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Sample records for experiments involving correlated

  1. Sensitivity improvement for correlations involving arginine side-chain Nε/Hε resonances in multi-dimensional NMR experiments using broadband 15N 180o pulses

    International Nuclear Information System (INIS)

    Iwahara, Junji; Clore, G. Marius

    2006-01-01

    Due to practical limitations in available 15 N rf field strength, imperfections in 15 N 180 o pulses arising from off-resonance effects can result in significant sensitivity loss, even if the chemical shift offset is relatively small. Indeed, in multi-dimensional NMR experiments optimized for protein backbone amide groups, cross-peaks arising from the Arg guanidino 15 Nε (∼85 ppm) are highly attenuated by the presence of multiple INEPT transfer steps. To improve the sensitivity for correlations involving Arg Nε-Hε groups, we have incorporated 15 N broadband 180 deg. pulses into 3D 15 N-separated NOE-HSQC and HNCACB experiments. Two 15 N-WURST pulses incorporated at the INEPT transfer steps of the 3D 15 N-separated NOE-HSQC pulse sequence resulted in a ∼1.5-fold increase in sensitivity for the Arg Nε-Hε signals at 800 MHz. For the 3D HNCACB experiment, five 15 N Abramovich-Vega pulses were incorporated for broadband inversion and refocusing, and the sensitivity of Arg 1 Hε- 15 Nε- 13 Cγ/ 13 Cδ correlation peaks was enhanced by a factor of ∼1.7 at 500 MHz. These experiments eliminate the necessity for additional experiments to assign Arg 1 Hε and 15 Nε resonances. In addition, the increased sensitivity afforded for the detection of NOE cross-peaks involving correlations with the 15 Nε/ 1 Hε of Arg in 3D 15 N-separated NOE experiments should prove to be very useful for structural analysis of interactions involving Arg side-chains

  2. The isotope correlation experiment

    International Nuclear Information System (INIS)

    Koch, L.; Schoof, S.

    1983-01-01

    The ESARDA working group on Isotopic Correlation Techniques, ICT and Reprocessing Input Analysis performed an Isotope Correlation Experiment, ICE with the aim to check the feasibility of the new technique. Ten input batches of the reprocessing of the KWO fuel at the WAK plant were analysed by 4 laboratories. All information to compare ICT with the gravimetric and volumetric methods was available. ICT combined with simplified reactor physics calculation was included. The main objectives of the statistical data evaluation were detection of outliers, the estimation of random errors and of systematic errors of the measurements performed by the 4 laboratories. Different methods for outlier detection, analysis of variances, Grubbs' analysis for the constant-bias model and Jaech's non-constant-bias model were applied. Some of the results of the statistical analysis may seem inconsistent which is due to the following reasons. For the statistical evaluations isotope abundance data (weight percent) as well as nuclear concentration data (atoms/initial metal atoms) were subjected to different outlier criteria before being used for further statistical evaluations. None of the four data evaluation groups performed a complete statistical data analysis which would render possible a comparison of the different methods applied since no commonly agreed statistical evaluation procedure existed. The results prove that ICT is as accurate as conventional techniques which have to rely on costly mass spectrometric isotope dilution analysis. The potential of outlier detection by ICT on the basis of the results from a single laboratory is as good as outlier detection by costly interlaboratory comparison. The application of fission product or Cm-244 correlations would be more timely than remeasurements at safeguards laboratories

  3. Quantum correlations in connected multipartite Bell experiments

    International Nuclear Information System (INIS)

    Tavakoli, Armin

    2016-01-01

    Bell experiments measure correlations between outcomes of a number of observers measuring on a shared physical state emitted from a single source. Quantum correlations arising in such Bell experiments have been intensively studied over the last decades. Much less is known about the nature of quantum correlations arising in network structures beyond Bell experiments. Such networks can involve many independent sources emitting states to observers in accordance with the network configuration. Here, we will study classical and quantum correlations in a family of networks which can be regarded as compositions of several independent multipartite Bell experiments connected together through a central node. For such networks we present tight Bell-type inequalities which are satisfied by all classical correlations. We study properties of the violations of our inequalities by probability distributions arising in quantum theory. (paper)

  4. 4π detector for correlation experiments

    International Nuclear Information System (INIS)

    Thorndike, A.M.

    1975-01-01

    A conceptual design of a 4π detector for ISA-BELLE involves a counter hodoscope with 302 elements and an array of proportional wire chambers with 8950 wires. Such a detector could be used for correlation experiments and measurements of total cross section, as has been done by the Pisa-Stony Brook group at the ISR. (U.S.)

  5. Sensitivity improvement for correlations involving arginine side-chain N{epsilon}/H{epsilon} resonances in multi-dimensional NMR experiments using broadband {sup 15}N 180{sup o} pulses

    Energy Technology Data Exchange (ETDEWEB)

    Iwahara, Junji; Clore, G. Marius [National Institutes of Health, Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Disease (United States)], E-mail: mariusc@intra.niddk.nih.gov

    2006-12-15

    Due to practical limitations in available {sup 15}N rf field strength, imperfections in {sup 15}N 180{sup o} pulses arising from off-resonance effects can result in significant sensitivity loss, even if the chemical shift offset is relatively small. Indeed, in multi-dimensional NMR experiments optimized for protein backbone amide groups, cross-peaks arising from the Arg guanidino {sup 15}N{epsilon} ({approx}85 ppm) are highly attenuated by the presence of multiple INEPT transfer steps. To improve the sensitivity for correlations involving Arg N{epsilon}-H{epsilon} groups, we have incorporated {sup 15}N broadband 180 deg. pulses into 3D {sup 15}N-separated NOE-HSQC and HNCACB experiments. Two {sup 15}N-WURST pulses incorporated at the INEPT transfer steps of the 3D {sup 15}N-separated NOE-HSQC pulse sequence resulted in a {approx}1.5-fold increase in sensitivity for the Arg N{epsilon}-H{epsilon} signals at 800 MHz. For the 3D HNCACB experiment, five {sup 15}N Abramovich-Vega pulses were incorporated for broadband inversion and refocusing, and the sensitivity of Arg{sup 1}H{epsilon}-{sup 15}N{epsilon}-{sup 13}C{gamma}/{sup 13}C{delta} correlation peaks was enhanced by a factor of {approx}1.7 at 500 MHz. These experiments eliminate the necessity for additional experiments to assign Arg {sup 1}H{epsilon} and {sup 15}N{epsilon} resonances. In addition, the increased sensitivity afforded for the detection of NOE cross-peaks involving correlations with the {sup 15}N{epsilon}/{sup 1}H{epsilon} of Arg in 3D {sup 15}N-separated NOE experiments should prove to be very useful for structural analysis of interactions involving Arg side-chains.

  6. The energy-time uncertainty principle and the EPR paradox: Experiments involving correlated two-photon emission in parametric down-conversion

    Science.gov (United States)

    Chiao, Raymond Y.; Kwiat, Paul G.; Steinberg, Aephraim M.

    1992-01-01

    The energy-time uncertainty principle is on a different footing than the momentum position uncertainty principle: in contrast to position, time is a c-number parameter, and not an operator. As Aharonov and Bohm have pointed out, this leads to different interpretations of the two uncertainty principles. In particular, one must distinguish between an inner and an outer time in the definition of the spread in time, delta t. It is the inner time which enters the energy-time uncertainty principle. We have checked this by means of a correlated two-photon light source in which the individual energies of the two photons are broad in spectra, but in which their sum is sharp. In other words, the pair of photons is in an entangled state of energy. By passing one member of the photon pair through a filter with width delta E, it is observed that the other member's wave packet collapses upon coincidence detection to a duration delta t, such that delta E(delta t) is approximately equal to planks constant/2 pi, where this duration delta t is an inner time, in the sense of Aharonov and Bohm. We have measured delta t by means of a Michelson interferometer by monitoring the visibility of the fringes seen in coincidence detection. This is a nonlocal effect, in the sense that the two photons are far away from each other when the collapse occurs. We have excluded classical-wave explanations of this effect by means of triple coincidence measurements in conjunction with a beam splitter which follows the Michelson interferometer. Since Bell's inequalities are known to be violated, we believe that it is also incorrect to interpret this experimental outcome as if energy were a local hidden variable, i.e., as if each photon, viewed as a particle, possessed some definite but unknown energy before its detection.

  7. Childhood AIDS: pulmonary involvement. Clinico radiological correlation

    International Nuclear Information System (INIS)

    Cinta, C.; Muro, D.; Perez, A.; Otero, M.C.

    1997-01-01

    To determine the different radiological findings in the lung of children presenting human ummunodeficiency virus (HIV) infection. We assess the different radiological patterns and their prevalence. The study deals with 58 children presenting HIV infection. All underwent plain chest radiography at some time during the course of their disease to determine the cause of different respiratory symptoms (dyspnea, fever, cough, etc.).Bronchial lavage was performed in all the children who required intubation due to severe respiratory distress. The results of chest X-ray were normal in 29 children despite the existence of pulmonary symptomatology. The other 29 patients presented pulmonary, including 21 cases of pneumonia (36,2%) in 16 patients, in seven of whom the pathogen was determined by blood culture. Four cases of Pneumocystis carinii (6.89%) were diagnosed by means of bronchial lavage. There were nine children with interstitial pneumonitis, five of the lym-phoid variant (8.62%) and four of unknown origin (6.89%). In contrast to the findings in adults, we have had no cases of pulmonary tuberculosis among our patients The rates of morbidity and mortality among HIV-infected children are associated with lung involvement. However, the prevalence has decreased progressively since the introduction of antiviral agents. Recurrent bacterial pneumonia and opportunistic Pneumocystis carinii infection are the most common types of acute pulmonary involvement. Interstitial pneumonitis usually develops a chronic course. (Author) 15 refs

  8. Some techniques of correlation experiments

    International Nuclear Information System (INIS)

    Allas, R.G.

    1976-01-01

    Some general remarks concerning correlation techniques are made. Most of the remarks are limited to correlated pairs of charged particles. The relatively simple system 3 He + 3 H → A + B + C, where all possible charged particle pairs A,B are detected and particle C is left undetected either charged or neutral, is considered. (G.T.H.)

  9. Noise correlations in cosmic microwave background experiments

    Science.gov (United States)

    Dodelson, Scott; Kosowsky, Arthur; Myers, Steven T.

    1995-01-01

    Many analysis of microwave background experiments neglect the correlation of noise in different frequency of polarization channels. We show that these correlations, should they be present, can lead to serve misinterpretation of an experiment. In particular, correlated noise arising from either electronics or atmosphere may mimic a cosmic signal. We quantify how the likelihood function for a given experiment varies with noise correlation, using both simple analytic models and actual data. For a typical microwave background anisotropy experiment, noise correlations at the level of 1% of the overall noise can seriously reduce the significance of a given detection.

  10. Inequalities for nonideal correlation experiments

    International Nuclear Information System (INIS)

    Fine, A.

    1991-01-01

    This paper addresses the inefficiency loophole in the Bell theorem. The author examines factorizable stochastic models for the Bell inequalities, where they allow the detection efficiency to depend both on the hidden state of the measured system and also its passage through an analyzer. They show that, nevertheless, if the efficiency functions are symmetric between the two wings of the experiment, one can dispense with supplementary assumptions and derive new inequalities that enable the models to be tested even for highly inefficient experiments

  11. Involving Motion Graphics in Spatial Experience Design

    DEFF Research Database (Denmark)

    Steijn, Arthur

    2013-01-01

    elements such as e.g. space, tone, color, movement, time and timing. Developing this design model has two purposes. The first is as a tool for analyzing empirical examples or cases of where motion graphics is used in spatial experience design. The second is as a tool that can be used in the actual design...... process, and therefore it should be constructed as such. Since the development of the design model has this double focus, I involve design students in design laboratories related to my practice as a teacher in visual communication design and production design. I also reflect on how an initial design...

  12. Recent Experiments Involving Few-Nucleon Systems

    Science.gov (United States)

    Tornow, W.

    2014-08-01

    Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations.

  13. Recent Experiments Involving Few-Nucleon Systems

    International Nuclear Information System (INIS)

    Tornow, W.

    2014-01-01

    Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations. (author)

  14. Recent experiments involving highly excited atoms

    International Nuclear Information System (INIS)

    Latimer, C.J.

    1979-01-01

    Very large and fragile atoms may be produced by exciting normal atoms with light or by collisions with other atomic particles. Atoms as large as 10 -6 m are now routinely produced in the laboratory and their properties studied. In this review some of the simpler experimental methods available for the production and detection of such atoms are described including tunable dye laser-excitation and field ionization. A few recent experiments which illustrate the collision properties and the effects of electric and and magnetic fields are also described. The relevance of highly excited atoms in other areas of research including radioastronomy and isotope separation are discussed. (author)

  15. psycho-social correlates of students' involvement in secret cults

    African Journals Online (AJOL)

    PROF EKWUEME

    as constituting general threat to peace in institutions of higher learning. (Fawole ... involvement in secret cults, and to investigate if peer group do influence students involvement in secret cults. .... be of benefit to students, teachers, parents,.

  16. Parental Childrearing Attitudes as Correlates of Father Involvement during Infancy

    Science.gov (United States)

    Gaertner, Bridget M.; Spinrad, Tracy L.; Eisenberg, Nancy; Greving, Karissa A.

    2007-01-01

    Using daily diary data to document involvement with infants at 6-8 months of age (n = 142) and 6 months later (n = 95), we examined relations between reported childrearing attitudes and resident fathers' relative (as compared to mothers') involvement with children. Fathers' authoritarian views related negatively to their relative involvement on…

  17. Parental Childrearing Attitudes as Correlates of Father Involvement During Infancy

    OpenAIRE

    Gaertner, Bridget M.; Spinrad, Tracy L.; Eisenberg, Nancy; Greving, Karissa A.

    2007-01-01

    Using daily diary data to document involvement with infants at 6 – 8 months of age (n = 142) and 6 months later (n = 95), we examined relations between reported childrearing attitudes and resident fathers' relative (as compared to mothers') involvement with children. Fathers' authoritarian views related negatively to their relative involvement on weekdays, and this relation held over time for caregiving and playing activities. Mothers' protective attitudes had concurrent negative associations...

  18. Modeling of modification experiments involving neutral-gas release

    International Nuclear Information System (INIS)

    Bernhardt, P.A.

    1983-01-01

    Many experiments involve the injection of neutral gases into the upper atmosphere. Examples are critical velocity experiments, MHD wave generation, ionospheric hole production, plasma striation formation, and ion tracing. Many of these experiments are discussed in other sessions of the Active Experiments Conference. This paper limits its discussion to: (1) the modeling of the neutral gas dynamics after injection, (2) subsequent formation of ionosphere holes, and (3) use of such holes as experimental tools

  19. Father Involvement: Attitudinal and Personality Correlates for College Women.

    Science.gov (United States)

    Makosky, Vivian Parker; Roeding, Ginna M.

    Although parental effects on the personality development of children have been well examined, fathers' influence and effects on older children have received little attention. To investigate fathers' involvement in the attitude and personality development of college women, 333 women, ages 18 to 23, completed a three-part questionnaire gathering…

  20. Prostate cancer patients’ experience of involvement in decision-making

    DEFF Research Database (Denmark)

    Løwe Netsey-Afedo, Mette Margrethe; Birkelund, Regner

    2016-01-01

    experiences of being involved in the course of their disease and whether they experience being informed in a relevant way. In Denmark this area remains under investigated. Patient satisfaction, treatment results and patient safety can be improved if patients are involved in decision-making concerning...... sufficiently informed. Method: This study is based on qualitative semi-structured life-world interviews of 6 prostate cancer patients. The interviews were carried out in the participants’ homes during March and April 2014. The interpretation of the data is based on Paul Ricoeur’s phenomenological...

  1. Parents involvement in cyber bullying experience of middle school students

    OpenAIRE

    Hrnčić, Jasna; Lončar, Nina

    2017-01-01

    Cyber bullying has been widespread among youth during the last few decades, sometimes with deadly consequences. This type of violence remains too often out of adult's control since for many parents and teachers Internet and social media still represent an unknown territory. The objective of the current study is the analysis of the scope of parental involvement in children's online experience and their peer cyber bullying experience, and the analysis of connection between these two phenomena. ...

  2. Musical Imagery Involves Wernicke's Area in Bilateral and Anti-Correlated Network Interactions in Musicians.

    Science.gov (United States)

    Zhang, Yizhen; Chen, Gang; Wen, Haiguang; Lu, Kun-Han; Liu, Zhongming

    2017-12-06

    Musical imagery is the human experience of imagining music without actually hearing it. The neural basis of this mental ability is unclear, especially for musicians capable of engaging in accurate and vivid musical imagery. Here, we created a visualization of an 8-minute symphony as a silent movie and used it as real-time cue for musicians to continuously imagine the music for repeated and synchronized sessions during functional magnetic resonance imaging (fMRI). The activations and networks evoked by musical imagery were compared with those elicited by the subjects directly listening to the same music. Musical imagery and musical perception resulted in overlapping activations at the anterolateral belt and Wernicke's area, where the responses were correlated with the auditory features of the music. Whereas Wernicke's area interacted within the intrinsic auditory network during musical perception, it was involved in much more complex networks during musical imagery, showing positive correlations with the dorsal attention network and the motor-control network and negative correlations with the default-mode network. Our results highlight the important role of Wernicke's area in forming vivid musical imagery through bilateral and anti-correlated network interactions, challenging the conventional view of segregated and lateralized processing of music versus language.

  3. Public involvement in the decision making process, Argentine experience

    International Nuclear Information System (INIS)

    Clein, D.

    1999-01-01

    In the frame of a young participative democracy the Comision Nacional de Energia Atomica (C.N.E.A.), technical and legal responsible for radioactive waste management, is developing a plan for the close out of tailings facilities from past mining and milling operations and the environmental restoration of nine different sites in six provinces all over the country. In the first site, Malargue Facility, different activities have been developed promoting public involvement in the decision making process. The lessons learned and the experience acquired have given the background for the systematization of public consultation in the ongoing and future stages of the plan. Malargue's experience in this field will be analyzed stressing on different aspects considered of importance for the design of a communicational strategy adapted to the characteristics of a society without experience in this field. The influence of public concern on conservative bias of technical decisions will be evaluated. (author)

  4. Psychological characteristics of systemic sclerosis patients and their correlation with major organ involvement and disease activity.

    Science.gov (United States)

    Golemati, Christina V; Moutsopoulos, Haralampos M; Vlachoyiannopoulos, Panayiotis G

    2013-01-01

    The aim of this paper is to assess the psychological characteristics of personality, depression, anxiety, social support and coping strategies of systemic sclerosis (SSc) patients, their inter-correlations and their association with clinical symptoms. Patients with SSc (n=85) were interviewed and compared to rheumatoid arthritis (RA) patients (n=120) and healthy controls (HCs [n=125]). Psychological characteristics were assessed by the following psychometric scales: centre of epidemiological studies of depression (CES-D), hospital anxiety and depression scale (HAD), Eysenck personality questionnaire (EPQ), short form of social support (SSq), life experiences survey (LES) and ways of coping (WoC). Clinical data were collected at the same time of the interview. Both control groups were matched to SSc patients in terms of gender, age and educational status. Data were analysed with SPSS software. Compared to control groups, SSc patients expressed more symptoms of depression and anxiety, showed less extraversion and reported more negative life events. They coped less often with positive reappraisal, problem solving, seeking of support and assertiveness, while they sought more often divine help, and they expressed wishing and denial. Inactive disease was associated with a lower probability of reporting depressive symptoms and negative life events and with a higher probability of positively reevaluating a problem. Lung dysfunction, skin involvement, esophageal problems and oral aperture correlated with psychological features. Complications in psychological well-being characterise patients with SSc. This finding, as well as that of psychological characteristics correlating with organic factors, is an indication for designing supportive psycho-educational programmes as complementary therapies.

  5. The experience of mathematical beauty and its neural correlates

    Science.gov (United States)

    Zeki, Semir; Romaya, John Paul; Benincasa, Dionigi M. T.; Atiyah, Michael F.

    2014-01-01

    Many have written of the experience of mathematical beauty as being comparable to that derived from the greatest art. This makes it interesting to learn whether the experience of beauty derived from such a highly intellectual and abstract source as mathematics correlates with activity in the same part of the emotional brain as that derived from more sensory, perceptually based, sources. To determine this, we used functional magnetic resonance imaging (fMRI) to image the activity in the brains of 15 mathematicians when they viewed mathematical formulae which they had individually rated as beautiful, indifferent or ugly. Results showed that the experience of mathematical beauty correlates parametrically with activity in the same part of the emotional brain, namely field A1 of the medial orbito-frontal cortex (mOFC), as the experience of beauty derived from other sources. PMID:24592230

  6. Factors influencing first-time fathers' involvement in their wives' pregnancy and childbirth: A correlational study.

    Science.gov (United States)

    Xue, Weilin Lynn; He, Hong-Gu; Chua, Ying Jie; Wang, Wenru; Shorey, Shefaly

    2018-03-20

    To examine factors influencing first-time fathers' involvement in their wives' pregnancy and childbirth in Singapore. A cross-sectional descriptive correlational study was conducted in a public tertiary hospital in Singapore. A total of 182 first-time fathers whose wives were hospitalized at four obstetric wards were recruited from November 2015 to January 2016. Data were collected by three newly developed and validated instruments, namely Father's Involvement in Pregnancy and Childbirth, Father's Informational and Sources of Support, and Father's Attitude Towards Involvement in Pregnancy and Childbirth, as well as the 16-item Couple Satisfaction Index and Family of Origin Questionnaire. The participants were generally involved in their wives' pregnancy and childbirth, with 35.2% being highly involved. There was no significant difference in fathers' levels of involvement between or among any sociodemographic subgroups. Significant Spearman's correlations were found between fathers' levels of involvement and levels of informational support as well as fathers' attitudes towards involvement. However, the logistic regression showed the level of informational support was the only significant factor that influenced first-time fathers' high levels of involvement in their wives' pregnancy and childbirth. The study revealed the importance of providing sufficient informational support to first-time fathers so that they can be highly involved in their wife's pregnancy and childbirth. Future studies can develop technology-based intervention programmes to improve fathers' involvement in their wife's pregnancy and childbirth. Healthcare professionals should examine and improve the existing informational support for first-time fathers and ensure its relevance and convenient access. Copyright © 2018 Elsevier Ltd. All rights reserved.

  7. Trends and correlates of cannabis-involved emergency department visits: 2004 to 2011

    Science.gov (United States)

    Zhu, He; Wu, Li-Tzy

    2016-01-01

    Objectives To examine trends and correlates of cannabis-involved emergency department (ED) visits in the United States from 2004 to 2011. Methods Data were obtained from the 2004-2011 Drug Abuse Warning Network. We analyzed trend in cannabis-involved ED visits for persons aged ≥12 years and stratified by type of cannabis involvement (cannabis-only, cannabis-polydrug). We used logistic regressions to determine correlates of cannabis-involved hospitalization versus cannabis-involved ED visits only. Results Between 2004 and 2011, the ED visit rate increased from 51 to 73 visits per 100,000 population aged ≥ 12 years for cannabis-only use (P-value for trend=0.004) and from 63 to 100 for cannabis-polydrug use (P-value for trendcannabis-only-involved ED visit rate (Rate difference=80 per 100,000 adolescents). Across racial/ethnic groups, the most prevalent ED visits were noted among non-Hispanic blacks. Among cannabis-involved visits, the odds of hospitalization (versus ED visits only) increased with age strata compared with aged 12-17 years. Conclusions These findings suggest a notable increase in the ED visit numbers and rates for both the use of cannabis-only and cannabis-polydrug during the studied period, particularly among young people and non-Hispanic blacks. PMID:27574753

  8. First example of a high-level correlated calculation of the indirect spin-spin coupling constants involving tellurium

    DEFF Research Database (Denmark)

    Rusakov, Yury Yu; Krivdin, Leonid B.; Østerstrøm, Freja From

    2013-01-01

    This paper documents a very first example of a high-level correlated calculation of spin-spin coupling constants involving tellurium taking into account relativistic effects, vibrational corrections and solvent effects for the medium sized organotellurium molecules. The 125Te-1H spin-spin coupling...... constants of tellurophene and divinyl telluride were calculated at the SOPPA and DFT levels in a good agreement with experiment. A new full-electron basis set av3z-J for tellurium derived from the "relativistic" Dyall's basis set, dyall.av3z, and specifically optimized for the correlated calculations...... of spin-spin coupling constants involving tellurium, was developed. The SOPPA methods show much better performance as compared to 15 those of DFT, if relativistic effects calculated within the ZORA scheme are taken into account. Vibrational and solvent corrections are next to negligible, while...

  9. Correlates of New Graduate Nurses' Experiences of Workplace Mistreatment.

    Science.gov (United States)

    Read, Emily; Laschinger, Heather K

    2015-10-01

    This study explores correlates of new graduate nurses’ experiences of workplace mistreatment. New graduate nurses’ experiences of workplace mistreatment, such as bullying, coworker incivility, and supervisor incivility, negatively influence nurses’ work and health. It is unclear whether these forms of workplace mistreatment have similar precipitating factors and outcomes. We surveyed 342 new graduate nurses in Ontario to explore correlates of 3 forms of workplace mistreatment. Workplace incivility and bullying were significantly related to authentic leadership, structural empowerment, worklife fit, and psychological capital. Bullying was more strongly related to job satisfaction, emotional exhaustion, and mental and physical health outcomes than supervisor and coworker incivility. New graduate nurses’ experiences of 3 types of workplace mistreatment are related to organizational and health factors, although bullying appears to have stronger negative effects.

  10. Nailfold capillaroscopy abnormalities correlate with cutaneous and visceral involvement in systemic sclerosis patients.

    Science.gov (United States)

    Sato, Lucy T; Kayser, Cristiane; Andrade, Luís E C

    2009-01-01

    The aim of this study was to correlate quantitative and semiquantitative nailfold capillaroscopy (NFC) parameters with the extent of cutaneous and visceral involvement in systemic sclerosis (SSc) patients. The presence of clinical and serological alterations was evaluated retrospectively and correlated with NFC findings (number of capillary loops/mm, vascular deletion score and number of enlarged and giant capillary loops). For evaluation of disease extension five manifestations were analyzed: finger pad lesions, skin involvement, esophageal involvement, interstitial lung disease, and pulmonary hypertension. There were 105 NFC examinations in 92 patients, 13 of whom were evaluated at two different time points. Patients with diffuse cutaneous SSc had a higher vascular deletion score than patients with limited cutaneous SSc, sine scleroderma SSc, and overlap syndrome (1.67+/-0.91 vs 0.99+/-0.82; p=0.0005). Modified Rodnan's skin score correlated positively with capillary deletion, evaluated by the vascular deletion score and the number of capillary loops/mm (p<0.001 and p=0.012; respectively). Patients with three or more involved tracts presented lower number of capillary loops/mm (8.00+/-1.69 vs 9.23+/-1.31 capillary loops/mm; p=0.025) and a higher vascular deletion score (1.41+/-0.95 vs 0.73+/-0.76; p=0.027) when compared to patients with less than three affected tracts. Vascular deletion score was significantly higher in patients with anti-Scl-70 antibodies that in patients without anti-Scl-70 antibodies (p=0.02). NFC abnormalities correlated positively with the diffuse form of SSc, the degree of cutaneous involvement, the number of affected tracts, and the presence of anti-Scl-70 antibodies.

  11. CT assessment of the correlation between clinical examination and bone involvement in oral malignant tumors

    International Nuclear Information System (INIS)

    Albuquerque, Marco Antonio Portela; Oliveira, Ilka Regina Souza; Cavalcanti, Marcelo Gusmao Paraiso; Kuruoshi, Marcia Etsuko

    2009-01-01

    Oral cancers have a tendency to invade the surrounding bone structures, and this has a direct influence on the treatment management and on outcomes. The objective of this study was to correlate the clinical parameters (location, clinical presentation and TNM staging) of oral malignant tumors that can be associated with a potential of bone invasion and determine the accuracy of clinical examination to predict bone involvement, using computed tomography (CT). Twenty five patients, with oral malignant tumors were submitted to clinical and CT examinations. CT was considered the standard parameter to evaluate the presence of bone involvement. Clinical assessment of location, presentation form and TNM staging of the tumors were then compared to the CT findings in predicting bone involvement. Bone involvement was observed in 68% of the cases. It was predicted that tumors located in the retromolar trigone and hard palate, with a clinical aspect of infiltrative ulcer or nodule and classified in stage IV had a high potential to cause bone involvement. The clinical examination assessment of these tumors showed to be a valuable tool to predict bone invasion, with high sensitivity (82%) and specificity (87.5%), based on the results found in the CT images. No statistical significance was found between the CT and clinical examinations regarding bone involvement. The identification of some clinical parameters such as location, clinical presentation, and TNM stage, associated with a detailed clinical examination, was considered a valuable tool for the assessment of bone destruction by oral malignant tumors. (author)

  12. Correlation between clinical and radiographic findings on the occurrence of furcation involvement in patients with periodontitis.

    Science.gov (United States)

    Gusmão, Estela Santos; Picarte, Ana Carolina Lessa Cavalcanti; Ben Barbosa, Maria Bernadete Cavalcanti; Rösing, Cassiano Kuchenbecker; Cimoes, Renata

    2014-01-01

    Aim : The aim of the present study was to determine the occurrence of furcation involvement in the molars of patients with chronic periodontitis and correlate clinical and radiographic findings. Seventy subjects aged 35-69 years enrolled for treatment at a periodontics specialization program in Pernambuco, Brazil (EAP-SCDP-ABO/PE) participated in the study, comprising a total of 350 molars examined. The clinical diagnosis of furcation involvement was performed with a horizontal Nabers probe, whereas the radiographic examination was performed with periapical and bite-wing radiographs. The images were analyzed with an X-ray viewer at 3× magnification. The Chi-square test was used, with the level of significance set at 5%. A total of 64.5% individuals presented with furcation involvement, 43.1% of whom had degree II furcation. A significant association (P = 0.0060) was found between tooth type and frequency of furcation involvement. The first lower and upper molars were affected in 64.5 and 58.5% of cases, respectively. Adequate agreement (0.65) was observed between the clinical and radiographic findings. Taking into consideration the method employed and the results obtained, it may be concluded that the clinical and radiographic examinations performed are effective tools for diagnosing furcation involvement in teeth affected with periodontal disease.

  13. Translationally invariant multipartite Bell inequalities involving only two-body correlators

    International Nuclear Information System (INIS)

    Tura, J; B Sainz, A; Acín, A; Lewenstein, M; Augusiak, R; Vértesi, T

    2014-01-01

    Bell inequalities are natural tools that allow one to certify the presence of nonlocality in quantum systems. The known constructions of multipartite Bell inequalities contain, however, correlation functions involving all observers, making their experimental implementation difficult. The main purpose of this work is to explore the possibility of witnessing nonlocality in multipartite quantum states from the easiest-to-measure quantities, that is, the two-body correlations. In particular, we determine all three- and four-partite Bell inequalities constructed from one- and two-body expectation values that obey translational symmetry, and show that they reveal nonlocality in multipartite states. Also, by providing a particular example of a five-partite Bell inequality, we show that nonlocality can be detected from two-body correlators involving only nearest neighbours. Finally, we demonstrate that any translationally invariant Bell inequality can be maximally violated by a translationally invariant state and the same set of observables at all sites. We provide a numerical algorithm allowing one to seek for maximal violation of a translationally invariant Bell inequality. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘50 years of Bell’s theorem’. (paper)

  14. Specific oxidative stress parameters differently correlate with nailfold capillaroscopy changes and organ involvement in systemic sclerosis.

    Science.gov (United States)

    Riccieri, Valeria; Spadaro, Antonio; Fuksa, Leos; Firuzi, Omidreza; Saso, Luciano; Valesini, Guido

    2008-02-01

    Oxidative stress is suggested to be involved in the pathogenesis of systemic sclerosis (SSc). The aim of the present study was to clarify such a hypothesis by determination of four different plasmatic parameters of oxidative stress, and to define its role in the microvascular damage, assessed by nailfold capillaroscopy (NC). Plasma samples of 18 patients with SSc were analyzed. The biomarkers measured were: total antioxidant capacity, hydroperoxides (ROOHs), and sulfhydryl (SH) and carbonyl (CO) groups. Each patient had a detailed clinical assessment and underwent an NC. The results showed significantly increased ROOHs in SSc patients compared to control group (5.02 +/- 0.24 vs 3.28 +/- 0.19 micromol/l; p capillaroscopy semiquantitative rating scale score (p < 0.05) and with the rating system for avascular areas (p < 0.03). The levels of CO groups inversely correlated with modified Rodnan's skin score (p < 0.039) and were lower in patients with pulmonary fibrosis (p < 0.045), while the levels of SH groups were lower in those presenting gastrointestinal involvement (p < 0.029). The obtained data indicate augmented free radical-mediated injury in SSc and also show correlations among oxidative abnormalities, some clinical findings, and signs of a more severe microvascular involvement. These results give more evidence to the connection between oxidative impairment and SSc.

  15. Learning from games: Stakeholders’ experiences involved in local health policy

    DEFF Research Database (Denmark)

    Spitters, Hilde; van de Goor, Ien; Juel Lau, Cathrine

    2018-01-01

    Since public health problems are complex and the related policies need to address a wide range of sectors, cross-sectoral collaboration is beneficial. One intervention focusing on stimulating collaboration is a ‘policy game’. The focus on specific problems facilitates relationships between...... the stakeholders and stimulates cross-sectoral policymaking. The present study explores stakeholders’ learning experiences with respect to the collaboration process in public health policymaking. This was achieved via their game participation, carried out in real-life stakeholder networks in the Netherlands...... the collaboration processes in local policymaking. Specific learning experiences were related to: (i) the stakeholder network, (ii) interaction and (iii) relationships. The game also increased participant’s understanding of group dynamics and need for a coordinator in policymaking. This exploratory study shows...

  16. Viral fitness does not correlate with three genotype displacement events involving infectious hematopoietic necrosis virus

    Science.gov (United States)

    Kell, Alison M.; Wargo, Andrew R.; Kurath, Gael

    2014-01-01

    Viral genotype displacement events are characterized by the replacement of a previously dominant virus genotype by a novel genotype of the same virus species in a given geographic region. We examine here the fitness of three pairs of infectious hematopoietic necrosis virus (IHNV) genotypes involved in three major genotype displacement events in Washington state over the last 30 years to determine whether increased virus fitness correlates with displacement. Fitness was assessed using in vivo assays to measure viral replication in single infection, simultaneous co-infection, and sequential superinfection in the natural host, steelhead trout. In addition, virion stability of each genotype was measured in freshwater and seawater environments at various temperatures. By these methods, we found no correlation between increased viral fitness and displacement in the field. These results suggest that other pressures likely exist in the field with important consequences for IHNV evolution.

  17. Developing a registry of workers involved in nanotechnology: BASF experiences.

    Science.gov (United States)

    David, Raymond M; Nasterlack, Michael; Engel, Stefan; Conner, Patrick R

    2011-06-01

    To assist BASF in the establishment of a registry of workers involved in nanotechnology. The initial step was a complete inventory of nanomaterials and sites of use. Guidance was developed to clarify which particulate nanomaterials were to be included in the survey. Site management was then contacted by the medical department to obtain a list of workers. The time line for collecting data ranged from several months to a year, depending on the information needed, and presented challenges based on the lack of global definition and labeling of nanomaterials. Less than 50 nanomaterials are used as raw materials in less than 10% of the sites globally. In North America, less than 5% of sites and 5% workers use nanomaterials. Further work is required to integrate the inventory, registry, and exposure assessments.

  18. The Bose-Einstein correlations in CDFII experiment

    Energy Technology Data Exchange (ETDEWEB)

    Lovás, Lubomír [Comenius Univ., Bratislava (Slovakia)

    2008-01-01

    We present the results of a study of p$\\bar{p}$ collisions at √s = 1.96 TeV collected by the CDF-II experiment at Tevatron collider. The Bose-Einstein correlations of the π±π± two boson system have been studied in the minimum-bias high-multiplicity events. The research was carried out on the sample at the size of 173761 events. The two pion correlations have been retrieved. The final results were corrected to the coulomb interactions. Two different reference samples were compared and discussed. A significant two-pion correlation enhancement near origin is observed. This enhancement effect has been used to evaluate the radius of the two-pion emitter source. We have used the TOF detector to distinguish between π and K mesons. The C2(Q) function parameters have also been retrieved for the sample containing only tagged π mesons. A comparison between four different parametrizations based on two diff t theoretical approaches of the C2(Q) function is given.

  19. openBEB: open biological experiment browser for correlative measurements.

    Science.gov (United States)

    Ramakrishnan, Chandrasekhar; Bieri, Andrej; Sauter, Nora; Roizard, Sophie; Ringler, Philippe; Müller, Shirley A; Goldie, Kenneth N; Enimanev, Kaloyan; Stahlberg, Henning; Rinn, Bernd; Braun, Thomas

    2014-03-26

    New experimental methods must be developed to study interaction networks in systems biology. To reduce biological noise, individual subjects, such as single cells, should be analyzed using high throughput approaches. The measurement of several correlative physical properties would further improve data consistency. Accordingly, a considerable quantity of data must be acquired, correlated, catalogued and stored in a database for subsequent analysis. We have developed openBEB (open Biological Experiment Browser), a software framework for data acquisition, coordination, annotation and synchronization with database solutions such as openBIS. OpenBEB consists of two main parts: A core program and a plug-in manager. Whereas the data-type independent core of openBEB maintains a local container of raw-data and metadata and provides annotation and data management tools, all data-specific tasks are performed by plug-ins. The open architecture of openBEB enables the fast integration of plug-ins, e.g., for data acquisition or visualization. A macro-interpreter allows the automation and coordination of the different modules. An update and deployment mechanism keeps the core program, the plug-ins and the metadata definition files in sync with a central repository. The versatility, the simple deployment and update mechanism, and the scalability in terms of module integration offered by openBEB make this software interesting for a large scientific community. OpenBEB targets three types of researcher, ideally working closely together: (i) Engineers and scientists developing new methods and instruments, e.g., for systems-biology, (ii) scientists performing biological experiments, (iii) theoreticians and mathematicians analyzing data. The design of openBEB enables the rapid development of plug-ins, which will inherently benefit from the "house keeping" abilities of the core program. We report the use of openBEB to combine live cell microscopy, microfluidic control and visual

  20. Public involvement in cleanup - the Rocky Flats experience

    International Nuclear Information System (INIS)

    Paukert, J.; Pennock, S.; Schassburger, R.

    1992-01-01

    The U.S. Department of Energy's Rocky Flats Plant recently completed and implemented the Rocky Flats Plant Community Relations Plan for public involvement in environmental restoration of the site. The plan was developed in cooperation with the plant's regulators, the U.S. Environmental Protection Agency and the Colorado Department of Health. In addition, citizens near the plant played a significant role in shaping the document through extensive community interviews and public comment. The result of these cooperative efforts is a plan that meets and exceeds the applicable federal and state community relations requirements for a cleanup program. In fact, the U.S. Environmental Protection Agency has used the Rocky Flats Plant Community Relations Plants a model for similar plans at other federal facilities. Plan development, however, is only the starting point for an effective community relations effort. The Rocky Flats Plant and the public will face many challenges together as we implement the plan and build a partnership for addressing environmental cleanup issues. (author)

  1. Some experiences of public meetings/involvement in Sweden

    International Nuclear Information System (INIS)

    Stroemberg, Bo

    2008-01-01

    Bo Stroemberg from SKI presented recent Swedish experiences of public meetings organised in connection with site investigations and the regular review of RD and D programmes. He introduced examples of stakeholder concerns that have been expressed during RD and D programme reviews. Academic institutions have identified needs for additional research. Environmental groups have raised concerns about potential disruptive events and degradation mechanisms. They have called attention to deficiencies related to decision-making processes, and recommended alternative approaches for site and method selection. Municipalities and local authorities have been critical about the insufficient degree of transparency, while other authorities have focused on legal responsibility, transport safety, and security issues, among others. Next, Mr Stroemberg highlighted examples of technical comments concerning long-term safety. Some of these referred to catastrophic impacts of earthquakes, especially the formation of new fractures, which could invalidate the KBS-3 concept. Others called attention to scenarios of deliberate human intrusion, if for example the repository was excavated as an archaeological site. Some comments concerned the issue of retrievability, the greatest advantage of the KBS-3 method, but also its most important shortcoming, since it would necessitate monitoring and surveillance indefinitely. Some suggested that an inland site with regional recharge conditions should be used, while others proposed the use of deep boreholes, i.e., the location of the repository in deep stagnant conditions. Mr Stroemberg concluded that questions and comments put during public meetings represent useful information to the experts for the identification of issues to be addressed by RD and D

  2. Developments for the 6He beta - nu angular correlation experiment

    Science.gov (United States)

    Zumwalt, David W.

    This thesis describes developments toward the measurement of the angular correlation between the beta and the antineutrino in the beta decay of 6He. This decay is a pure Gamow-Teller decay which is described in the Standard Model as a purely axial vector weak interaction. The angular correlation is characterized by the parameter abetanu = -1/3 in the Standard Model. Any deviation from this value would be evidence for tensor components in the weak interaction and would constitute new physics. A new method will be used to measure the parameter a betanu from 6He decays, featuring a magneto-optical trap that will measure the beta particle in coincidence with the recoiling 6Li daughter ion. This neutral atom trapping scheme provides cold, tightly confined atoms which will reduce systematic uncertainties related to the initial position of the decay. By knowing the initial position of the decay and measuring the time of flight of the recoiling 6Li daughter ion in coincidence with the beta, the angular correlation between the beta and the antineutrino can be deduced. We aim to measure a betanu first to the level of 1%, and eventually to the 0.1% level, which would represent an order of magnitude improvement in precision over past experiments. Towards this goal, we have designed, built, and successfully tested a liquid lithium target to provide >2×10. {10} 6He atoms/sto a low-background environment, which is the most intense source of 6He presently available. This allowed for an additional measurement of the 6He half-life (806.89 +/- 0.11stat +0.23-0.19syst ms) to be made with unprecedented precision, resolving discrepancies in past measurements. We have also tested our trapping and detection apparatus and have begun to record preliminary coincidence events.

  3. Canonical correlation analysis of factors involved in the occurrence of peptic ulcers.

    Science.gov (United States)

    Bayyurt, Nizamettin; Abasiyanik, M Fatih; Sander, Ersan; Salih, Barik A

    2007-01-01

    The impact of risk factors on the development of peptic ulcers has been shown to vary among different populations. We sought to establish a correlation between these factors and their involvement in the occurrence of peptic ulcers for which a canonical correlation analysis was applied. We included 7,014 patient records (48.6% women, 18.4% duodenal ulcer [DU], 4.6% gastric ulcer [GU]) of those underwent upper gastroendoscopy for the last 5 years. The variables measured are endoscopic findings (DU, GU, antral gastritis, erosive gastritis, pangastritis, pyloric deformity, bulbar deformity, bleeding, atrophy, Barret esophagus and gastric polyp) and risk factors (age, gender, Helicobacter pylori infection, smoking, alcohol, and nonsteroidal anti-inflammatory drugs [NSAIDs] and aspirin intake). We found that DU had significant positive correlation with bulbar deformity (P=2.6 x 10(-23)), pyloric deformity (P=2.6 x 10(-23)), gender (P=2.6 x 10(-23)), H. pylori (P=1.4 x 10(-15)), bleeding (P=6.9 x 10(-15)), smoking (P=1.4 x 10(-7)), aspirin use (P=1.1 x 10(-4)), alcohol intake (P=7.7 x 10(-4)), and NSAIDs (P=.01). GU had a significantly positive correlation with pyloric deformity (P=1,6 x 10(-15)), age (P=2.6 x 10(-14)), bleeding (P=3.7 x 10(-8)), gender (P=1.3 x 10(-7)), aspirin use (P=1.1 x 10(-6)), bulbar deformity (P=7.4 x 10(-4)), alcohol intake (P=.03), smoking (P=.04), and Barret esophagus (P=.03). The level of significance was much higher in some variables with DU than with GU and the correlations with GU in spite of being highly significant the majority, were small in magnitude. In conclusion, Turkish patients with the following endoscopic findings bulbar deformity and pyloric deformity are high-risk patients for peptic ulcers with the risk of the occurrence of DU being higher than that of GU. Factors such as H. pylori, smoking, alcohol use, and NSAIDs use (listed in a decreasing manner) are risk factors that have significant impact on the occurrence of DU

  4. Comment on ''a classical model of EPR experiment with quantum mechanical correlations and Bell inequalities''

    International Nuclear Information System (INIS)

    Aspect, A.

    1986-01-01

    The author states that ''It is impossible to mimick the quantum mechanical predictions for the EPR correlations, with a reasonable classical-looking model, in the spirit of Einstein's ideas''. The author feels that if he is wrong somebody could make a classical model (i.e. following the laws of classical physics) mimicking all the quantum mechanical predictions for the EPR correlations. He attempts to show that it is not the case for Barut's model for the following reasons: the first version of his model is classical, but doesn't mimick at all an EPR type experiment; and by reinterpretation one can get a model that does mimick the experiment, but this model is no longer ''reasonably classical looking'' since it involves negative probabilities. The claim is put in the form of a challenge. It is shown that the model under discussion can be reinterpreted by adding a chip converting the continuous outputs into two-valved outputs

  5. An exploration of the perceptions of male partners involved in the birthing experience at a regional Australian hospital.

    Science.gov (United States)

    Porrett, Liesel; Barkla, Sally; Knights, Janice; de Costa, Caroline; Harmen, Sonia

    2013-01-01

    The benefits to women of having their male partners present during labor and birth have been well documented, but the effects on men of sharing the birth experience have been less well explored. Several studies have suggested that male partners' positive experiences at this time may benefit partner and family relationships subsequently, whereas negative experiences may translate into later difficulties in these relationships. This study explored the perceptions of male partners involved in the birthing experience in the Integrated Women's Health Unit of Cairns Base Hospital, Cairns, Australia, over a 6-month period in 2010. The aims of the study were to document male partners' self-reported perceptions of their antenatal, labor, and birth experiences and birth expectations and birth involvement and to determine whether these perceptions influenced their feelings that their presence during birth was beneficial to the birthing woman. Participants were men experiencing for the first time their partner giving birth. A self-administered 14-item questionnaire was used to collect data; 163 of 200 eligible participants returned completed questionnaires. Continuous variables were converted to categorical variables and chi-square testing was used to determine significant differences between groups. The relationship between beneficial presence and antenatal, labor, and birthing experiences was assessed using correlation analysis and hierarchical regression analysis. There was a significant relationship demonstrated between perceived benefit of the partners' presence and positive perception of both antenatal experience and birth involvement. There also was a positive relationship between realized birth expectations and both antenatal experience and birth involvement. This study suggests that male partners' perceptions of beneficial presence during the birth experience can be enhanced by their feeling well informed and supported during the antenatal period and feeling involved

  6. Correlates of self-harm and suicide attempts in justice-involved young people

    Science.gov (United States)

    Spivak, Benjamin; Borschmann, Rohan; Kinner, Stuart A.; Hachtel, Henning

    2018-01-01

    The purpose of this study was to ascertain the prevalence and correlates of self-harm among young people in detention in Australia. The sample included 215 (177 male; 38 female) young people who were in youth detention in the state of Victoria, Australia. Participants were administered a series of questionnaires related to self-harm, mental health, socio-environmental experiences and behaviours. Overall, one-third (33%) of the sample reported previous self-harm and 12% reported at least one suicide attempt. In a multivariate logistic regression analysis, a history of childhood trauma, contact with mental health services, and low educational interest significantly increased the likelihood of self-harm. Young people who reported a suicide attempt scored significantly higher on the measure of childhood trauma than did youth who had engaged in non-suicidal self-harm. Findings demonstrate a strong connection between childhood traumatic experiences and suicidal behaviours for youth in detention. Trauma histories and mental health concerns must be considered when identifying youth at increased risk of self-harm. PMID:29447289

  7. Correlation experiments and the nonvalidity of ordinary ideas about the physical world

    International Nuclear Information System (INIS)

    Stapp, H.P.

    1976-01-01

    It is shown that the predictions of quantum theory in certain correlations experiments are incompatible with ordinary ideas about the physical world. In particular the following theorem is proved: Consider situations involving two experimenters, one working in each of two space-like separated regions. Suppose each is apparently free to choose to perform in his region one of two alternative experiments. Assume that the results that would be obtained in each of the alternative cases conform to the statistical predictions of quantum theory. Then the experimental results in one region must, in some cases, depend on which experiment is performed in the space-like separated region. This theorem is akin to a theorem of J. S. Bell. However, Bell's theorem refers to hidden-variables, which may not exist in nature, whereas the present theorem deals directly with connections between the (macroscopic) results of possible measurements and physical variables subject to the control of experimenters

  8. Patient Involvement in Geriatric Care – Results and Experiences from a Mixed Models Design Study within Project INTEGRATE

    Directory of Open Access Journals (Sweden)

    Joern Kiselev

    2018-02-01

    Full Text Available Introduction: Patient involvement is a core component of an integrated care approach. While the benefits and prerequisites of patient involvement have been described in general and additionally for some target populations, little is known about the views and experiences of older people regarding this matter. Methods: A study with a mixed-methods design was conducted to gain a better understanding about patient involvement in geriatric care. A questionnaire on shared decision-making was administered within a group of older adults in Germany. Additionally, 7 focus groups with health professionals and geriatric patients in Germany and Estonia were held to deepen the insight of the questionnaire and discussing experiences and barriers of patient involvement. Results: Older people without an actual medical problem expressed a significantly higher desire to participate in shared decisions than those requiring actual medical care. No significant differences could be found for the desire to be informed as part of the care process. No correlation between patients’ desire and experiences on shared decision-making could be observed. In the focus groups, patients demanded a comprehensive and understandable information and education process while the health professionals’ view was very task-specific. This conflict led to a loss of trust by the patients. Conclusions: There is a gap between patients’ and health professionals’ views on patient involvement in older people. The involvement process should therefore be comprehensive and should take into account different levels of health literacy.

  9. Correlates of Sex Trading among Drug-Involved Women in Committed Intimate Relationships: A Risk Profile.

    Science.gov (United States)

    Jiwatram-Negrón, Tina; El-Bassel, Nabila

    2015-01-01

    Despite a slight decline in new human immunodeficiency virus (HIV) infections in New York, marked increases and concentrated epidemics continue among subsets of the population, including women engaged in sex trading. We examined the prevalence and correlates of sex trading among 346 low-income, HIV-negative women in HIV-concordant intimate relationships. Women and their long-term main partners were recruited to participate in an HIV prevention intervention. Baseline data were used in this article. Of the 346 women in the study, 28% reported sex trading during the prior 90 days. Multivariate analyses showed increased relative risk of sex trading by lifetime experience of severe intimate partner violence (IPV), drug, and alcohol use, and marginal significance for mental health hospitalization, partner drug dependency, and homelessness. These findings suggest an urgent need for HIV prevention and intervention efforts targeted toward women in intimate relationships who trade sex for money or drugs, with an emphasis on IPV, mental health, history of incarceration, and substance abuse. Copyright © 2015 Jacobs Institute of Women's Health. Published by Elsevier Inc. All rights reserved.

  10. Embedding a Recovery Orientation into Neuroscience Research: Involving People with a Lived Experience in Research Activity.

    Science.gov (United States)

    Stratford, Anthony; Brophy, Lisa; Castle, David; Harvey, Carol; Robertson, Joanne; Corlett, Philip; Davidson, Larry; Everall, Ian

    2016-03-01

    This paper highlights the importance and value of involving people with a lived experience of mental ill health and recovery in neuroscience research activity. In this era of recovery oriented service delivery, involving people with the lived experience of mental illness in neuroscience research extends beyond their participation as "subjects". The recovery paradigm reconceptualises people with the lived experience of mental ill health as experts by experience. To support this contribution, local policies and procedures, recovery-oriented training for neuroscience researchers, and dialogue about the practical applications of neuroscience research, are required.

  11. The Impact of Parental Involvement on a Structured Youth Program Experience: A Qualitative Inquiry

    Directory of Open Access Journals (Sweden)

    Mat D. Duerden

    2013-12-01

    Full Text Available Parental involvement is an often proposed, but rarely researched, key element of youth programs. Questions remain regarding the impact of parental involvement on program processes and outcomes. Qualitative data were collected over a one-year period with youth participants (n=46, parents (n=26, and teachers (n=5 associated with an international immersion/service learning program for adolescents. Three main research questions guided the data analysis: (1 what role does parental involvement play in the youths’ experience in the program; (2 how does parental involvement in the program influence the parent/child relationship; and (3 what role does parental involvement play in terms of the program’s long-term impact on the youth participants? Findings suggest a relationship between parental involvement in youth programs and improved parent/child communication, bonding, and perceptions of one another. Findings also suggest that having a common ground experience prolonged the experience’s positive post-participation effects.

  12. Correlates of Bulimia Nervosa: Early Family Mealtime Experiences.

    Science.gov (United States)

    Miller, Debra A. F.; And Others

    1993-01-01

    Examined relationship of early mealtime experiences to later bulimia in 128 female college students. Found significant group differences among bulimics, nonbulimics, and repeat dieters on early meal experience questionnaire, with bulimic group reporting most negative and unusual experiences. Found significant differences among groups on depression…

  13. Mathematical Experiences and Parental Involvement of Parents Who Are and Who Are Not Mathematicians

    Science.gov (United States)

    Antolin Drešar, Darja; Lipovec, Alenka

    2017-01-01

    Previous studies suggest that parental involvement in children's mathematics education is more established for parents who feel competent in mathematics. This qualitative study aimed to gain an in-depth insight into the experiences of parental involvement of two different groups of parents: those who are mathematicians and those who are not. Data…

  14. openBEB: open biological experiment browser for correlative measurements

    OpenAIRE

    Ramakrishnan, Chandrasekhar; Bieri, Andrej; Sauter, Nora; Roizard, Sophie; Ringler, Philippe; Müller, Shirley A; Goldie, Kenneth N; Enimanev, Kaloyan; Stahlberg, Henning; Rinn, Bernd; Braun, Thomas

    2014-01-01

    Background: New experimental methods must be developed to study interaction networks in systems biology. To reduce biological noise, individual subjects, such as single cells, should be analyzed using high throughput approaches. The measurement of several correlative physical properties would further improve data consistency. Accordingly, a considerable quantity of data must be acquired, correlated, catalogued and stored in a database for subsequent analysis. Results: We have developed openBE...

  15. The Northern Experience of Street-Involved Youth: A Narrative Inquiry

    Science.gov (United States)

    George, Serena D.; O'Neill, Linda K.

    2011-01-01

    This research explored the experiences of 8 street-involved youth (4 male, 4 female) between the ages of 20 and 27 living in north-central British Columbia. The analysis was carried out in 3 phases based on the narrative approach developed by Lieblich, Tuval-Mashiach, and Zilber (1998). The narratives represented the holistic experiences of the…

  16. CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease.

    Science.gov (United States)

    Cohen, Oren S; Chapman, Joab; Korczyn, Amos D; Siaw, Oliver L; Warman-Alaluf, Naama; Nitsan, Zeev; Appel, Shmuel; Kahana, Esther; Rosenmann, Hanna; Hoffmann, Chen

    2016-11-10

    Cerebrospinal fluid (CSF) tau was found to correlate with disease severity and cognitive status in E200K familial Creutzfeldt-Jakob disease (fCJD) patients. The objective of the present study was to test whether tau levels in the CSF also correlate with the disease burden as reflected by the degree of cortical involvement in DWI MRI. Forty-four consecutive E200K fCJD patients (25 males, mean age 58.6±7.5, range 48-75 years) were recruited to the study and had a CSF tau examination as well as measurements of the extent of the cortical involvement in the DWI axial MRI. Correlation was tested using Pearson test. A significant correlation (r=0.617 pdisease burden reinforce the notion that tau can be used as a biomarker reflecting the extent of disease in patients with E200K fCJD. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  17. Community Involvement of Young Adults with Intellectual Disabilities: Their Experiences and Perspectives on Inclusion.

    Science.gov (United States)

    Hall, Sarah A

    2017-09-01

    Inclusion in the community is essential to enhancing a person's quality of life. Although people with intellectual disabilities have a desire to be more involved in activities, they experience barriers that limit their inclusion. The purpose of this study was to describe the community involvement of young adults with intellectual disability. I interviewed fourteen young adults with intellectual disability to explore their involvement in work, recreation and leisure activities. Four themes emerged from the data: vocational endeavours, leisure pursuits, social inclusion and supports. The contexts of their experiences either facilitated or hindered their community involvement. The community involvement of young adults with intellectual disability varies depending on the opportunities and supports available to them. Their inclusion in the community may be enhanced by additional transportation options, continuing education in vocational and social skills, personalized guidance from group members and environments that are welcoming to people with disabilities. © 2016 John Wiley & Sons Ltd.

  18. Retrospective North American CFL Experience Curve Analysis and Correlation to Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Sarah J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wei, Max [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sohn, Michael D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-07-01

    Retrospective experience curves are a useful tool for understanding historic technology development, and can contribute to investment program analysis and future cost estimation efforts. This work documents our development of an analysis approach for deriving retrospective experience curves with a variable learning rate, and its application to develop an experience curve for compact fluorescent lamps for the global and North American markets over the years 1990-2007. Uncertainties and assumptions involved in interpreting data for our experience curve development are discussed, including the processing and transformation of empirical data, the selection of system boundaries, and the identification of historical changes in the learning rate over the course of 15 years. In the results that follow, we find that that the learning rate has changed at least once from 1990-2007. We also explore if, and to what degree, public deployment programs may have contributed to an increased technology learning rate in North America. We observe correlations between the changes in the learning rate and the initiation of new policies, abrupt technological advances, including improvements to ballast technology, and economic and political events such as trade tariffs and electricity prices. Finally, we discuss how the findings of this work (1) support the use of segmented experience curves for retrospective and prospective analysis and (2) may imply that investments in technological research and development have contributed to a change in market adoption and penetration.

  19. Correlating Parental Involvement and Mathematics Achievement of African American Eighth-Grade Students

    Science.gov (United States)

    Oyerinde, Bolanle Adenike

    2014-01-01

    Low involvement of African American parents in middle school education is a concern in a school district in the southeastern United States. The purpose of this quantitative study was to investigate the relationships between the explanatory variables of parental involvement, socioeconomic status, and level of education, and the achievement of…

  20. Agricultural experiences as correlates of secondary school students ...

    African Journals Online (AJOL)

    African Research Review ... Instruments used were Career Decision Questionnaire, Agricultural Experience Questionnaire and ... in agriculture while poultry (β = -0.333) mostly predicted students career decision in Agricultural Science.

  1. Bell inequalities and experiments on quantum correlations for macroscopic distances

    International Nuclear Information System (INIS)

    Grib, A.A.

    1984-01-01

    Recently in different laboratories experiments checking the validity of Bell's inequalities were made. These inequalities give the answer to the qUestion which interpretation of quantum mechanics is correct: either Einstein's interpretation according to which properties of quantum system exist as elements of physical reality independently from their observation or Copenhagen's interpretation due to Bohr and Fock according to which quantUm properties described by noncommuting operators don't exist independently from measurement. Experiments are classified on three groups: Those with optical photons with γ-quanta and with nucleons. The experiments undoubtedly show that Bell's inequalities are not satisfied, so the Copenhagen's interpretation of quantum mehanics and the principle of relativity to the means of measurement of properties of the microsystem give the only non-contradicting-to-experiment description of quantum phenomena

  2. Neural correlates of the LSD experience revealed by multimodal neuroimaging.

    Science.gov (United States)

    Carhart-Harris, Robin L; Muthukumaraswamy, Suresh; Roseman, Leor; Kaelen, Mendel; Droog, Wouter; Murphy, Kevin; Tagliazucchi, Enzo; Schenberg, Eduardo E; Nest, Timothy; Orban, Csaba; Leech, Robert; Williams, Luke T; Williams, Tim M; Bolstridge, Mark; Sessa, Ben; McGonigle, John; Sereno, Martin I; Nichols, David; Hellyer, Peter J; Hobden, Peter; Evans, John; Singh, Krish D; Wise, Richard G; Curran, H Valerie; Feilding, Amanda; Nutt, David J

    2016-04-26

    Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the human brain have never been studied before with modern neuroimaging. Here, three complementary neuroimaging techniques: arterial spin labeling (ASL), blood oxygen level-dependent (BOLD) measures, and magnetoencephalography (MEG), implemented during resting state conditions, revealed marked changes in brain activity after LSD that correlated strongly with its characteristic psychological effects. Increased visual cortex cerebral blood flow (CBF), decreased visual cortex alpha power, and a greatly expanded primary visual cortex (V1) functional connectivity profile correlated strongly with ratings of visual hallucinations, implying that intrinsic brain activity exerts greater influence on visual processing in the psychedelic state, thereby defining its hallucinatory quality. LSD's marked effects on the visual cortex did not significantly correlate with the drug's other characteristic effects on consciousness, however. Rather, decreased connectivity between the parahippocampus and retrosplenial cortex (RSC) correlated strongly with ratings of "ego-dissolution" and "altered meaning," implying the importance of this particular circuit for the maintenance of "self" or "ego" and its processing of "meaning." Strong relationships were also found between the different imaging metrics, enabling firmer inferences to be made about their functional significance. This uniquely comprehensive examination of the LSD state represents an important advance in scientific research with psychedelic drugs at a time of growing interest in their scientific and therapeutic value. The present results contribute important new insights into the characteristic hallucinatory and consciousness-altering properties of psychedelics that inform on how they can model certain pathological states and potentially treat others.

  3. Correlation between clinical and radiographic findings on the occurrence of furcation involvement in patients with periodontitis

    Directory of Open Access Journals (Sweden)

    Estela Santos Gusmão

    2014-01-01

    Conclusion: Taking into consideration the method employed and the results obtained, it may be concluded that the clinical and radiographic examinations performed are effective tools for diagnosing furcation involvement in teeth affected with periodontal disease.

  4. Investigating the use of patient involvement and patient experience in quality improvement in Norway

    DEFF Research Database (Denmark)

    Wiig, Siri; Storm, Marianne; Aase, Karina

    2013-01-01

    -fold: 1) to describe and analyze how governmental organizations expect acute hospitals to incorporate patient involvement and patient experiences into their quality improvement (QI) efforts and 2) to analyze how patient involvement and patient experiences are used by hospitals to try to improve...... the quality of care they provide. METHODS: This multi-level case study combines analysis of national policy documents and regulations at the macro level with semi-structured interviews and non-participant observation of key meetings and shadowing of staff at the meso and micro levels in two purposively...... in hospitals. The expectations span from systematic collection of patients' and family members' experiences for the purpose of improving service quality through establishing patient-oriented arenas for ongoing collaboration with staff to the support of individual involvement in decision making. However...

  5. Modelling the fathering role: Experience in the family of origin and father involvement

    Directory of Open Access Journals (Sweden)

    Mihić Ivana

    2012-01-01

    Full Text Available The study presented in this paper deals with the effects of experiences with father in the family of origin on the fathering role in the family of procreation. The results of the studies so far point to great importance of such experiences in parental role modelling, while recent approaches have suggested the concept of introjected notion or an internal working model of the fathering role as the way to operationalise the transgenerational transfer. The study included 247 two-parent couple families whose oldest child attended preschool education. Fathers provided information on self-assessed involvement via the Inventory of father involvement, while both fathers and mothers gave information on introjected experiences from the family of origin via the inventory Presence of the father in the family of origin. It was shown that father’s experiences from the family of origin had significant direct effects on his involvement in child-care. Very important experiences were those of negative emotional exchange, physical closeness and availability of the father, as well as beliefs about the importance of the father as a parent. Although maternal experiences from the family of origin did not contribute significantly to father involvement, shared beliefs about father’s importance as a parent in the parenting alliance had an effect on greater involvement in child-care. The data provide confirmation of the hypotheses on modelling of the fathering role, but also open the issue of the factor of intergenerational maintenance of traditional forms of father involvement in families in Serbia.

  6. Two-detector cross correlation experiments in the heavy water

    Energy Technology Data Exchange (ETDEWEB)

    Jovanovic, S [Boris Kidric Institute of nuclear sciences Vinca, Belgrade (Yugoslavia)

    1969-12-15

    The objective of the task presented in this paper was to develop the instrumentation for Cross Spectral Density method (CPSD) as well as to perform Autopower Spectral Density (APSD) and CPSD experiments with different efficiencies of ionization chambers to compare them. Two ionization chambers with the same sensitivity were were used at different axial positions of the reactor. The experiment was done at the RB reactor in Vinca at the delayed critical state only. The lattice pitch was 16 cm, and 2% enriched fuel fuel was used.

  7. Experience and meaning of user involvement: some explorations from a community mental health project.

    Science.gov (United States)

    Truman, Carole; Raine, Pamela

    2002-05-01

    With an increased interest in and policy commitment to involving service users in the planning and delivery of health service provision, there is a clear need to explore both the rhetoric and realities of what user involvement entails. In the present paper, by drawing upon an evaluation of a community-based exercise facility for people with mental health problems, the authors explore ways in which the reality of user involvement is subject to a range of configurations within health services. The paper describes a piece of qualitative research that was undertaken within a participatory framework to explore the nature of user involvement within the facility. The data have been analysed using a grounded theory approach to provide insights into: the organisational context in which user involvement takes place; factors which encourage meaningful participation on the part of service users; perceived barriers to user involvement; and issues of sustainability and continuity. This research approach has enabled the authors to explore the views and experiences of users, service providers and referral agencies in relation to the nature and potential for user involvement. The findings illustrate ways in which user involvement may take place under both flexible and formal arrangements across a variety of activities. The present paper provides an account of some of the meanings and experiences of what 'successful' user participation may involve and the conditions which underpin 'success'. The authors conclude that successful and meaningful user involvement should enable and support users to recognise their existing skills, and to develop new ones, at a pace that suits their particular circumstances and personal resources. This process may require adaptation not only by organisations, but also by service providers and non-involved users.

  8. Correlating 3D Experiments with Dynamic Figures Analysis

    Directory of Open Access Journals (Sweden)

    Liliana Saidon

    2010-05-01

    Full Text Available Integrating geometry, algebra and calculus in computer-mediated activities by means of a free software such as GeoGebra is a challenge for all participants involved, and requires a reciprocal conceptual exploratory alternative for the teaching and learning of mathematics at pre-universitary level. This approach allows for the development of meta-mathematical competences in technical fields at introductory levels in sciences and enhances “projecting competences”.

  9. Measuring decision weights in recognition experiments with multiple response alternatives: comparing the correlation and multinomial-logistic-regression methods.

    Science.gov (United States)

    Dai, Huanping; Micheyl, Christophe

    2012-11-01

    Psychophysical "reverse-correlation" methods allow researchers to gain insight into the perceptual representations and decision weighting strategies of individual subjects in perceptual tasks. Although these methods have gained momentum, until recently their development was limited to experiments involving only two response categories. Recently, two approaches for estimating decision weights in m-alternative experiments have been put forward. One approach extends the two-category correlation method to m > 2 alternatives; the second uses multinomial logistic regression (MLR). In this article, the relative merits of the two methods are discussed, and the issues of convergence and statistical efficiency of the methods are evaluated quantitatively using Monte Carlo simulations. The results indicate that, for a range of values of the number of trials, the estimated weighting patterns are closer to their asymptotic values for the correlation method than for the MLR method. Moreover, for the MLR method, weight estimates for different stimulus components can exhibit strong correlations, making the analysis and interpretation of measured weighting patterns less straightforward than for the correlation method. These and other advantages of the correlation method, which include computational simplicity and a close relationship to other well-established psychophysical reverse-correlation methods, make it an attractive tool to uncover decision strategies in m-alternative experiments.

  10. Older peoples experiences involving the decision to transition to an aged care home

    OpenAIRE

    Zamanzadeh Vahid; Pakpour Vahid; Rahmani Azad; Lorraine Chenoweth Lynnette; Mohammadi Eesa

    2016-01-01

    The decision to relocate to an aged care home can is important change in older adults live but little attention has been paid to their experiences of this decision. The study explored older people’s experiences involving the decision to transition to an aged care home. Data were obtained via semi-structured interviews with 17 participants, which were content analyzed. Results: Transition motives, ambiguity, participation in decision making and decision making meaning were four the...

  11. Granular filtration for airborne particles : correlation between experiments and models

    Energy Technology Data Exchange (ETDEWEB)

    Golshahi, L.; Tan, Z. [Calgary Univ., AB (Canada). Schulich School of Engineering, Mechanical and Manufacturing Dept.; Abedi, J. [Calgary Univ., AB (Canada). Schulich School of Engineering, Chemical and Petroleum Engineering Dept.

    2009-10-15

    A new design for a packed bed granular filter was presented. The cylindrical packed bed was designed to filter particles in the range of approximately 10 nm to 15 {mu}m in diameter in different kinetic conditions and configurations. The aim of the study was to develop a precise empirical model to predict the filtration efficiency of the packed beds. A collision-type atomizer was used to generate polydisperse sodium chloride aerosol particles. The effect of flow rates was studied using a thermal mass flow meter. A regression analysis technique was used to determine the correlation between single granule and total packed bed efficiency for the entire granular filter. The experimental data were then compared with results obtained from the theoretical analysis. The least square method was used to correlate experimental data and to develop generalized equations for single granule efficiency. The study showed that the granular filter media has a high filtration efficiency for both micron and submicron particles. It was concluded that the effect of media thickness was more significant at higher flow rates than at lower flow rates. 10 refs., 3 figs.

  12. On Storks and Babies: Correlation, Causality and Field Experiments

    Directory of Open Access Journals (Sweden)

    Lambrecht Anja

    2016-11-01

    Full Text Available The explosion of available data has created much excitement among marketing practitioners about their ability to better understand the impact of marketing investments. Big data allows for detecting patterns and often it seems plausible to interpret them as causal. While it is quite obvious that storks do not bring babies, marketing relationships are usually less clear. Apparent “causalities” often fail to hold up under examination. If marketers want to be sure not to walk into a causality trap, they need to conduct field experiments to detect true causal relationships. In the present digital environment, experiments are easier than ever to execute. However, they need to be prepared and interpreted with great care in order to deliver meaningful and genuinely causal results that help improve marketing decisions.

  13. A Correlational Study of Extracurricular Involvement and Homework Performance of Third Grade Students

    Science.gov (United States)

    Johnson, Rachel; Moulden, Ryan

    2011-01-01

    There are many opportunities for students to participate in nonacademic activities. These activities can include: sports, clubs, private lessons, and religious activities. Participation in these activities enriches students' lives by encouraging social skills. Yet, if students are involved in activities requiring many hours of participation, does…

  14. Psycho-social correlates of students' involvement in secret cults and ...

    African Journals Online (AJOL)

    The study focuses on the premise of incessant havoc being perpetrated by adherents of secret cults in the country's institution of higher learning. These cult groups terrorize fellow students, intimidate members of campus communities in various ways and are often involved in crimes like rape, burglary, thuggery, stealing, ...

  15. Studies of electron correlation effects in multicharged ion atom collisions involving double capture

    Energy Technology Data Exchange (ETDEWEB)

    Stolterfoht, N.; Sommer, K.; Griffin, D.C.; Havener, C.C.; Huq, M.S.; Phaneuf, R.A.; Swenson, J.K.; Meyer, F.W.

    1988-01-01

    We review measurements of L-Coster Kronig and Auger electron production in slow, multicharged collision systems to study electron correlation effects in the process of double electron capture. The n/sup /minus/3/ law was confirmed for the production of the Coster-Kronig configurations 1s/sup 2/2pn/ell/ (n greater than or equal to 6) in O/sup 6 +/ + He collisions. Enhancement of high angular momentum /ell/ in specific 1s/sup 2/2pn/ell/ configurations was observed by means of high-resolution measurements of the Coster-Kronig lines. The importance of electron correlation effects in couplings of potential energy curves leading to the 1s/sup 2/2pn/ell/ configurations is verified by means of Landau-Zener model calculations. 32 refs., 4 figs.

  16. Studies of electron correlation effects in multicharged ion atom collisions involving double capture

    International Nuclear Information System (INIS)

    Stolterfoht, N.; Sommer, K.; Griffin, D.C.; Havener, C.C.; Huq, M.S.; Phaneuf, R.A.; Swenson, J.K.; Meyer, F.W.

    1988-01-01

    We review measurements of L-Coster Kronig and Auger electron production in slow, multicharged collision systems to study electron correlation effects in the process of double electron capture. The n/sup /minus/3/ law was confirmed for the production of the Coster-Kronig configurations 1s 2 2pn/ell/ (n ≥ 6) in O 6+ + He collisions. Enhancement of high angular momentum /ell/ in specific 1s 2 2pn/ell/ configurations was observed by means of high-resolution measurements of the Coster-Kronig lines. The importance of electron correlation effects in couplings of potential energy curves leading to the 1s 2 2pn/ell/ configurations is verified by means of Landau-Zener model calculations. 32 refs., 4 figs

  17. Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease

    DEFF Research Database (Denmark)

    Kovács, Gábor G; Gelpi, Ellen; Ströbel, Thomas

    2007-01-01

    The endosomal-lysosomal system (ELS) has been suggested to play a role in the pathogenesis of prion diseases. The purpose of this study was to examine how experimental observations can be translated to human neuropathology and whether alterations of the ELS relate to neuropathologic changes...... correlate with regional pathology. Overloading of this system might impair the function of lysosomal enzymes and thus may mimic some features of lysosomal storage disorders. Udgivelsesdato: 2007-Jul...

  18. Parents' Experiences as Predictors of State Accountability Measures of Schools' Facilitation of Parent Involvement

    Science.gov (United States)

    Elbaum, Batya; Blatz, Erin T.; Rodriguez, Raymond J.

    2016-01-01

    The aim of this study was to ascertain which dimensions of parents' experiences with schools are most strongly associated with parents' perceptions that schools are or are not facilitating parent involvement as mandated by the federal accountability system under the Individuals With Disabilities Education Act (IDEA). Participants were 92 parents…

  19. An e-Learning System with MR for Experiments Involving Circuit Construction to Control a Robot

    Science.gov (United States)

    Takemura, Atsushi

    2016-01-01

    This paper proposes a novel e-Learning system for technological experiments involving electronic circuit-construction and controlling robot motion that are necessary in the field of technology. The proposed system performs automated recognition of circuit images transmitted from individual learners and automatically supplies the learner with…

  20. Framing the Undergraduate Research Experience: Discovery Involvement in Retailing Undergraduate Education

    Science.gov (United States)

    Sternquist, Brenda; Huddleston, Patricia; Fairhurst, Ann

    2018-01-01

    We provide an overview of ways to involve undergraduate business and retailing students in faculty research projects and discuss advantages of these student-faculty collaborations. We use Kolb's experiential learning cycle to provide a framework for creating an effective and engaging undergraduate research experience and use it to classify types…

  1. Parental Beliefs and Experiences Regarding Involvement in Intervention for Their Child with Speech Sound Disorder

    Science.gov (United States)

    Watts Pappas, Nicole; McAllister, Lindy; McLeod, Sharynne

    2016-01-01

    Parental beliefs and experiences regarding involvement in speech intervention for their child with mild to moderate speech sound disorder (SSD) were explored using multiple, sequential interviews conducted during a course of treatment. Twenty-one interviews were conducted with seven parents of six children with SSD: (1) after their child's initial…

  2. Collegiate Diversity Experiences and Students' Views Regarding Social and Political Involvement

    Science.gov (United States)

    Parker, Eugene T., III; Trolian, Teniell L.

    2015-01-01

    Using data from the Wabash National Study of Liberal Arts Education, this study examines the relationship between engagement in diversity experiences during college and student attitudes about the importance of being socially and politically involved at the end of their fourth year of college. Findings suggest a positive link between…

  3. Involving People with Lived Experience of Homelessness in Electronic Health Records Research

    Directory of Open Access Journals (Sweden)

    Serena Luchenski

    2017-04-01

    Using a participatory and dynamic approach to involve people with lived experience of homelessness and exclusion is an effective public engagement methodology for complex topics such as EHR research and data linkage. Information provided in the workshop was useful for interpreting findings, identifying strengths and gaps in health and social services, and developing research and practice recommendations.

  4. Cutaneous involvement in multiple myeloma (MM): A case series with clinicopathologic correlation.

    Science.gov (United States)

    Malysz, Jozef; Talamo, Giampaolo; Zhu, Junjia; Clarke, Loren E; Bayerl, Michael G; Ali, Liaqat; Helm, Klaus F; Chung, Catherine G

    2016-05-01

    Disease-specific skin lesions are rare in patients with multiple myeloma (MM). We sought to further characterize the clinical and pathologic features of patients with cutaneous involvement with MM. We identified 13 patients with cutaneous lesions of MM. Cutaneous lesions consisted of pink, red, and violaceous papules, nodules, and/or plaques that varied in size. Histopathology revealed atypical plasma cells with occasional plasmablastic features. MM had aggressive biologic features and was at an advanced stage in the majority of patients. Despite aggressive management, including chemotherapy and stem-cell transplantation, most patients died of progressive disease within a few months after the development of cutaneous lesions. The study group was relatively small. Cutaneous involvement with MM is associated with aggressive biologic behavior and short survival. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  5. Electoral Proximity and the Political Involvement of Bureaucrats: A Natural Experiment in Argentina, 1904

    Directory of Open Access Journals (Sweden)

    Valentín Figueroa

    2016-01-01

    Full Text Available In this paper, I use a slightly modified version of the Becker–Stigler model of corrupt behavior to explain bureaucratic political involvement. Since bureaucrats prefer higher rewards and not to support losing candidates, we expect them to become politically involved near elections – when rewards are expected to be higher, and information more abundant. Taking advantage of a natural experiment, I employ differences-in-means and differences-in-differences techniques to esti-mate the effect of electoral proximity on the political involvement of justices of the peace in the city of Buenos Aires in 1904. I find a large, positive, and highly local effect of electoral proximity on their political involvement, with no appreciable impact in the months before or after elections.

  6. The influence of group membership on the neural correlates involved in empathy.

    Directory of Open Access Journals (Sweden)

    Robert eEres

    2013-05-01

    Full Text Available Empathy involves affective, cognitive and emotion regulative components. The affective component relies on the sharing of emotional states with others and is discussed here in relation to the human Mirror System. On the other hand, the cognitive component is related to understanding the mental states of others and draws upon literature surrounding Theory of Mind. The final component, emotion regulation depends on executive function and is responsible for managing the degree to which explicit empathic responses are made. This mini-review provides information on how each of the three components is individually affected by group membership and how this leads to in-group bias.

  7. Slow or swift, your patients' experience won't drift: absence of correlation between physician productivity and the patient experience.

    Science.gov (United States)

    Lenz, Kasia; McRae, Andrew; Wang, Dongmei; Higgins, Benjamin; Innes, Grant; Cook, Timothy; Lang, Eddy

    2017-09-01

    Absract OBJECTIVES: To evaluate the relationship between Emergency Physician (EP) productivity and patient satisfaction with Emergency Department (ED) care. This retrospective observational study linked administrative and patient experience databases to measure correlations between the patient experience and EP productivity. The study was performed across three Calgary EDs (from June 2010 to July 2013). Patients>16 years old with completed Health Quality Council of Alberta (HQCA) ED Patient Experience Surveys were included. EP productivity was measured at the individual physician level and defined as the average number of patients seen per hour. The association between physician productivity and patient experience scores from six composite domains of the HQCA ED Patient Experience Survey were examined using Pearson correlation coefficients, linear regression modelling, and a path analysis. We correlated 3,794 patient experience surveys with productivity data for 130 EPs. Very weak non-significant negative correlations existed between productivity and survey composites: "Staff Care and Communication" (r=-0.057, p=0.521), "Discharge Communication" (r=-0.144, p=0.102), and "Respect" (r=-0.027, p=0.760). Very weak, non-significant positive correlations existed between productivity and the composite domains: "Medication Communication" (r=0.003, p=0.974) and "Pain management" (r=0.020, p=0.824). A univariate general linear model yielded no statistically significant correlations between EP productivity and patient experience, and the path analysis failed to show a relationship between the variables. We found no correlation between EP productivity and the patient experience.

  8. The correlation between dysphagia and involvement of the ambiguous nucleus on MRI in acute-phase lateral medullary syndrome

    International Nuclear Information System (INIS)

    Kurono, Hiroko; Uesaka, Yoshikazu; Kunimoto, Masanari; Imafuku, Ichirou

    2006-01-01

    In this study, the clinical features and MRI findings of 21 patients admitted for acute lateral medullary syndrome, including 10 patients with dysphagia, were examined. According to Cytoarchitecture of the Human Brain Stem (Olszewski, J and Baxter, D), MRI-identified lesions were classified into four groups based on their location (upper, middle-upper, middle-lower, and lower parts of the medulla oblongata). We also examined whether each lesion involved the ambiguous nucleus (AN). We then studied the correlation between dysphagia and involvement of the AN. Ten patients had dysphagia, which improved very quickly in all but one. In the horizontal plane, lesions of all patients with dysphagia exhibited AN involvement, suggesting that dysphagia is strongly correlated with AN involvement. Among the 8 patients with lesions in the upper part of the medulla oblongata, the lesions of 7 patients included the AN, and 6 of those 7 patients had dysphagia. Among the 5 patients with lesions in the middle-upper part of the medulla oblongata, the lesions of two contained the AN, and one of those two patients had dysphagia. Among the 6 patients with lesions in the middle-lower part of the medulla oblongata, all lesions contained the AN, but only 3 of the patients exhibited dysphagia. In both patients who had lesions in the lower part of the medulla oblongata, the lesions did not include the AN and neither patient had dysphagia. Patients who had lesions involving the AN in the rostral part of the medulla oblongata were more likely to have dysphagia than the other patients. On the other hand, half of the patients with lesions involving the AN in the middle-lower part of the medulla oblongata did not have dysphagia. This might suggest that the caudal part of the AN has little involvement in the mechanisms of dysphagia. (author)

  9. Wave-Particle Interactions Involving Correlated Electron Bursts and Whistler Chorus in Earth's Radiation Belts

    Science.gov (United States)

    Echterling, N.; Schriver, D.; Roeder, J. L.; Fennell, J. F.

    2017-12-01

    During the recovery phase of substorm plasma injections, the Van Allen Probes commonly observe events of quasi-periodic energetic electron bursts correlating with simultaneously detected upper-band, whistler-mode chorus emissions. These electron bursts exhibit narrow ranges of pitch angles (75-80° and 100-105°) and energies (20-40 keV). Electron cyclotron harmonic (ECH) emissions are also commonly detected, but typically do not display correlation with the electron bursts. To examine sources of free energy and the generation of these wave emissions, an observed electron velocity distribution on January 13, 2013 is used as the starting condition for a particle in cell (PIC) simulation. Effects of temperature anisotropy (perpendicular temperature greater than parallel temperature), the presence of a loss cone and a cold electron population on the generation of whistler and ECH waves are examined to understand wave generation and nonlinear interactions with the particle population. These nonlinear interactions produce energy diffusion along with strong pitch angle scattering into the loss cone on the order of milliseconds, which is faster than a typical bounce period of seconds. To examine the quasi-periodic nature of the electron bursts, a loss-cone recycling technique is implemented to model the effects of the periodic emptying of the loss cone and electron injection on the growth of whistler and ECH waves. The results of the simulations are compared to the Van Allen Probe observations to determine electron acceleration, heating and transport in Earth's radiation belts due to wave-particle interactions.

  10. Experiences of service users involved in recruitment for nursing courses: A phenomenological research study.

    Science.gov (United States)

    Stevens, Katie; Bernal, Cathy; Devis, Kate; Southgate, Andrew

    2017-11-01

    The aim of this study was to gain insight into service users' experiences of participating in recruitment for Adult, Mental Health and Child nursing studies at the authors' university; to establish potential motivations behind such participation; and to make suggestions for improved future practice. The involvement of service users in nurse education and recruitment has for some years been required by the Nursing and Midwifery Council, but there is a dearth of publications on the meaning of that involvement to participating service users. It is hoped that this study will contribute to this body of knowledge. A phenomenological approach was selected, field-specific focus groups of service users being facilitated using a semi-structured interview format; these were audio recorded and transcribed. The data was analysed using thematic analysis. Participation was subject to the service users having been involved in recruitment to nursing studies at the authors' university and the focus groups took place either at the university or at the child participants' school. Themes identified demonstrated largely positive experiences and a sense of meaningful involvement for all concerned. Findings indicated a close link between the values of the participants and those of the wider NHS, benefits to a sense of wellbeing and achievement, as well as the need for greater ownership of the recruitment process by service users. Potential lessons for academics wishing to promote greater service user involvement in student recruitment are articulated. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Neurobehavioral and neurometabolic (SPECT) correlates of paranormal information: involvement of the right hemisphere and its sensitivity to weak complex magnetic fields.

    Science.gov (United States)

    Roll, W G; Persinger, M A; Webster, D L; Tiller, S G; Cook, C M

    2002-02-01

    Experiments were designed to help elucidate the neurophysiological correlates for the experiences reported by Sean Harribance. For most of his life he has routinely experienced "flashes of images" of objects that were hidden and of accurate personal information concerning people with whom he was not familiar. The specificity of details for target pictures of people was correlated positively with the proportion of occipital alpha activity. Results from a complete neuropsychological assessment, Single Photon Emission Computed Tomography (SPECT), and screening electroencephalography suggested that his experiences were associated with increased activity within the parietal lobe and occipital regions of the right hemisphere. Sensed presences (subjectively localized to his left side) were evoked when weak, magnetic fields, whose temporal structure simulated long-term potentiation in the hippocampus, were applied over his right temporoparietal lobes. These results suggest that the phenomena attributed to paranormal or "extrasensory" processes are correlated quantitatively with morphological and functional anomalies involving the right parietotemporal cortices (or its thalamic inputs) and the hippocampal formation.

  12. Packages of participation: Swedish employees' experience of Lean depends on how they are involved.

    Science.gov (United States)

    Brännmark, Mikael; Holden, Richard J

    2013-01-01

    Lean Production is a dominant approach in Swedish and global manufacturing and service industries. Studies of Lean's employee effects are few and contradictory. Employee effects from Lean are likely not uniform. This paper investigates the effect of employees' participation on their experiences of Lean. This study investigated how different packages of employee participation in Lean affected manufacturing workers' experiences of Lean. During 2008-2011, qualitative and quantitative data were collected from Swedish manufacturing companies participating in the national Swedish Lean Production program Produktionslyftet. Data from 129 surveys (28 companies), 39 semi-structured interviews, and 30 reports were analyzed. In the main analysis, comparisons were made of the survey-reported Lean experiences of employees in three groups: temporary group employees (N = 36), who participated in Lean mostly through intermittent projects; continuous group employees (N = 69), who participated through standing improvement groups; and combined group employees (N = 24), who participated in both ways. Continuous group employees had the most positive experience of Lean, followed by the combined group. Temporary group employees had the least positive experiences, being less likely than their counterparts to report that Lean improved teamwork, occupational safety, and change-related learning, decision making, and authority. These findings support the importance of continuous, structured opportunities for participation but raise the possibility that more participation may result in greater workload and role overload, mitigating some benefits of employee involvement. Consequently, companies should consider involving employees in change efforts but should attend to the specific design of participation activities.

  13. Breast cancer survivors involved in vigorous team physical activity: psychosocial correlates of maintenance participation.

    Science.gov (United States)

    Culos-Reed, S Nicole; Shields, Christopher; Brawley, Lawrence R

    2005-07-01

    Physical activity is increasingly being promoted as a means to achieve both physical and psychological benefits for cancer survivors. For women with breast cancer, one sport growing in popularity is dragon boating. The purpose of the present investigation was to examine the psychosocial correlates of dragon boat participation over the course of a season. Six crews completed the baseline (early-season) assessment (n = 109) and late-season assessments (n = 56). The self-report questionnaire completed at both time points included an assessment of the theory of planned behaviour variables, quality of life, cohesion, and physical activity levels. A prospective examination of the TPB variables revealed attitude at early season as the only significant predictor of behavioural intentions 12 weeks later at late season (R2 adjusted = 0.27, p cohesive at a level similar to that for female sport teams among the asymptomatic population. As well, participants' health-related quality of life was similar to normal, healthy women of similar age for both mental and physical health. Copyright 2004 John Wiley & Sons, Ltd.

  14. Narrative transportation and product involvement : how narrativity factors are used to enchance transportive experience in advertising for high vs. low involvement products

    OpenAIRE

    Phusapan, Panida

    2013-01-01

    This paper examines and presents how narrativity factors are used to enhance consumers‟ transportive experience when advertising for high and low involvement products. It specifically looks at processing experiences among Thai online consumers when viewing TV commercials available on a YouTube channel. The paper brings the theory of product involvement into a field of narrative transportation. Results show that narrativity factors should be used with the right balance across all narrativity l...

  15. Practices and Experience in Stakeholder Involvement for Post-nuclear Emergency Management - Summary of the workshop

    International Nuclear Information System (INIS)

    Anon.

    2011-01-01

    One of the most important aspects of post-accident consequence management is the involvement of stakeholders: in the planning, preparation and execution as well as in sustaining efforts over the long term. Having recognised the significance of stakeholder participation in several International Nuclear Emergency Exercises (INEX), the NEA Committee on Radiation Protection and Public Health (CRPPH) decided to organise the Practices and Experience in Stakeholder Involvement for Post-nuclear Emergency Management Workshop to explore these issues. This summary highlights the key issues discussed during the workshop, which brought together 75 emergency management and communication specialists from 16 countries. In light of the accident at the Fukushima Daiichi nuclear power plant, the experience shared during this workshop will be central to further improving national emergency management arrangements

  16. Co-researching with people with learning disabilities: an experience of involvement in qualitative data analysis.

    Science.gov (United States)

    Tuffrey-Wijne, Irene; Butler, Gary

    2010-06-01

    People with learning disabilities have been included in research as co-researchers since the 1990s. However, there is limited literature about the processes of involving people with learning disabilities in the more intellectual and analytical stages of the research process. To examine the potential contribution of people with learning disabilities to data analysis in qualitative research. This article is a reflection on one research experience. The two authors include one researcher with and one without learning disabilities. They each describe their experience and understanding of user involvement in analysing the data of an ethnographic study of people with learning disabilities who had cancer. The researcher with learning disabilities was given extensive vignettes and extracts from the research field notes, and was supported to extract themes, which were cross-compared with the analysis of other members of the research team. The researcher with learning disabilities coped well with the emotive content of the data and with the additional support provided, he was able to extract themes that added validity to the overall analysis. His contribution complemented those of the other members of the research team. There were unexpected benefits, in particular, in terms of a more reciprocal and supportive relationship between the two researchers. It is possible and valuable to extend involvement to data analysis, but to avoid tokenism and maintain academic rigour, there must be a clear rationale for such involvement. Extra support, time and costs must be planned for.

  17. Involvement of abscisic acid in correlative control of flower abscission in soybean

    International Nuclear Information System (INIS)

    Yarrow, G.L.

    1985-01-01

    Studies were carried out in three parts: (1) analysis of endogenous abscisic acid (ABA) in abscising and non-abscising flowers, (2) partitioning of radio-labelled ABA and photoassimilates within the soybean raceme, and (3) shading experiments, wherein endogenous levels, metabolism and partitioning of ABA were determined. Endogenous concentrations of ABA failed to show any consistent relationship to abscission of soybean flowers. Partitioning of radiolabelled ABA and photoassimilates displayed consistently higher sink strengths (% DPM) for both 3 H-ABA and 14 C-photoassimilates for non-abscising flowers than for abscising flowers within control racemes. Shading flowers with aluminum foil, 48 hrs prior to sampling, resulted in lowered endogenous ABA concentrations at 12, 17 and 22 days after anthesis (DAA), but not at 0 or 4 DAA. No differences were found in the catabolism of 3 H-ABA between shaded (abscising) and non-shaded (non-abscising) flowers. Reduced partitioning of ABA and photoassimilates to shaded flowers resulted when shades were applied at 0, 4, 12, and 17 DAA, but not at 22 DAA

  18. Review and proposal for heat transfer predictions at supercritical water conditions using existing correlations and experiments

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, Wadim, E-mail: wadim.jaeger@kit.edu [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, DE-76344 Eggenstein-Leopoldshafen (Germany); Sanchez Espinoza, Victor Hugo [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, DE-76344 Eggenstein-Leopoldshafen (Germany); Hurtado, Antonio [Technical University of Dresden, Institute of Power Engineering, DE-01062 Dresden (Germany)

    2011-06-15

    Highlights: > Implementation of heat transfer correlations for supercritical water into TRACE. > Simulation of several heat transfer experiments with modified TRACE version. > Most correlations are not able to reproduce the experimental results. > Bishop, Sandberg and Tong correlation is most suitable for TRACE applications. - Abstract: This paper summarizes the activities of the TRACE code validation at the Institute for Neutron Physics and Reactor Technology related to supercritical water conditions. In particular, the providing of the thermo physical properties and its appropriate use in the wall-to-fluid heat transfer models in the frame of the TRACE code is the object of this investigation. In a first step, the thermo physical properties of the original TRACE code were modified in order to account for supercritical conditions. In a second step, existing Nusselt correlations were reviewed and implemented into TRACE and available experiments were simulated to identify the most suitable Nusselt correlation(s).

  19. Review and proposal for heat transfer predictions at supercritical water conditions using existing correlations and experiments

    International Nuclear Information System (INIS)

    Jaeger, Wadim; Sanchez Espinoza, Victor Hugo; Hurtado, Antonio

    2011-01-01

    Highlights: → Implementation of heat transfer correlations for supercritical water into TRACE. → Simulation of several heat transfer experiments with modified TRACE version. → Most correlations are not able to reproduce the experimental results. → Bishop, Sandberg and Tong correlation is most suitable for TRACE applications. - Abstract: This paper summarizes the activities of the TRACE code validation at the Institute for Neutron Physics and Reactor Technology related to supercritical water conditions. In particular, the providing of the thermo physical properties and its appropriate use in the wall-to-fluid heat transfer models in the frame of the TRACE code is the object of this investigation. In a first step, the thermo physical properties of the original TRACE code were modified in order to account for supercritical conditions. In a second step, existing Nusselt correlations were reviewed and implemented into TRACE and available experiments were simulated to identify the most suitable Nusselt correlation(s).

  20. Packages of participation: Swedish employees’ experience of Lean depends on how they are involved

    Science.gov (United States)

    Brännmark, Mikael; Holden, Richard J.

    2013-01-01

    Background Lean Production is a dominant approach in Swedish and global manufacturing and service industries. Studies of Lean’s employee effects are few and contradictory. Purpose Employee effects from Lean are likely not uniform. This paper investigates the effect of employees' participation on their experiences of Lean. Method This study investigated how different packages of employee participation in Lean affected manufacturing workers’ experiences of Lean. During 2008–2011, qualitative and quantitative data were collected from Swedish manufacturing companies participating in the national Swedish Lean Production program Produktionslyftet. Data from 129 surveys (28 companies), 39 semi-structured interviews, and 30 reports were analyzed. In the main analysis, comparisons were made of the survey-reported Lean experiences of employees in three groups: temporary group employees (N = 36), who participated in Lean mostly through intermittent projects; continuous group employees (N = 69), who participated through standing improvement groups; and combined group employees (N = 24), who participated in both ways. Results Continuous group employees had the most positive experience of Lean, followed by the combined group. Temporary group employees had the least positive experiences, being less likely than their counterparts to report that Lean improved teamwork, occupational safety, and change-related learning, decision making, and authority. Conclusions These findings support the importance of continuous, structured opportunities for participation but raise the possibility that more participation may result in greater workload and role overload, mitigating some benefits of employee involvement. Consequently, companies should consider involving employees in change efforts but should attend to the specific design of participation activities. PMID:24665370

  1. Family members' involvement in psychiatric care: experiences of the healthcare professionals' approach and feeling of alienation.

    Science.gov (United States)

    Ewertzon, M; Lützén, K; Svensson, E; Andershed, B

    2010-06-01

    The involvement of family members in psychiatric care is important for the recovery of persons with psychotic disorders and subsequently reduces the burden on the family. Earlier qualitative studies suggest that the participation of family members can be limited by how they experience the professionals' approach, which suggests a connection to the concept of alienation. Thus, the aim of this study was in a national sample investigate family members' experiences of the psychiatric health care professionals' approach. Data were collected by the Family Involvement and Alienation Questionnaire. The median level and quartiles were used to describe the distributions and data were analysed with non-parametric statistical methods. Seventy family members of persons receiving psychiatric care participated in the study. The results indicate that a majority of the participants respond that they have experiencing a negative approach from the professionals, indicating lack of confirmation and cooperation. The results also indicate that a majority of the participants felt powerlessness and social isolation in the care being provided, indicating feelings of alienation. A significant but weak association was found between the family members' experiences of the professionals' approach and their feelings of alienation.

  2. Differential Susceptibility Experiments: Going beyond Correlational Evidence--Comment on beyond Mental Health, Differential Susceptibility Articles

    Science.gov (United States)

    van IJzendoorn, Marinus H.; Bakermans-Kranenburg, Marian J.

    2012-01-01

    Reviewing the studies on differential susceptibility presented in this section, we argue that the time is ripe to go beyond correlational designs to differential susceptibility experiments. In such experiments, randomization prevents hidden moderator effects on the environment and guarantees the independence of moderator and outcome, while the…

  3. Simultaneous acquisition for T2 -T2 Exchange and T1 -T2 correlation NMR experiments

    Science.gov (United States)

    Montrazi, Elton T.; Lucas-Oliveira, Everton; Araujo-Ferreira, Arthur G.; Barsi-Andreeta, Mariane; Bonagamba, Tito J.

    2018-04-01

    The NMR measurements of longitudinal and transverse relaxation times and its multidimensional correlations provide useful information about molecular dynamics. However, these experiments are very time-consuming, and many researchers proposed faster experiments to reduce this issue. This paper presents a new way to simultaneously perform T2 -T2 Exchange and T1 -T2 correlation experiments by taking the advantage of the storage time and the two steps phase cycling used for running the relaxation exchange experiment. The data corresponding to each step is either summed or subtracted to produce the T2 -T2 and T1 -T2 data, enhancing the information obtained while maintaining the experiment duration. Comparing the results from this technique with traditional NMR experiments it was possible to validate the method.

  4. Measuring spirituality as a universal human experience: development of the Spiritual Attitude and Involvement List (SAIL).

    Science.gov (United States)

    de Jager Meezenbroek, Eltica; Garssen, Bert; Van den Berg, Machteld; Tuytel, Gerwi; Van Dierendonck, Dirk; Visser, Adriaan; Schaufeli, Wilmar B

    2012-01-01

    Many cancer patients experience spirituality as highly supportive while coping with their disease. Most research as well as most questionnaires in this field is religious orientated. The Spiritual Attitude and Involvement List was developed to enable research on spirituality among religious and nonreligious people. It consists of seven subscales that measure connectedness with oneself, with others and nature, and with the transcendent. Among a student, a healthy population, a healthy interested, a curative cancer, and a palliative cancer sample factorial, convergent and discriminant validity were demonstrated, as well as adequate internal consistency and test-retest reliability.

  5. Selection during crop diversification involves correlated evolution of the circadian clock and ecophysiological traits in Brassica rapa.

    Science.gov (United States)

    Yarkhunova, Yulia; Edwards, Christine E; Ewers, Brent E; Baker, Robert L; Aston, Timothy Llewellyn; McClung, C Robertson; Lou, Ping; Weinig, Cynthia

    2016-04-01

    Crop selection often leads to dramatic morphological diversification, in which allocation to the harvestable component increases. Shifts in allocation are predicted to impact (as well as rely on) physiological traits; yet, little is known about the evolution of gas exchange and related anatomical features during crop diversification. In Brassica rapa, we tested for physiological differentiation among three crop morphotypes (leaf, turnip, and oilseed) and for correlated evolution of circadian, gas exchange, and phenological traits. We also examined internal and surficial leaf anatomical features and biochemical limits to photosynthesis. Crop types differed in gas exchange; oilseed varieties had higher net carbon assimilation and stomatal conductance relative to vegetable types. Phylogenetically independent contrasts indicated correlated evolution between circadian traits and both gas exchange and biomass accumulation; shifts to shorter circadian period (closer to 24 h) between phylogenetic nodes are associated with higher stomatal conductance, lower photosynthetic rate (when CO2 supply is factored out), and lower biomass accumulation. Crop type differences in gas exchange are also associated with stomatal density, epidermal thickness, numbers of palisade layers, and biochemical limits to photosynthesis. Brassica crop diversification involves correlated evolution of circadian and physiological traits, which is potentially relevant to understanding mechanistic targets for crop improvement. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

  6. High Frequency of CD8 Positive Lymphocyte Infiltration Correlates with Lack of Lymph Node Involvement in Early Rectal Cancer

    Directory of Open Access Journals (Sweden)

    Silvio Däster

    2014-01-01

    Full Text Available Aims. A trend towards local excision of early rectal cancers has prompted us to investigate if immunoprofiling might help in predicting lymph node involvement in this subgroup. Methods. A tissue microarray of 126 biopsies of early rectal cancer (T1 and T2 was stained for several immunomarkers of the innate and the adaptive immune response. Patients’ survival and nodal status were analyzed and correlated with infiltration of the different immune cells. Results. Of all tested markers, only CD8 (P=0.005 and TIA-1 (P=0.05 were significantly more frequently detectable in early rectal cancer biopsies of node negative as compared to node positive patients. Although these two immunomarkers did not display prognostic effect “per se,” CD8+ and, marginally, TIA-1 T cell infiltration could predict nodal involvement in univariate logistic regression analysis (OR 0.994; 95% CI 0.992–0.996; P=0.009 and OR 0.988; 95% CI 0.984–0.994; P=0.05, resp.. An algorithm significantly predicting the nodal status in early rectal cancer based on CD8 together with vascular invasion and tumor border configuration could be calculated (P<0.00001. Conclusion. Our data indicate that in early rectal cancers absence of CD8+ T-cell infiltration helps in predicting patients’ nodal involvement.

  7. Older peoples experiences involving the decision to transition to an aged care home

    Directory of Open Access Journals (Sweden)

    Zamanzadeh Vahid

    2016-08-01

    Full Text Available The decision to relocate to an aged care home can is important change in older adults live but little attention has been paid to their experiences of this decision. The study explored older people’s experiences involving the decision to transition to an aged care home. Data were obtained via semi-structured interviews with 17 participants, which were content analyzed. Results: Transition motives, ambiguity, participation in decision making and decision making meaning were four themes extracted through data analysis. Conclusions: In the main, the decision to transition to an aged care home had been made without the older person’s participation. In addition, due to inadequate information about aged care home services, participants experienced a great deal of ambiguity in the decision-making process. Moreover, transition into aged care homes had different meaning for the participants. The findings suggest that far greater emphasis must be placed on having older people involved in the decision to move into residential aged care, providing them with more information about service offerings and making psychological support accessible to them prior to and following transition to the home

  8. Experience of Public Involvement in Canada Presented to the Forum for Stakeholder Confidence

    International Nuclear Information System (INIS)

    Facella, Jo-Ann; Patton, Pat

    2008-01-01

    Pat Patton of NWMO, Canada, summarised the experiences of the organisation's three-year study aimed at identifying a broadly supported approach to managing Canada's nuclear fuel waste. The starting point of the study was the recognition that citizen perception of safety and acceptability are strongly interrelated, therefore understanding and addressing the social dimension of safety would be critical for finding a socially acceptable RWM approach. An iterative and collaborative dialogue was conducted between specialists and citizens to both identify how safety is to be assessed and to carry out the assessment. First, objectives, values and ethical principles were defined, which formed the basis for the criteria of selecting a preferred RWM approach. The dialogue revealed that adaptability of the management approach to new information and technological advancement is a key requirement. Continuous learning, RD and D, and citizen involvement over the course of implementation were also identified as important components of the management approach. Ms Patton presented an illustrative model for public involvement during the implementation process. According to the model, implementation would be a multi-stage process with a continuous interaction between scientific and technical specialists, potentially affected communities and the implementer. Finally, Ms Patton outlined some key challenges for future dialogues between non-specialists and experts, including the development of tools for involving citizens in increasingly more knowledge-intensive areas and communicating research results which address issues highlighted by citizens

  9. Middle Eastern mothers in Sweden, their experiences of the maternal health service and their partner's involvement

    Directory of Open Access Journals (Sweden)

    D Karlsson Elisabeth

    2007-10-01

    Full Text Available Abstract Background Traditional patterns relating to how to handle pregnancy and birth are often challenged due to migration. The purpose of this study was to describe Middle Eastern mothers' experiences of the maternal health care services in Sweden and the involvement of their male partner. Methods Thirteen immigrant mothers from the Middle East who had used the maternal health services in Sweden were interviewed using focus group discussions and individual interviews. These were taped, transcribed and analysed according to Content analysis. Results The four main categories that developed were: • Access to the professional midwife • Useful counselling • Stable motherhood in transition • Being a family living in a different culture Conclusion According to the respondents in this study, understanding the woman's native language or her culture was not vital to develop a good relationship with the midwife. Instead the immigrant woman developed trust in the midwife based on the knowledge and the empathy the midwife imparted. Increasing the amount of first trimester antenatal visits could avoid spontaneous visits to the emergency clinic. There was a greater need for involvement and support by the father during the perinatal period, such as caring for older children and carrying out household chores since the mothers' earlier female network was often lost. Clinical implications There is a need to involve immigrant parents in the available parental education in order to prepare them for parenthood in their new country as well as to explore their altered family situation. Collecting immigrant women and their partner's, experiences of maternal health care services offers a possibility to improve the existing care, both in content, access and availability where the timing of visits and content require further evaluation.

  10. Demonstrating the unit hydrograph and flow routing processes involving active student participation - a university lecture experiment

    Science.gov (United States)

    Schulz, Karsten; Burgholzer, Reinhard; Klotz, Daniel; Wesemann, Johannes; Herrnegger, Mathew

    2018-05-01

    The unit hydrograph (UH) has been one of the most widely employed hydrological modelling techniques to predict rainfall-runoff behaviour of hydrological catchments, and is still used to this day. Its concept is based on the idea that a unit of effective precipitation per time unit (e.g. mm h-1) will always lead to a specific catchment response in runoff. Given its relevance, the UH is an important topic that is addressed in most (engineering) hydrology courses at all academic levels. While the principles of the UH seem to be simple and easy to understand, teaching experiences in the past suggest strong difficulties in students' perception of the UH theory and application. In order to facilitate a deeper understanding of the theory and application of the UH for students, we developed a simple and cheap lecture theatre experiment which involved active student participation. The seating of the students in the lecture theatre represented the hydrological catchment in its size and form. A set of plastic balls, prepared with a piece of magnetic strip to be tacked to any white/black board, each represented a unit amount of effective precipitation. The balls are evenly distributed over the lecture theatre and routed by some given rules down the catchment to the catchment outlet, where the resulting hydrograph is monitored and illustrated at the black/white board. The experiment allowed an illustration of the underlying principles of the UH, including stationarity, linearity, and superposition of the generated runoff and subsequent routing. In addition, some variations of the experimental setup extended the UH concept to demonstrate the impact of elevation, different runoff regimes, and non-uniform precipitation events on the resulting hydrograph. In summary, our own experience in the classroom, a first set of student exams, as well as student feedback and formal evaluation suggest that the integration of such an experiment deepened the learning experience by active

  11. Midwifery students experience of teamwork projects involving mark-related peer feedback.

    Science.gov (United States)

    Hastie, Carolyn R; Fahy, Kathleen M; Parratt, Jenny A; Grace, Sandra

    2016-06-01

    Lack of teamwork skills among health care professionals endangers patients and enables workplace bullying. Individual teamwork skills are increasingly being assessed in the undergraduate health courses but rarely defined, made explicit or taught. To remedy these deficiencies we introduced a longitudinal educational strategy across all three years of the Bachelor of Midwifery program. To report on students' experiences of engaging in team based assignments which involved mark-related peer feedback. Stories of midwifery students' experiences were collected from 17 participants across the three years of the degree. These were transcribed and analysed thematically and interpreted using feminist collaborative conversations. Most participants reported being in well-functioning teams and enjoyed the experience; they spoke of 'we' and said 'Everyone was on Board'. Students in poorly functioning teams spoke of 'I' and 'they'. These students complained about the poor performance of others but they didn't speak up because they 'didn't want to make waves' and they didn't have the skills to be able to confidently manage conflict. All participants agreed 'Peer-related marks cause mayhem'. Teamwork skills should be specifically taught and assessed. These skills take time to develop. Students, therefore, should be engaged in a teamwork assignment in each semester of the entire program. Peer feedback should be moderated by the teacher and not directly related to marks. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  12. Correlation of adverse childhood experiences with psychiatric disorders and aggressiveness in adulthood

    Directory of Open Access Journals (Sweden)

    Samardžić Ljiljana

    2010-01-01

    Full Text Available Background/Aim. Consequences of individual adverse childhood experiences for adult mental health have been precisely studied during past decades. The focus of past research was mainly on childhood maltreatment and neglect. The aim of this paper was to determine association between multiple adverse childhood experiences and psychiatric disorders, as well as their correlation to the degree and type of aggressiveness in adult psychiatric patients. Methods. One hundred and thirteen psychiatric outpatients were divided into three diagnostic groups: psychotics, non-psychotics and alcoholics and compared with fourty healthy individuals. Adverse childhood experiences data were gathered retrospectively, using the Adverse childhood experiences questionnaire and explanatory interview. Aggressiveness was assessed using Buss-Perry Aggression Questionnaire. The Student's t test, ANOVA and correlational analysis were used for evaluation of statistical significance of differences among the groups. A value p < 0.05 was considered statistically significant. Results. Our results showed that the mean number of adverse childhood experiences in each group of psychiatric patients, as well as in the whole group of patients, was statistically significantly higher than in the group of healthy individuals (p < 0.001; there was a statistically significant difference in score of physical aggressiveness between the patients exposed to adverse childhood experiences and those who were not exposed to them (p < 0.05; scores of physical aggressiveness were in positive correlation with the number of adverse childhood experiences (p < 0.05. The highest mean score of adverse childhood experiences was evidenced in the group of patients with psychotic disorders. Conclusion. Multiple adverse childhood experiences are significantly associated with psychotic disorders, nonpsychotic disorders and alcohol dependence in adulthood and their presence is important morbidity risk factor for

  13. Reverse correlation of Jab1 and Smad4 in PANC-1 cells involved in the pathogenesis of pancreatic cancer.

    Science.gov (United States)

    Li, Jun; Gu, Zhuoyu; Li, Siyuan; Xiao, Zhiwei; Sun, Kan

    2015-01-01

    Steps in the genetic basis of pancreatic cancer (PC) have been recently identified, however, Studies focusing on the relationship between Jab1 and Smad4 in PC are rarely reported. This study was performed to examine the expression patterns and association of Jab1 and Smad4 in PC cells for gaining a further understanding of PC pathogenesis. Human pancreatic cancer cell line PANC-1 cells were infected with retrovirus vector containing GFP, HA-Jab1, siGFP, and siJab1 respectively. The expression of Jab1 and Smad4 in PANC-1 cells was analyzed by Western blot and immunocytochemistry. Subsequently, the effect of overexpression of Jab1 on cell proliferation inhibition mediated by TGF-β was examined with MTT colorimetry. The expression of Smad4 in PANC-1 cells was inhibited after the overexpression of Jab1. Inversely, the expression of Smad4 was increased after the down-regulation of Jab1 silenced by SiRNA. Smad4 expression in PANC-1 cells was negatively correlated with Jab1 expression. In addition, the cell proliferation inhibitory effect induced by TGF-β in PANC-1 cells was attenuated after the overexpression of Jab1. The reverse correlation of Jab1 and Smad4 in PANC-1 cells may be involved in the Pathogenesis of PC. Jab1 can cause degradation of Smad4 via TGF-β signal pathway, consequently contributing to the proliferation of PC cells.

  14. Correlation of atherosclerotic changes in peripheral arteries with pathological involvement of aortic arch in coronary bypass patients

    Directory of Open Access Journals (Sweden)

    Eshraghi N

    2010-10-01

    Full Text Available "nBackground: A correlation between coronary artery disease (CAD and atherosclerosis of peripheral arteries and the determination of noninvasive indexes for its existence and extent have been sought by many researchers. Some studies report that the intima-media thickness (IMT of peripheral arteries could play this role. This study evaluated the correlation between the IMTs of common carotid and common femoral arteries and the degree of atherosclerosis in aortic arch and to evaluate the severity of CAD in candidates of coronary artery bypass grafting (CABG."n "nMethods: In a cross-sectional analytic-descriptive study, The severity of CAD, the grade of atherosclerosis of the aortic arch, and the IMTs of the common carotid and common femoral arteries were determined."n "nResults: There was a significant weak positive correlation between the IMT of common carotid artery (ρ = 0.193, p = 0.039 and common femoral artery (ρ = 0.206, p = 0.028 with the number of involved carotid vessels; the mean of these two parameters was not significantly different between the three CAD groups. There was not any significant relation between the IMTs of common carotid and common femoral arteries with the severity of atherosclerosis in the aortic arch too. There was not any significant relation between the presences of atherosclerotic plaque in the common carotid or the common femoral arteries with the severity of CAD. The severe atherosclerosis of the aortic arch was significantly higher in patients with three vessel disease."n "nConclusion: According to our results, the IMTs of common carotid and/or common femoral arteries may increase with the severity of CAD; however, these parameters are not a surrogate for predicting the CAD severity.

  15. Recent Operating Experience involving Power Electronics Failure in Korea Nuclear Power Plants

    International Nuclear Information System (INIS)

    Lee, Jaedo

    2015-01-01

    Recently, modern power electronics devices for electrical component were steadily increased in electrical systems which used for main power control and protection. To upgrade the system reliability we recommended the redundancy for electrical equipment trip system. The past several years, Korean Nuclear power plants have changed the electrical control and protection systems (Auto Voltage Regulator, Power Protection Relay) for main generator and main power protection relay systems. In this paper we deal with operating experience involving modern solid state power electronics failure in Korean nuclear power plants. One of the failures we will discuss the degraded phenomenon of power electronics device for CEDMCS(Control Element Drive Mechanism Control System). As the result of the failure we concerned about the modification for trip source of main generator excitation systems and others. We present an interesting issue for modern solid state devices (IGBT, Thyristors). (authors)

  16. Correlation of Endostatin and Tissue Inhibitor of Metalloproteinases 2 (TIMP2 Serum Levels With Cardiovascular Involvement in Systemic Sclerosis Patients

    Directory of Open Access Journals (Sweden)

    Bozena Dziankowska-Bartkowiak

    2005-01-01

    pathogenesis of SSc. Heart fibrosis is one of the most important prognostic factors in SSc patients. So, the aim of our study was to examine cardiovascular dysfunction in SSc patients and its correlation with serum levels of vascular endothelial growth factor (VEGF, endostatin, and tissue inhibitor of metalloproteinase 2 (TIMP2. The study group comprised 34 patients (19 with limited scleroderma (lSSc and 15 with diffuse scleroderma (dSSc. The control group consisted of 20 healthy persons, age and sex matched. Internal organ involvement was assessed on the basis of specialist procedures. Serum VEGF, endostatin, and TIMP2 levels were evaluated by ELISA. We found cardiovascular changes in 15 patients with SSc (8 with lSSc and 7 with dSSc. The observed symptoms were of different characters and also coexisted with each other. Higher endostatin serum levels in all systemic sclerosis patients in comparison to the control group were demonstrated (P<.05. Also higher serum levels of endostatin and TIMP2 were observed in patients with cardiovascular changes in comparison to the patients without such changes (P<.05. The obtained results support the notion that angiogenesis and fibrosis disturbances may play an important role in SSc. Evaluation of endostatin and TIMP2 serum levels seems to be one of the noninvasive, helpful examinations of heart involvement in the course of systemic sclerosis.

  17. A longitudinal online interprofessional education experience involving family nurse practitioner students and pharmacy students.

    Science.gov (United States)

    Collins, Andrea; Broeseker, Amy; Cunningham, Jill; Cortes, Cyndi; Beall, Jennifer; Bigham, Amy; Chang, Jongwha

    2017-03-01

    Interprofessional education (IPE) continues to gain traction worldwide. Challenges integrating IPE into health profession programmes include finding convenient times, meeting spaces, and level-appropriate assignments for each profession. This article describes the implementation of a 21-month prospective cohort study pilot programme for the Master of Science in nursing family nurse practitioner (FNP) and doctor of pharmacy (PharmD) students at a private university in the United States. This IPE experience utilised a blended approach for the learning activities; these students had initial and final sessions where they met face-to-face, with asynchronous online activities between these two sessions. The online assignments, discussions, and quizzes during the pilot programme involved topics such as antimicrobial stewardship, hormone replacement therapy, human papilloma virus vaccination, prenatal counselling, emergency contraception, and effects of the Affordable Care Act on practice. The results suggested that the FNP students held more favourable attitudes about online IPE and that the PharmD students reported having a clearer understanding of their own roles and those of the other participating healthcare students. However, the students also reported wanting more face-to-face interaction during their online IPE experience. Implications from this study suggest that effective online IPE can be supported by ensuring educational parity between students regarding the various topics discussed and a consistent approach of the required involvement for all student groups is needed. In addition, given the students desire for more face-to-face interaction, it may be beneficial to offer online IPE activities for a shorter time period. It is anticipated that this study may inform other programmes that are exploring innovative approaches to provide IPE to promote effective collaboration in patient care.

  18. Policy on manager involvement in work re-integration: managers' experiences in a Canadian setting.

    Science.gov (United States)

    Maiwald, Karin; Meershoek, Agnes; de Rijk, Angelique; Nijhuis, Frans J N

    2014-01-01

    In Canada and other countries, sickness absence among workers is a significant concern. Local return-to-work policies developed by both management and workers' representatives are preferred to tackle the problem. This article examines how managers perceive this local bipartite agreed upon return-to-work policy, wherein a social constructivist view on the policy process is taken. In-depth interviews were held with 10 managers on their experiences with execution of this policy in a Canadian healthcare organization. Interviews were transcribed verbatim and qualitative analyses were completed to gain deep insight into the managers' perspectives. Results show that the managers viewed themselves as a linchpin between the workplace and the worker. They did not feel heard by the other stakeholders, wrestled with worker's limitations, struggled getting plans adjusted and became overextended to meet return-to-work objectives. The study shows that the managers felt unable to meet the responsibilities the policy demanded and got less involved in the return-to-work process than this policy intended. RTW policy needs to balance on the one hand, flexibility to safeguard active involvement of managers and, on the other hand, strictness regarding taking responsibility by stakeholders, particularly the health care and re-integration professionals.

  19. Parent involvement in beginning primary school: Correlates and changes in involvement across the first two years of school in a New Zealand sample.

    Science.gov (United States)

    McDowall, Philippa S; Taumoepeau, Mele; Schaughency, Elizabeth

    2017-06-01

    This study described the relations of parents' and teachers' beliefs and attitudes to forms of parents' involvement in children's first two years of primary school. Parents of children in their first year of primary school (age 5) were recruited from 12 classrooms within four schools in New Zealand; 196 families participated in their child's first year, and 124 families continued to participate in their child's second school year. Parents completed the Family-Involvement Questionnaire, New Zealand, and we archivally collected parent-documented children's oral reading homework. Teachers' rated helpfulness of parents' involvement at school (level 2) and parents' rated teacher invitations to be involved and their perceived time and energy (level 1) contributed to school-based involvement in Year 1 in multilevel models, with parents' rated teacher invitations for involvement also found to predict Year 1 home-school communication in regression analyses. Contributors to Year 1 child-parent reading in multilevel models included level 1 predictors of two or more adults in the home and parents' perceived time and energy. Longitudinal analyses suggested both consistency and change in each form of involvement from Year 1 to Year 2, with increases in each form of involvement found to be associated with increases in parents' and/or teachers' views about involvement in Year 2 in cross-sectional time-series analyses. Implications for schools wanting to engage families are that parents' involvement in children's schooling may be influenced by parents' perceptions of their capacity, teachers' engagement efforts, and the school's climate for involvement. This is a special issue paper "Family Engagement in Education and Intervention". Copyright © 2017 Society for the Study of School Psychology. Published by Elsevier Ltd. All rights reserved.

  20. Assessments of CHF correlations based on full-scale rod bundle experiments

    International Nuclear Information System (INIS)

    Sardh, K.; Becker, K.M.

    1986-02-01

    In the present study the Barnett, the Becker, the Biasi, the CISE-4, the XN-1, the EPRI and the Bezrukov burnout correlations have been compared with burnout measurements obtained with full scale 81, 64, 36 and 37-rod bundles. The total power as well as the local power hypothesis was employed for the comparisons. The results clearly indicated that the Biasi and the CISE-4 correlations do not predict the burnout conditions in full-scale rod bundles. Since, these correlations yield non-conservative results their use in computer programs as for instance RELAP, TRAC or NORA should be avoided. Considering that the effects of spacers were not included in the predictions, the Becker and the Bezrukov correlations were in excellent agreement with the experimental data. However, it should be pointed out that the Bezrukov correlation only covered the 70 and 90 bar data, while the Becker correlation agreed with the experimental data in the whole pressure range between 30 and 90 bar. The Barnett, the XN-1 and the EPRI correlations were also in satisfactory agreement with the experiments. We therefore conclude that for predictions of the burnout conditions in full-scale BWR rod bundles the Becker correlation should be employed. (author)

  1. Estimating adhesive seed-dispersal distances : field experiments and correlated random walks

    NARCIS (Netherlands)

    Mouissie, AM; Lengkeek, W; van Diggelen, R

    1. In this study we aimed to estimate distance distributions of adhesively dispersed seeds and the factors that determine them. 2. Seed attachment and detachment were studied using field experiments with a real sheep, a sheep dummy and a cattle dummy. Seed-retention data were used in correlated

  2. Experiments tests of Bell's inequalities with pairs of low energy correlated photons

    International Nuclear Information System (INIS)

    Aspect, A.

    1986-01-01

    This paper reviews the essence of Bell's reasoning, the purpose of which is to convince the reader that a very natural way of understanding the EPR correlations is to complete quantum mechanics in the way considered by Bell. It is noted that Bell's theorem states a conflict between local supplementary parameters theories and certain quantum mechanical predictions. It yields a quantitative criterion for this conflict, that allows one to design sensitive experiments. These experiments are presented in the paper. It is concluded that the predictions of quantum mechanics in EPR-type situations are vindicated by the experiments

  3. Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling

    Science.gov (United States)

    Dietrich, Johannes W.; Müller, Patrick; Schiedat, Fabian; Schlömicher, Markus; Strauch, Justus; Chatzitomaris, Apostolos; Klein, Harald H.; Mügge, Andreas; Köhrle, Josef; Rijntjes, Eddy; Lehmphul, Ina

    2015-01-01

    Background Although hyperthyroidism predisposes to atrial fibrillation, previous trials have suggested decreased triiodothyronine (T3) concentrations to be associated with postoperative atrial fibrillation (POAF). Therapy with thyroid hormones (TH), however, did not reduce the risk of POAF. This study reevaluates the relation between thyroid hormone status, atrial electromechanical function and POAF. Methods Thirty-nine patients with sinus rhythm and no history of atrial fibrillation or thyroid disease undergoing cardiac surgery were prospectively enrolled. Serum concentrations of thyrotropin, free (F) and total (T) thyroxine (T4) and T3, reverse (r)T3, 3-iodothyronamine (3-T1AM) and 3,5-diiodothyronine (3,5-T2) were measured preoperatively, complemented by evaluation of echocardiographic and electrophysiological parameters of cardiac function. Holter-ECG and telemetry were used to screen for POAF for 10 days following cardiac surgery. Results Seven of 17 patients who developed POAF demonstrated nonthyroidal illness syndrome (NTIS; defined as low T3 and/or low T4 syndrome), compared to 2 of 22 (p < 0.05) patients who maintained sinus rhythm. In patients with POAF, serum FT3 concentrations were significantly decreased, but still within their reference ranges. 3,5-T2 concentrations directly correlated with rT3 concentrations and inversely correlated with FT3 concentrations. Furthermore, 3,5-T2 concentrations were significantly elevated in patients with NTIS and in subjects who eventually developed POAF. In multivariable logistic regression FT3, 3,5-T2, total atrial conduction time, left atrial volume index and Fas ligand were independent predictors of POAF. Conclusion This study confirms reduced FT3 concentrations in patients with POAF and is the first to report on elevated 3,5-T2 concentrations in cardiac NTIS. The pathogenesis of NTIS therefore seems to involve more differentiated allostatic mechanisms. PMID:26279999

  4. Comparison of condensation correlations in CATHARE for modelling isolation condenser experiment

    International Nuclear Information System (INIS)

    Sorjonen, J.; Kalli, H.

    1996-01-01

    CATHARE is a thermal-hydraulic computer code developed at the Centre d'Etudes Nucleaires de Grenoble (CENG) for nuclear power plant safety analysis. Behaviour of a new Cathare condensation correlation have been studied. The code has been applied to Isolation Condenser (IC) experiment conducted in PIPER-ONE facility. PIPER-ONE simulates a General Electric BWR-6 with volume and height scaling ratios 1/2200 and 1/1, respectively. The facility is installed at Dipartimento di Costruzioni Meccaniche e Nucleari of Pisa University. The facility was equipped with an once-through heat exchanger immersed in a pool of ambient temperature water, installed roughly 10 m above the core, in the aim to reproduce qualitatively the phenomenologies expected for Isolation Condenser in the Simplified BWR (SBWR). Experiment PO-IC-02 included two subsequent power levels with initial pressure of 5.1 MPa. The IC was active during the whole experiment except in the time period between the two different power levels. A previous calculation of above mentioned experiment by Cathare2 V1.3E showed some lacks in the condensation correlation of the code. A new correlation has been developed in Centre d'Etudes Nucleaires de Grenoble (CENG). The new calculation of the PO-IC-02 experiment by Cathare2 Vl.3U 1 with the new correlation gave results consistent with the experiment in the condensing zone of the IC. Also the overall pressure trend was reproduced with estimated heat losses to the environment. A comparison with previously obtained Relap5/Mod3. 1 results is also shown in the present document. (author) (18 refs.)

  5. Experiences of community pharmacists involved in the delivery of a specialist asthma service in Australia.

    Science.gov (United States)

    Emmerton, Lynne M; Smith, Lorraine; LeMay, Kate S; Krass, Ines; Saini, Bandana; Bosnic-Anticevich, Sinthia Z; Reddel, Helen K; Burton, Deborah L; Stewart, Kay; Armour, Carol L

    2012-06-18

    The role of community pharmacists in disease state management has been mooted for some years. Despite a number of trials of disease state management services, there is scant literature into the engagement of, and with, pharmacists in such trials. This paper reports pharmacists' feedback as providers of a Pharmacy Asthma Management Service (PAMS), a trial coordinated across four academic research centres in Australia in 2009. We also propose recommendations for optimal involvement of pharmacists in academic research. Feedback about the pharmacists' experiences was sought via their participation in either a focus group or telephone interview (for those unable to attend their scheduled focus group) at one of three time points. A semi-structured interview guide focused discussion on the pharmacists' training to provide the asthma service, their interactions with health professionals and patients as per the service protocol, and the future for this type of service. Focus groups were facilitated by two researchers, and the individual interviews were shared between three researchers, with data transcribed verbatim and analysed manually. Of 93 pharmacists who provided the PAMS, 25 were involved in a focus group and seven via telephone interview. All pharmacists approached agreed to provide feedback. In general, the pharmacists engaged with both the service and research components, and embraced their roles as innovators in the trial of a new service. Some experienced challenges in the recruitment of patients into the service and the amount of research-related documentation, and collaborative patient-centred relationships with GPs require further attention. Specific service components, such as the spirometry, were well received by the pharmacists and their patients. Professional rewards included satisfaction from their enhanced practice, and pharmacists largely envisaged a future for the service. The PAMS provided pharmacists an opportunity to become involved in an

  6. Experiences of community pharmacists involved in the delivery of a specialist asthma service in Australia

    Directory of Open Access Journals (Sweden)

    Emmerton Lynne M

    2012-06-01

    Full Text Available Abstract Background The role of community pharmacists in disease state management has been mooted for some years. Despite a number of trials of disease state management services, there is scant literature into the engagement of, and with, pharmacists in such trials. This paper reports pharmacists’ feedback as providers of a Pharmacy Asthma Management Service (PAMS, a trial coordinated across four academic research centres in Australia in 2009. We also propose recommendations for optimal involvement of pharmacists in academic research. Methods Feedback about the pharmacists’ experiences was sought via their participation in either a focus group or telephone interview (for those unable to attend their scheduled focus group at one of three time points. A semi-structured interview guide focused discussion on the pharmacists’ training to provide the asthma service, their interactions with health professionals and patients as per the service protocol, and the future for this type of service. Focus groups were facilitated by two researchers, and the individual interviews were shared between three researchers, with data transcribed verbatim and analysed manually. Results Of 93 pharmacists who provided the PAMS, 25 were involved in a focus group and seven via telephone interview. All pharmacists approached agreed to provide feedback. In general, the pharmacists engaged with both the service and research components, and embraced their roles as innovators in the trial of a new service. Some experienced challenges in the recruitment of patients into the service and the amount of research-related documentation, and collaborative patient-centred relationships with GPs require further attention. Specific service components, such as the spirometry, were well received by the pharmacists and their patients. Professional rewards included satisfaction from their enhanced practice, and pharmacists largely envisaged a future for the service. Conclusions The

  7. Parent Involvement in Meaningful Post-School Experiences for Young Adults with IDD and Pervasive Support Needs

    Science.gov (United States)

    Rossetti, Zachary; Lehr, Donna; Pelerin, Dana; Huang, Shuoxi; Lederer, Leslie

    2016-01-01

    Despite initiatives supporting young adults with intellectual and developmental disabilities (IDD) to engage in post-secondary education and integrated employment, those with more intensive support needs are not as easily involved in these post-school experiences. In an effort to learn from positive examples, we examined parent involvement in…

  8. Capgras syndrome: a review of the neurophysiological correlates and presenting clinical features in cases involving physical violence.

    Science.gov (United States)

    Bourget, Dominique; Whitehurst, Laurie

    2004-11-01

    Acts of violence have been frequently reported in cases of Capgras syndrome (CS), a misidentification syndrome characterized by the delusional belief that imposters have replaced people familiar to the individual. CS has been observed in many neuropsychiatric and organic disorders, and neuroimaging studies indicate an association between CS and right hemisphere abnormalities. However, CS has received limited attention from a forensic psychiatric perspective. We propose that elucidating demographic and clinical features noted in cases of violence secondary to CS may highlight important factors in the progression of CS to violence. We review the neurophysiological correlates and clinical factors observed in CS and present characteristics of a series of cases that demonstrate the potential of CS patients for severe physical violence toward the misidentified person. For patients with CS involving assault, we present and discuss commonly reported demographic and clinical features that may contribute to an increased risk for violence. An understanding of the presenting clinical features of CS resulting in aggressive acts may assist clinicians to assess the potential for violence in these patients.

  9. Correlation analysis of indicators of physical condition, health and physical fitness of soldiers involved in peacekeeping operations

    Directory of Open Access Journals (Sweden)

    S.S. Fedak

    2014-01-01

    Full Text Available Purpose: to identify the main physical qualities, which positively influence the physical state, health and military - professional career peacekeepers when performing tasks in different climatic conditions. Material : the study involved 98 military service under the contract the first age group (men. Analyzed contingent divided into groups according to climatic conditions of service: in the highlands - 37 person, in hot climates - 35 person, in towns and areas with limited space - 26 person. A correlation analysis between the results of running 100 meters, pulling, running 3 kilometre and indicators of the health and physical condition of the soldiers. Results : It was determined that the participation in peacekeeping missions in mountainous areas and in areas with a hot climate is the quality of the underlying physical endurance. With the participation in peacekeeping missions in populated areas and in areas with limited space - this is the strength and speed. Conclusions : on improving these physical qualities should focus during lessons in physical training of peacekeepers in the centers of immediate preparation for missions.

  10. First experience from in-core sensor validation based on correlation and neuro-fuzzy techniques

    International Nuclear Information System (INIS)

    Figedy, S.

    2011-01-01

    In this work new types of nuclear reactor in-core sensor validation methods are outlined. The first one is based on combination of correlation coefficients and mutual information indices, which reflect the correlation of signals in linear and nonlinear regions. The method may be supplemented by wavelet transform based signal features extraction and pattern recognition by artificial neural networks and also fuzzy logic based decision making. The second one is based on neuro-fuzzy modeling of residuals between experimental values and their theoretical counterparts obtained from the reactor core simulator calculations. The first experience with this approach is described and further improvements to enhance the outcome reliability are proposed (Author)

  11. Psychiatric morbidity and people's experience of and response to social problems involving rights.

    Science.gov (United States)

    Balmer, Nigel J; Pleasence, Pascoe; Buck, Alexy

    2010-11-01

    Psychiatric morbidity has been shown to be associated with the increased reporting of a range of social problems involving legal rights ('rights problems'). Using a validated measure of psychiatric morbidity, this paper explores the relationship between psychiatric morbidity and rights problems and discusses the implications for the delivery of health and legal services. New representative national survey data from the English and Welsh Civil and Social Justice Survey (CSJS) surveyed 3040 adults in 2007 to explore the relationship between GHQ-12 scores and the self reported incidence of and behaviour surrounding, rights problems. It was found that the prevalence of rights problems increased with psychiatric morbidity, as did the experience of multiple problems. It was also found the likelihood of inaction in the face of problems increased with psychiatric morbidity, while the likelihood of choosing to resolve problems without help decreased. Where advice was obtained, psychiatric morbidity was associated with a greater tendency to obtain a combination of 'legal' and 'general' support, rather than 'legal' advice alone. The results suggest that integrated and 'outreach' services are of particular importance to the effective support of those facing mental illness. © 2010 Blackwell Publishing Ltd.

  12. Experience, Adoption, and Technology: Exploring the Phenomenological Experiences of Faculty Involved in Online Teaching at One School of Public Health

    Science.gov (United States)

    Kidd, Terry; Davis, Trina; Larke, Patricia

    2016-01-01

    Using the Unified Theory of Acceptance and Use of Technology (UTAUT) and Dewey's Theory of Experience, this phenomenological study explored the experiences of faculty who engaged in online teaching at one school of public health. Findings revealed that the experiences of public health faculty, who engaged in online teaching, are similar and…

  13. Clinical experience does not correlate with the perceived need for cardiopulmonary resuscitation training.

    Science.gov (United States)

    Lunz, Dirk; Brandl, Anita; Lang, Klaus; Weiss, Berthold; Haneya, Assad; Pühler, Thomas; Graf, Bernhard M; Zausig, York A

    2013-02-01

    The efficiency of cardiopulmonary resuscitation (CPR) training is dependent upon different influencing factors, such as the presented concepts, the participants' willingness to learn, and the interval between training sessions. However, the optimal interval for refreshing CPR training is less clear. We evaluated the perceived need of simulator-based CPR training for nurses and correlated it with their clinical experience. The 60 invited nurses were trained in simulator-based CPR. Knowledge about adult advanced life support was evaluated using a questionnaire after training, and participants rated their desired individual frequency of simulator-based training as well as the value of the presented training using a six-point Likert scale. The same questions were asked again after 1 year. All participants agreed about the usefulness of this type of simulator-based training. The average number of correct answers about typical facts in adult advanced life support showed an almost bell-shaped distribution, with the highest point at 6-15 years of clinical experience and the lowest points at≤5 and≥21 years. The desired training-frequency need was inversely correlated with clinical experience. There is a high interest in CPR training among nursing staff. Self-assessment about the training-frequency need was inversely correlated with clinical experience. However, the average number of correct answers on resuscitation questions decreased with clinical experience. Therefore, the training effectiveness seems to be extremely dependent on clinical experience, and therefore, training experienced senior nurses might be more challenging than training novice nurses. Copyright © 2013 Elsevier Inc. All rights reserved.

  14. Effective Parental Involvement in Education: Experiences and Perceptions of Turkish Teachers from Private Schools

    Science.gov (United States)

    Gokturk, Soheyda; Dinckal, Selin

    2018-01-01

    Parental involvement has been associated with numerous student benefits. However, related literature reveals that neither parents nor teachers are content with the scope and depth of parental involvement in schools. This may be partly due to differential understandings that both sides have on the concept of parental involvement. In this study,…

  15. A Phenomenological Study of Parental Involvement and the Undergraduate College Student Experience

    Science.gov (United States)

    Garrison, David Michael

    2013-01-01

    Parents highly involved in the academic lives of their college-going children have become increasingly common and yet the effect of such involvement on students is poorly understood by student services administrators and faculty. The purpose of this study was to better define the phenomenon of parental involvement in college through an…

  16. Correlation, necessity, and sufficiency: Common errors in the scientific reasoning of undergraduate students for interpreting experiments.

    Science.gov (United States)

    Coleman, Aaron B; Lam, Diane P; Soowal, Lara N

    2015-01-01

    Gaining an understanding of how science works is central to an undergraduate education in biology and biochemistry. The reasoning required to design or interpret experiments that ask specific questions does not come naturally, and is an essential part of the science process skills that must be learned for an understanding of how scientists conduct research. Gaps in these reasoning skills make it difficult for students to become proficient in reading primary scientific literature. In this study, we assessed the ability of students in an upper-division biochemistry laboratory class to use the concepts of correlation, necessity, and sufficiency in interpreting experiments presented in a format and context that is similar to what they would encounter when reading a journal article. The students were assessed before and after completion of a laboratory module where necessary vs. sufficient reasoning was used to design and interpret experiments. The assessment identified two types of errors that were commonly committed by students when interpreting experimental data. When presented with an experiment that only establishes a correlation between a potential intermediate and a known effect, students frequently interpreted the intermediate as being sufficient (causative) for the effect. Also, when presented with an experiment that tests only necessity for an intermediate, they frequently made unsupported conclusions about sufficiency, and vice versa. Completion of the laboratory module and instruction in necessary vs. sufficient reasoning showed some promise for addressing these common errors. © 2015 The International Union of Biochemistry and Molecular Biology.

  17. Theoretical investigations of quantum correlations in NMR multiple-pulse spin-locking experiments

    Science.gov (United States)

    Gerasev, S. A.; Fedorova, A. V.; Fel'dman, E. B.; Kuznetsova, E. I.

    2018-04-01

    Quantum correlations are investigated theoretically in a two-spin system with the dipole-dipole interactions in the NMR multiple-pulse spin-locking experiments. We consider two schemes of the multiple-pulse spin-locking. The first scheme consists of π /2-pulses only and the delays between the pulses can differ. The second scheme contains φ-pulses (0Quantum discord is obtained for the first scheme of the multiple-pulse spin-locking experiment at different temperatures.

  18. Homonuclear long-range correlation spectra from HMBC experiments by covariance processing.

    Science.gov (United States)

    Schoefberger, Wolfgang; Smrecki, Vilko; Vikić-Topić, Drazen; Müller, Norbert

    2007-07-01

    We present a new application of covariance nuclear magnetic resonance processing based on 1H--13C-HMBC experiments which provides an effective way for establishing indirect 1H--1H and 13C--13C nuclear spin connectivity at natural isotope abundance. The method, which identifies correlated spin networks in terms of covariance between one-dimensional traces from a single decoupled HMBC experiment, derives 13C--13C as well as 1H--1H spin connectivity maps from the two-dimensional frequency domain heteronuclear long-range correlation data matrix. The potential and limitations of this novel covariance NMR application are demonstrated on two compounds: eugenyl-beta-D-glucopyranoside and an emodin-derivative. Copyright (c) 2007 John Wiley & Sons, Ltd.

  19. Correlates of domestic violence experience among recently-married women residing in slums in Pune, India.

    Science.gov (United States)

    Kalokhe, Ameeta S; Iyer, Sandhya R; Kolhe, Ambika R; Dhayarkar, Sampada; Paranjape, Anuradha; Del Rio, Carlos; Stephenson, Rob; Sahay, Seema

    2018-01-01

    The high risk of experiencing domestic violence (DV) among married women in India who reside in slum communities underscores the need for effective, evidence-based, and culturally-tailored primary prevention. To inform such DV primary prevention strategies for this population, we herein aimed to identify correlates of DV experience in early marriage. Utilizing a cross-sectional design, potential correlates of DV experience were explored among a geographically-clustered random sample of 100 recently-married women residing in slums in Pune, India. In multivariable regression, DV experience was associated with less educational attainment by the participant's spouse (standardized β = -0.281, p = 0.004), less satisfaction of the spouse's family with the maanpaan (wedding-related gifts provided by the bride's family) they received at the time of marriage (standardized β = -0.298, p<0.001), poorer conflict negotiation skills (standardized β = -0.308, p<0.001), and greater acknowledgement of DV occurrence in family and friends (standardized β = 0.436, p<0.001). These correlates suggest strategies that could be incorporated into future DV primary prevention interventions for this vulnerable population (i.e. promoting completion of formal education of boys alongside girls, mitigating causes of familial dowry harassment, improving conflict negotiation skills, and challenging norms surrounding DV).

  20. Perception of chemesthetic stimuli in groups who differ by food involvement and culinary experience.

    Science.gov (United States)

    Byrnes, Nadia; Loss, Christopher R; Hayes, John E

    2015-12-01

    In the English language, there is generally a limited lexicon when referring to the sensations elicited by chemesthetic stimuli like capsaicin, allyl isothiocyanate, and eugenol, the orally irritating compounds found in chiles, wasabi, and cloves, respectively. Elsewhere, experts and novices have been shown to use language differently, with experts using more precise language. Here, we compare perceptual maps and word usage across three cohorts: experts with formal culinary education, naïve individuals with high Food Involvement Scale (FIS) scores, and naïve individuals with low FIS scores. We hypothesized that increased experience with foods, whether through informal experiential learning or formal culinary education, would have a significant influence on the perceptual maps generated from a sorting task conducted with chemesthetic stimuli, as well as on language use in a descriptive follow-up task to this sorting task. The low- and highFIS non-expert cohorts generated significantly similar maps, though in other respects the highFIS cohort was an intermediate between the lowFIS and expert cohorts. The highFIS and expert cohorts generated more attributes but used language more idiosyncratically than the lowFIS group. Overall, the results from the expert group with formal culinary education differed from the two naïve cohorts both in the perceptual map generated using MDS as well as the mean number of attributes generated. Present data suggest that both formal education and informal experiential learning result in lexical development, but the level and type of learning can have a significant influence on language use and the approach to a sorting task.

  1. Improved Emergency Preparedness For Management Of The Food chain Via Stakeholder Involvement: Belgian and European Experience

    Energy Technology Data Exchange (ETDEWEB)

    Hardeman, Frank; Carle, Benny [SCK.CEN, the Belgian Nuclear Research Centre, Boeretang 200, 2400 Mol (Belgium); Turcanu, Catrinel [Universite Libre de Bruxelles, Av. F. Roosevelt 50, 1050 Brussels (Belgium); Vandecasteele, Christian [FANC, Federal Agency for Nuclear Control, Ravensteinstraat 36, 1000 Brussels (Belgium)

    2006-07-01

    Initiatives involving stakeholder engagement have gained increasing importance in sustainable decision making for many risk-related issues. This paper describes a Belgian experience within a European context related to food management options in the event of a radioactive contamination of the food chain. Under the auspices of the European Commission's 5. Framework Programme, the F.A.R.M.I.N.G. (F.A.R.M.I.N.G. 2000) project (co-ordinated by H.P.A.) a stakeholder network was established in a number of European countries, following a successful approach originally adopted in the UK. In a comparable approach, national working groups were thus established in Belgium, Finland, France and Greece in order to organise stakeholder panels and to discuss the outcomes of scientific and technical research related to management options for the food chain. The results of these panels were exchanged between participating Member States and on a wider international basis at the W.I.S.D.O.M.2. workshop in 2003. The F.A.R.M.I.N.G. project had many achievements and there were also several important lessons learned for Belgium (Vandecasteele et al., 2005): Firstly, many stakeholders showed a real interest in tackling problems relating to food chain contamination; Secondly, the Belgian agricultural system is very intensive and technically and economically optimised, making many of the options envisaged difficult to implement; thirdly, the applicability of management options is also limited by political and legal issues (e.g. competencies, environmental legislation), operational constraints (e.g. waste treatment, supplies of materials), societal and ethical aspects (e.g. milk disposal to sea, animal welfare), and economics (e.g. who pays the intervention cost?); fourthly, there is a now a greater awareness of these problems in both the food production sector and among the experts involved in emergency management; Fifthly, increased attention is now given in Belgium to the medium and

  2. Improved Emergency Preparedness For Management Of The Food chain Via Stakeholder Involvement: Belgian and European Experience

    International Nuclear Information System (INIS)

    Hardeman, Frank; Carle, Benny; Turcanu, Catrinel; Vandecasteele, Christian

    2006-01-01

    Initiatives involving stakeholder engagement have gained increasing importance in sustainable decision making for many risk-related issues. This paper describes a Belgian experience within a European context related to food management options in the event of a radioactive contamination of the food chain. Under the auspices of the European Commission's 5. Framework Programme, the F.A.R.M.I.N.G. (F.A.R.M.I.N.G. 2000) project (co-ordinated by H.P.A.) a stakeholder network was established in a number of European countries, following a successful approach originally adopted in the UK. In a comparable approach, national working groups were thus established in Belgium, Finland, France and Greece in order to organise stakeholder panels and to discuss the outcomes of scientific and technical research related to management options for the food chain. The results of these panels were exchanged between participating Member States and on a wider international basis at the W.I.S.D.O.M.2. workshop in 2003. The F.A.R.M.I.N.G. project had many achievements and there were also several important lessons learned for Belgium (Vandecasteele et al., 2005): Firstly, many stakeholders showed a real interest in tackling problems relating to food chain contamination; Secondly, the Belgian agricultural system is very intensive and technically and economically optimised, making many of the options envisaged difficult to implement; thirdly, the applicability of management options is also limited by political and legal issues (e.g. competencies, environmental legislation), operational constraints (e.g. waste treatment, supplies of materials), societal and ethical aspects (e.g. milk disposal to sea, animal welfare), and economics (e.g. who pays the intervention cost?); fourthly, there is a now a greater awareness of these problems in both the food production sector and among the experts involved in emergency management; Fifthly, increased attention is now given in Belgium to the medium and long

  3. Charge-dependent azimuthal correlations in pPb collisions with CMS experiment

    Science.gov (United States)

    Tu, Zhoudunming; CMS Collaboration

    2017-11-01

    Charge-dependent azimuthal correlations relative to the event plane in AA collisions have been suggested as providing evidence for the chiral magnetic effect (CME) caused by local strong parity violation. However, the observation of the CME remains inconclusive because of several possible sources of background correlations that may account for part or all of the observed signals. This talk will present the first application of three-particle, charge-dependent azimuthal correlation analysis in proton-nucleus collisions, using pPb data collected with the CMS experiment at the LHC at √{sNN} = 5.02 TeV. The differences found in comparing same and opposite sign correlations are studied as a function of event multiplicity and the pseudorapidity gap between two of the particles detected in the CMS tracker detector. After selecting events with comparable charge-particle multiplicities, the results for pPb collisions are found to be similar to those for PbPb collisions collected at the same collision energy. With a reduced magnetic field strength and a random field orientation in high multiplicity pPb events, the CME contribution to any charge separation signal is expected to be much smaller than found in peripheral PbPb events. These results pose a challenge for the interpretation of charge-dependent azimuthal correlations in heavy ion collisions in terms of the chiral magnetic effect.

  4. Correlations between nuclear data and integral slab experiments: the case of hafnium; Correlations entre donnees nucleaires et experiences integrales a plaques: le cas du hafnium

    Energy Technology Data Exchange (ETDEWEB)

    Palau, J.M

    1999-07-01

    The aim of this work was to evaluate how much integral slab experiments can both reduce discrepancies between experimental results and calculations, and improve the knowledge of hafnium isotopes neutronic parameters by an adapted sensitivity and uncertainty method. A statistical approach, based on the generalized least squares method and perturbation theory, has been incorporated into our calculation system in order to deduce microscopic cross-section adjustments from observed integral measurements on this particular 'mock-up' reactor.In this study it has been established that the correlations between integral parameters and hafnium capture cross-sections enable specific variations in the region of resolved resonances at the level of multigroup and punctual cross-sections recommended data (JEF-2.2 evaluation) to be highlighted. The use of determinist methods together with Monte Carlo- type simulations enabled a depth analysis of the modelling approximations to be carried out. Furthermore, the sensitivity coefficient validation technique employed leads to a reliable assessment of the quality of the new basic nuclear data. In this instance, the adjustments proposed for certain isotope {sup 177}Hf resonance parameters reduce, after error propagation, by 3 to 5 per cent the difference between experimental results and calculations related to this absorbent's efficiency. Beyond this particular application, the qualification methodology integrated in our calculation system should enable other basic sizing parameters to be treated (chemical / geometric data or other unexplored nuclear data) to make technological requirements less stringent. (author)

  5. Correlations between nuclear data and integral slab experiments: the case of hafnium; Correlations entre donnees nucleaires et experiences integrales a plaques: le cas du hafnium

    Energy Technology Data Exchange (ETDEWEB)

    Palau, J M

    1999-07-01

    The aim of this work was to evaluate how much integral slab experiments can both reduce discrepancies between experimental results and calculations, and improve the knowledge of hafnium isotopes neutronic parameters by an adapted sensitivity and uncertainty method. A statistical approach, based on the generalized least squares method and perturbation theory, has been incorporated into our calculation system in order to deduce microscopic cross-section adjustments from observed integral measurements on this particular 'mock-up' reactor.In this study it has been established that the correlations between integral parameters and hafnium capture cross-sections enable specific variations in the region of resolved resonances at the level of multigroup and punctual cross-sections recommended data (JEF-2.2 evaluation) to be highlighted. The use of determinist methods together with Monte Carlo- type simulations enabled a depth analysis of the modelling approximations to be carried out. Furthermore, the sensitivity coefficient validation technique employed leads to a reliable assessment of the quality of the new basic nuclear data. In this instance, the adjustments proposed for certain isotope {sup 177}Hf resonance parameters reduce, after error propagation, by 3 to 5 per cent the difference between experimental results and calculations related to this absorbent's efficiency. Beyond this particular application, the qualification methodology integrated in our calculation system should enable other basic sizing parameters to be treated (chemical / geometric data or other unexplored nuclear data) to make technological requirements less stringent. (author)

  6. Correlations between nuclear data and results of integral slab experiments. Case of hafnium; Correlations entre donnees nucleaires et experiences integrales a plaques: le cas du hafnium

    Energy Technology Data Exchange (ETDEWEB)

    Palau, J M

    1997-10-22

    The aim of this thesis was to evaluate how much integral slab experiments can both reduce discrepancies between experimental results and calculations, and improve the knowledge of hafnium isotopes neutronic parameters by an adapted sensitivity and uncertainty method. A statistical approach, based on the generalized least squares method and perturbation theory, has been incorporated into our calculation system in order to deduce microscopic cross-section adjustments from observed integral measurements on this particular `mock-up` reactor. In this study it has been established that the correlations between integral parameters and hafnium capture cross-sections enable specific variations in the region of resolved resonances at the level of multigroup and punctual cross-sections recommended data (JEF-2.2 evaluation) to be highlighted. The use of determinist methods (APOLLO2 code) together with Monte Carlo- type simulations (TRIPOLI4 code) enabled a depth analysis of the modelling approximations to be carried out. Furthermore, the sensitivity coefficient validation technique employed leads to a reliable assessment of the quality of the new basic nuclear data. In this instance, the adjustments proposed for certain isotope {sup 177}Hf resonance parameters reduce, after error propagation, by 3 to 5 per cent the difference between experimental results and calculations related to this absorbent`s efficiency. Beyond this particular application, the qualification methodology integrated in our calculation system should enable other basic sizing parameters to be treated (chemical / geometric data or other unexplored nuclear data) to make technological requirements less stringent. (author) 128 refs.

  7. Solving local problems through local involvement? Experiences from Danish Urban Regeneration

    DEFF Research Database (Denmark)

    Jensen, Jesper Ole

    -down approaches or massive public subsidies, the public regeneration schemes from the last decade have increasingly emphasized the need for involving local actors in the urban regeneration e.g. through partnerships, network building, involvement and participation of local actors and institutions, and financially...... agenda, and what can be learned from the development so far. Although ‘local involvement’ is a commonly used term in various urban regeneration programs, it can have many different meanings and implications. Therefore, the paper will discuss local involvement in the urban regeneration based on four...

  8. Charge-dependent azimuthal correlations in pPb collisions with CMS experiment

    CERN Document Server

    Tu, Zhoudunming

    2017-01-01

    Charge-dependent azimuthal correlations relative to the event plane in AA collisions have been suggested as providing evidence for the chiral magnetic effect (CME) caused by local strong parity violation. However, the observation of the CME remains inconclusive because of several possible sources of background correlations that may account for part or all of the observed signals. This talk will present the first application of three-particle, charge-dependent azimuthal correlation analysis in proton-nucleus collisions, using pPb data collected with the CMS experiment at the LHC at $\\sqrt{s_{NN}}$ = 5.02 TeV. The differences found in comparing same and opposite sign correlations are studied as a function of event multiplicity and the pseudorapidity gap between two of the particles detected in the CMS tracker detector. After selecting events with comparable charge-particle multiplicities, the results for pPb collisions are found to be similar to those for PbPb collisions collected at the same collision energy. ...

  9. The physics of flocking: Correlation as a compass from experiments to theory

    Science.gov (United States)

    Cavagna, Andrea; Giardina, Irene; Grigera, Tomás S.

    2018-01-01

    Collective behavior in biological systems is a complex topic, to say the least. It runs wildly across scales in both space and time, involving taxonomically vastly different organisms, from bacteria and cell clusters, to insect swarms and up to vertebrate groups. It entails concepts as diverse as coordination, emergence, interaction, information, cooperation, decision-making, and synchronization. Amid this jumble, however, we cannot help noting many similarities between collective behavior in biological systems and collective behavior in statistical physics, even though none of these organisms remotely looks like an Ising spin. Such similarities, though somewhat qualitative, are startling, and regard mostly the emergence of global dynamical patterns qualitatively different from individual behavior, and the development of system-level order from local interactions. It is therefore tempting to describe collective behavior in biology within the conceptual framework of statistical physics, in the hope to extend to this new fascinating field at least part of the great predictive power of theoretical physics. In this review we propose that the conceptual cornerstone of this ambitious program be that of correlation. To illustrate this idea we address the case of collective behavior in bird flocks. Two key threads emerge, as two sides of one single story: the presence of scale-free correlations and the dynamical mechanism of information transfer. We discuss first static correlations in starling flocks, in particular the experimental finding of their scale-free nature, the formulation of models that account for this fact using maximum entropy, and the relation of scale-free correlations to information transfer. This is followed by a dynamic treatment of information propagation (propagation of turns across a flock), starting with a discussion of experimental results and following with possible theoretical explanations of those, which require the addition of behavioral

  10. Involvement of Consumer Groups in Tobacco Control: Russia and Belarus Experience

    Directory of Open Access Journals (Sweden)

    Dmitry Yanin

    2017-05-01

    5. Cooperation of consumer organizations from Russia (KONFOP and Belarus (Belarus Consumer Society, launched to promote best Tobacco Control practices, according to FCTC provisions, is a success story of involvement of consumer groups in Tobacco Control.

  11. Plasma heating by relativistic electron beams: correlations between experiment and theory

    International Nuclear Information System (INIS)

    Thode, L.E.; Godfrey, B.B.

    1975-01-01

    The streaming instability is the primary heating mechanism in most, if not all, experiments in which the beam is injected into partially or fully ionized gas. In plasma heating experiments, the relativistic beam must traverse an anode foil before interacting with the plasma. The linear theory for such a scattered beam is discussed, including a criterion for the onset of the kinetic interaction. A nonlinear model of the two-stream instability for a scattered beam is developed. Using this model, data from ten experiments are unfolded to obtain the following correlations: (i) for a fixed anode foil, the dependence of the plasma heating on the beam-to-plasma density ratio is due to anode foil scattering, (ii) for a fixed beam-to-plasma density ratio, the predicted change in the magnitude of plasma heating as a function of the anode foil is in agreement with experiment, and (iii) the plasma heating tentatively appears to be proportional to the beam kinetic energy density and beam pulse length. For a fixed anode foil, theory also predicts that the energy deposition is improved by increasing the beam electron energy γmc 2 . Presently, no experiment has been performed to confirm this aspect of the theory

  12. Involving the public in epidemiological public health research: a qualitative study of public and stakeholder involvement in evaluation of a population-wide natural policy experiment.

    Science.gov (United States)

    Anderson de Cuevas, Rachel; Nylén, Lotta; Burström, Bo; Whitehead, Margaret

    2018-04-20

    Public involvement in research is considered good practice by European funders; however, evidence of its research impact is sparse, particularly in relation to large-scale epidemiological research. To explore what difference public and stakeholder involvement made to the interpretation of findings from an evaluation of a natural policy experiment to influence the wider social determinants of health: 'Flexicurity'. Stockholm County, Sweden. Members of the public from different occupational groups represented by blue-collar and white-collar trade union representatives. Also, members of three stakeholder groups: the Swedish national employment agency; an employers' association and politicians sitting on a national labour market committee. Total: 17 participants. Qualitative study of process and outcomes of public and stakeholder participation in four focused workshops on the interpretation of initial findings from the flexicurity evaluation. New insights from participants benefiting the interpretation of our research findings or conceptualisation of future research. Participants sensed more drastic and nuanced change in the Swedish welfare system over recent decades than was evident from our literature reviews and policy analysis. They also elaborated hidden developments in the Swedish labour market that were increasingly leading to 'insiders' and 'outsiders', with differing experiences and consequences for financial and job security. Their explanation of the differential effects of the various collective agreements for different occupational groups was new and raised further potential research questions. Their first-hand experience provided new insights into how changes to the social protection system were contributing to the increasing trends in poverty among unemployed people with limiting long-standing illness. The politicians provided further reasoning behind some of the policy changes and their intended and unintended consequences. These insights fed into

  13. Contribution to the study of elementary particles in experiments involving accelerators

    International Nuclear Information System (INIS)

    Baldisseri, A.

    2006-05-01

    This document reviews the theoretical, experimental and technical achievements of the author since the beginning of his scientific career. Works in 5 fields have been highlighted: 1) rare decays of the η meson, 2) neutrino oscillations in NOMAD experiment, 3) quark and gluon plasma, 4) the PHENIX experiment at RHIC, and 5) the ALICE experiment in LHC. The PHENIX experiment was dedicated to the accurate measuring of photons and dileptons (particularly J/Ψ, Ψ' resonances) produced in heavy ion collisions. The ALICE experiment is devoted to the study of the quark gluon plasma. Its detector must be able to detect charged particles with a broad range of transverse momenta (from 100 MeV/c to 100 GeV/c). This document presented before an academic board will allow his author to manage research works and particularly to tutor thesis students

  14. Sequential backbone assignment based on dipolar amide-to-amide correlation experiments

    Energy Technology Data Exchange (ETDEWEB)

    Xiang, ShengQi; Grohe, Kristof; Rovó, Petra; Vasa, Suresh Kumar; Giller, Karin; Becker, Stefan; Linser, Rasmus, E-mail: rali@nmr.mpibpc.mpg.de [Max Planck Institute for Biophysical Chemistry, Department for NMR-Based Structural Biology (Germany)

    2015-07-15

    Proton detection in solid-state NMR has seen a tremendous increase in popularity in the last years. New experimental techniques allow to exploit protons as an additional source of information on structure, dynamics, and protein interactions with their surroundings. In addition, sensitivity is mostly improved and ambiguity in assignment experiments reduced. We show here that, in the solid state, sequential amide-to-amide correlations turn out to be an excellent, complementary way to exploit amide shifts for unambiguous backbone assignment. For a general assessment, we compare amide-to-amide experiments with the more common {sup 13}C-shift-based methods. Exploiting efficient CP magnetization transfers rather than less efficient INEPT periods, our results suggest that the approach is very feasible for solid-state NMR.

  15. Sequential backbone assignment based on dipolar amide-to-amide correlation experiments

    International Nuclear Information System (INIS)

    Xiang, ShengQi; Grohe, Kristof; Rovó, Petra; Vasa, Suresh Kumar; Giller, Karin; Becker, Stefan; Linser, Rasmus

    2015-01-01

    Proton detection in solid-state NMR has seen a tremendous increase in popularity in the last years. New experimental techniques allow to exploit protons as an additional source of information on structure, dynamics, and protein interactions with their surroundings. In addition, sensitivity is mostly improved and ambiguity in assignment experiments reduced. We show here that, in the solid state, sequential amide-to-amide correlations turn out to be an excellent, complementary way to exploit amide shifts for unambiguous backbone assignment. For a general assessment, we compare amide-to-amide experiments with the more common 13 C-shift-based methods. Exploiting efficient CP magnetization transfers rather than less efficient INEPT periods, our results suggest that the approach is very feasible for solid-state NMR

  16. A retrospective analysis of compact fluorescent lamp experience curves and their correlations to deployment programs

    International Nuclear Information System (INIS)

    Smith, Sarah Josephine; Wei, Max; Sohn, Michael D.

    2016-01-01

    Experience curves are useful for understanding technology development and can aid in the design and analysis of market transformation programs. Here, we employ a novel approach to create experience curves, to examine both global and North American compact fluorescent lamp (CFL) data for the years 1990–2007. We move away from the prevailing method of fitting a single, constant, exponential curve to data and instead search for break points where changes in the learning rate may have occurred. Our analysis suggests a learning rate of approximately 21% for the period of 1990–1997, and 51% and 79% in global and North American datasets, respectively, after 1998. We use price data for this analysis; therefore our learning rates encompass developments beyond typical “learning by doing”, including supply chain impacts such as market competition. We examine correlations between North American learning rates and the initiation of new programs, abrupt technological advances, and economic and political events, and find an increased learning rate associated with design advancements and federal standards programs. Our findings support the use of segmented experience curves for retrospective and prospective technology analysis, and may imply that investments in technology programs have contributed to an increase of the CFL learning rate. - Highlights: • We develop a segmented regression technique to estimate historical CFL learning curves. • CFL experience curves do not have a constant learning rate. • CFLs exhibited a learning rate of approximately 21% from 1990 to 1997. • The CFL learning rate significantly increased after 1998. • Increased CFL learning rate is correlated to technology deployment programs.

  17. Correlates of male involvement in maternal and newborn health: a cross-sectional study of men in a peri-urban region of Myanmar.

    Science.gov (United States)

    Ampt, Frances; Mon, Myo Myo; Than, Kyu Kyu; Khin, May May; Agius, Paul A; Morgan, Christopher; Davis, Jessica; Luchters, Stanley

    2015-05-27

    Evidence suggests that increasing male involvement in maternal and newborn health (MNH) may improve MNH outcomes. However, male involvement is difficult to measure, and further research is necessary to understand the barriers and enablers for men to engage in MNH, and to define target groups for interventions. Using data from a peri-urban township in Myanmar, this study aimed to construct appropriate indicators of male involvement in MNH, and assess sociodemographic, knowledge and attitude correlates of involvement. A cross-sectional study of married men with one or more children aged up to one year was conducted in 2012. Structured questionnaires measured participants' involvement in MNH, and their sociodemographic characteristics, knowledge and attitudes. An ordinal measure of male involvement was constructed describing the subject's participation across five areas of MNH, giving a score of 1-4. Proportional-odds regression models were developed to determine correlates of male involvement. A total of 210 men participated in the survey, of which 203 provided complete data. Most men reported involvement level scores of either 2 or 3 (64 %), with 13 % reporting the highest level (score of 4). Involvement in MNH was positively associated with wives' level of education (AOR = 3.4; 95 % CI: 1.9-6.2; p MNH (AOR = 1.2; 95 % CI: 1.1-1.3; p MNH. The composite index proved a useful summary measure of involvement; however, it may have masked differential determinants of the summed indicators. There is a need for greater understanding of the influence of gender attitudes on male involvement in Myanmar and more robust indicators that capture these gender dynamics for use both in Myanmar and globally.

  18. Pump-probe experiments in atoms involving laser and synchrotron radiation: an overview

    International Nuclear Information System (INIS)

    Wuilleumier, F J; Meyer, M

    2006-01-01

    The combined use of laser and synchrotron radiations for atomic photoionization studies started in the early 1980s. The strong potential of these pump-probe experiments to gain information on excited atomic states is illustrated through some exemplary studies. The first series of experiments carried out with the early synchrotron sources, from 1960 to about 1995, are reviewed, including photoionization of unpolarized and polarized excited atoms, and time-resolved laser-synchrotron studies. With the most advanced generation of synchrotron sources, a whole new class of pump-probe experiments benefiting from the high brightness of the new synchrotron beams has been developed since 1996. A detailed review of these studies as well as possible future applications of pump-probe experiments using third generation synchrotron sources and free electron lasers is presented. (topical review)

  19. Experience of Early Childhood Caries May Positively Correlate with Psychomotor Development.

    Science.gov (United States)

    Liang, Chen-Yi; Liu, Yen-Chun; Shieh, Tien-Yu; Lin, Jia-Rong; Tseng, Yi-Chun; Teng, Andy Yen-Tung

    2015-01-01

    To examine the as yet unknown relationship between dental caries and the child's psychomotor development. A cross-sectional study was designed by screening the kindergartens from urban areas of two cities in southern Taiwan. Besides the personal, demographic and dietary information, the common measures for caries (dmft) and the amended comprehensive scales (CCDI) for psychomotor development were used to assess their relationship(s). A power analysis showed that 334 subjects would be required. One-way ANOVA vs multiple linear regression analysis were used to compare the differences of variables between gender, age and dmft scales, vs the relationship among all variables tested, respectively. A total of 433 children completed the study. The results demonstrated that there was a positive relationship between higher (i.e. dmft≥4 and 5) but not lower or extremely high caries experience and aspects of psychomotor development (i.e. personal-social and expressive language) in children aged 4 to 6 years. The present results are important for paediatric dentists, as they suggest a positive correlation between caries experience (dmft 3 to 6) and psychomotor development in pre-school children and that such a correlation may occur more significantly as an attribute of the most affected teeth (incisors and molars) during the critical stage of personal-social and expressive language development (speech-communication).

  20. NRC Information No. 87-24: Operational experience involving losses of electrical inverters

    International Nuclear Information System (INIS)

    Rossi, C.E.

    1992-01-01

    The NRC case study report identified three potential failure mechanisms for inverters. One of these involves relatively high ambient temperature and/or humidity within inverter enclosures. This condition appears to result in accelerated aging of components that form a part of the inverter circuitry causing a significant reduction in component life expectancy and inverter loss. Another mechanism for inverter failure involves the electrical interconnecting and physical arrangements for the inverter circuitry components. In some installations, these arrangements are such that when certain components fail, other components also may fail or degrade. The third failure mechanism involves voltage spikes and perturbations. Many of the electrical loads in a plant have inductive characteristics. During plant operations that involve energizing and deenergizing these loads, voltage spikes and perturbations are generated. The solid-state devices in the inverter circuitry are sensitive to these voltage spikes, and this has resulted in component failure, blown fuses, and inverter losses. Additionally, secondary voltage perturbations caused by lighting strikes or switching surges can have an adverse effect on inverter operation

  1. The Vocational Goals and Career Development of Criminally Involved Youth: Experiences That Help and Hinder

    Science.gov (United States)

    Bartlett, Jennifer; Domene, José F.

    2015-01-01

    Little is known about the career development of youth with a history of criminal activity and the factors that influence their career development. The ability to secure employment is important in predicting successful outcomes for this population, but unfortunately youth who have been involved in crime are likely to face a myriad of obstacles to…

  2. On the relationship between convex bodies related to correlation experiments with dichotomic observables

    Energy Technology Data Exchange (ETDEWEB)

    Avis, David [School of Computer Science, McGill University, 3480 University, Montreal, Quebec, H3A 2A7 (Canada); Imai, Hiroshi [Department of Computer Science, Graduate School of Information Science and Technology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Ito, Tsuyoshi [Department of Computer Science, Graduate School of Information Science and Technology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2006-09-08

    In this paper we explore further the connections between convex bodies related to quantum correlation experiments with dichotomic variables and related bodies studied in combinatorial optimization, especially cut polyhedra. Such a relationship was established in Avis et al (2005 J. Phys. A: Math. Gen. 38 10971-87) with respect to Bell inequalities. We show that several well-known bodies related to cut polyhedra are equivalent to bodies such as those defined by Tsirelson (1993 Hadronic J. Suppl. 8 329-45) to represent hidden deterministic behaviours, quantum behaviours and no-signalling behaviours. Among other things, our results allow a unique representation of these bodies, give a necessary condition for vertices of the no-signalling polytope, and give a method for bounding the quantum violation of Bell inequalities by means of a body that contains the set of quantum behaviours. Optimization over this latter body may be performed efficiently by semidefinite programming. In the second part of the paper we apply these results to the study of classical correlation functions. We provide a complete list of tight inequalities for the two party case with (m, n) dichotomic observables when m = 4, n = 4 and when min{l_brace}m, n{r_brace} {<=} 3, and give a new general family of correlation inequalities.

  3. The Depressive Experiences Questionnaire: validity and psychological correlates in a clinical sample.

    Science.gov (United States)

    Riley, W T; McCranie, E W

    1990-01-01

    This study sought to compare the original and revised scoring systems of the Depressive Experiences Questionnaire (DEQ) and to assess the construct validity of the Dependent and Self-Critical subscales of the DEQ in a clinically depressed sample. Subjects were 103 depressed inpatients who completed the DEQ, the Beck Depression Inventory (BDI), the Hopelessness Scale, the Automatic Thoughts Questionnaire (ATQ), the Rathus Assertiveness Schedule (RAS), and the Minnesota Multiphasic Personality Inventory (MMPI). The original and revised scoring systems of the DEQ evidenced good concurrent validity for each factor scale, but the revised system did not sufficiently discriminate dependent and self-critical dimensions. Using the original scoring system, self-criticism was significantly and positively related to severity of depression, whereas dependency was not, particularly for males. Factor analysis of the DEQ scales and the other scales used in this study supported the dependent and self-critical dimensions. For men, the correlation of the DEQ with the MMPI scales indicated that self-criticism was associated with psychotic symptoms, hostility/conflict, and a distress/exaggerated response set, whereas dependency did not correlate significantly with any MMPI scales. Females, however, did not exhibit a differential pattern of correlations between either the Dependency or the Self-Criticism scales and the MMPI. These findings suggest possible gender differences in the clinical characteristics of male and female dependent and self-critical depressive subtypes.

  4. Evaluation of Stomach Involvement of Non-Hodgkin’s Lymphoma: Single Center Experience

    Directory of Open Access Journals (Sweden)

    Mehmet Sevki Uyanik

    2015-06-01

    Full Text Available Introduction: Gastrointestinal tract is the most common site of involvement in non-Hodgkin’s lymphomas. Appropriate treatment regiments were not defined because of rare involvement. In the present study we aimed to evaluate treatment response of non-Hodgkin’s lymphoma patients with stomach involvement.    Methodology: 26 patients with stomach involvement were retrospectively analyzed between 01/01/1998 and 01/06/2014. Descriptive statistic was performed to analyze data.Results: 20 of the patients (76.9% were composed of primary stomach non-Hodgkin lymphoma, 6 of the patients (23.1% were composed of patients secondary involvement of the advanced stage disease. All of the patients were subtypes of B cell lymphoma. 3 of the patients (11.5% was indolent, 22 of the patients (84.6% was aggressive, and 1 of them (3.8% was very aggressive. Diffuse large B cell lymphoma was 72.9%; Maltoma was 8.7%, and Mantle cell lymphoma was %3.8. Complete response was achieved at 10 patients, partial response was achieved in 1 patient, and 7 patients were failed to response the treatment. Treatment response, and overall survival of low grade and high grade patients, both according to Ann-Arbor and Lugano classification systems were similar. Patients with elevated sedimentation rate had significant lower survival than patients with normal sedimentation rate (p=0.027.Discussion: Together with the data from recent studies, aggressive treatment approach without organ preservation should not be performed on patients without higher inflammatory response and early stage presentation. Sedimentation rate might help to clinicians for the treatment of choice. 

  5. The correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: initial clinical experience

    International Nuclear Information System (INIS)

    Halter, Ryan J; Zhou, Tian; Meaney, Paul M; Hartov, Alex; Barth, Richard J Jr; Rosenkranz, Kari M; Wells, Wendy A; Kogel, Christine A; Borsic, Andrea; Rizzo, Elizabeth J; Paulsen, Keith D

    2009-01-01

    Electromagnetic (EM) breast imaging provides low-cost, safe and potentially a more specific modality for cancer detection than conventional imaging systems. A primary difficulty in validating these EM imaging modalities is that the true dielectric property values of the particular breast being imaged are not readily available on an individual subject basis. Here, we describe our initial experience in seeking to correlate tomographic EM imaging studies with discrete point spectroscopy measurements of the dielectric properties of breast tissue. The protocol we have developed involves measurement of in vivo tissue properties during partial and full mastectomy procedures in the operating room (OR) followed by ex vivo tissue property recordings in the same locations in the excised tissue specimens in the pathology laboratory immediately after resection. We have successfully applied all of the elements of this validation protocol in a series of six women with cancer diagnoses. Conductivity and permittivity gauged from ex vivo samples over the frequency range 100 Hz–8.5 GHz are found to be similar to those reported in the literature. A decrease in both conductivity and permittivity is observed when these properties are gauged from ex vivo samples instead of in vivo. We present these results in addition to a case study demonstrating how discrete point spectroscopy measurements of the tissue can be correlated and used to validate EM imaging studies

  6. Pair natural orbital and canonical coupled cluster reaction enthalpies involving light to heavy alkali and alkaline earth metals: the importance of sub-valence correlation.

    Science.gov (United States)

    Minenkov, Yury; Bistoni, Giovanni; Riplinger, Christoph; Auer, Alexander A; Neese, Frank; Cavallo, Luigi

    2017-04-05

    In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes of Li, Be, Na, Mg, Ca, Sr, Ba and Pb(ii). Two strategies were investigated: in the former, only valence electrons were included in the correlation treatment, giving rise to the computationally very efficient FC (frozen core) approach; in the latter, all non-ECP electrons were included in the correlation treatment, giving rise to the AE (all electron) approach. Apart from reactions involving Li and Be, the FC approach resulted in non-homogeneous performance. The FC approach leads to very small errors (correlation effects. These large errors are reduced to a few kcal mol -1 if the AE approach is used or the sub-valence orbitals of metals are included in the correlation treatment. On the technical side, the CCSD(T) and DLPNO-CCSD(T) results differ by a fraction of kcal mol -1 , indicating the latter method as the perfect choice when the CPU efficiency is essential. For completely black-box applications, as requested in catalysis or thermochemical calculations, we recommend the DLPNO-CCSD(T) method with all electrons that are not covered by effective core potentials included in the correlation treatment and correlation-consistent polarized core valence basis sets of cc-pwCVQZ(-PP) quality.

  7. Mirroring the self: testing neurophysiological correlates of disturbed self-experience in schizophrenia spectrum.

    Science.gov (United States)

    Sestito, Mariateresa; Raballo, Andrea; Umiltà, Maria Alessandra; Leuci, Emanuela; Tonna, Matteo; Fortunati, Renata; De Paola, Giancarlo; Amore, Mario; Maggini, Carlo; Gallese, Vittorio

    2015-01-01

    Self-disorders (SDs) have been described as a core schizophrenia spectrum vulnerability phenotype, both in classic and contemporary psychopathological literature. However, such a core phenotype has not yet been investigated adopting a trans-domain approach that combines the phenomenological and the neurophysiological levels of analysis. The aim of this study is to investigate the relation between SDs and subtle, schizophrenia-specific impairments of emotional resonance that are supposed to reflect abnormalities in the mirror neurons mechanism. Specifically, we tested whether electromyographic response to emotional stimuli (i.e. a proxy for subtle changes in facial mimicry and related motor resonance mechanisms) would predict the occurrence of anomalous subjective experiences (i.e. SDs). Eighteen schizophrenia spectrum (SzSp) patients underwent a comprehensive psychopathological examination and were contextually tested with a multimodal paradigm, recording facial electromyographic activity of muscles in response to positive and negative emotional stimuli. Experiential anomalies were explored with the Bonn Scale for the Assessment of Basic Symptoms (BSABS) and then condensed into rational subscales mapping SzSp anomalous self-experiences. SzSp patients showed an imbalance in emotional motor resonance with a selective bias toward negative stimuli, as well as a multisensory integration impairment. Multiple regression analysis showed that electromyographic facial reactions in response to negative stimuli presented in auditory modality specifically and strongly correlated with SD subscore. The study confirms the potential of SDs as target phenotype for neurobiological research and encourages research into disturbed motor/emotional resonance as possible body-level correlate of disturbed subjective experiences in SzSp.

  8. CT features of peritoneal and mesenteric involvement in pediatric malignancies. Experience from thirteen cases

    International Nuclear Information System (INIS)

    Grenier, N.; Filiatrault, D.; Garel, L.; Dube, J.; Paille, P.; Grenier, N.

    1986-01-01

    A retrospective study of all patients presenting with abdominal malignancies since November 1982 was undertaken in order to assess the CT features of peritoneal and mesenteric involvement in childhood. Thirteen cases, including 4 cases of malignant lymphomas, 1 case of Hodgkin's disease, 5 cases of adrenal tumors and 3 cases of ovarian tumors, were selected. Providing a good technique, CT appears as the best imaging modality of the mesentery. CT is also reliable in showing peritoneal implants, even without ascites. A high quality vascular opacification is needed in order to recognize the involvement of the lesser omentum (6/13 cases in our series). Precise knowledge of the intra-abdominal extension of the primary neoplasm has a definite impact upon the surgical indications and therefore upon the prognosis [fr

  9. Multiple myeloma and central nervous system involvement: experience of a Brazilian center.

    Science.gov (United States)

    Dias, Ana Luiza Miranda Silva; Higashi, Fabiana; Peres, Ana Lúcia M; Cury, Pricilla; Crusoé, Edvan de Queiroz; Hungria, Vânia Tietsche de Moraes

    The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse. This retrospective cohort study reviewed data from medical records of patients followed up at the Gammopathy Outpatient Clinic of Santa Casa de Misericórdia de São Paulo from January 2008 to December 2016. Twenty patients were included, with a median follow-up of 33.5 months after central nervous system infiltration. The prevalence was 7%. The median age at diagnosis of multiple myeloma was 56.1 years, with 70% of participants being female. Sixteen patients had central nervous system infiltration at diagnosis of multiple myeloma. Seventeen patients had exclusive osteodural lesions and three had infiltrations of the leptomeninge, of which one had exclusive involvement and two had associated osteodural lesions. The median overall survival was 40.3 months after central nervous system involvement. The median overall survival in the group with central nervous system infiltration at relapse was 7.4 months. The patients with leptomeningeal involvement had a median overall survival of 5.8 months. Central nervous system infiltration is a rare condition, but it should be considered as a possibility in patients with multiple myeloma and neurological symptoms. The best treatment regimen for this condition remains unknown and, in most cases, the prognosis is unfavorable. Copyright © 2017. Published by Elsevier Editora Ltda.

  10. Multiple myeloma and central nervous system involvement: experience of a Brazilian center

    Directory of Open Access Journals (Sweden)

    Ana Luiza Miranda Silva Dias

    2018-01-01

    Full Text Available Introduction: The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse. Methods: This retrospective cohort study reviewed data from medical records of patients followed up at the Gammopathy Outpatient Clinic of Santa Casa de Misericórdia de São Paulo from January 2008 to December 2016. Results: Twenty patients were included, with a median follow-up of 33.5 months after central nervous system infiltration. The prevalence was 7%. The median age at diagnosis of multiple myeloma was 56.1 years, with 70% of participants being female. Sixteen patients had central nervous system infiltration at diagnosis of multiple myeloma. Seventeen patients had exclusive osteodural lesions and three had infiltrations of the leptomeninge, of which one had exclusive involvement and two had associated osteodural lesions. The median overall survival was 40.3 months after central nervous system involvement. The median overall survival in the group with central nervous system infiltration at relapse was 7.4 months. The patients with leptomeningeal involvement had a median overall survival of 5.8 months. Conclusion: Central nervous system infiltration is a rare condition, but it should be considered as a possibility in patients with multiple myeloma and neurological symptoms. The best treatment regimen for this condition remains unknown and, in most cases, the prognosis is unfavorable. Keywords: Central nervous system, Multiple myeloma, Radiotherapy, Chemotherapy, Prognosis

  11. The neural correlates of reciprocity are sensitive to prior experience of reciprocity.

    Science.gov (United States)

    Cáceda, Ricardo; Prendes-Alvarez, Stefania; Hsu, Jung-Jiin; Tripathi, Shanti P; Kilts, Clint D; James, G Andrew

    2017-08-14

    Reciprocity is central to human relationships and is strongly influenced by multiple factors including the nature of social exchanges and their attendant emotional reactions. Despite recent advances in the field, the neural processes involved in this modulation of reciprocal behavior by ongoing social interaction are poorly understood. We hypothesized that activity within a discrete set of neural networks including a putative moral cognitive neural network is associated with reciprocity behavior. Nineteen healthy adults underwent functional magnetic resonance imaging scanning while playing the trustee role in the Trust Game. Personality traits and moral development were assessed. Independent component analysis was used to identify task-related functional brain networks and assess their relationship to behavior. The saliency network (insula and anterior cingulate) was positively correlated with reciprocity behavior. A consistent array of brain regions supports the engagement of emotional, self-referential and planning processes during social reciprocity behavior. Published by Elsevier B.V.

  12. Australian Academic Librarians’ Experience of Evidence Based Practice Involves Empowering, Intuiting, Affirming, Connecting, Noticing, and Impacting

    Directory of Open Access Journals (Sweden)

    Joanne Marie Muellenbach

    2017-12-01

    Full Text Available A Review of: Miller, F., Partridge, H., Bruce, C., Yates, C., & Howlett, A. (2017. How academic librarians experience evidence-based practice: A grounded theory model. Library & Information Science Research, 39(2, 124-130. http://dx.doi.org/10.1016/j.lisr.2017.04.003 Abstract Objective – To explore and enhance the understanding of how Australian library and information science (LIS practitioners experience or understand evidence based practice (EBP within the context of their day-to-day professional work. Design – Constructivist grounded theory methodology. Setting – University libraries in Queensland, Australia. Subjects – 13 academic librarians. Methods – Researchers contacted academic librarians by email and invited each participant to take part in a 30-60 minute, semi-structured interview. They designed interview questions to allow participants to explain their process and experience of EBP. Main results – This study identified six categories of experience of EBP using a constructivist grounded theory analysis process. The categories are: Empowering; Intuiting; Affirming; Connecting; Noticing; and Impacting. Briefly, empowering includes being empowered, or empowering clients, colleagues, and institutions through improved practice or performance. Intuiting includes being intuitive, or using one’s own intuition, wisdom, and understanding, of colleagues and clients’ behaviours to solve problems and redesign services. Affirming includes being affirmed through sharing feedback and using affirmation to strengthen support for action. Connecting includes being connected, and building connections, with clients, colleagues, and institutions. Noticing includes being actively aware of, observing, and reflecting on clients, colleagues, and literature within and outside of one’s own university, and noticing patterns in data to inform decision-making. Impacting includes being impactful, or having a visible impact, on clients, colleagues

  13. Fiction feelings in Harry Potter: haemodynamic response in the mid-cingulate cortex correlates with immersive reading experience.

    Science.gov (United States)

    Hsu, Chun-Ting; Conrad, Markus; Jacobs, Arthur M

    2014-12-03

    Immersion in reading, described as a feeling of 'getting lost in a book', is a ubiquitous phenomenon widely appreciated by readers. However, it has been largely ignored in cognitive neuroscience. According to the fiction feeling hypothesis, narratives with emotional contents invite readers more to be empathic with the protagonists and thus engage the affective empathy network of the brain, the anterior insula and mid-cingulate cortex, than do stories with neutral contents. To test the hypothesis, we presented participants with text passages from the Harry Potter series in a functional MRI experiment and collected post-hoc immersion ratings, comparing the neural correlates of passage mean immersion ratings when reading fear-inducing versus neutral contents. Results for the conjunction contrast of baseline brain activity of reading irrespective of emotional content against baseline were in line with previous studies on text comprehension. In line with the fiction feeling hypothesis, immersion ratings were significantly higher for fear-inducing than for neutral passages, and activity in the mid-cingulate cortex correlated more strongly with immersion ratings of fear-inducing than of neutral passages. Descriptions of protagonists' pain or personal distress featured in the fear-inducing passages apparently caused increasing involvement of the core structure of pain and affective empathy the more readers immersed in the text. The predominant locus of effects in the mid-cingulate cortex seems to reflect that the immersive experience was particularly facilitated by the motor component of affective empathy for our stimuli from the Harry Potter series featuring particularly vivid descriptions of the behavioural aspects of emotion.

  14. Exploring the experiences of bereaved families involved in assisted suicide in Southern Switzerland: a qualitative study.

    Science.gov (United States)

    Gamondi, Claudia; Pott, Murielle; Forbes, Karen; Payne, Sheila

    2015-06-01

    In Switzerland, helping with assisted suicide under certain conditions is not prosecuted. With approximately 300 cases annually, this leaves behind a large group of bereaved people where its consequences are mostly unknown. The study aimed to explore family involvement in decision making prior to assisted suicide, and to examine their ways of coping during the bereavement period. A qualitative interview study used the principles of Grounded Theory analysis. Eleven relatives of eight patients, who died in Southern Switzerland after assisted suicide, participated in semistructured interviews. The large majority of family members faced moral dilemmas during the decision-making phase. Their respect for patient's autonomy was a key justification to resolve dilemmas. Two types of involvement were identified: categorised as 'passive' when the decision making was located with the patient, and 'active' when assisted suicide was proposed by the family member and/or the relative was involved in some way. The relatives reported feelings of isolation during and after assisted suicide. Family members reported fear of social stigma and did not openly disclose assisted suicide as the cause of death. None of those interviewed received formal psychological support. Bereaved families express moral dilemmas, feelings of isolation and secrecy in the management of assisted suicide in Southern Switzerland. These features seem underestimated and not sufficiently recognised by the healthcare professionals. Management of assisted suicide requests should include consideration of family members' needs, in addition to those of the patient. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  15. Commitment of involved actors in the preparation of accidental and post-accident situations: European experiments

    International Nuclear Information System (INIS)

    Schneider, Th.

    2010-01-01

    The author briefly describes some approaches developed within the EURANOS European research programme between 2004 and 2009 which aims at promoting the building up of a European network (NERIS) for the management of nuclear accidental and post-accident situations. Notably, he comments the experiment which took place in the Montbeliard district where two types of radiological events have been modelled and simulated: an accident in the Fessenheim nuclear power plant with two scenarios of release, and a transportation accident with a release of radioactive caesium 137. He also evokes the Norwegian experience and some other actions in Finland, Great-Britain, Spain and Slovakia where reflections on the management of accidental and post-accident situations or crisis exercises have been organized

  16. TEACHING PHYSICS: An experiment to demonstrate the principles and processes involved in medical Doppler ultrasound

    Science.gov (United States)

    Andrews, D. G. H.

    2000-09-01

    Doppler ultrasound is widely used in medicine for measuring blood velocity. This paper describes an experiment illustrating the principles of medical Doppler ultrasound. It is designed with A-level/undergraduate physics students in mind. Ultrasound is transmitted in air and reflected from a moving target. The return signal is processed using a series of modules, so that students can discover for themselves how each stage in the instrument works. They can also obtain a quantitative value of the speed of the target.

  17. How policy on employee involvement in work reintegration can yield its opposite: employee experiences in a Canadian setting.

    Science.gov (United States)

    Maiwald, Karin; Meershoek, Agnes; de Rijk, Angelique; Nijhuis, Frans

    2013-04-01

    Canada has a long tradition of involving employee representatives in developing work reintegration policies and expects this to positively affect employee involvement to improve work reintegration success. The purpose of this study was to examine employee involvement in reintegration in a Canadian province as experienced by employees. Fourteen semi-structured interviews were held with employees in a healthcare organization. The interview topic list was based on a review of local reintegration policy documents and literature. Interviews were transcribed verbatim and analysed using ethnographic methodology. Employees do not feel in control of their reintegration trajectory. In the phase of reporting sickness absence, they wrestle with a lack of understanding on how to report in sick. In the phase of reintegration planning and coordination, they hesitate to get involved in the organization of reintegration. In the phase of reintegration plan execution, employees encounter unfulfilled expectations on interventions. Employee involvement in the organization of reintegration makes them responsible for the development of reintegration trajectories. However, they consider themselves often incapable of completing this in practice. Moreover, employees experience that their contribution can boomerang on them. • It is not that employees are not able to think along or decide on their reintegration trajectory but rather they are expected to do so at times when they cannot oversee their illness and/or recovery trajectory. • Settings out reintegration procedures that are inflexible in practice do not recognize that employee involvement in work reintegration trajectories can develop over time. • The disability management professional has a central role in organizing and supporting employee involvement in work reintegration, however, the employees do not experience this is indeed happening.

  18. Angular correlation experiments for the study of giant multipole resonances and currents of the second kind in atomic nuclei

    International Nuclear Information System (INIS)

    1986-03-01

    The project dealt with angular correlation experiments for the study of giant multipole resonances and currents of the second kind in atomic nuclei. Both partial projects were worked in the period of the report. (orig.) [de

  19. Study of correlations between photoproduced pairs of charmed particles at Experiment E831/FOCUS

    Energy Technology Data Exchange (ETDEWEB)

    Castromonte Flores, Cesar Manuel [Brazilian Center for Physics Research, Rio de Janeiro (Brazil)

    2008-08-01

    The authors present the study of the charm-pair correlations produced in photon-nucleon interactions at $\\langle$Eγ$\\rangle$ = 175 GeV/c, by the Fermilab fixed target experiment E831/FOCUS. The E831/FOCUS experiment produced and reconstructed over one million charm particles. This high statistics allows the reconstruction of more than 7000 charm-pair mesons D$\\bar{D}$, 10 times the statistic of former experiments, and also allows to get, for the first time, about 600 totally reconstructed charm-pairs in the DDs and DΛc channels. They were able to study, with some detail, the kinematical correlations between the charm and anticharm particle forming a pair, in the square transverse momentum (pT2), azimuthal angle difference (ΔΦ), rapidity difference (Δy) and the charm-pair mass variables. They observe some correlation for the longitudinal momenta, and a significant correlation for the transverse momenta of the charm and anticharm particles. They compare the experimental distributions with theoretical predictions based on the photon-gluon fusion model (PGF), for the production of c$\\bar{c}$ quarks, and the standard Lund hadronization model. These models are implemented by the PYTHIA Monte Carlo event generator. The PYTHIA program allows the inclusion, in the simulation, of non-perturbative effects that have been shown to be important for charm production. In order to compare data and simulation, they have generated two Monte Carlo samples, the first one set to favor the production of D$\\bar{D}$ pairs (MCDD2), and the second one set to favor the production of DDsand DΛc pairs, where each one uses different functions and parameters values for the theoretical models in the simulation. They observe, for the correlation distributions, that the set of parameters used by the MCDD2 model together with the intrinsic transverse momentum (k$\\perp$) of the partons inside the

  20. Fantasy Proneness Correlates With the Intensity of Near-Death Experience

    Directory of Open Access Journals (Sweden)

    Charlotte Martial

    2018-06-01

    Full Text Available Little is known about the personality characteristics of those who have experienced a “Near-Death Experience” (NDE. One interesting candidate is fantasy proneness. We studied this trait in individuals who developed NDEs in the presence (i.e., classical NDEs or absence (i.e., NDEs-like of a life-threatening situation. We surveyed a total of 228 individuals. From those, 108 qualified as NDE experiencers (i.e., Greyson NDE scale total score ≥7: 51 had their NDEs in the context of a life-threatening situation; 57 had their NDEs not related to a life-threatening situation. From those who did not meet the criteria to be considered “experiencers,” 20 had their NDE in the absence of a life-threatening situation; 50 had faced death but did not recall a NDE and finally, 50 were healthy people without a history of life threat and/or NDE. All participants completed a measure of NDE intensity (the Greyson NDE scale and a measure of fantasy proneness (the Creative Experiences Questionnaire. People reporting NDEs-like scored higher on fantasy proneness than those reporting classical NDEs, individuals whose experiences did not meet the NDE criteria and matched controls. By contrast, individuals reporting classical NDEs did not show different engagement in fantasy as matched controls. The reported intensity of the experiences was positively correlated with engagement in fantasy. Our findings support the view that strong engagement in fantasy by individuals recalling NDEs-like might make these persons more likely to report such subjective experiences when exposed to suitable physiological and/or psychological conditions (e.g., meditation, syncope.

  1. Non-Constant Learning Rates in Retrospective Experience Curve Analyses and their Correlation to Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Wei, Max [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Smith, Sarah J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sohn, Michael D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-07-16

    A key challenge for policy-makers and technology market forecasters is to estimate future technology costs and in particular the rate of cost reduction versus production volume. A related, critical question is what role should state and federal governments have in advancing energy efficient and renewable energy technologies? This work provides retrospective experience curves and learning rates for several energy-related technologies, each of which have a known history of federal and state deployment programs. We derive learning rates for eight technologies including energy efficient lighting technologies, stationary fuel cell systems, and residential solar photovoltaics, and provide an overview and timeline of historical deployment programs such as state and federal standards and state and national incentive programs for each technology. Piecewise linear regimes are observed in a range of technology experience curves, and public investments or deployment programs are found to be strongly correlated to an increase in learning rate across multiple technologies. A downward bend in the experience curve is found in 5 out of the 8 energy-related technologies presented here (electronic ballasts, magnetic ballasts, compact fluorescent lighting, general service fluorescent lighting, and the installed cost of solar PV). In each of the five downward-bending experience curves, we believe that an increase in the learning rate can be linked to deployment programs to some degree. This work sheds light on the endogenous versus exogenous contributions to technological innovation and highlights the impact of exogenous government sponsored deployment programs. This work can inform future policy investment direction and can shed light on market transformation and technology learning behavior.

  2. Correlation between the distribution of 3H-labelled enkephalin in rat brain and the anatomical regions involved in enkephalin-induced seizures.

    Science.gov (United States)

    Haffmans, J; Blankwater, Y J; Ukponmwan, O E; Zijlstra, F J; Vincent, J E; Hespe, W; Dzoljic, M R

    1983-08-01

    The correlation between the distribution of the intraventricularly (i.v.t.) administered delta agonist [3H](D-ala2,D-leu5)-enkephalin ([3H]DADL) and the anatomical regions involved in enkephalin-induced seizures has been studied in rat by using an autoradiographic method and recording of the electromyogram (EMG) and the electroencephalogram (EEG). The results indicate that within 10 min, the radioactivity of the intraventricularly administered drug reached all parts of the ventricular system, including the central canal of the spinal cord. However, within 2.5 min after the intraventricular administration of [3H]DADL, which corresponds to the onset of DADL-induced seizures, the substance appeared mainly in the left lateral ventricle and occasionally in the third ventricle. During the first 2.5 min the substance penetrated regularly into the surrounding periventricular tissue of the striatum, septum and hippocampus to a depth of about 100 microns. The most intensive and long-lasting epileptic discharges, exceeding 30 min were observed in the hippocampus, in contrast to the mild and short-lasting electrophysiological responses of the septum and corpus striatum. The experiments suggest that the short onset of enkephalin-induced excitatory phenomena is due to the rapid distribution and penetration of the substance in the surrounding periventricular tissue. According to these data, it is proposed that activation of delta opiate receptors, localized within the first 100 microns of the periventricular tissue, mainly in the hippocampus, is essential for the triggering of endorphin-induced seizure activity.

  3. Detection system for neutron β decay correlations in the UCNB and Nab experiments

    Energy Technology Data Exchange (ETDEWEB)

    Broussard, L.J., E-mail: broussardlj@ornl.gov [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Zeck, B.A. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); North Carolina State University, Raleigh, NC 27695 (United States); Adamek, E.R. [Indiana University, Bloomington, IN 47405 (United States); Baeßler, S. [University of Virginia, Charlottesville, VA 22904 (United States); Birge, N. [University of Tennessee, Knoxville, TN 37996 (United States); Blatnik, M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Cleveland State University, Cleveland, OH 44115 (United States); Bowman, J.D. [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Brandt, A.E. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); North Carolina State University, Raleigh, NC 27695 (United States); Brown, M. [University of Kentucky, Lexington, KY 40506 (United States); Burkhart, J. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Callahan, N.B. [Indiana University, Bloomington, IN 47405 (United States); Clayton, S.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Crawford, C. [University of Kentucky, Lexington, KY 40506 (United States); Cude-Woods, C. [North Carolina State University, Raleigh, NC 27695 (United States); Currie, S. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Dees, E.B. [North Carolina State University, Raleigh, NC 27695 (United States); Ding, X. [Virginia Polytechnic Institute & State University, Blacksburg, VA 24061 (United States); Fomin, N. [University of Tennessee, Knoxville, TN 37996 (United States); Frlez, E.; Fry, J. [University of Virginia, Charlottesville, VA 22904 (United States); and others

    2017-03-21

    We describe a detection system designed for precise measurements of angular correlations in neutron β decay. The system is based on thick, large area, highly segmented silicon detectors developed in collaboration with Micron Semiconductor, Ltd. The prototype system meets specifications for β electron detection with energy thresholds below 10 keV, energy resolution of ∼3 keV FWHM, and rise time of ∼50 ns with 19 of the 127 detector pixels instrumented. Using ultracold neutrons at the Los Alamos Neutron Science Center, we have demonstrated the coincident detection of β particles and recoil protons from neutron β decay. The fully instrumented detection system will be implemented in the UCNB and Nab experiments to determine the neutron β decay parameters B, a, and b.

  4. aCORN: An experiment to measure the electron-antineutrino correlation in neutron decay

    Energy Technology Data Exchange (ETDEWEB)

    Wietfeldt, F.E., E-mail: few@tulane.ed [Department of Physics, Tulane University, New Orleans, LA 70118 (United States); Byrne, J. [University of Sussex (United Kingdom); Collett, B. [Physics Department, Hamilton College, Clinton, NY 13323 (United States); Dewey, M.S. [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Jones, G.L. [Physics Department, Hamilton College, Clinton, NY 13323 (United States); Komives, A. [Physics Department, DePauw University, Greencastle, IN 46135 (United States); Laptev, A. [Department of Physics, Tulane University, New Orleans, LA 70118 (United States); Nico, J.S. [National Institute of Standards and Technology, Gaithersburg, MD 20899 (United States); Noid, G.; Stephenson, E.J. [Indiana University Cyclotron Facility, Bloomington, IN 47408 (United States); Stern, I.; Trull, C. [Department of Physics, Tulane University, New Orleans, LA 70118 (United States); Yerozolimsky, B.G. [Physics Department, Harvard University, Cambridge, MA 02139 (United States)

    2009-12-11

    The aCORN experiment is designed to make a precision (<1%) measurement of the electron-antineutrino angular correlation (a-coefficient) in neutron beta decay. It uses a new method proposed in 1996 by Yerozolimsky and Mostovoy. Electrons and recoil protons from neutron decay in a cold beam are detected in coincidence. The momenta of the particles are selected so that the protons form two kinematically distinct time-of-flight groups as a function of electron energy. The count rate asymmetry in these two groups is proportional to the a-coefficient. Precision spectroscopy of the protons is not required. The apparatus is currently under construction. It will be integrated and tested at the Indiana University Cyclotron Facility (IUCF) and then moved to the NIST Center for Neutron Research for the initial physics run.

  5. Correlation of weight-based objectifying experiences with depression and eating disorder in overweight women

    Directory of Open Access Journals (Sweden)

    Leila Khabir

    2015-06-01

    Full Text Available Background: This study was carried out to investigate the correlation of self-objectification, internalized weight bias and body image concern with depression and eating disorder Methods: A total of 200 female students with overweight and obesity were selected using convenience random sampling among female students with overweight and obesity referring to Shiraz sport clubs in 2013. They responded to Stigmatizing Situations Inventory (SSI, Trait Self- Objectification Questionnaire (TSOQ, Weight Bias Internalization Scale (WBIS, Body Image Concern Inventory (BICI, Center for Epidemiological Studies- Depression Scale (CES-D and Eating Disorder Diagnostic Scale (EDDS. Data were analyzed by structural equation modeling (SEM. Results: Result showed that self-objectification, internalized weight bias and body image concern can mediate the relationship of weight-based objectifying experiences with depression and eating disorder. Conclusion: The findings of this study showed that fitness index of the proposed model can acceptably fit the data.

  6. A study of parton fragmentation using photon-hadron correlation with the ALICE experiment at LHC

    International Nuclear Information System (INIS)

    Arbor, N.

    2013-01-01

    The strong interaction theory, Quantum Chromodynamic (QCD), predicts a new phase of nuclear matter at very high temperature and/or very high density. This state is composed of deconfined quarks and gluons known as the quark-gluon plasma (QGP). The measurement of its composition and properties is a challenge for the nuclear physics of the 21. century and should lead to a better understanding of the fundamental symmetries and mechanisms related to the quarks confinement inside hadrons and the strong interaction generally.The Large Hadron Collider (LHC) accelerator at CERN (European Organization for Nuclear Research) allows to reach the thermodynamic conditions required to create the quark-gluon plasma using ultra-relativistic heavy ion collisions (Pb). The ALICE experiment (A Large Ion Collider Experiment) allows to access several probes to characterize the QGP through particles reconstruction and. Among these probes, high energy parton energy loss is used to access medium characteristics such as density or temperature. Parton energy loss is estimated from the modification of the energy distribution of hadrons produced by fragmentation.This thesis is dedicated to the photon-hadron correlations analysis in order to study the modification of the parton fragmentation due to the quark-gluon plasma. First part of this thesis is devoted to the characterization of the electromagnetic calorimeter (EMCal), the central detector for energy measurement and photon identification. The second part is dedicated to the photon-hadron correlation measurement, for the 7 TeV proton-proton collisions and 2.76 TeV Lead-Lead collisions. An important work has been done to improve the prompt photon identification, one of the key point of this analysis. (author) [fr

  7. A study of parton fragmentation using photon-hadron correlation with the ALICE experiment at LHC

    International Nuclear Information System (INIS)

    Arbor, Nicolas

    2013-01-01

    The strong interaction theory, Quantum Chromodynamic (QCD), predicts a new phase of nuclear matter at very high temperature and/or very high density. This state is composed of deconfined quarks and gluons known as the quark-gluon plasma (QGP). The measurement of its composition and properties is a challenge for the nuclear physics of the 21. century and should lead to a better understanding of the fundamental symmetries and mechanisms related to the quarks confinement inside hadrons and the strong interaction generally. The Large Hadron Collider (LHC) accelerator at CERN (European Organization for Nuclear Research) allows to reach the thermodynamic conditions required to create the quark-gluon plasma using ultra-relativistic heavy ion collisions (Pb). The ALICE experiment (A Large Ion Collider Experiment) allows to access several probes to characterize the QGP through particles reconstruction and. Among these probes, high energy parton energy loss is used to access medium characteristics such as density or temperature. Parton energy loss is estimated from the modification of the energy distribution of hadrons produced by fragmentation. This thesis is dedicated to the photon-hadron correlations analysis in order to study the modification of the parton fragmentation due to the quark-gluon plasma. First part of this thesis is devoted to the characterization of the electromagnetic calorimeter (EMCal), the central detector for energy measurement and photon identification. The second part is dedicated to the photon-hadron correlation measurement, for the 7 TeV proton-proton collisions and 2.76 TeV Lead-Lead collisions. An important work has been done to improve the prompt photon identification, one of the key point of this analysis. (author) [fr

  8. Male involvement in reproductive health among scheduled tribe: experience from Khairwars of central India.

    Science.gov (United States)

    Saha, Kalyan B; Singh, Neeru; Chatterjee Saha, Uma; Roy, Jyotirmoy

    2007-01-01

    Indian tribal men's lack of participation in reproductive health not only damages their own health, but also contributes to the reproductive ill health of their female partners and children. In India the involvement of men in such matters is a new concept. There is a paucity of data particularly on Scheduled tribesmen's knowledge and the extent of their participation in reproductive health. This inhibits planning. The present study aims to understand the involvement of Scheduled tribesmen in reproductive health and the barriers to their involvement by generating a database from the Khairwar tribe of Central India. A door-to-door survey on knowledge, attitude and practice relating to aspects of reproductive health was conducted by canvassing a pre-designed interview schedule among 15-40 year old, currently married Khairwar males in the Sidhi district of Madhya Pradesh, India. As far as reproductive morbidity is concerned, only 17% of the respondents had heard of HIV/AIDS, and most had no proper knowledge of its transmission. Although 74% of the respondents had heard about reproductive tract infections, the majority of them were unaware of the mechanism of transmission and seriousness of the problem. The duel role of condoms, both as a method of family planning and a protective measure against sexually transmitted infections, was also unknown to them. Approximately 59% of the males were aware of family planning but only 13% were using any method (mostly female sterilization) at the time of survey. Their view on the ideal number of children (3.56) exceeded the actual number of children born and living. High infant and child mortality influenced their preference for higher fertility. Very few among them (29%) had knowledge of antenatal care. They expressed faulty knowledge, myths and unhelpful attitudes towards sexual health matters. The study revealed the male Scheduled tribe population's lack of knowledge and misinformation regarding male sexual health issues, the

  9. Involving Freight Transport Actors in Production of Knowledge - Experience with Future Workshop Methodology

    DEFF Research Database (Denmark)

    Jespersen, Per Homann; Drewes, Lise

    2005-01-01

    the experience and knowledge of actors in the freight transport sector are included directly in a scientific process in order to develop future and strategic studies. Future research is often produced as desktop research and presented as the results of scientists’ forecasting and scenario building...... in the format of a future workshop included freight transport stakeholders in the research process in order to produce knowledge meeting scientific quality criteria and at the same time in a form suitable for improving the problem solving capabilities of the participants....

  10. Personality Characteristics Of Teachers Involved In The Delivery Of Primary Healthy Care (Sevagram Experiment

    Directory of Open Access Journals (Sweden)

    Singh D

    1990-01-01

    Full Text Available An attempt was made to study the personality traits influencing the performance of 17 primary school teachers selected under ICMR project in Wardha district, to investigate feasibility and effectiveness of their involvement as primary health care workers vis-Ã -vis the 19 community health volunteers introduced by the State Government in the non-teacher villages of the project at the same time. The results indicated that both the teachers and community health volunteers preferred preventive and promotive health tasks and they showed no significant difference on the motivation and leadership orientation scale. The teachers, because of their job security and promotional avenues were satisfied with their achievements and were full of hopes and aspirations but the same was not true with the community health volunteers. This was due to their comparatively poor economic conditions and unstable sources of livelihood.

  11. Experience in the analysis of accidents and incidents involving the transport of radioactive materials

    International Nuclear Information System (INIS)

    Warner-Jones, S.M.; Hughes, J.S.; Shaw, K.B.

    2002-01-01

    Some half a million packages containing radioactive materials are transported to, from and within the UK annually. Accidents and incidents involving these shipments are rare. However, there is always the potential for such an event, which could lead to a release of the contents of a package or an increase in radiation level caused by damaged shielding. These events could result in radiological consequences for transport workers. As transport occurs in the public environment, such events could also lead to radiation exposures of members of the public. The UK Department for Transport (DfT), together with the Health and Safety Executive (HSE) have supported, for almost 20 years, work to compile, analyse and report on accidents and incidents that occur during the transport of radioactive materials. Annual reports on these events have been produced for twelve years. The details of these events are recorded in the Radioactive Materials Transport Event Database (RAMTED) maintained by the National Radiological Protection Board on behalf of the DfT and HSE. Information on accidents and incidents dates back to 1958. RAMTED currently includes information of 708 accidents and incidents, covering the period 1958 to 2000. This paper presents a summary of the data covering this period, identifying trends and lessons learned together with a discussion of some examples. It was found that, historically, the most significant exposures were received as a result of accidents involving the transport of industrial radiography sources. However, the frequency and severity of these events has decreased considerably in the later years of this study due to improvements in training, awareness and equipment. The International Atomic Energy Agency and the Nuclear Energy Agency, have established the international nuclear event scale (INES), which is described in detail in a users' guide. The INES has been revised to fully include transport events, and the information in RAMTED has been reviewed

  12. Involving the public in decision-making at federal facilities: The Department of Energy experience

    International Nuclear Information System (INIS)

    Gesalman, C.M.

    1996-01-01

    The Department of Energy is involved in cleanup of a wide variety of sites used in the development and production of nuclear weapons. Substantial and increasing efforts have been made to involve the public in the planning and implementation of the cleanup projects. Early in the program, public participation was mainly an information transfer effort. More recently, innovative techniques have been used to increase public understanding of the tradeoffs required in making cleanup decisions (e.g., more stringent cleanup standards lead to higher costs). Sites now realize that relationships are key and are working to develop them. Advisory boards have been established at several sites. The methods of forming the boards have varied from site to site, as have the size of the group and the issues addressed. The effectiveness of the boards in their goal of improving public participation at the sites will be evaluated in the next fiscal year. DOE has sought public input on an increasing number of issues, such as future use of its facilities, environmental justice concerns, and budget development. Assumptions about future use of sites are crucial to setting realistic cleanup standards and controlling costs. Decisions made in the early phases of the budget process are now based in part on stakeholder input regarding priorities; for example, stakeholder concerns about and support for emphasizing plutonium cleanup at Rocky Flats have led to changes in priorities between the materials stabilization and environmental restoration programs. Environmental justice has become an increasing issue; sites must ensure that public participation programs effectively reach minority and low-income populations

  13. The effect of sensory brand experience and involvement on brand equity directly and indirectly through consumer brand engagement

    OpenAIRE

    Hepola, Janne; Karjaluoto, Heikki; Hintikka, Anni

    2017-01-01

    Purpose This study aims to examine the effect of sensory brand experience and involvement on brand equity directly and indirectly through cognitive, emotional and behavioral consumer brand engagement (CBE). Design/methodology/approach A survey was administered to the customers of a Finnish tableware brand using relevant Facebook channels. A total of 1,390 responses were analyzed using partial least squares structural equation modeling. Findings The empirical findings suggest ...

  14. Correlations between dioxin-like and indicators PCBs: Potential consequences for environmental studies involving fish or sediment

    International Nuclear Information System (INIS)

    Babut, M.; Miege, C.; Villeneuve, B.; Abarnou, A.; Duchemin, J.; Marchand, P.; Narbonne, J.F.

    2009-01-01

    Among the numerous PCB congeners, most of the dioxin-like PCBs (DL-PCBs) need to be characterized by hyphenated techniques. It has been shown in several instances that these congeners are well related to the total PCB content in fish. We examined datasets collected mainly in France, on freshwater and marine fish and sediments. A statistical model linking DL- and indicator PCBs was developed for a dataset composed of freshwater fishes, and proved to predict well DL-PCBs from indicator PCBs in all other fish sets, including marine ones. Type II error rates remained low in almost all fish sets. A similar correlation was observed in sediments. Non-dioxin-like PCBs elicit various adverse effects and represent 95% of the total PCBs. A European guideline for them is needed; the correlation between DL- and indicator PCBs could help develop this standard in the future. - Dioxin-like PCBs in fish and maybe sediments are rather well predicted by indicator PCBs.

  15. Subcriticality determination by a new time-domain correlation experiment with a 252Cf neutron source

    International Nuclear Information System (INIS)

    Nishina, K.; Yamane, Y.; Ishiguro, S.; Miyoshi, Y.; Suzaki, T.; Kobayahi, I.

    1985-01-01

    As a candidate for the on-site subcriticality-monitoring method, a new time-domain correlation experiment is proposed. Hinted by the Cf-252 detector method of Mihalczo, three covariances are taken between the count of three detectors; namely an ionization chamber with Cf-252 coating, and two He-3 proportional counters. A ratio Q is formed from the three quantities such that it does not depend either on detector efficiencies or counting gate duration T, and then related to reactivity. A formulation is given deriving a theoretical expression for this Q, with the effect of higher spatial modes included. Experiments were carried out with a loading at Tank-type Critical Assembly of Japan Atomic Energy Research Institute, which is a slightly-enriched, and light-water moderated system. With fundamental mode approximation adopted in the data processing, reasonable agreements are observed between the present method and the reactivity scale that has been calibrated by water-level variety. The possibility of the present method is to be investigated further beyond the range of 7$ reported

  16. Influence of transmutation and high neutron exposure on materials used in fission-fusion correlation experiments

    International Nuclear Information System (INIS)

    Garner, F.A.

    1990-07-01

    This paper explores the response of three different materials to high fluence irradiation as observed in recent fusion-related experiments. While helium at fusion-relevant levels influences the details of the microstructure of Fe--Cr--Ni alloys somewhat, the resultant changes in swelling and tensile behavior are relatively small. Under conditions where substantially greater-than-fusion levels of helium are generated, however, an extensive refinement of microstructure can occur, leading to depression of swelling at lower temperatures and increased strengthening at all temperatures studied. The behavior of these alloys is dominated by their tendency to converge to saturation microstructures which encourage swelling. Irradiations of nickel are dominated by its tendency to develop a different type of saturation microstructure that discourages further void growth. Swelling approaches saturation levels that are remarkably insensitive to starting microstructure and irradiation temperature. The rate of approach to saturation is very sensitive to variables such as helium, impurities, dislocation density and displacement rate, however. Copper exhibits a rather divergent response depending on the property measured. Transmutation of copper to nickel and zinc plays a large role in determining electrical conductivity but almost no role in void swelling. Each of these three materials offers different challenges in the interpretation of fission-fusion correlation experiments

  17. Volunteer stream monitoring: Do the data quality and monitoring experience support increased community involvement in freshwater decision making?

    Directory of Open Access Journals (Sweden)

    Richard G. Storey

    2016-12-01

    Full Text Available Recent freshwater policy reforms in New Zealand promote increased community involvement in freshwater decision making and management. Involving community members in scientific monitoring increases both their knowledge and their ability to discuss this knowledge with professionals, potentially increasing their influence in decision-making processes. However, these interactions rarely occur because, in particular, of perceptions that volunteer-collected data are unreliable. We assessed the agreement between volunteer (community group and local government (regional council data at nine stream sites across New Zealand. Over 18 months, community groups and regional council staff monitored, in parallel, a common set of water quality variables, physical habitat, periphyton and benthic macroinvertebrates that are routinely used by regional councils for statutory state of environment reporting. Community groups achieved close agreement (correlations ≥ 0.89, bias < 1% with regional councils for temperature, electrical conductivity, visual water clarity, and Escherichia coli. For dissolved oxygen, nitrate, and pH, correlations were weaker (0.2, 0.53, and 0.4, respectively. Volunteer assessments of physical habitat were as consistent over time as those of councils. For visual assessments of thick periphyton growths (% streambed cover, volunteers achieved a correlation of 0.93 and bias of 0.1% relative to councils. And for a macroinvertebrate biotic index that indicates water and habitat quality, correlation was 0.88, bias was < 5%, and the average difference was 12% of the index score. Volunteers showed increased awareness of local freshwaters, understanding of stream ecosystems, and attentiveness to local and national freshwater issues. Most volunteers had shared their knowledge and interest with others in their community. Most groups had developed relationships with their regional council, and some volunteers became more interested in engaging in

  18. [The experience of someone involved in the psychiatry reform in Brazil].

    Science.gov (United States)

    Marzano, Maria Luisa Rietra; de Sousa, Célia Antunes C

    2003-01-01

    This report is a descriptive study based on bibliographic reviews, developed in the Health Policies course, a subject which is part of the Master's degree from the University of Rio de Janeiro (UNIRIO). Our objective is to report on our experiences working with psychosocial care, which has been our goal over the last 4 years, with an approach on the strategies adopted by the Brazilian Health Department, directed toward restructuring mental health care in Brazil. One realizes the need for objective interventions in order to make this process effective, such as the construction of a solid and amplified network for mental health care, the municipalization of health services which would reduce the risk of a fragmentation in services provided and would promote participation of family members and society in caring and reinserting mentally-ill patients.

  19. Enhancing Local Community’s Involvement and Empowerment through Practicing Cittaslow: Experiences from Goolwa, South Australia

    Directory of Open Access Journals (Sweden)

    Park Eerang

    2014-01-01

    Full Text Available This study attempted to investigate how and the extent to which Cittaslow philosophy and practice enhanced local community’s involvement and empowerment in relation to tourism development from the sustainability’s perspective. As an empirical study, a series of in-depth interviews with key stakeholders including local government, local business, and local community’s members were conducted in Goolwa, the first Australian accredited Cittaslow town since 2007, located in South Australia. The results indicated that to a greater extent the accreditation and practice of Cittaslow philosophy in Goolwa increased a stronger and more effective collaboration amongst local community, business and residents as an essential element for achieving sustainability in tourism development. Not only did it encourage the local community’s participation in decision making process from the beginning of tourism development, but also revitalised the locality and sense of place of Goolwa through promoting local specialities and produces, in particular food and wine products. The results also suggested that psychological and social aspects of local community’s empowerment have been significantly enhanced after the establishment of Cittaslow. Yet, the economic empowerment of the local community was less experienced.

  20. Extremity doses of medical staff involved in interventional radiology and cardiology: Correlations and annual doses (hands and legs)

    International Nuclear Information System (INIS)

    Krim, S.; Brodecki, M.; Carinou, E.; Donadille, L.; Jankowski, J.; Koukorava, C.; Dominiek, J.; Nikodemova, D.; Ruiz-Lopez, N.; Sans-Merce, M.; Struelens, L.; Vanhavere, F.

    2011-01-01

    An intensive measurement campaign was launched in different hospitals in Europe within work package 1 of the ORAMED project (Optimization of RAdiation protection for MEDical staff). Its main objective was to obtain a set of standardized data on extremity and eye lens doses for staff in interventional radiology (IR) and cardiology (IC) and to optimize staff protection. The monitored procedures were divided in three main categories: cardiac, general angiography and endoscopic retrograde cholangio-pancreatography(ERCP) procedures. Using a common measurement protocol, information such as the protective equipment used (lead table curtain, transparent lead glass ceiling screen, patient shielding, whole body shielding or special cabin etc.) as well as Kerma Area Product (KAP) values and access of the catheter were recorded. This study was performed with a final database of more than 1300 procedures performed in 34 European hospitals. Its objectives were firstly to determine if the measured extremity doses could be correlated to the KAP values; secondly to check if the doses to the eyes could be linked to the doses to the hands (finger or wrist positions) and finally if the doses to the fingers could be estimated based on the doses to the wrists. General correlations were very difficult to find and their strength was mostly influenced by three main parameters: the X-ray tube configuration, the room collective radioprotective equipment and the access of the catheter. The KAP value can provide a simple mean to estimate the extremity doses of the operator given that it is assessed correctly for the operator when he is actually using the X-ray tube. Moreover, this study showed that the doses to the left finger are strongly correlated to the doses to the left wrist when no ceiling shield is used. It is also possible to estimate the doses to the eyes given the doses to the left finger or left wrist but the X-ray tube configuration and the access have to be considered. The annual

  1. Expression of Genes Involved in Cellular Adhesion and Extracellular Matrix Remodeling Correlates with Poor Survival of Patients with Renal Cancer.

    Science.gov (United States)

    Boguslawska, Joanna; Kedzierska, Hanna; Poplawski, Piotr; Rybicka, Beata; Tanski, Zbigniew; Piekielko-Witkowska, Agnieszka

    2016-06-01

    Renal cell carcinoma is the most common highly metastatic kidney malignancy. Adhesion has a crucial role in the metastatic process. TGF (transforming growth factor)-β1 is a pleiotropic cytokine that influences cancerous transformation. We hypothesized that 1) changes in the expression of adhesion related genes may influence survival rate of patients with renal cell carcinoma and 2) TGF-β1 may contribute to changed expression of adhesion related genes. Two-step quantitative real-time polymerase chain reaction arrays were used to analyze the expression of adhesion related genes in 77 tumors and matched pair controls. The prognostic significance of genes was evaluated in TCGA (The Cancer Genome Atlas) data on 468 patients with renal cell carcinoma. Quantitative real-time polymerase chain reaction and Western blot were applied for TGF-β1 analysis. TGF-β1 mediated regulation of gene expression was analyzed by TGF-β1 supplementation of Caki-2 cells and quantitative real-time polymerase chain reaction. The expression of 19 genes related to adhesion and extracellular matrix remodeling was statistically significantly disturbed in renal cell carcinoma compared with controls. The 10-gene expression signature (COL1A1, COL5A1, COL11A1, FN1, ICAM1, ITGAL, ITGAM, ITGB2, THBS2 and TIMP1) correlated with poor survival (HR 2.85, p = 5.7e-10). TGF-β1 expression was 22 times higher in renal cell carcinoma than in controls (p adhesion and extracellular matrix remodeling develops early during renal cell carcinoma carcinogenesis and correlates with poor survival. TGF-β1 contributes to changed expression of extracellular matrix and adhesion related genes. Bioinformatic analysis performed on a broad panel of cancers of nonkidney origin suggests that disturbed expression of genes related to extracellular matrix and adhesion may be a universal feature of cancerous progression. Copyright © 2016 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All

  2. Cortical activation during Braille reading is influenced by early visual experience in subjects with severe visual disability: a correlational fMRI study.

    Science.gov (United States)

    Melzer, P; Morgan, V L; Pickens, D R; Price, R R; Wall, R S; Ebner, F F

    2001-11-01

    Functional magnetic resonance imaging was performed on blind adults resting and reading Braille. The strongest activation was found in primary somatic sensory/motor cortex on both cortical hemispheres. Additional foci of activation were situated in the parietal, temporal, and occipital lobes where visual information is processed in sighted persons. The regions were differentiated most in the correlation of their time courses of activation with resting and reading. Differences in magnitude and expanse of activation were substantially less significant. Among the traditionally visual areas, the strength of correlation was greatest in posterior parietal cortex and moderate in occipitotemporal, lateral occipital, and primary visual cortex. It was low in secondary visual cortex as well as in dorsal and ventral inferior temporal cortex and posterior middle temporal cortex. Visual experience increased the strength of correlation in all regions except dorsal inferior temporal and posterior parietal cortex. The greatest statistically significant increase, i.e., approximately 30%, was in ventral inferior temporal and posterior middle temporal cortex. In these regions, words are analyzed semantically, which may be facilitated by visual experience. In contrast, visual experience resulted in a slight, insignificant diminution of the strength of correlation in dorsal inferior temporal cortex where language is analyzed phonetically. These findings affirm that posterior temporal regions are engaged in the processing of written language. Moreover, they suggest that this function is modified by early visual experience. Furthermore, visual experience significantly strengthened the correlation of activation and Braille reading in occipital regions traditionally involved in the processing of visual features and object recognition suggesting a role for visual imagery. Copyright 2001 Wiley-Liss, Inc.

  3. A correlative study of CT findings and pulmonary function in patients with pulmonary involvement during the active phase of rheumatoid arthritis

    International Nuclear Information System (INIS)

    Zhu Xiaolei; Xu Defu

    2006-01-01

    Objective: It is a correlative study of CT findings and pulmonary function in patients with pulmonary involvement during the active phase of rheumatoid arthritis. Methods: The CT images of 28 cases of pulmonary involvement during the active phase of rheumatoid arthritis were retrospectively analyzed. The pulmonary abnormalities revealed on CT images including distribution and extend of the lesions were quantitatively analyzed and scored. The correlation of CT scores with the results of pulmonary function tests was compared statistically. Results: Interlobular septa thickening was shown in 16 cases; ground-glass opacification was revealed in 14 cases; irregular lines were found in 11 cases; bronchiolectasis was noted in 7 cases; micro nodules were demonstrated in 4 cases; and honey combing alteration was visualized in 3 cases. The abnormality most frequent seen on CT images was reticular shadow and ground-glass opacification. CT visual score had a negative correlation with pulmonary function. Conclusion: CT visual score provides quantitative evaluation of the pulmonary involvement during the active phase of rheumatoid arthritis, and also indicates the pulmonary function and prognosis as well. (authors)

  4. Subclinical interstitial lung involvement in rheumatic diseases. Correlations of high-resolution Computed Tomography patterns with functional and cytologic findings

    International Nuclear Information System (INIS)

    Salaffi, F.; Baldelli, S.

    1999-01-01

    The aims of this study were to quantify the severity and extent of subclinical interstitial lung disease as depicted on HRCT and to study the relationship between the patterns of lung disease quantified by HRCT and the functional parameters and bronchoalveolar lavage findings in patients with rheumatic diseases. The results confirm that HRCT is a sensitive tool in detecting interstitial lung disease in patients with rheumatic diseases with no signs and symptoms of pulmonary involvement. The relationship between the different HRCT patterns and bronchoalveolar lavage cell profiles can identify patients at higher risk of developing irreversible lung fibrosis. A long-term, prospective follow-up study is needed to determine whether these patients will develop over pulmonary disease [it

  5. Pair natural orbital and canonical coupled cluster reaction enthalpies involving light to heavy alkali and alkaline earth metals: the importance of sub-valence correlation

    KAUST Repository

    Minenkov, Yury

    2017-03-07

    In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes of Li, Be, Na, Mg, Ca, Sr, Ba and Pb(ii). Two strategies were investigated: in the former, only valence electrons were included in the correlation treatment, giving rise to the computationally very efficient FC (frozen core) approach; in the latter, all non-ECP electrons were included in the correlation treatment, giving rise to the AE (all electron) approach. Apart from reactions involving Li and Be, the FC approach resulted in non-homogeneous performance. The FC approach leads to very small errors (<2 kcal mol-1) for some reactions of Na, Mg, Ca, Sr, Ba and Pb, while for a few reactions of Ca and Ba deviations up to 40 kcal mol-1 have been obtained. Large errors are both due to artificial mixing of the core (sub-valence) orbitals of metals and the valence orbitals of oxygen and halogens in the molecular orbitals treated as core, and due to neglecting core-core and core-valence correlation effects. These large errors are reduced to a few kcal mol-1 if the AE approach is used or the sub-valence orbitals of metals are included in the correlation treatment. On the technical side, the CCSD(T) and DLPNO-CCSD(T) results differ by a fraction of kcal mol-1, indicating the latter method as the perfect choice when the CPU efficiency is essential. For completely black-box applications, as requested in catalysis or thermochemical calculations, we recommend the DLPNO-CCSD(T) method with all electrons that are not covered by effective core potentials included in the correlation treatment and correlation-consistent polarized core valence basis sets of cc-pwCVQZ(-PP) quality.

  6. Global Indicators Analysis and Consultancy Experience Insights into Correlation between Entrepreneurial Activities and Business Environment

    Directory of Open Access Journals (Sweden)

    Jovan Krivokapić

    2015-02-01

    Full Text Available Many researches and practical experiences clearly indicate the existence of a strong relationship between entrepreneurial activities and the business environment in which these activities are initiated. Although this topic has been quite ignored until the late twentieth century, a lot of studies and consulting practice have contributed to the fact that there are now a number of theories concerning mentioned correlation. These theories aim to offer a model that would provide better utilization of the possibilities from the business environment which could be very important for the development from both macroeconomic and microeconomic aspects. An increasing number of articles on this topic says enough about its importance, and numerous researches by many reputable globally recognized institutions go in favor of this claim. There are many indicators that observe the economic situation in a country or a region from different aspects, so the analyses of these indicators make it possible to determine the specific relationships between entrepreneurial activities and the local and the global business environment. Given the complexity of these relations, the impact cannot be observed partially, without taking into consideration other important factors, but more detailed analyses, however, result in some useful conclusions, which in the proper context can have a positive impact on many economic factors. It is very important to emphasize the fact that the correlation between the business environment and entrepreneurial activities is bidirectional, since this influence is mutual, so that changes in one of these factors can and usually cause some modifications in the other. Frequent series of such iterations actually lead to changes in the business environment, while entrepreneurial activity changes its shape and affects the economy of a country or a region, which is of particular importance for its competitiveness in the era of globalization.

  7. Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity

    Science.gov (United States)

    Hu, Heng; Doll, Danielle N.; Sun, Jiahong; Lewis, Sara E.; Wimsatt, Jeffrey H.; Kessler, Matthew J.; Simpkins, James W.; Ren, Xuefang

    2016-01-01

    Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severity as well as reveal a possible mitochondrial mechanism in the association of body temperature and stroke severity. Lipopolysaccharide (LPS) compromises mitochondrial oxidative phosphorylation in cerebrovascular endothelial cells (CVECs) and worsens murine experimental stroke. In this study, we report that LPS (0.1 mg/kg) exacerbates stroke infarction and neurological deficits, in the mean time LPS causes temporary hypothermia in the hyperacute stage during 6 hours post-stroke. Lower body temperature is associated with worse infarction and higher neurological deficit score in the LPS-stroke study. However, warming of the LPS-stroke mice compromises animal survival. Furthermore, a high dose of LPS (2 mg/kg) worsens neurological deficits, but causes persistent severe hypothermia that conceals the LPS exacerbation of stroke infarction. Mitochondrial respiratory chain complex I inhibitor, rotenone, replicates the data profile of the LPS-stroke study. Moreover, we have confirmed that rotenone compromises mitochondrial oxidative phosphorylation in CVECs. Lastly, the pooled data analyses of a large sample size (n=353) demonstrate that stroke mice have lower body temperature compared to sham mice within 6 hours post-surgery; the body temperature is significantly correlated with stroke outcomes; linear regression shows that lower body temperature is significantly associated with higher neurological scores and larger infarct volume. We conclude that post-stroke body temperature predicts stroke severity and mitochondrial impairment in CVECs plays a pivotal role in this hypothermic response. These novel findings suggest that body temperature is prognostic for

  8. NBME subject examination in surgery scores correlate with surgery clerkship clinical experience.

    Science.gov (United States)

    Myers, Jonathan A; Vigneswaran, Yalini; Gabryszak, Beth; Fogg, Louis F; Francescatti, Amanda B; Golner, Christine; Bines, Steven D

    2014-01-01

    Most medical schools in the United States use the National Board of Medical Examiners Subject Examinations as a method of at least partial assessment of student performance, yet there is still uncertainty of how well these examination scores correlate with clinical proficiency. Thus, we investigated which factors in a surgery clerkship curriculum have a positive effect on academic achievement on the National Board of Medical Examiners Subject Examination in Surgery. A retrospective analysis of 83 third-year medical students at our institution with 4 unique clinical experiences on the general surgery clerkship for the 2007-2008 academic year was conducted. Records of the United States Medical Licensing Examination Step 1 scores, National Board of Medical Examiners Subject Examination in Surgery scores, and essay examination scores for the groups were compared using 1-way analysis of variance testing. Rush University Medical Center, Chicago IL, an academic institution and tertiary care center. Our data demonstrated National Board of Medical Examiners Subject Examination in Surgery scores from the group with the heavier clinical loads and least time for self-study were statistically higher than the group with lighter clinical services and higher rated self-study time (p = 0.036). However, there was no statistical difference of National Board of Medical Examiners Subject Examination in Surgery scores between the groups with equal clinical loads (p = 0.751). Students experiencing higher clinical volumes on surgical services, but less self-study time demonstrated statistically higher academic performance on objective evaluation, suggesting clinical experience may be of higher value than self-study and reading. Copyright © 2014 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  9. Development of an X-ray delay unit for correlation spectroscopy and pump-probe experiments

    Energy Technology Data Exchange (ETDEWEB)

    Roseker, Wojciech

    2008-07-15

    Probing condensed matter on time scales ranging from femtoseconds to nanoseconds will be one of the key topics for future X-ray Free Electron Laser (XFEL) sources. The accessible time windows are, however, compromised by the intrinsic time structure of the sources. One way to overcome this limitation is the usage of a time delay unit. A prototype device capable of splitting an X-ray pulse into two adjustable fractions, delaying one of them with the aim to perform X-ray Photon Correlation Spectroscopy and pump-probe type studies was designed and manufactured. The device utilizes eight perfect crystals in vertical 90 scattering geometry. Its performance has been verified with 8.39 keV and 12.4 keV Xrays at various synchrotron sources. The measured throughput of the device with a Si(333) monochromator at 8.39 keV under ambient conditions is 0.6%. The stability was verified at 12.4 keV and operation without realignment and feedback was possible for more than 30 minutes. Time delays up to 2.95 ns have been achieved. The highest resolution achieved in an experiment was 15.4 ps, a value entirely determined by the diagnostics system. The influence of the delay unit optics on the coherence properties of the beam was investigated by means of Fraunhofer diffraction and static speckle analysis. The obtained high fringe visibility and contrast values larger than 23% indicate the feasibility of performing coherence based experiments with the delay line. (orig.)

  10. Amyloidosis involving the respiratory system: 5-year′s experience of a multi-disciplinary group′s activity

    Directory of Open Access Journals (Sweden)

    Raffaele Scala

    2015-01-01

    Full Text Available Amyloidosis may involve the respiratory system with different clinical-radiological-functional patterns which are not always easy to be recognized. A good level of knowledge of the disease, an active integration of the pulmonologist within a multidisciplinary setting and a high level of clinical suspicion are necessary for an early diagnosis of respiratory amyloidosis. The aim of this retrospective study was to evaluate the number and the patterns of amyloidosis involving the respiratory system. We searched the cases of amyloidosis among patients attending the multidisciplinary rare and diffuse lung disease outpatients′ clinic of Pulmonology Unit of the Hospital of Arezzo from 2007 to 2012. Among the 298 patients evaluated during the study period, we identified three cases of amyloidosis with involvement of the respiratory system, associated or not with other extra-thoracic localizations, whose diagnosis was histo-pathologically confirmed after the pulmonologist, the radiologist, and the pathologist evaluation. Our experience of a multidisciplinary team confirms that intra-thoracic amyloidosis is an uncommon disorder, representing 1.0% of the cases of rare and diffuse lung diseases referred to our center. The diagnosis of the disease is not always easy and quick as the amyloidosis may involve different parts of the respiratory system (airways, pleura, parenchyma. It is therefore recommended to remind this orphan disease in the differential diagnosis of the wide clinical scenarios the pulmonologist may intercept in clinical practice.

  11. Adverse Childhood Experiences and the Risk of Criminal Justice Involvement and Victimization Among Homeless Adults With Mental Illness.

    Science.gov (United States)

    Edalati, Hanie; Nicholls, Tonia L; Crocker, Anne G; Roy, Laurence; Somers, Julian M; Patterson, Michelle L

    2017-12-01

    Exposure to adverse childhood experiences (ACEs) is highly prevalent among homeless individuals and is associated with negative consequences during homelessness. This study examined the effect of ACEs on the risk of criminal justice involvement and victimization among homeless individuals with mental illness. The study used baseline data from a demonstration project (At Home/Chez Soi) that provided Housing First and recovery-oriented services to homeless adults with mental illness. The sample was recruited from five Canadian cities and included participants who provided valid responses on an ACEs questionnaire (N=1,888). Fifty percent reported more than four types of ACE, 19% reported three or four types, 19% reported one or two, and 12% reported none. Rates of criminal justice involvement and victimization were significantly higher among those with a history of ACEs. For victimization, the association was significant for all ten types of ACE, and for justice involvement, it was significant for seven types. Logistic regression models indicated that the effect of cumulative childhood adversity on the two outcomes was significant regardless of sociodemographic factors, duration of homelessness, and psychiatric diagnosis, with one exception: the relationship between cumulative childhood adversity and criminal justice involvement did not remain significant when the analysis controlled for a diagnosis of posttraumatic stress disorder and substance dependence. Findings support the need for early interventions for at-risk youths and trauma-informed practice and violence prevention policies that specifically target homeless populations.

  12. Correlations between nuclear data and results of integral slab experiments. Case of hafnium

    International Nuclear Information System (INIS)

    Palau, J.M.

    1997-01-01

    The aim of this thesis was to evaluate how much integral slab experiments can both reduce discrepancies between experimental results and calculations, and improve the knowledge of hafnium isotopes neutronic parameters by an adapted sensitivity and uncertainty method. A statistical approach, based on the generalized least squares method and perturbation theory, has been incorporated into our calculation system in order to deduce microscopic cross-section adjustments from observed integral measurements on this particular 'mock-up' reactor. In this study it has been established that the correlations between integral parameters and hafnium capture cross-sections enable specific variations in the region of resolved resonances at the level of multigroup and punctual cross-sections recommended data (JEF-2.2 evaluation) to be highlighted. The use of determinist methods (APOLLO2 code) together with Monte Carlo- type simulations (TRIPOLI4 code) enabled a depth analysis of the modelling approximations to be carried out. Furthermore, the sensitivity coefficient validation technique employed leads to a reliable assessment of the quality of the new basic nuclear data. In this instance, the adjustments proposed for certain isotope 177 Hf resonance parameters reduce, after error propagation, by 3 to 5 per cent the difference between experimental results and calculations related to this absorbent's efficiency. Beyond this particular application, the qualification methodology integrated in our calculation system should enable other basic sizing parameters to be treated (chemical / geometric data or other unexplored nuclear data) to make technological requirements less stringent. (author)

  13. Correlations between nuclear data and integral slab experiments: the case of hafnium

    International Nuclear Information System (INIS)

    Palau, J.M.

    1999-01-01

    The aim of this work was to evaluate how much integral slab experiments can both reduce discrepancies between experimental results and calculations, and improve the knowledge of hafnium isotopes neutronic parameters by an adapted sensitivity and uncertainty method. A statistical approach, based on the generalized least squares method and perturbation theory, has been incorporated into our calculation system in order to deduce microscopic cross-section adjustments from observed integral measurements on this particular 'mock-up' reactor.In this study it has been established that the correlations between integral parameters and hafnium capture cross-sections enable specific variations in the region of resolved resonances at the level of multigroup and punctual cross-sections recommended data (JEF-2.2 evaluation) to be highlighted. The use of determinist methods together with Monte Carlo- type simulations enabled a depth analysis of the modelling approximations to be carried out. Furthermore, the sensitivity coefficient validation technique employed leads to a reliable assessment of the quality of the new basic nuclear data. In this instance, the adjustments proposed for certain isotope 177 Hf resonance parameters reduce, after error propagation, by 3 to 5 per cent the difference between experimental results and calculations related to this absorbent's efficiency. Beyond this particular application, the qualification methodology integrated in our calculation system should enable other basic sizing parameters to be treated (chemical / geometric data or other unexplored nuclear data) to make technological requirements less stringent. (author)

  14. Investigation into magnetic correlations in cuprates by means of neutron scattering experiments

    International Nuclear Information System (INIS)

    Henggeler, W.

    1996-01-01

    This thesis shows the results of our investigation on cuprate materials containing rare earth ions. The main experimental tools were inelastic and elastic neutron scattering techniques. In some cases we also performed μSR, susceptibility and specific heat measurements. One aim was to learn more about the crystalline environment of the rare earth ions in these substances via the crystalline electric field (CEF) interaction. Furthermore, we investigated the correlations of the magnetic moments of these ions by a determination of the dispersion of the CEF excitations. The theory that is essential for the understanding of this work is outlined. The instruments on which the experiments have been performed are presented in the third chapter. In the fourth chapter we show the measurements of the CEF excitations of Ho 3+ in Y 0.99 Ho 0.01 Ba 2 Cu 3 O 6+x . The Ho ions represent ideal local probes to examine changes of the charge distribution in the copper oxide planes upon doping with oxygen. To prevent any influence of the Ho-Ho exchange interaction on the CEF excitations we performed the experiments on substances containing only one percent of Ho. Our results show that for all the intermediately doped compounds the charge distribution is very inhomogeneous. For all the highly doped samples we observe a line asymmetry for which several possible origins are discussed. In the fifth chapter we examine the Pr 3+ CEF excitations in the Pr 2-x Ce x CuO 4(-δ) (0≤x≤0.2)-substances. Our results show a coexistence of different environments of the Pr ions in all the doped compounds. We try to describe these inhomogeneities with the help of a model. We used the μSR-technique on some of these samples in order to learn more about the oxygen reduction process. Finally, we performed inelastic neutron scattering experiments on Pr 1.86 Ce 0.14 CuO 4 single crystal, which allowed a direct determination of the coupling constants between the magnetic moments of the Pr ions. (author

  15. Bone marrow involvement in diffuse large B-cell lymphoma: correlation between FDG-PET uptake and type of cellular infiltrate

    International Nuclear Information System (INIS)

    Paone, Gaetano; Itti, Emmanuel; Lin, Chieh; Meignan, Michel; Haioun, Corinne; Dupuis, Jehan; Gaulard, Philippe

    2009-01-01

    To assess, in patients with diffuse large B-cell lymphoma (DLBCL), whether the low sensitivity of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) for bone marrow assessment may be explained by histological characteristics of the cellular infiltrate. From a prospective cohort of 110 patients with newly diagnosed aggressive lymphoma, 21 patients with DLBCL had bone marrow involvement. Pretherapeutic FDG-PET images were interpreted visually and semiquantitatively, then correlated with the type of cellular infiltrate and known prognostic factors. Of these 21 patients, 7 (33%) had lymphoid infiltrates with a prominent component of large transformed lymphoid cells (concordant bone marrow involvement, CBMI) and 14 (67%) had lymphoid infiltrates composed of small cells (discordant bone marrow involvement, DBMI). Only 10 patients (48%) had abnormal bone marrow FDG uptake, 6 of the 7 with CBMI and 4 of the 14 with DBMI. Therefore, FDG-PET positivity in the bone marrow was significantly associated with CBMI, while FDG-PET negativity was associated with DBMI (Fisher's exact test, p=0.024). There were no significant differences in gender, age and overall survival between patients with CBMI and DBMI, while the international prognostic index was significantly higher in patients with CBMI. Our study suggests that in patients with DLBCL with bone marrow involvement bone marrow FDG uptake depends on two types of infiltrate, comprising small (DBMI) or large (CBMI) cells. This may explain the apparent low sensitivity of FDG-PET previously reported for detecting bone marrow involvement. (orig.)

  16. Overcoming correlation fluctuations in two-photon interference experiments with differently bright and independently blinking remote quantum emitters

    Science.gov (United States)

    Weber, Jonas H.; Kettler, Jan; Vural, Hüseyin; Müller, Markus; Maisch, Julian; Jetter, Michael; Portalupi, Simone L.; Michler, Peter

    2018-05-01

    As a fundamental building block for quantum computation and communication protocols, the correct verification of the two-photon interference (TPI) contrast between two independent quantum light sources is of utmost importance. Here, we experimentally demonstrate how frequently present blinking dynamics and changes in emitter brightness critically affect the Hong-Ou-Mandel-type (HOM) correlation histograms of remote TPI experiments measured via the commonly utilized setup configuration. We further exploit this qualitative and quantitative explanation of the observed correlation dynamics to establish an alternative interferometer configuration, which is overcoming the discussed temporal fluctuations, giving rise to an error-free determination of the remote TPI visibility. We prove full knowledge of the obtained correlation by reproducing the measured correlation statistics via Monte Carlo simulations. As an exemplary system, we make use of two pairs of remote semiconductor quantum dots; however, the same conclusions apply for TPI experiments with flying qubits from any kind of remote solid-state quantum emitters.

  17. Learning clinical skills in the simulation suite: the lived experiences of student nurses involved in peer teaching and peer assessment.

    Science.gov (United States)

    Ramm, Dianne; Thomson, Anna; Jackson, Andrew

    2015-06-01

    The benefits of peer teaching and assessment are well documented within nurse education literature. However, research to date has predominantly focused on the advantages and disadvantages for the inexperienced learner, with a dearth of knowledge relating to the perceptions of senior nursing students involved in teaching their peers. This study sought to investigate the student experience of taking part in a peer teaching and assessment initiative to include the perceptions of both first year nursing students and second/third year participants. Data were collected via open-ended questionnaires and analysed with qualitative 'Framework' analysis. This initiative received a generally positive response both from students being taught and also from those acting as facilitators. Perceived benefits included the social learning experience, development of teaching skills, self-awareness and the opportunity to communicate both good and bad news. Suggestions for improvement included additional time working in small groups, specific supplementary learning materials and the introduction of peer teaching and assessment into other areas of the Adult Nursing Programme. Peer teaching and assessment principles represent valuable strategies which can be utilised in nurse education to develop clinical skills and prepare nurses for real-life scenarios. Further research needs to investigate how to enhance the student learning experience and to fully exploit the potential for simulated experience to prepare students for their future role as registered nurses in clinical practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution′s experience

    Directory of Open Access Journals (Sweden)

    Ahmed K Alomari

    2016-01-01

    Full Text Available Background: Pancreatic masses may seldom represent a metastasis or secondary involvement by lymphoproliferative disorders. Recognition of this uncommon occurrence may help render an accurate diagnosis and avoid diagnostic pitfalls during endoscopic ultrasound-guided fine needle aspiration (EUS-FNA. In this study, we review our experience in diagnosing secondary tumors involving the pancreas. Materials and Methods: The electronic database of cytopathology archives was searched for cases of secondary tumors involving the pancreas at our institution and a total of 31 cases were identified. The corresponding clinical presentations, imaging study findings, cytological diagnoses, the results of ancillary studies, and surgical follow-up, if available, were reviewed. Results: Nineteen of the patients were male and 12 female, with a mean age of 66 years. Twenty-three patients (74% had a prior history of malignancy, with the latency ranging from 6 months to 19 years. The secondary tumors involving the pancreas included metastatic carcinoma (24 cases, metastatic sarcoma (3 cases, diffuse large B-cell lymphoma (2 cases, and plasma cell neoplasm (2 cases. The most common metastatic tumors were renal cell carcinoma (8 cases and lung carcinoma (7 cases. Correct diagnoses were rendered in 29 cases (94%. The remaining two cases were misclassified as primary pancreatic carcinoma. In both cases, the patients had no known history of malignancy, and no ancillary studies were performed. Conclusions: Secondary tumors involving the pancreas can be accurately diagnosed by EUS-FNA. Recognizing uncommon cytomorphologic features, knowing prior history of malignancy, and performing ancillary studies are the keys to improve diagnostic performance and avoid diagnostic pitfalls.

  19. Attitudes toward hiring applicants with mental illness and criminal justice involvement: the impact of education and experience.

    Science.gov (United States)

    Batastini, Ashley B; Bolanos, Angelea D; Morgan, Robert D

    2014-01-01

    Individuals with mental health diagnoses, as well as those involved in the criminal justice system, experience a number of barriers in the recovery and reintegration progress, including access to stable, prosocial employment opportunities. Employment for these populations is important for establishing financial security, reducing unstructured leisure time, increasing self-worth, and improving interpersonal skills. However, research has demonstrated that individuals with psychiatric and/or criminal backgrounds may experience stigmatizing attitudes from employers that impede their ability to find adequate work. This study aimed to evaluate stigmatizing beliefs toward hypothetical applicants who indicated a mental health history, a criminal history, or both, as well as the effectiveness of psychoeducation in reducing stigma. Participants consisted of 465 individuals recruited from a large university who completed a series of online questions about a given applicant. Results of this study varied somewhat across measures of employability, but were largely consistent with extant research suggesting that mental illness and criminal justice involvement serve as deterrents when making hiring decisions. Overall, psychoeducation appeared to reduce stigma for hiring decisions when the applicant presented with a criminal history. Unfortunately, similar findings were not revealed when applicants presented with a psychiatric or a psychiatric and criminal history. Implications and limitations of these findings are presented, along with suggestions for future research. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. The LPCTrap experiment: measurement of the β-ν angular correlation in 6He using a transparent Paul trap

    International Nuclear Information System (INIS)

    Lienard, E.; Ban, G.; Blieck, J.; Durand, D.; Duval, F.; Flechard, X.; Herbane, M.; Labalme, M.; Lemiere, Y.; Mauger, F.; Mery, A.; Naviliat-Cuncic, O.; Rodriguez, D.; Thomas, J. C.

    2006-01-01

    We report on the status of the LPCTrap experiment, devoted to measure the β-ν angular correlation in the pure Gamow-Teller decay of 6 He. This measurement is motivated by the search for the presence of tensor type contributions to the weak interaction. The 6 He ions are confined in a novel transparent Paul trap. The β particles and the recoil ions are detected in coincidence to deduce the angular correlation parameter. The commissioning run performed in 2005 has given the proof of principle of this experiment. Up to 10 5 coincidences were recorded during a second run in 2006.

  1. Pattern of mri brain abnormalities in rheumatic patients with neurological involvement: a tertiary care teaching hospital experience

    International Nuclear Information System (INIS)

    Parvez, K.; Arfaj, A.; Naseeb, F.; Daif, A.K.

    2015-01-01

    Objective: To explore the pattern of abnormalities seen on MRI in rheumatic patients with neurological manifestations and to interpret the findings in relation to clinical picture. Study Design: Descriptive study. Place and Duration of Study: Rheumatology unit, King Khalid University Hospital, Riyadh, Saudi Arabia from January 2013 to February 2014. Patients and Methods: We prospectively included rheumatic patients with neurological symptoms and signs. The clinical data were correlated with MRI findings by a team comprising of a rheumatologist, neurologist and neuro-radiologist. Data was analyzed using simple statistical analysis. Results: Fifty patients were recruited with a mean age of 36.4 ± 10.76 years (range 17-62). Among SLE patients with seizures, focal deficit and headache white matter hyperintensities were found in 9 (64.28%), 4 (50%), 4 (80%) patients respectively. Out of seven SLE patients with global dysfunction, 3 (42.85%) had brain atrophy and 2 (28.57%) normal MRI. In Behcet disease with focal deficit, 3 (75%) patients had white matter hyperintensities and 1 (25%) had brainstem involvement. In Behcet disease with headache, 2 (50%) had normal MRI, 1 (25%) brainstem hyper-intensities and 1 (25%) had subacute infarct. Two (66%) of three Primary APS patients had white matter hyperintensities while third (33%) had old infarct. Both patients of polyarteritisnodosa, had white matter hyperintensities. Out of two Wegener granulomatosis one had white matter hyperintensities and other had ischemic changes in optic nerves. The only one scleroderma patient had white matter hyperintensities. Conclusion: We found that white matter hyperintensities was the most common MRI abnormality in our study group which in most of the cases had poor clinical correlation. No distinct pattern of CNS involvement on MRI was observed in various rheumatic disorders. (author)

  2. Spin-density correlations in the dynamic spin-fluctuation theory: Comparison with polarized neutron scattering experiments

    Energy Technology Data Exchange (ETDEWEB)

    Melnikov, N.B., E-mail: melnikov@cs.msu.su [Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Reser, B.I., E-mail: reser@imp.uran.ru [Miheev Institute of Metal Physics, Ural Branch of Russian Academy of Sciences, Ekaterinburg 620990 (Russian Federation); Paradezhenko, G.V., E-mail: gparadezhenko@cs.msu.su [Lomonosov Moscow State University, Moscow 119991 (Russian Federation)

    2016-08-01

    To study the spin-density correlations in the ferromagnetic metals above the Curie temperature, we relate the spin correlator and neutron scattering cross-section. In the dynamic spin-fluctuation theory, we obtain explicit expressions for the effective and local magnetic moments and spatial spin-density correlator. Our theoretical results are demonstrated by the example of bcc Fe. The effective and local moments are found in good agreement with results of polarized neutron scattering experiment over a wide temperature range. The calculated short-range order is small (up to 4 Å) and slowly decreases with temperature.

  3. Event-related potential correlates of paranormal ideation and unusual experiences.

    Science.gov (United States)

    Sumich, Alex; Kumari, Veena; Gordon, Evian; Tunstall, Nigel; Brammer, Michael

    2008-01-01

    Separate dimensions of schizotypy have been differentially associated with electrophysiological measures of brain function, and further shown to be modified by sex/gender. We investigated event-related potential (ERP) correlates of two subdimensions of positive schizotypy, paranormal ideation (PI) and unusual experiences (UEs). Seventy-two individuals with no psychiatric diagnosis (men=36) completed self-report measures of UE and PI and performed an auditory oddball task. Average scores for N100, N200 and P300 amplitudes were calculated for left and right anterior, central and posterior electrode sites. Multiple linear regression was used to examine the relationships between the measures of schizotypy and ERPs across the entire sample, as well as separately according to sex. PI was inversely associated with P300 amplitude at left-central sites across the entire sample, and at right-anterior electrodes in women only. Right-anterior P300 and right-posterior N100 amplitudes were negatively associated with UE in women only. Across the entire sample, UE was negatively associated with left-central N100 amplitude, and positively associated with left-anterior N200 amplitude. These results provide support from electrophysiological measures for the fractionation of the positive dimension of schizotypy into subdimensions of PI and UE, and lend indirect support to dimensional or quasidimensional conceptions of psychosis. More specifically, they suggest that PI may be associated with alteration in contextual updating processes, and that UE may reflect altered sensory/early-attention (N100) mechanisms. The sex differences observed are consistent with those previously observed in individuals with schizophrenia.

  4. Pairwise NMR experiments for the determination of protein backbone dihedral angle Φ based on cross-correlated spin relaxation

    International Nuclear Information System (INIS)

    Takahashi, Hideo; Shimada, Ichio

    2007-01-01

    Novel cross-correlated spin relaxation (CCR) experiments are described, which measure pairwise CCR rates for obtaining peptide dihedral angles Φ. The experiments utilize intra-HNCA type coherence transfer to refocus 2-bond J NCα coupling evolution and generate the N (i)-C α (i) or C'(i-1)-C α (i) multiple quantum coherences which are required for measuring the desired CCR rates. The contribution from other coherences is also discussed and an appropriate setting of the evolution delays is presented. These CCR experiments were applied to 15 N- and 13 C-labeled human ubiquitin. The relevant CCR rates showed a high degree of correlation with the Φ angles observed in the X-ray structure. By utilizing these CCR experiments in combination with those previously established for obtaining dihedral angle Ψ, we can determine high resolution structures of peptides that bind weakly to large target molecules

  5. How to build institutionalization on students: a pilot experiment on a didactical design of addition and subtraction involving negative integers

    Science.gov (United States)

    Fuadiah, N. F.; Suryadi, D.; Turmudi

    2018-05-01

    This study focuses on the design of a didactical situation in addition and subtraction involving negative integers at the pilot experiment phase. As we know, negative numbers become an obstacle for students in solving problems related to them. This study aims to create a didactical design that can assist students in understanding the addition and subtraction. Another expected result in this way is that students are introduced to the characteristics of addition and subtraction of integers. The design was implemented on 32 seventh grade students in one of the classes in a junior secondary school as the pilot experiment. Learning activities were observed thoroughly including the students’ responses that emerged during the learning activities. The written documentation of the students was also used to support the analysis in the learning activities. The results of the analysis showed that this method could help the students perform a large number of integer operations that could not be done with a number line. The teacher’s support as a didactical potential contract was still needed to encourage institutionalization processes. The results of the design analysis used as the basis of the revision are expected to be implemented by the teacher in the teaching experiment.

  6. Chapter 5: Exponential experiments on natural uranium graphite moderated systems. II: Correlation of results with the method of Syrett (1961)

    International Nuclear Information System (INIS)

    Brown, G.; Moore, P.G.F.; Richmond, R.

    1963-01-01

    The results are given of exponential experiments on graphite moderated systems with fuel elements consisting of single rods and tubes of natural uranium metal. A correlation is given with the method of calculation proposed by Syrett (1961) and new consistent values of neutron yield and effective resonance integral are derived. (author)

  7. p-adic probability prediction of correlations between particles in the two-slit and neutron interferometry experiments

    International Nuclear Information System (INIS)

    Khrennikov, A.

    1998-01-01

    The Author start from Feynman's idea to use negative probabilities to describe the two-slit experiment and other quantum interference experiments. Formally by using negative probability distributions the Author can explain the results of the two-slit experiment on the basis of the pure corpuscular picture of quantum mechanics. However, negative probabilities are absurd objects in the framework of the standard Kolmogorov theory of probability. The Author present a large class of non-Kolmogorovean probability models where negative probabilities are well defined on the frequency basis. These are models with probabilities which belong to the so-called field of p-adic numbers. However, these models are characterized by correlations between trails. Therefore, the Author predict correlations between particles in interference experiments. In fact, the predictions are similar to the predictions of the so-called nonen ergodic interpretation of quantum mechanics, which was proposed by V. Buonomano. The Author propose the concrete experiments (in particular, in the framework of the neutron interferometry) to verify our predictions on the correlations

  8. [The experience of involvement of volunteers into maintenance of infection safety during period of implementation of mass activities].

    Science.gov (United States)

    Imamov, A A; Balabanova, L A; Zamalieva, M A

    2016-01-01

    The article presents experience of Rospotrebnadzor in the Republic of Tatarstan in the field of preventive medicine concerning training of volunteers on issues of infection safety with purpose of prevention of ictuses of infection diseases during mass activities with international participation in the period of XXVII World Summer Students Games. The model of hygienic training for volunteers provides two directions: training for volunteers ’ leaders on issues of infection safety and remote course for involved volunteers. During period of preparation for the Students Games-2013 hygienic training was organized for volunteers-leaders in the field of infection safety with following attestation. The modern training technologies were applied. The volunteers-leaders familiarized with groups of infection diseases including the most dangerous ones, investigated with expert algorithm of actions to be applied in case of suspicion on infection disease in gest or participant of the Games-2013 to secure one's health and health of immediate population. The active volunteers-leaders became trainers and coaches in the field of infection safety. The second stage of infection safety training organized by youth trainers' pool in number of 30 individuals the training technology "Equal trains equal" was applied for hygienic training of volunteers involved at epidemiologically significant objects (food objects, hotels, accompaniment of guests and sportsmen). The volunteers-leaders trained to infection safety 1400 volunteers. The format of electronic personal cabinet and remote course were selected as tools of post-training monitoring.

  9. Extracting the Beat: An Experience-dependent Complex Integration of Multisensory Information Involving Multiple Levels of the Nervous System

    Directory of Open Access Journals (Sweden)

    Laurel J. Trainor

    2009-04-01

    Full Text Available In a series of studies we have shown that movement (or vestibular stimulation that is synchronized to every second or every third beat of a metrically ambiguous rhythm pattern biases people to perceive the meter as a march or as a waltz, respectively. Riggle (this volume claims that we postulate an "innate", "specialized brain unit" for beat perception that is "directly" influenced by vestibular input. In fact, to the contrary, we argue that experience likely plays a large role in the development of rhythmic auditory-movement interactions, and that rhythmic processing in the brain is widely distributed and includes subcortical and cortical areas involved in sound processing and movement. Further, we argue that vestibular and auditory information are integrated at various subcortical and cortical levels along with input from other sensory modalities, and it is not clear which levels are most important for rhythm processing or, indeed, what a "direct" influence of vestibular input would mean. Finally, we argue that vestibular input to sound location mechanisms may be involved, but likely cannot explain the influence of vestibular input on the perception of auditory rhythm. This remains an empirical question for future research.

  10. Blame and guilt - a mixed methods study of obstetricians' and midwives' experiences and existential considerations after involvement in traumatic childbirth.

    Science.gov (United States)

    Schrøder, Katja; Jørgensen, Jan S; Lamont, Ronald F; Hvidt, Niels C

    2016-07-01

    When complications arise in the delivery room, midwives and obstetricians operate at the interface of life and death, and in rare cases the infant or the mother suffers severe and possibly fatal injuries related to the birth. This descriptive study investigated the numbers and proportions of obstetricians and midwives involved in such traumatic childbirth and explored their experiences with guilt, blame, shame and existential concerns. A mixed methods study comprising a national survey of Danish obstetricians and midwives and a qualitative interview study with selected survey participants. The response rate was 59% (1237/2098), of which 85% stated that they had been involved in a traumatic childbirth. We formed five categories during the comparative mixed methods analysis: the patient, clinical peers, official complaints, guilt, and existential considerations. Although blame from patients, peers or official authorities was feared (and sometimes experienced), the inner struggles with guilt and existential considerations were dominant. Feelings of guilt were reported by 36-49%, and 50% agreed that the traumatic childbirth had made them think more about the meaning of life. Sixty-five percent felt that they had become a better midwife or doctor due to the traumatic incident. The results of this large, exploratory study suggest that obstetricians and midwives struggle with issues of blame, guilt and existential concerns in the aftermath of a traumatic childbirth. © 2016 Nordic Federation of Societies of Obstetrics and Gynecology.

  11. Involvement of activated leukocytes in the regulation of plasma levels of acute phase proteins in microgravity simulation experiments

    Science.gov (United States)

    Larina, Olga; Bekker, Anna; Turin-Kuzmin, Alexey

    2016-07-01

    experiment. The effects obtained in this survey suggest the enhancement of the synthesis of active oxygen species by blood phagocytes at the initial stages of adaptation to immersion conditions. The gain of chemiluminescence signal correlated with maximal augment in APP concentrations registered in the course of 4-day immersion. Moreover, in the only case with zero effects in chemiluminescent reply stable APP levels were obtained. The data from functional studies performed with phagocytic cells in the experiment with dry immersion corroborate their implication in acute phase mechanisms participating in the adaptation to simulated microgravity conditions.

  12. Spatial correlations and probability density function of the phase difference in a developed speckle-field: numerical and natural experiments

    International Nuclear Information System (INIS)

    Mysina, N Yu; Maksimova, L A; Ryabukho, V P; Gorbatenko, B B

    2015-01-01

    Investigated are statistical properties of the phase difference of oscillations in speckle-fields at two points in the far-field diffraction region, with different shapes of the scatterer aperture. Statistical and spatial nonuniformity of the probability density function of the field phase difference is established. Numerical experiments show that, for the speckle-fields with an oscillating alternating-sign transverse correlation function, a significant nonuniformity of the probability density function of the phase difference in the correlation region of the field complex amplitude, with the most probable values 0 and p, is observed. A natural statistical interference experiment using Young diagrams has confirmed the results of numerical experiments. (laser applications and other topics in quantum electronics)

  13. Analysis of the impact of correlated benchmark experiments on the validation of codes for criticality safety analysis

    International Nuclear Information System (INIS)

    Bock, M.; Stuke, M.; Behler, M.

    2013-01-01

    The validation of a code for criticality safety analysis requires the recalculation of benchmark experiments. The selected benchmark experiments are chosen such that they have properties similar to the application case that has to be assessed. A common source of benchmark experiments is the 'International Handbook of Evaluated Criticality Safety Benchmark Experiments' (ICSBEP Handbook) compiled by the 'International Criticality Safety Benchmark Evaluation Project' (ICSBEP). In order to take full advantage of the information provided by the individual benchmark descriptions for the application case, the recommended procedure is to perform an uncertainty analysis. The latter is based on the uncertainties of experimental results included in most of the benchmark descriptions. They can be performed by means of the Monte Carlo sampling technique. The consideration of uncertainties is also being introduced in the supplementary sheet of DIN 25478 'Application of computer codes in the assessment of criticality safety'. However, for a correct treatment of uncertainties taking into account the individual uncertainties of the benchmark experiments is insufficient. In addition, correlations between benchmark experiments have to be handled correctly. For example, these correlations can arise due to different cases of a benchmark experiment sharing the same components like fuel pins or fissile solutions. Thus, manufacturing tolerances of these components (e.g. diameter of the fuel pellets) have to be considered in a consistent manner in all cases of the benchmark experiment. At the 2012 meeting of the Expert Group on 'Uncertainty Analysis for Criticality Safety Assessment' (UACSA) of the OECD/NEA a benchmark proposal was outlined that aimed for the determination of the impact on benchmark correlations on the estimation of the computational bias of the neutron multiplication factor (k eff ). The analysis presented here is based on this proposal. (orig.)

  14. Experience drives the development of movement-cognition correlations in a butterfly

    Directory of Open Access Journals (Sweden)

    Emilie eSnell-Rood

    2015-03-01

    Full Text Available Correlations between behavioral traits are widespread, but the developmental genetic architecture of such correlations is poorly characterized. Understanding the developmental mechanisms that lead to correlations between behaviors has implications for predicting how changing environments might alter the strength, direction and persistence of these associations. Here we test the idea that genetic variation in one behavioral trait can drive the development of traits related to a second behavior, resulting in correlations between them.. We focus on correlations between movement and aspects of cognition, in particular accuracy of decision making and neural investment. Such syndromes have been seen across a variety of systems, from insects to birds, but the direction of the correlation often varies. We use cabbage white butterflies as a system because they are easy to rear in large numbers and show ample genetic variation in both movement and learning, facilitating a split-sibling design. We test the prediction that variation in established proxies for movement at emergence will be correlated with the development of cognitive traits later in life (in siblings. Our results suggest that genotypes (full-sibling groups that emerge with more elongate wings explore their environment more rapidly. In addition, genotypes that emerge with relatively smaller thoraxes are more likely to learn to search for atypical host plants and subsequently develop larger brains and brain regions. Taken together, genotypes that invest less in flight are slower, better learners and develop larger brains. These data are consistent with the idea that movement can drive the development of other behavioral traits, resulting in the emergence of correlated behaviors.

  15. An adapted blockage factor correlation approach in wind tunnel experiments of a Savonius-style wind turbine

    International Nuclear Information System (INIS)

    Roy, Sukanta; Saha, Ujjwal K.

    2014-01-01

    Highlights: • Significance of the blockage correction in wind tunnel experiments of Savonius-style wind turbine. • Adaptation of blockage factor correlations under open type test sections for blockage ratio of 21.16%. • Effectiveness of adapted correlations for smaller blockage ratios (BRs) of 16% and 12.25%. • Estimate the magnitude of the blockage correction under various loading conditions for each BR. • Variation of blockage correction factor with respect to tip speed ratio and BR. - Abstract: An investigation into the blockage correction effects in wind tunnel experiments of a small-scale wind energy conversion system in an open type test section is carried out. The energy conversion system includes a Savonius-style wind turbine (SSWT) and a power measurement assembly. As the available correlations for the closed type test sections may not be appropriate for the open test section under dynamic loading conditions, new correlations are adapted for the blockage correction factors with free stream wind speed, turbine rotational speed and variable load applied to the turbine to quantify the energy conversion coefficients more precisely. These are obtained for a blockage ratio of 21.16% through a comparison of present experimental data with those of established experimental data under dynamic loading conditions. Further, the accuracy of the adapted correlations is substantiated into the experiments with smaller blockage ratios of 16% and 12.25%. The relationships of the tip speed ratios and blockage ratios with the blockage correction factor are also discussed. Using these correlations, this study provides evidence of increase of blockage correction in the range 1–10% with the increase of both tip speed ratio and blockage ratio. The results also indicate that for blockage ratios approaching 10 and tip speed ratios below 0.5, the blockage effects are almost negligible in the open type test sections

  16. Molybdenum(V, germanium(IV, aluminum(III and nickel(II adducts with ethyleneurea, ethylenethiourea and propyleneurea: some empirical correlations involving TG and IR data

    Directory of Open Access Journals (Sweden)

    ROBSON F. DE FARIAS

    2006-03-01

    Full Text Available The adducts MoCl5·2eu, MoCl5·2pu, GeCl4·2etu, AlCl3·2pu, AlCl3·3pu, NiCl2·2etu and NiCl2·4etu (eu = ethyleneurea, etu = ethylenethiourea and pu =propyleneurea were synthesized and characterized by elemental analysis (C, H, N, infrared spectroscopy (IR and thermogravimetry (TG. IR Results show that eu and pu coordinate through oxygen, whereas etu coordinates through nitrogen. For all investigated adducts, a single mass loss step associated with the release of ligand molecules is observed. Empirical correlations involving TG and IR data are established.

  17. Selected results on strong and coulomb-induced correlations from the STAR experiment

    International Nuclear Information System (INIS)

    Sumbera, M.

    2007-01-01

    Using recent high-statistics STAR data from Au + Au and Cu + Cu collisions at full RHIC energy I discuss strong and Coulomb-induced final state interaction effects on identical (pi-pi) and non-identical (pi-XI) particle correlations. Analysis of pi-XI correlations reveals the strong and Coulomb-induced FSI effects, allowing for the first time to estimate spatial extension of pi and XI sources and the average shift between them. Source imaging techniques provide clean separation of details of the source function and are applied to the one-dimensional relative momentum correlation function of identical pions. For low momentum pions, and/or non-central collisions, a large departure from a single-Gaussian shape is observed. (author)

  18. The Discourse of Parent Involvement in Special Education: A Critical Analysis Linking Policy Documents to the Experiences of Mothers

    Science.gov (United States)

    Lai, Yuan; Vadeboncoeur, Jennifer A.

    2013-01-01

    Parent involvement is acknowledged as a crucial aspect of the education of students with special needs. However, the discourse of parent involvement represents parent involvement in limited ways, thereby controlling how and the extent to which parents can be involved in the education of their children. In this article, critical discourse analysis…

  19. Pulmonary involvement in rheumatoid arthritis. HRCT findings as their correlation with the clinical data, with function tests and with bronchoalveolar lavage

    International Nuclear Information System (INIS)

    Dosda, R.; Domingo, M. L.; Marti-Bonmati, L.; Rodrigo, C.; Torregrosa, A.

    1999-01-01

    To assess the high-resolution computed tomography (HRCT) findings in rheumatoid arthritis and their correlation with clinical data, respiratory function tests (RFT) and bronchoalveolar lavage (BAL). Nineteen patients were studied by inspiratory and expiratory HRCT scan and clinical examination: 17 also underwent RFT and 12 were also subjected to BAL. The χ''2 test was used to analyze the correlation among the clinical data, RAFT, BAL and the HRCT images. Six patients had no respiratory symptoms and seven were smokers. The most common findings was bronchiectasis (37%), followed by nodules (26%), ground glass (26%), non septal lines (21%), septal lines (16%), emphysema (21%), lymph nodes (21%), pleural changes (16%), pericardial changes (11%) and enlarged pulmonary artery (5%). All the patients presented a mosaic pattern on expiration. The RFT disclosed obstructive lung disease in 74% of cases, normal in 41% and restrictive disease in 12%. BAL was normal in 50% of the patients, containing a high neutrophil count in 42% and high lymphocyte count in 8%. Only the correlations between smoking and emphysema and between the results of RFT and bronchiectasis, septal and non septal lines, ground glass and honey combing were found to be statistically significant. HRCT detects pulmonary involvement in rheumatoid arthritis even in the absence of respiratory symptoms. The most common finding is bronchiectasis. Air trapping is always present in expiration, obstructive lung disease being the most common finding in RFT. The only significant associations were those between smoking and emphysema and between the results of RFT and the HRCT findings, as indicated by the high incidence of restrictive lung disease in these patients. (Author) 10 refs

  20. Benefits, challenges, and best practices for involving audiences in the development of interactive coastal risk communication tools: Professional communicators' experiences

    Science.gov (United States)

    Stephens, S. H.; DeLorme, D.

    2017-12-01

    To make scientific information useful and usable to audiences, communicators must understand audience needs, expectations, and future applications. This presentation synthesizes benefits, challenges, and best practices resulting from a qualitative social science interview study of nine professionals on their experiences developing interactive visualization tools for communicating about coastal environmental risks. Online interactive risk visualization tools, such as flooding maps, are used to provide scientific information about the impacts of coastal hazards. These tools have a wide range of audiences and purposes, including time-sensitive emergency communication, infrastructure and natural resource planning, and simply starting a community conversation about risks. Thus, the science, purposes, and audiences of these tools require a multifaceted communication strategy. In order to make these tools useable and accepted by their audiences, many professional development teams solicit target end-user input or incorporate formal user-centered design into the development process. This presentation will share results of seven interviews with developers of U.S. interactive coastal risk communication tools, ranging from state-level to international in scope. Specific techniques and procedures for audience input that were used in these projects will be discussed, including ad-hoc conversations with users, iterative usability testing with project stakeholder groups, and other participatory mechanisms. The presentation will then focus on benefits, challenges, and recommendations for best practice that the interviewees disclosed about including audiences in their development projects. Presentation attendees will gain an understanding of different procedures and techniques that professionals employ to involve end-users in risk tool development projects, as well as important considerations and recommendations for effectively involving audiences in science communication design.

  1. Investigating daytime effects of correlated colour temperature on experiences, performance, and arousal

    NARCIS (Netherlands)

    Smolders, K.C.H.J.; de Kort, Y.A.W.

    Research in the late evening and at night has shown that acute activating effects of light are particularly sensitive to short-wavelength light. Yet, findings on such effects during daytime are still inconclusive. This study (N=39) investigated effects of correlated colour temperature (CCT; 2700 K

  2. Ground-Laboratory to In-Space Atomic Oxygen Correlation for the Polymer Erosion and Contamination Experiment (PEACE) Polymers

    Science.gov (United States)

    Stambler, Arielle H.; Inoshita, Karen E.; Roberts, Lily M.; Barbagallo, Claire E.; deGroh, Kim K.; Banks, Bruce A.

    2011-01-01

    The Materials International Space Station Experiment 2 (MISSE 2) Polymer Erosion and Contamination Experiment (PEACE) polymers were exposed to the environment of low Earth orbit (LEO) for 3.95 years from 2001 to 2005. There were 41 different PEACE polymers, which were flown on the exterior of the International Space Station (ISS) in order to determine their atomic oxygen erosion yields. In LEO, atomic oxygen is an environmental durability threat, particularly for long duration mission exposures. Although spaceflight experiments, such as the MISSE 2 PEACE experiment, are ideal for determining LEO environmental durability of spacecraft materials, ground-laboratory testing is often relied upon for durability evaluation and prediction. Unfortunately, significant differences exist between LEO atomic oxygen exposure and atomic oxygen exposure in ground-laboratory facilities. These differences include variations in species, energies, thermal exposures and radiation exposures, all of which may result in different reactions and erosion rates. In an effort to improve the accuracy of ground-based durability testing, ground-laboratory to in-space atomic oxygen correlation experiments have been conducted. In these tests, the atomic oxygen erosion yields of the PEACE polymers were determined relative to Kapton H using a radio-frequency (RF) plasma asher (operated on air). The asher erosion yields were compared to the MISSE 2 PEACE erosion yields to determine the correlation between erosion rates in the two environments. This paper provides a summary of the MISSE 2 PEACE experiment; it reviews the specific polymers tested as well as the techniques used to determine erosion yield in the asher, and it provides a correlation between the space and ground laboratory erosion yield values. Using the PEACE polymers asher to in-space erosion yield ratios will allow more accurate in-space materials performance predictions to be made based on plasma asher durability evaluation.

  3. Correlates and Consequences of Parent–Teen Incongruence in Reports of Teens’ Sexual Experience

    Science.gov (United States)

    Mollborn, Stefanie; Everett, Bethany

    2011-01-01

    Using the National Longitudinal Study of Adolescent Health, factors associated with incongruence between parents’ and adolescents’ reports of teens’ sexual experience were investigated, and the consequences of inaccurate parental knowledge for adolescents’ subsequent sexual behaviors were explored. Most parents of virgins accurately reported teens’ lack of experience, but most parents of teens who had had sex provided inaccurate reports. Binary logistic regression analyses showed that many adolescent-, parent-, and family-level factors predicted the accuracy of parents’ reports. Parents’ accurate knowledge of their teens’ sexual experience was not found to be consistently beneficial for teens’ subsequent sexual outcomes. Rather, parents’ expectations about teens’ sexual experience created a self-fulfilling prophecy, with teens’ subsequent sexual outcomes conforming to parents’ expectations. These findings suggest that research on parent–teen communication about sex needs to consider the expectations being expressed, as well as the information being exchanged. PMID:19431037

  4. Correlates and consequences of parent-teen incongruence in reports of teens' sexual experience.

    Science.gov (United States)

    Mollborn, Stefanie; Everett, Bethany

    2010-07-01

    Using the National Longitudinal Study of Adolescent Health, factors associated with incongruence between parents' and adolescents' reports of teens' sexual experience were investigated, and the consequences of inaccurate parental knowledge for adolescents' subsequent sexual behaviors were explored. Most parents of virgins accurately reported teens' lack of experience, but most parents of teens who had had sex provided inaccurate reports. Binary logistic regression analyses showed that many adolescent-, parent-, and family-level factors predicted the accuracy of parents' reports. Parents' accurate knowledge of their teens' sexual experience was not found to be consistently beneficial for teens' subsequent sexual outcomes. Rather, parents' expectations about teens' sexual experience created a self-fulfilling prophecy, with teens' subsequent sexual outcomes conforming to parents' expectations. These findings suggest that research on parent-teen communication about sex needs to consider the expectations being expressed, as well as the information being exchanged.

  5. PROTON - LAMBDA CORRELATIONS IN AU-AU COLLISIONS AT SQUARE ROOT NN = 200 GEV FROM THE STAR EXPERIMENT.

    Energy Technology Data Exchange (ETDEWEB)

    RENAULT,G.; (THE STAR COLLABORATION)

    2004-03-15

    The space-time evolution of the source of particles formed in the collision of nuclei can be studied through particle correlations. The STAR experiment is dedicated to study ultra-relativistic heavy ions collisions and allows to measure non-identical strange particle correlations. The source size can be extracted by studying p - {Lambda}, {bar p} - {bar {Lambda}}, {bar p} - {Lambda} and p - {bar {Lambda}} correlation functions. Strong interaction potential has been studied for these systems using an analytical model. Final State Interaction (FSI) parameters have been determined and has shown a significant annihilation process present in {bar p} - {Lambda} and p - {bar {Lambda}} systems not present in p - {Lambda} and {bar p} - {bar {Lambda}}.

  6. Blame and guilt - a mixed methods study of obstetricians' and midwives' experiences and existential considerations after involvement in traumatic childbirth

    DEFF Research Database (Denmark)

    Schrøder, Katja; Jørgensen, Jan S; Lamont, Ronald F

    2016-01-01

    INTRODUCTION: When complications arise in the delivery room, midwives and obstetricians operate at the interface of life and death, and in rare cases the infant or the mother suffers severe and possibly fatal injuries related to the birth. This descriptive study investigated the numbers and propo......INTRODUCTION: When complications arise in the delivery room, midwives and obstetricians operate at the interface of life and death, and in rare cases the infant or the mother suffers severe and possibly fatal injuries related to the birth. This descriptive study investigated the numbers...... and proportions of obstetricians and midwives involved in such traumatic childbirth and explored their experiences with guilt, blame, shame and existential concerns. MATERIAL AND METHODS: A mixed methods study comprising a national survey of Danish obstetricians and midwives and a qualitative interview study...... the meaning of life. Sixty-five percent felt that they had become a better midwife or doctor due to the traumatic incident. CONCLUSIONS: The results of this large, exploratory study suggest that obstetricians and midwives struggle with issues of blame, guilt and existential concerns in the aftermath...

  7. [Implementation of telemedicine programs in Spain: experience of the main actors involved in the decision-making process].

    Science.gov (United States)

    Mahtani Chugani, Vinita; Martín Fernández, Roberto Luis; Soto Pedre, Enrique; Yanes López, Virginia; Serrano Aguilar, Pedro

    2009-01-01

    To identify the main benefits and risks related to the implementation of telemedicine programs in Spain, based on the experience of the actors influencing the decision-making process. We performed a qualitative study based on audiotaped semi-structured telephone interviews. Eleven interviews were carried out, and the perspective of four physicians, three administrators, two researchers and two telecommunications industry workers were included. Theoretical sampling was used and thematic inductive analysis was performed. The following factors were identified as necessary to successfully resolve problems by using telemedicine programs: the commitment of the persons involved, technological aspects, economic and institutional support, acceptance by healthcare professionals and patients, the existence of protocols adjusted to the context, the need for information and training prior to the development of telemedicine programs, a forward-looking approach, routine use and full acceptance of telemedicine programs in the organization, and the need to defend equity for professionals and users. Successfully developing a telemedicine program requires a favorable environment in which risk can be foreseen. The main key element seems to be the human factor. The factors identified in this study should be considered when developing strategies to increase the chances of success of telemedicine programs in Spain.

  8. Rehme correlation for spacer pressure drop compared to XT-ADS rod bundle simulations and water experiment

    International Nuclear Information System (INIS)

    Batta, A.; Class, A.; Litfin, K.; Wetzel, T.

    2011-01-01

    The Rehme correlation is the most common formula to estimate the pressure drop of spacers in the design phase of new bundle geometries. It is based on considerations of momentum losses and takes into account the obstruction of the flow cross section but it ignores the geometric details of the spacer design. Within the framework of accelerator driven sub-critical reactor systems (ADS), heavy-liquid-metal (HLM) cooled fuel assemblies are considered. At the KArlsruhe Liquid metal LAboratory (KALLA) of the Karlsruhe Institute of Technology a series of experiments to quantify both pressure losses and heat transfer in HLM-cooled rod bundles are performed. The present study compares simulation results obtained with the commercial CFD code Star-CCM to experiments and the Rehme correlation. It can be shown that the Rehme correlation, simulations and experiments all yield similar trends, but quantitative predictions can only be delivered by the CFD which takes into account the full geometric details of the spacer geometry. (orig.)

  9. Good Old Gamers, Good Drivers: Results from a correlational experiment among older drivers

    Directory of Open Access Journals (Sweden)

    Suchada Vichitvanichphong

    2016-03-01

    Full Text Available In many situations, driving is essential for senior citizens to maintain their independent lifestyle. A systematic literature review was conducted that summarized the age-related physical, visual and cognitive functional declines and their associated risk to driving. Based on these findings, we explored whether the skills required in playing Xbox Kinect video games were correlated with measures of driving performance among older drivers. Fifty-two participants, 65 years of age or older (Mean = 72; SD = 3.84; range 65 – 85 years; 29 males who have access to a car and drive frequently were invited to play Just dance, Table Tennis (ping pong, Bowling, and Dr Kawashima’s Brain Training Exercises on an Xbox Kinect 360. Participants also completed a 25-minute on-road driving task along a predetermined route to assess and identify critical driving errors using a similar instrument as that used by a driving license tester. Bivariate correlation examined the relationship between game scores and these objective driving skills. There was a significant correlation between the Xbox Kinect video games and on-road driving scores (r = 0.861, p <0.001, indicating that ‘good gamers are good drivers’. This was correlation was significant for the males (r = 0.864, p <0.001 as well as for the females (r = 0.878, p <0.001. We suggest that performance on Xbox games may be a suitable, cost-effective and less-risky indicator of on-road driving skills for older drivers, particularly in jurisdictions in which mandatory testing of older citizens has been introduced or is being considered as a requirement in the driver licensing process.

  10. Women Exiting Street-Based Sex Work: Correlations between Ethno-Racial Identity, Number of Children, and Violent Experiences.

    Science.gov (United States)

    Hankel, Jennifer; Dewey, Susan; Martinez, Nina

    2016-01-01

    Through this article the authors examine data collected from 126 women seeking services at a transitional housing facility, primarily for women leaving street-based prostitution. Descriptive statistics on the women's ethno-racial identity, numbers of children, and experiences with violence are presented and analyzed to determine correlations and implications for social service providers working with this unique population of women. Nearly half of respondents are women of color, a majority have given birth to at least one child, and more than half are in a non-commercial intimate partnership, with a significant number reporting extensive experiences with violent trauma and abuse. Results indicate statistically significant differences in women's ethno-racial self-identification and their experiences of sex work and violence, as well as their marital status. Most notably, African-American and Hispanic women face the greatest and most diverse forms of intimate partner violence and negative sex industry experiences, with African-Americans more likely to engage in sex work as minors, be sexually abused as children, work for a pimp, and face physical assault and instances of sex trafficking. Results also support existing research showing correlations between traumatic childhood events and adult substance abuse, sexual assault, and other negative outcomes.

  11. Perturbed angular correlation experiments on the rehydration of ZnTiF6

    International Nuclear Information System (INIS)

    Ceolin, M.; Taylor, M.A.; Martinez, J.A.

    1997-01-01

    The rehydration process at room temperature, after the dehydration of ZnTiF 6 . 6H 2 O to ZnTiF 6 , was studied by means of the Time Differential Perturbed Angular Correlations technique.The time evolution of the hyperfine parameters related to the hyperfine interaction observed is reported and interpreted in terms of a simple model for the growth of the phases.In the framework of this model, the time evolution of the relative fractions of each interaction is interpreted

  12. Plan of measurement experiment of correlation between ion beam and plasma

    Energy Technology Data Exchange (ETDEWEB)

    Oguri, Yoshiyuki; Abe, Satoru; Sakumi, Akira; Okazaki, Hisashi; Watanabe, Takeshi [Tokyo Inst. of Tech. (Japan). Research Lab. for Nuclear Reactors

    1996-12-01

    The Research Laboratory, for Nuclear Reactors, Tokyo Institute of Technology has conducted experimental study on accelerating structure and beam behavior of high intensity heavy ion accelerator for a beam driver and its computer simulation study as a circle of fundamental study of the heavy ion inertial nuclear fusion. From last fiscal year, a preliminary study for measuring the correlation between beam and plasma using low speed heavy ion beam from 1.7 MV tandem accelerator was begun. As a result, a possibility of forming a plasma target with above 10 (exp 17)/cu cm in free electron density and about 100 ns in life possible to supply to measurement of the correlation between beam and plasma was obtained by formation of laser plasma target and development of diagnostic measurement system. According to the preliminary calculation, it is expected to be larger charging state of ion passing through plasma than that in normal temperature target, and stoppability is presumed to increase largely and to apply to electron stopper for accelerator. And, a plan of time resolution measurement of energy loss of beam passed through plasma target using magnetic field type spectrometer and high speed plastic scintillator is also preceeding. (G.K.)

  13. NRC test results and operations experience provide insights for a new gate valve stem force correlation

    International Nuclear Information System (INIS)

    Watkins, John C.; Steele, Robert Jr.; DeWall, Kevin G.; Weidenhamer, G.H.; Rothberg, O.O.

    1994-01-01

    This paper presents the results of testing sponsored by the NRC to assess valve and motor operator performance under varying pressure and fluid conditions. This effort included an examination of the methods used by the industry to predict the required stem force of a valve, and research to provide guidelines for the extrapolation of in situ test results to design basis conditions.Years ago, when most of these valves were originally installed, the industry used a set of equations to determine analytically that the valves' motor-operators were large enough and the control switches were set high enough to close the valves at their design basis conditions. Our research has identified several inconsistencies with the industry's existing gate valve stem force equation and has challenged the overly simplistic assumptions inherent in its use. This paper discusses the development of the INEL correlation, which serves as the basis for a method to bound the stem force necessary to close flexwedge gate valves whose operational characteristics have been shown to be predictable. As utilities undertake to provide assurance of their valves' operability, this ability to predict analytically the required stem force is especially important for valves that cannot be tested at design basis conditions. For such valves, the results of tests conducted at less severe conditions can be used with the INEL correlation to make the necessary prediction. ((orig.))

  14. Detection of C',Cα correlations in proteins using a new time- and sensitivity-optimal experiment

    International Nuclear Information System (INIS)

    Lee, Donghan; Voegeli, Beat; Pervushin, Konstantin

    2005-01-01

    Sensitivity- and time-optimal experiment, called COCAINE (CO-CA In- and aNtiphase spectra with sensitivity Enhancement), is proposed to correlate chemical shifts of 13 C' and 13 C α spins in proteins. A comparison of the sensitivity and duration of the experiment with the corresponding theoretical unitary bounds shows that the COCAINE experiment achieves maximum possible transfer efficiency in the shortest possible time, and in this sense the sequence is optimal. Compared to the standard HSQC, the COCAINE experiment delivers a 2.7-fold gain in sensitivity. This newly proposed experiment can be used for assignment of backbone resonances in large deuterated proteins effectively bridging 13 C' and 13 C α resonances in adjacent amino acids. Due to the spin-state selection employed, the COCAINE experiment can also be used for efficient measurements of one-bond couplings (e.g. scalar and residual dipolar couplings) in any two-spin system (e.g. the N/H in the backbone of protein)

  15. Correlation of the antimicrobial activity of salicylaldehydes with broadening of the NMR signal of the hydroxyl proton. Possible involvement of proton exchange processes in the antimicrobial activity.

    Science.gov (United States)

    Elo, Hannu; Kuure, Matti; Pelttari, Eila

    2015-03-06

    Certain substituted salicylaldehydes are potent antibacterial and antifungal agents and some of them merit consideration as potential chemotherapeutic agents against Candida infections, but their mechanism of action has remained obscure. We report here a distinct correlation between broadening of the NMR signal of the hydroxyl proton of salicylaldehydes and their activity against several types of bacteria and fungi. When proton NMR spectra of the compounds were determined using hexadeuterodimethylsulfoxide as solvent and the height of the OH proton signal was measured, using the signal of the aldehyde proton as an internal standard, it was discovered that a prerequisite of potent antimicrobial activity is that the proton signal is either unobservable or relatively very low, i.e. that it is extremely broadened. Thus, none of the congeners whose OH proton signal was high were potent antimicrobial agents. Some congeners that gave a very low OH signal were, however, essentially inactive against the microbes, indicating that although drastic broadening of the OH signal appears to be a prerequisite, also other (so far unknown) factors are needed for high antimicrobial activity. Because broadening of the hydroxyl proton signal is related to the speed of the proton exchange process(es) involving that proton, proton exchange may be involved in the mechanism of action of the compounds. Further studies are needed to analyze the relative importance of different factors (such as electronic effects, strength of the internal hydrogen bond, co-planarity of the ring and the formyl group) that determine the rates of those processes. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  16. Manifestations of classical physics in the quantum evolution of correlated spin states in pulsed NMR experiments.

    Science.gov (United States)

    Ligare, Martin

    2016-05-01

    Multiple-pulse NMR experiments are a powerful tool for the investigation of molecules with coupled nuclear spins. The product operator formalism provides a way to understand the quantum evolution of an ensemble of weakly coupled spins in such experiments using some of the more intuitive concepts of classical physics and semi-classical vector representations. In this paper I present a new way in which to interpret the quantum evolution of an ensemble of spins. I recast the quantum problem in terms of mixtures of pure states of two spins whose expectation values evolve identically to those of classical moments. Pictorial representations of these classically evolving states provide a way to calculate the time evolution of ensembles of weakly coupled spins without the full machinery of quantum mechanics, offering insight to anyone who understands precession of magnetic moments in magnetic fields.

  17. Protective Behaviour of Citizens to Transport Accidents Involving Hazardous Materials: A Discrete Choice Experiment Applied to Populated Areas nearby Waterways.

    Directory of Open Access Journals (Sweden)

    Esther W de Bekker-Grob

    Full Text Available To improve the information for and preparation of citizens at risk to hazardous material transport accidents, a first important step is to determine how different characteristics of hazardous material transport accidents will influence citizens' protective behaviour. However, quantitative studies investigating citizens' protective behaviour in case of hazardous material transport accidents are scarce.A discrete choice experiment was conducted among subjects (19-64 years living in the direct vicinity of a large waterway. Scenarios were described by three transport accident characteristics: odour perception, smoke/vapour perception, and the proportion of people in the environment that were leaving at their own discretion. Subjects were asked to consider each scenario as realistic and to choose the alternative that was most appealing to them: staying, seeking shelter, or escaping. A panel error component model was used to quantify how different transport accident characteristics influenced subjects' protective behaviour.The response was 44% (881/1,994. The predicted probability that a subject would stay ranged from 1% in case of a severe looking accident till 62% in case of a mild looking accident. All three transport accident characteristics proved to influence protective behaviour. Particularly a perception of strong ammonia or mercaptan odours and visible smoke/vapour close to citizens had the strongest positive influence on escaping. In general, 'escaping' was more preferred than 'seeking shelter', although stated preference heterogeneity among subjects for these protective behaviour options was substantial. Males were less willing to seek shelter than females, whereas elderly people were more willing to escape than younger people.Various characteristics of transport accident involving hazardous materials influence subjects' protective behaviour. The preference heterogeneity shows that information needs to be targeted differently depending on

  18. Power1D: a Python toolbox for numerical power estimates in experiments involving one-dimensional continua

    Directory of Open Access Journals (Sweden)

    Todd C. Pataky

    2017-07-01

    Full Text Available The unit of experimental measurement in a variety of scientific applications is the one-dimensional (1D continuum: a dependent variable whose value is measured repeatedly, often at regular intervals, in time or space. A variety of software packages exist for computing continuum-level descriptive statistics and also for conducting continuum-level hypothesis testing, but very few offer power computing capabilities, where ‘power’ is the probability that an experiment will detect a true continuum signal given experimental noise. Moreover, no software package yet exists for arbitrary continuum-level signal/noise modeling. This paper describes a package called power1d which implements (a two analytical 1D power solutions based on random field theory (RFT and (b a high-level framework for computational power analysis using arbitrary continuum-level signal/noise modeling. First power1d’s two RFT-based analytical solutions are numerically validated using its random continuum generators. Second arbitrary signal/noise modeling is demonstrated to show how power1d can be used for flexible modeling well beyond the assumptions of RFT-based analytical solutions. Its computational demands are non-excessive, requiring on the order of only 30 s to execute on standard desktop computers, but with approximate solutions available much more rapidly. Its broad signal/noise modeling capabilities along with relatively rapid computations imply that power1d may be a useful tool for guiding experimentation involving multiple measurements of similar 1D continua, and in particular to ensure that an adequate number of measurements is made to detect assumed continuum signals.

  19. Exploring the Correlates to Depression in Elder Abuse Victims: Abusive Experience or Individual Characteristics?

    Science.gov (United States)

    Santos, Ana João; Nunes, Baltazar; Kislaya, Irina; Gil, Ana Paula; Ribeiro, Oscar

    2017-09-01

    Depression and depressive symptoms have been studied both as risk factors and consequences of elder abuse, even though the most common cross-sectional design of the studies does not allow inferring cause or consequence relationships. This study estimates the proportion of older adults who screened positive for depressive symptoms among those self-reporting elder abuse and examines whether individual characteristics and/or abusive experience aspects are associated with self-reported depressive symptoms. Participants were 510 older adults self-reporting experiences of abuse in family setting enrolled in the cross-sectional victims' survey of the Aging and Violence Study. Depressive symptoms were assessed through the abbreviated version of the Geriatric Depression Scale (GDS-5). Poisson regression was used to determine the prevalence ratio (PR) of screening depressive symptoms according to individual and abusive experience covariates: sex, age group, cohabitation, perceived social support, chronic diseases, functional status, violence type, perpetrator, and number of conducts. Women (PR = 1.18, 95% confidence interval [CI] = [1.04, 1.35]) individuals perceiving low social support level (PR = 1.36, 95% CI = [1.16, 1.60]) and with long-term illness (PR = 1.17, 95% CI = [1.02, 1.33]) were found to be associated with increased risk for screening depressive symptoms. In regard to abusive experience, only the number of abusive conducts increased the PR (PR = 1.07, 95% CI = [1.05, 1.09]). Routine screening for elder abuse should include psychological well-being assessment. Interventions toward risk alleviation for both mental health problems and elder abuse should target women perceiving low social support level and with long-term illness.

  20. Neighborhood Walking and Social Capital: The Correlation between Walking Experience and Individual Perception of Social Capital

    Directory of Open Access Journals (Sweden)

    Heechul Kim

    2017-04-01

    Full Text Available The purpose of this study was to analyze the relationship between people’s actual walking experience and their social capital levels in order to examine the possibility of restoring weakened social functions of streets and public spaces in a walking-friendly urban environment. Based on the survey data of 591 residents of Seoul, we empirically analyzed the relationship between walking experience for various purposes and individual perceptions of social capital using one-way ANOVA and OLS regression models. As a result of the analysis, we found that the levels of neighborly trust and networking of people who experienced leisure walking were higher than those of people who did not, while there was no difference in the level of social capital according to walking experiences for other purposes. This result is significant in that it shows the basis for the restoration of the social function of neighborhoods through social capital formation of people as an effect of walking. Hence, it is important to create a walking environment that supports leisure activities.

  1. Correlation of microdosimetric measurements with relative biological effectiveness from clinical experience for two neutron therapy beams

    International Nuclear Information System (INIS)

    Stinchcomb, T.G.; Kuchnir, F.T.; Myrianthopoulos, L.C.; Horton, J.L. Jr.; Roberts, W.K.

    1986-01-01

    Microdosimetric measurements were made for the neutron therapy beams at the University of Chicago and at the Cleveland Clinic with the same geometry and phantom material using the same tissue-equivalent spherical proportional counter and standard techniques. The energy deposition spectra (dose distributions in lineal energy) are compared for these beams and for their scattered components (direct beam blocked). The model of dual radiation action (DRA) of Kellerer and Rossi is employed to interpret these data in terms of biological effectiveness over this limited range of radiation qualities. The site-diameter parameter of the DRA theory is determined for the Cleveland beam by setting the biological effectiveness (relative to 60 Co gamma radiation) equal to the relative biological effectiveness value deduced from radiobiology experiments and clinical experience. The resulting value of this site-diameter parameter is then used to predict the biological effectiveness of the Chicago beam. The prediction agrees with the value deduced from radiobiology and clinical experience. The biological effectiveness of the scattered components of both beams is also estimated using the model

  2. Flashing liquid jets and two-phase droplet dispersion I. Experiments for derivation of droplet atomisation correlations.

    Science.gov (United States)

    Cleary, Vincent; Bowen, Phil; Witlox, Henk

    2007-04-11

    The large-scale release of a liquid contained at upstream conditions above its local atmospheric boiling point is a scenario often given consideration in process industry risk analysis. Current-hazard quantification software often employs simplistic equilibrium two-phase approaches. Scaled water experiments have been carried out measuring droplet velocity and droplet size distributions for a range of exit orifice aspect ratios (L/d) and conditions representing low to high superheat. 2D Phase-Doppler Anemometry has been utilised to characterise droplet kinematics and spray quality. Droplet size correlations have been developed for non-flashing, the transition between non-flashing and flashing, and fully flashing jets. Using high-speed shadowography, transition between regimes is defined in terms of criteria identified in the external flow structure. An overview companion paper provides a wider overview of the problem and reports implementation of these correlations into consequence models and subsequent validation. The fluid utilised throughout is water, hence droplet correlations are developed in non-dimensional form to allow extrapolation to other fluids through similarity scaling, although verification of model performance for other fluids is required in future studies. Data is reduced via non-dimensionalisation in terms of the Weber number and Jakob number, essentially representing the fluid mechanics and thermodynamics of the system, respectively. A droplet-size distribution correlation has also been developed, conveniently presented as a volume undersize distribution based on the Rosin-Rammler distribution. Separate correlations are provided for sub-cooled mechanical break-up and fully flashing jets. This form of correlation facilitates rapid estimates of likely mass rainout quantities, as well as full distribution information for more rigorous two-phase thermodynamic modelling in the future.

  3. Correlation between donor age and organs transplanted per donor: our experience in Japan.

    Science.gov (United States)

    Ashikari, J; Omiya, K; Konaka, S; Nomoto, K

    2014-05-01

    The shortage of available organs for transplantation is a worldwide issue. To maximize the number of transplantations, increasing the number of organs transplanted per donor (OTPD) is widely recognized as an important factor for improving the shortage. In Japan, we have had 211 donors, 1112 organs transplanted, and 924 recipients receiving the transplants, resulting in 4.4 ± 1.4 recipients receiving transplants per donor and 5.3 ± 1.6 OTPD as of February 2013. Because donor age is a well-recognized factor of donor suitability, we analyzed the correlation between donor age group and OTPD. Only the age group 60 to 69 years and the age group 70 to 79 years were significantly different (P donor under age 70 years has the potential to donate 4.6 to 6.7 organs. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Correlation of Process Data and Electrochemical Noise to Assess Kraft Digester Corrosion: Kamloops Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Pawel, SJ

    2002-05-09

    Electrochemical noise (ECN) probes were deployed in a carbon steel continuous kraft digester at five locations roughly equi-spaced from top to bottom of the vessel. Current and potential noise, the temperature at each probe location, and the value of about 60 process parameters (flow rates, liquor chemistry, etc.) were monitored continuously for a period of one year. Historical vessel inspection data, including inspections accomplished immediately prior to and immediately following probe deployment, and post-test evaluation of the probe components were used to assess/compare corrosion indications from the probes with physical changes in wall thickness and corrosion patterns on the digester shell. The results indicate that furnish composition is a significant variable influencing digester corrosion, with increasing amounts of Douglas fir in the nominal furnish correlating directly with increased corrosion activity on the ECN probes. All five probes detected changes in furnish composition approximately simultaneously, indicating rapid chemical communication through the liquor, but the effect was strongest and persisted longest relatively high in the digester. The ECN probes also indicate significant corrosion activity occurred at each probe position during shutdown/restart transients. Little or no correlation between ECN probe corrosion activity and other operational variables was observed. Post-test evaluation of the probes confirmed general corrosion of a magnitude that closely agreed with corrosion current sums calculated for each probe over the exposure period and with historical average corrosion rates for the respective locations. Further, no pitting was observed on any of the electrodes, which is consistent with the ECN data, relevant polarization curves developed for steel in liquor removed from the digester, and the post-test inspection of the digester.

  5. Correlation in the statistical analysis of a reverse Fourier neutron time-of-flight experiment. Pt. 2

    International Nuclear Information System (INIS)

    Tilli, K.J.

    1982-01-01

    The significance of the correlation in the statistical analysis of reverse Fourier neutron time-of-flight observations has been evaluated by applying different methods of estimation to diffraction patterns containing peaks with Gaussian line shapes. Effects of the correlation between adjacent channels of a spectrum arise both from the incorrect weighting of the experiment's independent variables and from the misinterpretation of the number of independent observations in the data. The incorrect weighting bears the greatest effects on the width parameter of a Gaussian profile, and it leads to an increase in the relative weights of the broadest peaks of the diffraction pattern. If the correlation is ignored in the analysis, the estimates obtained for the parameters of a model will not be exactly the same as those evaluated from the minimum variance estimation, in which the correlation is taken into account. However, the differences will not be statistically significant. Nevertheless, the standard deviations will then be underestimated typically by a factor of two, which will have serious consequences on every aspect of the statistical inference. (orig.)

  6. The Gelation of Polyvinyl Alcohol with Borax: A Novel Class Participation Experiment Involving the Preparation and Properties of a "Slime."

    Science.gov (United States)

    Casassa, E. Z.; And Others

    1986-01-01

    Background information, procedures used, and typical results obtained are provided for an experiment in which students prepare and study the characteristics of a "slime." A list of general, inorganic, and polymer chemistry concepts fostered in the experiment is included. (JN)

  7. Helium/solid powder O-ring leakage correlation experiments using a radiotracer

    International Nuclear Information System (INIS)

    Bild, R.W.; Leisher, W.B.; Weissman, S.H.; Seya, M.

    1984-01-01

    UO 2 definitely leaked past the O-ring in three of the tests confirming the major results of the previous work. Continuous leakage at these levels may require additional precautions under present regulatory policies. The mechanism and the time and particle size dependence for the leakage are not known, but there is some indication leakage is more likely at low temperatures. It is possible leakage is due to movement of the O-ring during temperature or pressure cycling at the beginning or end of a test. The radiotracer method involves less labor and is much less susceptible to contamination than the previous method. Future work will investigate leakage past lubricated O-rings and time dependence of leakage. 1 reference, 1 table

  8. Photodissociation of OCS: deviations between theory and experiment, and the importance of higher order correlation effects.

    Science.gov (United States)

    Schmidt, J A; Olsen, J M H

    2014-11-14

    The photodissociation of carbonyl sulfide (OCS) was investigated theoretically in a series of studies by Schmidt and co-workers. Initial studies [J. A. Schmidt, M. S. Johnson, G. C. McBane, and R. Schinke, J. Chem. Phys. 136, 131101 (2012); J. A. Schmidt, M. S. Johnson, G. C. McBane, and R. Schinke, J. Chem. Phys. 137, 054313 (2012)] found photodissociation in the first UV-band to occur mainly by excitation of the 2(1)A' (A) excited state. However, in a later study [G. C. McBane, J. A. Schmidt, M. S. Johnson, and R. Schinke, J. Chem. Phys. 138, 094314 (2013)] it was found that a significant fraction of photodissociation must occur by excitation of 1(1)A″ (B) excited state to explain the product angular distribution. The branching between excitation of the A and B excited states is determined by the magnitude of the transition dipole moment vectors in the Franck-Condon region. This study examines the sensitivity of these quantities to changes in the employed electronic structure methodology. This study benchmarks the methodology employed in previous studies against highly correlated electronic structure methods (CC3 and MRAQCC) and provide evidence in support of the picture of the OCS photodissociation process presented in [G. C. McBane, J. A. Schmidt, M. S. Johnson, and R. Schinke, J. Chem. Phys. 138, 094314 (2013)] showing that excitation of A and B electronic states both contribute significantly to the first UV absorption band of OCS. In addition, this study presents evidence in support of the assertion that the A state potential energy surface employed in previous studies underestimates the energy at highly bent geometries (γ ∼ 70°) leading to overestimated rotational energy in the product CO.

  9. Photodissociation of OCS: Deviations between theory and experiment, and the importance of higher order correlation effects

    International Nuclear Information System (INIS)

    Schmidt, J. A.; Olsen, J. M. H.

    2014-01-01

    The photodissociation of carbonyl sulfide (OCS) was investigated theoretically in a series of studies by Schmidt and co-workers. Initial studies [J. A. Schmidt, M. S. Johnson, G. C. McBane, and R. Schinke, J. Chem. Phys. 136, 131101 (2012); J. A. Schmidt, M. S. Johnson, G. C. McBane, and R. Schinke, J. Chem. Phys. 137, 054313 (2012)] found photodissociation in the first UV-band to occur mainly by excitation of the 2 1 A ′ (A) excited state. However, in a later study [G. C. McBane, J. A. Schmidt, M. S. Johnson, and R. Schinke, J. Chem. Phys. 138, 094314 (2013)] it was found that a significant fraction of photodissociation must occur by excitation of 1 1 A ″ (B) excited state to explain the product angular distribution. The branching between excitation of the A and B excited states is determined by the magnitude of the transition dipole moment vectors in the Franck-Condon region. This study examines the sensitivity of these quantities to changes in the employed electronic structure methodology. This study benchmarks the methodology employed in previous studies against highly correlated electronic structure methods (CC3 and MRAQCC) and provide evidence in support of the picture of the OCS photodissociation process presented in [G. C. McBane, J. A. Schmidt, M. S. Johnson, and R. Schinke, J. Chem. Phys. 138, 094314 (2013)] showing that excitation of A and B electronic states both contribute significantly to the first UV absorption band of OCS. In addition, this study presents evidence in support of the assertion that the A state potential energy surface employed in previous studies underestimates the energy at highly bent geometries (γ ∼ 70°) leading to overestimated rotational energy in the product CO

  10. Keeping an eye on the conductor: neural correlates of visuo-motor synchronization and musical experience

    Science.gov (United States)

    Ono, Kentaro; Nakamura, Akinori; Maess, Burkhard

    2015-01-01

    For orchestra musicians, synchronized playing under a conductor’s direction is necessary to achieve optimal performance. Previous studies using simple auditory/visual stimuli have reported cortico-subcortical networks underlying synchronization and that training improves the accuracy of synchronization. However, it is unclear whether people who played regularly under a conductor and non-musicians activate the same networks when synchronizing with a conductor’s gestures. We conducted a functional magnetic resonance imaging (fMRI) experiment testing nonmusicians and musicians who regularly play music under a conductor. Participants were required to tap the rhythm they perceived from silent movies displaying either conductor’s gestures or a swinging metronome. Musicians performed tapping under a conductor with more precision than nonmusicians. Results from fMRI measurement showed greater activity in the anterior part of the left superior frontal gyrus (SFG) in musicians with more frequent practice under a conductor. Conversely, tapping with the metronome did not show any difference between musicians and nonmusicians, indicating that the expertize effect in tapping under the conductor does not result in a general increase in tapping performance for musicians. These results suggest that orchestra musicians have developed an advanced ability to predict conductor’s next action from the gestures. PMID:25883561

  11. Keeping an Eye on the Conductor: Neural Correlates of Visuo-motor Synchronization and Musical Experience

    Directory of Open Access Journals (Sweden)

    Kentaro eOno

    2015-04-01

    Full Text Available For orchestra musicians, synchronized playing under a conductor’s direction is necessary to achieve optimal performance. Previous studies using simple auditory/visual stimuli have reported cortico-subcortical networks underlying synchronization and that training improves the accuracy of synchronization. However, it is unclear whether people who played regularly under a conductor and non-musicians activate the same networks when synchronizing with a conductor’s gestures. We conducted a functional magnetic resonance imaging (fMRI experiment testing nonmusicians and musicians who regularly play music under a conductor. Participants were required to tap the rhythm they perceived from silent movies displaying either conductor’s gestures or a swinging metronome. Musicians performed tapping under a conductor with more precision than nonmusicians. Results from fMRI measurement showed greater activity in the anterior part of the left superior frontal gyrus (SFG in musicians with more frequent practice under a conductor. Conversely, tapping with the metronome did not show any difference between musicians and nonmusicians, indicating that the expertise effect in tapping under the conductor does not result in a general increase in tapping performance for musicians. These results suggest that orchestra musicians have developed an advanced ability to predict conductor’s next action from the gestures.

  12. Territories climate plans: territories in action 21 collectivities involved in the climatic change challenge. 1. experiences collection 2007

    International Nuclear Information System (INIS)

    2007-01-01

    The climate plan invites the collectivities to implement actions of greenhouse reduction. This collection presents the first collectivities involved in a climate approach: towns, natural parks, syndicates, general and regional council. (A.L.B.)

  13. Correlation of MRI with arthroscopy for the evaluation of the subscapularis tendon: a musculoskeletal division's experience

    International Nuclear Information System (INIS)

    Gyftopoulos, Soterios; O'Donnell, John; Shah, Neil Pravin; Goss, Jordan; Babb, James; Recht, Michael P.

    2013-01-01

    To determine the accuracy of MR imaging for the evaluation of the subscapularis tendon as well as define imaging findings that will increase accuracy. Retrospective review of the MR and operative (OR) reports of 286 patients was conducted and reviewed for the presence/degree (partial (PT)/full-thickness (FT)) of tearing; only PT articular tears were included. The presence of a supraspinatus tear and time interval between surgery and MRI were also documented. All of the PT tears called on MRI were also reviewed to see if there was a statistically significant association between certain imaging characteristics and the presence of a tear in surgery. Statistical analysis included 95 % confidence intervals, Fisher's exact, and exact Mann-Whitney tests. A total of 244 patients were included in the study with a total of 25 subscapularis tears, 16 PT and nine FT, and 219 intact tendons in arthroscopy; 20/25 tears and 200 intact tendons were diagnosed correctly on MRI, resulting in sensitivity of 80 %, specificity of 91 %, accuracy of 90 %, positive predictive value of 51 %, and negative predictive value of 98 %. There was a significant association between the presence of a PT tear during arthroscopy and fluid-like signal within the tendon on more than one imaging plane (p < 0.001) with an accuracy of 90 %. This study reflects a musculoskeletal radiology section's experience with the diagnosis of subscapularis tendon pathology, demonstrating that MRI could be used to accurately evaluate the subscapularis tendon. An understanding of certain imaging pitfalls and the presence of fluid-like signal on multiple imaging planes should increase the diagnostic accuracy of the radiologist evaluating the subscapularis tendon for the presence of a tear. (orig.)

  14. Analysis of residuals from enzyme kinetic and protein folding experiments in the presence of correlated experimental noise.

    Science.gov (United States)

    Kuzmic, Petr; Lorenz, Thorsten; Reinstein, Jochen

    2009-12-01

    Experimental data from continuous enzyme assays or protein folding experiments often contain hundreds, or even thousands, of densely spaced data points. When the sampling interval is extremely short, the experimental data points might not be statistically independent. The resulting neighborhood correlation invalidates important theoretical assumptions of nonlinear regression analysis. As a consequence, certain goodness-of-fit criteria, such as the runs-of-signs test and the autocorrelation function, might indicate a systematic lack of fit even if the experiment does agree very well with the underlying theoretical model. A solution to this problem is to analyze only a subset of the residuals of fit, such that any excessive neighborhood correlation is eliminated. Substrate kinetics of the HIV protease and the unfolding kinetics of UMP/CMP kinase, a globular protein from Dictyostelium discoideum, serve as two illustrative examples. A suitable data-reduction algorithm has been incorporated into software DYNAFIT [P. Kuzmic, Anal. Biochem. 237 (1996) 260-273], freely available to all academic researchers from http://www.biokin.com.

  15. Smoke flow temperature beneath tunnel ceiling for train fire at subway station: Reduced-scale experiments and correlations

    International Nuclear Information System (INIS)

    Meng, Na; Wang, Qiang; Liu, Zhaoxia; Li, Xiao; Yang, He

    2017-01-01

    Highlights: • Reduced-scale experiments on train fire at subway station. • Smoke flow temperature beneath tunnel ceiling measured and correlated. • Effect of platform-tunnel conjunction door type on smoke temperature is clarified. - Abstract: This paper is to investigate the smoke flow temperature beneath tunnel ceiling for a train on fire stopping besides a subway station. Experiments were carried out in a reduced-scale (1:10) subway station model to study the maximum smoke temperature and the longitudinal temperature distribution beneath the tunnel ceiling by considering platform-tunnel conjunction doors of two types: the full-seal platform screen door (PSD) and the full-height safety door. For the maximum temperature beneath the tunnel ceiling, it is found to be well correlated non-dimensionally with heat release rate by a 3.65 and a 2.92 power law function for the full-seal platform screen door and the full-height safety door, respectively. For the longitudinal temperature distribution along the tunnel ceiling, it can be well correlated by an exponential function for both types of platform-tunnel conjunction doors. Concerning the effect of the door type, the maximum temperature is lower and the longitudinal temperature decays faster for full-height safety door than that for full-seal PSD. This is due to that with the full-height safety door, the effective width of the tunnel ceiling is widened, which results in more heat losses from the smoke flow to the ceiling.

  16. Correlation of pre-earthquake electromagnetic signals with laboratory and field rock experiments

    Directory of Open Access Journals (Sweden)

    T. Bleier

    2010-09-01

    Full Text Available Analysis of the 2007 M5.4 Alum Rock earthquake near San José California showed that magnetic pulsations were present in large numbers and with significant amplitudes during the 2 week period leading up the event. These pulsations were 1–30 s in duration, had unusual polarities (many with only positive or only negative polarities versus both polarities, and were different than other pulsations observed over 2 years of data in that the pulse sequence was sustained over a 2 week period prior to the quake, and then disappeared shortly after the quake. A search for the underlying physics process that might explain these pulses was was undertaken, and one theory (Freund, 2002 demonstrated that charge carriers were released when various types of rocks were stressed in a laboratory environment. It was also significant that the observed charge carrier generation was transient, and resulted in pulsating current patterns. In an attempt to determine if this phenomenon occurred outside of the laboratory environment, the authors scaled up the physics experiment from a relatively small rock sample in a dry laboratory setting, to a large 7 metric tonne boulder comprised of Yosemite granite. This boulder was located in a natural, humid (above ground setting at Bass Lake, Ca. The boulder was instrumented with two Zonge Engineering, Model ANT4 induction type magnetometers, two Trifield Air Ion Counters, a surface charge detector, a geophone, a Bruker Model EM27 Fourier Transform Infra Red (FTIR spectrometer with Sterling cycle cooler, and various temperature sensors. The boulder was stressed over about 8 h using expanding concrete (Bustartm, until it fractured into three major pieces. The recorded data showed surface charge build up, magnetic pulsations, impulsive air conductivity changes, and acoustical cues starting about 5 h before the boulder actually broke. These magnetic and air conductivity pulse signatures resembled both the laboratory

  17. 3D Simulation as a Learning Environment for Acquiring the Skill of Self-Management: An Experience Involving Spanish University Students of Education

    Science.gov (United States)

    Cela-Ranilla, Jose María; Esteve-Gonzalez, Vanessa; Esteve-Mon, Francesc; Gisbert-Cervera, Merce

    2014-01-01

    In this study we analyze how 57 Spanish university students of Education developed a learning process in a virtual world by conducting activities that involved the skill of self-management. The learning experience comprised a serious game designed in a 3D simulation environment. Descriptive statistics and non-parametric tests were used in the…

  18. Investigation of changes in students’ self-esteem by the experience of maternity nursing practicum and factors involved

    OpenAIRE

    Tsukamoto, Yasuko; Masuda, Akemi

    2010-01-01

    A clinical training is the most effective learning method for nursing students. Students have various learning experiences through communication with patients and families. These are positive experiences for students, but their minds and bodies are also strongly and negatively influenced. The purpose of this study was to develop changes in students' self-esteem and mental health conditions by the maternity nursing practicum. They were the following results. 1) Students were generally satisfie...

  19. Beyond the Bake Sale: Fundraising and Professional Experience for Students Involved in an Information Systems Student Chapter

    Science.gov (United States)

    Snyder, Johnny; Carpenter, Don; Slauson, Gayla Jo; Skinner, Joe; Nash, Cole

    2012-01-01

    Fundraising traditionally involves selling. This paper explores the merits of selling technology services provided by a technology oriented student club to members of a campus community. This club activity puts into practice learning theories presented in the literature. Beyond fundraising, this activity yields many additional benefits to the…

  20. Taking on the Perspective of the Other: Understanding Parents' and Teachers' Perceptions of Parent Involvement in Students' Educational Experiences

    Science.gov (United States)

    Wilson, Rene M.

    2011-01-01

    Parent involvement is considered a vital educational factor that is associated with students' academic success. Engaging parents in the educational process is a challenge confronting many school districts across the United States. This is a significant problem for schools in low socioeconomic communities where lack of resources for parents and…

  1. The realization of three special photovoltaic (PV) pilot projects. The roles and learning experiences of parties involved

    International Nuclear Information System (INIS)

    Geuzendam, C.; Van Mierlo, B.

    1995-11-01

    Experiences with the following three demonstration projects, carried out in the Netherlands, are inventorized and evaluated: (1) 16 private grid-connected PV-systems in existing houses within the framework of the project of the Organization for Renewable Energy (ODE, abbreviated in Dutch); (2) five private grid-connected roof-integrated PV-systems in renovated buildings in Leiden; and (3) the integration of PV in an acoustic baffle along the high-way A-27 near De Bilt. Attention is paid to the decision making processes, the most important actors, the management of the projects and what is learned from the experiences

  2. Experience of emotional stress and resilience in street-involved youth: the need for early mental health intervention.

    Science.gov (United States)

    McCay, Elizabeth

    2011-01-01

    Mental illness left untreated in adolescence and young adulthood can readily become a chronic illness in adulthood, seriously hampering the capacity of individuals to become healthy contributing members of society. Mental health challenges are of paramount importance to the health and well-being of Canadian adolescents and young adults, with 18% of Canadian youth, ages 15-24, reporting a mental illness (Leitch 2007). However, it is unlikely that this statistic accounts for those invisible youth (Rachlis et al. 2009) who are disconnected from families and caregivers, bereft of stable housing and familial support - in other words, youth who are street-involved. Mental health risk is amplified in street-involved youth and, as such, must be recognized as a priority for policy development that commits to accessible mental health programming, in order to realize the potential of these vulnerable youth.

  3. 13C spin relaxation measurements in RNA: Sensitivity and resolution improvement using spin-state selective correlation experiments

    International Nuclear Information System (INIS)

    Boisbouvier, Jerome; Brutscher, Bernhard; Simorre, Jean-Pierre; Marion, Dominique

    1999-01-01

    A set of new NMR pulse sequences has been designed for the measurement of 13 C relaxation rate constants in RNA and DNA bases: the spin-lattice relaxation rate constant R(C z ), the spin-spin relaxation rate constant R(C + ), and the CSA-dipolar cross-correlated relaxation rate constant Γ C,CH xy . The use of spin-state selective correlation techniques provides increased sensitivity and spectral resolution. Sensitivity optimised C-C filters are included in the pulse schemes for the suppression of signals originating from undesired carbon isotopomers. The experiments are applied to a 15% 13 C-labelled 33-mer RNA-theophylline complex. The measured R(C + )/Γ C,CH xy ratios indicate that 13 C CSA tensors do not vary significantly for the same type of carbon (C 2 , C 6 , C 8 ), but that they differ from one type to another. In addition, conformational exchange effects in the RNA bases are detected as a change in the relaxation decay of the narrow 13 C doublet component when varying the spacing of a CPMG pulse train. This new approach allows the detection of small exchange effects with a higher precision compared to conventional techniques

  4. The experience of seeking, gaining and maintaining employment after traumatic spinal cord injury and the vocational pathways involved.

    Science.gov (United States)

    Hilton, Gillean; Unsworth, Carolyn A; Stuckey, Ruth; Murphy, Gregory C

    2018-01-01

    Vocational potential in people with spinal cord injury (SCI) are unrealised with rates of employment substantially lower than in the labour force participation of the general population and the pre-injury employment rates. To understand the experience and pathway of people achieving employment outcome after traumatic spinal cord injury by; classifying participants into employment outcome groups of stable, unstable and without employment; identifying pre and post-injury pathways for participants in each group and, exploring the experiences of people of seeking, gaining and maintaining employment. Thirty-one participants were interviewed. Mixed methods approach including interpretive phenomenological analysis and vocational pathway mapping of quantitative data. The most common pathway identified was from study and work pre-injury to stable employment post-injury. Four super-ordinate themes were identified from the interpretive phenomenological analysis; expectations of work, system impacts, worker identity and social supports. Implications for clinical practice include fostering cultural change, strategies for system navigation, promotion of worker identity and optimal use of social supports. The findings increase insight and understanding of the complex experience of employment after spinal cord injury. There is opportunity to guide experimental research, policy development and education concerning the complexity of the return to work experience and factors that influence pathways.

  5. Striking the Right Balance: Police Experience, Perceptions and Use of Independent Support Persons during Interviews Involving People with Intellectual Disability

    Science.gov (United States)

    Henshaw, Marie; Spivak, Benjamin; Thomas, Stuart D. M.

    2018-01-01

    Background: Several jurisdictions mandate the presence of an independent support person during police interviews with vulnerable people. The current study investigated police officers' experiences and perceptions of these volunteers during interviews with people with intellectual disability(ies) (ID). Methods: The sample comprised 229 police…

  6. Psychiatric patients' preferences and experiences in clinical decision-making: examining concordance and correlates of patients' preferences.

    Science.gov (United States)

    De las Cuevas, Carlos; Peñate, Wenceslao; de Rivera, Luis

    2014-08-01

    To assess the concordance between patients' preferred role in clinical decision-making and the role they usually experience in their psychiatric consultations and to analyze the influence of socio-demographic, clinical and personality characteristics on patients' preferences. 677 consecutive psychiatric outpatients were invited to participate in a cross-sectional survey and 507 accepted. Patients completed Control Preference Scale twice consecutively before consultation, one for their preferences of participation and another for the style they usually experienced until then, and locus of control and self-efficacy scales. Sixty-three percent of psychiatric outpatients preferred a collaborative role in decision-making, 35% preferred a passive role and only a 2% an active one. A low concordance for preferred and experienced participation in medical decision-making was registered, with more than a half of patients wanting a more active role than they actually had. Age and doctors' health locus of control orientation were found to be the best correlates for participation preferences, while age and gender were for experienced. Psychiatric diagnoses registered significant differences in patients' preferences of participation but no concerning experiences. The limited concordance between preferred and experienced roles in psychiatric patients is indicative that clinicians need to raise their sensitivity regarding patient's participation. The assessment of patient's attribution style should be useful for psychiatrist to set objectives and priority in the communication with their patients. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  7. Experimental studies of particle acceleration with ultra-intense lasers - Applications to nuclear physics experiments involving laser-produced plasmas

    International Nuclear Information System (INIS)

    Plaisir, C.

    2010-11-01

    For the last ten years, the Ultra High Intensity Lasers offer the opportunity to produce accelerated particle beams which contain more than 10 12 electrons, protons accelerated into a few ps. We have simulated and developed some diagnostics based on nuclear activation to characterize both the angular and the energy distributions of the particle beams produced with intense lasers. The characterization methods which are presented are illustrated by means of results obtained in different experiments. We would use the particle beams produced to excite nuclear state in a plasma environment. It can modify intrinsic characteristics of the nuclei such as the half-life of some isomeric states. To prepare this kind of experiments, we have measured the nuclear reaction cross section (gamma,n) to produce the isomeric state of the 84 Rb, which has an excitation energy of 463 keV, with the electron accelerator ELSA of CEA/DIF in Bruyeres-le-Chatel (France). (author)

  8. Polymorphism at the ref(2)P locus in Drosophila melanogaster: preliminary experiments concerning the selection mechanisms involved in its maintenance.

    Science.gov (United States)

    Fleuriet, A

    1981-02-01

    It has been shown previously that a polymorphism for two alleles of the ref(2)P locus is a regular feature of French natural populations of Drosophila melanogaster and that this is maintained in laboratory populations raised in cages. In this paper, an experimental population and egg-collection experiments are reported. Differential survival of the three genotypes would be the main factor leading to the equilibrium frequencies, working only in drastic conditions of larval competition.

  9. Profile of Justice-Involved Marijuana and Other Substance Users: Demographics, Health and Health Care, Family, and Justice System Experiences

    Directory of Open Access Journals (Sweden)

    Nikki Freeman

    2017-09-01

    Full Text Available Substance users are more likely to have co-occurring health problems, and this pattern is intensified among those involved with the criminal justice system. Interview data for 1977 incarcerated men in 5 states from the Multi-site Family Study on Incarceration, Parenting, and Partnering that was conducted between December 2008 and August 2011 were analyzed to compare pre-incarceration substance use patterns and health outcomes between men who primarily used marijuana, primarily used alcohol, primarily used other drugs, and did not use any illicit substances during that time. Using regression modeling, we examined the influence of substance use patterns on physical and mental health. Primary marijuana users comprised the largest portion of the sample (31.5%, closely followed by nonusers (30.0%, and those who primarily used other drugs (30.0%; primary alcohol users comprised the smallest group (19.6%. The substance user groups differed significantly from the nonuser group on many aspects of physical and mental health. Findings suggest that even among justice-involved men who are not using “hard” drugs, substance use merits serious attention. Expanding the availability of substance use treatment during and after incarceration might help to promote physical and mental health during incarceration and reentry.

  10. Pair natural orbital and canonical coupled cluster reaction enthalpies involving light to heavy alkali and alkaline earth metals: the importance of sub-valence correlation

    KAUST Repository

    Minenkov, Yury; Bistoni, Giovanni; Riplinger, Christoph; Auer, Alexander A.; Neese, Frank; Cavallo, Luigi

    2017-01-01

    In this work, we tested canonical and domain based pair natural orbital coupled cluster methods (CCSD(T) and DLPNO-CCSD(T), respectively) for a set of 32 ligand exchange and association/dissociation reaction enthalpies involving ionic complexes

  11. Weak mixing and CP-violation involving heavy quarks and possible measurements in e+e- experiments

    International Nuclear Information System (INIS)

    Ali, A.; Aydin, Z.Z.

    1978-09-01

    We evaluate weak mass mixing among the neutral heavy mesons with a bottom (Q = -1/3) or top (Q = +2/3) quark and CP-violation in the frame work of six quark (V - A) models. It is argued that bottom and top mesons may distinguish the Higgs exchange mechanism of CP-violation from a complex phase in the quark mass matrix, if bottom and top quark masses are sufficiently different. Estimates of weak mixing-and CP-violating effects for e + e - experiments at PETRA, PEP and CESR energies are presented. (orig.) [de

  12. Standardized uptake value for (18)F-fluorodeoxyglucose is correlated with a high International Prognostic Index and the presence of extranodal involvement in patients with diffuse large B-cell lymphoma.

    Science.gov (United States)

    Akkas, B E; Vural, G U

    2014-01-01

    The aim of this study was to evaluate whether the maximum standardized uptake value (SUVmax) of (18)F-fluorodeoxyglucose (FDG) correlates with the International Prognostic Index (IPI) and the presence of extranodal involvement in patients with Diffuse Large B-Cell Lymphoma (DLBCL). 77 patients (age: 57.2±18.5, 40F, 37M) with DLBCL who underwent FDG PET/CT for initial staging were included. SUVmax of the predominant lesions were compared to Ann Arbor stage, IPI scores, the presence of extranodal involvement and the number extranodal sites. PET/CT detected nodal (n:25) and extranodal involvement (n:52) in all the patients. In 27 patients, extranodal disease could only be detected by PET. SUVmax of the predominant lesion in patients with extranodal disease was significantly higher than that of the patients who had only nodal disease (25±12 vs. 15.3±10 respectively, p=0.001). SUVmax significantly correlated with IPI scores; the average SUVmax was significantly correlated with the IPI: Mean SUVmax of the predominant lesion was 13.9±9.5 in patients with low risk (IPI=0-1), 14.2±8.8 in low-intermediate risk group (IPI=2) whereas 26.6±9.5 in high-intermediate risk group (IPI=3) and 25±13.6 in high risk group patients (IPI=4-5) (p=0.002). SUVmax was not correlated with clinical stage, the number of extranodal sites and serum LDH levels. FDG uptake correlates with IPI and the presence of extranodal involvement in DLBCL. PET is a powerful method to detect extranodal disease in DLBCL. The correlation of SUVmax with these prognostic factors may highlight the importance of pretreatment FDG uptake as a metabolic marker of poor prognosis for patients with DLBCL. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  13. Review of US accident/incident experience involving the transportation of radioactive material (RAM) 1971-1980

    International Nuclear Information System (INIS)

    McClure, J.D.; Emerson, E.L.

    1980-01-01

    This paper analyzes the transportation accidents and incidents which have occurred in the United States in the period 1971-1980 based upon the information in the Radioactive Material Transportation Accident/Incident Data Base developed by the Transportation Technology Center (TTC) at Sandia National Laboratories. The accident/incident data base incorporates the files of the Hazardous Material Incident Report (HMIR) system operated by the Material Transportation Bureau of the US Department of Transportation (DOT) with additional information obtained from the files of the US Nuclear Regulatory Commission (NRC). A principal objective of this paper is to summarize US accident/incident experience for the past ten years, providing a concise statement of radioactive material (RAM) package failure description for the transport modes of truck, rail and air

  14. Striking the Right Balance: Police Experience, Perceptions and Use of Independent Support Persons During Interviews Involving People with Intellectual Disability.

    Science.gov (United States)

    Henshaw, Marie; Spivak, Benjamin; Thomas, Stuart D M

    2018-03-01

    Several jurisdictions mandate the presence of an independent support person during police interviews with vulnerable people. The current study investigated police officers' experiences and perceptions of these volunteers during interviews with people with intellectual disability(ies) (ID). The sample comprised 229 police officers who attended a mandatory firearms training course in Melbourne, Australia, in 2010. Participants commonly reported utilizing independent support persons and displayed a fair understanding of their role. Overall, volunteers were engaged more frequently than family/friends; police considered the volunteers to be more impartial during interviews, whereas family/friends provided a greater level of emotional support to interviewees. Independent support persons need to demonstrate two quite different types of support to people with intellectual disability(ies) during police interviews; these require quite different skill sets and suggest the need for more tailored training and support for these volunteers. Implications for future research and policy are discussed. © 2016 John Wiley & Sons Ltd.

  15. Heat transfer experiments and correlations for natural and forced circulations of water in rod bundles at low Reynolds numbers

    International Nuclear Information System (INIS)

    Kim, Sung-Ho; El-Genk, Mohamed S.; Rubio, Reuben A.; Bryson, James W.; Foushee, Fabian C.

    1988-01-01

    Experimental heat transfer studies were conducted for fully developed forced and natural flows of water through seven uniformly heated rod bundles, triangularly arrayed with P/D = 1.25, 1.38, and 1.5. In forced circulation experiments, Re ranged from 80 to 50,000 and Pr from 3 to 8.5, while in natural circulation, Re varied from 260 to 2,000, and Ra q from 8 x 10 8 to 2.5 x 10 8 . The forced flow data fell into the two basic flow regimes: turbulent and laminar flow. At the transition between these regimes, Re, which varied from 2,200 for P/D = 1.25 to 5,500 for P/D = 1.5, increased linearly with P/D. The heat transfer data for turbulent flow was within ±15 percent of Weisman's correlation, which was developed for fully developed turbulent flow in rod bundles at Re > 25,000. The laminar flow data showed the dependence of Nu on Re to be weaker than that for turbulent flow, but the exponent of Re increased with P/D: Nu = A Re B Pr 1/3 , where A is equal to 1.061, 0.511, and 0.346 for P/D = 1.25, 1.38 and 1.5, respectively, and B is a linear function of P/D (B = 0.797 P/D - 0.656). Natural circulation data indicated that rod spacing only slightly affected heat transfer, and Nu increased proportionally to Ra 0.25 ; Nu = 0.272 Ra q 0.25 . The application of the results to SNL's ACRR indicated that although the core is cooled by natural convection, either the natural circulation correlation or the forced turbulent flow correlation can be used to accurately predict the single phase heat transfer coefficient in the ACRR. These results were concluded because of the high Rayleigh and Reynolds numbers in the ACRR. The ACRR operates near the boundary between mixed and forced turbulent flow regimes: consequently, achieving the high heat transfer coefficient was possible with natural circulation. (author)

  16. 'No Pink Ribbons': How Women's Lived Experiences With Breast Atypia Inform Decisions Involving Risk-Reducing Medications

    Directory of Open Access Journals (Sweden)

    Sarah L. Goff

    2018-04-01

    Full Text Available Purpose: Atypical hyperplasia (AH is associated with a nearly 4-fold elevation of lifetime risk for breast cancer, and lobular carcinoma in situ (LCIS is associated with a 7- to 8-fold risk. Women with AH/LCIS make numerous decisions in the course of treatment, including whether to take a risk-reducing medication, an option relatively few women pursue. We explored women’s decision-making processes through patient narratives in an effort to inform decision supports for AH/LCIS. Methods: We conducted in-depth interviews with 20 English-speaking women with AH/LCIS and no subsequent diagnosis of invasive breast cancer who had enrolled in the Rays of Hope Center for Breast Cancer Research patient registry between April 5, 2012, and March 31, 2016. Interviews were audiotaped, professionally transcribed, and qualitatively analyzed using thematic qualitative content analysis. Results: We identified three major narrative themes: 1 experiences with medical care; 2 decision-making; and 3 making sense of AH/LCIS. Each major theme had several subthemes, many of which map onto existing decisional theories and heuristics. Subthemes included the impact of life context on diagnosis meaning, emotional responses, changes in self-concept and body image, and understanding of the risk-benefit of risk-reducing medications. Conclusions: This narrative analysis offers important insights into how lived experience may influence decision-making for women with AH/LCIS. Decision supports that focus not only on analytic decisional processes, but also patients’ subjectivities and decisional heuristics, could prove useful for women and their health care providers.

  17. Somatisation in primary care: experiences of primary care physicians involved in a training program and in a randomised controlled trial

    Directory of Open Access Journals (Sweden)

    Salazar Agustín

    2009-11-01

    Full Text Available Abstract Background A new intervention aimed at managing patients with medically unexplained symptoms (MUS based on a specific set of communication techniques was developed, and tested in a cluster randomised clinical trial. Due to the modest results obtained and in order to improve our intervention we need to know the GPs' attitudes towards patients with MUS, their experience, expectations and the utility of the communication techniques we proposed and the feasibility of implementing them. Physicians who took part in 2 different training programs and in a randomised controlled trial (RCT for patients with MUS were questioned to ascertain the reasons for the doctors' participation in the trial and the attitudes, experiences and expectations of GPs about the intervention. Methods A qualitative study based on four focus groups with GPs who took part in a RCT. A content analysis was carried out. Results Following the RCT patients are perceived as true suffering persons, and the relationship with them has improved in GPs of both groups. GPs mostly valued the fact that it is highly structured, that it made possible a more comfortable relationship and that it could be applied to a broad spectrum of patients with psychosocial problems. Nevertheless, all participants consider that change in patients is necessary; GPs in the intervention group remarked that that is extremely difficult to achieve. Conclusion GPs positively evaluate the communication techniques and the interventions that help in understanding patient suffering, and express the enormous difficulties in handling change in patients. These findings provide information on the direction in which efforts for improving intervention should be directed. Trial registration US ClinicalTrials.gov NCT00130988

  18. Correlates of change in student reported parent involvement in schooling: a new look at the National Education Longitudinal Study of 1988.

    Science.gov (United States)

    Stone, Susan

    2006-10-01

    Using a subsample (2174 students, 174 schools) from the National Education Longitudinal Study of 1988 (NELS), this study drew on Eccles and Harold's (1996) framework of parent involvement in schooling to estimate the relative influence of key child, family, and school characteristics on change in three types of student-reported parent involvement in schooling between eighth and tenth grades: home communication about school, monitoring, and direct interactions with schools. It also examines relationships between changes in involvement, change in grade point average (GPA), and dropout. Overall, measured school effects accounted for a small proportion of the variation in changes in home communication and direct parent interactions with schools. Sustained home communication related to higher grades and lower likelihood of dropout, although the size of effects was small. (c) 2007 APA, all rights reserved

  19. Involving stakeholders in the commissioning and implementation of fishery science projects: experiences from the U.K. Fisheries Science Partnership.

    Science.gov (United States)

    Armstrong, M J; Payne, A I L; Deas, B; Catchpole, T L

    2013-10-01

    Following from similar initiatives worldwide, the U.K.'s Fisheries Science Partnership (FSP) was established in 2003 to provide the fishing industry with opportunities to propose and participate in scientific studies in collaboration with fishery scientists. Key concepts were that most of the available funding would support industry participation, that industry, not scientists, would come up with the ideas for projects, and that commercial fishing vessels and fishing methods would be used to address specific concerns of the fishing industry in a scientifically controlled manner. Nearly 100 projects had been commissioned by March 2012, covering annual time-series surveys of stocks subject to traditional assessment, and ad hoc projects on, e.g. gear selectivity, discard survival, tagging and migration and fishery development. The extent to which the results of the projects have been used by stakeholders, fishery scientists and fishery managers at a national and E.U. level is evaluated, along with the degree of industry interest and involvement, and reasons are identified for successes or failures in the uptake of the results into management and policy. Finally, the question is posed whether the programme has been successful in improving the engagement of the fishing community in the science-management process and in fostering communication and greater trust between fishers, scientists and managers. © 2013 Crown Copyright. © 2013 The Fisheries Society of the British Isles.

  20. Families in Assertive Community Treatment (ACT) Teams in Norway: A Cross-Sectional Study on Relatives' Experiences of Involvement and Alienation.

    Science.gov (United States)

    Weimand, B M; Israel, P; Ewertzon, M

    2017-11-10

    International research shows that relatives of people with mental illness are rarely involved by mental health services. Assertive Community Treatment (ACT) has been recently implemented in Norway. The experience of relatives of ACT users is largely unknown. The aim of this study was to explore relatives' experience with ACT-teams in Norway. Data were collected using the family involvement and alienation questionnaire, consisting of experiences of approach, and alienation from the provision of professional care. 38 Relatives participated in this study. A majority experienced a positive approach (openness, confirmation, and cooperation) from the ACT teams, which also was considered better compared to previous services. They considered openness and cooperation as essential aspects from the professionals. Almost half did not feel alienated (powerlessness and social isolation). Higher level of being approached positively was significantly associated with lower level of feeling alienated. The knowledge of what constituted relatives' positive experiences with the ACT teams should be transferred into practice regarding how to form a positive alliance with relatives.

  1. Carers' experiences of involvement in care planning: a qualitative exploration of the facilitators and barriers to engagement with mental health services.

    Science.gov (United States)

    Cree, Lindsey; Brooks, Helen L; Berzins, Kathryn; Fraser, Claire; Lovell, Karina; Bee, Penny

    2015-08-29

    Formal recognition and involvement of carers in mental health services has been the focus of recent policy and practice initiatives as well as being supported by carers themselves. However, carers still report feeling marginalised and distanced from services. A prominent theme is that that they are not listened to and their concerns are not taken seriously. Compared to service user views, the reasons underpinning carers' dissatisfaction with care-planning procedures have been relatively neglected in the research literature, despite the substantial and significant contribution that they make to mental health services. The aim of the study was to explore carers' experiences of the care planning process for people with severe mental illness. Qualitative interviews and focus groups were undertaken with carers. Data were combined and analysed using framework analysis. Whilst identifying a shared desire for involvement and confirming a potential role for carers within services, our data highlighted that many carers perceive a lack of involvement in care planning and a lack of recognition and appreciation of their role from health professionals. Barriers to involvement included structural barriers, such as the timing and location of meetings, cultural barriers relating to power imbalances within the system and specific barriers relating to confidentiality. This qualitative study led by a researcher who was a carer herself has developed the understanding of the potential role of carers within the care planning process within mental health services, along with the facilitators and barriers to achieving optimal involvement.

  2. Assisted reproduction involving gestational surrogacy: an analysis of the medical, psychosocial and legal issues: experience from a large surrogacy program.

    Science.gov (United States)

    Dar, Shir; Lazer, Tal; Swanson, Sonja; Silverman, Jan; Wasser, Cindy; Moskovtsev, Sergey I; Sojecki, Agata; Librach, Clifford L

    2015-02-01

    What are the medical, psychosocial and legal aspects of gestational surrogacy (GS), including pregnancy outcomes and complications, in a large series? Meticulous multidisciplinary teamwork, involving medical, legal and psychosocial input for both the intended parent(s) (IP) and the gestational carrier (GC), is critical to achieve a successful GS program. Small case series have described pregnancy rates of 17-50% for GS. There are no large case series and the medical, legal and psychological aspects of GS have not been addressed in most of these studies. To our knowledge, this is the largest reported GS case series. A retrospective cohort study was performed. Data were collected from 333 consecutive GC cycles between 1998 and 2012. There were 178 pregnancies achieved out of 333 stimulation cycles, including fresh and frozen transfers. The indications for a GC were divided into two groups. Those who have 'failed to carry', included women with recurrent implantation failure (RIF), recurrent pregnancy loss (RPL) and previous poor pregnancy outcome (n = 96; 132 cycles, pregnancy rate 50.0%). The second group consisted of those who 'cannot carry' including those with severe Asherman's syndrome, uterine malformations/uterine agenesis and maternal medical diseases (n = 108, 139 cycles, pregnancy rate 54.0%). A third group, of same-sex male couples and single men, were analyzed separately (n = 52, 62 cycles, pregnancy rate 59.7%). In 49.2% of cycles, autologous oocytes were used and 50.8% of cycles involved donor oocytes. The 'failed to carry' group consisted of 96 patients who underwent 132 cycles at a mean age of 40.3 years. There were 66 pregnancies (50.0%) with 17 miscarriages (25.8%) and 46 confirmed births (34.8%). The 'cannot carry pregnancy' group consisted of 108 patients who underwent 139 cycles at a mean age of 35.9 years. There were 75 pregnancies (54.0%) with 15 miscarriages (20.0%) and 56 confirmed births (40.3%). The pregnancy, miscarriage and live birth

  3. Correlates of Parents' Involvement with Their Adolescent Children in Restructured and Biological Two-Parent Families: The Role of Child Characteristics

    Science.gov (United States)

    Flouri, Eirini

    2004-01-01

    This study used data from both 225 fathers and mothers as well as their secondary school age children to explore the role of child characteristics (sex, age, self-esteem, and emotional and behavioural well-being) in mother's and father's involvement in biological and restructured (stepfather) two-parent families after controlling for known…

  4. Study of charmless $B_{(s)}$ meson decays involving $\\eta'$ and $\\phi$ intermediate states at the LHCb experiment

    CERN Document Server

    Prisciandaro, Jessica; Blanc, Frédéric

    LHCb is one of the four main experiments located at the Large Hadron Collider (LHC) at CERN, and has collected about 3 ${\\rm fb}^{-1}$ of proton-proton collisions at $\\sqrt{s}= 7$ TeV and 8 TeV between December 2009 and December 2012. Designed for the study of $B$-meson decays and for precision $CP$-violation measurements, the LHCb detector requires a high resolution vertex reconstruction, a precise measurement of the charged particle's momentum and an excellent particle identification. In this thesis, a study of the LHCb magnetic field map and two physics analyses are presented. Based on the magnetic field measurements collected during a dedicated campaign in February 2011, the magnetic field map is corrected for mis-alignments, considering global translations and rotations. A more reliable mapping of the field is provided, and is used for the LHCb event reconstruction since June 2011. As a consequence of this study, the mass resolution is improved, and a better agreement between the software alignment and t...

  5. SLAC's Polarized Electron Source LaserSystem and Minimization of Helicity Correlations for the E-158 Parity Violation Experiment

    CERN Document Server

    Humensky, T

    2002-01-01

    SLAC E-158 is an experiment designed to make the first measurement of parity violation in Moeller scattering. E-158 will measure the right-left cross-section asymmetry, A sub L sub R sup M sup o sup e sup l sup l sup e sup r , in the elastic scattering of a 45-GeV polarized electron beam off unpolarized electrons in a liquid hydrogen target. E-158 plans to measure the expected Standard Model asymmetry of approx 10 sup - sup 7 to an accuracy of better than 10 sup - sup 8. To make this measurement, the polarized electron source requires for operation an intense circularly polarized laser beam and the ability to quickly switch between right- and left-helicity polarization states with minimal right-left helicity-correlated asymmetries in the resulting beam parameters (intensity, position, angle, spot size, and energy), sup b sup e sup a sup m A sub L sub R 's. This laser beam is produced by a unique SLAC-designed flashlamp-pumped Ti:Sapphire laser and is propagated through a carefully designed set of polarization...

  6. Analysis of the Variability of Epstein-Barr Virus Genes in Infectious Mononucleosis: Investigation of the Potential Correlation with Biochemical Parameters of Hepatic Involvement

    Directory of Open Access Journals (Sweden)

    Banko Ana

    2016-09-01

    Full Text Available Background: Primary Epstein-Barr virus (EBV infection is usually asymptomatic, although at times it results in the benign lymphoproliferative disease, infectious mononucleosis (IM, during which almost half of patients develop hepatitis. The aims of the present study are to evaluate polymorphisms of EBV genes circulating in IM isolates from this geographic region and to investigate the correlation of viral sequence patterns with the available IM biochemical parameters.

  7. Analysis of the Variability of Epstein-Barr Virus Genes in Infectious Mononucleosis: Investigation of the Potential Correlation with Biochemical Parameters of Hepatic Involvement.

    Science.gov (United States)

    Banko, Ana; Lazarevic, Ivana; Stevanovic, Goran; Cirkovic, Andja; Karalic, Danijela; Cupic, Maja; Banko, Bojan; Milovanovic, Jovica; Jovanovic, Tanja

    2016-09-01

    Primary Epstein-Barr virus (EBV) infection is usually asymptomatic, although at times it results in the benign lymphoproliferative disease, infectious mononucleosis (IM), during which almost half of patients develop hepatitis. The aims of the present study are to evaluate polymorphisms of EBV genes circulating in IM isolates from this geographic region and to investigate the correlation of viral sequence patterns with the available IM biochemical parameters. The study included plasma samples from 128 IM patients. The genes EBNA2, LMP1 , and EBNA1 were amplified using nested-PCR. EBNA2 genotyping was performed by visualization of PCR products using gel electrophoresis. Investigation of LMP1 and EBNA1 included sequence, phylogenetic, and statistical analyses. The presence of EBV DNA in plasma samples showed correlation with patients' necessity for hospitalization (p=0.034). The majority of EBV isolates was genotype 1. LMP1 variability showed 4 known variants, and two new deletions (27-bp and 147-bp). Of the 3 analyzed attributes of LMP1 isolates, the number of 33-bp repeats less than the reference 4.5 was the only one that absolutely correlated with the elevated levels of transaminases. EBNA1 variability was presented by prototype subtypes. A particular combination of EBNA2, LMP1 , and EBNA1 polymorphisms, deleted LMP1/P-thr and non-deleted LMP1/P-ala , as well as genotype 1/ 4.5 33-bp LMP1 repeats or genotype 2/ 4.5 33-bp LMP1 repeats showed correlation with elevated AST (aspartate aminotransferase) and ALT (alanine transaminase). This is the first study which identified the association between EBV variability and biochemical parameters in IM patients. These results showed a possibility for the identification of hepatic related diagnostic EBV markers.

  8. Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing.

    Science.gov (United States)

    Schneider-Hassloff, H; Straube, B; Jansen, A; Nuscheler, B; Wemken, G; Witt, S H; Rietschel, M; Kircher, T

    2016-07-01

    The oxytocin system is involved in human social behavior and social cognition such as attachment, emotion recognition and mentalizing (i.e. the ability to represent mental states of oneself and others). It is shaped by social experiences in early life, especially by parent-infant interactions. The single nucleotid polymorphism rs53576 in the oxytocin receptor (OXTR) gene has been linked to social behavioral phenotypes. In 195 adult healthy subjects we investigated the interaction of OXTR rs53576 and childhood attachment security (CAS) on the personality traits "adult attachment style" and "alexithymia" (i.e. emotional self-awareness), on brain structure (voxel-based morphometry) and neural activation (fMRI) during an interactive mentalizing paradigm (prisoner's dilemma game; subgroup: n=163). We found that in GG-homozygotes, but not in A-allele carriers, insecure childhood attachment is - in adulthood - associated with a) higher attachment-related anxiety and alexithymia, b) higher brain gray matter volume of left amygdala and lower volumes in right superior parietal lobule (SPL), left temporal pole (TP), and bilateral frontal regions, and c) higher mentalizing-related neural activity in bilateral TP and precunei, and right middle and superior frontal gyri. Interaction effects of genotype and CAS on brain volume and/or function were associated with individual differences in alexithymia and attachment-related anxiety. Interactive effects were in part sexually dimorphic. The interaction of OXTR genotype and CAS modulates adult personality as well as brain structure and function of areas implicated in salience processing and mentalizing. Rs53576 GG-homozygotes are partially more susceptible to childhood attachment experiences than A-allele carriers. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Direct measurements of employees involved in the Fukushima Daiichi Nuclear Power Station accident for internal dose estimates. JAEA's experiences

    Energy Technology Data Exchange (ETDEWEB)

    Kurihara, Osamu; Kanai, Katsuta; Nakagawa, Takahiro; Takada, Chie; Momose, Takumaro; Furuta, Sadaaki [Japan Atomic Energy Agency, Nuclear Fuel Cycle Engineering Laboratories, Tokai, Ibaraki (Japan)

    2012-11-15

    Japan Atomic Energy Agency (JAEA) performed internal dose measurements of employees involved in the Fukushima Daiichi nuclear power station accident. Nuclear Fuel Cycle Engineering Laboratories (NFCEL), one of the JAEA's core centers, examined 560 of these employees by direct (in vivo) measurements during the period from April 20 to August 5 in 2011. These measurements consisted of whole-body counting for radiocesium and thyroid counting for radioiodine. The whole-body counting was conducted with two types of whole-body counters (WBCs): a standing-type WBC with two large NaI(Tl) detectors (Fastscan{sup TM}, Canberra Inc.) and a chair-type WBC with HPGe detectors (GC5021, Canberra Inc.) installed in a shielded chamber made of 20-cm-thick steel. The thyroid counting was mainly performed using one of the two HPGe detectors equipped with the chair-type WBC. The subjects examined in this work were divided into two groups: Group 1 was the first 39 subjects who were measured up to June 17, 2011 and Group 2 was the remaining 521 subjects who were measured on and after June 18, 2011. The performance of our direct measurements was validated by comparing measurement results of the Group 1 subjects using two different methods (e.g., the standing-type WBC vs. the chair-type WBC). Tentative internal dose estimates of the subjects of Group 1 were also performed based on the assumption of a single intake scenario on either March 12, when the first hydrogen explosion occurred at the station or the first day of work after the accident. It was found that the contribution of {sup 131}I to the total internal dose greatly exceeded those of {sup 134}Cs and {sup 137}Cs, the other major nuclides detected in the measurements. The maximum committed effective dose (CED) was found in a male subject whose thyroid content of {sup 131}I was 9760 Bq on May 23, 2011; the CED of this subject was estimated to be 600 mSv including a small contribution of {sup 134}Cs and {sup 137}Cs. The typical

  10. Sugar-to-base correlation in nucleic acids with a 5D APSY-HCNCH or two 3D APSY-HCN experiments

    Energy Technology Data Exchange (ETDEWEB)

    Kraehenbuehl, Barbara; Hofmann, Daniela; Maris, Christophe; Wider, Gerhard, E-mail: gsw@mol.biol.ethz.ch [Institute of Molecular Biology and Biophysics (Switzerland)

    2012-02-15

    A five-dimensional (5D) APSY (automated projection spectroscopy) HCNCH experiment is presented, which allows unambiguous correlation of sugar to base nuclei in nucleic acids. The pulse sequence uses multiple quantum (MQ) evolution which enables long constant-time evolution periods in all dimensions, an improvement that can also benefit non-APSY applications. Applied with an RNA with 23 nucleotides the 5D APSY-HCNCH experiment produced a complete and highly precise 5D chemical shift list within 1.5 h. Alternatively, and for molecules where the out-and-stay 5D experiment sensitivity is not sufficient, a set of out-and-back 3D APSY-HCN experiments is proposed: an intra-base (3D APSY-b-HCN) experiment in an MQ or in a TROSY version, and an MQ sugar-to-base (3D APSY-s-HCN) experiment. The two 3D peak lists require subsequent matching via the N1/9 chemical shift values to one 5D peak list. Optimization of the 3D APSY experiments for maximal precision in the N1/9 dimension allowed matching of all {sup 15}N chemical shift values contained in both 3D peak lists. The precise 5D chemical shift correlation lists resulting from the 5D experiment or a pair of 3D experiments also provide a valuable basis for subsequent connection to chemical shifts derived with other experiments.

  11. Sugar-to-base correlation in nucleic acids with a 5D APSY-HCNCH or two 3D APSY-HCN experiments

    International Nuclear Information System (INIS)

    Krähenbühl, Barbara; Hofmann, Daniela; Maris, Christophe; Wider, Gerhard

    2012-01-01

    A five-dimensional (5D) APSY (automated projection spectroscopy) HCNCH experiment is presented, which allows unambiguous correlation of sugar to base nuclei in nucleic acids. The pulse sequence uses multiple quantum (MQ) evolution which enables long constant-time evolution periods in all dimensions, an improvement that can also benefit non-APSY applications. Applied with an RNA with 23 nucleotides the 5D APSY-HCNCH experiment produced a complete and highly precise 5D chemical shift list within 1.5 h. Alternatively, and for molecules where the out-and-stay 5D experiment sensitivity is not sufficient, a set of out-and-back 3D APSY-HCN experiments is proposed: an intra-base (3D APSY-b-HCN) experiment in an MQ or in a TROSY version, and an MQ sugar-to-base (3D APSY-s-HCN) experiment. The two 3D peak lists require subsequent matching via the N1/9 chemical shift values to one 5D peak list. Optimization of the 3D APSY experiments for maximal precision in the N1/9 dimension allowed matching of all 15 N chemical shift values contained in both 3D peak lists. The precise 5D chemical shift correlation lists resulting from the 5D experiment or a pair of 3D experiments also provide a valuable basis for subsequent connection to chemical shifts derived with other experiments.

  12. Chronic Caloric Restriction and Exercise Improve Metabolic Conditions of Dietary-Induced Obese Mice in Autophagy Correlated Manner without Involving AMPK

    Directory of Open Access Journals (Sweden)

    Mingxia Cui

    2013-01-01

    Full Text Available Aim. To investigate the role of AMPK activation and autophagy in mediating the beneficial effects of exercise and caloric restriction in obesity. Methods. Dietary-induced obesity mice were made and divided into 5 groups; one additional group of normal mice serves as control. Mice in each group received different combinations of interventions including low fat diet, caloric restriction, and exercise. Then their metabolic conditions were assessed by measuring serum glucose and insulin, serum lipids, and liver function. AMPK phosphorylation and autophagy activity were detected by western blotting. Results. Obese mice models were successfully induced by high fat diet. Caloric restriction consistently improved the metabolic conditions of the obese mice, and the effects are more prominent than the mice that received only exercise. Also, caloric restriction, exercise, and low fat diet showed a synergistic effect in the improvement of metabolic conditions. Western blotting results showed that this improvement was not related with the activation of AMPK in liver, skeletal muscle, or heart but correlates well with the autophagy activity. Conclusion. Caloric restriction has more prominent beneficial effects than exercise in dietary-induced obese mice. These effects are correlated with the autophagy activity and may be independent of AMPK activation.

  13. Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress

    Directory of Open Access Journals (Sweden)

    Olga Loseva

    2014-07-01

    Full Text Available The risks of non-cancerous diseases associated with exposure to low doses of radiation are at present not validated by epidemiological data, and pose a great challenge to the scientific community of radiation protection research. Here, we show that premature senescence is induced in human fibroblasts when exposed to chronic low dose rate (LDR exposure (5 or 15 mGy/h of gamma rays from a 137Cs source. Using a proteomic approach we determined differentially expressed proteins in cells after chronic LDR radiation compared to control cells. We identified numerous proteins involved in protection against oxidative stress, suggesting that these pathways protect against premature senescence. In order to further study the role of oxidative stress for radiation induced premature senescence, we also used human fibroblasts, isolated from a patient with a congenital deficiency in glutathione synthetase (GS. We found that these GS deficient cells entered premature senescence after a significantly shorter time of chronic LDR exposure as compared to the GS proficient cells. In conclusion, we show that chronic LDR exposure induces premature senescence in human fibroblasts, and propose that a stress induced increase in reactive oxygen species (ROS is mechanistically involved.

  14. Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression

    DEFF Research Database (Denmark)

    Romme Christensen, Jeppe; Börnsen, Lars; Ratzer, Rikke

    2013-01-01

    with disease progression, using flow cytometry and gene expression analysis of CD4(+) and CD8(+)T-cells, B-cells, monocytes and dendritic cells. Furthermore, gene expression of cerebrospinal fluid cells was studied. Flow cytometry studies revealed increased frequencies of ICOS(+)TFH-cells in peripheral blood...... increased in PPMS and SPMS. In the analysis of B-cells, we found a significant increase of plasmablasts and DC-SIGN(+) and CD83(+)B-cells in SPMS. ICOS(+)TFH-cells and DC-SIGN(+)B-cells correlated with disease progression in SPMS patients. Gene expression analysis of peripheral blood cell subsets...... substantiated the flow cytometry findings by demonstrating increased expression of IL21, IL21R and ICOS in CD4(+)T-cells in progressive MS. Cerebrospinal fluid cells from RRMS and progressive MS (pooled SPMS and PPMS patients) had increased expression of TFH-cell and plasmablast markers. In conclusion...

  15. The curious influence of timing on the magical experience evoked by conjuring tricks involving false transfer: decay of amodal object permanence?

    Science.gov (United States)

    Beth, Tessa; Ekroll, Vebjørn

    2015-07-01

    In magic tricks involving false transfer, the conjurer typically creates the illusion of transferring a coin from one hand into the other, which is then closed into a fist, while in reality the coin is kept hidden in the first hand. The magical experience occurs when the closed fist of the second hand is opened and shown to be empty. According to professional magicians, the magical experience evoked by this kind of tricks becomes noticeably weaker when the time interval between the false transfer and the opening of the fist increases. This observation is surprising, given that neither the length of this interval nor any obvious factors associated with it can be expected to change the spectators' intellectual conviction regarding the true location of the coin. We performed a controlled psychological experiment and obtained results corroborating these informal observations. Increasing the temporal interval from 1 to 32 s led to an average reduction of the strength of the magical experience of 38%. We discuss potential explanations of this curious phenomenon in terms of object persistence, object files and temporal amodal completion.

  16. Exercise prescription for non-specific chronic low back pain (NSCLBP): a qualitative study of patients' experiences of involvement in decision making.

    Science.gov (United States)

    Stenner, Rob; Swinkels, Annette; Mitchell, Theresa; Palmer, Shea

    2016-12-01

    The culture of current clinical practice calls for collaboration between therapists and patients, sharing power and responsibility. This paper reports on the findings of a qualitative study of exercise prescription for patients with NSCLBP, taking into account issues such as decision making and how this accords with patient preferences and experiences. To understand the treatment decision making experiences, information and decision support needs of patients with NSCLBP who have been offered exercise as part of their management plan. A qualitative study using a philosophical hermeneutic approach. Semi-structured interviews with eight patients (including use of brief patient vignettes) was undertaken to explore their personal experiences of receiving exercise as part of the management of their NSCLBP, and their involvement in decisions regarding their care. The findings provide a detailed insight into patients' perceptions and experiences of receiving exercise-based management strategies. Four themes were formed from the texts: (1) patients' expectations and patients' needs are not synonymous, (2) information is necessary but often not sufficient, (3) not all decisions need to be shared, and (4) wanting to be treated as an individual. Shared decision making did not appear to happen in physiotherapy clinical practice, but equally may not be what every patient wants. The overall feeling of the patients was that the therapist was dominant in structuring the interactions, leaving the patients feeling disempowered to question and contribute to the decision making. Copyright © 2015 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

  17. Early visual experience and the recognition of basic facial expressions: involvement of the middle temporal and inferior frontal gyri during haptic identification by the early blind.

    Science.gov (United States)

    Kitada, Ryo; Okamoto, Yuko; Sasaki, Akihiro T; Kochiyama, Takanori; Miyahara, Motohide; Lederman, Susan J; Sadato, Norihiro

    2013-01-01

    Face perception is critical for social communication. Given its fundamental importance in the course of evolution, the innate neural mechanisms can anticipate the computations necessary for representing faces. However, the effect of visual deprivation on the formation of neural mechanisms that underlie face perception is largely unknown. We previously showed that sighted individuals can recognize basic facial expressions by haptics surprisingly well. Moreover, the inferior frontal gyrus (IFG) and posterior superior temporal sulcus (pSTS) in the sighted subjects are involved in haptic and visual recognition of facial expressions. Here, we conducted both psychophysical and functional magnetic-resonance imaging (fMRI) experiments to determine the nature of the neural representation that subserves the recognition of basic facial expressions in early blind individuals. In a psychophysical experiment, both early blind and sighted subjects haptically identified basic facial expressions at levels well above chance. In the subsequent fMRI experiment, both groups haptically identified facial expressions and shoe types (control). The sighted subjects then completed the same task visually. Within brain regions activated by the visual and haptic identification of facial expressions (relative to that of shoes) in the sighted group, corresponding haptic identification in the early blind activated regions in the inferior frontal and middle temporal gyri. These results suggest that the neural system that underlies the recognition of basic facial expressions develops supramodally even in the absence of early visual experience.

  18. Early visual experience and the recognition of basic facial expressions: involvement of the middle temporal and inferior frontal gyri during haptic identification by the early blind

    Science.gov (United States)

    Kitada, Ryo; Okamoto, Yuko; Sasaki, Akihiro T.; Kochiyama, Takanori; Miyahara, Motohide; Lederman, Susan J.; Sadato, Norihiro

    2012-01-01

    Face perception is critical for social communication. Given its fundamental importance in the course of evolution, the innate neural mechanisms can anticipate the computations necessary for representing faces. However, the effect of visual deprivation on the formation of neural mechanisms that underlie face perception is largely unknown. We previously showed that sighted individuals can recognize basic facial expressions by haptics surprisingly well. Moreover, the inferior frontal gyrus (IFG) and posterior superior temporal sulcus (pSTS) in the sighted subjects are involved in haptic and visual recognition of facial expressions. Here, we conducted both psychophysical and functional magnetic-resonance imaging (fMRI) experiments to determine the nature of the neural representation that subserves the recognition of basic facial expressions in early blind individuals. In a psychophysical experiment, both early blind and sighted subjects haptically identified basic facial expressions at levels well above chance. In the subsequent fMRI experiment, both groups haptically identified facial expressions and shoe types (control). The sighted subjects then completed the same task visually. Within brain regions activated by the visual and haptic identification of facial expressions (relative to that of shoes) in the sighted group, corresponding haptic identification in the early blind activated regions in the inferior frontal and middle temporal gyri. These results suggest that the neural system that underlies the recognition of basic facial expressions develops supramodally even in the absence of early visual experience. PMID:23372547

  19. Imaging correlated three-particle continuum states. Experiment and theory on the non-adiabatic projection of bound triatomic hydrogen into three separated atoms

    International Nuclear Information System (INIS)

    Fechner, Peer Cornelis

    2015-01-01

    The central topic of this thesis is the experimental observation and the theoretical modeling of non-adiabatic three-body dissociation of H_3 and D_3 neutral triatomic hydrogen molecules. Our goal is to lend a meaning to the observed momentum vector correlation (MVC) of the three emerging ground state hydrogen atoms, for example H_3→H(1s)+H(1s)+H(1s), in terms of symmetries of the nuclear molecular wave function and of the non-adiabatic coupling which initiates this decay. In many experiments carried out over the years, a wealth of state specific MVCs was collected by different research groups. The MVCs are imaged in form of so-called Dalitz plots which show a rich structure of maxima and nodal lines, depending on the initial state of the triatomic hydrogen neutral. Theory was slow to catch up with experiment and only by this year, 2015, a general agreement was accomplished. Nevertheless, these models lack of an easy understanding of the underlying physics as many numerical calculations are involved. The theoretical model presented in this thesis follows a different approach which is more guided by the imaging character of our experiments. We concentrate on a rather qualitative treatment by limiting ourselves to the essential ingredients only. This proceeding contributes to giving a physical interpretation of the structures in the Dalitz plots in the following form: Three-particle coincident imaging offers a direct view of the emerging spatial continuum wave function of a predissociating triatomic molecule as it evolves from molecular spatial dimensions into the realm of independent free particles. This latter result is discussed in the context of the so-called Imaging Theorem, the second main part of this work. A third major part of this thesis pertains to obtaining molecular momentum wave functions in separated degrees-of-freedom via Fourier transformation. Even for triatomic hydrogen - the most simple polyatomic molecule - this is a challenging task. The

  20. Phenomenological analysis of angular correlations in 7 TeV proton-proton collisions from the CMS experiment

    International Nuclear Information System (INIS)

    Ray, R. L.

    2011-01-01

    A phenomenological analysis is presented of recent two-particle angular correlation data on relative pseudorapidity (η) and azimuth reported by the Compact Muon Solenoid (CMS) Collaboration for √(s)=7 TeV proton-proton collisions. The data are described with an empirical jetlike model developed for similar angular correlation measurements obtained from heavy-ion collisions at the Relativistic Heavy-Ion Collider (RHIC). The sameside (small relative azimuth), η-extended correlation structure, referred to as the ridge, is compared with three phenomenological correlation structures suggested by theoretical analysis. These include additional angular correlations due to soft gluon radiation in 2→3 partonic processes, a one-dimensional sameside correlation ridge on azimuth motivated, for example, by color-glass condensate models, and an azimuth quadrupole similar to that required to describe heavy-ion angular correlations. The quadrupole model provides the best overall description of the CMS data, including the ridge, based on χ 2 minimization in agreement with previous studies. Implications of these results with respect to possible mechanisms for producing the CMS sameside correlation ridge are discussed.

  1. Cellular determinants involving mitochondrial dysfunction, oxidative stress and apoptosis correlate with the synergic cytotoxicity of epigallocatechin-3-gallate and menadione in human leukemia Jurkat T cells.

    Science.gov (United States)

    Tofolean, Ioana Teodora; Ganea, Constanta; Ionescu, Diana; Filippi, Alexandru; Garaiman, Alexandru; Goicea, Alexandru; Gaman, Mihnea-Alexandru; Dimancea, Alexandru; Baran, Irina

    2016-01-01

    We have investigated the growth-suppressive action of epigallocatechin-3-gallate (EGCG) on human leukemia Jurkat T cells. Results show a strong correlation between the dose-dependent reduction of clonogenic survival following acute EGCG treatments and the EGCG-induced decline of the mitochondrial level of Ca(2+). The cell killing ability of EGCG was synergistically enhanced by menadione. In addition, the cytotoxic effect of EGCG applied alone or in combination with menadione was accompanied by apoptosis induction. We also observed that in acute treatments EGCG displays strong antioxidant properties in the intracellular milieu, but concurrently triggers some oxidative stress generating mechanisms that can fully develop on a longer timescale. In parallel, EGCG dose-dependently induced mitochondrial depolarization during exposure, but this condition was subsequently reversed to a persistent hyperpolarized mitochondrial state that was dependent on the activity of respiratory Complex I. Fluorimetric measurements suggest that EGCG is a mitochondrial Complex III inhibitor and indicate that EGCG evokes a specific cellular fluorescence with emission at 400nm and two main excitation bands (at 330nm and 350nm) that may originate from a mitochondrial supercomplex containing dimeric Complex III and dimeric ATP-synthase, and therefore could provide a valuable means to characterize the functional properties of the respiratory chain. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. The perturbation theory in the fundamental mode. Its application to the analysis of neutronic experiments involving small amounts of materials in fast neutron multiplying media

    International Nuclear Information System (INIS)

    Remsak, Stanislav.

    1975-01-01

    The formalism of the perturbation theory at the first order, is developed in its simplest form: diffusion theory in the fundamental mode and then the more complex formalism of the transport theory in the fundamental mode. A comparison shows the effect of the angular correlation between the fine structures of the flux and its adjoint function, the difference in the treatment of neutron leakage phenomena, and the existence of new terms in the perturbation formula, entailing a reactivity representation in the diffusion theory that is not quite exact. Problems of using the formalism developed are considered: application of the multigroup formalism, transients of the flux and its adjoint function, validity of the first order approximation etc. A detailed analysis allows the formulation of a criterion specifying the validity range. Transients occuring in the reference medium are also treated. A set of numerical tests for determining a method of elimination of transient effects is presented. Some differential experiments are then discussed: sodium blowdown in enriched uranium or plutonium cores, experiments utilizing some structural materials (iron and oxygen) and plutonium sample oscillations. The Cadarache version II program was systematically used but the analysis of the experiments of plutonium sample oscillation in Ermine required the Cadarache version III program [fr

  3. Inversion duplication deletions involving the long arm of chromosome 13: phenotypic description of additional three fetuses and genotype-phenotype correlation.

    Science.gov (United States)

    Quelin, Chloe; Spaggiari, Emmanuel; Khung-Savatovsky, Suonavy; Dupont, Celine; Pasquier, Laurent; Loeuillet, Laurence; Jaillard, Sylvie; Lucas, Josette; Marcorelles, Pascale; Journel, Hubert; Pluquailec-Bilavarn, Khantaby; Bazin, Anne; Verloes, Alain; Delezoide, Anne-Lise; Aboura, Azzedine; Guimiot, Fabien

    2014-10-01

    Inversion duplication and terminal deletion of the long arm of chromosome 13 (inv dup del 13q) is a rare chromosomal rearrangement: only five patients have been reported, mostly involving a ring chromosome 13. We report on additional three fetuses with pure inv dup del 13q: Patient 1 had macrosomia, enlarged kidneys, hypersegmented lungs, unilateral moderate ventriculomegaly, and a mild form of hand and feet preaxial polydactyly; Patient 2 had intrauterine growth retardation, widely spaced eyes, left microphthalmia, right anophthalmia, short nose, bilateral absent thumbs, cutaneous syndactyly of toes 4 and 5, bifid third metacarpal, a small left kidney, hyposegmented lungs, and partial agenesis of the corpus callosum; Patient 3 had widely spaced eyes, long and smooth philtrum, low-set ears, median notch in the upper alveolar ridge, bifid tongue, cutaneous syndactyly of toes 2 and 3, enlarged kidneys and pancreas, arhinencephaly, and partial agenesis of the corpus callosum. We compared the phenotypes of these patients to those previously reported for ring chromosome 13, pure 13q deletions and duplications. We narrowed some critical regions previously reported for lung, kidney and fetal growth, and for thumb, cerebral, and eye anomalies. © 2014 Wiley Periodicals, Inc.

  4. PLD$ is involved in phagocytosis of microglia: expression and localization changes of PLD4 are correlated with activation state of microglia.

    Directory of Open Access Journals (Sweden)

    Yoshinori Otani

    Full Text Available Phospholipase D4 (PLD4 is a recently identified protein that is mainly expressed in the ionized calcium binding adapter molecule 1 (Iba1-positive microglia in the early postnatal mouse cerebellar white matter. Unlike PLD1 and PLD2, PLD4 exhibits no enzymatic activity for conversion of phosphatidylcholine into choline and phosphatidic acid, and its function is completely unknown. In the present study, we examined the distribution of PLD4 in mouse cerebellar white matter during development and under pathological conditions. Immunohistochemical analysis revealed that PLD4 expression was associated with microglial activation under such two different circumstances. A primary cultured microglia and microglial cell line (MG6 showed that PLD4 was mainly present in the nucleus, except the nucleolus, and expression of PLD4 was upregulated by lipopolysaccharide (LPS stimulation. In the analysis of phagocytosis of LPS-stimulated microglia, PLD4 was co-localized with phagosomes that contained BioParticles. Inhibition of PLD4 expression using PLD4 specific small interfering RNA (siRNA in MG6 cells significantly reduced the ratio of phagocytotic cell numbers. These results suggest that the increased PLD4 in the activation process is involved in phagocytosis of activated microglia in the developmental stages and pathological conditions of white matter.

  5. Metals in proteins: correlation between the metal-ion type, coordination number and the amino-acid residues involved in the coordination.

    Science.gov (United States)

    Dokmanić, Ivan; Sikić, Mile; Tomić, Sanja

    2008-03-01

    Metal ions are constituents of many metalloproteins, in which they have either catalytic (metalloenzymes) or structural functions. In this work, the characteristics of various metals were studied (Cu, Zn, Mg, Mn, Fe, Co, Ni, Cd and Ca in proteins with known crystal structure) as well as the specificity of their environments. The analysis was performed on two data sets: the set of protein structures in the Protein Data Bank (PDB) determined with resolution metal ion and its electron donors and the latter was used to assess the preferred coordination numbers and common combinations of amino-acid residues in the neighbourhood of each metal. Although the metal ions considered predominantly had a valence of two, their preferred coordination number and the type of amino-acid residues that participate in the coordination differed significantly from one metal ion to the next. This study concentrates on finding the specificities of a metal-ion environment, namely the distribution of coordination numbers and the amino-acid residue types that frequently take part in coordination. Furthermore, the correlation between the coordination number and the occurrence of certain amino-acid residues (quartets and triplets) in a metal-ion coordination sphere was analysed. The results obtained are of particular value for the identification and modelling of metal-binding sites in protein structures derived by homology modelling. Knowledge of the geometry and characteristics of the metal-binding sites in metalloproteins of known function can help to more closely determine the biological activity of proteins of unknown function and to aid in design of proteins with specific affinity for certain metals.

  6. Interleukin-6 and granulocyte-macrophage colony-stimulating factor in apical periodontitis: correlation with clinical and histologic findings of the involved teeth.

    Science.gov (United States)

    Radics, T; Kiss, C; Tar, I; Márton, I J

    2003-02-01

    Apical periodontitis is characterized by the presence of immunocompetent cells producing a wide variety of inflammatory mediators. Releasing cytokines with long-range action, such as interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF), apical periodontitis may induce changes in remote organs of the host. This study quantified the levels of IL-6 and GM-CSF in symptomatic and asymptomatic human periradicular lesions. Lesions were also characterized by size and histologic findings. Tissue samples were homogenized and supernatants were assayed using an enzyme-linked immunosorbent assay (ELISA). Correlations between cytokine levels and characteristic features (as single variables) of the lesions were analysed. There was a trend for higher levels of IL-6 and GM-CSF in symptomatic than in asymptomatic lesions, but the difference was not significant. Levels also tended to be higher in large than in small lesions, in polymorphonuclear (PMN) cell-rich than in PMN cell-poor samples, and in epithelialized than in non-epithelialized lesions. Significantly higher levels of IL-6 (778.1 +/- 220.5 pg/microg) and GM-CSF (363.3 +/- 98.4 pg/microg) were found in samples coincidentally possessing symptomatic and epithelialized features than in asymptomatic, small, PMN cell-poor, non-epithelialized lesions (IL-6: 45.2 +/- 13.1 pg/microg and GM-CSF: 135.1 +/- 26.4 pg/microg). These results suggest that symptomatic lesions containing epithelial cells represent an immunologically active stage of apical periodontitis, whereas asymptomatic, small, PMN cell-poor, non-epithelialized lesions represent healing apical lesions.

  7. Correlation between vestibular and autonomous function after 6 months of spaceflight: Data of the SPIN and GAZE-SPIN experiments.

    Science.gov (United States)

    Wuyts, Floris; Clement, Gilles; Naumov, Ivan; Kornilova, Ludmila; Glukhikh, Dmitriy; Hallgren, Emma; MacDougall, Hamish; Migeotte, Pierre-Francois; Delière, Quentin; Weerts, Aurelie; Moore, Steven; Diedrich, Andre

    In 13 cosmonauts, the vestibulo-autonomic reflex was investigated before and after 6 months duration spaceflight. Cosmonauts were rotated on the mini-centrifuge VVIS, which is installed in Star City. Initially, this mini-centrifuge flew on board of the Neurolab mission (STS-90), and served to generate intermittent artificial gravity during that mission, with apparent very positive effects on the preservation of the orthostatic tolerance upon return to earth in the 4 crew members that were subjected to the rotations in space. The current experiments SPIN and GAZE-SPIN are control experiments to test the hypothesis that intermittent artificial gravity in space can serve as a counter measure against several deleterious effects of microgravity. Additionally, the effect of microgravity on the gaze holding system is studied as well. Cosmonauts from a long duration stay in the International Space Station were tested on the VVIS (1 g centripetal interaural acceleration; consecutive right-ear-out anti-clockwise and left-ear-out clockwise measurement) on 5 different days. Two measurements were scheduled about one month and a half prior to launch and the remaining three immediately after their return from space (typically on R+2, R+4, R+9; R = return day from space). The ocular counter roll (OCR) as a measure of otolith function was measured on before, during and after the rotation in the mini centrifuge, using infrared video goggles. The perception of verticality was monitored using an ultrasound system. Gaze holding was tested before, during and after rotation. After the centrifugation part, the crew was installed on a tilt table, and instrumented with several cardiovascular recording equipment (ECG, continuous blood pressure monitoring, respiratory monitoring), as well as with impedance measurement devices to investigate fluid redistribution throughout the operational tilt test. To measure heart rate variability parameters, imposed breathing periods were included in the

  8. Three-pion Hanbury Brown-Twiss correlations in relativistic heavy-ion collisions from the STAR experiment.

    Science.gov (United States)

    Adams, J; Adler, C; Ahammed, Z; Allgower, C; Amonett, J; Anderson, B D; Anderson, M; Arkhipkin, D; Averichev, G S; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bichsel, H; Billmeier, A; Bland, L C; Blyth, C O; Bonner, B E; Botje, M; Boucham, A; Brandin, A; Bravar, A; Cadman, R V; Cai, X Z; Caines, H; Calderón de la Barca Sánchez, M; Cardenas, A; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chaloupka, P; Chattopadhyay, S; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Coffin, J P; Cormier, T M; Mora Corral, M; Cramer, J G; Crawford, H J; Derevschikov, A A; Didenko, L; Dietel, T; Draper, J E; Dunin, V B; Dunlop, J C; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Faivre, J; Fatemi, R; Filimonov, K; Finch, E; Fisyak, Y; Flierl, D; Foley, K J; Fu, J; Gagliardi, C A; Gagunashvili, N; Gans, J; Gaudichet, L; Germain, M; Geurts, F; Ghazikhanian, V; Grachov, O; Guedon, M; Guertin, S M; Gushin, E; Gutierrez, T D; Hallman, T J; Hardtke, D; Harris, J W; Heinz, M; Henry, T W; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Humanic, T J; Igo, G; Ishihara, A; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E G; Kabana, S; Kaneta, M; Kaplan, M; Keane, D; Kiryluk, J; Kisiel, A; Klay, J; Klein, S R; Klyachko, A; Kollegger, T; Konstantinov, A S; Kopytine, M; Kotchenda, L; Kovalenko, A D; Kramer, M; Kravtsov, P; Krueger, K; Kuhn, C; Kulikov, A I; Kunde, G J; Kunz, C L; Kutuev, R Kh; Kuznetsov, A A; Lamont, M A C; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lauret, J; Lebedev, A; Lednický, R; Leontiev, V M; LeVine, M J; Li, Q; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, L; Liu, Z; Liu, Q J; Ljubicic, T; Llope, W J; Long, H; Longacre, R S; Lopez-Noriega, M; Love, W A; Ludlam, T; Lynn, D; Ma, J; Ma, Y G; Magestro, D; Majka, R; Margetis, S; Markert, C; Martin, L; Marx, J; Matis, H S; Matulenko, Yu A; McShane, T S; Meissner, F; Melnick, Yu; Meschanin, A; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mitchell, J; Molnar, L; Moore, C F; Morozov, V; de Moura, M M; Munhoz, M G; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Paic, G; Pandey, S U; Panebratsev, Y; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevoztchikov, V; Peryt, W; Petrov, V A; Picha, R; Planinic, M; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potrebenikova, E; Prindle, D; Pruneau, C; Putschke, J; Rai, G; Rakness, G; Ravel, O; Ray, R L; Razin, S V; Reichhold, D; Reid, J G; Renault, G; Retiere, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Rose, A; Roy, C; Rykov, V; Sakrejda, I; Salur, S; Sandweiss, J; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schroeder, L S; Schweda, K; Seger, J; Seyboth, P; Shahaliev, E; Shestermanov, K E; Shimanskii, S S; Simon, F; Skoro, G; Smirnov, N; Snellings, R; Sorensen, P; Sowinski, J; Spinka, H M; Srivastava, B; Stephenson, E J; Stock, R; Stolpovsky, A; Strikhanov, M; Stringfellow, B; Struck, C; Suaide, A A P; Sugarbaker, E; Suire, C; Sumbera, M; Surrow, B; Symons, T J M; Szanto de Toledo, A; Szarwas, P; Tai, A; Takahashi, J; Tang, A H; Thein, D; Thomas, J H; Thompson, M; Timoshenko, S; Tokarev, M; Tonjes, M B; Trainor, T A; Trentalange, S; Tribble, R E; Trofimov, V; Tsai, O; Ullrich, T; Underwood, D G; Van Buren, G; Vander Molen, A M; Vasiliev, A N; Vigdor, S E; Voloshin, S A; Vznuzdaev, M; Wang, F; Wang, Y; Ward, H; Watson, J W; Wells, R; Westfall, G D; Whitten, C; Wieman, H; Willson, R; Wissink, S W; Witt, R; Wood, J; Xu, N; Xu, Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yurevich, V I; Zanevski, Y V; Zborovský, I; Zhang, H; Zhang, W M; Zoulkarneev, R; Zoulkarneeva, J; Zubarev, A N

    2003-12-31

    Data from the first physics run at the Relativistic Heavy-Ion Collider at Brookhaven National Laboratory, Au+Au collisions at sqrt[s(NN)]=130 GeV, have been analyzed by the STAR Collaboration using three-pion correlations with charged pions to study whether pions are emitted independently at freeze-out. We have made a high-statistics measurement of the three-pion correlation function and calculated the normalized three-particle correlator to obtain a quantitative measurement of the degree of chaoticity of the pion source. It is found that the degree of chaoticity seems to increase with increasing particle multiplicity.

  9. Still "at risk": An examination of how street-involved young people understand, experience, and engage with "harm reduction" in Vancouver's inner city.

    Science.gov (United States)

    Bozinoff, Nikki; Small, Will; Long, Cathy; DeBeck, Kora; Fast, Danya

    2017-07-01

    Vancouver is an international leader in implementing interventions to reduce harms related to drug use. However, street-involved young people who use drugs continue to be vulnerable to overdose death, hepatitis C (HCV) infection, and high rates of syringe sharing. To better understand this in the context of the intensive public health response, we examined how young people, who are involved in the 'street drug scene', understood, experienced and engaged with harm reduction. Twelve semi-structured interviews were conducted in 2013 with 13 young people (ages 17-28) recruited from the At-Risk Youth Study, a prospective cohort of street-involved and drug-using young people. These interviews were embedded within a larger, eight-year program of ethnographic research and explored participants' understandings of harm reduction, their use of specific services, and their ideas about improving their day-to-day lives. Interviews were transcribed verbatim and a thematic analysis was performed. Young peoples' ideas about harm reduction were diverse and expansive. They articulated the limitations of existing programs, indicating that while they are positioned to reduce the risk of HIV and HCV transmission, they offer little meaningful support to improve young peoples' broader life chances. Young people described strategies to mitigate risk and harm in their own lives, including transitioning to drugs deemed less harmful and attempting to gain access to drug treatment. Finally, young people indicated that spatial considerations (e.g., distance from Vancouver's Downtown Eastside) strongly determined access to services. In Vancouver, a large, well established harm reduction infrastructure seeks to reduce HIV and HCV transmission among street-involved young people. However, young peoples' multiple understandings, experiences and engagements with harm reduction in this setting illustrate the limitations of the existing infrastructure in improving their broader life chances. Copyright

  10. The LPCTrap experiment: measurement of the {beta}-{nu} angular correlation in {sup 6}He{sup +} decay using a transparent Paul trap

    Energy Technology Data Exchange (ETDEWEB)

    Velten, Ph., E-mail: velten@lpccaen.in2p3.fr; Ban, G.; Durand, D.; Flechard, X.; Lienard, E.; Mauger, F.; Mery, A.; Naviliat-Cuncic, O.; Rodriguez, D.; Thomas, J. C. [Universite de Caen, LPC Caen, ENSICAEN (France)

    2011-07-15

    The LPCTrap experiment is devoted to the precise measurement of the {beta}-{nu} angular correlation parameter, a{sub {beta}{nu}}, in the pure Gamow-Teller decay of {sup 6}He{sup +}. This experiment is motivated by the search of the presence of tensor type contributions in the weak interaction. The radioactive source is confined in a transparent Paul trap installed at LIRAT, the low energy beam line of the SPIRAL facility. The {beta}-{nu} correlation is studied by measuring the time of flight of the recoil ions detected in coincidence with the {beta} particles. During the last experiment, a total of 4 Multiplication-Sign 10{sup 6} coincidence events have been recorded which would enable to determine the coefficient with a statistical uncertainty of 0.5%. The status of the analysis is presented in this contribution.

  11. aCORN: An experiment to measure the electron-antineutrino correlation coefficient in free neutron decay.

    Science.gov (United States)

    Collett, B; Bateman, F; Bauder, W K; Byrne, J; Byron, W A; Chen, W; Darius, G; DeAngelis, C; Dewey, M S; Gentile, T R; Hassan, M T; Jones, G L; Komives, A; Laptev, A; Mendenhall, M P; Nico, J S; Noid, G; Park, H; Stephenson, E J; Stern, I; Stockton, K J S; Trull, C; Wietfeldt, F E; Yerozolimsky, B G

    2017-08-01

    We describe an apparatus used to measure the electron-antineutrino angular correlation coefficient in free neutron decay. The apparatus employs a novel measurement technique in which the angular correlation is converted into a proton time-of-flight asymmetry that is counted directly, avoiding the need for proton spectroscopy. Details of the method, apparatus, detectors, data acquisition, and data reduction scheme are presented, along with a discussion of the important systematic effects.

  12. How parents and practitioners experience research without prior consent (deferred consent) for emergency research involving children with life threatening conditions: a mixed method study.

    Science.gov (United States)

    Woolfall, Kerry; Frith, Lucy; Gamble, Carrol; Gilbert, Ruth; Mok, Quen; Young, Bridget

    2015-09-18

    Alternatives to prospective informed consent to enable children with life-threatening conditions to be entered into trials of emergency treatments are needed. Across Europe, a process called deferred consent has been developed as an alternative. Little is known about the views and experiences of those with first-hand experience of this controversial consent process. To inform how consent is sought for future paediatric critical care trials, we explored the views and experiences of parents and practitioners involved in the CATheter infections in CHildren (CATCH) trial, which allowed for deferred consent in certain circumstances. Mixed method survey, interview and focus group study. 275 parents completed a questionnaire; 20 families participated in an interview (18 mothers, 5 fathers). 17 CATCH practitioners participated in one of four focus groups (10 nurses, 3 doctors and 4 clinical trial unit staff). 12 UK children's hospitals. Some parents were momentarily shocked or angered to discover that their child had or could have been entered into CATCH without their prior consent. Although these feelings resolved after the reasons why consent needed to be deferred were explained and that the CATCH interventions were already used in clinical care. Prior to seeking deferred consent for the first few times, CATCH practitioners were apprehensive, although their feelings abated with experience of talking to parents about CATCH. Parents reported that their decisions about their child's participation in the trial had been voluntary. However, mistiming the deferred consent discussion had caused distress for some. Practitioners and parents supported the use of deferred consent in CATCH and in future trials of interventions already used in clinical care. Our study provides evidence to support the use of deferred consent in paediatric emergency medicine; it also indicates the crucial importance of practitioner communication and appropriate timing of deferred consent discussions

  13. How parents and practitioners experience research without prior consent (deferred consent) for emergency research involving children with life threatening conditions: a mixed method study

    Science.gov (United States)

    Woolfall, Kerry; Frith, Lucy; Gamble, Carrol; Gilbert, Ruth; Mok, Quen; Young, Bridget

    2015-01-01

    Objective Alternatives to prospective informed consent to enable children with life-threatening conditions to be entered into trials of emergency treatments are needed. Across Europe, a process called deferred consent has been developed as an alternative. Little is known about the views and experiences of those with first-hand experience of this controversial consent process. To inform how consent is sought for future paediatric critical care trials, we explored the views and experiences of parents and practitioners involved in the CATheter infections in CHildren (CATCH) trial, which allowed for deferred consent in certain circumstances. Design Mixed method survey, interview and focus group study. Participants 275 parents completed a questionnaire; 20 families participated in an interview (18 mothers, 5 fathers). 17 CATCH practitioners participated in one of four focus groups (10 nurses, 3 doctors and 4 clinical trial unit staff). Setting 12 UK children's hospitals. Results Some parents were momentarily shocked or angered to discover that their child had or could have been entered into CATCH without their prior consent. Although these feelings resolved after the reasons why consent needed to be deferred were explained and that the CATCH interventions were already used in clinical care. Prior to seeking deferred consent for the first few times, CATCH practitioners were apprehensive, although their feelings abated with experience of talking to parents about CATCH. Parents reported that their decisions about their child's participation in the trial had been voluntary. However, mistiming the deferred consent discussion had caused distress for some. Practitioners and parents supported the use of deferred consent in CATCH and in future trials of interventions already used in clinical care. Conclusions Our study provides evidence to support the use of deferred consent in paediatric emergency medicine; it also indicates the crucial importance of practitioner communication

  14. Four years of experience with the use of calculated isotopic correlations in establishing input balances at the La Hague plant

    International Nuclear Information System (INIS)

    Aries, M.; Patigny, P.; Bouchard, J.; Giacometti, A.; Girieud, R.

    1983-01-01

    For more than four years the La Hague reprocessing plant has been using calculated isotopic correlations to establish and check its input balances. The masses of uranium and plutonium entering the plant are determined by the gravimetric balance method, which utilizes the burnup obtained by calculated isotopic correlation as well as the Pu/U ratio measured at the dissolver after cross-checking with the values obtained by correlation. Further, a verification of all the parameters needed to establish these balances - whether physical or chemical in origin - is carried out systematically by means of internal coherence constants which make it possible to detect any anomalies in the dissolution data. The calculated isotopic correlations were evaluated when the analyses of numerous representative samples of irradiated fuel and experimental results of separated isotopic irradiation in water reactor spectra had been interpreted. The accuracy achieved was improved by allowing in the neutron calculations for effects inherent in the first reactor core and by selecting a set of calculation functions which attenuates (by compensation effects) the various perturbations in the irradiation history. The results obtained at La Hague with calculated isotopic correlations on nearly 600 t of reprocessed UO 2 , because of their large number and above all their high quality, suggest that it be proposed extending the method to other reprocessing plants. This could be done by the operator himself or by national or international control bodies within the framework of a safeguards arrangement. (author)

  15. Correlated alpha activity with the facial expression processing network in a simultaneous EEG-fMRI experiment.

    Science.gov (United States)

    Simoes, Marco; Direito, Bruno; Lima, Joao; Castelhano, Joao; Ferreira, Carlos; Couceiro, Ricardo; Carvalho, Paulo; Castelo-Branco, Miguel

    2017-07-01

    The relationship between EEG and fMRI data is poorly covered in the literature. Extensive work has been conducted in resting-state and epileptic activity, highlighting a negative correlation between the alpha power band of the EEG and the BOLD activity in the default-mode-network. The identification of an appropriate task-specific relationship between fMRI and EEG data for predefined regions-of-interest, would allow the transfer of interventional paradigms (such as BOLD-based neurofeedback sessions) from fMRI to EEG, enhancing its application range by lowering its costs and improving its flexibility. In this study, we present an analysis of the correlation between task-specific alpha band fluctuations and BOLD activity in the facial expressions processing network. We characterized the network ROIs through a stringent localizer and identified two clusters on the scalp (one frontal, one parietal-occipital) with marked alpha fluctuations, related to the task. We then check whether such power variations throughout the time correlate with the BOLD activity in the network. Our results show statistically significant negative correlations between the alpha power in both clusters and for all the ROIs of the network. The correlation levels have still not met the requirements for transferring the protocol to an EEG setup, but they pave the way towards a better understand on how frontal and parietal-occipital alpha relates to the activity of the facial expressions processing network.

  16. Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal.

    Science.gov (United States)

    Terwilliger, Thomas C; Bunkóczi, Gábor; Hung, Li Wei; Zwart, Peter H; Smith, Janet L; Akey, David L; Adams, Paul D

    2016-03-01

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Here, algorithms and tools for evaluating and optimizing the useful anomalous correlation and the anomalous signal in a SAD experiment are described. A simple theoretical framework [Terwilliger et al. (2016), Acta Cryst. D72, 346-358] is used to develop methods for planning a SAD experiment, scaling SAD data sets and estimating the useful anomalous correlation and anomalous signal in a SAD data set. The phenix.plan_sad_experiment tool uses a database of solved and unsolved SAD data sets and the expected characteristics of a SAD data set to estimate the probability that the anomalous substructure will be found in the SAD experiment and the expected map quality that would be obtained if the substructure were found. The phenix.scale_and_merge tool scales unmerged SAD data from one or more crystals using local scaling and optimizes the anomalous signal by identifying the systematic differences among data sets, and the phenix.anomalous_signal tool estimates the useful anomalous correlation and anomalous signal after collecting SAD data and estimates the probability that the data set can be solved and the likely figure of merit of phasing.

  17. An Intervention to Improve Teachers' Interpersonally Involving Instructional Practices in High School Physical Education: Implications for Student Relatedness Support and In-Class Experiences.

    Science.gov (United States)

    Sparks, Cassandra; Lonsdale, Chris; Dimmock, James; Jackson, Ben

    2017-04-01

    Research grounded in self-determination theory has demonstrated the important role of teachers in shaping students' physical education experiences. Utilizing a cluster-randomized controlled design, this study aimed to examine whether an interpersonally involving training program based on self-determination theory principles could enhance students' in-class experiences. With 18 teachers (males = 8, females = 10, M age  = 32.75, SD = 8.14) and a final sample of 382 students (males = 155, females = 227, M age  = 13.20, SD = 1.66), we implemented linear mixed modeling to investigate the effects on students' (a) perceived relatedness support and (b) enjoyment of physical education, tripartite efficacy beliefs (i.e., self-efficacy, other-efficacy, relation-inferred self-efficacy), self-determined motivation, and amotivation. Relative to those in the control condition, students in the treatment condition reported positive changes in teacher-provided relatedness support, enjoyment, other-efficacy, and peer-focused relation-inferred self-efficacy. These findings demonstrate support for strategies designed to aid physical education teachers' relatedness-supportive instructional behaviors.

  18. The intraclass correlation coefficient applied for evaluation of data correction, labeling methods and rectal biopsy sampling in DNA microarray experiments

    NARCIS (Netherlands)

    Pellis, E.P.M.; Franssen-Hal, van N.L.W.; Burema, J.; Keijer, J.

    2003-01-01

    We show that the intraclass correlation coefficient (ICC) can be used as a relatively simple statistical measure to assess methodological and biological variation in DNA microarray analysis. The ICC is a measure that determines the reproducibility of a variable, which can easily be calculated from

  19. Correlation of six minute walk test with spirometric indices in chronic obstructive pulmonary disease patients: A tertiary care hospital experience

    Directory of Open Access Journals (Sweden)

    Abhijit Kundu

    2015-01-01

    Full Text Available Background: Six-minute walk test (6MWT is a simple, objective, reproducible test which correlated well with different spirometric indices, and thus able to predict severity of chronic obstructive pulmonary disease (COPD and can replace spirometry in resource poor set-up. Aims and Objectives: To find out correlation between spirometric indices (forced expiratory volume in 1 s (FEV 1 , forced vital capacity (FVC, and peak expiratory flow rate (PEFR and 6-minute walk distance (6MWD in COPD patients, and thus to assess whether 6MWT can replace spirometry. Settings and Design: Institution based cross-sectional observational study. Materials and Methods: Eighty patients of COPD (diagnosis confirmed by Global Initiative for Chronic Obstructive Lung Disease (GOLD 2010 criteria were enrolled for the study after applying exclusion criteria. All patients underwent spirometric measurement of FEV 1 , FVC, PEFR, and ratio of FEV 1 and FVC and test repeated after bronchodilation by 200-400 μg of salbutamol. 6MWT was performed following American Thoracic Society (ATS protocol of 6MWT and distance was measured in meters. Results: We found significant linear correlation of 6MWT with post-FEV 1 (r = 0.478, P < 0.001, post-FVC (r = 0.454, P < 0.001, and post-PEFR (r = 0.408, P < 0.001, but no correlation with FEV 1 /FVC (r = 0.250, P = 0.025. We also found significant correlation of 6MWT with BODE (body mass index (BMI, airway obstruction, dyspnea, and exercise capacity index (r = −0.419, P < 0.001. Conclusions: 6MWT can be a useful replacement of spirometry in assessment of severity of COPD.

  20. Squaring Up: Experiences of Transition from Off-Street Sex Work to Square Work and Duality--Concurrent Involvement in Both--in Vancouver, BC.

    Science.gov (United States)

    Bowen, Raven R

    2015-11-01

    Many studies of exit from sex work are inspired by role theory, where people experience a lack of attachment to a role; are faced with individual, interactional, and structural challenges; contemplate transition and exit a role; and then struggle to establish postrole identities and new lives. This framework has been used to explicate the factors and experiences of those who leave or attempt to leave the sex industry; however, it is limited because studies present sex work as a harmful and dangerous profession that people are trapped in, escaping, or have survived. In this paper, I discuss Vancouver's history of violence against sex workers and I review research on sex work exiting and bring forward recommendations for the design of exit program based on the experiences of 22 active and former off-street sex workers from Vancouver, British Columbia. I describe study participants who include Sex-Work-No-More participants who would not return to the industry, Sex-Work-Maybe participants who consider reinvolvement, and Dual-Life participants who are employed in sex work and conventional work simultaneously. These participants uniquely challenge narrow, binary understandings of involvement and transition because they discuss their use of deception to obtain resources needed to make change; the support that clients have provided; their strategic engagement in sex work as a means to exit; their considerations of reentry; and for some, their dual employment. In light of new legislation that criminalizes activities related to sex work-the Protection of Communities and Exploited Persons Act-and the Federal government announcement of $20 million dollars for the creation of exit services nationwide, hearing from sex workers is essential to advancing agendas in this area. © 2015 Canadian Sociological Association/La Société canadienne de sociologie.

  1. Isolated photon-hadron correlations in proton-proton collisions at {\\sqrt(s)} = 7 TeV with the ALICE experiment

    CERN Document Server

    Arbor, Nicolas

    2013-01-01

    At high pT, direct photons produced in Compton and annihilation QCD leading order processes are associated to a jet in the opposite direction. Such processes are tagged experimentally by identifying leading isolated photons and their correlated associated hadrons in the opposite azimuthal direction. The jet fragmentation can be estimated from the hadrons and the photon via the imbalance parameter xE. We present the results extracted from gamma-hadron correlations measured by the ALICE experiment in pp collisions at {\\sqrt(s)} = 7 TeV. Direct photons are first identified using isolated criteria. Then, the remaining contamination from neutral mesons decay photons is subtracted statistically to extract the xE distributions of isolated photon-hadron and isolated {\\pi}^0-hadron correlations.

  2. Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.

    Science.gov (United States)

    Hook, Lauren M; Cairns, Tina M; Awasthi, Sita; Brooks, Benjamin D; Ditto, Noah T; Eisenberg, Roselyn J; Cohen, Gary H; Friedman, Harvey M

    2018-05-01

    Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is to produce antibodies that block crucial gD2 epitopes involved in virus entry and cell-to-cell spread. HSV-2 gD2 was the only antigen in the Herpevac Trial for Women that protected against HSV-1 genital infection but not HSV-2. In that trial, a correlation was detected between gD2 ELISA titers and protection against HSV-1, supporting the importance of antibodies. A possible explanation for the lack of protection against HSV-2 was that HSV-2 neutralization titers were low, four-fold lower than to HSV-1. Here, we evaluated neutralization titers and epitope-specific antibody responses to crucial gD2 epitopes involved in virus entry and cell-to-cell spread as correlates of immune protection against genital lesions in immunized guinea pigs. We detected a strong correlation between neutralizing antibodies and protection against genital disease. We used a high throughput biosensor competition assay to measure epitope-specific responses to seven crucial gD2 linear and conformational epitopes involved in virus entry and spread. Some animals produced antibodies to most crucial epitopes while others produced antibodies to few. The number of epitopes recognized by guinea pig immune serum correlated with protection against genital lesions. We confirmed the importance of antibodies to each crucial epitope using monoclonal antibody passive transfer that improved survival and reduced genital disease in mice after HSV-2 genital challenge. We re-evaluated our prior study of epitope-specific antibody responses in women in the Herpevac Trial. Humans produced antibodies that blocked significantly fewer crucial gD2 epitopes than guinea pigs, and antibody responses in humans to some linear epitopes were virtually absent. Neutralizing antibody titers and epitope-specific antibody responses are important immune parameters to

  3. Bose-Einstein correlations in charged current muon-neutrino interactions in the NOMAD experiment at CERN

    International Nuclear Information System (INIS)

    Astier, P.; Autiero, D.; Baldisseri, A.; Baldo-Ceolin, M.; Banner, M.; Bassompierre, G.; Benslama, K.; Besson, N.; Bird, I.; Blumenfeld, B.; Bobisut, F.; Bouchez, J.; Boyd, S.; Bueno, A.; Bunyatov, S.; Camilleri, L.; Cardini, A.; Cattaneo, P.W.; Cavasinni, V.; Cervera-Villanueva, A.; Challis, R.C.; Chukanov, A.; Collazuol, G.; Conforto, G.; Conta, C.; Contalbrigo, M.; Cousins, R.; Daniels, D.; Degaudenzi, H.; Del Prete, T.; De Santo, A.; Dignan, T.; Di Lella, L.; Couto e Silva, E. do; Dumarchez, J.; Ellis, M.; Feldman, G.J.; Ferrari, R.; Ferrere, D.; Flaminio, V.; Fraternali, M.; Gaillard, J.-M.; Gangler, E.; Geiser, A.; Geppert, D.; Gibin, D.; Gninenko, S.; Godley, A.; Gomez-Cadenas, J.-J.; Gosset, J.; Goessling, C.; Gouanere, M.; Grant, A.; Graziani, G.; Guglielmi, A.; Hagner, C.; Hernando, J.; Hubbard, D.; Hurst, P.; Hyett, N.; Iacopini, E.; Joseph, C.; Juget, F.; Kent, N.; Kirsanov, M.; Klimov, O.; Kokkonen, J.; Kovzelev, A.; Krasnoperov, A.; Lacaprara, S.; Lachaud, C.; Lakic, B.; Lanza, A.; La Rotonda, L.; Laveder, M.; Letessier-Selvon, A.; Levy, J.-M.; Linssen, L.; Ljubicic, A.; Long, J.; Lupi, A.; Lyubushkin, V.; Marchionni, A.; Martelli, F.; Mechain, X.; Mendiburu, J.-P.; Meyer, J.-P.; Mezzetto, M.; Mishra, S.R.; Moorhead, G.F.; Naumov, D.; Nedelec, P.; Nefedov, Yu.; Nguyen-Mau, C.; Orestano, D.; Pastore, F.; Peak, L.S.; Pennacchio, E.; Pessard, H.; Petti, R.; Placci, A.; Polesello, G.; Pollmann, D.; Polyarush, A.; Popov, B.; Poulsen, C.; Rebuffi, L.; Rico, J.; Riemann, P.; Roda, C.; Rubbia, A.; Salvatore, F.; Schahmaneche, K.; Schmidt, B.; Schmidt, T.; Sconza, A.; Sevior, M.; Sillou, D.; Soler, F.J.P.; Sozzi, G.; Steele, D.; Stiegler, U.; Stipcevic, M.; Stolarczyk, Th.; Tareb-Reyes, M.; Taylor, G.N.; Tereshchenko, V.; Toropin, A.; Touchard, A.-M.; Tovey, S.N.; Tran, M.-T.; Tsesmelis, E.; Ulrichs, J.; Vacavant, L.; Valdata-Nappi, M.; Valuev, V.; Vannucci, F.; Varvell, K.E.; Veltri, M.; Vercesi, V.; Vidal-Sitjes, G.; Vieira, J.-M.; Vinogradova, T.; Weber, F.V.; Weisse, T.; Wilson, F.F.; Winton, L.J.; Yabsley, B.D.; Zaccone, H.; Zei, R.; Zuber, K.; Zuccon, P.

    2004-01-01

    Bose-Einstein correlations in one and two dimensions have been studied, with high statistics, in charged current muon-neutrino interaction events collected with the NOMAD detector at CERN. In one dimension the Bose-Einstein effect has been analyzed with the Goldhaber and the Kopylov-Podgoretskii phenomenological parametrizations. The Goldhaber parametrization gives the radius of the pion emission region R G =1.01±0.05(stat) +0.09 -0.06 (sys) fm and for the chaoticity parameter the value λ=0.40±0.03(stat) +0.01 -0.06 (sys). Using the Kopylov-Podgoretskii parametrization yields R KP =2.07±0.04(stat) +0.01 -0.14 (sys) fm and λ KP =0.29±0.06(stat) +0.01 -0.04 (sys). Different parametrizations of the long-range correlations have been also studied. The two-dimensional shape of the source has been investigated in the longitudinal comoving frame. A significant difference between the transverse and the longitudinal dimensions is observed. The high statistics of the collected sample allowed the study of the Bose-Einstein correlations as a function of rapidity, charged particle multiplicity and hadronic energy. A weak dependence of both radius and chaoticity on multiplicity and hadronic energy is found

  4. Analysis of fatty infiltration and inflammation of the pelvic and thigh muscles in boys with Duchenne muscular dystrophy (DMD): grading of disease involvement on MR imaging and correlation with clinical assessments.

    Science.gov (United States)

    Kim, Hee Kyung; Merrow, Arnold C; Shiraj, Sahar; Wong, Brenda L; Horn, Paul S; Laor, Tal

    2013-10-01

    Prior reports focus primarily on muscle fatty infiltration in Duchenne muscular dystrophy (DMD). However, the significance of muscle edema is uncertain. To evaluate the frequency and degree of muscle fat and edema, and correlate these with clinical function. Forty-two boys (ages 5-19 years) with DMD underwent pelvic MRI. Axial T1- and fat-suppressed T2-weighted images were evaluated to grade muscle fatty infiltration (0-4) and edema (0-3), respectively. Degree and frequency of disease involvement were compared to clinical evaluations. Gluteus maximus had the greatest mean fatty infiltration score, followed by adductor magnus and gluteus medius muscles, and had the most frequent and greatest degree of fatty infiltration. Gluteus maximus also had the greatest mean edema score, followed by vastus lateralis and gluteus medius muscles. These muscles had the most frequent edema, although the greatest degree of edema was seen in other muscles. There was correlation between cumulative scores of fatty infiltration and all clinical evaluations (P muscles with the most frequent fatty infiltration had the greatest degree of fatty infiltration and correlated with patient function. However, the muscles with the most frequent edema were different from those with the greatest degree of edema. Thus, edema may not predict patient functional status.

  5. PET-CT-Based Auto-Contouring in Non-Small-Cell Lung Cancer Correlates With Pathology and Reduces Interobserver Variability in the Delineation of the Primary Tumor and Involved Nodal Volumes

    International Nuclear Information System (INIS)

    Baardwijk, Angela van; Bosmans, Geert; Boersma, Liesbeth; Buijsen, Jeroen; Wanders, Stofferinus; Hochstenbag, Monique; Suylen, Robert-Jan van; Dekker, Andre; Dehing-Oberije, Cary; Houben, Ruud; Bentzen, Soren M.; Kroonenburgh, Marinus van; Lambin, Philippe; Ruysscher, Dirk de

    2007-01-01

    Purpose: To compare source-to-background ratio (SBR)-based PET-CT auto-delineation with pathology in non-small-cell lung cancer (NSCLC) and to investigate whether auto-delineation reduces the interobserver variability compared with manual PET-CT-based gross tumor volume (GTV) delineation. Methods and Materials: Source-to-background ratio-based auto-delineation was compared with macroscopic tumor dimensions to assess its validity in 23 tumors. Thereafter, GTVs were delineated manually on 33 PET-CT scans by five observers for the primary tumor (GTV-1) and the involved lymph nodes (GTV-2). The delineation was repeated after 6 months with the auto-contour provided. This contour was edited by the observers. For comparison, the concordance index (CI) was calculated, defined as the ratio of intersection and the union of two volumes (A intersection B)/(A union B). Results: The maximal tumor diameter of the SBR-based auto-contour correlated strongly with the macroscopic diameter of primary tumors (correlation coefficient = 0.90) and was shown to be accurate for involved lymph nodes (sensitivity 67%, specificity 95%). The median auto-contour-based target volumes were smaller than those defined by manual delineation for GTV-1 (31.8 and 34.6 cm 3 , respectively; p = 0.001) and GTV-2 (16.3 and 21.8 cm 3 , respectively; p 0.02). The auto-contour-based method showed higher CIs than the manual method for GTV-1 (0.74 and 0.70 cm 3 , respectively; p 3 , respectively; p = 0.11). Conclusion: Source-to-background ratio-based auto-delineation showed a good correlation with pathology, decreased the delineated volumes of the GTVs, and reduced the interobserver variability. Auto-contouring may further improve the quality of target delineation in NSCLC patients

  6. $K^{0}_{s}-K^{0}_{s}$ correlations in pp collisions at $\\sqrt{s}=7 TeV$ from the LHC ALICE experiment

    CERN Document Server

    Abelev, Betty; Adamova, Dagmar; Adare, Andrew Marshall; Aggarwal, Madan; Aglieri Rinella, Gianluca; Agocs, Andras Gabor; Agostinelli, Andrea; Aguilar Salazar, Saul; Ahammed, Zubayer; Ahmad, Arshad; Ahmad, Nazeer; Ahn, Sang Un; Akindinov, Alexander; Aleksandrov, Dmitry; Alessandro, Bruno; Alfaro Molina, Jose Ruben; Alici, Andrea; Alkin, Anton; Almaraz Avina, Erick Jonathan; Alme, Johan; Alt, Torsten; Altini, Valerio; Altinpinar, Sedat; Altsybeev, Igor; Andrei, Cristian; Andronic, Anton; Anguelov, Venelin; Anielski, Jonas; Anticic, Tome; Antinori, Federico; Antonioli, Pietro; Aphecetche, Laurent Bernard; Appelshauser, Harald; Arbor, Nicolas; Arcelli, Silvia; Armesto, Nestor; Arnaldi, Roberta; Aronsson, Tomas Robert; Arsene, Ionut Cristian; Arslandok, Mesut; Augustinus, Andre; Averbeck, Ralf Peter; Awes, Terry; Aysto, Juha Heikki; Azmi, Mohd Danish; Bach, Matthias Jakob; Badala, Angela; Baek, Yong Wook; Bailhache, Raphaelle Marie; Bala, Renu; Baldini Ferroli, Rinaldo; Baldisseri, Alberto; Baldit, Alain; Baltasar Dos Santos Pedrosa, Fernando; Ban, Jaroslav; Baral, Rama Chandra; Barbera, Roberto; Barile, Francesco; Barnafoldi, Gergely Gabor; Barnby, Lee Stuart; Barret, Valerie; Bartke, Jerzy Gustaw; Basile, Maurizio; Bastid, Nicole; Basu, Sumit; Bathen, Bastian; Batigne, Guillaume; Batyunya, Boris; Baumann, Christoph Heinrich; Bearden, Ian Gardner; Beck, Hans; Behera, Nirbhay Kumar; Belikov, Iouri; Bellini, Francesca; Bellwied, Rene; Belmont-Moreno, Ernesto; Bencedi, Gyula; Beole, Stefania; Berceanu, Ionela; Bercuci, Alexandru; Berdnikov, Yaroslav; Berenyi, Daniel; Bergognon, Anais Annick Erica; Berzano, Dario; Betev, Latchezar; Bhasin, Anju; Bhati, Ashok Kumar; Bhom, Jihyun; Bianchi, Livio; Bianchi, Nicola; Bianchin, Chiara; Bielcik, Jaroslav; Bielcikova, Jana; Bilandzic, Ante; Bjelogrlic, Sandro; Blanco, F; Blanco, Francesco; Blau, Dmitry; Blume, Christoph; Bock, Nicolas; Boettger, Stefan; Bogdanov, Alexey; Boggild, Hans; Bogolyubsky, Mikhail; Boldizsar, Laszlo; Bombara, Marek; Book, Julian; Borel, Herve; Borissov, Alexander; Bose, Suvendu Nath; Bossu, Francesco; Botje, Michiel; Boyer, Bruno Alexandre; Braidot, Ermes; Braun-Munzinger, Peter; Bregant, Marco; Breitner, Timo Gunther; Browning, Tyler Allen; Broz, Michal; Brun, Rene; Bruna, Elena; Bruno, Giuseppe Eugenio; Budnikov, Dmitry; Buesching, Henner; Bufalino, Stefania; Bugaiev, Kyrylo; Busch, Oliver; Buthelezi, Edith Zinhle; Caffarri, Davide; Cai, Xu; Caines, Helen Louise; Calvo Villar, Ernesto; Camerini, Paolo; Canoa Roman, Veronica; Cara Romeo, Giovanni; Carena, Francesco; Carena, Wisla; Carminati, Federico; Casanova Diaz, Amaya Ofelia; Castillo Castellanos, Javier Ernesto; Casula, Ester Anna Rita; Catanescu, Vasile; Cavicchioli, Costanza; Ceballos Sanchez, Cesar; Cepila, Jan; Cerello, Piergiorgio; Chang, Beomsu; Chapeland, Sylvain; Charvet, Jean-Luc Fernand; Chattopadhyay, Sukalyan; Chattopadhyay, Subhasis; Chawla, Isha; Cherney, Michael Gerard; Cheshkov, Cvetan; Cheynis, Brigitte; Chiavassa, Emilio; Chibante Barroso, Vasco Miguel; Chinellato, David; Chochula, Peter; Chojnacki, Marek; Choudhury, Subikash; Christakoglou, Panagiotis; Christensen, Christian Holm; Christiansen, Peter; Chujo, Tatsuya; Chung, Suh-Urk; Cicalo, Corrado; Cifarelli, Luisa; Cindolo, Federico; Cleymans, Jean Willy Andre; Coccetti, Fabrizio; Colamaria, Fabio; Colella, Domenico; Conesa Balbastre, Gustavo; Conesa del Valle, Zaida; Constantin, Paul; Contin, Giacomo; Contreras, Jesus Guillermo; Cormier, Thomas Michael; Corrales Morales, Yasser; Cortes Maldonado, Ismael; Cortese, Pietro; Cosentino, Mauro Rogerio; Costa, Filippo; Cotallo, Manuel Enrique; Crochet, Philippe; Cruz Alaniz, Emilia; Cuautle, Eleazar; Cunqueiro, Leticia; D'Erasmo, Ginevra; Dainese, Andrea; Dalsgaard, Hans Hjersing; Danu, Andrea; Das, Debasish; Das, Indranil; Das, Kushal; Dash, Ajay Kumar; Dash, Sadhana; De, Sudipan; de Barros, Gabriel; De Caro, Annalisa; de Cataldo, Giacinto; de Cuveland, Jan; De Falco, Alessandro; De Gruttola, Daniele; De Marco, Nora; De Pasquale, Salvatore; de Rooij, Raoul Stefan; Delagrange, Hugues; Deloff, Andrzej; Demanov, Vyacheslav; Denes, Ervin; Deppman, Airton; Di Bari, Domenico; Di Giglio, Carmelo; Di Liberto, Sergio; Di Mauro, Antonio; Di Nezza, Pasquale; Diaz Corchero, Miguel Angel; Dietel, Thomas; Divia, Roberto; Djuvsland, Oeystein; Dobrin, Alexandru Florin; Dobrowolski, Tadeusz Antoni; Dominguez, Isabel; Donigus, Benjamin; Dordic, Olja; Driga, Olga; Dubey, Anand Kumar; Ducroux, Laurent; Dupieux, Pascal; Dutta Majumdar, AK; Dutta Majumdar, Mihir Ranjan; Elia, Domenico; Emschermann, David Philip; Engel, Heiko; Erdal, Hege Austrheim; Espagnon, Bruno; Estienne, Magali Danielle; Esumi, Shinichi; Evans, David; Eyyubova, Gyulnara; Fabris, Daniela; Faivre, Julien; Falchieri, Davide; Fantoni, Alessandra; Fasel, Markus; Fedunov, Anatoly; Fehlker, Dominik; Feldkamp, Linus; Felea, Daniel; Fenton-Olsen, Bo; Feofilov, Grigory; Fernandez Tellez, Arturo; Ferretti, Alessandro; Ferretti, Roberta; Figiel, Jan; Figueredo, Marcel; Filchagin, Sergey; Finogeev, Dmitry; Fionda, Fiorella; Fiore, Enrichetta Maria; Floris, Michele; Foertsch, Siegfried Valentin; Foka, Panagiota; Fokin, Sergey; Fragiacomo, Enrico; Frankenfeld, Ulrich Michael; Fuchs, Ulrich; Furget, Christophe; Fusco Girard, Mario; Gaardhoje, Jens Joergen; Gagliardi, Martino; Gago, Alberto; Gallio, Mauro; Gangadharan, Dhevan Raja; Ganoti, Paraskevi; Garabatos, Jose; Garcia-Solis, Edmundo; Garishvili, Irakli; Gerhard, Jochen; Germain, Marie; Geuna, Claudio; Gheata, Andrei George; Gheata, Mihaela; Ghidini, Bruno; Ghosh, Premomoy; Gianotti, Paola; Girard, Martin Robert; Giubellino, Paolo; Gladysz-Dziadus, Ewa; Glassel, Peter; Gomez, Ramon; Gonschior, Alexey; Gonzalez Ferreiro, Elena; Gonzalez-Trueba, Laura Helena; Gonzalez-Zamora, Pedro; Gorbunov, Sergey; Goswami, Ankita; Gotovac, Sven; Grabski, Varlen; Graczykowski, Lukasz Kamil; Grajcarek, Robert; Grelli, Alessandro; Grigoras, Alina Gabriela; Grigoras, Costin; Grigoriev, Vladislav; Grigoryan, Ara; Grigoryan, Smbat; Grinyov, Boris; Grion, Nevio; Grosse-Oetringhaus, Jan Fiete; Grossiord, Jean-Yves; Grosso, Raffaele; Guber, Fedor; Guernane, Rachid; Guerra Gutierrez, Cesar; Guerzoni, Barbara; Guilbaud, Maxime Rene Joseph; Gulbrandsen, Kristjan Herlache; Gunji, Taku; Gupta, Anik; Gupta, Ramni; Gutbrod, Hans; Haaland, Oystein Senneset; Hadjidakis, Cynthia Marie; Haiduc, Maria; Hamagaki, Hideki; Hamar, Gergoe; Hanratty, Luke David; Hansen, Alexander; Harmanova, Zuzana; Harris, John William; Hartig, Matthias; Hasegan, Dumitru; Hatzifotiadou, Despoina; Hayrapetyan, Arsen; Heckel, Stefan Thomas; Heide, Markus Ansgar; Helstrup, Haavard; Herghelegiu, Andrei Ionut; Herrera Corral, Gerardo Antonio; Herrmann, Norbert; Hess, Benjamin Andreas; Hetland, Kristin Fanebust; Hicks, Bernard; Hille, Per Thomas; Hippolyte, Boris; Horaguchi, Takuma; Hori, Yasuto; Hristov, Peter Zahariev; Hrivnacova, Ivana; Huang, Meidana; Humanic, Thomas; Hwang, Dae Sung; Ichou, Raphaelle; Ilkaev, Radiy; Ilkiv, Iryna; Inaba, Motoi; Incani, Elisa; Innocenti, Gian Michele; Ippolitov, Mikhail; Irfan, Muhammad; Ivan, Cristian George; Ivanov, Andrey; Ivanov, Marian; Ivanov, Vladimir; Ivanytskyi, Oleksii; Jacholkowski, Adam Wlodzimierz; Jacobs, Peter; Jangal, Swensy Gwladys; Janik, Malgorzata Anna; Janik, Rudolf; Jayarathna, Sandun; Jena, Satyajit; Jha, Deeptanshu Manu; Jimenez Bustamante, Raul Tonatiuh; Jirden, Lennart; Jones, Peter Graham; Jung, Hyung Taik; Jusko, Anton; Kakoyan, Vanik; Kalcher, Sebastian; Kalinak, Peter; Kalliokoski, Tuomo Esa Aukusti; Kalweit, Alexander Philipp; Kanaki, Kalliopi; Kang, Ju Hwan; Kaplin, Vladimir; Karasu Uysal, Ayben; Karavichev, Oleg; Karavicheva, Tatiana; Karpechev, Evgeny; Kazantsev, Andrey; Kebschull, Udo Wolfgang; Keidel, Ralf; Khan, Mohisin Mohammed; Khan, Palash; Khan, Shuaib Ahmad; Khanzadeev, Alexei; Kharlov, Yury; Kileng, Bjarte; Kim, Beomkyu; Kim, Dong Jo; Kim, Do Won; Kim, Jonghyun; Kim, Jin Sook; Kim, Minwoo; Kim, Mimae; Kim, Se Yong; Kim, Seon Hee; Kim, Taesoo; Kirsch, Stefan; Kisel, Ivan; Kiselev, Sergey; Kisiel, Adam Ryszard; Klay, Jennifer Lynn; Klein, Jochen; Klein-Bosing, Christian; Kluge, Alexander; Knichel, Michael Linus; Knospe, Anders Garritt; Koch, Kathrin; Kohler, Markus; Kolojvari, Anatoly; Kondratiev, Valery; Kondratyeva, Natalia; Konevskih, Artem; Korneev, Andrey; Kour, Ravjeet; Kowalski, Marek; Kox, Serge; Koyithatta Meethaleveedu, Greeshma; Kral, Jiri; Kralik, Ivan; Kramer, Frederick; Kraus, Ingrid Christine; Krawutschke, Tobias; Krelina, Michal; Kretz, Matthias; Krivda, Marian; Krizek, Filip; Krus, Miroslav; Kryshen, Evgeny; Krzewicki, Mikolaj; Kucheriaev, Yury; Kuhn, Christian Claude; Kuijer, Paul; Kulakov, Igor; Kumar, Jitendra; Kurashvili, Podist; Kurepin, A; Kurepin, AB; Kuryakin, Alexey; Kushpil, Svetlana; Kushpil, Vasily; Kweon, Min Jung; Kwon, Youngil; La Pointe, Sarah Louise; La Rocca, Paola; Ladron de Guevara, Pedro; Lakomov, Igor; Langoy, Rune; Lara, Camilo Ernesto; Lardeux, Antoine Xavier; Lazzeroni, Cristina; Le Bornec, Yves; Lea, Ramona; Lechman, Mateusz; Lee, Graham Richard; Lee, Ki Sang; Lee, Sung Chul; Lefevre, Frederic; Lehnert, Joerg Walter; Leistam, Lars; Lemmon, Roy Crawford; Lenhardt, Matthieu Laurent; Lenti, Vito; Leon Monzon, Ildefonso; Leon Vargas, Hermes; Leoncino, Marco; Levai, Peter; Lien, Jorgen; Lietava, Roman; Lindal, Svein; Lindenstruth, Volker; Lippmann, Christian; Lisa, Michael Annan; Liu, Lijiao; Loenne, Per-Ivar; Loggins, Vera; Loginov, Vitaly; Lohn, Stefan Bernhard; Lohner, Daniel; Loizides, Constantinos; Loo, Kai Krister; Lopez, Xavier Bernard; Lopez Torres, Ernesto; Lovhoiden, Gunnar; Lu, Xianguo; Luettig, Philipp; Lunardon, Marcello; Luo, Jiebin; Luparello, Grazia; Luquin, Lionel; Luzzi, Cinzia; Ma, Rongrong; Maevskaya, Alla; Mager, Magnus; Mahapatra, Durga Prasad; Maire, Antonin; Mal'Kevich, Dmitry; Malaev, Mikhail; Maldonado Cervantes, Ivonne Alicia; Malinina, Ludmila; Malzacher, Peter; Mamonov, Alexander; Manceau, Loic Henri Antoine; Manko, Vladislav; Manso, Franck; Manzari, Vito; Mao, Yaxian; Marchisone, Massimiliano; Mares, Jiri; Margagliotti, Giacomo Vito; Margotti, Anselmo; Marin, Ana Maria; Marin Tobon, Cesar Augusto; Markert, Christina; Martashvili, Irakli; Martinengo, Paolo; Martinez, Mario Ivan; Martinez Davalos, Arnulfo; Martinez Garcia, Gines; Martynov, Yevgen; Mas, Alexis Jean-Michel; Masciocchi, Silvia; Masera, Massimo; Masoni, Alberto; Mastromarco, Mario; Mastroserio, Annalisa; Matthews, Zoe Louise; Matyja, Adam Tomasz; Mayani, Daniel; Mayer, Christoph; Mazer, Joel; Mazzoni, Alessandra Maria; Meddi, Franco; Menchaca-Rocha, Arturo Alejandro; Mercado Perez, Jorge; Meres, Michal; Miake, Yasuo; Milano, Leonardo; Milosevic, Jovan; Mischke, Andre; Mishra, Aditya Nath; Miskowiec, Dariusz; Mitu, Ciprian Mihai; Mlynarz, Jocelyn; Mohanty, Ajit Kumar; Mohanty, Bedangadas; Molnar, Levente; Montano Zetina, Luis Manuel; Monteno, Marco; Montes, Esther; Moon, Taebong; Morando, Maurizio; Moreira De Godoy, Denise Aparecida; Moretto, Sandra; Morsch, Andreas; Muccifora, Valeria; Mudnic, Eugen; Muhuri, Sanjib; Mukherjee, Maitreyee; Muller, Hans; Munhoz, Marcelo; Musa, Luciano; Musso, Alfredo; Nandi, Basanta Kumar; Nania, Rosario; Nappi, Eugenio; Nattrass, Christine; Naumov, Nikolay; Navin, Sparsh; Nayak, Tapan Kumar; Nazarenko, Sergey; Nazarov, Gleb; Nedosekin, Alexander; Nicassio, Maria; Niculescu, Mihai; Nielsen, Borge Svane; Niida, Takafumi; Nikolaev, Sergey; Nikolic, Vedran; Nikulin, Sergey; Nikulin, Vladimir; Nilsen, Bjorn Steven; Nilsson, Mads Stormo; Noferini, Francesco; Nomokonov, Petr; Nooren, Gerardus; Novitzky, Norbert; Nyanin, Alexandre; Nyatha, Anitha; Nygaard, Casper; Nystrand, Joakim Ingemar; Oeschler, Helmut Oskar; Oh, Saehanseul; Oh, Sun Kun; Oleniacz, Janusz; Oppedisano, Chiara; Ortona, Giacomo; Oskarsson, Anders Nils Erik; Otwinowski, Jacek Tomasz; Oyama, Ken; Pachmayer, Yvonne Chiara; Pachr, Milos; Padilla, Fatima; Pagano, Paola; Paic, Guy; Painke, Florian; Pajares, Carlos; Pal, S; Pal, Susanta Kumar; Palaha, Arvinder Singh; Palmeri, Armando; Papikyan, Vardanush; Pappalardo, Giuseppe; Park, Woo Jin; Passfeld, Annika; Patalakha, Dmitri Ivanovich; Paticchio, Vincenzo; Pavlinov, Alexei; Pawlak, Tomasz Jan; Peitzmann, Thomas; Pereira Da Costa, Hugo Denis Antonio; Pereira De Oliveira Filho, Elienos; Peresunko, Dmitri; Perez Lara, Carlos Eugenio; Perez Lezama, Edgar; Perini, Diego; Perrino, Davide; Peryt, Wiktor Stanislaw; Pesci, Alessandro; Peskov, Vladimir; Pestov, Yury; Petracek, Vojtech; Petran, Michal; Petris, Mariana; Petrov, Plamen Rumenov; Petrovici, Mihai; Petta, Catia; Piano, Stefano; Piccotti, Anna; Pikna, Miroslav; Pillot, Philippe; Pinazza, Ombretta; Pinsky, Lawrence; Pitz, Nora; Piuz, Francois; Piyarathna, Danthasinghe; Ploskon, Mateusz Andrzej; Pluta, Jan Marian; Pochybova, Sona; Podesta Lerma, Pedro Luis Manuel; Poghosyan, Martin; Polichtchouk, Boris; Pop, Amalia; Porteboeuf-Houssais, Sarah; Pospisil, Vladimir; Potukuchi, Baba; Prasad, Sidharth Kumar; Preghenella, Roberto; Prino, Francesco; Pruneau, Claude Andre; Pshenichnov, Igor; Puchagin, Sergey; Puddu, Giovanna; Pujahari, Prabhat Ranjan; Pujol Teixido, Jordi; Pulvirenti, Alberto; Punin, Valery; Putis, Marian; Putschke, Jorn Henning; Quercigh, Emanuele; Qvigstad, Henrik; Rachevski, Alexandre; Rademakers, Alphonse; Radomski, Sylwester; Raiha, Tomi Samuli; Rak, Jan; Rakotozafindrabe, Andry Malala; Ramello, Luciano; Ramirez Reyes, Abdiel; Raniwala, Rashmi; Raniwala, Sudhir; Rasanen, Sami Sakari; Rascanu, Bogdan Theodor; Rathee, Deepika; Read, Kenneth Francis; Real, Jean-Sebastien; Redlich, Krzysztof; Reichelt, Patrick; Reicher, Martijn; Renfordt, Rainer Arno Ernst; Reolon, Anna Rita; Reshetin, Andrey; Rettig, Felix Vincenz; Revol, Jean-Pierre; Reygers, Klaus Johannes; Riccati, Lodovico; Ricci, Renato Angelo; Richert, Tuva; Richter, Matthias Rudolph; Riedler, Petra; Riegler, Werner; Riggi, Francesco; Rodrigues Fernandes Rabacal, Bartolomeu; Rodriguez Cahuantzi, Mario; Rodriguez Manso, Alis; Roed, Ketil; Rohr, David; Rohrich, Dieter; Romita, Rosa; Ronchetti, Federico; Rosnet, Philippe; Rossegger, Stefan; Rossi, Andrea; Roy, Christelle Sophie; Roy, Pradip Kumar; Rubio Montero, Antonio Juan; Rui, Rinaldo; Russo, Riccardo; Ryabinkin, Evgeny; Rybicki, Andrzej; Sadovsky, Sergey; Safarik, Karel; Sahoo, Raghunath; Sahu, Pradip Kumar; Saini, Jogender; Sakaguchi, Hiroaki; Sakai, Shingo; Sakata, Dosatsu; Salgado, Carlos Albert; Salzwedel, Jai; Sambyal, Sanjeev Singh; Samsonov, Vladimir; Sanchez Castro, Xitzel; Sandor, Ladislav; Sandoval, Andres; Sano, Masato; Sano, Satoshi; Santo, Rainer; Santoro, Romualdo; Sarkamo, Juho Jaako; Scapparone, Eugenio; Scarlassara, Fernando; Scharenberg, Rolf Paul; Schiaua, Claudiu Cornel; Schicker, Rainer Martin; Schmidt, Christian Joachim; Schmidt, Hans Rudolf; Schreiner, Steffen; Schuchmann, Simone; Schukraft, Jurgen; Schutz, Yves Roland; Schwarz, Kilian Eberhard; Schweda, Kai Oliver; Scioli, Gilda; Scomparin, Enrico; Scott, Patrick Aaron; Scott, Rebecca; Segato, Gianfranco; Selyuzhenkov, Ilya; Senyukov, Serhiy; Seo, Jeewon; Serci, Sergio; Serradilla, Eulogio; Sevcenco, Adrian; Shabetai, Alexandre; Shabratova, Galina; Shahoyan, Ruben; Sharma, Natasha; Sharma, Satish; Shigaki, Kenta; Shimomura, Maya; Shtejer, Katherin; Sibiriak, Yury; Siciliano, Melinda; Sicking, Eva; Siddhanta, Sabyasachi; Siemiarczuk, Teodor; Silvermyr, David Olle Rickard; Silvestre, Catherine; Simatovic, Goran; Simonetti, Giuseppe; Singaraju, Rama Narayana; Singh, Ranbir; Singha, Subhash; Singhal, Vikas; Sinha, Bikash; Sinha, Tinku; Sitar, Branislav; Sitta, Mario; Skaali, Bernhard; Skjerdal, Kyrre; Smakal, Radek; Smirnov, Nikolai; Snellings, Raimond; Sogaard, Carsten; Soltz, Ron Ariel; Son, Hyungsuk; Song, Jihye; Song, Myunggeun; Soos, Csaba; Soramel, Francesca; Sputowska, Iwona; Spyropoulou-Stassinaki, Martha; Srivastava, Brijesh Kumar; Stachel, Johanna; Stan, Ionel; Stefanek, Grzegorz; Stefanini, Giorgio; Steinbeck, Timm Morten; Steinpreis, Matthew; Stenlund, Evert Anders; Steyn, Gideon Francois; Stiller, Johannes Hendrik; Stocco, Diego; Stolpovskiy, Mikhail; Strabykin, Kirill; Strmen, Peter; Suaide, Alexandre Alarcon do Passo; Subieta Vasquez, Martin Alfonso; Sugitate, Toru; Suire, Christophe Pierre; Sukhorukov, Mikhail; Sultanov, Rishat; Sumbera, Michal; Susa, Tatjana; Szanto de Toledo, Alejandro; Szarka, Imrich; Szczepankiewicz, Adam; Szostak, Artur Krzysztof; Szymanski, Maciej; Takahashi, Jun; Tapia Takaki, Daniel Jesus; Tarazona Martinez, Alfonso; Tauro, Arturo; Tejeda Munoz, Guillermo; Telesca, Adriana; Terrevoli, Cristina; Thader, Jochen Mathias; Thomas, Deepa; Tieulent, Raphael Noel; Timmins, Anthony; Toia, Alberica; Torii, Hisayuki; Tosello, Flavio; Trzaska, Wladyslaw Henryk; Tsuji, Tomoya; Tumkin, Alexandr; Turrisi, Rosario; Tveter, Trine Spedstad; Ulery, Jason Glyndwr; Ullaland, Kjetil; Ulrich, Jochen; Uras, Antonio; Urban, Jozef; Urciuoli, Guido Marie; Usai, Gianluca; Vajzer, Michal; Vala, Martin; Valencia Palomo, Lizardo; Vallero, Sara; van der Kolk, Naomi; van Leeuwen, Marco; Vande Vyvre, Pierre; Vannucci, Luigi; Vargas, Aurora Diozcora; Varma, Raghava; Vasileiou, Maria; Vasiliev, Andrey; Vechernin, Vladimir; Veldhoen, Misha; Venaruzzo, Massimo; Vercellin, Ermanno; Vergara, Sergio; Vernet, Renaud; Verweij, Marta; Vickovic, Linda; Viesti, Giuseppe; Vikhlyantsev, Oleg; Vilakazi, Zabulon; Villalobos Baillie, Orlando; Vinogradov, Alexander; Vinogradov, Leonid; Vinogradov, Yury; Virgili, Tiziano; Viyogi, Yogendra; Vodopianov, Alexander; Voloshin, Kirill; Voloshin, Sergey; Volpe, Giacomo; von Haller, Barthelemy; Vranic, Danilo; Øvrebekk, Gaute; Vrlakova, Janka; Vulpescu, Bogdan; Vyushin, Alexey; Wagner, Boris; Wagner, Vladimir; Wan, Renzhuo; Wang, Dong; Wang, Mengliang; Wang, Yifei; Wang, Yaping; Watanabe, Kengo; Weber, Michael; Wessels, Johannes; Westerhoff, Uwe; Wiechula, Jens; Wikne, Jon; Wilde, Martin Rudolf; Wilk, Alexander; Wilk, Grzegorz Andrzej; Williams, Crispin; Windelband, Bernd Stefan; Xaplanteris Karampatsos, Leonidas; Yaldo, Chris G; Yamaguchi, Yorito; Yang, Hongyan; Yang, Shiming; Yasnopolsky, Stanislav; Yi, JunGyu; Yin, Zhongbao; Yoo, In-Kwon; Yoon, Jongik; Yu, Weilin; Yuan, Xianbao; Yushmanov, Igor; Zach, Cenek; Zampolli, Chiara; Zaporozhets, Sergey; Zarochentsev, Andrey; Zavada, Petr; Zaviyalov, Nikolai; Zbroszczyk, Hanna Paulina; Zelnicek, Pierre; Zgura, Sorin Ion; Zhalov, Mikhail; Zhang, Haitao; Zhang, Xiaoming; Zhou, Daicui; Zhou, Fengchu; Zhou, You; Zhu, Jianhui; Zhu, Xiangrong; Zichichi, Antonino; Zimmermann, Alice; Zinovjev, Gennady; Zoccarato, Yannick Denis; Zynovyev, Mykhaylo; Zyzak, Maksym

    2013-07-16

    Identical neutral kaon pair correlations are measured in $\\sqrt{s}$=7 TeV pp collisions in the ALICE experiment. One-dimensional K$^{0}_{s}$-K$^{0}_{s}$ correlation functions in terms of the invariant momentum difference of kaon pairs are formed in two multiplicity and two transverse momentum ranges. The femtoscopic parameters for the radius and correlation strength of the kaon source are extracted. The fit includes quantum statistics and final-state interactions of the $a_0/f_0$ resonance. K$^{0}_{s}$-K$^{0}_{s}$ correlations show an increase in radius for increasing multiplicity and a slight decrease in radius for increasing transverse mass, $m_T$, as seen in pion-pion correlations in the pp system and in heavy-ion collisions. Transverse mass scaling is observed between the K$^{0}_{s}$-K$^{0}_{s}$ and pion-pion radii. Also, the first observation is made of the decay of the $f_{2}'$(1525) meson into the K$^{0}_{s}$-K$^{0}_{s}$ channel in pp collisions.

  7. CORRELATIONS OF THE ARRIVAL DIRECTIONS OF ULTRA-HIGH ENERGY COSMIC RAYS WITH EXTRAGALACTIC OBJECTS AS OBSERVED BY THE TELESCOPE ARRAY EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    Abu-Zayyad, T.; Allen, M.; Anderson, R.; Barcikowski, E.; Belz, J. W.; Bergman, D. R.; Blake, S. A.; Cady, R.; Hanlon, W. [High Energy Astrophysics Institute and Department of Physics and Astronomy, University of Utah, Salt Lake City, UT (United States); Aida, R. [Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Kofu, Yamanashi (Japan); Azuma, R.; Fukuda, T. [Graduate School of Science and Engineering, Tokyo Institute of Technology, Meguro, Tokyo (Japan); Cheon, B. G.; Cho, E. J. [Department of Physics and The Research Institute of Natural Science, Hanyang University, Seongdong-gu, Seoul (Korea, Republic of); Chiba, J. [Department of Physics, Tokyo University of Science, Noda, Chiba (Japan); Chikawa, M. [Department of Physics, Kinki University, Higashi Osaka, Osaka (Japan); Cho, W. R. [Department of Physics, Yonsei University, Seodaemun-gu, Seoul (Korea, Republic of); Fujii, H. [Institute of Particle and Nuclear Studies, KEK, Tsukuba, Ibaraki (Japan); Fujii, T. [Graduate School of Science, Osaka City University, Osaka (Japan); Fukushima, M. [Institute for Cosmic Ray Research, University of Tokyo, Kashiwa, Chiba (Japan); and others

    2013-11-10

    We search for correlations between the positions of extragalactic objects and the arrival directions of ultra-high energy cosmic rays (UHECRs) with primary energy E ≥ 40 EeV as observed by the surface detector array of the Telescope Array (TA) experiment during the first 40 months of operation. We examine several public astronomical object catalogs, including the Veron-Cetty and Veron catalog of active galactic nuclei. We count the number of TA events correlated with objects in each catalog as a function of three parameters: the maximum angular separation between a TA event and an object, the minimum energy of the events, and the maximum redshift of the objects. We determine the combination of these parameters that maximizes the correlations, and we calculate the probability of having the same levels of correlations from an isotropic distribution of UHECR arrival directions. No statistically significant correlations are found when penalties for scanning over the above parameters and for searching in several catalogs are taken into account.

  8. Lung scintigraphy with nonspecific human immunoglobulin G (99mTc-HIG) in the evaluation of pulmonary involvement in connective tissue diseases: correlation with pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT)

    International Nuclear Information System (INIS)

    Kostopoulos, C.; Toubanakis, C.; Mamoulakis, C.; Gialafos, E.; Mavrikakis, M.; Koutsikos, J.; Zerva, C.; Leondi, A.; Moulopoulos, L.A.; Sfikakis, P.P.

    2008-01-01

    In patients with connective tissue diseases (CTD), the early detection and evaluation of the severity of the pulmonary involvement is mandatory. High-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) are considered to be valuable noninvasive diagnostic modalities. Radiopharmaceuticals have also been used for this purpose. Our aim was the evaluation of technetium-labeled human polyclonal immunoglobulin G (HIG) lung scintigraphy in the early detection and assessment of the severity of the pulmonary involvement in CTD patients. Fifty-two nonsmoking CTD patients were studied by PFTs, HRCT, and HIG. According to PFTs, patients were divided in group A (impaired PFTs - abnormal pulmonary function) and group B (normal pulmonary function). Semiquantitative analysis was done on HIG and HRCT and corresponding scores were obtained. Significant difference was found between HIG scores in the two groups (0.6 ± 0.07 vs 0.51 ± 0.08, P < 0.001). There was a statistically significant negative correlation between HIG scores and PFTs results and a positive correlation between HIG and HRCT scores. HIG demonstrated similar clinical performance to HRCT. At the best cut-off levels of their score (0.56 and 7, respectively), HIG had a superior sensitivity (77.5 vs 57.5%) with lower specificity (75 vs 91.7%). The combination of the two methods increased the sensitivity of abnormal findings at the expense of specificity. HIG scintigraphy can be used in the early detection and evaluation of the severity of the pulmonary involvement in CTD, whereas, when used in combination with HRCT, the detection of affected patients can be further improved. (orig.)

  9. Molecular Correlates of Cortical Network Modulation by Long-Term Sensory Experience in the Adult Rat Barrel Cortex

    Science.gov (United States)

    Vallès, Astrid; Granic, Ivica; De Weerd, Peter; Martens, Gerard J. M.

    2014-01-01

    Modulation of cortical network connectivity is crucial for an adaptive response to experience. In the rat barrel cortex, long-term sensory stimulation induces cortical network modifications and neuronal response changes of which the molecular basis is unknown. Here, we show that long-term somatosensory stimulation by enriched environment…

  10. SAS Code for Calculating Intraclass Correlation Coefficients and Effect Size Benchmarks for Site-Randomized Education Experiments

    Science.gov (United States)

    Brandon, Paul R.; Harrison, George M.; Lawton, Brian E.

    2013-01-01

    When evaluators plan site-randomized experiments, they must conduct the appropriate statistical power analyses. These analyses are most likely to be valid when they are based on data from the jurisdictions in which the studies are to be conducted. In this method note, we provide software code, in the form of a SAS macro, for producing statistical…

  11. The mathematical modeling of the experiment on the determination of correlation coefficients in neutron beta-decay

    Science.gov (United States)

    Serebrov, A. P.; Zherebtsov, O. M.; Klyushnikov, G. N.

    2018-05-01

    An experiment on the measurement of the ratio of the axial coupling constant to the vector one is under development. The main idea of the experiment is to measure the values of A and B in the same setup. An additional measurement of the polarization is not necessary. The accuracy achieved to date in measuring λ is 2 × 10-3. It is expected that in the experiment the accuracy will be of the order of 10-4. Some particular problems of mathematical modeling concerning the experiment on the measurement of the ratio of the axial coupling constant to the vector one are considered. The force lines for the given tabular field of a magnetic trap are studied. The dependences of the longitudinal and transverse field non-uniformity coefficients on the coordinates are regarded. A special computational algorithm based on the law of a charged particle motion along a local magnetic force line is performed for the calculation of the electrons and protons motion time as well as for the evaluation of the total number of electrons colliding with the detector surface. The average values of the cosines of the angles with the coefficients of a, A and B have been estimated.

  12. A scoping review of the experiences, benefits, and challenges involved in volunteer work among youth and young adults with a disability.

    Science.gov (United States)

    Lindsay, Sally

    2016-08-01

    To develop a better understanding of the experiences of volunteer work among youth with disabilities. A scoping review was undertaken to assess the benefits and challenges of volunteering among youth with disabilities. Comprehensive searches using six international databases were conducted. Eligible articles included: (a) youth aged 30 or younger, with a disability; (b) empirical research on the benefits or challenges of volunteering; (c) published in a peer-reviewed journal between 1980 and 2014. Of the 1558 articles identified, 20 articles - involving 1409 participants, aged 12-30, across five countries - met the inclusion criteria. Studies linked volunteering to the development of human capital (i.e. practical experience, improved self-determination, self-confidence, coping), enhanced social capital (i.e. social and communication skills, social inclusion) and improved cultural capital (i.e. helping others, contributing to community). Many youth with disabilities also encountered challenges - including lack of accessible volunteer opportunities, difficulties arranging transportation, and negative attitudes from potential supervisors. Young people with disabilities are willing and able to volunteer, and they report benefits of volunteering; however, they face many challenges in finding suitable volunteer positions. More rigorous research is needed to understand the health and social benefits of volunteering and how it can help youth develop career pathways. Implications for Rehabilitation Clinicians, educators and parents should discuss the benefits of volunteering with youth with disabilities and assist them in finding placements that match their interests and abilities. Managers and clinicians should consider incorporating volunteering into vocational rehabilitation programming (i.e. addressing how to find placements and connecting youth to organisations). Clinicians should encourage youth to take part in social and extracurricular activities to help build their

  13. Contribution of student involvement in production/service unit and experience of industry practices to entrepreneurial attitude and the impact entrepeneurship readiness of vocational high school students of great Malang

    Science.gov (United States)

    Mukminna, Halimahtus; Isnandar, Muladi

    2017-09-01

    Purpose of this research was to determine the contribution of student involvement in production/ service unit (X1), experience of industry practices (X2), and entrepreneurial attitude (Y) towards readiness entrepreneurship (Z) of vocational student regional Malang. The design of the study using a quantitative approach. The samples used as many as 130 respondents. Instruments used for collecting data in the form of questionnaires. Data analysis included descriptive and test of hypothesis. The result showed: that the description of data on the level of student involvement in production/ service unit, experience of industry practices, entrepreneurial attitude and entrepreneurship readiness in the high category. The contribution student involvement in production/ service unit of entrepreneurial attitude of 10.6%. The contribution experience of industry practices of entrepreneurial attitude of 17.4%. The contribution student involvement in production/ service unit and experience of industry practices simultaneously to entrepreneurial attitude of 44.1%. The contribution student involvement in production/ service unit of readiness entrepreneurship of 4%. The contribution experience of industry practices of readiness entrepreneurship of 5%. The contribution entrepreneurial attitude of readiness entrepreneurship of 16%. Finally, the contribution student involvement in production/ service unit, experience of industry practices, and entrepreneurial attitude simultaneously to readiness entrepreneurship of 50.3%.

  14. Measurement of transvers spin effects by means of two-hadron correlations in the COMPASS experiment; Messung transversaler Spineffekte mittels zwei Hadronen Korrelation am COMPASS-Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Massmann, Frank Michael

    2008-06-23

    The quark structure of the nucleon can at neglection of intrinsic quark transverse momenta be completely described by two quark distribution functions. These are the unpolarized quark distribution function q(x), the helicity distribution function {delta}q(x), and the transvers quark-spin distribution function {delta}{sub T}q(x). This lastly mentioned function called transversity function, is chirallyn odd an can therefore only be measured in a combination with another chirally odd function. An access possibility to the transversity function {delta}{sub T}q(x) is the semi-inclusive two-hadron production in deep inelastic scattering on a transversely polarized target. Thereby the folding of the chirally odd two-hadron interference fragmentation function (IFF) H{sub 1} {sup angle} (z,M{sub h}{sup 2}) and the chirally odd transversity function. The IFF H{sub 1} {sup angle} (z,M{sub h}{sup 2}) is the spin-dependent part of a fragmentation function, which describes the fragmentation of a transversely polarized quark in two unpolarized hadrons. The production of the two hadrons pursues in an interference between different wave-state of the hadron pairs. Azimuthal asymmetries in the produced hadron pairs are measured. The measurements, which are described in this thesis, were performed in the COMPASS experiment at CERN in the years 2002-2004, which is a solid-state-target experiment at the SPS accelerator. After an introduction in chapter 2 the basing theoretical concepts for the measurement of the transversity function are presented. In chapter 3 the COMPASS experiment is described. Finally in chapter 4 the evaluation methods are discussed, the results of the azimuthal asymmetries shown and compared with theoretical predictions. [German] Die Quark-Struktur des Nukleons laesst sich bei Vernachlaessigung intrinsischer Quarktransversalimpulse vollstaendig durch drei Quark Verteilungsfunktionen beschreiben. Diese sind die unpolarisierte Quark Verteilungsfunktion q(x), die

  15. Implementation of a complex multi-phase equation of state for cerium and its correlation with experiment

    Energy Technology Data Exchange (ETDEWEB)

    Cherne, Frank J [Los Alamos National Laboratory; Jensen, Brian J [Los Alamos National Laboratory; Elkin, Vyacheslav M [VNIITF

    2009-01-01

    The complexity of cerium combined with its interesting material properties makes it a desirable material to examine dynamically. Characteristics such as the softening of the material before the phase change, low pressure solid-solid phase change, predicted low pressure melt boundary, and the solid-solid critical point add complexity to the construction of its equation of state. Currently, we are incorporating a feedback loop between a theoretical understanding of the material and an experimental understanding. Using a model equation of state for cerium we compare calculated wave profiles with experimental wave profiles for a number of front surface impact (cerium impacting a plated window) experiments. Using the calculated release isentrope we predict the temperature of the observed rarefaction shock. These experiments showed that the release state occurs at different magnitudes, thus allowing us to infer where dynamic {gamma} - {alpha} phase boundary is.

  16. Setting up the photoluminescence laboratory at ISOLDE & Perturbed Angular Correlation spectroscopy for BIO physics experiments using radioactive ions

    CERN Document Server

    Savva, Giannis

    2016-01-01

    The proposed project I was assigned was to set up the photoluminescence (PL) laboratory at ISOLDE, under the supervision of Karl Johnston. My first week at CERN coincided with the run of a BIO physics experiment using radioactive Hg(II) ions in which I also participated under the supervision of Stavroula Pallada. This gave me the opportunity to work in two projects during my stay at CERN and in the present report I describe briefly my contribution to them.

  17. A story of scrutiny and fear: Australian midwives' experiences of an external review of obstetric services, being involved with litigation and the impact on clinical practice.

    Science.gov (United States)

    Hood, Laraine; Fenwick, Jennifer; Butt, Janice

    2010-06-01

    to describe Australian midwives' experiences of an external review of obstetric services, involvement in legal proceedings and the impact on midwives' clinical practice and personal wellbeing. the external review process (commonly referred to as the 'Douglas Inquiry') was initiated by a state government and was in response to hospital staff and consumer complaints that focused on anomalies in client care and a significantly high rate of adverse outcomes and clinical errors. It took place within the context of a number of legal proceedings against medical practitioners. As a result, some midwives employed by the hospital were called to give evidence at a variety of legal forums. a qualitative study using an explorative descriptive design. Snowball sampling was used to invite 16 Australian midwives to participate in a tape-recorded interview. Thematic analysis and the techniques associated with constant comparison were used to analyse the data. Australian maternity tertiary referral centre. the analysis identified two overarching themes, 'A story of scrutiny' and 'A story of fear', each with a number of subthemes. 'A story of scrutiny' consists of three subthemes. 'A cloak and dagger affair' reflects the midwives' sense of being and feeling 'exposed' and 'vulnerable' whilst simultaneously being 'kept in the dark' and uninformed during the review process. The subtheme 'Being thrown to the wolves' describes the midwives' experiences of being involved, as witnesses, in medico-legal proceedings. The third subtheme, 'The Inquiry followed them home' outlines the effect on midwives' emotional wellbeing and personal relationships. The second major theme, 'A story of fear' again consists of a number of subthemes. 'Feeling unsafe at work: a culture of fear' describes the midwives' experiences of working within an environment they perceive as driven by the fear of litigation. In order to protect themselves and maintain a sense of control, the midwives adopted a number of

  18. The role of self-coherence in correlations of bosons and fermions in linear counting experiments. Notes on the wave-particle duality

    International Nuclear Information System (INIS)

    Varro, S.

    2011-01-01

    Correlations of detection events in two detectors are studied in case of linear excitations of the measuring apparatus. On the basis of classical probability theory and fundamental conservation laws, a general formula is derived for the two-point correlation functions for both bosons and fermions. The results obtained coincide with that derivable from quantum theory which uses quantized field amplitudes. By applying both the particle and the wave picture at the same time, the phenomena of photon bunching and antibunching, photon anticorrelation and fermion antibunching measured in beam experiments are interpreted in the frame of an intuitively clear description. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  19. Effect of genomic long-range correlations on DNA persistence length: from theory to single molecule experiments.

    Science.gov (United States)

    Moukhtar, Julien; Faivre-Moskalenko, Cendrine; Milani, Pascale; Audit, Benjamin; Vaillant, Cedric; Fontaine, Emeline; Mongelard, Fabien; Lavorel, Guillaume; St-Jean, Philippe; Bouvet, Philippe; Argoul, Françoise; Arneodo, Alain

    2010-04-22

    Sequence dependency of DNA intrinsic bending properties has been emphasized as a possible key ingredient to in vivo chromatin organization. We use atomic force microscopy (AFM) in air and liquid to image intrinsically straight (synthetic), uncorrelated (hepatitis C RNA virus) and persistent long-range correlated (human) DNA fragments in various ionic conditions such that the molecules freely equilibrate on the mica surface before being captured in a particular conformation. 2D thermodynamic equilibrium is experimentally verified by a detailed statistical analysis of the Gaussian nature of the DNA bend angle fluctuations. We show that the worm-like chain (WLC) model, commonly used to describe the average conformation of long semiflexible polymers, reproduces remarkably well the persistence length estimates for the first two molecules as consistently obtained from (i) mean square end-to-end distance measurement and (ii) mean projection of the end-to-end vector on the initial orientation. Whatever the operating conditions (air or liquid, concentration of metal cations Mg(2+) and/or Ni(2+)), the persistence length found for the uncorrelated viral DNA underestimates the value obtained for the straight DNA. We show that this systematic difference is the signature of the presence of an uncorrelated structural intrinsic disorder in the hepatitis C virus (HCV) DNA fragment that superimposes on local curvatures induced by thermal fluctuations and that only the entropic disorder depends upon experimental conditions. In contrast, the WLC model fails to describe the human DNA conformations. We use a mean-field extension of the WLC model to account for the presence of long-range correlations (LRC) in the intrinsic curvature disorder of human genomic DNA: the stronger the LRC, the smaller the persistence length. The comparison of AFM imaging of human DNA with LRC DNA simulations confirms that the rather small mean square end-to-end distance observed, particularly for G

  20. Categorization for Faces and Tools-Two Classes of Objects Shaped by Different Experience-Differs in Processing Timing, Brain Areas Involved, and Repetition Effects.

    Science.gov (United States)

    Kozunov, Vladimir; Nikolaeva, Anastasia; Stroganova, Tatiana A

    2017-01-01

    The brain mechanisms that integrate the separate features of sensory input into a meaningful percept depend upon the prior experience of interaction with the object and differ between categories of objects. Recent studies using representational similarity analysis (RSA) have characterized either the spatial patterns of brain activity for different categories of objects or described how category structure in neuronal representations emerges in time, but never simultaneously. Here we applied a novel, region-based, multivariate pattern classification approach in combination with RSA to magnetoencephalography data to extract activity associated with qualitatively distinct processing stages of visual perception. We asked participants to name what they see whilst viewing bitonal visual stimuli of two categories predominantly shaped by either value-dependent or sensorimotor experience, namely faces and tools, and meaningless images. We aimed to disambiguate the spatiotemporal patterns of brain activity between the meaningful categories and determine which differences in their processing were attributable to either perceptual categorization per se , or later-stage mentalizing-related processes. We have extracted three stages of cortical activity corresponding to low-level processing, category-specific feature binding, and supra-categorical processing. All face-specific spatiotemporal patterns were associated with bilateral activation of ventral occipito-temporal areas during the feature binding stage at 140-170 ms. The tool-specific activity was found both within the categorization stage and in a later period not thought to be associated with binding processes. The tool-specific binding-related activity was detected within a 210-220 ms window and was located to the intraparietal sulcus of the left hemisphere. Brain activity common for both meaningful categories started at 250 ms and included widely distributed assemblies within parietal, temporal, and prefrontal regions

  1. Improving the counting efficiency in time-correlated single photon counting experiments by dead-time optimization

    Energy Technology Data Exchange (ETDEWEB)

    Peronio, P.; Acconcia, G.; Rech, I.; Ghioni, M. [Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2015-11-15

    Time-Correlated Single Photon Counting (TCSPC) has been long recognized as the most sensitive method for fluorescence lifetime measurements, but often requiring “long” data acquisition times. This drawback is related to the limited counting capability of the TCSPC technique, due to pile-up and counting loss effects. In recent years, multi-module TCSPC systems have been introduced to overcome this issue. Splitting the light into several detectors connected to independent TCSPC modules proportionally increases the counting capability. Of course, multi-module operation also increases the system cost and can cause space and power supply problems. In this paper, we propose an alternative approach based on a new detector and processing electronics designed to reduce the overall system dead time, thus enabling efficient photon collection at high excitation rate. We present a fast active quenching circuit for single-photon avalanche diodes which features a minimum dead time of 12.4 ns. We also introduce a new Time-to-Amplitude Converter (TAC) able to attain extra-short dead time thanks to the combination of a scalable array of monolithically integrated TACs and a sequential router. The fast TAC (F-TAC) makes it possible to operate the system towards the upper limit of detector count rate capability (∼80 Mcps) with reduced pile-up losses, addressing one of the historic criticisms of TCSPC. Preliminary measurements on the F-TAC are presented and discussed.

  2. Highly efficient router-based readout algorithm for single-photon-avalanche-diode imagers for time-correlated experiments

    Science.gov (United States)

    Cominelli, A.; Acconcia, G.; Caldi, F.; Peronio, P.; Ghioni, M.; Rech, I.

    2018-02-01

    Time-Correlated Single Photon Counting (TCSPC) is a powerful tool that permits to record extremely fast optical signals with a precision down to few picoseconds. On the other hand, it is recognized as a relatively slow technique, especially when a large time-resolved image is acquired exploiting a single acquisition channel and a scanning system. During the last years, much effort has been made towards the parallelization of many acquisition and conversion chains. In particular, the exploitation of Single-Photon Avalanche Diodes in standard CMOS technology has paved the way to the integration of thousands of independent channels on the same chip. Unfortunately, the presence of a large number of detectors can give rise to a huge rate of events, which can easily lead to the saturation of the transfer rate toward the elaboration unit. As a result, a smart readout approach is needed to guarantee an efficient exploitation of the limited transfer bandwidth. We recently introduced a novel readout architecture, aimed at maximizing the counting efficiency of the system in typical TCSPC measurements. It features a limited number of high-performance converters, which are shared with a much larger array, while a smart routing logic provides a dynamic multiplexing between the two parts. Here we propose a novel routing algorithm, which exploits standard digital gates distributed among a large 32x32 array to ensure a dynamic connection between detectors and external time-measurement circuits.

  3. An experiment to measure lambda=G sub A /G sub V from a combination of angular correlation coefficients in the beta decay of polarized neutrons

    CERN Document Server

    Kuznetsov, I A; Serebrov, A P; Solovei, V A; Stepanenko, I V; Vasilev, A V; Mostovoy, Y A; Zimmer, O; Yerozolimsky, B G; Dewey, M S; Wietfeldt, F E

    2000-01-01

    A technique is described which allows us to measure the ratio lambda=G sub A /G sub V of the weak axial-vector and vector coupling constants in neutron decay without any measurement of the neutron beam polarization. lambda is determined from a combination of the parity-odd angular correlations sigma-> centre dot p-> sub e and sigma-> centre dot p-> subnu between the neutron spin sigma-> and the electron momentum p-> sub e and the anti-neutrino momentum p-> subnu, respectively, both of which are measured in a single experiment using the same neutron beam. A description of the experiment and the results of the first run at the cold neutron beam facility at the Institut Laue-Langevin are presented.

  4. Reading in the dark: neural correlates and cross-modal plasticity for learning to read entire words without visual experience.

    Science.gov (United States)

    Sigalov, Nadine; Maidenbaum, Shachar; Amedi, Amir

    2016-03-01

    Cognitive neuroscience has long attempted to determine the ways in which cortical selectivity develops, and the impact of nature vs. nurture on it. Congenital blindness (CB) offers a unique opportunity to test this question as the brains of blind individuals develop without visual experience. Here we approach this question through the reading network. Several areas in the visual cortex have been implicated as part of the reading network, and one of the main ones among them is the VWFA, which is selective to the form of letters and words. But what happens in the CB brain? On the one hand, it has been shown that cross-modal plasticity leads to the recruitment of occipital areas, including the VWFA, for linguistic tasks. On the other hand, we have recently demonstrated VWFA activity for letters in contrast to other visual categories when the information is provided via other senses such as touch or audition. Which of these tasks is more dominant? By which mechanism does the CB brain process reading? Using fMRI and visual-to-auditory sensory substitution which transfers the topographical features of the letters we compare reading with semantic and scrambled conditions in a group of CB. We found activation in early auditory and visual cortices during the early processing phase (letter), while the later phase (word) showed VWFA and bilateral dorsal-intraparietal activations for words. This further supports the notion that many visual regions in general, even early visual areas, also maintain a predilection for task processing even when the modality is variable and in spite of putative lifelong linguistic cross-modal plasticity. Furthermore, we find that the VWFA is recruited preferentially for letter and word form, while it was not recruited, and even exhibited deactivation, for an immediately subsequent semantic task suggesting that despite only short sensory substitution experience orthographic task processing can dominate semantic processing in the VWFA. On a wider

  5. The Impact of Direct Involvement I and Direct Involvement II Experiences on Secondary School Students' Social Capital, as Measured by Co-Cognitive Factors of the Operation Houndstooth Intervention Theory

    Science.gov (United States)

    Sands, Michelle M.; Heilbronner, Nancy N.

    2014-01-01

    A mixed-methods study grounded in Renzulli's Operation Houndstooth Intervention Theory examined the impact of different types of volunteer experiences on the six co-cognitive factors (Optimism, Courage, Romance With a Topic/Discipline, Sensitivity to Human Concerns, Physical/Mental Energy, and Vision/Sense of Destiny) associated with the…

  6. Do serum BDNF levels vary in self-harm behavior among adolescents and are they correlated with traumatic experiences?

    Science.gov (United States)

    Kavurma, Canem; Varol Tas, Fatma; Serim Demirgoren, Burcu; Demirci, Ferhat; Akan, Pınar; Eyuboglu, Damla; Guvenir, Taner

    2017-12-01

    The aim of this study was to compare serum brain-derived neurotrophic factor (BDNF) levels between adolescents that harm themselves, those that receive psychiatric treatment but do not harm themselves, healthy adolescents, and childhood traumas and to investigate the relationship between traumatic experiences and serum BDNF levels. The cases were divided into two groups of 40 adolescents exhibiting self-harm behavior (self-harm/diagnosed group) and 30 adolescents receiving psychiatric treatment but not exhibiting self-harm behaviors (non self-harm/diagnosed group). The control group (healthy control group) consisted of 35 healthy adolescents with no psychiatric disorders or self-harm behaviors. The adolescents were asked to fill in the Inventory of Statements About Self Injury (ISAS) and Childhood Trauma Questionnaire (CTQ). For BDNF measurement, blood samples were taken from the cases and controls. The serum BDNF level of self-harming adolescents who used the self-cutting method was significantly lower than that of other groups, and serum BDNF levels decreased with the increase in the emotional neglect and abuse severity of self-harming adolescents during childhood. In our study, serum BDNF levels decreased with the increase in emotional abuse in self-harming adolescents. This finding may indicate that neuroplasticity can be affected by a negative emotional environment during the early period. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Foreground and Sensitivity Analysis for Broadband (2D) 21 cm-Lyα and 21 cm-Hα Correlation Experiments Probing the Epoch of Reionization

    Science.gov (United States)

    Neben, Abraham R.; Stalder, Brian; Hewitt, Jacqueline N.; Tonry, John L.

    2017-11-01

    A detection of the predicted anticorrelation between 21 cm and either Lyα or Hα from the epoch of reionization (EOR) would be a powerful probe of the first galaxies. While 3D intensity maps isolate foregrounds in low-{k}\\parallel modes, infrared surveys cannot yet match the field of view and redshift resolution of radio intensity mapping experiments. In contrast, 2D (I.e., broadband) infrared intensity maps can be measured with current experiments and are limited by foregrounds instead of photon or thermal noise. We show that 2D experiments can measure most of the 3D fluctuation power at klimit on residual foregrounds of the 21 cm-Lyα cross-power spectrum at z˜ 7 of {{{Δ }}}2text{kJy sr}}-1 {{mK}}) (95%) at {\\ell }˜ 800. We predict levels of foreground correlation and sample variance noise in future experiments, showing that higher-resolution surveys such as LOFAR, SKA-LOW, and the Dark Energy Survey can start to probe models of the 21 cm-Lyα EOR cross spectrum.

  8. Electronic structure and magnetic properties of Pr-Co intermetallics: ab initio FP-LAPW calculations and correlation with experiments

    Science.gov (United States)

    Bakkari, Karim; Fersi, Riadh; Kebir Hlil, El; Bessais, Lotfi; Thabet Mliki, Najeh

    2018-03-01

    First-principle calculations combining density functional theory and the full-potential linearized augmented plane wave (FP-LAPW) method are performed to investigate the electronic and magnetic structure of Pr2Co7 in its two polymorphic forms, (2:7 H) and (2:7 R), for the first time. This type of calculation was also performed for PrCo5 and PrCo2 intermetallics. We have computed the valence density of states separately for spin-up and spin-down states in order to investigate the electronic band structure. This is governed by the strong contribution of the partial DOS of 3d-Co bands compared to the partial DOS of the 4f-Pr bands. Such a high ferromagnetic state is discussed in terms of the strong spin polarization observed in the total DOS. The magnetic moments carried by the Co and Pr atoms located in several sites for all compounds are computed. These results mainly indicate that cobalt atoms make a dominant contribution to the magnetic moments. The notable difference in the atomic moments of Pr and Co atoms between different structural slabs is explained in terms of the magnetic characteristics of the PrCo2 and PrCo5 compounds and the local chemical environments of the Pr and Co atoms in different structural slabs of Pr2Co7. From spin-polarized calculations we have simulated the 3d and 4f band population to estimate the local magnetic moments. These results are in accordance with the magnetic moments calculated using the FP-LAPW method. In addition, the exchange interactions J ij are calculated and used as input for M(T) simulations. Involving the data obtained from the electronic structure calculations, the appropriate Padé Table is applied to simulate the magnetization M(T) and to estimate the mean-field Curie temperature. We report a fairly good agreement between the ab initio calculation of magnetization and Curie temperature with the experimental data.

  9. Correlation of MRI with arthroscopy for the evaluation of the subscapularis tendon: a musculoskeletal division's experience

    Energy Technology Data Exchange (ETDEWEB)

    Gyftopoulos, Soterios; O' Donnell, John; Shah, Neil Pravin; Goss, Jordan; Babb, James; Recht, Michael P. [NYU Langone Medical Center, Department of Radiology, New York, NY (United States)

    2013-09-15

    To determine the accuracy of MR imaging for the evaluation of the subscapularis tendon as well as define imaging findings that will increase accuracy. Retrospective review of the MR and operative (OR) reports of 286 patients was conducted and reviewed for the presence/degree (partial (PT)/full-thickness (FT)) of tearing; only PT articular tears were included. The presence of a supraspinatus tear and time interval between surgery and MRI were also documented. All of the PT tears called on MRI were also reviewed to see if there was a statistically significant association between certain imaging characteristics and the presence of a tear in surgery. Statistical analysis included 95 % confidence intervals, Fisher's exact, and exact Mann-Whitney tests. A total of 244 patients were included in the study with a total of 25 subscapularis tears, 16 PT and nine FT, and 219 intact tendons in arthroscopy; 20/25 tears and 200 intact tendons were diagnosed correctly on MRI, resulting in sensitivity of 80 %, specificity of 91 %, accuracy of 90 %, positive predictive value of 51 %, and negative predictive value of 98 %. There was a significant association between the presence of a PT tear during arthroscopy and fluid-like signal within the tendon on more than one imaging plane (p < 0.001) with an accuracy of 90 %. This study reflects a musculoskeletal radiology section's experience with the diagnosis of subscapularis tendon pathology, demonstrating that MRI could be used to accurately evaluate the subscapularis tendon. An understanding of certain imaging pitfalls and the presence of fluid-like signal on multiple imaging planes should increase the diagnostic accuracy of the radiologist evaluating the subscapularis tendon for the presence of a tear. (orig.)

  10. Parental involvement

    Directory of Open Access Journals (Sweden)

    Ezra S Simon

    2005-01-01

    Full Text Available Parent-Teacher Associations and other community groups can play a significant role in helping to establish and run refugee schools; their involvement can also help refugee adults adjust to their changed circumstances.

  11. Has Family Involvement Migrated into Higher Education? An Investigation of How Administrative Staff Document the Phenomenon in Students' University Experiences in Cyprus

    Science.gov (United States)

    Symeou, Loizos; Theodorou, Eleni; Lamprianou, Iasonas; Rentzou, Konstantina; Andreou, Panayiota

    2018-01-01

    Families have been getting more and more involved in their children's education. This paper presents findings of a study investigating family involvement in their members' undergraduate studies attending a state (non-fee-paying) and a private (fee-paying) university in Cyprus. The data presented in the paper were collected via online logs…

  12. Strange particle correlations measured by the Star experiment in ultra-relativistic heavy ion collisions a RHIC; Etude des correlations de particules etranges mesurees par l'experience STAR dans les collisions d'ions lourds ultra-relativistes au RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Renault, G

    2004-09-01

    Non-identical correlation functions allow to study the space-time evolution of the source of particles formed in ultra-relativistic heavy ion collisions. The STAR experiment is dedicated to probe the formation of a new state of nuclear matter called Quark Gluon Plasma. The proton - lambda correlation function is supposed to be more sensitive to bigger source sizes than the proton - proton because of the absence of the final state Coulomb interaction. In this thesis, proton - lambda, anti-proton - anti-lambda, anti-proton - lambda and proton - anti-lambda correlation functions are studied in Au+Au collisions at {radical}S{sub NN} = 200 GeV using an analytical model. The proton - lambda and anti-proton - anti-lambda correlation functions exhibit the same behavior as in previous measurements. The anti-proton - lambda and proton - anti-lambda correlation functions, measured for the first time, show a very strong signal corresponding to the baryon - anti-baryon annihilation channel. Parameterizing the correlation functions has allowed to characterize final state interactions. (author)

  13. Anesthesia preparation time is not affected by the experience level of the resident involved during his/her first month of adult cardiac surgery.

    Science.gov (United States)

    Broussard, David M; Couch, Michael C

    2011-10-01

    This study was designed to answer the question of whether the experience level of the resident on his/her first month of adult cardiothoracic anesthesiology has an impact on operating room efficiency in a large academic medical center. Traditionally, the resident's 1st month of cardiac anesthesia had been reserved for the clinical anesthesia (CA)-2 year of training. This study analyzed the impact on operating room efficiency of moving the 1st month of cardiac anesthesia into the CA-1 year. The authors hypothesized that there would be no difference in anesthesia preparation times (defined as the interval between "in-room" and "anesthesia-ready" times) between CA-1 and CA-2 residents on their 1st month of cardiac anesthesia. This study was retrospective and used an electronic anesthesia information management system database. This study was conducted on care provided at a single 450-bed academic medical center. This study included 12 residents in their 1st month of cardiac anesthesia. The anesthesia preparation time (defined as the interval between "in-room" and "anesthesia-ready" times) was measured for cases involving residents on their first month of cardiac anesthesia. Anesthesia preparation times for 6 CA-1 resident months and 6 CA-2 resident months (100 adult cardiac procedures in total) were analyzed (49 for the CA-1 residents and 51 for the CA-2s). There were no differences in preparation time between CA-1 and CA-2 residents as a group (p = 0.8169). The CA-1 residents had an unadjusted mean (±standard error) of 51.1 ± 3.18 minutes, whereas the CA-2 residents' unadjusted mean was 50.2 ± 2.41 minutes. Adjusting for case mix (valves v coronary artery bypass graft surgery), the CA-1 mean was 49.1 ± 5.22 minutes, whereas the CA-2 mean was 49.1 ± 4.54 minutes. These findings suggest that operating room efficiency as measured by the anesthesia preparation time may not be affected by the level of the resident on his/her 1st month of adult cardiac anesthesia

  14. [An intergenerational health promotion program involving older adults in urban areas. "Research of Productivity by Intergenerational Sympathy (REPRINTS)": first-year experience and short-term effects].

    Science.gov (United States)

    Fujiwara, Yoshinori; Nishi, Mariko; Watanabe, Naoki; Lee, Sangyoon; Inoue, Kazuko; Yoshida, Hiroto; Sakuma, Naoko; Kureta, Youichi; Ishii, Kenji; Uchida, Hayato; Kakuno, Fumihiko; Shinkai, Shoji

    2006-09-01

    We have launched a new intervention study, called "Research of Productivity by Intergenerational Sympathy (REPRINTS)" in which senior volunteers engage in reading picture books to children. The "REPRINTS" program consistently involves social roles and intellectual activity, two higher-level functional capacities. This study reported findings and problems experienced through "REPRINTS" during the first year, ascertained potential effectiveness of social activity, and proposed methods for continued activity. Basic concepts of "REPRINTS"program include "contribution to society", "life-long learning", and "group activity." Sixty seven volunteers and 74 controls, all aged 60 years and over living in three areas, ie., Chuo-ku, central Tokyo, Kawasaki city, suburb of Tokyo and Nagahama city, a local city, participated in a baseline health check-up in June, 2004. After completion of 3-month training seminars (once a week, 2 hr per session), volunteers visited public elementary schools and kindergartens in groups of 6-10 persons for 6 months. They were assessed again by follow-up health check-up in March, 2005. At baseline, the proportion of those who had no grand children (41.8% vs. 20.3%, P= 0.006), average school years (13.4 +/- 2.5 vs. 12.3 +/- 2.5 years, P= 0.008), having any experience of volunteer activities (79.1% vs. 52.7%, P=0.001), and an usual walking speed (86.7 +/- 12.3 vs. 81.3 +/- 12.9 m/min, P=0.012) were significantly higher in volunteers than in controls. There was no significant difference in other baseline characteristics between the two groups. At follow-up, social network scores for 56 volunteers were significantly improved: frequency of contact with grandchildren and others around neighborhood and size of circles of friends and acquaintances were increased, as compared to controls. Social support scores for the volunteers significantly decreased in the receiving aspect, while increased in the giving aspect. In addition, consciousness of loving

  15. The forgotten artist: Why to consider intentions and interaction in a model of aesthetic experience. Comment on "Move me, astonish me... delight my eyes and brain: The Vienna Integrated Model of top-down and bottom-up processes in Art Perception (VIMAP) and corresponding affective, evaluative, and neurophysiological correlates" by Matthew Pelowski et al.

    Science.gov (United States)

    Brattico, Elvira; Brattico, Pauli; Vuust, Peter

    2017-07-01

    In their target article published in this journal issue, Pelowski et al. [1] address the question of how humans experience, and respond to, visual art. They propose a multi-layered model of the representations and processes involved in assessing visual art objects that, furthermore, involves both bottom-up and top-down elements. Their model provides predictions for seven different outcomes of human aesthetic experience, based on few distinct features (schema congruence, self-relevance, and coping necessity), and connects the underlying processing stages to ;specific correlates of the brain; (a similar attempt was previously done for music by [2-4]). In doing this, the model aims to account for the (often profound) experience of an individual viewer in front of an art object.

  16. Practice Makes Perfect: Correlations Between Prior Experience in High-level Athletics and Robotic Surgical Performance Do Not Persist After Task Repetition.

    Science.gov (United States)

    Shee, Kevin; Ghali, Fady M; Hyams, Elias S

    Robotic surgical skill development is central to training in urology as well as in other surgical disciplines. Here, we describe a pilot study assessing the relationships between robotic surgery simulator performance and 3 categories of activities, namely, videogames, musical instruments, and athletics. A questionnaire was administered to preclinical medical students for general demographic information and prior experiences in surgery, videogames, musical instruments, and athletics. For follow-up performance studies, we used the Matchboard Level 1 and 2 modules on the da Vinci Skills Simulator, and recorded overall score, time to complete, economy of motion, workspace range, instrument collisions, instruments out of view, and drops. Task 1 was run once, whereas task 2 was run 3 times. All performance studies on the da Vinci Surgical Skills Simulator took place in the Simulation Center at Dartmouth-Hitchcock Medical Center. All participants were medical students at the Geisel School of Medicine. After excluding students with prior hands-on experience in surgery, a total of 30 students completed the study. We found a significant correlation between athletic skill level and performance for both task 1 (p = 0.0002) and task 2 (p = 0.0009). No significant correlations were found for videogame or musical instrument skill level. Students with experience in certain athletics (e.g., volleyball, tennis, and baseball) tended to perform better than students with experience in other athletics (e.g., track and field). For task 2, which was run 3 times, this association did not persist after the third repetition due to significant improvements in students with low-level athletic skill (levels 0-2). Our study suggests that prior experience in high-level athletics, but not videogames or musical instruments, significantly influences surgical proficiency in robot-naive students. Furthermore, our study suggests that practice through task repetition can overcome initial differences

  17. Multiplicity dependence of two-particle correlation in $\\sqrt{s}$ = 7 TeV pp collisions at LHC-ALICE experiment

    CERN Document Server

    Bhom, Jihyun; Esumi, Shinlchi

    Early stage of universe or inside of neutron stars are supposed to be Quark Gluon Plasma (QGP) state. The QGP is a state of matter in quantum chromodynamics (QCD), which exists at extremely high temperature and/or high density. In high energy nuclear collisions experiment, hot dense matter or QGP has been studied, the collective flow of the system has been one of key issues to understand the state of matter. Large Hadron Collider (LHC) has served pp collisions at a nucleon–nucleon center-of-mass energy of 7 TeV in 2010, where the maximum charged particle multiplicity has been measured as large as 100$\\sim$200 charged particles in $|\\eta|<$2.5 in $dN/d\\eta$ like Cu-Cu collisions $\\sqrt {s_{NN}} = 200$ GeV at mid-peripheral at RHIC. A Large Ion Collider Experiment (ALICE) detector at the LHC is optimized for studying the high-temperature and high-density system called as QGP. Angular correlations between two charged particles are measured with central and forward detectors in ALICE experiment. Th...

  18. Experiments and Simulations of the Use of Time-Correlated Thermal Neutron Counting to Determine the Multiplication of an Assembly of Highly Enriched Uranium

    Energy Technology Data Exchange (ETDEWEB)

    David L. Chichester; Mathew T. Kinlaw; Scott M. Watson; Jeffrey M. Kalter; Eric C. Miller; William A. Noonan

    2014-11-01

    A series of experiments and numerical simulations using thermal-neutron time-correlated measurements has been performed to determine the neutron multiplication, M, of assemblies of highly enriched uranium available at Idaho National Laboratory. The experiments used up to 14.4 kg of highly-enriched uranium, including bare assemblies and assemblies reflected with high-density polyethylene, carbon steel, and tungsten. A small 252Cf source was used to initiate fission chains within the assembly. Both the experiments and the simulations used 6-channel and 8-channel detector systems, each consisting of 3He proportional counters moderated with polyethylene; data was recorded in list mode for analysis. 'True' multiplication values for each assembly were empirically derived using basic neutron production and loss values determined through simulation. A total of one-hundred and sixteen separate measurements were performed using fifty-seven unique measurement scenarios, the multiplication varied from 1.75 to 10.90. This paper presents the results of these comparisons and discusses differences among the various cases.

  19. Correlation of Dental Caries Experience with pH, Buffering Capacity and Flow Rate of Saliva among 15-year-old School Children in Mangalore

    Directory of Open Access Journals (Sweden)

    Vijay S Kumar

    2013-01-01

    Full Text Available Aim and Objectives: To correlate dental caries experience with pH, buffering capacity and flow rate of saliva among 15-year-old-children Materials & Method : Fifteen year old school children from adopted schools of a dental college in Mangalore were considered as study subjects. The study was carried out using a standardized proforma that consisted of questionnaire for recording demographic data. The caries experience was assessed by DMFT Index. Salivary pH was measured by using a pH meter and salivary buffering capacity was measured by using titration method. Unstimulated whole saliva was collected from all subjects by direct expectoration to calculate the flow rate. Results: The mean DMFT of the study population was 2.85 ± 2.5. The mean salivary pH was found to be 6.88 ± 0.69.About 74.1% were having medium salivary buffering capacities. The mean unstimulated salivary flow rate and mean total antioxidant capacity of the study population was 0.41 ± 0.14 ml/min and 94.15 ± 60.72 g/dL respectively. Conclusions: A marked association between the pH, buffering capacity and unstimulated flow rate with dental caries experience suggest that assessment of these salivary parameters can be used as predictors for future dental caries susceptibility in an individual.

  20. Contribution to the study of elementary particles in experiments involving accelerators; Contribution a l'etude des constituants elementaires aupres des accelerateurs

    Energy Technology Data Exchange (ETDEWEB)

    Baldisseri, A

    2006-05-15

    This document reviews the theoretical, experimental and technical achievements of the author since the beginning of his scientific career. Works in 5 fields have been highlighted: 1) rare decays of the {eta} meson, 2) neutrino oscillations in NOMAD experiment, 3) quark and gluon plasma, 4) the PHENIX experiment at RHIC, and 5) the ALICE experiment in LHC. The PHENIX experiment was dedicated to the accurate measuring of photons and dileptons (particularly J/{psi}, {psi}' resonances) produced in heavy ion collisions. The ALICE experiment is devoted to the study of the quark gluon plasma. Its detector must be able to detect charged particles with a broad range of transverse momenta (from 100 MeV/c to 100 GeV/c). This document presented before an academic board will allow his author to manage research works and particularly to tutor thesis students.

  1. Two-pion Bose-Einstein correlations in Pb-Pb collisions at $\\sqrt{s_{NN}}$ = 2.76 TeV measured with the ALICE experiment

    CERN Document Server

    Gramling, Johanna Lena

    2012-01-01

    The measurement of pion source radii in Pb-Pb collisions with the ALICE experiment at LHC is presented. By the analysis of Bose-Einstein enhancement in the correlation function of identical pions information on the size and evolution of the source region in space-time can be obtained. The source radii observed at LHC are larger than at RHIC, approximately scaling with the cube root of the particle multiplicity. A decrease of source radii with increasing pair momentum, indicating a collective expansion of the medium, was observed at RHIC and SPS and is also expected at LHC energies. The ALICE data confirm this and provide strict constraints on dynamical models describing the medium expansion. The results suggest that the created fireball has a higher temperature and a longer lifetime as compared to lower energies.

  2. Correlated Topic Vector for Scene Classification.

    Science.gov (United States)

    Wei, Pengxu; Qin, Fei; Wan, Fang; Zhu, Yi; Jiao, Jianbin; Ye, Qixiang

    2017-07-01

    Scene images usually involve semantic correlations, particularly when considering large-scale image data sets. This paper proposes a novel generative image representation, correlated topic vector, to model such semantic correlations. Oriented from the correlated topic model, correlated topic vector intends to naturally utilize the correlations among topics, which are seldom considered in the conventional feature encoding, e.g., Fisher vector, but do exist in scene images. It is expected that the involvement of correlations can increase the discriminative capability of the learned generative model and consequently improve the recognition accuracy. Incorporated with the Fisher kernel method, correlated topic vector inherits the advantages of Fisher vector. The contributions to the topics of visual words have been further employed by incorporating the Fisher kernel framework to indicate the differences among scenes. Combined with the deep convolutional neural network (CNN) features and Gibbs sampling solution, correlated topic vector shows great potential when processing large-scale and complex scene image data sets. Experiments on two scene image data sets demonstrate that correlated topic vector improves significantly the deep CNN features, and outperforms existing Fisher kernel-based features.

  3. A primer of statistical methods for correlating parameters and properties of electrospun poly(L-lactide) scaffolds for tissue engineering--PART 1: design of experiments.

    Science.gov (United States)

    Seyedmahmoud, Rasoul; Rainer, Alberto; Mozetic, Pamela; Maria Giannitelli, Sara; Trombetta, Marcella; Traversa, Enrico; Licoccia, Silvia; Rinaldi, Antonio

    2015-01-01

    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from several parametric studies only render some partial insights that are hard to compare and generally miss the role of parameters interactions. To bridge this gap, this article (Part-1 of 2) features a case study on poly-L-lactide scaffolds to demonstrate how statistical methods such as design of experiments can quantitatively identify the correlations existing between key scaffold properties and control parameters, in a systematic, consistent, and comprehensive manner disentangling main effects from interactions. The morphological properties (i.e., fiber distribution and porosity) and mechanical properties (Young's modulus) are "charted" as a function of molecular weight (MW) and other electrospinning process parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also addressed. © 2014 Wiley Periodicals, Inc.

  4. A primer of statistical methods for correlating parameters and properties of electrospun poly(l -lactide) scaffolds for tissue engineering-PART 1: Design of experiments

    KAUST Repository

    Seyedmahmoud, Rasoul

    2014-03-20

    Tissue engineering scaffolds produced by electrospinning are of enormous interest, but still lack a true understanding about the fundamental connection between the outstanding functional properties, the architecture, the mechanical properties, and the process parameters. Fragmentary results from several parametric studies only render some partial insights that are hard to compare and generally miss the role of parameters interactions. To bridge this gap, this article (Part-1 of 2) features a case study on poly-l-lactide scaffolds to demonstrate how statistical methods such as design of experiments can quantitatively identify the correlations existing between key scaffold properties and control parameters, in a systematic, consistent, and comprehensive manner disentangling main effects from interactions. The morphological properties (i.e., fiber distribution and porosity) and mechanical properties (Young\\'s modulus) are "charted" as a function of molecular weight (MW) and other electrospinning process parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also addressed.

  5. Experiments and correlations of pressure loss coefficients for hexagonal arranged rod bundles (P/D > 1.02) with helical wire spacers in laminar and turbulent flows

    International Nuclear Information System (INIS)

    Marten, K.; Yonekawa, S.; Hoffmann, H.

    1987-05-01

    Advanced pressurized water reactors as well as sodium cooled fast reactors, in their breeding and absorber elements, use tightly packed rod bundles with hexagonally arranged rods. Helical wires or helical fins serve as spacers. The pressure loss coefficients of twelve bundles with helical wires were determined systematically in water experiments. High measuring accuracy was achieved by very precise fabrication of the bundles and the shroud as well as by investigations of the proper measuring techniques. The results show a dependency of the loss coefficients on the Reynolds number and on the P/D and H/D ratios of the bundles. These results together with available systematic experimental results of investigations at P/D > 1.1 were used to develop a correlation to determine the pressure loss coefficients of tightly and widely packed hexagonally arranged rod bundles with helical wire spacers. These correlations were used to recalculate and compare results of pressure loss investigations found in the literature; good agreement was demonstrated. Hence, calculation methods exist for a broad range of applications to determine the pressure loss coefficients of hexagonally arranged rod bundles with helical wires for spacers. (orig./HP) [de

  6. 2d Di-Hadron Correlations at $\\sqrt(s_NN)$ = 2.76 TeV using the ALICE Experiment

    CERN Document Server

    Piyarathna, Badrajee

    The Large Hadron Collider (LHC) at CERN Geneva, Switzerland, attempts to recreate the initial conditions at the beginning of our universe. Heavy ions ( 208 Pb ) are accelerated up to 0.999999 of the speed of the light and collided at sqrt(sNN) = 2.76 TeV (center of mass energy per nucleon) in order to recreate the initial energy density around 10^-6 s after the Big Bang. The theory of Quantum Chromo Dynamics (QCD) predicts the formation of a primordial nuclear matter phase known as Quark Gluon Plasma (QGP) under these experimental conditions. This dissertation focuses on studying this QCD medium using data from the `A Large Ion Collider Experiment' (ALICE). The study of two-dimensional two-particle correlations of emitted charged particles carries valuable time integrated information of the dynamical QCD medium. Long-range correlations between particles in angular and momentum space generally can be attributed to collective behavior, which is not found in a superposition of elementary collisions. The focus of...

  7. Facilitating interest and out-of-school engagement in science in secondary school girls: Increasing the effectiveness of the teaching for transformative experience in science model through parental involvement

    Science.gov (United States)

    Heddy, Benjamin Charles

    This study investigated the impact of adding a parental involvement intervention to the Teaching for Transformative Experience in Science (TTES) model in science courses (biology and chemistry) in an all-girl middle and high school (N = 89). Specifically, the goal was to increase out-of-school engagement, interest, parental involvement, and achievement. Analysis showed that TTES with the addition of a parent intervention (TTES+PI) facilitated more out-of-school engagement and parent involvement than a comparison. Furthermore, a high initial level of situational and individual interest was maintained in the TTES+PI condition; whereas both forms of interest decreased in the comparison. A content analysis of transformative experience journal entries suggested that when parents showed value for science concepts, students' experiential value increased. The results provide evidence that the addition of a parent intervention may increase the effectiveness of TTES and maintain girl's interest in science, which has theoretical and practical implications.

  8. The Neurogenetic Correlates of Consciousness

    Science.gov (United States)

    Grandy, John K.

    2013-09-01

    The neurogenetic correlates of consciousness (NgCC) is a new field of consciousness studies that focuses on genes that have an effect on or are involved in the continuum of neuron-based consciousness. A framework of consciousness based on the neural correlates of consciousness (NCC) has already been established by Francis Crick and Christof Kock. In this work I propose that there are NgCC underlying the NCC which are both active during the conscious experience. So how are genes involved? There are two significant connections between DNA and neurons that are involved in the conscious experience. First, any brain system can be adversely affected by underlying genetic abnormalities which can be expressed in an individual at birth, in adulthood, or later in life. Second, the DNA molecule does not lay dormant while the neuron runs on autopilot. DNA is active in translating and transcribing RNA and protein products that are utilized during neuron functioning. Without these products being continuously produced by the DNA during a conscious experience the neurons would cease to function correctly and be rendered unable to provide a continuum of human consciousness. Consequently, in addition to NCC, NgCC must be factored in when appreciating a conscious event. In this work I will discuss and explain some NgCC citing several examples.

  9. Photon correlation holography.

    Science.gov (United States)

    Naik, Dinesh N; Singh, Rakesh Kumar; Ezawa, Takahiro; Miyamoto, Yoko; Takeda, Mitsuo

    2011-01-17

    Unconventional holography called photon correlation holography is proposed and experimentally demonstrated. Using photon correlation, i.e. intensity correlation or fourth order correlation of optical field, a 3-D image of the object recorded in a hologram is reconstructed stochastically with illumination through a random phase screen. Two different schemes for realizing photon correlation holography are examined by numerical simulations, and the experiment was performed for one of the reconstruction schemes suitable for the experimental proof of the principle. The technique of photon correlation holography provides a new insight into how the information is embedded in the spatial as well as temporal correlation of photons in the stochastic pseudo thermal light.

  10. Carers' experiences of involvement in care planning: a qualitative exploration of the facilitators and barriers to engagement with mental health services.

    OpenAIRE

    Cree, Lindsey; Brooks, Helen L; Berzins, Kathryn; Fraser, Claire; Lovell, Karina; Bee, Penny

    2015-01-01

    BACKGROUND: Formal recognition and involvement of carers in mental health services has been the focus of recent policy and practice initiatives as well as being supported by carers themselves. However, carers still report feeling marginalised and distanced from services. A prominent theme is that that they are not listened to and their concerns are not taken seriously. Compared to service user views, the reasons underpinning carers' dissatisfaction with care-planning procedures have been rela...

  11. Lymph node involvement in gastric cancer for different tumor sites and T stage: Italian Research Group for Gastric Cancer (IRGGC) experience.

    Science.gov (United States)

    Di Leo, Alberto; Marrelli, Daniele; Roviello, Franco; Bernini, Marco; Minicozzi, AnnaMaria; Giacopuzzi, Simone; Pedrazzani, Corrado; Baiocchi, Luca Gian; de Manzoni, Giovanni

    2007-09-01

    The aim of lymphadenectomy is to clear all the metastatic nodes achieving a complete removal of the tumor; nevertheless, its role in gastric cancer has been very much debated. The frequency of node metastasis in each lymphatic station according to the International Gastric Cancer Association, was studied in 545 patients who underwent D2 or D3 lymphadenectomy from June 1988 to December 2002. Upper third early cancers have shown an involvement of N2 celiac nodes in 25%. In advanced cancers, there was a high frequency of metastasis in the right gastroepiploic (from 10% in T2 to 50% in T4) and in the paraaortic nodes (26% in T2, 32% in T3, 38 % in T4). N3 left paracardial nodes involvement was observed in an important share of middle third tumors (17% in T3, 36% in T4). Splenic hilum nodes metastasis were common in T3 and T4 cancers located in the upper (39%) and middle (17%) stomach. N2 nodal involvement was frequent in lower third advanced cancers. Metastasis in M left paracardial and short gastric nodes were observed in a small percentage of cases. Given the nodal diffusion in our gastric cancer patients, extended lymphadenectomy is still a rationale to obtain radical resection.

  12. Alternative-Specific and Case-Specific Factors Involved in the Decisions of Islamic School Teachers Affecting Teacher Retention: A Discrete Choice Experiment

    Science.gov (United States)

    Abd-El-Hafez, Alaa Karem

    2015-01-01

    Teacher retention is a concern in all educational sectors in America. It is of special importance to Islamic schools, which tend to lack the resources necessary in recruiting and training new teachers. This dissertation addressed this problem in full-time Islamic schools in New York State by conducting a discrete choice experiment, which reflects…

  13. An Appetitive Experience after Fear Memory Destabilization Attenuates Fear Retention: Involvement GluN2B-NMDA Receptors in the Basolateral Amygdala Complex

    Science.gov (United States)

    Ferrer Monti, Roque I.; Giachero, Marcelo; Alfei, Joaquín M.; Bueno, Adrián M.; Cuadra, Gabriel; Molina, Victor A.

    2016-01-01

    It is known that a consolidated memory can return to a labile state and become transiently malleable following reactivation. This instability is followed by a restabilization phase termed reconsolidation. In this work, we explored whether an unrelated appetitive experience (voluntary consumption of diluted sucrose) can affect a contextual fear…

  14. Involved, Invisible, Ignored: The Experiences of Lesbian, Gay, Bisexual and Transgender Parents and Their Children in Our Nation's K-12 Schools

    Science.gov (United States)

    Kosciw, Joseph G.; Diaz, Elizabeth M.

    2008-01-01

    Current estimates indicate that there are more than 7 million lesbian, gay, bisexual and transgender (LGBT) parents with school-age children in the United States, yet little is known about the experiences of this growing number of LGBT-headed families in schools across the country. In order to fill this crucial gap in our knowledge of LGBT issues…

  15. Improving neutron spectrometer performances through spatial and focusing effects: Investigation of spatial correlation focusing influence on the resolution in diffraction and phonon scattering experiments

    International Nuclear Information System (INIS)

    Popovici, M.

    1986-09-01

    A consistent treatment of the optics of three-axis spectrometers with curved perfect crystals, the gradient of lattice spacing accounted for, is presented. The mosaic crystal case is treated within the same computational scheme. From the computational point of view, the perfect crystals case is not the zero mosaic spread limit of the mosaic crystals case. The estimation of the residual line-widths in conditions of reciprocal-space focusing allows the discussion of the possibilities and limitations of using spatial correlation effects for improving spectrometer performances. A computer programme is presented which makes it possible to calculate both analytically and numerically the optimal arrangements and the deviations of the optimal parameter values. The optimization of parameters not involved in the analytically expressed reciprocal-space focusing conditions is also possible with this programme. The experimental results presented in this paper show that both the line-widths and the absolute intensities can also be described with reasonable accuracy for the perfect curved crystals case. It is shown experimentally that even at low-flux reactors one can obtain with the aid of perfect curved crystals good resolutions at measurable intensities which are generally higher than those obtainable in conventional spectrometers with flat mosaic crystals

  16. Transport properties in mixtures involving carbon dioxide at low and moderate density: test of several intermolecular potential energies and comparison with experiment

    Science.gov (United States)

    Moghadasi, Jalil; Yousefi, Fakhri; Papari, Mohammad Mehdi; Faghihi, Mohammad Ali; Mohsenipour, Ali Asghar

    2009-09-01

    It is the purpose of this paper to extract unlike intermolecular potential energies of five carbon dioxide-based binary gas mixtures including CO2-He, CO2-Ne, CO2-Ar, CO2-Kr, and CO2-Xe from viscosity data and compare the calculated potentials with other models potential energy reported in literature. Then, dilute transport properties consisting of viscosity, diffusion coefficient, thermal diffusion factor, and thermal conductivity of aforementioned mixtures are calculated from the calculated potential energies and compared with literature data. Rather accurate correlations for the viscosity coefficient of afore-cited mixtures embracing the temperature range 200 K < T < 3273.15 K is reproduced from the present unlike intermolecular potentials energy. Our estimated accuracies for the viscosity are to within ±2%. In addition, the calculated potential energies are used to present smooth correlations for other transport properties. The accuracies of the binary diffusion coefficients are of the order of ±3%. Finally, the unlike interaction energy and the calculated low density viscosity have been employed to calculate high density viscosities using Vesovic-Wakeham method.

  17. Transport properties in mixtures involving carbon dioxide at low and moderate density: test of several intermolecular potential energies and comparison with experiment

    Energy Technology Data Exchange (ETDEWEB)

    Moghadasi, Jalil; Yousefi, Fakhri [Shiraz University, Department of Chemistry, Shiraz (Iran); Papari, Mohammad Mehdi; Faghihi, Mohammad Ali [Shiraz University of Technology, Department of Chemistry, Shiraz (Iran); Mohsenipour, Ali Asghar [University of Waterloo, Department of Chemical Engineering, Waterloo (Canada)

    2009-09-15

    It is the purpose of this paper to extract unlike intermolecular potential energies of five carbon dioxide-based binary gas mixtures including CO{sub 2}-He, CO{sub 2}-Ne, CO{sub 2}-Ar, CO{sub 2}-Kr, and CO{sub 2}-Xe from viscosity data and compare the calculated potentials with other models potential energy reported in literature. Then, dilute transport properties consisting of viscosity, diffusion coefficient, thermal diffusion factor, and thermal conductivity of aforementioned mixtures are calculated from the calculated potential energies and compared with literature data. Rather accurate correlations for the viscosity coefficient of afore-cited mixtures embracing the temperature range 200 Kcorrelations for other transport properties. The accuracies of the binary diffusion coefficients are of the order of {+-}3%. Finally, the unlike interaction energy and the calculated low density viscosity have been employed to calculate high density viscosities using Vesovic-Wakeham method. (orig.)

  18. Territories climate plans: territories in action 21 collectivities involved in the climatic change challenge. 1. experiences collection 2007; Plans climat territoriaux: des territoires en action 21 collectivites engagees dans la releve du defi climatique. 1. recueil d'experiences 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    The climate plan invites the collectivities to implement actions of greenhouse reduction. This collection presents the first collectivities involved in a climate approach: towns, natural parks, syndicates, general and regional council. (A.L.B.)

  19. Predictors of Substance Abuse Assessment and Treatment Completion for Parents Involved with Child Welfare: One State's Experience in Matching across Systems.

    Science.gov (United States)

    Traube, Dorian E; He, Amy S; Zhu, Limei; Scalise, Christine; Richardson, Tyrone

    2015-01-01

    To date, few studies have examined the effect of interagency collaboration on substance abuse assessment ity of Southern California and treatment completion for parents who are involved in child welfare. The purpose of this paper is to: (1) describe a statewide, interagency collaborative program aimed at providing targeted substance abuse assessment and treatment to parents engaged in the child welfare system; (2) document the specialized assessment and treatment outcomes for parents engaged through this collaborative program; and (3) determine factors related to successful treatment completion for parents involved in the child welfare system. This is a retrospective study of an open cohort of 13,829 individuals admitted to the New Jersey Child Protection Substance Abuse Initiative (CPSAI) program from October 1, 2009, through September 30, 2010. Data were drawn from two unique administrative data sources. Multivariate Cox regression models were used to explore factors related to successfil treatment completion for parents involved in the child welfare system. Trend analysis for the total sample in the CPSAI program revealed that, of the 10,909 individuals who received a CPSAI assessment, 59% were referred to treatment. Of those referred to treatment, 40% enrolled in a treatment program. Once enrolled in a treatment program, 55% completed or were in the process of completing substance abuse treatment. These findings suggest that when adequate screening and treatment is available through a streamlined process, many of the ethnic and gender disparities present among other populations of individuals seeking treatment are minimized. Utilizing inherent child welfare case factors appears to be an important motivating element that aids parents during the assessment and treatment process.

  20. The TOMO-ETNA experiment: an imaging active campaign at Mt. Etna volcano. Context, main objectives, working-plans and involved research projects

    Directory of Open Access Journals (Sweden)

    Jesús M. Ibáñez

    2016-09-01

    Full Text Available The TOMO-ETNA experiment was devised to image of the crust underlying the volcanic edifice and, possibly, its plumbing system by using passive and active refraction/reflection seismic methods. This experiment included activities both on-land and offshore with the main objective of obtaining a new high-resolution seismic tomography to improve the knowledge of the crustal structures existing beneath the Etna volcano and northeast Sicily up to Aeolian Islands. The TOMO ETNA experiment was divided in two phases. The first phase started on June 15, 2014 and finalized on July 24, 2014, with the withdrawal of two removable seismic networks (a Short Period Network and a Broadband network composed by 80 and 20 stations respectively deployed at Etna volcano and surrounding areas. During this first phase the oceanographic research vessel “Sarmiento de Gamboa” and the hydro-oceanographic vessel “Galatea” performed the offshore activities, which includes the deployment of ocean bottom seismometers (OBS, air-gun shooting for Wide Angle Seismic refraction (WAS, Multi-Channel Seismic (MCS reflection surveys, magnetic surveys and ROV (Remotely Operated Vehicle dives. This phase finished with the recovery of the short period seismic network. In the second phase the Broadband seismic network remained operative until October 28, 2014, and the R/V “Aegaeo” performed additional MCS surveys during November 19-27, 2014. Overall, the information deriving from TOMO-ETNA experiment could provide the answer to many uncertainties that have arisen while exploiting the large amount of data provided by the cutting-edge monitoring systems of Etna volcano and seismogenic area of eastern Sicily.

  1. Involving women.

    Science.gov (United States)

    Agbo, J

    1994-01-01

    I am a primary health care (PHC) coordinator working with the May Day Rural project, a local NGO involved in integrated approaches and programs with rural communities in the Ga District of the Greater-Accra region in Ghana. When we talk about the community development approach we must first and foremost recognize that we are talking about women, because in the developing world frequent childbirths mean that her burden of mortality is higher than a man's; her workload is extremely heavy--whether in gardening, farming, other household duties, caring for the sick, or the rearing of children; she has a key role in PHC and community development, because men are always looking for greener pastures elsewhere, leaving the women behind. Women's concerns are critical in most health care projects and women and children are their main beneficiaries. Why not include women in the management team, project design, implementation and evaluation processes? That is what the May Day Rural project is practicing, encouraging women's participation and creating a relationship of trust. full text

  2. Contribution of the microprocessors in the study and development of a pre-processing unit involved in a nuclear physics experiment

    International Nuclear Information System (INIS)

    Pichot, G.

    1980-01-01

    The pre-processing unit has its place between the electronic output of the detector and the experiment control system, its role is 3-fold: a real-time role to provide adequate data to the control system allowing feedback, a basic role of selecting and reducing the volume of data and a role of managing the programs necessary to the first 2 roles. This work can be divided in 3 parts. First the analysis of the needs and limitations of the present system, secondly the meeting of the needs with on-the-shelf equipment, and thirdly validation and future improvements [fr

  3. Weak mixing and CP violation involving heavy quarks and possible measurements in e/sup +/e/sup -/ experiments. [Higgs exchange mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Ali, A; Aydin, Z Z [Hamburg Univ. (Germany, F.R.). 2. Inst. fuer Theoretische Physik

    1979-01-01

    The authors evaluate weak mass mixing among the neutral heavy mesons with a bottom (Q=-1/3) or top (Q=+2/3) quark and CP violation in this framework of six quark V-A models. It is argued that bottom and top mesons may distinguish the Higgs exchange mechanism of CP violation from a complex phase in the quark mass matrix, if bottom and top quark masses are sufficiently different. Estimates of weak mixing and CP violating effects for e/sup +/e/sup -/ experiments at PETRA, PEP and CESR energies are presented.

  4. First experience of simultaneous PET/MRI for the early detection of cardiac involvement in patients with Anderson-Fabry disease

    International Nuclear Information System (INIS)

    Nappi, Carmela; Altiero, Michele; Imbriaco, Massimo; Giudice, Caterina Anna; Spinelli, Letizia; Cuocolo, Alberto; Nicolai, Emanuele; Aiello, Marco; Diomiaiuti, Claudio Tommaso; Pisani, Antonio

    2015-01-01

    Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder associated with severe multiorgan dysfunction and premature death. Early diagnosis and treatment strategies play a key role in patient outcome. We investigated the potential role of hybrid PET/MR imaging in the assessment of early cardiac involvement in AFD patients. Thirteen AFD patients without cardiac symptoms and with normal left ventricular function underwent simultaneous cardiac PET/MR imaging after administration of 18 F-FDG. Cardiac FDG uptake was quantified by measuring the standardized uptake value in 17 myocardial segments in each subject. The coefficient of variation (COV, i.e. the standard deviation divided by the average) of the uptake of the 17 segments was calculated as an index of heterogeneity in the heart. Six patients exhibited focal late gadolinium enhancement (LGE) indicating intramyocardial fibrosis, and four of these also had positive short inversion time inversion recovery (STIR) sequences. All patients with LGE and positive STIR MR images showed focal FDG uptake in the corresponding myocardial segments indicating inflammation. Of the seven patients with negative LGE and STIR images, five showed homogeneous FDG cardiac uptake and two showed heterogeneous FDG uptake. The COV was significantly greater in patients with focal FDG uptake (0.25 ± 0.02) than in those without (0.14 ± 0.07, p < 0.01). PET/MR imaging is clinically feasible for the early detection of cardiac involvement in patients with AFD. Further studies evaluating the role of hybrid PET/MR imaging in management of the disease in larger patient populations are warranted. (orig.)

  5. Instantaneous exposure to nuclear medicine staff involved in PET-CT imaging in developing countries. Experience from a tertiary care centre in India

    International Nuclear Information System (INIS)

    Kumar, S.; Sharma, P.; Shamim, S.A.; Malhotra, A.; Kumar, R.; Pandey, A.K.

    2012-01-01

    The purpose of this study was to assess the radiation exposure to nuclear medicine staff at a positron emission tomography-computed tomography (PET-CT) centre with high patient throughput. This prospective study included 70 adult patients who underwent 18F-fluorodeoxyglucose (FDG) PET-CT for their clinical indications. The patients' actual injected FDG activity was calculated by subtracting the syringe activity (post-injection) from the loaded syringe activity (pre-injection). The instantaneous exposure to nuclear medicine staff involved in PET-CT imaging was measured. The instantaneous dose rate of the physicians was recorded during FDG injection and that of the technologist was recorded during the patient's positioning, respectively, at 1.0-m distance from the anterior chest using a calibrated portable gamma-ray survey meter. The average FDG activity injected in adult patients was 308.5 MBq (range 173.1-438.8 MBq). The instantaneous exposure to the nuclear medicine (NM) physician during the injection time was 31 μSv/h (14-60 μSv/h). The instantaneous exposure to the NM technologist during positioning was 18 (10-34) μSv/h. With an average of 10 patients per day, the quarterly dose to physicians was 628 μSv and to technologists 182 μSv for 300 patients. The extrapolated annual dose was 2.5 mSv for physicians and 0.7 mSv for technologists, respectively. Instantaneous exposure of nuclear medicine staff involved in PET-CT imaging at a busy tertiary care centre is within permissible limits of the International Commission on Radiological Protection (ICRP-103) (total 50 mSv in a single year) and atomic energy regulatory board (total 30 mSv in a single year). (author)

  6. First experience of simultaneous PET/MRI for the early detection of cardiac involvement in patients with Anderson-Fabry disease

    Energy Technology Data Exchange (ETDEWEB)

    Nappi, Carmela; Altiero, Michele; Imbriaco, Massimo; Giudice, Caterina Anna; Spinelli, Letizia; Cuocolo, Alberto [University Federico II, Department of Advanced Biomedical Sciences, Naples (Italy); Nicolai, Emanuele; Aiello, Marco; Diomiaiuti, Claudio Tommaso [IRCCS SDN, Naples (Italy); Pisani, Antonio [University Federico II, Department of Public Health, Naples (Italy)

    2015-03-26

    Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder associated with severe multiorgan dysfunction and premature death. Early diagnosis and treatment strategies play a key role in patient outcome. We investigated the potential role of hybrid PET/MR imaging in the assessment of early cardiac involvement in AFD patients. Thirteen AFD patients without cardiac symptoms and with normal left ventricular function underwent simultaneous cardiac PET/MR imaging after administration of {sup 18}F-FDG. Cardiac FDG uptake was quantified by measuring the standardized uptake value in 17 myocardial segments in each subject. The coefficient of variation (COV, i.e. the standard deviation divided by the average) of the uptake of the 17 segments was calculated as an index of heterogeneity in the heart. Six patients exhibited focal late gadolinium enhancement (LGE) indicating intramyocardial fibrosis, and four of these also had positive short inversion time inversion recovery (STIR) sequences. All patients with LGE and positive STIR MR images showed focal FDG uptake in the corresponding myocardial segments indicating inflammation. Of the seven patients with negative LGE and STIR images, five showed homogeneous FDG cardiac uptake and two showed heterogeneous FDG uptake. The COV was significantly greater in patients with focal FDG uptake (0.25 ± 0.02) than in those without (0.14 ± 0.07, p < 0.01). PET/MR imaging is clinically feasible for the early detection of cardiac involvement in patients with AFD. Further studies evaluating the role of hybrid PET/MR imaging in management of the disease in larger patient populations are warranted. (orig.)

  7. Investigation into magnetic correlations in cuprates by means of neutron scattering experiments; Untersuchung magnetischer Korrelationen in Kupraten mit Hilfe von Neutronenstreuexperimenten

    Energy Technology Data Exchange (ETDEWEB)

    Henggeler, W [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-12-31

    Cuprate materials containing rare earth ions were studied. The main experimental tools were inelastic and elastic neutron scattering techniques. Some {mu}SR, susceptibility and specific heat measurements were also performed. One aim was to learn more about the crystalline environment of the rare earth ions in these substances via the crystalline electric field (CEF) interaction. Furthermore, we investigated the correlations of the magnetic moments of these ions by a determination of the dispersion of the CEF excitations. The theory that is essential for the understanding of this work is outlined. The instruments on which the experiments have been performed are presented. We show the measurements of the CEF excitations of Ho{sup 3+} in Y{sub 0.99}Ho{sub 0.01}Ba{sub 2}Cu{sub 3}O{sub 6+x}. The Ho ions represent ideal local probes to examine changes of the charge distribution in the copper oxide planes upon doping with oxygen. To prevent any influence of the Ho-Ho exchange interaction on the CEF excitations we performed the experiments on substances containing only one percent of Ho. Our results show that for all the intermediately doped compounds the charge distribution is very inhomogeneous. For all the highly doped samples we observe a line asymmetry for which several possible origins are discussed. We examine the Pr{sup 3+} CEF excitations in the Pr{sub 2-x}Ce{sub x}CuO{sub 4(-{delta})} (0{<=}x{<=}0.2)-substances. Our results show a coexistence of different environments of the Pr ions in all the doped compounds. We try to describe these inhomogeneities with the help of a model. We used the {mu}SR-technique on some of these samples in order to learn more about the oxygen reduction process. Finally, we performed inelastic neutron scattering experiments on Pr{sub 1.86}Ce{sub 0.14}CuO{sub 4} single crystal, which allowed a direct determination of the coupling constants between the magnetic moments of the Pr ions. (author) figs., tabs., 93 refs.

  8. Investigation into magnetic correlations in cuprates by means of neutron scattering experiments; Untersuchung magnetischer Korrelationen in Kupraten mit Hilfe von Neutronenstreuexperimenten

    Energy Technology Data Exchange (ETDEWEB)

    Henggeler, W. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1996-12-31

    Cuprate materials containing rare earth ions were studied. The main experimental tools were inelastic and elastic neutron scattering techniques. Some {mu}SR, susceptibility and specific heat measurements were also performed. One aim was to learn more about the crystalline environment of the rare earth ions in these substances via the crystalline electric field (CEF) interaction. Furthermore, we investigated the correlations of the magnetic moments of these ions by a determination of the dispersion of the CEF excitations. The theory that is essential for the understanding of this work is outlined. The instruments on which the experiments have been performed are presented. We show the measurements of the CEF excitations of Ho{sup 3+} in Y{sub 0.99}Ho{sub 0.01}Ba{sub 2}Cu{sub 3}O{sub 6+x}. The Ho ions represent ideal local probes to examine changes of the charge distribution in the copper oxide planes upon doping with oxygen. To prevent any influence of the Ho-Ho exchange interaction on the CEF excitations we performed the experiments on substances containing only one percent of Ho. Our results show that for all the intermediately doped compounds the charge distribution is very inhomogeneous. For all the highly doped samples we observe a line asymmetry for which several possible origins are discussed. We examine the Pr{sup 3+} CEF excitations in the Pr{sub 2-x}Ce{sub x}CuO{sub 4(-{delta})} (0{<=}x{<=}0.2)-substances. Our results show a coexistence of different environments of the Pr ions in all the doped compounds. We try to describe these inhomogeneities with the help of a model. We used the {mu}SR-technique on some of these samples in order to learn more about the oxygen reduction process. Finally, we performed inelastic neutron scattering experiments on Pr{sub 1.86}Ce{sub 0.14}CuO{sub 4} single crystal, which allowed a direct determination of the coupling constants between the magnetic moments of the Pr ions. (author) figs., tabs., 93 refs.

  9. Experience-based knowledge in nuclear and radiological emergency preparedness - involvement of national stake holders. Report from the EURANOS project; Erfaringsbasert kunnskap i norsk atomberedskap - medvirkning fra beroerte parter. Rapport fra EURANOS-prosjektet

    Energy Technology Data Exchange (ETDEWEB)

    Bay-Larsen, I.; Oughton, D.; Liland, A.; Eikelmann, I.M.; Hansen, H.S.

    2009-05-15

    The report identifies and summarises the most important experiences related to long term rehabilitation of contaminated areas after the Chernobyl accident, as phrased by representatives from the agricultural sector (including reindeer herding), primary health care, academia, NGOs, local and regional authorities, as well as national authorities with responsibilities for emergency preparedness within their sector. It also includes recommendations for future collaboration to ensure competence and stake holder involvement in Norwegian nuclear and radiological emergency preparedness. (Author)

  10. Effects of an early experience involving training in a T-maze under either denial or receipt of expected reward through maternal contact.

    Directory of Open Access Journals (Sweden)

    Antonios eStamatakis

    2013-11-01

    Full Text Available The mother is the most salient stimulus for the developing pups and a number of early experience models employ manipulation of the mother-infant interaction. We have developed a new model which in addition to changes in maternal behavior includes a learning component on the part of the pups. More specifically, pups were trained in a T-maze and either received (RER rats or were denied (DER the reward of maternal contact, during postnatal days 10—13.Pups of both experimental groups learn the T-maze, but the RER do so more efficiently utilizing a procedural-type of learning and memory with activation of the dorsal basal ganglia. On the other hand, the DER experience leads to activation of the hippocampus, prefrontal cortex and amygdala in the pups.In adulthood, male DER animals exhibit better mnemonic abilities in the Morris water maze and higher activation of the hippocampus, while they have decreased brain serotonergic activity, exhibit a depressive-like phenotype and proactive aggressive behavior in the resident-intruder test. On the other hand, male RER animals assume a reactive coping style in this test, showed increased emotionality as well as freezing in the memory test following both contextual and cued fear conditioning.

  11. Older patients with late-stage COPD: Their illness experiences and involvement in decision-making regarding mechanical ventilation and noninvasive ventilation.

    Science.gov (United States)

    Jerpseth, Heidi; Dahl, Vegard; Nortvedt, Per; Halvorsen, Kristin

    2018-02-01

    To explore the illness experiences of older patients with late-stage chronic obstructive pulmonary disease and to develop knowledge about how patients perceive their preferences to be taken into account in decision-making processes concerning mechanical ventilation and/or noninvasive ventilation. Decisions about whether older patients with late-stage chronic obstructive pulmonary disease will benefit from noninvasive ventilation treatment or whether the time has come for palliative treatment are complicated, both medically and ethically. Knowledge regarding patients' values and preferences concerning ventilation support is crucial yet often lacking. Qualitative design with a hermeneutic-phenomenological approach. The data consist of qualitative in-depth interviews with 12 patients from Norway diagnosed with late-stage chronic obstructive pulmonary disease. The data were analysed within the three interpretative contexts described by Kvale and Brinkmann. The participants described their lives as fragile and burdensome, frequently interrupted by unpredictable and frightening exacerbations. They lacked information about their diagnosis and prognosis and were often not included in decisions about noninvasive ventilation or mechanical ventilation. Findings indicate that these patients are highly vulnerable and have complex needs in terms of nursing care and medical treatment. Moreover, they need access to proactive advanced care planning and an opportunity to discuss their wishes for treatment and care. To provide competent care for these patients, healthcare personnel must be aware of how patients experience being seriously ill. Advanced care planning and shared decision-making should be initiated alongside the curative treatment. © 2017 John Wiley & Sons Ltd.

  12. Influence of Involvement in Sports on Students' Involvement in ...

    African Journals Online (AJOL)

    This study was carried out to establish whether students' involvement in sports activities affected their involvement in academic activities. Data were collected using a self-administered questionnaire and analysed using percentages and means. Spearman's correlation coefficient was used to test the hypotheses that guided ...

  13. Intentional minds: A philosophical analysis of intention tested through fMRI experiments involving people with schizophrenia, people with autism, and healthy individuals.

    Directory of Open Access Journals (Sweden)

    Bruno G Bara

    2011-02-01

    Full Text Available In this paper we show how we empirically tested one of the most relevant topics in philosophy of mind through a series of fMRI experiments: the classification of different types of intention. To this aim, firstly we trace a theoretical distinction among private, prospective and communicative intentions. Second, we propose a set of predictions concerning the recognition of these three types of intention in healthy individuals, and we report the experimental results corroborating our theoretical model of intention. Third, we derive from our model predictions relevant for the domain of psychopathological functioning. In particular, we treat the cases of both hyper-intentionality (as in paranoid schizophrenia and hypo-intentionality (as in autistic spectrum disorders. Our conclusion is that the theoretical model of intention we propose contributes to enlarge our knowledge on the neurobiological bases of intention processing, in both healthy people and in people with impairments to the neurocognitive system that underlies intention recognition.

  14. BNFL's experience in preparing and implementing radiation protection programmes for the control of exposure to workers involved with the international transport of nuclear cargoes

    International Nuclear Information System (INIS)

    Billing, D.

    2004-01-01

    BNFL International Transport have successfully developed appropriate Radiation Protection Programmes for their business. The business supports BNFL's worldwide Nuclear Fuel Services with key customer bases in Europe, Japan and the UK, utilising marine, rail and road modal transports. Experience in the business spans over 4 decades. The preparation of RPP's for each aspect of its operations has been made relatively straight forward in that the key elements within the internationally recognised model RPP (by WNTI) were already in place in BNFL's procedures to satisfy current National UK and International Regulations. Arrangements are supported by Management systems which comply with International Standards for Quality Assurance. Exposure to key worker groups continues to be within Category 1 (less than 1mSv/y) of the IAEA Transport Regulations TS-R-1 (ST-1 revised)

  15. Intentional Minds: A Philosophical Analysis of Intention Tested through fMRI Experiments Involving People with Schizophrenia, People with Autism, and Healthy Individuals.

    Science.gov (United States)

    Bara, Bruno G; Ciaramidaro, Angela; Walter, Henrik; Adenzato, Mauro

    2011-01-01

    IN THIS PAPER WE SHOW HOW WE EMPIRICALLY TESTED ONE OF THE MOST RELEVANT TOPICS IN PHILOSOPHY OF MIND THROUGH A SERIES OF FMRI EXPERIMENTS: the classification of different types of intention. To this aim, firstly we trace a theoretical distinction among private, prospective, and communicative intentions. Second, we propose a set of predictions concerning the recognition of these three types of intention in healthy individuals, and we report the experimental results corroborating our theoretical model of intention. Third, we derive from our model predictions relevant for the domain of psychopathological functioning. In particular, we treat the cases of both hyper-intentionality (as in paranoid schizophrenia) and hypo-intentionality (as in autistic spectrum disorders). Our conclusion is that the theoretical model of intention we propose contributes to enlarge our knowledge on the neurobiological bases of intention processing, in both healthy people and in people with impairments to the neurocognitive system that underlies intention recognition.

  16. Implementation and assessment of a yeast orphan gene research project: involving undergraduates in authentic research experiences and progressing our understanding of uncharacterized open reading frames.

    Science.gov (United States)

    Bowling, Bethany V; Schultheis, Patrick J; Strome, Erin D

    2016-02-01

    Saccharomyces cerevisiae was the first eukaryotic organism to be sequenced; however, little progress has been made in recent years in furthering our understanding of all open reading frames (ORFs). From October 2012 to May 2015 the number of verified ORFs had only risen from 75.31% to 78%, while the number of uncharacterized ORFs had decreased from 12.8% to 11% (representing > 700 genes still left in this category; http://www.yeastgenome.org/genomesnapshot). Course-based research has been shown to increase student learning while providing experience with real scientific investigation; however, implementation in large, multi-section courses presents many challenges. This study sought to test the feasibility and effectiveness of incorporating authentic research into a core genetics course, with multiple instructors, to increase student learning and progress our understanding of uncharacterized ORFs. We generated a module-based annotation toolkit and utilized easily accessible bioinformatics tools to predict gene function for uncharacterized ORFs within the Saccharomyces Genome Database (SGD). Students were each assigned an uncharacterized ORF, which they annotated using contemporary comparative genomics methodologies, including multiple sequence alignment, conserved domain identification, signal peptide prediction and cellular localization algorithms. Student learning outcomes were measured by quizzes, project reports and presentations, as well as a post-project questionnaire. Our results indicate that the authentic research experience had positive impacts on students' perception of their learning and their confidence to conduct future research. Furthermore, we believe that creation of an online repository and adoption and/or adaptation of this project across multiple researchers and institutions could speed the process of gene function prediction. Copyright © 2015 John Wiley & Sons, Ltd.

  17. Evidence to inform education, training and supportive work environments for midwives involved in the care of women with female genital mutilation: a review of global experience.

    Science.gov (United States)

    Dawson, Angela; Turkmani, Sabera; Fray, Shairon; Nanayakkara, Susie; Varol, Nesrin; Homer, Caroline

    2015-01-01

    to identify how midwives in low and middle income countries (LMIC) and high income countries (HIC) care for women with female genital mutilation (FGM), their perceived challenges and what professional development and workplace strategies might better support midwives to provide appropriate quality care. an integrative review involving a narrative synthesis of the literature was undertaken to include peer reviewed research literature published between 2004 and 2014. 10 papers were included in the review, two from LMIC and eight from HIC. A lack of technical knowledge and limited cultural competency was identified, as well as socio-cultural challenges in the abandonment process of the practice, particularly in LMIC settings. Training in the area of FGM was limited. One study reported the outcomes of an education initiative that was found to be beneficial. professional education and training, a working environment supported by guidelines and responsive policy and community education, are necessary to enable midwives to improve the care of women with FGM and advocate against the practice. improved opportunities for midwives to learn about FGM and receive advice and support, alongside opportunities for collaborative practice in contexts that enable the effective reporting of FGM to authorities, may be beneficial and require further investigation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Involvement of N6 and N3 polyunsaturated faty acids on the lipidic profile in central nervous system of the animals of experience

    Directory of Open Access Journals (Sweden)

    G. Iamandei1, Veronica Mocanu1, T. Oboroceanu2, Veronica Luca1

    2010-11-01

    Full Text Available AbstractIntroduction: N-3 and N-6polyunsaturated fatty acids has manyinvolvements in activities within orentering in regulating various physiologicalprocesses and in certain pathologies.Among systemic physiological effects inwhich they are involved we mention thecentral nervous system development andrecall of the retina, regulating plasma lipidlevels, cardiovascular and immune systemfunctions, regulating the activity of insulin.Material and methods: The experimentthere were used 60 male Wistar rats , weight180 ± 20 grams, procured from the animalfarm of the Department ofPathophysiology, University of Medicineand Pharmacy “Gr.T. Popa”, Iaşi.Male Wistar rats were divided into twostudy groups: normal control animals (Mand test animals.Test group was further divided intothree groups - each group being composedof 15 animals.Administration of the substances wasmade for 36 weeks (nine months, afterwhich the animals were evaluated andsubsequently sacrificed.Results: Following statistical analysis, wedetermined the following:• Averages of AGP n3 were significantlyhigher in groups 2 (p <0.001 and 3 (p<0.001 compared with group 4• Averages ratio n6: n3 in nerve cellmembrane were significantly lower ingroups 2 (p <0.001 and 3 (p <0.001compared with group 4Discussions: Our experimentdemonstrates that increased amounts ofpolyunsaturated fatty acids in themembranes of nerve cells which can justifythe positive evolution of animals inassessing the performance of concomitantbehavioral tests.Conclusions: This study brings new lighton the importance of the existence of abalance between PUFA intake and dailydiet.

  19. Realization of two light particle correlation experiments: behaviour to very low relative momenta (measurement with a magnetic spectrometer) and influence of the violence of reaction on the emission sources (measured by the neutron detector ORION

    International Nuclear Information System (INIS)

    Sezac, L.

    1993-01-01

    The correlation measurements between light particles emitted during heavy ion collisions allow to estimate the time-space extension of the emitting sources. This report about the preliminaries of two correlation experiments is split into two parts. The first one describes a test experiment, performed to study the feasibility of a correlation experiment at very low relative momenta with the help of a magnetic spectrometer. The results will allow to determine the still unknown relative effects from the final state interaction and the combination of both Coulomb interaction and quantum statistics. A correlation study without experimental selection of the impact parameter gives unclear answers about the sizes and the temporal characteristics of the emitting systems. The second part analyses the sources of the alpha particles detected in the reaction chamber of the multidetector ORION used as a violence of the reaction filter. The results show that it is possible to consider as a good filter a fast information called 'prompt peak' (correlated to the neutron multiplicity detected with ORION). Under such conditions a study of two particle correlations from equilibrated systems with a reasonable statistics becomes thinkable. The results obtained allow to characterize the emitting sources (speed, intensity, temperature) as a function of the violence of the reaction for the system 208 Pb + 93 Nb at 29 MeV/u. (author)

  20. Lack of survival improvement with novel anti-myeloma agents for patients with multiple myeloma and central nervous system involvement: the Greek Myeloma Study Group experience.

    Science.gov (United States)

    Katodritou, Eirini; Terpos, Evangelos; Kastritis, Efstathios; Delimpasis, Sossana; Symeonidis, Argiris S; Repousis, Panagiotis; Kyrtsonis, Marie-Christine; Vadikolia, Chrysa; Michalis, Eurydiki; Polychronidou, Genovefa; Michael, Michael; Papadaki, Sofia; Papathanasiou, Maria; Kokoviadou, Kyriaki; Kioumi, Anna; Vlachaki, Eythimia; Hadjiaggelidou, Christina; Kouraklis, Alexandra; Patsias, Ioannis; Gavriatopoulou, Maria; Kotsopoulou, Maria; Verrou, Evgenia; Gastari, Vasiliki; Christoulas, Dimitrios; Giannopoulou, Evlambia; Pouli, Anastasia; Konstantinidou, Pavlina; Anagnostopoulos, Achilles; Dimopoulos, Meletios-Athanasios

    2015-12-01

    Involvement of the central nervous system (CNS) is a rare complication of multiple myeloma (MM). Herein, we have described the incidence, characteristics, prognostic factors for post CNS-MM survival, and outcome of CNS-MM and explored the efficacy of novel agents (NA) (thalidomide, bortezomib, lenalidomide) in this setting. Between 2000 and 2013, 31 (0.9 %) out of 3408 newly diagnosed symptomatic MM patients, consecutively diagnosed and treated during the same period in 12 Greek centers, developed CNS-MM (M/F 15/16, median age 59 years, range 20-96 years; newly diagnosed/relapsed-refractory 2/29; median time to CNS-MM diagnosis 29 months). Clinical and laboratory characteristics were retrospectively recorded. Twenty-six percent of patients had circulating plasma cells (PCs) or plasma cell leukemia (PCL) at CNS-MM and 39 % had skull-derived plasmacytomas, suggesting hematological and contiguous spread. Treatment for CNS-MM was offered in 29/31 patients and 11/29 responded (NA 18/29, additional radiotherapy 9/28, intrathecal chemotherapy 13/29). The median post CNS-MM survival was 3 months (95 % CI 1.9-4.1) and did not differ between patients treated with NA and/or radiotherapy vs. others. In the multivariate analysis, prior treatment of MM with NA, extramedullary disease (EMD) during MM course (i.e., plasmacytomas, circulating PCs, or documented PCL) and abnormally high LDH at MM diagnosis were independent prognostic factors, whereas treatment of CNS-MM with NA did not predict for post CNS-MM survival. Despite the relatively limited number of patients due to the rarity of CNS-MM, our results suggest that NA do not seem to improve post CNS-MM survival. Patients with EMD display shortened post CNS-MM survival and should be followed thoroughly.

  1. Parental Involvement and Academic Achievement

    Science.gov (United States)

    Goodwin, Sarah Christine

    2015-01-01

    This research study examined the correlation between student achievement and parent's perceptions of their involvement in their child's schooling. Parent participants completed the Parent Involvement Project Parent Questionnaire. Results slightly indicated parents of students with higher level of achievement perceived less demand or invitations…

  2. A single institution experience with the new bethesda system for reporting thyroid cytopathology: correlation with existing cytologic, clinical, and histological data.

    Science.gov (United States)

    McElroy, Michele K; Mahooti, Sepi; Hasteh, Farnaz

    2014-07-01

    Our goal was to evaluate the Bethesda system (TBS) in comparison to the previously used system at our institution. One hundred consecutive thyroid fine needle aspirations (FNAs) and 45 consecutive indeterminate FNAs were reviewed by two cytopathology-boarded pathologists, diagnosed based on TBS and correlated with management and follow-up. Re-evaluation led to a diagnosis change in 48% of cases. Thirty-nine percent of benign cases were unsatisfactory under TBS. For malignant diagnoses the positive predictive value (PPV) was unchanged, while the negative predictive value (NPV) was slightly improved using TBS. Both the PPV and NPV were improved for actionable diagnoses. Inter-observer variability across all categories was in moderate agreement. Clinical management of both follicular lesion (FL) and indeterminate cases ranged from none to immediate surgery. Repeat FNA resolved the diagnosis in 50% of indeterminate cases. Indeterminate cases had an overall malignancy rate of 27%; higher in pre- (46%) than post-TBS cases (8%). Inter-observer variability between the reviewing pathologists and the original pathologists for indeterminate cases was fair, and between the two reviewing pathologists was moderate. Using TBS criteria increased the unsatisfactory rate and led to improved prediction of malignancy and actionable diagnoses. The pre-Bethesda diagnosis of FL at our institution led to inconsistent clinical management. Clinical management of patients with indeterminate diagnoses was essentially unchanged following adoption of TBS. The moderate inter-observer agreement between the reviewing pathologists may be related to level of cytology experience, strict adherence to TBS, and the exclusive use of cytomorphology for diagnosis. © 2014 Wiley Periodicals, Inc.

  3. Field experiment for determining lead accumulation in rice grains of different genotypes and correlation with iron oxides deposited on rhizosphere soil.

    Science.gov (United States)

    Lai, Yu-Cheng; Syu, Chien-Hui; Wang, Pin-Jie; Lee, Dar-Yuan; Fan, Chihhao; Juang, Kai-Wei

    2018-01-01

    Paddy rice (Oryza sativa L.) is a major staple crop in Asia. However, heavy metal accumulation in paddy soil poses a health risk for rice consumption. Although plant uptake of Pb is usually low, Pb concentrations in rice plants have been increasing with Pb contamination in paddy fields. It is known that iron oxide deposits in the rhizosphere influence the absorption of soil Pb by rice plants. In this study, 14 rice cultivars bred in Taiwan, including ten japonica cultivars (HL21, KH145, TC192, TK9, TK14, TK16, TN11, TNG71, TNG84, and TY3) and four indica cultivars (TCS10, TCS17, TCSW2, and TNGS22), were used in a field experiment. We investigated the genotypic variation in rice plant Pb in relation to iron oxides deposited in the rhizosphere, as seen in a suspiciously contaminated site in central Taiwan. The results showed that the cultivars TCSW2, TN11, TNG71, and TNG84 accumulated brown rice Pb exceeding the tolerable level of 0.2mgkg -1 . In contrast, the cultivars TNGS22, TK9, TK14, and TY3 accumulated much lower brown rice Pb (iron oxides deposited on the rhizosphere soil show stronger affinity to soil-available Pb than those on the root surface to form iron plaque. The relative tendency of Pb sequestration toward rhizosphere soil was negatively correlated with the Pb concentrations in brown rice. The iron oxides deposited on the rhizosphere soil but not on the root surface to form iron plaque dominate Pb sequestration in the rhizosphere. Therefore, the enhancement of iron oxide deposits on the rhizosphere soil could serve as a barrier preventing soil Pb on the root surface and result in reduced Pb accumulation in brown rice. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Educational Experiences in Oceanography through Hands-On Involvement with Surface Drifters: an Introduction to Ocean Currents, Engineering, Data Collection, and Computer Science

    Science.gov (United States)

    Anderson, T.

    2015-12-01

    The Northeast Fisheries Science Center's (NEFSC) Student Drifters Program is providing education opportunities for students of all ages. Using GPS-tracked ocean drifters, various educational institutions can provide students with hands-on experience in physical oceanography, engineering, and computer science. In building drifters many high school and undergraduate students may focus on drifter construction, sometimes designing their own drifter or attempting to improve current NEFSC models. While learning basic oceanography younger students can build drifters with the help of an educator and directions available on the studentdrifters.org website. Once drifters are deployed, often by a local mariner or oceanographic partner, drifter tracks can be visualised on maps provided at http://nefsc.noaa.gov/drifter. With the lesson plans available for those interested in computer science, students may download, process, and plot the drifter position data with basic Python code provided. Drifter tracks help students to visualize ocean currents, and also allow them to understand real particle tracking applications such as in search and rescue, oil spill dispersion, larval transport, and the movement of injured sea animals. Additionally, ocean circulation modelers can use student drifter paths to validate their models. The Student Drifters Program has worked with over 100 schools, several of them having deployed drifters on the West Coast. Funding for the program often comes from individual schools and small grants but in the future will preferably come from larger government grants. NSF, Sea-Grant, NOAA, and EPA are all possible sources of funding, especially with the support of multiple schools and large marine education associations. The Student Drifters Program is a unique resource for educators, students, and scientists alike.

  5. Realization of two light particle correlation experiments: behaviour to very low relative momenta (measurement with a magnetic spectrometer) and influence of the violence of reaction on the emission sources (measured by the neutron detector ORION); Mise en oeuvre de deux experiences de correlations de particules legeres: comportement a tres faibles impulsions relatives (mesure avec un spectrometre magnetique) et influence de la violence de reaction sur les sources d`emission (mesuree avec le detecteur de neutrons ORION)

    Energy Technology Data Exchange (ETDEWEB)

    Sezac, L. [Grenoble-1 Univ., 38 (France)

    1993-01-20

    The correlation measurements between light particles emitted during heavy ion collisions allow to estimate the time-space extension of the emitting sources. This report about the preliminaries of two correlation experiments is split into two parts. The first one describes a test experiment, performed to study the feasibility of a correlation experiment at very low relative momenta with the help of a magnetic spectrometer. The results will allow to determine the still unknown relative effects from the final state interaction and the combination of both Coulomb interaction and quantum statistics. A correlation study without experimental selection of the impact parameter gives unclear answers about the sizes and the temporal characteristics of the emitting systems. The second part analyses the sources of the alpha particles detected in the reaction chamber of the multidetector ORION used as a violence of the reaction filter. The results show that it is possible to consider as a good filter a fast information called `prompt peak` (correlated to the neutron multiplicity detected with ORION). Under such conditions a study of two particle correlations from equilibrated systems with a reasonable statistics becomes thinkable. The results obtained allow to characterize the emitting sources (speed, intensity, temperature) as a function of the violence of the reaction for the system {sup 208} Pb + {sup 93} Nb at 29 MeV/u. (author) 85 refs.

  6. Pre-licensed driving experience and car crash involvement during the learner and restricted, licence stages of graduated driver licensing: Findings from the New Zealand drivers study.

    Science.gov (United States)

    Begg, Dorothy J; Langley, John D; Brookland, Rebecca L; Ameratunga, Shanthi; Gulliver, Pauline

    2014-01-01

    The aim of this study was to determine whether pre-licence driving experiences, that is driving before beginning the licensing process, increased or decreased crash risk as a car driver, during the learner or the restricted licence stages of the graduated driver licensing system (GDLS). Study participants were 15-24 year old members of the New Zealand Drivers Study (NZDS) - a prospective cohort study of newly licensed car drivers. The interview stages of the NZDS are linked to, the three licensing stages of the GDLS: learner, restricted and full. Baseline demographic (age, ethnicity, residential location, deprivation), personality (impulsivity, sensation seeking, aggression) and, behavioural data, (including pre-licensed driving behaviour), were obtained at the learner licence interview. Data on distance driven and crashes that occurred at the learner licence and restricted licence stages, were reported at the restricted and full licence interviews, respectively. Crash data were also obtained from police traffic crash report files and this was combined with the self-reported crash data. The analysis of the learner licence stage crashes, when only supervised driving is allowed, was based on the participants who had passed the restricted licence test and undertaken the NZDS, restricted licence interview (n=2358). The analysis of the restricted licence stage crashes, when unsupervised driving is first allowed, was based on those who had passed the full licence test and completed the full licence interview (n=1428). After controlling for a range of demographic, personality, behavioural variables and distance driven, Poisson regression showed that the only pre-licence driving behaviour that showed a consistent relationship with subsequent crashes was on-road car driving which was associated with an increased risk of being the driver in a car crash during the learner licence period. This research showed that pre-licensed driving did not reduce crash risk among learner or

  7. Commitment of involved actors in the preparation of accidental and post-accident situations: European experiments; Engagement des parties prenantes a la preparation aux situations accidentelles et post-accidentelles: experiences Europeennes

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Th. [CEPN, 28 rue de la Redoute, 92260 Fontenay-aux-Roses (France)

    2010-07-01

    The author briefly describes some approaches developed within the EURANOS European research programme between 2004 and 2009 which aims at promoting the building up of a European network (NERIS) for the management of nuclear accidental and post-accident situations. Notably, he comments the experiment which took place in the Montbeliard district where two types of radiological events have been modelled and simulated: an accident in the Fessenheim nuclear power plant with two scenarios of release, and a transportation accident with a release of radioactive caesium 137. He also evokes the Norwegian experience and some other actions in Finland, Great-Britain, Spain and Slovakia where reflections on the management of accidental and post-accident situations or crisis exercises have been organized

  8. Tables of the 3-j, 6-j, Fsub(k)-, Asub(k)-, Rsub(k)-, and Asub(kk)-coefficients for angular correlation measurements involving half integer spins up to 15/2 and transitions up to L = 3

    International Nuclear Information System (INIS)

    Gueven, H.H.; Kardon, B.; Seyfarth, H.

    1975-07-01

    Theoretical directional correlation coefficiencts are given as 3-j, 6-j, Fsub(k), Asub(k), Rsub(k) and Asub(kk) coefficients for half integer spins up to 15/2 and for transitions up to L = 3. (WL) [de

  9. Microorganisms involved in MIC

    Energy Technology Data Exchange (ETDEWEB)

    Sorensen, K. [Danish Technological Institute (Denmark)

    2011-07-01

    Microbiologically influenced corrosion (MIC) is a widespread problem that is difficult to detect and assess because of its complex mechanism. This paper presents the involvement of microorganisms in MIC. Some of the mechanisms that cause MIC include hydrogen consumption, production of acids, anode-cathode formation and electron shuttling. A classic bio-corrosive microorganism in the oil and gas industry is sulphate-reducing prokaryotes (SRP). Methanogens also increase corrosion rates in metals. Some of the phylogenetic orders detected while studying SRP and methanogens are archaeoglobales, clostridiales, methanosarcinales and methanothermococcus. There were some implications, such as growth of SRP not being correlated with growth of methanogens; methanogens were included in MIC risk assessment. A few examples are used to display how microorganisms are involved in topside corrosion and microbial community in producing wells. From the study, it can be concluded that, MIC risk assessment includes system data and empirical knowledge of the distribution and number of microorganisms in the system.

  10. Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Qian-Jun; Zhang, Shui-Xing; Chen, Wen-Bo; Liang, Long; Zhou, Zheng-Gen; Liu, Zai-Yi; Zeng, Qiong-Xin; Liang, Chang-Hong [Guangdong General Hospital/Guangdong Academy of Medical Sciences, Department of Radiology, Guangzhou, Guangdong Province (China); Qiu, Qian-Hui [Guangdong General Hospital/Guangdong Academy of Medical Sciences, Department of Otolaryngology, Guangzhou, Guangdong Province (China)

    2014-12-15

    To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters. Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13 b-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (ER) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman's correlation coefficient. Intra- and interobserver reproducibility were excellent to relatively good (ICC = 0.887-0.997; narrow width of 95 % limits of agreement). The highest correlation was observed between f and EA (r = 0.633, P < 0.001), with a strong correlation between f and MSI (r = 0.598, P = 0.001). No correlation was observed between f and ER (r = -0.162; P = 0.421) or D* and DCE parameters (r = 0.125-0.307; P > 0.119). This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and f correlates significantly with EA and MSI. (orig.)

  11. 'We have to put up with it--don't we?' The experience of being the registered nurse on duty, managing a violent incident involving an elderly patient: a phenomenological study.

    Science.gov (United States)

    Chambers, N

    1998-02-01

    The incidence of violence directed towards nurses is well known. However, despite guidelines and training aimed at preventing or minimizing these incidents, recent reports indicate an increase in their occurrence. This phenomenological study investigated the experiences of five registered nurses who had to manage a violent incident involving an elderly patient. The purpose of this was to discover what these nurses 'know' about the structure of such an experience and, through the use of Colaizzi's method of data analysis, present this knowledge in the form of an exhaustive description of the experience. Taped interviews were used to collect the data. The analytical process revealed that the experience is structured around five themes: professional competence, nursing identity, powerlessness and oppression, loss (neglected and deserted) and strategies for survival. The discussion analyses these themes and the relationships between them, highlighting the issues of nurse autonomy and exercising accountability. The implications for nursing practice, education and research include recognition of nurses as a professional group to enable autonomous practice, the ways in which nurses' perceptions of nursing knowledge may affect their educative role and the need to extend this study further to provide answers to the questions raised therein.

  12. A primer of statistical methods for correlating parameters and properties of electrospun poly(l -lactide) scaffolds for tissue engineering-PART 1: Design of experiments

    KAUST Repository

    Seyedmahmoud, Rasoul; Rainer, Alberto; Mozetic, Pamela; Maria Giannitelli, Sara; Trombetta, Marcella; Traversa, Enrico; Licoccia, Silvia; Rinaldi, Antonio

    2014-01-01

    parameters (the Xs), considering the single effect as well as interactions between Xs. For the first time, the major role of the MW emerges clearly in controlling all scaffold properties. The correlation between mechanical and morphological properties is also

  13. Learning efficient correlated equilibria

    KAUST Repository

    Borowski, Holly P.; Marden, Jason R.; Shamma, Jeff S.

    2014-01-01

    The majority of distributed learning literature focuses on convergence to Nash equilibria. Correlated equilibria, on the other hand, can often characterize more efficient collective behavior than even the best Nash equilibrium. However, there are no existing distributed learning algorithms that converge to specific correlated equilibria. In this paper, we provide one such algorithm which guarantees that the agents' collective joint strategy will constitute an efficient correlated equilibrium with high probability. The key to attaining efficient correlated behavior through distributed learning involves incorporating a common random signal into the learning environment.

  14. Learning efficient correlated equilibria

    KAUST Repository

    Borowski, Holly P.

    2014-12-15

    The majority of distributed learning literature focuses on convergence to Nash equilibria. Correlated equilibria, on the other hand, can often characterize more efficient collective behavior than even the best Nash equilibrium. However, there are no existing distributed learning algorithms that converge to specific correlated equilibria. In this paper, we provide one such algorithm which guarantees that the agents\\' collective joint strategy will constitute an efficient correlated equilibrium with high probability. The key to attaining efficient correlated behavior through distributed learning involves incorporating a common random signal into the learning environment.

  15. An investigation of critical heat fluxes in vertical tubes internally cooled by Freon-12. Part I - Critical heat flux experiments with axially uniform and non-uniform heating and comparisons of data with selected correlations

    International Nuclear Information System (INIS)

    Green, W.J.; Stevens, J.R.

    1981-08-01

    Experiments have been performed using vertical heated tubes, cooled internally by Freon-12, to determine critical heat fluxes (CHFs) for both a uniformly heated section and an exit region with a separately controlled power supply. Heated lengths of the main separately were 2870 mm (8.48 and 16.76 mm tube bores) and 3700 mm (for 21.34 mm tube bore); heated length of the exit section was 230 mm. Coolant pressures, exit qualities and mass fluxes were in the range 0.9 to 1.3 MPa, 0.19 to 0.86, and 380 to 2800 kg m -2 s -1 , respectively. The data have been compared with published empirical correlations specifically formulated to predict CHFs in Freon-cooled, vertical tubes; relevant published CHF data have also been compared with these correlations. These comparisons show that, even over the ranges of conditions for which the correlations were developed, predicted values are only accurate to within +-20 per cent. Moreover, as mass fluxes increase above 3500 kg m -2 s -1 , the modified Groeneveld correlation becomes increasingly inadequate, and the Bertoletti and modified Bertoletti correlations under-predict CHF values by increasing amounts. At mass fluxes below 750 kg m -2 s -1 the Bertoletti correlations exhibit increasing inaccuracy with a decrease in mass flux. For non-uniform heating, the correlations are at variance with the experimental data

  16. Some simple demonstration experiments involving homopolar motors

    OpenAIRE

    Stewart, Seán M.

    2007-01-01

    The ready availability of very strong permanent magnets in the form of rare-earth magnetic alloys such as neodymium-iron-boron has lead to renewed interest in one of the oldest types of electric motors - the homopolar motor. The ease with which a demonstration homopolar motor can now be built and operated when neodymium magnets are used is quite remarkable. In this paper some simple homopolar motors employing neodymium magnets suitable for demonstrational purposes are described and discussed....

  17. Some simple demonstration experiments involving homopolar motors

    OpenAIRE

    Stewart,Seán M.

    2007-01-01

    The ready availability of very strong permanent magnets in the form of rare-earth magnetic alloys such as neodymium-iron-boron has lead to renewed interest in one of the oldest types of electric motors - the homopolar motor. The ease with which a demonstration homopolar motor can now be built and operated when neodymium magnets are used is quite remarkable. In this paper some simple homopolar motors employing neodymium magnets suitable for demonstrational purposes are described and discussed.

  18. Experiências infantis e risco de abuso físico: mecanismos envolvidos na repetição da violência Child's experiences and risk of physical abuse: mechanisms involved in repeating violence

    Directory of Open Access Journals (Sweden)

    Lilian Paula Degobbi Bérgamo

    2011-01-01

    Full Text Available Este estudo verificou a transmissão geracional do abuso físico, investigando variáveis relacionadas às práticas educativas e de cuidados recebidas na infância e a qualidade de relacionamento com os pais em dois grupos, um formado por cuidadores notificados aos Conselhos Tutelares (G1 e outro sem histórico de violência contra os filhos (G2. Um percentual significativamente maior de G1 avaliou ter sofrido punição física na infância de forma mais grave e mais freqüente que G2, caracterizando abuso físico e/ou psicológico. Ademais, os participantes do G1 avaliaram sua relação com os responsáveis e o ambiente familiar no qual foram criados de modo mais negativo que G2. Os resultados permitiram descrever alguns mecanismos envolvidos na transmissão geracional da violência, oferecendo pistas para a prevenção.This study verified the generational transmission of physical abuse examining variables related to educative and care practices received during childhood and the relationship with the parents. Two groups were formed, one of parents notified by Child Protective Service Agencies for maltreatment (G1 and the other with no violence background against their children (G2, both were compared afterwards. An expressive percentage of G1 participants reported have received more severe physical punishment in the childhood and even more frequent than G2, which characterized the presence of psychological or physical abuse. Furthermore, G1 participants evaluated the relation with their parents and the family environment in which they were raised in a more negative way than G2 participants. The results enabled the illustration of some mechanisms involved in the generational transmission of violence, outlining some ways to prevent the problem.

  19. MRI of the knee: how do field strength and radiologist's experience influence diagnostic accuracy and interobserver correlation in assessing chondral and meniscal lesions and the integrity of the anterior cruciate ligament?

    International Nuclear Information System (INIS)

    Krampla, W.; Roesel, M.; Svoboda, K.; Nachbagauer, A.; Gschwantler, M.; Hruby, W.

    2009-01-01

    Accuracy of MRI reports is taken for granted. In this paper the inter-observer reliability in the interpretation of meniscal lesions, degree of chondropathy, and integrity of the ACL was analyzed while taking the radiologist's experience and field strength into account. Fifty-two MRI studies of knees were interpreted by 11 radiologists independently. Twenty-two were acquired on 1.0-T, 20 on 1.5-T, and 10 on 3.0-T systems. Four of the radiologists had more than 5 years and seven had 3 to 5 years of experience in interpreting MRI studies. The findings were compared with the intra-operative findings. Inter-observer variance, specificity, and sensitivity were evaluated for each field strength. Inter-observer correlation ranged between 0.370 for cartilage lesions and 0.597 for meniscal tears. Correlation values did not increase with experience or field strength. The number of false reports was dependent on the observer, but not on field strength. The rate of false interpretations was significantly higher for most criteria in the less experienced group. In conclusion, inter-observer correlation was low, although the diagnostic criteria were defined. The use of the classification scheme should be standardized by uniform training. Radiologist experience seems to be more important than field strength. (orig.)

  20. Investigation of parity mixing in nuclear states by measurement of beta-gamma directional correlations at the transition 203Hg- 203Tl and a control experiment hereto

    International Nuclear Information System (INIS)

    Serentschy, G.

    1978-01-01

    Models of the Weak Interaction Hamiltonian predict a variety of parity-non-conserving (PNC) effects whose typical feature is odd transformation behavior under space reflection. The investigation of these effects is the task of the so-called parity experiments. Remeasurement of a PNC-effect at the 279 keV level in Tl-203 and the realization of a control experiment with the same apparatus to get information about possible systematic errors in it, are the subject of the submitted dissertation. Furthermore all relevant existing methods and some exciting trends in the field of PNC-experiments are extensively discussed with the aim of a better understanding of the present experimental situation, the prospects and especially the significance of this experiment at Tl-203. It could be demonstrated, that PNC-experiments on heavy nuclei (such as Tl-203) are less important now than they were five years ago, because of the insufficient understanding of the structure of heavy nuclei on the one hand, and the increasing importance (caused by technological improvements) of PNC-experiments at much better calculable systems, such as few nucleon systems and light atoms (muonic or electronic), on the other hand. The preliminary result of this control experiment is not clear enough for drawing final conclusions yet, particularly it is not possible, taking this preliminary result as a basis, to prove our apparatus either to be free of systematic errors or not. (author)

  1. [Correlation and concordance between the national test of medicine (ENAM) and the grade point average (GPA): analysis of the peruvian experience in the period 2007 - 2009].

    Science.gov (United States)

    Huamaní, Charles; Gutiérrez, César; Mezones-Holguín, Edward

    2011-03-01

    To evaluate the correlation and concordance between the 'Peruvian National Exam of Medicine' (ENAM) and the Mean Grade Point Average (GPA) in recently graduated medical students in the period 2007 to 2009. We carried out a secondary data analysis, using the records of the physicians applying to the Rural and Urban Marginal Service in Health of Peru (SERUMS) processes for the years 2008 to 2010. We extracted from these registers, the grades obtained in the ENAM and GPA. We performed a descriptive analysis using medians and 1st and 3rd quartiles (q1/q3); we calculated the correlation between both scores using the Spearman correlation coefficient, additionally, we conducted a lineal regression analysis, and the concordance was measured using the Bland and Altman coefficient. A total of 6 117 physicians were included, the overall median for the GPA was 13.4 (12.7/14.2) and for the ENAM was 11.6 (10.2/13.0).Of the total assessed, 36.8% failed the TEST. We observed an increase in annual median of ENAM scores, with the consequent decrease in the difference between both grades. The correlation between ENAM and PPU is direct and moderate (0.582), independent from the year, type of university management (Public or Private) and location. However, the concordance between both ratings is regular, with a global coefficient of 0.272 (CI 95%: 0.260 to 0.284). Independently of the year, location or type of university management, there is a moderate correlation between the ENAM and the PPU; however, there is only a regular concordance between both grades.

  2. [Father involvement in childbirth].

    Science.gov (United States)

    Villalón, H; Toro, R; Riesco, I; Pinto, M; Silva, C

    2014-10-01

    Recent initiatives have promoted the participation of fathers in the early care of their children. To assess the results of a program to encourage parental involvement in childbirth. Parents of healthy term newborns were randomly allocated to participate either in the birth experience or control. The protocol included: to dry the skin, umbilical cord cutting off, weight, height, and finally give him/her to the mother for the skin-to-skin contact. Heart rate (HR), respiratory (RR) and temperature were evaluated one hour later. In the first outpatient clinic assessment, mothers completed a questionnaire. 127 fathers participated either in the birth experience or control. 62 followed the protocol and 65 the control. Both newborn groups were comparable. Also were fathers in age, education and rurality; mothers in primiparity. Significant differences: night care (37/62, 10/65 59.6% vs 15.4%, pfathers at birth, even belonging to a discouraging socio cultural environment.

  3. Superadditive correlation

    International Nuclear Information System (INIS)

    Giraud, B.G.; Heumann, J.M.; Lapedes, A.S.

    1999-01-01

    The fact that correlation does not imply causation is well known. Correlation between variables at two sites does not imply that the two sites directly interact, because, e.g., correlation between distant sites may be induced by chaining of correlation between a set of intervening, directly interacting sites. Such 'noncausal correlation' is well understood in statistical physics: an example is long-range order in spin systems, where spins which have only short-range direct interactions, e.g., the Ising model, display correlation at a distance. It is less well recognized that such long-range 'noncausal' correlations can in fact be stronger than the magnitude of any causal correlation induced by direct interactions. We call this phenomenon superadditive correlation (SAC). We demonstrate this counterintuitive phenomenon by explicit examples in (i) a model spin system and (ii) a model continuous variable system, where both models are such that two variables have multiple intervening pathways of indirect interaction. We apply the technique known as decimation to explain SAC as an additive, constructive interference phenomenon between the multiple pathways of indirect interaction. We also explain the effect using a definition of the collective mode describing the intervening spin variables. Finally, we show that the SAC effect is mirrored in information theory, and is true for mutual information measures in addition to correlation measures. Generic complex systems typically exhibit multiple pathways of indirect interaction, making SAC a potentially widespread phenomenon. This affects, e.g., attempts to deduce interactions by examination of correlations, as well as, e.g., hierarchical approximation methods for multivariate probability distributions, which introduce parameters based on successive orders of correlation. copyright 1999 The American Physical Society

  4. Finite element formulation for a digital image correlation method

    International Nuclear Information System (INIS)

    Sun Yaofeng; Pang, John H. L.; Wong, Chee Khuen; Su Fei

    2005-01-01

    A finite element formulation for a digital image correlation method is presented that will determine directly the complete, two-dimensional displacement field during the image correlation process on digital images. The entire interested image area is discretized into finite elements that are involved in the common image correlation process by use of our algorithms. This image correlation method with finite element formulation has an advantage over subset-based image correlation methods because it satisfies the requirements of displacement continuity and derivative continuity among elements on images. Numerical studies and a real experiment are used to verify the proposed formulation. Results have shown that the image correlation with the finite element formulation is computationally efficient, accurate, and robust

  5. Deuterium incorporation experiments from (3R)- and (3S)-[3-2H]leucine into characteristic isoprenoidal lipid-core of halophilic archaea suggests the involvement of isovaleryl-CoA dehydrogenase.

    Science.gov (United States)

    Yamauchi, Noriaki; Tanoue, Ryo

    2017-11-01

    The stereochemical reaction course for the two C-3 hydrogens of leucine to produce a characteristic isoprenoidal lipid in halophilic archaea was observed using incubation experiments with whole cell Halobacterium salinarum. Deuterium-labeled (3R)- and (3S)-[3- 2 H]leucine were freshly prepared as substrates from 2,3-epoxy-4-methyl-1-pentanol. Incorporation of deuterium from (3S)-[3- 2 H]leucine and loss of deuterium from (3R)-[3- 2 H]leucine in the lipid-core of H. salinarum was observed. Taken together with the results of our previous report, involving the incubation of chiral-labeled [5- 2 H]leucine, these results strongly suggested an involvement of isovaleryl-CoA dehydrogenase in leucine conversion to isoprenoid lipid in halophilic archaea. The stereochemical course of the reaction (anti-elimination) might have been the same as that previously reported for mammalian enzyme reactions. Thus, these results suggested that branched amino acids were metabolized to mevalonate in archaea in a manner similar to other organisms.

  6. H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex

    Directory of Open Access Journals (Sweden)

    Gabriela Vierci

    2016-01-01

    Full Text Available Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4 and its modulation by visual experience in the mouse visual cortex (VC during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment. We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC.

  7. Triple resonance experiments for the simultaneous correlation of H6/H5 and exchangeable protons of pyrimidine nucleotides in 13C,15N-labeled RNA applicable to larger RNA molecules

    International Nuclear Information System (INIS)

    Woehnert, Jens; Goerlach, Matthias; Schwalbe, Harald

    2003-01-01

    Triple-resonance two-dimensional H6/H5(C4N)H and C6/C5(C4N)H experiments are described that provide through-bond H6/H5 or C6/C5 to imino/amino correlations in pyrimidine bases in 13 C, 15 N-labeled RNA. The experiments simultaneously transfer H6/H5 magnetization by an INEPT step to the C6/C5 nuclei and by homonuclear CC- and heteronuclear CN-TOCSY steps via the intervening C4 nucleus to the N3/N4 nuclei and then by a reverse INEPT step to the imino/amino hydrogens. The sensitivity of these experiments is high as demonstrated using a 30-nucleotide pyrimidine rich RNA at a concentration of 0.9 mM at temperatures of 10 deg. C and 25 deg. C. This indicates the general applicability of the experiments and the possibility to obtain correlations for imino resonances in non-canonical regions of the target RNA

  8. Correlation between histopathological and endoscopic findings of non-malignant gastrointestinal lesions: an experience of a tertiary care teaching hospital from Northern India

    Directory of Open Access Journals (Sweden)

    Manpreet Kaur

    2018-04-01

    Full Text Available Background: Gastrointestinal tract endoscopy along with biopsy is an established procedure for investigating a wide range of gastrointestinal conditions especially inflammatory and malignant diseases. The aim was to study and categorizing the morphological lesions of non-malignant origin at various sites of gastrointestinal tract and to compare with its endoscopic findings.Materials and Methods: This study was conducted on 280 benign GI biopsies received in the Department of Pathology of Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.Results: Maximum cases (39% were observed in the age group of 41-60 years. Male patients outnumbered the females (male to female ratio was 1.4:1. There were total 33 esophageal biopsies amongst which the most common lesion was non-specific esophagitis with least common being Barrett’s esophagus. Correlating the results of endoscopic and histopathological features of acute and chronic gastritis a positive predictive value of 80% with sensitivity of 44.4% was seen. Total 83 duodenal biopsies were analyzed with non-specific duodenitis being the most commonly diagnosed lesion followed by celiac disease. Correlation of endoscopic and histopathological findings in celiac disease revealed a sensitivity of 50% and positive predictive value of 42.86%. In both sigmoid colon and rectum, non-specific colitis was the commonest diagnosis followed by ulcerative colitis. Endoscopic findings were correlated with the histopathological features in ulcerative colitis, revealing a sensitivity of 57.14% along with the positive predictive value of 80%.  Conclusion: Histopathology remains the gold standard for diagnosing a case along with endoscopic findings and endoscopic findings alone cannot make the final diagnosis.

  9. Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences

    International Nuclear Information System (INIS)

    Pospisil, Petr; Kazda, Tomas; Bulik, Martin; Dobiaskova, Marie; Burkon, Petr; Hynkova, Ludmila; Slampa, Pavel; Jancalek, Radim

    2015-01-01

    The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by 1 H-MR spectroscopy focused on the hippocampus. Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily. Pre-radiotherapy 1 H-MR spectroscopy focused on the h-tNAA concentration and memory testing was performed. Memory was evaluated by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R). Total recall, recognition and delayed recall were reported. The both investigation procedures were repeated 4 months after WBRT and the h-tNAA and memory changes were correlated. Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4 after WBRT, respectively. In the memory tests a significant decrease was observed in AVLT total-recall, BVMT-R total-recall and BVMT-R delayed-recall. Weak to moderate correlations were observed between left h-tNAA and AVLT recognition and all BVMT-R subtests and between the right h-tNAA and AVLT total-recall. A significant decrease in h-tNAA after WBRT was proven by 1 H-MR spectroscopy as a feasible method for the in vivo investigation of radiation injury. Continuing patient recruitment focusing on other cognitive tests and metabolites is needed

  10. Correlation between dental caries experience and mutans streptococci counts using saliva and plaque as microbial risk indicators in 3-8 year old children. A cross Sectional study.

    Science.gov (United States)

    Nanda, Jasmine; Sachdev, Vinod; Sandhu, Meera; Deep-Singh-Nanda, Kanwar

    2015-02-01

    Determination of the relative amounts of mutans streptococcus in both saliva and plaque and to study its correlation with dental caries in children. The study comprised of 60 children aged 3-8 years divided into 2 groups (30 children in each): Group A- Children with more than 4 carious teeth and Group B- Children without caries. Saliva and plaque was collected from children of both the groups with the help of Dentocult SM strip test kit (Orion Diagnostic). Following incubation, mutans streptococcus scores (from 0 to 3) in each individual was evaluated and compared between both the groups. On comparing the two groups, mean ± SD of saliva score and plaque score was 2.40 ± 0.675 and 2.40 ± 0.621 respectively in group A, whereas it was 0.60 ± 0.498 and 0.83 ± 0.531 in children of group B showing a significant correlation (p = Key words:Mutans streptococci, dentocult, dental caries.

  11. Coronary CT angiography-derived fractional flow reserve correlated with invasive fractional flow reserve measurements - initial experience with a novel physician-driven algorithm

    International Nuclear Information System (INIS)

    Baumann, Stefan; Wang, Rui; Schoepf, U.J.; Steinberg, Daniel H.; Spearman, James V.; Bayer, Richard R.; Hamm, Christian W.; Renker, Matthias

    2015-01-01

    The present study aimed to determine the feasibility of a novel fractional flow reserve (FFR) algorithm based on coronary CT angiography (cCTA) that permits point-of-care assessment, without data transfer to core laboratories, for the evaluation of potentially ischemia-causing stenoses. To obtain CT-based FFR, anatomical coronary information and ventricular mass extracted from cCTA datasets were integrated with haemodynamic parameters. CT-based FFR was assessed for 36 coronary artery stenoses in 28 patients in a blinded fashion and compared to catheter-based FFR. Haemodynamically relevant stenoses were defined by an invasive FFR ≤0.80. Time was measured for the processing of each cCTA dataset and CT-based FFR computation. Assessment of cCTA image quality was performed using a 5-point scale. Mean total time for CT-based FFR determination was 51.9 ± 9.0 min. Per-vessel analysis for the identification of lesion-specific myocardial ischemia demonstrated good correlation (Pearson's product-moment r = 0.74, p < 0.0001) between the prototype CT-based FFR algorithm and invasive FFR. Subjective image quality analysis resulted in a median score of 4 (interquartile ranges, 3-4). Our initial data suggest that the CT-based FFR method for the detection of haemodynamically significant stenoses evaluated in the selected population correlates well with invasive FFR and renders time-efficient point-of-care assessment possible. (orig.)

  12. Prevalence and Correlates of Problematic Internet Experiences and Computer-Using Time: A Two-Year Longitudinal Study in Korean School Children

    OpenAIRE

    Yang, Su-Jin; Stewart, Robert; Lee, Ju-Yeon; Kim, Jae-Min; Kim, Sung-Wan; Shin, Il-Seon; Yoon, Jin-Sang

    2014-01-01

    Objective To measure the prevalence of and factors associated with online inappropriate sexual exposure, cyber-bullying victimisation, and computer-using time in early adolescence. Methods A two-year, prospective school survey was performed with 1,173 children aged 13 at baseline. Data collected included demographic factors, bullying experience, depression, anxiety, coping strategies, self-esteem, psychopathology, attention-deficit hyperactivity disorder symptoms, and school performance. Thes...

  13. Prevalence and correlates of problematic internet experiences and computer-using time: a two-year longitudinal study in korean school children.

    Science.gov (United States)

    Yang, Su-Jin; Stewart, Robert; Lee, Ju-Yeon; Kim, Jae-Min; Kim, Sung-Wan; Shin, Il-Seon; Yoon, Jin-Sang

    2014-01-01

    To measure the prevalence of and factors associated with online inappropriate sexual exposure, cyber-bullying victimisation, and computer-using time in early adolescence. A two-year, prospective school survey was performed with 1,173 children aged 13 at baseline. Data collected included demographic factors, bullying experience, depression, anxiety, coping strategies, self-esteem, psychopathology, attention-deficit hyperactivity disorder symptoms, and school performance. These factors were investigated in relation to problematic Internet experiences and computer-using time at age 15. The prevalence of online inappropriate sexual exposure, cyber-bullying victimisation, academic-purpose computer overuse, and game-purpose computer overuse was 31.6%, 19.2%, 8.5%, and 21.8%, respectively, at age 15. Having older siblings, more weekly pocket money, depressive symptoms, anxiety symptoms, and passive coping strategy were associated with reported online sexual harassment. Male gender, depressive symptoms, and anxiety symptoms were associated with reported cyber-bullying victimisation. Female gender was associated with academic-purpose computer overuse, while male gender, lower academic level, increased height, and having older siblings were associated with game-purpose computer-overuse. Different environmental and psychological factors predicted different aspects of problematic Internet experiences and computer-using time. This knowledge is important for framing public health interventions to educate adolescents about, and prevent, internet-derived problems.

  14. Quantitative correlations between collision induced dissociation mass spectrometry coupled with electrospray ionization or atmospheric pressure chemical ionization mass spectrometry - Experiment and theory

    Science.gov (United States)

    Ivanova, Bojidarka; Spiteller, Michael

    2018-04-01

    The problematic that we consider in this paper treats the quantitative correlation model equations between experimental kinetic and thermodynamic parameters of coupled electrospray ionization (ESI) mass spectrometry (MS) or atmospheric pressure chemical ionization (APCI) mass spectrometry with collision induced dissociation mass spectrometry, accounting for the fact that the physical phenomena and mechanisms of ESI- and APCI-ion formation are completely different. There are described forty two fragment reactions of three analytes under independent ESI- and APCI-measurements. The developed new quantitative models allow us to study correlatively the reaction kinetics and thermodynamics using the methods of mass spectrometry, which complementary application with the methods of the quantum chemistry provide 3D structural information of the analytes. Both static and dynamic quantum chemical computations are carried out. The object of analyses are [2,3-dimethyl-4-(4-methyl-benzoyl)-2,3-di-p-tolyl-cyclobutyl]-p-tolyl-methanone (1) and the polycyclic aromatic hydrocarbons derivatives of dibenzoperylen (2) and tetrabenzo [a,c,fg,op]naphthacene (3), respectively. As far as (1) is known to be a product of [2π+2π] cycloaddition reactions of chalcone (1,3-di-p-tolyl-propenone), however producing cyclic derivatives with different stereo selectivity, so that the study provide crucial data about the capability of mass spectrometry to provide determine the stereo selectivity of the analytes. This work also first provides quantitative treatment of the relations '3D molecular/electronic structures'-'quantum chemical diffusion coefficient'-'mass spectrometric diffusion coefficient', thus extending the capability of the mass spectrometry for determination of the exact 3D structure of the analytes using independent measurements and computations of the diffusion coefficients. The determination of the experimental diffusion parameters is carried out within the 'current monitoring method

  15. Entropic Nonsignaling Correlations.

    Science.gov (United States)

    Chaves, Rafael; Budroni, Costantino

    2016-06-17

    We introduce the concept of entropic nonsignaling correlations, i.e., entropies arising from probabilistic theories that are compatible with the fact that we cannot transmit information instantaneously. We characterize and show the relevance of these entropic correlations in a variety of different scenarios, ranging from typical Bell experiments to more refined descriptions such as bilocality and information causality. In particular, we apply the framework to derive the first entropic inequality testing genuine tripartite nonlocality in quantum systems of arbitrary dimension and also prove the first known monogamy relation for entropic Bell inequalities. Further, within the context of complex Bell networks, we show that entropic nonlocal correlations can be activated.

  16. Study of the correlation of gamma-ray families with the EAS by the Monte-Carlo simulation and a suggested future experiment

    International Nuclear Information System (INIS)

    Kasahara, K.; Torii, S.; Yuda, T.

    1981-01-01

    To examine information which may be obtained by the simultaneous observation of gamma-ray families and accompanying air showers, a Monte-Carlo simulation is carried out under various assumptions for primary cosmic rays and nuclear interactions. It is shown that only proton primary can produce those families that have energy greater than ΣEsub(γ) approximately=100 TeV with air shower size less than 10 5 ; other heavy primaries such as alpha, carbon etc always generate larger sizes than 10 5 for families ΣEsub(γ)>=100 TeV. Therefore we will be able to select families generated by proton primaries and discuss the character of nuclear interaction at very high energies without suffering from the problem of imitations of various new characters (large Pt, large multiplicity etc) by heavy primaries. Moreover, it is shown that the chemical composition of the primaries at >=10 15 eV region is possibly studied through ΣEsub(γ)-size correlation

  17. Correlation of cytological report obtained on FNAB with the sonographic features of thyroid nodular disease, experience for 4 months, Mexico Hospital

    International Nuclear Information System (INIS)

    Aragon Arrieta, Nazira

    2007-01-01

    The introduction in the market for ultrasound equipment with high resolution has opened the eyes of the radiologist and has made multiple pathologies that previously only were described by the pathologist, they are being recognized when performing a sonographic rating. The isotopic test has been the most used to assess the thyroid gland for many years. Other techniques are disposed at present for the evaluation of the same; ultrasound has been one of the most popular because it provides information of glandular pathology, determines behavior diagnosis, therapeutic or both. Besides, the low cost of doing the studies is another important factor to add. The realization of fine-needle biopsy of the thyroid gland is safe, inexpensive and minimally invasive; factors that influence plays an important role in the management of nodular thyroid disease. A correlation is established between sonographic findings and cytological reports obtained by FNAB, for 4 months (february to may 2006), in the population of Hospital Mexico, in order to set parameters that fit the environmental conditions. An observational study, retrospective and cross was performed. (author) [es

  18. Mockup experiments to investigate the leak rate correlation between mercury and helium for the mercury target system of J-PARC

    International Nuclear Information System (INIS)

    Haga, Katsuhiro; Naoe, Takashi; Kogawa, Hiroyuki; Wakui, Takashi; Futakawa, Masatoshi

    2009-01-01

    Checking the seal performance of the mercury piping network is very important for the mercury target system operation of J-PARC, and the test method for leaks using the pressure change measurement is preferable for this purpose because it can be carried out easily and precisely by measuring the pressure change, and it is free from the risk of mercury contamination. The piping network is pressurized by helium gas. Thus, the correlation between the helium leak rate and mercury leak flow rate was investigated experimentally by carrying out leak tests for helium and mercury with an identical mockup flange model. The results showed that the mercury leak flow rates of the experimental data were lower than those of the estimated value by 64% on average. It was also found that the threshold of the helium leak rate at which good seal performance for mercury can be obtained exists between 2.18 x 10 -4 and 1.01 x 10 -2 Pa.m 3 /s. This fact confirmed the sufficient safety margin of the mercury target system against the mercury leak, where 1 x 10 -6 Pa.m 3 /s was adopted as the seal performance criterion. (author)

  19. Forum on Stakeholder Confidence: A Platform to build and share Knowledge about Stakeholder Confidence in Radioactive Waste Management. Reflections on Stakeholder Involvement. How do we ensure engagement for a project running over decades - Case study Sweden. Case Study Switzerland: stakeholder involvement in the Swiss site selection procedure; View of the Implementer on the Swiss Site Selection Procedure. Stakeholder Engagement on Radioactive Waste: Australia's Experience

    International Nuclear Information System (INIS)

    Kuenzi, Pascale Jana; Shaver, Kathryn; Gerhardsson, Ansi; Toernqvist, Johanna Yngve; Bjoerklund, Sara

    2017-01-01

    social media to enhance stakeholder involvement included: creating polls to evaluate feedback and establishing more concrete metrics on public support, connecting with youth through popular applications such as Facebook and Twitter, establishing more open public dialogue, and building trust by providing a more accessible form of communication to enhance conversation. Another key message highlighted during the presentations focused on the information void for the public and key stakeholders regarding the subject of radioactive waste management. Ms Smith's presentation on Australia's experience with stakeholder engagement of radioactive waste highlighted the importance of not only providing the public with information, but also engaging the public on the subject matter in order to bridge an existing gap between intolerance and tolerance regarding radioactive waste management. One aspect that was evident in all of the presentations on radioactive waste management was an acknowledgement that the process of implementation has taken much longer than originally planned, and that it is challenging to gain trust and support from the local communities where deep geological repositories are being sited or built. All of the speakers recognised a similar dilemma regarding the acknowledgement of both technical and social components of radioactive waste management, both of which are necessary and should be established at the same time to ensure no void in decision making and realisation. Successful decision making is open, transparent and broadly participatory

  20. Correlation of needle core biopsy with excision histology in screen-detected B3 lesions: the Merrion Breast Screening Unit experience.

    LENUS (Irish Health Repository)

    Hayes, B D

    2012-02-01

    AIMS: Needle core biopsy (NCB) is a widely-used technique for non-operative evaluation of screen-detected breast lesions. Although most NCBs are B2 (benign) or B5 (malignant), some fall into the B3 category of "uncertain malignant potential". This study aims to categorise the lesions prompting a B3 NCB in the Merrion Breast Screening Unit, and establish the incidence of malignancy on subsequent excision biopsy. METHODS: Patients attending the Merrion Breast Screening Unit in Dublin between 2000 and 2008 who had a B3 NCB were identified. The NCB pathology reports were reviewed and the diagnosis correlated with excision histology; the latter was classified as benign, atypical or malignant. Lesion-specific positive predictive values (PPVs) for malignancy were derived. RESULTS: 141 patients with a B3 NCB were identified. The most frequent lesions on NCB were radial scar (RS; n = 57), atypical intraductal epithelial proliferation (AIDEP; n = 25) and papillary lesion (n = 24). The final diagnosis was malignant in 22 patients (16%), atypical in 40 (28%) and benign in 79 (56%). Two of the patients with a malignant diagnosis had invasive carcinoma. The lesion-specific PPVs were: lobular neoplasia 50%, AIDEP 32%, columnar cell lesion with atypia 12.5%, RS 12.3%, papillary lesion 8.3%, suspected phyllodes tumour 7.7%, and spindle cell lesion 0%. Atypia on RS NCB predicted an atypical or malignant excision diagnosis, but atypia on papillary lesion NCB did not. CONCLUSIONS: One-sixth of B3 NCBs in this series proved to be malignant on excision. The PPV for malignancy varied according to lesion type.

  1. Correlation of HER2 overexpression with gene amplification and its relation to chromosome 17 aneuploidy: a 5-year experience with invasive ductal and lobular carcinomas.

    Science.gov (United States)

    Nassar, Aziza; Khoor, Andras; Radhakrishnan, Reshmitha; Radhakrishnan, Anu; Cohen, Cynthia

    2014-01-01

    The HER2 oncogene shows expression or amplification, or both, in approximately 15% to 20% of breast cancers and has been associated with poor prognosis and a response to trastuzumab therapy. HER2 gene status determines the eligibility of breast cancer patients for trastuzumab therapy and a large fraction (41-56%) of these patients respond to targeted therapy. Several studies have related the increased expression of HER2 to an increased copy number of chromosome 17, rather than amplification of the HER2 gene. We compared the results of immunohistochemistry and fluorescence in situ hybridization in both invasive ductal and invasive lobular carcinomas, to determine the frequency of chromosome 17 aneuploidy associated with discordant results. In total, 390 invasive ductal carcinomas and 180 invasive lobular carcinomas diagnosed from January 2000 to December 2005 were included in the study only if results were available for immunohistochemistry (HercepTest; DAKO, Carpinteria, California) and fluorescence in situ hybridization (PathVysion HER2 DNA Probe Kit; Abbott Laboratories, Des Plaines, Illinois). Tumors classified as invasive ductal carcinomas were graded according to the Bloom-Richardson grading system. Correlation between the results of immunohistochemistry and fluorescence in situ hybridization was performed for all categories. Among invasive ductal carcinomas, 29% (115/390) showed chromosome 17 aneuploidy, mostly associated with grade 3/HER2 2+ (45%) or grade 2/HER2 3+ (55%) that were not amplified. Also, 34% (12/35) of invasive lobular carcinomas showed chromosome 17 aneuploidy; approximately one-third of these cases were HER2 2+ (33%) and HER2 3+ (37%) that were not amplified. Discordance between the results of immunohistochemistry and fluorescence in situ hybridization in both ductal and lobular carcinomas is largely associated with chromosome 17 aneuploidy.

  2. Correlations among self-esteem, aggression, adverse childhood experiences and depression in inmates of a female juvenile correctional facility in Japan.

    Science.gov (United States)

    Matsuura, Naomi; Hashimoto, Toshiaki; Toichi, Motomi

    2009-08-01

    The purpose of this study was to examine the following hypothesis: (i) Self-esteem and aggressiveness, adverse childhood experiences (ACE), and a depressive tendency interact with each other. (ii) The subjects show a strong depressive tendency, and each of the other factors exerts a main effect on, and interacts with, the depressive tendency. The subjects were 91 juveniles (all female) admitted to a female juvenile correctional facility between November 2005 and December 2006. They were aged 15-19 years, with a mean age of 17.0 (SD = 1.18) years. Self-esteem scale, aggression scale, ACE questionnaire, and depression scale were conducted. Significant main effects (R(2) = 0.50, P depression score were observed in self-esteem (beta = -0.41, P Self-esteem, aggression, ACE, and depression were found to be interrelated. Low self-esteem was also shown to exert marked effects on various factors. About half of the inmates of the facility were depressed, and the main effects of self-esteem, aggression, and the ACE score were shown to influence the depression score.

  3. CENTRAL AMYGDALOID INVOLVEMENT IN NEUROENDOCRINE CORRELATES OF CONDITIONED STRESS RESPONSES

    NARCIS (Netherlands)

    ROOZENDAAL, B; KOOLHAAS, JM; BOHUS, B

    The purpose of this study was to examine the effects of bilateral electrolytic lesions of the central nucleus of the amygdala (CEA) in comparison with sham lesions on neuroendocrine responses during conditioned emotional stress in male Wistar rats. Lesions in the CEA, made either before or after the

  4. Spin correlations in decay chains involving W bosons TH1"-->

    Science.gov (United States)

    Smillie, J. M.

    2007-08-01

    We study the extent to which spin assignments of new particles produced at the LHC can be deduced in the decay of a scalar or fermion C into a new stable (or quasi-stable) particle A through the chain C→B±q, B±→AW±, W±→ℓ±νℓ where ℓ=e,μ. All possible spin assignments of the particles A and B are considered. Explicit invariant mass distributions of the quark and lepton are given for each set of spins, valid for all masses. We also construct the asymmetry between the chains with a W- and those with a W+. The Kullback Leibler distance between the distributions is then calculated to give a quantitative measure of our ability to distinguish the different spin assignments.

  5. Diffusive transport in a one dimensional disordered potential involving correlations

    International Nuclear Information System (INIS)

    Monthus, C.; Paris-6 Univ., 75

    1995-03-01

    Transport properties of one dimensional Brownian diffusion under the influence of a quenched random force, distributed as a two-level Poisson process is discussed. Large time scaling laws of the position of the Brownian particle, and the probability distribution of the stationary flux going through a sample between two prescribed concentrations are studied. (author) 14 refs.; 3 figs

  6. Neudesin is involved in anxiety behavior: structural and neurochemical correlates

    Directory of Open Access Journals (Sweden)

    Ashley eNovais

    2013-09-01

    Full Text Available Neudesin (also known as neuron derived neurotrophic factor, Nenf is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional and cognitive dimensions of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze, light/dark box and novelty suppressed feeding tests, but not in the acoustic startle test. This anxious phenotype is associated with reduced dopaminergic input and impoverished dendritic arborizations in the dentate gyrus granule neurons of the ventral hippocampus. Interestingly, shorter dendrites are also observed in the bed nucleus of the stria terminalis (BNST of neudesin-null mice. These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry.

  7. Spin correlations in decay chains involving W bosons

    International Nuclear Information System (INIS)

    Smillie, J.M.

    2007-01-01

    We study the extent to which spin assignments of new particles produced at the LHC can be deduced in the decay of a scalar or fermion C into a new stable (or quasi-stable) particle A through the chain C→B ± q, B ± →AW ± , W ± →l ± ν l where l=e,μ. All possible spin assignments of the particles A and B are considered. Explicit invariant mass distributions of the quark and lepton are given for each set of spins, valid for all masses. We also construct the asymmetry between the chains with a W - and those with a W + . The Kullback-Leibler distance between the distributions is then calculated to give a quantitative measure of our ability to distinguish the different spin assignments. (orig.)

  8. Correlation Between the Severity of Cetuximab-Induced Skin Rash and Clinical Outcome for Head and Neck Cancer Patients: The RTOG Experience

    Energy Technology Data Exchange (ETDEWEB)

    Bar-Ad, Voichita, E-mail: voichita.bar-ad@jefferson.edu [Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Zhang, Qiang [NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania (United States); Harari, Paul M. [University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin (United States); Axelrod, Rita [Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Rosenthal, David I. [University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Trotti, Andy [H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida (United States); Jones, Christopher U. [Radiological Associates of Sacramento, Sacramento, California (United States); Garden, Adam S. [University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Song, Guobin [Virginia Mason Medical Center, Seattle, Washington (United States); Foote, Robert L. [Mayo Clinic, Rochester, Minnesota (United States); Raben, David [University of Colorado Comprehensive Cancer Center, Denver, Colorado (United States); Shenouda, George [McGill University, Montreal, Quebec (Canada); Spencer, Sharon A. [University of Alabama at Birmingham, Birmingham, Alabama (United States); Harris, Jonathan [NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania (United States); Le, Quynh-Thu [Stanford University Medical Center, Stanford, California (United States)

    2016-08-01

    Purpose: To evaluate the severity of cetuximab-induced skin rash and its correlation with clinical outcome and late skin toxicity in patients with head and neck squamous cell carcinoma treated with chemoradiation therapy and cetuximab. Methods and Materials: Analysis included patients who received loading dose and ≥1 cetuximab dose concurrent with definitive chemoradiation therapy (70 Gy + cisplatin) or postoperative chemoradiation therapy (60-66 Gy + docetaxel or cisplatin). Results: Six hundred two patients were analyzed; 383 (63.6%) developed grade 2 to 4 cetuximab rash. Patients manifesting grade 2 to 4 rash had younger age (P<.001), fewer pack-years smoking history (P<.001), were more likely to be males (P=.04), and had p16-negative (P=.04) oropharyngeal tumors (P=.003). In univariate analysis, grade 2 to 4 rash was associated with better overall survival (hazard ratio [HR] 0.58, P<.001) and progression-free survival (HR 0.75, P=.02), and reduced distant metastasis rate (HR 0.61, P=.03), but not local-regional failure (HR 0.79, P=.16) relative to grade 0 to 1 rash. In multivariable analysis, HRs for overall survival, progression-free survival, distant metastasis, and local-regional failure were, respectively, 0.68 (P=.008), 0.85 (P=.21), 0.64 (P=.06), and 0.89 (P=.48). Grade ≥2 rash was associated with improved survival in p16-negative patients (HR 0.28 [95% confidence interval 0.11-0.74]) but not in p16-positive patients (HR 1.10 [0.42-2.89]) (P=.05 for interaction). Twenty-five percent of patients with grade 2 to 4 acute in-field radiation dermatitis experienced grade 2 to 4 late skin fibrosis, versus 14% of patients with grade 0 to 1 acute in-field radiation dermatitis (P=.002). Conclusion: Grade 2 to 4 cetuximab rash was associated with better survival, possibly due to reduction of distant metastasis. This observation was noted mainly in p16-negative patients. Grade 2 to 4 acute in-field radiation dermatitis was associated with higher rate of

  9. Correlation between the severity of cetuximab-induced skin rash and clinical outcome for head and neck cancer patients: The XXXX experience

    Science.gov (United States)

    Bar-Ad, Voichita; Zhang, Qiang (Ed); Harari, Paul M.; Axelrod, Rita; Rosenthal, David I.; Trotti, Andy; Jones, Christopher U.; Garden, Adam S.; Song, Guobin; Foote, Robert L.; Raben, David; Shenouda, George; Spencer, Sharon A.; Harris, Jonathan; Le, Quynh-Thu

    2016-01-01

    Purpose The purpose of the present study was to evaluate severity of cetuximab-induced skin rash and its correlation with clinical outcome and late skin toxicity in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy and cetuximab. Materials & Methods Analysis included patients who received loading dose and ≥ 1cetuximab dose concurrent with definitive chemoradiotherapy (70Gy + cisplatin) or postoperative chemoradiotherapy (60–66Gy + docetaxel or cisplatin). Results Six hundred two patients were analyzed; 383 (63.6%) developed Grade 2–4 cetuximab rash. Patients manifesting Grade 2–4 rash had younger age (p<0.001), fewer pack-years smoking history (p<0.001), were more likely to be males (p=0.04), and had p16-negative (p=0.04) oropharyngeal tumors (p=0.003). In univariate analysis, Grade 2–4 rash was associated with better overall survival (OS) (hazard ratio [HR] 0.58, p<0.001) and progression-free survival (PFS) (HR 0.75, p=0.02), and reduced distant metastasis (DM) rate (HR 0.61, p=0.03), but not local-regional failure (LRF) (HR 0.79, p=0.16) relative to Grade 0–1 rash. In multivariable analysis, HRs for OS, PFS, DM, and LRF were 0.68 (p=0.008), 0.85 (p=0.21), 0.64 (p=0.06), and 0.89 (p=0.48). Grade ≥2 rash was associated with improved survival in p16 negative patients (HR 0.28 (0.11–0.74)) but not in p16 positive patients (HR 1.10 (0.42–2.89)) (p=0.05 for interaction). Twenty-five percent of patients with Grade 2–4 acute in-field radiation dermatitis experienced Grade 2–4 late skin fibrosis vs. 14% of patients with Grade 0–1 acute in-field radiation dermatitis (p=0.002). Conclusion Grade 2–4 cetuximab rash was associated with better survival possibly due to reduction of distant metastasis. This observation was noted mainly in p16 negative patients. Grade 2–4 acute in-field radiation dermatitis was associated with higher rate of late Grade 2–4 skin fibrosis. PMID:27212198

  10. Variable angle correlation spectroscopy

    International Nuclear Information System (INIS)

    Lee, Y.K.; Lawrence Berkeley Lab., CA

    1994-05-01

    In this dissertation, a novel nuclear magnetic resonance (NMR) technique, variable angle correlation spectroscopy (VACSY) is described and demonstrated with 13 C nuclei in rapidly rotating samples. These experiments focus on one of the basic problems in solid state NMR: how to extract the wealth of information contained in the anisotropic component of the NMR signal while still maintaining spectral resolution. Analysis of the anisotropic spectral patterns from poly-crystalline systems reveal information concerning molecular structure and dynamics, yet in all but the simplest of systems, the overlap of spectral patterns from chemically distinct sites renders the spectral analysis difficult if not impossible. One solution to this problem is to perform multi-dimensional experiments where the high-resolution, isotropic spectrum in one dimension is correlated with the anisotropic spectral patterns in the other dimensions. The VACSY technique incorporates the angle between the spinner axis and the static magnetic field as an experimental parameter that may be incremented during the course of the experiment to help correlate the isotropic and anisotropic components of the spectrum. The two-dimensional version of the VACSY experiments is used to extract the chemical shift anisotropy tensor values from multi-site organic molecules, study molecular dynamics in the intermediate time regime, and to examine the ordering properties of partially oriented samples. The VACSY technique is then extended to three-dimensional experiments to study slow molecular reorientations in a multi-site polymer system

  11. Atypical squamous cells of undetermined significance in patients with HPV positive DNA testing and correlation with disease progression by age group: an institutional experience.

    Science.gov (United States)

    Rodriguez, Erika F; Reynolds, Jordan P; Jenkins, Sarah M; Winter, Stephanie M; Henry, Michael R; Nassar, Aziza

    2012-01-01

    Atypical squamous cells of undetermined significance (ASC-US) is a broad diagnostic category that could be attributed to human papillomavirus infection (HPV), malignant neoplasia and reactive conditions. We evaluated our institutional experience with ASC-US in women who are positive for high risk HPV (HRHPV+) by the Digene hybrid capture method from 2005-2009 to identify the risk of progression to squamous intraepithelial lesion (SIL) and cervical intraepithelial neoplasia (CIN) in association with age. We reviewed cytologic and follow-up surgical pathology reports for all specimens available. Progression was defined as a diagnosis of at least CINI on follow-up biopsy or resection or SIL on cytology. We identified 2613 cases and follow-up was available in 1839 (70.4%). Of these 74.2% had just one follow-up, 16.2% had a total of 2 follow-ups, 5.3% had a total of 3 follow-ups, and the remaining had as many as 6 follow-ups. Among the 1839 patients, 69.4% were age 30 or younger, 16.0% were between 31 to 40, 9.0% were between 41 to 50, and 5.6% were 51 or older. Among these, 25-30% progressed to dysplasia. The risk of progression varied by age (p=0.04) and was lowest among women between the ages of 41-50. Our findings highlight the importance of continued cytologic follow-up in women with HRHPV+ ASC-US in order to detect progression o