate scenarios was also investigated.

    The results reveal increasing mean runoff and extreme peak flows for Nyando catchment for the 2050s while unclear trend is observed for Lake Tana catchment for mean volumes and high/low flows. The hydrological models for Lake Tana catchment, however, performed better in simulating the hydrological regimes than for Nyando, which obviously also induces a difference in the reliability of the extreme future projections for both catchments. The unclear impact result for Lake Tana catchment implies that the GCM uncertainty is more important for explaining the unclear trend than the hydrological models uncertainty. Nevertheless, to have a better understanding of future impact, hydrological models need to be verified for their credibility of simulating extreme flows.

  2. Sensitivity of extreme precipitation to temperature: the variability of scaling factors from a regional to local perspective

    Science.gov (United States)

    Schroeer, K.; Kirchengast, G.

    2018-06-01

    Potential increases in extreme rainfall induced hazards in a warming climate have motivated studies to link precipitation intensities to temperature. Increases exceeding the Clausius-Clapeyron (CC) rate of 6-7%/°C-1 are seen in short-duration, convective, high-percentile rainfall at mid latitudes, but the rates of change cease or revert at regionally variable threshold temperatures due to moisture limitations. It is unclear, however, what these findings mean in term of the actual risk of extreme precipitation on a regional to local scale. When conditioning precipitation intensities on local temperatures, key influences on the scaling relationship such as from the annual cycle and regional weather patterns need better understanding. Here we analyze these influences, using sub-hourly to daily precipitation data from a dense network of 189 stations in south-eastern Austria. We find that the temperature sensitivities in the mountainous western region are lower than in the eastern lowlands. This is due to the different weather patterns that cause extreme precipitation in these regions. Sub-hourly and hourly intensities intensify at super-CC and CC-rates, respectively, up to temperatures of about 17 °C. However, we also find that, because of the regional and seasonal variability of the precipitation intensities, a smaller scaling factor can imply a larger absolute change in intensity. Our insights underline that temperature precipitation scaling requires careful interpretation of the intent and setting of the study. When this is considered, conditional scaling factors can help to better understand which influences control the intensification of rainfall with temperature on a regional scale.

  3. Complex regional pain syndrome 1 – the Swiss cohort study

    Directory of Open Access Journals (Sweden)

    Perez Roberto SGM

    2008-06-01

    Full Text Available Abstract Background Little is known about the course of Complex Regional Pain Syndrome 1 and potential factors influencing the course of this disorder over time. The goal of this study is a to set up a database with patients suffering from suspected CRPS 1 in an initial stadium, b to perform investigations on epidemiology, diagnosis, prognosis, and socioeconomics within the database and c to develop a prognostic risk assessment tool for patients with CRPS 1 taking into account symptomatology and specific therapies. Methods/design Prospective cohort study. Patients suffering from a painful swelling of the hand or foot which appeared within 8 weeks after a trauma or a surgery and which cannot be explained by conditions that would otherwise account for the degree of pain and dysfunction will be included. In accordance with the recommendations of International Classification of Functioning, Disability and Health (ICF model, standardised and validated questionnaires will be used. Patients will be monitored over a period of 2 years at 6 scheduled visits (0 and 6 weeks, 3, 6, 12, and 24 months. Each visit involves a physical examination, registration of therapeutic interventions, and completion of the various study questionnaires. Outcomes involve changes in health status, quality of life and costs/utility. Discussion This paper describes the rationale and design of patients with CRPS 1. Ideally, potential risk factors may be identified at an early stage in order to initiate an early and adequate treatment in patients with increased risk for delayed recovery. Trial registration Not applicable

  4. Activation of cutaneous immune responses in complex regional pain syndrome

    Science.gov (United States)

    Birklein, Frank; Drummond, Peter D.; Li, Wenwu; Schlereth, Tanja; Albrecht, Nahid; Finch, Philip M.; Dawson, Linda F.; Clark, J. David; Kingery, Wade S.

    2014-01-01

    The pathogenesis of complex regional pain syndrome (CRPS) is unresolved, but TNF-α and IL-6 are elevated in experimental skin blister fluid from CRPS affected limbs, as is tryptase, a marker for mast cells. In the rat fracture model of CRPS exaggerated sensory and sympathetic neural signaling stimulate keratinocyte and mast cell proliferation, causing the local production of high levels of inflammatory cytokines leading to pain behavior. The current investigation used CRPS patient skin biopsies to determine whether keratinocyte and mast cell proliferation occur in CRPS skin and to identify the cellular source of the up-regulated TNF-α, IL-6, and tryptase observed in CRPS experimental skin blister fluid. Skin biopsies were collected from the affected skin and the contralateral mirror site in 55 CRPS patients and the biopsy sections were immunostained for keratinocyte, cell proliferation, mast cell markers, TNF-α, and IL-6. In early CRPS keratinocytes were activated in the affected skin, resulting in proliferation, epidermal thickening, and up-regulated TNF-α and IL-6 expression. In chronic CRPS there was reduced keratinocyte proliferation with epidermal thinning in the affected skin. Acute CRPS patients also had increased mast cell accumulation in the affected skin, but there was no increase in mast cell numbers in chronic CRPS. PMID:24462502

  5. Genome-Wide Expression Profiling of Complex Regional Pain Syndrome

    Science.gov (United States)

    Jin, Eun-Heui; Zhang, Enji; Ko, Youngkwon; Sim, Woo Seog; Moon, Dong Eon; Yoon, Keon Jung; Hong, Jang Hee; Lee, Won Hyung

    2013-01-01

    Complex regional pain syndrome (CRPS) is a chronic, progressive, and devastating pain syndrome characterized by spontaneous pain, hyperalgesia, allodynia, altered skin temperature, and motor dysfunction. Although previous gene expression profiling studies have been conducted in animal pain models, there genome-wide expression profiling in the whole blood of CRPS patients has not been reported yet. Here, we successfully identified certain pain-related genes through genome-wide expression profiling in the blood from CRPS patients. We found that 80 genes were differentially expressed between 4 CRPS patients (2 CRPS I and 2 CRPS II) and 5 controls (cut-off value: 1.5-fold change and pCRPS patients and 18 controls by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). We focused on the MMP9 gene that, by qRT-PCR, showed a statistically significant difference in expression in CRPS patients compared to controls with the highest relative fold change (4.0±1.23 times and p = 1.4×10−4). The up-regulation of MMP9 gene in the blood may be related to the pain progression in CRPS patients. Our findings, which offer a valuable contribution to the understanding of the differential gene expression in CRPS may help in the understanding of the pathophysiology of CRPS pain progression. PMID:24244504

  6. Complex regional pain syndromes (CRPS type 1 validating case histories

    Directory of Open Access Journals (Sweden)

    P. Berger

    2003-01-01

    Full Text Available The treatment of patients with complex regional pain syndrome (CRPS type 1 is challenging and unpredictable as the condition presents with vascular and neuropathic symptoms after nil or even minor injury to a peripheral nerve. The condition is one of a pain and motor dysfunction. The pathophysiology is not well understood and the relief of symptoms may change from being sympathetically mediated to sympathetically independent during  the course of the disease. At any stage physiotherapy has been advocated as the corner stone and most important aspect of treatment in the rehabilitation of these individuals but unfortunately it has been difficult to execute when pain is exacerbated due to allodynia (unbearable to touch or move and hyperalgesia. Best results have been obtained if the patients are recognised and treated in the early or acute phase and it has been found that through careful assessment and analysis these patients can be recognised by previous events that have occurred in their initial case history. The treatment in the acute stage with physiotherapy modalities such as electrical stimulation and acupuncture will produce an early cessation of the symptoms and prevention of the disease developing into the fully blown CRPS type 1 with irreversible and possibly atrophic consequences. Case histories have been presented that illustrate these important aspects and demonstrate  the value of early and the appropriate physiotherapy that may be more successful than other pharmacological and physical interventions in this disease.

  7. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1

    Directory of Open Access Journals (Sweden)

    S.H. Botha

    2004-06-01

    Full Text Available Complex regional pain syndrome (CPRS, type 1 is a pain disorder that develops unpredictably and can follow a minor injury. A 12-year-old boy presented with severe pain in the feet and could not walk or stand weight bearing. Normal X-rays showed osteopenic changes and radiolucent lines, which appeared to be stress fractures. Three-phase bone scintigraphy showed no uptake in the left lower leg on the blood pool phase or on the immediate or delayed images. This indicated typical CPRS type 1 in children. The uptake in the right foot was increased and the stress fracture and other illness could not be differentiated. Computed tomography was done to exclude stress fractures. Only osteopenic changes in both calcaneus bones were found and there was no evidence of cortical stress fractures. Magnetic resonance images revealed oedema in the calcaneus and talus bones of both feet. The patient received epidural narcotic infusion with sympathetic blockage for 1 week combined with extensive physiotherapy. The blood pool phase of the bone scan became normal within 2 weeks, and increased uptake in both feet was noticed. The patient was followed up with MRI every 3 months and the bone marrow oedema disappeared after 6 months.

  8. On the importance of observational data properties when assessing regional climate model performance of extreme precipitation

    DEFF Research Database (Denmark)

    Sunyer Pinya, Maria Antonia; Sørup, Hjalte Jomo Danielsen; Christensen, Ole Bøssing

    2013-01-01

    datasets, the RCMs are ranked according to their performance using two different metrics. These are based on the error in representing the indices and the spatial correlation. In comparison to the mean, extreme precipitation indices are highly dependent on the spatial resolution of the observations...

  9. Characteristics of extreme precipitation in the Vosges Mountains region (north-eastern France)

    Czech Academy of Sciences Publication Activity Database

    Minářová, Jana; Müller, Miloslav; Clappier, A.; Kašpar, Marek

    2017-01-01

    Roč. 37, č. 13 (2017), s. 4529-4542 ISSN 0899-8418 Institutional support: RVO:68378289 Keywords : Vosges Mountains * extreme precipitation * heavy rainfall * WEI * synoptic conditions * precipitation * Grosswetterlagen * trend analysis Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 3.760, year: 2016 http://onlinelibrary.wiley.com/doi/10.1002/joc.5102/abstract

  10. Analysis of long-term changes in extreme climatic indices: a case study of the Mediterranean climate, Marmara Region, Turkey

    Science.gov (United States)

    Abbasnia, Mohsen; Toros, Hüseyin

    2018-05-01

    This study aimed to analyze extreme temperature and precipitation indices at seven stations in the Marmara Region of Turkey for the period 1961-2016. The trend of temperature indices showed that the warm-spell duration and the numbers of summer days, tropical nights, warm nights, and warm days have increased, while the cold-spell duration and number of ice days, cool nights, and cool days have decreased across the Marmara Region. Additionally, the diurnal temperature range has slightly increased at most of the stations. A majority of stations have shown significant warming trends for warm days and warm nights throughout the study area, whereas warm extremes and night-time based temperature indices have shown stronger trends compared to cold extremes and day-time indices. The analysis of precipitation indices has mostly shown increasing trends in consecutive dry days and increasing trends in annual rainfall, rainfall intensity for inland and urban stations, especially for stations in Sariyer and Edirne, which are affected by a fast rate of urbanization. Overall, a large proportion of study stations have experienced an increase in annual precipitation and heavy precipitation events, although there was a low percentage of results that was significant. Therefore, it is expected that the rainfall events will tend to become shorter and more intense, the occurrence of temperature extremes will become more pronounced in favor of hotter events, and there will be an increase in the atmospheric moisture content over the Marmara Region. This provides regional evidence for the importance of ongoing research on climate change.

  11. Bunched black (and grouped grey) swans: Dissipative and non-dissipative models of correlated extreme fluctuations in complex geosystems

    Science.gov (United States)

    Watkins, N. W.

    2013-01-01

    I review the hierarchy of approaches to complex systems, focusing particularly on stochastic equations. I discuss how the main models advocated by the late Benoit Mandelbrot fit into this classification, and how they continue to contribute to cross-disciplinary approaches to the increasingly important problems of correlated extreme events and unresolved scales. The ideas have broad importance, with applications ranging across science areas as diverse as the heavy tailed distributions of intense rainfall in hydrology, after which Mandelbrot named the "Noah effect"; the problem of correlated runs of dry summers in climate, after which the "Joseph effect" was named; and the intermittent, bursty, volatility seen in finance and fluid turbulence.

  12. Quantifying enhancement in aerosol radiative forcing during 'extreme aerosol days' in summer at Delhi National Capital Region, India.

    Science.gov (United States)

    Kumar, Sumant; Dey, Sagnik; Srivastava, Arun

    2016-04-15

    Changes in aerosol characteristics (spectral aerosol optical depth, AOD and composition) are examined during the transition from 'relatively clean' to 'extreme' aerosol days in the summer of 2012 at Delhi National Capital Region (NCR), India. AOD smaller than 0.54 (i.e. 12-year mean AOD-1σ) represents 'relatively clean' days in Delhi during the summer. 'Extreme' days are defined by the condition when AOD0.5 exceeds 12-year mean AOD+1 standard deviation (σ). Mean (±1σ) AOD increases to 1.2±0.12 along with a decrease of Angstrom Exponent from 0.54±0.09 to 0.22±0.12 during the 'extreme' days. Aerosol composition is inferred by fixing the number concentrations of various individual species through iterative tweaking when simulated (following Mie theory) AOD spectrum matches with the measured one. Contribution of coarse mode dust to aerosol mass increased from 76.8% (relatively clean) to 96.8% (extreme events), while the corresponding contributions to AOD0.5 increased from 35.0% to 70.8%. Spectrally increasing single scattering albedo (SSA) and CALIPSO aerosol sub-type information support the dominant presence of dust during the 'extreme' aerosol days. Aerosol direct radiative forcing (ADRF) at the top-of-the-atmosphere increases from 21.2Wm(-2) (relatively clean) to 56.6Wm(-2) (extreme), while the corresponding change in surface ADRF is from -99.5Wm(-2) to -153.5Wm(-2). Coarse mode dust contributes 60.3% of the observed surface ADRF during the 'extreme' days. On the contrary, 0.4% mass fraction of black carbon (BC) translates into 13.1% contribution to AOD0.5 and 33.5% to surface ADRF during the 'extreme' days. The atmospheric heating rate increased by 75.1% from 1.7K/day to 2.96K/day during the 'extreme' days. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Mean and extreme temperatures in a warming climate: EURO CORDEX and WRF regional climate high-resolution projections for Portugal

    Science.gov (United States)

    Cardoso, Rita M.; Soares, Pedro M. M.; Lima, Daniela C. A.; Miranda, Pedro M. A.

    2018-02-01

    Large temperature spatio-temporal gradients are a common feature of Mediterranean climates. The Portuguese complex topography and coastlines enhances such features, and in a small region large temperature gradients with high interannual variability is detected. In this study, the EURO-CORDEX high-resolution regional climate simulations (0.11° and 0.44° resolutions) are used to investigate the maximum and minimum temperature projections across the twenty-first century according to RCP4.5 and RCP8.5. An additional WRF simulation with even higher resolution (9 km) for RCP8.5 scenario is also examined. All simulations for the historical period (1971-2000) are evaluated against the available station observations and the EURO-CORDEX model results are ranked in order to build multi-model ensembles. In present climate models are able to reproduce the main topography/coast related temperature gradients. Although there are discernible differences between models, most present a cold bias. The multi-model ensembles improve the overall representation of the temperature. The ensembles project a significant increase of the maximum and minimum temperatures in all seasons and scenarios. Maximum increments of 8 °C in summer and autumn and between 2 and 4 °C in winter and spring are projected in RCP8.5. The temperature distributions for all models show a significant increase in the upper tails of the PDFs. In RCP8.5 more than half of the extended summer (MJJAS) has maximum temperatures exceeding the historical 90th percentile and, on average, 60 tropical nights are projected for the end of the century, whilst there are only 7 tropical nights in the historical period. Conversely, the number of cold days almost disappears. The yearly average number of heat waves increases by seven to ninefold by 2100 and the most frequent length rises from 5 to 22 days throughout the twenty-first century. 5% of the longest events will last for more than one month. The amplitude is overwhelming

  14. Estimation of regional intensity-duration-frequency curves for extreme precipitation

    DEFF Research Database (Denmark)

    Madsen, Henrik; Mikkelsen, Peter Steen; Rosbjerg, Dan

    1998-01-01

    of regional homogeneity and identification of a proper regional distribution L-moment analysis is applied. To analyse the regional variability in more detail, a generalised least squares regression analysis is carried out that relates the PDS model parameters to climatic and physiographic characteristics...

  15. Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity

    DEFF Research Database (Denmark)

    Sandvig, Kirsten; Torgersen, Maria Lyngaas; Raa, Hilde Andersen

    2008-01-01

    Today it is generally accepted that there are several endocytic mechanisms, both the clathrin-dependent one and mechanisms which operate without clathrin and with different requirements when it comes to dynamin, small GTP-binding proteins of the Rho family and specific lipids. It should be noted ...... to give an overview of the complexity of the mechanisms and their regulation....

  16. Complex magnetic susceptibility setup for spectroscopy in the extremely low-frequency range

    NARCIS (Netherlands)

    Kuipers, B.W.M.; Bakelaar, I.A.; Klokkenburg, M.; Erne, B.H.

    2008-01-01

    A sensitive balanced differential transformer was built to measure complex initial parallel magnetic susceptibility spectra in the 0.01–1000 Hz range. The alternating magnetic field can be chosen sufficiently weak that the magnetic structure of the samples is only slightly perturbed and the low

  17. Estrogens and the risk of complex regional pain syndrome (CRPS).

    Science.gov (United States)

    de Mos, M; Huygen, F J P M; Stricker, B H Ch; Dieleman, J P; Sturkenboom, M C J M

    2009-01-01

    Since complex regional pain syndrome (CRPS) shows a clear female predominance, we investigated the association between the cumulative as well as current exposure to estrogens, and CRPS. A population-based case-control study was conducted in the Integrated Primary Care Information (IPCI) project in the Netherlands. Cases were identified from electronic records (1996-2005) and included if they were confirmed during a visit (using International Association for the Study of Pain Criteria), or had been diagnosed by a specialist. Controls were matched to cases on gender, age, calendar time, and injury. Measures of cumulative endogenous estrogen exposure were obtained by questionnaire and included age of menarche and menopause, menstrual life, and cumulative months of pregnancy and breast-feeding. Current estrogen exposure at CRPS onset was retrieved from the electronic medical records and determined by current pregnancy or by the use of oral contraceptive (OC) drugs or hormonal replacement therapy (HRT). Hundred and forty-three female cases (1493 controls) were included in analyses on drug use and pregnancies, while cumulative endogenous estrogen exposure was studied in 53 cases (58 controls) for whom questionnaire data were available. There was no association between CRPS and either cumulative endogenous estrogen exposure, OC, or HRT use. CRPS onset was increased during the first 6 months after pregnancy (OR: 5.6, 95%CI: 1.0-32.4), although based on small numbers. We did not find an association between CRPS onset and cumulative endogenous estrogen exposure or current OC or HRT use, but more powered studies are needed to exclude potential minor associations.

  18. Sensitization of the Nociceptive System in Complex Regional Pain Syndrome

    Science.gov (United States)

    Diedrichs, Carolina; Baron, Ralf; Gierthmühlen, Janne

    2016-01-01

    Background Complex regional pain syndrome type I (CRPS-I) is characterized by sensory, motor and autonomic abnormalities without electrophysiological evidence of a nerve lesion. Objective Aims were to investigate how sensory, autonomic and motor function change in the course of the disease. Methods 19 CRPS-I patients (17 with acute, 2 with chronic CRPS, mean duration of disease 5.7±8.3, range 1–33 months) were examined with questionnaires (LANSS, NPS, MPI, Quick DASH, multiple choice list of descriptors for sensory, motor, autonomic symptoms), motor and autonomic tests as well as quantitative sensory testing according to the German Research Network on Neuropathic Pain at two visits (baseline and 36±10.6, range 16–53 months later). Results CRPS-I patients had an improvement of sudomotor and vasomotor function, but still a great impairment of sensory and motor function upon follow-up. Although pain and mechanical detection improved upon follow-up, thermal and mechanical pain sensitivity increased, including the contralateral side. Increase in mechanical pain sensitivity and loss of mechanical detection were associated with presence of ongoing pain. Conclusions The results demonstrate that patients with CRPS-I show a sensitization of the nociceptive system in the course of the disease, for which ongoing pain seems to be the most important trigger. They further suggest that measured loss of function in CRPS-I is due to pain-induced hypoesthesia rather than a minimal nerve lesion. In conclusion, this article gives evidence for a pronociceptive pain modulation profile developing in the course of CRPS and thus helps to assess underlying mechanisms of CRPS that contribute to the maintenance of patients’ pain and disability. PMID:27149519

  19. Sensitization of the Nociceptive System in Complex Regional Pain Syndrome.

    Directory of Open Access Journals (Sweden)

    Maren Reimer

    Full Text Available Complex regional pain syndrome type I (CRPS-I is characterized by sensory, motor and autonomic abnormalities without electrophysiological evidence of a nerve lesion.Aims were to investigate how sensory, autonomic and motor function change in the course of the disease.19 CRPS-I patients (17 with acute, 2 with chronic CRPS, mean duration of disease 5.7±8.3, range 1-33 months were examined with questionnaires (LANSS, NPS, MPI, Quick DASH, multiple choice list of descriptors for sensory, motor, autonomic symptoms, motor and autonomic tests as well as quantitative sensory testing according to the German Research Network on Neuropathic Pain at two visits (baseline and 36±10.6, range 16-53 months later.CRPS-I patients had an improvement of sudomotor and vasomotor function, but still a great impairment of sensory and motor function upon follow-up. Although pain and mechanical detection improved upon follow-up, thermal and mechanical pain sensitivity increased, including the contralateral side. Increase in mechanical pain sensitivity and loss of mechanical detection were associated with presence of ongoing pain.The results demonstrate that patients with CRPS-I show a sensitization of the nociceptive system in the course of the disease, for which ongoing pain seems to be the most important trigger. They further suggest that measured loss of function in CRPS-I is due to pain-induced hypoesthesia rather than a minimal nerve lesion. In conclusion, this article gives evidence for a pronociceptive pain modulation profile developing in the course of CRPS and thus helps to assess underlying mechanisms of CRPS that contribute to the maintenance of patients' pain and disability.

  20. Extremely Severe Space Weather and Geomagnetically Induced Currents in Regions with Locally Heterogeneous Ground Resistivity

    Science.gov (United States)

    Fujita, Shigeru; Kataoka, Ryuho; Pulkkinen, Antti; Watari, Shinichi

    2016-01-01

    Large geomagnetically induced currents (GICs) triggered by extreme space weather events are now regarded as one of the serious natural threats to the modern electrified society. The risk is described in detail in High-Impact, Low-Frequency Event Risk, A Jointly-Commissioned Summary Report of the North American Electric Reliability Corporation and the US Department of Energy's November 2009 Workshop, June 2010. For example, the March 13-14,1989 storm caused a large-scale blackout affecting about 6 million people in Quebec, Canada, and resulting in substantial economic losses in Canada and the USA (Bolduc 2002). Therefore, European and North American nations have invested in GIC research such as the Solar Shield project in the USA (Pulkkinen et al. 2009, 2015a). In 2015, the Japanese government (Ministry of Economy, Trade and Industry, METI) acknowledged the importance of GIC research in Japan. After reviewing the serious damages caused by the 2011 Tohoku-Oki earthquake, METI recognized the potential risk to the electric power grid posed by extreme space weather. During extreme events, GICs can be concerning even in mid- and low-latitude countries and have become a global issue.

  1. The role of land-climate interactions for the regional amplification of temperature extremes in climate projections

    Science.gov (United States)

    Seneviratne, S. I.; Vogel, M.; Zscheischler, J.; Schwingshackl, C.; Davin, E.; Gudmundsson, L.; Guillod, B.; Hauser, M.; Hirsch, A.; Hirschi, M.; Humphrey, V.; Thiery, W.

    2017-12-01

    Regional hot extremes are projected to increase more strongly than the global mean temperature, with substantially larger changes than 2°C even if global warming is limited to this level (Seneviratne et al. 2016). This presentation will highlight the processes underlying this behavior, which is strongly related to land-climate feedbacks (Vogel et al. 2017). The identified feedbacks are also affecting the occurrence probability of compound drought and heat events (Zscheischler and Seneviratne 2017), with high relevance for impacts on forest fire and agriculture production. Moreover, the responsible land processes strongly contribute to the inter-model spread in the projections, and can thus be used to derive observations-based constraints to reduce the uncertainty of projected changes in climate extremes. Finally, we will also discuss the role of soil moisture effects on carbon uptake and their relevance for projections, as well as the role of land use changes in affecting the identified feedbacks and projected changes in climate extremes. References: Seneviratne, S.I., M. Donat, A.J. Pitman, R. Knutti, and R.L. Wilby, 2016: Allowable CO2 emissions based on regional and impact-related climate targets. Nature, 529, 477-483, doi:10.1038/nature16542. Vogel, M.M., R. Orth, F. Cheruy, S. Hagemann, R. Lorenz, B.J.J.M. Hurk, and S.I. Seneviratne, 2017: Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks. Geophysical Research Letters, 44(3), 1511-1519, doi:10.1002/2016GL071235. Zscheischler, J., and S.I. Seneviratne, 2017: Dependence of drivers affects risks associated with compound events. Science Advances, 3(6), doi: 10.1126/sciadv.1700263

  2. On Wind Forces in the Forest-Edge Region During Extreme-Gust Passages and Their Implications for Damage Patterns

    Science.gov (United States)

    Gromke, Christof; Ruck, Bodo

    2018-03-01

    A damage pattern that is occasionally found after a period of strong winds shows an area of damaged trees inside a forest stand behind an intact stripe of trees directly at the windward edge. In an effort to understand the mechanism leading to this damage pattern, wind loading in the forest-edge region during passages of extreme gusts with different characteristics are investigated using a scaled forest model in the wind tunnel. The interaction of a transient extreme gust with the stationary atmospheric boundary layer (ABL) as a background flow at the forest edge leads to the formation of a vortex at the top of the canopy. This vortex intensifies when travelling downstream and subsequently deflects high-momentum air from above the canopy downwards resulting in increased wind loading on the tree crowns. Under such conditions, the decrease in wind loading in the streamwise direction can be relatively weak compared to stationary ABL approach flows. The resistance of trees with streamwise distance from the forest edge, however, is the result of adaptive growth to wind loading under stationary flow conditions and shows a rapid decline within two to three tree heights behind the windward edge. For some of the extreme gusts realized, an exceedance of the wind loading over the resistance of the trees is found at approximately three tree heights behind the forest edge, suggesting that the damage pattern described above can be caused by the interaction of a transient extreme gust with the stationary ABL flow.

  3. Lower extremity fatigue increases complexity of postural control during a single-legged stance

    Directory of Open Access Journals (Sweden)

    Bailey Jerry J

    2011-08-01

    Full Text Available Abstract Background Non-linear approaches to assessment of postural control can provide insight that compliment linear approaches. Control entropy (CE is a recently developed statistical tool from non-linear dynamical systems used to assess the complexity of non-stationary signals. We have previously used CE of high resolution accelerometry in running to show decreased complexity with exhaustive exercise. The purpose of this study was to determine if complexity of postural control decreases following fatiguing exercise using CE. Methods Ten subjects (5 M/5 F; 25 ± 3 yr; 169.4 ± 11.7 cm; 79.0 ± 16.9 kg consented to participation approved by Western Oregon University IRB and completed two trials separated by 2-7 days. Trials consisted of two single-legged balance tests separated by two Wingate anaerobic tests (WAnT; PreFat/PostFat, or rest period (PreRest/PostRest. Balance tests consisted of a series of five single-legged stances, separated by 30 s rest, performed while standing on the dominant leg for 15-s with the participant crossing the arms over the chest and flexing the non-dominant knee to 90 degrees. High resolution accelerometers (HRA were fixed superficial to L3/L4 at the approximate center of mass (COM. Triaxial signals from the HRA were streamed in real time at 625 Hz. COM accelerations were recorded in g's for vertical (VT, medial/lateral (ML, and anterior/posterior (AP axes. A newly developed statistic (R-test was applied to group response shapes generated by Karhunen Loeve (KL transform modes resulting from Control Entropy (CE analysis. Results R-tests showed a significant mean vector difference (p p p p Conclusions These data indicate that fatiguing exercise eliminates the differential complexity response between axes, but increases complexity in all axes compared to the non-fatigued condition. This has implications with regard to the effects of fatigue on strategies of the control system to maintain postural control.

  4. MicroRNA modulation in complex regional pain syndrome

    Directory of Open Access Journals (Sweden)

    Orlova Irina A

    2011-11-01

    Full Text Available Abstract Background Aberrant expression of small noncoding RNAs called microRNAs (miRNAs is a common feature of several human diseases. The objective of the study was to identify miRNA modulation in patients with complex regional pain syndrome (CRPS a chronic pain condition resulting from dysfunction in the central and/or peripheral nervous systems. Due to a multitude of inciting pathologies, symptoms and treatment conditions, the CRPS patient population is very heterogeneous. Our goal was to identify differentially expressed miRNAs in blood and explore their utility in patient stratification. Methods We profiled miRNAs in whole blood from 41 patients with CRPS and 20 controls using TaqMan low density array cards. Since neurogenic inflammation is known to play a significant role in CRPS we measured inflammatory markers including chemokines, cytokines, and their soluble receptors in blood from the same individuals. Correlation analyses were performed for miRNAs, inflammatory markers and other parameters including disease symptoms, medication, and comorbid conditions. Results Three different groups emerged from miRNA profiling. One group was comprised of 60% of CRPS patients and contained no control subjects. miRNA profiles from the remaining patients were interspersed among control samples in the other two groups. We identified differential expression of 18 miRNAs in CRPS patients. Analysis of inflammatory markers showed that vascular endothelial growth factor (VEGF, interleukin1 receptor antagonist (IL1Ra and monocyte chemotactic protein-1 (MCP1 were significantly elevated in CRPS patients. VEGF and IL1Ra showed significant correlation with the patients reported pain levels. Analysis of the patients who were clustered according to their miRNA profile revealed correlations that were not significant in the total patient population. Correlation analysis of miRNAs detected in blood with additional parameters identified miRNAs associated with

  5. Future extreme events in European climate: An exploration of regional climate model projections

    DEFF Research Database (Denmark)

    Beniston, M.; Stephenson, D.B.; Christensen, O.B.

    2007-01-01

    -90) and future (2071-2 100) climate on the basis of regional climate model simulations produced by the PRUDENCE project. A summary of the main results follows. Heat waves - Regional surface warming causes the frequency, intensity and duration of heat waves to increase over Europe. By the end of the twenty first...

  6. The impact of CO2 fertilization and historical land use/land cover change on regional climate extremes

    Science.gov (United States)

    Findell, Kirsten; Berg, Alexis; Gentine, Pierre; Krasting, John; Lintner, Benjamin; Malyshev, Sergey; Santanello, Joseph; Shevliakova, Elena

    2017-04-01

    Recent research highlights the role of land surface processes in heat waves, droughts, and other extreme events. Here we use an earth system model (ESM) from the Geophysical Fluid Dynamics Laboratory (GFDL) to investigate the regional impacts of historical anthropogenic land use/land cover change (LULCC) and the vegetative response to changes in atmospheric CO2 on combined extremes of temperature and humidity. A bivariate assessment allows us to consider aridity and moist enthalpy extremes, quantities central to human experience of near-surface climate conditions. We show that according to this model, conversion of forests to cropland has contributed to much of the upper central US and central Europe experiencing extreme hot, dry summers every 2-3 years instead of every 10 years. In the tropics, historical patterns of wood harvesting, shifting cultivation and regrowth of secondary vegetation have enhanced near surface moist enthalpy, leading to extensive increases in the occurrence of humid conditions throughout the tropics year round. These critical land use processes and practices are not included in many current generation land models, yet these results identify them as critical factors in the energy and water cycles of the midlatitudes and tropics. Current work is targeted at understanding how CO2 fertilization of plant growth impacts water use efficiency and surface flux partitioning, and how these changes influence temperature and humidity extremes. We use this modeling work to explore how remote sensing can be used to determine how different forest ecosystems in different climatological regimes are responding to enhanced CO2 and a warming world.

  7. Forecast models for urban extreme temperatures : Karachi region as a case study

    International Nuclear Information System (INIS)

    Hussain, M.A.; Abbas, A.; Ansari, M.R.K.

    2010-01-01

    The climatic signature of global warming is both local and global. The forcing by increasing greenhouse gases is global, so there is clearly a global component to the climatic signature. Moreover, the damaging impacts of global warming are manifesting themselves around the world in the form of extreme weather events like storms, tornadoes, floods and droughts, all of which have been escalating in frequency and intensity. Furthermore, it is a well-known fact that there is high degree of uncertainty surrounding projections of basic climate variables, such as temperature and precipitation. However, numerous authors have explored many of these effects individually and have begun exploring the interactions between climate change-induced impacts in different sectors of urban activities. Therefore, it is safe to say that an attempt to conduct a definitive, comprehensive analysis of all the potential impacts of climate change on the urban structure is premature at present. This communication attempts to examine the trends in maximum monthly urban temperature fluctuations. Analysis reveals increasing trends in urban temperature fluctuations showing effect of Karachi industrializations. Forecast models also suggest future scenario with respect to occurrence of extreme temperature. The analysis carried out in this work would be useful for urban planners for sustainable future development, economists and environmentalists etc. (author)

  8. Microbial arms race: Ballistic "nematocysts" in dinoflagellates represent a new extreme in organelle complexity.

    Science.gov (United States)

    Gavelis, Gregory S; Wakeman, Kevin C; Tillmann, Urban; Ripken, Christina; Mitarai, Satoshi; Herranz, Maria; Özbek, Suat; Holstein, Thomas; Keeling, Patrick J; Leander, Brian S

    2017-03-01

    We examine the origin of harpoon-like secretory organelles (nematocysts) in dinoflagellate protists. These ballistic organelles have been hypothesized to be homologous to similarly complex structures in animals (cnidarians); but we show, using structural, functional, and phylogenomic data, that nematocysts evolved independently in both lineages. We also recorded the first high-resolution videos of nematocyst discharge in dinoflagellates. Unexpectedly, our data suggest that different types of dinoflagellate nematocysts use two fundamentally different types of ballistic mechanisms: one type relies on a single pressurized capsule for propulsion, whereas the other type launches 11 to 15 projectiles from an arrangement similar to a Gatling gun. Despite their radical structural differences, these nematocysts share a single origin within dinoflagellates and both potentially use a contraction-based mechanism to generate ballistic force. The diversity of traits in dinoflagellate nematocysts demonstrates a stepwise route by which simple secretory structures diversified to yield elaborate subcellular weaponry.

  9. Objective sensory evaluation of the spread of complex regional pain syndrome.

    Science.gov (United States)

    Edinger, Lara; Schwartzman, Robert J; Ahmad, Ayesha; Erwin, Kirsten; Alexander, Guillermo M

    2013-01-01

    The spread of complex regional pain syndrome (CRPS) has been well documented. Many severe refractory long-standing patients have total body pain (TBP) that evolved from a single extremity injury. The purpose of this study was to document by objective sensory threshold testing the extent of body area involvement in 20 long-standing patients with CRPS who have TBP. A comparison of sensory threshold testing parameters between 20 long-standing refractory patients with CRPS who have TBP versus 10 healthy participants. Twenty patients with CRPS who stated that they suffered from total body pain were chosen from the Drexel University College of Medicine CRPS database. They were compared to 10 healthy participants that were age and gender matched to the patients with CRPS. The sensory parameters tested were: skin temperature; static and mechanical allodynia; thermal allodynia; mechanical hyperalgesia; after sensations following all sensory tests. The sites chosen for testing in the patients with CRPS were the most painful area in each of 8 body regions that comprised the total body area. Five patients with CRPS had signs of CRPS over 100% of their body (20%). One patient had pain over 87% and another had pain over 90% of their body area. The average percentage of body involvement was 62% (range 37% - 100%). All patients with CRPS had at least one sensory parameter abnormality in all body regions. All patients with CRPS had lower pain thresholds for static allodynia in all body areas, while 50% demonstrated a lower threshold for dynamic allodynia in all body regions compared to the healthy participants. Cold allodynia had a higher median pain rating on the Likert pain scale in all body areas versus healthy participants except for the chest, abdomen, and back. Eighty-five percent of the patients with CRPS had a significantly lower pain threshold for mechanical hyperalgesia in all body areas compared to the healthy participants. After sensations occurred after all sensory

  10. Laboratory calibration of density-dependent lines in the extreme ultraviolet spectral region

    Science.gov (United States)

    Lepson, J. K.; Beiersdorfer, P.; Gu, M. F.; Desai, P.; Bitter, M.; Roquemore, L.; Reinke, M. L.

    2012-05-01

    We have been making spectral measurements in the extreme ultraviolet (EUV) from different laboratory sources in order to investigate the electron density dependence of various astrophysically important emission lines and to test the atomic models underlying the diagnostic line ratios. The measurement are being performed at the Livermore EBIT-I electron beam ion trap, the National Spherical Torus Experiment (NSTX) at Princeton, and the Alcator C-Mod tokamak at the Massachusetts Institute of Technology, which together span an electron density of four orders of magnitude and which allow us to test the various models at high and low density limits. Here we present measurements of Fe XXII and Ar XIV, which include new data from an ultra high resolution (λ/Δλ >4000) spectrometer at the EBIT-I facility. We found good agreement between the measurements and modeling calculations for Fe XXII, but poorer agreement for Ar XIV.

  11. Extremely stable soluble high molecular mass multi-protein complex with DNase activity in human placental tissue.

    Directory of Open Access Journals (Sweden)

    Evgeniya E Burkova

    Full Text Available Human placenta is an organ which protects, feeds, and regulates the grooving of the embryo. Therefore, identification and characterization of placental components including proteins and their multi-protein complexes is an important step to understanding the placenta function. We have obtained and analyzed for the first time an extremely stable multi-protein complex (SPC, ∼ 1000 kDa from the soluble fraction of three human placentas. By gel filtration on Sepharose-4B, the SPC was well separated from other proteins of the placenta extract. Light scattering measurements and gel filtration showed that the SPC is stable in the presence of NaCl, MgCl2, acetonitrile, guanidinium chloride, and Triton in high concentrations, but dissociates efficiently in the presence of 8 M urea, 50 mM EDTA, and 0.5 M NaCl. Such a stable complex is unlikely to be a casual associate of different proteins. According to SDS-PAGE and MALDI mass spectrometry data, this complex contains many major glycosylated proteins with low and moderate molecular masses (MMs 4-14 kDa and several moderately abundant (79.3, 68.5, 52.8, and 27.2 kDa as well as minor proteins with higher MMs. The SPC treatment with dithiothreitol led to a disappearance of some protein bands and revealed proteins with lower MMs. The SPCs from three placentas efficiently hydrolyzed plasmid supercoiled DNA with comparable rates and possess at least two DNA-binding sites with different affinities for a 12-mer oligonucleotide. Progress in study of placental protein complexes can promote understanding of their biological functions.

  12. Synchronization and Causality Across Time-scales: Complex Dynamics and Extremes in El Niño/Southern Oscillation

    Science.gov (United States)

    Jajcay, N.; Kravtsov, S.; Tsonis, A.; Palus, M.

    2017-12-01

    A better understanding of dynamics in complex systems, such as the Earth's climate is one of the key challenges for contemporary science and society. A large amount of experimental data requires new mathematical and computational approaches. Natural complex systems vary on many temporal and spatial scales, often exhibiting recurring patterns and quasi-oscillatory phenomena. The statistical inference of causal interactions and synchronization between dynamical phenomena evolving on different temporal scales is of vital importance for better understanding of underlying mechanisms and a key for modeling and prediction of such systems. This study introduces and applies information theory diagnostics to phase and amplitude time series of different wavelet components of the observed data that characterizes El Niño. A suite of significant interactions between processes operating on different time scales was detected, and intermittent synchronization among different time scales has been associated with the extreme El Niño events. The mechanisms of these nonlinear interactions were further studied in conceptual low-order and state-of-the-art dynamical, as well as statistical climate models. Observed and simulated interactions exhibit substantial discrepancies, whose understanding may be the key to an improved prediction. Moreover, the statistical framework which we apply here is suitable for direct usage of inferring cross-scale interactions in nonlinear time series from complex systems such as the terrestrial magnetosphere, solar-terrestrial interactions, seismic activity or even human brain dynamics.

  13. Complex approach to power supply system in the Tomsk region

    International Nuclear Information System (INIS)

    Meshcheryakov, V.N.; Bojko, V.I.; Koshelev, F.P.; Kolpakov, G.N.; Shamanin, I.V.

    2001-01-01

    The problem of power supply of the Tomsk region is under consideration. Power sources are compared with regard to economical and ecological effectiveness. It is shown that nuclear power industry is promising for the Tomsk region due to a unique nuclear park in a town of Seversk with developed scientific, industrial, skilled personnel and construction bases. It is noted that the construction of the NPP based on two WWER-640, WWER-1000 reactors of new generation permits solving the problem of power supply of the Tomsk region [ru

  14. The role of extreme orbits in the global organization of periodic regions in parameter space for one dimensional maps

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Diogo Ricardo da, E-mail: diogo_cost@hotmail.com [Departamento de Física, UNESP – Universidade Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900, Rio Claro, SP (Brazil); Hansen, Matheus [Departamento de Física, UNESP – Universidade Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900, Rio Claro, SP (Brazil); Instituto de Física, Univ. São Paulo, Rua do Matão, Cidade Universitária, 05314-970, São Paulo – SP (Brazil); Guarise, Gustavo [Departamento de Física, UNESP – Universidade Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900, Rio Claro, SP (Brazil); Medrano-T, Rene O. [Departamento de Ciências Exatas e da Terra, UNIFESP – Universidade Federal de São Paulo, Rua São Nicolau, 210, Centro, 09913-030, Diadema, SP (Brazil); Department of Mathematics, Imperial College London, London SW7 2AZ (United Kingdom); Leonel, Edson D. [Departamento de Física, UNESP – Universidade Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900, Rio Claro, SP (Brazil); Abdus Salam International Center for Theoretical Physics, Strada Costiera 11, 34151 Trieste (Italy)

    2016-04-22

    We show that extreme orbits, trajectories that connect local maximum and minimum values of one dimensional maps, play a major role in the parameter space of dissipative systems dictating the organization for the windows of periodicity, hence producing sets of shrimp-like structures. Here we solve three fundamental problems regarding the distribution of these sets and give: (i) their precise localization in the parameter space, even for sets of very high periods; (ii) their local and global distributions along cascades; and (iii) the association of these cascades to complicate sets of periodicity. The extreme orbits are proved to be a powerful indicator to investigate the organization of windows of periodicity in parameter planes. As applications of the theory, we obtain some results for the circle map and perturbed logistic map. The formalism presented here can be extended to many other different nonlinear and dissipative systems. - Highlights: • Extreme orbits and the organization of periodic regions in parameter space. • One-dimensional dissipative mappings. • The circle map and also a time perturbed logistic map were studied.

  15. Signature of Nonstationarity in Precipitation Extremes over Urbanizing Regions in India Identified through a Multivariate Frequency Analyses

    Science.gov (United States)

    Singh, Jitendra; Hari, Vittal; Sharma, Tarul; Karmakar, Subhankar; Ghosh, Subimal

    2016-04-01

    The statistical assumption of stationarity in hydrologic extreme time/event series has been relied heavily in frequency analysis. However, due to the analytically perceivable impacts of climate change, urbanization and concomitant land use pattern, assumption of stationarity in hydrologic time series will draw erroneous results, which in turn may affect the policy and decision-making. Past studies provided sufficient evidences on changes in the characteristics of Indian monsoon precipitation extremes and further it has been attributed to climate change and urbanization, which shows need of nonstationary analysis on the Indian monsoon extremes. Therefore, a comprehensive multivariate nonstationary frequency analysis has been conducted for the entire India to identify the precipitation characteristics (intensity, duration and depth) responsible for significant nonstationarity in the Indian monsoon. We use 1o resolution of precipitation data for a period of 1901-2004, in a Generalized Additive Model for Location, Scale and Shape (GAMLSS) framework. A cluster of GAMLSS models has been developed by considering nonstationarity in different combinations of distribution parameters through different regression techniques, and the best-fit model is further applied for bivariate analysis. A population density data has been utilized to identify the urban, urbanizing and rural regions. The results showed significant differences in the stationary and nonstationary bivariate return periods for the urbanizing grids, when compared to urbanized and rural grids. A comprehensive multivariate analysis has also been conducted to identify the precipitation characteristics particularly responsible for imprinting signature of nonstationarity.

  16. The role of extreme orbits in the global organization of periodic regions in parameter space for one dimensional maps

    International Nuclear Information System (INIS)

    Costa, Diogo Ricardo da; Hansen, Matheus; Guarise, Gustavo; Medrano-T, Rene O.; Leonel, Edson D.

    2016-01-01

    We show that extreme orbits, trajectories that connect local maximum and minimum values of one dimensional maps, play a major role in the parameter space of dissipative systems dictating the organization for the windows of periodicity, hence producing sets of shrimp-like structures. Here we solve three fundamental problems regarding the distribution of these sets and give: (i) their precise localization in the parameter space, even for sets of very high periods; (ii) their local and global distributions along cascades; and (iii) the association of these cascades to complicate sets of periodicity. The extreme orbits are proved to be a powerful indicator to investigate the organization of windows of periodicity in parameter planes. As applications of the theory, we obtain some results for the circle map and perturbed logistic map. The formalism presented here can be extended to many other different nonlinear and dissipative systems. - Highlights: • Extreme orbits and the organization of periodic regions in parameter space. • One-dimensional dissipative mappings. • The circle map and also a time perturbed logistic map were studied.

  17. Conflict and complexity countering terrorism, insurgency, ethnic and regional violence

    CERN Document Server

    Bar-Yam, Yaneer; Minai, Ali

    2015-01-01

    Complexity science affords a number of novel tools for examining terrorism, particularly network analysis and NK-Boolean fitness landscapes as well as other tools drawn from non-linear dynamical systems modeling. This book follows the methodologies of complex adaptive systems research in their application to addressing the problems of terrorism, specifically terrorist networks, their structure and various methods of mapping and interdicting them as well as exploring the complex landscape of network-centric and irregular warfare. A variety of new models and approaches are presented here, including Dynamic Network Analysis, DIME/PMESII models, percolation models and emergent models of insurgency. In addition, the analysis is informed by practical experience, with analytical and policy guidance from authors who have served within the U.S. Department of Defense, the British Ministry of Defence as well as those who have served in a civilian capacity as advisors on terrorism and counter-terrorism.

  18. Spatio-temporal characteristics of the extreme precipitation by L-moment-based index-flood method in the Yangtze River Delta region, China

    Science.gov (United States)

    Yin, Yixing; Chen, Haishan; Xu, Chong-Yu; Xu, Wucheng; Chen, Changchun; Sun, Shanlei

    2016-05-01

    The regionalization methods, which "trade space for time" by pooling information from different locations in the frequency analysis, are efficient tools to enhance the reliability of extreme quantile estimates. This paper aims at improving the understanding of the regional frequency of extreme precipitation by using regionalization methods, and providing scientific background and practical assistance in formulating the regional development strategies for water resources management in one of the most developed and flood-prone regions in China, the Yangtze River Delta (YRD) region. To achieve the main goals, L-moment-based index-flood (LMIF) method, one of the most popular regionalization methods, is used in the regional frequency analysis of extreme precipitation with special attention paid to inter-site dependence and its influence on the accuracy of quantile estimates, which has not been considered by most of the studies using LMIF method. Extensive data screening of stationarity, serial dependence, and inter-site dependence was carried out first. The entire YRD region was then categorized into four homogeneous regions through cluster analysis and homogenous analysis. Based on goodness-of-fit statistic and L-moment ratio diagrams, generalized extreme-value (GEV) and generalized normal (GNO) distributions were identified as the best fitted distributions for most of the sub-regions, and estimated quantiles for each region were obtained. Monte Carlo simulation was used to evaluate the accuracy of the quantile estimates taking inter-site dependence into consideration. The results showed that the root-mean-square errors (RMSEs) were bigger and the 90 % error bounds were wider with inter-site dependence than those without inter-site dependence for both the regional growth curve and quantile curve. The spatial patterns of extreme precipitation with a return period of 100 years were finally obtained which indicated that there are two regions with highest precipitation

  19. Climate change effects on extreme flows of water supply area in Istanbul: utility of regional climate models and downscaling method.

    Science.gov (United States)

    Kara, Fatih; Yucel, Ismail

    2015-09-01

    This study investigates the climate change impact on the changes of mean and extreme flows under current and future climate conditions in the Omerli Basin of Istanbul, Turkey. The 15 regional climate model output from the EU-ENSEMBLES project and a downscaling method based on local implications from geophysical variables were used for the comparative analyses. Automated calibration algorithm is used to optimize the parameters of Hydrologiska Byråns Vattenbalansavdel-ning (HBV) model for the study catchment using observed daily temperature and precipitation. The calibrated HBV model was implemented to simulate daily flows using precipitation and temperature data from climate models with and without downscaling method for reference (1960-1990) and scenario (2071-2100) periods. Flood indices were derived from daily flows, and their changes throughout the four seasons and year were evaluated by comparing their values derived from simulations corresponding to the current and future climate. All climate models strongly underestimate precipitation while downscaling improves their underestimation feature particularly for extreme events. Depending on precipitation input from climate models with and without downscaling the HBV also significantly underestimates daily mean and extreme flows through all seasons. However, this underestimation feature is importantly improved for all seasons especially for spring and winter through the use of downscaled inputs. Changes in extreme flows from reference to future increased for the winter and spring and decreased for the fall and summer seasons. These changes were more significant with downscaling inputs. With respect to current time, higher flow magnitudes for given return periods will be experienced in the future and hence, in the planning of the Omerli reservoir, the effective storage and water use should be sustained.

  20. THE COMPLEX NORTH TRANSITION REGION OF CENTAURUS A: RADIO STRUCTURE

    Energy Technology Data Exchange (ETDEWEB)

    Neff, Susan G. [NASA' s Goddard Space Flight Center, Laboratory for Observational Cosmology, Mail Code 665, Greenbelt, MD 20771 (United States); Eilek, Jean A. [Physics Department, New Mexico Tech, Socorro, NM 87801 (United States); Owen, Frazer N., E-mail: susan.g.neff@nasa.gov [National Radio Astronomy Observatory, P.O. Box O,  Socorro, NM 87801 (United States)

    2015-04-01

    We present deep radio images of the inner ∼50 kpc of Centaurus A, taken with the Karl G. Jansky Very Large Array at 90 cm. We focus on the Transition Regions between the inner galaxy—including the active nucleus, inner radio lobes, and star-forming disk—and the outer radio lobes. We detect previously unknown extended emission around the Inner Lobes, including radio emission from the star-forming disk. We find that the radio-loud part of the North Transition Region (NTR), known as the North Middle Lobe, is significantly overpressured relative to the surrounding interstellar medium. We see no evidence for a collimated flow from the active galactic nucleus through this region. Our images show that the structure identified by Morganti et al. as a possible large-scale jet appears to be part of a narrow ridge of emission within the broader, diffuse, radio-loud region. This knotty radio ridge is coincident with other striking phenomena: compact X-ray knots, ionized gas filaments, and streams of young stars. Several short-lived phenomena in the NTR, as well as the frequent re-energization required by the Outer Lobes, suggest that energy must be flowing through both Transition Regions at the present epoch. We suggest that the energy flow is in the form of a galactic wind.

  1. The Emerging Architecture of a Regional Security Complex in the ...

    African Journals Online (AJOL)

    2015-03-03

    Mar 3, 2015 ... Council for the Development of Social Science Research in Africa, 2017 .... of International Security Studies by appropriating Regional Security .... collaborative network is also embedded across Saharan and Sahelian Africa, ... (previously located in the city of Baga in Nigeria's Borno State), fell into the.

  2. Abnormal thalamocortical activity in patients with Complex Regional Pain Syndrome (CRPS) type I.

    Science.gov (United States)

    Walton, K D; Dubois, M; Llinás, R R

    2010-07-01

    Complex Regional Pain Syndrome (CRPS) is a neuropathic disease that presents a continuing challenge in terms of pathophysiology, diagnosis, and treatment. Recent studies of neuropathic pain, in both animals and patients, have established a direct relationship between abnormal thalamic rhythmicity related to Thalamo-cortical Dysrhythmia (TCD) and the occurrence of central pain. Here, this relationship has been examined using magneto-encephalographic (MEG) imaging in CRPS Type I, characterized by the absence of nerve lesions. The study addresses spontaneous MEG activity from 13 awake, adult patients (2 men, 11 women; age 15-62), with CRPS Type I of one extremity (duration range: 3months to 10years) and from 13 control subjects. All CRPS I patients demonstrated peaks in power spectrum in the delta (CRPS Type I patients presented abnormal brain activity typical of TCD, which has both diagnostic value indicating a central origin for this ailment and a potential treatment interest involving pharmacological and electrical stimulation therapies. Copyright 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  3. Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I.

    Directory of Open Access Journals (Sweden)

    Volker Huge

    Full Text Available BACKGROUND: Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS. In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST in comparison to an age and gender matched control group. METHODS: 61 patients presenting with CRPS I of the upper extremity and 56 healthy subjects were prospectively assessed using QST. The patients' warm and cold detection thresholds (WDT; CDT, the heat and cold pain thresholds (HPT; CPT and the occurrence of paradoxical heat sensation (PHS were observed. RESULTS: In acute CRPS I, patients showed warm and cold hyperalgesia, indicated by significant changes in HPT and CPT. WDT and CDT were significantly increased as well, indicating warm and cold hypoaesthesia. In chronic CRPS, thermal hyperalgesia declined, but CDT as well as WDT further deteriorated. Solely patients with acute CRPS displayed PHS. To a minor degree, all QST changes were also present on the contralateral limb. CONCLUSIONS: We propose three pathomechanisms of CRPS I, which follow a distinct time course: Thermal hyperalgesia, observed in acute CRPS, indicates an ongoing aseptic peripheral inflammation. Thermal hypoaesthesia, as detected in acute and chronic CRPS, signals a degeneration of A-delta and C-fibres, which further deteriorates in chronic CRPS. PHS in acute CRPS I indicates that both inflammation and degeneration are present, whilst in chronic CRPS I, the pathomechanism of degeneration dominates, signalled by the absence of PHS. The contralateral changes observed strongly suggest the involvement of the central nervous system.

  4. Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I).

    Science.gov (United States)

    Huge, Volker; Lauchart, Meike; Förderreuther, Stefanie; Kaufhold, Wibke; Valet, Michael; Azad, Shahnaz Christina; Beyer, Antje; Magerl, Walter

    2008-07-23

    Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS). In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST) in comparison to an age and gender matched control group. 61 patients presenting with CRPS I of the upper extremity and 56 healthy subjects were prospectively assessed using QST. The patients' warm and cold detection thresholds (WDT; CDT), the heat and cold pain thresholds (HPT; CPT) and the occurrence of paradoxical heat sensation (PHS) were observed. In acute CRPS I, patients showed warm and cold hyperalgesia, indicated by significant changes in HPT and CPT. WDT and CDT were significantly increased as well, indicating warm and cold hypoaesthesia. In chronic CRPS, thermal hyperalgesia declined, but CDT as well as WDT further deteriorated. Solely patients with acute CRPS displayed PHS. To a minor degree, all QST changes were also present on the contralateral limb. We propose three pathomechanisms of CRPS I, which follow a distinct time course: Thermal hyperalgesia, observed in acute CRPS, indicates an ongoing aseptic peripheral inflammation. Thermal hypoaesthesia, as detected in acute and chronic CRPS, signals a degeneration of A-delta and C-fibres, which further deteriorates in chronic CRPS. PHS in acute CRPS I indicates that both inflammation and degeneration are present, whilst in chronic CRPS I, the pathomechanism of degeneration dominates, signalled by the absence of PHS. The contralateral changes observed strongly suggest the involvement of the central nervous system.

  5. A case of complex regional pain syndrome with agnosia for object orientation.

    Science.gov (United States)

    Robinson, Gail; Cohen, Helen; Goebel, Andreas

    2011-07-01

    This systematic investigation of the neurocognitive correlates of complex regional pain syndrome (CRPS) in a single case also reports agnosia for object orientation in the context of persistent CRPS. We report a patient (JW) with severe long-standing CRPS who had no difficulty identifying and naming line drawings of objects presented in 1 of 4 cardinal orientations. In contrast, he was extremely poor at reorienting these objects into the correct upright orientation and in judging whether an object was upright or not. Moreover, JW made orientation errors when copying drawings of objects, and he also showed features of mirror reversal in writing single words and reading single letters. The findings are discussed in relation to accounts of visual processing. Agnosia for object orientation is the term for impaired knowledge of an object's orientation despite good recognition and naming of the same misoriented object. This defect has previously only been reported in patients with major structural brain lesions. The neuroanatomical correlates are discussed. The patient had no structural brain lesion, raising the possibility that nonstructural reorganisation of cortical networks may be responsible for his deficits. Other patients with CRPS may have related neurocognitive defects. Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.

  6. Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Wanotayan, Rujira; Fukuchi, Mikoto; Imamichi, Shoji; Sharma, Mukesh Kumar; Matsumoto, Yoshihisa, E-mail: yoshim@nr.titech.ac.jp

    2015-02-20

    XRCC4 is one of the crucial proteins in the repair of DNA double-strand break (DSB) through non-homologous end-joining (NHEJ). As XRCC4 consists of 336 amino acids, N-terminal 200 amino acids include domains for dimerization and for association with DNA ligase IV and XLF and shown to be essential for XRCC4 function in DSB repair and V(D)J recombination. On the other hand, the role of the remaining C-terminal region of XRCC4 is not well understood. In the present study, we noticed that a stretch of ∼20 amino acids located at the extreme C-terminus of XRCC4 is highly conserved among vertebrate species. To explore its possible importance, series of mutants in this region were constructed and assessed for the functionality in terms of ability to rescue radiosensitivity of M10 cells lacking XRCC4. Among 13 mutants, M10 transfectant with N326L mutant (M10-XRCC4{sup N326L}) showed elevated radiosensitivity. N326L protein showed defective nuclear localization. N326L sequence matched the consensus sequence of nuclear export signal. Leptomycin B treatment accumulated XRCC4{sup N326L} in the nucleus but only partially rescued radiosensitivity of M10-XRCC4{sup N326L}. These results collectively indicated that the functional defects of XRCC4{sup N326L} might be partially, but not solely, due to its exclusion from nucleus by synthetic nuclear export signal. Further mutation of XRCC4 Asn326 to other amino acids, i.e., alanine, aspartic acid or glutamine did not affect the nuclear localization but still exhibited radiosensitivity. The present results indicated the importance of the extremely C-terminal region of XRCC4 and, especially, Asn326 therein. - Highlights: • Extremely C-terminal region of XRCC4 is highly conserved among vertebrate species. • XRCC4 C-terminal point mutants, R325F and N326L, are functionally deficient in terms of survival after irradiation. • N326L localizes to the cytoplasm because of synthetic nuclear export signal. • Leptomycin B restores the

  7. [Autologous transfusion of UV-irradiated blood in the complex treatment of children with dysplasia of deep veins of the extremities].

    Science.gov (United States)

    Levanovich, V V; Kupatadze, D D; Endzhibadze, Iu G; Nabokov, V V; Mazurova, E V; Ivanov, A P; Chirovich, M

    1991-02-01

    Under examination there were 12 patients aged from 5 till 14 years. An investigation of hemostatic potential of blood in the diseased extremity and peripheral blood was performed. A mosaic character of blood coagulative alterations in this category of patients was detected. Autotransfusion of UV-irradiated blood is a pathogenetically grounded and accessible method of correction of hemocoagulation and may be included in the complex treatment of patients with dysplasia of the profound veins of lower extremities.

  8. Distributions of extreme bursts above thresholds in a fractional Lévy toy model of natural complexity.

    Science.gov (United States)

    Watkins, Nicholas; Chapman, Sandra; Rosenberg, Sam; Credgington, Dan; Sanchez, Raul

    2010-05-01

    In 2 far-sighted contributions in the 1960s Mandelbrot showed the ubiquity of both non-Gaussian fluctuations and long-ranged temporal memory (the "Noah" and "Joseph" effects, respectively) in the natural and man-made worlds. Much subsequent work in complexity science has contributed to the physical underpinning of these effects, particularly in cases where complex interactions in a system cause a driven or random perturbation to be nonlinearly amplified in amplitude and/or spread out over a wide range of frequencies. In addition the modelling of catastrophes has begun to incorporate the insights which these approaches have offered into the likelihood of extreme and long-lived fluctuations. I will briefly survey how the application of the above ideas in the earth system has been a key focus and motivation of research into natural complexity at BAS [e.g. Watkins & Freeman, Science, 2008; Edwards et al, Nature, 2007]. I will then discuss in detail a standard toy model (linear fractional stable motion, LFSM) which combines the Noah and Joseph effects in a controllable way and explain how it differs from the widely used continuous time random walk. I will describe how LFSM is being used to explore the interplay of the above two effects in the distribution of bursts above thresholds. I will describe ongoing work to improve the accuracy of maximum likelihood-based estimation of burst size and waiting time distributions for LFSM first reported in [Watkins et al, PRE, 2009]; and will also touch on similar work for multifractal models [Watkins et al, PRL comment, 2009].

  9. REGIONAL FEATURES OF SPATIAL DEVELOPMENT OF THE INDUSTRIAL COMPLEX OF REGION IN CONDITIONS OF INSTABILITY

    Directory of Open Access Journals (Sweden)

    J.G. Lavrikova

    2009-09-01

    Full Text Available In clause the methodical approach to typology of spatial development of economy of the regions, considering position of region in national geoeconomic space, orientation to the global markets and character of interactions (network or integrated managing subjects in region is considered. Regional features of spatial development of regions of the Ural federal district are allocated. Directions of perfection of a level of the organization of spatial development of economy of regions in conditions of instability from positions of theories of unbalanced growth are offered.

  10. Spatio-temporal analysis of the extreme precipitation by the L-moment-based index-flood method in the Yangtze River Delta region, China

    Science.gov (United States)

    Yin, Yixing; Chen, Haishan; Xu, Chongyu; Xu, Wucheng; Chen, Changchun

    2014-05-01

    The regionalization methods which 'trade space for time' by including several at-site data records in the frequency analysis are an efficient tool to improve the reliability of extreme quantile estimates. With the main aims of improving the understanding of the regional frequency of extreme precipitation and providing scientific and practical background and assistance in formulating the regional development strategies for water resources management in one of the most developed and flood-prone regions in China, the Yangtze River Delta (YRD) region, in this paper, L-moment-based index-flood (LMIF) method, one of the popular regionalization methods, is used in the regional frequency analysis of extreme precipitation; attention was paid to inter-site dependence and its influence on the accuracy of quantile estimates, which hasn't been considered for most of the studies using LMIF method. Extensive data screening of stationarity, serial dependence and inter-site dependence was carried out first. The entire YRD region was then categorized into four homogeneous regions through cluster analysis and homogenous analysis. Based on goodness-of-fit statistic and L-moment ratio diagrams, Generalized extreme-value (GEV) and Generalized Normal (GNO) distributions were identified as the best-fit distributions for most of the sub regions. Estimated quantiles for each region were further obtained. Monte-Carlo simulation was used to evaluate the accuracy of the quantile estimates taking inter-site dependence into consideration. The results showed that the root mean square errors (RMSEs) were bigger and the 90% error bounds were wider with inter-site dependence than those with no inter-site dependence for both the regional growth curve and quantile curve. The spatial patterns of extreme precipitation with return period of 100 years were obtained which indicated that there are two regions with the highest precipitation extremes (southeastern coastal area of Zhejiang Province and the

  11. Revisiting Cholera-Climate Teleconnections in the Native Homeland: ENSO and other Extremes through the Regional Hydroclimatic Drivers

    Science.gov (United States)

    Akanda, A. S.; Jutla, A.; Huq, A.; Colwell, R. R.

    2014-12-01

    Cholera is a global disease, with significantly large outbreaks occurring since the 1990s, notably in Sub-Saharan Africa and South Asia and recently in Haiti, in the Caribbean. Critical knowledge gaps remain in the understanding of the annual recurrence in endemic areas and the nature of epidemic outbreaks, especially those that follow extreme hydroclimatic events. Teleconnections with large-scale climate phenomena affecting regional scale hydroclimatic drivers of cholera dynamics remain largely unexplained. For centuries, the Bengal delta region has been strongly influenced by the asymmetric availability of water in the rivers Ganges and the Brahmaputra. As these two major rivers are known to have strong contrasting affects on local cholera dynamics in the region, we argue that the role of El Nino-Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), or other phenomena needs to be interpreted in the context of the seasonal role of individual rivers and subsequent impact on local environmental processes, not as a teleconnection having a remote and unified effect. We present a modified hypothesis that the influences of large-scale climate phenomena such as ENSO and IOD on Bengal cholera can be explicitly identified and incorporated through regional scale hydroclimatic drivers. Here, we provide an analytical review of the literature addressing cholera and climate linkages and present hypotheses, based on recent evidence, and quantification on the role of regional scale hydroclimatic drivers of cholera. We argue that the seasonal changes in precipitation and temperature, and resulting river discharge in the GBM basin region during ENSO and IOD events have a dominant combined effect on the endemic persistence and the epidemic vulnerability to cholera outbreaks in spring and fall seasons, respectively, that is stronger than the effect of localized hydrological and socio-economic sensitivities in Bangladesh. In addition, systematic identification of underlying seasonal

  12. Risk-based consequences of extreme natural hazard processes in mountain regions - Multi-hazard analysis in Tyrol (Austria)

    Science.gov (United States)

    Huttenlau, Matthias; Stötter, Johann

    2010-05-01

    weighting within the risk concept, this has sufficient implications on the results of risk analyses. Thus, an equal and scale appropriated balance of those risk components is a fundamental key factor for effective natural hazard risk analyses. The results of such analyses inform especially decision makers in the insurance industry, the administration, and politicians on potential consequences and are the basis for appropriate risk management strategies. Thereby, results (i) on an annual or probabilistic risk comprehension have to be distinguished from (ii) scenario-based analyses. The first analyses are based on statistics of periodically or episodically occurring events whereas the latter approach is especially applied for extreme, non-linear, stochastic events. Focusing on the needs especially of insurance companies, the first approaches are appropriate for premium pricing and reinsurance strategies with an annual perspective, whereas the latter is focusing on events with extreme loss burdens under worst-case criteria to guarantee accordant reinsurance coverage. Moreover, the demand of adequate loss model approaches and methods is strengthened by the risk-based requirements of the upcoming capital requirement directive Solvency II. The present study estimates the potential elements at risk, their corresponding damage potentials and the Probable Maximum Losses (PMLs) of extreme natural hazards events in Tyrol (Austria) and considers adequatly the scale dependency and balanced application of the introduced risk components. Beside the introduced analysis an additionally portfolio analysis of a regional insurance company was executed. The geocoded insurance contracts of this portfolio analysis were the basis to estimate spatial, socio-economical and functional differentiated mean insurance values for the different risk categories of (i) buildings, (ii) contents or inventory, (iii) vehicles, and (iv) persons in the study area. The estimated mean insurance values were

  13. Numerical Research of Steam and Gas Plant Efficiency of Triple Cycle for Extreme North Regions

    Directory of Open Access Journals (Sweden)

    Galashov Nikolay

    2016-01-01

    Full Text Available The present work shows that temperature decrease of heat rejection in a cycle is necessary for energy efficiency of steam turbine plants. Minimum temperature of heat rejection at steam turbine plant work on water steam is 15°C. Steam turbine plant of triple cycle where lower cycle of steam turbine plant is organic Rankine cycle on low-boiling substance with heat rejection in air condenser, which safely allows rejecting heat at condensation temperatures below 0°C, has been offered. Mathematical model of steam and gas plant of triple cycle, which allows conducting complex researches with change of working body appearance and parameters defining thermodynamic efficiency of cycles, has been developed. On the basis of the model a program of parameters and index cycles design of steam and gas plants has been developed in a package of electron tables Excel. Numerical studies of models showed that energy efficiency of steam turbine plants of triple cycle strongly depend on low-boiling substance type in a lower cycle. Energy efficiency of steam and gas plants net 60% higher can be received for steam and gas plants on the basis of gas turbine plant NK-36ST on pentane and its condensation temperature below 0°C. It was stated that energy efficiency of steam and gas plants net linearly depends on condensation temperature of low-boiling substance type and temperature of gases leaving reco very boiler. Energy efficiency increases by 1% at 10% decrease of condensation temperature of pentane, and it increases by 0.88% at 15°C temperature decrease of gases leaving recovery boiler.

  14. High current density ion beam obtained by a transition to a highly focused state in extremely low-energy region

    Energy Technology Data Exchange (ETDEWEB)

    Hirano, Y., E-mail: y.hirano@aist.go.jp, E-mail: hirano.yoichi@phys.cst.nihon-u.ac.jp [Innovative Plasma Processing Group, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8568 (Japan); College of Science and Technologies, Nihon University, Chiyodaku, Tokyo 101-0897 (Japan); Kiyama, S.; Koguchi, H. [Innovative Plasma Processing Group, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8568 (Japan); Fujiwara, Y.; Sakakita, H. [Innovative Plasma Processing Group, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8568 (Japan); Department of Engineering Mechanics and Energy, University of Tsukuba, Ibaraki 305-8577 (Japan)

    2015-11-15

    A high current density (≈3 mA/cm{sup 2}) hydrogen ion beam source operating in an extremely low-energy region (E{sub ib} ≈ 150–200 eV) has been realized by using a transition to a highly focused state, where the beam is extracted from the ion source chamber through three concave electrodes with nominal focal lengths of ≈350 mm. The transition occurs when the beam energy exceeds a threshold value between 145 and 170 eV. Low-level hysteresis is observed in the transition when E{sub ib} is being reduced. The radial profiles of the ion beam current density and the low temperature ion current density can be obtained separately using a Faraday cup with a grid in front. The measured profiles confirm that more than a half of the extracted beam ions reaches the target plate with a good focusing profile with a full width at half maximum of ≈3 cm. Estimation of the particle balances in beam ions, the slow ions, and the electrons indicates the possibility that the secondary electron emission from the target plate and electron impact ionization of hydrogen may play roles as particle sources in this extremely low-energy beam after the compensation of beam ion space charge.

  15. To the Extremes! A Teacher Research Experience Program in the Polar Regions

    Science.gov (United States)

    Warburton, J.; Bartholow, S.

    2014-12-01

    PolarTREC-Teachers and Researchers Exploring and Collaborating, a teacher professional development program, began with the International Polar Year in 2004 and continues today in the United States. In 2007, the National Science Foundation designated PolarTREC as potentially transformative, meaning that the "research results often do not fit within established models or theories and may initially be unexpected or difficult to interpret; their transformative nature and utility might not be recognized until years later." PolarTREC brings U.S. K-12 educators and polar researchers together through an innovative teacher research experience model. Teachers spend three to six weeks in remote arctic and Antarctic field camps. Since 2007, over 100 teachers have been placed in field experiences throughout the Arctic and Antarctic and with half of them participating in field experiences in Antarctica. During their experience, teachers become research team members filling a variety of roles on the team. They also fulfil a unique role of public outreach officer, conducting live presentations about their field site and research as well as journaling, answering questions, and posting photos. Evaluation data collected over the past eight years on program participants shows that PolarTREC has clearly achieved it goals and strongly suggests programs that link teachers and researchers can have the potential to transform the nature of science education. By giving teachers the content knowledge, pedagogical tools, confidence, understanding of science in the broader society, and experiences with scientific inquiry, participating teachers are using authentic scientific research in their classrooms. Not surprisingly this has also led to increases in student interest and knowledge about the Polar Regions. In this presentation, we will highlight the best practices of teacher research experiences as well as discuss why it is vital to have teachers and researchers work together to communicate

  16. Regional Brain Biometrics at Term-Equivalent Age and Developmental Outcome in Extremely Low-Birth-Weight Infants.

    Science.gov (United States)

    Melbourne, Launice; Murnick, Jonathan; Chang, Taeun; Glass, Penny; Massaro, An N

    2015-10-01

    This study aims to evaluate individual regional brain biometrics and their association with developmental outcome in extremely low-birth-weight (ELBW) infants. This is a retrospective study evaluating term-equivalent magnetic resonance imaging (TE-MRI) from 27 ELBW infants with known developmental outcomes beyond 12 months corrected age. Regional biometric measurements were performed by a pediatric neuroradiologist blinded to outcome data. Measures included biparietal width, transcerebellar diameter (TCD), deep gray matter area (DGMA), ventricular dilatation, corpus callosum, and interhemispheric distance. The relationship between regional biometrics and Bayley-II developmental scores were evaluated with linear regression models. The study cohort had an average±standard deviation birth weight of 684±150 g, gestational age of 24.6±2 weeks and 48% males. DGMA was significantly associated with both cognitive and motor outcomes. Significant associations were also observed between TCD and corpus callosum splenium with cognitive and motor outcomes, respectively. Other biometric measures were not associated with outcome (p>0.05). DGMAbiometrics reflecting impaired deep gray matter, callosal, and cerebellar size is associated with worse early childhood cognitive and motor outcomes. DGMA may be the most robust single biometric measure to predict adverse developmental outcome in preterm survivors. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  17. Comparative Genomics of Methanopyrus sp. SNP6 and KOL6 Revealing Genomic Regions of Plasticity Implicated in Extremely Thermophilic Profiles

    Directory of Open Access Journals (Sweden)

    Zhiliang Yu

    2017-07-01

    Full Text Available Methanopyrus spp. are usually isolated from harsh niches, such as high osmotic pressure and extreme temperature. However, the molecular mechanisms for their environmental adaption are poorly understood. Archaeal species is commonly considered as primitive organism. The evolutional placement of archaea is a fundamental and intriguing scientific question. We sequenced the genomes of Methanopyrus strains SNP6 and KOL6 isolated from the Atlantic and Iceland, respectively. Comparative genomic analysis revealed genetic diversity and instability implicated in niche adaption, including a number of transporter- and integrase/transposase-related genes. Pan-genome analysis also defined the gene pool of Methanopyrus spp., in addition of ~120-Kb genomic region of plasticity impacting cognate genomic architecture. We believe that Methanopyrus genomics could facilitate efficient investigation/recognition of archaeal phylogenetic diverse patterns, as well as improve understanding of biological roles and significance of these versatile microbes.

  18. Experience from the ECORS program in regions of complex geology

    Science.gov (United States)

    Damotte, B.

    1993-04-01

    The French ECORS program was launched in 1983 by a cooperation agreement between universities and petroleum companies. Crustal surveys have tried to find explanations for the formation of geological features, such as rifts, mountains ranges or subsidence in sedimentary basins. Several seismic surveys were carried out, some across areas with complex geological structures. The seismic techniques and equipment used were those developed by petroleum geophysicists, adapted to the depth aimed at (30-50 km) and to various physical constraints encountered in the field. In France, ECORS has recorded 850 km of deep seismic lines onshore across plains and mountains, on various kinds of geological formations. Different variations of the seismic method (reflection, refraction, long-offset seismic) were used, often simultaneously. Multiple coverage profiling constitutes the essential part of this data acquisition. Vibrators and dynamite shots were employed with a spread generally 15 km long, but sometimes 100 km long. Some typical seismic examples show that obtaining crustal reflections essentialy depends on two factors: (1) the type and structure of shallow formations, and (2) the sources used. Thus, when seismic energy is strongly absorbed across the first kilometers in shallow formations, or when these formations are highly structured, standard multiple-coverage profiling is not able to provide results beyond a few seconds. In this case, it is recommended to simultaneously carry out long-offset seismic in low multiple coverage. Other more methodological examples show: how the impact on the crust of a surface fault may be evaluated according to the seismic method implemented ( VIBROSEIS 96-fold coverage or single dynamite shot); that vibrators make it possible to implement wide-angle seismic surveying with an offset 80 km long; how to implement the seismic reflection method on complex formations in high mountains. All data were processed using industrial seismic software

  19. Extreme pollution of soils by emissions of the copper-nickel industrial complex in the Kola Peninsula

    Science.gov (United States)

    Kashulina, G. M.

    2017-07-01

    The distribution of the total Ni, Cu, Co, Cd, Pb, and Zn contents was studied in the soil profiles of six catenas in the zone subjected to emissions of the copper-nickel industrial complex, which is the largest source of SO2 and heavy metals in northern Europe. The results show that, at present, the concentrations of Ni and Cu in the upper organic soil horizons in the impact zone reach extreme levels of 9000 and 6000 mg/kg, respectively. Under conditions of the long-term intense multi-element industrial emissions, the modern levels of the accumulation of polluting substances in soils greatly depend on the indirect factors, such as the degree of the technogenic degradation of soils with the loss of a significant part of soil organic matter, the reaching of threshold saturation of the topsoil with polluting metals, and competitive relationships between chemical elements. The state of the ecosystems in the impact zone varied greatly and did not always agree with the contents of the main metals-pollutants in the soils. The moisture conditions determined by the landscape position affected significantly the resistance of the ecosystems to emissions.

  20. Neuropeptides, neurogenic inflammation and complex regional pain syndrome (CRPS).

    Science.gov (United States)

    Birklein, Frank; Schmelz, Martin

    2008-06-06

    This review explains symptoms and nature of neuropeptide signaling and its importance for clinical symptoms of CRPS. Neurogenic inflammation regularly accompanies excitation of primary afferent nociceptors. It has two major components-plasma extravasation and vasodilatation. The most important mediators are the calcitonin gene-related peptide (CGRP) and substance P (SP). After peripheral trauma immune reaction (e.g. cytokines) and the attempts of the tissue to regenerate (e.g. growth factors) sensitize nociceptors and amplify neurogenic inflammation. This cascade of events has been demonstrated in rat models of CRPS. Clinical findings in these animals strongly resemble clinical findings in CRPS, and can be prevented by anti-cytokine and anti-neuropeptide treatment. In CRPS patients, there is meanwhile also plenty of evidence that neurogenic inflammation contributes to clinical presentation. Increased cytokine production was demonstrated, as well as facilitated neurogenic inflammation. Very recently even "non-inflammatory" signs of CRPS (hyperhidrosis, cold skin) have been linked to neuropeptide signaling. Surprisingly, there was even moderately increased neurogenic inflammation in unaffected body regions. This favors the possibility that CRPS patients share genetic similarities. The future search for genetic commonalities will help us to further unravel the "mystery" CRPS.

  1. Extreme dust storm over the eastern Mediterranean in September 2015: satellite, lidar, and surface observations in the Cyprus region

    Directory of Open Access Journals (Sweden)

    R.-E. Mamouri

    2016-11-01

    Full Text Available A record-breaking dust storm originating from desert regions in northern Syria and Iraq occurred over the eastern Mediterranean in September 2015. In this contribution of a series of two articles (part 1, observations; part 2, atmospheric modeling, we provide a comprehensive overview of the aerosol conditions during this extreme dust outbreak in the Cyprus region. These observations are based on satellite observations (MODIS, moderate resolution imaging spectroradiometer of aerosol optical thickness (AOT and Ångström exponent, surface particle mass (PM10 concentrations measured at four sites in Cyprus, visibility observations at three airports in southern Cyprus and corresponding conversion products (particle extinction coefficient, dust mass concentrations, EARLINET (European Aerosol Research Lidar Network lidar observations of dust vertical layering over Limassol, particle optical properties (backscatter, extinction, lidar ratio, linear depolarization ratio, and derived profiles of dust mass concentrations. Maximum 550 nm AOT exceeded values of 5.0, according to MODIS, and the mass loads were correspondingly >  10 g m−2 over Larnaca and Limassol during the passage of an extremely dense dust front on 8 September 2015. Hourly mean PM10 values were close to 8000 µg m−3 and the observed meteorological optical range (visibility was reduced to 300–750 m at Larnaca and Limassol. The visibility observations suggest peak values of the near-surface total suspended particle (TSP extinction coefficients of 6000 Mm−1 and thus TSP mass concentrations of 10 000 µg m−3. The Raman polarization lidar observations mainly indicated a double layer structure of the dust plumes (reaching to about 4 km height, pointing to at least two different dust source regions. Dust particle extinction coefficients (532 nm already exceeded 1000 Mm−1 and the mass concentrations reached 2000 µg m−3 in the elevated dust layers on

  2. Two millennia of torrential activity reconstructed from alpine lake sediments: towards regional patterns of extreme precipitation changes

    Science.gov (United States)

    Wilhelm, B.; Arnaud, F.; Giguet-Covex, C.; Sabatier, P.; Crouzet, C.; Delannoy, J. J.

    2012-04-01

    In mountain areas extreme precipitation events trigger torrential floods, characterized by a sudden and intense rise of discharge causing large human and economic losses. Their frequency and/or intensity are expected to increase in the context of global warming. However, the relationship between such events and climate changes remains difficult to assess. Long-term geological records of intense events could enable to extend documented records beyond the observational data for a better understanding of local to regional flood hazard patterns in relation to past climatic changes and hence improving predictive models. In this context, lake sediment records appear a relevant archive as they are continuous records in which the identification of high-energy sediment layers allows to reconstruct flood calendar. In addition, the flood intensity can be reconstructed from the coarse fraction of each flood layer. Frequency and intensity of past torrential floods were thus reconstructed from four high-elevation lake records of the French Alps, in the framework of Pygmalion research program. Studied sites were selected along a north-south transect over this region to investigate the flooding responses to different climatic influences (westerlies in the north and Mediterranean influences in the south). High-resolution geochemical and sedimentological analyses were undertaken for an exhaustive identification of flood layers and several dating methods (short-lived radionuclides, 14C, correlation with historic events, paleomagnetism) were combined to reduce age uncertainties as much as possible. Over the entire French Alps, the torrential-flood frequency increases at a secular timescale during the cold period of the Little Ice Age (LIA; 1300-1900 AD). This increase seems in agreement with a regional high wetness, already described in the literature, possibly related to an increase in cyclonic activity. Superimposed to this secular trend, a pluri-decadal variability appears at

  3. Hierarchical Model for the Similarity Measurement of a Complex Holed-Region Entity Scene

    Directory of Open Access Journals (Sweden)

    Zhanlong Chen

    2017-11-01

    Full Text Available Complex multi-holed-region entity scenes (i.e., sets of random region with holes are common in spatial database systems, spatial query languages, and the Geographic Information System (GIS. A multi-holed-region (region with an arbitrary number of holes is an abstraction of the real world that primarily represents geographic objects that have more than one interior boundary, such as areas that contain several lakes or lakes that contain islands. When the similarity of the two complex holed-region entity scenes is measured, the number of regions in the scenes and the number of holes in the regions are usually different between the two scenes, which complicates the matching relationships of holed-regions and holes. The aim of this research is to develop several holed-region similarity metrics and propose a hierarchical model to measure comprehensively the similarity between two complex holed-region entity scenes. The procedure first divides a complex entity scene into three layers: a complex scene, a micro-spatial-scene, and a simple entity (hole. The relationships between the adjacent layers are considered to be sets of relationships, and each level of similarity measurements is nested with the adjacent one. Next, entity matching is performed from top to bottom, while the similarity results are calculated from local to global. In addition, we utilize position graphs to describe the distribution of the holed-regions and subsequently describe the directions between the holes using a feature matrix. A case study that uses the Great Lakes in North America in 1986 and 2015 as experimental data illustrates the entire similarity measurement process between two complex holed-region entity scenes. The experimental results show that the hierarchical model accounts for the relationships of the different layers in the entire complex holed-region entity scene. The model can effectively calculate the similarity of complex holed-region entity scenes, even if the

  4. Review of complex networks application in hydroclimatic extremes with an implementation to characterize spatio-temporal drought propagation in continental USA

    Science.gov (United States)

    Konapala, Goutam; Mishra, Ashok

    2017-12-01

    The quantification of spatio-temporal hydroclimatic extreme events is a key variable in water resources planning, disaster mitigation, and preparing climate resilient society. However, quantification of these extreme events has always been a great challenge, which is further compounded by climate variability and change. Recently complex network theory was applied in earth science community to investigate spatial connections among hydrologic fluxes (e.g., rainfall and streamflow) in water cycle. However, there are limited applications of complex network theory for investigating hydroclimatic extreme events. This article attempts to provide an overview of complex networks and extreme events, event synchronization method, construction of networks, their statistical significance and the associated network evaluation metrics. For illustration purpose, we apply the complex network approach to study the spatio-temporal evolution of droughts in Continental USA (CONUS). A different drought threshold leads to a new drought event as well as different socio-economic implications. Therefore, it would be interesting to explore the role of thresholds on spatio-temporal evolution of drought through network analysis. In this study, long term (1900-2016) Palmer drought severity index (PDSI) was selected for spatio-temporal drought analysis using three network-based metrics (i.e., strength, direction and distance). The results indicate that the drought events propagate differently at different thresholds associated with initiation of drought events. The direction metrics indicated that onset of mild drought events usually propagate in a more spatially clustered and uniform approach compared to onsets of moderate droughts. The distance metric shows that the drought events propagate for longer distance in western part compared to eastern part of CONUS. We believe that the network-aided metrics utilized in this study can be an important tool in advancing our knowledge on drought

  5. Future changes in summer mean and extreme precipitation frequency in Japan by d4PDF regional climate simulations

    Science.gov (United States)

    Okada, Y.; Ishii, M.; Endo, H.; Kawase, H.; Sasaki, H.; Takayabu, I.; Watanabe, S.; Fujita, M.; Sugimoto, S.; Kawazoe, S.

    2017-12-01

    Precipitation in summer plays a vital role in sustaining life across East Asia, but the heavy rain that is often generated during this period can also cause serious damage. Developing a better understanding of the features and occurrence frequency of this heavy rain is an important element of disaster prevention. We investigated future changes in summer mean and extreme precipitation frequency in Japan using large ensemble dataset which simulated by the Non-Hydrostatic Regional Climate Model with a horizontal resolution of 20km (NHRCM20). This dataset called database for Policy Decision making for Future climate changes (d4PDF), which is intended to be utilized for the impact assessment studies and adaptation planning to global warming. The future climate experiments assume the global mean surface air temperature rise 2K and 4K from the pre-industrial period. We investigated using this dataset future changes of precipitation in summer over the Japanese archipelago based on observational locations. For mean precipitation in the present-day climate, the bias of the rainfall for each month is within 25% even considering all members (30 members). The bias at each location is found to increase by over 50% on the Pacific Ocean side of eastern part of Japan and interior locations of western part of Japan. The result in western part of Japan depends on the effect of the elevations in this model. The future changes in mean precipitation show a contrast between northern and southern Japan, with the north showing a slight increase but the south a decrease. The future changes in the frequency of extreme precipitation in the national average of Japan increase at 2K and 4K simulations compared with the present-day climate, respectively. The authors were supported by the Social Implementation Program on Climate Change Adaptation Technology (SI-CAT), the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan.

  6. Complex Regional Pain Syndrome following an Episode of Herpes Zoster: A Case Report.

    Science.gov (United States)

    Marrero, Christopher E; Mclean, Neuyen; Varnado, Keyana

    2017-01-01

    Complex regional pain syndrome (CRPS) is characterized by searing pain, hyperalgesia, edema, allodynia, and skin changes. CRPS may be difficult to diagnose and to treat given poorly understood mechanisms as well as its presentation of symptoms that may mimic common conditions such as joint stiffness in this condition as well as rheumatoid arthritis. A 71-year-old female presented to our clinic post shingles of the right upper extremity. We diagnosed her with CRPS based on the Budapest diagnostic criteria and the clinical findings of pain and decreased the range of motion along with edema, hypersensitivity, discoloration and allodynia of the right thumb and index finger. She was treated with vitamin C as well as gabapentin and physical therapy. The patient was unable to go consistently to physical therapy due to insurance limitations, and we found no clinical benefit of vitamin C in reducing her symptoms. She was lost to follow-up during her treatment but re-emerged at 21 months. At that time she reported, she was largely unchanged in regards to her right-hand symptoms but did believe the gabapentin was helpful and still continued to take 300 mg daily. This case report highlights the usefulness of the Budapest diagnostic criteria to make the diagnosis of CRPS when associated with shingles, which can cause long-term pain and mimic some findings. Prompt diagnosis is important, as recovery typically extends beyond 6 months; our patient still reported continued symptoms at 21 months post initial presentation. Our primary treatment plan was physical therapy, which she discontinued due to insurance limitations. We recommend that patients, physicians, and third-party payers work together to extend access to physical therapy. More investigation is warranted regarding symptomatic treatment, as we found limited clinical benefit of gabapentin and vitamin C.

  7. Future Precipitation Extremes in China Under Climate Change and Their Possible Mechanisms by Regional Climate Model and Earth System Model Simulations

    Science.gov (United States)

    Qin, P.; Xie, Z.

    2017-12-01

    Future precipitation extremes in China for the mid and end of 21st century were detected with six simulations using the regional climate model RegCM4 (RCM) and 17 global climate models (GCM) participated in the coupled Model Intercomparison Project Phase 5 (CMIP5). Prior to understanding the future changes in precipitation extremes, we overviewed the performance of precipitation extremes simulated by the CMIP5s and RCMs, and found both CMIP5s and RCMs could capture the temporal and spatial pattern of the historical precipitation extremes in China. In the mid-future period 2039-2058 (MF) and far-future 2079-2098 (FF), more wet precipitation extremes will occur in most area of China relative to the present period 1982-2001 (RF). We quantified the rates of the changes in precipitation extremes in China with the changes in air surface temperature (T2M) for the MF and FF period. Changes in precipitation extremes R95p were found around 5% K-1 for the MF period and 10% K-1 for the FF period, and changes in maximum 5 day precipitation (Rx5day) were detected around 4% K-1 for the MF period and 7% K-1 for the FF period, respectively. Finally, the possible physical mechanisms behind the changes in precipitation extremes in China were also discussed through the changes in specific humidity and vertical wind.

  8. Methods for deconvoluting and interpreting complex gamma- and x-ray spectral regions

    International Nuclear Information System (INIS)

    Gunnink, R.

    1983-06-01

    Germanium and silicon detectors are now widely used for the detection and measurement of x and gamma radiation. However, some analysis situations and spectral regions have heretofore been too complex to deconvolute and interpret by techniques in general use. One example is the L x-ray spectrum of an element taken with a Ge or Si detector. This paper describes some new tools and methods that were developed to analyze complex spectral regions; they are illustrated with examples

  9. An atypical case of postsurgical complex regional pain syndrome in a patient having nonhealing varicose venous ulcer treated by lumbar sympathectomy

    Directory of Open Access Journals (Sweden)

    Kailash Kothari

    2017-01-01

    Full Text Available Complex regional pain syndrome (CRPS of the lower limb is a relatively uncommon entity as compared to CRPS of the upper extremity. Literature search has revealed only 2 retrospective case series and a single case report of lower extremity CRPS type I from 1975 to 2014 on Pubmed, isolated cases of CRPS type I of lower extremity have also been reported following knee surgeries and arthroscopies. This report presents a case of lower limb CRPS type I, following surgery for varicose vein ulcer. Pain was not relieved with medications. Diagnostic lumbar sympathectomy was done and patient had tremendous relief of pain following that, proving sympathetic mediated pain of the involved limb.

  10. Complex researches on substantiation of construction and seismic stability of large dams in seismic region

    International Nuclear Information System (INIS)

    Negmatullaev, S.Kh.; Yasunov, P.A.

    2001-01-01

    This article is devoted to complex researches on substantiation of construction and seismic stability of large dams (Nurec hydroelectric power station) in seismic region. Geological, seismological, model, and engineering investigations are discussed in this work. At construction of Nurec hydroelectric power station the rich experience is accumulated. This experience can be used in analogous seismically active regions at construction similar hydroelectric power stations.

  11. Regulation of peripheral blood flow in Complex Regional Pain Syndrome: clinical implication for symptomatic relief and pain management

    Directory of Open Access Journals (Sweden)

    Coderre Terence J

    2009-09-01

    Full Text Available Abstract Background During the chronic stage of Complex Regional Pain Syndrome (CRPS, impaired microcirculation is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb. Several mechanisms may be responsible for the ischemia and pain in chronic cold CPRS. Discussion The diminished blood flow may be caused by either sympathetic dysfunction, hypersensitivity to circulating catecholamines, or endothelial dysfunction. The pain may be of neuropathic, inflammatory, nociceptive, or functional nature, or of mixed origin. Summary The origin of the pain should be the basis of the symptomatic therapy. Since the difference in temperature between both hands fluctuates over time in cold CRPS, when in doubt, the clinician should prioritize the patient's report of a persistent cold extremity over clinical tests that show no difference. Future research should focus on developing easily applied methods for clinical use to differentiate between central and peripheral blood flow regulation disorders in individual patients.

  12. Comparison of regional and seasonal changes and trends in daily surface temperature extremes over India and its subregions

    Science.gov (United States)

    Dimri, A. P.

    2018-04-01

    Regional changes in surface meteorological variables are one of the key issues affecting the Indian subcontinent especially in recent decades. These changes impact agriculture, health, water, etc., hence important to assess and investigate these changes. The Indian subcontinent is characterized by heterogeneous temperature regimes at regional and seasonal scales. The India Meteorological Department (IMD) observations are limited to recent decades as far as its spatial distribution is concerned. In particular, over Hilly region, these observations are sporadic. Due to variable topography and heterogeneous land use/land cover, it is complex to substantiate impacts. The European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-Interim (ERA-I) reanalysis not only covers a larger spatial domain but also provides a greater number of inputs than IMD. This study used ERA-I in conjunction with IMD gridded data to provide a comparative assessment of changing temperature patterns over India and its subregions at both regional and seasonal scales. Warming patterns are observed in both ERA-I and IMD data sets. Cold nights decrease during winter; warm days increase and warm spell duration increased during winter could become a cause of concern for society, agriculture, socio-economic reasons, and health. Increasing warm days over the hilly regions may affect the corresponding snow cover and thus river hydrology and glaciological dynamics. Such changes during monsoon are slower, which could be attributed to moisture availability to dampen the temperature changes. On investigation and comparison thereon, the present study provisions usages of ERA-I-based indices for various impact and adaptation studies.

  13. Investigating the influence of anthropogenic forcing on observed mean and extreme sea level pressure trends over the Mediterranean Region.

    Science.gov (United States)

    Barkhordarian, Armineh

    2012-01-01

    We investigate whether the observed mean sea level pressure (SLP) trends over the Mediterranean region in the period from 1975 to 2004 are significantly consistent with what 17 models projected as response of SLP to anthropogenic forcing (greenhouse gases and sulphate aerosols, GS). Obtained results indicate that the observed trends in mean SLP cannot be explained by natural (internal) variability. Externally forced changes are detectable in all seasons, except spring. The large-scale component (spatial mean) of the GS signal is detectable in all the 17 models in winter and in 12 of the 17 models in summer. However, the small-scale component (spatial anomalies about the spatial mean) of GS signal is only detectable in winter within 11 of the 17 models. We also show that GS signal has a detectable influence on observed decreasing (increasing) tendency in the frequencies of extremely low (high) SLP days in winter and that these changes cannot be explained by internal climate variability. While the detection of GS forcing is robust in winter and summer, there are striking inconsistencies in autumn, where analysis points to the presence of an external forcing, which is not GS forcing.

  14. Transition state region in the A-Band photodissociation of allyl iodide—A femtosecond extreme ultraviolet transient absorption study

    Energy Technology Data Exchange (ETDEWEB)

    Bhattacherjee, Aditi, E-mail: abhattacherjee@berkeley.edu, E-mail: andrewattar@berkeley.edu; Attar, Andrew R., E-mail: abhattacherjee@berkeley.edu, E-mail: andrewattar@berkeley.edu [Department of Chemistry, University of California, Berkeley, California 94720 (United States); Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Leone, Stephen R., E-mail: srl@berkeley.edu [Department of Chemistry, University of California, Berkeley, California 94720 (United States); Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Department of Physics, University of California, Berkeley, California 94720 (United States)

    2016-03-28

    Femtosecond extreme ultraviolet (XUV) transient absorption spectroscopy based on a high-harmonic generation source is used to study the 266 nm induced A-band photodissociation dynamics of allyl iodide (CH{sub 2} =CHCH{sub 2}I). The photolysis of the C—I bond at this wavelength produces iodine atoms both in the ground ({sup 2}P{sub 3/2}, I) and spin-orbit excited ({sup 2}P{sub 1/2}, I*) states, with the latter as the predominant channel. Using XUV absorption at the iodine N{sub 4/5} edge (45–60 eV), the experiments constitute a direct probe of not only the long-lived atomic iodine reaction products but also the fleeting transition state region of the repulsive n{sub I}σ{sup ∗}{sub C—I} excited states. Specifically, three distinct features are identified in the XUV transient absorption spectrum at 45.3 eV, 47.4 eV, and 48.4 eV (denoted transients A, B, and C, respectively), which arise from the repulsive valence-excited nσ{sup ∗} states and project onto the high-lying core-excited states of the dissociating molecule via excitation of 4d(I) core electrons. Transients A and B originate from 4d(I) → n(I) core-to-valence transitions, whereas transient C is best assigned to a 4d(I) →σ{sup ∗}(C—I) transition. The measured differential absorbance of these new features along with the I/I* branching ratios known from the literature is used to suggest a more definitive assignment, albeit provisional, of the transients to specific dissociative states within the A-band manifold. The transients are found to peak around 55 fs–65 fs and decay completely by 145 fs–185 fs, demonstrating the ability of XUV spectroscopy to map the evolution of reactants into products in real time. The similarity in the energies of transients A and B with analogous features observed in methyl iodide [Attar et al. J. Phys. Chem. Lett. 6, 5072, (2015)] together with the new observation of transient C in the present work provides a more complete picture of the valence electronic

  15. Assessing local and regional economic impacts of climatic extremes and feasibility of adaptation measures in Dutch arable farming systems

    NARCIS (Netherlands)

    Diogo, V.; Reidsma, P.; Schaap, B.; Andree, B. P.J.; Koomen, E.

    2017-01-01

    We propose a method that combines local productivity factors, economic factors, crop-specific sensitivity to climatic extremes, and future climate change scenarios, to assess potential impacts of extreme weather events on agricultural production systems. Our assessment is spatially explicit and uses

  16. Incidence of Complex Regional Pain Syndrome I Following Foot and Ankle Fractures Using the Budapest Criteria.

    Science.gov (United States)

    Bullen, Michael; Lang, Coran; Tran, Phong

    2016-12-01

    OBJECTIVE : Fractures are a well-recognized inciting event in the development of complex regional pain syndrome. This study aimed to prospectively determine the incidence of complex regional pain syndrome following foot and ankle fractures. METHODS : A prospective study was conducted of patients presenting to two metropolitan hospitals with plain radiograph diagnosis of fractures to the foot or ankle. Patients were initially screened by phone 3 months after injury using the validated International Association for the Study of Pain Budapest criteria. Patients who fulfilled the screening criteria were then physically examined by a pain specialist to assess clinical signs as part of the Budapest criteria. RESULTS : A total of 306 consecutive eligible patients were included. One hundred and ten patients reported at least one symptom of complex regional pain syndrome; however, only three fulfilled the minimum requirements to necessitate clinical review. Of these three, only one patient fulfilled the combination of symptom and sign criteria for a positive diagnosis according to the validated Budapest criteria. The incidence of complex regional pain syndrome following foot and ankle fracture in this study was 0.3%. CONCLUSION : Although many patients may experience vasomotor, sensory, and sudomotor disturbance following a fracture to the foot and ankle, the observed incidence of complex regional pain syndrome using a prospectively collected validated criteria is significantly lower than previously published. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Region-specific expression of mitochondrial complex I genes during murine brain development.

    Directory of Open Access Journals (Sweden)

    Stefanie Wirtz

    Full Text Available Mutations in the nuclear encoded subunits of mitochondrial complex I (NADH:ubiquinone oxidoreductase may cause circumscribed cerebral lesions ranging from degeneration of the striatal and brainstem gray matter (Leigh syndrome to leukodystrophy. We hypothesized that such pattern of regional pathology might be due to local differences in the dependence on complex I function. Using in situ hybridization we investigated the relative expression of 33 nuclear encoded complex I subunits in different brain regions of the mouse at E11.5, E17.5, P1, P11, P28 and adult (12 weeks. With respect to timing and relative intensity of complex I gene expression we found a highly variant pattern in different regions during development. High average expression levels were detected in periods of intense neurogenesis. In cerebellar Purkinje and in hippocampal CA1/CA3 pyramidal neurons we found a second even higher peak during the period of synaptogenesis and maturation. The extraordinary dependence of these structures on complex I gene expression during synaptogenesis is in accord with our recent findings that gamma oscillations--known to be associated with higher cognitive functions of the mammalian brain--strongly depend on the complex I activity. However, with the exception of the mesencephalon, we detected only average complex I expression levels in the striatum and basal ganglia, which does not explain the exquisite vulnerability of these structures in mitochondrial disorders.

  18. Novel Signs and Their Clinical Utility in Diagnosing Complex Regional Pain Syndrome (CRPS): A Prospective Observational Cohort Study.

    Science.gov (United States)

    Kuttikat, Anoop; Shaikh, Maliha; Oomatia, Amin; Parker, Richard; Shenker, Nicholas

    2017-06-01

    Delays in diagnosis occur with complex regional pain syndrome (CRPS). We define and prospectively demonstrate that novel bedside tests measuring body perception disruption can identify patients with CRPS postfracture. The objectives of our study were to define and validate 4 bedside tests, to identify the prevalence of positive tests in patients with CRPS and other chronic pain conditions, and to assess the clinical utility (sensitivity, specificity, positive predictive value, negative predictive value) for identifying CRPS within a Fracture cohort. This was a single UK teaching hospital prospective cohort study with 313 recruits from pain-free volunteers and patients with chronic pain conditions.Four novel tests were Finger Perception (FP), Hand Laterality identification (HL), Astereognosis (AS), and Body Scheme (BS) report. Five questionnaires (Brief Pain Inventory, Upper Extremity Functional Index, Lower Extremity Functional Index, Neglect-like Symptom Questionnaire, Hospital Anxiety and Depression Score) assessed the multidimensional pain experience. FP and BS were the best performing tests. Prospective monitoring of fracture patients showed that out of 7 fracture patients (total n=47) who had both finger misperception and abnormal BS report at initial testing, 3 developed persistent pain with 1 having a formal diagnosis of CRPS. Novel signs are reliable, easy to perform, and present in chronic pain patients. FP and BS have significant clinical utility in predicting persistent pain in a fracture group thereby allowing targeted early intervention.

  19. Intravenous regional block is similar to sympathetic ganglion block for pain management in patients with complex regional pain syndrome type I

    Directory of Open Access Journals (Sweden)

    M.S.A. Nascimento

    2010-12-01

    Full Text Available Sympathetic ganglion block (SGB or intravenous regional block (IVRB has been recommended for pain management in patients with complex regional pain syndrome type I (CRPS-I. Forty-five patients were initially selected but only 43 were accepted for the study. The present study evaluated the efficacy of IVRB produced by combining 70 mg lidocaine with 30 µg clonidine (14 patients, 1 male/13 females, age range: 27-50 years versus SGB produced by the injection of 70 mg lidocaine alone (14 patients, 1 male/13 females, age range: 27-54 years or combined with 30 µg clonidine (15 patients, 1 male/14 females, age range: 25-50 years into the stellate ganglion for pain management in patients with upper extremity CRPS-I. Each procedure was repeated five times at 7-day intervals, and pain intensity and duration were measured using a visual analog scale immediately before each procedure. A progressive and significant reduction in pain scores and a significant increase in the duration of analgesia were observed in all groups following the first three blocks, but no further improvement was obtained following the last two blocks. Drowsiness, the most frequent side effect, and dry mouth occurred only in patients submitted to SGB with lidocaine combined with clonidine. The three methods were similar regarding changes in pain intensity and duration of analgesia. However, IVRB seems to be preferable to SGB due to its easier execution and lower risk of undesirable effects.

  20. Climate change impact on water resource extremes in a headwater region of the Tarim basin in China

    Directory of Open Access Journals (Sweden)

    T. Liu

    2011-11-01

    Full Text Available The Tarim river basin in China is a huge inland arid basin, which is expected to be highly vulnerable to climatic changes, given that most water resources originate from the upper mountainous headwater regions. This paper focuses on one of these headwaters: the Kaidu river subbasin. The climate change impact on the surface and ground water resources of that basin and more specifically on the hydrological extremes were studied by using both lumped and spatially distributed hydrological models, after simulation of the IPCC SRES greenhouse gas scenarios till the 2050s. The models include processes of snow and glacier melting. The climate change signals were extracted from the grid-based results of general circulation models (GCMs and applied on the station-based, observed historical data using a perturbation approach. For precipitation, the time series perturbation involves both a wet-day frequency perturbation and a quantile perturbation to the wet-day rainfall intensities. For temperature and potential evapotranspiration, the climate change signals only involve quantile based changes. The perturbed series were input into the hydrological models and the impacts on the surface and ground water resources studied. The range of impact results (after considering 36 GCM runs were summarized in high, mean, and low results. It was found that due to increasing precipitation in winter, snow accumulation increases in the upper mountainous areas. Due to temperature rise, snow melting rates increase and the snow melting periods are pushed forward in time. Although the qualitive impact results are highly consistent among the different GCM runs considered, the precise quantitative impact results varied significantly depending on the GCM run and the hydrological model.

  1. GBA manager: an online tool for querying low-complexity regions in proteins.

    Science.gov (United States)

    Bandyopadhyay, Nirmalya; Kahveci, Tamer

    2010-01-01

    Abstract We developed GBA Manager, an online software that facilitates the Graph-Based Algorithm (GBA) we proposed in our earlier work. GBA identifies the low-complexity regions (LCR) of protein sequences. GBA exploits a similarity matrix, such as BLOSUM62, to compute the complexity of the subsequences of the input protein sequence. It uses a graph-based algorithm to accurately compute the regions that have low complexities. GBA Manager is a user friendly web-service that enables online querying of protein sequences using GBA. In addition to querying capabilities of the existing GBA algorithm, GBA Manager computes the p-values of the LCR identified. The p-value gives an estimate of the possibility that the region appears by chance. GBA Manager presents the output in three different understandable formats. GBA Manager is freely accessible at http://bioinformatics.cise.ufl.edu/GBA/GBA.htm .

  2. The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity

    Directory of Open Access Journals (Sweden)

    Chen Feng-Chi

    2011-08-01

    Full Text Available Abstract Background Organismal complexity is suggested to increase with the complexity of transcriptional and translational regulations. Supporting this notion is a recent study that demonstrated a higher level of tissue-specific gene expression in human than in mouse. However, whether this correlation can be extended beyond mammals remains unclear. In addition, 5' untranslated regions (5'UTRs, which have undergone stochastic elongation during evolution and potentially included an increased number of regulatory elements, may have played an important role in the emergence of organismal complexity. Although the lack of correlation between 5'UTR length and organismal complexity has been proposed, the underlying mechanisms remain unexplored. Results In this study, we select the number of cell types as the measurement of organismal complexity and examine the correlation between (1 organismal complexity and transcriptional regulatory complexity; and (2 organismal complexity and 5'UTR length by comparing the 5'UTRs and multiple-tissue expression profiles of human (Homo sapiens, mouse (Mus musculus, and fruit fly (Drosophila melanogaster. The transcriptional regulatory complexity is measured by using the tissue specificity of gene expression and the ratio of non-constitutively expressed to constitutively expressed genes. We demonstrate that, whereas correlation (1 holds well in the three-way comparison, correlation (2 is not true. Results from a larger dataset that includes more than 15 species, ranging from yeast to human, also reject correlation (2. The reason for the failure of correlation (2 may be ascribed to: Firstly, longer 5'UTRs do not contribute to increased tissue specificity of gene expression. Secondly, the increased numbers of common translational regulatory elements in longer 5'UTRs do not lead to increased organismal complexity. Conclusions Our study has extended the evidence base for the correlation between organismal complexity and

  3. [Intermittent pneumatic compression of the lower extremity muscles in complex prophylactics of postoperative venous thromboses in elderly and senile patients].

    Science.gov (United States)

    Glushkov, N I; Openchenko, S V

    2009-01-01

    An analysis of frequency of venous thrombitic complications after different operations on 69 patients aged from 69 through 87 was made. The greatest number of venous thromboses was noted after amputations of the femur. Intermittent pneumatic compression of the lower extremities in addition to standard methods of prophylactics reduced the number of postoperative thromboses from 12.8% to 3.3%.

  4. Current state and development trends of the agroindustrial complex and rural territories of Perm Region

    Directory of Open Access Journals (Sweden)

    Gennadiy Vladimirovich Klimenkov

    2011-12-01

    Full Text Available Analysis of regional agricultural sector status and rural areas of Perm in 1990-2011 years indicates a systemic crisis of agriculture in Perm region, which is largely determined by the fact that Perm region has no strategy or strategic plan and program for sustainable agricultural sector and rural areas of Perm region development, there is no scheme of territorial development and master plans of territorial development with the development of agro-industrial complex of Perm region. In these circumstances, there is a steady downward trend in production, weakening and bankruptcy of enterprises, social impoverishment of rural areas, appearance of many of irreversible processes (sale and neglect of agricultural land, demographic problems associated with low living standards, population migration, policy optimization in the areas of education and health, union of territories, policy of depopulation of territories etc.. This paper presents main recommendations for improving the situation in agriculture of Perm region.

  5. Response of vegetation NDVI to climatic extremes in the arid region of Central Asia: a case study in Xinjiang, China

    Science.gov (United States)

    Yao, Junqiang; Chen, Yaning; Zhao, Yong; Mao, Weiyi; Xu, Xinbing; Liu, Yang; Yang, Qing

    2018-02-01

    Observed data showed the climatic transition from warm-dry to warm-wet in Xinjiang during the past 30 years and will probably affect vegetation dynamics. Here, we analyze the interannual change of vegetation index based on the satellite-derived normalized difference vegetation index (NDVI) with temperature and precipitation extreme over the Xinjiang, using the 8-km NDVI third-generation (NDVI3g) from the Global Inventory Modelling and Mapping Studies (GIMMS) from 1982 to 2010. Few previous studies analyzed the link between climate extremes and vegetation response. From the satellite-based results, annual NDVI significantly increased in the first two decades (1981-1998) and then decreased after 1998. We show that the NDVI decrease over the past decade may conjointly be triggered by the increases of temperature and precipitation extremes. The correlation analyses demonstrated that the trends of NDVI was close to the trend of extreme precipitation; that is, consecutive dry days (CDD) and torrential rainfall days (R24) positively correlated with NDVI during 1998-2010. For the temperature extreme, while the decreases of NDVI correlate positively with warmer mean minimum temperature ( Tnav), it correlates negatively with the number of warmest night days ( Rwn). The results suggest that the climatic extremes have possible negative effects on the ecosystem.

  6. Regional decision-makers as potential users of Extreme Weather Event Attribution - Case studies from the German Baltic Sea coast and the Greater Paris area

    Directory of Open Access Journals (Sweden)

    Maria Schwab

    2017-12-01

    Full Text Available Extreme Event Attribution has raised increasing attention in climate science in the last years. It means to judge the extent to which certain weather-related extreme events have changed due to human influences on climate with probabilistic statements. Extreme Event Attribution is often anticipated to spur more than just scientific ambition. It is able to provide answers to a commonly asked questions after extreme events, namely, ‘can we blame it on climate change’ and is assumed to support decision-making of various actors engaged in climate change mitigation and adaptation. More in-depth research is widely lacking about who these actors are; in which context they can make use of it; and what requirements they have, to be able to actually apply Extreme Event Attribution. We have therefore addressed these questions with two empirical case studies looking at regional decision-makers who deal with storm surge risks in the German Baltic Sea region and heat waves in the Greater Paris area. Stakeholder interviews and workshops reveal that fields of application and requirements are diverse, difficult to explicitly identify, and often clearly associated with stakeholders' specific mandate, the hazard background, and the regional socio-economic setting. Among the considered stakeholders in the Baltic Sea region, Extreme Event Attribution is perceived to be most useful to awareness-raising, in particular for climate change mitigation. They emphasised the importance of receiving understandable information - and that, rather later, but with smaller uncertainties than faster, but with higher uncertainties. In the Paris case, we typically talked to people engaged in adaptation with expertise in terms of climate science, but narrowly defined mandates which is typical for the Paris-centred political system with highly specialised public experts. The interviewees claimed that Extreme Event Attribution is most useful to political leverage and public

  7. Quantifying enhancement in aerosol radiative forcing during ‘extreme aerosol days’ in summer at Delhi National Capital Region, India

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Sumant [School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067 (India); Dey, Sagnik [Centre for Atmospheric Sciences, IIT Delhi, New Delhi 110016 (India); Srivastava, Arun [School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067 (India)

    2016-04-15

    Changes in aerosol characteristics (spectral aerosol optical depth, AOD and composition) are examined during the transition from ‘relatively clean’ to ‘extreme’ aerosol days in the summer of 2012 at Delhi National Capital Region (NCR), India. AOD smaller than 0.54 (i.e. 12-year mean AOD − 1σ) represents ‘relatively clean’ days in Delhi during the summer. ‘Extreme’ days are defined by the condition when AOD{sub 0.5} exceeds 12-year mean AOD + 1 standard deviation (σ). Mean (± 1σ) AOD increases to 1.2 ± 0.12 along with a decrease of Angstrom Exponent from 0.54 ± 0.09 to 0.22 ± 0.12 during the ‘extreme’ days. Aerosol composition is inferred by fixing the number concentrations of various individual species through iterative tweaking when simulated (following Mie theory) AOD spectrum matches with the measured one. Contribution of coarse mode dust to aerosol mass increased from 76.8% (relatively clean) to 96.8% (extreme events), while the corresponding contributions to AOD{sub 0.5} increased from 35.0% to 70.8%. Spectrally increasing single scattering albedo (SSA) and CALIPSO aerosol sub-type information support the dominant presence of dust during the ‘extreme’ aerosol days. Aerosol direct radiative forcing (ADRF) at the top-of-the-atmosphere increases from 21.2 W m{sup −2} (relatively clean) to 56.6 W m{sup −2} (extreme), while the corresponding change in surface ADRF is from − 99.5 W m{sup −2} to − 153.5 W m{sup −2}. Coarse mode dust contributes 60.3% of the observed surface ADRF during the ‘extreme’ days. On the contrary, 0.4% mass fraction of black carbon (BC) translates into 13.1% contribution to AOD{sub 0.5} and 33.5% to surface ADRF during the ‘extreme’ days. The atmospheric heating rate increased by 75.1% from 1.7 K/day to 2.96 K/day during the ‘extreme’ days. - Graphical abstract: Deviation (in %) of aerosol properties from ‘relatively clean’ days to ‘extreme’ aerosol days. - Highlights:

  8. Heterogeneous convergence of regional house prices and the complexity in China

    Directory of Open Access Journals (Sweden)

    Rui Lin

    2015-12-01

    Full Text Available The purpose of this research is to analyze the convergence of regional house prices and its complexity in China. In this purpose it used nonlinear time varying factor model. The obtained results have provided evidences for the existence of some degree of segmentation in China’s housing market. By further dynamic analysis of the convergence, we have found that important housing policies from Chinese central government can significantly alter the housing market but with a time lag of 4 to 5 months, and that quite different behaviors exist between the new house market and the second-hand house market in China, which provides the evidence for the complexity of housing market in China. Multiple factors together are the driving forces for the regional house price convergence. And the driving forces differ among three clubs. The basic conclusion provided from the realized research is that the conventional definitions of economic regions may not be appropriate to analyze house price segregation in China. Heterogeneous convergence exists in China’s regional house prices, indicating the complexity of regional house prices in China. And housing policies should be implemented with different focus among the regions. The way of the central government is to make housing policies aiming at different sub-markets of the new house market and the second-hand house market.

  9. Radar observations of a tornado-spawning storm complex in Southeast Brazil and Meso-Eta forecasts of this extreme event

    Science.gov (United States)

    Held, Gerhard; Gomes, Jorge Luis; Gomes, Ana Maria

    2014-05-01

    During the early afternoon of 22 September 2013, severe storms, accompanied by large hail, damaging winds, heavy precipitation and intense lightning activity, devastated a region in the southeast State of São Paulo. Several extremely intense storm cells moved at up to 80 km/h east-southeastwards, ahead of a strong cold front approaching through Paraná, which created extremely unstable conditions that led to deep convection and overshooting towers up to 18 km. At least one of theses cells spawned a tornado when it reached the town of Taquarituba. The tornado traversed the town from south-southwest to north-northeast and was responsible for 63 people injured and two fatalities. Based on the damage reported, it was at least an F3 according to the Fujita scale. The objective of the present study is to characterize this severe thunderstorm event, using different types of data, and to evaluate the forecasts provided by the Meso-Eta model centered over Bauru. The pre-frontal and frontal convective cells were tracked throughout their life-time by IPMet's Doppler radars, which cover the western and central regions of the State São Paulo, as well as northern Paraná State. Radar volume scans, generated every 7,5 min, were processed with the TITAN (Thunderstorm Identification, Tracking, Analysis and Nowcasting) Software, yielding the following preliminary results: as the storm complex traversed the Paranapanema River, which forms the border between the two states, the cells intensified drastically and shortly before reaching the town of Taquarituba, that particular cell displayed extremely strong radial shear just above the cloud base (about -20 to +35 m/s), which led to the formation of a deep meso-cyclone, from which the tornado spawned and touched down at around 14:30 LT (LT=UT-3h). Cell properties calculated by TITAN showed a drastic increase of VIL (Vertically Integrated Liquid water content) from 13:52 LT (7,9 kg/m2) to a maximum of 61,8 kg/m2 at 14:15 LT. From 14

  10. Formation of competitive potential of the machine-building complex of the region

    Directory of Open Access Journals (Sweden)

    Oleg Ivanovich Botkin

    2014-03-01

    Full Text Available The article describes the features of competitive potential of regional machine-building complex in a globalized world economy. The purpose of the research is the development of theoretically reasonable economic basis of the machine-building complex considering  the  features of business in the conditions of the WTO. In the work, the hypothesis of a special role of the external economic factors locates in development of the enterprises of regional industrial complexes. The study of the theoretical provisions defining the development of the region revealed the factors determining influence of the international trade agreements on spatial localization of the industry. The main attention is paid to an analytical assessment of the current state and the trends, which have developed in the period of post-crisis economic recovery. Analysis of the main indicators of attractiveness has revealed the weak position of local industrial enterprises in the WTO. The directions of strengthening of the competitive capacity of the local industrial enterprises are defined. The obtained results allow us to increase the sustainability of the industry by means of effective management mechanism improvements and to create favorable operating conditions of a machine-building complex of the region

  11. Complex regional pain syndrome related movement disorders : studies on pathophysiology and therapy.

    NARCIS (Netherlands)

    Munts, Alexander Gerard

    2011-01-01

    Complex regional pain syndrome (CRPS) may occur after trauma, usually to one limb, and is characterised by pain and disturbed blood flow, temperature regulation and motor control. Knowledge on CRPS and its movement disorders is scarce. Dysfunction in small nerve fiber processing was found in CRPS

  12. Mitochondrial dysfunction in muscle tissue of complex regional pain syndrome type I patients

    NARCIS (Netherlands)

    Tan, E.C.T.H.; Janssen, A.J.W.M.; Roestenberg, P.M.H.; Heuvel, L.P.W.J. van den; Goris, R.J.A.; Rodenburg, R.J.T.

    2011-01-01

    Reactive oxygen species (ROS) are known to be involved in the pathophysiology of complex regional pain syndrome type I (CRPS I). Since the mitochondrial respiratory chain is a major source of ROS, we hypothesized that mitochondria play a role in the pathophysiology of CRPS I. The hypothesis was

  13. Evidence for local inflammation in complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Frank J. P. M. Huygen

    2002-01-01

    Full Text Available Background: The pathophysiology of complex regional pain syndrome type 1 (CRPS 1 is still a matter of debate. Peripheral afferent, efferent and central mechanisms are supposed. Based on clinical signs and symptoms (e.g. oedema, local temperature changes and chronic pain local inflammation is suspected.

  14. Dystonia in complex regional pain syndrome : clinical, pathophysiological and therapeutic aspects

    NARCIS (Netherlands)

    Rijn, Monica Adriana van

    2010-01-01

    The clinical characteristics of Complex Regional Pain Syndrome (CRPS) are defined by pain and various combinations of sensory disturbances, autonomic features, and sudomotor and trophic changes. Furthermore, patients with CRPS may suffer from movement disorders, of which dystonia is the most

  15. Muscle Hyperalgesia Correlates With Motor Function in Complex Regional Pain Syndrome Type 1

    NARCIS (Netherlands)

    van Rooijen, Diana E.; Marinus, Johan; Schouten, Alfred Christiaan; Noldus, Lucas P.J.J.; van Hilten, Jacobus J.

    2013-01-01

    At present it is unclear if disturbed sensory processing plays a role in the development of the commonly observed motor impairments in patients with complex regional pain syndrome (CRPS). This study aims to investigate the relation between sensory and motor functioning in CRPS patients with and

  16. Genetic HLA Associations in Complex Regional Pain Syndrome With and Without Dystonia

    NARCIS (Netherlands)

    van Rooijen, D.E.; Roelen, D.L.; Verduijn, W.; Haasnoot, G.W.; Huygen, F.J.P.M.; Perez, R.S.G.M.; Claas, F.H.J.; Marinus, J.; van Hilten, J.J.; van den Maagdenberg, A.M.J.M.

    2012-01-01

    We previously showed evidence for a genetic association of the human leukocyte antigen (HLA) system and complex regional pain syndrome (CRPS) with dystonia. Involvement of the HLA system suggests that CRPS has a genetic component with perturbed regulation of inflammation and neuroplasticity as

  17. Informed Decision-Making Regarding Amputation for Complex Regional Pain Syndrome Type I

    NARCIS (Netherlands)

    Bodde, Marlies I.; Dijkstra, Pieter U.; Schrier, Michiel; van den Dungen, Johannes; den Dunnen, Wilfred E.; Geertzen, Joannes

    2014-01-01

    Background: Literature on complex regional pain syndrome type I (CRPS-I) discussing the decision to amputate or not, the level of amputation, or the timing of the amputation is scarce: We evaluated informed decision-making regarding amputation for CRPS-I. Methods: We describe our findings in a

  18. ECOLOGICAL SAFETY OF MINING REGIONS THROUGH CREATION OF POWER‐HEATING COMPLEXES (in Russian

    Directory of Open Access Journals (Sweden)

    I. A. YEFREMOV

    2014-04-01

    Full Text Available There was presented a method of use of alterative source of energy, namely coal mine methane, the use of which as a fuel for power and heatiing generation is a main direction in coal mines. By this means some ecological problems of the region are solved. Highly efficient power and heating technologies are implemented and energy complexes are established.

  19. Ecosystem services provided by a complex coastal region: challenges of classification and mapping

    Science.gov (United States)

    Sousa, Lisa P.; Sousa, Ana I.; Alves, Fátima L.; Lillebø, Ana I.

    2016-03-01

    A variety of ecosystem services classification systems and mapping approaches are available in the scientific and technical literature, which needs to be selected and adapted when applied to complex territories (e.g. in the interface between water and land, estuary and sea). This paper provides a framework for addressing ecosystem services in complex coastal regions. The roadmap comprises the definition of the exact geographic boundaries of the study area; the use of CICES (Common International Classification of Ecosystem Services) for ecosystem services identification and classification; and the definition of qualitative indicators that will serve as basis to map the ecosystem services. Due to its complexity, the Ria de Aveiro coastal region was selected as case study, presenting an opportunity to explore the application of such approaches at a regional scale. The main challenges of implementing the proposed roadmap, together with its advantages are discussed in this research. The results highlight the importance of considering both the connectivity of natural systems and the complexity of the governance framework; the flexibility and robustness, but also the challenges when applying CICES at regional scale; and the challenges regarding ecosystem services mapping.

  20. Cerebral activation during motor imagery in complex regional pain syndrome type 1 with dystonia

    NARCIS (Netherlands)

    Gieteling, Esther W.; van Rijn, Monique A.; de Jong, Bauke M.; Hoogduin, Johannes M.; Renken, Remco; van Hilten, Jacobus J.; Leenders, Klaus L.

    The pathogenesis of dystonia in Complex Regional Pain Syndrome type 1 (CRPS-1) is unclear. In primary dystonia, functional magnetic resonance imaging (fMRI) has revealed changes in cerebral networks during execution of movement. The aim of this study was to determine cerebral network function in

  1. Regional and Historical Minerageny of the Gemstone Complexes in Russia (Quantitative Aspects

    Directory of Open Access Journals (Sweden)

    Polyanin V.S.

    2015-06-01

    Full Text Available The paper presents an approximate quantitative estimation of the mineragenic potentials of gems in the paleogeodynamic systems, complexes, and geological formations of Russia, which are characterized by different age and regional distribution. General trends of the changes in the scale and intensity of formation processes of the same gem deposits over geologic time were identified.

  2. Complex regional pain syndrome 1 : a study on pain and motor impairments

    NARCIS (Netherlands)

    G.M. Ribbers (Gerard)

    2001-01-01

    textabstractThis thesis, is compiled of publications on reflex sympathetic dystrophy (RSD) or Complex Regional Pain Syndrome type 1 (CRPS 1), as it was renamed by the committee on taxonomy of the International Association for the Study of Pain (IASP). It is a puzzling syndrome both from a clinical

  3. Modelling of the flow of stable air over a complex region

    CSIR Research Space (South Africa)

    Scholtz, MT

    1976-01-01

    Full Text Available The flow of stable air over a general region of complex topography and non-uniform surface temperature has been investigated. In order to gain further understanding of the motion of surface air, it was necessary to study the vertical structure...

  4. Stressful life events and psychological dysfunction in complex regional pain syndrome type I

    NARCIS (Netherlands)

    Geertzen, JHB; de Bruijn-Kofman, AT; de Bruijn, HP; van de Wiel, HBM; Dijkstra, PU

    Objective: To determine to what extent stressful life events and psychological dysfunction play a role in the pathogenesis of Complex Regional Pain Syndrome type I (CRPS). Design: A comparative study between a CRPS group and a control group. Stressful life events and psychological dysfunction

  5. Ecosystem services provided by a complex coastal region: challenges of classification and mapping.

    Science.gov (United States)

    Sousa, Lisa P; Sousa, Ana I; Alves, Fátima L; Lillebø, Ana I

    2016-03-11

    A variety of ecosystem services classification systems and mapping approaches are available in the scientific and technical literature, which needs to be selected and adapted when applied to complex territories (e.g. in the interface between water and land, estuary and sea). This paper provides a framework for addressing ecosystem services in complex coastal regions. The roadmap comprises the definition of the exact geographic boundaries of the study area; the use of CICES (Common International Classification of Ecosystem Services) for ecosystem services identification and classification; and the definition of qualitative indicators that will serve as basis to map the ecosystem services. Due to its complexity, the Ria de Aveiro coastal region was selected as case study, presenting an opportunity to explore the application of such approaches at a regional scale. The main challenges of implementing the proposed roadmap, together with its advantages are discussed in this research. The results highlight the importance of considering both the connectivity of natural systems and the complexity of the governance framework; the flexibility and robustness, but also the challenges when applying CICES at regional scale; and the challenges regarding ecosystem services mapping.

  6. Resilience in patients with amputation because of Complex Regional Pain Syndrome type I

    NARCIS (Netherlands)

    Bodde, Marlies I.; Schrier, Ernst; Krans, Hilde K.; Geertzen, J.H.B.; Dijkstra, Pieter U.

    2014-01-01

    Purpose: Although controversial, an amputation for longstanding and therapy-resistant Complex Regional Pain Syndrome Type I (CRPS-I) may improve quality of life and pain intensity. Resilience, the way people deal with adversity in a positive way may be related to these positive outcomes. This study

  7. Optokinetic stimulation increases limb pain and forehead hyperalgesia in complex regional pain syndrome

    DEFF Research Database (Denmark)

    Knudsen, Lone F.; Drummond, Peter D.

    2015-01-01

    BACKGROUND: Ambiguous visual stimuli increase limb pain in patients with complex regional pain syndrome (CRPS), possibly due to afferent sensory feedback conflicts. Conflicting sensory stimuli can also generate unpleasant sensations in healthy people such as during motion sickness. We wanted to i...

  8. Changes of precipitation and extremes and the possible effect of urbanization in the Beijing metropolitan region during 1960-2012 based on homogenized observations

    Science.gov (United States)

    Li, Zhen; Yan, Zhongwei; Tu, Kai; Wu, Hongyi

    2015-09-01

    Daily precipitation series at 15 stations in the Beijing metropolitan region (BMR) during 1960-2012 were homogenized using the multiple analysis of series for homogenization method, with additional adjustments based on analysis of empirical cumulative density function (ECDF) regarding climate extremes. The cumulative density functions of daily precipitation series, the trends of annual and seasonal precipitation, and summer extreme events during 1960-2012 in the original and final adjusted series at Beijing station were comparatively analyzed to show the necessity and efficiency of the new method. Results indicate that the ECDF adjustments can improve the homogeneity of high-order moments of daily series and the estimation of climate trends in extremes. The linear trends of the regional-mean annual and seasonal (spring, summer, autumn, and winter) precipitation series are -10.16, 4.97, -20.04, 5.02, and -0.11 mm (10 yr)-1, respectively. The trends over the BMR increase consistently for spring/autumn and decrease for the whole year/summer; however, the trends for winter decrease in southern parts and increase in northern parts. Urbanization affects local trends of precipitation amount, frequency, and intensity and their geographical patterns. For the urban-influenced sites, urbanization tends to slow down the magnitude of decrease in the precipitation and extreme amount series by approximately -10.4% and -6.0%, respectively; enhance the magnitude of decrease in precipitation frequency series by approximately 5.7%; reduce that of extremes by approximately -8.9%; and promote the decreasing trends in the summer intensity series of both precipitation and extremes by approximately 6.8% and 51.5%, respectively.

  9. Determination of haplotypes at structurally complex regions using emulsion haplotype fusion PCR.

    Science.gov (United States)

    Tyson, Jess; Armour, John A L

    2012-12-11

    Genotyping and massively-parallel sequencing projects result in a vast amount of diploid data that is only rarely resolved into its constituent haplotypes. It is nevertheless this phased information that is transmitted from one generation to the next and is most directly associated with biological function and the genetic causes of biological effects. Despite progress made in genome-wide sequencing and phasing algorithms and methods, problems assembling (and reconstructing linear haplotypes in) regions of repetitive DNA and structural variation remain. These dynamic and structurally complex regions are often poorly understood from a sequence point of view. Regions such as these that are highly similar in their sequence tend to be collapsed onto the genome assembly. This is turn means downstream determination of the true sequence haplotype in these regions poses a particular challenge. For structurally complex regions, a more focussed approach to assembling haplotypes may be required. In order to investigate reconstruction of spatial information at structurally complex regions, we have used an emulsion haplotype fusion PCR approach to reproducibly link sequences of up to 1kb in length to allow phasing of multiple variants from neighbouring loci, using allele-specific PCR and sequencing to detect the phase. By using emulsion systems linking flanking regions to amplicons within the CNV, this led to the reconstruction of a 59kb haplotype across the DEFA1A3 CNV in HapMap individuals. This study has demonstrated a novel use for emulsion haplotype fusion PCR in addressing the issue of reconstructing structural haplotypes at multiallelic copy variable regions, using the DEFA1A3 locus as an example.

  10. Determination of haplotypes at structurally complex regions using emulsion haplotype fusion PCR

    Directory of Open Access Journals (Sweden)

    Tyson Jess

    2012-12-01

    Full Text Available Abstract Background Genotyping and massively-parallel sequencing projects result in a vast amount of diploid data that is only rarely resolved into its constituent haplotypes. It is nevertheless this phased information that is transmitted from one generation to the next and is most directly associated with biological function and the genetic causes of biological effects. Despite progress made in genome-wide sequencing and phasing algorithms and methods, problems assembling (and reconstructing linear haplotypes in regions of repetitive DNA and structural variation remain. These dynamic and structurally complex regions are often poorly understood from a sequence point of view. Regions such as these that are highly similar in their sequence tend to be collapsed onto the genome assembly. This is turn means downstream determination of the true sequence haplotype in these regions poses a particular challenge. For structurally complex regions, a more focussed approach to assembling haplotypes may be required. Results In order to investigate reconstruction of spatial information at structurally complex regions, we have used an emulsion haplotype fusion PCR approach to reproducibly link sequences of up to 1kb in length to allow phasing of multiple variants from neighbouring loci, using allele-specific PCR and sequencing to detect the phase. By using emulsion systems linking flanking regions to amplicons within the CNV, this led to the reconstruction of a 59kb haplotype across the DEFA1A3 CNV in HapMap individuals. Conclusion This study has demonstrated a novel use for emulsion haplotype fusion PCR in addressing the issue of reconstructing structural haplotypes at multiallelic copy variable regions, using the DEFA1A3 locus as an example.

  11. Complex Networks Dynamics Based on Events-Phase Synchronization and Intensity Correlation Applied to The Anomaly Patterns and Extremes in The Tropical African Climate System

    Science.gov (United States)

    Oluoch, K.; Marwan, N.; Trauth, M.; Loew, A.; Kurths, J.

    2012-04-01

    The African continent lie almost entirely within the tropics and as such its (tropical) climate systems are predominantly governed by the heterogeneous, spatial and temporal variability of the Hadley and Walker circulations. The variabilities in these meridional and zonal circulations lead to intensification or suppression of the intensities, durations and frequencies of the Inter-tropical Convergence Zone (ICTZ) migration, trade winds and subtropical high-pressure regions and the continental monsoons. The above features play a central role in determining the African rainfall spatial and temporal variability patterns. The current understanding of these climate features and their influence on the rainfall patterns is not sufficiently understood. Like many real-world systems, atmospheric-oceanic processes exhibit non-linear properties that can be better explored using non-linear (NL) methods of time-series analysis. Over the recent years, the complex network approach has evolved as a powerful new player in understanding spatio-temporal dynamics and evolution of complex systems. Together with NL techniques, it is continuing to find new applications in many areas of science and technology including climate research. We would like to use these two powerful methods to understand the spatial structure and dynamics of African rainfall anomaly patterns and extremes. The method of event synchronization (ES) developed by Quiroga et al., 2002 and first applied to climate networks by Malik et al., 2011 looks at correlations with a dynamic time lag and as such, it is a more intuitive way to correlate a complex and heterogeneous system like climate networks than a fixed time delay most commonly used. On the other hand, the short comings of ES is its lack of vigorous test statistics for the significance level of the correlations, and the fact that only the events' time indices are synchronized while all information about how the relative intensities propagate within network

  12. Independent variable complexity for regional regression of the flow duration curve in ungauged basins

    Science.gov (United States)

    Fouad, Geoffrey; Skupin, André; Hope, Allen

    2016-04-01

    The flow duration curve (FDC) is one of the most widely used tools to quantify streamflow. Its percentile flows are often required for water resource applications, but these values must be predicted for ungauged basins with insufficient or no streamflow data. Regional regression is a commonly used approach for predicting percentile flows that involves identifying hydrologic regions and calibrating regression models to each region. The independent variables used to describe the physiographic and climatic setting of the basins are a critical component of regional regression, yet few studies have investigated their effect on resulting predictions. In this study, the complexity of the independent variables needed for regional regression is investigated. Different levels of variable complexity are applied for a regional regression consisting of 918 basins in the US. Both the hydrologic regions and regression models are determined according to the different sets of variables, and the accuracy of resulting predictions is assessed. The different sets of variables include (1) a simple set of three variables strongly tied to the FDC (mean annual precipitation, potential evapotranspiration, and baseflow index), (2) a traditional set of variables describing the average physiographic and climatic conditions of the basins, and (3) a more complex set of variables extending the traditional variables to include statistics describing the distribution of physiographic data and temporal components of climatic data. The latter set of variables is not typically used in regional regression, and is evaluated for its potential to predict percentile flows. The simplest set of only three variables performed similarly to the other more complex sets of variables. Traditional variables used to describe climate, topography, and soil offered little more to the predictions, and the experimental set of variables describing the distribution of basin data in more detail did not improve predictions

  13. Young stellar population and star formation history ofW4 HII region/Cluster Complex

    Science.gov (United States)

    Panwar, Neelam

    2018-04-01

    The HII region/cluster complex has been a subject of numerous investigations to study the feedback effect of massive stars on their surroundings. Massive stars not only alter the morphology of the parental molecular clouds, but also influence star formation, circumstellar disks and the mass function of low-mass stars in their vicinity. However, most of the studies of low-mass stellar content of the HII regions are limited only to the nearby regions. We study the star formation in the W4 HII region using deep optical observations obtained with the archival data from Canada - France - Hawaii Telescope, Two-Micron All Sky Survey, Spitzer, Herschel and Chandra. We investigate the spatial distribution of young stellar objects in the region, their association with the remnant molecular clouds, and search for the clustering to establish the sites of recent star formation. Our analysis suggests that the influence of massive stars on circumstellar disks is significant only to thei! r immediate neighborhood. The spatial correlation of the young stars with the distribution of gas and dust of the complex indicate that the clusters would have formed in a large filamentary cloud. The observing facilities at the 3.6-m Devasthal Optical Telescope (DOT), providing high-resolution spectral and imaging capabilities, will fulfill the major objectives in the study of HII regions.

  14. A cross-sectional retrospective analysis of the regionalization of complex surgery.

    Science.gov (United States)

    Studnicki, James; Craver, Christopher; Blanchette, Christopher M; Fisher, John W; Shahbazi, Sara

    2014-08-16

    longest lengths of stay were found in higher volume hospitals. Complex surgery in Florida is effectively regionalized so that small volume hospitals operating within the range of complex procedures appropriate to their capabilities provide no increased risk of post surgical mortality.

  15. [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity].

    Science.gov (United States)

    Hara, Kenju; Watanabe, Osamu; Shibano, Ken; Ishiguro, Hideaki

    2012-01-01

    A 21-year-old man complained of severe pain and muscle twitching localized in his right arm. Neurological examination showed muscle fasciculations in his right forearm but no myokymia or myotonia. Needle electromyography revealed fibrillation potentials in his biceps brachii muscle and extensor carpi radialis muscle at rest but no myokymic discharges. His serum anti-voltage-gated potassium channel (VGKC)-complex antibody level was significantly high (194.2pM; controls VGKC-complex antibody associated disorder.

  16. The use of modern methods for complex studies of the hydrotechnical structures of the Barents Sea region

    Directory of Open Access Journals (Sweden)

    Mel'nikov N. N

    2017-03-01

    Full Text Available The Barents region hydrotechnical structures (HTS as part of the bulk earth dams and levees tailings of mining enterprises in terms of requirements of the responsible entities have been considered. The brief review of emergencies and accidents of HTS with an analysis of their causes and geo-ecological consequences has been fulfilled. The necessity and urgency of the application of modern techniques for comprehensive research and monitoring of the HTS state have been shown: geo-fluid mechanics computer modeling, subsurface georadar sensing, GPS geodetic measurements, optical and radar satellite imagery. Joint use of GPR and satellite imagery in combination with traditional engineering-geological, hydro-geological and geodetic studies allows obtaining a more complete picture of the HTS state taking into account local and regional geological and fluid dynamic processes. The system structure of HTS complex researches which creates a scientific and technical basis for researching the geologic-geophysical environment, shifts, deformations and power influence has been developed. This allows to reveal the hidden filtration and deformation zones in HTS at early stages of their formation and in due time to make the administrative decision on prevention and localization of any emergency. Application of modern methods for HTS complex researches will allow to receive operational information on their state, parametrical sizes of volume, angular and linear deformations and movements, intensity of natural and technogenic influence. The obtained data have to be integrated in the "Database and Parameters" geoportal by means of which their logical processing and comparison to standard and extreme values has to be carried out. On this basis expert assessment of the current and expected state of HTS is carried out and the operating decisions including on development, in case of need, of preventive and protective measures are made

  17. Simulating Complex, Cold-region Process Interactions Using a Multi-scale, Variable-complexity Hydrological Model

    Science.gov (United States)

    Marsh, C.; Pomeroy, J. W.; Wheater, H. S.

    2017-12-01

    Accurate management of water resources is necessary for social, economic, and environmental sustainability worldwide. In locations with seasonal snowcovers, the accurate prediction of these water resources is further complicated due to frozen soils, solid-phase precipitation, blowing snow transport, and snowcover-vegetation-atmosphere interactions. Complex process interactions and feedbacks are a key feature of hydrological systems and may result in emergent phenomena, i.e., the arising of novel and unexpected properties within a complex system. One example is the feedback associated with blowing snow redistribution, which can lead to drifts that cause locally-increased soil moisture, thus increasing plant growth that in turn subsequently impacts snow redistribution, creating larger drifts. Attempting to simulate these emergent behaviours is a significant challenge, however, and there is concern that process conceptualizations within current models are too incomplete to represent the needed interactions. An improved understanding of the role of emergence in hydrological systems often requires high resolution distributed numerical hydrological models that incorporate the relevant process dynamics. The Canadian Hydrological Model (CHM) provides a novel tool for examining cold region hydrological systems. Key features include efficient terrain representation, allowing simulations at various spatial scales, reduced computational overhead, and a modular process representation allowing for an alternative-hypothesis framework. Using both physics-based and conceptual process representations sourced from long term process studies and the current cold regions literature allows for comparison of process representations and importantly, their ability to produce emergent behaviours. Examining the system in a holistic, process-based manner can hopefully derive important insights and aid in development of improved process representations.

  18. Identification of Extreme Events Under Climate Change Conditions Over Europe and The Northwest-atlantic Region: Spatial Patterns and Time Series Characteristics

    Science.gov (United States)

    Leckebusch, G.; Ulbrich, U.; Speth, P.

    In the context of climate change and the resulting possible impacts on socio-economic conditions for human activities it seems that due to a changed occurrence of extreme events more severe consequences have to be expected than from changes in the mean climate. These extreme events like floods, excessive heats and droughts or windstorms possess impacts on human social and economic life in different categories such as forestry, agriculture, energy use, tourism and the reinsurance business. Reinsurances are affected by nearly 70% of all insured damages over Europe in the case of wind- storms. Especially the December 1999 French windstorms caused damages about 10 billion. A new EU-founded project (MICE = Modelling the Impact of Climate Ex- tremes) will focus on these impacts caused by changed occurrences of extreme events over Europe. Based upon the output of general circulation models as well as regional climate models, investigations are carried out with regard to time series characteristics as well as the spatial patterns of extremes under climate changed conditions. After the definition of specific thresholds for climate extremes, in this talk we will focus on the results of the analysis for the different data sets (HadCM3 and CGCMII GCM's and RCM's, re-analyses, observations) with regard to windstorm events. At first the results of model outputs are validated against re-analyses and observations. Especially a comparison of the stormtrack (2.5 to 8 day bandpass filtered 500 hPa geopotential height), cyclone track, cyclone frequency and intensity is presented. Highly relevant to damages is the extreme wind near the ground level, so the 10 m wind speed will be investigated additionally. of special interest to possible impacts is the changed spatial occurrence of windspeed maxima under 2xCO2-induced climate change.

  19. The Responsive Amygdala: Treatment-induced Alterations in Functional Connectivity in Pediatric Complex Regional Pain Syndrome

    Science.gov (United States)

    Simons, LE; Pielech, M; Erpelding, N; Linnman, C; Moulton, E; Sava, S; Lebel, A; Serrano, P; Sethna, N; Berde, C; Becerra, L; Borsook, D

    2014-01-01

    The amygdala is a key brain region with efferent and afferent neural connections that involve complex behaviors such as pain, reward, fear and anxiety. This study evaluated resting state functional connectivity of the amygdala with cortical and subcortical regions in a group of chronic pain patients (pediatric complex regional pain syndrome) with age-gender matched controls before and after intensive physical-biobehavioral pain treatment. Our main findings include (1) enhanced functional connectivity from the amygdala to multiple cortical, subcortical, and cerebellar regions in patients compared to controls, with differences predominantly in the left amygdala in the pre-treated condition (disease state); (2) dampened hyperconnectivity from the left amygdala to the motor cortex, parietal lobe, and cingulate cortex after intensive pain rehabilitation treatment within patients with nominal differences observed among healthy controls from Time 1 to Time 2 (treatment effects); (3) functional connectivity to several regions key to fear circuitry (prefrontal cortex, bilateral middle temporal lobe, bilateral cingulate, hippocampus) correlated with higher pain-related fear scores and (4) decreases in pain-related fear associated with decreased connectivity between the amygdala and the motor and somatosensory cortex, cingulate, and frontal areas. Our data suggest that there are rapid changes in amygdala connectivity following an aggressive treatment program in children with chronic pain and intrinsic amygdala functional connectivity activity serving as a potential indicator of treatment response. PMID:24861582

  20. The role of extreme orbits in the global organization of periodic regions in parameter space for one dimensional maps

    Science.gov (United States)

    da Costa, Diogo Ricardo; Hansen, Matheus; Guarise, Gustavo; Medrano-T, Rene O.; Leonel, Edson D.

    2016-04-01

    We show that extreme orbits, trajectories that connect local maximum and minimum values of one dimensional maps, play a major role in the parameter space of dissipative systems dictating the organization for the windows of periodicity, hence producing sets of shrimp-like structures. Here we solve three fundamental problems regarding the distribution of these sets and give: (i) their precise localization in the parameter space, even for sets of very high periods; (ii) their local and global distributions along cascades; and (iii) the association of these cascades to complicate sets of periodicity. The extreme orbits are proved to be a powerful indicator to investigate the organization of windows of periodicity in parameter planes. As applications of the theory, we obtain some results for the circle map and perturbed logistic map. The formalism presented here can be extended to many other different nonlinear and dissipative systems.

  1. ON MAGNETIC ACTIVITY BAND OVERLAP, INTERACTION, AND THE FORMATION OF COMPLEX SOLAR ACTIVE REGIONS

    Energy Technology Data Exchange (ETDEWEB)

    McIntosh, Scott W. [High Altitude Observatory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307 (United States); Leamon, Robert J., E-mail: mscott@hao.ucar.edu [Department of Physics, Montana State University, Bozeman, MT 59717 (United States)

    2014-11-20

    Recent work has revealed a phenomenological picture of the how the ∼11 yr sunspot cycle of the Sun arises. The production and destruction of sunspots is a consequence of the latitudinal-temporal overlap and interaction of the toroidal magnetic flux systems that belong to the 22 yr magnetic activity cycle and are rooted deep in the Sun's convective interior. We present a conceptually simple extension of this work, presenting a hypothesis on how complex active regions can form as a direct consequence of the intra- and extra-hemispheric interaction taking place in the solar interior. Furthermore, during specific portions of the sunspot cycle, we anticipate that those complex active regions may be particularly susceptible to profoundly catastrophic breakdown, producing flares and coronal mass ejections of the most severe magnitude.

  2. The comparative osteology of the petrotympanic complex (ear region of extant baleen whales (Cetacea: Mysticeti.

    Directory of Open Access Journals (Sweden)

    Eric G Ekdale

    Full Text Available Anatomical comparisons of the ear region of baleen whales (Mysticeti are provided through detailed osteological descriptions and high-resolution photographs of the petrotympanic complex (tympanic bulla and petrosal bone of all extant species of mysticete cetaceans. Salient morphological features are illustrated and identified, including overall shape of the bulla, size of the conical process of the bulla, morphology of the promontorium, and the size and shape of the anterior process of the petrosal. We place our comparative osteological observations into a phylogenetic context in order to initiate an exploration into petrotympanic evolution within Mysticeti.The morphology of the petrotympanic complex is diagnostic for individual species of baleen whale (e.g., sigmoid and conical processes positioned at midline of bulla in Balaenoptera musculus; confluence of fenestra cochleae and perilymphatic foramen in Eschrichtius robustus, and several mysticete clades are united by derived characteristics. Balaenids and neobalaenids share derived features of the bulla, such as a rhomboid shape and a reduced anterior lobe (swelling in ventral aspect, and eschrichtiids share derived morphologies of the petrosal with balaenopterids, including loss of a medial promontory groove and dorsomedial elongation of the promontorium. Monophyly of Balaenoidea (Balaenidae and Neobalaenidae and Balaenopteroidea (Balaenopteridae and Eschrichtiidae was recovered in phylogenetic analyses utilizing data exclusively from the petrotympanic complex.This study fills a major gap in our knowledge of the complex structures of the mysticete petrotympanic complex, which is an important anatomical region for the interpretation of the evolutionary history of mammals. In addition, we introduce a novel body of phylogenetically informative characters from the ear region of mysticetes. Our detailed anatomical descriptions, illustrations, and comparisons provide valuable data for current and

  3. The sodium pentothal hypnosis interview with follow-up treatment for complex regional pain syndrome.

    Science.gov (United States)

    Simon, E P; Dahl, L F

    1999-08-01

    A patient who was unresponsive to multiple conservative medical treatments for complex regional pain syndrome was assessed using a novel approach--the sodium pentothal hypnosis interview. The interview suggested that his pain was centrally generated. The patient's pain symptoms resolved with hypnotherapeutic treatment. Indications for this procedure and implications for assessment and treatment are discussed. This case raises more questions than it answers, and leaves the reader to struggle with current difficulties in diagnostic decision-making.

  4. Regional labour market analysis and policy evaluation: Job insecurity, flexibility and complexity. Evidence from Switzerland

    OpenAIRE

    Baruffini, Moreno; Maggi, Rico

    2014-01-01

    The thesis focuses on labour market flexibility, security and complexity. The research is divided into three chapters: two of the chapters specifically relate to perceived security, flexibility and job satisfaction, using data from the longitudinal Swiss Household Panel (SHP), while the last investigates labour market programs and their impact on a regional labour market. The first essay analyses perceptions of economic insecurity in Switzerland, during the business cycle between 2008 an...

  5. Child Abuse and Dissociation in Patients with Complex Regional Pain Syndrome

    Directory of Open Access Journals (Sweden)

    Michael Williams

    1999-01-01

    Full Text Available >OBJECTIVE: In the absence of a proven medical explanation for the chronic pain syndrome Complex Regional Pain Syndrome type I (CRPS I, this study explored a hypothetical link between childhood physical and sexual abuse, and the subsequent development of CRPS I. The hypothesis predicts the existence of a subpopulation of CRPS I patients with a high frequency of dissociative experiences corresponding to a history of childhood trauma.

  6. Geographic/conceptual delimitation of the «Southern Mediterranean». A Regional Security Complex?

    Directory of Open Access Journals (Sweden)

    Alberto Priego Moreno

    2016-07-01

    Full Text Available This article seeks to analyse how the Mediterranean Area has evolved after the changes occurred with the so-called Arab Springs. The main idea is to focus on the Southern Mediterranean as a dynamic space that expands itself as a result of its internal transformations and subsequent external changes caused by the Arab Spring. We will use the IR theory of the Regional Security Complex as it is considered as the most adaptable to this changing reality.

  7. Evaluation of low level laser and interferential current in the therapy of complex regional pain syndrome by infrared thermographic camera

    Directory of Open Access Journals (Sweden)

    Kocić Mirjana

    2010-01-01

    Full Text Available Background/Aim. Complex regional pain syndrome type I (CRPS I is characterized by continuous regional pain, disproportional according to duration and intensity and to the sort of trauma or other lesion it was caused by. The aim of the study was to evaluate and compare, by using thermovison, the effects of low level laser therapy and therapy with interferential current in treatment of CRPS I. Methods. The prospective randomized controlled clinical study included 45 patients with unilateral CRPS I, after a fracture of the distal end of the radius, of the tibia and/or the fibula, treated in the Clinical Centre in Nis from 2004 to 2007. The group A consisted of 20 patients treated by low level laser therapy and kinesy-therapy, while the patients in the group B (n = 25 were treated by interferential current and kinesy-therapy. The regions of interest were filmed by a thermovision camera on both sides, before and after the 20 therapeutic procedures had been applied. Afterwards, the quantitative analysis and the comparing of thermograms taken before and after the applied therapy were performed. Results. There was statistically significant decrease of the mean maximum temperature difference between the injured and the contralateral extremity after the therapy in comparison to the status before the therapy, with the patients of the group A (p < 0.001 as well as those of the group B (p < 0.001. The decrease was statistically significantly higher in the group A than in the group B (p < 0.05. Conclusions. By the use of the infrared thermovision we showed that in the treatment of CRPS I both physical medicine methods were effective, but the effectiveness of laser therapy was statistically significantly higher compared to that of the interferential current therapy.

  8. "Bunched Black Swans" in Complex Geosystems: Cross-Disciplinary Approaches to the Additive and Multiplicative Modelling of Correlated Extreme Bursts

    Science.gov (United States)

    Watkins, N. W.; Rypdal, M.; Lovsletten, O.

    2012-12-01

    For all natural hazards, the question of when the next "extreme event" (c.f. Taleb's "black swans") is expected is of obvious importance. In the environmental sciences users often frame such questions in terms of average "return periods", e.g. "is an X meter rise in the Thames water level a 1-in-Y year event ?". Frequently, however, we also care about the emergence of correlation, and whether the probability of several big events occurring in close succession is truly independent, i.e. are the black swans "bunched". A "big event", or a "burst", defined by its integrated signal above a threshold, might be a single, very large, event, or, instead, could in fact be a correlated series of "smaller" (i.e. less wildly fluctuating) events. Several available stochastic approaches provide quantitative information about such bursts, including Extreme Value Theory (EVT); the theory of records; level sets; sojourn times; and models of space-time "avalanches" of activity in non-equilibrium systems. Some focus more on the probability of single large events. Others are more concerned with extended dwell times above a given spatiotemporal threshold: However, the state of the art is not yet fully integrated, and the above-mentioned approaches differ in fundamental aspects. EVT is perhaps the best known in the geosciences. It is concerned with the distribution obeyed by the extremes of datasets, e.g. the 100 values obtained by considering the largest daily temperature recorded in each of the years of a century. However, the pioneering work from the 1920s on which EVT originally built was based on independent identically distributed samples, and took no account of memory and correlation that characterise many natural hazard time series. Ignoring this would fundamentally limit our ability to forecast; so much subsequent activity has been devoted to extending EVT to encompass dependence. A second group of approaches, by contrast, has notions of time and thus possible non

  9. PROPERTIES OF THE COMPACT H II REGION COMPLEX G-0.02-0.07

    International Nuclear Information System (INIS)

    Mills, E.; Morris, M. R.; Lang, C. C.; Dong, H.; Wang, Q. D.; Cotera, A.; Stolovy, S. R.

    2011-01-01

    We present new extinction maps and high-resolution Paschen-alpha images of G-0.02-0.07, a complex of compact H II regions located adjacent to the M-0.02-0.07 giant molecular cloud, 6 pc in projection from the center of the Galaxy. These H II regions, which lie in projection just outside the boundary of the Sgr A East supernova remnant, represent one of the most recent episodes of star formation in the central parsecs of the Galaxy. The 1.87 μm extinctions of regions A, B, and C are almost identical, approximately 3.7 mag. Region D, in contrast, has a peak extinction of A 1.87 = 5.9 mag. Adopting an extinction law specific to the Galactic center, we find that these extinctions correspond to visual extinctions of A V = 45 and A V = 71. The similar and uniform extinctions of regions A, B, and C are consistent with that expected for foreground extinction in the direction of the Galactic center, suggesting that they lie at the front side of the M-0.02-0.07 molecular cloud. Region D is more compact, has a higher extinction, and is thus suspected to be younger and embedded in a dense core in a compressed ridge on the western edge of this cloud.

  10. Towards a regional ontology of management education in Africa: A complexity leadership theory perspective

    Directory of Open Access Journals (Sweden)

    Nixon M. Ochara

    2017-02-01

    Full Text Available Orientation: The title of this critique, ‘Towards a regional ontology of management education in Africa: A complexity leadership theory perspective’, sought to capture a paradox in the prescriptive nature and universalistic leaning of current leadership theories; yet local realities may call for being cognisant of (possible extant regional ontologies. Motivation for the study: The argumentation and analysis developed in this article were based on a synthesis of ideas from literature to evolve a preliminary regional ontology for reorienting business and management education relevant for Africa. Research design, approach and method: The critique was structured on insights from complexity leadership theory. The outcome was a proposition for an Afrocentric regional ontology for strengthening business and management education anchored on four themes: ethical and moral engagement, entrepreneurial leadership, Ubuntu and local National Systems of Innovation (NSI. These emerging ideas were considered to be tentative and should be considered as a foundation to inform further inquiry into how business and management education in Africa can be better interpreted and legitimised in the behavioural sciences. Practical/managerial implications: From an Afrocentric perspective, conceptualising and maintaining the logic of leadership was considered to be desirable and imperative in evolving a regional ontology of leadership that takes into account local realities. Of course, we recognised that these defining rationalities are not unique to Africa, but that said; a regional perspective that is unique cannot continue to be ignored but should find their place in discourses about leadership in the 21st century. Contribution/value-add: The synthesis and narrative presented in this paper concisely summarises and provides traction on how to advance business and management education in Africa.

  11. Personnel dosimetry of extremities by using Harshaw rings XD-100 at Centro Regional de Ciencias Nucleares, CRCN, Brazilian CNEN

    International Nuclear Information System (INIS)

    Lima, Ricardo de Andrade; Vilela, Eudice; Nogueira, Maria do Socorro; Ferreira Filho, Alfredo Lopes; Castro, Walber Amorim

    2000-01-01

    Data concerning calibration and type tests of an extremity system based on XD100 rings (Harshaw) are presented. Dosemeter used is a thermoluminescent chip inserted in a sealed pouch and was read out using a Harshaw 6600 reader. The dosimetric system complied with all ISO/DIS 12794-1 draft report suggested tests, in which this work was based on. This work obtained results point to the applicability of those recommendations to Brazilian institutes and suggest its adoption by the national regulatory commission. (author)

  12. The structure of long tubular bones fractures of lower extremity by the data of the regional bureau of forensic-medical examination

    Directory of Open Access Journals (Sweden)

    Savka I.H.

    2013-10-01

    Full Text Available The main purpose of the research is carrying out forensic-medical analysis of cases from expert’s practice with fractures of the long bones based on the findings of the Regional Bureau of Forensic-Medical Examination over 2009-2012 years period. The research has been carried out using methods of statistical and comparative analysis. Their distribution by gender, age, localization, character and type of external influence, the conditions of their occurrence and participation of other persons has been outlined. Fractures of lower extremity bones make up from 15,8 to 22,5% of all the cases of mechanical trauma with lethal outcomes. Therewith male persons suffer more often from injury of the left extremity at different day time and season. The principal mechanism of their origin is injury resulting from road accidents in the countryside with the participation of other persons.

  13. Potential changes in the extreme climate conditions at the regional scale: from observed data to modelling approaches and towards probabilistic climate change information

    International Nuclear Information System (INIS)

    Gachon, P.; Radojevic, M.; Harding, A.; Saad, C.; Nguyen, V.T.V.

    2008-01-01

    The changes in the characteristics of extreme climate conditions are one of the most critical challenges for all ecosystems, human being and infrastructure, in the context of the on-going global climate change. However, extremes information needed for impacts studies cannot be obtained directly from coarse scale global climate models (GCMs), due mainly to their difficulties to incorporate regional scale feedbacks and processes responsible in part for the occurrence, intensity and duration of extreme events. Downscaling approaches, namely statistical and dynamical downscaling techniques (i.e. SD and RCM), have emerged as useful tools to develop high resolution climate change information, in particular for extremes, as those are theoretically more capable to take into account regional/local forcings and their feedbacks from large scale influences as they are driven with GCM synoptic variables. Nevertheless, in spite of the potential added values from downscaling methods (statistical and dynamical), a rigorous assessment of these methods are needed as inherent difficulties to simulate extremes are still present. In this paper, different series of RCM and SD simulations using three different GCMs are presented and evaluated with respect to observed values over the current period and over a river basin in southern Quebec, with future ensemble runs, i.e. centered over 2050s (i.e. 2041-2070 period using the SRES A2 emission scenario). Results suggest that the downscaling performance over the baseline period significantly varies between the two downscaling techniques and over various seasons with more regular reliable simulated values with SD technique for temperature than for RCM runs, while both approaches produced quite similar temperature changes in the future from median values with more divergence for extremes. For precipitation, less accurate information is obtained compared to observed data, and with more differences among models with higher uncertainties in the

  14. A robust and efficient finite volume scheme for the discretization of diffusive flux on extremely skewed meshes in complex geometries

    Science.gov (United States)

    Traoré, Philippe; Ahipo, Yves Marcel; Louste, Christophe

    2009-08-01

    In this paper an improved finite volume scheme to discretize diffusive flux on a non-orthogonal mesh is proposed. This approach, based on an iterative technique initially suggested by Khosla [P.K. Khosla, S.G. Rubin, A diagonally dominant second-order accurate implicit scheme, Computers and Fluids 2 (1974) 207-209] and known as deferred correction, has been intensively utilized by Muzaferija [S. Muzaferija, Adaptative finite volume method for flow prediction using unstructured meshes and multigrid approach, Ph.D. Thesis, Imperial College, 1994] and later Fergizer and Peric [J.H. Fergizer, M. Peric, Computational Methods for Fluid Dynamics, Springer, 2002] to deal with the non-orthogonality of the control volumes. Using a more suitable decomposition of the normal gradient, our scheme gives accurate solutions in geometries where the basic idea of Muzaferija fails. First the performances of both schemes are compared for a Poisson problem solved in quadrangular domains where control volumes are increasingly skewed in order to test their robustness and efficiency. It is shown that convergence properties and the accuracy order of the solution are not degraded even on extremely skewed mesh. Next, the very stable behavior of the method is successfully demonstrated on a randomly distorted grid as well as on an anisotropically distorted one. Finally we compare the solution obtained for quadrilateral control volumes to the ones obtained with a finite element code and with an unstructured version of our finite volume code for triangular control volumes. No differences can be observed between the different solutions, which demonstrates the effectiveness of our approach.

  15. ARkStorm@Tahoe: Stakeholder perspectives on vulnerabilities and preparedness for an extreme storm event in the greater Lake Tahoe, Reno, and Carson City region

    Science.gov (United States)

    Albano, Christine M.; Cox, Dale A.; Dettinger, Michael; Shaller, Kevin; Welborn, Toby L.; McCarthy, Maureen

    2014-01-01

    Atmospheric rivers (ARs) are strongly linked to extreme winter precipitation events in the Western U.S., accounting for 80 percent of extreme floods in the Sierra Nevada and surrounding lowlands. In 2010, the U.S. Geological Survey developed the ARkStorm extreme storm scenario for California to quantify risks from extreme winter storms and to allow stakeholders to better explore and mitigate potential impacts. To explore impacts on natural resources and communities in montane and adjacent environments, we downscaled the scenario to the greater Lake Tahoe, Reno and Carson City region of northern Nevada and California. This ArkStorm@Tahoe scenario was presented at six stakeholder meetings, each with a different geographic and subject matter focus. Discussions were facilitated by the ARkStorm@Tahoe team to identify social and ecological vulnerabilities to extreme winter storms, science and information needs, and proactive measures that might minimize impacts from this type of event. Information collected in these meetings was used to develop a tabletop emergency response exercise and set of recommendations for increasing resilience to extreme winter storm events in both Tahoe and the downstream communities of Northern Nevada.Over 300 individuals participated in ARkStorm@Tahoe stakeholder meetings and the emergency response exercise, including representatives from emergency response, natural resource and ecosystem management, health and human services, public utilities, and businesses. Interruption of transportation, communications, and lack of power and backup fuel supplies were identified as the most likely and primary points of failure across multiple sectors and geographies, as these interruptions have cascading effects on natural and human systems by impeding emergency response efforts. Other key issues that arose in discussions included contamination risks to water supplies and aquatic ecosystems, especially in the Tahoe Basin and Pyramid Lake, interagency

  16. Complex emergencies in the Eastern Mediterranean Region: Impact on tuberculosis control.

    Science.gov (United States)

    Seita, Akihiro

    2016-12-01

    The Eastern Mediterranean Region (EMR) has witnessed the largest refugee crisis in history. Overall, 70% of the global refugee populations are from Palestine, Syria, Afghanistan, or Somalia. We reviewed the possible impact of such crisis on the tuberculosis situation in EMR. We used the available data and information from the World Health Organization and other international and national institutions. Overall, 15 out of 22 countries in the EMR are either engulfed in complex emergencies (10 countries) or suffering from their neighbors' complex emergencies (7 countries), whereas two countries suffer from both. Eighty-five percent of the total population (636 million) in the region lives in these 15 countries. For tuberculosis, these 15 countries account for a significant burden in EMR: 94% of the estimated total incidence of 740,000 cases a year and 95% of the estimated total mortality of 91,000 a year. These countries have yet to show the significant negative impact on tuberculosis epidemiology as such changes take considerable time to manifest. Still, there are reports on health systems impact: access to health facilities, destruction of health facilities, health staff casualties, and shortage of medicines. Complex emergencies pose a significant negative impact on tuberculosis in the EMR. This issue should be raised in the global health and political arena. This is a time bomb for tuberculosis. Copyright © 2016.

  17. Brazilian Policy and the Creation of a Regional Security Complex in the South Atlantic: Pax Brasiliana?

    Directory of Open Access Journals (Sweden)

    Beatriz Rodrigues Bessa Mattos

    Full Text Available Abstract Over the past five years, the South Atlantic region has become a central element of Brazilian security policy, with Brazil actively supporting the notion of a trans-oceanic security consciousness involving African littoral states. It has invested in diplomatic initiatives such as the Zone of Peace and Cooperation of the South Atlantic (ZPCSA, or ZOPACAS, and extensive military co-operation with West African states such as São Tomé e Príncipe, Namibia and Cape Verde. Its internal security and defence policy documents have repeatedly been updated to reflect this dimension, and now provide the foundation for advancing these initiatives. This policy thrust is directed at securing Brazil’s offshore oil assets, and limiting the influence of what it has termed ‘extra-regional powers’ such as the P-5. This article highlights these initiatives and reviews the prospects for this policy by examining the plausibility of the South Atlantic region as a regional security complex in the sense coined by Buzan and Wæver. The analysis is based on the role of geographical and linguistic proximity in international relations, and the impact of multilateral bodies on building support for a regional approach to security governance.

  18. Pinning-controlled synchronization of complex networks with bounded or unbounded synchronized regions

    International Nuclear Information System (INIS)

    Yan-Li, Zou; Guan-Rong, Chen

    2009-01-01

    This paper studies pinning-controlled synchronization of complex networks with bounded or unbounded synchronized regions. To study a state-feedback pinning-controlled network with N nodes, it first converts the controlled network to an extended network of N+1 nodes without controls. It is shown that the controlled synchronizability of the given network is determined by the real part of the smallest nonzero eigenvalue of the coupling matrix of its extended network when the synchronized region is unbounded; but it is determined by the ratio of the real parts of the largest and the smallest nonzero eigenvalues of the coupling matrix when the synchronized region is bounded. Both theoretical analysis and numerical simulation show that the portion of controlled nodes has no critical values when the synchronized region is unbounded, but it has a critical value when the synchronized region is bounded. In the former case, therefore, it is possible to control the network to achieve synchronization by pinning only one node. In the latter case, the network can achieve controlled synchronization only when the portion of controlled nodes is larger than the critical value. (general)

  19. Regional Risk Assessment for the analysis of the risks related to storm surge extreme events in the coastal area of the North Adriatic Sea.

    Science.gov (United States)

    Rizzi, Jonathan; Torresan, Silvia; Gallina, Valentina; Critto, Andrea; Marcomini, Antonio

    2013-04-01

    Europe's coast faces a variety of climate change threats from extreme high tides, storm surges and rising sea levels. In particular, it is very likely that mean sea level rise will contribute to upward trends in extreme coastal high water levels, thus posing higher risks to coastal locations currently experiencing coastal erosion and inundation processes. In 2007 the European Commission approved the Flood Directive (2007/60/EC), which has the main purpose to establish a framework for the assessment and management of flood risks for inland and coastal areas, thus reducing the adverse consequences for human health, the environment, cultural heritage and economic activities. Improvements in scientific understanding are thus needed to inform decision-making about the best strategies for mitigating and managing storm surge risks in coastal areas. The CLIMDAT project is aimed at improving the understanding of the risks related to extreme storm surge events in the coastal area of the North Adriatic Sea (Italy), considering potential climate change scenarios. The project implements a Regional Risk Assessment (RRA) methodology developed in the FP7 KULTURisk project for the assessment of physical/environmental impacts posed by flood hazards and employs the DEcision support SYstem for Coastal climate change impact assessment (DESYCO) for the application of the methodology to the case study area. The proposed RRA methodology is aimed at the identification and prioritization of targets and areas at risk from water-related natural hazards in the considered region at the meso-scale. To this aim, it integrates information about extreme storm surges with bio-geophysical and socio-economic information (e.g. vegetation cover, slope, soil type, population density) of the analyzed receptors (i.e. people, economic activities, cultural heritages, natural and semi-natural systems). Extreme storm surge hazard scenarios are defined using tide gauge time series coming from 28 tide gauge

  20. Regional Projections of Extreme Apparent Temperature Days in Africa and the Related Potential Risk to Human Health

    CSIR Research Space (South Africa)

    Garland, Rebecca M

    2015-10-01

    Full Text Available Regional climate modelling was used to produce high resolution climate projections for Africa, under a “business as usual scenario”, that were translated into potential health impacts utilizing a heat index that relates apparent temperature...

  1. Differential response of vegetation in Hulun Lake region at the northern margin of Asian summer monsoon to extreme cold events of the last deglaciation

    Science.gov (United States)

    Zhang, Shengrui; Xiao, Jule; Xu, Qinghai; Wen, Ruilin; Fan, Jiawei; Huang, Yun; Yamagata, Hideki

    2018-06-01

    The response of vegetation to extreme cold events during the last deglaciation is important for assessing the impact of possible extreme climatic events on terrestrial ecosystems under future global warming scenarios. Here, we present a detailed record of the development of regional vegetation in the northern margin of Asian summer monsoon during the last deglaciation (16,500-11,000 cal yr BP) based on a radiocarbon-dated high-resolution pollen record from Hulun Lake, northeast China. The results show that the regional vegetation changed from subalpine meadow-desert steppe to mixed coniferous and deciduous forest-typical steppe during the last deglaciation. However, its responses to the Heinrich event 1 (H1) and the Younger Dryas event (YD) were significantly different: during the H1 event, scattered sparse forest was present in the surrounding mountains, while within the lake catchment the vegetation cover was poor and was dominated by desert steppe. In contrast, during the YD event, deciduous forest developed and the proportion of coniferous forest increased in the mountains, the lake catchment was occupied by typical steppe. We suggest that changes in Northern Hemisphere summer insolation and land surface conditions (ice sheets and sea level) caused temperature and monsoonal precipitation variations that contributed to the contrasting vegetation response during the two cold events. We conclude that under future global warming scenarios, extreme climatic events may cause a deterioration of the ecological environment of the Hulun Lake region, resulting in increased coniferous forest and decreased total forest cover in the surrounding mountains, and a reduction in typical steppe in the lake catchment.

  2. Segmental Duplication, Microinversion, and Gene Loss Associated with a Complex Inversion Breakpoint Region in Drosophila

    Science.gov (United States)

    Calvete, Oriol; González, Josefa; Betrán, Esther; Ruiz, Alfredo

    2012-01-01

    Chromosomal inversions are usually portrayed as simple two-breakpoint rearrangements changing gene order but not gene number or structure. However, increasing evidence suggests that inversion breakpoints may often have a complex structure and entail gene duplications with potential functional consequences. Here, we used a combination of different techniques to investigate the breakpoint structure and the functional consequences of a complex rearrangement fixed in Drosophila buzzatii and comprising two tandemly arranged inversions sharing the middle breakpoint: 2m and 2n. By comparing the sequence in the breakpoint regions between D. buzzatii (inverted chromosome) and D. mojavensis (noninverted chromosome), we corroborate the breakpoint reuse at the molecular level and infer that inversion 2m was associated with a duplication of a ∼13 kb segment and likely generated by staggered breaks plus repair by nonhomologous end joining. The duplicated segment contained the gene CG4673, involved in nuclear transport, and its two nested genes CG5071 and CG5079. Interestingly, we found that other than the inversion and the associated duplication, both breakpoints suffered additional rearrangements, that is, the proximal breakpoint experienced a microinversion event associated at both ends with a 121-bp long duplication that contains a promoter. As a consequence of all these different rearrangements, CG5079 has been lost from the genome, CG5071 is now a single copy nonnested gene, and CG4673 has a transcript ∼9 kb shorter and seems to have acquired a more complex gene regulation. Our results illustrate the complex effects of chromosomal rearrangements and highlight the need of complementing genomic approaches with detailed sequence-level and functional analyses of breakpoint regions if we are to fully understand genome structure, function, and evolutionary dynamics. PMID:22328714

  3. Inflammatory arthritis mimicking Complex Regional Pain Syndrome (CRPS) in a child: A case report.

    Science.gov (United States)

    Egilmez, Zeliha; Turgut, Selin Turan; Icagasioglu, Afitap; Bicakci, Irem

    2016-01-01

    Joint complaints in childhood are seen frequently and differential diagnosis can be difficult. Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood. It involves peripheral joint arthritis, chronic synovitis, and extra-articular manifestations. Accurate diagnosis can take a long time and sometimes multiple diagnoses are used while following the patient until a final diagnosis can be reached. Arthritis may be triggered by trauma and confused with other diseases like complex regional pain syndrome (CRPS), in which trauma plays a role in the etiology. In the present case, ankle pain in an 8-year-old girl was misdiagnosed as CRPS.

  4. Clinical features and pathophysiology of Complex Regional Pain Syndrome – current state of the art

    Science.gov (United States)

    Marinus, Johan; Moseley, G. Lorimer; Birklein, Frank; Baron, Ralf; Maihöfner, Christian; Kingery, Wade S.; van Hilten, Jacobus J.

    2017-01-01

    That a minor injury can trigger a complex regional pain syndrome (CRPS) - multiple system dysfunction, severe and often chronic pain and disability - has fascinated scientists and perplexed clinicians for decades. However, substantial advances across several medical disciplines have recently increased our understanding of CRPS. Compelling evidence implicates biological pathways that underlie aberrant inflammation, vasomotor dysfunction, and maladaptive neuroplasticity in the clinical features of CRPS. Collectively, the evidence points to CRPS being a multifactorial disorder that is associated with an aberrant host response to tissue injury. Varying susceptibility to perturbed regulation of any of the underlying biological pathways probably accounts for the clinical heterogeneity of CRPS. PMID:21683929

  5. Radiofrequency ablation of stellate ganglion in a patient with complex regional pain syndrome

    Directory of Open Access Journals (Sweden)

    Chinmoy Roy

    2014-01-01

    Full Text Available Complex regional pain syndrome (CRPS is characterized by a combination of sensory, motor, vasomotor, pseudomotor dysfunctions and trophic signs. We describe the use of radiofrequency (RF ablation of Stellate ganglion (SG under fluoroscopy, for long-term suppression of sympathetic nervous system, in a patient having CRPS-not otherwise specified. Although the effects of thermal RF neurolysis may be partial or temporary, they may promote better conditions toward rehabilitation. The beneficial effect obtained by the RF neurolysis of SG in this particular patient strongly advocates the use of this mode of therapy in patients with CRPS.

  6. Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN).

    Science.gov (United States)

    Chopra, Pradeep; Cooper, Mark S

    2013-06-01

    Complex Regional Pain Syndrome (CRPS) is a neuropathic pain syndrome, which involves glial activation and central sensitization in the central nervous system. Here, we describe positive outcomes of two CRPS patients, after they were treated with low-dose naltrexone (a glial attenuator), in combination with other CRPS therapies. Prominent CRPS symptoms remitted in these two patients, including dystonic spasms and fixed dystonia (respectively), following treatment with low-dose naltrexone (LDN). LDN, which is known to antagonize the Toll-like Receptor 4 pathway and attenuate activated microglia, was utilized in these patients after conventional CRPS pharmacotherapy failed to suppress their recalcitrant CRPS symptoms.

  7. Pulsed Radiofrequency Treatment of Complex Regional Pain Syndrome: A Case Series

    Directory of Open Access Journals (Sweden)

    Vlad Djuric

    2014-01-01

    Full Text Available BACKGROUND: Various forms of sympathetic chain neurolysis (sympathectomy have, at one time or another, held promise as effective treatment options for complex regional pain syndrome (CRPS. Complications, such as worsening pain and the development of new pain syndromes, have prevented sympathectomy from emerging as a standard intervention. In an effort to avoid poor outcomes associated with neurolysis, pulsed radiofrequency (PRF has been proposed as a potential treatment alternative for a number of chronic neuropathic pain states, including some forms of CRPS.

  8. Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis.

    Science.gov (United States)

    Rupasov, Andrey; Cain, Usa; Montoya, Simone; Blickman, Johan G

    2017-09-01

    This article focuses on the imaging of 5 discrete entities with a common end result of disability: posttraumatic arthritis, a common form of secondary osteoarthritis that results from a prior insult to the joint; avascular necrosis, a disease of impaired osseous blood flow, leading to cellular death and subsequent osseous collapse; septic arthritis, an infectious process leading to destructive changes within the joint; complex regional pain syndrome, a chronic limb-confined painful condition arising after injury; and cases of cancer mimicking arthritis, in which the initial findings seem to represent arthritis, despite a more insidious cause. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Synaptonemal complex aberrations in the pseudoautosomal region of X, Y chromosomes in irradiated hamsters

    Energy Technology Data Exchange (ETDEWEB)

    Allen, J.W.; Collins, B.W. [Environmental Protection Agency, Research Triangle Park, NC (United States); Poorman-Allen, P. [Wellcome Research Lab., Research Triangle Park, N.C. (United States); Sontag, M.R. [Duke Univ., Durham, NC (United States). Medical Center

    1994-05-01

    The effects of X-radiation, bleomycin and amsacrine (m-AMSA) on the meiotic chromosomes of male Armenian hamsters were determined by electron microscopic analysis of synaptonemal complex (SC) damage. Pachytene stage cells were analyzed 5 or 6 days following their treatment at putative preleptotene-leptotene stages of meiosis. Of the multiple types of SC aberrations observed to be significantly increased over control levels, lateral element breakage and synaptic anomalies were most prevalent. The focus of these studies was on the sex chromosomes which, in the Armenian hamster, reveal an unusally well-defined pseudoautosomal region. In the XY pair, radiation and chemical treatments caused certain forms of structural and synaptic anomalies which appeared to be preferentially localized to telomeric and/or crossover regions. The nature of these specific aberrations, involving breakage, bridge formation and asynapsis, is not well understood; however, their distributions are suggestive of possible relationships with sites and processes of crossing over. (author).

  10. Block-induced Complex Structures Building the Flare-productive Solar Active Region 12673

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shuhong; Zhang, Jun [CAS Key Laboratory of Solar Activity, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Zhu, Xiaoshuai [Max-Planck Institute for Solar System Research, D-37077 Göttingen (Germany); Song, Qiao, E-mail: shuhongyang@nao.cas.cn [Key Laboratory of Space Weather, National Center for Space Weather, China Meteorological Administration, Beijing 100081 (China)

    2017-11-10

    Solar active region (AR) 12673 produced 4 X-class, 27 M-class, and numerous lower-class flares during its passage across the visible solar disk in 2017 September. Our study is to answer the questions why this AR was so flare-productive and how the X9.3 flare, the largest one of the past decade, took place. We find that there was a sunspot in the initial several days, and then two bipolar regions emerged nearby it successively. Due to the standing of the pre-existing sunspot, the movement of the bipoles was blocked, while the pre-existing sunspot maintained its quasi-circular shaped umbra only with the disappearance of a part of penumbra. Thus, the bipolar patches were significantly distorted, and the opposite polarities formed two semi-circular shaped structures. After that, two sequences of new bipolar regions emerged within the narrow semi-circular zone, and the bipolar patches separated along the curved channel. The new bipoles sheared and interacted with the previous ones, forming a complex topological system, during which numerous flares occurred. At the highly sheared region, a great deal of free energy was accumulated. On September 6, one negative patch near the polarity inversion line began to rapidly rotate and shear with the surrounding positive fields, and consequently the X9.3 flare erupted. Our results reveal that the block-induced complex structures built the flare-productive AR and the X9.3 flare was triggered by an erupting filament due to the kink instability. To better illustrate this process, a block-induced eruption model is proposed for the first time.

  11. Impaired insula functional connectivity associated with persistent pain perception in patients with complex regional pain syndrome

    Science.gov (United States)

    Jang, Joon Hwan; Lee, Do-Hyeong; Lee, Kyung-Jun; Lee, Won Joon; Moon, Jee Youn; Kim, Yong Chul

    2017-01-01

    Given that the insula plays a contributory role in the perception of chronic pain, we examined the resting-state functional connectivity between the insular cortex and other brain regions to investigate neural underpinnings of persisting perception of background pain in patients with complex regional pain syndrome (CRPS). A total of 25 patients with CRPS and 25 matched healthy controls underwent functional magnetic resonance imaging at rest. With the anterior and posterior insular cortices as seed regions, we compared the strength of the resting-state functional connectivity between the two groups. Functional connectivity between the anterior and posterior insular cortices and the postcentral and inferior frontal gyri, cingulate cortices was reduced in patients with CRPS compared with controls. Additionally, greater reductions in functional connectivity between the anterior insula and right postcentral gyrus were associated with more severe sensory pain in patients with CRPS (short-form McGill Pain Questionnaire sensory subscores, r = -.517, P = .023). The present results imply a possible role of the insula in aberrant processing of pain information in patients with CRPS. The findings suggest that a functional derangement of the connection between one of the somatosensory cortical functions of perception and one of the insular functions of awareness can play a significant role in the persistent experience of regional pain that is not confined to a specific nerve territory. PMID:28692702

  12. Genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes

    Directory of Open Access Journals (Sweden)

    Kohane Isaac

    2005-11-01

    Full Text Available Abstract Background Recent advances in genome sequencing suggest a remarkable conservation in gene content of mammalian organisms. The similarity in gene repertoire present in different organisms has increased interest in studying regulatory mechanisms of gene expression aimed at elucidating the differences in phenotypes. In particular, a proximal promoter region contains a large number of regulatory elements that control the expression of its downstream gene. Although many studies have focused on identification of these elements, a broader picture on the complexity of transcriptional regulation of different biological processes has not been addressed in mammals. The regulatory complexity may strongly correlate with gene function, as different evolutionary forces must act on the regulatory systems under different biological conditions. We investigate this hypothesis by comparing the conservation of promoters upstream of genes classified in different functional categories. Results By conducting a rank correlation analysis between functional annotation and upstream sequence alignment scores obtained by human-mouse and human-dog comparison, we found a significantly greater conservation of the upstream sequence of genes involved in development, cell communication, neural functions and signaling processes than those involved in more basic processes shared with unicellular organisms such as metabolism and ribosomal function. This observation persists after controlling for G+C content. Considering conservation as a functional signature, we hypothesize a higher density of cis-regulatory elements upstream of genes participating in complex and adaptive processes. Conclusion We identified a class of functions that are associated with either high or low promoter conservation in mammals. We detected a significant tendency that points to complex and adaptive processes were associated with higher promoter conservation, despite the fact that they have emerged

  13. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Niehof Sjoerd

    2006-11-01

    Full Text Available Abstract Background In complex regional pain syndrome type 1 (CRPS1 pro-inflammatory mediators and vascular changes play an important role in the sustained development and outcome of the disease. The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1 and nitric oxide (NO during early chronic CRPS1. Methods Included were 29 patients with CRPS 1 who were diagnosed during the acute stage of their disease and observed during follow-up visits. Disease activity and impairment were determined and artificial suction blisters were made on the CRPS1 and the contralateral extremities for measurements of IL-6, TNF-α, ET-1 and nitrate/nitrite (NOx. Results The levels of IL-6, TNF-α and ET-1 in blister fluid in the CRPS1 extremity versus the contralateral extremity were significantly increased and correlated with each other, whereas NOx levels were decreased. Conclusion The NOx/ET-1 ratio appears to be disturbed in the intermediate stage of CRPS, resulting in vasoconstriction and consequently in a diminished tissue blood distribution.

  14. Malnutrition in school children in an urban-rural region of the extreme South of São Paulo city.

    Science.gov (United States)

    Pandolfi, Marcela Maria; Sandrini, Fabio; Oliveira, Maurício Rocco de; Armond, Jane de Eston; Zöllner, Ana Cristina Ribeiro; Juliano, Yara; Souza, Patrícia Colombo de

    2011-12-01

    To evaluate the persistence of nutritional deficit in a sample of schoolchildren. A cross-sectional study of 1,761 schoolchildren between 6 and 10 years from 3 schools. They were assessed by Z scores of weight for height and height for age, according to the World Health Organization. The variables studied were gender, age, grade and school year. The χ² test was used to relate the nutritional deficit with the variables. Of all children 8.5% were malnourished according to the weight for height Z score, 21.6%, according to height for age. The analysis of the weight for height Z score revealed that 59.7% were male and 40.3% female. The mean age was 8.9 years. As to the Z score of height for age, 53.9% were males and 46.1% females. The risk of malnutrition was higher among boys: 59.7% for the weight for height index and 53.9% for height for age. There was no statistical difference between schools, gender and school year. As to nutritional status, school period (p Malnutrition still persists among the low-income population and males had a higher percentage of malnutrition. Nutritional evaluation of students is an extremely important tool for understanding the dynamics of child nutrition and development.

  15. Malnutrition in school children in an urban-rural region of the extreme South of São Paulo city

    Directory of Open Access Journals (Sweden)

    Marcela Maria Pandolfi

    2011-12-01

    Full Text Available Objective: To evaluate the persistence of nutritional deficit in a sample of schoolchildren. Methods: A cross-sectional study of 1,761 schoolchildren between 6 and 10 years from 3 schools. They were assessed by Z scores of weight for height and height for age, according to the World Health Organization. The variables studied were gender, age, grade and school year. The χ² test was used to relate the nutritional deficit with the variables. Results: Of all children 8.5% were malnourished according to the weight for height Z score, 21.6%, according to height for age. The analysis of the weight for height Z score revealed that 59.7% were male and 40.3% female. The mean age was 8.9 years. As to the Z score of height for age, 53.9% were males and 46.1% females. The risk of malnutrition was higher among boys: 59.7% for the weight for height index and 53.9% for height for age. There was no statistical difference between schools, gender and school year. As to nutritional status, school period (p < 0.0001 and students’ grade (p = 0.0105, we observed statistical significance. Conclusion: Malnutrition still persists among the low-income population and males had a higher percentage of malnutrition. Nutritional evaluation of students is an extremely important tool for understanding the dynamics of child nutrition and development.

  16. Fear of pain in children and adolescents with neuropathic pain and complex regional pain syndrome.

    Science.gov (United States)

    Simons, Laura E

    2016-02-01

    A significant proportion of children and adolescents with chronic pain endorse elevated pain-related fear. Pain-related fear is associated with high levels of disability, depressive symptoms, and school impairment. Because of faulty nerve signaling, individuals with neuropathic pain and complex regional pain syndrome may be more prone to develop pain-related fear as they avoid use of and neglect the affected body area(s), resulting in exacerbated symptoms, muscle atrophy, maintenance of pain signaling, and ongoing pain-related disability. Not surprisingly, effective treatments for elevated pain-related fears involve exposure to previously avoided activities to downregulate incorrect pain signaling. In the context of intensive interdisciplinary pain treatment of youth with neuropathic pain, decreasing pain-related fear is associated with improved physical and psychological functioning, whereas high initial pain-related fear is a risk factor for less treatment responsiveness. An innovative approach to targeting pain-related fear and evidence of a neural response to treatment involving decoupling of the amygdala with key fear circuits in youth with complex regional pain syndrome suggest breakthroughs in our ability to ameliorate these issues.

  17. Evaluation of Optimized WRF Precipitation Forecast over a Complex Topography Region during Flood Season

    Directory of Open Access Journals (Sweden)

    Yuan Li

    2016-11-01

    Full Text Available In recent years, the Weather Research and Forecast (WRF model has been utilized to generate quantitative precipitation forecasts with higher spatial and temporal resolutions. However, factors including horizontal resolution, domain size, and the physical parameterization scheme have a strong impact on the dynamic downscaling ability of the WRF model. In this study, the influence of these factors has been analyzed in precipitation forecasting for the Xijiang Basin, southern China—a region with complex topography. The results indicate that higher horizontal resolutions always result in higher Critical Success Indexes (CSI, but higher biases as well. Meanwhile, the precipitation forecast skills are also influenced by the combination of microphysics parameterization scheme and cumulus convective parameterization scheme. On the basis of these results, an optimized configuration of the WRF model is built in which the horizontal resolution is 10 km, the microphysics parameterization is the Lin scheme, and the cumulus convective parameterization is the Betts–Miller–Janjic scheme. This configuration is then evaluated by simulating the daily weather during the 2013–2014 flood season. The high Critical Success Index scores and low biases at various thresholds and lead times confirm the high accuracy of the optimized WRF model configuration for Xijiang Basin. However, the performance of the WRF model varies from different sub-basins due to the complexity of the mesoscale convective system (MCS over this region.

  18. Path Complexity in Virtual Water Maze Navigation: Differential Associations with Age, Sex, and Regional Brain Volume.

    Science.gov (United States)

    Daugherty, Ana M; Yuan, Peng; Dahle, Cheryl L; Bender, Andrew R; Yang, Yiqin; Raz, Naftali

    2015-09-01

    Studies of human navigation in virtual maze environments have consistently linked advanced age with greater distance traveled between the start and the goal and longer duration of the search. Observations of search path geometry suggest that routes taken by older adults may be unnecessarily complex and that excessive path complexity may be an indicator of cognitive difficulties experienced by older navigators. In a sample of healthy adults, we quantify search path complexity in a virtual Morris water maze with a novel method based on fractal dimensionality. In a two-level hierarchical linear model, we estimated improvement in navigation performance across trials by a decline in route length, shortening of search time, and reduction in fractal dimensionality of the path. While replicating commonly reported age and sex differences in time and distance indices, a reduction in fractal dimension of the path accounted for improvement across trials, independent of age or sex. The volumes of brain regions associated with the establishment of cognitive maps (parahippocampal gyrus and hippocampus) were related to path dimensionality, but not to the total distance and time. Thus, fractal dimensionality of a navigational path may present a useful complementary method of quantifying performance in navigation. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Complex pegmatite - apelitic of Cabecinha - strategies appreciation of geological heritage and economic development of the region

    Science.gov (United States)

    Nobre, José; Cabral, Tiago; Cabral, João; Gomes, Ana

    2014-05-01

    The Complex pegmatite - apelitic of Cabecinha corresponds to an isolated ridge that reaches 933 meters, located in the middle zone of transition between the Hesperian massif and the Cova da Beira being located in the NE central part of Portugal, more specifically in the Mountainous region of the province of Beira Alta, council of Sabugal. This complex lies embedded in porphyritic granites with terms of switching to a medium-grained granite rich in sodium feldspars in which they are muscovite granite intrusions. The lodes have pegmatites with NE-SW orientation, presenting phases of predominantly quartz crystallization with multiple parageneses. The inclusions observed are veins filonianian secondary. Some veins have structural discontinuity due to further their training tectonics. The apelitico material is basic in nature engaging in descontinuiddes of pegmatite material, showing no preferred orientation. The petrological characteristics of the area in question provide the appearance of motivating exotic landforms of scientific interest. These landforms, over time, have motivated the popular level the emergence of various myths, thus contributing to the enrichment of the local cultural heritage. This study proceeded to the geological and geomorphological mapping an area of about 6945,350 m2 with a maximum length of 182 m. The huge patent mineralogical, petrological and geomorphological level geodiversity, allied to the structural complexity and associated cultural heritage, allow geoconservation strategies and recovery, using new multimedia technologies including use of QR codes and 3D. All this geological framework and environment becomes an asset for the scientific, educational and economic development of the region. On the other hand, it has the vital Importance in the context of the strategy of forming a geological park, in the point of view of tourism, research and interpretation.

  20. Energy and carbon emissions analysis and prediction of complex petrochemical systems based on an improved extreme learning machine integrated interpretative structural model

    International Nuclear Information System (INIS)

    Han, Yongming; Zhu, Qunxiong; Geng, Zhiqiang; Xu, Yuan

    2017-01-01

    Highlights: • The ELM integrated ISM (ISM-ELM) method is proposed. • The proposed method is more efficient and accurate than the ELM through the UCI data set. • Energy and carbon emissions analysis and prediction of petrochemical industries based ISM-ELM is obtained. • The proposed method is valid in improving energy efficiency and reducing carbon emissions of ethylene plants. - Abstract: Energy saving and carbon emissions reduction of the petrochemical industry are affected by many factors. Thus, it is difficult to analyze and optimize the energy of complex petrochemical systems accurately. This paper proposes an energy and carbon emissions analysis and prediction approach based on an improved extreme learning machine (ELM) integrated interpretative structural model (ISM) (ISM-ELM). ISM based the partial correlation coefficient is utilized to analyze key parameters that affect the energy and carbon emissions of the complex petrochemical system, and can denoise and reduce dimensions of data to decrease the training time and errors of the ELM prediction model. Meanwhile, in terms of the model accuracy and the training time, the robustness and effectiveness of the ISM-ELM model are better than the ELM through standard data sets from the University of California Irvine (UCI) repository. Moreover, a multi-inputs and single-output (MISO) model of energy and carbon emissions of complex ethylene systems is established based on the ISM-ELM. Finally, detailed analyses and simulations using the real ethylene plant data demonstrate the effectiveness of the ISM-ELM and can guide the improvement direction of energy saving and carbon emissions reduction in complex petrochemical systems.

  1. Lack of genetic association of neutral endopeptidase (NEP) with complex regional pain syndrome (CRPS).

    Science.gov (United States)

    Huehne, Kathrin; Schaal, Ute; Leis, Stefan; Uebe, Steffen; Gosso, M Florencia; van den Maagdenberg, Arn M J M; Maihöfner, Christian; Birklein, Frank; Rautenstrauss, Bernd; Winterpacht, Andreas

    2010-03-12

    Complex regional pain syndrome (CRPS) is a condition that is characterized by severe pain and exaggerated neurogenic inflammation, which may develop after injury or surgery. Neurogenic inflammation is mediated by neuropeptides, such as calcitonin gene-related peptide (CGRP) and substance P (SP) that are released from nociceptors. Genetic factors may play a role in CRPS as was suggested by the occurrence of familial cases and several genetic association studies investigating mainly the human leukocyte antigen (HLA) system. Here we investigated the role of neutral endopeptidase (NEP), a key enzyme in neuropeptide catabolism. NEP dysfunction resulting in reduced inactivation of neuropeptides may be a possible pathomechanism in CRPS. To this end, we tested a GT-repeat polymorphism in the NEP promoter region as well as 18 tag-SNPs in six linkage disequilibrium (LD) blocks in the NEP gene region in 320 CRPS patients and 376 controls. No significant genetic association was observed. Thus, we conclude that the NEP gene does not seem to be a major risk factor for CRPS. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  2. Central Asia as a Regional Security Complex from the Perspectives of Realism, Liberalism and Constructivism

    Directory of Open Access Journals (Sweden)

    Caroline Putri Pratama

    2013-05-01

    Full Text Available Tulisan ini bertujuan menganalisis kawasan Asia Tengah, dilihat dari perspektif Realisme, Liberalisme dan Konstruktivisme, melalui teori Regional Security Complex oleh Barry Buzan dan Ole Waever. Teori ini hendak menunjukkan keamanan regional berdasarkan interdependensi antar unit dalam kawasan dilihat dari struktur power dan proses sekuritisasi di dalamnya, demikian pola hubungan keamanan dalam kawasan Asia Tengah berusaha dijelaskan dengan elemen-elemen dari ketiga paradigma yang terdapat dalam teori tersebut. Hasil analisis tulisan ini menunjukkan bahwa Asia Tengah dipandang sebagai bentuk insecurity interdependence by external forces dari perspektif Realis, security interdependence by interest dari perspektif Liberalis dan securitization interdependence by understanding of threat/security dari perspektif Konstruktivis. Kompleks keamanan Asia Tengah termasuk dalam tipe kompleks keamanan Great Power, terlihat dari peran besar kekuatan-kekuatan eksternal terutama Rusia dan Cina dalam kawasan tersebut; baik dalam pembentukan pola pertemanan dengan kerjasama, pola permusuhan dengan persaingan dan ketakutan, juga proses sekuritisasi isu separatisme, ekstremisme dan terorisme sebagai ancaman terhadap keamanan regional.Tulisan ini diambil dari tugas karya akhir penulis yang diajukan untuk medapatkan gelar Sarjana Sosial dari Departemen Ilmu Hubungan Internasional, Universitas Indonesia.

  3. Assessment of ENSEMBLES regional climate models for the representation of monthly wind characteristics in the Aegean Sea (Greece): Mean and extremes analysis

    Science.gov (United States)

    Anagnostopoulou, Christina; Tolika, Konstantia; Tegoulias, Ioannis; Velikou, Kondylia; Vagenas, Christos

    2013-04-01

    The main scope of the present study is the assessment of the ability of three of the most updated regional climate models, developed under the frame of the European research project ENSEMBLES (http://www.ensembles-eu.org/), to simulate the wind characteristics in the Aegean Sea in Greece. The examined models are KNMI-RACMO2, MPI-MREMO, and ICTP - RegCM3. They all have the same spatial resolution (25x25km) and for their future projections they are using the A1B SRES emission scenarios. Their simulated wind data (speed and direction) were compared with observational data from several stations over the domain of study for a time period of 25 years, from 1980 to 2004 on a monthly basis. The primer data were available every three or six hours from which we computed the mean daily wind speed and the prevailing daily wind direction. It should be mentioned, that the comparison was made for the grid point that was the closest to each station over land. Moreover, the extreme speed values were also calculated both for the observational and the simulated data, in order to assess the ability of the models in capturing the most intense wind conditions. The first results of the study showed that the prevailing winds during the winter and spring months have a north - northeastern or a south - south western direction in most parts of the Aegean sea. The models under examination seem to capture quite satisfactorily this pattern as well as the general characteristics of the winds in this area. During summer, winds in the Aegean Sea have mainly north direction and the models have quite good agreement both in simulating this direction and the wind speed. Concerning the extreme wind speed (percentiles) it was found that for the stations in the northern Aegean all the models overestimate the extreme wind indices. For the eastern parts of the Aegean the KNMI and the MPI model underestimate the extreme wind speeds while on the other hand the ICTP model overestimates them. Finally for the

  4. Optimization with Extremal Dynamics

    International Nuclear Information System (INIS)

    Boettcher, Stefan; Percus, Allon G.

    2001-01-01

    We explore a new general-purpose heuristic for finding high-quality solutions to hard discrete optimization problems. The method, called extremal optimization, is inspired by self-organized criticality, a concept introduced to describe emergent complexity in physical systems. Extremal optimization successively updates extremely undesirable variables of a single suboptimal solution, assigning them new, random values. Large fluctuations ensue, efficiently exploring many local optima. We use extremal optimization to elucidate the phase transition in the 3-coloring problem, and we provide independent confirmation of previously reported extrapolations for the ground-state energy of ±J spin glasses in d=3 and 4

  5. Are you better? A multi-centre study of patient-defined recovery from Complex Regional Pain Syndrome

    DEFF Research Database (Denmark)

    Llewellyn, A; McCabe, CS; Hibberd, Y

    2018-01-01

    Background: Complex Regional Pain Syndrome (CRPS) symptoms can significantly differ between patients, fluctuate over time, disappear or persist. This leads to problems in defining recovery and in evaluating the efficacy of therapeutic interventions. Objectives: To define recovery from the patient...

  6. Online coupling of high-resolution chromatography with extreme UV photon activation tandem mass spectrometry: Application to the structural investigation of complex glycans by dissociative photoionization

    International Nuclear Information System (INIS)

    Ropartz, David; Giuliani, Alexandre; Fanuel, Mathieu; Hervé, Cécile; Czjzek, Mirjam; Rogniaux, Hélène

    2016-01-01

    The activation of ions by extreme-energy photons (XUV) produced by a synchrotron radiation beamline is a powerful method for characterizing complex glycans using tandem mass spectrometry (MS). As previously described, this activation method leads to rich fragmentation spectra with many structurally valuable cross-ring cleavages while maintaining labile modifications on the glycan structures. However, until now, the tandem MS event was too long to be compatible with liquid chromatography elution times. In this work, the duty cycle of the activation and detection of fragments was shortened, and the background signal on the spectra was drastically reduced. Both improvements allowed, for the first time, the successful coupling of a UHPLC system to XUV-activated tandem MS. The approach was used to characterize a complex mixture of oligo-porphyrans, which are a class of highly sulfated oligosaccharides, in a fully automated way. Due to an enhanced dynamic range and an increased sensitivity, some hypothetical structures of low abundance have been unequivocally confirmed in this study and others have been revised. Some previously undescribed species of oligo-porphyrans that exhibit lateral branching have been fully resolved. This work contributes to the scarce knowledge of the structure of porphyrans in red algae and pushes the current capacities of XUV-activation tandem MS by demonstrating the possibility of a direct coupling with UHPLC. This study will considerably broaden the applicability and practicality of this method in many fields of analytical biology. - Highlights: • For the first time, XUV photon activation tandem MS was coupled to UHPLC. • The approach was used to characterize a complex mixture of biomolecules. • The MSMS duty cycle was compatible with elution times of UHPLC without compromised. • Minor species were characterized with an enhanced sensitivity and dynamic range. • These results broaden the application of the technique in many field of

  7. Online coupling of high-resolution chromatography with extreme UV photon activation tandem mass spectrometry: Application to the structural investigation of complex glycans by dissociative photoionization

    Energy Technology Data Exchange (ETDEWEB)

    Ropartz, David, E-mail: David.Ropartz@nantes.inra.fr [INRA, UR1268 Biopolymers Interactions Assemblies F-44316 Nantes (France); Giuliani, Alexandre [Synchrotron SOLEIL, L' Orme des Merisiers, F-91190 Gif-sur-Yvette (France); UAR 1008 CEPIA, INRA, F-44316 Nantes (France); Fanuel, Mathieu [INRA, UR1268 Biopolymers Interactions Assemblies F-44316 Nantes (France); Hervé, Cécile; Czjzek, Mirjam [Sorbonne Universités, Université Pierre et Marie Curie, Paris VI, CNRS, Integrative Biology of Marine Models, UMR 8227, Station Biologique, Place George Teissier, F29688 Roscoff Cedex (France); Rogniaux, Hélène [INRA, UR1268 Biopolymers Interactions Assemblies F-44316 Nantes (France)

    2016-08-24

    The activation of ions by extreme-energy photons (XUV) produced by a synchrotron radiation beamline is a powerful method for characterizing complex glycans using tandem mass spectrometry (MS). As previously described, this activation method leads to rich fragmentation spectra with many structurally valuable cross-ring cleavages while maintaining labile modifications on the glycan structures. However, until now, the tandem MS event was too long to be compatible with liquid chromatography elution times. In this work, the duty cycle of the activation and detection of fragments was shortened, and the background signal on the spectra was drastically reduced. Both improvements allowed, for the first time, the successful coupling of a UHPLC system to XUV-activated tandem MS. The approach was used to characterize a complex mixture of oligo-porphyrans, which are a class of highly sulfated oligosaccharides, in a fully automated way. Due to an enhanced dynamic range and an increased sensitivity, some hypothetical structures of low abundance have been unequivocally confirmed in this study and others have been revised. Some previously undescribed species of oligo-porphyrans that exhibit lateral branching have been fully resolved. This work contributes to the scarce knowledge of the structure of porphyrans in red algae and pushes the current capacities of XUV-activation tandem MS by demonstrating the possibility of a direct coupling with UHPLC. This study will considerably broaden the applicability and practicality of this method in many fields of analytical biology. - Highlights: • For the first time, XUV photon activation tandem MS was coupled to UHPLC. • The approach was used to characterize a complex mixture of biomolecules. • The MSMS duty cycle was compatible with elution times of UHPLC without compromised. • Minor species were characterized with an enhanced sensitivity and dynamic range. • These results broaden the application of the technique in many field of

  8. Association of Neglect-Like Symptoms with Anxiety, Somatization, and Depersonalization in Complex Regional Pain Syndrome.

    Science.gov (United States)

    Michal, Matthias; Adler, Julia; Reiner, Iris; Wermke, Andreas; Ackermann, Tatiana; Schlereth, Tanja; Birklein, Frank

    2017-04-01

    Many patients with complex regional pain syndrome (CRPS) report some foreignness of the affected limb, which is referred to as "neglect-like symptoms" (NLS). Despite similarities of the NLS reports to symptoms of body image disturbances in mental disorders, no study has been conducted to examine such associations. We investigated 50 patients with CRPS and 45 pain control patients (N = 27, chronic limb pain; N = 18, migraine headache). NLS, anxiety, depression, depersonalization, and somatization were assessed using validated questionnaires. Seventy-two percent of the CRPS patients reported at least one NLS vs 29.6% and 33.3% in the two patient control groups. In limb pain controls, NLS correlated with pain intensity. In CRPS patients, NLS correlated with anxiety (rho = 0.658, P  psychological studies. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

  9. Complex regional pain syndrome with associated chest wall dystonia: a case report

    Directory of Open Access Journals (Sweden)

    Schwartzman Robert J

    2011-09-01

    Full Text Available Abstract Patients with complex regional pain syndrome (CRPS often suffer from an array of associated movement disorders, including dystonia of an affected limb. We present a case of a patient with long standing CRPS after a brachial plexus injury, who after displaying several features of the movement disorder previously, developed painful dystonia of chest wall musculature. Detailed neurologic examination found palpable sustained contractions of the pectoral and intercostal muscles in addition to surface allodynia. Needle electromyography of the intercostal and paraspinal muscles supported the diagnosis of dystonia. In addition, pulmonary function testing showed both restrictive and obstructive features in the absence of a clear cardiopulmonary etiology. Treatment was initiated with intrathecal baclofen and the patient had symptomatic relief and improvement of dystonia. This case illustrates a novel form of the movement disorder associated with CRPS with response to intrathecal baclofen treatment.

  10. Motor imagery and its effect on complex regional pain syndrome: an integrative review

    Directory of Open Access Journals (Sweden)

    Nélio Silva de Souza

    2015-12-01

    Full Text Available The motor imagery (MI has been proposed as a treatment in the complex regional pain syndrome type 1 (CRPS-1, since it seems to promote a brain reorganization effect on sensory- motor areas of pain perception. The aim of this paper is to investigate, through an integrative critical review, the influence of MI on the CRPS-1, correlating their evidence to clinical practice. Research in PEDro, Medline, Bireme and Google Scholar databases was conducted. Nine randomized controlled trials (level 2, 1 non-controlled clinical study (level 3, 1 case study (level 4, 1 systematic review (level 1, 2 review articles and 1 comment (level 5 were found. We can conclude that MI has shown effect in reducing pain and functionality that remains after 6 months of treatment. However, the difference between the MI strategies for CRPS-1 is unknown as well as the intensity of mental stress influences the painful response or effect of MI or other peripheral neuropathies.

  11. Molecular signature of complex regional pain syndrome (CRPS) and its analysis.

    Science.gov (United States)

    König, Simone; Schlereth, Tanja; Birklein, Frank

    2017-10-01

    Complex Regional Pain Syndrome (CRPS) is a rare, but often disabling pain disease. Biomarkers are lacking, but several inflammatory substances have been associated with the pathophysiology. This review outlines the current knowledge with respect to target biomolecules and the analytical tools available to measure them. Areas covered: Targets include cytokines, neuropeptides and resolvins; analysis strategies are thus needed for different classes of substances such as proteins, peptides, lipids and small molecules. Traditional methods like immunoassays are of importance next to state-of-the art high-resolution mass spectrometry techniques and 'omics' approaches. Expert commentary: Future biomarker studies need larger cohorts, which improve subgrouping of patients due to their presumed pathophysiology, and highly standardized workflows from sampling to analysis.

  12. Continuous Thoracic Sympathetic Ganglion Block in Complex Regional Pain Syndrome Patients with Spinal Cord Stimulation Implantation

    Directory of Open Access Journals (Sweden)

    EungDon Kim

    2016-01-01

    Full Text Available The sympathetic block is widely used for treating neuropathic pain such as complex regional pain syndrome (CRPS. However, single sympathetic block often provides only short-term effect. Moreover, frequent procedures for sympathetic block may increase the risk of complications. The use of epidural route may be limited by concern of infection in case of previous implantation of the spinal cord stimulation (SCS. In contrast, a continuous sympathetic block can be administered without such concerns. The continuous thoracic sympathetic block (TSGB has been used to treat the ischemic disease and other neuropathic conditions such as postherpetic neuralgia. We administered continuous thoracic sympathetic block using catheter in CRPS patients who underwent SCS implantations and achieved desirable outcomes. We believe a continuous sympathetic block is a considerable option before performing neurolysis or radiofrequency rhizotomy and even after SCS implantation.

  13. Complex organic molecules toward low-mass and high-mass star forming regions

    Science.gov (United States)

    Favre, C.; Ceccarelli, C.; Lefloch, B.; Bergin, E.; Carvajal, M.; Brouillet, N.; Despois, D.; Jørgensen, J.; Kleiner, I.

    2016-12-01

    One of the most important questions in molecular astrophysics is how, when, and where complex organic molecules, COMs (≥ 6 atoms) are formed. In the Interstellar-Earth connection context, could this have a bearing on the origin of life on Earth? Formation mechanisms of COMs, which include potentially prebiotic molecules, are still debated and may include grain-mantle and/or gas-phase chemistry. Understanding the mechanisms that lead to the interstellar molecular complexification, along with the involved physicochemical processes, is mandatory to answer the above questions. In that context, active researches are ongoing in theory, laboratory experiment, chemical modeling and observations. Thanks to recent progress in radioastronomy instrumentation for both single-dish and millimeter array (e.g. Herschel, NOEMA, ALMA), new results have been obtained. I will review some notable results on the detection of COMs, including prebiotic molecules, towards star forming regions.

  14. Analysing the mechanisms of soil water and vapour transport in the desert vadose zone of the extremely arid region of northern China

    Science.gov (United States)

    Du, Chaoyang; Yu, Jingjie; Wang, Ping; Zhang, Yichi

    2018-03-01

    The transport of water and vapour in the desert vadose zone plays a critical role in the overall water and energy balances of near-surface environments in arid regions. However, field measurements in extremely dry environments face many difficulties and challenges, so few studies have examined water and vapour transport processes in the desert vadose zone. The main objective of this study is to analyse the mechanisms of soil water and vapour transport in the desert vadose zone (depth of ∼350 cm) by using measured and modelled data in an extremely arid environment. The field experiments are implemented in an area of the Gobi desert in northwestern China to measure the soil properties, daily soil moisture and temperature, daily water-table depth and temperature, and daily meteorological records from DOYs (Days of Year) 114-212 in 2014 (growing season). The Hydrus-1D model, which simulates the coupled transport of water, vapour and heat in the vadose zone, is employed to simulate the layered soil moisture and temperature regimes and analyse the transport processes of soil water and vapour. The measured results show that the soil water and temperatures near the land surface have visible daily fluctuations across the entire soil profile. Thermal vapour movement is the most important component of the total water flux and the soil temperature gradient is the major driving factor that affects vapour transport in the desert vadose zone. The most active water and heat exchange occurs in the upper soil layer (depths of 0-25 cm). The matric potential change from the precipitation mainly re-draws the spatio-temporal distribution of the isothermal liquid water in the soil near the land surface. The matric potential has little effect on the isothermal vapour and thermal liquid water flux. These findings offer new insights into the liquid water and vapour movement processes in the extremely arid environment.

  15. An immunohistochemical study of the triangular fibrocartilage complex of the wrist: regional variations in cartilage phenotype

    Science.gov (United States)

    Milz, S; Sicking, B; Sprecher, C M; Putz, R; Benjamin, M

    2007-01-01

    The triangular fibrocartilage complex (TFCC) transmits load from the wrist to the ulna and stabilizes the distal radioulnar joint. Damage to it is a major cause of wrist pain. Although its basic structure is well established, little is known of its molecular composition. We have analysed the immunohistochemical labelling pattern of the extracellular matrix of the articular disc and the meniscal homologue of the TFCC in nine elderly individuals (age range 69–96 years), using a panel of monoclonal antibodies directed against collagens, glycosaminoglycans, proteoglycans and cartilage oligomeric matrix protein (COMP). Although many of the molecules (types I, III and VI collagen, chondroitin 4 sulphate, dermatan sulphate and keratan sulphate, the oversulphated epitope of chondroitin 6 sulphate, versican and COMP) were found in all parts of the TFCC, aggrecan, link protein and type II collagen were restricted to the articular disc and to entheses. They were thus not a feature of the meniscal homologue. The shift in tissue phenotype within the TFCC, from a fibrocartilaginous articular disc to a more fibrous meniscal homologue, correlates with biomechanical data suggesting that the radial region is stiff and subject to considerable stress concentration. The presence of aggrecan, link protein and type II collagen in the articular disc could explain why the TFCC is destroyed in rheumatoid arthritis, given that it has been suggested that autoimmunity to these antigens results in the destruction of articular cartilage. The differential distribution of aggrecan within the TFCC is likely to be reflected by regional differences in water content and mobility on the radial and ulnar side. This needs to be taken into account in the design of improved MRI protocols for visualizing this ulnocarpal complex of the wrist. PMID:17532798

  16. Mandelbrot's Extremism

    NARCIS (Netherlands)

    Beirlant, J.; Schoutens, W.; Segers, J.J.J.

    2004-01-01

    In the sixties Mandelbrot already showed that extreme price swings are more likely than some of us think or incorporate in our models.A modern toolbox for analyzing such rare events can be found in the field of extreme value theory.At the core of extreme value theory lies the modelling of maxima

  17. Granulitic orthogneisses geochemistry of Caraiba complex, in Riachao do Jacuipe region - Bahia state, Brazil

    International Nuclear Information System (INIS)

    Teixeira, L.R.; Mello, R.C.

    1990-01-01

    This paper describes the granulitic orthogneisses of the Riachao do Jacuipe unit (Caraiba Complex) petrographicaly classified as tonalitic (predominating), trondhjemitic, granodioritic and quartz dioritic hyperstene gneisses. The chemical composition of the orthogneisses is dominantly tonalitic/granodioritic, that is typical of a calc-alkaline parentage depleted in K and enriched in Al sub(2) O sub(3). Their geochemical characteristics are very similar to those of the grey gneisses of other regions of the world, usually named TTG (tonalite-trondhhemite-granodiorite). In the sequence of orthogneiss coexist rocks both normal and depleted in LILE. The patterns of distribution of highly fractioned REE (La/YbN ratio up to 102) with Eu anomaly small or absent points against a direct mantle origin. On the other hand the only Rb-Sr age determination in the se rocks gives an age of 2,35 Ga with an initial ratio (Ro) of 0,702. This initial ratio suggests that the rocks did not originated from reworking of a much older continental crust. The available data suggest that the granulitized orthogneisses of the Caraiba Complex were formed by partial melt of basaltic material (amphibalitized oceanic crust). (author)

  18. Stratigraphic units overlying the Zambales Ophiolite Complex (ZOC) in Luzon, (Philippines): Tectonostratigraphic significance and regional implications

    Science.gov (United States)

    Queaño, Karlo L.; Dimalanta, Carla B.; Yumul, Graciano P.; Marquez, Edanjarlo J.; Faustino-Eslava, Decibel V.; Suzuki, Shigeyuki; Ishida, Keisuke

    2017-07-01

    The Zambales Ophiolite Complex (ZOC) on the island of Luzon, Philippines is one of the most well-studied crust-mantle sequences in the region. Several massifs comprise the ZOC, one of which is the Coto Block overlain by clastic sedimentary units previously dated as Eocene. Geochronologic studies from diabase, granodiorites and other late-stage magmatic products similarly yielded the same age. Succeeding tectonic models have therefore all been grounded on the assumption that the entire ZOC is Eocene. Recent investigations, however, revealed the presence of chert blocks within the Early to Middle Miocene clastic formation overlying the Acoje Block in the northern part of the ophiolite complex. Radiolarians extracted from the cherts yielded a stratigraphic range that suggests a Late Jurassic to Early Cretaceous age. The recognition of a much older age than previously reported of the ZOC warrants a re-examination of its actual distribution and genesis. Correlating with other similarly-aged ophiolites, we suggest defining a western Mesozoic ophiolite belt, largely extending from the west-central portion of the archipelago to the northeastern tip of Luzon island. Tentatively, we attribute the Mesozoic ophiolitic and associated rocks in western Luzon to an arc-continent collision involving the Philippine Mobile Belt and the Palawan Microcontinental Block. In addition, differences in the clastic compositions of the Cenozoic sedimentary formations provide material not only for deciphering the ZOC's unroofing history but also for constraining the timing of province linkage. The intermittent appearance of lithic fragments and detrital minerals from the ophiolite in the units of the Middle Miocene Candelaria Limestone and the Late Miocene to Early Pliocene Sta. Cruz Formation indicates significant but geographically variable contributions from the ophiolite complex. In the northern Zambales Range, the Sta. Cruz Formation caps the Coto Block and the Acoje Block of the ZOC

  19. The absolute photoionization cross sections of helium, neon, argon and krypton in the extreme vacuum ultraviolet region of the spectrum

    International Nuclear Information System (INIS)

    West, J.B.; Marr, G.V.

    1976-01-01

    An experiment has been set up at the Daresbury Synchrotron Radiation Facility to make absolute absorption cross section measurements over a wide range of photon energies. New data are reported for helium, neon, argon and krypton over the range 340 to 40 A which are believed to be reliable to +- 5%. A critical evaluation of published cross section data has been carried out to produce best value data from the ionization thresholds throughout the vacuum ultraviolet and x-ray region. Agreement with theoretical calculations on helium is demonstrated to be within +- 2 to 3% from threshold down to the double ionization threshold at 79 eV. Comparison with recent calculations of photoionization cross sections has shown that the effect of electron correlations is significant for the heavier inert gases. Contrary to previous claims, the position of the M shell maximum in krypton is located at 184 +- 10 eV in good agreement with r.p.a.e. calculations. Oscillator strength sum rules have been examined and their moments calculated. Discrepancies developing towards the heavier inert gases suggests a decrease in polarizabilities and other atomic factors from those predicted by Hartree-Fock calculations. (author)

  20. Impacts of projected maximum temperature extremes for C21 by an ensemble of regional climate models on cereal cropping systems in the Iberian Peninsula

    Directory of Open Access Journals (Sweden)

    M. Ruiz-Ramos

    2011-12-01

    Full Text Available Crops growing in the Iberian Peninsula may be subjected to damagingly high temperatures during the sensitive development periods of flowering and grain filling. Such episodes are considered important hazards and farmers may take insurance to offset their impact. Increases in value and frequency of maximum temperature have been observed in the Iberian Peninsula during the 20th century, and studies on climate change indicate the possibility of further increase by the end of the 21st century. Here, impacts of current and future high temperatures on cereal cropping systems of the Iberian Peninsula are evaluated, focusing on vulnerable development periods of winter and summer crops. Climate change scenarios obtained from an ensemble of ten Regional Climate Models (multimodel ensemble combined with crop simulation models were used for this purpose and related uncertainty was estimated. Results reveal that higher extremes of maximum temperature represent a threat to summer-grown but not to winter-grown crops in the Iberian Peninsula. The study highlights the different vulnerability of crops in the two growing seasons and the need to account for changes in extreme temperatures in developing adaptations in cereal cropping systems. Finally, this work contributes to clarifying the causes of high-uncertainty impact projections from previous studies.

  1. Comparative evaluation of the IPCC AR5 CMIP5 versus the AR4 CMIP3 model ensembles for regional precipitation and their extremes over South America

    Science.gov (United States)

    Tolen, J.; Kodra, E. A.; Ganguly, A. R.

    2011-12-01

    The assertion that higher-resolution experiments or more sophisticated process models within the IPCC AR5 CMIP5 suite of global climate model ensembles improves precipitation projections over the IPCC AR4 CMIP3 suite remains a hypothesis that needs to be rigorously tested. The questions are particularly important for local to regional assessments at scales relevant for the management of critical infrastructures and key resources, particularly for the attributes of sever precipitation events, for example, the intensity, frequency and duration of extreme precipitation. Our case study is South America, where precipitation and their extremes play a central role in sustaining natural, built and human systems. To test the hypothesis that CMIP5 improves over CMIP3 in this regard, spatial and temporal measures of prediction skill are constructed and computed by comparing climate model hindcasts with the NCEP-II reanalysis data, considered here as surrogate observations, for the entire globe and for South America. In addition, gridded precipitation observations over South America based on rain gage measurements are considered. The results suggest that the utility of the next-generation of global climate models over the current generation needs to be carefully evaluated on a case-by-case basis before communicating to resource managers and policy makers.

  2. The semiquantitative three-phase bone scintigraphy on hemiplegic patients with earlier complex regional pain syndrome

    International Nuclear Information System (INIS)

    Li Fang; Liu Xingdang; Lu Zhihui; Liu Congjin

    2010-01-01

    Objective: To investigate the difference between the early phases and delay phase of three-phase bone scintigraphy on hemiplegic patients with earlier complex regional pain syndrome (CRPS). Methods: Twenty-nine stroke patients with hemiplegia complicating CRPS received three-phase bone scintigraphy after intravenous injection of 99 Tc m -methylene diphosphonate (MDP). The region of interest (ROI) technique was used to obtain the radioactive counts of involved joints and contralateral sites on wrists, metacarpophalangeal, proximal interphalangeal and distal interphalangeal joints. The total counts of these four sites in each patient were then obtained and the total uptake ratios of involved joints/contralateral joints for each phase were calculated to compare the difference among the three phases. Wilcoxon test and ANOVA were used in data analyses. Results: The involved joints of hemiplegic side displayed higher tracer uptake. There were significant differences of the radioactive counts between involved joints and uninvolved ones in the perfusion, pool and delay phase (Wilcoxon test, Z: -4.73 to -2.10, P<0.05). There was no significant difference of total uptake ratios of involved joints/contralateral joints among the three phases (ANOVA, F = 0. 807, P < 0.05). Conclusions: Due to higher bone seeking agent accumulation on three-phase bone scintigraphy, both early phases and delay phase imaging showed similar value in stroke patients with hemiplegia complicating earlier CRPS. (authors)

  3. A comparison of spatial interpolation methods for soil temperature over a complex topographical region

    Science.gov (United States)

    Wu, Wei; Tang, Xiao-Ping; Ma, Xue-Qing; Liu, Hong-Bin

    2016-08-01

    Soil temperature variability data provide valuable information on understanding land-surface ecosystem processes and climate change. This study developed and analyzed a spatial dataset of monthly mean soil temperature at a depth of 10 cm over a complex topographical region in southwestern China. The records were measured at 83 stations during the period of 1961-2000. Nine approaches were compared for interpolating soil temperature. The accuracy indicators were root mean square error (RMSE), modelling efficiency (ME), and coefficient of residual mass (CRM). The results indicated that thin plate spline with latitude, longitude, and elevation gave the best performance with RMSE varying between 0.425 and 0.592 °C, ME between 0.895 and 0.947, and CRM between -0.007 and 0.001. A spatial database was developed based on the best model. The dataset showed that larger seasonal changes of soil temperature were from autumn to winter over the region. The northern and eastern areas with hilly and low-middle mountains experienced larger seasonal changes.

  4. A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging

    International Nuclear Information System (INIS)

    Narra, R.K.; Nunn, A.D.; Kuczynski, B.L.; DiRocco, R.J.; Feld, T.; Silva, D.A.; Eckelman, W.C.

    1990-01-01

    Technetium-99m-DMG-2MP (Chloro[bis[2,3-butanedionedioxime(1-)-0][2,3- butanedionedioximato (2-)-N,N',N double-prime,N'double-prime,N double-prime double-prime,N'double-prime double-prime] (2-methylpropyl borato (2-))technetium]), also known as SQ 32097 is a member of a family of neutral lipophilic compounds generally known as boronic acid adducts of technetium dioxime complexes (BATOs). After i.v. administration, the concentration of [ 99m Tc]DMG-2MP in various regions of the brain appears to be proportional to blood flow. In rats, 1.1% ID was in the brain at 5 min postinjection when the blood contained less than 3% ID. Over 24 hr excretion was 59% in the feces and 23% in the urine. The activity in monkey brain at 5 min was 2.8% ID and it cleared with a t1/2 of 86 min. Autoradiographs of monkey brain sections showed excellent regional detail with a gray/white ratio of 3.6 at 10 min. The distribution of [ 99m Tc]DMG-2MP in the monkey brain corresponds to the known cytoarchitectural pattern of cerebral glucose metabolism. The properties of [ 99m Tc]DMG-2MP make it a potentially useful agent for cerebral perfusion imaging in man

  5. Institutional Analysis of Knowledge Generation Resource Potential at the Enterprises of Regional Military-Industrial Complex

    Directory of Open Access Journals (Sweden)

    Evgeny Vasilyevich Popov

    2016-09-01

    Full Text Available The article is devoted to the processes of knowledge generation at the enterprises of military-industrial complex, which are the leaders of the regional innovative activity. The target of the research is to develop the methodology based on the use of resource application potential for increasing the efficiency of knowledge generation at the instrument-making enterprises of military-industrial complex. The system analysis of the knowledge generation processes is conducted at one of them. It allows to draw a conclusion that such enterprises have a lack of the institutes of knowledge generation processes. The authors are offered a technique of the development of the knowledge generation system at the military-industrial enterprises based on the accounting of assets and opportunities of the enterprise in the realization of intellectual activity. The developed technique is based on the determination of the horizontal resource potential of knowledge generation and allows to determine the potential of resource application at each stage of product life cycle. The comparison of the actual and theoretical values of horizontal resource potential allows to correct the distribution of a share of each of resources within a stage, and therefore, to optimize the realization of tasks at a specific stage. The offered tools were implemented in 2015 at one of the regional military-Industrial enterprises. The methodological tools of the research include the methods of expert assessment, mathematical statistics and the institutional analysis. On the basis of the offered technique and received empirical results, the institutional spiral of knowledge generation during the filling of state order at the military-industrial enterprise is developed. Its implementation will promote the decrease in the level of uncertainty during the whole life cycle of innovative activity product. The developed institutional spiral of knowledge generation at instrument-making military

  6. Complex and region-specific changes in astroglial markers in the aging brain.

    Science.gov (United States)

    Rodríguez, José J; Yeh, Chia-Yu; Terzieva, Slavica; Olabarria, Markel; Kulijewicz-Nawrot, Magdalena; Verkhratsky, Alexei

    2014-01-01

    Morphological aging of astrocytes was investigated in entorhinal cortex (EC), dentate gyrus (DG), and cornu ammonis 1 (CA1) regions of hippocampus of male SV129/C57BL6 mice of different age groups (3, 9, 18, and 24 months). Astroglial profiles were visualized by immunohistochemistry by using glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and s100β staining; these profiles were imaged using confocal or light microscopy for subsequent morphometric analysis. GFAP-positive profiles in the DG and the CA1 of the hippocampus showed progressive age-dependent hypertrophy, as indicated by an increase in surface, volume, and somata volume at 24 months of age compared with 3-month-old mice. In contrast with the hippocampal regions, aging induced a decrease in GFAP-positive astroglial profiles in the EC: the surface, volume, and cell body volume of astroglial cells at 24 months of age were decreased significantly compared with the 3-month group. The GS-positive astrocytes displayed smaller cellular surface areas at 24 months compared with 3-month-old animals in both areas of hippocampus, whereas GS-positive profiles remained unchanged in the EC of old mice. The morphometry of s100β-immunoreactive profiles revealed substantial increase in the EC, more moderate increase in the DG, and no changes in the CA1 area. Based on the morphological analysis of 3 astroglial markers, we conclude that astrocytes undergo a complex age-dependent remodeling in a brain region-specific manner. Copyright © 2014. Published by Elsevier Inc.

  7. Comparison of different wind data interpolation methods for a region with complex terrain in Central Asia

    Science.gov (United States)

    Reinhardt, Katja; Samimi, Cyrus

    2018-01-01

    While climatological data of high spatial resolution are largely available in most developed countries, the network of climatological stations in many other regions of the world still constitutes large gaps. Especially for those regions, interpolation methods are important tools to fill these gaps and to improve the data base indispensible for climatological research. Over the last years, new hybrid methods of machine learning and geostatistics have been developed which provide innovative prospects in spatial predictive modelling. This study will focus on evaluating the performance of 12 different interpolation methods for the wind components \\overrightarrow{u} and \\overrightarrow{v} in a mountainous region of Central Asia. Thereby, a special focus will be on applying new hybrid methods on spatial interpolation of wind data. This study is the first evaluating and comparing the performance of several of these hybrid methods. The overall aim of this study is to determine whether an optimal interpolation method exists, which can equally be applied for all pressure levels, or whether different interpolation methods have to be used for the different pressure levels. Deterministic (inverse distance weighting) and geostatistical interpolation methods (ordinary kriging) were explored, which take into account only the initial values of \\overrightarrow{u} and \\overrightarrow{v} . In addition, more complex methods (generalized additive model, support vector machine and neural networks as single methods and as hybrid methods as well as regression-kriging) that consider additional variables were applied. The analysis of the error indices revealed that regression-kriging provided the most accurate interpolation results for both wind components and all pressure heights. At 200 and 500 hPa, regression-kriging is followed by the different kinds of neural networks and support vector machines and for 850 hPa it is followed by the different types of support vector machine and

  8. Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset.

    Science.gov (United States)

    Ignatieva, Elena V; Levitsky, Victor G; Yudin, Nikolay S; Moshkin, Mikhail P; Kolchanov, Nikolay A

    2014-01-01

    The molecular mechanism of olfactory cognition is very complicated. Olfactory cognition is initiated by olfactory receptor proteins (odorant receptors), which are activated by olfactory stimuli (ligands). Olfactory receptors are the initial player in the signal transduction cascade producing a nerve impulse, which is transmitted to the brain. The sensitivity to a particular ligand depends on the expression level of multiple proteins involved in the process of olfactory cognition: olfactory receptor proteins, proteins that participate in signal transduction cascade, etc. The expression level of each gene is controlled by its regulatory regions, and especially, by the promoter [a region of DNA about 100-1000 base pairs long located upstream of the transcription start site (TSS)]. We analyzed single nucleotide polymorphisms using human whole-genome data from the 1000 Genomes Project and revealed an extremely high level of single nucleotide polymorphisms in promoter regions of olfactory receptor genes and HLA genes. We hypothesized that the high level of polymorphisms in olfactory receptor promoters was responsible for the diversity in regulatory mechanisms controlling the expression levels of olfactory receptor proteins. Such diversity of regulatory mechanisms may cause the great variability of olfactory cognition of numerous environmental olfactory stimuli perceived by human beings (air pollutants, human body odors, odors in culinary etc.). In turn, this variability may provide a wide range of emotional and behavioral reactions related to the vast variety of olfactory stimuli.

  9. Genetic basis of olfactory cognition: extremely high level of DNA sequence polymorphism in promoter regions of the human olfactory receptor genes revealed using the 1000 Genomes Project dataset

    Directory of Open Access Journals (Sweden)

    Elena V. Ignatieva

    2014-03-01

    Full Text Available The molecular mechanism of olfactory cognition is very complicated. Olfactory cognition is initiated by olfactory receptor proteins (odorant receptors, which are activated by olfactory stimuli (ligands. Olfactory receptors are the initial player in the signal transduction cascade producing a nerve impulse, which is transmitted to the brain. The sensitivity to a particular ligand depends on the expression level of multiple proteins involved in the process of olfactory cognition: olfactory receptor proteins, proteins that participate in signal transduction cascade, etc. The expression level of each gene is controlled by its regulatory regions, and especially, by the promoter (a region of DNA about 100–1000 base pairs long located upstream of the transcription start site. We analyzed single nucleotide polymorphisms using human whole-genome data from the 1000 Genomes Project and revealed an extremely high level of single nucleotide polymorphisms in promoter regions of olfactory receptor genes and HLA genes. We hypothesized that the high level of polymorphisms in olfactory receptor promoters was responsible for the diversity in regulatory mechanisms controlling the expression levels of olfactory receptor proteins. Such diversity of regulatory mechanisms may cause the great variability of olfactory cognition of numerous environmental olfactory stimuli perceived by human beings (air pollutants, human body odors, odors in culinary etc.. In turn, this variability may provide a wide range of emotional and behavioral reactions related to the vast variety of olfactory stimuli.

  10. Metamorphic and tectonic evolution of the Greater Himalayan Crystalline Complex in Nyalam region, south Tibet

    Science.gov (United States)

    Wang, Jia-Min; Zhang, Jin-Jiang; Rubatto, Daniela

    2016-04-01

    Recent studies evoke dispute whether the Himalayan metamorphic core - Greater Himalayan Crystalline Complex (GHC) - was exhumed as a lateral crustal flow or a critical taper wedge during the India-Asia collision. This contribution investigated the evolution of the GHC in the Nyalam region, south Tibet, with comprehensive studies on structural kinematics, metamorphic petrology and geochronology. The GHC in the Nyalam region can be divided into the lower and upper GHC. Phase equilibria modelling and conventional thermobarometric results show that peak temperature conditions are lower in the lower GHC (~660-700°C) and higher in the upper GHC (~740-780°C), whereas corresponding pressure conditions at peak-T decrease from ~9-13 kbar to ~4 kbar northward. Monazite, zircon and rutile U-Pb dating results reveal two distinct blocks within the GHC of the Nyalam region. The upper GHC underwent higher degree of partial melting (15-25%, via muscovite dehydration melting) that initiated at ~32 Ma, peaked at ~29 Ma to 25 Ma, possibly ended at ~20 Ma. The lower GHC underwent lower degree of melting (0-10%) that lasted from 19 to 16 Ma, which was produced mainly via H2O-saturated melting. At different times, both the upper and lower blocks underwent initial slow cooling (35 ± 8 and 10 ± 5°C/Myr, respectively) and subsequent rapid cooling (120 ± 40°C/Myr). The established timescale of metamorphism suggests that high-temperature metamorphism within the GHC lasted a long duration (~15 Myr), whereas duration of partial melting lasted for ~3 Myr in the lower GHC and lasted for 7-12 Myr in the upper GHC. The documented diachronous metamorphism and discontinuity of peak P-T conditions implies the presence of the Nyalam Thrust in the study area. This thrust is probably connected to the other thrusts in Nepal and Sikkim Himalaya, which extends over ~800 km and is named the "High Himalayan Thrust". Timing of activity along this thrust is at ~25-16 Ma, which is coeval with active

  11. A curative treatment option for Complex Regional Pain Syndrome (CRPS) Type I: dorsal root entry zone operation (report of two cases).

    Science.gov (United States)

    Kanpolat, Yucel; Al-Beyati, Eyyub; Ugur, Hasan Caglar; Akpinar, Gokhan; Kahilogullari, Gokmen; Bozkurt, Melih

    2014-01-01

    Complex Regional Pain Syndrome Type I (CRPS-I) is a debated health problem concerning its pathophysiology and treatment strategies. A 12-year-old boy and a 35-year-old woman were diagnosed with CRPS-I at different times. They had previously undergone various types of interventions with no success. After one year of follow-up and observation, DREZ lesioning operation was performed. Afterwards, both cases had transient lower extremity ataxia. The first case was followed for 60 months with no recurrence and total cure. The second case was pain-free until the 6th month, when she required psychological support; she was followed for 33 months with partial satisfactory outcome. Although not a first-line option, DREZ lesioning procedure can be chosen and may be a curative option in selected cases of CRPS-I who are unresponsive to conventional therapies.

  12. Disdrometer-based C-Band Radar Quantitative Precipitation Estimation (QPE) in a highly complex terrain region in tropical Colombia.

    Science.gov (United States)

    Sepúlveda, J.; Hoyos Ortiz, C. D.

    2017-12-01

    An adequate quantification of precipitation over land is critical for many societal applications including agriculture, hydroelectricity generation, water supply, and risk management associated with extreme events. The use of rain gauges, a traditional method for precipitation estimation, and an excellent one, to estimate the volume of liquid water during a particular precipitation event, does not allow to fully capture the highly spatial variability of the phenomena which is a requirement for almost all practical applications. On the other hand, the weather radar, an active remote sensing sensor, provides a proxy for rainfall with fine spatial resolution and adequate temporary sampling, however, it does not measure surface precipitation. In order to fully exploit the capabilities of the weather radar, it is necessary to develop quantitative precipitation estimation (QPE) techniques combining radar information with in-situ measurements. Different QPE methodologies are explored and adapted to local observations in a highly complex terrain region in tropical Colombia using a C-Band radar and a relatively dense network of rain gauges and disdrometers. One important result is that the expressions reported in the literature for extratropical locations are not representative of the conditions found in the tropical region studied. In addition to reproducing the state-of-the-art techniques, a new multi-stage methodology based on radar-derived variables and disdrometer data is proposed in order to achieve the best QPE possible. The main motivation for this new methodology is based on the fact that most traditional QPE methods do not directly take into account the different uncertainty sources involved in the process. The main advantage of the multi-stage model compared to traditional models is that it allows assessing and quantifying the uncertainty in the surface rain rate estimation. The sub-hourly rainfall estimations using the multi-stage methodology are realistic

  13. [Effect of shifting sand burial on evaporation reduction and salt restraint under saline water irrigation in extremely arid region].

    Science.gov (United States)

    Zhang, Jian-Guo; Zhao, Ying; Xu, Xin-Wen; Lei, Jia-Qiang; Li, Sheng-Yu; Wang, Yong-Dong

    2014-05-01

    The Taklimakan Desert Highway Shelterbelt is drip-irrigated with high saline groundwater (2.58-29.70 g x L(-1)), and shifting sand burial and water-salt stress are most common and serious problems in this region. So it is of great importance to study the effect of shifting sand burial on soil moisture evaporation, salt accumulation and their distribution for water saving, salinity restraint, and suitable utilization of local land and water resources. In this study, Micro-Lysimeters (MLS) were used to investigate dynamics of soil moisture and salt under different thicknesses of sand burial (1, 2, 3, 4, and 5 cm), and field control experiments of drip-irrigation were also carried out to investigate soil moisture and salt distribution under different thicknesses of shifting sand burial (5, 10, 15, 20, 25, 30, 35, and 40 cm). The soil daily and cumulative evaporation decreased with the increase of sand burial thickness in MLS, cumulative evaporation decreased by 2.5%-13.7% compared with control. And evaporative inhibiting efficiency increased with sand burial thickness, evaporative inhibiting efficiency of 1-5 cm sand burial was 16.7%-79.0%. Final soil moisture content beneath the interface of sand burial increased with sand burial thickness, and it increased by 2.5%-13.7% than control. The topsoil EC of shifting sand in MLS decreased by 1.19-6.00 mS x cm(-1) with the increasing sand burial thickness, whereas soil salt content beneath the interface in MLS increased and amplitude of the topsoil salt content was higher than that of the subsoil. Under drip-irrigation with saline groundwater, average soil moisture beneath the interface of shifting sand burial increased by 0.4% -2.0% compare with control, and the highest value of EC was 7.77 mS x cm(-1) when the sand burial thickness was 10 cm. The trend of salt accumulation content at shifting sand surface increased firstly, and then decreased with the increasing sand burial thickness. Soil salt contents beneath the

  14. Isolation of a cosmid sublibrary for a region of chromosome 12 frequently amplified in human cancers using a complex chromosome microdissection probe

    Energy Technology Data Exchange (ETDEWEB)

    Elkahloun, A.G.; Meltzer, P.S.; Guan, Xin-Yuan [National Institutes of Health, Bethesda, MD (United States)] [and others

    1996-02-01

    Chromosome-specific cosmid libraries are in extremely useful resource for positional cloning projects. Once a particular region of interest has been identified, it would be of value to have an approach for isolating chromosome band-specific cosmids that could be assembled into a sublibrary for rapid screening. We constructed a region-specific sublibrary of 700 cosmids by screening a chromosome 12-specific cosmid library with a complex probe generated by degenerate oligonucleotide-primed PCR of a microdissected homogeneously staining region containing sequences amplified from chromosome 12q13-q15. Based on fluorescence in situ hybridization, approximately 60% of the cosmids in the sublibrary were derived from the microdissected region. To demonstrate further the utility of the sublibrary, a 150-kb contig containing the SAS and CDK4 genes was constructed, as well as several additional contigs between CDK4 and MDM2. This study demonstrates the possibility of utilizing probes generated by microdissection for assembling band-specific libraries that are amendable to rapid screening with multiple markers.

  15. Effects of Revegetation on Soil Organic Carbon Storage and Erosion-Induced Carbon Loss under Extreme Rainstorms in the Hill and Gully Region of the Loess Plateau

    Directory of Open Access Journals (Sweden)

    Yujin Li

    2016-04-01

    Full Text Available Background: The Loess Plateau, an ecologically vulnerable region, has long been suffering from serious soil erosion. Revegetation has been implemented to control soil erosion and improve ecosystems in the Loess Plateau region through a series of ecological recovery programs. However, the increasing atmospheric CO2 as a result of human intervention is affecting the climate by global warming, resulting in the greater frequency and intensity of extreme weather events, such as storms that may weaken the effectiveness of revegetation and cause severe soil erosion. Most research to date has evaluated the effectiveness of revegetation on soil properties and soil erosion of different land use or vegetation types. Here, we study the effect of revegetation on soil organic carbon (SOC storage and erosion-induced carbon loss related to different plant communities, particularly under extreme rainstorm events. Materials and methods: The erosion-pin method was used to quantify soil erosion, and soil samples were taken at soil depths of 0–5 cm, 5–10 cm and 10–20 cm to determine the SOC content for 13 typical hillside revegetation communities in the year of 2013, which had the highest rainfall with broad range, long duration and high intensity since 1945, in the Yanhe watershed. Results and discussion: The SOC concentrations of all plant communities increased with soil depth when compared with slope cropland, and significant increases (p < 0.05 were observed for most shrub and forest communities, particularly for natural ones. Taking the natural secondary forest community as reference (i.e., soil loss and SOC loss were both 1.0, the relative soil loss and SOC loss of the other 12 plant communities in 2013 ranged from 1.5 to 9.4 and 0.30 to 1.73, respectively. Natural shrub and forest communities showed greater resistance to rainstorm erosion than grassland communities. The natural grassland communities with lower SOC content produced lower SOC loss even

  16. Effects of Revegetation on Soil Organic Carbon Storage and Erosion-Induced Carbon Loss under Extreme Rainstorms in the Hill and Gully Region of the Loess Plateau.

    Science.gov (United States)

    Li, Yujin; Jiao, Juying; Wang, Zhijie; Cao, Binting; Wei, Yanhong; Hu, Shu

    2016-04-29

    The Loess Plateau, an ecologically vulnerable region, has long been suffering from serious soil erosion. Revegetation has been implemented to control soil erosion and improve ecosystems in the Loess Plateau region through a series of ecological recovery programs. However, the increasing atmospheric CO₂ as a result of human intervention is affecting the climate by global warming, resulting in the greater frequency and intensity of extreme weather events, such as storms that may weaken the effectiveness of revegetation and cause severe soil erosion. Most research to date has evaluated the effectiveness of revegetation on soil properties and soil erosion of different land use or vegetation types. Here, we study the effect of revegetation on soil organic carbon (SOC) storage and erosion-induced carbon loss related to different plant communities, particularly under extreme rainstorm events. The erosion-pin method was used to quantify soil erosion, and soil samples were taken at soil depths of 0-5 cm, 5-10 cm and 10-20 cm to determine the SOC content for 13 typical hillside revegetation communities in the year of 2013, which had the highest rainfall with broad range, long duration and high intensity since 1945, in the Yanhe watershed. The SOC concentrations of all plant communities increased with soil depth when compared with slope cropland, and significant increases (p soil loss and SOC loss were both 1.0), the relative soil loss and SOC loss of the other 12 plant communities in 2013 ranged from 1.5 to 9.4 and 0.30 to 1.73, respectively. Natural shrub and forest communities showed greater resistance to rainstorm erosion than grassland communities. The natural grassland communities with lower SOC content produced lower SOC loss even with higher soil loss, natural secondary forest communities produced higher SOC loss, primarily because of their higher SOC content, and the artificial R. pseudoacacia community with greater soil loss produced higher SOC loss. These results

  17. Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

    Directory of Open Access Journals (Sweden)

    Chris Wallace

    2015-06-01

    Full Text Available Identification of candidate causal variants in regions associated with risk of common diseases is complicated by linkage disequilibrium (LD and multiple association signals. Nonetheless, accurate maps of these variants are needed, both to fully exploit detailed cell specific chromatin annotation data to highlight disease causal mechanisms and cells, and for design of the functional studies that will ultimately be required to confirm causal mechanisms. We adapted a Bayesian evolutionary stochastic search algorithm to the fine mapping problem, and demonstrated its improved performance over conventional stepwise and regularised regression through simulation studies. We then applied it to fine map the established multiple sclerosis (MS and type 1 diabetes (T1D associations in the IL-2RA (CD25 gene region. For T1D, both stepwise and stochastic search approaches identified four T1D association signals, with the major effect tagged by the single nucleotide polymorphism, rs12722496. In contrast, for MS, the stochastic search found two distinct competing models: a single candidate causal variant, tagged by rs2104286 and reported previously using stepwise analysis; and a more complex model with two association signals, one of which was tagged by the major T1D associated rs12722496 and the other by rs56382813. There is low to moderate LD between rs2104286 and both rs12722496 and rs56382813 (r2 ≃ 0:3 and our two SNP model could not be recovered through a forward stepwise search after conditioning on rs2104286. Both signals in the two variant model for MS affect CD25 expression on distinct subpopulations of CD4+ T cells, which are key cells in the autoimmune process. The results support a shared causal variant for T1D and MS. Our study illustrates the benefit of using a purposely designed model search strategy for fine mapping and the advantage of combining disease and protein expression data.

  18. Complex Regional Pain Syndrome Type I Affects Brain Structure in Prefrontal and Motor Cortex

    Science.gov (United States)

    Pleger, Burkhard; Draganski, Bogdan; Schwenkreis, Peter; Lenz, Melanie; Nicolas, Volkmar; Maier, Christoph; Tegenthoff, Martin

    2014-01-01

    The complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder that mostly occurs after injuries to the upper limb. A number of studies indicated altered brain function in CRPS, whereas possible influences on brain structure remain poorly investigated. We acquired structural magnetic resonance imaging data from CRPS type I patients and applied voxel-by-voxel statistics to compare white and gray matter brain segments of CRPS patients with matched controls. Patients and controls were statistically compared in two different ways: First, we applied a 2-sample ttest to compare whole brain white and gray matter structure between patients and controls. Second, we aimed to assess structural alterations specifically of the primary somatosensory (S1) and motor cortex (M1) contralateral to the CRPS affected side. To this end, MRI scans of patients with left-sided CRPS (and matched controls) were horizontally flipped before preprocessing and region-of-interest-based group comparison. The unpaired ttest of the “non-flipped” data revealed that CRPS patients presented increased gray matter density in the dorsomedial prefrontal cortex. The same test applied to the “flipped” data showed further increases in gray matter density, not in the S1, but in the M1 contralateral to the CRPS-affected limb which were inversely related to decreased white matter density of the internal capsule within the ipsilateral brain hemisphere. The gray-white matter interaction between motor cortex and internal capsule suggests compensatory mechanisms within the central motor system possibly due to motor dysfunction. Altered gray matter structure in dorsomedial prefrontal cortex may occur in response to emotional processes such as pain-related suffering or elevated analgesic top-down control. PMID:24416397

  19. Complex regional pain syndrome type I affects brain structure in prefrontal and motor cortex.

    Directory of Open Access Journals (Sweden)

    Burkhard Pleger

    Full Text Available The complex regional pain syndrome (CRPS is a rare but debilitating pain disorder that mostly occurs after injuries to the upper limb. A number of studies indicated altered brain function in CRPS, whereas possible influences on brain structure remain poorly investigated. We acquired structural magnetic resonance imaging data from CRPS type I patients and applied voxel-by-voxel statistics to compare white and gray matter brain segments of CRPS patients with matched controls. Patients and controls were statistically compared in two different ways: First, we applied a 2-sample ttest to compare whole brain white and gray matter structure between patients and controls. Second, we aimed to assess structural alterations specifically of the primary somatosensory (S1 and motor cortex (M1 contralateral to the CRPS affected side. To this end, MRI scans of patients with left-sided CRPS (and matched controls were horizontally flipped before preprocessing and region-of-interest-based group comparison. The unpaired ttest of the "non-flipped" data revealed that CRPS patients presented increased gray matter density in the dorsomedial prefrontal cortex. The same test applied to the "flipped" data showed further increases in gray matter density, not in the S1, but in the M1 contralateral to the CRPS-affected limb which were inversely related to decreased white matter density of the internal capsule within the ipsilateral brain hemisphere. The gray-white matter interaction between motor cortex and internal capsule suggests compensatory mechanisms within the central motor system possibly due to motor dysfunction. Altered gray matter structure in dorsomedial prefrontal cortex may occur in response to emotional processes such as pain-related suffering or elevated analgesic top-down control.

  20. Analysis of gene expression profile microarray data in complex regional pain syndrome.

    Science.gov (United States)

    Tan, Wulin; Song, Yiyan; Mo, Chengqiang; Jiang, Shuangjian; Wang, Zhongxing

    2017-09-01

    The aim of the present study was to predict key genes and proteins associated with complex regional pain syndrome (CRPS) using bioinformatics analysis. The gene expression profiling microarray data, GSE47603, which included peripheral blood samples from 4 patients with CRPS and 5 healthy controls, was obtained from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) in CRPS patients compared with healthy controls were identified using the GEO2R online tool. Functional enrichment analysis was then performed using The Database for Annotation Visualization and Integrated Discovery online tool. Protein‑protein interaction (PPI) network analysis was subsequently performed using Search Tool for the Retrieval of Interaction Genes database and analyzed with Cytoscape software. A total of 257 DEGs were identified, including 243 upregulated genes and 14 downregulated ones. Genes in the human leukocyte antigen (HLA) family were most significantly differentially expressed. Enrichment analysis demonstrated that signaling pathways, including immune response, cell motion, adhesion and angiogenesis were associated with CRPS. PPI network analysis revealed that key genes, including early region 1A binding protein p300 (EP300), CREB‑binding protein (CREBBP), signal transducer and activator of transcription (STAT)3, STAT5A and integrin α M were associated with CRPS. The results suggest that the immune response may therefore serve an important role in CRPS development. In addition, genes in the HLA family, such as HLA‑DQB1 and HLA‑DRB1, may present potential biomarkers for the diagnosis of CRPS. Furthermore, EP300, its paralog CREBBP, and the STAT family genes, STAT3 and STAT5 may be important in the development of CRPS.

  1. Solar resource assessment in complex orography: a comparison of available datasets for the Trentino region

    Science.gov (United States)

    Laiti, Lavinia; Giovannini, Lorenzo; Zardi, Dino

    2015-04-01

    The accurate assessment of the solar radiation available at the Earth's surface is essential for a wide range of energy-related applications, such as the design of solar power plants, water heating systems and energy-efficient buildings, as well as in the fields of climatology, hydrology, ecology and agriculture. The characterization of solar radiation is particularly challenging in complex-orography areas, where topographic shadowing and altitude effects, together with local weather phenomena, greatly increase the spatial and temporal variability of such variable. At present, approaches ranging from surface measurements interpolation to orographic down-scaling of satellite data, to numerical model simulations are adopted for mapping solar radiation. In this contribution a high-resolution (200 m) solar atlas for the Trentino region (Italy) is presented, which was recently developed on the basis of hourly observations of global radiation collected from the local radiometric stations during the period 2004-2012. Monthly and annual climatological irradiation maps were obtained by the combined use of a GIS-based clear-sky model (r.sun module of GRASS GIS) and geostatistical interpolation techniques (kriging). Moreover, satellite radiation data derived by the MeteoSwiss HelioMont algorithm (2 km resolution) were used for missing-data reconstruction and for the final mapping, thus integrating ground-based and remote-sensing information. The results are compared with existing solar resource datasets, such as the PVGIS dataset, produced by the Joint Research Center Institute for Energy and Transport, and the HelioMont dataset, in order to evaluate the accuracy of the different datasets available for the region of interest.

  2. Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors.

    Science.gov (United States)

    Lai, J C; Cooper, A J

    1986-11-01

    The substrate and cofactor requirements and some kinetic properties of the alpha-ketoglutarate dehydrogenase complex (KGDHC; EC 1.2.4.2, EC 2.3.1.61, and EC 1.6.4.3) in purified rat brain mitochondria were studied. Brain mitochondrial KGDHC showed absolute requirement for alpha-ketoglutarate, CoA and NAD, and only partial requirement for added thiamine pyrophosphate, but no requirement for Mg2+ under the assay conditions employed in this study. The pH optimum was between 7.2 and 7.4, but, at pH values below 7.0 or above 7.8, KGDHC activity decreased markedly. KGDHC activity in various brain regions followed the rank order: cerebral cortex greater than cerebellum greater than or equal to midbrain greater than striatum = hippocampus greater than hypothalamus greater than pons and medulla greater than olfactory bulb. Significant inhibition of brain mitochondrial KGDHC was noted at pathological concentrations of ammonia (0.2-2 mM). However, the purified bovine heart KGDHC and KGDHC activity in isolated rat heart mitochondria were much less sensitive to inhibition. At 5 mM both beta-methylene-D,L-aspartate and D,L-vinylglycine (inhibitors of cerebral glucose oxidation) inhibited the purified heart but not the brain mitochondrial enzyme complex. At approximately 10 microM, calcium slightly stimulated (by 10-15%) the brain mitochondrial KGDHC. At concentrations above 100 microM, calcium (IC50 = 1 mM) inhibited both brain mitochondrial and purified heart KGDHC. The present results suggest that some of the kinetic properties of the rat brain mitochondrial KGDHC differ from those of the purified bovine heart and rat heart mitochondrial enzyme complexes. They also suggest that the inhibition of KGDHC by ammonia and the consequent effect on the citric acid cycle fluxes may be of pathophysiological and/or pathogenetic importance in hyperammonemia and in diseases (e.g., hepatic encephalopathy, inborn errors of urea metabolism, Reye's syndrome) where hyperammonemia is a

  3. Projected sea level rise and changes in extreme storm surge and wave events during the 21st century in the region of Singapore

    Science.gov (United States)

    Cannaby, Heather; Palmer, Matthew D.; Howard, Tom; Bricheno, Lucy; Calvert, Daley; Krijnen, Justin; Wood, Richard; Tinker, Jonathan; Bunney, Chris; Harle, James; Saulter, Andrew; O'Neill, Clare; Bellingham, Clare; Lowe, Jason

    2016-05-01

    Singapore is an island state with considerable population, industries, commerce and transport located in coastal areas at elevations less than 2 m making it vulnerable to sea level rise. Mitigation against future inundation events requires a quantitative assessment of risk. To address this need, regional projections of changes in (i) long-term mean sea level and (ii) the frequency of extreme storm surge and wave events have been combined to explore potential changes to coastal flood risk over the 21st century. Local changes in time-mean sea level were evaluated using the process-based climate model data and methods presented in the United Nations Intergovernmental Panel on Climate Change Fifth Assessment Report (IPCC AR5). Regional surge and wave solutions extending from 1980 to 2100 were generated using ˜ 12 km resolution surge (Nucleus for European Modelling of the Ocean - NEMO) and wave (WaveWatchIII) models. Ocean simulations were forced by output from a selection of four downscaled ( ˜ 12 km resolution) atmospheric models, forced at the lateral boundaries by global climate model simulations generated for the IPCC AR5. Long-term trends in skew surge and significant wave height were then assessed using a generalised extreme value model, fit to the largest modelled events each year. An additional atmospheric solution downscaled from the ERA-Interim global reanalysis was used to force historical ocean model simulations extending from 1980 to 2010, enabling a quantitative assessment of model skill. Simulated historical sea-surface height and significant wave height time series were compared to tide gauge data and satellite altimetry data, respectively. Central estimates of the long-term mean sea level rise at Singapore by 2100 were projected to be 0.52 m (0.74 m) under the Representative Concentration Pathway (RCP)4.5 (8.5) scenarios. Trends in surge and significant wave height 2-year return levels were found to be statistically insignificant and/or physically

  4. Continuous Sub-daily Rainfall Simulation for Regional Flood Risk Assessment - Modelling of Spatio-temporal Correlation Structure of Extreme Precipitation in the Austrian Alps

    Science.gov (United States)

    Salinas, J. L.; Nester, T.; Komma, J.; Bloeschl, G.

    2017-12-01

    Generation of realistic synthetic spatial rainfall is of pivotal importance for assessing regional hydroclimatic hazard as the input for long term rainfall-runoff simulations. The correct reproduction of observed rainfall characteristics, such as regional intensity-duration-frequency curves, and spatial and temporal correlations is necessary to adequately model the magnitude and frequency of the flood peaks, by reproducing antecedent soil moisture conditions before extreme rainfall events, and joint probability of flood waves at confluences. In this work, a modification of the model presented by Bardossy and Platte (1992), where precipitation is first modeled on a station basis as a multivariate autoregressive model (mAr) in a Normal space. The spatial and temporal correlation structures are imposed in the Normal space, allowing for a different temporal autocorrelation parameter for each station, and simultaneously ensuring the positive-definiteness of the correlation matrix of the mAr errors. The Normal rainfall is then transformed to a Gamma-distributed space, with parameters varying monthly according to a sinusoidal function, in order to adapt to the observed rainfall seasonality. One of the main differences with the original model is the simulation time-step, reduced from 24h to 6h. Due to a larger availability of daily rainfall data, as opposite to sub-daily (e.g. hourly), the parameters of the Gamma distributions are calibrated to reproduce simultaneously a series of daily rainfall characteristics (mean daily rainfall, standard deviations of daily rainfall, and 24h intensity-duration-frequency [IDF] curves), as well as other aggregated rainfall measures (mean annual rainfall, and monthly rainfall). The calibration of the spatial and temporal correlation parameters is performed in a way that the catchment-averaged IDF curves aggregated at different temporal scales fit the measured ones. The rainfall model is used to generate 10.000 years of synthetic

  5. Regional molecular and cellular differences in the female rabbit Achilles tendon complex: potential implications for understanding responses to loading.

    Science.gov (United States)

    Huisman, Elise S; Andersson, Gustav; Scott, Alexander; Reno, Carol R; Hart, David A; Thornton, Gail M

    2014-05-01

    The aim of this study was: (i) to analyze the morphology and expression of extracellular matrix genes in six different regions of the Achilles tendon complex of intact normal rabbits; and (ii) to assess the effect of ovariohysterectomy (OVH) on the regional expression of these genes. Female New Zealand White rabbits were separated into two groups: (i) intact normal rabbits (n = 4); and (ii) OVH rabbits (n = 8). For each rabbit, the Achilles tendon complex was dissected into six regions: distal gastrocnemius (DG); distal flexor digitorum superficialis; proximal lateral gastrocnemius (PLG); proximal medial gastrocnemius; proximal flexor digitorum superficialis; and paratenon. For each of the regions, hematoxylin and eosin staining was performed for histological evaluation of intact normal rabbit tissues and mRNA levels for proteoglycans, collagens and genes associated with collagen regulation were assessed by real-time reverse transcription-quantitative polymerase chain reaction for both the intact normal and OVH rabbit tissues. The distal regions displayed a more fibrocartilaginous phenotype. For intact normal rabbits, aggrecan mRNA expression was higher in the distal regions of the Achilles tendon complex compared with the proximal regions. Collagen Type I and matrix metalloproteinase-2 expression levels were increased in the PLG compared to the DG in the intact normal rabbit tissues. The tendons from OVH rabbits had lower gene expressions for the proteoglycans aggrecan, biglycan, decorin and versican compared with the intact normal rabbits, although the regional differences of increased aggrecan expression in distal regions compared with proximal regions persisted. The tensile and compressive forces experienced in the examined regions may be related to the regional differences found in gene expression. The lower mRNA expression of the genes examined in the OVH group confirms a potential effect of systemic estrogen on tendon. © 2014 Anatomical Society.

  6. A study of the dose distribution in the region of the eye lens and extremities for staff working in interventional cardiology

    International Nuclear Information System (INIS)

    Domienik, J.; Brodecki, M.; Rusicka, D.

    2012-01-01

    The dose distributions at the region of eye lens and extremities of staff working in interventional cardiology were analyzed. The doses to physicians and nurses from three hospitals in Poland were measured with TL dosimeters (MCP-N) located on various places near eyebrows, on both fingers, wrists, knees and on the ankle. The procedures under investigation were coronary angiography (CA) and percutaneous coronary intervention (PCI), peacemaker and defibrillator implantations (PM/ICDs), cardiac resynchronization therapy with or without defibrillator implantations (CRT-D or CRT) and radiofrequency ablations (RFA). The study aimed at analyzing the distribution of radiation in selected anatomic regions, determining the typical locations of highest doses and estimating the dose ranges for selected types of procedures. The maximum registered doses per procedure to eye lens and ankle were 1.21 mSv and 1.46 mSv for CA PCI procedures, 0.02 mSv and 0.05 mSv for RFA and 0.13 mSv and 0.51 mSv for PM/ICDs, respectively. The maximum doses to fingers, wrists and knees were, accordingly, 2.11 mSv, 1.07 mSv and 0.77 mSv for CA PCI procedures, 0.38 mSv, 0.20 mSv and 0.04 mSv for RFA ones, 0.50 mSv, 0.25 mSv and 0.01 mSv for PM/ICDs procedures and 2.25 mSv, 1.12 mSv and 0.58 mSv for CRT and CRT-D ones. The factors which might influence the dose like utilized radiation, availability of additional protective equipment and position of the staff with respect to X-ray source were also analyzed. The annual doses for eye lens and extremities were estimated on the basis of individual annual workloads of the physicians participating in the study. The highest annual doses were revealed for physicians performing CA PCI procedures. Annual eye lens doses range up to 247 mSv indicating that the occupational limit for eye lens 150 mSv has been surpassed. In case of extremities the maximal estimated annual doses were 355 mSv, 136 mSv, 55 mSv and 328 mSv, for fingers, wrists, knees and for ankle

  7. INVESTMENT ACTIVITY OF AGRIBUSINESS IN THE AGROINDUSTRIAL COMPLEX REGION, AS ONE OF THE ELEMENTS OF THE FINANCIAL SECURITY OF THE AGRO-INDUSTRIAL COMPLEX OF THE STATE

    Directory of Open Access Journals (Sweden)

    Olga Nikolaevna Uglitskikh

    2015-09-01

    Full Text Available The developed economic-political situation around of Russia, specifies an indispensability of support of agricultural commodity producers as from their financial well-being, investment activity the financial security of agrarian and industrial complex of the state depends. Limitation of own financial resources at agrarians does not allow them to realize independently conceived projects. Studying of questions of formation and functioning of investment activity in agriculture of Stavropol Territory and an assessment of investment projects offered to reali-zation, have allowed to analyse investment activity of agrarian and industrial complex of region up to the introduction of Russia into WTO and in conditions of its membership. By results of the lead assessment the administrative areas of region showing the greatest investment activity, threats of a financial security of agrarian and industrial complex of region not putting by the activity have been revealed. It is drawn a conclusion on influence West-American sanctions on financial without-danger agra-rian and industrial complex of the state and the responsibility сельхозтоваропроизводителей about delivery of agricultural production in necessary volume and import substitution.

  8. Personality assessment of patients with complex regional pain syndrome type I.

    Science.gov (United States)

    Monti, D A; Herring, C L; Schwartzman, R J; Marchese, M

    1998-12-01

    There is controversy regarding the importance of psychological/psychiatric factors in the development of the Complex Regional Pain Syndrome (CRPS). Our objective was to determine whether CRPS type I patients were psychiatrically different from other chronic pain patients, with particular attention to personality pathology. A standardized clinical assessment of all major psychiatric categories, including personality disorders, was performed on 25 CRPS type I patients and a control group of 25 patients with chronic low back pain from disc-related radiculopathy. Both sections of the Structured Clinical Interview for the Diagnostic and Statistical Manual (3rd ed., rev.) and the visual analog scale. Both groups were similar in terms of pain intensity and duration. Statistical analysis showed both groups to have a significant amount of major psychiatric comorbidity, in particular major depressive disorder, and a high incidence of personality disorders. Therefore, intense chronic pain was associated with significant psychiatric comorbidity in both groups and in similar proportions. The high incidence of personality pathology in both groups may represent an exaggeration of maladaptive personality traits and coping styles as a result of a chronic, intense, state of pain.

  9. Proteomic identification of altered cerebral proteins in the complex regional pain syndrome animal model.

    Science.gov (United States)

    Nahm, Francis Sahngun; Park, Zee-Yong; Nahm, Sang-Soep; Kim, Yong Chul; Lee, Pyung Bok

    2014-01-01

    Complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder. Although the exact pathophysiology of CRPS is not fully understood, central and peripheral mechanisms might be involved in the development of this disorder. To reveal the central mechanism of CRPS, we conducted a proteomic analysis of rat cerebrum using the chronic postischemia pain (CPIP) model, a novel experimental model of CRPS. After generating the CPIP animal model, we performed a proteomic analysis of the rat cerebrum using a multidimensional protein identification technology, and screened the proteins differentially expressed between the CPIP and control groups. Results. A total of 155 proteins were differentially expressed between the CPIP and control groups: 125 increased and 30 decreased; expressions of proteins related to cell signaling, synaptic plasticity, regulation of cell proliferation, and cytoskeletal formation were increased in the CPIP group. However, proenkephalin A, cereblon, and neuroserpin were decreased in CPIP group. Altered expression of cerebral proteins in the CPIP model indicates cerebral involvement in the pathogenesis of CRPS. Further study is required to elucidate the roles of these proteins in the development and maintenance of CRPS.

  10. Proteomic Identification of Altered Cerebral Proteins in the Complex Regional Pain Syndrome Animal Model

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    Francis Sahngun Nahm

    2014-01-01

    Full Text Available Background. Complex regional pain syndrome (CRPS is a rare but debilitating pain disorder. Although the exact pathophysiology of CRPS is not fully understood, central and peripheral mechanisms might be involved in the development of this disorder. To reveal the central mechanism of CRPS, we conducted a proteomic analysis of rat cerebrum using the chronic postischemia pain (CPIP model, a novel experimental model of CRPS. Materials and Methods. After generating the CPIP animal model, we performed a proteomic analysis of the rat cerebrum using a multidimensional protein identification technology, and screened the proteins differentially expressed between the CPIP and control groups. Results. A total of 155 proteins were differentially expressed between the CPIP and control groups: 125 increased and 30 decreased; expressions of proteins related to cell signaling, synaptic plasticity, regulation of cell proliferation, and cytoskeletal formation were increased in the CPIP group. However, proenkephalin A, cereblon, and neuroserpin were decreased in CPIP group. Conclusion. Altered expression of cerebral proteins in the CPIP model indicates cerebral involvement in the pathogenesis of CRPS. Further study is required to elucidate the roles of these proteins in the development and maintenance of CRPS.

  11. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome

    Science.gov (United States)

    Becerra, Lino; Sava, Simona; Simons, Laura E.; Drosos, Athena M.; Sethna, Navil; Berde, Charles; Lebel, Alyssa A.; Borsook, David

    2014-01-01

    Pediatric complex regional pain syndrome (P-CRPS) offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS by measuring resting state networks before and following a brief (median = 3 weeks) but intensive physical and psychological treatment program, and compared them to matched healthy controls. Differences in intrinsic brain networks were observed in P-CRPS compared to controls before treatment (disease state) with the most prominent differences in the fronto-parietal, salience, default mode, central executive, and sensorimotor networks. Following treatment, behavioral measures demonstrated a reduction of symptoms and improvement of physical state (pain levels and motor functioning). Correlation of network connectivities with spontaneous pain measures pre- and post-treatment indicated concomitant reductions in connectivity in salience, central executive, default mode and sensorimotor networks (treatment effects). These results suggest a rapid alteration in global brain networks with treatment and provide a venue to assess brain changes in CRPS pre- and post-treatment, and to evaluate therapeutic effects. PMID:25379449

  12. Sex differences in complex regional pain syndrome type I (CRPS-I) in mice.

    Science.gov (United States)

    Tang, Chaoliang; Li, Juan; Tai, Wai Lydia; Yao, Weifeng; Zhao, Bo; Hong, Junmou; Shi, Si; Wang, Song; Xia, Zhongyuan

    2017-01-01

    Sex differences have been increasingly highlighted in complex regional pain syndrome (CRPS) in clinical practice. In CRPS type I (CRPS-I), although inflammation and oxidative stress have been implicated in its pathogenesis, whether pain behavior and the underlying mechanism are sex-specific is unclear. In the present study, we sought to explore whether sex differences have an impact on inflammation, oxidative stress, and pain sensitivity in CRPS-I. Chronic post-ischemia pain (CPIP) was established in both male and female mice as an animal model of CRPS-I. Edema and mechanical allodynia of bilateral hind paws were assessed after reperfusion. Blood samples were analyzed for serum levels of oxidative stress markers and inflammatory cytokines. Both male and female mice developed edema. Male mice developed CPIP at day 3 after reperfusion; female mice developed CPIP at day 2 after reperfusion. Female mice displayed significantly earlier and higher mechanical allodynia in the ischemic hind paw, which was associated with higher serum levels of IL-2, TNF-α, isoprostanes, 8 OhdG, and malondialdehyde at day 2 after reperfusion. Moreover, female mice showed significantly lower SOD and IL-4 compared to male mice at day 2 after reperfusion. Our results indicate that sex differences in inflammatory and oxidative stress states may play a central role in the sex-specific nociceptive hypersensitivity in CRPS-I, and offer a new insight into pharmacology treatments to improve pain management with CRPS.

  13. Local cytokine changes in complex regional pain syndrome type I (CRPS I) resolve after 6 months.

    Science.gov (United States)

    Lenz, Melanie; Uçeyler, Nurcan; Frettlöh, Jule; Höffken, Oliver; Krumova, Elena K; Lissek, Silke; Reinersmann, Annika; Sommer, Claudia; Stude, Philipp; Waaga-Gasser, Ana M; Tegenthoff, Martin; Maier, Christoph

    2013-10-01

    There is evidence that inflammatory processes are involved in at least the early phase of complex regional pain syndrome (CRPS). We compared a panel of pro- and antiinflammatory cytokines in skin blister fluids and serum from patients with CRPS and patients with upper-limb pain of other origin (non-CRPS) in the early stage (CRPS patients compared to non-CRPS patients. Neither group showed side differences. After 6 months under analgesic treatment, protein levels of all measured cytokines in CRPS patients, except for IL-6, significantly changed bilaterally to the level of non-CRPS patients. These changes were not related to treatment outcome. In serum, only IL-8, TNF-α, eotaxin, MCP-1, and MIP-1β were detectable without intergroup differences. Blister fluid of CRPS patients showed a bilateral proinflammatory cytokine profile. This profile seems to be relevant only at the early stage of CRPS. Almost all measured cytokine levels were comparable to those of non-CRPS patients after 6 months of analgesic treatment and were not related to treatment outcome. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  14. Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome

    Directory of Open Access Journals (Sweden)

    Lino Becerra

    2014-01-01

    Full Text Available Pediatric complex regional pain syndrome (P-CRPS offers a unique model of chronic neuropathic pain as it either resolves spontaneously or through therapeutic interventions in most patients. Here we evaluated brain changes in well-characterized children and adolescents with P-CRPS by measuring resting state networks before and following a brief (median = 3 weeks but intensive physical and psychological treatment program, and compared them to matched healthy controls. Differences in intrinsic brain networks were observed in P-CRPS compared to controls before treatment (disease state with the most prominent differences in the fronto-parietal, salience, default mode, central executive, and sensorimotor networks. Following treatment, behavioral measures demonstrated a reduction of symptoms and improvement of physical state (pain levels and motor functioning. Correlation of network connectivities with spontaneous pain measures pre- and post-treatment indicated concomitant reductions in connectivity in salience, central executive, default mode and sensorimotor networks (treatment effects. These results suggest a rapid alteration in global brain networks with treatment and provide a venue to assess brain changes in CRPS pre- and post-treatment, and to evaluate therapeutic effects.

  15. Impaired recognition of social emotion in patients with complex regional pain syndrome.

    Science.gov (United States)

    Shin, Na Young; Kang, Do-Hyung; Jang, Joon Hwan; Park, Soo Young; Hwang, Jae Yeon; Kim, Sung Nyun; Byun, Min Soo; Park, Hye Youn; Kim, Yong Chul

    2013-11-01

    Multiple brain areas involved in nociceptive, autonomic, and social-emotional processing are disproportionally changed in patients with complex regional pain syndrome (CRPS). Little empirical evidence is available involving social cognitive functioning in patients with chronic pain conditions. We investigated the ability of patients with CRPS to recognize the mental/emotional states of other people. Forty-three patients with CRPS and 30 healthy controls performed the Reading Mind in the Eyes Test, which consists of photos in which human eyes express various emotional and mental states. Neuropsychological tests, including the Wisconsin Card Sorting Test, the stop-signal test, and the reaction time test, were administered to evaluate other cognitive functions. Patients with CRPS were significantly less accurate at recognizing emotional states in other persons, but not on other cognitive tests, compared with control subjects. We found a significant association between the deficit in social-emotion recognition and the affective dimension of pain, whereas this deficit was not related to the sensory dimension of pain. Our findings suggest a disrupted ability to recognize others' mental/emotional states in patients with CRPS. This article demonstrated a deficit in inferring mental/emotional states of others in patients with CRPS that was related to pain affect. Our study suggests that additional interventions directed toward reducing distressful affective pain may be helpful to restore social cognitive processing in patients with CRPS. Copyright © 2013 American Pain Society. Published by Elsevier Inc. All rights reserved.

  16. Bee Venom Pharmacopuncture: An Effective Treatment for Complex Regional Pain Syndrome

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    Jong-Min Kim

    2014-12-01

    Full Text Available Objectives: Treating complex regional pain syndrome (CRPS is difficult because it still does not have a recommended therapy. A 29-year-old man was diagnosed with CRPS after surgery on his 4th and 5th left toes 7 years ago. Though he had undergone diverse pain treatment, the symptoms persisted, so he visited Dunsan Korean Medicine Hospital of Daejeon University. This case report presents results on the effect of bee venom pharmacopuncture in treating patient with CRPS. Methods: Bee venom pharmacopuncture (BVP, 0.15 to 0.4 mL dosage, was administered at GB43. The treatment was applied each week for a total 14 times. The symptoms were evaluated using a numeric rating scale (NRS and the dosage of pain medicine. Results: On the first visit, he was taking an anticonvulsant, a trycyclic antidepressant, and an analgesic. On the NRS the worst pain in the toes received a score of 8. He also complained of severe pain and hypersensitivity when the 4th and the 5th toes were touched just slightly. Other complaint included dyspepsia, rash, and depression. After treatment, on the NRS, the score for toe pain was 0, and he no longer needed to take pain medication. During the 4-months follow-up period, he has remained without pain; neither have additional symptoms appeared nor adverse events occurred. Conclusion: BVP may have potential benefits for treating patients with CRPS.

  17. Correlates and importance of neglect-like symptoms in complex regional pain syndrome.

    Science.gov (United States)

    Wittayer, Matthias; Dimova, Violeta; Birklein, Frank; Schlereth, Tanja

    2018-05-01

    Neglect-like symptoms (NLS) are frequently observed in complex regional pain syndrome (CRPS). The clinical meaning of NLS, however, is largely unknown. Therefore, this study sets out to assess the importance of NLS for patient outcome and to explore their clinical correlates. We assessed NLS in a group of 53 patients with CRPS and compared the results to 28 healthy volunteers. To define the origin of the NLS reports, we tested the subjective visual midline, performed a limb-laterality recognition test, and quantitative sensory testing. In addition, psychological and pain assessment scales were completed. Tests were analyzed with univariate and multivariate approaches. After 6 months, patients were reassessed and the influence of NLS on pain outcome was determined. Most patients reported NLS in the questionnaire, whereas subjective visual midline and limb-laterality recognition test in contrast to previous studies did not reveal perceptual disturbances. Neglect-like symptom scores were associated with pain and pain catastrophizing in acute CRPS and anxiety and thermal sensory loss in chronic CRPS. Furthermore, high NLS scores had a negative impact on pain outcome after 6 months. Our results indicate that NLS have a different meaning in acute and chronic CRPS and might be of prognostic value. Possibly, treatment should focus on reducing NLS.

  18. Evaluation of brain metabolite in patients with complex regional pain syndrome by MR spectroscopy

    International Nuclear Information System (INIS)

    Iwashita, Narihito; Fukui, Mikio; Nitta, Kazuhito; Anzawa, Noriyuki; Tomie, Hisashi; Nakanishi, Miho; Matsumoto, Tomikichi; Nosaka, Shuichi

    2010-01-01

    Recently brain imaging studies have shown that patients with chronic pain have an altered cortical processing of nociceptive inputs. We evaluated brain metabolites in patients with complex regional pain syndrome (CRPS) using MR spectroscopy. Absolute concentrations of N-acetylaspartate (NAA) and choline (Cho) were measured in anterior cingulate (ACC) and prefrontal cortices (PFC) of patients and volunteers as matched control. Psychological aspects of patients were also evaluated with Hospital Anxiety and Depression (HAD) scale, in addition to the intensity of pain by visual analog scale. In the ACC, CRPS patients had a significant decrease of NAA and a significant increase of Cho compared to the control. Furthermore, patients with anxiety scored by HAD scale had reduced NAA concentration in ACC compared to the patients without anxiety. In the PFC, there was a reduction of NAA in the patients compared with that in control. No correlation was observed between intensity of pain and these metabolites. These results suggest that metabolite changes in ACC and PFC could reflect the pathogenesis of CRPS. (author)

  19. Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome.

    Science.gov (United States)

    Hotta, Jaakko; Saari, Jukka; Koskinen, Miika; Hlushchuk, Yevhen; Forss, Nina; Hari, Riitta

    2017-03-01

    Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. In this study, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper limb CRPS patients (all female, ages 31-58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective. A pattern-classification analysis was applied to characterize brain areas where the activation pattern differed between CRPS patients and healthy subjects. Brain areas with statistically significant group differences (q frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus. Our findings indicate that CRPS impairs action observation by affecting brain areas related to pain processing and motor control. This article shows that in CRPS, the observation of others' motor actions induces abnormal neural activity in brain areas essential for sensorimotor functions and pain. These results build the cerebral basis for action-observation impairments in CRPS. Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.

  20. Psychological distress and stressful life events in pediatric complex regional pain syndrome

    Science.gov (United States)

    Wager, Julia; Brehmer, Hannah; Hirschfeld, Gerrit; Zernikow, Boris

    2015-01-01

    BACKGROUND: There is little knowledge regarding the association between psychological factors and complex regional pain syndrome (CRPS) in children. Specifically, it is not known which factors precipitate CRPS and which result from the ongoing painful disease. OBJECTIVES: To examine symptoms of depression and anxiety as well as the experience of stressful life events in children with CRPS compared with children with chronic primary headaches and functional abdominal pain. METHODS: A retrospective chart study examined children with CRPS (n=37) who received intensive inpatient pain treatment between 2004 and 2010. They were compared with two control groups (chronic primary headaches and functional abdominal pain; each n=37), who also received intensive inpatient pain treatment. Control groups were matched with the CRPS group with regard to admission date, age and sex. Groups were compared on symptoms of depression and anxiety as well as stressful life events. RESULTS: Children with CRPS reported lower anxiety and depression scores compared with children with abdominal pain. A higher number of stressful life events before and after the onset of the pain condition was observed for children with CRPS. CONCLUSIONS: Children with CRPS are not particularly prone to symptoms of anxiety or depression. Importantly, children with CRPS experienced more stressful life events than children with chronic headaches or abdominal pain. Prospective long-term studies are needed to further explore the potential role of stressful life events in the etiology of CRPS. PMID:26035287

  1. Cerebral glucose metabolism change in patients with complex regional pain syndrome. A PET study

    International Nuclear Information System (INIS)

    Shiraishi, Satoe; Kobayashi, Hidetoshi; Nihashi, Takashi

    2006-01-01

    The aim of this study was to examine abnormalities of the central nervous system in patients with chronic pain who were diagnosed with complex regional pain syndrome (CRPS). Brain activity was assessed using 18 F-fluorodeoxyglucose positron emission tomography. The data collected from 18 patients were compared with data obtained from 13 normal age-matched controls. Our results showed that glucose metabolism was bilaterally increased in the secondary somatosensory cortex, mid-anterior cingulated cortex (ACC) or posterior cingulated cortex (PCC) (or both), parietal cortex, posterior parietal cortex (PPC), and cerebellum as well as in the right posterior insula and right thalamus in our patients. In contrast, glucose metabolism was reduced contralaterally in the dorsal prefrontal cortex and primary motor cortex. Glucose metabolism was bilaterally elevated in the mid-ACC/PCC and the PPC, which correlated with pain duration. These data suggested that glucose metabolism in the brains of patients with CRPS changes dramatically at each location. In particular, glucose metabolism was increased in the areas concerned with somatosensory perception, possibly due to continuous painful stimulation. (author)

  2. Methodical Approaches To Analysis And Forecasting Of Development Fuel And Energy Complex And Gas Industry In The Region

    Directory of Open Access Journals (Sweden)

    Vladimir Andreyevich Tsybatov

    2014-12-01

    Full Text Available Fuel and energy complex (FEC is one of the main elements of the economy of any territory over which intertwine the interests of all economic entities. To ensure economic growth of the region should ensure that internal balance of energy resources, which should be developed with account of regional specifics of economic growth and energy security. The study examined the status of this equilibrium, indicating fuel and energy balance of the region (TEB. The aim of the research is the development of the fuel and energy balance, which will allow to determine exactly how many and what resources are not enough to ensure the regional development strategy and what resources need to be brought in. In the energy balances as the focus of displays all issues of regional development, so thermopile is necessary as a mechanism of analysis of current issues, economic development, and in the forward-looking version — as a tool future vision for the fuel and energy complex, energy threats and ways of overcoming them. The variety of relationships in the energy sector with other sectors and aspects of society lead to the fact that the development of the fuel and energy balance of the region have to go beyond the actual energy sector, involving the analysis of other sectors of economy, as well as systems such as banking, budgetary, legislative, tax. Due to the complexity of the discussed problems, the obvious is the need to develop appropriate forecast-analytical system, allowing regional authorities to implement evidence-based predictions of the consequences of management decisions. Multivariant scenario study on development of fuel and energy complex and separately industry, to use the methods of project-based management, harmonized application of state regulation of strategic and market mechanisms on the operational directions of development of fuel and energy complex and separately industry in the economy of the region.

  3. Mitochondrial Complex 1 Activity Measured by Spectrophotometry Is Reduced across All Brain Regions in Ageing and More Specifically in Neurodegeneration.

    Science.gov (United States)

    Pollard, Amelia Kate; Craig, Emma Louise; Chakrabarti, Lisa

    2016-01-01

    Mitochondrial function, in particular complex 1 of the electron transport chain (ETC), has been shown to decrease during normal ageing and in neurodegenerative disease. However, there is some debate concerning which area of the brain has the greatest complex 1 activity. It is important to identify the pattern of activity in order to be able to gauge the effect of age or disease related changes. We determined complex 1 activity spectrophotometrically in the cortex, brainstem and cerebellum of middle aged mice (70-71 weeks), a cerebellar ataxic neurodegeneration model (pcd5J) and young wild type controls. We share our updated protocol on the measurements of complex1 activity and find that mitochondrial fractions isolated from frozen tissues can be measured for robust activity. We show that complex 1 activity is clearly highest in the cortex when compared with brainstem and cerebellum (p<0.003). Cerebellum and brainstem mitochondria exhibit similar levels of complex 1 activity in wild type brains. In the aged brain we see similar levels of complex 1 activity in all three-brain regions. The specific activity of complex 1 measured in the aged cortex is significantly decreased when compared with controls (p<0.0001). Both the cerebellum and brainstem mitochondria also show significantly reduced activity with ageing (p<0.05). The mouse model of ataxia predictably has a lower complex 1 activity in the cerebellum, and although reductions are measured in the cortex and brain stem, the remaining activity is higher than in the aged brains. We present clear evidence that complex 1 activity decreases across the brain with age and much more specifically in the cerebellum of the pcd5j mouse. Mitochondrial impairment can be a region specific phenomenon in disease, but in ageing appears to affect the entire brain, abolishing the pattern of higher activity in cortical regions.

  4. Systemic inflammatory mediators in post-traumatic complex regional pain syndrome (CRPS I) - longitudinal investigations and differences to control groups.

    Science.gov (United States)

    Schinkel, Christian; Scherens, A; Köller, M; Roellecke, G; Muhr, G; Maier, C

    2009-03-17

    The Complex Regional Pain Syndrome I (CRPS I) is a disease that might affect an extremity after trauma or operation. The pathogenesis remains yet unclear. It has clinical signs of severe local inflammation as a result of an exaggerated inflammatory response but neurogenic dysregulation also contributes to it. Some studies investigated the role inflammatory mediators and cytokines; however, few longitudinal studies exist and control groups except healthy controls were not investigated yet. To get further insights into the role of systemic inflammatory mediators in CRPS I, we investigated a variety of pro-, anti-, or neuro-inflammatory mediators such as C-Reactive Protein (CRP), White Blood Cell Count (WBC), Interleukins 4, 6, 8, 10, 11, 12 (p70), Interferon gamma, Tumor-Necrosis-Factor alpha (TNF-a) and its soluble Receptors I/II, soluble Selectins (E,L,P), Substance-P (SP), and Calcitonin Gene-Related Peptide (CGRP) at different time points in venous blood from patients with acute (AC) and chronic (CC) CRPS I, patients with forearm fractures (FR), with neuralgia (NE), and from healthy volunteers (C). No significant changes for serum parameters investigated in CRPS compared to control groups were found except for CC/C (CGRP p = 0.007), FR/C (CGRP p = 0.048) and AC/CC (IL-12 p = 0.02; TNFRI/II p = 0.01; SP p = 0.049). High interindividual variations were observed. No intra- or interindividual correlation of parameters with clinical course (e.g. chronification) or outcome was detectable. Although clinically appearing as inflammation in acute stages, local rather than systemic inflammatory responses seem to be relevant in CRPS. Variable results from different studies might be explained by unpredictable intermittent release of mediators from local inflammatory processes into the blood combined with high interindividual variabilities. A clinically relevant difference to various control groups was not notable in this pilot study. Determination of systemic inflammatory

  5. Systemic inflammatory mediators in post-traumatic Complex Regional Pain Syndrome (CRPS I - longitudinal investigations and differences to control groups

    Directory of Open Access Journals (Sweden)

    Schinkel Ch

    2009-03-01

    Full Text Available Abstract Objectives The Complex Regional Pain Syndrome I (CRPS I is a disease that might affect an extremity after trauma or operation. The pathogenesis remains yet unclear. It has clinical signs of severe local inflammation as a result of an exaggerated inflammatory response but neurogenic dysregulation also contributes to it. Some studies investigated the role inflammatory mediators and cytokines; however, few longitudinal studies exist and control groups except healthy controls were not investigated yet. Methods To get further insights into the role of systemic inflammatory mediators in CRPS I, we investigated a variety of pro-, anti-, or neuro-inflammatory mediators such as C-Reactive Protein (CRP, White Blood Cell Count (WBC, Interleukins 4, 6, 8, 10, 11, 12 (p70, Interferon gamma, Tumor-Necrosis-Factor alpha (TNF-α and its soluble Receptors I/II, soluble Selectins (E, L, P, Substance-P (SP, and Calcitonin Gene-Related Peptide (CGRP at different time points in venous blood from patients with acute (AC and chronic (CC CRPS I, patients with forearm fractures (FR, with neuralgia (NE, and from healthy volunteers (C. Results No significant changes for serum parameters investigated in CRPS compared to control groups were found except for CC/C (CGRP p = 0.007, FR/C (CGRP p = 0.048 and AC/CC (IL-12 p = 0.02; TNFRI/II p = 0.01; SP p = 0.049. High interindividual variations were observed. No intra-or interindividual correlation of parameters with clinical course (e.g. chronification or outcome was detectable. Conclusion Although clinically appearing as inflammation in acute stages, local rather than systemic inflammatory responses seem to be relevant in CRPS. Variable results from different studies might be explained by unpredictable intermittent release of mediators from local inflammatory processes into the blood combined with high interindividual variabilities. A clinically relevant difference to various control groups was not notable in this

  6. Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

    International Nuclear Information System (INIS)

    Husen, S.; Clinton, J. F.; Kissling, E.

    2011-01-01

    One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

  7. Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Husen, S.; Clinton, J. F. [Swiss Seismological Service, ETH Zuerich, Zuerich (Switzerland); Kissling, E. [Institute of Geophysics, ETH Zuerich, Zuerich (Switzerland)

    2011-10-15

    One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

  8. Are more complex physiological models of forest ecosystems better choices for plot and regional predictions?

    Science.gov (United States)

    Wenchi Jin; Hong S. He; Frank R. Thompson

    2016-01-01

    Process-based forest ecosystem models vary from simple physiological, complex physiological, to hybrid empirical-physiological models. Previous studies indicate that complex models provide the best prediction at plot scale with a temporal extent of less than 10 years, however, it is largely untested as to whether complex models outperform the other two types of models...

  9. An approach for a complex assessment of the geo-ecological risk from natural disasters in a geographic region

    International Nuclear Information System (INIS)

    Zlateva, Plamena; Stoyanov, Krasimir

    2009-01-01

    The paper proposes an approach for a complex assessment of the geo-ecological risk of a certain geographic region on the basis of quantitative and qualitative datum about the potential natural disasters. A fuzzy logic model is designed. The type of the threats, consequences and interdependencies between infrastructure objects are taken into account. The geographic region is considered as a complex system of interconnected and mutually influencing elements. The expected damages are directly and/or indirectly connected with life quality deterioration. Keywords: Risk, Geo-ecological risk, Damages, Threats, Vulnerabilities, Natural disasters

  10. Application of digital tomosynthesis in diagnosing the fractures or dislocations in irregular bones and regions with complex structures.

    Science.gov (United States)

    Tuerdi, Batuer; Wang, Hui; Zhang, Ying; Zhou, Hao; Zhang, Hao

    2015-01-01

    The application potential of digital tomosynthesis in diagnosing fractures or dislocations in irregular bones and regions with complex structures was evaluated. Digital radiography and tomosynthesis were performed in 121 patients, and the image quality, accuracy, sensitivity, and specificity were compared. The number of participants with a definite diagnosis of fracture and/or dislocation was 98. The ratio of excellent images, accuracy, sensitivity, and specificity of digital tomosynthesis were higher than that of direct radiography. Digital tomosynthesis could be applied in the diagnosis of fractures or dislocations in irregular bones and regions with complex structures. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism.

    Directory of Open Access Journals (Sweden)

    Sebastiano Collino

    Full Text Available The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort compromising mostly female centenarians, elderly, and young individuals. With increasing age, targeted MS profiling of blood serum displayed a marked decrease in tryptophan concentration, while an unique alteration of specific glycerophospholipids and sphingolipids are seen in the longevity phenotype. We hypothesized that the overall lipidome changes specific to longevity putatively reflect centenarians' unique capacity to adapt/respond to the accumulating oxidative and chronic inflammatory conditions characteristic of their extreme aging phenotype. Our data in centenarians support promotion of cellular detoxification mechanisms through specific modulation of the arachidonic acid metabolic cascade as we underpinned increased concentration of 8,9-EpETrE, suggesting enhanced cytochrome P450 (CYP enzyme activity. Such effective mechanism might result in the activation of an anti-oxidative response, as displayed by decreased circulating levels of 9-HODE and 9-oxoODE, markers of lipid peroxidation and oxidative products of linoleic acid. Lastly, we also revealed that the longevity process deeply affects the structure and composition of the human gut microbiota as shown by the increased extrection of phenylacetylglutamine (PAG and p-cresol sulfate (PCS in urine of centenarians. Together, our novel approach in this representative Italian longevity cohort support the hypothesis that a complex remodeling of lipid, amino acid metabolism, and of gut microbiota functionality are key regulatory processes marking exceptional longevity in humans.

  12. [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome

    Science.gov (United States)

    Jeon, So Yeon; Seo, Seongho; Lee, Jae Sung; Choi, Soo-Hee; Lee, Do-Hyeong; Jung, Ye-Ha; Song, Man-Kyu; Lee, Kyung-Jun; Kim, Yong Chul; Kwon, Hyun Woo; Im, Hyung-Jun; Lee, Dong Soo; Cheon, Gi Jeong; Kang, Do-Hyung

    2017-01-01

    Abstract Complex regional pain syndrome (CRPS) is characterized by severe and chronic pain, but the pathophysiology of this disease are not clearly understood. The primary aim of our case–control study was to explore neuroinflammation in patients with CRPS using positron emission tomography (PET), with an 18-kDa translocator protein specific radioligand [11C]-(R)-PK11195. [11C]-(R)-PK11195 PET scans were acquired for 11 patients with CRPS (30–55 years) and 12 control subjects (30–52 years). Parametric image of distribution volume ratio (DVR) for each participant was generated by applying a relative equilibrium-based graphical analysis. The DVR of [11C]-(R)-PK11195 in the caudate nucleus (t(21) = −3.209, P = 0.004), putamen (t(21) = −2.492, P = 0.022), nucleus accumbens (t(21) = −2.218, P = 0.040), and thalamus (t(21) = −2.395, P = 0.026) were significantly higher in CRPS patients than in healthy controls. Those of globus pallidus (t(21) = −2.045, P = 0.054) tended to be higher in CRPS patients than in healthy controls. In patients with CRPS, there was a positive correlation between the DVR of [11C]-(R)-PK11195 in the caudate nucleus and the pain score, the visual analog scale (r = 0.661, P = 0.026, R2 = 0.408) and affective subscales of McGill Pain Questionnaire (r = 0.604, P = 0.049, R2 = 0.364). We demonstrated that neuroinflammation of CRPS patients in basal ganglia. Our results suggest that microglial pathology can be an important pathophysiology of CRPS. Association between the level of caudate nucleus and pain severity indicated that neuroinflammation in this region might play a key role. These results may be essential for developing effective medical treatments. PMID:28072713

  13. A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients.

    Science.gov (United States)

    Russo, Marc A; Santarelli, Danielle M

    2016-01-01

    Evidence suggests that complex regional pain syndrome (CRPS) is a manifestation of microvascular dysfunction. Topical combinations of α2-adrenergic receptor agonists or nitric oxide donors with phosphodiesterase or phosphatidic acid inhibitors formulated to treat microvascular dysfunction have been shown to reduce allodynia in a rat model of CRPS-I. Driven by these findings, we assessed the outcomes of CRPS patients treated with a compound analgesic cream (CAC) consisting of ketamine 10%, pentoxifylline 6%, clonidine 0.2%, and dimethyl sulfoxide 6% to 10%. An audit was conducted on 13 CRPS patients who trialed the CAC. A detailed report was compiled for each patient which comprised baseline characteristics, including CRPS description, previous treatments, and pain scores (numerical pain rating scale; 0 to 10). Recorded outcomes consisted of pain scores, descriptive outcomes, and concurrent medications/treatments, for which basic analysis was performed to determine the effectiveness of the CAC. Case reports are presented for 3 patients with varying outcomes. Nine patients (69%) reported pain/symptom reduction (4.4 ± 2.1 vs. 6.3 ± 1.9) with use of the CAC. Six patients reported sustained benefits after 2 months of CAC use, and 2 patients reported complete resolution of pain/symptoms: one had early CRPS-I and the other received a partial CRPS diagnosis. An otherwise medication refractory and intolerant patient found partial benefit with the CAC. These results demonstrate promise for this topical combination as a useful treatment in multimodal therapy for patients with CRPS, with the potential to resolve pain/symptoms in early CRPS patients. © 2015 World Institute of Pain.

  14. Pain increases during sympathetic arousal in patients with complex regional pain syndrome.

    Science.gov (United States)

    Drummond, P D; Finch, P M; Skipworth, S; Blockey, P

    2001-10-09

    To investigate the effect of sympathetic arousal on pain and vasomotor responses in healthy control subjects and patients with complex regional pain syndrome (CRPS), and to determine whether pain increases in patients with particular symptoms. In experiments 1 and 2, capsaicin was applied to the forearm of 24 healthy subjects to induce thermal hyperalgesia. Vascular responses were monitored and subjects rated thermal hyperalgesia before and after being startled (experiment 1), and before, during, and after mental arithmetic, breath holding, forehead cooling, the Valsalva maneuver, and a cold pressor test in experiment 2. In a third experiment, sensitivity to heat, cold, and mechanical stimulation was investigated in 61 patients with CRPS. Pain ratings and vascular and electrodermal responses were recorded after patients were startled and during forehead cooling. In experiment 1, thermal hyperalgesia decreased in healthy control subjects after they were startled, and digital blood vessels constricted symmetrically. In experiment 2, thermal hyperalgesia decreased during and after other forms of sympathetic arousal. However, in experiment 3, ratings of clinical pain increased during forehead cooling or after being startled in over 70% of patients with CRPS. Pain increased most consistently during forehead cooling in patients with cold allodynia or punctate allodynia. Digital blood vessels constricted more intensely on the symptomatic than the nonsymptomatic side in patients with CRPS during sympathetic arousal. Normal inhibitory influences on pain during sympathetic arousal are compromised in the majority of patients with CRPS. The augmented vasoconstrictor response in the symptomatic limb during sympathetic arousal is consistent with adrenergic supersensitivity. An adrenergic sensitivity in nociceptive afferents might contribute to pain and hyperalgesia during sympathetic arousal in certain patients with CRPS.

  15. Selective Fiber Degeneration in the Peripheral Nerve of a Patient With Severe Complex Regional Pain Syndrome

    Directory of Open Access Journals (Sweden)

    Adrien Yvon

    2018-04-01

    Full Text Available Aims: Complex regional pain syndrome (CRPS is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive. An exceptional case of severe CRPS leading to forearm amputation provided the opportunity to examine nerve histopathological features of the peripheral nerves.Methods: A 35-year-old female developed CRPS secondary to low voltage electrical injury. The CRPS was refractory to medical therapy and led to functional loss of the forelimb, repeated cutaneous wound infections leading to hospitalization. Specifically, the patient had exhausted a targeted conservative pain management programme prior to forearm amputation. Radial, median, and ulnar nerve specimens were obtained from the amputated limb and analyzed by light and transmission electron microscopy (TEM.Results: All samples showed features of selective myelinated nerve fiber degeneration (47–58% of fibers on electron microscopy. Degenerating myelinated fibers were significantly larger than healthy fibers (p < 0.05, and corresponded to the larger Aα fibers (motor/proprioception whilst smaller Aδ (pain/temperature fibers were spared. Groups of small unmyelinated C fibers (Remak bundles also showed evidence of degeneration in all samples.Conclusions: We are the first to show large fiber degeneration in CRPS using TEM. Degeneration of Aα fibers may lead to an imbalance in nerve signaling, inappropriately triggering the smaller healthy Aδ fibers, which transmit pain and temperature. These findings suggest peripheral nerve degeneration may play a key role in CRPS. Improved knowledge of pathogenesis will help develop more targeted treatments.

  16. Children and adolescents with complex regional pain syndrome: More psychologically distressed than other children in pain?

    Science.gov (United States)

    Logan, Deirdre E; Williams, Sara E; Carullo, Veronica P; Claar, Robyn Lewis; Bruehl, Stephen; Berde, Charles B

    2013-01-01

    BACKGROUND Historically, in both adult and pediatric populations, a lack of knowledge regarding complex regional pain syndrome (CRPS) and absence of clear diagnostic criteria have contributed to the view that this is a primarily psychiatric condition. OBJECTIVE: To test the hypothesis that children with CRPS are more functionally disabled, have more pain and are more psychologically distressed than children with other pain conditions. METHODS: A total of 101 children evaluated in a tertiary care pediatric pain clinic who met the International Association for the Study of Pain consensus diagnostic criteria for CRPS participated in the present retrospective study. Comparison groups included 103 children with abdominal pain, 291 with headache and 119 with back pain. Children and parents completed self-report questionnaires assessing disability, somatization, pain coping, depression, anxiety and school attendance. RESULTS: Children with CRPS reported higher pain intensity and more recent onset of pain at the initial tertiary pain clinic evaluation compared with children with other chronic pain conditions. They reported greater functional disability and more somatic symptoms than children with headaches or back pain. Scores on measures of depression and anxiety were within normal limits and similar to those of children in other pain diagnostic groups. CONCLUSIONS: As a group, clinic-referred children with CRPS may be more functionally impaired and experience more somatic symptoms compared with children with other pain conditions. However, overall psychological functioning as assessed by self-report appears to be similar to that of children with other chronic pain diagnoses. Comprehensive assessment using a biopsychosocial framework is essential to understanding and appropriately treating children with symptoms of CRPS. PMID:23662291

  17. Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS I).

    Science.gov (United States)

    Reinersmann, Annika; Landwehrt, Julia; Krumova, Elena K; Ocklenburg, Sebastian; Güntürkün, Onur; Maier, Christoph

    2012-11-01

    Recently, a shift of the visual subjective body midline (vSM), a correlate of the egocentric reference frame, towards the affected side was reported in patients with complex regional pain syndrome (CRPS). However, the specificity of this finding is as yet unclear. This study compares 24 CRPS patients to 21 patients with upper limb pain of other origin (pain control) and to 24 healthy subjects using a comprehensive test battery, including assessment of the vSM in light and dark, line bisection, hand laterality recognition, neglect-like severity symptoms, and motor impairment (disability of the arm, shoulder, and hand). 1-way analysis of variance, t-tests, significance level: 0.05. In the dark, CRPS patients displayed a significantly larger leftward spatial bias when estimating their vSM, compared to pain controls and healthy subjects, and also reported lower motor function than pain controls. For right-affected CRPS patients only, the deviation of the vSM correlated significantly with the severity of distorted body perception. Results confirm previous findings of impaired visuospatial perception in CRPS patients, which might be the result of the involvement of supraspinal mechanisms in this pain syndrome. These mechanisms might accentuate the leftward bias that results from a right-hemispheric dominance in visuospatial processing and is known as pseudoneglect. Pseudoneglect reveals itself in the tendency to perceive the midpoint of horizontal lines or the subjective body midline left of the centre. It was observable in all 3 groups, but most pronounced in CRPS patients, which might be due to the cortical reorganisation processes associated with this syndrome. Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  18. Medical history and the onset of complex regional pain syndrome (CRPS).

    Science.gov (United States)

    de Mos, M; Huygen, F J P M; Dieleman, J P; Koopman, J S H A; Stricker, B H Ch; Sturkenboom, M C J M

    2008-10-15

    Knowledge concerning the medical history prior to the onset of complex regional pain syndrome (CRPS) might provide insight into its risk factors and potential underlying disease mechanisms. To evaluate prior to CRPS medical conditions, a case-control study was conducted in the Integrated Primary Care Information (IPCI) project, a general practice (GP) database in the Netherlands. CRPS patients were identified from the records and validated through examination by the investigator (IASP criteria) or through specialist confirmation. Cases were matched to controls on age, gender and injury type. All diagnoses prior to the index date were assessed by manual review of the medical records. Some pre-specified medical conditions were studied for their association with CRPS, whereas all other diagnoses, grouped by pathogenesis, were tested in a hypothesis-generating approach. Of the identified 259 CRPS patients, 186 cases (697 controls) were included, based on validation by the investigator during a visit (102 of 134 visited patients) or on specialist confirmation (84 of 125 unvisited patients). A medical history of migraine (OR: 2.43, 95% CI: 1.18-5.02) and osteoporosis (OR: 2.44, 95% CI: 1.17-5.14) was associated with CRPS. In a recent history (1-year before CRPS), cases had more menstrual cycle-related problems (OR: 2.60, 95% CI: 1.16-5.83) and neuropathies (OR: 5.7; 95% CI: 1.8-18.7). In a sensitivity analysis, including only visited cases, asthma (OR: 3.0; 95% CI: 1.3-6.9) and CRPS were related. Psychological factors were not associated with CRPS onset. Because of the hypothesis-generating character of this study, the findings should be confirmed by other studies.

  19. A prospective, multisite, international validation of the Complex Regional Pain Syndrome Severity Score.

    Science.gov (United States)

    Harden, R Norman; Maihofner, Christian; Abousaad, Elias; Vatine, Jean-Jacques; Kirsling, Amy; Perez, Roberto S G M; Kuroda, Maxine; Brunner, Florian; Stanton-Hicks, Michael; Marinus, Johan; van Hilten, Jacobus J; Mackey, Sean; Birklein, Frank; Schlereth, Tanja; Mailis-Gagnon, Angela; Graciosa, Joe; Connoly, Sara B; Dayanim, David; Massey, Michael; Frank, Hadas; Livshitz, Anatoly; Bruehl, Stephen

    2017-08-01

    Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a continuous index of CRPS severity. Using a prospective design, medical evaluations were conducted in 156 patients with CRPS to compare changes over time in CSS scores between patients initiating a new treatment program and patients on stable treatment regimens. New vs stable categorizations were supported by greater changes in pain and function in the former. Results indicated that CSS values in the stable CRPS treatment group exhibited much less change over time relative to the new treatment group, with intraclass correlations nearly twice as large in the former. A calculated smallest real difference value revealed that a change in the CSS of ≥4.9 scale points would indicate real differences in CRPS symptomatology (with 95% confidence). Across groups, larger changes in CRPS features on the CSS over time were associated in the expected direction with greater changes in pain intensity, fatigue, social functioning, ability to engage in physical roles, and general well-being. The overall pattern of findings further supports the validity of the CSS as a measure of CRPS severity and suggests it may prove useful in clinical monitoring and outcomes research.

  20. Motor dysfunction of complex regional pain syndrome is related to impaired central processing of proprioceptive information.

    Science.gov (United States)

    Bank, Paulina J M; Peper, C Lieke E; Marinus, Johan; Beek, Peter J; van Hilten, Jacobus J

    2013-11-01

    Our understanding of proprioceptive deficits in complex regional pain syndrome (CRPS) and its potential contribution to impaired motor function is still limited. To gain more insight into these issues, we evaluated accuracy and precision of joint position sense over a range of flexion-extension angles of the wrist of the affected and unaffected sides in 25 chronic CRPS patients and in 50 healthy controls. The results revealed proprioceptive impairment at both the patients' affected and unaffected sides, characterized predominantly by overestimation of wrist extension angles. Precision of the position estimates was more prominently reduced at the affected side. Importantly, group differences in proprioceptive performance were observed not only for tests at identical percentages of each individual's range of wrist motion but also when controls were tested at wrist angles that corresponded to those of the patient's affected side. More severe motor impairment of the affected side was associated with poorer proprioceptive performance. Based on additional sensory tests, variations in proprioceptive performance over the range of wrist angles, and comparisons between active and passive displacements, the disturbances of proprioceptive performance most likely resulted from altered processing of afferent (and not efferent) information and its subsequent interpretation in the context of a distorted "body schema." The present results point at a significant role for impaired central processing of proprioceptive information in the motor dysfunction of CRPS and suggest that therapeutic strategies aimed at identification of proprioceptive impairments and their restoration may promote the recovery of motor function in CRPS patients. Copyright © 2013 American Pain Society. Published by Elsevier Inc. All rights reserved.

  1. Is physiotherapy effective for children with complex regional pain syndrome type 1?

    Science.gov (United States)

    Bialocerkowski, Andrea E; Daly, Anne

    2012-01-01

    This study synthesized current research evidence on the effectiveness of physiotherapy for the management of children diagnosed with complex regional pain syndrome type 1 (CRPS-1), to provide up-to-date physiotherapy treatment recommendations, and to identify areas that require further investigation. Nine electronic databases were searched for quantitative studies that evaluated the effect of physiotherapy on children with CRPS-1. The methodological quality of the studies was evaluated using the Critical Review Form. Data were extracted regarding the study design, participant characteristics, types of outcome measures used, and physiotherapy technique used and its effectiveness. The search strategy identified 303 potential studies, of which 12 met the inclusion criteria (1 randomized controlled trial, 1 comparative study, 10 case series). The methodological quality of all studies was rated as poor to fair. The "stand-alone" value of physiotherapy could not be determined as physiotherapy was prescribed in conjunction with psychological and medical interventions. There is low volume and poor-to-fair quality evidence which suggests that physiotherapy prescribed with other interventions may lead to short-term improvement in the signs and symptoms of CRPS-1 or functional ability in children with CRPS-1, and the relapse rate may be moderately high. High-quality studies are required in this area. These studies should evaluate a package of care (which includes physiotherapy); they should investigate the effects of physiotherapy treatments that have proven effectiveness in adults with CRPS-1; they should use psychometrically sound measures to evaluate outcome; and the nature of physiotherapy should be detailed in future publications to enable replication in the clinical setting.

  2. Changes in plasma cytokines and their soluble receptors in complex regional pain syndrome.

    Science.gov (United States)

    Alexander, Guillermo M; Peterlin, B Lee; Perreault, Marielle J; Grothusen, John R; Schwartzman, Robert J

    2012-01-01

    Complex Regional Pain Syndrome (CRPS) is a chronic and often disabling pain disorder. There is evidence demonstrating that neurogenic inflammation and activation of the immune system play a significant role in the pathophysiology of CRPS. This study evaluated the plasma levels of cytokines, chemokines, and their soluble receptors in 148 subjects afflicted with CRPS and in 60 gender- and age-matched healthy controls. Significant changes in plasma cytokines, chemokines, and their soluble receptors were found in subjects with CRPS as compared with healthy controls. For most analytes, these changes resulted from a distinct subset of the CRPS subjects. When the plasma data from the CRPS subjects was subjected to cluster analysis, it revealed 2 clusters within the CRPS population. The category identified as most important for cluster separation by the clustering algorithm was TNFα. Cluster 1 consisted of 64% of CRPS subjects and demonstrated analyte values similar to the healthy control individuals. Cluster 2 consisted of 36% of the CRPS subjects and demonstrated significantly elevated levels of most analytes and in addition, it showed that the increased plasma analyte levels in this cluster were correlated with disease duration and severity. The identification of biomarkers that define disease subgroups can be of great value in the design of specific therapies and of great benefit to the design of clinical trials. It may also aid in advancing our understanding of the mechanisms involved in the pathophysiology of CRPS, which may lead to novel treatments for this very severe condition. Copyright © 2012 American Pain Society. Published by Elsevier Inc. All rights reserved.

  3. Rational pain management in complex regional pain syndrome 1 (CRPS 1)--a network meta-analysis.

    Science.gov (United States)

    Wertli, Maria M; Kessels, Alphons G H; Perez, Roberto S G M; Bachmann, Lucas M; Brunner, Florian

    2014-09-01

    Guidelines for complex regional pain syndrome (CRPS) 1 advocate several substance classes to reduce pain and support physical rehabilitation, but guidance about which agent should be prioritized when designing a therapeutic regimen is not provided. Using a network meta-analytic approach, we examined the efficacy of all agent classes investigated in randomized clinical trials of CRPS 1 and provide a rank order of various substances stratified by length of illness duration. In this study a network meta-analysis was conducted. The participants of this study were patients with CRPS 1. Searches in electronic, previous systematic reviews, conference abstracts, book chapters, and the reference lists of relevant articles were performed. Eligible studies were randomized controlled trials comparing at least one analgesic agent with placebo or with another analgesic and reporting efficacy in reducing pain. Summary efficacy stratified by symptom duration and length of follow-up was computed across all substance classes. Two authors independently extracted data. In total, 16 studies were included in the analysis. Bisphosphonates appear to be the treatment of choice in early stages of CRPS 1. The effects of calcitonin surpass that of bisphosphonates and other substances as a short-term medication in more chronic stages of the illness. While most medications showed some efficacy on short-term follow-up, only bisphosphonates, NMDA analogs, and vasodilators showed better long-term pain reduction than placebo. For some drug classes, only a few studies were available and many studies included a small group of patients. Insufficient data were available to analyze efficacy on disability. This network meta-analysis indicates that a rational pharmacological treatment strategy of pain management should consider bisphosphonates in early CRPS 1 and a short-term course of calcitonin in later stages. While most medications showed some efficacy on short-term follow-up, only bisphosphonates

  4. Research on the development efficiency of regional high-end talent in China: A complex network approach.

    Science.gov (United States)

    Zhang, Zhen; Wang, Minggang; Tian, Lixin; Zhang, Wenbin

    2017-01-01

    In this paper, based on the panel data of 31 provinces and cities in China from 1991 to 2016, the regional development efficiency matrix of high-end talent is obtained by DEA method, and the matrix is converted into a continuous change of complex networks through the construction of sliding window. Using a series of continuous changes in the complex network topology statistics, the characteristics of regional high-end talent development efficiency system are analyzed. And the results show that the average development efficiency of high-end talent in the western region is at a low level. After 2005, the national regional high-end talent development efficiency network has both short-range relevance and long-range relevance in the evolution process. The central region plays an important intermediary role in the national regional high-end talent development system. And the western region has high clustering characteristics. With the implementation of the high-end talent policies with regional characteristics by different provinces and cities, the relevance of high-end talent development efficiency in various provinces and cities presents a weakening trend, and the geographical characteristics of high-end talent are more and more obvious.

  5. Extreme cosmos

    CERN Document Server

    Gaensler, Bryan

    2011-01-01

    The universe is all about extremes. Space has a temperature 270°C below freezing. Stars die in catastrophic supernova explosions a billion times brighter than the Sun. A black hole can generate 10 million trillion volts of electricity. And hypergiants are stars 2 billion kilometres across, larger than the orbit of Jupiter. Extreme Cosmos provides a stunning new view of the way the Universe works, seen through the lens of extremes: the fastest, hottest, heaviest, brightest, oldest, densest and even the loudest. This is an astronomy book that not only offers amazing facts and figures but also re

  6. Daily extreme temperature multifractals in Catalonia (NE Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Burgueño, A. [Departament d' Astronomia i Meteorologia, Universitat de Barcelona, Barcelona (Spain); Lana, X., E-mail: francisco.javier.lana@upc.edu [Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Barcelona (Spain); Serra, C. [Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Barcelona (Spain); Martínez, M.D. [Departament de Física Aplicada, Universitat Politècnica de Catalunya, Barcelona (Spain)

    2014-02-01

    The multifractal character of the daily extreme temperatures in Catalonia (NE Spain) is analyzed by means of the multifractal detrended fluctuation analysis (MF-DFA) applied to 65 thermometric records covering years 1950–2004. Although no clear spatial patterns of the multifractal spectrum parameters appear, factor scores deduced from Principal Component analysis indicate some signs of spatial gradients. Additionally, the daily extreme temperature series are classified depending on their complex time behavior, through four multifractal parameters (Hurst exponent, Hölder exponent with maximum spectrum, spectrum asymmetry and spectrum width). As a synthesis of the three last parameters, a basic measure of complexity is proposed through a normalized Complexity Index. Its regional behavior is found to be free of geographical dependences. This index represents a new step towards the description of the daily extreme temperatures complexity.

  7. Daily extreme temperature multifractals in Catalonia (NE Spain)

    International Nuclear Information System (INIS)

    Burgueño, A.; Lana, X.; Serra, C.; Martínez, M.D.

    2014-01-01

    The multifractal character of the daily extreme temperatures in Catalonia (NE Spain) is analyzed by means of the multifractal detrended fluctuation analysis (MF-DFA) applied to 65 thermometric records covering years 1950–2004. Although no clear spatial patterns of the multifractal spectrum parameters appear, factor scores deduced from Principal Component analysis indicate some signs of spatial gradients. Additionally, the daily extreme temperature series are classified depending on their complex time behavior, through four multifractal parameters (Hurst exponent, Hölder exponent with maximum spectrum, spectrum asymmetry and spectrum width). As a synthesis of the three last parameters, a basic measure of complexity is proposed through a normalized Complexity Index. Its regional behavior is found to be free of geographical dependences. This index represents a new step towards the description of the daily extreme temperatures complexity.

  8. Motor dysfunction in complex regional pain syndrome : the role of sensory processing and sensory-motor integration

    NARCIS (Netherlands)

    Bank, Paulina Johanna Maria

    2014-01-01

    In the chronic stage of Complex Regional Pain Syndrome (CRPS), motor disturbances are common and cause significant disability. The motor dysfunction of CRPS is a poorly understood phenomenon that is characterized predominantly by a decrease or loss of voluntary muscle control. This thesis aims to

  9. fMRI Reveals Distinct CNS Processing during Symptomatic and Recovered Complex Regional Pain Syndrome in Children

    Science.gov (United States)

    Lebel, A.; Becerra, L.; Wallin, D.; Moulton, E. A.; Morris, S.; Pendse, G.; Jasciewicz, J.; Stein, M.; Aiello-Lammens, M.; Grant, E.; Berde, C.; Borsook, D.

    2008-01-01

    Complex regional pain syndrome (CRPS) in paediatric patients is clinically distinct from the adult condition in which there is often complete resolution of its signs and symptoms within several months to a few years. The ability to compare the symptomatic and asymptomatic condition in the same individuals makes this population interesting for the…

  10. Investigating Reports of Complex Regional Pain Syndrome: An Analysis of HPV-16/18-Adjuvanted Vaccine Post-Licensure Data

    NARCIS (Netherlands)

    F.J.P.M. Huygen (Frank); K. Verschueren (Kristin); C. McCabe (Candida); J.-U. Stegmann (Jens-Ulrich); J. Zima (Julia); O. Mahaux (Olivia); L. Van Holle (Lionel); M.-G. Angelo (Maria-Genalin)

    2015-01-01

    textabstractComplex regional pain syndrome (CRPS) is a chronic pain disorder that typically follows trauma or surgery. Suspected CRPS reported after vaccination with human papillomavirus (HPV) vaccines led to temporary suspension of proactive recommendation of HPV vaccination in Japan. We

  11. Chronic pain and evoked responses in the brain: A magnetoencephalographic study in Complex Regional Pain Syndrome I and II

    NARCIS (Netherlands)

    Theuvenet, P.J.

    2012-01-01

    Complex Regional Pain Syndrome (CRPS) type I and II are chronic pain syndromes with comparable symptoms, only in CRPS II a peripheral nerve injury is present. No objective tests are currently available to differentiate the two types which hampers diagnosis and treatment. Non-invasive brain imaging

  12. How Discourses on Leisure Affect Regional Development in the Province of Fryslân : a Complex Adaptive Systems Perspective

    NARCIS (Netherlands)

    Meekes, Jasper; Parra Novoa, Constanza; de Roo, Gert

    2014-01-01

    Leisure is seen as an important factor for regional development in the province of Fryslân and many other predominantly rural and peripheral areas. However, planning for leisure, requiring high spatial quality, is a complex challenge. This is due to the fragmentation of leisure policy, but also to

  13. U-Pb age in zircon of intrusive granite at Acopiara complex, Crystal region, domain Central Ceara, Brazil

    International Nuclear Information System (INIS)

    Neri, T.F.O.; Hamelak, G.M.S.; Azevedo, L.R.; Mattos, I.C.; Verissimo, C.U.V.; Nogueira Neto, J.A.; Lima, M.N.

    2015-01-01

    Granitic body mineralogically composed by two micas, located at Crystal region, Ceara Central domain and intruded into lithotypes from Acopiara complex, provided an age of ∼526 Ma, indicating important period of magma generation of granitic composition associated with crustal anatexia, during Paleozoic

  14. Impact of spinal cord stimulation on sensory characteristics in complex regional pain syndrome type I - A randomized trial

    NARCIS (Netherlands)

    Kemler, MA; Reulen, JPH; Barendse, GAM; van Kleef, M; de Vet, HCW; van den Wildenberg, FAJM

    Background: A randomized trial was performed to assess the effect of spinal cord stimulation (SCS) on detection and pain thresholds for pressure, warmth, and cold and on the extent of mechanical hyperalgesia in patients with chronic complex regional pain syndrome type I. Methods: Fifty-four chronic

  15. Novel spin transition between S = 5/2 and S = 3/2 in highly saddled iron(III) porphyrin complexes at extremely low temperatures.

    Science.gov (United States)

    Ohgo, Yoshiki; Chiba, Yuya; Hashizume, Daisuke; Uekusa, Hidehiro; Ozeki, Tomoji; Nakamura, Mikio

    2006-05-14

    A novel spin transition between S = 5/2 and S = 3/2 has been observed for the first time in five-coordinate, highly saddled iron(III) porphyrinates by EPR and SQUID measurements at extremely low temperatures.

  16. Intravenous magnesium for chronic complex regional pain syndrome type 1 (CRPS-1).

    Science.gov (United States)

    Fischer, Sigrid G L; Collins, Susan; Boogaard, Sabine; Loer, Stephan A; Zuurmond, Wouter W A; Perez, Roberto S G M

    2013-09-01

    To assess the effects of intravenous administration of magnesium on complex regional pain syndrome type 1 (CRPS-1), a randomized double-blind placebo-controlled trial was performed. Fifty-six patients with CRPS-1 (International Association for the Study of Pain Orlando criteria) received MgSO(4) 70 mg/kg or placebo (NaCl 0.9%) in 4 hours over 5 consecutive days. Pain (BOX-11 and McGill), the level of impairment (Impairment level Sum Score [ISS]), functional limitations (Radboud Skills Questionnaire, Walking Skills Questionnaire/questionnaire rising and sitting down), participation (Impact on Participation and Autonomy [IPA]), and quality of life (Short Form-36, EuroQol, IPA) were evaluated at baseline and at 1, 3, 6, and 12 weeks. No significant differences were found between MgSO(4) and placebo on the BOX-11 and ISS at different time points during the trial on intention-to-treat and per-protocol analysis. A significant improvement on the BOX-11 was found after the first week of the trial in both groups (mean 0.7; standard deviation 1.1). For the MgSO(4) group, a clinically relevant and statistically significant improvement on the ISS at 1 week (median 5, interquartile range [IQR] -1 to 8) and a significant improvement on the McGill up to 6 weeks (median 2 words, IQR 0-4.5) were found compared with baseline, which were not found in the placebo group. Significant improvement in perceived job participation was found for the MgSO(4) group at 12 weeks (median improvement 1.44-1.17; P = 0.01). ISS improved significantly more in patients with a low Hospital Anxiety and Depression Scale (HADS) score (≤10) in the MgSO(4) group (mean 4.4 vs mean -3.1; P = 0.02). Administration of the physiological competitive N-methyl-D-aspartate receptor antagonist magnesium in chronic CRPS provides insufficient benefit over placebo. Future research should focus on patients with acute CRPS and early signs and symptoms of central sensitization. Wiley Periodicals, Inc.

  17. Prevalence and Cost Analysis of Complex Regional Pain Syndrome (CRPS): A Role for Neuromodulation.

    Science.gov (United States)

    Elsamadicy, Aladine A; Yang, Siyun; Sergesketter, Amanda R; Ashraf, Bilal; Charalambous, Lefko; Kemeny, Hanna; Ejikeme, Tiffany; Ren, Xinru; Pagadala, Promila; Parente, Beth; Xie, Jichun; Lad, Shivanand P

    2017-09-29

    The diagnosis and treatment of complex regional pain syndrome (CRPS) is challenging and there is a paucity of data describing its overall cost burden and quantifying its impact on the US healthcare system. The aim of this study was to assess the prevalence and healthcare utilization costs associated with CRPS. A retrospective longitudinal study was performed using the Truven MarketScan® database to identify patients with a new indexed diagnosis of CRPS (Type I, II, or both) from 2001 to 2012. We collected total, outpatient, and pain prescription costs three years prior to CRPS diagnosis (baseline), at year of CRPS diagnosis, and eight-year post-CRPS diagnosis. A longitudinal multivariate analysis was used to model the estimated total and pain prescription cost ratios comparing patients diagnosed before and after CRPS. We included 35,316 patients with a newly indexed diagnosis of CRPS (Type I: n = 18,703, Type II: n = 14,599, Unspecified: n = 2014). Baseline characteristics were similar between the CRPS cohorts. Compared to two- and three-year baseline costs, one-year prior to diagnosis for all CRPS patients yielded the highest interquartile median [IQR] costs: total costs $7904[$3469, $16,084]; outpatient costs $6706[$3119, $12,715]; and pain prescription costs $1862[$147, $7649]. At the year of CRPS diagnosis, the median [IQR] costs were significantly higher than baseline costs: total costs $8508[$3943, $16,666]; outpatient costs $7251[$3527, $13,568]; and pain prescription costs $2077[$140, $8856]. Over the eight-year period after CRPS diagnosis, costs between all the years were similar, ranging from the highest (one-year) to lowest (seven-years), $4845 to $3888. The median total cumulative cost 8-years after CRPS diagnosis was $43,026 and $12,037 for pain prescription costs. [Correction added on 06 November 2017 after first online publication: the preceding sentence has been updated to demonstrate the median cumulative cost in replacement of the

  18. Trying to Learn Lessons for Response to Extreme Events: Paradigm Shifts Affecting Civil Defense in the Trinational Region of Southwestern Amazonia

    Science.gov (United States)

    Santos, G. L. P.

    2015-12-01

    The last ten years have seen several extreme climate events in southwestern Amazonia with historic impacts. The City of Rio Branco, Capital of Acre, Brazil´s westernmost State, suffered its seventh consecutive annual flooding and its worst in March 2015. The city of Tarauacá, also in Acre, registered 12 flooding events between November 2014 and April 2015. The most recent flood of the trinational Acre River in 2015 set historic records for flood stage and number of displaced persons in Cobija, the Capital of Pando, Bolivia. From February to April 2014, floods of the Madeira River disrupted the one highway between Acre and southern Brazil. Puerto Maldonado, the capital in Madre de Dios Region of Peru had its worst flood in 50 years during 2014. In 2005 and 2010, prolonged droughts combined with ignition sources resulted in tens to hundreds of thousands of hectares of fire-damaged rainforests in the Madre de Dios, Acre and Pando (MAP) Region. The Civil Defenses in these three contiguous political units faced several abrupt paradigm shifts that affected their responses: 1) The drought of 2005 showed dramatically that regional rainforests do burn; 2) The recent flooding history, particularly in 2012 and 2015, demolished the cultural icon of a nine-year recurrence interval; 3) What happens outside your territory can be devastating. The Madeira River flood impeded an estimated 200 million dollars from circulating in Acre; 4) The past can be a terrible guide. For Cobija and Rio Branco, the 2015 flood was on the order of a meter higher than any other. Many home dwellers did not evacuate in time because they used past floods as a guide; 5) A collapse in communication - cell phones, land lines, and Internet - can get worse. In 2012, such a collapse occurred in two border towns for 5 days, yet in 2015 it lasted more than 11 days. Research is needed to address how institutions linked to Civil Defense can shift paradigms in time to be more effective.

  19. Investigating NARCCAP Precipitation Extremes via Bivariate Extreme Value Theory (Invited)

    Science.gov (United States)

    Weller, G. B.; Cooley, D. S.; Sain, S. R.; Bukovsky, M. S.; Mearns, L. O.

    2013-12-01

    We introduce methodology from statistical extreme value theory to examine the ability of reanalysis-drive regional climate models to simulate past daily precipitation extremes. Going beyond a comparison of summary statistics such as 20-year return values, we study whether the most extreme precipitation events produced by climate model simulations exhibit correspondence to the most extreme events seen in observational records. The extent of this correspondence is formulated via the statistical concept of tail dependence. We examine several case studies of extreme precipitation events simulated by the six models of the North American Regional Climate Change Assessment Program (NARCCAP) driven by NCEP reanalysis. It is found that the NARCCAP models generally reproduce daily winter precipitation extremes along the Pacific coast quite well; in contrast, simulation of past daily summer precipitation extremes in a central US region is poor. Some differences in the strength of extremal correspondence are seen in the central region between models which employ spectral nudging and those which do not. We demonstrate how these techniques may be used to draw a link between extreme precipitation events and large-scale atmospheric drivers, as well as to downscale extreme precipitation simulated by a future run of a regional climate model. Specifically, we examine potential future changes in the nature of extreme precipitation along the Pacific coast produced by the pineapple express (PE) phenomenon. A link between extreme precipitation events and a "PE Index" derived from North Pacific sea-surface pressure fields is found. This link is used to study PE-influenced extreme precipitation produced by a future-scenario climate model run.

  20. Regional differences in brain volume predict the acquisition of skill in a complex real-time strategy videogame.

    Science.gov (United States)

    Basak, Chandramallika; Voss, Michelle W; Erickson, Kirk I; Boot, Walter R; Kramer, Arthur F

    2011-08-01

    Previous studies have found that differences in brain volume among older adults predict performance in laboratory tasks of executive control, memory, and motor learning. In the present study we asked whether regional differences in brain volume as assessed by the application of a voxel-based morphometry technique on high resolution MRI would also be useful in predicting the acquisition of skill in complex tasks, such as strategy-based video games. Twenty older adults were trained for over 20 h to play Rise of Nations, a complex real-time strategy game. These adults showed substantial improvements over the training period in game performance. MRI scans obtained prior to training revealed that the volume of a number of brain regions, which have been previously associated with subsets of the trained skills, predicted a substantial amount of variance in learning on the complex game. Thus, regional differences in brain volume can predict learning in complex tasks that entail the use of a variety of perceptual, cognitive and motor processes. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Complex emergencies in the Eastern Mediterranean Region: Impact on tuberculosis control

    Directory of Open Access Journals (Sweden)

    Akihiro Seita

    2016-01-01

    Conclusion: Complex emergencies pose a significant negative impact on tuberculosis in the EMR. This issue should be raised in the global health and political arena. This is a time bomb for tuberculosis.

  2. Geology, petrology and geochronology of meridional and oriental regions of the Morungaba complex, SP

    International Nuclear Information System (INIS)

    Vlach, S.R.F.

    1985-01-01

    This work studies the Morungaba Intensive Complex, in Southwestern of Sao Paulo State. Formed principally by granitoid rocks with biotite. 31 granitoid facies with structural was recognized. Petrographic own characteristics. The rocks from Morungaba Complex was joint in three magmatics groups, denominated: Roby Gray and Porphyritic. Petrographic and mineralogical composition studies of this three groups were done. Geochranological studies by Rb/Sr and K/sr methods made possible to establish the ages and evolution of this rocks. This Complex formation and evolution are associated with the dioritic rocks presence. This work also concluded that the Morungaba Intrusive Complex represent the pos-orogenic wents from Brazilian Cycle. (C.D.G.) [pt

  3. Mediterranean land systems: Representing diversity and intensity of complex land systems in a dynamic region

    NARCIS (Netherlands)

    Malek, Ziga; Verburg, P.H.

    In the Mediterranean region, land systems have been shaped gradually through centuries. They provide services to a large and growing population in a region that is among the most vulnerable to future global change. The spatial extent and distribution of Mediterranean land systems is, however,

  4. The emerging architecture of a regional security complex in the Lake ...

    African Journals Online (AJOL)

    This article explores the emerging regional security architecture to fight terrorism and insurgency in the Lake Chad Basin (LCB). It diagnoses the evolution of the Lake Chad Basin Commission (LCBC) as a sub-regional organization that unites Chad, Cameroon, Niger and Nigeria. In particular, the article critically investigates ...

  5. THE HST EXTREME DEEP FIELD (XDF): COMBINING ALL ACS AND WFC3/IR DATA ON THE HUDF REGION INTO THE DEEPEST FIELD EVER

    International Nuclear Information System (INIS)

    Illingworth, G. D.; Magee, D.; Oesch, P. A.; Bouwens, R. J.; Labbé, I.; Franx, M.; Stiavelli, M.; Van Dokkum, P. G.; Trenti, M.; Carollo, C. M.; Gonzalez, V.

    2013-01-01

    The eXtreme Deep Field (XDF) combines data from 10 years of observations with the Hubble Space Telescope Advanced Camera for Surveys (ACS) and the Wide-Field Camera 3 Infra-Red (WFC3/IR) into the deepest image of the sky ever in the optical/near-IR. Since the initial observations of the Hubble Ultra-Deep Field (HUDF) in 2003, numerous surveys and programs, including supernovae follow-up, HUDF09, CANDELS, and HUDF12, have contributed additional imaging data across this region. However, these images have never been combined and made available as one complete ultra-deep image dataset. We combine them now with the XDF program. Our new and improved processing techniques provide higher quality reductions of the total dataset. All WFC3/IR and optical ACS data sets have been fully combined and accurately matched, resulting in the deepest imaging ever taken at these wavelengths, ranging from 29.1 to 30.3 AB mag (5σ in a 0.''35 diameter aperture) in 9 filters. The combined image therefore reaches to 31.2 AB mag 5σ (32.9 at 1σ) for a flat f ν source. The gains in the optical for the four filters done in the original ACS HUDF correspond to a typical improvement of 0.15 mag, with gains of 0.25 mag in the deepest areas. Such gains are equivalent to adding ∼130 to ∼240 orbits of ACS data to the HUDF. Improved processing alone results in a typical gain of ∼0.1 mag. Our 5σ (optical+near-IR) SExtractor catalogs reveal about 14,140 sources in the full field and about 7121 galaxies in the deepest part of the XDF

  6. Long-term comparison of the climate extremes variability in different climate types located in coastal and inland regions of Iran

    Science.gov (United States)

    Ghiami-Shamami, Fereshteh; Sabziparvar, Ali Akbar; Shinoda, Seirou

    2018-06-01

    The present study examined annually and seasonally trends in climate-based and location-based indices after detection of artificial change points and application of homogenization. Thirteen temperature and eight precipitation indices were generated at 27 meteorological stations over Iran during 1961-2012. The Mann-Kendall test and Sen's slope estimator were applied for trend detection. Results revealed that almost all indices based on minimum temperature followed warmer conditions. Indicators based on minimum temperature showed less consistency with more cold and less warm events. Climate-based results for all extremes indicated semi-arid climate had the most warming events. Moreover, based on location-based results, inland areas showed the most signs of warming. Indices based on precipitation exhibited a negative trend in warm seasons, with the most changes in coastal areas and inland, respectively. Results provided evidence of warming and drying since the 1990s. Changes in precipitation indices were much weaker and less spatially coherent. Summer was found to be the most sensitive season, in comparison with winter. For arid and semi-arid regions, by increasing the latitude, less warm events occurred, while increasing the longitude led to more warming events. Overall, Iran is dominated by a significant increase in warm events, especially minimum temperature-based indices (nighttime). This result, in addition to fewer precipitation events, suggests a generally dryer regime for the future, which is more evident in the warm season of semi-arid sites. The results could provide beneficial references for water resources and eco-environmental policymakers.

  7. Effector region of the translation elongation factor EF-Tu.GTP complex stabilizes an orthoester acid intermediate structure of aminoacyl-tRNA in a ternary complex.

    Science.gov (United States)

    Förster, C; Limmer, S; Zeidler, W; Sprinzl, M

    1994-01-01

    tRNA(Val) from Escherichia coli was aminoacylated with [1-13C]valine and its complex with Thermus thermophilus elongation factor EF-Tu.GTP was analyzed by 13C NMR spectroscopy. The results suggest that the aminoacyl residue of the valyl-tRNA in ternary complex with bacterial EF-Tu and GTP is not attached to tRNA by a regular ester bond to either a 2'- or 3'-hydroxyl group; instead, an intermediate orthoester acid structure with covalent linkage to both vicinal hydroxyls of the terminal adenosine-76 is formed. Mutation of arginine-59 located in the effector region of EF-Tu, a conserved residue in protein elongation factors and the alpha subunits of heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins), abolishes the stabilization of the orthoester acid structure of aminoacyl-tRNA. PMID:8183898

  8. Risk Factors for Post-treatment Complex Regional Pain Syndrome (CRPS): An Analysis of 647 Cases of CRPS from the Danish Patient Compensation Association.

    Science.gov (United States)

    Petersen, Pelle B; Mikkelsen, Kim L; Lauritzen, Jes B; Krogsgaard, Michael R

    2018-03-01

    Complex regional pain syndrome is a challenging condition that includes a broad spectrum of sensory, autonomic, and motor features predominantly in extremities recovering from a trauma. Few large-scale studies have addressed occurrence of and factors associated with complex regional pain syndrome (CRPS) following orthopedic treatment. The present study aimed to identify factors associated with post-treatment development of CRPS. Using the Danish Patient Compensation Association's database, we identified 647 patients claiming post-treatment CRPS between 1992 and 2015. Age, gender, initial diagnosis, treatment, and amount of compensation were extracted. Multivariate logistic regressions were performed to identify variables associated with approval of the claim. For carpal tunnel syndrome (CTS) patients, we registered whether symptoms were bilateral or unilateral and if neurophysiology prior to treatment was pathologic. The following ratios were found: women:men was 4:1, primary diagnosis to the upper limb:lower limb was 2.5:1, and surgical:nonsurgical treatment was 3:1. Mean age was 47.5 ± 13.7 years, and no intergender difference was detected. Antebrachial fracture (23%) and CTS (9%) were the most common primary conditions. Surgical treatment was associated with approval of the claim (odds ratio 3.5, 95% confidence interval 2.3 to 5.3; P CRPS patients. In CTS patients developing CRPS, normal neurophysiological examination findings were common, and it could be suspected that these patients were suffering from an pre-clinical stage of CRPS, not CTS. © 2017 World Institute of Pain.

  9. Renewable Resources: a national catalog of model projects. Volume 2. Mid-American Solar Energy Complex Region

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-07-01

    This compilation of diverse conservation and renewable energy projects across the United States was prepared through the enthusiastic participation of solar and alternate energy groups from every state and region. Compiled and edited by the Center for Renewable Resources, these projects reflect many levels of innovation and technical expertise. In many cases, a critique analysis is presented of how projects performed and of the institutional conditions associated with their success or failure. Some 2000 projects are included in this compilation; most have worked, some have not. Information about all is presented to aid learning from these experiences. The four volumes in this set are arranged in state sections by geographic region, coinciding with the four Regional Solar Energy Centers. The table of contents is organized by project category so that maximum cross-referencing may be obtained. This volume includes information on the Mid-American Solar Energy Complex Region. (WHK)

  10. [Complexity of care and organizational effectiveness: a survey among medical care units in nine Lombardy region hospitals].

    Science.gov (United States)

    Pasquali, Sara; Capitoni, Enrica; Tiraboschi, Giuseppina; Alborghetti, Adriana; De Luca, Giuseppe; Di Mauro, Stefania

    2017-01-01

    Eleven medical care units of nine Lombardy Region hospitals organized by levels of care model or by the traditional departmental model have been analyzed, in order to evaluate if methods for complexity of patient-care evaluation represent an index factor of nursing organizational effectiveness. Survey with nine Nurses in managerial position was conducted between Nov. 2013-Jan. 2014. The following factors have been described: context and nursing care model, staffing, complexity evaluation, patient satisfaction, staff well-being. Data were processed through Microsoft Excel. Among Units analysed ,all Units in levels of care and one organized by the departmental model systematically evaluate nursing complexity. Registered Nurses (RN) and Health Care Assistants (HCA) are on average numerically higher in Units that measure complexity (0.55/ 0.49 RN, 0.38/0.23 HCA - ratio per bed). Adopted measures in relation to changes in complexity are:rewarding systems, supporting interventions, such as moving personnel within different Units or additional required working hours; reduction in number of beds is adopted when no other solution is available. Patient satisfaction is evaluated through Customer Satisfaction questionnaires. Turnover, stress and rate of absenteeism data are not available in all Units. Complexity evaluation through appropriate methods is carried out in all hospitals organized in levels of care with personalized nursing care models, though complexity is detected with different methods. No significant differences in applied managerial strategies are present. Patient's satisfaction is evaluated everywhere. Data on staffing wellbeing is scarcely available. Coordinated regional actions are recommended in order to gather comparable data for research, improve decision making and effectiveness of Nursing care.

  11. Complex Regional Pain Syndrome (CRPS type-1) in an Adolescent Following Extravasation of Dextrose Containing Fluid-an Underdiagnosed Case.

    Science.gov (United States)

    Subedi, Asish; Bhattarai, Balkrishna; Biswas, Binay K; Khatiwada, Sindhu

    2011-06-01

    Due to its complex pathophysiology and wide spectrum of clinical manifestations, the diagnosis of CRPS is often missed in the early stage by primary care physicians. After being treated by a primary care physician for 5 months for chronic cellulitis, a 16-year-old girl was referred to our hospital with features of type-1 CRPS of the right upper extremity. Inability to diagnose early caused prolonged suffering to the girl with all the consequence of CRPS. The patient responded well with marked functional recovery from multimodal therapy. Ability to distinguish CRPS from other pain conditions, referral for specialty care at the appropriate time and full awareness of this condition and its clinical features among various healthcare professionals are essential in reducing patient suffering and stopping its progression towards difficult-to-treat situations.

  12. Solar and Stellar Active Regions:Cosmic laboratories for the study of Complexity

    OpenAIRE

    Vlahos, Loukas

    2008-01-01

    Solar active regions are driven dissipative dynamical systems. The turbulent convection zone forces new magnetic flux tubes to rise above the photosphere and shuffles the magnetic fields which are already above the photosphere. The driven 3D active region responds to the driver with the formation of Thin Current Sheets in all scales and releases impulsively energy, when special thresholds are met, on the form of nano-, micro-, flares and large scale coronal mass ejections. It has been documen...

  13. Effective management models and methods of economic educations in regional industrial complexes

    Directory of Open Access Journals (Sweden)

    Andrey Gennadyevich Butrin

    2014-06-01

    Full Text Available In the article, the methodical bases of management by the integrated industrial enterprises is developed according to the indicators of sustainable economic development of the region. The scope of the research is the region as the difficult mesosystem consisting of logistic clusters. The subject matter of the research is the organizational and economic relations developing in the course of interaction of participants of the regional economy as mesosystems. The models and methods of management by the large economic systems in the economy of the industrially developed region are developed; the organizational and economic essence of a logistic cluster as the subject of the regional economy us revealed. The mechanism of management by the integrated enterprises with using the cluster approach, technologies of logistics, management of supply chains is offered. They allow to the management of an enterprises to make scientifically reasonable effective decisions developing programs of supply, economic production and realization of finished goods in the close connection with programs of regional economic development.

  14. Badass gullies: Fluvio-mass-movement gully complexes in New Zealand's East Coast region, and potential for remediation

    Science.gov (United States)

    Marden, Michael; Fuller, Ian C.; Herzig, Alexander; Betts, Harley D.

    2018-04-01

    This paper reviews gully erosion in the East Coast region of New Zealand's North Island and conceptualises fluvio-mass-movement gully complexes as badass gully systems. Tectonic setting and lithological control, with steep slopes and a climate influenced by tropical cyclones, predispose hill country in the East Coast region to gully erosion. The clearance of indigenous forest since the late 1800s has dramatically increased catchment erosion and paved the way for development of large-scale fluvio-mass-movement gully complexes. These features are a composite of