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Sample records for experimentally validated primers

  1. Experimental Design and Some Threats to Experimental Validity: A Primer

    Science.gov (United States)

    Skidmore, Susan

    2008-01-01

    Experimental designs are distinguished as the best method to respond to questions involving causality. The purpose of the present paper is to explicate the logic of experimental design and why it is so vital to questions that demand causal conclusions. In addition, types of internal and external validity threats are discussed. To emphasize the…

  2. A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance

    Directory of Open Access Journals (Sweden)

    Wang Xiaowei

    2008-12-01

    Full Text Available Abstract Background Quantitative polymerase chain reaction (QPCR is a widely applied analytical method for the accurate determination of transcript abundance. Primers for QPCR have been designed on a genomic scale but non-specific amplification of non-target genes has frequently been a problem. Although several online databases have been created for the storage and retrieval of experimentally validated primers, only a few thousand primer pairs are currently present in existing databases and the primers are not designed for use under a common PCR thermal profile. Results We previously reported the implementation of an algorithm to predict PCR primers for most known human and mouse genes. We now report the use of that resource to identify 17483 pairs of primers that have been experimentally verified to amplify unique sequences corresponding to distinct murine transcripts. The primer pairs have been validated by gel electrophoresis, DNA sequence analysis and thermal denaturation profile. In addition to the validation studies, we have determined the uniformity of amplification using the primers and the technical reproducibility of the QPCR reaction using the popular and inexpensive SYBR Green I detection method. Conclusion We have identified an experimentally validated collection of murine primer pairs for PCR and QPCR which can be used under a common PCR thermal profile, allowing the evaluation of transcript abundance of a large number of genes in parallel. This feature is increasingly attractive for confirming and/or making more precise data trends observed from experiments performed with DNA microarrays.

  3. An SAT® Validity Primer

    Science.gov (United States)

    Shaw, Emily J.

    2015-01-01

    This primer should provide the reader with a deeper understanding of the concept of test validity and will present the recent available validity evidence on the relationship between SAT® scores and important college outcomes. In addition, the content examined on the SAT will be discussed as well as the fundamental attention paid to the fairness of…

  4. QDD version 3.1: a user-friendly computer program for microsatellite selection and primer design revisited: experimental validation of variables determining genotyping success rate.

    Science.gov (United States)

    Meglécz, Emese; Pech, Nicolas; Gilles, André; Dubut, Vincent; Hingamp, Pascal; Trilles, Aurélie; Grenier, Rémi; Martin, Jean-François

    2014-11-01

    Microsatellite marker development has been greatly simplified by the use of high-throughput sequencing followed by in silico microsatellite detection and primer design. However, the selection of markers designed by the existing pipelines depends either on arbitrary criteria, or older studies on PCR success. Based on wet laboratory experiments, we have identified the following factors that are most likely to influence genotyping success rate: alignment score between the primers and the amplicon; the distance between primers and microsatellites; the length of the PCR product; target region complexity and the number of reads underlying the sequence. The QDD pipeline has been modified to include these most pertinent factors in the output to help the selection of markers. Furthermore, new features are also included in the present version: (i) not only raw sequencing reads are accepted as input, but also contigs, allowing the analysis of assembled high-coverage data; (ii) input data can be both in fasta and fastq format to facilitate the use of Illumina and IonTorrent reads; (iii) A comparison to known transposable elements allows their detection; (iv) A contamination check can be carried out by BLASTing potential markers against the nucleotide (nt) database of NCBI; (v) QDD3 is now also available imbedded into a virtual machine making installation easier and operating system independent. It can be used both on command-line version as well as integrated into a Galaxy server, providing a user-friendly interface, as well as the possibility to utilize a large variety of NGS tools. © 2014 John Wiley & Sons Ltd.

  5. Comparison and validation of some ITS primer pairs useful for fungal metabarcoding studies.

    Directory of Open Access Journals (Sweden)

    Michiel Op De Beeck

    Full Text Available Current metabarcoding studies aiming to characterize microbial communities generally rely on the amplification and sequencing of relatively short DNA regions. For fungi, the internal transcribed spacer (ITS region in the ribosomal RNA (rRNA operon has been accepted as the formal fungal barcode. Despite an increasing number of fungal metabarcoding studies, the amplification efficiency of primers is generally not tested prior to their application in metabarcoding studies. Some of the challenges that metabarcoding primers should overcome efficiently are the amplification of target DNA strands in samples rich in non-target DNA and environmental pollutants, such as humic acids, that may have been co-extracted with DNA. In the current study, three selected primer pairs were tested for their suitability as fungal metabarcoding primers. The selected primer pairs include two primer pairs that have been frequently used in fungal metabarcoding studies (ITS1F/ITS2 and ITS3/ITS4 and a primer pair (ITS86F/ITS4 that has been shown to efficiently amplify the ITS2 region of a broad range of fungal taxa in environmental soil samples. The selected primer pairs were evaluated in a 454 amplicon pyrosequencing experiment, real-time PCR (qPCR experiments and in silico analyses. Results indicate that experimental evaluation of primers provides valuable information that could aid in the selection of suitable primers for fungal metabarcoding studies. Furthermore, we show that the ITS86F/ITS4 primer pair outperforms other primer pairs tested in terms of in silico primer efficiency, PCR efficiency, coverage, number of reads and number of species-level operational taxonomic units (OTUs obtained. These traits push the ITS86F/ITS4 primer pair forward as highly suitable for studying fungal diversity and community structures using DNA metabarcoding.

  6. PEMFC modeling and experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Vargas, J.V.C. [Federal University of Parana (UFPR), Curitiba, PR (Brazil). Dept. of Mechanical Engineering], E-mail: jvargas@demec.ufpr.br; Ordonez, J.C.; Martins, L.S. [Florida State University, Tallahassee, FL (United States). Center for Advanced Power Systems], Emails: ordonez@caps.fsu.edu, martins@caps.fsu.edu

    2009-07-01

    In this paper, a simplified and comprehensive PEMFC mathematical model introduced in previous studies is experimentally validated. Numerical results are obtained for an existing set of commercial unit PEM fuel cells. The model accounts for pressure drops in the gas channels, and for temperature gradients with respect to space in the flow direction, that are investigated by direct infrared imaging, showing that even at low current operation such gradients are present in fuel cell operation, and therefore should be considered by a PEMFC model, since large coolant flow rates are limited due to induced high pressure drops in the cooling channels. The computed polarization and power curves are directly compared to the experimentally measured ones with good qualitative and quantitative agreement. The combination of accuracy and low computational time allow for the future utilization of the model as a reliable tool for PEMFC simulation, control, design and optimization purposes. (author)

  7. Multimicrophone Speech Dereverberation: Experimental Validation

    Directory of Open Access Journals (Sweden)

    Marc Moonen

    2007-05-01

    Full Text Available Dereverberation is required in various speech processing applications such as handsfree telephony and voice-controlled systems, especially when signals are applied that are recorded in a moderately or highly reverberant environment. In this paper, we compare a number of classical and more recently developed multimicrophone dereverberation algorithms, and validate the different algorithmic settings by means of two performance indices and a speech recognition system. It is found that some of the classical solutions obtain a moderate signal enhancement. More advanced subspace-based dereverberation techniques, on the other hand, fail to enhance the signals despite their high-computational load.

  8. Development and validation of an rDNA operon based primer walking strategy applicable to de novo bacterial genome finishing.

    Directory of Open Access Journals (Sweden)

    Alexander William Eastman

    2015-01-01

    Full Text Available Advances in sequencing technology have drastically increased the depth and feasibility of bacterial genome sequencing. However, little information is available that details the specific techniques and procedures employed during genome sequencing despite the large numbers of published genomes. Shotgun approaches employed by second-generation sequencing platforms has necessitated the development of robust bioinformatics tools for in silico assembly, and complete assembly is limited by the presence of repetitive DNA sequences and multi-copy operons. Typically, re-sequencing with multiple platforms and laborious, targeted Sanger sequencing are employed to finish a draft bacterial genome. Here we describe a novel strategy based on the identification and targeted sequencing of repetitive rDNA operons to expedite bacterial genome assembly and finishing. Our strategy was validated by finishing the genome of Paenibacillus polymyxa strain CR1, a bacterium with potential in sustainable agriculture and bio-based processes. An analysis of the 38 contigs contained in the P. polymyxa strain CR1 draft genome revealed 12 repetitive rDNA operons with varied intragenic and flanking regions of variable length, unanimously located at contig boundaries and within contig gaps. These highly similar but not identical rDNA operons were experimentally verified and sequenced simultaneously with multiple, specially designed primer sets. This approach also identified and corrected significant sequence rearrangement generated during the initial in silico assembly of sequencing reads. Our approach reduces the required effort associated with blind primer walking for contig assembly, increasing both the speed and feasibility of genome finishing. Our study further reinforces the notion that repetitive DNA elements are major limiting factors for genome finishing. Moreover, we provided a step-by-step workflow for genome finishing, which may guide future bacterial genome finishing

  9. Use of Hoy's solubility parameters to predict water sorption/solubility of experimental primers and adhesives.

    Science.gov (United States)

    Nishitani, Yoshihiro; Yoshiyama, Masahiro; Hosaka, Keiichi; Tagami, Junji; Donnelly, Adam; Carrilho, Marcela; Tay, Franklin R; Pashley, David H

    2007-02-01

    Self-etching primers and adhesives contain very hydrophilic acidic monomers that result in high water sorption/solubilities of their polymers. However, the chemical composition of these products varies widely. The purpose of this work was to vary the chemical composition of experimental self-etching primers and adhesives to determine if the water sorption/solubility of the polymers were affected in a predictable manner. The Hoy's solubility parameters of these mixtures were calculated to permit ranking of the degree of hydrophilicity of the polymers. Water sorption/solubility was measured according to ISO 4049. The results showed highly significant (R(2) = 0.86, P solubility parameter for polar forces (delta(p)) of the polymers. Similar correlations were obtained between polymer solubility and delta(p). When these results were compared with previously published results obtained with more hydrophobic resins, excellent correlations were obtained, indicating that Hoy's delta(p) values may be used to predict the water sorption behavior of methylmethacrylate polymers.

  10. Quantitative Experimental Determination of Primer-Dimer Formation Risk by Free-Solution Conjugate Electrophoresis

    OpenAIRE

    Desmarais, Samantha M.; Leitner, Thomas; Barron, Annelise E.

    2012-01-01

    DNA barcodes are short, unique ssDNA primers that “mark” individual biomolecules. To gain better understanding of biophysical parameters constraining primer-dimer formation between primers that incorporate barcode sequences, we have developed a capillary electrophoresis method that utilizes drag-tag-DNA conjugates to quantify dimerization risk between primer-barcode pairs. Results obtained with this unique free-solution conjugate electrophoresis (FSCE) approach are useful as quantitatively pr...

  11. Development and validation of a universal primer pair for the simultaneous detection of eight animal species.

    Science.gov (United States)

    Xue, Chaobo; Wang, Pingya; Zhao, Jin; Xu, Aichun; Guan, Feng

    2017-04-15

    In the present study, we developed a novel simplex PCR assay for the simultaneous detection of eight animal species, including goat, sheep, deer, buffalo, cattle, yak, pig and camel. A unique pair of universal primers was designed to target mitochondrial DNA variable regions in the eight animal species, generating, 787, 763, 563, 512, 507, 491, 455 and 385bp long fragments for goat, sheep, deer, buffalo, cattle, yak, pig and camel, respectively. The assay showed no cross-reactivity with other common domestic animals, and was validated by sequencing and enzyme digestion. Detection limit for DNA samples from the eight animal species varied between 6 and 20pg in a 20μl PCR mixture. Interestingly, the newly developed method successfully identified 170 commercial meat products, and is simple, fast, sensitive, specific, and cost-effective. Therefore, it could be used for the detection of goat, sheep, deer, buffalo, cattle, yak, pig, and camel species in foodstuffs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. PHUSER (Primer Help for USER): a novel tool for USER fusion primer design

    DEFF Research Database (Denmark)

    Olsen, Lars Rønn; Hansen, Niels Bjørn; Bonde, Mads

    2011-01-01

    Uracil-Specific Exision Reagent (USER) fusion is a recently developed technique that allows for assembly of multiple DNA fragments in a few simple steps. However, designing primers for USER fusion is both tedious and time consuming. Here, we present the Primer Help for USER (PHUSER) software......, a novel tool for designing primers specifically for USER fusion and USER cloning applications. We also present proof-of-concept experimental validation of its functionality. PHUSER offers quick and easy design of PCR optimized primers ensuring directionally correct fusion of fragments into a plasmid...... containing a customizable USER cassette. Designing primers using PHUSER ensures that the primers have similar annealing temperature (Tm), which is essential for efficient PCR. PHUSER also avoids identical overhangs, thereby ensuring correct order of assembly of DNA fragments. All possible primers...

  13. A new set of validated SSR primers for application in mulberry ...

    Indian Academy of Sciences (India)

    user

    2018-01-11

    Jan 11, 2018 ... Cluster analysis was performed using the data generated by 15. MulSatG primers with Rp >2 by Neighbour Joining method to check for the degree of resolution that could be achieved. Results and discussion. Sericulture is a cottage industry that employs 8.03 million people across India and generates.

  14. Lead acid batteries simulation including experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Achaibou, N.; Malek, A. [Division Energie Solaire Photovoltaique, Centre de Developpement des Energies Renouvelables, B.P. 62, Route de l' Observatoire, Bouzareah, Alger (Algeria); Haddadi, M. [Laboratoire de Dispositif de Communication et de Conversion Photovoltaique Ecole Nationale Polytechnique, Rue Hassen Badi, El Harrach, Alger (Algeria)

    2008-12-01

    The storage of energy in batteries is a cause of the failure and loss of reliability in PV systems. The battery behavior has been largely described in the literature by many authors; the selected models are of Monegon and CIEMAT. This paper reviews the two general lead acid battery models and their agreement with experimental data. In order to validate these models, the behavior of different battery cycling currents has been simulated. Results obtained have been compared to real data. The CIEMAT model presents a good performance compared to Monegon's model. (author)

  15. Seclazone Reactor Modeling And Experimental Validation

    Energy Technology Data Exchange (ETDEWEB)

    Osinga, T. [ETH-Zuerich (Switzerland); Olalde, G. [CNRS Odeillo (France); Steinfeld, A. [PSI and ETHZ (Switzerland)

    2005-03-01

    A numerical model is formulated for the SOLZINC solar chemical reactor for the production of Zn by carbothermal reduction of ZnO. The model involves solving, by the finite-volume technique, a 1D unsteady state energy equation that couples heat transfer to the chemical kinetics for a shrinking packed bed exposed to thermal radiation. Validation is accomplished by comparison with experimentally measured temperature profiles and Zn production rates as a function of time, obtained for a 5-kW solar reactor tested at PSI's solar furnace. (author)

  16. De-MetaST-BLAST: a tool for the validation of degenerate primer sets and data mining of publicly available metagenomes.

    Directory of Open Access Journals (Sweden)

    Christopher A Gulvik

    Full Text Available Development and use of primer sets to amplify nucleic acid sequences of interest is fundamental to studies spanning many life science disciplines. As such, the validation of primer sets is essential. Several computer programs have been created to aid in the initial selection of primer sequences that may or may not require multiple nucleotide combinations (i.e., degeneracies. Conversely, validation of primer specificity has remained largely unchanged for several decades, and there are currently few available programs that allows for an evaluation of primers containing degenerate nucleotide bases. To alleviate this gap, we developed the program De-MetaST that performs an in silico amplification using user defined nucleotide sequence dataset(s and primer sequences that may contain degenerate bases. The program returns an output file that contains the in silico amplicons. When De-MetaST is paired with NCBI's BLAST (De-MetaST-BLAST, the program also returns the top 10 nr NCBI database hits for each recovered in silico amplicon. While the original motivation for development of this search tool was degenerate primer validation using the wealth of nucleotide sequences available in environmental metagenome and metatranscriptome databases, this search tool has potential utility in many data mining applications.

  17. PrecisePrimer: an easy-to-use web server for designing PCR primers for DNA library cloning and DNA shuffling

    Science.gov (United States)

    Pauthenier, Cyrille; Faulon, Jean-Loup

    2014-01-01

    PrecisePrimer is a web-based primer design software made to assist experimentalists in any repetitive primer design task such as preparing, cloning and shuffling DNA libraries. Unlike other popular primer design tools, it is conceived to generate primer libraries with popular PCR polymerase buffers proposed as pre-set options. PrecisePrimer is also meant to design primers in batches, such as for DNA libraries creation of DNA shuffling experiments and to have the simplest interface possible. It integrates the most up-to-date melting temperature algorithms validated with experimental data, and cross validated with other computational tools. We generated a library of primers for the extraction and cloning of 61 genes from yeast DNA genomic extract using default parameters. All primer pairs efficiently amplified their target without any optimization of the PCR conditions. PMID:24829457

  18. Experimental validation of wireless communication with chaos

    Science.gov (United States)

    Ren, Hai-Peng; Bai, Chao; Liu, Jian; Baptista, Murilo S.; Grebogi, Celso

    2016-08-01

    The constraints of a wireless physical media, such as multi-path propagation and complex ambient noises, prevent information from being communicated at low bit error rate. Surprisingly, it has only recently been shown that, from a theoretical perspective, chaotic signals are optimal for communication. It maximises the receiver signal-to-noise performance, consequently minimizing the bit error rate. This work demonstrates numerically and experimentally that chaotic systems can in fact be used to create a reliable and efficient wireless communication system. Toward this goal, we propose an impulsive control method to generate chaotic wave signals that encode arbitrary binary information signals and an integration logic together with the match filter capable of decreasing the noise effect over a wireless channel. The experimental validation is conducted by inputting the signals generated by an electronic transmitting circuit to an electronic circuit that emulates a wireless channel, where the signals travel along three different paths. The output signal is decoded by an electronic receiver, after passing through a match filter.

  19. Experimental validation of wireless communication with chaos.

    Science.gov (United States)

    Ren, Hai-Peng; Bai, Chao; Liu, Jian; Baptista, Murilo S; Grebogi, Celso

    2016-08-01

    The constraints of a wireless physical media, such as multi-path propagation and complex ambient noises, prevent information from being communicated at low bit error rate. Surprisingly, it has only recently been shown that, from a theoretical perspective, chaotic signals are optimal for communication. It maximises the receiver signal-to-noise performance, consequently minimizing the bit error rate. This work demonstrates numerically and experimentally that chaotic systems can in fact be used to create a reliable and efficient wireless communication system. Toward this goal, we propose an impulsive control method to generate chaotic wave signals that encode arbitrary binary information signals and an integration logic together with the match filter capable of decreasing the noise effect over a wireless channel. The experimental validation is conducted by inputting the signals generated by an electronic transmitting circuit to an electronic circuit that emulates a wireless channel, where the signals travel along three different paths. The output signal is decoded by an electronic receiver, after passing through a match filter.

  20. Experimental validation of ultrasonic NDE simulation software

    Science.gov (United States)

    Dib, Gerges; Larche, Michael; Diaz, Aaron A.; Crawford, Susan L.; Prowant, Matthew S.; Anderson, Michael T.

    2016-02-01

    Computer modeling and simulation is becoming an essential tool for transducer design and insight into ultrasonic nondestructive evaluation (UT-NDE). As the popularity of simulation tools for UT-NDE increases, it becomes important to assess their reliability to model acoustic responses from defects in operating components and provide information that is consistent with in-field inspection data. This includes information about the detectability of different defect types for a given UT probe. Recently, a cooperative program between the Electrical Power Research Institute and the U.S. Nuclear Regulatory Commission was established to validate numerical modeling software commonly used for simulating UT-NDE of nuclear power plant components. In the first phase of this cooperative, extensive experimental UT measurements were conducted on machined notches with varying depth, length, and orientation in stainless steel plates. Then, the notches were modeled in CIVA, a semi-analytical NDE simulation platform developed by the French Commissariat a l'Energie Atomique, and their responses compared with the experimental measurements. Discrepancies between experimental and simulation results are due to either improper inputs to the simulation model, or to incorrect approximations and assumptions in the numerical models. To address the former, a variation study was conducted on the different parameters that are required as inputs for the model, specifically the specimen and transducer properties. Then, the ability of simulations to give accurate predictions regarding the detectability of the different defects was demonstrated. This includes the results in terms of the variations in defect amplitude indications, and the ratios between tip diffracted and specular signal amplitudes.

  1. Bracket bond strength comparison between new unfilled experimental self-etching primer adhesive and conventional filled adhesives.

    Science.gov (United States)

    Iijima, Masahiro; Ito, Shuichi; Muguruma, Takeshi; Saito, Takashi; Mizoguchi, Itaru

    2010-11-01

    To determine if a new unfilled experimental self-etching primer (SEP) adhesive system (SBP-40TX + C&B Metabond) that incorporates a methyl methacrylate-based 4-META/TBB (4-methacryloxyethyl trimellitate anhydride tri-n-butyl borane) resin can provide adequate shear bond strength (SBS) when used for bonding orthodontic brackets. Forty-eight human maxillary premolars were randomly divided into three groups of 16 specimens each. Brackets were bonded with three bonding systems. A filled Bis-GMA/TEGDM (triethylene glycol dimethacrylate)-based SEP adhesive system (Transbond Plus) and an unfilled conventional etch-and-rinse adhesive system (C&B Metabond) were used for comparison. The SBS for each sample was examined with a universal testing machine, and the Adhesive Remnant Index score was calculated. Enamel surfaces after conditioning were examined using a scanning electron microscope. Data were compared by one-way analysis of variance and a chi(2) test. The experimental SEP showed a milder etching pattern than Transbond Plus SEP. No statistically significant differences in the mean SBS were found between the specimens bonded with the unfilled experimental SEP adhesive system (10.0 MPa) and the filled SEP adhesive system (8.7 MPa). The unfilled experimental SEP adhesive system showed less residual adhesive than the filled SEP adhesive system. The unfilled experimental SEP adhesive system showed a clinically sufficient SBS that was equivalent to the filled SEP adhesive system.

  2. PHUSER (Primer Help for USER): a novel tool for USER fusion primer design.

    Science.gov (United States)

    Olsen, Lars Rønn; Hansen, Niels Bjørn; Bonde, Mads Tvillinggaard; Genee, Hans Jasper; Holm, Dorte Koefoed; Carlsen, Simon; Hansen, Bjarne Gram; Patil, Kiran Raosaheb; Mortensen, Uffe Hasbro; Wernersson, Rasmus

    2011-07-01

    Uracil-Specific Exision Reagent (USER) fusion is a recently developed technique that allows for assembly of multiple DNA fragments in a few simple steps. However, designing primers for USER fusion is both tedious and time consuming. Here, we present the Primer Help for USER (PHUSER) software, a novel tool for designing primers specifically for USER fusion and USER cloning applications. We also present proof-of-concept experimental validation of its functionality. PHUSER offers quick and easy design of PCR optimized primers ensuring directionally correct fusion of fragments into a plasmid containing a customizable USER cassette. Designing primers using PHUSER ensures that the primers have similar annealing temperature (T(m)), which is essential for efficient PCR. PHUSER also avoids identical overhangs, thereby ensuring correct order of assembly of DNA fragments. All possible primers are individually analysed in terms of GC content, presence of GC clamp at 3'-end, the risk of primer dimer formation, the risk of intra-primer complementarity (secondary structures) and the presence of polyN stretches. Furthermore, PHUSER offers the option to insert linkers between DNA fragments, as well as highly flexible cassette options. PHUSER is publicly available at http://www.cbs.dtu.dk/services/phuser/.

  3. URPD: a specific product primer design tool.

    Science.gov (United States)

    Chuang, Li-Yeh; Cheng, Yu-Huei; Yang, Cheng-Hong

    2012-06-19

    Polymerase chain reaction (PCR) plays an important role in molecular biology. Primer design fundamentally determines its results. Here, we present a currently available software that is not located in analyzing large sequence but used for a rather straight-forward way of visualizing the primer design process for infrequent users. URPD (yoUR Primer Design), a web-based specific product primer design tool, combines the NCBI Reference Sequences (RefSeq), UCSC In-Silico PCR, memetic algorithm (MA) and genetic algorithm (GA) primer design methods to obtain specific primer sets. A friendly user interface is accomplished by built-in parameter settings. The incorporated smooth pipeline operations effectively guide both occasional and advanced users. URPD contains an automated process, which produces feasible primer pairs that satisfy the specific needs of the experimental design with practical PCR amplifications. Visual virtual gel electrophoresis and in silico PCR provide a simulated PCR environment. The comparison of Practical gel electrophoresis comparison to virtual gel electrophoresis facilitates and verifies the PCR experiment. Wet-laboratory validation proved that the system provides feasible primers. URPD is a user-friendly tool that provides specific primer design results. The pipeline design path makes it easy to operate for beginners. URPD also provides a high throughput primer design function. Moreover, the advanced parameter settings assist sophisticated researchers in performing experiential PCR. Several novel functions, such as a nucleotide accession number template sequence input, local and global specificity estimation, primer pair redesign, user-interactive sequence scale selection, and virtual and practical PCR gel electrophoresis discrepancies have been developed and integrated into URPD. The URPD program is implemented in JAVA and freely available at http://bio.kuas.edu.tw/urpd/.

  4. URPD: a specific product primer design tool

    Directory of Open Access Journals (Sweden)

    Chuang Li-Yeh

    2012-06-01

    Full Text Available Abstract Background Polymerase chain reaction (PCR plays an important role in molecular biology. Primer design fundamentally determines its results. Here, we present a currently available software that is not located in analyzing large sequence but used for a rather straight-forward way of visualizing the primer design process for infrequent users. Findings URPD (yoUR Primer Design, a web-based specific product primer design tool, combines the NCBI Reference Sequences (RefSeq, UCSC In-Silico PCR, memetic algorithm (MA and genetic algorithm (GA primer design methods to obtain specific primer sets. A friendly user interface is accomplished by built-in parameter settings. The incorporated smooth pipeline operations effectively guide both occasional and advanced users. URPD contains an automated process, which produces feasible primer pairs that satisfy the specific needs of the experimental design with practical PCR amplifications. Visual virtual gel electrophoresis and in silico PCR provide a simulated PCR environment. The comparison of Practical gel electrophoresis comparison to virtual gel electrophoresis facilitates and verifies the PCR experiment. Wet-laboratory validation proved that the system provides feasible primers. Conclusions URPD is a user-friendly tool that provides specific primer design results. The pipeline design path makes it easy to operate for beginners. URPD also provides a high throughput primer design function. Moreover, the advanced parameter settings assist sophisticated researchers in performing experiential PCR. Several novel functions, such as a nucleotide accession number template sequence input, local and global specificity estimation, primer pair redesign, user-interactive sequence scale selection, and virtual and practical PCR gel electrophoresis discrepancies have been developed and integrated into URPD. The URPD program is implemented in JAVA and freely available at http://bio.kuas.edu.tw/urpd/.

  5. Experimental validation of navigation workload metrics

    Energy Technology Data Exchange (ETDEWEB)

    Schryver, J.C. [Oak Ridge National Lab., TN (United States); Wachtel, J.A. [Nuclear Regulatory Commission, Rockville, MD (United States). Office of Nuclear Regulatory Research

    1994-04-01

    Advanced digital computer display interfaces in the control room may increase operator workload. Workstation monitors provide limited display area, and information is represented in large-scale display networks. Display navigation may generate disorienting effects, require additional resources for window management, and increase memory and data integration requirements. Six ORNL employees participated in an experiment to validate proposed metrics of navigation workload in the advanced control room. The task environment was a display network consisting of 25 windows resembling a simplified Safety Parameter Display System for Pressurized Water Reactors. A repeated measures design with 3 within subjects factors was employed. The factors were task difficulty, navigation distance level, and a blocking factor. Participants were asked to monitor a single parameter or two parameters. Fourteen candidate metrics were tested. Analysis of variance of the modified task load index (MTLX) and rating subscales demonstrated substantial support for the claim that navigation of large-scale display networks can impose additional mental load. Primary and secondary task performance measures exhibited ceiling effects. Memory probes for these tasks were inadequate because they were recognition-based and coarse. Eye gaze measures were not validated, indicating a need for more refined data reduction algorithms. Strong positive correlations were found between MTLX and both navigation duration and standard deviation of pupil diameter. Further study and increased statistical power are required to validate objective navigation workload metrics.

  6. Experimental validation of the hepatoprotective and anticancer ...

    African Journals Online (AJOL)

    Vernonia amygdalina (VA) is a medicinal shrub useful for the treatment of various diseases including cancer and liver diseases. It is often utilised as edible vegetable. This review aims at logically examining experimental evidences supporting the use of V. amygdalina in folklore medicine. Several databases including ...

  7. Experimentally Induced Stress Validated by EMG Activity

    Science.gov (United States)

    Luijcks, Rosan; Hermens, Hermie J.; Bodar, Lonneke; Vossen, Catherine J.; Os, Jim van.; Lousberg, Richel

    2014-01-01

    Experience of stress may lead to increased electromyography (EMG) activity in specific muscles compared to a non-stressful situation. The main aim of this study was to develop and validate a stress-EMG paradigm in which a single uncontrollable and unpredictable nociceptive stimulus was presented. EMG activity of the trapezius muscles was the response of interest. In addition to linear time effects, non-linear EMG time courses were also examined. Taking into account the hierarchical structure of the dataset, a multilevel random regression model was applied. The stress paradigm, executed in N = 70 subjects, consisted of a 3-minute baseline measurement, a 3-minute pre-stimulus stress period and a 2-minute post-stimulus phase. Subjects were unaware of the precise moment of stimulus delivery and its intensity level. EMG activity during the entire experiment was conform a priori expectations: the pre-stimulus phase showed a significantly higher mean EMG activity level compared to the other two phases, and an immediate EMG response to the stimulus was demonstrated. In addition, the analyses revealed significant non-linear EMG time courses in all three phases. Linear and quadratic EMG time courses were significantly modified by subjective anticipatory stress level, measured just before the start of the stress task. Linking subjective anticipatory stress to EMG stress reactivity revealed that subjects with a high anticipatory stress level responded with more EMG activity during the pre-stimulus stress phase, whereas subjects with a low stress level showed an inverse effect. Results suggest that the stress paradigm presented here is a valid test to quantify individual differences in stress susceptibility. Further studies with this paradigm are required to demonstrate its potential use in mechanistic clinical studies. PMID:24736740

  8. Experimentally induced stress validated by EMG activity.

    Science.gov (United States)

    Luijcks, Rosan; Hermens, Hermie J; Bodar, Lonneke; Vossen, Catherine J; Van Os, Jim; Lousberg, Richel

    2014-01-01

    Experience of stress may lead to increased electromyography (EMG) activity in specific muscles compared to a non-stressful situation. The main aim of this study was to develop and validate a stress-EMG paradigm in which a single uncontrollable and unpredictable nociceptive stimulus was presented. EMG activity of the trapezius muscles was the response of interest. In addition to linear time effects, non-linear EMG time courses were also examined. Taking into account the hierarchical structure of the dataset, a multilevel random regression model was applied. The stress paradigm, executed in N = 70 subjects, consisted of a 3-minute baseline measurement, a 3-minute pre-stimulus stress period and a 2-minute post-stimulus phase. Subjects were unaware of the precise moment of stimulus delivery and its intensity level. EMG activity during the entire experiment was conform a priori expectations: the pre-stimulus phase showed a significantly higher mean EMG activity level compared to the other two phases, and an immediate EMG response to the stimulus was demonstrated. In addition, the analyses revealed significant non-linear EMG time courses in all three phases. Linear and quadratic EMG time courses were significantly modified by subjective anticipatory stress level, measured just before the start of the stress task. Linking subjective anticipatory stress to EMG stress reactivity revealed that subjects with a high anticipatory stress level responded with more EMG activity during the pre-stimulus stress phase, whereas subjects with a low stress level showed an inverse effect. Results suggest that the stress paradigm presented here is a valid test to quantify individual differences in stress susceptibility. Further studies with this paradigm are required to demonstrate its potential use in mechanistic clinical studies.

  9. Experimentally induced stress validated by EMG activity.

    Directory of Open Access Journals (Sweden)

    Rosan Luijcks

    Full Text Available Experience of stress may lead to increased electromyography (EMG activity in specific muscles compared to a non-stressful situation. The main aim of this study was to develop and validate a stress-EMG paradigm in which a single uncontrollable and unpredictable nociceptive stimulus was presented. EMG activity of the trapezius muscles was the response of interest. In addition to linear time effects, non-linear EMG time courses were also examined. Taking into account the hierarchical structure of the dataset, a multilevel random regression model was applied. The stress paradigm, executed in N = 70 subjects, consisted of a 3-minute baseline measurement, a 3-minute pre-stimulus stress period and a 2-minute post-stimulus phase. Subjects were unaware of the precise moment of stimulus delivery and its intensity level. EMG activity during the entire experiment was conform a priori expectations: the pre-stimulus phase showed a significantly higher mean EMG activity level compared to the other two phases, and an immediate EMG response to the stimulus was demonstrated. In addition, the analyses revealed significant non-linear EMG time courses in all three phases. Linear and quadratic EMG time courses were significantly modified by subjective anticipatory stress level, measured just before the start of the stress task. Linking subjective anticipatory stress to EMG stress reactivity revealed that subjects with a high anticipatory stress level responded with more EMG activity during the pre-stimulus stress phase, whereas subjects with a low stress level showed an inverse effect. Results suggest that the stress paradigm presented here is a valid test to quantify individual differences in stress susceptibility. Further studies with this paradigm are required to demonstrate its potential use in mechanistic clinical studies.

  10. Development, validation and application of specific primers for analyzing the clostridial diversity in dark fermentation pit mud by PCR-DGGE.

    Science.gov (United States)

    Hu, Xiao-Long; Wang, Hai-Yan; Wu, Qun; Xu, Yan

    2014-07-01

    In this study, a Clostridia-specific primer set SJ-F and SJ-R, based on the available 16S rRNA genes sequences from database, was successfully designed and authenticated by theoretical and experimental evaluations. It targeted 19 clostridial families and unclassified_Clostridia with different coverage rates. The specificity and universality of novel primer set was tested again using the dark fermentation pit mud (FPM). It was demonstrated that a total of 13 closest relatives including 12 species were affiliated with 7 clostridial genera, respectively. Compared to the well-accepted bacterial universal primer pair P2/P3, five unexpected clostridial genera including Roseburia, Tissierella, Sporanaerobacter, Alkalibacter and Halothermothrix present in the FPM were also revealed. Therefore, this study could provide a good alternative to investigate the clostridial diversity and monitor their population dynamics rapidly and efficiently in various anaerobic environments and dark fermentation systems in future. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Robust statistical methods: A primer for clinical psychology and experimental psychopathology researchers.

    Science.gov (United States)

    Field, Andy P; Wilcox, Rand R

    2017-11-01

    This paper reviews and offers tutorials on robust statistical methods relevant to clinical and experimental psychopathology researchers. We review the assumptions of one of the most commonly applied models in this journal (the general linear model, GLM) and the effects of violating them. We then present evidence that psychological data are more likely than not to violate these assumptions. Next, we overview some methods for correcting for violations of model assumptions. The final part of the paper presents 8 tutorials of robust statistical methods using R that cover a range of variants of the GLM (t-tests, ANOVA, multiple regression, multilevel models, latent growth models). We conclude with recommendations that set the expectations for what methods researchers submitting to the journal should apply and what they should report. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. A primer on experimental and computational rheology with fractional viscoelastic constitutive models

    Science.gov (United States)

    Ferrás, Luís Lima; Ford, Neville John; Morgado, Maria Luísa; Rebelo, Magda; McKinley, Gareth Huw; Nóbrega, João Miguel

    2017-05-01

    This work presents a brief introduction to fractional calculus and its application to some problems in rheology. We present two different viscoelastic models based on fractional derivatives (the Fractional Maxwell Model - FMM and the Fractional Viscoelastic Fluid - FVF) and discuss their reduction to the classical Newtonian and Maxwell fluids. A third model is also studied (an extension of the FMM to an invariant form), being given by a combination of the K-BKZ integral model with a fractional memory function which we denote the Fractional K-BKZ model. We discuss and illustrate the ability of these models to fit experimental data, and present numerical results for simple stress relaxation following step strain and steady shearing.

  13. MPprimer: a program for reliable multiplex PCR primer design

    Directory of Open Access Journals (Sweden)

    Wang Xiaolei

    2010-03-01

    Full Text Available Abstract Background Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set (comprising a forward primer and a reverse primer in one tube, has been widely used in diagnostic applications of clinical and environmental microbiology studies. However, primer design for multiplex PCR is still a challenging problem and several factors need to be considered. These problems include mis-priming due to nonspecific binding to non-target DNA templates, primer dimerization, and the inability to separate and purify DNA amplicons with similar electrophoretic mobility. Results A program named MPprimer was developed to help users for reliable multiplex PCR primer design. It employs the widely used primer design program Primer3 and the primer specificity evaluation program MFEprimer to design and evaluate the candidate primers based on genomic or transcript DNA database, followed by careful examination to avoid primer dimerization. The graph-expanding algorithm derived from the greedy algorithm was used to determine the optimal primer set combinations (PSCs for multiplex PCR assay. In addition, MPprimer provides a virtual electrophotogram to help users choose the best PSC. The experimental validation from 2× to 5× plex PCR demonstrates the reliability of MPprimer. As another example, MPprimer is able to design the multiplex PCR primers for DMD (dystrophin gene which caused Duchenne Muscular Dystrophy, which has 79 exons, for 20×, 20×, 20×, 14×, and 5× plex PCR reactions in five tubes to detect underlying exon deletions. Conclusions MPprimer is a valuable tool for designing specific, non-dimerizing primer set combinations with constrained amplicons size for multiplex PCR assays.

  14. Contact Modelling in Resistance Welding, Part II: Experimental Validation

    DEFF Research Database (Denmark)

    Song, Quanfeng; Zhang, Wenqi; Bay, Niels

    2006-01-01

    Contact algorithms in resistance welding presented in the previous paper are experimentally validated in the present paper. In order to verify the mechanical contact algorithm, two types of experiments, i.e. sandwich upsetting of circular, cylindrical specimens and compression tests of discs...... with a solid ring projection towards a flat ring, are carried out at room temperature. The complete algorithm, involving not only the mechanical model but also the thermal and electrical models, is validated by projection welding experiments. The experimental results are in satisfactory agreement...... with the simulation prediction, showing the validity of the algorithm....

  15. Experimental validation of a topology optimized acoustic cavity

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Sigmund, Ole; Fernandez Grande, Efren

    2015-01-01

    This paper presents the experimental validation of an acoustic cavity designed using topology optimization with the goal of minimizing the sound pressure locally for monochromatic excitation. The presented results show good agreement between simulations and measurements. The effect of damping, er......, errors in the production of the cavity, and variations in operating frequency is discussed and the importance of taking these factors into account in the modeling process is highlighted.......This paper presents the experimental validation of an acoustic cavity designed using topology optimization with the goal of minimizing the sound pressure locally for monochromatic excitation. The presented results show good agreement between simulations and measurements. The effect of damping...

  16. Passive RF Tomography: Signal Processing and Experimental Validation

    Science.gov (United States)

    2014-03-27

    SIGNAL PROCESSING AND EXPERIMENTAL VALIDATION THESIS Presented to the Faculty Department of Electrical Engineering Graduate...Fulfillment of the Requirements for the Degree of Master of Science in Electrical Engineering Thang M. Tran, B.S.E.E Civilian Student, USAF... Peebles , Radar Principles , New York: Wiley-Interscience, 1998. [15] R. Nitzberg, Radar signal processing and adaptive systems, Boston: Artech House

  17. An experimental method for validating compressor valve vibration theory

    NARCIS (Netherlands)

    Habing, R.A.; Peters, M.C.A.M.

    2006-01-01

    This paper presents an experimental method for validating traditional compressor valve theory for unsteady flow conditions. Traditional valve theory considers the flow force acting on the plate and the flow rate as quasi-steady variables. These variables are related via semi-empirical coefficients

  18. NEAMS Experimental Support for Code Validation, INL FY2009

    Energy Technology Data Exchange (ETDEWEB)

    G. Youinou; G. Palmiotti; M. Salvatore; C. Rabiti

    2009-09-01

    The goal is for all modeling and simulation tools to be demonstrated accurate and reliable through a formal Verification and Validation (V&V) process, especially where such tools are to be used to establish safety margins and support regulatory compliance, or to design a system in a manner that reduces the role of expensive mockups and prototypes. Whereas the Verification part of the process does not rely on experiment, the Validation part, on the contrary, necessitates as many relevant and precise experimental data as possible to make sure the models reproduce reality as closely as possible. Hence, this report presents a limited selection of experimental data that could be used to validate the codes devoted mainly to Fast Neutron Reactor calculations in the US. Emphasis has been put on existing data for thermal-hydraulics, fuel and reactor physics. The principles of a new “smart” experiment that could be used to improve our knowledge of neutron cross-sections are presented as well. In short, it consists in irradiating a few milligrams of actinides and analyzing the results with Accelerator Mass Spectroscopy to infer the neutron cross-sections. Finally, the wealth of experimental data relevant to Fast Neutron Reactors in the US should not be taken for granted and efforts should be put on saving these 30-40 years old data and on making sure they are validation-worthy, i.e. that the experimental conditions and uncertainties are well documented.

  19. experimental validation of optimum resistance moment of concrete ...

    African Journals Online (AJOL)

    user

    Fibre-Reinforced Plastics (FRPs) have been suggested as suitable reinforcement for concrete structures among other solutions to combat corrosion problems in steel reinforced concrete. This paper presents the experimental validation of optimum resistance moment of concrete slabs reinforced with Carbon-Fibre ...

  20. Experimental validation of optimum resistance moment of concrete ...

    African Journals Online (AJOL)

    Fibre-Reinforced Plastics (FRPs) have been suggested as suitable reinforcement for concrete structures among other solutions to combat corrosion problems in steel reinforced concrete. This paper presents the experimental validation of optimum resistance moment of concrete slabs reinforced with Carbon-Fibre ...

  1. Experimental Validation of an Integrated Controls-Structures Design Methodology

    Science.gov (United States)

    Maghami, Peiman G.; Gupta, Sandeep; Elliot, Kenny B.; Walz, Joseph E.

    1996-01-01

    The first experimental validation of an integrated controls-structures design methodology for a class of large order, flexible space structures is described. Integrated redesign of the controls-structures-interaction evolutionary model, a laboratory testbed at NASA Langley, was described earlier. The redesigned structure was fabricated, assembled in the laboratory, and experimentally tested against the original structure. Experimental results indicate that the structure redesigned using the integrated design methodology requires significantly less average control power than the nominal structure with control-optimized designs, while maintaining the required line-of-sight pointing performance. Thus, the superiority of the integrated design methodology over the conventional design approach is experimentally demonstrated. Furthermore, amenability of the integrated design structure to other control strategies is evaluated, both analytically and experimentally. Using Linear-Quadratic-Guassian optimal dissipative controllers, it is observed that the redesigned structure leads to significantly improved performance with alternate controllers as well.

  2. Development of genomic microsatellite multiplex PCR using dye-labeled universal primer and its validation in pedigree analysis of Pacific oyster ( Crassostrea gigas)

    Science.gov (United States)

    Liu, Ting; Li, Qi; Song, Junlin; Yu, Hong

    2017-02-01

    There is an increasing requirement for traceability of aquaculture products, both for consumer protection and for food safety. There are high error rates in the conventional traceability systems depending on physical labels. Genetic traceability technique depending on DNA-based tracking system can overcome this problem. Genealogy information is essential for genetic traceability, and microsatellite DNA marker is a good choice for pedigree analysis. As increasing genotyping throughput of microsatellites, microsatellite multiplex PCR has become a fast and cost-effective technique. As a commercially important cultured aquatic species, Pacific oyster Crassostrea gigas has the highest global production. The objective of this study was to develop microsatellite multiplex PCR panels with dye-labeled universal primer for pedigree analysis in C. gigas, and these multiplex PCRs were validated using 12 full-sib families with known pedigrees. Here we developed six informative multiplex PCRs using 18 genomic microsatellites in C. gigas. Each multiplex panel contained a single universal primer M13(-21) used as a tail on each locus-specific forward primer and a single universal primer M13(-21) labeled with fluorophores. The polymorphisms of the markers were moderate, with an average of 10.3 alleles per locus and average polymorphic information content of 0.740. The observed heterozygosity per locus ranged from 0.492 to 0.822. Cervus simulations revealed that the six panels would still be of great value when massive families were analysed. Pedigree analysis of real offspring demonstrated that 100% of the offspring were unambiguously allocated to their parents when two multiplex PCRs were used. The six sets of multiplex PCRs can be an important tool for tracing cultured individuals, population genetic analysis, and selective breeding program in C. gigas.

  3. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  4. Experimental validation of a topology optimized acoustic cavity.

    Science.gov (United States)

    Christiansen, Rasmus E; Sigmund, Ole; Fernandez-Grande, Efren

    2015-12-01

    This paper presents the experimental validation of an acoustic cavity designed using topology optimization with the goal of minimizing the sound pressure locally for monochromatic excitation. The presented results show good agreement between simulations and measurements. The effect of damping, errors in the production of the cavity, and variations in operating frequency is discussed and the importance of taking these factors into account in the modeling process is highlighted.

  5. Development and experimental validation of a protein design software

    OpenAIRE

    Stiebritz, Martin

    2008-01-01

    Computational protein design - understood as the prediction of an amino acid sequence that will adopt a given 3-dimensional structure associated with a desired function - offers the promising perspective of tailoring proteins according to special needs. From a more fundamental point of view, it improves our understanding of protein architecture, folding and dynamics. Here, the development and experimental validation of a protein design software - MUMBO - is described. The current implementati...

  6. INL Experimental Program Roadmap for Thermal Hydraulic Code Validation

    Energy Technology Data Exchange (ETDEWEB)

    Glenn McCreery; Hugh McIlroy

    2007-09-01

    Advanced computer modeling and simulation tools and protocols will be heavily relied on for a wide variety of system studies, engineering design activities, and other aspects of the Next Generation Nuclear Power (NGNP) Very High Temperature Reactor (VHTR), the DOE Global Nuclear Energy Partnership (GNEP), and light-water reactors. The goal is for all modeling and simulation tools to be demonstrated accurate and reliable through a formal Verification and Validation (V&V) process, especially where such tools are to be used to establish safety margins and support regulatory compliance, or to design a system in a manner that reduces the role of expensive mockups and prototypes. Recent literature identifies specific experimental principles that must be followed in order to insure that experimental data meet the standards required for a “benchmark” database. Even for well conducted experiments, missing experimental details, such as geometrical definition, data reduction procedures, and manufacturing tolerances have led to poor Benchmark calculations. The INL has a long and deep history of research in thermal hydraulics, especially in the 1960s through 1980s when many programs such as LOFT and Semiscle were devoted to light-water reactor safety research, the EBRII fast reactor was in operation, and a strong geothermal energy program was established. The past can serve as a partial guide for reinvigorating thermal hydraulic research at the laboratory. However, new research programs need to fully incorporate modern experimental methods such as measurement techniques using the latest instrumentation, computerized data reduction, and scaling methodology. The path forward for establishing experimental research for code model validation will require benchmark experiments conducted in suitable facilities located at the INL. This document describes thermal hydraulic facility requirements and candidate buildings and presents examples of suitable validation experiments related

  7. Experimental Validation of the Reverberation Effect in Room Electromagnetics

    DEFF Research Database (Denmark)

    Steinböck, Gerhard; Pedersen, Troels; Fleury, Bernard Henri

    2015-01-01

    The delay power spectrum is widely used in both communication and localization communities for characterizing the temporal dispersion of the radio channel. Experimental investigations of in-room radio environments indicate that the delay power spectrum exhibits an exponentially decaying tail....... This tail can be characterized with Sabine's or Eyring's reverberation models, which were initially developed in acoustics. So far, these models were only fitted to data collected from radio measurements, but no thorough validation of their prediction ability in electromagnetics has been performed yet....... This paper provides a contribution to fill this gap. We follow Sabine's original experimental approach, which consists in comparing model predictions to experimental observations in a room, while varying its mean absorption coefficient and total room surface. We find that Eyring's model provides a more...

  8. Stiffness analysis and experimental validation of robotic systems

    Science.gov (United States)

    Carbone, Giuseppe

    2011-06-01

    Stiffness can be considered of primary importance in order to guarantee the successful use of any robotic system for a given task. Therefore, this paper proposes procedures for carrying out both numerical and experimental estimations of stiffness performance for multibody robotic systems. The proposed numerical procedure is based on models with lumped parameters for deriving the Cartesian stiffness matrix. Stiffness performance indices are also proposed for comparing stiffness performance. Then, an experimental procedure for the evaluation stiffness performance is proposed as based on a new measuring system named as Milli-CATRASYS (Milli Cassino Tracking System) and on a trilateration technique. Cases of study are reported to show the soundness and engineering feasibility of both the proposed numerical formulation for stiffness analysis and experimental validation of stiffness performance.

  9. Experimental Validation of a Dynamic Model for Lightweight Robots

    Directory of Open Access Journals (Sweden)

    Alessandro Gasparetto

    2013-03-01

    Full Text Available Nowadays, one of the main topics in robotics research is dynamic performance improvement by means of a lightening of the overall system structure. The effective motion and control of these lightweight robotic systems occurs with the use of suitable motion planning and control process. In order to do so, model-based approaches can be adopted by exploiting accurate dynamic models that take into account the inertial and elastic terms that are usually neglected in a heavy rigid link configuration. In this paper, an effective method for modelling spatial lightweight industrial robots based on an Equivalent Rigid Link System approach is considered from an experimental validation perspective. A dynamic simulator implementing the formulation is used and an experimental test-bench is set-up. Experimental tests are carried out with a benchmark L-shape mechanism.

  10. Experimental Validation of a Wave Energy Converter Array Hydrodynamics Tool

    DEFF Research Database (Denmark)

    Ruiz, Pau Mercadé; Ferri, Francesco; Kofoed, Jens Peter

    2017-01-01

    This paper uses experimental data to validate a wave energy converter (WEC) array hydrodynamics tool developed within the context of linearized potential flow theory. To this end, wave forces and power absorption by an array of five-point absorber WECs in monochromatic and panchromatic waves were...... measured from a set of deep-water wave basin experimental tests. Unlike the few other examples of WEC array experimental campaigns, the power take-off (PTO) system of each WEC was simulated by means of advanced equipment capable of accurately reproducing linear control strategies and, thereby, reducing......, wave forces and power absorption with less than 17.5% and 23.0% error, respectively, for more than 68% of the predictions....

  11. Experimental validation of mathematical model for small air compressor

    Directory of Open Access Journals (Sweden)

    Tuhovčák Ján

    2017-01-01

    Full Text Available Development process of reciprocating compressors can be simplified by using simulation tools. Modelling of a compressor requires a trade-off between computational effort and accuracy of desired results. This paper presents experimental validation of the simulation tool, which can be used to predict compressor behaviour under different working conditions. The mathematical model provides fast results with very good accuracy, however the model must be calibrated for a certain type of compressor. Small air compressor was used to validate an in-house simulation tool, which is based on mass and energy conservation in a control volume. The simulation tool calculates pressure and temperature history inside the cylinder, valve characteristics, mass flow and heat losses during the cycle of the compressor. A test bench for the compressor consisted of pressure sensors on both discharge and suction side, temperature sensor on discharge side and flow meter with calorimetric principle sensor.

  12. Topology Optimization for Wave Propagation Problems with Experimental Validation

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk

    from acoustics, however problems for TE or TM polarized electromagnetic waves and shear waves in solids in two dimensions may be treated using the proposed methods with minor modifications. A brief introduction to wave problems and to density-based topology optimizationis included, as is a brief......This Thesis treats the development and experimental validation of density-based topology optimization methods for wave propagation problems. Problems in the frequency regime where design dimensions are between approximately one fourth and ten wavelengths are considered. All examples treat problems...

  13. Dynamic Modeling of Wind Turbine Gearboxes and Experimental Validation

    DEFF Research Database (Denmark)

    Pedersen, Rune

    is presented. The model takes into account the effects of load and applied grinding corrections. The results are verified by comparing to simulated and experimental results reported in the existing literature. Using gear data loosely based on a 1 MW wind turbine gearbox, the gear mesh stiffness is expanded...... analysis in relation to gear dynamics. A multibody model of two complete 2.3MWwind turbine gearboxes mounted back-to-back in a test rig is built. The mean values of the proposed gear mesh stiffnesses are included. The model is validated by comparing with calculated and measured eigenfrequencies and mode...

  14. Injection Moulding Simulation and Experimental Validation of Hearing Aid Shells

    DEFF Research Database (Denmark)

    Islam, Aminul; Li, Xiaoliu

    ) mode was adopted in this work to simulate the injection molding process of a hearing aid shell made of Polybutylene Terephthalate (PBT) filled with 30% glass fiber. The typical hearing aid shells are complex thin-walled structures made by injection molding. Highly sophisticated molds and lots...... of process optimizations by trial and errors are needed to make successful shells for hearing aids. In this context, a dedicated simulation tool can be very useful to reduce the time and cost for developing the new hearing aids. In this work, the injection molding experimental validation of the Moldex3D...

  15. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2014-04-01

    This project (10/01/2010-9/30/2014), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. In this project, the focus is to develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments.

  16. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2012-10-01

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This project will directly support the technical goals specified in DEFOA- 0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop and implement novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; perform material characterizations and oxidation/corrosion tests; and demonstrate our new thermal barrier coating (TBC) systems experimentally under integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed Durability Test Rig.

  17. Thermal conductivity of microporous layers: Analytical modeling and experimental validation

    Science.gov (United States)

    Andisheh-Tadbir, Mehdi; Kjeang, Erik; Bahrami, Majid

    2015-11-01

    A new compact relationship is developed for the thermal conductivity of the microporous layer (MPL) used in polymer electrolyte fuel cells as a function of pore size distribution, porosity, and compression pressure. The proposed model is successfully validated against experimental data obtained from a transient plane source thermal constants analyzer. The thermal conductivities of carbon paper samples with and without MPL were measured as a function of load (1-6 bars) and the MPL thermal conductivity was found between 0.13 and 0.17 W m-1 K-1. The proposed analytical model predicts the experimental thermal conductivities within 5%. A correlation generated from the analytical model was used in a multi objective genetic algorithm to predict the pore size distribution and porosity for an MPL with optimized thermal conductivity and mass diffusivity. The results suggest that an optimized MPL, in terms of heat and mass transfer coefficients, has an average pore size of 122 nm and 63% porosity.

  18. Experimental validation of the multiphase extended Leblond's model

    Science.gov (United States)

    Weisz-Patrault, Daniel

    2017-10-01

    Transformation induced plasticity is a crucial contribution of the simulation of several forming processes involving phase transitions under mechanical loads, resulting in large irreversible strain even though the applied stress is under the yield stress. One of the most elegant and widely used models is based on analytic homogenization procedures and has been proposed by Leblond et al. [1-4]. Very recently, a simple extension of the Leblond's model has been developed by Weisz-Patrault [8]. Several product phases are taken into account and several assumptions are relaxed in order to extend the applicability of the model. The present contribution compares experimental tests with numerical computations, in order to discuss the validity of the developed theory. Thus, experimental results extracted from the existing literature are analyzed. Results show a good agreement between measurements and theoretical computations.

  19. Theoretical And Experimental Validation Of Bike Chassis For Weight Reduction

    Directory of Open Access Journals (Sweden)

    Pavana Shireesha Paningipalli

    2015-08-01

    Full Text Available It is important to recognize that the design of any machine is an interdisciplinary process involving aerodynamics thermodynamics fluid dynamics stress analysis vibration analysis the selection of materials and the requirements for manufacturing. The operation of any mechanical system will always produce some vibration. Our goal is to minimize the effect of these vibrations because while it is undesirable vibration is unavoidable. The result of excess vibration can vary from nuisance disturbance to a catastrophic failure. Bike chassis is a major component in a vehicle system. This work involves vibration analysis to determine the key characteristics of a bike chassis. The dynamic characteristics of bike chassis such as the natural frequency and mode shape were determined by using finite element FE method. Al material will replace the conventional MS material. Experimental modal analysis was carried out to validate the FE models. Predicted natural frequency and mode shape were validated against the experimental results. Finally the modification of the updated FE bike chassis model was proposed to reduce the vibration improve the strength and optimize the weight of the bike chassis. Tools used are catiaV5 for 3D modelling Hypermesh for meshing and Ansys for post processing.

  20. Experimental validation of solid rocket motor damping models

    Science.gov (United States)

    Riso, Cristina; Fransen, Sebastiaan; Mastroddi, Franco; Coppotelli, Giuliano; Trequattrini, Francesco; De Vivo, Alessio

    2017-12-01

    In design and certification of spacecraft, payload/launcher coupled load analyses are performed to simulate the satellite dynamic environment. To obtain accurate predictions, the system damping properties must be properly taken into account in the finite element model used for coupled load analysis. This is typically done using a structural damping characterization in the frequency domain, which is not applicable in the time domain. Therefore, the structural damping matrix of the system must be converted into an equivalent viscous damping matrix when a transient coupled load analysis is performed. This paper focuses on the validation of equivalent viscous damping methods for dynamically condensed finite element models via correlation with experimental data for a realistic structure representative of a slender launch vehicle with solid rocket motors. A second scope of the paper is to investigate how to conveniently choose a single combination of Young's modulus and structural damping coefficient—complex Young's modulus—to approximate the viscoelastic behavior of a solid propellant material in the frequency band of interest for coupled load analysis. A scaled-down test article inspired to the Z9-ignition Vega launcher configuration is designed, manufactured, and experimentally tested to obtain data for validation of the equivalent viscous damping methods. The Z9-like component of the test article is filled with a viscoelastic material representative of the Z9 solid propellant that is also preliminarily tested to investigate the dependency of the complex Young's modulus on the excitation frequency and provide data for the test article finite element model. Experimental results from seismic and shock tests performed on the test configuration are correlated with numerical results from frequency and time domain analyses carried out on its dynamically condensed finite element model to assess the applicability of different equivalent viscous damping methods to describe

  1. CFD Modeling and Experimental Validation of a Solar Still

    Directory of Open Access Journals (Sweden)

    Mahmood Tahir

    2017-01-01

    Full Text Available Earth is the densest planet of the solar system with total area of 510.072 million square Km. Over 71.68% of this area is covered with water leaving a scant area of 28.32% for human to inhabit. The fresh water accounts for only 2.5% of the total volume and the rest is the brackish water. Presently, the world is facing chief problem of lack of potable water. This issue can be addressed by converting brackish water into potable through a solar distillation process and solar still is specially assigned for this purpose. Efficiency of a solar still explicitly depends on its design parameters, such as wall material, chamber depth, width and slope of the zcondensing surface. This study was aimed at investigating the solar still parameters using CFD modeling and experimental validation. The simulation data of ANSYS-FLUENT was compared with actual experimental data. A close agreement among the simulated and experimental results was seen in the presented work. It reveals that ANSYS-FLUENT is a potent tool to analyse the efficiency of the new designs of the solar distillation systems.

  2. Method for Determining Volumetric Efficiency and Its Experimental Validation

    Directory of Open Access Journals (Sweden)

    Ambrozik Andrzej

    2017-12-01

    Full Text Available Modern means of transport are basically powered by piston internal combustion engines. Increasingly rigorous demands are placed on IC engines in order to minimise the detrimental impact they have on the natural environment. That stimulates the development of research on piston internal combustion engines. The research involves experimental and theoretical investigations carried out using computer technologies. While being filled, the cylinder is considered to be an open thermodynamic system, in which non-stationary processes occur. To make calculations of thermodynamic parameters of the engine operating cycle, based on the comparison of cycles, it is necessary to know the mean constant value of cylinder pressure throughout this process. Because of the character of in-cylinder pressure pattern and difficulties in pressure experimental determination, in the present paper, a novel method for the determination of this quantity was presented. In the new approach, the iteration method was used. In the method developed for determining the volumetric efficiency, the following equations were employed: the law of conservation of the amount of substance, the first law of thermodynamics for open system, dependences for changes in the cylinder volume vs. the crankshaft rotation angle, and the state equation. The results of calculations performed with this method were validated by means of experimental investigations carried out for a selected engine at the engine test bench. A satisfactory congruence of computational and experimental results as regards determining the volumetric efficiency was obtained. The method for determining the volumetric efficiency presented in the paper can be used to investigate the processes taking place in the cylinder of an IC engine.

  3. Students' epistemologies about experimental physics: Validating the Colorado Learning Attitudes about Science Survey for Experimental Physics

    CERN Document Server

    Wilcox, Bethany R

    2015-01-01

    Student learning in instructional physics labs represents a growing area of research that includes investigations of students' beliefs and expectations about the nature of experimental physics. To directly probe students' epistemologies about experimental physics and support broader lab transformation efforts at the University of Colorado Boulder (CU) and elsewhere, we developed the Colorado Learning Attitudes about Science Survey for Experimental Physics (E-CLASS). Previous work with this assessment has included establishing the accuracy and clarity of the instrument through student interviews and preliminary testing. Several years of data collection at multiple institutions has resulted in a growing national data set of student responses. Here, we report on results of the analysis of these data to investigate the statistical validity and reliability of the E-CLASS as a measure of students' epistemologies for a broad student population. We find that the E-CLASS demonstrates an acceptable level of both validi...

  4. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  5. Neuroinflammatory targets and treatments for epilepsy validated in experimental models.

    Science.gov (United States)

    Aronica, Eleonora; Bauer, Sebastian; Bozzi, Yuri; Caleo, Matteo; Dingledine, Raymond; Gorter, Jan A; Henshall, David C; Kaufer, Daniela; Koh, Sookyong; Löscher, Wolfgang; Louboutin, Jean-Pierre; Mishto, Michele; Norwood, Braxton A; Palma, Eleonora; Poulter, Michael O; Terrone, Gaetano; Vezzani, Annamaria; Kaminski, Rafal M

    2017-07-01

    A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy. Specific inflammatory molecules and pathways have been identified that influence various pathologic outcomes in different experimental models of epilepsy. Most importantly, the same inflammatory pathways have also been found in surgically resected brain tissue from patients with treatment-resistant epilepsy. New antiseizure therapies may be derived from these novel potential targets. An essential and crucial question is whether targeting these molecules and pathways may result in anti-ictogenesis, antiepileptogenesis, and/or disease-modification effects. Therefore, preclinical testing in models mimicking relevant aspects of epileptogenesis is needed to guide integrated experimental and clinical trial designs. We discuss the most recent preclinical proof-of-concept studies validating a number of therapeutic approaches against inflammatory mechanisms in animal models that could represent novel avenues for drug development in epilepsy. Finally, we suggest future directions to accelerate preclinical to clinical translation of these recent discoveries. Wiley Periodicals, Inc. © 2017 International League Against Epilepsy.

  6. Experimental validation of beam quality correction factors for proton beams.

    Science.gov (United States)

    Gomà, Carles; Hofstetter-Boillat, Bénédicte; Safai, Sairos; Vörös, Sándor

    2015-04-21

    This paper presents a method to experimentally validate the beam quality correction factors (kQ) tabulated in IAEA TRS-398 for proton beams and to determine the kQ of non-tabulated ionization chambers (based on the already tabulated values). The method is based exclusively on ionometry and it consists in comparing the reading of two ionization chambers under the same reference conditions in a proton beam quality Q and a reference beam quality (60)Co. This allows one to experimentally determine the ratio between the kQ of the two ionization chambers. In this work, 7 different ionization chamber models were irradiated under the IAEA TRS-398 reference conditions for (60)Co beams and proton beams. For the latter, the reference conditions for both modulated beams (spread-out Bragg peak field) and monoenergetic beams (pseudo-monoenergetic field) were studied. For monoenergetic beams, it was found that the experimental kQ values obtained for plane-parallel chambers are consistent with the values tabulated in IAEA TRS-398; whereas the kQ values obtained for cylindrical chambers are not consistent--being higher than the tabulated values. These results support the suggestion (of previous publications) that the IAEA TRS-398 reference conditions for monoenergetic proton beams should be revised so that the effective point of measurement of cylindrical ionization chambers is taken into account when positioning the reference point of the chamber at the reference depth. For modulated proton beams, the tabulated kQ values of all the ionization chambers studied in this work were found to be consistent with each other--except for the IBA FC65-G, whose experimental kQ value was found to be 0.6% lower than the tabulated one. The kQ of the PTW Advanced Markus chamber, which is not tabulated in IAEA TRS-398, was found to be 0.997 ± 0.042 (k = 2), based on the tabulated value of the PTW Markus chamber.

  7. Experimental validation of model Hortel Whillier; Validacion experimental del model de Hottel-Whillier

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez Munoz, F.; Cejudo Lopez, J. M.; Carrillo andres, A.

    2010-07-01

    Comparing the results of testing of a commercial flat-plate solar collector with a detailed implementation model of Hottel Whillier fin and tube. The validation procedure is based on comparing experimental and theoretical curves and more likely uncertainty bands. the model correctly predicts the end of profits and underestimates the 5% of losses, although a sensitivity analysis shows that this result is not attributable to the model itself but to the inputs with which it was implemented. The model has difficulty differentiating between the terms of linear and quadratic losses that appear in the quadratic fit curve. (Author) 1 refs.

  8. Experimental validation of Swy-2 clay standard's PHREEQC model

    Science.gov (United States)

    Szabó, Zsuzsanna; Hegyfalvi, Csaba; Freiler, Ágnes; Udvardi, Beatrix; Kónya, Péter; Székely, Edit; Falus, György

    2017-04-01

    One of the challenges of the present century is to limit the greenhouse gas emissions for the mitigation of climate change which is possible for example by a transitional technology, CCS (Carbon Capture and Storage) and, among others, by the increase of nuclear proportion in the energy mix. Clay minerals are considered to be responsible for the low permeability and sealing capacity of caprocks sealing off stored CO2 and they are also the main constituents of bentonite in high level radioactive waste disposal facilities. The understanding of clay behaviour in these deep geological environments is possible through laboratory batch experiments of well-known standards and coupled geochemical models. Such experimentally validated models are scarce even though they allow deriving more precise long-term predictions of mineral reactions and rock and bentonite degradation underground and, therefore, ensuring the safety of the above technologies and increase their public acceptance. This ongoing work aims to create a kinetic geochemical model of Na-montmorillonite standard Swy-2 in the widely used PHREEQC code, supported by solution and mineral composition results from batch experiments. Several four days experiments have been carried out in 1:35 rock:water ratio at atmospheric conditions, and with inert and CO2 supercritical phase at 100 bar and 80 ⁰C relevant for the potential Hungarian CO2 reservoir complex. Solution samples have been taken during and after experiments and their compositions were measured by ICP-OES. The treated solid phase has been analysed by XRD and ATR-FTIR and compared to in-parallel measured references (dried Swy-2). Kinetic geochemical modelling of the experimental conditions has been performed by PHREEQC version 3 using equations and kinetic rate parameters from the USGS report of Palandri and Kharaka (2004). The visualization of experimental and numerous modelling results has been automatized by R. Experiments and models show very fast

  9. Development of three multiplex PCR primer sets for ark shell ( Scapharca broughtonii) and their validation in parentage assignment

    Science.gov (United States)

    Li, Ning; Li, Qi; Kong, Lingfeng; Yu, Hong

    2016-04-01

    Scapharca broughtonii is a commercially important and over-exploited species. In order to investigate its genetic diversity and population structure, 43 novel polymorphic microsatellites were isolated and characterized. The number of alleles per locus ranged from 3 to 22 with an average of 6.93, and the observed and expected heterozygosities varied between 0.233 and 1.000, and 0.250 and 0.953, with an average of 0.614 and 0.707, respectively. Three highly informative multiplex PCRs were developed from nine of those microsatellites for S. broughtonii. We evaluated and validated these multiplex PCRs in 8 full-sib families. The average polymorphism information content (PIC) was 0.539. The frequency of null alleles was estimated as 3.13% of all the alleles segregation based on a within-family analysis of Mendelian segregation patterns. Parentage analysis of real offspring demonstrated that 100% of all offspring were unambiguously allocated to a pair of parents based on 3 multiplex sets. Those 43 microsatellite loci with high variability will be helpful for the analysis of population genetics and conservation of wild stock of S. broughtonii. The 3 sets of multiplex PCRs could be an important tool of pedigree reconstruction, population genetic analysis and brood stock management.

  10. Optimization and experimental validation of electrostatic adhesive geometry

    Science.gov (United States)

    Ruffatto, D.; Shah, J.; Spenko, M.

    This paper introduces a method to optimize the electrode geometry of electrostatic adhesives for robotic gripping, attachment, and manipulation applications. Electrostatic adhesion is achieved by applying a high voltage potential, on the order of kV, to a set of electrodes, which generates an electric field. The electric field polarizes the substrate material and creates an adhesion force. Previous attempts at creating electro-static adhesives have shown them to be effective, but researchers have made no effort to optimize the electrode configuration and geometry. We have shown that by optimizing the geometry of the electrode configuration, the electric field strength, and therefore the adhesion force, is enhanced. To accomplish this, Comsol Multiphysics was utilized to evaluate the average electric field generated by a given electrode geometry. Several electrode patterns were evaluated, including parallel conductors, concentric circles, Hilbert curves (a fractal geometry) and spirals. The arrangement of the electrodes in concentric circles with varying electrode widths proved to be the most effective. The most effective sizing was to use the smallest gap spacing allowable coupled with a variable electrode width. These results were experimentally validated on several different surfaces including drywall, wood, tile, glass, and steel. A new manufacturing process allowing for the fabrication of thin, conformal electro-static adhesive pads was utilized. By combining the optimized electrode geometry with the new fabrication process we are able to demonstrate a marked improvement of up to 500% in shear pressure when compared to previously published values.

  11. Integral Reactor Containment Condensation Model and Experimental Validation

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Qiao [Oregon State Univ., Corvallis, OR (United States); Corradini, Michael [Univ. of Wisconsin, Madison, WI (United States)

    2016-05-02

    This NEUP funded project, NEUP 12-3630, is for experimental, numerical and analytical studies on high-pressure steam condensation phenomena in a steel containment vessel connected to a water cooling tank, carried out at Oregon State University (OrSU) and the University of Wisconsin at Madison (UW-Madison). In the three years of investigation duration, following the original proposal, the planned tasks have been completed: (1) Performed a scaling study for the full pressure test facility applicable to the reference design for the condensation heat transfer process during design basis accidents (DBAs), modified the existing test facility to route the steady-state secondary steam flow into the high pressure containment for controllable condensation tests, and extended the operations at negative gage pressure conditions (OrSU). (2) Conducted a series of DBA and quasi-steady experiments using the full pressure test facility to provide a reliable high pressure condensation database (OrSU). (3) Analyzed experimental data and evaluated condensation model for the experimental conditions, and predicted the prototypic containment performance under accidental conditions (UW-Madison). A film flow model was developed for the scaling analysis, and the results suggest that the 1/3 scaled test facility covers large portion of laminar film flow, leading to a lower average heat transfer coefficient comparing to the prototypic value. Although it is conservative in reactor safety analysis, the significant reduction of heat transfer coefficient (50%) could under estimate the prototypic condensation heat transfer rate, resulting in inaccurate prediction of the decay heat removal capability. Further investigation is thus needed to quantify the scaling distortion for safety analysis code validation. Experimental investigations were performed in the existing MASLWR test facility at OrST with minor modifications. A total of 13 containment condensation tests were conducted for pressure

  12. GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

    Science.gov (United States)

    Gubelmann, Carine; Gattiker, Alexandre; Massouras, Andreas; Hens, Korneel; David, Fabrice; Decouttere, Frederik; Rougemont, Jacques; Deplancke, Bart

    2011-01-01

    The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and patterns of these variants with high sensitivity. High-throughput quantitative real-time polymerase chain reaction (qPCR) is an ideal technique to accurately quantify nucleic acid sequences including splice variants. However, currently available primer design programs do not distinguish between splice variants and also differ substantially in overall quality, functionality or throughput mode. Here, we present GETPrime, a primer database supported by a novel platform that uniquely combines and automates several features critical for optimal qPCR primer design. These include the consideration of all gene splice variants to enable either gene-specific (covering the majority of splice variants) or transcript-specific (covering one splice variant) expression profiling, primer specificity validation, automated best primer pair selection according to strict criteria and graphical visualization of the latter primer pairs within their genomic context. GETPrime primers have been extensively validated experimentally, demonstrating high transcript specificity in complex samples. Thus, the free-access, user-friendly GETPrime database allows fast primer retrieval and visualization for genes or groups of genes of most common model organisms, and is available at http://updepla1srv1.epfl.ch/getprime/. Database URL: http://deplanckelab.epfl.ch. PMID:21917859

  13. RUCS: rapid identification of PCR primers for unique core sequences.

    Science.gov (United States)

    Thomsen, Martin Christen Frølund; Hasman, Henrik; Westh, Henrik; Kaya, Hülya; Lund, Ole

    2017-12-15

    Designing PCR primers to target a specific selection of whole genome sequenced strains can be a long, arduous and sometimes impractical task. Such tasks would benefit greatly from an automated tool to both identify unique targets, and to validate the vast number of potential primer pairs for the targets in silico. Here we present RUCS, a program that will find PCR primer pairs and probes for the unique core sequences of a positive genome dataset complement to a negative genome dataset. The resulting primer pairs and probes are in addition to simple selection also validated through a complex in silico PCR simulation. We compared our method, which identifies the unique core sequences, against an existing tool called ssGeneFinder, and found that our method was 6.5-20 times more sensitive. We used RUCS to design primer pairs that would target a set of genomes known to contain the mcr-1 colistin resistance gene. Three of the predicted pairs were chosen for experimental validation using PCR and gel electrophoresis. All three pairs successfully produced an amplicon with the target length for the samples containing mcr-1 and no amplification products were produced for the negative samples. The novel methods presented in this manuscript can reduce the time needed to identify target sequences, and provide a quick virtual PCR validation to eliminate time wasted on ambiguously binding primers. Source code is freely available on https://bitbucket.org/genomicepidemiology/rucs. Web service is freely available on https://cge.cbs.dtu.dk/services/RUCS. mcft@cbs.dtu.dk. Supplementary data are available at Bioinformatics online.

  14. Towards experimental validation of an analysis framework for morphing radiators

    Science.gov (United States)

    Bertagne, Christopher L.; Erickson, Lisa R.; Sheth, Rubik B.; Whitcomb, John D.; Hartl, Darren J.

    2016-04-01

    Thermal control is an important aspect of spacecraft design, particularly in the case of crewed vehicles, which must maintain a precise internal temperature at all times in spite of sometimes drastic variations in the external thermal environment and internal heat loads. The successes of the Space Shuttle and International Space Station programs have shown that this can be accomplished in Low Earth Orbit (LEO), however, crewed spacecraft traveling beyond LEO are expected to encounter more challenging thermal conditions with significant variations in both the heat rejection requirements and environment temperature. Such missions will require radiator systems with high turndown ratios, defined as the ratio between the maximum and minimum heat rejection rates achievable by the radiator system. Current radiators are only able to achieve turndown ratios of 3:1, far less than the 12:1 turndown ratio which is expected to be required on future missions. An innovative radiator concept, known as a morphing radiator, uses the temperature-induced shape change of shape memory alloy (SMA) materials to achieve a turndown ratio of at least 12:1. Predicting the thermal and structural behavior of SMA-based morphing radiators is challenging due to the presence of two-way thermomechanical coupling that has not been widely considered in the literature. Previous work has demonstrated the application of a technique known as a partitioned analysis procedure which can be used to simulate the behavior of morphing radiators. This work describes ongoing efforts to evaluate the physical accuracy of this approach by conducting validation studies. A detailed finite element model of a morphing radiator is developed and executed using the framework. Preliminary results show close agreement between the experimental data and model predictions, giving additional confidence in the partitioned approach.

  15. UniPrimer: A Web-Based Primer Design Tool for Comparative Analyses of Primate Genomes

    Directory of Open Access Journals (Sweden)

    Nomin Batnyam

    2012-01-01

    Full Text Available Whole genome sequences of various primates have been released due to advanced DNA-sequencing technology. A combination of computational data mining and the polymerase chain reaction (PCR assay to validate the data is an excellent method for conducting comparative genomics. Thus, designing primers for PCR is an essential procedure for a comparative analysis of primate genomes. Here, we developed and introduced UniPrimer for use in those studies. UniPrimer is a web-based tool that designs PCR- and DNA-sequencing primers. It compares the sequences from six different primates (human, chimpanzee, gorilla, orangutan, gibbon, and rhesus macaque and designs primers on the conserved region across species. UniPrimer is linked to RepeatMasker, Primer3Plus, and OligoCalc softwares to produce primers with high accuracy and UCSC In-Silico PCR to confirm whether the designed primers work. To test the performance of UniPrimer, we designed primers on sample sequences using UniPrimer and manually designed primers for the same sequences. The comparison of the two processes showed that UniPrimer was more effective than manual work in terms of saving time and reducing errors.

  16. Experimental Validation of Flow Force Models for Fast Switching Valves

    DEFF Research Database (Denmark)

    Bender, Niels Christian; Pedersen, Henrik Clemmensen; Nørgård, Christian

    2017-01-01

    to compare and validate different models, where an effort is directed towards capturing the fluid squeeze effect just before material on material contact. The test data is compared with simulation data relying solely on analytic formulations. The general dynamics of the plunger is validated...

  17. Design and experimental application of a novel non-degenerate universal primer set that amplifies prokaryotic 16S rRNA genes with a low possibility to amplify eukaryotic rRNA genes.

    Science.gov (United States)

    Mori, Hiroshi; Maruyama, Fumito; Kato, Hiromi; Toyoda, Atsushi; Dozono, Ayumi; Ohtsubo, Yoshiyuki; Nagata, Yuji; Fujiyama, Asao; Tsuda, Masataka; Kurokawa, Ken

    2014-01-01

    The deep sequencing of 16S rRNA genes amplified by universal primers has revolutionized our understanding of microbial communities by allowing the characterization of the diversity of the uncultured majority. However, some universal primers also amplify eukaryotic rRNA genes, leading to a decrease in the efficiency of sequencing of prokaryotic 16S rRNA genes with possible mischaracterization of the diversity in the microbial community. In this study, we compared 16S rRNA gene sequences from genome-sequenced strains and identified candidates for non-degenerate universal primers that could be used for the amplification of prokaryotic 16S rRNA genes. The 50 identified candidates were investigated to calculate their coverage for prokaryotic and eukaryotic rRNA genes, including those from uncultured taxa and eukaryotic organelles, and a novel universal primer set, 342F-806R, covering many prokaryotic, but not eukaryotic, rRNA genes was identified. This primer set was validated by the amplification of 16S rRNA genes from a soil metagenomic sample and subsequent pyrosequencing using the Roche 454 platform. The same sample was also used for pyrosequencing of the amplicons by employing a commonly used primer set, 338F-533R, and for shotgun metagenomic sequencing using the Illumina platform. Our comparison of the taxonomic compositions inferred by the three sequencing experiments indicated that the non-degenerate 342F-806R primer set can characterize the taxonomic composition of the microbial community without substantial bias, and is highly expected to be applicable to the analysis of a wide variety of microbial communities.

  18. Development and experimental validation of a predictive threshold cycle equation for quantification of virulence and marker genes by high-throughput nanoliter-volume PCR on the OpenArray platform.

    Science.gov (United States)

    Stedtfeld, Robert D; Baushke, Samuel W; Tourlousse, Dieter M; Miller, Sarah M; Stedtfeld, Tiffany M; Gulari, Erdogan; Tiedje, James M; Hashsham, Syed A

    2008-06-01

    Development of quantitative PCR (QPCR) assays typically requires extensive screening within and across a given species to ensure specific detection and lucid identification among various pathogenic and nonpathogenic strains and to generate standard curves. To minimize screening requirements, multiple virulence and marker genes (VMGs) were targeted simultaneously to enhance reliability, and a predictive threshold cycle (C(T)) equation was developed to calculate the number of starting copies based on an experimental C(T). The empirical equation was developed with Sybr green detection in nanoliter-volume QPCR chambers (OpenArray) and tested with 220 previously unvalidated primer pairs targeting 200 VMGs from 30 pathogens. A high correlation (R(2) = 0.816) was observed between the predicted and experimental C(T)s based on the organism's genome size, guanine and cytosine (GC) content, amplicon length, and stability of the primer's 3' end. The performance of the predictive C(T) equation was tested using 36 validation samples consisting of pathogenic organisms spiked into genomic DNA extracted from three environmental waters. In addition, the primer success rate was dependent on the GC content of the target organisms and primer sequences. Targeting multiple assays per organism and using the predictive C(T) equation are expected to reduce the extent of the validation necessary when developing QPCR arrays for a large number of pathogens or other targets.

  19. Experimental Aspects of Code Validation in Hypersonic Flows

    Science.gov (United States)

    Chanetz, Bruno; Délery, Jean

    2005-05-01

    In spite of the spectacular progress in CFD there is still a strong need to validate the computer codes by comparison with experiments. The first validation step is the assessment of the code numerical safety and the physical models accuracy. This validation step requires carefully made building block experiments. To be calculable, such experiments must satisfy conditions such as the precise definition of the test set-up geometry, the absence of uncontrolled parasitic effects, a complete information on the flow conditions and indication on the uncertainty margins. Under these conditions, the experiment can be put into a data bank which will be precious to help in the development of reliable and accurate codes. The paper provides an overview of modern measurement techniques for hypersonic flows analysis. The demonstration is illustrated by laminar experiments used to assess the numerical accuracy of codes run in high Mach number flows.

  20. Development and validation of a new PCR optimization method by combining experimental design and artificial neural network.

    Science.gov (United States)

    Li, Ye; Du, Xueling; Yuan, Qipeng; Lv, Xinhua

    2010-01-01

    Polymerase chain reaction (PCR) is one of the most powerful techniques in a variety of clinical and biological research fields. In this paper, a chemometrics approach, combining experimental design (ED) and artificial neural network (ANN), was proposed for optimization of PCR amplification of lycopene cyclase gene carRA in Blakeslea Trispora. Five-level star design was carried out to obtain experimental information and provide data source for ANN modeling. Nine variables were used as inputs in ANN, including the added amount of template, primer, dNTP, polymerase and magnesium ion, the temperature of denaturating, annealing and extension, and the number of cycles. The output variable was the efficiency (yield) of the PCR. Based on the developed model, the effects of each parameter on PCR efficiency were predicted and the most suitable operation condition for present system was determined. At last, the validation experiment was performed under the optimized condition, and the expectant results were produced. The results obtained in this paper showed that the combination of ANN and ED provided a satisfactory optimization model with good descriptive and predictive abilities, indicating that the method of combining ANN and ED can be a useful tool in PCR optimization and other biological applications.

  1. Experimental Analysis and Model Validation of an Opaque Ventilated Facade

    DEFF Research Database (Denmark)

    López, F. Peci; Jensen, Rasmus Lund; Heiselberg, Per

    2012-01-01

    Natural ventilation is a convenient way of reducing energy consumption in buildings. In this study an experimental module of an opaque ventilated façade (OVF) was built and tested for assessing its potential of supplying free ventilation and air preheating for the building. A numerical model was ...

  2. Melt pool modelling, simulation and experimental validation for SLM

    NARCIS (Netherlands)

    Wits, Wessel

    2017-01-01

    SLM parts are built by successively melting layers of powder in a powder bed. Process parameters are often optimized experimentally by laser scanning a number of single tracks and subsequently determining which settings lead to a good compromise between quality and build speed. However,

  3. Experimental validation of numerical sensitivities in a deep drawing simulation

    NARCIS (Netherlands)

    van den Boogaard, Antonius H.; Carleer, B.D.; Atzema, E.H.; ter Wijlen, E.V.

    2008-01-01

    Deep drawing of a benchmark B-pillar is numerically modelled and experimentally performed with varying blankholder force and several blank shape parameters. The most influential parameters are selected for optimisation. Direct application of Autoform sigma software was used to determine

  4. Heat Transfer Simulation for Reciprocating Compressor with Experimental Validation

    Science.gov (United States)

    Zhou, Ruixin; Guo, Bei; Chen, Xiaole; Tuo, Jinliang; Wu, Rui; Fagotti, Fabian; Zhao, Yali; Yang, Song; Xu, Bo

    2017-08-01

    The efficiency of reciprocating compressor can be influenced by heat transfer and the reliability can be also affected by the temperature distribution in compressor. In consideration of the complex relationship of heat transfer, the compressor is divided into six control volumes including the suction muffler, the cylinder, the discharge chamber, the discharge muffler, the discharge line and the compressor shell. The steady state energy balance equations of the open system for each control volume are built up after the crankshaft rotates one cycle. The heat flux of the cylinder is calculated by the existing correlation. The heat transfer coefficient correlations in energy equations are chosen in references and revised by experimental results. Three same type reciprocating compressors used in R290 system installed with themocouples are tested under some planed conditions in order to ensure accuracy. The simulation results are compared with the experimental results. It shows that the simplified method presented in this paper is effective.

  5. DMFC anode polarization: Experimental analysis and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, A.; Marchesi, R. [Dipartimento di Energetica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2008-01-03

    Anode two-phase flow has an important influence on DMFC performance and methanol crossover. In order to elucidate two-phase flow influence on anode performance, in this work, anode polarization is investigated combining experimental and modelling approach. A systematic experimental analysis of operating conditions influence on anode polarization is presented. Hysteresis due to operating condition is observed; experimental results suggest that it arises from methanol accumulation and has to be considered in evaluating DMFC performances and measurements reproducibility. A model of DMFC anode polarization is presented and utilised as tool to investigate anode two-phase flow. The proposed analysis permits one to produce a confident interpretation of the main involved phenomena. In particular, it confirms that methanol electro-oxidation kinetics is weakly dependent on methanol concentration and that methanol transport in gas phase produces an important contribution in anode feeding. Moreover, it emphasises the possibility to optimise anode flow rate in order to improve DMFC performance and reduce methanol crossover. (author)

  6. Solar power plant performance evaluation: simulation and experimental validation

    Science.gov (United States)

    Natsheh, E. M.; Albarbar, A.

    2012-05-01

    In this work the performance of solar power plant is evaluated based on a developed model comprise photovoltaic array, battery storage, controller and converters. The model is implemented using MATLAB/SIMULINK software package. Perturb and observe (P&O) algorithm is used for maximizing the generated power based on maximum power point tracker (MPPT) implementation. The outcome of the developed model are validated and supported by a case study carried out using operational 28.8kW grid-connected solar power plant located in central Manchester. Measurements were taken over 21 month's period; using hourly average irradiance and cell temperature. It was found that system degradation could be clearly monitored by determining the residual (the difference) between the output power predicted by the model and the actual measured power parameters. It was found that the residual exceeded the healthy threshold, 1.7kW, due to heavy snow in Manchester last winter. More important, the developed performance evaluation technique could be adopted to detect any other reasons that may degrade the performance of the P V panels such as shading and dirt. Repeatability and reliability of the developed system performance were validated during this period. Good agreement was achieved between the theoretical simulation and the real time measurement taken the online grid connected solar power plant.

  7. Experimental validation of advanced explosive/metal interactions

    Science.gov (United States)

    Lambert, D. E.

    2005-08-01

    The extremely high power density stored in explosives drives their selection of use in military, mining, demolition, cladding, shock consolidation of powders, shock-induced chemical synthesis and magnetic flux compression processes. The use of distributed initiation locations has emerged as a primary method to customize the detonation front and create desirable output. Explosive/metal systems with multiple, distributed initiation locations create detonation states that do not follow the simple line of sight, or Huygens model and, hence, advanced detonation physics with associated theory are required. The theory of detonation shock dynamics (DSD) is one such description used to provide high fidelity modeling of complex wave structures. A collection of experiments using simultaneous ultra-high speed digital framing and streak film cameras is presented as a means of obtaining spatial and temporal characteristics of complex detonation fronts that validate the DSD descriptions. The method of test, operational conditions and results are given to demonstrate the use of high rate imaging of detonation events and how this validates our understanding of the physics and the capability of advanced detonation wave tracking models.

  8. The turbulent viscosity models and their experimental validation; Les modeles de viscosite turbulente et leur validation experimentale

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    This workshop on turbulent viscosity models and on their experimental validation was organized by the `convection` section of the French society of thermal engineers. From the 9 papers presented during this workshop, 8 deal with the modeling of turbulent flows inside combustion chambers, turbo-machineries or in other energy-related applications, and have been selected for ETDE. (J.S.)

  9. Evaluation model and experimental validation of tritium in agricultural plant

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Hee Suk; Keum, Dong Kwon; Lee, Han Soo; Jun, In; Choi, Yong Ho; Lee, Chang Woo [KAERI, Daejon (Korea, Republic of)

    2005-12-15

    This paper describes a compartment dynamic model for evaluating the contamination level of tritium in agricultural plants exposed by accidentally released tritium. The present model uses a time dependent growth equation of plant so that it can predict the effect of growth stage of plant during the exposure time. The model including atmosphere, soil and plant compartments is described by a set of nonlinear ordinary differential equations, and is able to predict time-dependent concentrations of tritium in the compartments. To validate the model, a series of exposure experiments of HTO vapor on Chinese cabbage and radish was carried out at the different growth stage of each plant. At the end of exposure, the tissue free water(TFWT) and the organically bound tritium (OBT) were measured. The measured concentrations were agreed well with model predictions.

  10. Numerical and Experimental Validation of a New Damage Initiation Criterion

    Science.gov (United States)

    Sadhinoch, M.; Atzema, E. H.; Perdahcioglu, E. S.; van den Boogaard, A. H.

    2017-09-01

    Most commercial finite element software packages, like Abaqus, have a built-in coupled damage model where a damage evolution needs to be defined in terms of a single fracture energy value for all stress states. The Johnson-Cook criterion has been modified to be Lode parameter dependent and this Modified Johnson-Cook (MJC) criterion is used as a Damage Initiation Surface (DIS) in combination with the built-in Abaqus ductile damage model. An exponential damage evolution law has been used with a single fracture energy value. Ultimately, the simulated force-displacement curves are compared with experiments to validate the MJC criterion. 7 out of 9 fracture experiments were predicted accurately. The limitations and accuracy of the failure predictions of the newly developed damage initiation criterion will be discussed shortly.

  11. Experimental validation of the electrokinetic theory and development of seismoelectric interferometry by cross-correlation

    NARCIS (Netherlands)

    Schoemaker, E.C.; Grobbe, N.; Schakel, M.D.; De Ridder, S.A.L.; Slob, E.C.; Smeulders, D.M.J.

    2012-01-01

    We experimentally validate a relatively recent electrokinetic formulation of the streaming potential (SP) coefficient as developed by Pride (1994). The start of our investigation focuses on the streaming potential coefficient, which gives rise to the coupling of mechanical and electromagnetic

  12. THE EXPERIMENTAL VALIDATION OF THE GROUNDING DEVICE RESISTANCE MEASUREMENT METHOD

    Directory of Open Access Journals (Sweden)

    I. V. Nizhevskyi

    2016-12-01

    Full Text Available Purpose. The paper considers experimental research of three-electrode units for measuring the resistance of grounding devices for different purposes. Methodology. The experimental study of the method of resistance measurement of grounding devices for any design in any soil structure using the method of physical modeling is presented. Results. By results of model operation the set of equations of the sixth order is solved. It allowed to determine the own and mutual impedance in the three-electrode unit with high accuracy without searching the point of zero potential. Features of measuring and defining the own and relative resistances of various combinations of electrodes for three-electrode measuring unit are considered. Originality. The necessity of finding a zero potential point is excluded. Practical value. The proposed method provides the smallest possible spacing of potential electrodes outside the grounding devices. This reduces the wiring length measurement circuit in several times, increases the ratio «signal – noise», removes the restrictions on building of the territory outside the test grounding device.

  13. Experimental validation of a Bayesian model of visual acuity.

    LENUS (Irish Health Repository)

    Dalimier, Eugénie

    2009-01-01

    Based on standard procedures used in optometry clinics, we compare measurements of visual acuity for 10 subjects (11 eyes tested) in the presence of natural ocular aberrations and different degrees of induced defocus, with the predictions given by a Bayesian model customized with aberrometric data of the eye. The absolute predictions of the model, without any adjustment, show good agreement with the experimental data, in terms of correlation and absolute error. The efficiency of the model is discussed in comparison with image quality metrics and other customized visual process models. An analysis of the importance and customization of each stage of the model is also given; it stresses the potential high predictive power from precise modeling of ocular and neural transfer functions.

  14. EXPERIMENTAL VALIDATION OF CUMULATIVE SURFACE LOCATION ERROR FOR TURNING PROCESSES

    Directory of Open Access Journals (Sweden)

    Adam K. Kiss

    2016-02-01

    Full Text Available The aim of this study is to create a mechanical model which is suitable to investigate the surface quality in turning processes, based on the Cumulative Surface Location Error (CSLE, which describes the series of the consecutive Surface Location Errors (SLE in roughing operations. In the established model, the investigated CSLE depends on the currently and the previously resulted SLE by means of the variation of the width of cut. The phenomenon of the system can be described as an implicit discrete map. The stationary Surface Location Error and its bifurcations were analysed and flip-type bifurcation was observed for CSLE. Experimental verification of the theoretical results was carried out.

  15. Radiative transfer model for contaminated slabs : experimental validations

    CERN Document Server

    Andrieu, François; Schmitt, Bernard; Douté, Sylvain; Brissaud, Olivier

    2015-01-01

    This article presents a set of spectro-goniometric measurements of different water ice samples and the comparison with an approximated radiative transfer model. The experiments were done using the spectro-radiogoniometer described in Brissaud et al. (2004). The radiative transfer model assumes an isotropization of the flux after the second interface and is fully described in Andrieu et al. (2015). Two kind of experiments were conducted. First, the specular spot was closely investigated, at high angular resolution, at the wavelength of $1.5\\,\\mbox{\\mu m}$, where ice behaves as a very absorbing media. Second, the bidirectional reflectance was sampled at various geometries, including low phase angles on 61 wavelengths ranging from $0.8\\,\\mbox{\\mu m}$ to $2.0\\,\\mbox{\\mu m}$. In order to validate the model, we made a qualitative test to demonstrate the relative isotropization of the flux. We also conducted quantitative assessments by using a bayesian inversion method in order to estimate the parameters (e.g. sampl...

  16. Experimental Validation of Plasma Metasurfaces as Tunable THz Reflectors

    Science.gov (United States)

    Colon Quinones, Roberto; Underwood, Thomas; Cappelli, Mark

    2016-10-01

    Measurements are presented which validate the use of plasma metasurfaces (PMs) as potential tunable THz reflectors. The PM considered here is an n x n array of laser produced plasma kernels generated by focusing the fundamental output from a 2 J/p Q-switched Nd:YAG laser through a multi-lens array (MLA) and into a gas of varying pressure. An M Squared Firefly-THz laser is used to generate a collimated pulse of THz light, which is then directed to the PM at varying angles of incidence. The reflected energy is measured using a Gentec-EO SDX-1187 joulemeter probe to characterize the surface impedance or reflectivity. In this presentation, we will compare the measured reflectance to values obtained from theoretical predictions and 3D finite-difference time-domain (FDTD) simulations. Work supported by the Air Force Office of Scientific Research (AFOSR). R. Colon Quinones and T. Underwood acknowledge the support of the Department of Defense (DoD) through the National Defense Science & Engineering Graduate Fellowship (NDSEG) Program.

  17. Simulation of the AC corona phenomenon with experimental validation

    Science.gov (United States)

    Villa, Andrea; Barbieri, Luca; Marco, Gondola; Malgesini, Roberto; Leon-Garzon, Andres R.

    2017-11-01

    The corona effect, and in particular the Trichel phenomenon, is an important aspect of plasma physics with many technical applications, such as pollution reduction, surface and medical treatments. This phenomenon is also associated with components used in the power industry where it is, in many cases, the source of electro-magnetic disturbance, noise and production of undesired chemically active species. Despite the power industry to date using mainly alternating current (AC) transmission, most of the studies related to the corona effect have been carried out with direct current (DC) sources. Therefore, there is technical interest in validating numerical codes capable of simulating the AC phenomenon. In this work we describe a set of partial differential equations that are comprehensive enough to reproduce the distinctive features of the corona in an AC regime. The model embeds some selectable chemical databases, comprising tens of chemical species and hundreds of reactions, the thermal dynamics of neutral species and photoionization. A large set of parameters—deduced from experiments and numerical estimations—are compared, to assess the effectiveness of the proposed approach.

  18. Experimental Validation of Elliptical Fin-Opening Behavior

    Directory of Open Access Journals (Sweden)

    James M. Garner

    2003-01-01

    Full Text Available An effort to improve the performance of ordnance has led to the consideration of the use of folding elliptical fins for projectile stabilization. A second order differential equation was used to model elliptical fin deployment history and accounts for: deployment with respect to the geometric properties of the fin, the variation in fin aerodynamics during deployment, the initial yaw effect on fin opening, and the variation in deployment speed based on changes in projectile spin. This model supports tests conducted at the Transonic Experimental Facility, Aberdeen Proving Ground examining the opening behavior of these uniquely shaped fins. The fins use the centrifugal force from the projectile spin to deploy. During the deployment, the fin aerodynamic forces vary with angle-of-attack changes to the free stream. Model results indicate that projectile spin dominates the initial opening rates and aerodynamics dominate near the fully open state. The model results are examined to explain the observed behaviors, and suggest improvements for later designs.

  19. Pore Topology Method: Experimental Validation and Dynamic Features

    Science.gov (United States)

    Riasi, M. S.; Mostaghimi, P.; Armstrong, R. T.; Yeghiazarian, L.

    2016-12-01

    Pore Topology Method (PTM) is a recently developed pore scale modeling approach to simulate multi-phase flow in porous materials. The core of PTM is to reduce the complexity of the 3-D void space geometry to its medial surface, and then use it as the solution domain. PTM hence provides a simple, topologically consistent and computationally fast methodology to simulate multi-phase flow in porous materials. In our previous work we demonstrated that the resulting permeability and capillary pressure curves for a set of isotropic fibrous materials with 25-95% porosities match those of current sophisticated approaches such as lattice Boltzmann, finite volume method, volume-of-fluid and pore morphology [1]. To test the capability of PTM in characterizing flow in low-porosity fractured media, we have implemented PTM on a 0.5% porosity coal sample. Our results are in excellent agreement with experimental data and simulation results from other software packages. Our current efforts are focused on developing Dynamic PTM to simulate transient flow in porous media. In this presentation, we will briefly report on our progress in this area. [1] Riasi, M. S., Palakurthi, N. K., Montemagno, C., & Yeghiazarian, L. (2016). A Feasibility Study of the Pore Topology Method (PTM), A Medial Surface-Based Approach to Multi-phase Flow Simulation in Porous Media. Transport in Porous Media, 1-21.

  20. Experimental validation of a self-calibrating cryogenic mass flowmeter

    Science.gov (United States)

    Janzen, A.; Boersch, M.; Burger, B.; Drache, J.; Ebersoldt, A.; Erni, P.; Feldbusch, F.; Oertig, D.; Grohmann, S.

    2017-12-01

    The Karlsruhe Institute of Technology (KIT) and the WEKA AG jointly develop a commercial flowmeter for application in helium cryostats. The flowmeter functions according to a new thermal measurement principle that eliminates all systematic uncertainties and enables self-calibration during real operation. Ideally, the resulting uncertainty of the measured flow rate is only dependent on signal noises, which are typically very small with regard to the measured value. Under real operating conditions, cryoplant-dependent flow rate fluctuations induce an additional uncertainty, which follows from the sensitivity of the method. This paper presents experimental results with helium at temperatures between 30 and 70 K and flow rates in the range of 4 to 12 g/s. The experiments were carried out in a control cryostat of the 2 kW helium refrigerator of the TOSKA test facility at KIT. Inside the cryostat, the new flowmeter was installed in series with a Venturi tube that was used for reference measurements. The measurement results demonstrate the self-calibration capability during real cryoplant operation. The influences of temperature and flow rate fluctuations on the self-calibration uncertainty are discussed.

  1. Metabolic flux distributions: genetic information, computational predictions, and experimental validation.

    Science.gov (United States)

    Blank, Lars M; Kuepfer, Lars

    2010-05-01

    Flux distributions in intracellular metabolic networks are of immense interest to fundamental and applied research, since they are quantitative descriptors of the phenotype and the operational mode of metabolism in the face of external growth conditions. In particular, fluxes are of relevance because they do not belong to the cellular inventory (e.g., transcriptome, proteome, metabolome), but are rather quantitative moieties, which link the phenotype of a cell to the specific metabolic mode of operation. A frequent application of measuring and redirecting intracellular fluxes is strain engineering, which ultimately aims at shifting metabolic activity toward a desired product to achieve a high yield and/or rate. In this article, we first review the assessment of intracellular flux distributions by either qualitative or rather quantitative computational methods and also discuss methods for experimental measurements. The tools at hand will then be exemplified on strain engineering projects from the literature. Finally, the achievements are discussed in the context of future developments in Metabolic Engineering and Synthetic Biology.

  2. Experimental validation of a computer simulation of radiographic film

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Elicardo A. de S., E-mail: elicardo.goncalves@ifrj.edu.br [Instituto Federal do Rio de Janeiro (IFRJ), Paracambi, RJ (Brazil). Laboratorio de Instrumentacao e Simulacao Computacional Cientificas Aplicadas; Azeredo, Raphaela, E-mail: raphaelaazeredo@yahoo.com.br [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Instituto de Fisica Armando Dias Tavares. Programa de Pos-Graduacao em Fisica; Assis, Joaquim T., E-mail: joaquim@iprj.uerj.br [Universidade do Estado do Rio de Janeiro (UERJ), Nova Friburgo, RJ (Brazil). Instituto Politecnico; Anjos, Marcelino J. dos; Oliveira, Davi F.; Oliveira, Luis F. de, E-mail: marcelin@uerj.br, E-mail: davi.oliveira@uerj.br, E-mail: lfolive@uerj.br [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Instituto de Fisica Armando Dias Tavares. Departamento de Fisica Aplicada e Termodinamica

    2015-07-01

    In radiographic films, the behavior of characteristic curve is very important for the image quality. Digitization/visualization are always performed by light transmission and the characteristic curve is known as a behavior of optical density in function of exposure. In a first approach, in a Monte-Carlo computer simulation trying to build a Hurter-Driffield curve by a stochastic model, the results showed the same known shape, but some behaviors, like the influence of silver grain size, are not expected. A real H and D curve was build exposing films, developing and measuring the optical density. When comparing model results with a real curve, trying to fit them and estimating some parameters, a difference in high exposure region shows a divergence between the models and the experimental data. Since the optical density is a function of metallic silver generated by chemical development, direct proportion was considered, but the results suggests a limitation in this proportion. In fact, when the optical density was changed by another way to measure silver concentration, like x-ray fluorescence, the new results agree with the models. Therefore, overexposed films can contain areas with different silver concentrations but it can't be seen due to the fact that optical density measurement is limited. Mapping the silver concentration in the film area can be a solution to reveal these dark images, and x-ray fluorescence has shown to be the best way to perform this new way to digitize films. (author)

  3. Energy efficiency of lighting installations: Software application and experimental validation

    Directory of Open Access Journals (Sweden)

    J.A. Lobão

    2015-11-01

    Full Text Available The rational use of energy and energy-efficient environmental public street lighting is an important topic. In the design of new public lighting installations, national regulations containing energy-efficient guidelines are already used. Nevertheless, either in new installations or in reconstructions of existing lighting, designers do not generally consider all the available means to save energy. In installations of street lighting, energy consumption can be reduced by reducing the losses in the conductors, associated with the efficiency of the equipment, allowing better use of the available energy. The losses in the conductors must be analysed in conjunction with all the loads that contribute to the current in the sections of the installed street lighting. When opting for more efficient lamps and luminaires or lighting control systems, the current decreases in the sections covered with the most significant power loss due to proportionality with the square of the current. This decrease, often forgotten, is considered in this work in the investment analysis of efficiency and sustainable street lighting via simulation and experimental results. This analysis, combined with the features and operating parameters of the electrical installation, accounts for all the gains that can make a difference in the choice of efficient street lighting.

  4. Helicopter noise in hover: Computational modelling and experimental validation

    Science.gov (United States)

    Kopiev, V. F.; Zaytsev, M. Yu.; Vorontsov, V. I.; Karabasov, S. A.; Anikin, V. A.

    2017-11-01

    The aeroacoustic characteristics of a helicopter rotor are calculated by a new method, to assess its applicability in assessing rotor performance in hovering. Direct solution of the Euler equations in a noninertial coordinate system is used to calculate the near-field flow around the spinning rotor. The far-field noise field is calculated by the Ffowcs Williams-Hawkings (FW-H) method using permeable control surfaces that include the blade. For a multiblade rotor, the signal obtained is duplicated and shifted in phase for each successive blade. By that means, the spectral characteristics of the far-field noise may be obtained. To determine the integral aerodynamic characteristics of the rotor, software is written to calculate the thrust and torque characteristics from the near-field flow solution. The results of numerical simulation are compared with experimental acoustic and aerodynamic data for a large-scale model of a helicopter main rotor in an open test facility. Two- and four-blade configurations of the rotor are considered, in different hover conditions. The proposed method satisfactorily predicts the aerodynamic characteristics of the blades in such conditions and gives good estimates for the first harmonics of the noise. That permits the practical use of the proposed method, not only for hovering but also for forward flight.

  5. Evaluation of 16S rRNA gene primer pairs for monitoring microbial community structures showed high reproducibility within and low comparability between datasets generated with multiple archaeal and bacterial primer pairs

    Directory of Open Access Journals (Sweden)

    Martin Alexander Fischer

    2016-08-01

    Full Text Available The application of next-generation sequencing technology in microbial community analysis increased our knowledge and understanding of the complexity and diversity of a variety of ecosystems. In contrast to Bacteria, the archaeal domain was often not particularly addressed in the analysis of microbial communities. Consequently, established primers specifically amplifying the archaeal 16S ribosomal gene region are scarce compared to the variety of primers targeting bacterial sequences. In this study, we aimed to validate archaeal primers suitable for high throughput next generation sequencing. Three archaeal 16S primer pairs as well as two bacterial and one general microbial 16S primer pairs were comprehensively tested by in-silico evaluation and performing an experimental analysis of a complex microbial community of a biogas reactor. The results obtained clearly demonstrate that comparability of community profiles established using different primer pairs is difficult. 16S rRNA gene data derived from a shotgun metagenome of the same reactor sample added an additional perspective on the community structure. Furthermore, in-silico evaluation of primers, especially those for amplification of archaeal 16S rRNA gene regions, does not necessarily reflect the results obtained in experimental approaches. In the latter, archaeal primer pair ArchV34 showed the highest similarity to the archaeal community structure compared to observed by the metagenomic approach and thus appears to be the appropriate for analyzing archaeal communities in biogas reactors. However, a disadvantage of this primer pair was its low specificity for the archaeal domain in the experimental application leading to high amounts of bacterial sequences within the dataset. Overall our results indicate a rather limited comparability between community structures investigated and determined using different primer pairs as well as between metagenome and 16S rRNA gene amplicon based community

  6. Experimental Methodology in English Teaching and Learning: Method Features, Validity Issues, and Embedded Experimental Design

    Science.gov (United States)

    Lee, Jang Ho

    2012-01-01

    Experimental methods have played a significant role in the growth of English teaching and learning studies. The paper presented here outlines basic features of experimental design, including the manipulation of independent variables, the role and practicality of randomised controlled trials (RCTs) in educational research, and alternative methods…

  7. Students' Epistemologies about Experimental Physics: Validating the Colorado Learning Attitudes about Science Survey for Experimental Physics

    Science.gov (United States)

    Wilcox, Bethany R.; Lewandowski, H. J.

    2016-01-01

    Student learning in instructional physics labs represents a growing area of research that includes investigations of students' beliefs and expectations about the nature of experimental physics. To directly probe students' epistemologies about experimental physics and support broader lab transformation efforts at the University of Colorado Boulder…

  8. JANNUS: experimental validation at the scale of atomic modelling

    Science.gov (United States)

    Serruys, Yves; Ruault, Marie-Odile; Trocellier, Patrick; Miro, Sandrine; Barbu, Alain; Boulanger, Loïc; Kaïtasov, Odile; Henry, Sylvain; Leseigneur, Olivier; Trouslard, Philippe; Pellegrino, Stéphanie; Vaubaillon, Sylvain

    2008-04-01

    Ion irradiation is well suited to simulate neutron irradiation because primary knock-on atoms (PKA) produced by neutron collisions are self ions of the target. As the main difference, the energy spectrum of ion-produced PKAs is somewhat broader than in the case of fast neutrons. Studies of the combined effects of target damaging, ion implantation effects, helium and hydrogen production, and the occurrence of nuclear reactions should be performed by co-irradiation experiments (dual or triple beam irradiation). The JANNUS project (Joint Accelerators for Nanosciences and NUclear Simulation) was started in 2002 in the frame of a collaboration between CEA (Commissariat à l'Énergie Atomique) and CNRS-IN2P3 (Centre National de la Recherche Scientifique-Institut National de Physique Nucléaire et de Physique des Particules). Two experimental sites are involved. At Saclay, three electrostatic accelerators are being coupled: a new 3 MV Pelletron™ machine equipped with an ECR multi-charged ion source, a 2.5 MV single ended Van de Graaff and a 2.25 MV General Ionex tandem. At Orsay, the 2 MV tandem ARAMIS and the 190 kV ion implanter IRMA are being coupled with a 200 kV TECNAI™ transmission electron microscope to allow simultaneous co-irradiation and observation. This paper will first discuss both advantages and limitations of the use of ion beam irradiation to simulate neutron irradiation. A technical description of both set-ups is then presented, and some details will be given concerning multi-irradiation facilities running worldwide. The main application fields of JANNUS will be further detailed. To cite this article: Y. Serruys et al., C. R. Physique 9 (2008).

  9. Microbial dormancy improves development and experimental validation of ecosystem model.

    Science.gov (United States)

    Wang, Gangsheng; Jagadamma, Sindhu; Mayes, Melanie A; Schadt, Christopher W; Steinweg, J Megan; Gu, Lianhong; Post, Wilfred M

    2015-01-01

    Climate feedbacks from soils can result from environmental change followed by response of plant and microbial communities, and/or associated changes in nutrient cycling. Explicit consideration of microbial life-history traits and functions may be necessary to predict climate feedbacks owing to changes in the physiology and community composition of microbes and their associated effect on carbon cycling. Here we developed the microbial enzyme-mediated decomposition (MEND) model by incorporating microbial dormancy and the ability to track multiple isotopes of carbon. We tested two versions of MEND, that is, MEND with dormancy (MEND) and MEND without dormancy (MEND_wod), against long-term (270 days) carbon decomposition data from laboratory incubations of four soils with isotopically labeled substrates. MEND_wod adequately fitted multiple observations (total C-CO2 and (14)C-CO2 respiration, and dissolved organic carbon), but at the cost of significantly underestimating the total microbial biomass. MEND improved estimates of microbial biomass by 20-71% over MEND_wod. We also quantified uncertainties in parameters and model simulations using the Critical Objective Function Index method, which is based on a global stochastic optimization algorithm, as well as model complexity and observational data availability. Together our model extrapolations of the incubation study show that long-term soil incubations with experimental data for multiple carbon pools are conducive to estimate both decomposition and microbial parameters. These efforts should provide essential support to future field- and global-scale simulations, and enable more confident predictions of feedbacks between environmental change and carbon cycling.

  10. RExPrimer: an integrated primer designing tool increases PCR effectiveness by avoiding 3' SNP-in-primer and mis-priming from structural variation

    Directory of Open Access Journals (Sweden)

    Suwannasri Payiarat

    2009-12-01

    Full Text Available Abstract Background Polymerase chain reaction (PCR is very useful in many areas of molecular biology research. It is commonly observed that PCR success is critically dependent on design of an effective primer pair. Current tools for primer design do not adequately address the problem of PCR failure due to mis-priming on target-related sequences and structural variations in the genome. Methods We have developed an integrated graphical web-based application for primer design, called RExPrimer, which was written in Python language. The software uses Primer3 as the primer designing core algorithm. Locally stored sequence information and genomic variant information were hosted on MySQLv5.0 and were incorporated into RExPrimer. Results RExPrimer provides many functionalities for improved PCR primer design. Several databases, namely annotated human SNP databases, insertion/deletion (indel polymorphisms database, pseudogene database, and structural genomic variation databases were integrated into RExPrimer, enabling an effective without-leaving-the-website validation of the resulting primers. By incorporating these databases, the primers reported by RExPrimer avoid mis-priming to related sequences (e.g. pseudogene, segmental duplication as well as possible PCR failure because of structural polymorphisms (SNP, indel, and copy number variation (CNV. To prevent mismatching caused by unexpected SNPs in the designed primers, in particular the 3' end (SNP-in-Primer, several SNP databases covering the broad range of population-specific SNP information are utilized to report SNPs present in the primer sequences. Population-specific SNP information also helps customize primer design for a specific population. Furthermore, RExPrimer offers a graphical user-friendly interface through the use of scalable vector graphic image that intuitively presents resulting primers along with the corresponding gene structure. In this study, we demonstrated the program

  11. RExPrimer: an integrated primer designing tool increases PCR effectiveness by avoiding 3' SNP-in-primer and mis-priming from structural variation.

    Science.gov (United States)

    Piriyapongsa, Jittima; Ngamphiw, Chumpol; Assawamakin, Anunchai; Wangkumhang, Pongsakorn; Suwannasri, Payiarat; Ruangrit, Uttapong; Agavatpanitch, Gallissara; Tongsima, Sissades

    2009-12-03

    Polymerase chain reaction (PCR) is very useful in many areas of molecular biology research. It is commonly observed that PCR success is critically dependent on design of an effective primer pair. Current tools for primer design do not adequately address the problem of PCR failure due to mis-priming on target-related sequences and structural variations in the genome. We have developed an integrated graphical web-based application for primer design, called RExPrimer, which was written in Python language. The software uses Primer3 as the primer designing core algorithm. Locally stored sequence information and genomic variant information were hosted on MySQLv5.0 and were incorporated into RExPrimer. RExPrimer provides many functionalities for improved PCR primer design. Several databases, namely annotated human SNP databases, insertion/deletion (indel) polymorphisms database, pseudogene database, and structural genomic variation databases were integrated into RExPrimer, enabling an effective without-leaving-the-website validation of the resulting primers. By incorporating these databases, the primers reported by RExPrimer avoid mis-priming to related sequences (e.g. pseudogene, segmental duplication) as well as possible PCR failure because of structural polymorphisms (SNP, indel, and copy number variation (CNV)). To prevent mismatching caused by unexpected SNPs in the designed primers, in particular the 3' end (SNP-in-Primer), several SNP databases covering the broad range of population-specific SNP information are utilized to report SNPs present in the primer sequences. Population-specific SNP information also helps customize primer design for a specific population. Furthermore, RExPrimer offers a graphical user-friendly interface through the use of scalable vector graphic image that intuitively presents resulting primers along with the corresponding gene structure. In this study, we demonstrated the program effectiveness in successfully generating primers for strong

  12. Primers-4-Yeast: a comprehensive web tool for planning primers for Saccharomyces cerevisiae.

    Science.gov (United States)

    Yofe, Ido; Schuldiner, Maya

    2014-02-01

    The budding yeast Saccharomyces cerevisiae is a key model organism of functional genomics, due to its ease and speed of genetic manipulations. In fact, in this yeast, the requirement for homologous sequences for recombination purposes is so small that 40 base pairs (bp) are sufficient. Hence, an enormous variety of genetic manipulations can be performed by simply planning primers with the correct homology, using a defined set of transformation plasmids. Although designing primers for yeast transformations and for the verification of their correct insertion is a common task in all yeast laboratories, primer planning is usually done manually and a tool that would enable easy, automated primer planning for the yeast research community is still lacking. Here we introduce Primers-4-Yeast, a web tool that allows primers to be designed in batches for S. cerevisiae gene-targeting transformations, and for the validation of correct insertions. This novel tool enables fast, automated, accurate primer planning for large sets of genes, introduces consistency in primer planning and is therefore suggested to serve as a standard in yeast research. Primers-4-Yeast is available at: http://www.weizmann.ac.il/Primers-4-Yeast Copyright © 2013 John Wiley & Sons, Ltd.

  13. Development of a quality-assessment tool for experimental bruxism studies: reliability and validity.

    Science.gov (United States)

    Dawson, Andreas; Raphael, Karen G; Glaros, Alan; Axelsson, Susanna; Arima, Taro; Ernberg, Malin; Farella, Mauro; Lobbezoo, Frank; Manfredini, Daniele; Michelotti, Ambra; Svensson, Peter; List, Thomas

    2013-01-01

    To combine empirical evidence and expert opinion in a formal consensus method in order to develop a quality-assessment tool for experimental bruxism studies in systematic reviews. Tool development comprised five steps: (1) preliminary decisions, (2) item generation, (3) face-validity assessment, (4) reliability and discriminitive validity assessment, and (5) instrument refinement. The kappa value and phi-coefficient were calculated to assess inter-observer reliability and discriminative ability, respectively. Following preliminary decisions and a literature review, a list of 52 items to be considered for inclusion in the tool was compiled. Eleven experts were invited to join a Delphi panel and 10 accepted. Four Delphi rounds reduced the preliminary tool-Quality-Assessment Tool for Experimental Bruxism Studies (Qu-ATEBS)- to 8 items: study aim, study sample, control condition or group, study design, experimental bruxism task, statistics, interpretation of results, and conflict of interest statement. Consensus among the Delphi panelists yielded good face validity. Inter-observer reliability was acceptable (k = 0.77). Discriminative validity was excellent (phi coefficient 1.0; P bruxism studies, exhibits face validity, excellent discriminative validity, and acceptable inter-observer reliability. Development of quality assessment tools for many other topics in the orofacial pain literature is needed and may follow the described procedure.

  14. Experimental validation of a mathematical model for seabed liquefaction in waves

    DEFF Research Database (Denmark)

    Sumer, B. Mutlu; Kirca, Özgür; Fredsøe, Jørgen

    2011-01-01

    This paper summarizes the results of an experimental study directed towards the validation of a mathematical model for the buildup of pore water pressure and resulting liquefaction of marine soils under progressive waves. Experiments were conducted under controlled conditions with silt ( d50 = 0.......070 mm) in a wave flume with a soil pit. Waves with wave heights in the range 7.7-18 cm with the water depth 55 cm and the wave period 1.6 s enabled us to study both the liquefaction and no-liquefaction regime pore water pressure buildup. The experimental data was used to validate the model. A numerical...

  15. DMFC performance and methanol cross-over: Experimental analysis and model validation

    Energy Technology Data Exchange (ETDEWEB)

    Casalegno, A.; Marchesi, R. [Dipartimento di Energia, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy)

    2008-10-15

    A combined experimental and modelling approach is proposed to analyze methanol cross-over and its effect on DMFC performance. The experimental analysis is performed in order to allow an accurate investigation of methanol cross-over influence on DMFC performance, hence measurements were characterized in terms of uncertainty and reproducibility. The findings suggest that methanol cross-over is mainly determined by diffusion transport and affects cell performance partly via methanol electro-oxidation at the cathode. The modelling analysis is carried out to further investigate methanol cross-over phenomenon. A simple model evaluates the effectiveness of two proposed interpretations regarding methanol cross-over and its effects. The model is validated using the experimental data gathered. Both the experimental analysis and the proposed and validated model allow a substantial step forward in the understanding of the main phenomena associated with methanol cross-over. The findings confirm the possibility to reduce methanol cross-over by optimizing anode feeding. (author)

  16. Error Modelling and Experimental Validation for a Planar 3-PPR Parallel Manipulator

    DEFF Research Database (Denmark)

    Wu, Guanglei; Bai, Shaoping; Kepler, Jørgen Asbøl

    2011-01-01

    In this paper, the positioning error of a 3-PPR planar parallel manipulator is studied with an error model and experimental validation. First, the displacement and workspace are analyzed. An error model considering both configuration errors and joint clearance errors is established. Using...... this model, the maximum positioning error was estimated for a U-shape PPR planar manipulator, the results being compared with the experimental measurements. It is found that the error distributions from the simulation is approximate to that of themeasurements....

  17. Experimental Validation of a Mathematical Model for Seabed Liquefaction Under Waves

    DEFF Research Database (Denmark)

    Sumer, B. Mutlu; Kirca, Özgür; Fredsøe, Jørgen

    2012-01-01

    This paper summarizes the results of an experimental study directed towards the validation of a mathematical model for the buildup of pore water pressure and resulting liquefaction of marine soils under progressive waves. Experiments were conducted under controlled conditions with silt (d(50) = 0...

  18. Experimental validation of tip over stability of a tracked mobile manipulator

    CSIR Research Space (South Africa)

    Dube, C

    2013-09-01

    Full Text Available Mobile manipulators are highly susceptible to tip over due to the motion of the manipulator or the gradient of the slope being traversed by the robot’s mobile base. This paper presents the experimental validation of the tip over stability analysis...

  19. Experimental validation of CFD mass transfer simulations in flat channels with non-woven net spacers

    NARCIS (Netherlands)

    Li, F.; Meindersma, G.W.; de Haan, A.B.; Reith, T.

    2004-01-01

    The objective of the present paper is to validate experimentally the mass transfer simulations presented in a previous paper by the same authors [J. Membr. Sci. 208 (2002) 289]. In the present study, mass transfer coefficients were obtained by the limiting current method. The results from CFD

  20. Primer3Plus, an enhanced web interface to Primer3

    NARCIS (Netherlands)

    Untergasser, A.; Nijveen, H.; Rao, X.; Bisseling, T.; Geurts, R.; Leunissen, J.A.M.

    2007-01-01

    Here we present Primer3Plus, a new web interface to the popular Primer3 primer design program as an enhanced alternative for the CGI- scripts that come with Primer3. Primer3 consists of a command line program and a web interface. The web interface is one large form showing all of the possible

  1. Advanced computational tools for PEM fuel cell design. Part 2. Detailed experimental validation and parametric study

    Science.gov (United States)

    Sui, P. C.; Kumar, S.; Djilali, N.

    This paper reports on the systematic experimental validation of a comprehensive 3D CFD-based computational model presented and documented in Part 1. Simulations for unit cells with straight channels, similar to the Ballard Mk902 hardware, are performed and analyzed in conjunction with detailed current mapping measurements and water mass distributions in the membrane-electrode assembly. The experiments were designed to display sensitivity of the cell over a range of operating parameters including current density, humidification, and coolant temperature, making the data particularly well suited for systematic validation. Based on the validation and analysis of the predictions, values of model parameters, including the electro-osmotic drag coefficient, capillary diffusion coefficient, and catalyst specific surface area are determined adjusted to fit experimental data of current density and MEA water content. The predicted net water flux out of the anode (normalized by the total water generated) increases as anode humidification water flow rate is increased, in agreement with experimental results. A modification of the constitutive equation for the capillary diffusivity of water in the porous electrodes that attempts to incorporate the experimentally observed immobile (or irreducible) saturation yields a better fit of the predicted MEA water mass with experimental data. The specific surface area parameter used in the catalyst layer model is found to be effective in tuning the simulations to predict the correct cell voltage over a range of stoichiometries.

  2. Experimental Validation of the Butyl-Rubber Finite Element (FE) Material Model for the Blast-Mitigating Floor Mat

    Science.gov (United States)

    2015-08-01

    Experimental Validation of the Butyl- Rubber Finite Element (FE) Material Model for the Blast-Mitigating Floor Mat by Masayuki Sakamoto...MD 20783-1138 ARL-SR-0329 August 2015 Experimental Validation of the Butyl- Rubber Finite Element (FE) Material Model for the Blast...SUBTITLE Experimental Validation of the Butyl- Rubber Finite Element (FE) Material Model for the Blast-Mitigating Floor Mat 5a. CONTRACT NUMBER 5b

  3. An Experimental Simulation to Validate FEM to Predict Transverse Young’s Modulus of FRP Composites

    Directory of Open Access Journals (Sweden)

    V. S. Sai

    2013-01-01

    Full Text Available Finite element method finds application in the analysis of FRP composites due to its versatility in getting the solution for complex cases which are not possible by exact classical analytical approaches. The finite element result is questionable unless it is obtained from converged mesh and properly validated. In the present work specimens are prepared with metallic materials so that the arrangement of fibers is close to hexagonal packing in a matrix as similar arrangement in case of FRP is complex due to the size of fibers. Transverse Young’s moduli of these specimens are determined experimentally. Equivalent FE models are designed and corresponding transverse Young’s moduli are compared with the experimental results. It is observed that the FE values are in good agreement with the experimental results, thus validating FEM for predicting transverse modulus of FRP composites.

  4. Experimental validation of the buildings energy performance (PEC assessment methods with reference to occupied spaces heating

    Directory of Open Access Journals (Sweden)

    Cristian PETCU

    2010-01-01

    Full Text Available This paper is part of the series of pre-standardization research aimed to analyze the existing methods of calculating the Buildings Energy Performance (PEC in view of their correction of completing. The entire research activity aims to experimentally validate the PEC Calculation Algorithm as well as the comparative application, on the support of several case studies focused on representative buildings of the stock of buildings in Romania, of the PEC calculation methodology for buildings equipped with occupied spaces heating systems. The targets of the report are the experimental testing of the calculation models so far known (NP 048-2000, Mc 001-2006, SR EN 13790:2009, on the support provided by the CE INCERC Bucharest experimental building, together with the complex calculation algorithms specific to the dynamic modeling, for the evaluation of the occupied spaces heat demand in the cold season, specific to the traditional buildings and to modern buildings equipped with solar radiation passive systems, of the ventilated solar space type. The schedule of the measurements performed in the 2008-2009 cold season is presented as well as the primary processing of the measured data and the experimental validation of the heat demand monthly calculation methods, on the support of CE INCERC Bucharest. The calculation error per heating season (153 days of measurements between the measured heat demand and the calculated one was of 0.61%, an exceptional value confirming the phenomenological nature of the INCERC method, NP 048-2006. The mathematical model specific to the hourly thermal balance is recurrent – decisional with alternating paces. The experimental validation of the theoretical model is based on the measurements performed on the CE INCERC Bucharest building, within a time lag of 57 days (06.01-04.03.2009. The measurements performed on the CE INCERC Bucharest building confirm the accuracy of the hourly calculation model by comparison to the values

  5. Approaches to experimental validation of high-temperature gas-cooled reactor components

    Energy Technology Data Exchange (ETDEWEB)

    Belov, S.E. [Joint Stock Company ' Afrikantov OKB Mechanical Engineering' , Burnakovsky Proezd, 15, Nizhny Novgorod 603074 (Russian Federation); Borovkov, M.N., E-mail: borovkov@okbm.nnov.ru [Joint Stock Company ' Afrikantov OKB Mechanical Engineering' , Burnakovsky Proezd, 15, Nizhny Novgorod 603074 (Russian Federation); Golovko, V.F.; Dmitrieva, I.V.; Drumov, I.V.; Znamensky, D.S.; Kodochigov, N.G. [Joint Stock Company ' Afrikantov OKB Mechanical Engineering' , Burnakovsky Proezd, 15, Nizhny Novgorod 603074 (Russian Federation); Baxi, C.B.; Shenoy, A.; Telengator, A. [General Atomics, 3550 General Atomics Court, CA (United States); Razvi, J., E-mail: Junaid.Razvi@ga.com [General Atomics, 3550 General Atomics Court, CA (United States)

    2012-10-15

    Highlights: Black-Right-Pointing-Pointer Computational and experimental investigations of thermal and hydrodynamic characteristics for the equipment. Black-Right-Pointing-Pointer Vibroacoustic investigations. Black-Right-Pointing-Pointer Studies of the electromagnetic suspension system on GT-MHR turbo machine rotor models. Black-Right-Pointing-Pointer Experimental investigations of the catcher bearings design. - Abstract: The special feature of high-temperature gas-cooled reactors (HTGRs) is stressed operating conditions for equipment due to high temperature of the primary circuit helium, up to 950 Degree-Sign C, as well as acoustic and hydrodynamic loads upon the gas path elements. Therefore, great significance is given to reproduction of real operation conditions in tests. Experimental investigation of full-size nuclear power plant (NPP) primary circuit components is not practically feasible because costly test facilities will have to be developed for the power of up to hundreds of megawatts. Under such conditions, the only possible process to validate designs under development is representative tests of smaller scale models and fragmentary models. At the same time, in order to take in to validated account the effect of various physical factors, it is necessary to ensure reproduction of both individual processes and integrated tests incorporating needed integrated investigations. Presented are approaches to experimental validation of thermohydraulic and vibroacoustic characteristics for main equipment components and primary circuit path elements under standard loading conditions, which take account of their operation in the HTGR. Within the framework of the of modular helium reactor project, including a turbo machine in the primary circuit, a new and difficult problem is creation of multiple-bearing flexible vertical rotor. Presented are approaches to analytical and experimental validation of the rotor electromagnetic bearings, catcher bearings, flexible rotor

  6. Validation of a Wave-Body Interaction Model by Experimental Tests

    DEFF Research Database (Denmark)

    Ferri, Francesco; Kramer, Morten; Pecher, Arthur

    2013-01-01

    Within the wave energy field, numerical simulation has recently acquired a worldwide consent as being a useful tool, besides physical model testing. The main goal of this work is the validation of a numerical model by experimental results. The numerical model is based on a linear wave-body intera......-body interaction theory, applied for a point absorber wave energy converter. The results show that the ratio floater size/wave amplitude is a key parameter for the validity of the applied theory....

  7. Development and Validation of a Rubric for Diagnosing Students’ Experimental Design Knowledge and Difficulties

    Science.gov (United States)

    Dasgupta, Annwesa P.; Anderson, Trevor R.

    2014-01-01

    It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students’ responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students’ experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. PMID:26086658

  8. 3D strain map of axially loaded mouse tibia: a numerical analysis validated by experimental measurements.

    Science.gov (United States)

    Stadelmann, Vincent A; Hocke, Jean; Verhelle, Jensen; Forster, Vincent; Merlini, Francesco; Terrier, Alexandre; Pioletti, Dominique P

    2009-02-01

    A combined experimental/numerical study was performed to calculate the 3D octahedral shear strain map in a mouse tibia loaded axially. This study is motivated by the fact that the bone remodelling analysis, in this in vivo mouse model should be performed at the zone of highest mechanical stimulus to maximise the measured effects. Accordingly, it is proposed that quantification of bone remodelling should be performed at the tibial crest and at the distal diaphysis. The numerical model could also be used to furnish a more subtle analysis as a precise correlation between local strain and local biological response can be obtained with the experimentally validated numerical model.

  9. An experimentally validated simulation model for a four-stage spray dryer

    DEFF Research Database (Denmark)

    Petersen, Lars Norbert; Poulsen, Niels Kjølstad; Niemann, Hans Henrik

    2017-01-01

    is divided into four consecutive stages: a primary spray drying stage, two heated fluid bed stages, and a cooling fluid bed stage. Each of these stages in the model is assumed ideally mixed and the dynamics are described by mass- and energy balances. These balance equations are coupled with constitutive...... mathematical model is an index-1 differential algebraic equation (DAE) model with 12 states, 9 inputs, 8 disturbances, and 30 parameters. The parameters in the model are identified from well-excited experimental data obtained from the industrialtype spray dryer. The simulated outputs ofthe model are validated...... using independent well-excited experimental data from the same spray dryer. The simulated temperatures, humidities, and residual moistures in the spray dryer compare well to the validation data. The model also provides the profit of operation, the production rate, the energy consumption, and the energy...

  10. Psychometric evaluation and experimental validation of the statistics anxiety rating scale.

    Science.gov (United States)

    Papousek, Ilona; Ruggeri, Kai; Macher, Daniel; Paechter, Manuela; Heene, Moritz; Weiss, Elisabeth M; Schulter, Günter; Freudenthaler, H Harald

    2012-01-01

    The Statistics Anxiety Rating Scale (STARS) was adapted into German to examine its psychometric properties (n = 400). Two validation studies (n = 66, n = 96) were conducted to examine its criterion-related validity. The psychometric properties of the questionnaire were very similar to those previously reported for the original English version in various countries and other language versions. Confirmatory factor analysis indicated 2 second-order factors: One was more closely related to anxiety and the other was more closely related to negative attitudes toward statistics. Predictive validity of the STARS was shown both in an experimental exam-like situation in the laboratory and during a real examination situation. Taken together, the findings indicate that statistics anxiety as assessed by the STARS is a useful construct that is more than just an expression of a more general disposition to anxiety.

  11. Physics-based Modeling Techniques for Analysis and Design of Advanced Suspension Systems with Experimental Validation

    OpenAIRE

    Farjoud, Alireza

    2011-01-01

    This research undertakes the problem of vibration control of vehicular and structural systems using intelligent materials and controllable devices. Advanced modeling tools validated with experimental test data are developed to help with understanding the fundamentals as well as advanced and novel applications of smart and conventional suspension systems. The project can be divided into two major parts. The first part is focused on development of novel smart suspensions using Magneto-Rheolo...

  12. Finite Element Simulations of stretch-blow moulding with experimental validation over a broad process window

    OpenAIRE

    Nixon, James; Menary, Gary; Yan, Shiyong

    2017-01-01

    Injection stretch blow moulding is a well-established method of forming thin-walled containers and has been extensively researched for numerous years. This paper is concerned with validating the finite element analysis of the free-stretch-blow process in an effort to progress the development of injection stretch blow moulding of poly(ethylene terephthalate). Extensive data was obtained experimentally over a wide process window accounting for material temperature and air flow rate, while captu...

  13. Relationships between the decoupled and coupled transfer functions: Theoretical studies and experimental validation

    Science.gov (United States)

    Wang, Zengwei; Zhu, Ping; Liu, Zhao

    2018-01-01

    A generalized method for predicting the decoupled transfer functions based on in-situ transfer functions is proposed. The method allows predicting the decoupled transfer functions using coupled transfer functions, without disassembling the system. Two ways to derive relationships between the decoupled and coupled transfer functions are presented. Issues related to immeasurability of coupled transfer functions are also discussed. The proposed method is validated by numerical and experimental case studies.

  14. Effective experimental validation of miRNA targets using an improved linker reporter assay.

    Science.gov (United States)

    Choi, Cheolwon; Han, James; Thao Tran, Nguyen Thi; Yoon, Seulgi; Kim, Goeun; Song, Sujung; Kim, Youngjo; Ryu, Seongho

    2017-01-30

    miRNAs are small, non-coding RNAs that play critical roles in various cellular processes. Although there are several algorithms that can predict the potential candidate genes that are regulated by a miRNA, these algorithms require further experimental validation in order to demonstrate genuine targets of miRNAs. Moreover, most algorithms predict hundreds to thousands of putative target genes for each miRNA, and it is difficult to validate all candidates using the whole 3'-untranslated region (UTR) reporter assay. We report a fast, simple and efficient experimental approach to screening miRNA candidate targets using a 3'-UTR linker assay. Critically, the linker has only a short miRNA regulatory element sequence of approximately 22 base pairs in length and can provide a benefit for screening strong miRNA candidates for further validation using the whole 3'-UTR sequence. Our technique will provide a simplified platform for the high-throughput screening of miRNA target gene validation.

  15. Asset management primer

    Science.gov (United States)

    1999-12-01

    According to this primer, asset management is a systematic process of maintaining, upgrading, and operating physical assets cost-effectively. It combines engineering principles with sound business practices and economic theory, and it provides tools ...

  16. 40 CFR 761.386 - Required experimental conditions for the validation study and subsequent use during decontamination.

    Science.gov (United States)

    2010-07-01

    ... the validation study and subsequent use during decontamination. 761.386 Section 761.386 Protection of... Validating a New Performance-Based Decontamination Solvent Under § 761.79(d)(4) § 761.386 Required experimental conditions for the validation study and subsequent use during decontamination. The following...

  17. methBLAST and methPrimerDB: web-tools for PCR based methylation analysis

    Directory of Open Access Journals (Sweden)

    Herzog Robert

    2006-11-01

    Full Text Available Abstract Background DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methylation assays on bisulphite modified DNA heralded a breakthrough in speed and sensitivity for gene methylation analysis. Despite this technological advancement, these approaches require a cumbersome gene by gene primer design and experimental validation. Bisulphite DNA modification results in sequence alterations (all unmethylated cytosines are converted into uracils and a general sequence complexity reduction as cytosines become underrepresented. Consequently, standard BLAST sequence homology searches cannot be applied to search for specific methylation primers. Results To address this problem we developed methBLAST, a sequence similarity search program, based on the original BLAST algorithm but querying in silico bisulphite modified genome sequences to evaluate oligonucleotide sequence similarities. Apart from the primer specificity analysis tool, we have also developed a public database termed methPrimerDB for the storage and retrieval of validated PCR based methylation assays. The web interface allows free public access to perform methBLAST searches or database queries and to submit user based information. Database records can be searched by gene symbol, nucleotide sequence, analytical method used, Entrez Gene or methPrimerDB identifier, and submitter's name. Each record contains a link to Entrez Gene and PubMed to retrieve additional information on the gene, its genomic context and the article in which the methylation assay was described. To assure and maintain data integrity and accuracy, the database is linked to other reference databases. Currently, the database contains primer records for the most popular PCR-based methylation analysis methods to study human, mouse and rat epigenetic modifications. methPrimerDB and methBLAST are available at http

  18. Charge Reduction Potentials of Several Refrigerants Based on Experimentally Validated Micro-Channel Heat Exchangers Performance and Charge Model

    OpenAIRE

    Padilla Fuentes, Yadira; Hrnjak, Predrag S.

    2012-01-01

    This paper presents an experimentally validated simulation model developed to obtain accurate prediction of evaporator microchannel heat exchanger performance and charge. Effects of using various correlations are presented and discussed with focus on serpentine microchannel evaporators. Experiments with propane are used to validate the model. The experimentally validated model is used to compare the charge reduction potential of various refrigerants. The procedure for charge reduction analysi...

  19. Macroscopic Dynamic Modeling of Sequential Batch Cultures of Hybridoma Cells: An Experimental Validation

    Directory of Open Access Journals (Sweden)

    Laurent Dewasme

    2017-02-01

    Full Text Available Hybridoma cells are commonly grown for the production of monoclonal antibodies (MAb. For monitoring and control purposes of the bioreactors, dynamic models of the cultures are required. However these models are difficult to infer from the usually limited amount of available experimental data and do not focus on target protein production optimization. This paper explores an experimental case study where hybridoma cells are grown in a sequential batch reactor. The simplest macroscopic reaction scheme translating the data is first derived using a maximum likelihood principal component analysis. Subsequently, nonlinear least-squares estimation is used to determine the kinetic laws. The resulting dynamic model reproduces quite satisfactorily the experimental data, as evidenced in direct and cross-validation tests. Furthermore, model predictions can also be used to predict optimal medium renewal time and composition.

  20. Experimental validation of finite element modelling of a modular metal-on-polyethylene total hip replacement.

    Science.gov (United States)

    Hua, Xijin; Wang, Ling; Al-Hajjar, Mazen; Jin, Zhongmin; Wilcox, Ruth K; Fisher, John

    2014-07-01

    Finite element models are becoming increasingly useful tools to conduct parametric analysis, design optimisation and pre-clinical testing for hip joint replacements. However, the verification of the finite element model is critically important. The purposes of this study were to develop a three-dimensional anatomic finite element model for a modular metal-on-polyethylene total hip replacement for predicting its contact mechanics and to conduct experimental validation for a simple finite element model which was simplified from the anatomic finite element model. An anatomic modular metal-on-polyethylene total hip replacement model (anatomic model) was first developed and then simplified with reasonable accuracy to a simple modular total hip replacement model (simplified model) for validation. The contact areas on the articulating surface of three polyethylene liners of modular metal-on-polyethylene total hip replacement bearings with different clearances were measured experimentally in the Leeds ProSim hip joint simulator under a series of loading conditions and different cup inclination angles. The contact areas predicted from the simplified model were then compared with that measured experimentally under the same conditions. The results showed that the simplification made for the anatomic model did not change the predictions of contact mechanics of the modular metal-on-polyethylene total hip replacement substantially (less than 12% for contact stresses and contact areas). Good agreements of contact areas between the finite element predictions from the simplified model and experimental measurements were obtained, with maximum difference of 14% across all conditions considered. This indicated that the simplification and assumptions made in the anatomic model were reasonable and the finite element predictions from the simplified model were valid. © IMechE 2014.

  1. Development and Validation of a Rubric for Diagnosing Students' Experimental Design Knowledge and Difficulties.

    Science.gov (United States)

    Dasgupta, Annwesa P; Anderson, Trevor R; Pelaez, Nancy

    2014-01-01

    It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students' responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students' experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. © 2014 A. P. Dasgupta et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  2. An Experimental Validated Control Strategy of Maglev Vehicle-Bridge Self-Excited Vibration

    Directory of Open Access Journals (Sweden)

    Lianchun Wang

    2017-01-01

    Full Text Available This study discusses an experimentally validated control strategy of maglev vehicle-bridge vibration, which degrades the stability of the suspension control, deteriorates the ride comfort, and limits the cost of the magnetic levitation system. First, a comparison between the current-loop and magnetic flux feedback is carried out and a minimum model including flexible bridge and electromagnetic levitation system is proposed. Then, advantages and disadvantages of the traditional feedback architecture with the displacement feedback of electromagnet yE and bridge yB in pairs are explored. The results indicate that removing the feedback of the bridge’s displacement yB from the pairs (yE − yB measured by the eddy-current sensor is beneficial for the passivity of the levitation system and the control of the self-excited vibration. In this situation, the signal acquisition of the electromagnet’s displacement yE is discussed for the engineering application. Finally, to validate the effectiveness of the aforementioned control strategy, numerical validations are carried out and the experimental data are provided and analyzed.

  3. Modeling and Experimental Validation of a Transient Direct Expansion Heat Pump

    Directory of Open Access Journals (Sweden)

    Clément Rousseau

    2017-06-01

    Full Text Available Geothermal heat pump technology is currently one of the most interesting technologies used to heat buildings. There are two designs used in the industry: geothermal heat pump using a secondary ground loop and Direct Expansion (DX ground source heat pump. The latter is less used, possibly because less research has been carried out for the design of this kind of heat pump. In this paper, a transient model using the Comsol Multiphysic of a DX ground heat pump is presented in heating mode with R22, and a comparison with experimental results is presented with a 24-hour test. It is shown that the model was adequately validated by our experiment with only a maximum difference of 15%. Following this validation, a parametric analysis was realised on the geometry of the borehole. This study concluded that to have the best heat extraction of the ground, the pipes shank spacing need to be important without increasing the borehole diameter. Keywords: Direct Expansion geothermal heat pump, Modeling, R22 Article History: Received January 16th 2017; Received in revised form May 28th 2017; Accepted June 6th 2017; Available online How to Cite This Article: Rousseau, C., Fannou, J.L.C., Lamarche, L. and Kajl, S. (2017 Modeling and Experimental Validation of a Transient Direct Expansion Heat Pump. International Journal of Renewable Energy Develeopment, 6(2, 145-155. https://doi.org/10.14710/ijred.6.2.145-155

  4. Dynamic modeling and experimental validation for direct contact membrane distillation (DCMD) process

    KAUST Repository

    Eleiwi, Fadi

    2016-02-01

    This work proposes a mathematical dynamic model for the direct contact membrane distillation (DCMD) process. The model is based on a 2D Advection–Diffusion Equation (ADE), which describes the heat and mass transfer mechanisms that take place inside the DCMD module. The model studies the behavior of the process in the time varying and the steady state phases, contributing to understanding the process performance, especially when it is driven by intermittent energy supply, such as the solar energy. The model is experimentally validated in the steady state phase, where the permeate flux is measured for different feed inlet temperatures and the maximum absolute error recorded is 2.78 °C. Moreover, experimental validation includes the time variation phase, where the feed inlet temperature ranges from 30 °C to 75 °C with 0.1 °C increment every 2min. The validation marks relative error to be less than 5%, which leads to a strong correlation between the model predictions and the experiments.

  5. Validation of NEPTUNE-CFD Two-Phase Flow Models Using Experimental Data

    Directory of Open Access Journals (Sweden)

    Jorge Pérez Mañes

    2014-01-01

    Full Text Available This paper deals with the validation of the two-phase flow models of the CFD code NEPTUNEC-CFD using experimental data provided by the OECD BWR BFBT and PSBT Benchmark. Since the two-phase models of CFD codes are extensively being improved, the validation is a key step for the acceptability of such codes. The validation work is performed in the frame of the European NURISP Project and it was focused on the steady state and transient void fraction tests. The influence of different NEPTUNE-CFD model parameters on the void fraction prediction is investigated and discussed in detail. Due to the coupling of heat conduction solver SYRTHES with NEPTUNE-CFD, the description of the coupled fluid dynamics and heat transfer between the fuel rod and the fluid is improved significantly. The averaged void fraction predicted by NEPTUNE-CFD for selected PSBT and BFBT tests is in good agreement with the experimental data. Finally, areas for future improvements of the NEPTUNE-CFD code were identified, too.

  6. Mesh refinement study and experimental validation for stretch bending of sheet metals

    Science.gov (United States)

    Raupach, M.; Kreissl, S.; Vuaille, L.; Möller, T.; Friebe, H.; Volk, W.

    2017-09-01

    For sheet metal parts with small radii and large bending angles, the sheet metal forming simulation reaches their application limits. Alternatives are complex shell formulations and volume elements. For volume elements, the necessary number of elements over the thickness is important. Valid values are not available depending on discrete radii. Therefore in this work, a convergence study is performed using the example of an angular stretch bend test with a radius to thickness ratio of 1. For various states of mesh refinement, simulations are performed, various results are presented, analysed and discussed with regard to convergence behaviour to the necessary number of elements in thickness direction. Recommendations for suitable validation variables are derived. Based on the refinement study, a simulation model for an experimental validation is developed. The experiments are carried out in a sheet metal forming machine. Experimental angular stretch bend test with a punch radius of 1 mm are performed until failure and the strain distribution on the top side of the sheet is measured. Finally, simulation and experiments are compared based on the surface strain.

  7. Nano-motion control of heavy quadrupoles for future particle colliders: An experimental validation

    CERN Document Server

    Collette, C; Artoos, K; Kuzmin, A; Fernandez Carmona, P; Guinchard, M; Leuxe, R; Hauviller, C

    2011-01-01

    This paper presents an experimental validation of a control strategy capable of boths tabilizing and positioning the heavy electromagnets of future particle colliders. The originality of the approach is to use the same active mounts to perform both tasks,with a nanometer precision.In aprevious paper,the concept has been studied numerically,and validated on a scaled single degree of freedom(d.o.f.) test bench.In this paper,it is extended to a two d.o.f. testbench,constituted of a heavy mass mounted on two active legs.Firstly,the model is described and the performances are discussed numerically. Secondly,experimental results are presented,and found to correlate well with the model,and comply with the requirements.Finally,the experimental results are combined with a simplified model of the beam-based feedback to evaluate the jitter of the beam.It is found that,at the scale of a single quadrupole,the mechanical stabilization of the quadrupoles reduces the vertical beam jitter by a factor 10.

  8. Validation of experimental medicine methods in psychiatry: the P1vital approach and experience.

    Science.gov (United States)

    Dawson, Gerard R; Craig, Kevin J; Dourish, Colin T

    2011-06-15

    In the pharmaceutical industry deciding whether to progress a compound to the next stage of development or choosing between compounds in a development portfolio is laden with risk. This is particularly true of compounds developed to treat CNS disorders. The use of pre-clinical models in CNS drug development is well established but these models often lack predictive validity and many compounds fail when they reach the target patient group. Bridging the gap between pre-clinical CNS models and patient studies, P1vital's objective is to develop human volunteer models that will enable rapid, accurate and reliable decision making about which compounds to progress into patient trials. The research strategy of P1vital and its academic research network is to focus on science that progresses the development of clinical efficacy models. As part of this strategy P1vital established a CNS Experimental Medicine Consortium with members from both academic research and the pharmaceutical industry. This consortium is unique in that experimental medicine models initially developed through academic research are selected for further validation in a process that is managed by the Pharma members of the P1vital CNS Experimental Medicine Consortium steering (PEM) committee. The P1vital consortium is very much a work in progress. However, since its inception in 2007 the consortium has successfully delivered results from five clinical studies in four therapeutic areas namely, anxiety, cognitive disorders, schizophrenia and depression. 2011. Published by Elsevier Inc.

  9. Experimental validation of the partial coherence model in spectroscopic ellipsometry and Mueller matrix polarimetry

    Science.gov (United States)

    Miranda-Medina, M.; Garcia-Caurel, E.; Peinado, A.; Stchakovsky, M.; Hingerl, K.; Ossikovski, R.

    2017-11-01

    In this contribution, a recently advanced analytical approach for addressing partial coherence in spectroscopic polarimetric measurements is experimentally validated. The approach is based on the fundamental representation of the measurement process as the convolution of the polarimetric response of the sample and the instrumental function of the measurement system. Experimentally, the optical responses of two optically thick transparent layers were acquired by using spectroscopic Mueller matrix polarimetry at various angles of incidence over two spectral ranges (visible and infrared). The layers are considered isotropic and the loss of coherence is assumed to originate from the finite spectral resolution of the instrument. In parallel with the analytical approximation, the standard numerical approach implemented in commercial software was likewise used to reproduce the polarimetric responses. Excellent agreement between the analytical approximation, the commercial software one and the polarimetric measurements was found. The experimental validation of the analytical approximation represents a time-saving alternative to the numerical approaches used in commercial software and is of potential interest to real-time process monitoring by using spectroscopic ellipsometry or polarimetry.

  10. Advanced Reactors-Intermediate Heat Exchanger (IHX) Coupling: Theoretical Modeling and Experimental Validation

    Energy Technology Data Exchange (ETDEWEB)

    Utgikar, Vivek [Univ. of Idaho, Moscow, ID (United States); Sun, Xiaodong [The Ohio State Univ., Columbus, OH (United States); Christensen, Richard [The Ohio State Univ., Columbus, OH (United States); Sabharwall, Piyush [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-12-29

    The overall goal of the research project was to model the behavior of the advanced reactorintermediate heat exchange system and to develop advanced control techniques for off-normal conditions. The specific objectives defined for the project were: 1. To develop the steady-state thermal hydraulic design of the intermediate heat exchanger (IHX); 2. To develop mathematical models to describe the advanced nuclear reactor-IHX-chemical process/power generation coupling during normal and off-normal operations, and to simulate models using multiphysics software; 3. To develop control strategies using genetic algorithm or neural network techniques and couple these techniques with the multiphysics software; 4. To validate the models experimentally The project objectives were accomplished by defining and executing four different tasks corresponding to these specific objectives. The first task involved selection of IHX candidates and developing steady state designs for those. The second task involved modeling of the transient and offnormal operation of the reactor-IHX system. The subsequent task dealt with the development of control strategies and involved algorithm development and simulation. The last task involved experimental validation of the thermal hydraulic performances of the two prototype heat exchangers designed and fabricated for the project at steady state and transient conditions to simulate the coupling of the reactor- IHX-process plant system. The experimental work utilized the two test facilities at The Ohio State University (OSU) including one existing High-Temperature Helium Test Facility (HTHF) and the newly developed high-temperature molten salt facility.

  11. Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin.

    Science.gov (United States)

    Barrett, Frederick S; Johnson, Matthew W; Griffiths, Roland R

    2015-11-01

    The 30-item revised Mystical Experience Questionnaire (MEQ30) was previously developed within an online survey of mystical-type experiences occasioned by psilocybin-containing mushrooms. The rated experiences occurred on average eight years before completion of the questionnaire. The current paper validates the MEQ30 using data from experimental studies with controlled doses of psilocybin. Data were pooled and analyzed from five laboratory experiments in which participants (n=184) received a moderate to high oral dose of psilocybin (at least 20 mg/70 kg). Results of confirmatory factor analysis demonstrate the reliability and internal validity of the MEQ30. Structural equation models demonstrate the external and convergent validity of the MEQ30 by showing that latent variable scores on the MEQ30 positively predict persisting change in attitudes, behavior, and well-being attributed to experiences with psilocybin while controlling for the contribution of the participant-rated intensity of drug effects. These findings support the use of the MEQ30 as an efficient measure of individual mystical experiences. A method to score a "complete mystical experience" that was used in previous versions of the mystical experience questionnaire is validated in the MEQ30, and a stand-alone version of the MEQ30 is provided for use in future research. © The Author(s) 2015.

  12. The Dynamic Similitude Design Method of Thin Walled Structures and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Zhong Luo

    2016-01-01

    Full Text Available For the applicability of dynamic similitude models of thin walled structures, such as engine blades, turbine discs, and cylindrical shells, the dynamic similitude design of typical thin walled structures is investigated. The governing equation of typical thin walled structures is firstly unified, which guides to establishing dynamic scaling laws of typical thin walled structures. Based on the governing equation, geometrically complete scaling law of the typical thin walled structure is derived. In order to determine accurate distorted scaling laws of typical thin walled structures, three principles are proposed and theoretically proved by combining the sensitivity analysis and governing equation. Taking the thin walled annular plate as an example, geometrically complete and distorted scaling laws can be obtained based on the principles of determining dynamic scaling laws. Furthermore, the previous five orders’ accurate distorted scaling laws of thin walled annular plates are presented and numerically validated. Finally, the effectiveness of the similitude design method is validated by experimental annular plates.

  13. Fuel model Validation in the TASS/SMR-S code by Comparing with Experimental Results

    Energy Technology Data Exchange (ETDEWEB)

    Ahn, Sang Jun; Yang, Soo Hyung; Chung, Young Jong; Lee, Won Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2011-05-15

    An advanced integral pressurized water reactor, SMART (System-Integrated Modular Advanced ReacTor) has been developed by KAERI (Korea Atomic Energy Research and Institute). For the purpose of an electric power generation and seawater desalination by using nuclear energy, SMART has been developed by KAERI (KAERI, 2010). For the safety evaluation and performance analysis of the SMART, TASS/SMR-S (Transient And Setpoint Simulation/System- integrated Modular Reactor) code, has been developed. In this paper, the gap conductance model for the calculation of gap conductance has been validated by using experimental results. In the validation, the behaviors of fuel temperature and off-center temperature are selected as the major parameters

  14. Experimental Validation and Model Verification for a Novel Geometry ICPC Solar Collector

    DEFF Research Database (Denmark)

    Perers, Bengt; Duff, William S.; Daosukho, Jirachote

    A novel geometry ICPC solar collector was developed at the University of Chicago and Colorado State University. A ray tracing model has been designed to investigate the optical performance of both the horizontal and vertical fin versions of this collector. Solar radiation is modeled as discrete...... to the desired incident angle of the sun’s rays, performance of the novel ICPC solar collector at various specified angles along the transverse and longitudinal evacuated tube directions were experimentally determined. To validate the ray tracing model, transverse and longitudinal performance predictions...... at the corresponding specified incident angles are compared to the Sandia results. A 100 m2 336 Novel ICPC evacuated tube solar collector array has been in continuous operation at a demonstration project in Sacramento California since 1998. Data from the initial operation of the array are used to further validate...

  15. Experimental validation of error in temperature measurements in thin walled ductile iron castings

    DEFF Research Database (Denmark)

    Pedersen, Karl Martin; Tiedje, Niels Skat

    2007-01-01

    An experimental analysis has been performed to validate the measurement error of cooling curves measured in thin walled ductile cast iron. Specially designed thermocouples with Ø0.2 mm thermocouple wire in Ø1.6 mm ceramic tube was used for the experiments. Temperatures were measured in plates...... to a level about 20C lower than the actual temperature in the casting. Factors affecting the measurement error (oxide layer on the thermocouple wire, penetration into the ceramic tube and variation in placement of thermocouple) are discussed. Finally, it is shown how useful cooling curve may be obtained...

  16. Online Energy Management Systems for Microgrids: Experimental Validation and Assessment Framework

    DEFF Research Database (Denmark)

    Hernández, Adriana Carolina Luna; Meng, Lexuan; Aldana, Nelson Leonardo Diaz

    2018-01-01

    framework for quantitatively assess the enhancement attained by different online energy management strategies. The proposed architecture allows the interaction of measurement, forecasting and optimization modules, in which a generic generation-side mathematical problem is modeled, aiming to minimize...... applicable for specific case studies rather than in generic architectures that can deal with the uncertainties of the renewable energy sources. This paper contributes a design and experimental validation of an adaptable energy management system implemented in an online scheme, as well as an evaluation...

  17. Experimental investigations and validation of two dimensional model for multistream plate fin heat exchangers

    Science.gov (United States)

    Goyal, Mukesh; Chakravarty, Anindya; Atrey, M. D.

    2017-03-01

    Experimental investigations are carried out using a specially developed three-layer plate fin heat exchanger (PFHE), with helium as the working fluid cooled to cryogenic temperatures using liquid nitrogen (LN2) as a coolant. These results are used for validation of an already proposed and reported numerical model based on finite volume analysis for multistream (MS) plate fin heat exchangers (PFHE) for cryogenic applications (Goyal et al., 2014). The results from the experiments are presented and a reasonable agreement is observed with the already reported numerical model.

  18. Experimental Validation of a Novel Compact Focusing Scheme for Future Energy-Frontier Linear Lepton Colliders

    Science.gov (United States)

    White, G. R.; Ainsworth, R.; Akagi, T.; Alabau-Gonzalvo, J.; Angal-Kalinin, D.; Araki, S.; Aryshev, A.; Bai, S.; Bambade, P.; Bett, D. R.; Blair, G.; Blanch, C.; Blanco, O.; Blaskovic-Kraljevic, N.; Bolzon, B.; Boogert, S.; Burrows, P. N.; Christian, G.; Corner, L.; Davis, M. R.; Faus-Golfe, A.; Fukuda, M.; Gao, J.; García-Morales, H.; Geffroy, N.; Hayano, H.; Heo, A. Y.; Hildreth, M.; Honda, Y.; Huang, J. Y.; Hwang, W. H.; Iwashita, Y.; Jang, S.; Jeremie, A.; Kamiya, Y.; Karataev, P.; Kim, E. S.; Kim, H. S.; Kim, S. H.; Kim, Y. I.; Komamiya, S.; Kubo, K.; Kume, T.; Kuroda, S.; Lam, B.; Lekomtsev, K.; Liu, S.; Lyapin, A.; Marin, E.; Masuzawa, M.; McCormick, D.; Naito, T.; Nelson, J.; Nevay, L. J.; Okugi, T.; Omori, T.; Oroku, M.; Park, H.; Park, Y. J.; Perry, C.; Pfingstner, J.; Phinney, N.; Rawankar, A.; Renier, Y.; Resta-López, J.; Ross, M.; Sanuki, T.; Schulte, D.; Seryi, A.; Shevelev, M.; Shimizu, H.; Snuverink, J.; Spencer, C.; Suehara, T.; Sugahara, R.; Takahashi, T.; Tanaka, R.; Tauchi, T.; Terunuma, N.; Tomás, R.; Urakawa, J.; Wang, D.; Warden, M.; Wendt, M.; Wolski, A.; Woodley, M.; Yamaguchi, Y.; Yamanaka, T.; Yan, J.; Yokoya, K.; Zimmermann, F.; ATF2 Collaboration

    2014-01-01

    A novel scheme for the focusing of high-energy leptons in future linear colliders was proposed in 2001 [P. Raimondi and A. Seryi, Phys. Rev. Lett. 86, 3779 (2001)]. This scheme has many advantageous properties over previously studied focusing schemes, including being significantly shorter for a given energy and having a significantly better energy bandwidth. Experimental results from the ATF2 accelerator at KEK are presented that validate the operating principle of such a scheme by demonstrating the demagnification of a 1.3 GeV electron beam down to below 65 nm in height using an energy-scaled version of the compact focusing optics designed for the ILC collider.

  19. Analytical and experimental validation of the Oblique Detonation Wave Engine concept

    Science.gov (United States)

    Adelman, Henry G.; Cambier, Jean-Luc; Menees, Gene P.; Balboni, John A.

    1988-01-01

    The Oblique Detonation Wave Engine (ODWE) for hypersonic flight has been analytically studied by NASA using the CFD codes which fully couple finite rate chemistry with fluid dynamics. Fuel injector designs investigated included wall and strut injectors, and the in-stream strut injectors were chosen to provide good mixing with minimal stagnation pressure losses. Plans for experimentally validating the ODWE concept in an arc-jet hypersonic wind tunnel are discussed. Measurements of the flow field properties behind the oblique wave will be compared to analytical predictions.

  20. Experimental Testing Procedures and Dynamic Model Validation for Vanadium Redox Flow Battery Storage System

    DEFF Research Database (Denmark)

    Baccino, Francesco; Marinelli, Mattia; Nørgård, Per Bromand

    2013-01-01

    The paper aims at characterizing the electrochemical and thermal parameters of a 15 kW/320 kWh vanadium redox flow battery (VRB) installed in the SYSLAB test facility of the DTU Risø Campus and experimentally validating the proposed dynamic model realized in Matlab-Simulink. The adopted testing...... procedure consists of analyzing the voltage and current values during a power reference step-response and evaluating the relevant electrochemical parameters such as the internal resistance. The results of different tests are presented and used to define the electrical characteristics and the overall...

  1. Modeling and experimental validation of water mass balance in a PEM fuel cell stack

    DEFF Research Database (Denmark)

    Liso, Vincenzo; Araya, Samuel Simon; Olesen, Anders Christian

    2016-01-01

    management in PEM fuel cell is crucial in order to avoid an imbalance between water production and water removal from the fuel cell. In the present study, a novel mathematical zero-dimensional model has been formulated for the water mass balance and hydration of a polymer electrolyte membrane. This model...... is validated against experimental data. In the results it is shown that the fuel cell water balance calculated by this model shows better fit with experimental data-points compared with model where only steady state operation were considered. We conclude that this discrepancy is due a different rate of water......Polymer electrolyte membrane (PEM) fuel cells require good hydration in order to deliver high performance and ensure long life operation. Water is essential for proton conductivity in the membrane which increases by nearly six orders of magnitude from dry to fully hydrated. Adequate water...

  2. Experimental validation of systematically designed acoustic hyperbolic meta material slab exhibiting negative refraction

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Sigmund, Ole

    2016-01-01

    This Letter reports on the experimental validation of a two-dimensional acoustic hyperbolic metamaterial slab optimized to exhibit negative refractive behavior. The slab was designed using a topology optimization based systematic design method allowing for tailoring the refractive behavior....... The experimental results confirm the predicted refractive capability as well as the predicted transmission at an interface. The study simultaneously provides an estimate of the attenuation inside the slab stemming from the boundary layer effects—insight which can be utilized in the further design...... of the metamaterial slabs. The capability of tailoring the refractive behavior opens possibilities for different applications. For instance, a slab exhibiting zero refraction across a wide angular range is capable of funneling acoustic energy through it, while a material exhibiting the negative refractive behavior...

  3. Calculation and Experimental Validation of Pressure and Temperature Effects on COG-Air Fuel Mixtures

    Directory of Open Access Journals (Sweden)

    Jan Skrinsky

    2018-01-01

    Full Text Available COG have been widely used together with blast furnace gas and blast furnace oxygen gas in the steel industry in Moravian-Silesian region of Czech Republic. COG is a flammable and explosive substance. Most explosion characteristics published so far are valid for pure compounds and limited experimental conditions, mostly ambient. There have been no explosion characteristic exists for COG-air mixtures which cover industrial conditions up to 423 K. Experimental tests have been carried out in a 20-L closed explosion chamber adopted for the explosion tests. The element potential approach in the thermochemical equilibrium calculations applied in the Chemkin subroutine has been used for explosion pressure calculations. Different explosion characteristics have been reported in a range from 298 K up to 423 K and from 0.5 bar(a up to 1.0 bar(a.

  4. Experimental validation of sound field control with a circular double-layer array of loudspeakers

    DEFF Research Database (Denmark)

    Chang, Jiho; Jacobsen, Finn

    2013-01-01

    This paper is concerned with experimental validation of a recently proposed method of controlling sound fields with a circular double-layer array of loudspeakers [Chang and Jacobsen, J. Acoust. Soc. Am. 131(6), 4518-4525 (2012)]. The double-layer of loudspeakers is realized with 20 pairs of closed......-box loudspeakers mounted back-to-back. Source strengths are obtained with several solution methods by modeling loudspeakers as a weighted combination of monopoles and dipoles. Sound pressure levels of the controlled sound fields are measured inside and outside the array in an anechoic room, and performance indices...... are calculated. The experimental results show that a method of combining pure contrast maximization with a pressure matching technique provides only a small error in the listening zone between the desired and the reproduced fields, and at the same time reduces the sound level in the quiet zone as expected...

  5. China Energy Primer

    Energy Technology Data Exchange (ETDEWEB)

    Ni, Chun Chun

    2009-11-16

    Based on extensive analysis of the 'China Energy Databook Version 7' (October 2008) this Primer for China's Energy Industry draws a broad picture of China's energy industry with the two goals of helping users read and interpret the data presented in the 'China Energy Databook' and understand the historical evolution of China's energy inustry. Primer provides comprehensive historical reviews of China's energy industry including its supply and demand, exports and imports, investments, environment, and most importantly, its complicated pricing system, a key element in the analysis of China's energy sector.

  6. De novo peptide design and experimental validation of histone methyltransferase inhibitors.

    Directory of Open Access Journals (Sweden)

    James Smadbeck

    Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA-protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 [Formula: see text]M, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly

  7. De novo peptide design and experimental validation of histone methyltransferase inhibitors.

    Directory of Open Access Journals (Sweden)

    James Smadbeck

    Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 mM, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly inhibit EZH2

  8. Experimentally Manipulating Items Informs on the (Limited) Construct and Criterion Validity of the Humor Styles Questionnaire.

    Science.gov (United States)

    Ruch, Willibald; Heintz, Sonja

    2017-01-01

    How strongly does humor (i.e., the construct-relevant content) in the Humor Styles Questionnaire (HSQ; Martin et al., 2003) determine the responses to this measure (i.e., construct validity)? Also, how much does humor influence the relationships of the four HSQ scales, namely affiliative, self-enhancing, aggressive, and self-defeating, with personality traits and subjective well-being (i.e., criterion validity)? The present paper answers these two questions by experimentally manipulating the 32 items of the HSQ to only (or mostly) contain humor (i.e., construct-relevant content) or to substitute the humor content with non-humorous alternatives (i.e., only assessing construct-irrelevant context). Study 1 (N = 187) showed that the HSQ affiliative scale was mainly determined by humor, self-enhancing and aggressive were determined by both humor and non-humorous context, and self-defeating was primarily determined by the context. This suggests that humor is not the primary source of the variance in three of the HQS scales, thereby limiting their construct validity. Study 2 (N = 261) showed that the relationships of the HSQ scales to the Big Five personality traits and subjective well-being (positive affect, negative affect, and life satisfaction) were consistently reduced (personality) or vanished (subjective well-being) when the non-humorous contexts in the HSQ items were controlled for. For the HSQ self-defeating scale, the pattern of relationships to personality was also altered, supporting an positive rather than a negative view of the humor in this humor style. The present findings thus call for a reevaluation of the role that humor plays in the HSQ (construct validity) and in the relationships to personality and well-being (criterion validity).

  9. Theoretical and experimental validation of evacuated tubes directly coupled with solar still

    Science.gov (United States)

    Panchal, H. N.; Thakkar, H.

    2016-11-01

    Experimental study of evacuated tubes coupled solar still in the climatic conditions of Mehsana, a region of North Gujarat, India during summer and winter climate conditions has been made. Experimental setup was made by authors. Fourteen double-walled hard borosilicate glass tubes have been used. Evacuated tubes were inclined at angle of 45° from horizontal. Outer tubes of evacuated tubes were transparent, inner tubes were coated with a selective coating of Al-Ni/Al compound for better solar radiation absorption and minimum emittance. It has been shown that evacuated tube attachments to the solar still increased the water temperature inside the solar still for increment in the generation of distillate output. Evacuated tubes coupled solar still is not only produce distilled water during sunshine hours, but also off-sunshine hours due to heat storage effect. For the validation of the experimental results, a theoretical model is proposed based on the fundamentals of heat and mass transfer equations for solar still glass cover, water in basin and basin bottom. Two main statistical parameters—root mean square error and mean bias error—were calculated to compare the results of experiments and theoretical analysis. Closed matching of the experimental and theoretical results has been found.

  10. Using experimental human influenza infections to validate a viral dynamic model and the implications for prediction.

    Science.gov (United States)

    Chen, S C; You, S H; Liu, C Y; Chio, C P; Liao, C M

    2012-09-01

    The aim of this work was to use experimental infection data of human influenza to assess a simple viral dynamics model in epithelial cells and better understand the underlying complex factors governing the infection process. The developed study model expands on previous reports of a target cell-limited model with delayed virus production. Data from 10 published experimental infection studies of human influenza was used to validate the model. Our results elucidate, mechanistically, the associations between epithelial cells, human immune responses, and viral titres and were supported by the experimental infection data. We report that the maximum total number of free virions following infection is 10(3)-fold higher than the initial introduced titre. Our results indicated that the infection rates of unprotected epithelial cells probably play an important role in affecting viral dynamics. By simulating an advanced model of viral dynamics and applying it to experimental infection data of human influenza, we obtained important estimates of the infection rate. This work provides epidemiologically meaningful results, meriting further efforts to understand the causes and consequences of influenza A infection.

  11. Computational Modelling of Patella Femoral Kinematics During Gait Cycle and Experimental Validation

    Science.gov (United States)

    Maiti, Raman

    2016-06-01

    The effect of loading and boundary conditions on patellar mechanics is significant due to the complications arising in patella femoral joints during total knee replacements. To understand the patellar mechanics with respect to loading and motion, a computational model representing the patella femoral joint was developed and validated against experimental results. The computational model was created in IDEAS NX and simulated in MSC ADAMS/VIEW software. The results obtained in the form of internal external rotations and anterior posterior displacements for a new and experimentally simulated specimen for patella femoral joint under standard gait condition were compared with experimental measurements performed on the Leeds ProSim knee simulator. A good overall agreement between the computational prediction and the experimental data was obtained for patella femoral kinematics. Good agreement between the model and the past studies was observed when the ligament load was removed and the medial lateral displacement was constrained. The model is sensitive to ±5 % change in kinematics, frictional, force and stiffness coefficients and insensitive to time step.

  12. Experimental approach to validation of an analytical and numerical thermal analysis of a travelling wave tube

    Science.gov (United States)

    Wiejak, W.; Wymysłowski, A.

    2016-01-01

    Travelling Wave Tube (TWT) is an electronic vacuum microwave device, which is used as a high power microwave amplifier, mainly in telecommunication purposes, e.g. radar systems. TWT's is an alternative solution in comparison to semiconductor devices in case of high power and high frequency applications. Thermal behaviour of TWT is one of the key aspects influencing its reliability and working parameters. The main goal of the research was to perform analytical, experimental and numerical analysis of a temperature distribution of a low band TWT in case of a typical working condition. Because the theoretical analysis seems to be very complex thus it was decided to compare the experimental results with the numerical simulations as well as with the simplified analytical formulas. As a first step of the presented research, the analytical analysis and numerical modelling of the helix TWT was carried out. The objective of the thermal analysis was to assess the temperature distribution in different parts of the helix TWT assembly during the extreme standard and working conditions. As a second stage of the research the numerical results were validated by the experimental measurements, which were carried out using a specially designed TWT test samples and corresponding experimental measurement tools.

  13. Development and validation of experimental protocols for use of cardinal models for prediction of microorganisms growth in food products

    NARCIS (Netherlands)

    Pinon, A.; Zwietering, M.H.; Perrier, L.; Membré, J.M.; Leporq, B.; Mettler, E.; Thuault, D.; Coroller, L.; Stahl, V.; Vialette, M.

    2004-01-01

    An experimental protocol to validate secondary-model application to foods was suggested. Escherichia coli, Listeria monocytogenes, Bacillus cereus, Clostridium perfringens, and Salmonella were observed in various food categories, such as meat, dairy, egg, or seafood products. The secondary model

  14. Validation of experimental whole-body SAR assessment method in a complex indoor environment.

    Science.gov (United States)

    Bamba, Aliou; Joseph, Wout; Vermeeren, Gunter; Tanghe, Emmeric; Gaillot, Davy Paul; Andersen, Jørgen B; Nielsen, Jesper Ødum; Lienard, Martine; Martens, Luc

    2013-02-01

    Experimentally assessing the whole-body specific absorption rate (SAR(wb) ) in a complex indoor environment is very challenging. An experimental method based on room electromagnetics theory (accounting only the line-of-sight as specular path) is validated using numerical simulations with the finite-difference time-domain method. Furthermore, the method accounts for diffuse multipath components (DMC) in the total absorption rate by considering the reverberation time of the investigated room, which describes all the losses in a complex indoor environment. The advantage of the proposed method is that it allows discarding the computational burden because it does not use any discretizations. Results show good agreement between measurement and computation at 2.8 GHz, as long as the plane wave assumption is valid, that is, at large distances from the transmitter. Relative deviations of 0.71% and 4% have been obtained for far-field scenarios, and 77.5% for the near field-scenario. The contribution of the DMC in the total absorption rate is also quantified here, which has never been investigated before. It is found that the DMC may represent an important part of the total absorption rate; its contribution may reach up to 90% for certain scenarios in an indoor environment. Copyright © 2012 Wiley Periodicals, Inc.

  15. CFD Code Validation against Stratified Air-Water Flow Experimental Data

    Directory of Open Access Journals (Sweden)

    F. Terzuoli

    2008-01-01

    Full Text Available Pressurized thermal shock (PTS modelling has been identified as one of the most important industrial needs related to nuclear reactor safety. A severe PTS scenario limiting the reactor pressure vessel (RPV lifetime is the cold water emergency core cooling (ECC injection into the cold leg during a loss of coolant accident (LOCA. Since it represents a big challenge for numerical simulations, this scenario was selected within the European Platform for Nuclear Reactor Simulations (NURESIM Integrated Project as a reference two-phase problem for computational fluid dynamics (CFDs code validation. This paper presents a CFD analysis of a stratified air-water flow experimental investigation performed at the Institut de Mécanique des Fluides de Toulouse in 1985, which shares some common physical features with the ECC injection in PWR cold leg. Numerical simulations have been carried out with two commercial codes (Fluent and Ansys CFX, and a research code (NEPTUNE CFD. The aim of this work, carried out at the University of Pisa within the NURESIM IP, is to validate the free surface flow model implemented in the codes against experimental data, and to perform code-to-code benchmarking. Obtained results suggest the relevance of three-dimensional effects and stress the importance of a suitable interface drag modelling.

  16. Experimental and computational validation of BDTPS using a heterogeneous boron phantom

    Energy Technology Data Exchange (ETDEWEB)

    Daquino, G.G. E-mail: giuseppe.daquino@cern.chdaquino@supereva.it; Cerullo, N.; Mazzini, M.; Moss, R.L.; Muzi, L

    2004-11-01

    The idea to couple the treatment planning system (TPS) to the information on the real boron distribution in the patient acquired by positron emission tomography (PET) is the main added value of the new methodology set-up at DIMNP (Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione) of University of Pisa, in collaboration with the JRC (Joint Research Centre) at Petten (NL). This methodology has been implemented in a new TPS, called Boron Distribution Treatment Planning System (BDTPS), which takes into account the actual boron distribution in the patient's organ, as opposed to other TPSs used in BNCT that assume an ideal uniform boron distribution. BDTPS is based on the Monte Carlo technique and has been experimentally validated comparing the computed main parameters (thermal neutron flux, boron dose, etc.) to those measured during the irradiation of an ad hoc designed phantom (HEterogeneous BOron phantoM, HEBOM). The results are also in good agreement with those obtained by the standard TPS SERA and by reference calculations carried out using an analytical model with the MCNP code. In this paper, the methodology followed for both the experimental and the computational validation of BDTPS is described.

  17. Model Development and Experimental Validation of the Fusible Heat Sink Design for Exploration Vehicles

    Science.gov (United States)

    Cognata, Thomas J.; Leimkuehler, Thomas; Sheth, Rubik; Le, Hung

    2013-01-01

    The Fusible Heat Sink is a novel vehicle heat rejection technology which combines a flow through radiator with a phase change material. The combined technologies create a multi-function device able to shield crew members against Solar Particle Events (SPE), reduce radiator extent by permitting sizing to the average vehicle heat load rather than to the peak vehicle heat load, and to substantially absorb heat load excursions from the average while constantly maintaining thermal control system setpoints. This multi-function technology provides great flexibility for mission planning, making it possible to operate a vehicle in hot or cold environments and under high or low heat load conditions for extended periods of time. This paper describes the modeling and experimental validation of the Fusible Heat Sink technology. The model developed was intended to meet the radiation and heat rejection requirements of a nominal MMSEV mission. Development parameters and results, including sizing and model performance will be discussed. From this flight-sized model, a scaled test-article design was modeled, designed, and fabricated for experimental validation of the technology at Johnson Space Center thermal vacuum chamber facilities. Testing showed performance comparable to the model at nominal loads and the capability to maintain heat loads substantially greater than nominal for extended periods of time.

  18. Virtual Reality for Enhanced Ecological Validity and Experimental Control in the Clinical, Affective and Social Neurosciences

    Science.gov (United States)

    Parsons, Thomas D.

    2015-01-01

    An essential tension can be found between researchers interested in ecological validity and those concerned with maintaining experimental control. Research in the human neurosciences often involves the use of simple and static stimuli lacking many of the potentially important aspects of real world activities and interactions. While this research is valuable, there is a growing interest in the human neurosciences to use cues about target states in the real world via multimodal scenarios that involve visual, semantic, and prosodic information. These scenarios should include dynamic stimuli presented concurrently or serially in a manner that allows researchers to assess the integrative processes carried out by perceivers over time. Furthermore, there is growing interest in contextually embedded stimuli that can constrain participant interpretations of cues about a target’s internal states. Virtual reality environments proffer assessment paradigms that combine the experimental control of laboratory measures with emotionally engaging background narratives to enhance affective experience and social interactions. The present review highlights the potential of virtual reality environments for enhanced ecological validity in the clinical, affective, and social neurosciences. PMID:26696869

  19. Experimental Validation of a Cardiac Simulator for in vitro Evaluation of Prosthetic Heart Valves

    Directory of Open Access Journals (Sweden)

    Ovandir Bazan

    Full Text Available Abstract Objective: This work describes the experimental validation of a cardiac simulator for three heart rates (60, 80 and 100 beats per minute, under physiological conditions, as a suitable environment for prosthetic heart valves testing in the mitral or aortic position. Methods: In the experiment, an aortic bileaflet mechanical valve and a mitral bioprosthesis were employed in the left ventricular model. A test fluid of 47.6% by volume of glycerin solution in water at 36.5ºC was used as blood analogue fluid. A supervisory control and data acquisition system implemented previously in LabVIEW was applied to induce the ventricular operation and to acquire the ventricular signals. The parameters of the left ventricular model operation were based on in vivo and in vitro data. The waves of ventricular and systemic pressures, aortic flow, stroke volume, among others, were acquired while manual adjustments in the arterial impedance model were also established. Results: The acquired waves showed good results concerning some in vivo data and requirements from the ISO 5840 standard. Conclusion: The experimental validation was performed, allowing, in future studies, characterizing the hydrodynamic performance of prosthetic heart valves.

  20. Finite difference analysis and experimental validation of 3D photonic crystals for structural health monitoring

    Science.gov (United States)

    Piccolo, Valentina; Chiappini, Andrea; Vaccari, Alessandro; Calà Lesina, Antonino; Ferrari, Maurizio; Deseri, Luca; Perry, Marcus; Zonta, Daniele

    2017-04-01

    In this work, we validate the behavior of 3D Photonic Crystals for Structural Health Monitoring applications. A Finite Difference Time Domain (FDTD) analysis has been performed and compared to experimental data. We demonstrate that the photonic properties of a crystal (comprised of sub-micrometric polystyrene colloidal spheres embedded in a PDMS matrix) change as a function of the axial strain applied to a rubber substrate. The change in the reflected wavelength, detected through our laboratory experiments and equivalent to a visible change in crystal color, is assumed to be caused by changes in the interplanar spacing of the polystyrene beads. This behavior is captured by our full wave 3D FDTD model. This contains different wavelengths in the visible spectrum and the wave amplitudes of the reflected and transmitted secondary beams are then computed. A change in the reflectance or transmittance is observed at every programmed step in which we vary the distance between the spheres. These investigations are an important tool to predict, study and validate our understanding of the behavior of this highly complex physical system. In this context, we have developed a versatile and robust parallelized code, able to numerically model the interaction of light with matter, by directly solving Maxwell's equations in their strong form. The ability to describe the physical behavior of such systems is an important and fundamental capability which will aid the design and validation of innovative photonic sensors.

  1. Semantic Web Primer

    NARCIS (Netherlands)

    Antoniou, Grigoris; Harmelen, Frank van

    2004-01-01

    The development of the Semantic Web, with machine-readable content, has the potential to revolutionize the World Wide Web and its use. A Semantic Web Primer provides an introduction and guide to this still emerging field, describing its key ideas, languages, and technologies. Suitable for use as a

  2. Identification of ISSR Primers

    African Journals Online (AJOL)

    leaf preferred by consumers. These genotypes ... plants, primers that work for one may not work for another. Hence .... Naidoo, Madhupa and Dr Bayo Shittu for access to laboratory facilities, training in different techniques and editing of manuscript. This work was made possible by a fellowship for Female. Academic Staff ...

  3. Experimental Validation of a Differential Variational Inequality-Based Approach for Handling Friction and Contact in Vehicle

    Science.gov (United States)

    2015-11-20

    terrain modeled using the discrete element method (DEM). Experimental Validation of a Differential Variational Inequality -Based Approach for Handling...COVERED 00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Experimental Validation of a Differential Variational Inequality -Based Approach for...sinkage, and single wheel tests. 1.1. Modeling Frictional Contact Via Differential Variational Inequalities Consider a three dimensional (3D) system of

  4. An iterative method for selecting degenerate multiplex PCR primers.

    Science.gov (United States)

    Souvenir, Richard; Buhler, Jeremy; Stormo, Gary; Zhang, Weixiong

    2007-01-01

    Single-nucleotide polymorphism (SNP) genotyping is an important molecular genetics process, which can produce results that will be useful in the medical field. Because of inherent complexities in DNA manipulation and analysis, many different methods have been proposed for a standard assay. One of the proposed techniques for performing SNP genotyping requires amplifying regions of DNA surrounding a large number of SNP loci. To automate a portion of this particular method, it is necessary to select a set of primers for the experiment. Selecting these primers can be formulated as the Multiple Degenerate Primer Design (MDPD) problem. The Multiple, Iterative Primer Selector (MIPS) is an iterative beam-search algorithm for MDPD. Theoretical and experimental analyses show that this algorithm performs well compared with the limits of degenerate primer design. Furthermore, MIPS outperforms an existing algorithm that was designed for a related degenerate primer selection problem.

  5. Experimental Validation of Stratified Flow Phenomena, Graphite Oxidation, and Mitigation Strategies of Air Ingress Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Chang Ho Oh; Eung Soo Kim; Hee Cheon No; Nam Zin Cho

    2008-12-01

    The US Department of Energy is performing research and development (R&D) that focuses on key phenomena that are important during challenging scenarios that may occur in the Next Generation Nuclear Plant (NGNP) Program / GEN-IV Very High Temperature Reactor (VHTR). Phenomena identification and ranking studies (PIRT) to date have identified the air ingress event, following on the heels of a VHTR depressurization, as very important (Schultz et al., 2006). Consequently, the development of advanced air ingress-related models and verification and validation (V&V) are very high priority for the NGNP program. Following a loss of coolant and system depressurization, air will enter the core through the break. Air ingress leads to oxidation of the in-core graphite structure and fuel. The oxidation will accelerate heat-up of the bottom reflector and the reactor core and will cause the release of fission products eventually. The potential collapse of the bottom reflector because of burn-off and the release of CO lead to serious safety problems. For estimation of the proper safety margin we need experimental data and tools, including accurate multi-dimensional thermal-hydraulic and reactor physics models, a burn-off model, and a fracture model. We also need to develop effective strategies to mitigate the effects of oxidation. The results from this research will provide crucial inputs to the INL NGNP/VHTR Methods R&D project. This project is focused on (a) analytical and experimental study of air ingress caused by density-driven, stratified, countercurrent flow, (b) advanced graphite oxidation experiments, (c) experimental study of burn-off in the bottom reflector, (d) structural tests of the burnt-off bottom reflector, (e) implementation of advanced models developed during the previous tasks into the GAMMA code, (f) full air ingress and oxidation mitigation analyses, (g) development of core neutronic models, (h) coupling of the core neutronic and thermal hydraulic models, and (i

  6. Effects of human running cadence and experimental validation of the bouncing ball model

    Science.gov (United States)

    Bencsik, László; Zelei, Ambrus

    2017-05-01

    The biomechanical analysis of human running is a complex problem, because of the large number of parameters and degrees of freedom. However, simplified models can be constructed, which are usually characterized by some fundamental parameters, like step length, foot strike pattern and cadence. The bouncing ball model of human running is analysed theoretically and experimentally in this work. It is a minimally complex dynamic model when the aim is to estimate the energy cost of running and the tendency of ground-foot impact intensity as a function of cadence. The model shows that cadence has a direct effect on energy efficiency of running and ground-foot impact intensity. Furthermore, it shows that higher cadence implies lower risk of injury and better energy efficiency. An experimental data collection of 121 amateur runners is presented. The experimental results validate the model and provides information about the walk-to-run transition speed and the typical development of cadence and grounded phase ratio in different running speed ranges.

  7. Validation of an experimental polyurethane model for biomechanical studies on implant supported prosthesis - tension tests

    Directory of Open Access Journals (Sweden)

    Mariane Miyashiro

    2011-06-01

    Full Text Available OBJECTIVES: The complexity and heterogeneity of human bone, as well as ethical issues, frequently hinder the development of clinical trials. The purpose of this in vitro study was to determine the modulus of elasticity of a polyurethane isotropic experimental model via tension tests, comparing the results to those reported in the literature for mandibular bone, in order to validate the use of such a model in lieu of mandibular bone in biomechanical studies. MATERIAL AND METHODS: Forty-five polyurethane test specimens were divided into 3 groups of 15 specimens each, according to the ratio (A/B of polyurethane reagents (PU-1: 1/0.5, PU-2: 1/1, PU-3: 1/1.5. RESULTS: Tension tests were performed in each experimental group and the modulus of elasticity values found were 192.98 MPa (SD=57.20 for PU-1, 347.90 MPa (SD=109.54 for PU-2 and 304.64 MPa (SD=25.48 for PU-3. CONCLUSION: The concentration of choice for building the experimental model was 1/1.

  8. VALIDATION OF CFD PREDICTIONS OF FLOW IN A 3D ALVEOLATED BEND WITH EXPERIMENTAL DATA

    Science.gov (United States)

    VAN ERTBRUGGEN, C.; CORIERI, P.; THEUNISSEN, R.; RIETHMULLER, M.L.; DARQUENNE, C.

    2008-01-01

    Verifying numerical predictions with experimental data is an important aspect of any modeling studies. In the case of the lung, the absence of direct in-vivo flow measurements makes such verification almost impossible. We performed computational fluid dynamics (CFD) simulations in a 3D scaled-up model of an alveolated bend with rigid walls that incorporated essential geometrical characteristics of human alveolar structures and compared numerical predictions with experimental flow measurements made in the same model by Particle Image Velocimetry (PIV). Flow in both models was representative of acinar flow during normal breathing (0.82 ml/s). The experimental model was built in silicone and silicone oil was used as the carrier fluid. Flow measurements were obtained by an ensemble averaging procedure. CFD simulation was performed with STAR-CCM+ (CD-Adapco) using a polyhedral unstructured mesh. Velocity profiles in the central duct were parabolic and no bulk convection existed between the central duct and the alveoli. Velocities inside the alveoli were ∼2 orders of magnitude smaller than the mean velocity in the central duct. CFD data agreed well with those obtained by PIV. In the central duct, data agreed within 1%. The maximum simulated velocity along the centerline of the model was 0.5% larger than measured experimentally. In the alveolar cavities, data agreed within 15% on average. This suggests that CFD techniques can satisfactorily predict acinar-type flow. Such a validation ensure a great degree of confidence in the accuracy of predictions made in more complex models of the alveolar region of the lung using similar CFD techniques. PMID:17915225

  9. ENGINEERING DESIGN OPTIMIZATION OF HEEL TESTING EQUIPMENT IN THE EXPERIMENTAL VALIDATION OF SAFE WALKING

    Directory of Open Access Journals (Sweden)

    Cristiano Fragassa

    2017-06-01

    Full Text Available Experimental test methods for the evaluation of the resistance of heels of ladies' shoes in the case of impact loads are fully defined by International Organization for Standardization (ISO procedures that indicate all the conditions of experiment. A first Standard (ISO 19553 specifies the test method for determining the strength of the heels in the case of single impact. The result offers a valuation of the liability to fail under the sporadic heavy blows. A second Standard (ISO 19556 details a method for testing the capability of heels of women' shoes to survive to the repetition of small impacts provoked by normal walking. These Standards strictly define the features for two different testing devices (with specific materials, geometries, weights, etc. and all the experimental procedures to be followed during tests. On the contrary, this paper describes the technical solutions adopted to design one single experimental device able to perform impact testing of heels in both conditions. Joining the accuracy of mechanic movements with the speed of an electronic control system, a new and flexible equipment for the complete characterization of heels respect to (single or fatigue impacts was developed. Moreover a new level of performances in experimental validation of heel resistance was introduced by the versatility of the user-defined software control programs, able to encode every complex time-depending cycle of impact loads. Dynamic simulations permitted to investigate the impacts on heel in different conditions of testing, optimizing the machine design. The complexity of real stresses on shoes during an ordinary walk and in other common situations (as going up and downstairs was considered for a proper dimensioning.

  10. Vertical footbridge vibrations: details regarding and experimental validation of the response spectrum methodology

    DEFF Research Database (Denmark)

    Ingólfsson, Einar Thór; Georgakis, Christos; Svendsen, Martin Nymann

    2008-01-01

    seismic design codes of practice. A basic outline of the methodology is given, followed by a detailed examination of the bridge-specific parameters that are applied to adjust the response obtained from a universal reference design spectrum. The bridge-specific parameters take into account key variations......In this paper, details regarding and the experimental validation of the “response spectrum” methodology for the determination of vertical footbridge response are presented. The methodology is inspired by the well-established response spectrum approach used in the majority of the world’s current...... footbridge, are presented. An accurate representation of the random crowd loading during the experiments is created through video-footage and used to theoretically predict the vertical bridge response following the response spectrum methodology. The predictions verify the effectiveness of the methodology...

  11. Final Design and Experimental Validation of the Thermal Performance of the LHC Lattice Cryostats

    CERN Document Server

    Bourcey, N; Parma, V; Poncet, A; Rohmig, P; Serio, L; Skoczen, Blazej; Tock, J P; Williams, L R

    2004-01-01

    The recent commissioning and operation of the LHC String 2 have given a first experimental validation of the global thermal performance of the LHC lattice cryostat at nominal cryogenic conditions. The cryostat designed to minimize the heat inleak from ambient temperature, houses under vacuum and thermally protects the cold mass, which contains the LHC twin-aperture superconducting magnets operating at 1.9 K in superfluid helium. Mechanical components linking the cold mass to the vacuum vessel, such as support posts and insulation vacuum barriers are designed with efficient thermalisations for heat interception to minimise heat conduction. Heat inleak by radiation is reduced by employing multilayer insulation (MLI) wrapped around the cold mass and around an aluminium thermal shield cooled to about 60 K. Measurements of the total helium vaporization rate in String 2 gives, after substraction of supplementary heat loads and end effects, an estimate of the total thermal load to a standard LHC cell (107 m) includi...

  12. Temperature-induced stresses in vacuum glazing: modelling and experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Simko, T.M.; Collins, R.E. [University of Sydney (Australia). School of Physics; Fischer-Cripps, A.C. [University of Technology, Sydney (Australia). Dept. of Applied Physics

    1998-07-01

    A temperature difference across a sample of vacuum glazing causes differential expansion of one glass sheet relative to the other. In vacuum glazing with a fused edge seal, this results in tensile and compressive stresses in the glass sheets, and bending of the structure. The physical origins of these stresses and deflections are discussed, and a finite element model is used to determine their magnitude. The model has been validated by comparison with experimental data for a well-characterised sample of vacuum glazing under accurately defined external conditions. Modelling data are presented for two glazing designs which have properties that are characteristic of the extremes of performance of this type of glazing. It is shown that mechanical edge constraints can profoundly alter the spatial distribution of stresses in the glazing. (author)

  13. Experimental validation of a numerical model for heat transfer in vacuum glazing

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Yueping; Eames, Philip C.; Hyde, Trevor J. [Centre for Sustainable Technologies, School of the Built Environment, University of Ulster, Newtownabbey, BT37 0QB, N. Ireland (United Kingdom); Norton, Brian [Dublin Institute of Technology, Aungier Street, Dublin 2 (Ireland)

    2006-05-15

    Flat vacuum glazings consisting of a narrow evacuated space between two glass panes separated by an array of small support pillars have been fabricated. A guarded hot box calorimeter was designed and constructed to measure their heat transfer coefficients. Experimental measurements of temperatures and rates of heat transfer were found to be in very good agreement with those predicted using a developed finite element model. A method for determining the heat transfer coefficient of the evacuated gap has been established and comparisons are made between the measured and predicted glass surface temperature profiles of the exposed glass area and the heat transfer coefficients of the total glazing system in order to validated the model. (author)

  14. Optimization of microalgal photobioreactor system using model predictive control with experimental validation.

    Science.gov (United States)

    Yoo, Sung Jin; Jeong, Dong Hwi; Kim, Jung Hun; Lee, Jong Min

    2016-08-01

    To maximize biomass and lipid concentrations, various optimization methods were investigated in microalgal photobioreactor systems under mixotrophic conditions. Lipid concentration was estimated using unscented Kalman filter (UKF) with other measurable sources and subsequently used as lipid data for performing model predictive control (MPC). In addition, the maximized biomass and lipid trajectory obtained by open-loop optimization were used as target trajectory for tracking by MPC. Simulation studies and experimental validation were performed and significant improvements in biomass and lipid productivity were achieved in the case where MPC was applied. However, occurence of a lag phase was observed while manipulating the feed flow rates, which is induced by large amount of inputs. This is an important phenomenon that can lead to model-plant mismatch and requires further study for the optimization of microalgal photobioreactors.

  15. A Computational Model with Experimental Validation for DNA Flow in Microchannels

    Energy Technology Data Exchange (ETDEWEB)

    Nonaka, A; Gulati, S; Trebotich, D; Miller, G H; Muller, S J; Liepmann, D

    2005-02-02

    The authors compare a computational model to experimental data for DNA-laden flow in microchannels. The purpose of this work in progress is to validate a new numerical algorithm for viscoelastic flow using the Oldroyd-B model. The numerical approach is a stable and convergent polymeric stress-splitting scheme for viscoelasticity. They treat the hyperbolic part of the equations of motion with an embedded boundary method for solving hyperbolic conservation laws in irregular domains. They enforce incompressibility and evolve velocity and pressure with a projection method. The experiments are performed using epifluorescent microscopy and digital particle image velocimetry to measure velocity fields and track the conformation of biological macromolecules. They present results comparing velocity fields and the observations of computed fluid stress on molecular conformation in various microchannels.

  16. Model development and experimental validation of a floriculture greenhouse under natural ventilation

    Energy Technology Data Exchange (ETDEWEB)

    Ganguly, A.; Ghosh, S. [Department of Mechanical Engineering, Bengal Engineering and Science University, Shibpur, Howrah 711103, West Bengal (India)

    2009-05-15

    Greenhouse technology is an effective method of cultivation of flowers, crops, etc. under controlled environment. For any greenhouse, ventilation performance is a major factor in production, influencing the yield and quality of the products. Natural ventilation can be effectively used to maintain greenhouse microclimate, conducive to plant growth, when the ambient conditions are not extreme. The present paper discusses the modeling aspects of a floriculture greenhouse suitable for operation in typical Indian climate under natural ventilation. Combined ridge and sidewall ventilation is considered in the model. The model is validated against the test results of an experimental greenhouse. Parametric analysis is also done to understand the effects of variations in parameters such as wind speed, solar radiation intensity, effective greenhouse height etc. The study reveals that the performance of a greenhouse under natural ventilation is influenced considerably by parameters such as intensity of solar radiation, effective distance between the side and the roof vents, free wind speed etc. (author)

  17. Compact infrared cryogenic wafer-level camera: design and experimental validation.

    Science.gov (United States)

    de la Barrière, Florence; Druart, Guillaume; Guérineau, Nicolas; Lasfargues, Gilles; Fendler, Manuel; Lhermet, Nicolas; Taboury, Jean

    2012-03-10

    We present a compact infrared cryogenic multichannel camera with a wide field of view equal to 120°. By merging the optics with the detector, the concept is compatible with both cryogenic constraints and wafer-level fabrication. The design strategy of such a camera is described, as well as its fabrication and integration process. Its characterization has been carried out in terms of the modulation transfer function and the noise equivalent temperature difference (NETD). The optical system is limited by the diffraction. By cooling the optics, we achieve a very low NETD equal to 15 mK compared with traditional infrared cameras. A postprocessing algorithm that aims at reconstructing a well-sampled image from the set of undersampled raw subimages produced by the camera is proposed and validated on experimental images.

  18. Experimental Validation of a Branched Solution Model for Magnetosonic Ionization Waves in Plasma Accelerators

    Science.gov (United States)

    Underwood, Thomas; Loebner, Keith; Cappelli, Mark

    2015-11-01

    Detailed measurements of the thermodynamic and electrodynamic plasma state variables within the plume of a pulsed plasma accelerator are presented. A quadruple Langmuir probe operating in current-saturation mode is used to obtain time resolved measurements of the plasma density, temperature, potential, and velocity along the central axis of the accelerator. This data is used in conjunction with a fast-framing, intensified CCD camera to develop and validate a model predicting the existence of two distinct types of ionization waves corresponding to the upper and lower solution branches of the Hugoniot curve. A deviation of less than 8% is observed between the quasi-steady, one-dimensional theoretical model and the experimentally measured plume velocity. This work is supported by the U.S. Department of Energy Stewardship Science Academic Program in addition to the National Defense Science Engineering Graduate Fellowship.

  19. Piezoelectric Actuated Phase Shifter Based on External Laser Interferometer: Design, Control and Experimental Validation.

    Science.gov (United States)

    Li, Peng-Zhi; Wang, Xiao-Dong; Sui, Yong-Xin; Zhang, De-Fu; Wang, Dong-Fang; Dong, Li-Jian; Ni, Ming-Yang

    2017-04-11

    To improve the phase-shifting accuracy, this paper presents a novel integrated framework for design, control and experimental validation of the piezoelectric actuated phase shifter with a trade-off between accuracy and cost. The piezoelectric actuators with built-in sensors are adopted to drive the double parallel four-bar linkage flexure hinge-based mechanisms. Three mechanisms form the tripod structure of the assembled phase shifter. Then, a semi-closed loop controller with inner feedback and outer feedforward loops via the external laser interferometer is developed for accurate positioning of the phase shifter. Finally, experiments related with travel range, step response, linearity and repeatability are carried out. The linearity error is 0.21% and the repeatability error of 10 μ m displacement is 3 nm. The results clearly demonstrate the good performance of the developed phase shifter and the feasibility of the proposed integrated framework.

  20. Design, Manufacturing and Experimental Validation of Optical Fiber Sensors Based Devices for Structural Health Monitoring

    Directory of Open Access Journals (Sweden)

    Angela CORICCIATI

    2016-06-01

    Full Text Available The use of optical fiber sensors is a promising and rising technique used for Structural Health Monitoring (SHM, because permit to monitor continuously the strain and the temperature of the structure where they are applied. In the present paper three different types of smart devices, that are composite materials with an optical fiber sensor embedded inside them during the manufacturing process, are described: Smart Patch, Smart Rebar and Smart Textile, which are respectively a plate for local exterior intervention, a rod for shear and flexural interior reinforcement and a textile for an external whole application. In addition to the monitoring aim, the possible additional function of these devices could be the reinforcement of the structures where they are applied. In the present work, after technology manufacturing description, the experimental laboratory characterization of each device is discussed. At last, smart devices application on medium scale masonry walls and their validation by mechanical tests is described.

  1. Numerical investigation and experimental validation of physically based advanced GTN model for DP steels

    Energy Technology Data Exchange (ETDEWEB)

    Fansi, Joseph, E-mail: jfansi@doct.ulg.ac.be [University of Liège, Departement ArGEnCo, Division MS2F, Chemin des Chevreuils 1, Liège 4000 (Belgium); Arts et Métiers ParisTech, LEM3, UMR CNRS 7239, 4 rue A. Fresnel, 57078 Metz cedex 03 (France); ArcelorMittal R and D Global Maizières S.A., voie Romaine, Maizières-Lès-Metz 57238 (France); Balan, Tudor [Arts et Métiers ParisTech, LEM3, UMR CNRS 7239, 4 rue A. Fresnel, 57078 Metz cedex 03 (France); Lemoine, Xavier [Arts et Métiers ParisTech, LEM3, UMR CNRS 7239, 4 rue A. Fresnel, 57078 Metz cedex 03 (France); ArcelorMittal R and D Global Maizières S.A., voie Romaine, Maizières-Lès-Metz 57238 (France); Maire, Eric; Landron, Caroline [INSA de Lyon, MATEIS CNRS UMR5510, 7 Avenue Jean Capelle, Villeurbanne 69621 (France); Bouaziz, Olivier [ArcelorMittal R and D Global Maizières S.A., voie Romaine, Maizières-Lès-Metz 57238 (France); Ecole des Mines de Paris, Centre des Matériaux, CNRS UMR 7633, BP 87, Evry Cedex 91003 (France); Ben Bettaieb, Mohamed [Ensicaen, 6 Boulevard du Maréchal Juin, 14050 CAEN Cedex 4 (France); Marie Habraken, Anne [University of Liège, Departement ArGEnCo, Division MS2F, Chemin des Chevreuils 1, Liège 4000 (Belgium)

    2013-05-01

    This numerical investigation of an advanced Gurson–Tvergaard–Needleman (GTN) model is an extension of the original work of Ben Bettaiebet al. (2011 [18]). The model has been implemented as a user-defined material model subroutine (VUMAT) in the Abaqus/explicit FE code. The current damage model extends the previous version by integrating the three damage mechanisms: nucleation, growth and coalescence of voids. Physically based void nucleation and growth laws are considered, including an effect of the kinematic hardening. These new contributions are based and validated on experimental results provided by high-resolution X-ray absorption tomography measurements. The current damage model is applied to predict the damage evolution and the stress state in a tensile notched specimen experiment.

  2. Servo-hydraulic actuator in controllable canonical form: Identification and experimental validation

    Science.gov (United States)

    Maghareh, Amin; Silva, Christian E.; Dyke, Shirley J.

    2018-02-01

    Hydraulic actuators have been widely used to experimentally examine structural behavior at multiple scales. Real-time hybrid simulation (RTHS) is one innovative testing method that largely relies on such servo-hydraulic actuators. In RTHS, interface conditions must be enforced in real time, and controllers are often used to achieve tracking of the desired displacements. Thus, neglecting the dynamics of hydraulic transfer system may result either in system instability or sub-optimal performance. Herein, we propose a nonlinear dynamical model for a servo-hydraulic actuator (a.k.a. hydraulic transfer system) coupled with a nonlinear physical specimen. The nonlinear dynamical model is transformed into controllable canonical form for further tracking control design purposes. Through a number of experiments, the controllable canonical model is validated.

  3. Experimental and computational validation of BDTPS using a heterogeneous boron phantom

    CERN Document Server

    Daquino, G G; Mazzini, M; Moss, R L; Muzi, L

    2004-01-01

    The idea to couple the treatment planning system (TPS) to the information on the real boron distribution in the patient acquired by positron emission tomography (PET) is the main added value of the new methodology set-up at DIMNP (Dipartimento di Ingegneria Meccanica, Nucleare e della Produzione) of University of Pisa, in collaboration with the JRC (Joint Research Centre) at Petten (NL). This methodology has been implemented in a new TPS, called Boron Distribution Treatment Planning System (BDTPS), which takes into account the actual boron distribution in the patient's organ, as opposed to other TPSs used in BNCT that assume an ideal uniform boron distribution. BDTPS is based on the Monte Carlo technique and has been experimentally validated comparing the computed main parameters (thermal neutron flux, boron dose, etc.) to those measured during the irradiation of an ad hoc designed phantom (HEterogeneous BOron phanto M, HEBOM). The results are also in good agreement with those obtained by the standard TPS SER...

  4. Experimental Validation of Antidiabetic Potential of Cayratia trifolia (L.) Domin: An Indigenous Medicinal Plant.

    Science.gov (United States)

    Mohammed, Shahid Iqbal; Salunkhe, Narendra Subhash; Vishwakarma, Kishor Sukhlal; Maheshwari, Vijay Laxminarayan

    2017-06-01

    The present study was undertaken to evaluate antidiabetic and antioxidant activities of Cayratia trifolia root extract against streptozotocin induced diabetes in experimental rats to scientifically validate its use against diabetes in some parts of India. Ethanolic extract, showing the highest activity in in vitro experiments, was prepared in saline and administered orally to streptozotocin induced albino Wistar diabetic rats for 21 days. Biochemical parameters liver and muscles glycogen and in vivo antioxidant activity in normal, diabetic control, standard (metformin) and treated animals were determined and compared. Attempt was made to isolate, purify and characterize one of the major secondary metabolites in extract by range of chromatographic and spectroscopic techniques. Treatment of streptozotocin induced diabetic rats with ethanolic root extract (500 mg/kg) caused significant (P compliments the antidiabetic effect.

  5. Primer on molecular genetics

    Energy Technology Data Exchange (ETDEWEB)

    1992-04-01

    This report is taken from the April 1992 draft of the DOE Human Genome 1991--1992 Program Report, which is expected to be published in May 1992. The primer is intended to be an introduction to basic principles of molecular genetics pertaining to the genome project. The material contained herein is not final and may be incomplete. Techniques of genetic mapping and DNA sequencing are described.

  6. Coal Bed Methane Primer

    Energy Technology Data Exchange (ETDEWEB)

    Dan Arthur; Bruce Langhus; Jon Seekins

    2005-05-25

    During the second half of the 1990's Coal Bed Methane (CBM) production increased dramatically nationwide to represent a significant new source of income and natural gas for many independent and established producers. Matching these soaring production rates during this period was a heightened public awareness of environmental concerns. These concerns left unexplained and under-addressed have created a significant growth in public involvement generating literally thousands of unfocused project comments for various regional NEPA efforts resulting in the delayed development of public and fee lands. The accelerating interest in CBM development coupled to the growth in public involvement has prompted the conceptualization of this project for the development of a CBM Primer. The Primer is designed to serve as a summary document, which introduces and encapsulates information pertinent to the development of Coal Bed Methane (CBM), including focused discussions of coal deposits, methane as a natural formed gas, split mineral estates, development techniques, operational issues, producing methods, applicable regulatory frameworks, land and resource management, mitigation measures, preparation of project plans, data availability, Indian Trust issues and relevant environmental technologies. An important aspect of gaining access to federal, state, tribal, or fee lands involves education of a broad array of stakeholders, including land and mineral owners, regulators, conservationists, tribal governments, special interest groups, and numerous others that could be impacted by the development of coal bed methane. Perhaps the most crucial aspect of successfully developing CBM resources is stakeholder education. Currently, an inconsistent picture of CBM exists. There is a significant lack of understanding on the parts of nearly all stakeholders, including industry, government, special interest groups, and land owners. It is envisioned the Primer would being used by a variety of

  7. Analysis of Experimental Data for High Burnup PWR Spent Fuel Isotopic Validation - Vandellos II Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Ilas, Germina [ORNL; Gauld, Ian C [ORNL

    2011-01-01

    This report is one of the several recent NUREG/CR reports documenting benchmark-quality radiochemical assay data and the use of the data to validate computer code predictions of isotopic composition for spent nuclear fuel, to establish the uncertainty and bias associated with code predictions. The experimental data analyzed in the current report were acquired from a high-burnup fuel program coordinated by Spanish organizations. The measurements included extensive actinide and fission product data of importance to spent fuel safety applications, including burnup credit, decay heat, and radiation source terms. Six unique spent fuel samples from three uranium oxide fuel rods were analyzed. The fuel rods had a 4.5 wt % {sup 235}U initial enrichment and were irradiated in the Vandellos II pressurized water reactor operated in Spain. The burnups of the fuel samples range from 42 to 78 GWd/MTU. The measurements were used to validate the two-dimensional depletion sequence TRITON in the SCALE computer code system.

  8. Experimental Validation of Depth Cameras for the Parameterization of Functional Balance of Patients in Clinical Tests

    Directory of Open Access Journals (Sweden)

    Francisco-Ángel Moreno

    2017-02-01

    Full Text Available In clinical practice, patients’ balance can be assessed using standard scales. Two of the most validated clinical tests for measuring balance are the Timed Up and Go (TUG test and the MultiDirectional Reach Test (MDRT. Nowadays, inertial sensors (IS are employed for kinematic analysis of functional tests in the clinical setting, and have become an alternative to expensive, 3D optical motion capture systems. In daily clinical practice, however, IS-based setups are yet cumbersome and inconvenient to apply. Current depth cameras have the potential for such application, presenting many advantages as, for instance, being portable, low-cost and minimally-invasive. This paper aims at experimentally validating to what extent this technology can substitute IS for the parameterization and kinematic analysis of the TUG and the MDRT tests. Twenty healthy young adults were recruited as participants to perform five different balance tests while kinematic data from their movements were measured by both a depth camera and an inertial sensor placed on their trunk. The reliability of the camera’s measurements is examined through the Interclass Correlation Coefficient (ICC, whilst the Pearson Correlation Coefficient (r is computed to evaluate the correlation between both sensor’s measurements, revealing excellent reliability and strong correlations in most cases.

  9. Model development and experimental validation of capnophilic lactic fermentation and hydrogen synthesis by Thermotoga neapolitana.

    Science.gov (United States)

    Pradhan, Nirakar; Dipasquale, Laura; d'Ippolito, Giuliana; Fontana, Angelo; Panico, Antonio; Pirozzi, Francesco; Lens, Piet N L; Esposito, Giovanni

    2016-08-01

    The aim of the present study was to develop a kinetic model for a recently proposed unique and novel metabolic process called capnophilic (CO2-requiring) lactic fermentation (CLF) pathway in Thermotoga neapolitana. The model was based on Monod kinetics and the mathematical expressions were developed to enable the simulation of biomass growth, substrate consumption and product formation. The calibrated kinetic parameters such as maximum specific uptake rate (k), semi-saturation constant (kS), biomass yield coefficient (Y) and endogenous decay rate (kd) were 1.30 h(-1), 1.42 g/L, 0.1195 and 0.0205 h(-1), respectively. A high correlation (>0.98) was obtained between the experimental data and model predictions for both model validation and cross validation processes. An increase of the lactate production in the range of 40-80% was obtained through CLF pathway compared to the classic dark fermentation model. The proposed kinetic model is the first mechanistically based model for the CLF pathway. This model provides useful information to improve the knowledge about how acetate and CO2 are recycled back by Thermotoga neapolitana to produce lactate without compromising the overall hydrogen yield. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. Supersonic, nonlinear, attached-flow wing design for high lift with experimental validation

    Science.gov (United States)

    Pittman, J. L.; Miller, D. S.; Mason, W. H.

    1984-01-01

    Results of the experimental validation are presented for the three dimensional cambered wing which was designed to achieve attached supercritical cross flow for lifting conditions typical of supersonic maneuver. The design point was a lift coefficient of 0.4 at Mach 1.62 and 12 deg angle of attack. Results from the nonlinear full potential method are presented to show the validity of the design process along with results from linear theory codes. Longitudinal force and moment data and static pressure data were obtained in the Langley Unitary Plan Wind Tunnel at Mach numbers of 1.58, 1.62, 1.66, 1.70, and 2.00 over an angle of attack range of 0 to 14 deg at a Reynolds number of 2.0 x 10 to the 6th power per foot. Oil flow photographs of the upper surface were obtained at M = 1.62 for alpha approx. = 8, 10, 12, and 14 deg.

  11. From the ideal to the real induction machine: Modelling approach and experimental validation

    Science.gov (United States)

    Bottauscio, O.; Chiampi, M.; Concari, C.; Tassoni, C.; Zucca, M.

    The aim of this paper is to discuss the ability of a numerical code in reproducing a real machine behavior, with particular reference to the cage currents of a four-poles 50 Hz induction motor. The used 2D Finite Element method (FEM) is based on voltage driven field formulation, handling the nonlinearity by the fixed point technique and the rotor movement by the sliding mesh approach. The numerical outcomes are validated by experiments performed on a dedicated laboratory setup, able to provide the instantaneous cage currents. Then, a spectral algorithm has been applied to the experimental and computed variables and the results have been interpreted in terms of magneto-motive forces. This approach allows us to determine possible machine eccentricities or other asymmetries not introduced in the simulations. Discussing the computed and measured spectra and excluding in the last ones the lines corresponding to non-idealities, an evaluation on how the modelling approach reproduces accurately the real machine is possible. The validated model will be able to reproduce the machine behavior of usual induction machines whose rotor currents are not measurable.

  12. Experimental validation of a model for diffusion-controlled absorption of organic compounds in the trachea

    Energy Technology Data Exchange (ETDEWEB)

    Gerde, P. [National Inst. for Working Life, Solna (Sweden); Muggenburg, B.A.; Thornton-Manning, J.R. [and others

    1995-12-01

    Most chemically induced lung cancer originates in the epithelial cells in the airways. Common conceptions are that chemicals deposited on the airway surface are rapidly absorbed through mucous membranes, limited primarily by the rate of blood perfusion in the mucosa. It is also commonly thought that for chemicals to induce toxicity at the site of entry, they must be either rapidly reactive, readily metabolizable, or especially toxic to the tissues at the site of entry. For highly lipophilic toxicants, there is a third option. Our mathematical model predicts that as lipophilicity increases, chemicals partition more readily into the cellular lipid membranes and diffuse more slowly through the tissues. Therefore, absorption of very lipophilic compounds will be almost entirely limited by the rate of diffusion through the epithelium rather than by perfusion of the capillary bed in the subepithelium. We have reported on a preliminary model for absorption through mucous membranes of any substance with a lipid/aqueous partition coefficient larger than one. The purpose of this work was to experimentally validate the model in Beagle dogs. This validated model on toxicant absorption in the airway mucosa will improve risk assessment of inhaled

  13. Experimental validation of a Fluid-Structure interaction model for simulating offshore floating wind turbines

    Science.gov (United States)

    Calderer, Antoni; Feist, Christ; Ruehl, Kelley; Guala, Michele; Sotiropoulos, Fotis

    2014-11-01

    A series of experiments reproducing a floating wind turbine in operational sea conditions, conducted in the St. Anthony Falls Lab. wave facility, are employed to validate the capabilities of the recently developed FSI-Levelset-CURVIB method of Calderer, Kang and Sotiropoulos (JCP 2014) to accurately predict turbine-wave interactions. The numerical approach is based on solving the Navier-Stokes equations coupled with the level set method, which is capable of carrying out LES of two-phase flows (air and water) with complex floating structures and waves. The investigated floating turbine is a 1:100 Froude scaled version of the 13.2 MW prototype designed by Sandia National Lab; it is installed on a cylindrical barge style platform which is restricted to move with two degrees of freedom, heave and pitch in the vertical plane defined by the direction of the propagating 2D waves. The computed turbine kinematics as well as the free surface elevation results are compared with the experimental data for different free decay tests and wave conditions representative of the Maine and the Pacific North West coasts. The comparison shows promising results indicating the validity of the model for simulating operational floating turbines. This work is supported by the US Department of Energy (DE-EE0005482), the University of Minnesota IREE program, and the Minnesota Supercomputing Institute.

  14. Modelling of PEM Fuel Cell Performance: Steady-State and Dynamic Experimental Validation

    Directory of Open Access Journals (Sweden)

    Idoia San Martín

    2014-02-01

    Full Text Available This paper reports on the modelling of a commercial 1.2 kW proton exchange membrane fuel cell (PEMFC, based on interrelated electrical and thermal models. The electrical model proposed is based on the integration of the thermodynamic and electrochemical phenomena taking place in the FC whilst the thermal model is established from the FC thermal energy balance. The combination of both models makes it possible to predict the FC voltage, based on the current demanded and the ambient temperature. Furthermore, an experimental characterization is conducted and the parameters for the models associated with the FC electrical and thermal performance are obtained. The models are implemented in Matlab Simulink and validated in a number of operating environments, for steady-state and dynamic modes alike. In turn, the FC models are validated in an actual microgrid operating environment, through the series connection of 4 PEMFC. The simulations of the models precisely and accurately reproduce the FC electrical and thermal performance.

  15. Phantom-based experimental validation of computational fluid dynamics simulations on cerebral aneurysms

    Energy Technology Data Exchange (ETDEWEB)

    Sun Qi; Groth, Alexandra; Bertram, Matthias; Waechter, Irina; Bruijns, Tom; Hermans, Roel; Aach, Til [Philips Research Europe, Weisshausstrasse 2, 52066 Aachen (Germany) and Institute of Imaging and Computer Vision, RWTH Aachen University, Sommerfeldstrasse 24, 52074 Aachen (Germany); Philips Research Europe, Weisshausstrasse 2, 52066 Aachen (Germany); Philips Healthcare, X-Ray Pre-Development, Veenpluis 4-6, 5684PC Best (Netherlands); Institute of Imaging and Computer Vision, RWTH Aachen University, Sommerfeldstrasse 24, 52074 Aachen (Germany)

    2010-09-15

    Purpose: Recently, image-based computational fluid dynamics (CFD) simulation has been applied to investigate the hemodynamics inside human cerebral aneurysms. The knowledge of the computed three-dimensional flow fields is used for clinical risk assessment and treatment decision making. However, the reliability of the application specific CFD results has not been thoroughly validated yet. Methods: In this work, by exploiting a phantom aneurysm model, the authors therefore aim to prove the reliability of the CFD results obtained from simulations with sufficiently accurate input boundary conditions. To confirm the correlation between the CFD results and the reality, virtual angiograms are generated by the simulation pipeline and are quantitatively compared to the experimentally acquired angiograms. In addition, a parametric study has been carried out to systematically investigate the influence of the input parameters associated with the current measuring techniques on the flow patterns. Results: Qualitative and quantitative evaluations demonstrate good agreement between the simulated and the real flow dynamics. Discrepancies of less than 15% are found for the relative root mean square errors of time intensity curve comparisons from each selected characteristic position. The investigated input parameters show different influences on the simulation results, indicating the desired accuracy in the measurements. Conclusions: This study provides a comprehensive validation method of CFD simulation for reproducing the real flow field in the cerebral aneurysm phantom under well controlled conditions. The reliability of the CFD is well confirmed. Through the parametric study, it is possible to assess the degree of validity of the associated CFD model based on the parameter values and their estimated accuracy range.

  16. Unfolding linac photon spectra and incident electron energies from experimental transmission data, with direct independent validation.

    Science.gov (United States)

    Ali, E S M; McEwen, M R; Rogers, D W O

    2012-11-01

    In a recent computational study, an improved physics-based approach was proposed for unfolding linac photon spectra and incident electron energies from transmission data. In this approach, energy differentiation is improved by simultaneously using transmission data for multiple attenuators and detectors, and the unfolding robustness is improved by using a four-parameter functional form to describe the photon spectrum. The purpose of the current study is to validate this approach experimentally, and to demonstrate its application on a typical clinical linac. The validation makes use of the recent transmission measurements performed on the Vickers research linac of National Research Council Canada. For this linac, the photon spectra were previously measured using a NaI detector, and the incident electron parameters are independently known. The transmission data are for eight beams in the range 10-30 MV using thick Be, Al and Pb bremsstrahlung targets. To demonstrate the approach on a typical clinical linac, new measurements are performed on an Elekta Precise linac for 6, 10 and 25 MV beams. The different experimental setups are modeled using EGSnrc, with the newly added photonuclear attenuation included. For the validation on the research linac, the 95% confidence bounds of the unfolded spectra fall within the noise of the NaI data. The unfolded spectra agree with the EGSnrc spectra (calculated using independently known electron parameters) with RMS energy fluence deviations of 4.5%. The accuracy of unfolding the incident electron energy is shown to be ∼3%. A transmission cutoff of only 10% is suitable for accurate unfolding, provided that the other components of the proposed approach are implemented. For the demonstration on a clinical linac, the unfolded incident electron energies and their 68% confidence bounds for the 6, 10 and 25 MV beams are 6.1 ± 0.1, 9.3 ± 0.1, and 19.3 ± 0.2 MeV, respectively. The unfolded spectra for the clinical linac agree with the

  17. A selection of experimental test cases for the validation of CFD codes, volume 1

    Science.gov (United States)

    1994-08-01

    This report presents the results of a study by Working Group 14 of the AGARD Fluid Dynamics Panel. This group was formed to establish an accessible, detailed experimental data base for the validation of Computational Fluid Dynamics (CFD) codes. The thirty nine test cases that are documented cover the subsonic, transonic, and supersonic flow regimes and five classes of geometries. Included in the five classes of geometries are: two dimensional airfoils; three dimensional wings, designed for predominantly attached flow conditions; slender bodies, typical of missile type configurations; delta wings, characterized by a conical type of vortex flow; and complex configurations, either in a geometrical sense or because of complicated flow interactions. The report is presented in two volumes. Volume 1 provides a review of the theoretical and experimental requirements, a general introduction and summary of the test cases, and recommendations for the future. Volume 2 contains detailed information on the test cases. The relevant data of all test cases has been compiled on floppy disks, which can be obtained through National Centers.

  18. Distributed parameter model and experimental validation of a compressive-mode energy harvester under harmonic excitations

    Energy Technology Data Exchange (ETDEWEB)

    Li, H.T. [Department of Engineering Mechanics, Northwestern Polytechnical University, Xian (China); Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario (Canada); Yang, Z.; Zu, J. [Department of Mechanical & Industrial Engineering, University of Toronto, Toronto, Ontario (Canada); Qin, W. Y., E-mail: qinweiyang67@gmail.com [Department of Engineering Mechanics, Northwestern Polytechnical University, Xian (China)

    2016-08-15

    This paper presents the modeling and parametric analysis of the recently proposed nonlinear compressive-mode energy harvester (HC-PEH) under harmonic excitation. Both theoretical and experimental investigations are performed in this study over a range of excitation frequencies. Specially, a distributed parameter electro-elastic model is analytically developed by means of the energy-based method and the extended Hamilton’s principle. An analytical formulation of bending and stretching forces are derived to gain insight on the source of nonlinearity. Furthermore, the analytical model is validated against with experimental data and a good agreement is achieved. Both numerical simulations and experiment illustrate that the harvester exhibits a hardening nonlinearity and hence a broad frequency bandwidth, multiple coexisting solutions and a large-amplitude voltage response. Using the derived model, a parametric study is carried out to examine the effect of various parameters on the harvester voltage response. It is also shown from parametric analysis that the harvester’s performance can be further improved by selecting the proper length of elastic beams, proof mass and reducing the mechanical damping.

  19. Design and experimental validation of a Bonner Sphere Spectrometer based on Dysprosium activation foils

    Energy Technology Data Exchange (ETDEWEB)

    Bedogni, R., E-mail: roberto.bedogni@lnf.infn.i [INFN - LNF (Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali di Frascati), Via E. Fermi n. 40, 00044 Frascati (Italy); Ferrari, P.; Gualdrini, G. [ENEA Radiation Protection Institute, via dei Colli n. 16, 40136, Bologna (Italy); Esposito, A. [INFN - LNF (Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali di Frascati), Via E. Fermi n. 40, 00044 Frascati (Italy)

    2010-12-15

    The increasing demand of rapid and reliable experimental techniques for the dosimetric characterization of high-intensity neutron fields, as those produced by radiotherapy and radioisotope installations, is the main reason for this study. In the past years INFN implemented a Bonner Sphere System, equipped with TLDs or gold activation foils, which was successfully employed for neutron spectra measurements around medical LINACs. The INFN-ENEA collaboration extended this methodology to Dysprosium activation foils. Taking advantage of the high activation cross section (2700 barn at 0.025 eV), the photon insensitivity and the reasonably short half live (2.334 h), the Dy-based BSS (Dy-BSS) is highly suited for operational measurements, where short irradiations and short measurement times are desirable. This work presents the response matrix of the Dy-BSS, calculated with MCNPX, and the results of its experimental validation, performed with reference neutron fields at the ENEA-Bologna labs. In addition, the newly developed Dy-BSS and the traditional gold foil-based BSS are compared, underlying the advantages of the new system.

  20. Oil presence in an evaporator: experimental validation of a refrigerant/oil mixture enthalpy calculation model

    Energy Technology Data Exchange (ETDEWEB)

    Youbi-Idrissi, M.; Bonjour, J.; Terrier, M.-F.; Meunier, F. [Laboratoire du Froid, Paris Cedex (France); Marvillet, C. [GRETh, CEA Grenoble (France)

    2004-05-01

    In this paper, the impact of the oil presence on the performance of a refrigerating machine is investigated both experimentally and numerically. To highlight the effect of oil, particularly on the evaporator behaviour, a theoretical model of enthalpy calculation for a refrigerant/oil mixture has been previously developed [Int J Refrigeration, 26(2003), 284]. In order to validate this model, tests were carried out on an industrial refrigerating machine working with R-407C. The lubricant is a polyol-ester oil whose solubility curves are given by the oil manufacturer. The oil circulating mass fraction is measured by a sampling technique and by an on-line density measurement method, whose advantages and drawbacks are presented. Both the model and the experiments show that the ratio of enthalpy change through the evaporator with to without the oil presence increases when the apparent superheat at the evaporator outlet increases. This is due to the presence of a non-evaporated amount of liquid refrigerant dissolved in the oil at this location, which is confirmed by visual observations. The numerical and experimental results are found to be in a good agreement as the maximum deviation is about 2.2%. (author)

  1. Numerical Simulation and Experimental Validation of Failure Caused by Vibration of a Fan

    Science.gov (United States)

    Zhou, Qiang; Han, Wu; Feng, Jianmei; Jia, Xiaohan; Peng, Xueyuan

    2017-08-01

    This paper presents the root cause analysis of an unexpected fracture occurred on the blades of a motor fan used in a natural gas reciprocating compressor unit. A finite element model was established to investigate the natural frequencies and modal shapes of the fan, and a modal test was performed to verify the numerical results. It was indicated that the numerical results agreed well with experimental data. The third order natural frequency was close to the six times excitation frequency, and the corresponding modal shape was the combination of bending and torsional vibration, which consequently contributed to low-order resonance and fracture failure of the fan. The torsional moment obtained by a torsional vibration analysis of the compressor shaft system was exerted on the numerical model of the fan to evaluate the dynamic stress response of the fan. The results showed that the stress concentration regions on the numerical model were consistent with the location of fractures on the fan. Based on the numerical simulation and experimental validation, some recommendations were given to improve the reliability of the motor fan.

  2. Experimental Validation of the Electrokinetic Theory and Development of Seismoelectric Interferometry by Cross-Correlation

    Directory of Open Access Journals (Sweden)

    F. C. Schoemaker

    2012-01-01

    Full Text Available We experimentally validate a relatively recent electrokinetic formulation of the streaming potential (SP coefficient as developed by Pride (1994. The start of our investigation focuses on the streaming potential coefficient, which gives rise to the coupling of mechanical and electromagnetic fields. It is found that the theoretical amplitude values of this dynamic SP coefficient are in good agreement with the normalized experimental results over a wide frequency range, assuming no frequency dependence of the bulk conductivity. By adopting the full set of electrokinetic equations, a full-waveform wave propagation model is formulated. We compare the model predictions, neglecting the interface response and modeling only the coseismic fields, with laboratory measurements of a seismic wave of frequency 500 kHz that generates electromagnetic signals. Agreement is observed between measurement and electrokinetic theory regarding the coseismic electric field. The governing equations are subsequently adopted to study the applicability of seismoelectric interferometry. It is shown that seismic sources at a single boundary location are sufficient to retrieve the 1D seismoelectric responses, both for the coseismic and interface components, in a layered model.

  3. Experimental Validation of a Fast Forward Model for Guided Wave Tomography of Pipe Elbows.

    Science.gov (United States)

    Brath, Alex J; Simonetti, Francesco; Nagy, Peter B; Instanes, Geir

    2017-05-01

    Ultrasonic guided wave tomography (GWT) methods for the detection of corrosion and erosion damage in straight pipe sections are now well advanced. However, successful application of GWT to pipe bends has not yet been demonstrated due to the computational burden associated with the complex forward model required to simulate guided wave propagation through the bend. In a previous paper [Brath et al., IEEE Trans. Ultrason., Ferroelectr., Freq. Control, vol. 61, pp. 815-829, 2014], we have shown that the speed of the forward model can be increased by replacing the 3-D pipe bend with a 2-D rectangular domain in which guided wave propagation is formulated based on an artificially inhomogeneous and elliptically anisotropic (INELAN) acoustic model. This paper provides further experimental validation of the INLEAN model by studying the traveltime shifts caused by the introduction of shallow defects on the elbow of a pipe bend. Comparison between experiments and simulations confirms that a defect can be modeled as a phase velocity perturbation to the INLEAN velocity field with accuracy that is within the experimental error of the measurements. In addition, it is found that the sensitivity of traveltime measurements to the presence of damage decreases as the damage position moves from the interior side of the bend (intrados) to the exterior one (extrados). This effect is due to the nonuniform ray coverage obtainable when transmitting the guided wave signals with one ring array of sources on one side of the elbow and receiving with a second array on the other side.

  4. Experimental Validation of Numerical Simulations for an Acoustic Liner in Grazing Flow

    Science.gov (United States)

    Tam, Christopher K. W.; Pastouchenko, Nikolai N.; Jones, Michael G.; Watson, Willie R.

    2013-01-01

    A coordinated experimental and numerical simulation effort is carried out to improve our understanding of the physics of acoustic liners in a grazing flow as well our computational aeroacoustics (CAA) method prediction capability. A numerical simulation code based on advanced CAA methods is developed. In a parallel effort, experiments are performed using the Grazing Flow Impedance Tube at the NASA Langley Research Center. In the experiment, a liner is installed in the upper wall of a rectangular flow duct with a 2 inch by 2.5 inch cross section. Spatial distribution of sound pressure levels and relative phases are measured on the wall opposite the liner in the presence of a Mach 0.3 grazing flow. The computer code is validated by comparing computed results with experimental measurements. Good agreements are found. The numerical simulation code is then used to investigate the physical properties of the acoustic liner. It is shown that an acoustic liner can produce self-noise in the presence of a grazing flow and that a feedback acoustic resonance mechanism is responsible for the generation of this liner self-noise. In addition, the same mechanism also creates additional liner drag. An estimate, based on numerical simulation data, indicates that for a resonant liner with a 10% open area ratio, the drag increase would be about 4% of the turbulent boundary layer drag over a flat wall.

  5. Experimental validation of sound field control with a circular double-layer array of loudspeakers.

    Science.gov (United States)

    Chang, Ji-Ho; Jacobsen, Finn

    2013-04-01

    This paper is concerned with experimental validation of a recently proposed method of controlling sound fields with a circular double-layer array of loudspeakers [Chang and Jacobsen, J. Acoust. Soc. Am. 131(6), 4518-4525 (2012)]. The double-layer of loudspeakers is realized with 20 pairs of closed-box loudspeakers mounted back-to-back. Source strengths are obtained with several solution methods by modeling loudspeakers as a weighted combination of monopoles and dipoles. Sound pressure levels of the controlled sound fields are measured inside and outside the array in an anechoic room, and performance indices are calculated. The experimental results show that a method of combining pure contrast maximization with a pressure matching technique provides only a small error in the listening zone between the desired and the reproduced fields, and at the same time reduces the sound level in the quiet zone as expected in the simulation studies well above the spatial Nyquist frequency except at a few frequencies. It is also shown that errors in the positions of the loudspeakers can be critical to the results at frequencies where the distance between the inner and the outer array is close to half a wavelength.

  6. Comprehensive Analysis and Experimental Validation of an Improved Mathematical Modeling of Photovoltaic Array

    Directory of Open Access Journals (Sweden)

    Satarupa Bal

    2015-01-01

    Full Text Available This paper proposes a simple, accurate, and easy to model approach for the simulation of photovoltaic (PV array and also provides a comparative analysis of the same with two other widely used models. It is highly imperative that the maximum power point (MPP is achieved effectively and thus a simple and robust mathematical model is necessary that poses less mathematical complexity as well as low data storage requirement, in which the maximum power point tracking (MPPT algorithm can be realized in an effective way. Further, the resemblance of the P-V and I-V curves as obtained on the basis of experimental data should also be taken into account for theoretical validation. In addition, the study incorporates the root mean square deviation (RMSD from the experimental data, the fill factor (FF, the efficiency of the model, and the time required for simulation. Two models have been used to investigate the I-V and P-V characteristics. Perturb and Observe method has been adopted for MPPT. The MPP tracking is realized using field programmable gate array (FPGA to prove the effectiveness of the proposed approach. All the systems are modeled and simulated in MATLAB/Simulink environment.

  7. Experimental validation of convection-diffusion discretisation scheme employed for computational modelling of biological mass transport

    Directory of Open Access Journals (Sweden)

    Ku David N

    2010-07-01

    Full Text Available Abstract Background The finite volume solver Fluent (Lebanon, NH, USA is a computational fluid dynamics software employed to analyse biological mass-transport in the vasculature. A principal consideration for computational modelling of blood-side mass-transport is convection-diffusion discretisation scheme selection. Due to numerous discretisation schemes available when developing a mass-transport numerical model, the results obtained should either be validated against benchmark theoretical solutions or experimentally obtained results. Methods An idealised aneurysm model was selected for the experimental and computational mass-transport analysis of species concentration due to its well-defined recirculation region within the aneurysmal sac, allowing species concentration to vary slowly with time. The experimental results were obtained from fluid samples extracted from a glass aneurysm model, using the direct spectrophometric concentration measurement technique. The computational analysis was conducted using the four convection-diffusion discretisation schemes available to the Fluent user, including the First-Order Upwind, the Power Law, the Second-Order Upwind and the Quadratic Upstream Interpolation for Convective Kinetics (QUICK schemes. The fluid has a diffusivity of 3.125 × 10-10 m2/s in water, resulting in a Peclet number of 2,560,000, indicating strongly convection-dominated flow. Results The discretisation scheme applied to the solution of the convection-diffusion equation, for blood-side mass-transport within the vasculature, has a significant influence on the resultant species concentration field. The First-Order Upwind and the Power Law schemes produce similar results. The Second-Order Upwind and QUICK schemes also correlate well but differ considerably from the concentration contour plots of the First-Order Upwind and Power Law schemes. The computational results were then compared to the experimental findings. An average error of 140

  8. Experimental Definition and Validation of Protein Coding Transcripts in Chlamydomonas reinhardtii

    Energy Technology Data Exchange (ETDEWEB)

    Kourosh Salehi-Ashtiani; Jason A. Papin

    2012-01-13

    Algal fuel sources promise unsurpassed yields in a carbon neutral manner that minimizes resource competition between agriculture and fuel crops. Many challenges must be addressed before algal biofuels can be accepted as a component of the fossil fuel replacement strategy. One significant challenge is that the cost of algal fuel production must become competitive with existing fuel alternatives. Algal biofuel production presents the opportunity to fine-tune microbial metabolic machinery for an optimal blend of biomass constituents and desired fuel molecules. Genome-scale model-driven algal metabolic design promises to facilitate both goals by directing the utilization of metabolites in the complex, interconnected metabolic networks to optimize production of the compounds of interest. Using Chlamydomonas reinhardtii as a model, we developed a systems-level methodology bridging metabolic network reconstruction with annotation and experimental verification of enzyme encoding open reading frames. We reconstructed a genome-scale metabolic network for this alga and devised a novel light-modeling approach that enables quantitative growth prediction for a given light source, resolving wavelength and photon flux. We experimentally verified transcripts accounted for in the network and physiologically validated model function through simulation and generation of new experimental growth data, providing high confidence in network contents and predictive applications. The network offers insight into algal metabolism and potential for genetic engineering and efficient light source design, a pioneering resource for studying light-driven metabolism and quantitative systems biology. Our approach to generate a predictive metabolic model integrated with cloned open reading frames, provides a cost-effective platform to generate metabolic engineering resources. While the generated resources are specific to algal systems, the approach that we have developed is not specific to algae and

  9. Combined Heat Transfer in High-Porosity High-Temperature Fibrous Insulations: Theory and Experimental Validation

    Science.gov (United States)

    Daryabeigi, Kamran; Cunnington, George R.; Miller, Steve D.; Knutson, Jeffry R.

    2010-01-01

    Combined radiation and conduction heat transfer through various high-temperature, high-porosity, unbonded (loose) fibrous insulations was modeled based on first principles. The diffusion approximation was used for modeling the radiation component of heat transfer in the optically thick insulations. The relevant parameters needed for the heat transfer model were derived from experimental data. Semi-empirical formulations were used to model the solid conduction contribution of heat transfer in fibrous insulations with the relevant parameters inferred from thermal conductivity measurements at cryogenic temperatures in a vacuum. The specific extinction coefficient for radiation heat transfer was obtained from high-temperature steady-state thermal measurements with large temperature gradients maintained across the sample thickness in a vacuum. Standard gas conduction modeling was used in the heat transfer formulation. This heat transfer modeling methodology was applied to silica, two types of alumina, and a zirconia-based fibrous insulation, and to a variation of opacified fibrous insulation (OFI). OFI is a class of insulations manufactured by embedding efficient ceramic opacifiers in various unbonded fibrous insulations to significantly attenuate the radiation component of heat transfer. The heat transfer modeling methodology was validated by comparison with more rigorous analytical solutions and with standard thermal conductivity measurements. The validated heat transfer model is applicable to various densities of these high-porosity insulations as long as the fiber properties are the same (index of refraction, size distribution, orientation, and length). Furthermore, the heat transfer data for these insulations can be obtained at any static pressure in any working gas environment without the need to perform tests in various gases at various pressures.

  10. Mechanical behavior of a sandwich with corrugated GRP core: numerical modeling and experimental validation

    Directory of Open Access Journals (Sweden)

    D. Tumino

    2014-10-01

    Full Text Available In this work the mechanical behaviour of a core reinforced composite sandwich structure is studied. The sandwich employs a Glass Reinforced Polymer (GRP orthotropic material for both the two external skins and the inner core web. In particular, the core is designed in order to cooperate with the GRP skins in membrane and flexural properties by means of the addition of a corrugated laminate into the foam core. An analytical model has been developed to replace a unit cell of this structure with an orthotropic equivalent thick plate that reproduces the in plane and out of plane behaviour of the original geometry. Different validation procedures have been implemented to verify the quality of the proposed method. At first a comparison has been performed between the analytical model and the original unit cell modelled with a Finite Element mesh. Elementary loading conditions are reproduced and results are compared. Once the reliability of the analytical model was assessed, this homogenised model was implemented within the formulation of a shell finite element. The goal of this step is to simplify the FE analysis of complex structures made of corrugated core sandwiches; in fact, by using the homogenised element, the global response of a real structure can be investigated only with the discretization of its mid-surface. Advantages are mainly in terms of time to solution saving and CAD modelling simplification. Last step is then the comparison between this FE model and experiments made on sandwich beams and panels whose skins and corrugated cores are made of orthotropic cross-ply GRP laminates. Good agreement between experimental and numerical results confirms the validity of the proposed model.

  11. Math primer for engineers

    CERN Document Server

    Cryer, CW

    2014-01-01

    Mathematics and engineering are inevitably interrelated, and this interaction will steadily increase as the use of mathematical modelling grows. Although mathematicians and engineers often misunderstand one another, their basic approach is quite similar, as is the historical development of their respective disciplines. The purpose of this Math Primer is to provide a brief introduction to those parts of mathematics which are, or could be, useful in engineering, especially bioengineering. The aim is to summarize the ideas covered in each subject area without going into exhaustive detail. Formula

  12. Primer on Health Surveys

    Directory of Open Access Journals (Sweden)

    David L Nordstrom

    2012-06-01

    Full Text Available The aim of this paper is to introduce novice researchers to surveys as a method of data collection. It starts with the definition of a survey, its major purposes and types as well as changes in the goals surveys have helped to achieve over time. Advantages and disadvantages of surveys over population censuses and medical examinations are discussed. Approaches to questionnaire construction are introduced along with properties that questionnaires are evaluated for. Modes of administration, sample size issues, and data analysis approaches are also introduced. The primer is illustrated with examples of surveys conducted in different countries with various public health purposes.

  13. Modeling and experimental validation of trabecular bone damage, softening and densification under large compressive strains.

    Science.gov (United States)

    Hosseini, Hadi S; Pahr, Dieter H; Zysset, Philippe K

    2012-11-01

    Vertebral fractures represent a major health problem and involve the progressive collapse of trabecular bone over large compressive strains. This collapse is driven by local failure and interaction of the trabecular rod and plate elements, which translates into stress softening and densification at the material level. Current constitutive models for trabecular bone are essentially limited to infinitesimal strains. Accordingly, the aim of this work was to extend our current phenomenological model of trabecular bone (Garcia et al., 2009) for the simulation of large compressive strains by including post-yield softening and densification. A constitutive model of trabecular bone based on both volume fraction and trabecular orientation was formulated in a proper theoretical framework, implemented in commercial FE software and validated with human vertebral sections subjected to large compressive strains. As it is for infinitesimal strains, the evolution of plastic strains and damage is described by local internal variables. An isotropic softening rule was controlled by the cumulated plastic strain and a non-linear elastic spring was added to account for densification of the porous material in moderate-to-large compressive strains beyond a given threshold. To avoid convergence problems occurring as a result of softening, a consistent visco-plastic regularization approach was adopted. The experimental results for 37 vertebral sections from previous work (Dall'Ara et al., 2010) were used to validate the constitutive model for compressive loading up to 45% of the average axial deformation. This validation study showed that the model provides both qualitative predictions of damage localization on the cortex and quantitative predictions of dissipated energy (ρ(C)=0.912) of vertebral body behavior under large compressive strains. Since the evolution of the internal variables was considered in local manner, a mesh sensitivity analysis of the finite element model was conducted

  14. Experimental Testing and Model Validation of a Decoupled-Phase On-Load Tap Changer Transformer in an Active Network

    DEFF Research Database (Denmark)

    Zecchino, Antonio; Hu, Junjie; Coppo, Massimiliano

    2016-01-01

    this problem, distribution transformers with on-load tapping capability are under development. This paper presents model and experimental validation of a 35 kVA three-phase power distribution transformer with independent on-load tap changer control capability on each phase. With the purpose of investigating...... to reproduce the main feature of an unbalanced grid. The experimental activities are recreated in by carrying out dynamics simulation studies, aiming at validating the implemented models of both the transformer as well as the other grid components. Phase-neutral voltages’ deviations are limited, proving...

  15. Experimental validation of a sub-surface model of solar power for distributed marine sensor systems

    Science.gov (United States)

    Hahn, Gregory G.; Cantin, Heather P.; Shafer, Michael W.

    2016-04-01

    The capabilities of distributed sensor systems such as marine wildlife telemetry tags could be significantly enhanced through the integration of photovoltaic modules. Photovoltaic cells could be used to supplement the primary batteries for wildlife telemetry tags to allow for extended tag deployments, wherein larger amounts of data could be collected and transmitted in near real time. In this article, we present experimental results used to validate and improve key aspects of our original model for sub-surface solar power. We discuss the test methods and results, comparing analytic predictions to experimental results. In a previous work, we introduced a model for sub-surface solar power that used analytic models and empirical data to predict the solar irradiance available for harvest at any depth under the ocean's surface over the course of a year. This model presented underwater photovoltaic transduction as a viable means of supplementing energy for marine wildlife telemetry tags. The additional data provided by improvements in daily energy budgets would enhance the temporal and spatial comprehension of the host's activities and/or environments. Photovoltaic transduction is one method that has not been widely deployed in the sub-surface marine environments despite widespread use on terrestrial and avian species wildlife tag systems. Until now, the use of photovoltaic cells for underwater energy harvesting has generally been disregarded as a viable energy source in this arena. In addition to marine telemetry systems, photovoltaic energy harvesting systems could also serve as a means of energy supply for autonomous underwater vehicles (AUVs), as well as submersible buoys for oceanographic data collection.

  16. An Experimentally Validated Numerical Modeling Technique for Perforated Plate Heat Exchangers.

    Science.gov (United States)

    White, M J; Nellis, G F; Kelin, S A; Zhu, W; Gianchandani, Y

    2010-11-01

    Cryogenic and high-temperature systems often require compact heat exchangers with a high resistance to axial conduction in order to control the heat transfer induced by axial temperature differences. One attractive design for such applications is a perforated plate heat exchanger that utilizes high conductivity perforated plates to provide the stream-to-stream heat transfer and low conductivity spacers to prevent axial conduction between the perforated plates. This paper presents a numerical model of a perforated plate heat exchanger that accounts for axial conduction, external parasitic heat loads, variable fluid and material properties, and conduction to and from the ends of the heat exchanger. The numerical model is validated by experimentally testing several perforated plate heat exchangers that are fabricated using microelectromechanical systems based manufacturing methods. This type of heat exchanger was investigated for potential use in a cryosurgical probe. One of these heat exchangers included perforated plates with integrated platinum resistance thermometers. These plates provided in situ measurements of the internal temperature distribution in addition to the temperature, pressure, and flow rate measured at the inlet and exit ports of the device. The platinum wires were deposited between the fluid passages on the perforated plate and are used to measure the temperature at the interface between the wall material and the flowing fluid. The experimental testing demonstrates the ability of the numerical model to accurately predict both the overall performance and the internal temperature distribution of perforated plate heat exchangers over a range of geometry and operating conditions. The parameters that were varied include the axial length, temperature range, mass flow rate, and working fluid.

  17. An Experimentally Validated Numerical Modeling Technique for Perforated Plate Heat Exchangers

    Science.gov (United States)

    Nellis, G. F.; Kelin, S. A.; Zhu, W.; Gianchandani, Y.

    2010-01-01

    Cryogenic and high-temperature systems often require compact heat exchangers with a high resistance to axial conduction in order to control the heat transfer induced by axial temperature differences. One attractive design for such applications is a perforated plate heat exchanger that utilizes high conductivity perforated plates to provide the stream-to-stream heat transfer and low conductivity spacers to prevent axial conduction between the perforated plates. This paper presents a numerical model of a perforated plate heat exchanger that accounts for axial conduction, external parasitic heat loads, variable fluid and material properties, and conduction to and from the ends of the heat exchanger. The numerical model is validated by experimentally testing several perforated plate heat exchangers that are fabricated using microelectromechanical systems based manufacturing methods. This type of heat exchanger was investigated for potential use in a cryosurgical probe. One of these heat exchangers included perforated plates with integrated platinum resistance thermometers. These plates provided in situ measurements of the internal temperature distribution in addition to the temperature, pressure, and flow rate measured at the inlet and exit ports of the device. The platinum wires were deposited between the fluid passages on the perforated plate and are used to measure the temperature at the interface between the wall material and the flowing fluid. The experimental testing demonstrates the ability of the numerical model to accurately predict both the overall performance and the internal temperature distribution of perforated plate heat exchangers over a range of geometry and operating conditions. The parameters that were varied include the axial length, temperature range, mass flow rate, and working fluid. PMID:20976021

  18. Development and experimental validation of a thermoelectric test bench for laboratory lessons

    Directory of Open Access Journals (Sweden)

    Antonio Rodríguez

    2013-12-01

    Full Text Available The refrigeration process reduces the temperature of a space or a given volume while the power generation process employs a source of thermal energy to generate electrical power. Because of the importance of these two processes, training of engineers in this area is of great interest. In engineering courses it is normally studied the vapor compression and absorption refrigeration, and power generation systems such as gas turbine and steam turbine. Another type of cooling and generation less studied within the engineering curriculum, having a great interest, it is cooling and thermal generation based on Peltier and Seebeck effects. The theoretical concepts are useful, but students have difficulties understanding the physical meaning of their possible applications. Providing students with tools to test and apply the theory in real applications, will lead to a better understanding of the subject. Engineers must have strong theoretical, computational and also experimental skills. A prototype test bench has been built and experimentally validated to perform practical lessons of thermoelectric generation and refrigeration. Using this prototype students learn the most effective way of cooling systems and thermal power generation as well as basic concepts associated with thermoelectricity. It has been proven that students learn the process of data acquisition, and the technology used in thermoelectric devices. These practical lessons are implemented for a 60 people group of students in the development of subject of Thermodynamic including in the Degree in Engineering in Industrial Technologies of Public University of Navarra. Normal 0 21 false false false ES X-NONE X-NONE Normal 0 21 false false false ES X-NONE X-NONE CFD simulation of a burner for syngas characterization and experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Fantozzi, Francesco; Desideri, Umberto [University of Perugia (Italy). Dept. of Industrial Engineering], Emails: fanto@unipg.it, umberto.desideri@unipg.it; D' Amico, Michele [University of Perugia (Italy). Dept. of Energetic Engineering], E-mail: damico@crbnet.it

    2009-07-01

    Biomass and waste are distributed and renewable energy sources that may contribute effectively to sustainability if used on a small and micro scale. This requires the transformation through efficient technologies (gasification, pyrolysis and anaerobic digestion) into a suitable gaseous fuel to use in small internal combustion engines and gas turbines. The characterization of biomass derived syngas during combustion is therefore a key issue to improve the performance of small scale integrated plants because synthesis gas show significant differences with respect to Natural Gas (mixture of gases, low calorific value, hydrogen content, tar and particulate content) that may turn into ignition problems, combustion instabilities, difficulties in emission control and fouling. To this aim a burner for syngas combustion and LHV measurement through mass and energy balance was realized and connected to the rotary-kiln laboratory scale pyrolyzer at the Department of Industrial Engineering of the University of Perugia. A computational fluid dynamics (CFD) simulation of the burner was carried out considering the combustion of propane to investigate temperature and pressure distribution, heat transmission and distribution of the combustion products and by products. The simulation was carried out using the CFD program Star-CD. Before the simulation a geometrical model of the burner was built and the volume of model was subdivided in cells. A sensibility analysis of cells was carried out to estimate the approximation degree of the model. Experimental data about combustion emission were carried out with the propane combustion in the burner, the comparison between numerical results and experimental data was studied to validate the simulation for future works involved with the combustion of treated or raw (syngas with tar) syngas obtained from pyrolysis process. (author)

  19. On the selection of shape and orientation of a greenhouse. Thermal modeling and experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Sethi, V.P. [Department of Mechanical Engineering, Punjab Agricultural University, Ludhiana 141 004, Punjab (India)

    2009-01-15

    In this study, five most commonly used single span shapes of greenhouses viz. even-span, uneven-span, vinery, modified arch and quonset type have been selected for comparison. The length, width and height (at the center) are kept same for all the selected shapes. A mathematical model for computing transmitted total solar radiation (beam, diffused and ground reflected) at each hour, for each month and at any latitude for the selected geometry greenhouses (through each wall, inclined surfaces and roofs) is developed for both east-west and north-south orientation. Computed transmitted solar radiation is then introduced in a transient thermal model developed to compute hourly inside air temperature for each shape and orientation. Experimental validation of both the models is carried out for the measured total solar radiation and inside air temperature for an east-west orientation, even-span greenhouse (for a typical day in summer) at Ludhiana (31 N and 77 E) Punjab, India. During the experimentation, capsicum crop is grown inside the greenhouse. The predicted and measured values are in close agreement. Results show that uneven-span shape greenhouse receives the maximum and quonset shape receives the minimum solar radiation during each month of the year at all latitudes. East-west orientation is the best suited for year round greenhouse applications at all latitudes as this orientation receives greater total radiation in winter and less in summer except near the equator. Results also show that inside air temperature rise depends upon the shape of the greenhouse and this variation from uneven-span shape to quonset shape is 4.6 C (maximum) and 3.5 C (daily average) at 31 N latitude. (author)

  1. El primer virreinato americano

    Directory of Open Access Journals (Sweden)

    Cassá, Roberto

    2006-12-01

    Full Text Available This article explores the government of viceroy Christopher Columbus in the American territories. We return to the first Spanish settlement in Santo Domingo and the contradictions inherent to this expansionist proyect. The contradictions were part of the logic of the absolutist state and Columbus’ reaction against the controls imposed by the monarchs. Secondly, we look into the dificulties that the Admiral encountered to develop a mercantilist model. In this context, we examine the rationale behind the first government of the Indies and the features that defined the new West Indian society.

    El artículo trata sobre el gobierno de Cristóbal Colón en tierras americanas. Retomamos el tema del primer emplazamiento español en Santo Domingo y las contradicciones que tuvo aquel proyecto debido a la lógica del estado absolutista, a la ambición desmedida del descubridor y a su reacción ante los controles que desde un principio impusieron los monarcas. En un segundo momento analizamos las dificultades que encontró el Almirante para desarrollar un modelo mercantilista acorde a sus ideas y a los acuerdos a que llegó con la Corona. En ese contexto analizamos la lógica del primer gobierno colombinista en las Indias y los rasgos que definieron la nueva sociedad antillana.

  2. Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers.

    Science.gov (United States)

    Sprague, Brienne; Shi, Qian; Kim, Marlene T; Zhang, Liying; Sedykh, Alexander; Ichiishi, Eiichiro; Tokuda, Harukuni; Lee, Kuo-Hsiung; Zhu, Hao

    2014-06-01

    Compared to the current knowledge on cancer chemotherapeutic agents, only limited information is available on the ability of organic compounds, such as drugs and/or natural products, to prevent or delay the onset of cancer. In order to evaluate chemical chemopreventive potentials and design novel chemopreventive agents with low to no toxicity, we developed predictive computational models for chemopreventive agents in this study. First, we curated a database containing over 400 organic compounds with known chemoprevention activities. Based on this database, various random forest and support vector machine binary classifiers were developed. All of the resulting models were validated by cross validation procedures. Then, the validated models were applied to virtually screen a chemical library containing around 23,000 natural products and derivatives. We selected a list of 148 novel chemopreventive compounds based on the consensus prediction of all validated models. We further analyzed the predicted active compounds by their ease of organic synthesis. Finally, 18 compounds were synthesized and experimentally validated for their chemopreventive activity. The experimental validation results paralleled the cross validation results, demonstrating the utility of the developed models. The predictive models developed in this study can be applied to virtually screen other chemical libraries to identify novel lead compounds for the chemoprevention of cancers.

  3. Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers

    Science.gov (United States)

    Sprague, Brienne; Shi, Qian; Kim, Marlene T.; Zhang, Liying; Sedykh, Alexander; Ichiishi, Eiichiro; Tokuda, Harukuni; Lee, Kuo-Hsiung; Zhu, Hao

    2014-06-01

    Compared to the current knowledge on cancer chemotherapeutic agents, only limited information is available on the ability of organic compounds, such as drugs and/or natural products, to prevent or delay the onset of cancer. In order to evaluate chemical chemopreventive potentials and design novel chemopreventive agents with low to no toxicity, we developed predictive computational models for chemopreventive agents in this study. First, we curated a database containing over 400 organic compounds with known chemoprevention activities. Based on this database, various random forest and support vector machine binary classifiers were developed. All of the resulting models were validated by cross validation procedures. Then, the validated models were applied to virtually screen a chemical library containing around 23,000 natural products and derivatives. We selected a list of 148 novel chemopreventive compounds based on the consensus prediction of all validated models. We further analyzed the predicted active compounds by their ease of organic synthesis. Finally, 18 compounds were synthesized and experimentally validated for their chemopreventive activity. The experimental validation results paralleled the cross validation results, demonstrating the utility of the developed models. The predictive models developed in this study can be applied to virtually screen other chemical libraries to identify novel lead compounds for the chemoprevention of cancers.

  4. Optimal Control of Diesel Engines: Numerical Methods, Applications, and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Jonas Asprion

    2014-01-01

    become complex systems. The exploitation of any leftover potential during transient operation is crucial. However, even an experienced calibration engineer cannot conceive all the dynamic cross couplings between the many actuators. Therefore, a highly iterative procedure is required to obtain a single engine calibration, which in turn causes a high demand for test-bench time. Physics-based mathematical models and a dynamic optimisation are the tools to alleviate this dilemma. This paper presents the methods required to implement such an approach. The optimisation-oriented modelling of diesel engines is summarised, and the numerical methods required to solve the corresponding large-scale optimal control problems are presented. The resulting optimal control input trajectories over long driving profiles are shown to provide enough information to allow conclusions to be drawn for causal control strategies. Ways of utilising this data are illustrated, which indicate that a fully automated dynamic calibration of the engine control unit is conceivable. An experimental validation demonstrates the meaningfulness of these results. The measurement results show that the optimisation predicts the reduction of the fuel consumption and the cumulative pollutant emissions with a relative error of around 10% on highly transient driving cycles.

  5. Design and Experimental Validation for Direct-Drive Fault-Tolerant Permanent-Magnet Vernier Machines

    Directory of Open Access Journals (Sweden)

    Guohai Liu

    2014-01-01

    Full Text Available A fault-tolerant permanent-magnet vernier (FT-PMV machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs. This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM, the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis.

  6. Models of TCP in high-BDP environments and their experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Vardoyan, G. [University of Massachusetts; Rao, Nageswara S [ORNL; Towlsey, D. [University of Massachusetts

    2016-01-01

    In recent years, the computer networking community has seen a steady growth in bandwidth-delay products (BDPs). Several TCP variants were created to combat the shortcomings of legacy TCP when it comes to operation in high-BDP environments. These variants, among which are CUBIC, STCP, and H-TCP, have been extensively studied in some empirical contexts, and some analytical models exist for CUBIC and STCP. However, since these studies have been conducted, BDPs have risen even more, and new bulk data transfer tools have emerged that utilize multiple parallel TCP streams. In view of these new developments, it is imperative to revisit the question: Which congestion control algorithms are best adapted to current networking environments? In order to help resolve this question, we contribute the following: (i) using first principles, we develop a general throughput-prediction framework that takes into account buffer sizes and maximum window constraints; (ii) we validate the models using measurements and achieve low prediction errors; (iii) we note differences in TCP dynamics between two experimental configurations and find one of them to be significantly more deterministic than the other; we also find that CUBIC and H-TCP outperform STCP, especially when multiple streams are used; and (iv) we present preliminary results for modelling multiple TCP streams for CUBIC and STCP.

  7. Experimental validation of crystalline silicon solar cells recycling by thermal and chemical methods

    Energy Technology Data Exchange (ETDEWEB)

    Klugmann-Radziemska, Ewa; Ostrowski, Piotr [Gdansk University of Technology, Chemical Faculty, Narutowicza 11/12, PL 80-233 Gdansk (Poland); Drabczyk, Kazimierz; Panek, Piotr [Polish Academy of Sciences, Institute of Metallurgy and Materials Science (Poland); Szkodo, Marek [Gdansk University of Technology, Faculty of Mechanical Engineering (Poland)

    2010-12-15

    In recent years, photovoltaic power generation systems have been gaining unprecedented attention as an environmentally beneficial method for solving the energy problem. From the economic point of view pure silicon, which can be recovered from spent cells, is the most important material owing to its cost and limited supply. The article presents a chemical method for recycling spent or damaged modules and cells, and the results of its experimental validation. The recycling of PV cells consists of two main steps: the separation of cells and their refinement. Cells are first separated thermally or chemically; the separated cells are then refined. During this process the antireflection, metal coating and p-n junction layers are removed in order to recover the silicon base, ready for its next use. This refinement step was performed using an optimised chemical method. Silicon wafers were examined with an environmental scanning electron microscope (ESEM) coupled to an EDX spectrometer. The silicon wafers were used for producing new silicon solar cells, which were then examined and characterized with internal spectral response and current-voltage characteristics. The new cells, despite the fact that they have no SiN{sub x} antireflective coating, have a very good efficiency of 13-15%. (author)

  8. Design of passive directional acoustic devices using Topology Optimization - from method to experimental validation.

    Science.gov (United States)

    Christiansen, Rasmus E; Fernandez-Grande, Efren

    2016-11-01

    The paper presents a topology optimization based method for designing acoustic focusing devices, capable of tailoring the sound emission pattern of one or several sources, across a chosen frequency band. The method is demonstrated numerically considering devices optimized for directional sound emission in two dimensions and is experimentally validated using three dimensional prints of the optimized designs. The emitted fields exhibit a level difference of at least 15 dB on axis relative to the off-axis directions, over frequency bands of approximately an octave. It is demonstrated to be possible to design focusing devices of dimensions comparable to the acoustic wavelength, a frequency range which is typically problematic, as well as devices operating at higher frequencies. The classical parabolic reflector is used as a benchmark. The devices designed using the proposed method are shown to outperform the latter in terms of directivity and maximum side-lobe level over nearly an octave band. A set of frequencies are considered simultaneously in the design formulation and performance robustness toward uniform spatial production errors in the designed devices is assured by including perturbations of the geometry in the design formulation.

  9. Design and Experimental Validation of Small Activating RNAs Targeting an Exogenous Promoter in Human Cells.

    Science.gov (United States)

    Harris, Edouard A; Buzina, Alla; Moffat, Jason; McMillen, David R

    2017-04-21

    It is increasingly practical to co-opt many native cellular components into use as elements of synthetic biological systems. We present the design and experimental investigation of the first exogenous genetic construct to be successfully targeted by RNA activation, a phenomenon whereby small double-stranded RNAs increase gene expression from sequence-similar promoters by a mechanism thought to be related to that of RNA interference. Our selection of activating RNA candidates was informed by a custom-written computer program designed to choose target sites in the promoter of interest according to a set of empirical optimality criteria drawn from prior research. Activating RNA candidates were assessed for activity against two exogenously derived target promoters, with successful candidates being subjected to further rounds of validation as a precaution against potential off-target effects. A genetic platform was assembled that allowed activating RNA candidates to be simultaneously screened both for positive activity on the target reporter gene and for possible nonspecific effects on cell metabolism. Several candidate sequences were tested to appraise the utility of this platform, with the most successful achieving a moderate activation level with minimal off-target effects.

  10. Calculation improvement of no-load stray losses in induction motors with experimental validation

    Directory of Open Access Journals (Sweden)

    Kostić Miloje M.

    2015-01-01

    Full Text Available On the basis of the known fact that all air gap main flux density variations are enclosed by permeance slot harmonics, only one component of stray losses in rotor (stator iron is considered in the new classification, instead of 2 components: rotor (stator pulsation iron losses, and rotor (stator surface iron losses. No-load rotor cage (high-frequency stray losses are usually calculated. No-load stray losses are caused by the existence of space harmonics: the air-gap slot permeance harmonics and the harmonics produced by no-load MMF harmonics. The second result is the proof that the corresponding components of stray losses can be calculated separately for the mentioned kind of harmonics. Determination of the depth of flux penetration and calculations of high frequency iron losses are improved. On the basis of experimental validation, it is proved that the new classification of no-load stray losses and the proposed method for the calculation of the total value is sufficiently accurate.

  11. GLASS: a comprehensive database for experimentally validated GPCR-ligand associations.

    Science.gov (United States)

    Chan, Wallace K B; Zhang, Hongjiu; Yang, Jianyi; Brender, Jeffrey R; Hur, Junguk; Özgür, Arzucan; Zhang, Yang

    2015-09-15

    G protein-coupled receptors (GPCRs) are probably the most attractive drug target membrane proteins, which constitute nearly half of drug targets in the contemporary drug discovery industry. While the majority of drug discovery studies employ existing GPCR and ligand interactions to identify new compounds, there remains a shortage of specific databases with precisely annotated GPCR-ligand associations. We have developed a new database, GLASS, which aims to provide a comprehensive, manually curated resource for experimentally validated GPCR-ligand associations. A new text-mining algorithm was proposed to collect GPCR-ligand interactions from the biomedical literature, which is then crosschecked with five primary pharmacological datasets, to enhance the coverage and accuracy of GPCR-ligand association data identifications. A special architecture has been designed to allow users for making homologous ligand search with flexible bioactivity parameters. The current database contains ∼500 000 unique entries, of which the vast majority stems from ligand associations with rhodopsin- and secretin-like receptors. The GLASS database should find its most useful application in various in silico GPCR screening and functional annotation studies. The website of GLASS database is freely available at http://zhanglab.ccmb.med.umich.edu/GLASS/. zhng@umich.edu Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Experimentally validated multiphysics computational model of focusing and shock wave formation in an electromagnetic lithotripter.

    Science.gov (United States)

    Fovargue, Daniel E; Mitran, Sorin; Smith, Nathan B; Sankin, Georgy N; Simmons, Walter N; Zhong, Pei

    2013-08-01

    A multiphysics computational model of the focusing of an acoustic pulse and subsequent shock wave formation that occurs during extracorporeal shock wave lithotripsy is presented. In the electromagnetic lithotripter modeled in this work the focusing is achieved via a polystyrene acoustic lens. The transition of the acoustic pulse through the solid lens is modeled by the linear elasticity equations and the subsequent shock wave formation in water is modeled by the Euler equations with a Tait equation of state. Both sets of equations are solved simultaneously in subsets of a single computational domain within the BEARCLAW framework which uses a finite-volume Riemann solver approach. This model is first validated against experimental measurements with a standard (or original) lens design. The model is then used to successfully predict the effects of a lens modification in the form of an annular ring cut. A second model which includes a kidney stone simulant in the domain is also presented. Within the stone the linear elasticity equations incorporate a simple damage model.

  13. Fuzzy Supervisor Approach Design Based-Switching Controller for Pumping Station: Experimental Validation

    Directory of Open Access Journals (Sweden)

    Wael Chakchouk

    2017-01-01

    Full Text Available This paper proposes a discrete-time switching controller strategy for a hydraulic process pumping station. The proposed solution leads to improving control system performances with two tests: combination of Fuzzy-PD and PI controllers and Fuzzy-PID and PI controllers. The proposed design methodology is based on accurate model for pumping station (PS, which is developed in previous works using Fuzzy-C Means (FCM algorithm. The control law design is based on switching control; a fuzzy supervisor manages the switching from one to another and regulates the rate of participation of each order, in order to satisfy various objectives of a stable pumping station like the asymptotic stability of the tracking error. To validate the proposed solution, experimental tests are made and analyzed. Compared to the conventional PI and fuzzy logic (FL approaches, the results show that the switching controller allows exhibiting excellent transient response over a wide range of operating conditions and especially is easier to be implemented in practice.

  14. Activity plan for activity E-20-81: development and experimental validation of crevice corrosion models

    Energy Technology Data Exchange (ETDEWEB)

    Farmer, J C

    1999-12-28

    Alloy 22 [UNS N06022] is now being considered for construction of high level waste containers to be emplaced at the potential repository at Yucca Mountain or elsewhere. In essence, this alloy is 21% Cr, 13% Mo, 4% Fe, 3% W, 2% Co, with the balance being Ni. Variants without tungsten are also being considered. Detailed mechanistic models are being developed to account for the corrosion of Alloy 22 surfaces in crevices that will inevitably form. Such occluded areas experience substantial decreases in pH, with corresponding elevations in chloride concentration. Other relevant materials will also be investigated: nickel-based alloys such as Alloys 825, 625, C-4, C-276 and 59; titanium-based alloys such as Grades 12, 7 and 16, carbon steels such as A516 Grade 55; stainless steels such as 304, 304L, 316, 316L and 316NG; various copper-based alloys; and any materials that would serve as crevice formers (rock, thermally-sprayed ceramics, etc.). Experimental work has been undertaken to validate the crevice corrosion model, including parallel studies with 304 stainless steel. The crevice corrosion model is described in detail in scientific notebooks of the Principal Investigator, as well as other publications. Codes will be prepared in accordance with the YMP QP entitled ''Software Quality Assurance'' (033-YMP-QP 12.0).

  15. Design and Experimental Validation for Direct-Drive Fault-Tolerant Permanent-Magnet Vernier Machines

    Science.gov (United States)

    Liu, Guohai; Yang, Junqin; Chen, Ming; Chen, Qian

    2014-01-01

    A fault-tolerant permanent-magnet vernier (FT-PMV) machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs). This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM), the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis. PMID:25045729

  16. Spatiotemporally Representative and Cost-Efficient Sampling Design for Validation Activities in Wanglang Experimental Site

    Directory of Open Access Journals (Sweden)

    Gaofei Yin

    2017-11-01

    Full Text Available Spatiotemporally representative Elementary Sampling Units (ESUs are required for capturing the temporal variations in surface spatial heterogeneity through field measurements. Since inaccessibility often coexists with heterogeneity, a cost-efficient sampling design is mandatory. We proposed a sampling strategy to generate spatiotemporally representative and cost-efficient ESUs based on the conditioned Latin hypercube sampling scheme. The proposed strategy was constrained by multi-temporal Normalized Difference Vegetation Index (NDVI imagery, and the ESUs were limited within a sampling feasible region established based on accessibility criteria. A novel criterion based on the Overlapping Area (OA between the NDVI frequency distribution histogram from the sampled ESUs and that from the entire study area was used to assess the sampling efficiency. A case study in Wanglang National Nature Reserve in China showed that the proposed strategy improves the spatiotemporally representativeness of sampling (mean annual OA = 74.7% compared to the single-temporally constrained (OA = 68.7% and the random sampling (OA = 63.1% strategies. The introduction of the feasible region constraint significantly reduces in-situ labour-intensive characterization necessities at expenses of about 9% loss in the spatiotemporal representativeness of the sampling. Our study will support the validation activities in Wanglang experimental site providing a benchmark for locating the nodes of automatic observation systems (e.g., LAINet which need a spatially distributed and temporally fixed sampling design.

  17. Experimental Validation of Various Temperature Modells for Semi-Physical Tyre Model Approaches

    Science.gov (United States)

    Hackl, Andreas; Scherndl, Christoph; Hirschberg, Wolfgang; Lex, Cornelia

    2017-10-01

    With increasing level of complexity and automation in the area of automotive engineering, the simulation of safety relevant Advanced Driver Assistance Systems (ADAS) leads to increasing accuracy demands in the description of tyre contact forces. In recent years, with improvement in tyre simulation, the needs for coping with tyre temperatures and the resulting changes in tyre characteristics are rising significantly. Therefore, experimental validation of three different temperature model approaches is carried out, discussed and compared in the scope of this article. To investigate or rather evaluate the range of application of the presented approaches in combination with respect of further implementation in semi-physical tyre models, the main focus lies on the a physical parameterisation. Aside from good modelling accuracy, focus is held on computational time and complexity of the parameterisation process. To evaluate this process and discuss the results, measurements from a Hoosier racing tyre 6.0 / 18.0 10 LCO C2000 from an industrial flat test bench are used. Finally the simulation results are compared with the measurement data.

  18. Numerical simulation and experimental validation of arc welding of DMR-249A steel

    Directory of Open Access Journals (Sweden)

    Rishi Pamnani

    2016-08-01

    Full Text Available The thermo-mechanical attributes of DMR-249A steel weld joints manufactured by shielded metal arc welding (SMAW and activated gas tungsten arc welding (A-GTAW processes were studied using Finite Element Model (FEM simulation. The thermal gradients and residual stresses were analyzed with SYSWELD software using double ellipsoidal heat source distribution model. The numerically estimated temperature distribution was validated with online temperature measurements using thermocouples. The predicted residual stresses profile across the weld joints was compared with the values experimentally measured using non-destructive techniques. The measured and predicted thermal cycles and residual stress profile was observed to be comparable. The residual stress developed in double sided A-GTAW joint were marginally higher in comparison to five pass SMAW joint due to phase transformation associated with high heat input per weld pass for A-GTAW process. The present investigations suggest the applicability of numerical modeling as an effective approach for predicting the thermo-mechanical properties influenced by welding techniques for DMR-249A steel weld joints. The tensile, impact and micro-hardness tests were carried to compare the welds. Considering benefits of high productivity and savings of labor and cost associated with A-GTAW compared to SMAW process, the minor variation in residual stress build up of A-GTAW joint can be neglected to develop A-GTAW as qualified alternative welding technique for DMR-249A steel.

  19. Methodology for the calculation of response factors through experimental tests and validation with simulation

    Energy Technology Data Exchange (ETDEWEB)

    Martin, K.; Flores, I.; Escudero, C.; Apaolaza, A. [Construction Quality Control Laboratory of the Basque Goverment, C/Aguirrelanda no 10, 01013 Vitoria-Gasteiz (Spain); Sala, J.M. [Thermal Engineering Department, Basque Country University (UPV/EHU), Alameda Urquijo s/n, 48013 Bilbao (Spain)

    2010-04-15

    One of the most simple and intuitive methods employed to characterise a building solution in transient regime is based on the use of response factors. Its acquisition by calculation is an appropriate approach when the thermo-physical properties of the materials are known. However, in a great number of building products these data are not available and thus large errors in the calculation may be incurred, which cannot be quantified. In this work, a dynamic testing method is presented inside a guarded hot-box unit, where the response factors of a wall can be obtained without requiring the corresponding material properties. This method has been validated by means of a finite volumes simulation code for a wall which thermal characteristics are perfectly defined. Although the errors committed when adding the response factors and comparing them with the transmittance values are higher in the experiment than in the numerical analysis, there is a good agreement between the heat flows obtained experimentally and with the simulation. (author)

  20. MATLAB/Simulink Pulse-Echo Ultrasound System Simulator Based on Experimentally Validated Models.

    Science.gov (United States)

    Kim, Taehoon; Shin, Sangmin; Lee, Hyongmin; Lee, Hyunsook; Kim, Heewon; Shin, Eunhee; Kim, Suhwan

    2016-02-01

    A flexible clinical ultrasound system must operate with different transducers, which have characteristic impulse responses and widely varying impedances. The impulse response determines the shape of the high-voltage pulse that is transmitted and the specifications of the front-end electronics that receive the echo; the impedance determines the specification of the matching network through which the transducer is connected. System-level optimization of these subsystems requires accurate modeling of pulse-echo (two-way) response, which in turn demands a unified simulation of the ultrasonics and electronics. In this paper, this is realized by combining MATLAB/Simulink models of the high-voltage transmitter, the transmission interface, the acoustic subsystem which includes wave propagation and reflection, the receiving interface, and the front-end receiver. To demonstrate the effectiveness of our simulator, the models are experimentally validated by comparing the simulation results with the measured data from a commercial ultrasound system. This simulator could be used to quickly provide system-level feedback for an optimized tuning of electronic design parameters.

  1. Time Reversal UWB Communication System: A Novel Modulation Scheme with Experimental Validation

    Directory of Open Access Journals (Sweden)

    I. H. Naqvi

    2010-01-01

    Full Text Available A new modulation scheme is proposed for a time reversal (TR ultra wide-band (UWB communication system. The new modulation scheme uses the binary pulse amplitude modulation (BPAM and adds a new level of modulation to increase the data rate of a TR UWB communication system. Multiple data bits can be transmitted simultaneously with a cost of little added interference. Bit error rate (BER performance and the maximum achievable data rate of the new modulation scheme are theoretically analyzed. Two separate measurement campaigns are carried out to analyze the proposed modulation scheme. In the first campaign, the frequency responses of a typical indoor channel are measured and the performance is studied by the simulations using the measured frequency responses. Theoretical and the simulative performances are in strong agreement with each other. Furthermore, the BER performance of the proposed modulation scheme is compared with the performance of existing modulation schemes. It is shown that the proposed modulation scheme outperforms QAM and PAM for M≥4 in an AWGN channel. In the second campaign, an experimental validation of the proposed modulation scheme is done. It is shown that the performances with the two measurement campaigns are in good agreement.

  2. Fast Hybrid MPPT Technique for Photovoltaic Applications: Numerical and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Gianluca Aurilio

    2014-01-01

    Full Text Available In PV applications, under mismatching conditions, it is necessary to adopt a maximum power point tracking (MPPT technique which is able to regulate not only the voltages of the PV modules of the array but also the DC input voltage of the inverter. Such a technique can be considered a hybrid MPPT (HMPPT technique since it is neither only distributed on the PV modules of the PV array or only centralized at the input of the inverter. In this paper a new HMPPT technique is presented and discussed. Its main advantages are the high MPPT efficiency and the high speed of tracking which are obtained by means of a fast estimate of the optimal values of PV modules voltages and of the input inverter voltage. The new HMPPT technique is compared with simple HMPPT techniques based on the scan of the power versus voltage inverter input characteristic. The theoretical analysis and the results of numerical simulations are widely discussed. Moreover, a laboratory test system, equipped with PV emulators, has been realized and used in order to experimentally validate the proposed technique.

  3. Theoretical modeling and experimental validation of transport and separation properties of carbon nanotube electrospun membrane distillation

    KAUST Repository

    Lee, Jung Gil

    2016-12-27

    Developing a high flux and selective membrane is required to make membrane distillation (MD) a more attractive desalination process. Amongst other characteristics membrane hydrophobicity is significantly important to get high vapor transport and low wettability. In this study, a laboratory fabricated carbon nanotubes (CNTs) composite electrospun (E-CNT) membrane was tested and has showed a higher permeate flux compared to poly(vinylidene fluoride-co-hexafluoropropylene) (PH) electrospun membrane (E-PH membrane) in a direct contact MD (DCMD) configuration. Only 1% and 2% of CNTs incorporation resulted in an enhanced permeate flux with lower sensitivity to feed salinity while treating a 35 and 70 g/L NaCl solutions. Experimental results and the mechanisms of E-CNT membrane were validated by a proposed new step-modeling approach. The increased vapor transport in E-CNT membranes could not be elucidated by an enhancement of mass transfer only at a given physico-chemical properties. However, the theoretical modeling approach considering the heat and mass transfers simultaneously enabled to explain successfully the enhanced flux in the DCMD process using E-CNT membranes. This indicates that both mass and heat transfers improved by CNTs are attributed to the enhanced vapor transport in the E-CNT membrane.

  4. Toward an experimental validation of new AO concepts for future E-ELT instrumentation

    Science.gov (United States)

    El Hadi, K.; Fusco, T.; Le Roux, B.

    2012-07-01

    For the last few years, LAM has been carrying out several R&D activities in Adaptive Optics (AO) instrumentation for Extremely Large Telescopes (ELTs). In the European ELT framework, a multi-purpose AO bench is developed to allow the experimental validation of new instrumental concepts dedicated to the next generation of ELTs. It is based on the use of a Shack-Hartmann wave-front sensor in front of a 140 actuators micro-deformable mirror (Boston Micromachines), dedicated to “low orders” modes, while a Pyramid wave-front sensor (PWFS) will be combined to a Liquid Crystal Spatial Light Modulator for “high orders” correction. Both systems could be merged in a two stages AO concept allowing to study the coupling of a telescope pre-correction using a dedicated large M4 deformable mirror and a post focal high order AO system. Analysis and optimisation of the spatial and temporal splits of the AO correction between the two systems is therefore essential. Finally, we will use the world’s fastest and most sensitive camera system OCAM (developed at LAM) coupled with the pyramid , to demonstrate the concept of a fast and hyper-sensitive PWFS (up to 100x100 sub-pupils) dedicated to the first generation instruments for ELTs.

  5. Design and experimental validation for direct-drive fault-tolerant permanent-magnet vernier machines.

    Science.gov (United States)

    Liu, Guohai; Yang, Junqin; Chen, Ming; Chen, Qian

    2014-01-01

    A fault-tolerant permanent-magnet vernier (FT-PMV) machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs). This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM), the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis.

  6. Experimental validation and docking studies of flavone derivatives on aldose reductase involved in diabetic retinopathy, neuropathy, and nephropathy

    OpenAIRE

    Sekhar, Pagadala Nataraj; Kishor, P. B. Kavi; P. K. Zubaidha; Hashmi, A. M; Kadam, T. A.; Anandareddy, Lakkireddy; De Maeyer, Marc; Kumar, K. Praveen; Bhaskar, B. Vijaya; Munichandrababu, T; Jayasree, G; Narayana, P. V. B. S; Gyananath, G

    2011-01-01

    The enzyme aldoreductase which plays an important role in pathogenesis of diabetic retinopathy, neuropathy, and nephropathy was purified from bovine lens, and its inhibitory activity was studied with the synthesized flavone derivatives 1-(2-hydroxyphenyl)ethanone as the starting material. Experimental study revealed that 2-chloroflavone shows less inhibitory activity of 60-70% than other flavones used in the study. To validate experimental results computationally, docking studies of new flavo...

  7. Validation of the generalized model of two-phase thermosyphon loop based on experimental measurements of volumetric flow rate

    OpenAIRE

    Bieliński Henryk

    2016-01-01

    The current paper presents the experimental validation of the generalized model of the two-phase thermosyphon loop. The generalized model is based on mass, momentum, and energy balances in the evaporators, rising tube, condensers and the falling tube. The theoretical analysis and the experimental data have been obtained for a new designed variant. The variant refers to a thermosyphon loop with both minichannels and conventional tubes. The thermosyphon loop consists of an evaporator on the low...

  8. A primer on water

    Science.gov (United States)

    Leopold, Luna Bergere; Langbein, Walter Basil

    1960-01-01

    When you open the faucet you expect water to flow. And you expect it to flow night or day, summer or winter, whether you want to fill a glass or water the lawn. It should be clean and pure, without any odor.You have seen or read about places where the water doesn't have these qualities. You may have lived in a city where you were allowed to water the lawn only during a few hours of certain days. We know a large town where the water turns brown after every big rainstorm.Beginning shortly after World War II, large areas in the Southwestern United States had a 10-year drought, and newspapers published a lot of information about its effects. Some people say that the growing demand for water will cause serious shortages over much of the country in the next 10 to 40 years. But it has always been true that while water wells and springs dry up in some places, floods may be occurring in other places at the same time.Nearly every month news stories are published describing floods somewhere in the country. In fact, every year, on the average, 75,000 persons are forced from their homes by floods. In some years, as in 1951 when the lower Kansas River experienced a great flood, half a million people are affected. To understand the reasons for such recurring distress, it is necessary to know something about rivers and about the flat land or flood plain that borders the river.Interest in water and related problems is growing as our population increases and as the use of water becomes steadily greater. To help meet this heightened interest in general information about water and its use and control is the reason this primer was written. The primer is in two parts. The first part tells about hydrology, or the science that concerns the relation of water to our earth, and the second part describes the development of water supplies and the use of water. The Geological Survey is publishing this primer in nontechnical language in the hope that it will enable the general reader to

  9. Experimental validation of a true-scale morphing flap for large civil aircraft applications

    Science.gov (United States)

    Pecora, R.; Amoroso, F.; Arena, M.; Noviello, M. C.; Rea, F.

    2017-04-01

    systems were duly analyzed and experimentally validated thus proving the overall device compliance with industrial standards and applicable airworthiness requirements.

  10. Experimental validation of response function of a NaI (Tl) detector modeled with Monte Carlo codes

    Science.gov (United States)

    Hajheidari, M. T.; Safari, M. J.; Afarideh, H.; Rouhi, H.

    2016-06-01

    This paper reports on the simulation of the response function of a Ø3"× 3" NaI (Tl) detector, using the FLUKA and MCNPX codes. These models were validated against extensive experimental data and used to benchmark various aspects of the response function. Comparisons show good agreement between both codes and experiments for different geometrical arrangements and gamma-ray energies.

  11. The BOUT Project: Validation and Benchmark of BOUT Code and Experimental Diagnostic Tools for Fusion Boundary Turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Xu, X Q

    2001-08-09

    A boundary plasma turbulence code BOUT is presented. The preliminary encouraging results have been obtained when comparing with probe measurements for a typical Ohmic discharge in CT-7 tokamak. The validation and benchmark of BOUT code and experimental diagnostic tools for fusion boundary plasma turbulence is proposed.

  12. Experimental validation of an analytical model for predicting the thermal and hydrodynamic capabilities of flat micro heat pipes

    OpenAIRE

    Revellin, Rémi; Rullière, Romuald; Lefèvre, Frédéric; Bonjour, Jocelyn

    2009-01-01

    Experimental validation of an analytical model for predicting the thermal and hydrodynamic capabilities of flat micro heat pipes correspondance: Corresponding author. Tel.: +33 4 7243 82 51; fax: +33 4 7243 8811. (Lefevre, Frederic) (Lefevre, Frederic) Centre de Thermique de Lyon (CETHIL) UMR 5008 CNRS-INSA-Univ. Lyon 1 Bat. Sadi Carnot--> , INSA-Lyon--> , F-69621 Villeurbanne Cedex--> -...

  13. Computer-Paced versus Experimenter-Paced Working Memory Span Tasks: Are They Equally Reliable and Valid?

    Science.gov (United States)

    Bailey, Heather

    2012-01-01

    Working memory span tasks are popular measures, in part, because performance on these tasks predicts performance on other measures of cognitive ability. The traditional method of span-task administration is the experimenter-paced version, whose reliability and validity have been repeatedly demonstrated. However, computer-paced span tasks are…

  14. Immune monitoring technology primer.

    Science.gov (United States)

    Dobbin, Kevin K

    2015-01-01

    Recent biotechnological developments have resulted in increasing interest in immunology biomarkers. These biomarkers have potential clinical utility in the near future as predictors of treatment response. Hence, clinical validation of these predictive markers is critical. The process of clinically validating a predictive biomarker is reviewed. Validation of a predictive biomarker requires quantifying the strength of a statistical interaction between marker and a treatment. Different study designs are considered. Clinical validation of immunology biomarkers can be demanding both in terms of time and resources, and careful planning and study design are critical.

  15. Metabolomics: A Primer.

    Science.gov (United States)

    Liu, Xiaojing; Locasale, Jason W

    2017-04-01

    Metabolomics generates a profile of small molecules that are derived from cellular metabolism and can directly reflect the outcome of complex networks of biochemical reactions, thus providing insights into multiple aspects of cellular physiology. Technological advances have enabled rapid and increasingly expansive data acquisition with samples as small as single cells; however, substantial challenges in the field remain. In this primer we provide an overview of metabolomics, especially mass spectrometry (MS)-based metabolomics, which uses liquid chromatography (LC) for separation, and discuss its utilities and limitations. We identify and discuss several areas at the frontier of metabolomics. Our goal is to give the reader a sense of what might be accomplished when conducting a metabolomics experiment, now and in the near future. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Process simulation and experimental validation of Hot Metal Gas Forming with new press hardening steels

    Science.gov (United States)

    Paul, A.; Reuther, F.; Neumann, S.; Albert, A.; Landgrebe, D.

    2017-09-01

    One field in the work of the Fraunhofer Institute for Machine Tools and Forming Technology IWU in Chemnitz is industry applied research in Hot Metal Gas Forming, combined with press hardening in one process step. In this paper the results of investigations on new press hardening steels from SSAB AB (Docol®1800 Bor and Docol®2000 Bor) are presented. Hot tensile tests recorded by the project partner (University of West Bohemia, Faculty of Mechanical Engineering) were used to create a material model for thermo-mechanical forming simulations. For this purpose the provided raw data were converted into flow curve approximations of the real stress-real strain-curves for both materials and afterwards integrated in a LS-DYNA simulation model of Hot Metal Gas Forming with all relevant boundary conditions and sub-stages. Preliminary experimental tests were carried out using a tool at room temperature to permit evaluation of the forming behaviour of Docol 1800 Bor and Docol 2000 Bor tubes as well as validation of the simulation model. Using this demonstrator geometry (outer diameter 57 mm, tube length 300 mm, wall thickness 1.5 mm), the intention was to perform a series of tests with different furnace temperatures (from 870 °C to 1035 °C), maximum internal pressures (up to 67 MPa) and pressure build-up rates (up to 40 MPa/s) to evaluate the formability of Docol 1800 Bor and Docol 2000 Bor. Selected demonstrator parts produced in that way were subsequently analysed by wall thickness and hardness measurements. The tests were carried out using the completely modernized Dunkes/AP&T HS3-1500 hydroforming press at the Fraunhofer IWU. In summary, creating a consistent simulation model with all relevant sub-stages was successfully established in LS-DYNA. The computation results show a high correlation with the experimental data regarding the thinning behaviour. The Hot Metal Gas Forming of the demonstrator geometry was successfully established as well. Different hardness values

  17. Testing the Validity of Local Flux Laws in an Experimental Eroding Landscape

    Science.gov (United States)

    Sweeney, K. E.; Roering, J. J.; Ellis, C.

    2015-12-01

    Linking sediment transport to landscape evolution is fundamental to interpreting climate and tectonic signals from topography and sedimentary deposits. Most geomorphic process laws consist of simple continuum relationships between sediment flux and local topography. However, recent work has shown that nonlocal formulations, whereby sediment flux depends on upslope conditions, are more accurate descriptions of sediment motion, particularly in steep topography. Discriminating between local and nonlocal processes in natural landscapes is complicated by the scarcity of high-resolution topographic data and by the difficulty of measuring sediment flux. To test the validity of local formulations of sediment transport, we use an experimental erosive landscape that combines disturbance-driven, diffusive sediment transport and surface runoff. We conducted our experiments in the eXperimental Landscape Model at St. Anthony Falls Laboratory a 0.5 x 0.5 m test flume filled with crystalline silica (D50 = 30μ) mixed with water to increase cohesion and preclude surface infiltration. Topography is measured with a sheet laser scanner; total sediment flux is tracked with a series of load cells. We simulate uplift (relative baselevel fall) by dropping two parallel weirs at the edges of the experiment. Diffusive sediment transport in our experiments is driven by rainsplash from a constant head drip tank fitted with 625 blunt needles of fixed diameter; sediment is mobilized both through drop impact and the subsequent runoff of the drops. To drive advective transport, we produce surface runoff via a ring of misters that produce droplets that are too small to disturb the sediment surface on impact. Using the results from five experiments that systematically vary the time of drip box rainfall relative to misting rainfall, we calculate local erosion in our experiments by differencing successive time-slices of topography and test whether these patterns are related to local topographic

  18. Partition method and experimental validation for impact dynamics of flexible multibody system

    Science.gov (United States)

    Wang, J. Y.; Liu, Z. Y.; Hong, J. Z.

    2017-11-01

    The impact problem of a flexible multibody system is a non-smooth, high-transient, and strong-nonlinear dynamic process with variable boundary. How to model the contact/impact process accurately and efficiently is one of the main difficulties in many engineering applications. The numerical approaches being used widely in impact analysis are mainly from two fields: multibody system dynamics (MBS) and computational solid mechanics (CSM). Approaches based on MBS provide a more efficient yet less accurate analysis of the contact/impact problems, while approaches based on CSM are well suited for particularly high accuracy needs, yet require very high computational effort. To bridge the gap between accuracy and efficiency in the dynamic simulation of a flexible multibody system with contacts/impacts, a partition method is presented considering that the contact body is divided into two parts, an impact region and a non-impact region. The impact region is modeled using the finite element method to guarantee the local accuracy, while the non-impact region is modeled using the modal reduction approach to raise the global efficiency. A three-dimensional rod-plate impact experiment is designed and performed to validate the numerical results. The principle for how to partition the contact bodies is proposed: the maximum radius of the impact region can be estimated by an analytical method, and the modal truncation orders of the non-impact region can be estimated by the highest frequency of the signal measured. The simulation results using the presented method are in good agreement with the experimental results. It shows that this method is an effective formulation considering both accuracy and efficiency. Moreover, a more complicated multibody impact problem of a crank slider mechanism is investigated to strengthen this conclusion.

  19. Numerical Investigation of Pressure Fluctuation in Centrifugal Pump Volute Based on SAS Model and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Qiaorui Si

    2014-02-01

    Full Text Available This paper presents an investigation of pressure fluctuation of a single-suction volute-type centrifugal pump, particularly volute casing, by using numerical and experimental methods. A new type of hybrid Reynolds-averaged Navier-Stokes/Large Eddy Simulation, referred to as the shear stress transport-scale-adaptive simulation (SAS model, is employed to study the unsteady flow. Statistical analysis method is adopted to show the pressure fluctuation intensity distribution in the volute channel. A test rig for pressure pulsation measurement is built to validate the numerical simulation results using eight transient pressure sensors in the middle section of the volute wall. Results show that the SAS model can accurately predict the inner flow field of centrifugal pumps. Radial force acting on the impeller presents a star distribution related to the blade number. Pressure fluctuation intensity is strongest near the tongue and shows irregular distribution in the pump casing. Pressure fluctuation is distributed symmetrically at the cross-section of the volute casing because the volute can eliminate the rotational movement of the liquid discharged from the impeller. Blade passing frequency and its multiples indicate the dominant frequency of the monitoring points within the volute, and the low-frequency pulsation, particularly in the shaft component, increases when it operates at off-design condition, particularly with a small flow rate. The reason is that the vortex wave is enhanced at the off-design condition, which has an effect on the axle and is presented in the shaft component in the frequency domain.

  20. Experimental validation of tonal noise control from subsonic axial fans using flow control obstructions

    Science.gov (United States)

    Gérard, Anthony; Berry, Alain; Masson, Patrice; Gervais, Yves

    2009-03-01

    This paper presents the acoustic performance of a novel approach for the passive adaptive control of tonal noise radiated from subsonic fans. Tonal noise originates from non-uniform flow that causes circumferentially varying blade forces and gives rise to a considerably larger radiated dipolar sound at the blade passage frequency (BPF) and its harmonics compared to the tonal noise generated by a uniform flow. The approach presented in this paper uses obstructions in the flow to destructively interfere with the primary tonal noise arising from various flow conditions. The acoustic radiation of the obstructions is first demonstrated experimentally. Indirect on-axis acoustic measurements are used to validate the analytical prediction of the circumferential spectrum of the blade unsteady lift and related indicators generated by the trapezoidal and sinusoidal obstructions presented in Ref. [A. Gérard, A. Berry, P. Masson, Y. Gervais, Modelling of tonal noise control from subsonic axial fans using flow control obstructions, Journal of Sound and Vibration (2008), this issue, doi: 10.1016/j.jsv.2008.09.027.] and also by cylindrical obstructions used in the literature. The directivity and sound power attenuation are then given in free field for the control of the BPF tone generated by rotor/outlet guide vane (OGV) interaction and the control of an amplified BPF tone generated by the rotor/OGV interaction with an added triangular obstruction between two outlet guide vanes to enhance the primary non-uniform flow. Global control was demonstrated in free field, attenuation up to 8.4 dB of the acoustic power at BPF has been measured. Finally, the aerodynamic performances of the automotive fan used in this study are almost not affected by the presence of the control obstruction.

  1. Design and experimental validation of an adaptive phononic crystal using highly dissipative polymeric material interface

    Science.gov (United States)

    Billon, K.; Ouisse, M.; Sadoulet-Reboul, E.; Collet, M.; Chevallier, G.; Khelif, A.

    2017-04-01

    In this paper, some numerical tools for dispersion analysis of periodic structures are presented, with a focus on the ability of the methods to deal with dissipative behaviour of the systems. An adaptive phononic crystal based on the combination of metallic parts and highly dissipative polymeric interface is designed. The system consists in an infinite periodic bidirectional waveguide. The periodic cylindrical pillars include a layer of shape memory polymer and Aluminum. The mechanical properties of the polymer depend on both temperature and frequency and can radically change from glassy to rubbery state, with various combination of high/low stiffness and high/low dissipation. A fractional derivative Zener model is used for the description of the frequency-dependent behaviour of the polymer. A 3D finite element model of the cell is developed for the design of the metamaterial. The "Shifted-Cell Operator" technique consists in a reformulation of the PDE problem by "shifting" in terms of wave number the space derivatives appearing in the mechanical behaviour operator inside the cell, while imposing continuity boundary conditions on the borders of the domain. Damping effects can easily be introduced in the system and a quadratic eigenvalue problem yields to the dispersion properties of the periodic structure. In order to validate the design and the adaptive character of the metamaterial, results issued from a full 3D model of a finite structure embedding an interface composed by a distributed set of the unit cells are presented. Various driving temperature are used to change the behaviour of the system. After this step, a comparison between the results obtained using the tunable structure simulation and the experimental results is presented. Two states are obtained by changing the temperature of the polymeric interface: at 25°C, the bandgap is visible around a selected frequency. Above the glass transition, the phononic crystal tends to behave as an homogeneous plate.

  2. Experimental validation of a method for removing the capacitive leakage artifact from electrical bioimpedance spectroscopy measurements

    Science.gov (United States)

    Buendia, R.; Seoane, F.; Gil-Pita, R.

    2010-11-01

    Often when performing electrical bioimpedance (EBI) spectroscopy measurements, the obtained EBI data present a hook-like deviation, which is most noticeable at high frequencies in the impedance plane. The deviation is due to a capacitive leakage effect caused by the presence of stray capacitances. In addition to the data deviation being remarkably noticeable at high frequencies in the phase and the reactance spectra, the measured EBI is also altered in the resistance and the modulus. If this EBI data deviation is not properly removed, it interferes with subsequent data analysis processes, especially with Cole model-based analyses. In other words, to perform any accurate analysis of the EBI spectroscopy data, the hook deviation must be properly removed. Td compensation is a method used to compensate the hook deviation present in EBI data; it consists of multiplying the obtained spectrum, Zmeas(ω), by a complex exponential in the form of exp(-jωTd). Although the method is well known and accepted, Td compensation cannot entirely correct the hook-like deviation; moreover, it lacks solid scientific grounds. In this work, the Td compensation method is revisited, and it is shown that it should not be used to correct the effect of a capacitive leakage; furthermore, a more developed approach for correcting the hook deviation caused by the capacitive leakage is proposed. The method includes a novel correcting expression and a process for selecting the proper values of expressions that are complex and frequency dependent. The correctness of the novel method is validated with the experimental data obtained from measurements from three different EBI applications. The obtained results confirm the sufficiency and feasibility of the correcting method.

  3. Verification and Validation of the PLTEMP/ANL Code for Thermal-Hydraulic Analysis of Experimental and Test Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kalimullah, M. [Argonne National Lab. (ANL), Argonne, IL (United States); Olson, Arne P. [Argonne National Lab. (ANL), Argonne, IL (United States); Feldman, E. E. [Argonne National Lab. (ANL), Argonne, IL (United States); Hanan, N. [Argonne National Lab. (ANL), Argonne, IL (United States); Dionne, B. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-04-07

    The document compiles in a single volume several verification and validation works done for the PLTEMP/ANL code during the years of its development and improvement. Some works that are available in the open literature are simply referenced at the outset, and are not included in the document. PLTEMP has been used in conversion safety analysis reports of several US and foreign research reactors that have been licensed and converted. A list of such reactors is given. Each chapter of the document deals with the verification or validation of a specific model. The model verification is usually done by comparing the code with hand calculation, Microsoft spreadsheet calculation, or Mathematica calculation. The model validation is done by comparing the code with experimental data or a more validated code like the RELAP5 code.

  4. Concurrent Validation of Experimental Army Enlisted Personnel Selection and Classification Measures

    National Research Council Canada - National Science Library

    Knapp, Deirdre J; Tremble, Trueman R

    2007-01-01

    .... This report documents the method and results of the criterion-related validation. The predictor set includes measures of cognitive ability, temperament, psychomotor skills, values, expectations...

  5. Stratification of bubbly horizontal flows: modeling and experimental validation; Stratification des ecoulements a bulles horizontaux: modelisation et validation experimentale

    Energy Technology Data Exchange (ETDEWEB)

    Bottin, M.

    2010-12-17

    Hot films and optical probes enabled the acquisition of measurements in bubbly flows at 5, 20 and 40 diameters from the inlet of the vein on the METERO facility which test section is a horizontal circular pipe of 100 mm inner diameter. The distribution of the different phases, the existence of coalescence and sedimentation mechanisms, the influence of the liquid and gas flow rates, the radial and axial evolutions are analyzed thanks to fast camera videos and numerous and varied experimental results (void fraction, bubbles sizes, interfacial area, mean and fluctuating velocities and turbulent kinetic energy of the liquid phase). Some models, based on the idea that the flow reaches an equilibrium state sufficiently far from the inlet of the pipe, were developed to simulate mean interfacial area and turbulent kinetic energy transports in bubbly flows. (author)

  6. Demonstrating Experimenter "Ineptitude" as a Means of Teaching Internal and External Validity

    Science.gov (United States)

    Treadwell, Kimberli R.H.

    2008-01-01

    Internal and external validity are key concepts in understanding the scientific method and fostering critical thinking. This article describes a class demonstration of a "botched" experiment to teach validity to undergraduates. Psychology students (N = 75) completed assessments at the beginning of the semester, prior to and immediately following…

  7. Experimental Peptide Identification Repository (EPIR): an integrated peptide-centric platform for validation and mining of tandem mass spectrometry data

    DEFF Research Database (Denmark)

    Kristensen, Dan Bach; Brønd, Jan Christian; Nielsen, Peter Aagaard

    2004-01-01

    LC MS/MS has become an established technology in proteomic studies, and with the maturation of the technology the bottleneck has shifted from data generation to data validation and mining. To address this bottleneck we developed Experimental Peptide Identification Repository (EPIR), which...... information. In the present study, the utility of EPIR and associated software tools is demonstrated on LC MS/MS data derived from a set of model proteins and complex protein mixtures derived from MCF-7 breast cancer cells. Emphasis is placed on the key strengths of EPIR, including the ability to validate...

  8. Squeaking friction phenomena in ceramic hip endoprosthesis: Modeling and experimental validation

    Science.gov (United States)

    Ouenzerfi, G.; Massi, F.; Renault, E.; Berthier, Y.

    2015-06-01

    The modern evolution of ceramic bearing surfaces for total hip arthroplasty has allowed longer implant longevity with lower amounts of osteolysis. It has been applied to younger patient expecting improved survivorship compared with traditional bearing surfaces. However, the phenomenon of an audible squeaking produced by implants during daily activities is reported as an annoying complication for patients. Although recent studies have been carried out on this topic, the origin of squeaking and the analysis of factors leading to this phenomenon are not completely identified. Numerical analyses are still not able to reproduce precisely the in vitro and in vivo observations. The lack of understanding on the physics of this issue is still an obstacle to find appropriate solutions to prevent it. In this paper, numerical and experimental approaches to reproduce squeaking are presented. A pre-stressed modal analysis is performed to identify the unstable eigenfrequencies that cause the vibrations and the perceived acoustic emission. The numerical results are validated by experiments on a laboratory test bench and the predicted frequencies are compared to the squeaking frequencies that can be found both in vitro and in vivo. The natural frequencies related to the femoral components are closer to the observed squeaking frequency. Simulations results confirmed that these vibrations are related to the stem dynamic response, which has a strong influence on the squeaking characteristic. In the other hand, the cup and the ceramic components play a main indirect role providing the frictional pair between the head and the liner. The analysis suggests that one of the possible mechanisms at the origin of squeaking is the modal coupling of two modes of vibration of the stem under frictional contact. The numerical model will allow for identifying the dominant factors and parameters affecting squeaking in order to avoid the unstable mode coupling. Squeaking can be reduced clinically by

  9. Experimental Validation of an FSW Model with an Enhanced Friction Law: Application to a Threaded Cylindrical Pin Tool

    Directory of Open Access Journals (Sweden)

    Narges Dialami

    2017-11-01

    Full Text Available This work adopts a fast and accurate two-stage computational strategy for the analysis of FSW (Friction stir welding processes using threaded cylindrical pin tools. The coupled thermo-mechanical problem is equipped with an enhanced friction model to include the effect of non-uniform pressure distribution under the pin shoulder. The overall numerical strategy is successfully validated by the experimental measurements provided by the industrial partner (Sapa. The verification of the numerical model using the experimental evidence is not only accomplished in terms of temperature evolution but also in terms of torque, longitudinal, transversal and vertical forces.

  10. PCR primers to study the diversity of expressed fungal genes encoding lignocellulolytic enzymes in soils using high-throughput sequencing.

    Directory of Open Access Journals (Sweden)

    Florian Barbi

    Full Text Available Plant biomass degradation in soil is one of the key steps of carbon cycling in terrestrial ecosystems. Fungal saprotrophic communities play an essential role in this process by producing hydrolytic enzymes active on the main components of plant organic matter. Open questions in this field regard the diversity of the species involved, the major biochemical pathways implicated and how these are affected by external factors such as litter quality or climate changes. This can be tackled by environmental genomic approaches involving the systematic sequencing of key enzyme-coding gene families using soil-extracted RNA as material. Such an approach necessitates the design and evaluation of gene family-specific PCR primers producing sequence fragments compatible with high-throughput sequencing approaches. In the present study, we developed and evaluated PCR primers for the specific amplification of fungal CAZy Glycoside Hydrolase gene families GH5 (subfamily 5 and GH11 encoding endo-β-1,4-glucanases and endo-β-1,4-xylanases respectively as well as Basidiomycota class II peroxidases, corresponding to the CAZy Auxiliary Activity family 2 (AA2, active on lignin. These primers were experimentally validated using DNA extracted from a wide range of Ascomycota and Basidiomycota species including 27 with sequenced genomes. Along with the published primers for Glycoside Hydrolase GH7 encoding enzymes active on cellulose, the newly design primers were shown to be compatible with the Illumina MiSeq sequencing technology. Sequences obtained from RNA extracted from beech or spruce forest soils showed a high diversity and were uniformly distributed in gene trees featuring the global diversity of these gene families. This high-throughput sequencing approach using several degenerate primers constitutes a robust method, which allows the simultaneous characterization of the diversity of different fungal transcripts involved in plant organic matter degradation and may

  11. A numerical model of the deep-bed drying of extruded fish feed and its experimental validation

    DEFF Research Database (Denmark)

    Haubjerg, Anders Fjeldbo; Veje, Christian; Jørgensen, Bo Nørregaard

    A deep bed drying model for the description of moisture and temperature on an individual pellet level has been developed. Experimental validation is carried out in a special designed lab batch dryer, based on recordings of average moisture content and pellet surface temperature, on the air exhaus...... side. The model comprise empirical recording of moisture desorption isotherms and semi-empirical relations for moisture diffusivity and heat and mass transfer coefficients, in particular including the effect of air temperature on moisture diffusivity....

  12. Modelling of organic Rankine cycle power systems in off-design conditions: an experimentally-validated comparative study

    OpenAIRE

    Dickes, Rémi; Dumont, Olivier; Daccord, Rémi; Quoilin, Sylvain; Lemort, Vincent

    2017-01-01

    Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development, power generation from low-grade heat sources is gaining interest and the organic Rankine cycle (ORC) is seen as one of the most promising technologies for such applications. In this paper, it is proposed to perform an experimentally-validated comparison of different modelling methods for the of...

  13. Validation of the actuator disc and actuator line techniques for yawed rotor flows using the New Mexico experimental data

    DEFF Research Database (Denmark)

    Breton, S. P.; Shen, Wen Zhong; Ivanell, S.

    2017-01-01

    Experimental data acquired in the New Mexico experiment on a yawed 4.5m diameter rotor model turbine are used here to validate the actuator line (AL) and actuator disc (AD) models implemented in the Large Eddy Simulation code EllipSys3D in terms of loading and velocity field. Even without modelling...... and blade loading of the New Mexico rotor under yawed inflow....

  14. REVIEW OF EXPERIMENTAL CAPABILITIES AND HYDRODYNAMIC DATA FOR VALIDATION OF CFD-BASED PREDICTIONS FOR SLURRY BUBBLE COLUMN REACTORS

    Energy Technology Data Exchange (ETDEWEB)

    Donna Post Guillen; Daniel S. Wendt; Steven P. Antal; Michael Z. Podowski

    2007-11-01

    The purpose of this paper is to document the review of several open-literature sources of both experimental capabilities and published hydrodynamic data to aid in the validation of a Computational Fluid Dynamics (CFD) based model of a slurry bubble column (SBC). The review included searching the Web of Science, ISI Proceedings, and Inspec databases, internet searches as well as other open literature sources. The goal of this study was to identify available experimental facilities and relevant data. Integral (i.e., pertaining to the SBC system), as well as fundamental (i.e., separate effects are considered), data are included in the scope of this effort. The fundamental data is needed to validate the individual mechanistic models or closure laws used in a Computational Multiphase Fluid Dynamics (CMFD) simulation of a SBC. The fundamental data is generally focused on simple geometries (i.e., flow between parallel plates or cylindrical pipes) or custom-designed tests to focus on selected interfacial phenomena. Integral data covers the operation of a SBC as a system with coupled effects. This work highlights selected experimental capabilities and data for the purpose of SBC model validation, and is not meant to be an exhaustive summary.

  15. REVIEW OF EXPERIMENTAL CAPABILITIES AND HYDRODYNAMIC DATA FOR VALIDATION OF CFD BASED PREDICTIONS FOR SLURRY BUBBLE COLUMN REACTORS

    Energy Technology Data Exchange (ETDEWEB)

    Donna Post Guillen; Daniel S. Wendt

    2007-11-01

    The purpose of this paper is to document the review of several open-literature sources of both experimental capabilities and published hydrodynamic data to aid in the validation of a Computational Fluid Dynamics (CFD) based model of a slurry bubble column (SBC). The review included searching the Web of Science, ISI Proceedings, and Inspec databases, internet searches as well as other open literature sources. The goal of this study was to identify available experimental facilities and relevant data. Integral (i.e., pertaining to the SBC system), as well as fundamental (i.e., separate effects are considered), data are included in the scope of this effort. The fundamental data is needed to validate the individual mechanistic models or closure laws used in a Computational Multiphase Fluid Dynamics (CMFD) simulation of a SBC. The fundamental data is generally focused on simple geometries (i.e., flow between parallel plates or cylindrical pipes) or custom-designed tests to focus on selected interfacial phenomena. Integral data covers the operation of a SBC as a system with coupled effects. This work highlights selected experimental capabilities and data for the purpose of SBC model validation, and is not meant to be an exhaustive summary.

  16. Computer-aided design of liposomal drugs: In silico prediction and experimental validation of drug candidates for liposomal remote loading.

    Science.gov (United States)

    Cern, Ahuva; Barenholz, Yechezkel; Tropsha, Alexander; Goldblum, Amiram

    2014-01-10

    Previously we have developed and statistically validated Quantitative Structure Property Relationship (QSPR) models that correlate drugs' structural, physical and chemical properties as well as experimental conditions with the relative efficiency of remote loading of drugs into liposomes (Cern et al., J. Control. Release 160 (2012) 147-157). Herein, these models have been used to virtually screen a large drug database to identify novel candidate molecules for liposomal drug delivery. Computational hits were considered for experimental validation based on their predicted remote loading efficiency as well as additional considerations such as availability, recommended dose and relevance to the disease. Three compounds were selected for experimental testing which were confirmed to be correctly classified by our previously reported QSPR models developed with Iterative Stochastic Elimination (ISE) and k-Nearest Neighbors (kNN) approaches. In addition, 10 new molecules with known liposome remote loading efficiency that were not used by us in QSPR model development were identified in the published literature and employed as an additional model validation set. The external accuracy of the models was found to be as high as 82% or 92%, depending on the model. This study presents the first successful application of QSPR models for the computer-model-driven design of liposomal drugs. © 2013.

  17. Ecological validity and infant research: An example from an experimental study on object individuation with familiar objects in 8-month-old infants

    DEFF Research Database (Denmark)

    Krøjgaard, Peter

      The concept of ecological validity is central when considering an ecological approach to experimental research. However, the concept of ecological validity seem to occur rather seldom in discussion sections in journal articles on experimental infant reseach. In this conference presentation I...... shall attempt to apply an analysis based on the concept of ecological validity on a specific experimental study within the field of infant cognition. I will attempt to show that such an analysis can be worthwhile.The presentation falls in three sections. The first section is a presentation...... of ecological validity. It is argued, that the negative results obtained may at least in part be explained by incorporating the concept of ecological validity into the analysis, and hence that the concept of ecological validity can indeed be a usefull analytical tool when discussing experimental infant research....

  18. Experimental validation of a rate-based model for CO2 capture using an AMP solution

    DEFF Research Database (Denmark)

    Gabrielsen, Jostein; Svendsen, H. F.; Michelsen, Michael Locht

    2007-01-01

    Detailed experimental data, including temperature profiles over the absorber, for a carbon dioxide (CO"2) absorber with structured packing in an integrated laboratory pilot plant using an aqueous 2-amino-2-methyl-1-propanol (AMP) solution are presented. The experimental gas-liquid material balance...

  19. Experimental Validation of the Transverse Shear Behavior of a Nomex Core for Sandwich Panels

    Science.gov (United States)

    Farooqi, M. I.; Nasir, M. A.; Ali, H. M.; Ali, Y.

    2017-05-01

    This work deals with determination of the transverse shear moduli of a Nomex® honeycomb core of sandwich panels. Their out-of-plane shear characteristics depend on the transverse shear moduli of the honeycomb core. These moduli were determined experimentally, numerically, and analytically. Numerical simulations were performed by using a unit cell model and three analytical approaches. Analytical calculations showed that two of the approaches provided reasonable predictions for the transverse shear modulus as compared with experimental results. However, the approach based upon the classical lamination theory showed large deviations from experimental data. Numerical simulations also showed a trend similar to that resulting from the analytical models.

  20. Numerical simulation and experimental validation of internal heat exchanger influence on CO{sub 2} trans-critical cycle performance

    Energy Technology Data Exchange (ETDEWEB)

    Rigola, Joaquim; Ablanque, Nicolas; Perez-Segarra, Carlos D.; Oliva, Assensi [Centre Tecnologic de Transferencia de Calor (CTTC), Universitat Politecnica de Catalunya (UPC), ETSEIAT, C. Colom 11, 08222 Terrassa (Barcelona) (Spain)

    2010-06-15

    The present paper is a numerical and experimental comparative study of the whole vapour compression refrigerating cycle in general, and reciprocating compressors in particular, with the aim of showing the possibilities that CO{sub 2} offers for commercial refrigeration, considering a single-stage trans-critical cycle using semi-hermetic reciprocating compressors under small cooling capacity systems. The present work is focussed on the influence of using an internal heat exchanger (IHX) in order to improve the cycle performance under real working conditions. In order to validate the numerical results, an experimental unit specially designed and built to analyze trans-critical refrigerating equipments considering IHX has been built. Both numerical results and experimental data show reasonable good agreement, while the comparative global values conclude the improvement of cooling capacity and COP when IHX is considered in the CO{sub 2} trans-critical cycle. (author)

  1. Validations and improvements of airfoil trailing-edge noise prediction models using detailed experimental data

    DEFF Research Database (Denmark)

    Kamruzzaman, M.; Lutz, Th.; Würz, W.

    2012-01-01

    This paper describes an extensive assessment and a step by step validation of different turbulent boundary-layer trailing-edge noise prediction schemes developed within the European Union funded wind energy project UpWind. To validate prediction models, measurements of turbulent boundary...... and far-field radiated noise models capture well the measured peak amplitude level as well as the peak position if the turbulence noise source parameters are estimated properly including turbulence anisotropy effects. Large eddy simulation based computational aeroacoustic computations show good agreements...

  2. Design and Experimental Validation of Hydraulic Yaw System for Multi MW Wind Turbine

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Andersen, Torben Ole

    2013-01-01

    market. A hydraulic yaw system is such a new technology, and so a mathematical model of the full scale system and test rig system is derived and compared to measurements from the system. This is done in order to have a validated model, which wind turbine manufacturers may use for test in their simulation...... environment. The model and the test rig are tested up against different design load cases and the results are compared. The experiments show that the model is valid for comparing the overall dynamics of the hydraulic yaw system. Based on the results it is concluded that the model derived is suitable...

  3. Task-Difficulty Homeostasis in Car Following Models: Experimental Validation Using Self-Paced Visual Occlusion

    National Research Council Canada - National Science Library

    Pekkanen, Jami; Lappi, Otto; Itkonen, Teemu H; Summala, Heikki

    2017-01-01

    ...) model, by dynamically changing driving parameters as function of driver capability. We examined assumptions of these models experimentally using a self-paced visual occlusion paradigm in a simulated car following task...

  4. The impact of crowd noise on officiating in Muay Thai: achieving external validity in an experimental setting

    Directory of Open Access Journals (Sweden)

    Tony D Myers

    2012-09-01

    Full Text Available Numerous factors have been proposed to explain the home advantage in sport. Several authors have suggested that a partisan home crowd enhances home advantage and that this is at least in part a consequence of their influence on officiating. However, while experimental studies examining this phenomenon have high levels of internal validity (since only the ‘crowd noise’ intervention is allowed to vary, they suffer from a lack of external validity, with decision-making in a laboratory setting typically bearing little resemblance to decision-making in live sports settings. Conversely, observational and quasi-experimental studies with high levels of external validity suffer from low levels of internal validity as countless factors besides crowd noise vary. The present study provides a unique opportunity to address these criticisms, by conducting a controlled experiment on the impact of crowd noise on officiating in a live tournament setting. Seventeen qualified judges officiated on thirty Thai boxing bouts in a live international tournament setting featuring ‘home’ and ‘away’ boxers. In each bout, judges were randomised into a ‘noise’ (live sound or ‘no crowd noise’ (noise cancelling headphones and white noise condition, resulting in 59 judgements in the ‘no crowd noise’ and 61 in the ‘crowd noise’ condition. The results provide the first experimental evidence of the impact of live crowd noise on officials in sport. A cross-classified statistical model indicated that crowd noise had a statistically significant impact, equating to just over half a point per bout (in the context of five round bouts with the ‘ten point must’ scoring system shared with professional boxing. The practical significance of the findings, their implications for officiating and for the future conduct of crowd noise studies are discussed.

  5. The impact of crowd noise on officiating in muay thai: achieving external validity in an experimental setting.

    Science.gov (United States)

    Myers, Tony; Balmer, Nigel

    2012-01-01

    Numerous factors have been proposed to explain the home advantage in sport. Several authors have suggested that a partisan home crowd enhances home advantage and that this is at least in part a consequence of their influence on officiating. However, while experimental studies examining this phenomenon have high levels of internal validity (since only the "crowd noise" intervention is allowed to vary), they suffer from a lack of external validity, with decision-making in a laboratory setting typically bearing little resemblance to decision-making in live sports settings. Conversely, observational and quasi-experimental studies with high levels of external validity suffer from low levels of internal validity as countless factors besides crowd noise vary. The present study provides a unique opportunity to address these criticisms, by conducting a controlled experiment on the impact of crowd noise on officiating in a live tournament setting. Seventeen qualified judges officiated on thirty Thai boxing bouts in a live international tournament setting featuring "home" and "away" boxers. In each bout, judges were randomized into a "noise" (live sound) or "no crowd noise" (noise-canceling headphones and white noise) condition, resulting in 59 judgments in the "no crowd noise" and 61 in the "crowd noise" condition. The results provide the first experimental evidence of the impact of live crowd noise on officials in sport. A cross-classified statistical model indicated that crowd noise had a statistically significant impact, equating to just over half a point per bout (in the context of five round bouts with the "10-point must" scoring system shared with professional boxing). The practical significance of the findings, their implications for officiating and for the future conduct of crowd noise studies are discussed.

  6. Validation of raw experimental data during shoting at the LIL facility

    Science.gov (United States)

    Henry, Olivier; Domin, Vincent; Romary, Philippe; Raffestin, Didier

    2012-10-01

    The LIL (Laser Integration Line) facility at CESTA (Aquitaine, France) is a facility allowing the delivery of 20 kJ at 3φ. The experiment system includes 13 diagnostics. The facility must be able to deliver, within one hour following shoting, all the results of the plasma diagnostics, alignment images and laser diagnostic measurements. These results have to be guaranteed in terms of conformity to the request and quality of measurement. The LIL has developed a tool for the visualisation, analysis and validation of the data. The software is written in the Delphi language for the main body. The configuration is based on XML files. It is thus possible to re-read the external analysis modules in Python (the language used on the future LMJ). The software is built on three pillars: definition of a validation model prior to the campaign, basic physical models to qualify the signal as compliant and exploitable, and inter-comparison of the shoting and signals over a given campaign or period. Validation of the raw plasma data must serve to validate and guarantee performances, assure the conformity of the PD configuration to the request from the client, check the consistency of measurements, trigger corrective maintenance if necessary.

  7. Experimental validation of a dynamic waste heat recovery system model for control purposes

    NARCIS (Netherlands)

    Feru, E.; Kupper, F.; Rojer, C.; Seykens, X.L.J.; Scappin, F.; Willems, F.P.T.; Smits, J.; Jager, B. de; Steinbuch, M.

    2013-01-01

    This paper presents the identification and validation of a dynamic Waste Heat Recovery (WHR) system model. Driven by upcoming CO2 emission targets and increasing fuel costs, engine exhaust gas heat utilization has recently attracted much attention to improve fuel efficiency, especially for

  8. Incremental Validity of Thinking Styles in Predicting Academic Achievements: An Experimental Study in Hypermedia Learning Environments

    Science.gov (United States)

    Fan, Weiqiao; Zhang, Li-Fang; Watkins, David

    2010-01-01

    The study examined the incremental validity of thinking styles in predicting academic achievement after controlling for personality and achievement motivation in the hypermedia-based learning environment. Seventy-two Chinese college students from Shanghai, the People's Republic of China, took part in this instructional experiment. The…

  9. Experimental Construct Validity in the Evaluation of Cognitive and Behavioral Treatments for Depression.

    Science.gov (United States)

    McNamara, Kathleen; Horan, John J.

    1986-01-01

    Distilled versions of Beck's cognitive and Lewinsohn's behavioral treatments for depression were crossed in a 2 x 2 design that included combined and high-demand control treatments. The obtained pattern of convergent and divergent outcomes indicates considerable construct-valid strength for cognitive therapy applied to a moderately depressed…

  10. Development, characterization and experimental validation of a cultivated sunflower (Helianthus annuus L.) gene expression oligonucleotide microarray.

    Science.gov (United States)

    Fernandez, Paula; Soria, Marcelo; Blesa, David; DiRienzo, Julio; Moschen, Sebastian; Rivarola, Maximo; Clavijo, Bernardo Jose; Gonzalez, Sergio; Peluffo, Lucila; Príncipi, Dario; Dosio, Guillermo; Aguirrezabal, Luis; García-García, Francisco; Conesa, Ana; Hopp, Esteban; Dopazo, Joaquín; Heinz, Ruth Amelia; Paniego, Norma

    2012-01-01

    Oligonucleotide-based microarrays with accurate gene coverage represent a key strategy for transcriptional studies in orphan species such as sunflower, H. annuus L., which lacks full genome sequences. The goal of this study was the development and functional annotation of a comprehensive sunflower unigene collection and the design and validation of a custom sunflower oligonucleotide-based microarray. A large scale EST (>130,000 ESTs) curation, assembly and sequence annotation was performed using Blast2GO (www.blast2go.de). The EST assembly comprises 41,013 putative transcripts (12,924 contigs and 28,089 singletons). The resulting Sunflower Unigen Resource (SUR version 1.0) was used to design an oligonucleotide-based Agilent microarray for cultivated sunflower. This microarray includes a total of 42,326 features: 1,417 Agilent controls, 74 control probes for sunflower replicated 10 times (740 controls) and 40,169 different non-control probes. Microarray performance was validated using a model experiment examining the induction of senescence by water deficit. Pre-processing and differential expression analysis of Agilent microarrays was performed using the Bioconductor limma package. The analyses based on p-values calculated by eBayes (psunflower unigene collection, and a custom, validated sunflower oligonucleotide-based microarray using Agilent technology. Both the curated unigene collection and the validated oligonucleotide microarray provide key resources for sunflower genome analysis, transcriptional studies, and molecular breeding for crop improvement.

  11. Conditions for the Validity of Faraday's Law of Induction and Their Experimental Confirmation

    Science.gov (United States)

    Lopez-Ramos, A.; Menendez, J. R.; Pique, C.

    2008-01-01

    This paper, as its main didactic objective, shows the conditions needed for the validity of Faraday's law of induction. Inadequate comprehension of these conditions has given rise to several paradoxes about the issue; some are analysed and solved in this paper in the light of the theoretical deduction of the induction law. Furthermore, an…

  12. Anger & Aggression Management in Young Adolescents: An Experimental Validation of the SCARE Program.

    Science.gov (United States)

    Herrmann, D. Scott; McWhirter, J. Jeffries

    2003-01-01

    A study examined the validity of the SCARE program; an anger management program developed with high school students. Adolescents (n=207) exposed to the SCARE program had significantly lower levels of anger and aggression, slightly higher anger control, and lower scores on aggressive and violent attitudes a year after exposure. (Contains…

  13. Development, characterization and experimental validation of a cultivated sunflower (Helianthus annuus L. gene expression oligonucleotide microarray.

    Directory of Open Access Journals (Sweden)

    Paula Fernandez

    Full Text Available Oligonucleotide-based microarrays with accurate gene coverage represent a key strategy for transcriptional studies in orphan species such as sunflower, H. annuus L., which lacks full genome sequences. The goal of this study was the development and functional annotation of a comprehensive sunflower unigene collection and the design and validation of a custom sunflower oligonucleotide-based microarray. A large scale EST (>130,000 ESTs curation, assembly and sequence annotation was performed using Blast2GO (www.blast2go.de. The EST assembly comprises 41,013 putative transcripts (12,924 contigs and 28,089 singletons. The resulting Sunflower Unigen Resource (SUR version 1.0 was used to design an oligonucleotide-based Agilent microarray for cultivated sunflower. This microarray includes a total of 42,326 features: 1,417 Agilent controls, 74 control probes for sunflower replicated 10 times (740 controls and 40,169 different non-control probes. Microarray performance was validated using a model experiment examining the induction of senescence by water deficit. Pre-processing and differential expression analysis of Agilent microarrays was performed using the Bioconductor limma package. The analyses based on p-values calculated by eBayes (p<0.01 allowed the detection of 558 differentially expressed genes between water stress and control conditions; from these, ten genes were further validated by qPCR. Over-represented ontologies were identified using FatiScan in the Babelomics suite. This work generated a curated and trustable sunflower unigene collection, and a custom, validated sunflower oligonucleotide-based microarray using Agilent technology. Both the curated unigene collection and the validated oligonucleotide microarray provide key resources for sunflower genome analysis, transcriptional studies, and molecular breeding for crop improvement.

  14. Onchocercal DNA amplification using beta actin gene primers ...

    African Journals Online (AJOL)

    Detecting any parts of the parasite stages such as antigens, enzymes and nucleic acids (DNA and RNA) is a definitive diagnosis and highly sensitive. This study was to evaluate the diagnostic reliability of the beta actin gene primer pair to confirm its suitability for validating presence or absence of skin microfilaria at ...

  15. Taxon-specific PCR primers to detect two inconspicuous arbuscular mycorrhizal fungi from temperate agricultural grassland

    NARCIS (Netherlands)

    Gamper, H.A.; Leuchtmann, A.

    2007-01-01

    Taxon-specific polymerase chain reaction (PCR) primers enable detection of arbuscular mycorrhizal fungi (AMF, Glomeromycota) in plant roots where the fungi lack discriminative morphological and biochemical characters. We designed and validated pairs of new PCR primers targeted to the flanking

  16. Experimental validation of finite element model analysis of a steel frame in simulated post-earthquake fire environments

    Science.gov (United States)

    Huang, Ying; Bevans, W. J.; Xiao, Hai; Zhou, Zhi; Chen, Genda

    2012-04-01

    During or after an earthquake event, building system often experiences large strains due to shaking effects as observed during recent earthquakes, causing permanent inelastic deformation. In addition to the inelastic deformation induced by the earthquake effect, the post-earthquake fires associated with short fuse of electrical systems and leakage of gas devices can further strain the already damaged structures during the earthquakes, potentially leading to a progressive collapse of buildings. Under these harsh environments, measurements on the involved building by various sensors could only provide limited structural health information. Finite element model analysis, on the other hand, if validated by predesigned experiments, can provide detail structural behavior information of the entire structures. In this paper, a temperature dependent nonlinear 3-D finite element model (FEM) of a one-story steel frame is set up by ABAQUS based on the cited material property of steel from EN 1993-1.2 and AISC manuals. The FEM is validated by testing the modeled steel frame in simulated post-earthquake environments. Comparisons between the FEM analysis and the experimental results show that the FEM predicts the structural behavior of the steel frame in post-earthquake fire conditions reasonably. With experimental validations, the FEM analysis of critical structures could be continuously predicted for structures in these harsh environments for a better assistant to fire fighters in their rescue efforts and save fire victims.

  17. Heat transfer in plate heat exchanger channels: Experimental validation of selected correlation equations

    Directory of Open Access Journals (Sweden)

    Cieśliński Janusz T.

    2016-09-01

    Full Text Available This study is focused on experimental investigation of selected type of brazed plate heat exchanger (PHEx. The Wilson plot approach was applied in order to estimate heat transfer coefficients for the PHEx passages. The main aim of the paper was to experimentally check ability of several correlations published in the literature to predict heat transfer coefficients by comparison experimentally obtained data with appropriate predictions. The results obtained revealed that Hausen and Dittus-Boelter correlations underestimated heat transfer coefficient for the tested PHEx by an order of magnitude. The Aspen Plate code overestimated heat transfer coefficient by about 50%, while Muley-Manglik correlation overestimated it from 1% to 25%, dependent on the value of Reynolds number and hot or cold liquid side.

  18. Modeling and experimental validation of TCE abatement and ozone formation with non thermal plasma

    OpenAIRE

    Vandenbroucke, Arne; Aerts, Robby; Morent, Rino; De Geyter, Nathalie; Bogaerts, Annemie; Leys, Christophe

    2012-01-01

    In this study, the formation of ozone and the abatement of trichloroethylene (TCE) with non thermal plasma was experimentally and theoretically investigated. The model predicts that the ozone formation increases with the energy deposition and decreases with the relative humidity (RH) of the air, which is qualitatively in agreement with experimental data. For an energy deposition of 0.136 J/cm³, the abatement of 1000 ppm TCE in air with 5 % RH is dominated by atomic oxygen and to a lesser exte...

  19. Vibration of a continuous beam excited by a moving mass and experimental validation

    Science.gov (United States)

    Stancioiu, D.; James, S.; Ouyang, H.; Mottershead, J. E.

    2009-08-01

    The work presented in this paper deals with the vibration of a continuous slender beam excited by a mass moving at various speeds along it. An experimental model is designed and set up to study this problem. This model, which consists of a four-span continuous beam traversed by a moving mass at a constant speed, is used to build a theoretical model for the supporting structure. A series of tests designed to assess the accuracy of the model are carried out. The final section of the paper is dedicated to the numerical and experimental results and discussion.

  20. Experimental Validation of Energy Resources Integration in Microgrids via Distributed Predictive Control

    DEFF Research Database (Denmark)

    Mantovani, Giancarlo; Costanzo, Giuseppe Tommaso; Marinelli, Mattia

    2014-01-01

    This paper presents an innovative control scheme for the management of energy consumption in commercial build- ings with local energy production, such as photovoltaic panels or wind turbine and an energy storage unit. The presented scheme is based on distributed model predictive controllers, which...... manage the storage system and the building space heating and cooling. The proposed approach is implemented and tested in SYSLAB, the experimental facility for distributed energy systems at the Techni- cal University of Denmark, Risø Campus. The experimental setup consists of wind and solar renewable...

  1. Experimental Validation of Energy Resources Integration in Microgrids via Distributed Predictive Control

    DEFF Research Database (Denmark)

    Mantovani, Giancarlo; Costanzo, Giuseppe Tommaso; Marinelli, Mattia

    2014-01-01

    manage the storage system and the building space heating and cooling. The proposed approach is implemented and tested in SYSLAB, the experimental facility for distributed energy systems at the Techni- cal University of Denmark, Risø Campus. The experimental setup consists of wind and solar renewable...... sources, a vanadium redox battery system, resistive load, and a point of common coupling to the national grid. Several experiments are carried to assess the performance of the control scheme in managing local energy pro- duction and consumption....

  2. Case study for experimental validation of a new presizing tool for solar heating, cooling and domestic hot water closed systems

    Directory of Open Access Journals (Sweden)

    Hamza Semmari

    2017-09-01

    Full Text Available This paper presents a case study experimental validation of PISTACHE which is a new presizing tool intended for designers and planners. It facilitates pre-design and allows the evaluation of annual performance and the integration potential of solar heating, cooling and domestic hot water closed systems. This new tool has been performed in order to standardize the sizing methodology and the comparison of the SHC&DHW closed systems. The comparison framework used in PISTACHE has been performed using seasonal performance indicators that were issued and gathered from experimental data provided by several operating plants. Thus, PISTACHE is an easy graphical user interface and free downloadable tool. In order to check the reliability of the new developed tool, two configuration modes are investigated in this experimental study: a simple cooling mode (RAFSOL plant and a double cooling and heating mode (SONNENKRAFT installation. The whole validation process is performed using the GenOpt optimization program to determine the optimum set of internal parameters for PISTACHE tool.

  3. Experimental methods to validate measures of emotional state and readiness for duty in critical operations.

    Energy Technology Data Exchange (ETDEWEB)

    Weston, Louise Marie

    2007-09-01

    A recent report on criticality accidents in nuclear facilities indicates that human error played a major role in a significant number of incidents with serious consequences and that some of these human errors may be related to the emotional state of the individual. A pre-shift test to detect a deleterious emotional state could reduce the occurrence of such errors in critical operations. The effectiveness of pre-shift testing is a challenge because of the need to gather predictive data in a relatively short test period and the potential occurrence of learning effects due to a requirement for frequent testing. This report reviews the different types of reliability and validity methods and testing and statistical analysis procedures to validate measures of emotional state. The ultimate value of a validation study depends upon the percentage of human errors in critical operations that are due to the emotional state of the individual. A review of the literature to identify the most promising predictors of emotional state for this application is highly recommended.

  4. Validation of Geant4 on Proton Transportation for Thick Absorbers: Study Based on Tschalär Experimental Data

    Science.gov (United States)

    Hoff, Gabriela; Denyak, Valeriy; Schelin, Hugo R.; Paschuk, Sergei

    2017-02-01

    Imaging techniques using protons as incident particles are currently being developed to substitute X-ray computer tomography and nuclear magnetic resonance methods in proton therapy. They deal with relatively thick targets, like the human head or trunk, where protons lose a significant part of their energy, however, they have enough energy to exit the target. The physical quantities important in proton imaging are kinetic energy, angle and coordinates of emerging proton from an absorber material. In recent times, many research groups use the Geant4 toolkit to simulate proton imaging devices. Most of the available publications about validation of Geant4 models are for thin or thick absorbers (Bragg Peak studies), that are not consistent with the contour conditions applied to proton imaging. The main objective of this work is to evaluate the kinetic energy spectrum for protons emerging from homogeneous absorbers slabs comparing it to the experimental results published by Tschalär and Maccabee, in 1970. Different models (standard and detailed) available on Geant4 (version 9.6.p03) are explored taking into account its accuracy and computational performance. This paper presents a validation for protons with incident kinetic energies of 19.68 MeV and 49.10 MeV. The validation results from the emerging protons kinetic energy spectra show that: (i) there are differences between the reference data and the data produced by different processes evoked for transportation and (ii) the validation energies are sensitive to sub-shell processes.

  5. Pattern dynamics of vortex ripples in sand: Nonlinear modeling and experimental validation

    DEFF Research Database (Denmark)

    Andersen, Ken Haste; Abel, M.; Krug, J.

    2002-01-01

    Vortex ripples in sand are studied experimentally in a one-dimensional setup with periodic boundary conditions. The nonlinear evolution, far from the onset of instability, is analyzed in the framework of a simple model developed for homogeneous patterns. The interaction function describing the ma...

  6. An experimentally validated fatigue model for wood subjected to tension perpendicular to the grain

    DEFF Research Database (Denmark)

    Clorius, Christian Odin; Pedersen, Martin Uhre; Hoffmeyer, Preben

    2009-01-01

    This study presents an experimental investigation of fatigue in wood subjected to tension perpendicular to the grain. The study has been designed with special reference to the influence of the frequency of loading. The investigation reveals an interaction between number of load oscillations...

  7. Experimental benchmark and code validation for airfoils equipped with passive vortex generators

    NARCIS (Netherlands)

    Baldacchino, D.; Manolesos, M.; Simao Ferreira, C.; Gonz?alez Salcedo, A; Aparicio, M.; Chaviaropoulos, T.; Diakakis, K.; Florentie, L.; Garci??a, M.; Papadakis, G; So?rensen, N.N.; Timmer, W.A.; Troldborg, N.; Voutsinas, S.; van Zuijlen, A.H.

    2016-01-01

    Experimental results and complimentary computations for airfoils with vortex generators are compared in this paper, as part of an e_ort within the AVATAR project to develop tools for wind turbine blade control devices. Measurements from two airfoils equipped with passive vortex generators, a 30%

  8. A Transverse Oscillation Approach for Estimation of Three-Dimensional Velocity Vectors, Part II: Experimental Validation

    DEFF Research Database (Denmark)

    Pihl, Michael Johannes; Stuart, Matthias Bo; Tomov, Borislav Gueorguiev

    2014-01-01

    The 3-D transverse oscillation method is investigated by estimating 3-D velocities in an experimental flowrigsystem. Measurements of the synthesized transverse oscillatingfields are presented as well. The method employs a 2-D transducer; decouples the velocity estimation; and estimates the axial,...

  9. Experimental performance evaluation and validation of dynamical models of the Ocean Grazer

    NARCIS (Netherlands)

    van Rooij, Marijn; Meijer, Harmen; Prins, Wouter; Vakis, Antonis I.

    2015-01-01

    A functional scale prototype has been constructed for a single-piston pump (SPP) that will be used as a building block in the core technology of a novel wave energy converter termed the Ocean Grazer: the multi-pump, multi-piston power take-off (MP2PTO) system. Experimental measurements performed

  10. Tracer experimental techniques for CFD model verification and validation in sugar crystallizer

    NARCIS (Netherlands)

    Griffith, J.; Borroto, J.; Dominguez, J.; Derivet, M.; Cuesta, J.; Flores, P.; Fernandez Rivas, David; Amor, A.; Franklin, B.

    2004-01-01

    In the framework of the CRP improvement of the experimental design for RTD tests at a pilot crystallizer was performed. A new approach for RTD studies in non-Newtonian fluids for flow patterns characterization at the pilot crystallizer was carried out. Batch mixing process was tested and the

  11. PSpice Modeling Platform for SiC Power MOSFET Modules with Extensive Experimental Validation

    DEFF Research Database (Denmark)

    Ceccarelli, Lorenzo; Iannuzzo, Francesco; Nawaz, Muhammad

    2016-01-01

    The aim of this work is to present a PSpice implementation for a well-established and compact physics-based SiC MOSFET model, including a fast, experimental-based parameter extraction procedure in a MATLAB GUI environment. The model, originally meant for single-die devices, has been used...

  12. Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols.

    Science.gov (United States)

    Carro, Jesús; Rodríguez-Matas, José F; Monasterio, Violeta; Pueyo, Esther

    2017-10-01

    Models of ion channel dynamics are usually built by fitting isolated cell experimental values of individual parameters while neglecting the interaction between them. Another shortcoming regards the estimation of ionic current conductances, which is often based on quantification of Action Potential (AP)-derived markers. Although this procedure reduces the uncertainty in the calculation of conductances, many studies evaluate electrophysiological AP-derived markers from single cell simulations, whereas experimental measurements are obtained from tissue preparations. In this work, we explore the limitations of these approaches to estimate ion channel dynamics and maximum current conductances and how they could be overcome by using multiscale simulations of experimental protocols. Four human ventricular cell models, namely ten Tusscher and Panfilov (2006), Grandi et al. (2010), O'Hara et al. (2011), and Carro et al. (2011), were used. Two problems involving scales from ion channels to tissue were investigated: 1) characterization of L-type calcium voltage-dependent inactivation ICa,L; 2) identification of major ionic conductance contributors to steady-state AP markers, including APD90, APD75, APD50, APD25, Triangulation and maximal and minimal values of V and dV/dt during the AP (Vmax, Vmin, dV/dtmax, dV/dtmin). Our results show that: 1) ICa,L inactivation characteristics differed significantly when calculated from model equations and from simulations reproducing the experimental protocols. 2) Large differences were found in the ionic currents contributors to APD25, Triangulation, Vmax, dV/dtmax and dV/dtmin between single cells and 1D-tissue. When proposing any new model formulation, or evaluating an existing model, consistency between simulated and experimental data should be verified considering all involved effects and scales. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Experimental Validation of Modelled Fluid Forces in Fast Switching Hydraulic On/Off Valves

    DEFF Research Database (Denmark)

    Nørgård, Christian; Bech, Michael Møller; Roemer, Daniel Beck

    2015-01-01

    A prototype of a fast switching valve for a digital hydraulic machine has been designed and manufactured. The valve is composed of an annular seat plunger connected with a moving coil actuator as the force producing element. The valve prototype is designed for flow rates of 600 l/min with less than...... approaches the closed position. Fast switching is essential for digital hydraulic machines to achieve a high efficiency. As the fluid forces influences the response obtaining an accurate model is important. To validate the model tests are carried out on the prototype where the valve is closed, both...

  14. Validation of Experimental whole-body SAR Assessment Method in a Complex Indoor Environment

    DEFF Research Database (Denmark)

    Bamba, Aliou; Joseph, Wout; Vermeeren, Gunter

    2012-01-01

    simulations with the Finite-Difference Time-Domain method. Furthermore, the method accounts for the diffuse multipath components (DMC) in the total absorption rate by considering the reverberation time of the investigated room, which describes all the losses in a complex indoor environment. The advantage...... of the proposed method is that it allows discarding the computation burden because it does not use any discretizations. Results show good agreement between measurement and computation at 2.8 GHz, as long as the plane wave assumption is valid, i.e., for high distances from the transmitter. Relative deviations 0...

  15. Environmental dose rate heterogeneity of beta radiation and its implications for luminescence dating: Monte Carlo modelling and experimental validation

    DEFF Research Database (Denmark)

    Nathan, R.P.; Thomas, P.J.; Jain, M.

    2003-01-01

    The recent development of rapid single sand-sized grain analyses in luminescence dating has necessitated the accurate interpretation of D-e distributions to recover a representative D-e acquired since the last bleaching event. Beta heterogeneity may adversely affect the variance and symmetry of D...... and identify the likely size of these effects on D-e distributions. The study employs the MCNP 4C Monte Carlo electron/photon transport model, supported by an experimental validation of the code in several case studies. We find good agreement between the experimental measurements and the Monte Carlo......-e distributions and it is important to characterise this effect, both to ensure that dose distributions are not misinterpreted, and that an accurate beta dose rate is employed in dating calculations. In this study, we make a first attempt providing a description of potential problems in heterogeneous environments...

  16. Numerical Validation of a Vortex Model against ExperimentalData on a Straight-Bladed Vertical Axis Wind Turbine

    Directory of Open Access Journals (Sweden)

    Eduard Dyachuk

    2015-10-01

    Full Text Available Cyclic blade motion during operation of vertical axis wind turbines (VAWTs imposes challenges on the simulations models of the aerodynamics of VAWTs. A two-dimensional vortex model is validated against the new experimental data on a 12-kW straight-bladed VAWT, which is operated at an open site. The results on the normal force on one blade are analyzed. The model is assessed against the measured data in the wide range of tip speed ratios: from 1.8 to 4.6. The predicted results within one revolution have a similar shape and magnitude as the measured data, though the model does not reproduce every detail of the experimental data. The present model can be used when dimensioning the turbine for maximum loads.

  17. Experimental Validation of the Sensitivity of Waveguide Grating Based Refractometric (Bio)sensors

    Science.gov (United States)

    Gartmann, Thomas E.; Kehl, Florian

    2015-01-01

    Despite the fact that the theoretical foundations of the sensitivity of waveguide grating based (bio)sensors are well-known, understood and their implications anticipated by the scientific community since several decades, to our knowledge, no prior publication has experimentally confirmed waveguide sensitivity for multiple film thicknesses, wavelengths and polarization of the propagating light. In this paper, the bulk refractive index sensitivity versus waveguide thickness of said refractometric sensors is experimentally determined and compared with predictions based on established theory. The effective refractive indices and the corresponding sensitivity were determined via the sensors’ coupling angles at different cover refractive indices for transverse electric as well as transverse magnetic polarized illumination at various wavelengths in the visible and near-infrared. The theoretical sensitivity was calculated by solving the mode equation for a three layer waveguide. PMID:25871832

  18. Experimental Validation of Mathematical Framework for Fast Switching Valves used in Digital Hydraulic Machines

    DEFF Research Database (Denmark)

    Nørgård, Christian; Roemer, Daniel Beck; Bech, Michael Møller

    2015-01-01

    A prototype of a fast switching valve designed for a digital hydraulic transmission has been manufactured and experimentally tested. The valve is an annular seat valve composed of a plunger connected with a direct electromagnetic moving coil actuator as the force producing element. Based on an el......A prototype of a fast switching valve designed for a digital hydraulic transmission has been manufactured and experimentally tested. The valve is an annular seat valve composed of a plunger connected with a direct electromagnetic moving coil actuator as the force producing element. Based...... on an elaborate optimization method the valve is designed to maximize the efficiency of a digital hydraulic motor targeted to a wind turbine transmission system. The optimisation method comprises a mathematical framework which predicts a valve switching time of approximately 1 ms with a peak actuator input power...

  19. Experimental benchmark and code validation for airfoils equipped with passive vortex generators

    Science.gov (United States)

    Baldacchino, D.; Manolesos, M.; Ferreira, C.; González Salcedo, Á.; Aparicio, M.; Chaviaropoulos, T.; Diakakis, K.; Florentie, L.; García, N. R.; Papadakis, G.; Sørensen, N. N.; Timmer, N.; Troldborg, N.; Voutsinas, S.; van Zuijlen, A.

    2016-09-01

    Experimental results and complimentary computations for airfoils with vortex generators are compared in this paper, as part of an effort within the AVATAR project to develop tools for wind turbine blade control devices. Measurements from two airfoils equipped with passive vortex generators, a 30% thick DU97W300 and an 18% thick NTUA T18 have been used for benchmarking several simulation tools. These tools span low-to-high complexity, ranging from engineering-level integral boundary layer tools to fully-resolved computational fluid dynamics codes. Results indicate that with appropriate calibration, engineering-type tools can capture the effects of vortex generators and outperform more complex tools. Fully resolved CFD comes at a much higher computational cost and does not necessarily capture the increased lift due to the VGs. However, in lieu of the limited experimental data available for calibration, high fidelity tools are still required for assessing the effect of vortex generators on airfoil performance.

  20. Experimental benchmark and code validation for airfoils equipped with passive vortex generators

    DEFF Research Database (Denmark)

    Baldacchino, D.; Manolesos, M.; Ferreira, Célia Maria Dias

    2016-01-01

    Experimental results and complimentary computations for airfoils with vortex generators are compared in this paper, as part of an effort within the AVATAR project to develop tools for wind turbine blade control devices. Measurements from two airfoils equipped with passive vortex generators, a 30......% thick DU97W300 and an 18% thick NTUA T18 have been used for benchmarking several simulation tools. These tools span low-to-high complexity, ranging from engineering-level integral boundary layer tools to fully-resolved computational fluid dynamics codes. Results indicate that with appropriate...... calibration, engineering-type tools can capture the effects of vortex generators and outperform more complex tools. Fully resolved CFD comes at a much higher computational cost and does not necessarily capture the increased lift due to the VGs. However, in lieu of the limited experimental data available...

  1. Experimental Validation of Methods for Prophylaxis against Deep Venous Thrombosis: A Review and Proposal

    Directory of Open Access Journals (Sweden)

    Paul S. Agutter

    2012-01-01

    Full Text Available The experimental procedure by which the valve cusp hypoxia (VCH hypothesis of the etiology of deep venous thrombosis (DVT was confirmed lends itself to testing of methods of prophylaxis. Similar animal experiments could end the present exclusive reliance on statistical analysis of data from large patient cohorts to evaluate prophylactic regimes. The reduction of need for such (usually retrospective analyses could enable rationally-based clinical trials of prophylactic methods to be conducted more rapidly, and the success of such trials would lead to decreased incidences of DVT-related mortality and morbidity. This paper reviews the VCH hypothesis (“VCH thesis”, following its corroboration and its implications for understanding DVT and its sequelae, and outlines the experimental protocol for testing prophylactic methods. The advantages and limitations of the protocol are briefly discussed.

  2. Modeling and experimental validation of hydrodynamics in an ultrasonic batch reactor.

    Science.gov (United States)

    Ajmal, M; Rusli, S; Fieg, G

    2016-01-01

    Simulation of hydrodynamics in ultrasonic batch reactor containing immobilized enzymes as catalyst is done. A transducer with variable power and constant frequency (24 kHz) is taken as source of ultrasound (US). Simulation comprises two steps. In first step, acoustic pressure field is simulated and in second step effect of this field on particle trajectories is simulated. Simulation results are compared with experimentally determined particle trajectories using PIV Lab (particle image velocimetry). Effect of varying ultrasonic power, positioning and number of ultrasonic sources on particle trajectories is studied. It is observed that catalyst particles tend to orientate according to pattern of acoustic pressure field. An increase in ultrasonic power increases particle velocity and also brings more particles into motion. Simulation results are found to be in agreement with experimentally determined data. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Simulation and experimental validation of a 400 m vertical CO2 heat pipe for geothermal application

    Science.gov (United States)

    Ebeling, Johann-Christoph; Kabelac, Stephan; Luckmann, Sebastian; Kruse, Horst

    2017-11-01

    Geothermal heat pipes are an effective heat source for heat pumps used for space heating. Because the area for the installation of borehole heat exchangers is limited in urban areas (one site per borehole), the maximum heat extractable from one borehole shall rise. In cooperation with the FKW Hannover, the Institute for Thermodynamics of the Leibniz University of Hannover is investigating the thermodynamic behavior of CO2 driven geothermal heat pipes of higher thermal power. Therefore two different types of geothermal heat pipes with a length of 400 m each have been installed. Furthermore a numerical simulation of the heat and mass transfer within the pipes is under development. The experimental setup and first results of the experiments are presented as well as the current status of the numerical simulation. A comparison of the two different types of heat pipes and a comparison of the experimental data with the numerical simulation is given.

  4. Error modelling and experimental validation of a planar 3-PPR parallel manipulator with joint clearances

    DEFF Research Database (Denmark)

    Wu, Guanglei; Bai, Shaoping; Kepler, Jørgen Asbøl

    2012-01-01

    This paper deals with the error modelling and analysis of a 3-PPR planar parallel manipulator with joint clearances. The kinematics and the Cartesian workspace of the manipulator are analyzed. An error model is established with considerations of both configuration errors and joint clearances. Using...... this model, the upper bounds and distributions of the pose errors for this manipulator are established. The results are compared with experimental measurements and show the effectiveness of the error prediction model....

  5. Advanced design and experimental validation of MRI contrast agents for fluid pressure mapping using microbubbles

    OpenAIRE

    Morris, RH

    2009-01-01

    This work is related to monitoring fluid pressure using Magnetic Resonance Imaging or MRI and includes numerical simulations and experimental MRI. The nature of this study is such that techniques other than MRI have been extensively used to assess the contrast agent for its physical behaviour. These techniques include rheometry, light scattering, optical and scanning electron microscopy. Six MRI experiments in total were performed: The first two experiments use standard spin echo imaging tech...

  6. New experimental data for validation of nanoparticle dry deposition velocity models

    Science.gov (United States)

    Damay, P. E.; Maro, D.; Coppalle, A.; Lamaud, E.; Connan, O.; Herbert, D.; Talbaut, M.; Irvine, M.

    2009-04-01

    In Order to evaluate the impact of the aerosol pollution on ecosystems, we have to study the transfer functions of particles on vegetated canopies. One of them is the dry deposition, which is defined by the deposition velocity (Vd): the ratio between particles surface flux and the atmospheric aerosol concentration nearby the surface. This deposition velocity depends on many parameters. For example, the topography ground, the substrate, the micrometeorological conditions (turbulence), the aerosol characteristics (size, electric charge) and external fields (gravity, electric). Nowadays, there are several models of aerosol dry deposition which consider the effects of the turbulence, the particles size for a large range of diameter (some nm to 100 µm). In the case of nanoparticles, there is not enough reliable experimental data to allow a comparison with the dry deposition models. For operative models, the scattering of Vd experimental data of nanoparticles in a rural environment creates uncertainties larger than one order of magnitude. The study of the aerosols dry deposition velocity has remained an international challenge since the sixties and involves an in situ experimental approach, in order to consider the local particularities (substrate, turbulence, vegetated canopies, etc…) The main aim of this study is to obtain experimental data on aerosol dry deposition velocities onto rural areas. Therefore we have developed a direct eddy covariance method. The use of an Electrical Low Pressure Impactor (Outdoor ELPI, Dekati Inc.) for this method enables to calculate dry deposition velocities for atmospheric aerosols sizing from 7 nm to 2 µm. We present our results: discuss the impact of micrometeorological parameters and particle size on the dry deposition velocity and the possibility to apply this method on other environments.

  7. Experimental Design and Validation of an Accelerated Random Vibration Fatigue Testing Methodology

    OpenAIRE

    Yu Jiang(Center for Statistical and Theoretical Condensed Matter Physics, Zhejiang Normal University, Jinhua City, Zhejiang Province 321004, China); Gun Jin Yun; Li Zhao; Junyong Tao

    2015-01-01

    Novel accelerated random vibration fatigue test methodology and strategy are proposed, which can generate a design of the experimental test plan significantly reducing the test time and the sample size. Based on theoretical analysis and fatigue damage model, several groups of random vibration fatigue tests were designed and conducted with the aim of investigating effects of both Gaussian and non-Gaussian random excitation on the vibration fatigue. First, stress responses at a weak point of a ...

  8. Computational prediction and experimental validation of Ciona intestinalis microRNA genes

    Directory of Open Access Journals (Sweden)

    Pasquinelli Amy E

    2007-11-01

    Full Text Available Abstract Background This study reports the first collection of validated microRNA genes in the sea squirt, Ciona intestinalis. MicroRNAs are processed from hairpin precursors to ~22 nucleotide RNAs that base pair to target mRNAs and inhibit expression. As a member of the subphylum Urochordata (Tunicata whose larval form has a notochord, the sea squirt is situated at the emergence of vertebrates, and therefore may provide information about the evolution of molecular regulators of early development. Results In this study, computational methods were used to predict 14 microRNA gene families in Ciona intestinalis. The microRNA prediction algorithm utilizes configurable microRNA sequence conservation and stem-loop specificity parameters, grouping by miRNA family, and phylogenetic conservation to the related species, Ciona savignyi. The expression for 8, out of 9 attempted, of the putative microRNAs in the adult tissue of Ciona intestinalis was validated by Northern blot analyses. Additionally, a target prediction algorithm was implemented, which identified a high confidence list of 240 potential target genes. Over half of the predicted targets can be grouped into the gene ontology categories of metabolism, transport, regulation of transcription, and cell signaling. Conclusion The computational techniques implemented in this study can be applied to other organisms and serve to increase the understanding of the origins of non-coding RNAs, embryological and cellular developmental pathways, and the mechanisms for microRNA-controlled gene regulatory networks.

  9. Validation of the AeroDyn subroutines using NREL unsteady aerodynamics experimental data

    Energy Technology Data Exchange (ETDEWEB)

    Laino, D.J.; Hansen, A.C.; Minnema, J.E. [Windward Engineering, Salt Lake City, UT (United States)

    2002-07-01

    Completion of the full-scale wind tunnel tests of the NREL Unsteady Aerodynamics Experiment (UAE) phase VI allowed validation of the AeroDyn wind turbine aerodynamics software to commence. Detailed knowledge of the inflow to the UAE was the bane of prior attempts to accomplish any in-depth validation in the past. The wind tunnel tests permitted unprecedented control and measurement of inflow to the UAE rotor. The data collected from these UAE tests are currently under investigation as part of an effort to better understand wind turbine rotor aerodynamics in order to improve aeroelastic modelling techniques. Preliminary results from this study using the AeroDyn subroutines are presented, pointing to several avenues towards improvement. Test data indicate that rotational effects cause more static stall delay over a larger portion of the blades than predicted by current methods. Despite the relatively stiff properties of the UAE, vibration modes appear to influence the aerodynamic forces and system loads. AeroDyn adequately predicts dynamic stall hysteresis loops when appropriate steady, 2D aerofoil tables are used. Problems encountered include uncertainties in converting measured inflow angle to angle of attack for the UAE phase VI. Future work is proposed to address this angle-of-attack problem and to analyse a slightly more complex dynamics model that incorporates some of the structural vibration modes evident in the test data. (author)

  10. A predictive bone drilling force model for haptic rendering with experimental validation using fresh cadaveric bone.

    Science.gov (United States)

    Lin, Yanping; Chen, Huajiang; Yu, Dedong; Zhang, Ying; Yuan, Wen

    2017-01-01

    Bone drilling simulators with virtual and haptic feedback provide a safe, cost-effective and repeatable alternative to traditional surgical training methods. To develop such a simulator, accurate haptic rendering based on a force model is required to feedback bone drilling forces based on user input. Current predictive bone drilling force models based on bovine bones with various drilling conditions and parameters are not representative of the bone drilling process in bone surgery. The objective of this study was to provide a bone drilling force model for haptic rendering based on calibration and validation experiments in fresh cadaveric bones with different bone densities. Using a commonly used drill bit geometry (2 mm diameter), feed rates (20-60 mm/min) and spindle speeds (4000-6000 rpm) in orthognathic surgeries, the bone drilling forces of specimens from two groups were measured and the calibration coefficients of the specific normal and frictional pressures were determined. The comparison of the predicted forces and the measured forces from validation experiments with a large range of feed rates and spindle speeds demonstrates that the proposed bone drilling forces can predict the trends and average forces well. The presented bone drilling force model can be used for haptic rendering in surgical simulators.

  11. A method for landing gear modeling and simulation with experimental validation

    Science.gov (United States)

    Daniels, James N.

    1996-01-01

    This document presents an approach for modeling and simulating landing gear systems. Specifically, a nonlinear model of an A-6 Intruder Main Gear is developed, simulated, and validated against static and dynamic test data. This model includes nonlinear effects such as a polytropic gas model, velocity squared damping, a geometry governed model for the discharge coefficients, stick-slip friction effects and a nonlinear tire spring and damping model. An Adams-Moulton predictor corrector was used to integrate the equations of motion until a discontinuity caused by a stick-slip friction model was reached, at which point, a Runga-Kutta routine integrated past the discontinuity and returned the problem solution back to the predictor corrector. Run times of this software are around 2 mins. per 1 sec. of simulation under dynamic circumstances. To validate the model, engineers at the Aircraft Landing Dynamics facilities at NASA Langley Research Center installed one A-6 main gear on a drop carriage and used a hydraulic shaker table to provide simulated runway inputs to the gear. Model parameters were tuned to produce excellent agreement for many cases.

  12. Vygotsky on Education Primer. Peter Lang Primer. Volume 30

    Science.gov (United States)

    Lake, Robert

    2012-01-01

    The "Vygotsky on Education Primer" serves as an introduction to the life and work of the Russian psychologist Lev Vygotsky. Even though he died almost eighty years ago, his life's work remains both relevant and significant to the field of education today. This book examines Vygotsky's emphasis on the role of cultural and historical context in…

  13. Design and Experimental Validation of a USBL Underwater Acoustic Positioning System

    Directory of Open Access Journals (Sweden)

    Joel Reis

    2016-09-01

    Full Text Available This paper presents the steps for developing a low-cost POrtableNavigation Tool for Underwater Scenarios (PONTUS to be used as a localization device for subsea targets. PONTUS consists of an integrated ultra-short baseline acoustic positioning system aided by an inertial navigation system. Built on a practical design, it can be mounted on an underwater robotic vehicle or be operated by a scuba diver. It also features a graphical user interface that provides information on the tracking of the designated target, in addition to some details on the physical properties inside PONTUS. A full disclosure of the architecture of the tool is first presented, followed by thorough technical descriptions of the hardware components ensemble and the software development process. A series of experiments was carried out to validate the developed prototype, and the results are presented herein, which allow assessing its overall performance.

  14. A Strong Validation of the Crosswise Model Using Experimentally-Induced Cheating Behavior.

    Science.gov (United States)

    Hoffmann, Adrian; Diedenhofen, Birk; Verschuere, Bruno; Musch, Jochen

    2015-01-01

    We constructed an online cheating paradigm that could be used to validate the Crosswise Model ( Yu, Tian, & Tang, 2008 ), a promising indirect questioning technique designed to control for socially desirable responding on sensitive questions. Participants qualified for a reward only if they could identify the target words from three anagrams, one of which was virtually unsolvable as shown on a pretest. Of the 664 participants, 15.5% overreported their performance and were categorized as cheaters. When participants were asked to report whether they had cheated, a conventional direct question resulted in a substantial underestimate (5.1%) of the known prevalence of cheaters. Using a CWM question resulted in a more accurate estimate (13.0%). This result shows that the CWM can be used to control for socially desirable responding and provides estimates that are much closer to the known prevalence of a sensitive personal attribute than those obtained using a direct question.

  15. EVALUATION OF FLOW DISTRIBUTION IN THE PELLETIZING FURNACE THROUGH CFD AND EXPERIMENTAL VALIDATION AT SAMARCO

    Directory of Open Access Journals (Sweden)

    Maycon Athayde

    2014-12-01

    Full Text Available Samarco produces iron ore pellets thermally processed in Travelling Grate furnaces. This process is essential in order to obtain adequate mechanical strength to the pellets transportation and operation in the reduction reactors. All the mechanical properties of the agglomerates are obtained during the stage of firing, being a decisive step to pellet quality. Therefore, the velocity distribution of gas flow within this zone must be homogeneous. For this reason, it was developed a mathematical CFD model to characterize the gas flow in the burning zone, applying the equations of conservation of momentum, mass and energy. The validation of the model was obtained by measuring the temperatures inside the furnace. It was developed a wireless communication system in order to monitor continuously the evolution of the temperatures in the furnace.

  16. Computational Design of Creep-Resistant Alloys and Experimental Validation in Ferritic Superalloys

    Energy Technology Data Exchange (ETDEWEB)

    Liaw, Peter

    2014-12-31

    A new class of ferritic superalloys containing B2-type zones inside parent L21-type precipitates in a disordered solid-solution matrix, also known as a hierarchical-precipitate strengthened ferritic alloy (HPSFA), has been developed for high-temperature structural applications in fossil-energy power plants. These alloys were designed by the addition of the Ti element into a previously-studied NiAl-strengthened ferritic alloy (denoted as FBB8 in this study). In the present research, systematic investigations, including advanced experimental techniques, first-principles calculations, and numerical simulations, have been integrated and conducted to characterize the complex microstructures and excellent creep resistance of HPSFAs. The experimental techniques include transmission-electron microscopy, scanningtransmission- electron microscopy, neutron diffraction, and atom-probe tomography, which provide detailed microstructural information of HPSFAs. Systematic tension/compression creep tests revealed that HPSFAs exhibit the superior creep resistance, compared with the FBB8 and conventional ferritic steels (i.e., the creep rates of HPSFAs are about 4 orders of magnitude slower than the FBB8 and conventional ferritic steels.) First-principles calculations include interfacial free energies, anti-phase boundary (APB) free energies, elastic constants, and impurity diffusivities in Fe. Combined with kinetic Monte- Carlo simulations of interdiffusion coefficients, and the integration of computational thermodynamics and kinetics, these calculations provide great understanding of thermodynamic and mechanical properties of HPSFAs. In addition to the systematic experimental approach and first-principles calculations, a series of numerical tools and algorithms, which assist in the optimization of creep properties of ferritic superalloys, are utilized and developed. These numerical simulation results are compared with the available experimental data and previous first

  17. Experimental Characterization and Validation of Simultaneous Gust Alleviation and Energy Harvesting for Multifunctional Wing Spars

    Science.gov (United States)

    2012-08-01

    PCB Clamp QP10 n Composite Sandwich Accelerometer MFC Experimental   CharacterizaBon  of   TransducBon  AbiliBes   4/36...dSPACE Board PC w/Simulink/ Control Desk Laser Sensor Accelerometer Current Meter Shaker PCB Clamp QP10n Composite Sandwich Acceleromete r Which...is  the  best   transducer?   What  is  the   coupling   coefficient?   What  is  the   internal   capacitance

  18. Tailored Solutions to Problems Resolution - An Experimental Validation of a Cognitive Computational Knowledge Representation Model

    Directory of Open Access Journals (Sweden)

    Mehdi Najjar

    2007-02-01

    Full Text Available In spite of an increasing development of virtual and distant applications which use the advantages of multimedia and the Internet for distance education, learning by means of such tutorial tools would be more effective if they were specifically adapted to each user needs. This paper proposes a knowledge representation model which judiciously serves the remediation process of an intelligent learning environment in interaction with students during virtual learning activities. By means of experimental results obtained thanks to practical tests, we show that our knowledge representation model facilitates the planning of a tailored sequence of feedbacks that significantly help the learner.

  19. Design of Passive Acoustic Wave Shaping Devices and Their Experimental Validation

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Sigmund, Ole; Fernandez Grande, Efren

    We discuss a topology optimization based approach for designing passive acoustic wave shaping devices and demonstrate its application to; directional sound emission [1], sound focusing and wave splitting. Optimized devices, numerical and experimental results are presented and benchmarked against...... by the Helmholtz equation. An exterior 2D model domain is used and an array of point sources is considered as sound emitters. The optimization goal is to identify a distribution of solid material in a design sub-domain which produces a desired spatial sound feld pattern across a frequency band of interest...

  20. N2C2M2 Experimentation and Validation: Understanding Its C2 Approaches and Implications

    Science.gov (United States)

    2010-06-01

    the organization and execution of the experiments, specifically, Col. Fernando Freire , LtCol. António Flambó, LtCol. José Martins, LtCol. Paulo ...of ELICIT Experimental Data. Paper presented at the 13th ICCRTS, Seattle, USA, 2008. [13.] Manso, Marco, and Paulo Nunes. ELICIT and the Future C2...detailed mapping between C2 CRM variables and ELICIT refer to: MANSO, Marco, and Paulo NUNES. ELICIT and the Future C2: Theoretical Foundations for the

  1. High-Area-Ratio Rocket Nozzle at High Combustion Chamber Pressure: Experimental and Analytical Validation

    Science.gov (United States)

    Jankovsky, Robert S.; Smith, Timothy D.; Pavli, Albert J.

    1999-01-01

    Experimental data were obtained on an optimally contoured nozzle with an area ratio of 1025:1 and on a truncated version of this nozzle with an area ratio of 440:1. The nozzles were tested with gaseous hydrogen and liquid oxygen propellants at combustion chamber pressures of 1800 to 2400 psia and mixture ratios of 3.89 to 6.15. This report compares the experimental performance, heat transfer, and boundary layer total pressure measurements with theoretical predictions of the current Joint Army, Navy, NASA, Air Force (JANNAF) developed methodology. This methodology makes use of the Two-Dimensional Kinetics (TDK) nozzle performance code. Comparisons of the TDK-predicted performance to experimentally attained thrust performance indicated that both the vacuum thrust coefficient and the vacuum specific impulse values were approximately 2.0-percent higher than the turbulent prediction for the 1025:1 configurations, and approximately 0.25-percent higher than the turbulent prediction for the 440:1 configuration. Nozzle wall temperatures were measured on the outside of a thin-walled heat sink nozzle during the test fittings. Nozzle heat fluxes were calculated front the time histories of these temperatures and compared with predictions made with the TDK code. The heat flux values were overpredicted for all cases. The results range from nearly 100 percent at an area ratio of 50 to only approximately 3 percent at an area ratio of 975. Values of the integral of the heat flux as a function of nozzle surface area were also calculated. Comparisons of the experiment with analyses of the heat flux and the heat rate per axial length also show that the experimental values were lower than the predicted value. Three boundary layer rakes mounted on the nozzle exit were used for boundary layer measurements. This arrangement allowed total pressure measurements to be obtained at 14 different distances from the nozzle wall. A comparison of boundary layer total pressure profiles and analytical

  2. Experimental Validation of BDI Agents for Distributed Control of Electric Power Grids

    DEFF Research Database (Denmark)

    Issicaba, Diego; Rosa, Mauro A.; Prostejovsky, Alexander Maria

    2017-01-01

    , respectively. Belief-desire-intention reasoning is achieved through JASON’s engine while artifacts monitor and control grid devices using dedicated JAVA objects. Experiments have been conducted in SYSLAB, a testbed for distributed power system control and distributed solutions, located at the Risø campus...... of the Technical University of Denmark. Experimental results show the feasibility of applying belief-desire-intention reasoning to WoC control using a test case where tie-line power flow setpoints must be followed...

  3. ANN Approach for State Estimation of Hybrid Systems and Its Experimental Validation

    Directory of Open Access Journals (Sweden)

    Shijoh Vellayikot

    2015-01-01

    Full Text Available A novel artificial neural network based state estimator has been proposed to ensure the robustness in the state estimation of autonomous switching hybrid systems under various uncertainties. Taking the autonomous switching three-tank system as benchmark hybrid model working under various additive and multiplicative uncertainties such as process noise, measurement error, process–model parameter variation, initial state mismatch, and hand valve faults, real-time performance evaluation by the comparison of it with other state estimators such as extended Kalman filter and unscented Kalman Filter was carried out. The experimental results reported with the proposed approach show considerable improvement in the robustness in performance under the considered uncertainties.

  4. Management of Power Quality Issues in Low Voltage Networks using Electric Vehicles: Experimental Validation

    DEFF Research Database (Denmark)

    Martinenas, Sergejus; Knezovic, Katarina; Marinelli, Mattia

    2017-01-01

    the existing and future power quality problems. One of the main aspects of the power quality relates to voltage quality. The aim of this work is to experimentally analyse whether series-produced EVs, adhering to contemporary standard and without relying on any V2G capability, can mitigate line voltage drops...... in improving the power quality of a highly unbalanced grid......As Electric Vehicles (EVs) are becoming more wide spread, their high power consumption presents challenges for the residential low voltage networks, especially when connected to long feeders with unevenly distributed loads. However, if intelligently integrated, EVs can also partially solve...

  5. New experimental validation of the pulse height weighting technique for capture cross-section measurements

    Energy Technology Data Exchange (ETDEWEB)

    Abbondanno, U.; Aerts, G.; Alvarez, H.; Andriamonje, S.; Angelopoulos, A.; Assimakopoulos, P.; Bacri, C.O.; Badurek, G.; Baumann, P.; Becvar, F.; Beer, H.; Benlliure, J.; Berthier, B.; Berthomieux, E.; Boffi, S.; Borcea, C.; Boscolo-Marchi, E.; Bustreo, N.; Calvino, P.; Cano-Ott, D.; Capote, R.; Carlson, P.; Cennini, P.; Chepel, V.; Chiaveri, E.; Coceva, C.; Colonna, N.; Cortes, G.; Cortina, D.; Couture, A.; Cox, J.; Dababneh, S.; Dahlfors, M.; David, S.; Dolfini, R.; Domingo-Pardo, C.; Duran, I.; Eleftheriadis, C.; Embid-Segura, M.; Ferrant, L.; Ferrari, A.; Ferreira-Lourenco, L.; Ferreira-Marques, R.; Frais-Koelbl, H.; Furman, W.I.; Giomataris, Y.; Goncalves, I.F.; Gonzalez-Romero, E.; Goverdovski, A.; Gramegna, F.; Griesmayer, E.; Gunsing, F.; Haight, R.; Heil, M.; Herrera-Martinez, A.; Ioannides, K.G.; Janeva, N.; Jericha, E.; Kaeppeler, F.; Kadi, Y.; Karamanis, D.; Kelic, A.; Ketlerov, V.; Kitis, G.; Koehler, P.E.; Konovalov, V.; Kossionides, E.; Lacoste, V.; Leeb, H.; Lindote, A.; Lopes, M.I.; Lozano, M.; Lukic, S.; Markov, S.; Marrone, S.; Martinez-Val, J.; Mastinu, P.; Mengoni, A.; Milazzo, P.M.; Minguez, E.; Molina-Coballes, A.; Moreau, C.; Neves, F.; Oberhummer, H.; O' Brien, S.; Pancin, J.; Papaevangelou, T.; Paradela, C.; Pavlik, A.; Pavlopoulos, P.; Perez-Parra, A.; Perlado, J.M.; Perrot, L.; Peskov, V.; Plag, R.; Plompen, A.; Plukis, A.; Poch, A.; Policarpo, A.; Pretel, C.; Quesada, J.M.; Radici, M.; Raman, S.; Rapp, W.; Rauscher, T.; Reifarth, R.; Rejmund, F.; Rosetti, M.; Rubbia, C.; Rudolf, G.; Rullhusen, P.; Salgado, J.; Savvidis, E.; Soares, J.C.; Stephan, C.; Tagliente, G.; Tain, J.L. E-mail: jose.luis.tain@ific.uv.es; Tapia, C.; Tassan-Got, L.; Tavora, L.M.N.; Terlizzi, R.; Terrani, M.; Tsangas, N.; Vannini, G.; Vaz, P.; Ventura, A.; Villamarin-Fernandez, D.; Vincente-Vincente, M.; Vlachoudis, V.; Vlastou, R.; Voss, F.; Wendler, H.; Wiescher, M.; Wisshak, K.; Zanini, L

    2004-04-01

    The accuracy of the pulse height weighting technique for the determination of neutron capture cross-sections is investigated. The technique is applied to measurements performed with C{sub 6}D{sub 6} liquid scintillation detectors of two different types using capture samples of various dimensions. The data for well-known (n,{gamma}) resonances are analyzed using weighting functions obtained from Monte Carlo simulations of the experimental set-up. Several causes of systematic deviation are identified and their effect is quantified. In all the cases measured the reaction yield agrees with the standard value within 2%.

  6. Theoretic model of myocardial revascularization by far infrared laser and experimental validation

    Science.gov (United States)

    Luo, Le; Chen, Xing; Zhang, Ting; Zong, Ren-He; Deng, Shan-Xi

    2009-03-01

    A theoretic model of myocardial revascularization by a far infrared laser has been established and a quantificational relationship between the aperture of laser channel and parameters of laser has been concluded according to thermodynamics and the law of interaction of far infrared laser and myocardium. The experiment of a carbon dioxide laser revascularization in porcine myocardium has been done for different laser powers and irradiation time. The relative errors between experimental result and theoretic computation are from 13% to 22%. The reasons that cause the errors have been studied in detail.

  7. Dynamic simulation and experimental validation of a two-phase closed thermosyphon for geothermal application

    Directory of Open Access Journals (Sweden)

    Johann-Christoph Ebeling

    2017-06-01

    Full Text Available The heat transfer performance of a vertical two-phase closed thermosyphon (TPCT used in a geothermal heat pump was experimentally investigated. The TPCT is a vertical plain steel pipe with inner diameter of 114 mm and bored 368 m deep underground. Carbon dioxide (CO2 is used as working fluid. In the TPCT there is no condensation section. CO2 is condensed by the evaporator of the heat pump, flows into the head of the TPCT and runs down as a falling film along the inner wall of the pipe. For the heat transfer simulation in the TPCT, a quasi-dynamic model in which the mass transfer between the liquid and vapor phases as well as the conduction heat transfer from the surrounding soil towards the pipe is treated dynamically. However the film flow modeling is based on the Nusselt theory of film condensation. The comparison of the experimental data with the numerical simulation is presented and discussed.

  8. JANNUS: A multi-irradiation platform for experimental validation at the scale of the atomistic modelling

    Science.gov (United States)

    Serruys, Y.; Trocellier, P.; Miro, S.; Bordas, E.; Ruault, M. O.; Kaïtasov, O.; Henry, S.; Leseigneur, O.; Bonnaillie, Th.; Pellegrino, S.; Vaubaillon, S.; Uriot, D.

    2009-04-01

    The Joint Accelerators for Nanosciences and NUclear Simulation project was started in 2002 in the frame of collaboration between CEA and CNRS. Due to the scientific skills developed for a long time, two experimental sites have been considered: (1) at Saclay, three electrostatic accelerators are being coupled, a new 3 MV Pelletron machine equipped with a multi-charged ion source, a 2.5 MV single ended Van de Graaff and a 2.25 MV tandem and (2) at Orsay, a 2 MV tandem and a 190 kV ion implanter are being coupled together with a 200 kV transmission electron microscope to allow simultaneous co-irradiation and observation. A brief review is first presented on multi-irradiation facilities available in the world. Then, a technical description of the new experimental facilities being installed is given. The main experiments we intend to carry out using mono, dual or triple irradiation configurations in different nuclear application fields and especially in the fusion domain will be further presented.

  9. Thermal-mechanical modeling and experimental validation of weld solidification cracking in 6061-T6 aluminum

    Energy Technology Data Exchange (ETDEWEB)

    Dike, J.J.; Brooks, J.A.; Bammann, D.J.; Li, M.

    1997-12-31

    Finite element simulation using an internal state variable constitutive model coupled with a void growth and damage model are used to study weld solidification cracking of 6061-T6 aluminum. Calculated results are compared with data from an experimental program determining the locations of failure as a function of weld process parameters and specimen geometry. Two types of weld solidification cracking specimen were studied. One specimen, in which cracking did not occur, was used to evaluate finite element simulations of the thermal response and calculations of average strain across the weld. The other specimen type was used to determine the location of crack initiation as a function of weld process parameters. This information was used to evaluate the finite element simulations of weld solidification cracking. A solidification model which includes dendrite tip and eutectic undercooling was used in both thermal and mechanical finite element analyses. A strain rate and temperature history dependent constitutive model is coupled with a ductile void growth damage model in the mechanical analyses. Stresses near the weld pool are examined to explain results obtained in the finite element analyses and correlated with experimental observations. Good agreement is obtained between simulation and experiment for locations of crack initiation and extent of cracking. Some effects of uncertainties in material parameters are discussed.

  10. Experimental validation of L-shell x-ray fluorescence computed tomography imaging: phantom study.

    Science.gov (United States)

    Bazalova-Carter, Magdalena; Ahmad, Moiz; Xing, Lei; Fahrig, Rebecca

    2015-10-01

    Thanks to the current advances in nanoscience, molecular biochemistry, and x-ray detector technology, x-ray fluorescence computed tomography (XFCT) has been considered for molecular imaging of probes containing high atomic number elements, such as gold nanoparticles. The commonly used XFCT imaging performed with K-shell x rays appears to have insufficient imaging sensitivity to detect the low gold concentrations observed in small animal studies. Low energy fluorescence L-shell x rays have exhibited higher signal-to-background ratio and appeared as a promising XFCT mode with greatly enhanced sensitivity. The aim of this work was to experimentally demonstrate the feasibility of L-shell XFCT imaging and to assess its achievable sensitivity. We built an experimental L-shell XFCT imaging system consisting of a miniature x-ray tube and two spectrometers, a silicon drift detector (SDD), and a CdTe detector placed at [Formula: see text] with respect to the excitation beam. We imaged a 28-mm-diameter water phantom with 4-mm-diameter Eppendorf tubes containing gold solutions with concentrations of 0.06 to 0.1% Au. While all Au vials were detectable in the SDD L-shell XFCT image, none of the vials were visible in the CdTe L-shell XFCT image. The detectability limit of the presented L-shell XFCT SDD imaging setup was 0.007% Au, a concentration observed in small animal studies.

  11. Infrared Thermography Assessment of Thermal Bridges in Building Envelope: Experimental Validation in a Test Room Setup

    Directory of Open Access Journals (Sweden)

    Francesco Bianchi

    2014-10-01

    Full Text Available Thermal infrared imaging is a valuable tool to perform non-destructive qualitative tests and to investigate buildings envelope thermal-energy behavior. The assessment of envelope thermal insulation, ventilation, air leakages, and HVAC performance can be implemented through the analysis of each thermogram corresponding to an object surface temperature. Thermography also allows the identification of thermal bridges in buildings’ envelope that, together with windows and doors, constitute one of the weakest component increasing thermal losses. A quantitative methodology was proposed in previous researches by the authors in order to evaluate the effect of such weak point on the energy balance of the whole building. In the present work, in-field experimental measurements were carried out with the purpose of evaluating the energy losses through the envelope of a test room experimental field. In-situ thermal transmittance of walls, ceiling and roof were continuously monitored and each element was characterized by its own thermal insulation capability. Infrared thermography and the proposed quantitative methodology were applied to assess the energy losses due to thermal bridges. The main results show that the procedure confirms to be a reliable tool to quantify the incidence of thermal bridges in the envelope thermal losses.

  12. Development and experimental validation of downlink multiuser MIMO-OFDM in gigabit wireless LAN systems

    Science.gov (United States)

    Ishihara, Koichi; Asai, Yusuke; Kudo, Riichi; Ichikawa, Takeo; Takatori, Yasushi; Mizoguchi, Masato

    2013-12-01

    Multiuser multiple-input multiple-output (MU-MIMO) has been proposed as a means to improve spectrum efficiency for various future wireless communication systems. This paper reports indoor experimental results obtained for a newly developed and implemented downlink (DL) MU-MIMO orthogonal frequency division multiplexing (OFDM) transceiver for gigabit wireless local area network systems in the microwave band. In the transceiver, the channel state information (CSI) is estimated at each user and fed back to an access point (AP) on a real-time basis. At the AP, the estimated CSI is used to calculate the transmit beamforming weight for DL MU-MIMO transmission. This paper also proposes a recursive inverse matrix computation scheme for computing the transmit weight in real time. Experiments with the developed transceiver demonstrate its feasibility in a number of indoor scenarios. The experimental results clarify that DL MU-MIMO-OFDM transmission can achieve a 972-Mbit/s transmission data rate with simple digital signal processing of single-antenna users in an indoor environment.

  13. Modeling and Experimental Validation of the Electron Beam Selective Melting Process

    Directory of Open Access Journals (Sweden)

    Wentao Yan

    2017-10-01

    Full Text Available Electron beam selective melting (EBSM is a promising additive manufacturing (AM technology. The EBSM process consists of three major procedures: ① spreading a powder layer, ② preheating to slightly sinter the powder, and ③ selectively melting the powder bed. The highly transient multi-physics phenomena involved in these procedures pose a significant challenge for in situ experimental observation and measurement. To advance the understanding of the physical mechanisms in each procedure, we leverage high-fidelity modeling and post-process experiments. The models resemble the actual fabrication procedures, including ① a powder-spreading model using the discrete element method (DEM, ② a phase field (PF model of powder sintering (solid-state sintering, and ③ a powder-melting (liquid-state sintering model using the finite volume method (FVM. Comprehensive insights into all the major procedures are provided, which have rarely been reported. Preliminary simulation results (including powder particle packing within the powder bed, sintering neck formation between particles, and single-track defects agree qualitatively with experiments, demonstrating the ability to understand the mechanisms and to guide the design and optimization of the experimental setup and manufacturing process.

  14. Accuracies of genomic prediction of feed efficiency traits using different prediction and validation methods in an experimental Nelore cattle population.

    Science.gov (United States)

    Silva, R M O; Fragomeni, B O; Lourenco, D A L; Magalhães, A F B; Irano, N; Carvalheiro, R; Canesin, R C; Mercadante, M E Z; Boligon, A A; Baldi, F S; Misztal, I; Albuquerque, L G

    2016-09-01

    Animal feeding is the most important economic component of beef production systems. Selection for feed efficiency has not been effective mainly due to difficult and high costs to obtain the phenotypes. The application of genomic selection using SNP can decrease the cost of animal evaluation as well as the generation interval. The objective of this study was to compare methods for genomic evaluation of feed efficiency traits using different cross-validation layouts in an experimental beef cattle population genotyped for a high-density SNP panel (BovineHD BeadChip assay 700k, Illumina Inc., San Diego, CA). After quality control, a total of 437,197 SNP genotypes were available for 761 Nelore animals from the Institute of Animal Science, Sertãozinho, São Paulo, Brazil. The studied traits were residual feed intake, feed conversion ratio, ADG, and DMI. Methods of analysis were traditional BLUP, single-step genomic BLUP (ssGBLUP), genomic BLUP (GBLUP), and a Bayesian regression method (BayesCπ). Direct genomic values (DGV) from the last 2 methods were compared directly or in an index that combines DGV with parent average. Three cross-validation approaches were used to validate the models: 1) YOUNG, in which the partition into training and testing sets was based on year of birth and testing animals were born after 2010; 2) UNREL, in which the data set was split into 3 less related subsets and the validation was done in each subset a time; and 3) RANDOM, in which the data set was randomly divided into 4 subsets (considering the contemporary groups) and the validation was done in each subset at a time. On average, the RANDOM design provided the most accurate predictions. Average accuracies ranged from 0.10 to 0.58 using BLUP, from 0.09 to 0.48 using GBLUP, from 0.06 to 0.49 using BayesCπ, and from 0.22 to 0.49 using ssGBLUP. The most accurate and consistent predictions were obtained using ssGBLUP for all analyzed traits. The ssGBLUP seems to be more suitable to obtain

  15. Experimental validation of the ''EasyTest Cell'' operational principle for autonomous MEA characterization

    Energy Technology Data Exchange (ETDEWEB)

    Radev, I. [Institute of Electrochemistry and Energy Systems, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 10, 1113 Sofia (Bulgaria); European Commission, Directorate-General Joint Research Centre, Institute for Energy, PO Box 2, 1755 ZG Petten (Netherlands); Topalov, G.; Slavcheva, E.; Lefterova, E. [Institute of Electrochemistry and Energy Systems, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 10, 1113 Sofia (Bulgaria); Tsotridis, G. [European Commission, Directorate-General Joint Research Centre, Institute for Energy, PO Box 2, 1755 ZG Petten (Netherlands); Schnakenberg, U. [Institute of Materials in Electrical Engineering 1, RWTH-Aachen University, Sommerfeld Str. 24, D-52074 Aachen (Germany)

    2010-03-15

    The paper presents the experimental validation of the ''EasyTest Cell'' operational principle via comparative electrochemical tests on MEAs carried out in three types of electrochemical hydrogen energy conversion (EHEC) testing cells: conventional polymer electrolyte membrane fuel cells (PEMFC) and polymer electrolyte membrane water electrolyzers (PEMWE), properly equipped with all the required auxiliaries (products conditioning and supplying, reagents removal, etc.), and the simple, autonomous EasyTest Cell. Along with EasyTest Cell validation and demonstration of its advantages, the influence of argon pressure during sputtering on the electrode characteristics, including gas diffusion limitations was investigated. The electrodes under investigation were magnetron sputtered C/Ti/IrO{sub x} (IrO{sub x} loading in the range 0.12-0.4 mg cm{sup -2}), C/Ti/IrO{sub x}/Pt/IrO{sub x} (IrO{sub x} 0.08/Pt 0.06/IrO{sub x} 0.08 mg cm{sup -2}), sputtered at various argon pressure C/Ti/Pt (0.15 and 0.25 mg cm{sup -2}), and commercial ELAT electrode (V.21, Lot MB030105-1, Pt loading 0.5 mg cm{sup -2}, E-TEK). The results obtained proved the reliability, simplicity (running-periphery-free) and broadened experimental possibilities of EasyTest Cell over PEMFC and PEMWE single cell testing. Thus, significant cost reduction and resource saving in R and D laboratory can be achieved. Moreover, validation of EasyTest Cell contributes not only to testing facilitations, but potentially to standardization of MEA testing since it gives possibilities for precise control and more uniform distribution of the working parameters applied to the testing object, which are both compulsory for performance comparison and qualifying. (author)

  16. DNA Extraction and Primer Selection

    DEFF Research Database (Denmark)

    Karst, Søren Michael; Nielsen, Per Halkjær; Albertsen, Mads

    Talk regarding pitfalls in DNA extraction and 16S amplicon primer choice when performing community analysis of complex microbial communities. The talk was a part of Workshop 2 "Principles, Potential, and Limitations of Novel Molecular Methods in Water Engineering; from Amplicon Sequencing to -omics...

  17. A Hearing Aid Primer 1

    Science.gov (United States)

    Yetter, Carol J.

    2009-01-01

    This hearing aid primer is designed to define the differences among the three levels of hearing instrument technology: conventional analog circuit technology (most basic), digitally programmable/analog circuit technology (moderately advanced), and fully digital technology (most advanced). Both moderate and advanced technologies mean that hearing…

  18. Freshwater Wetlands: A Citizen's Primer.

    Science.gov (United States)

    Catskill Center for Conservation and Development, Inc., Hobart, NY.

    The purpose of this "primer" for the general public is to describe the general characteristics of wetlands and how wetland alteration adversely affects the well-being of humans. Particular emphasis is placed on wetlands in New York State and the northeast. Topics discussed include wetland values, destruction of wetlands, the costs of…

  19. Experimental validation of calculated capture rate for nucleus involved in fuel cycle; Validation experimentale du calcul du taux de capture des noyaux intervenant dans le cycle du combustible

    Energy Technology Data Exchange (ETDEWEB)

    Benslimane-Bouland, A

    1997-09-01

    The framework of this study was the evaluation of the nuclear data requirements for Actinides and Fission Products applied to current nuclear reactors as well as future applications. This last item includes extended irradiation campaigns, 100 % Mixed Oxide fuel, transmutation or even incineration. The first part of this study presents different types of integral measurements which are available for capture rate measurements, as well as the methods used for reactor core calculation route design and nuclear data library validation. The second section concerns the analysis of three specific irradiation experiments. The results have shown the extent of the current knowledge on nuclear data as well as the associated uncertainties. The third and last section shows both the coherency between all the results, and the statistical method applied for nuclear data library adjustment. A relevant application of this method has demonstrated that only specifically chosen integral experiments can be of use for the validation of nuclear data libraries. The conclusion is reached that even if co-ordinated efforts between reactor and nuclear physicists have made possible a huge improvement in the knowledge of capture cross sections of the main nuclei such as uranium and plutonium, some improvements are currently necessary for the minor actinides (Np, Am and Cm). Both integral and differential measurements are recommended to improve the knowledge of minor actinide cross sections. As far as integral experiments are concerned, a set of criteria to be followed during the experimental conception have been defined in order to both reduce the number of required calculation approximations, and to increase as much as possible the maximum amount of extracted information. (author)

  20. Experimental validation of predicted application accuracies for computer-assisted (CAS) intraoperative navigation with paired-point registration.

    Science.gov (United States)

    Perwög, Martina; Bardosi, Zoltan; Freysinger, Wolfgang

    2017-08-11

    The target registration error (TRE) is a crucial parameter to estimate the potential usefulness of computer-assisted navigation intraoperatively. Both image-to-patient registration on base of rigid-body registration and TRE prediction methods are available for spatially isotropic and anisotropic data. This study presents a thorough validation of data obtained in an experimental operating room setting with CT images. Optical tracking was used to register a plastic skull, an anatomic specimen, and a volunteer to their respective CT images. Plastic skull and anatomic specimen had implanted bone fiducials for registration; the volunteer was registered with anatomic landmarks. Fiducial localization error, fiducial registration error, and total target error (TTE) were measured; the TTE was compared to isotropic and anisotropic error prediction models. Numerical simulations of the experiment were done additionally. The user localization error and the TTE were measured and calculated using predictions, both leading to results as expected for anatomic landmarks and screws used as fiducials. TRE/TTE is submillimetric for the plastic skull and the anatomic specimen. In the experimental data a medium correlation was found between TRE and target localization error (TLE). Most of the predictions of the application accuracy (TRE) fall in the 68% confidence interval of the measured TTE. For the numerically simulated data, a prediction of TTE was not possible; TRE and TTE show a negligible correlation. Experimental application accuracy of computer-assisted navigation could be predicted satisfactorily with adequate models in an experimental setup with paired-point registration of CT images to a patient. The experimental findings suggest that it is possible to run navigation and prediction of navigation application accuracy basically defined by the spatial resolution/precision of the 3D tracker used.

  1. FINAL REPORT on Experimental Validation of Stratified Flow Phenomena, Graphite Oxidation, and Mitigation Strategies of Air Ingress Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Chang H. Oh; Eung S. Kim; Hee C. NO; Nam Z. Cho

    2011-01-01

    The U.S. Department of Energy is performing research and development that focuses on key phenomena that are important during challenging scenarios that may occur in the Next Generation Nuclear Plant (NGNP)/Generation IV very high temperature reactor (VHTR). Phenomena Identification and Ranking studies to date have identified the air ingress event, following on the heels of a VHTR depressurization, as very important. Consequently, the development of advanced air ingress-related models and verification & validation are of very high priority for the NGNP Project. Following a loss of coolant and system depressurization incident, air ingress will occur through the break, leading to oxidation of the in-core graphite structure and fuel. This study indicates that depending on the location and the size of the pipe break, the air ingress phenomena are different. In an effort to estimate the proper safety margin, experimental data and tools, including accurate multidimensional thermal-hydraulic and reactor physics models, a burn-off model, and a fracture model are required. It will also require effective strategies to mitigate the effects of oxidation, eventually. This 3-year project (FY 2008–FY 2010) is focused on various issues related to the VHTR air-ingress accident, including (a) analytical and experimental study of air ingress caused by density-driven, stratified, countercurrent flow, (b) advanced graphite oxidation experiments, (c) experimental study of burn-off in the core bottom structures, (d) structural tests of the oxidized core bottom structures, (e) implementation of advanced models developed during the previous tasks into the GAMMA code, (f) full air ingress and oxidation mitigation analyses, (g) development of core neutronic models, (h) coupling of the core neutronic and thermal hydraulic models, and (i) verification and validation of the coupled models.

  2. ecoPrimers: inference of new DNA barcode markers from whole genome sequence analysis.

    Science.gov (United States)

    Riaz, Tiayyba; Shehzad, Wasim; Viari, Alain; Pompanon, François; Taberlet, Pierre; Coissac, Eric

    2011-11-01

    Using non-conventional markers, DNA metabarcoding allows biodiversity assessment from complex substrates. In this article, we present ecoPrimers, a software for identifying new barcode markers and their associated PCR primers. ecoPrimers scans whole genomes to find such markers without a priori knowledge. ecoPrimers optimizes two quality indices measuring taxonomical range and discrimination to select the most efficient markers from a set of reference sequences, according to specific experimental constraints such as marker length or specifically targeted taxa. The key step of the algorithm is the identification of conserved regions among reference sequences for anchoring primers. We propose an efficient algorithm based on data mining, that allows the analysis of huge sets of sequences. We evaluate the efficiency of ecoPrimers by running it on three different sequence sets: mitochondrial, chloroplast and bacterial genomes. Identified barcode markers correspond either to barcode regions already in use for plants or animals, or to new potential barcodes. Results from empirical experiments carried out on a promising new barcode for analyzing vertebrate diversity fully agree with expectations based on bioinformatics analysis. These tests demonstrate the efficiency of ecoPrimers for inferring new barcodes fitting with diverse experimental contexts. ecoPrimers is available as an open source project at: http://www.grenoble.prabi.fr/trac/ecoPrimers.

  3. Numerical microstructure prediction for an aluminium casting and its experimental validation

    Directory of Open Access Journals (Sweden)

    Unterreiter Guenter

    2011-08-01

    Full Text Available Virtual manufacturing based on through-process modelling becomes an evolving research area which aims at integrating diverse simulation tools to realize computer-aided design, analysis, prototyping and manufacturing. Numerical prediction of the as-cast microstructure is an initial and critical step in the whole through-process modelling chain for engineering components. A commercial software package with the capability of calculating important microstructure features for aluminium alloys is used to simulate a G-AlSi7MgCu0.5 laboratory casting. The simulated microstructure, namely grain size, secondary dendrite arm spacing and diverse phase fractions are verified experimentally. Correspondence and discrepancies are reported and discussed.

  4. Experimental validation of analytical models for a rapid determination of cycle parameters in thermoplastic injection molding

    Science.gov (United States)

    Pignon, Baptiste; Sobotka, Vincent; Boyard, Nicolas; Delaunay, Didier

    2017-10-01

    Two different analytical models were presented to determine cycle parameters of thermoplastics injection process. The aim of these models was to provide quickly a first set of data for mold temperature and cooling time. The first model is specific to amorphous polymers and the second one is dedicated to semi-crystalline polymers taking the crystallization into account. In both cases, the nature of the contact between the polymer and the mold could be considered as perfect or not (thermal contact resistance was considered). Results from models are compared with experimental data obtained with an instrumented mold for an acrylonitrile butadiene styrene (ABS) and a polypropylene (PP). Good agreements were obtained for mold temperature variation and for heat flux. In the case of the PP, the analytical crystallization times were compared with those given by a coupled model between heat transfer and crystallization kinetics.

  5. Experimental and computational validation of a scaled train tunnel model using modal analysis

    Science.gov (United States)

    D'Souza, Janice B.; Kanapathipillai, Sangarapillai

    2013-12-01

    Acoustic engineers are faced with the challenge of minimising reverberation time in their designs so as to contribute to the health and well-being of those traveling by train and those on the platforms. Although the problem is easy to identify, it is not as simple to solve. The acoustical environment of a train tunnel is complex, with a variety of noise contributing factors such as train announcements, speech of commuters, ventilation systems, electrical equipment and wheel and rail noise. As a result, there is some difficulty in modeling the complete acoustic environment with computational or acoustic first principles. In this study, an experimental rig was constructed to model the acoustic behavior within a tunnel. The modal properties for the 300 Hz to 1500 Hz range, including resonances and mode shapes were identified and were shown to successfully correspond to theoretical results and a computational model created in COMSOL using Finite Element Analysis.

  6. Experimental and mumerical validation of the technique for concrete cure monitoring using piezoelectric admittance measurement

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Wan Cheol; Park, Gyu Hae [Dept. of Mechanical Engineering, Chonnam National University, Gwangju (Korea, Republic of)

    2016-06-15

    This paper presents a new technique for monitoring the concrete curing process using embedded piezoelectric transducers via admittance measurements. When a piezoelectric transducer is embedded in a structure, the electrical impedance (admittance) of the transducer is coupled with the mechanical impedance of the host structure, which allows monitoring of the structural condition. In this study, the admittance signatures are used for monitoring the concrete curing process. This new method is based on an admittance-based sensor diagnostic process, in which the capacitance values of the piezoelectric transducers are dependent on the strength of the host structure. We numerically and experimentally investigated the variations in capacitive value during the curing process. The results demonstrate that there is a clear relationship between the concrete curing status and the slope, this indicates that the proposed method could be efficiently used for monitoring the curing status of a concrete structure.

  7. Cross-Validation of Numerical and Experimental Studies of Transitional Airfoil Performance

    DEFF Research Database (Denmark)

    Frere, Ariane; Hillewaert, Koen; Sarlak, Hamid

    2015-01-01

    CFD methodologies, in com- bination with wind tunnel experiments. Large-Eddy Simulations (LES) performed with a novel high order code based on the Discontinuous Galerkin Method are compared to LES from the well established wind turbine CFD code EllipSys3D. Both codes are considering natural transition......The aerodynamic performance characteristic of airfoils are the main input for estimating wind turbine blade loading as well as annual energy production of wind farms. For transitional flow regimes these data are difficult to obtain, both experimentally as well as numerically, due to the very high...... sensitivity of the flow to perturbations, large scale separation and performance hysteresis. The objective of this work is to improve the understanding of the transitional airfoil flow performance by studying the S826 NREL airfoil at low Reynolds numbers (Re = 4:104 and 1:105) with two inherently different...

  8. Experimental validation of a distributed algorithm for dynamic spectrum access in local area networks

    DEFF Research Database (Denmark)

    Tonelli, Oscar; Berardinelli, Gilberto; Tavares, Fernando Menezes Leitão

    2013-01-01

    activities with the Autonomous Component Carrier Selection (ACCS) algorithm, a distributed solution for interference management among small neighboring cells. A preliminary evaluation of the algorithm performance is provided considering its live execution on a software defined radio network testbed......Next generation wireless networks aim at a significant improvement of the spectral efficiency in order to meet the dramatic increase in data service demand. In local area scenarios user-deployed base stations are expected to take place, thus making the centralized planning of frequency resources...... among the cells, a non-viable solution. Cognitive Radio (CR) and Dynamic Spectrum Access (DSA) are the research paradigms which are expected to provide the network nodes the capabilities for an autonomous and efficient selection of the spectrum resources. In this paper we present the first experimental...

  9. Radiation Damage in Nuclear Fuel for Advanced Burner Reactors: Modeling and Experimental Validation

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Niels Gronbech; Asta, Mark; Ozolins, Nigel Browning' Vidvuds; de Walle, Axel van; Wolverton, Christopher

    2011-12-29

    The consortium has completed its existence and we are here highlighting work and accomplishments. As outlined in the proposal, the objective of the work was to advance the theoretical understanding of advanced nuclear fuel materials (oxides) toward a comprehensive modeling strategy that incorporates the different relevant scales involved in radiation damage in oxide fuels. Approaching this we set out to investigate and develop a set of directions: 1) Fission fragment and ion trajectory studies through advanced molecular dynamics methods that allow for statistical multi-scale simulations. This work also includes an investigation of appropriate interatomic force fields useful for the energetic multi-scale phenomena of high energy collisions; 2) Studies of defect and gas bubble formation through electronic structure and Monte Carlo simulations; and 3) an experimental component for the characterization of materials such that comparisons can be obtained between theory and experiment.

  10. Experimental Validation of a Domestic Stratified Hot Water Tank Model in Modelica for Annual Performance Assessment

    DEFF Research Database (Denmark)

    Carmo, Carolina; Dumont, Olivier; Nielsen, Mads Pagh

    2015-01-01

    The use of stratified hot water tanks in solar energy systems - including ORC systems - as well as heat pump systems is paramount for a better performance of these systems. However, the availability of effective and reliable models to predict the annual performance of stratified hot water tanks c...... with direct inlet and outlet and immersed heat exchangers. Results of experimental and numerical investigations in a residential hot water tank with two immersed heat exchangers, one inlet and one outlet are presented and the performance of the model is assessed.......The use of stratified hot water tanks in solar energy systems - including ORC systems - as well as heat pump systems is paramount for a better performance of these systems. However, the availability of effective and reliable models to predict the annual performance of stratified hot water tanks...

  11. 3D CFD Simulation and Experimental Validation of Small APC Slow Flyer Propeller Blade

    Directory of Open Access Journals (Sweden)

    Hairuniza Ahmed Kutty

    2017-02-01

    Full Text Available The current work presents the numerical prediction method to determine small-scale propeller performance. The study is implemented using the commercially available computational fluid dynamics (CFD solver, FLUENT. Numerical results are compared with the available experimental data for an advanced precision composites (APC Slow Flyer propeller blade to determine the discrepancy of the thrust coefficient, power coefficient, and efficiencies. The study utilized unstructured tetrahedron meshing throughout the analysis, with a standard k-ω turbulence model. The Multiple Reference Frame model was also used to consider the rotation of the propeller toward its local reference frame at 3008 revolutions per minute (RPM. Results show reliable thrust coefficient, power coefficient, and efficiency data for the case of low advance ratio and an advance ratio less than the negative thrust conditions.

  12. Measuring incremental changes in word knowledge: experimental validation and implications for learning and assessment.

    Science.gov (United States)

    Frishkoff, Gwen A; Collins-Thompson, Kevyn; Perfetti, Charles A; Callan, Jamie

    2008-11-01

    The goal of this study was to test a new technique for assessing vocabulary development. This technique is based on an algorithm for scoring the accuracy of word definitions using a continuous scale (Collins-Thompson & Callan, 2007). In an experiment with adult learners, target words were presented in six different sentence contexts, and the number of informative versus misleading contexts was systematically manipulated. Participants generated a target definition after each sentence, and the definition-scoring algorithm was used to assess the degree of accuracy on each trial. We observed incremental improvements in definition accuracy across trials. Moreover, learning curves were sensitive to the proportion of misleading contexts, the use of spaced versus massed practice, and individual differences, demonstrating the utility of this procedure for capturing specific experimental effects on the trajectory of word learning. We discuss the implications of these results for measurement of meaning, vocabulary assessment, and instructional design.

  13. Experimental validation of a filament transport model in turbulent magnetized plasmas

    CERN Document Server

    Carralero, D; Aho-Mantila, L; Birkenmeier, G; Brix, M; Groth, M; Müller, H W; Stroth, U; Vianello, N; Wolfrum, E; Contributors, JET

    2015-01-01

    In a wide variety of natural and laboratory magnetized plasmas, filaments appear as a result of interchange instability. These convective structures substantially enhance transport in the direction perpendicular to the magnetic field. According to filament models, their propagation may follow different regimes depending on the parallel closure of charge conservation. This is of paramount importance in magnetic fusion plasmas, as high collisionality in the scrape-off layer may trigger a regime transition leading to strongly enhanced perpendicular particle fluxes. This work reports for the first time on an experimental verification of this process, linking enhanced transport with a regime transition as predicted by models. Based on these results, a novel scaling for global perpendicular particle transport in reactor relevant tokamaks such as ASDEX-Upgrade and JET is found, leading to important implications for next generation fusion devices.

  14. Spin-selective recombination reactions of radical pairs: Experimental test of validity of reaction operators

    Energy Technology Data Exchange (ETDEWEB)

    Maeda, Kiminori [Department of Chemistry, University of Oxford, Centre for Advanced Electron Spin Resonance, Inorganic Chemistry Laboratory, Oxford (United Kingdom); Liddell, Paul; Gust, Devens [Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, 85287-1604 (United States); Hore, P. J. [Department of Chemistry, University of Oxford, Physical and Theoretical Chemistry Laboratory, Oxford (United Kingdom)

    2013-12-21

    Spin-selective reactions of radical pairs are conventionally modelled using an approach that dates back to the 1970s [R. Haberkorn, Mol. Phys. 32, 1491 (1976)]. An alternative approach based on the theory of quantum measurements has recently been suggested [J. A. Jones and P. J. Hore, Chem. Phys. Lett. 488, 90 (2010)]. We present here the first experimental attempt to discriminate between the two models. Pulsed electron paramagnetic resonance spectroscopy has been used to investigate intramolecular electron transfer in the radical pair form of a carotenoid-porphyrin-fullerene molecular triad. The rate of spin-spin relaxation of the fullerene radical in the triad was found to be inconsistent with the quantum measurement description of the spin-selective kinetics, and in accord with the conventional model when combined with spin-dephasing caused by rotational modulation of the anisotropic g-tensor of the fullerene radical.

  15. A Numerical Method of Large-Scale Concrete Displacing Boom Dynamic and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Wu Ren

    2014-01-01

    Full Text Available Concrete displacing boom is large-scale motion manipulator. During the long distance pouring the postures needs to frequently change. This makes the real-time dynamic analysis and health monitoring difficult. Virtual spring-damper method is adopted to establish the equivalent hydraulic actuator model. Besides boom cylinder joint clearance is taken into account. Then transfer matrix method is used to build the multibody concrete placing boom model by dividing the system into two substructures. Next typical working conditions displacements and accelerations during the pouring process are studied. The results of the numerical method are correct and feasible compared with Recurdyn software and the experimental ones. So it provides reference to the real-time monitoring and structure design for such light weight large scale motion manipulators.

  16. Numerical modeling and experimental validation of microstructure in gray cast iron

    Science.gov (United States)

    Jabbari, Masoud; Davami, Parviz; Varahram, Naser

    2012-10-01

    To predict the amount of different phases in gray cast iron by a finite difference model (FDM) on the basis of cooling rate ( R), the volume fractions of total γ phase, graphite, and cementite were calculated. The results of phase composition were evaluated to find a proper correlation with cooling rate. More trials were carried out to find a good correlation between the hardness and phase composition. New proposed formulas show that the hardness of gray cast iron decreases as the amount of graphite phase increases, and increases as the amount of cementite increases. These formulas are developed to correlate the phase volume fraction to hardness. The results are compared with experimental data and show reasonable agreement.

  17. Experimental Validation of Topology Optimization for RF MEMS Capacitive Switch Design

    DEFF Research Database (Denmark)

    Philippine, Mandy Axelle; Zareie, Hosein; Sigmund, Ole

    2013-01-01

    In this paper, we present 30 distinct RF MEMS capacitive switch designs that are the product of topology optimizations that control key mechanical properties such as stiffness, response to intrinsic stress gradients, and temperature sensitivity. The designs were evaluated with high......-accuracy simulations prior to micro-fabrication. We built and tested more than 170 switches, including at least five per distinct design. Experimental results confirm that the finite element models are accurate and that the switches behave as intended by the different optimizations. Extensive testing results include...... actuation and release voltages as a function of temperature, switching times, capacitance ratios, fitted S-parameters, and profile measurements during actuation and over temperature. $\\hfill{[2013\\hbox{-}0203]}$...

  18. Task-Difficulty Homeostasis in Car Following Models: Experimental Validation Using Self-Paced Visual Occlusion.

    Science.gov (United States)

    Pekkanen, Jami; Lappi, Otto; Itkonen, Teemu H; Summala, Heikki

    2017-01-01

    Car following (CF) models used in traffic engineering are often criticized for not incorporating "human factors" well known to affect driving. Some recent work has addressed this by augmenting the CF models with the Task-Capability Interface (TCI) model, by dynamically changing driving parameters as function of driver capability. We examined assumptions of these models experimentally using a self-paced visual occlusion paradigm in a simulated car following task. The results show strong, approximately one-to-one, correspondence between occlusion duration and increase in time headway. The correspondence was found between subjects and within subjects, on aggregate and individual sample level. The long time scale aggregate results support TCI-CF models that assume a linear increase in time headway in response to increased distraction. The short time scale individual sample level results suggest that drivers also adapt their visual sampling in response to transient changes in time headway, a mechanism which isn't incorporated in the current models.

  19. Overview of experimental results and code validation activities at Alcator C-Mod

    Science.gov (United States)

    Greenwald, M.; Bader, A.; Baek, S.; Barnard, H.; Beck, W.; Bergerson, W.; Bespamyatnov, I.; Bitter, M.; Bonoli, P.; Brookman, M.; Brower, D.; Brunner, D.; Burke, W.; Candy, J.; Chilenski, M.; Chung, M.; Churchill, M.; Cziegler, I.; Davis, E.; Dekow, G.; Delgado-Aparicio, L.; Diallo, A.; Ding, W.; Dominguez, A.; Ellis, R.; Ennever, P.; Ernst, D.; Faust, I.; Fiore, C.; Fitzgerald, E.; Fredian, T.; Garcia, O. E.; Gao, C.; Garrett, M.; Golfinopoulos, T.; Granetz, R.; Groebner, R.; Harrison, S.; Harvey, R.; Hartwig, Z.; Hill, K.; Hillairet, J.; Howard, N.; Hubbard, A. E.; Hughes, J. W.; Hutchinson, I.; Irby, J.; James, A. N.; Kanojia, A.; Kasten, C.; Kesner, J.; Kessel, C.; Kube, R.; LaBombard, B.; Lau, C.; Lee, J.; Liao, K.; Lin, Y.; Lipschultz, B.; Ma, Y.; Marmar, E.; McGibbon, P.; Meneghini, O.; Mikkelsen, D.; Miller, D.; Mumgaard, R.; Murray, R.; Ochoukov, R.; Olynyk, G.; Pace, D.; Park, S.; Parker, R.; Podpaly, Y.; Porkolab, M.; Preynas, M.; Pusztai, I.; Reinke, M.; Rice, J.; Rowan, W.; Scott, S.; Shiraiwa, S.; Sierchio, J.; Snyder, P.; Sorbom, B.; Soukhanovskii, V.; Stillerman, J.; Sugiyama, L.; Sung, C.; Terry, D.; Terry, J.; Theiler, C.; Tsujii, N.; Vieira, R.; Walk, J.; Wallace, G.; White, A.; Whyte, D.; Wilson, J.; Wolfe, S.; Woller, K.; Wright, G.; Wright, J.; Wukitch, S.; Wurden, G.; Xu, P.; Yang, C.; Zweben, S.

    2013-10-01

    Recent research on the Alcator C-Mod tokamak has focused on a range of scientific issues with particular emphasis on ITER needs and on detailed comparisons between experimental measurements and predictive models. Research on ICRF (ion cyclotron range of frequencies) heating emphasized the origins and mitigation of metallic impurities while work on lower hybrid current drive experiments have focused on linear and nonlinear wave interactions that limit efficiency at high densities in regimes with low single pass absorption. Experiments in core turbulence and transport focused on quantitative, multi-field comparisons between nonlinear gyro-kinetics simulations and experimental measurements of profiles, fluxes and fluctuations. Experiments into self-generated rotation observed spontaneous flow reversal at a critical density identical to the transition density between linear ohmic confinement and saturated ohmic confinement regimes. H-mode studies have measured pedestal widths consistent with kinetic-ballooning-mode-like instabilities, while the pedestal heights quantitatively match the EPED code predictions. Experiments with I-mode have increased the operating window for this promising edge-localized-mode-free regime. Extrapolation of I-mode to ITER suggests that the fusion gain Q ∼ 10 could be possible in ITER. Investigations into the physics and scaling of the power exhaust channel width in attached enhanced D-alpha H-mode and L-mode plasma showed a direct connection between the midplane pressure-folding length and the outer divertor target footprint. The width was found to scale inversely with IP, while being independent of conducted power, BT or q95 and insensitive to the scrape-off layer connection length—a behaviour that suggests critical-gradient physics sets both pressure and heat-flux profiles.

  20. Underwater behaviour of bitumen coated radioactive wastes: experimental validation of the Colonbo degradation model; Comportement sous eau des dechets radioactifs bitumes: validation experimentale du modele de degradation Colonbo

    Energy Technology Data Exchange (ETDEWEB)

    Gwinner, B

    2004-03-01

    In the release scenario considered for geologic repository, water is thought to be the main aggressive agent with regards to bituminized radioactive waste (composed in general of 60 weight % of bitumen, 40% of soluble/insoluble salts and a few ppm of radionuclides). Since liquid water can diffuse in pure bitumen, leaching of bituminized waste results in the dissolution of the most soluble salts and leads to the development of a more or less concentrated saline solution-filled pore structure (called permeable layer). In consequence of the generation of a porous layer in the bituminized waste, leaching of salts and radionuclides can then take place. Research performed at the Atomic Energy Commission (CEA) aims therefore at understanding the consequences of ground-water immersion on the transport properties and radionuclides leaching of bituminized waste materials. To this end, a constitutive model (called COLONBO) which describes mathematically the leaching of bituminized waste has been developed. The COLONBO model is based on the following assumptions: 1. Water and dissolved salts migrate in the permeable layer according to Fick's first law. The diffusion of water and salts are quantified by effective diffusion coefficients which are unknown. 2. The mechanical properties of the bitumen matrix are not considered during leaching (free swelling). Up to now, the COLONBO model has been used only to model experimental water uptake and salt leach curves, leading (theoretical) estimates of the effective diffusion coefficients of water and salts in the permeable layer. The aim of this work was to validate experimentally the numerical results obtained with the COLONBO model. First, the correspondence between experimental and simulated water uptake and salt leach rates obtained on various bituminized waste materials is checked, leading estimates of the effective diffusion coefficients of water and salts in the permeable layer. Second, the evolution of the thickness and of

  1. Experimental validation of 3D printed patient-specific implants using digital image correlation and finite element analysis.

    Science.gov (United States)

    Sutradhar, Alok; Park, Jaejong; Carrau, Diana; Miller, Michael J

    2014-09-01

    With the dawn of 3D printing technology, patient-specific implant designs are set to have a paradigm shift. A topology optimization method in designing patient-specific craniofacial implants has been developed to ensure adequate load transfer mechanism and restore the form and function of the mid-face. Patient-specific finite element models are used to design these implants and to validate whether they are viable for physiological loading such as mastication. Validation of these topology optimized finite element models using mechanical testing is a critical step. Instead of inserting the implants into a cadaver or patient, we embed the implants into the computer-aided skull model of a patient and, fuse them together to 3D print the complete skull model with the implant. Masticatory forces are applied in the molar region to simulate chewing and measure the stress-strain trajectory. Until recently, strain gages have been used to measure strains for validation. Digital Image Correlation (DIC) method is a relatively new technique for full-field strain measurement which provides a continuous deformation field data. The main objective of this study is to validate the finite element model of patient-specific craniofacial implants against the strain data from the DIC obtained during the mastication simulation and show that the optimized shapes provide adequate load-transfer mechanism. Patient-specific models are obtained from CT scans. The principal maximum and minimum strains are compared. The computational and experimental approach to designing patient-specific implants proved to be a viable technique for mid-face craniofacial reconstruction. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Experimental validation of novel genes predicted in the un-annotated regions of the Arabidopsis genome

    Directory of Open Access Journals (Sweden)

    Town Christopher D

    2007-01-01

    Full Text Available Abstract Background Several lines of evidence support the existence of novel genes and other transcribed units which have not yet been annotated in the Arabidopsis genome. Two gene prediction programs which make use of comparative genomic analysis, Twinscan and EuGene, have recently been deployed on the Arabidopsis genome. The ability of these programs to make use of sequence data from other species has allowed both Twinscan and EuGene to predict over 1000 genes that are intergenic with respect to the most recent annotation release. A high throughput RACE pipeline was utilized in an attempt to verify the structure and expression of these novel genes. Results 1,071 un-annotated loci were targeted by RACE, and full length sequence coverage was obtained for 35% of the targeted genes. We have verified the structure and expression of 378 genes that were not present within the most recent release of the Arabidopsis genome annotation. These 378 genes represent a structurally diverse set of transcripts and encode a functionally diverse set of proteins. Conclusion We have investigated the accuracy of the Twinscan and EuGene gene prediction programs and found them to be reliable predictors of gene structure in Arabidopsis. Several hundred previously un-annotated genes were validated by this work. Based upon this information derived from these efforts it is likely that the Arabidopsis genome annotation continues to overlook several hundred protein coding genes.

  3. Development of Practical Finite Element Models for Collapse of Reinforced Concrete Structures and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Mario Bermejo

    2017-01-01

    Full Text Available This paper describes two practical methodologies for modeling the collapse of reinforced concrete structures. They are validated with a real scale test of a two-floor structure which loses a bearing column. The objective is to achieve accurate simulations of collapse phenomena with moderate computational cost. Explicit finite element models are used with Lagrangian meshes, modeling concrete, and steel in a segregated manner. The first model uses 3D continuum finite elements for concrete and beams for steel bars, connected for displacement compatibility using a penalty method. The second model uses structural finite elements, shells for concrete, and beams for steel, connected in common nodes with an eccentricity formulation. Both are capable of simulating correctly the global behavior of the structural collapse. The continuum finite element model is more accurate for interpreting local failure but has an excessive computational cost for a complete building. The structural finite element model proposed has a moderate computational cost, yields sufficiently accurate results, and as a result is the recommended methodology.

  4. Improvements to a five-phase ABS algorithm for experimental validation

    Science.gov (United States)

    Gerard, Mathieu; Pasillas-Lépine, William; de Vries, Edwin; Verhaegen, Michel

    2012-10-01

    The anti-lock braking system (ABS) is the most important active safety system for passenger cars. Unfortunately, the literature is not really precise about its description, stability and performance. This research improves a five-phase hybrid ABS control algorithm based on wheel deceleration [W. Pasillas-Lépine, Hybrid modeling and limit cycle analysis for a class of five-phase anti-lock brake algorithms, Veh. Syst. Dyn. 44 (2006), pp. 173-188] and validates it on a tyre-in-the-loop laboratory facility. Five relevant effects are modelled so that the simulation matches the reality: oscillations in measurements, wheel acceleration reconstruction, brake pressure dynamics, brake efficiency changes and tyre relaxation. The time delays in measurement and actuation have been identified as the main difficulty for the initial algorithm to work in practice. Three methods are proposed in order to deal with these delays. It is verified that the ABS limit cycles encircle the optimal braking point, without assuming any tyre parameter being a priori known. The ABS algorithm is compared with the commercial algorithm developed by Bosch.

  5. Experimental validation of cost-effective vision-based structural health monitoring

    Science.gov (United States)

    Feng, Dongming; Feng, Maria Q.

    2017-05-01

    Monitoring structural displacement responses can provide quantitative information for both structural safety evaluations and maintenance purposes. To overcome the limitations of conventional displacement sensors, advanced noncontact vision-based systems offer a promising alternative. This study validates the potentials of the vision displacement sensor for cost-effective structural health monitoring. The results of laboratory experiments on simply-supported beam structures demonstrate the high accuracy of the vision sensor for dense full-field displacement measurements. The identified natural frequencies and mode shapes from measurements by using one camera match well with those from an array of accelerometers. Moreover, the smoother mode shapes make possible the noncontact damage detection based on the conventional mode shape curvature index. This study also discusses the issues concerning the practical applications of the vision displacement sensors, such as the scaling factor determination, measurement with small camera tilt angles, tradeoffs between the measurement resolution and measurement points or field of view, etc. Furthermore, the remote, real-time and multi-point measurement capacities of the vision sensor are confirmed through field tests of Manhattan Bridge during train passing.

  6. Temperature Control at DBS Electrodes using Heat Sink: Experimentally Validated FEM Model of DBS lead Architecture

    Science.gov (United States)

    Elwassif, Maged M.; Datta, Abhishek; Rahman, Asif; Bikson, Marom

    2012-01-01

    There is a growing interest in the use of Deep Brain Stimulation for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. The extent of temperature increases around DBS electrodes during normal operation (joule heating and increased metabolic activity) or coupling with an external source (e.g. MRI) remains poorly understood and methods to mitigate temperature increases are being actively investigated. We developed a heat transfer finite element method simulation of DBS incorporating the realistic architecture of Medtronic 3389 leads. The temperature changes were analyzed considering different electrode configurations, stimulation protocols, and tissue properties. The heat-transfer model results were then validated using micro-thermocouple measurements during DBS lead stimulation in a saline bath. FEM results indicate that lead design (materials and geometry) may have a central role in controlling temperature rise by conducting heat. We show how modifying lead design can effectively control temperature increases. The robustness of this heat-sink approach over complimentary heat-mitigation technologies follows from several features: 1) it is insensitive to the mechanisms of heating (e.g. nature of magnetic coupling); 2) does not interfere with device efficacy; and 3) can be practically implemented in a broad range of implanted devices without modifying the normal device operations or the implant procedure. PMID:22764359

  7. PEM fuel cell fault detection and identification using differential method: simulation and experimental validation

    Science.gov (United States)

    Frappé, E.; de Bernardinis, A.; Bethoux, O.; Candusso, D.; Harel, F.; Marchand, C.; Coquery, G.

    2011-05-01

    PEM fuel cell performance and lifetime strongly depend on the polymer membrane and MEA hydration. As the internal moisture is very sensitive to the operating conditions (temperature, stoichiometry, load current, water management…), keeping the optimal working point is complex and requires real-time monitoring. This article focuses on PEM fuel cell stack health diagnosis and more precisely on stack fault detection monitoring. This paper intends to define new, simple and effective methods to get relevant information on usual faults or malfunctions occurring in the fuel cell stack. For this purpose, the authors present a fault detection method using simple and non-intrusive on-line technique based on the space signature of the cell voltages. The authors have the objective to minimize the number of embedded sensors and instrumentation in order to get a precise, reliable and economic solution in a mass market application. A very low number of sensors are indeed needed for this monitoring and the associated algorithm can be implemented on-line. This technique is validated on a 20-cell PEMFC stack. It demonstrates that the developed method is particularly efficient in flooding case. As a matter of fact, it uses directly the stack as a sensor which enables to get a quick feedback on its state of health.

  8. Simulation and experimental validation of droplet dynamics in microchannels of PEM fuel cells

    Science.gov (United States)

    Ashrafi, Moosa; Shams, Mehrzad; Bozorgnezhad, Ali; Ahmadi, Goodarz

    2016-12-01

    In this study, dynamics of droplets in the channels of proton exchange membrane fuel cells with straight and serpentine flow-fields was investigated. Tapered and filleted channels were suggested for the straight and serpentine flow-fields respectively in order to improve water removal in channels. Surface tension and wall adhesion forces were applied by using the volume of fluid method. The hydrophilic walls and hydrophobic gas diffusion layer were considered. The mechanism of droplets movement with different diameters was studied by using the Weber and capillary numbers in simple and tapered straight channels. It was illustrated that the flooding was reduced in tapered channel due to increase of water removal rate, and available reaction sites improved subsequently. In addition, film flow was formed in the tapered channel more than the simple channel, so pressure fluctuation was decreased in the tapered channel. Moreover, the water coverage ratio of hydrophilic tapered surface was more than the simple channel, which enhanced water removal from the channel. The filleted serpentine channel was introduced to improve water removal from the simple serpentine channel. It was shown by observation of the unsteady and time-averaged two-phase pressure drop that in the filleted serpentine channels, the two-phase pressure drop was far less than the simple serpentine channel, and also the accumulation of water droplets in the elbows was less leading to lower pressure fluctuation. The numerical simulation results were validated by experiments.

  9. Experimental validation of the Achromatic Telescopic Squeezing (ATS) scheme at the LHC

    Science.gov (United States)

    Fartoukh, S.; Bruce, R.; Carlier, F.; Coello De Portugal, J.; Garcia-Tabares, A.; Maclean, E.; Malina, L.; Mereghetti, A.; Mirarchi, D.; Persson, T.; Pojer, M.; Ponce, L.; Redaelli, S.; Salvachua, B.; Skowronski, P.; Solfaroli, M.; Tomas, R.; Valuch, D.; Wegscheider, A.; Wenninger, J.

    2017-07-01

    The Achromatic Telescopic Squeezing scheme offers new techniques to deliver unprecedentedly small beam spot size at the interaction points of the ATLAS and CMS experiments of the LHC, while perfectly controlling the chromatic properties of the corresponding optics (linear and non-linear chromaticities, off-momentum beta-beating, spurious dispersion induced by the crossing bumps). The first series of beam tests with ATS optics were achieved during the LHC Run I (2011/2012) for a first validation of the basics of the scheme at small intensity. In 2016, a new generation of more performing ATS optics was developed and more extensively tested in the machine, still with probe beams for optics measurement and correction at β* = 10 cm, but also with a few nominal bunches to establish first collisions at nominal β* (40 cm) and beyond (33 cm), and to analysis the robustness of these optics in terms of collimation and machine protection. The paper will highlight the most relevant and conclusive results which were obtained during this second series of ATS tests.

  10. [Mathematic modeling and experimental validation of macrostate quality expression for multicomponent in Chinese materia medica].

    Science.gov (United States)

    He, Fuyuan; Deng, Kaiwen; Shi, Jilian; Liu, Wenlong; Pi, Fengjuan

    2011-11-01

    To establish the unitive multicomponent quality system bridged macrostate mathematic model parameters of material quality and microstate component concentration for Chinese materia medica (CMM). According to law of biologic laws of thermodynamics, the state functions of macrostate qulity of the CMM were established. The validation test was carried out as modeling drug as alcohol extract of Radix Rhozome (AERR), their enthalpy of combustion was determined, and entropy and the capability of information by chromatographic fingerprint were assayed, and then the biologic apparent macrostate parameters were calculated. The biologic macrostate mathematic models, for the CMM quality controll, were established as parameters as the apparent equilibrium constant, biologic enthalpy, Gibbs free energy and biologic entropy etc. The total molarity for the 10 batchs of AERR were 0.153 4 mmol x g(-1) with 28.26% of RSD, with the average of apparent equilibrium constants, biologic enthalpy, Gibbs free energy and biologic entropy were 0.039 65, 8 005 J x mol(-1), -2.408 x 10(7) J x mol(-1) and - 8.078 x 10(4) J x K(-1) with RSD as 6.020%, 1.860%, 42.32% and 42.31%, respectively. The macrostate quality models for CMM can represent their intrinsic quality for multicomponent dynamic system such as the CMM, to manifest out as if the forest away from or tree near from to see it.

  11. Experimentally validated microstructural 3D constitutive model of coronary arterial media.

    Science.gov (United States)

    Hollander, Yaniv; Durban, David; Lu, Xiao; Kassab, Ghassan S; Lanir, Yoram

    2011-03-01

    Accurate modeling of arterial response to physiological or pathological loads may shed light on the processes leading to initiation and progression of a number of vascular diseases and may serve as a tool for prediction and diagnosis. In this study, a microstructure based hyperelastic constitutive model is developed for passive media of porcine coronary arteries. The most general model contains 12 independent parameters representing the three-dimensional inner fibrous structure of the media and includes the effects of residual stresses and osmotic swelling. Parameter estimation and model validation were based on mechanical data of porcine left anterior descending (LAD) media under radial inflation, axial extension, and twist tests. The results show that a reduced four parameter model is sufficient to reliably predict the passive mechanical properties. These parameters represent the stiffness and the helical orientation of each lamellae fiber and the stiffness of the interlamellar struts interconnecting these lamellae. Other structural features, such as orientational distribution of helical fibers and anisotropy of the interlamellar network, as well as possible transmural distribution of structural features, were found to have little effect on the global media mechanical response. It is shown that the model provides good predictions of the LAD media twist response based on parameters estimated from only biaxial tests of inflation and extension. In addition, good predictive capabilities are demonstrated for the model behavior at high axial stretch ratio based on data of law stretches.

  12. CFD modelling and PIV experimental validation of flow fields in urban environments

    Directory of Open Access Journals (Sweden)

    Gnatowska Renata

    2017-01-01

    Full Text Available The problem of flow field in the urban boundary-layer (UBL in aspects of wind comfort around buildings and pollutant dispersion has grown in importance since human activity has become so intense that it started to have considerable impact on environment. The issue of wind comfort in urban areas is the result of complex interactions of many flow phenomena and for a long time it arouses a great interest of the research centres. The aim of article is to study urban atmospheric flow at the local scale, which allows for both a detailed reproduction of the flow phenomena and the development of wind comfort criteria. The proposed methodology involves the use of PIV wind tunnel experiments as well as numerical simulations (Computational Fluid Dynamics, CFD in order to enhance understanding of the flow phenomena at this particular scale in urban environments. The analysis has been performed for the 3D case of two surface-mounted buildings arranged in tandem, which were placed with one face normal to the oncoming flow. The local characteristics of flow were obtained by the use of commercial CFD code (ANSYS Fluent. The validation was carried out with reference to the PIV results.

  13. A general model for passive balancing of supercritical shafts with experimental validation of friction and collision effects

    Science.gov (United States)

    Haidar, Ahmad M.; Palacios, Jose L.

    2016-12-01

    Passive balancing devices for rotary systems consist of masses that are free to move in concentric guides about a shaft axis. At supercritical speeds, the balancing masses automatically assume positions that counter any imbalance due to uneven mass distribution in the system. A comprehensive physics-based non-linear model of a rotary system with passive balancing was formulated including balancing mass collision and friction. An experiment was conducted to quantify the performance and dynamic behavior of a single-plane passive balancing device and to compare experimental results to model predictions. A parametric study validated the proposed modeling of the balancing mass interaction with other balancing masses and with the balancer track. In this research, the passive balancing device on average reduced shaft transverse vibrations experimentally by 62 percent at steady state. Models available in the literature predicted vibration amplitudes to within 68 percent of the experimental values. The presented model, accounting for balancer track friction and balancing mass collision, improved the accuracy of predicting shaft vibration amplitudes by a factor of 3.9 when compared to published models (18 percent vs. 68 percent).

  14. Numerical simulation and experimental validation of liquid water behaviors in a proton exchange membrane fuel cell cathode with serpentine channels

    Science.gov (United States)

    Le, Anh Dinh; Zhou, Biao; Shiu, Huan-Ruei; Lee, Chun-I.; Chang, Wen-Chen

    The volume-of-fluid (VOF) approach is one of the most promising methods of investigating water transport and water management in proton exchange membrane fuel cells (PEMFCs). A general PEMFC model combined with the VOF method has been developed by our group to simulate the mechanisms of fluid flows, mass and heat transport, and electrochemical reactions in a PEMFC, and it is necessary to validate the numerical model through experiments. In this paper, both the numerical model and an experimental visualization that can simulate the motion and transport behavior of liquid water in a cathode flow channel of a PEMFC are presented. Direct optical visualization is used in this work to capture the droplets' motions with high spatial and temporal resolutions. The numerical model and experimental setup have similar geometric dimensions and operating conditions, and the results of the experiment are in good agreement with numerical simulations. Moreover, the physics of droplet and liquid water behavior based on certain material and liquid properties and the operating conditions in the fuel cell channel are also addressed. This analysis also offers some basic understanding of the mechanism of liquid droplet dynamics in numerical and experimental studies of micro-fluidics.

  15. Homocysteine measurement in pig saliva, assay validation and changes after acute stress and experimental inflammation models: A pilot study.

    Science.gov (United States)

    Tecles, F; Escribano, D; Martínez-Miró, S; Cerón, J J

    2017-06-01

    High homocysteine (Hcy) concentration in serum has been associated to stress and inflammation in humans, but this association has not been studied in saliva in any animal species. The purpose of this research was to study salivary Hcy levels in pigs under stressful and inflammatory conditions. A commercially available enzyme-linked immunosorbent assay specific for Hcy determination in pigs was adapted and validated in saliva, yielding reproducible and accurate results. Hcy was measured in paired serum-saliva samples and no correlation was observed between serum and salivary Hcy. Salivary Hcy was measured in two experimental models of stress induction in pigs: restraint with a nasal snare and isolation. Homocysteine concentration and the homocysteine to total protein (Hcy/TP) ratio significantly increased 15min after restraining and decreased after some days of isolation. Significant correlation was observed between Hcy and chromogranin A. After an experimentally induced inflammation by subcutaneous turpentine injection, salivary Hcy increased only 3h after turpentine administration; however, the Hcy/TP ratio did not show any change. No correlation was found between salivary Hcy and serum C-reactive protein. In conclusion, salivary Hcy concentration increased when pigs were restrained with a nasal snare or stressed by isolation, probably reflecting an increase in the sympathetic activity. On the other hand, Hcy increased after an experimental inflammation induced by turpentine administration but in this case probably reflects an increase in total protein production in saliva. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Variable Modal Parameter Identification for Non-Linear Mdof Systems. Part II: Experimental Validation and Advanced Case Study

    Directory of Open Access Journals (Sweden)

    Y.H. Chong

    2000-01-01

    Full Text Available The purpose of Part II is to provide an experimental validation of the methodology presented in Part I and to consider a representative engineering case, the study of which requires a relatively large numerical model. A beam system with cubic stiffness type non-linearity was used in the experimental study. The non-linear response was measured at three locations and the underlying linear system was obtained via linear modal analysis of low-excitation response data. The non-linear parameter variations were obtained as a function of the modal amplitude and the response of the system was generated for other force levels. The results were found to agree very well with the corresponding measurements, indicating the success of the non-linear modal analysis methodology, even in the presence of true experimental noise. An advanced numerical case study that included both inherent structural damping and non-linear friction damping, was considered next. The linear finite element model of a high-pressure turbine blade was used in conjunction with three local non-linear friction damper elements. It was shown that the response of the system could be predicted at any force level, provided that that non-linear modal parameters were available at some reference force level. The predicted response levels were compared against those obtained from reference simulations and very good agreement was achieved in all cases.

  17. Development and Experimental Validation of a TRNSYS Dynamic Tool for Design and Energy Optimization of Ground Source Heat Pump Systems

    Directory of Open Access Journals (Sweden)

    Félix Ruiz-Calvo

    2017-09-01

    Full Text Available Ground source heat pump (GSHP systems stand for an efficient technology for renewable heating and cooling in buildings. To optimize not only the design but also the operation of the system, a complete dynamic model becomes a highly useful tool, since it allows testing any design modifications and different optimization strategies without actually implementing them at the experimental facility. Usually, this type of systems presents strong dynamic operating conditions. Therefore, the model should be able to predict not only the steady-state behavior of the system but also the short-term response. This paper presents a complete GSHP system model based on an experimental facility, located at Universitat Politècnica de València. The installation was constructed in the framework of a European collaborative project with title GeoCool. The model, developed in TRNSYS, has been validated against experimental data, and it accurately predicts both the short- and long-term behavior of the system.

  18. Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease.

    Science.gov (United States)

    Deng, Yin-Hua; Wang, Ning-Ning; Zou, Zhen-Xing; Zhang, Lin; Xu, Kang-Ping; Chen, Alex F; Cao, Dong-Sheng; Tan, Gui-Shan

    2017-01-01

    Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder which is considered to be the most common cause of dementia. It has a greater impact not only on the learning and memory disturbances but also on social and economy. Currently, there are mainly single-target drugs for AD treatment but the complexity and multiple etiologies of AD make them difficult to obtain desirable therapeutic effects. Therefore, the choice of multi-target drugs will be a potential effective strategy inAD treatment. To find multi-target active ingredients for AD treatment from Selaginella plants, we firstly explored the behaviors effects on AD mice of total extracts (TE) from Selaginella doederleinii on by Morris water maze test and found that TE has a remarkable improvement on learning and memory function for AD mice. And then, multi-target SAR models associated with AD-related proteins were built based on Random Forest (RF) and different descriptors to preliminarily screen potential active ingredients from Selaginella. Considering the prediction outputs and the quantity of existing compounds in our laboratory, 13 compounds were chosen to carry out the in vitro enzyme inhibitory experiments and 4 compounds with BACE1/MAO-B dual inhibitory activity were determined. Finally, the molecular docking was applied to verify the prediction results and enzyme inhibitory experiments. Based on these study and validation processes, we explored a new strategy to improve the efficiency of active ingredients screening based on trace amount of natural product and numbers of targets and found some multi-target compounds with biological activity for the development of novel drugs for AD treatment.

  19. Multi-Target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer's Disease

    Directory of Open Access Journals (Sweden)

    Yin-Hua Deng

    2017-08-01

    Full Text Available Alzheimer's disease (AD is a progressive and irreversible neurodegenerative disorder which is considered to be the most common cause of dementia. It has a greater impact not only on the learning and memory disturbances but also on social and economy. Currently, there are mainly single-target drugs for AD treatment but the complexity and multiple etiologies of AD make them difficult to obtain desirable therapeutic effects. Therefore, the choice of multi-target drugs will be a potential effective strategy inAD treatment. To find multi-target active ingredients for AD treatment from Selaginella plants, we firstly explored the behaviors effects on AD mice of total extracts (TE from Selaginella doederleinii on by Morris water maze test and found that TE has a remarkable improvement on learning and memory function for AD mice. And then, multi-target SAR models associated with AD-related proteins were built based on Random Forest (RF and different descriptors to preliminarily screen potential active ingredients from Selaginella. Considering the prediction outputs and the quantity of existing compounds in our laboratory, 13 compounds were chosen to carry out the in vitro enzyme inhibitory experiments and 4 compounds with BACE1/MAO-B dual inhibitory activity were determined. Finally, the molecular docking was applied to verify the prediction results and enzyme inhibitory experiments. Based on these study and validation processes, we explored a new strategy to improve the efficiency of active ingredients screening based on trace amount of natural product and numbers of targets and found some multi-target compounds with biological activity for the development of novel drugs for AD treatment.

  20. Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation.

    Directory of Open Access Journals (Sweden)

    Thomas O'Hara

    2011-05-01

    Full Text Available Cellular electrophysiology experiments, important for understanding cardiac arrhythmia mechanisms, are usually performed with channels expressed in non myocytes, or with non-human myocytes. Differences between cell types and species affect results. Thus, an accurate model for the undiseased human ventricular action potential (AP which reproduces a broad range of physiological behaviors is needed. Such a model requires extensive experimental data, but essential elements have been unavailable. Here, we develop a human ventricular AP model using new undiseased human ventricular data: Ca(2+ versus voltage dependent inactivation of L-type Ca(2+ current (I(CaL; kinetics for the transient outward, rapid delayed rectifier (I(Kr, Na(+/Ca(2+ exchange (I(NaCa, and inward rectifier currents; AP recordings at all physiological cycle lengths; and rate dependence and restitution of AP duration (APD with and without a variety of specific channel blockers. Simulated APs reproduced the experimental AP morphology, APD rate dependence, and restitution. Using undiseased human mRNA and protein data, models for different transmural cell types were developed. Experiments for rate dependence of Ca(2+ (including peak and decay and intracellular sodium ([Na(+](i in undiseased human myocytes were quantitatively reproduced by the model. Early afterdepolarizations were induced by I(Kr block during slow pacing, and AP and Ca(2+ alternans appeared at rates >200 bpm, as observed in the nonfailing human ventricle. Ca(2+/calmodulin-dependent protein kinase II (CaMK modulated rate dependence of Ca(2+ cycling. I(NaCa linked Ca(2+ alternation to AP alternans. CaMK suppression or SERCA upregulation eliminated alternans. Steady state APD rate dependence was caused primarily by changes in [Na(+](i, via its modulation of the electrogenic Na(+/K(+ ATPase current. At fast pacing rates, late Na(+ current and I(CaL were also contributors. APD shortening during restitution was primarily

  1. Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

    Science.gov (United States)

    O'Hara, Thomas; Virág, László; Varró, András; Rudy, Yoram

    2011-01-01

    Cellular electrophysiology experiments, important for understanding cardiac arrhythmia mechanisms, are usually performed with channels expressed in non myocytes, or with non-human myocytes. Differences between cell types and species affect results. Thus, an accurate model for the undiseased human ventricular action potential (AP) which reproduces a broad range of physiological behaviors is needed. Such a model requires extensive experimental data, but essential elements have been unavailable. Here, we develop a human ventricular AP model using new undiseased human ventricular data: Ca2+ versus voltage dependent inactivation of L-type Ca2+ current (ICaL); kinetics for the transient outward, rapid delayed rectifier (IKr), Na+/Ca2+ exchange (INaCa), and inward rectifier currents; AP recordings at all physiological cycle lengths; and rate dependence and restitution of AP duration (APD) with and without a variety of specific channel blockers. Simulated APs reproduced the experimental AP morphology, APD rate dependence, and restitution. Using undiseased human mRNA and protein data, models for different transmural cell types were developed. Experiments for rate dependence of Ca2+ (including peak and decay) and intracellular sodium ([Na+]i) in undiseased human myocytes were quantitatively reproduced by the model. Early afterdepolarizations were induced by IKr block during slow pacing, and AP and Ca2+ alternans appeared at rates >200 bpm, as observed in the nonfailing human ventricle. Ca2+/calmodulin-dependent protein kinase II (CaMK) modulated rate dependence of Ca2+ cycling. INaCa linked Ca2+ alternation to AP alternans. CaMK suppression or SERCA upregulation eliminated alternans. Steady state APD rate dependence was caused primarily by changes in [Na+]i, via its modulation of the electrogenic Na+/K+ ATPase current. At fast pacing rates, late Na+ current and ICaL were also contributors. APD shortening during restitution was primarily dependent on reduced late Na+ and ICa

  2. Modeling and experimental validation of CO heterogeneous chemistry and electrochemistry in solid oxide fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Yurkiv, Vitaly

    2010-12-17

    In the present work experimental and numerical modeling studies of the heterogeneously catalyzed and electrochemical oxidation of CO at Nickel/yttria-stabilized zirconia (YSZ) solid oxide fuel cell (SOFC) anode systems were performed to evaluate elementary charge-transfer reaction mechanisms taking place at the three-phase boundary of CO/CO{sub 2} gas-phase, Ni electrode, and YSZ electrolyte. Temperature-programmed desorption and reaction experiments along with density functional theory calculations were performed to determine adsorption/desorption and surface diffusion kinetics as well as thermodynamic data for the CO/CO{sub 2}/Ni and CO/CO{sub 2}/YSZ systems. Based on these data elementary reaction based models with four different charge transfer mechanisms for the electrochemical CO oxidation were developed and applied in numerical simulations of literature experimental electrochemical data such as polarization curves and impedance spectra. Comparison between simulation and experiment demonstrated that only one of the four charge transfer mechanisms can consistently reproduce the electrochemical data over a wide range of operating temperatures and CO/CO{sub 2} gas compositions. (orig.) [German] In der vorliegenden Arbeit wurden experimentelle und numerische Untersuchungen zur heterogen katalysierten und elektrochemischen Oxidation von CO an Anodensystemen (bestehend aus Nickel und yttriumdotiertem Zirkoniumdioxid, YSZ) von Festoxidbrennstoffzellen (engl. Solid Oxide Fuel Cells, SOFCs) ausgefuehrt, um den mikroskopischen Mechanismus der an der CO/CO{sub 2}-Gasphase/Ni-Elektrode/YSZ-Elektrolyt- Dreiphasen-Grenzflaeche ablaufenden Ladungsuebertragungsreaktion aufzuklaeren. Temperaturprogrammierte Desorptionsmessungen (TPD) und Temperaturprogrammierte Reaktionsmessungen (TPR) sowie Dichtefunktionaltheorierechnungen wurden ausgefuehrt, um adsorptions-, desorptions- und reaktionskinetische sowie thermodynamische Daten fuer die CO/CO{sub 2}/Ni- und CO/CO{sub 2}/YSZ

  3. Mathematical modeling and experimental validation of Phaeodactylum tricornutum microalgae growth rate with glycerol addition

    Energy Technology Data Exchange (ETDEWEB)

    Morais, Keli Cristiane Correia; Ribeiro, Robert Luis Lara; Santos, Kassiana Ribeiro dos; Mariano, Andre Bellin [Mariano Center for Research and Development of Sustainable Energy (NPDEAS), Curitiba, PR (Brazil); Vargas, Jose Viriato Coelho [Departament of Mechanical Engineering, Federal University of Parana (UFPR) Curitiba, PR (Brazil)

    2010-07-01

    The Brazilian National Program for Bio fuel Production has been encouraging diversification of feedstock for biofuel production. One of the most promising alternatives is the use of microalgae biomass for biofuel production. The cultivation of microalgae is conducted in aquatic systems, therefore microalgae oil production does not compete with agricultural land. Microalgae have greater photosynthetic efficiency than higher plants and are efficient fixing CO{sub 2}. The challenge is to reduce production costs, which can be minimized by increasing productivity and oil biomass. Aiming to increase the production of microalgae biomass, mixotrophic cultivation, with the addition of glycerol has been shown to be very promising. During the production of biodiesel from microalgae there is availability of glycerol as a side product of the transesterification reaction, which could be used as organic carbon source for microalgae mixotrophic growth, resulting in increased biomass productivity. In this paper, to study the effect of glycerol in experimental conditions, the batch culture of the diatom Phaeodactylum tricornutum was performed in a 2-liter flask in a temperature and light intensity controlled room. During 16 days of cultivation, the number of cells per ml was counted periodically in a Neubauer chamber. The calculation of dry biomass in the control experiment (without glycerol) was performed every two days by vacuum filtration. In the dry biomass mixotrophic experiment with glycerol concentration of 1.5 M, the number of cells was assessed similarly in the 10{sup th} and 14{sup th} days of cultivation. Through a volume element methodology, a mathematical model was written to calculate the microalgae growth rate. It was used an equation that describes the influence of irradiation and concentration of nutrients in the growth of microalgae. A simulation time of 16 days was used in the computations, with initial concentration of 0.1 g l{sup -1}. In order to compare

  4. Material characterization and non destructive testing by ultrasounds; modelling, simulation and experimental validation; Caracterisation des materiaux et controle non destructif par ultrasons; modelisation, simulation et validation experimentale

    Energy Technology Data Exchange (ETDEWEB)

    Noroy-Nadal, M.H

    2002-06-15

    This memory presents the research concerning the characterization of materials and the Non Destructive Testing (N.D.T) by ultrasonics. The different topics include three steps: modeling, computations and experimental validation. The studied materials concern mainly metals. The memory is divided in four parts. The first one concerns the characterization of materials versus temperature. The determination of the shear modulus G(T) is especially studied for a large temperature range, and around the melting point. The second part is devoted to studies by photothermal devices essentially focused on the modeling of the mechanical displacement and the stress field in coated materials. In this particular field of interest, applications concern either the mechanical characterization of the coating, the defect detection in the structure and finally the evaluation of the coating adhesion. The third section is dedicated to microstructural characterization using acoustic microscopy. The evaluation of crystallographic texture is especially approached, for metallic objects obtained by forming. Before concluding and pointing out some perspectives to this work, the last section concerns the introduction of optimization techniques, applied to the material characterization by acoustic microscopy. (author)

  5. EXPERIMENTAL VALIDATION OF A MODEL FOR PHOTOVOLTAIC ARRAYS IN TOTAL CROSS-TIED CONFIGURATION

    Directory of Open Access Journals (Sweden)

    CARLOS ANDRÉS RAMOS-PAJA

    2013-01-01

    Full Text Available Este artículo presenta un análisis extendido y la validación experimental de un modelo matemático, basado en el concepto de puntos de inflexión, para arreglos fotovoltaicos en matriz interconectada. El modelo reproduce las características eléctricas de plantas fotovoltaicas reales en condiciones uniformes y no-uniformes (e.g. sombreado parcial. El modelo calcula los voltajes del arreglo en los cuales se activan los diodos de bypass, lo que permite detectar si un módulo fotovoltaico está activo o inactivo para decidir si se considera o desprecia su contribución a la corriente y potencia del arreglo. Este procedimiento genera una reducción significativa en la carga computacional requerida en comparación con soluciones clásicas. Los experimentos reportados en este artículo confirman las ventajas de modelo: baja carga computacional, alta exactitud en la reproducción de datos experimentales, y su utilidad en las evaluaciones energéticas de arreglos fotovoltaicos orientadas al análisis de viabilidad.

  6. Thermodynamic aspects of an LNG tank in fire and experimental validation

    Directory of Open Access Journals (Sweden)

    Hulsbosch-Dam Corina

    2017-01-01

    Full Text Available Mechanical behaviour of a Liquefied Natural Gas (LNG tank and the thermodynamic behaviour of its containment under extreme heat load – for instance when subjected to external fire source as might occur during an accident - are extremely important when addressing safety concerns. In a scenario where external fire is present and consequent release of LNG from pressure relief valves (PRV has occurred, escalation of the fire might occur causing difficulty for the fire response teams to approach the tank or to secure the perimeter. If the duration of the tank exposure to fire is known, the PRV opening time can be estimated based on the thermodynamic calculations. In this paper, such an accidental scenario is considered, relevant thermodynamic equations are derived and presented. Moreover, an experiment is performed with liquid nitrogen and the results are compared to the analytical ones. The analytical results match very well with the experimental observations. The resulting analytical models are suitable to be applied to other cryogenic liquids.

  7. Modelling and experimental validation of thin layer indirect solar drying of mango slices

    Energy Technology Data Exchange (ETDEWEB)

    Dissa, A.O.; Bathiebo, J.; Kam, S.; Koulidiati, J. [Laboratoire de Physique et de Chimie de l' Environnement (LPCE), Unite de Formation et de Recherche en Sciences Exactes et Appliquee (UFR/SEA), Universite de Ouagadougou, Avenue Charles de Gaulle, BP 7021 Kadiogo (Burkina Faso); Savadogo, P.W. [Laboratoire Sol Eau Plante, Institut de l' Environnement et de Recherches Agricoles, 01 BP 476, Ouagadougou (Burkina Faso); Desmorieux, H. [Laboratoire d' Automatisme et de Genie des Procedes (LAGEP), UCBL1-CNRS UMR 5007-CPE Lyon, Bat.308G, 43 bd du 11 Nov. 1918 Villeurbanne, Universite Claude Bernard Lyon1, Lyon (France)

    2009-04-15

    The thin layer solar drying of mango slices of 8 mm thick was simulated and experimented using a solar dryer designed and constructed in laboratory. Under meteorological conditions of harvest period of mangoes, the results showed that 3 'typical days' of drying were necessary to reach the range of preservation water contents. During these 3 days of solar drying, 50%, 40% and 5% of unbound water were eliminated, respectively, at the first, second and the third day. The final water content obtained was about 16 {+-} 1.33% d.b. (13.79% w.b.). This final water content and the corresponding water activity (0.6 {+-} 0.02) were in accordance with previous work. The drying rates with correction for shrinkage and the critical water content were experimentally determined. The critical water content was close to 70% of the initial water content and the drying rates were reduced almost at 6% of their maximum value at night. The thin layer drying model made it possible to simulate suitably the solar drying kinetics of mango slices with a correlation coefficient of r{sup 2} = 0.990. This study thus contributed to the setting of solar drying time of mango and to the establishment of solar drying rates' curves of this fruit. (author)

  8. Experimental validation of a technique to measure tilt from a laser guide star.

    Science.gov (United States)

    Belen'kii, M S; Karis, S J; Brown, J M; Fugate, R Q

    1999-05-15

    We have experimentally demonstrated for what is believed to be the first time a method for sensing wave-front tilt with a laser guide star (LGS). The tilt components of wave fronts were measured synchronously from the LGS by use of a telescope with a 0.75-m effective aperture and from the star Polaris by use of a 1.5-m telescope. The Rayleigh guide star was formed at an altitude of 6 km and at a corresponding range of 10.5 km by projection of a focused beam at Polaris from the full aperture at the 1.5-m telescope. Both telescope mounts were unpowered and bolted in place, allowing us to reduce substantially the telescope vibration. The maximum value of the measured cross-correlation coefficient between the tilt for Polaris and the LGS is 0.71. The variations of the measured cross-correlation coefficient in the range from 0.22 to 0.71 are caused by turbulence at altitudes above 6 km, which was not sampled by the laser beacon but affected tilt for Polaris, the cone effect for turbulence below 6 km, residual mount jitter of the telescopes, and variations of the signal/noise ratio. The results support our concept of sensing atmospheric tilt by observing a LGS with an auxiliary telescope and indicate that this method is a possible solution for the tip-tilt problem.

  9. Finite element modelling of fibre Bragg grating strain sensors and experimental validation

    Science.gov (United States)

    Malik, Shoaib A.; Mahendran, Ramani S.; Harris, Dee; Paget, Mark; Pandita, Surya D.; Machavaram, Venkata R.; Collins, David; Burns, Jonathan M.; Wang, Liwei; Fernando, Gerard F.

    2009-03-01

    Fibre Bragg grating (FBG) sensors continue to be used extensively for monitoring strain and temperature in and on engineering materials and structures. Previous researchers have also developed analytical models to predict the loadtransfer characteristics of FBG sensors as a function of applied strain. The general properties of the coating or adhesive that is used to surface-bond the FBG sensor to the substrate has also been modelled using finite element analysis. In this current paper, a technique was developed to surface-mount FBG sensors with a known volume and thickness of adhesive. The substrates used were aluminium dog-bone tensile test specimens. The FBG sensors were tensile tested in a series of ramp-hold sequences until failure. The reflected FBG spectra were recorded using a commercial instrument. Finite element analysis was performed to model the response of the surface-mounted FBG sensors. In the first instance, the effect of the mechanical properties of the adhesive and substrate were modelled. This was followed by modelling the volume of adhesive used to bond the FBG sensor to the substrate. Finally, the predicted values obtained via finite element modelling were correlated to the experimental results. In addition to the FBG sensors, the tensile test specimens were instrumented with surface-mounted electrical resistance strain gauges.

  10. Classification of SD-OCT Volumes Using Local Binary Patterns: Experimental Validation for DME Detection

    Directory of Open Access Journals (Sweden)

    Guillaume Lemaître

    2016-01-01

    Full Text Available This paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT data for automatic identification of patients with DME versus normal subjects. Optical Coherence Tomography (OCT has been a valuable diagnostic tool for DME, which is among the most common causes of irreversible vision loss in individuals with diabetes. Here, a classification framework with five distinctive steps is proposed and we present an extensive study of each step. Our method considers combination of various preprocessing steps in conjunction with Local Binary Patterns (LBP features and different mapping strategies. Using linear and nonlinear classifiers, we tested the developed framework on a balanced cohort of 32 patients. Experimental results show that the proposed method outperforms the previous studies by achieving a Sensitivity (SE and a Specificity (SP of 81.2% and 93.7%, respectively. Our study concludes that the 3D features and high-level representation of 2D features using patches achieve the best results. However, the effects of preprocessing are inconsistent with different classifiers and feature configurations.

  11. Revisiting Formability and Failure of AISI304 Sheets in SPIF: Experimental Approach and Numerical Validation

    Directory of Open Access Journals (Sweden)

    Gabriel Centeno

    2017-11-01

    Full Text Available Single Point Incremental Forming (SPIF is a flexible and economic manufacturing process with a strong potential for manufacturing small and medium batches of highly customized parts. Formability and failure in SPIF have been intensively discussed in recent years, especially because this process allows stable plastic deformation well above the conventional forming limits, as this enhanced formability is only achievable within a certain range of process parameters depending on the material type. This paper analyzes formability and failure of AISI304-H111 sheets deformed by SPIF compared to conventional testing conditions (including Nakazima and stretch-bending tests. With this purpose, experimental tests in SPIF and stretch-bending were carried out and a numerical model of SPIF is performed. The results allow the authors to establish the following contributions regarding SPIF: (i the setting of the limits of the formability enhancement when small tool diameters are used, (ii the evolution of the crack when failure is attained and (iii the determination of the conditions upon which necking is suppressed, leading directly to ductile fracture in SPIF.

  12. An Experimental Facility to Validate Ground Source Heat Pump Optimisation Models for the Australian Climate

    Directory of Open Access Journals (Sweden)

    Yuanshen Lu

    2017-01-01

    Full Text Available Ground source heat pumps (GSHPs are one of the most widespread forms of geothermal energy technology. They utilise the near-constant temperature of the ground below the frost line to achieve energy-efficiencies two or three times that of conventional air-conditioners, consequently allowing a significant offset in electricity demand for space heating and cooling. Relatively mature GSHP markets are established in Europe and North America. GSHP implementation in Australia, however, is limited, due to high capital price, uncertainties regarding optimum designs for the Australian climate, and limited consumer confidence in the technology. Existing GSHP design standards developed in the Northern Hemisphere are likely to lead to suboptimal performance in Australia where demand might be much more cooling-dominated. There is an urgent need to develop Australia’s own GSHP system optimisation principles on top of the industry standards to provide confidence to bring the GSHP market out of its infancy. To assist in this, the Queensland Geothermal Energy Centre of Excellence (QGECE has commissioned a fully instrumented GSHP experimental facility in Gatton, Australia, as a publically-accessible demonstration of the technology and a platform for systematic studies of GSHPs, including optimisation of design and operations. This paper presents a brief review on current GSHP use in Australia, the technical details of the Gatton GSHP facility, and an analysis on the observed cooling performance of this facility to date.

  13. Numerical model and experimental validation of the heat transfer in air cooled solar photovoltaic panel

    Directory of Open Access Journals (Sweden)

    Ranganathan Senthil Kumar

    2016-01-01

    Full Text Available In this paper, a meticulous numerical model is developed and simulated using computational fluid dynamics technique so as to analyse the heat transfer and temperature distribution on each layer of the air cooled solar photovoltaic panel. The proposed numerical model comprises of bottom air cooling layer and diverse layers of solar panel such as glass, ethyl vinyl acetate, photovoltaic cell, and tedlar. The discrete ordinates model is employed to apply the solar load in the numerical computation. The computational fluid dynamics simulated average temperatures are compared with the experimental measured values and found to be in commendable agreement. The RMSE1, RMSE2, and R-squared values were obtained for top glass, tedlar and outlet air temperature is 1.112949, 0.022619, 0.998175, 0.993115, 0.019556, 0.998451, and 0.077683, 0.022618, 0.988113, respectively. The top glass and photovoltaic cell contour clearly visuvalizes the temperature distribution through out the layer. It is also found that the maximum top glass, photovoltaic cell, tedlar and outlet air temperature of photovoltaic-thermal system are about 58.06°C, 58.39°C, 59.44°C, and 45.48°C, respectively.

  14. Modeling and experimental validation of angular radiance and distance-dependent radiance in a turbid medium

    Science.gov (United States)

    Liu, Lingling; Li, Chenxi; Zhao, Huijuan; Yi, Xi; Gao, Feng; Meng, Wei; Lu, Yiming

    2014-03-01

    Radiance is sensitive to the variations of tissue optical parameters, such as absorption coefficient μa, scattering coefficient μs, and anisotropy factor g. Therefore, similar to fluence, radiance can be used for tissue characterization. Compared with fluence, radiance has the advantage of offering the direction information of light intensity. Taking such advantage, the optical parameters can be determined by rotating the detector through 360 deg with only a single optode pair. Instead of the translation mode used in the fluence-based technologies, the Rotation mode has less invasiveness in the clinical diagnosis. This paper explores a new method to obtain the optical properties by measuring the distribution of light intensity in liquid phantom with only a single optode pair and the detector rotation through 360 deg. The angular radiance and distance-dependent radiance are verified by comparing experimental measurement data with Monte Carlo (MC) simulation for the short source-detector separations and diffusion approximation for the large source-detector separations. Detecting angular radiance with only a single optode pair under a certain source-detection separation will present a way for prostate diagnose and light dose calculation during the photon dynamic therapy (PDT).

  15. Modelling and experimental validation of Textile Pockets based active inflatable device.

    Science.gov (United States)

    Mehmood, A; Basset, M; Orjuela, R; Dupuis, R; Drean, J Y

    2014-11-01

    This paper aims with the mathematical modelling of an active inflatable device. This device is composed of a compressor, an Electro-pneumatic Pressure Converter (EPC) and an Inflatable Textile fabric Pocket (ITP). The later has interesting mechanical properties and is fabricated using Jacquard knitting technique which allows automatic production of unlimited varieties of pattern weaving without any mould. Thanks to these features, these ITPs have provided a better alternative to the classical airbags made by stretchable polymer material. The proposed mathematical model is obtained by combining sub-models of two main parts of the whole system. In this way, a generalised and flexible model is obtained which can easily take into consideration the ITPs of different shapes. The pressure dynamics inside the ITP are considered by taking into account the air flow rate, variation of the volume of ITP and the length of pneumatic lines joining ITP with compressed air source. The parameters of the whole mathematical model are obtained via identification techniques. The effectiveness of the model is assessed through several experimental tests with the help of a servo hydraulic fatigue testing machine. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  16. Experimental validation of the tuneable diaphragm effect in modern acoustic stethoscopes.

    Science.gov (United States)

    Nowak, Karolina M; Nowak, Lukasz J

    2017-09-01

    The force with which the diaphragm chestpiece of a stethoscope is pressed against the body of a patient during an auscultation examination introduces the initial stress and deformation to the diaphragm and the underlying tissues, thus altering the acoustic parameters of the sound transmission path. If the examination is performed by an experienced physician, he will intuitively adjust the amount of the force in order to achieve the optimal sound quality. However, in case of becoming increasingly popular auto-diagnosis and telemedicine auscultation devices with no such feedback mechanisms, the question arises regarding the influence of the possible force mismatch on the parameters of the recorded signal. The present study describes the results of the experimental investigations on the relation between pressure applied to the chestpiece of a stethoscope and parameters of the transmitted bioacoustic signals. The experiments were carried out using various stethoscopes connected to a force measurement system, which allowed to maintain fixed pressure during auscultation examinations. The signals were recorded during examinations of different volunteers, at various auscultation sites. The obtained results reveal strong individual and auscultation-site variability. It is concluded that the underlying tissue deformation is the primary factor that alters the parameters of the recorded signals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. A robust sensorless output feedback controller of the induction motor drives: new design and experimental validation

    Science.gov (United States)

    Ghanes, M.; Barbot, J.-B.; De Leon, J.; Glumineau, A.

    2010-03-01

    In this article, a sensorless output feedback controller is designed in order to drive the induction motor (IM) without the use of flux and speed sensors. First, an observer that uses only the measured stator currents is synthesised to estimate the mechanical variables (speed and load torque) and the magnetic variables (fluxes) by structurally taking into account the unobservability phenomena of the sensorless IM (SIM) and the parametric uncertainties. Second, a current-based field-oriented sliding mode control that uses the flux and the speed estimates given by the former observer is developed so as to steer the estimated speed and flux magnitude to the desired references. Since the observer error dynamic is independent from the known input control and depends on the IM parametric uncertainties, a kind of separation principle is introduced to guarantee the practical stability of the whole closed-loop system 'observer-controller' ('O-C') according to observability and unobservability time variation. A significant benchmark taking into account the unobservability phenomena of the SIM is presented to show the performances of the whole control scheme against experimental set-up.

  18. SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology.

    Science.gov (United States)

    Wang, Liqiang; Qian, Kun; Huang, Yan; Jin, Nana; Lai, Hongyan; Zhang, Ting; Li, Chunhua; Zhang, Chunrui; Bi, Xiaoman; Wu, Deng; Wang, Changliang; Wu, Hao; Tan, Puwen; Lu, Jianping; Chen, Liqun; Li, Kongning; Li, Xia; Wang, Dong

    2015-01-28

    Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a cell. Increasing evidence has also revealed that diverse genetic logic gates capable of generating a Boolean function play critically important roles in synthetic biology. Basic genetic logic gates have been designed to combine biological science with digital logic. SynBioLGDB (http://bioinformatics.ac.cn/synbiolgdb/) aims to provide the synthetic biology community with a useful resource for efficient browsing and visualization of genetic logic gates. The current version of SynBioLGDB documents more than 189 genetic logic gates with experimental evidence involving 80 AND gates and 16 NOR gates, etc. in three species (Human, Escherichia coli and Bacillus clausii). SynBioLGDB provides a user-friendly interface through which conveniently to query and browse detailed information about these genetic logic gates. SynBioLGDB will enable more comprehensive understanding of the connection of genetic logic gates to execute complex cellular functions in living cells.

  19. siRNAmod: A database of experimentally validated chemically modified siRNAs.

    Science.gov (United States)

    Dar, Showkat Ahmad; Thakur, Anamika; Qureshi, Abid; Kumar, Manoj

    2016-01-28

    Small interfering RNA (siRNA) technology has vast potential for functional genomics and development of therapeutics. However, it faces many obstacles predominantly instability of siRNAs due to nuclease digestion and subsequently biologically short half-life. Chemical modifications in siRNAs provide means to overcome these shortcomings and improve their stability and potency. Despite enormous utility bioinformatics resource of these chemically modified siRNAs (cm-siRNAs) is lacking. Therefore, we have developed siRNAmod, a specialized databank for chemically modified siRNAs. Currently, our repository contains a total of 4894 chemically modified-siRNA sequences, comprising 128 unique chemical modifications on different positions with various permutations and combinations. It incorporates important information on siRNA sequence, chemical modification, their number and respective position, structure, simplified molecular input line entry system canonical (SMILES), efficacy of modified siRNA, target gene, cell line, experimental methods, reference etc. It is developed and hosted using Linux Apache MySQL PHP (LAMP) software bundle. Standard user-friendly browse, search facility and analysis tools are also integrated. It would assist in understanding the effect of chemical modifications and further development of stable and efficacious siRNAs for research as well as therapeutics. siRNAmod is freely available at: http://crdd.osdd.net/servers/sirnamod.

  20. SU-E-T-363: Experimentally Validated Pencil Beam Scanning Source Model in TOPAS

    Energy Technology Data Exchange (ETDEWEB)

    Lin, L; Kang, M; Solberg, T; Ainsley, C; McDonough, J [UniversityPennsylvania, Philadelphia, PA (United States)

    2014-06-01

    Purpose: Monte Carlo method can provide the most accurate dose calculation for pencil beam scanning (PBS) proton therapy if the proton sources and particle interaction mechanisms are correct. Methods: TOPAS 1.8, a simulation tool based on Geant4.9.6, was utilized to simulate proton spot profiles. Proton sources, placed at the phantom surface, were modelled with three two-dimensional Gaussian functions to fit measured in-air spot profiles up to 100 mm radius. Simulations were compared with profiles measured using EBT3 film in Solidwater phantoms at various depths from the surface to the end of range for 100, 115, 150, 180, 210 and 225 MeV proton beams with phantom surface locations at 270 mm upstream and at isocentre. Results: Simulation can reproduce one-dimensional integral dose versus radius within 1 mm/1% and two-dimensional profiles within 1 mm out to 0.1% of the central spot dose for all the studied depths of all energies. For two-dimensional 0.01% isodose, simulation can reproduce all 210 MeV proton beam measurements, but cannot predict the diamond-shaped isodose distributions of the 115 MeV beam. When the proton spots are scanned 100 mm off axis, no profile difference can be found between the central axis and the off axis locations for the 210 MeV beam. For the 115 MeV beam, differences of up to 2 mm are observed at the ends of the diamond-shaped 0.01% isodose contour, implying there are lower energy components in the energy spectrum which are less than 4% of the primary energy. Subsequent simulation demonstrates that adopting such an energy spectrum within the source model can improve the distance agreement by 5–6 mm for isodoses below 0.1% near the end of range of the 115 MeV proton beam. Conclusion: Excellent agreement between simulation and measurement validates our PBS source model and the particle interaction mechanism embedded in TOPAS.

  1. Formation of shrinkage porosity during solidification of steel: Numerical simulation and experimental validation

    Science.gov (United States)

    Riedler, M.; Michelic, S.; Bernhard, C.

    2016-07-01

    The phase transformations in solidification of steel are accompanied by shrinkage and sudden changes in the solubility of alloying elements, resulting in negative side effects as micro- and macrosegregation and the formation of gas and shrinkage porosities. This paper deals with the numerical and experimental simulation of the formation of shrinkage porosity during the solidification of steel. First the physical basics for the mechanism of shrinkage pore formation will be discussed. The main reason for this type of porosity is the restraint of fluid flow in the mushy zone which leads to a pressure drop. The pressure decreases from the dendrite tip to the root. When the pressure falls below a critical value, a pore can form. The second part of the paper deals with different approaches for the prediction of the formation of shrinkage porosity. The most common one according to these models is the usage of a simple criterion function, like the Niyama criterion. For the computation of the porosity criterion the thermal gradient, cooling rate and solidification rate must be known, easily to determine from numerical simulation. More complex simulation tools like ProCAST include higher sophisticated models, which allow further calculations of the shrinkage cavity. Finally, the different approaches will be applied to a benchmark laboratory experiment. The presented results deal with an ingot casting experiment under variation of taper. The dominant influence of mould taper on the formation of shrinkage porosities can both be demonstrated by the lab experiment as well as numerical simulations. These results serve for the optimization of all ingot layouts for lab castings at the Chair of Ferrous Metallurgy.

  2. A transverse oscillation approach for estimation of three-dimensional velocity vectors, part II: experimental validation.

    Science.gov (United States)

    Pihl, Michael Johannes; Stuart, Matthias Bo; Tomov, Borislav Gueorguiev; Rasmussen, Morten Fischer; Jensen, Jørgen Arendt

    2014-10-01

    The 3-D transverse oscillation method is investigated by estimating 3-D velocities in an experimental flow-rig system. Measurements of the synthesized transverse oscillating fields are presented as well. The method employs a 2-D transducer; decouples the velocity estimation; and estimates the axial, transverse, and elevation velocity components simultaneously. Data are acquired using a research ultrasound scanner. The velocity measurements are conducted with steady flow in sixteen different directions. For a specific flow direction with [α, ß] = [45, 15]°, the mean estimated velocity vector at the center of the vessel is (v(x), v(y), v(z)) = (33.8, 34.5, 15.2) ± (4.6, 5.0, 0.6) cm/s where the expected velocity is (34.2, 34.2, 13.0) cm/s. The velocity magnitude is 50.6 ± 5.2 cm/s with a bias of 0.7 cm/s. The flow angles α and ß are estimated as 45.6 ± 4.9° and 17.6 ± 1.0°. Subsequently, the precision and accuracy are calculated over the entire velocity profiles. On average for all direction, the relative mean bias of the velocity magnitude is -0.08%. For α and ß, the mean bias is -0.2° and -1.5°. The relative standard deviations of the velocity magnitude ranges from 8 to 16%. For the flow angles, the ranges of the mean angular deviations are 5° to 16° and 0.7° and 8°.

  3. Design and experimental validation of novel 3D optical scanner with zoom lens unit

    Science.gov (United States)

    Huang, Jyun-Cheng; Liu, Chien-Sheng; Chiang, Pei-Ju; Hsu, Wei-Yan; Liu, Jian-Liang; Huang, Bai-Hao; Lin, Shao-Ru

    2017-10-01

    Optical scanners play a key role in many three-dimensional (3D) printing and CAD/CAM applications. However, existing optical scanners are generally designed to provide either a wide scanning area or a high 3D reconstruction accuracy from a lens with a fixed focal length. In the former case, the scanning area is increased at the expense of the reconstruction accuracy, while in the latter case, the reconstruction performance is improved at the expense of a more limited scanning range. In other words, existing optical scanners compromise between the scanning area and the reconstruction accuracy. Accordingly, the present study proposes a new scanning system including a zoom-lens unit, which combines both a wide scanning area and a high 3D reconstruction accuracy. In the proposed approach, the object is scanned initially under a suitable low-magnification setting for the object size (setting 1), resulting in a wide scanning area but a poor reconstruction resolution in complicated regions of the object. The complicated regions of the object are then rescanned under a high-magnification setting (setting 2) in order to improve the accuracy of the original reconstruction results. Finally, the models reconstructed after each scanning pass are combined to obtain the final reconstructed 3D shape of the object. The feasibility of the proposed method is demonstrated experimentally using a laboratory-built prototype. It is shown that the scanner has a high reconstruction accuracy over a large scanning area. In other words, the proposed optical scanner has significant potential for 3D engineering applications.

  4. Numerical Simulation and Experimental Validation for the Thermal Analysis of a Compact LED Recessed Downlight with Heat Sink Design

    Directory of Open Access Journals (Sweden)

    Huan-Chu Hsu

    2016-12-01

    Full Text Available Light emitting diode (LED-recessed downlighting is currently mainly used for indoor lighting of residential and commercial buildings. Maintaining a low junction temperature and increasing the lifetime and reliability of LED lighting is desirable. This study investigated designed heat sinks’ heat dissipation and capability of maintaining a low junction temperature, as well as increases in the lifetime and reliability of the lighting. This paper presents a designed traditional trapezoidal aluminum finned heat sink (ALFHS and annular open cell copper foam heat sink (CUFHS mounted to a 10 W compact LED-recessed downlight (CLRDL and individually installed in a simulation 105 mm × 105 mm × 100 mm (L × W × H test box. The purpose was to evaluate the temperature performance by testing the downlight in a small enclosed space with high ambient temperature while the LED is in operation. The downlight exhibited a long lifetime at normal use temperature and functioned according to Arrhenius’ law. Numerical simulation was performed first and followed by experimental validation. The heat sink design was the main factor in the heat management of the CLRDL. The heat sinks height was determined using numerical simulation and experimental validation before and after installation (INST of the ALFHS and CUFHS. The CUFHS height was initially selected based on a larger heat dissipation capacity, and then by determining the ALFHS height. Both the ALFHS and CUFHS with the same height of 17 mm exhibited a similar capacity of heat dissipation before INST. Subsequent to INST, the temperature of the solder point of the ALFHS was higher than that of the CUFHS with an identical height of 17 mm. To compare the heat dissipation behavior of the two heat sinks, the ALFHS height was increased to 23 mm, which is 6 mm higher than that of the CUFHS. The results of a stationary simulation study for junction temperature coincides with the experimental results tested obtained

  5. FY-09 Report: Experimental Validation of Stratified Flow Phenomena, Graphite Oxidation, and Mitigation Strategies of Air Ingress Accidents

    Energy Technology Data Exchange (ETDEWEB)

    Chang H. Oh; Eung S. Kim

    2009-12-01

    The Idaho National Laboratory (INL), under the auspices of the U.S. Department of Energy, is performing research and development that focuses on key phenomena important during potential scenarios that may occur in the Next Generation Nuclear Plant (NGNP)/Gen-IV very high temperature reactor (VHTR). Phenomena Identification and Ranking Studies to date have identified that an air ingress event following on the heels of a VHTR depressurization is a very important incident. Consequently, the development of advanced air ingress-related models and verification and validation data are a very high priority for the NGNP Project. Following a loss of coolant and system depressurization incident, air will enter the core through the break, leading to oxidation of the in-core graphite structure and fuel. If this accident occurs, the oxidation will accelerate heat-up of the bottom reflector and the reactor core and will eventually cause the release of fission products. The potential collapse of the core bottom structures causing the release of CO and fission products is one of the concerns. Therefore, experimental validation with the analytical model and computational fluid dynamic (CFD) model developed in this study is very important. Estimating the proper safety margin will require experimental data and tools, including accurate multidimensional thermal-hydraulic and reactor physics models, a burn-off model, and a fracture model. It will also require effective strategies to mitigate the effects of oxidation. The results from this research will provide crucial inputs to the INL NGNP/VHTR Methods Research and Development project. The second year of this three-year project (FY-08 to FY-10) was focused on (a) the analytical, CFD, and experimental study of air ingress caused by density-driven, stratified, countercurrent flow; (b) advanced graphite oxidation experiments and modeling; (c) experimental study of burn-off in the core bottom structures, (d) implementation of advanced

  6. Hierarchical path planning and control of a small fixed-wing UAV: Theory and experimental validation

    Science.gov (United States)

    Jung, Dongwon

    2007-12-01

    problem is formulated by setting up geometric linear constraints as well as boundary conditions. Subsequently, we construct B-spline path templates by solving a set of distinct optimization problems. For application in UAV motion planning, the path templates are incorporated to replace parts of the entire path by the smooth B-spline paths. Each path segment is stitched together while preserving continuity to obtain a final smooth reference path to be used for path following control. The path following control for a small fixed-wing UAV to track the prescribed smooth reference path is also addressed. Assuming the UAV is equipped with an autopilot for low level control, we adopt a kinematic error model with respect to the moving Serret-Frenet frame attached to a path for tracking controller design. A kinematic path following control law that commands heading rate is presented. Backstepping is applied to derive the roll angle command by taking into account the approximate closed-loop roll dynamics. A parameter adaptation technique is employed to account for the inaccurate time constant of the closed-loop roll dynamics during actual implementation. Finally, we implement the proposed hierarchical path control of a small UAV on the actual hardware platform, which is based on an 1/5 scale R/C model airframe (Decathlon) and the autopilot hardware and software. Based on the hardware-in-the-loop (HIL) simulation environment, the proposed hierarchical path control algorithm has been validated through on-line, real-time implementation on a small micro-controller. By a seamless integration of the control algorithms for path planning, path smoothing, and path following, it has been demonstrated that the UAV equipped with a small autopilot having limited computational resources manages to accomplish the path control objective to reach the goal while avoiding obstacles with minimal human intervention.

  7. Modeling and Experimental Validation for Tsunamis Generated by Submarine Mass Failure

    Science.gov (United States)

    Enet, F.; Grilli, S. T.; Watts, P.; Kirby, J. T.

    2003-12-01

    Numerical models of tsunamis generation by Submarine Mass Failure (SMF) were developed in earlier work by the authors. More recently, this included a three-dimensional (3D) SMF tsunami source model, based on Fully Nonlinear Potential Flow equations (FNPF) (Grilli et al., 2002), and the integration of this model into a Boussinesq wave propagation and runup model (Watts et al., 2003a). The combined model for SMF tsunami generation, propagation, and runup, referred to as GEOWAVE, was successfully applied to a number of case studies, including PNG 1998, Skagway 1994, and Unimak 1946 (e.g., Watts et al., 2003ab). In the present work, we first describe recent improvements made to the model components of GEOWAVE, and their application to historical case studies. One recent addition to the Boussinesq propagation model, in particular, is its implementation in spherical coordinates, which allows using it over larger scale tsunami propagation areas. This is useful to study both transoceanic SMF tsunami near- and far-field propagation within the same dispersive long wave model. Second, we report results of recent large scale three-dimensional experiments performed at the University of Rhode Island, to investigate tsunami generation by underwater landslides. Each experiment consists of a solid landslide of idealized smooth shape sliding over a plane slope. Surface elevations are measured using capacitance gages placed at strategic locations. Gage calibration is performed using a newly developed automated system. Runup at the shoreline is measured using a remotely operated digital camera. Landslide acceleration is measured with a micro-accelerometer embedded at the landslide center of mass and an optical system also measures landslide displacement, as a way of cross-validation. The repeatability of experiments is first investigated, and then by varying the initial depth of the landslide, different conditions of wave non-linearity and dispersion are generated and compared. Third

  8. Bioinformatic tools for PCR Primer design

    African Journals Online (AJOL)

    ES

    choosing the most efficient way to design a new specific-primer by applying current publicly available links and Web services. Also, the purpose here is to provide general recommendations for the design and use of PCR primers. Key words: Bio-computing, primer design, web-based resources. INTRODUCTION. In the last ...

  9. Use of Modern Chemical Protein Synthesis and Advanced Fluorescent Assay Techniques to Experimentally Validate the Functional Annotation of Microbial Genomes

    Energy Technology Data Exchange (ETDEWEB)

    Kent, Stephen [University of Chicago

    2012-07-20

    The objective of this research program was to prototype methods for the chemical synthesis of predicted protein molecules in annotated microbial genomes. High throughput chemical methods were to be used to make large numbers of predicted proteins and protein domains, based on microbial genome sequences. Microscale chemical synthesis methods for the parallel preparation of peptide-thioester building blocks were developed; these peptide segments are used for the parallel chemical synthesis of proteins and protein domains. Ultimately, it is envisaged that these synthetic molecules would be ‘printed’ in spatially addressable arrays. The unique ability of total synthesis to precision label protein molecules with dyes and with chemical or biochemical ‘tags’ can be used to facilitate novel assay technologies adapted from state-of-the art single molecule fluorescence detection techniques. In the future, in conjunction with modern laboratory automation this integrated set of techniques will enable high throughput experimental validation of the functional annotation of microbial genomes.

  10. EXPERIMENTAL VALIDATION OF A DUAL LOOP CONTROL OF TWO PHASES INTERLEAVED BOOST CONVERTER FOR FUEL CELL APPLICATIONS

    Directory of Open Access Journals (Sweden)

    O. Kraa

    2016-05-01

    Full Text Available In this paper, a modelling, an implementation and a control of a dc-dc converter structure called “two phases Interleaved Boost Converter (IBC” will be presented. This topology is widely used in order to reduce the input current ripples and the size of passive component with high efficiency. The control of the IBC converter is designed by dual loop control that contains a voltage loop with a linear PI controller and a fast current loop with a non-linear sliding controller to ensure a good tracking in steady state and fast performance in transient state. The proposed control loop has been validated, first by the simulation results under Matlab-Simulink and after by the experimental results using a small-scale test bench with the dSPACE-1104 card.

  11. Optimal control model predictions of system performance and attention allocation and their experimental validation in a display design study

    Science.gov (United States)

    Johannsen, G.; Govindaraj, T.

    1980-01-01

    The influence of different types of predictor displays in a longitudinal vertical takeoff and landing (VTOL) hover task is analyzed in a theoretical study. Several cases with differing amounts of predictive and rate information are compared. The optimal control model of the human operator is used to estimate human and system performance in terms of root-mean-square (rms) values and to compute optimized attention allocation. The only part of the model which is varied to predict these data is the observation matrix. Typical cases are selected for a subsequent experimental validation. The rms values as well as eye-movement data are recorded. The results agree favorably with those of the theoretical study in terms of relative differences. Better matching is achieved by revised model input data.

  12. Numerical Determination and Experimental Validation of a Technological Specimen Representative of High-Pressure Hydrogen Storage Vessels

    Science.gov (United States)

    Gentilleau, B.; Touchard, F.; Grandidier, J.-C.; Mellier, D.

    2015-09-01

    A technological specimen representative of type IV high-pressure hydrogen storage vessels is developed. An analytical model is used to compute fiber orientations in the specimen in order to be as representative as possible of the stress level reached in a tank during pressurization. A three-dimensional finite-element model is used to determine the best stacking sequence with these fiber orientations. A validation is done by performing tests with digital image correlation in order to measure displacements on the lateral side of the specimen. A comparison between the calculated and experimentally found strain fields is made. The results obtained highlight the influence of stacking sequence on the development of damage and the difficulty arising in designing representative specimens.

  13. Modelling and experimental validation for off-design performance of the helical heat exchanger with LMTD correction taken into account

    Energy Technology Data Exchange (ETDEWEB)

    Phu, Nguyen Minh; Trinh, Nguyen Thi Minh [Vietnam National University, Ho Chi Minh City (Viet Nam)

    2016-07-15

    Today the helical coil heat exchanger is being employed widely due to its dominant advantages. In this study, a mathematical model was established to predict off-design works of the helical heat exchanger. The model was based on the LMTD and e-NTU methods, where a LMTD correction factor was taken into account to increase accuracy. An experimental apparatus was set-up to validate the model. Results showed that errors of thermal duty, outlet hot fluid temperature, outlet cold fluid temperature, shell-side pressure drop, and tube-side pressure drop were respectively +-5%, +-1%, +-1%, +-5% and +-2%. Diagrams of dimensionless operating parameters and a regression function were also presented as design-maps, a fast calculator for usage in design and operation of the exchanger. The study is expected to be a good tool to estimate off-design conditions of the single-phase helical heat exchangers.

  14. Study of the occlusion effect induced by an earplug: Numerical modelling and experimental validation

    Science.gov (United States)

    Brummund, Martin

    (IRSST) and the Ecole de technologie superieure (ETS) has been launched. The present study represents a part of this collaboration and aims at studying the occlusion effect of the system earplug - ear canal through the development of novel numerical models and experimental methods. (Abstract shortened by UMI.).

  15. Numerical calculation and experimental validation of damage development in 9 Cr steels

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, M.; Maile, K.; Ringel, M. [Stuttgart Univ. (Germany). Materialpruefungsanstalt

    2004-07-01

    The investigations carried out for hollow cylinder specimens under multiaxial stress state for the materials 14MoV6-3, 10CrMo9-10, X10CrMoVNb9-1 and X11CrMoWVNb9-1-1 permit a comparative view on the damage development under service like loading conditions. All samples experienced relatively low rupture deformation values within the range < 5%, reflecting real component behaviour. Also the creep damage behaviour, well-known from components made of 14MoV6-3, can be identified in the frame of the experimental work: a significant number of creep cavities of clearly > 100 mm{sup -2} were already found at creep strains < 1%. Thus, the operational experience and the results of component tests is confirmed, that creep cavity occur within the range of approximately 50% of the service life. In contrast to this are the results of the steel X10CrMoVNb9-1: the creep cavities initiate at clearly larger creep strains, the number per unit area is rather small. With a cavity density of partially < 50 mm{sup -2} the problem of uncertainty results, that the cavities identified have also to be considered as artefacts. Life time assessment and damage evaluation of components made of modern martensitic steels therefore must be based on a more realistic calculation of the life time consumption. In this case it is necessary to include the multiaxiality of stress state in the material model used in finite element simulations. A first step is the usage of a mathematical description of the creep cavity density with respect to deformation and multiaxiality, which was determined for P91 at 600 C. Using this equation it is possible to calculate for the creep cavity density in a component. More research work has to be done in order to model the influence of the damage itself on the further development of stress and strain. (orig.)

  16. An experimentally validated model for geometrically nonlinear plucking-based frequency up-conversion in energy harvesting

    Science.gov (United States)

    Kathpalia, B.; Tan, D.; Stern, I.; Erturk, A.

    2018-01-01

    It is well known that plucking-based frequency up-conversion can enhance the power output in piezoelectric energy harvesting by enabling cyclic free vibration at the fundamental bending mode of the harvester even for very low excitation frequencies. In this work, we present a geometrically nonlinear plucking-based framework for frequency up-conversion in piezoelectric energy harvesting under quasistatic excitations associated with low-frequency stimuli such as walking and similar rigid body motions. Axial shortening of the plectrum is essential to enable plucking excitation, which requires a nonlinear framework relating the plectrum parameters (e.g. overlap length between the plectrum and harvester) to the overall electrical power output. Von Kármán-type geometrically nonlinear deformation of the flexible plectrum cantilever is employed to relate the overlap length between the flexible (nonlinear) plectrum and the stiff (linear) harvester to the transverse quasistatic tip displacement of the plectrum, and thereby the tip load on the linear harvester in each plucking cycle. By combining the nonlinear plectrum mechanics and linear harvester dynamics with two-way electromechanical coupling, the electrical power output is obtained directly in terms of the overlap length. Experimental case studies and validations are presented for various overlap lengths and a set of electrical load resistance values. Further analysis results are reported regarding the combined effects of plectrum thickness and overlap length on the plucking force and harvested power output. The experimentally validated nonlinear plectrum–linear harvester framework proposed herein can be employed to design and optimize frequency up-conversion by properly choosing the plectrum parameters (geometry, material, overlap length, etc) as well as the harvester parameters.

  17. Experimental validation of wavelet based solution for dynamic response of railway track subjected to a moving train

    Science.gov (United States)

    Koziol, Piotr

    2016-10-01

    New approaches allowing effective analysis of railway structures dynamic behaviour are needed for appropriate modelling and understanding of phenomena associated with train transportation. The literature highlights the fact that nonlinear assumptions are of importance in dynamic analysis of railway tracks. This paper presents wavelet based semi-analytical solution for the infinite Euler-Bernoulli beam resting on a nonlinear foundation and subjected to a set of moving forces, being representation of railway track with moving train, along with its preliminary experimental validation. It is shown that this model, although very simplified, with an assumption of viscous damping of foundation, can be considered as a good enough approximation of realistic structures behaviour. The steady-state response of the beam is obtained by applying the Galilean co-ordinate system and the Adomian's decomposition method combined with coiflet based approximation, leading to analytical estimation of transverse displacements. The applied approach, using parameters taken from real measurements carried out on the Polish Railways network for fast train Pendolino EMU-250, shows ability of the proposed method to analyse parametrically dynamic systems associated with transportation. The obtained results are in accordance with measurement data in wide range of physical parameters, which can be treated as a validation of the developed wavelet based approach. The conducted investigation is supplemented by several numerical examples.

  18. Development and Validation of LC Method for the Determination of Famciclovir in Pharmaceutical Formulation Using an Experimental Design

    Directory of Open Access Journals (Sweden)

    Srinivas Vishnumulaka

    2008-01-01

    Full Text Available A rapid and sensitive RP-HPLC method with UV detection (242 nm for routine analysis of famciclovir in pharmaceutical formulations was developed. Chromatography was performed with mobile phase containing a mixture of methanol and phosphate buffer (50:50, v/v with flow rate 1.0 mL min−1. Quantitation was accomplished with internal standard method. The procedure was validated for linearity (correlation coefficient =0.9999, accuracy, robustness and intermediate precision. Experimental design was used for validation of robustness and intermediate precision. To test robustness, three factors were considered; percentage v/v of methanol in mobile phase, flow rate and pH; flow rate, the percentage of organic modifier and pH have considerable important effect on the response. For intermediate precision measure the variables considered were: analyst, equipment and number of days. The RSD value (0.86%, n=24 indicated an acceptable precision of the analytical method. The proposed method was simple, sensitive, precise, accurate and quick and useful for routine quality control.

  19. Numerical verification and experimental validation of the FEM model of collecting electrodes in a dry electrostatic precipitator

    Directory of Open Access Journals (Sweden)

    Andrzej Nowak

    Full Text Available The subject of the present work is the numerical verification and experimental validation of the FEM model which would enable us to analyse the vibrations of collecting electrodes. The effectiveness of electrostatic precipitators (ESP depends on many factors. One of these factors is the efficiency of periodic cleaning of the collecting electrodes; thus the dust is removed by inducing vibrations. These vibrations are caused by the axial impact of a hammer on an anvil beam. In the course of the impact, and afterwards, the stresses due to the impact are produced in both the rapper system and in the collecting electrode section. The paper presents a modified finite element method which can be used in simulations and to analyse the vibrations of collecting electrodes. In the verification process the calculation results obtained were compared with those from commercial software (Abaqus. The calculations and measured results were compared for validation. The comparisons were made using peak and RMS (root-mean-squared values as well as special factors and hit rates. An acceptable compatibility of the results proves that the model can be applied in the analysis of vibrations of electrodes in design practice.

  20. Validation of High-Fidelity Reactor Physics Models for Support of the KJRR Experimental Campaign in the Advanced Test Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Nigg, David W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Nielsen, Joseph W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Norman, Daren R. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-07-01

    The Korea Atomic Energy Research Institute is currently in the process of qualifying a Low-Enriched Uranium fuel element design for the new Ki-Jang Research Reactor (KJRR). As part of this effort, a prototype KJRR fuel element was irradiated for several operating cycles in the Northeast Flux Trap of the Advanced Test Reactor (ATR) at the Idaho National Laboratory. The KJRR fuel element contained a very large quantity of fissile material (618g 235U) in comparison with historical ATR experiment standards (<1g 235U), and its presence in the ATR flux trap was expected to create a neutronic configuration that would be well outside of the approved validation envelope for the reactor physics analysis methods used to support ATR operations. Accordingly it was necessary, prior to high-power irradiation of the KJRR fuel element in the ATR, to conduct an extensive set of new low-power physics measurements with the KJRR fuel element installed in the ATR Critical Facility (ATRC), a companion facility to the ATR that is located in an immediately adjacent building, sharing the same fuel handling and storage canal. The new measurements had the objective of expanding the validation envelope for the computational reactor physics tools used to support ATR operations and safety analysis to include the planned KJRR irradiation in the ATR and similar experiments that are anticipated in the future. The computational and experimental results demonstrated that the neutronic behavior of the KJRR fuel element in the ATRC is well-understood, both in terms of its general effects on core excess reactivity and fission power distributions, its effects on the calibration of the core lobe power measurement system, as well as in terms of its own internal fission rate distribution and total fission power per unit ATRC core power. Taken as a whole, these results have significantly extended the ATR physics validation envelope, thereby enabling an entire new class of irradiation experiments.

  1. Elastic image registration to quantify 3-D regional myocardial deformation from volumetric ultrasound: experimental validation in an animal model.

    Science.gov (United States)

    Heyde, Brecht; Bouchez, Stefaan; Thieren, Sabine; Vandenheuvel, Michael; Jasaityte, Ruta; Barbosa, Daniel; Claus, Piet; Maes, Frederik; Wouters, Patrick; D'Hooge, Jan

    2013-09-01

    Although real-time 3-D echocardiography has the potential to allow more accurate assessment of global and regional ventricular dynamics compared with more traditional 2-D ultrasound examinations, it still requires rigorous testing and validation should it break through as a standard examination in routine clinical practice. However, only a limited number of studies have validated 3-D strain algorithms in an in vivo experimental setting. The aim of the present study, therefore, was to validate a registration-based strain estimation methodology in an animal model. Volumetric images were acquired in 14 open-chest sheep instrumented with ultrasonic microcrystals. Radial strain (ɛRR), longitudinal strain (ɛLL) and circumferential strain (ɛCC) were estimated during different stages: at rest, during reduced and increased cardiac inotropy induced by esmolol and dobutamine infusion, respectively, and during acute ischemia. Agreement between image-based and microcrystal-based strain estimates was evaluated by their linear correlation, indicating that all strain components could be estimated with acceptable accuracy (r = 0.69 for ɛRR, r = 0.64 for ɛLL and r = 0.62 for ɛCC). These findings are comparable to the performance of the current state-of-the-art commercial 3-D speckle tracking methods. Furthermore, shape of the strain curves, timing of peak values and location of dysfunctional regions were identified well. Whether 3-D elastic registration performs better than 3-D block matching-based methodologies still remains to be proven. Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  2. Development of Safety Analysis Codes and Experimental Validation for a Very High Temperature Gas-Cooled Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Chang, H. Oh, PhD; Cliff Davis; Richard Moore

    2004-11-01

    The very high temperature gas-cooled reactors (VHTGRs) are those concepts that have average coolant temperatures above 900 degrees C or operational fuel temperatures above 1250 degrees C. These concepts provide the potential for increased energy conversion efficiency and for high-temperature process heat application in addition to power generation and nuclear hydrogen generation. While all the High Temperature Gas Cooled Reactor (HTGR) concepts have sufficiently high temperatures to support process heat applications, such as desalination and cogeneration, the VHTGR's higher temperatures are suitable for particular applications such as thermochemical hydrogen production. However, the high temperature operation can be detrimental to safety following a loss-of-coolant accident (LOCA) initiated by pipe breaks caused by seismic or other events. Following the loss of coolant through the break and coolant depressurization, air from the containment will enter the core by molecular diffusion and ultimately by natural convection, leading to oxidation of the in-core graphite structures and fuel. The oxidation will release heat and accelerate the heatup of the reactor core. Thus, without any effective countermeasures, a pipe break may lead to significant fuel damage and fission product release. The Idaho National Engineering and Environmental Laboratory (INEEL) has investigated this event for the past three years for the HTGR. However, the computer codes used, and in fact none of the world's computer codes, have been sufficiently developed and validated to reliably predict this event. New code development, improvement of the existing codes, and experimental validation are imperative to narrow the uncertaninty in the predictions of this type of accident. The objectives of this Korean/United States collaboration are to develop advanced computational methods for VHTGR safety analysis codes and to validate these computer codes.

  3. Experimental validation of a new sorption refrigerator heated by natural gas; Validacao experimental de um refigerador de sorcao aquecido por gas natural

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Maria E. Vieira da; Medeiros, Marcelo R.Q. [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil); Schwarzer, Klemens [Universidade de Ciencias Aplicadas de Aachen (Germany); Campos, Michel F. [PETROBRAS, Rio de Janeiro, RJ (Brazil)

    2004-07-01

    This article presents the experimental results that validate the operation of a new refrigerator in sorption cycle that uses natural gas as its heat source. The project was financed by the RedeGasEnergia of the Petroleo Brasileiro Company - PETROBRAS and by Brazilian agency Agencia Brasileira Financiadora de Estudos e Projetos - FINEP. The refrigeration cycle has two phases: heating/desorption and cooling/adsorption. The materials used were the zeolite 13X and water. The system components, designed for this project, were: two adsorbers, two burners, one condenser and one evaporator. In the heating phase, the burners were turned on to heat up the adsorbers. The adsorbate was released in the vapor phase e flew to the condenser. After its condensation, the liquid moved by the action of gravity to the evaporator. When the burners were turned off, the adsorbers started to cool down due to natural convection and radiation to the ambient. With the decrease of temperature in the adsorbers, the adsorption process began and temperatures below 0 deg C (ice making) were measured in the evaporator. The equipment showed good thermal performance and temperatures near -4 deg C were measured in the evaporator. To produce 5 kg of ice, 0,123 kg of natural gas was used. (author)

  4. Optimization and experimental validation of stiff porous phononic plates for widest complete bandgap of mixed fundamental guided wave modes

    Science.gov (United States)

    Hedayatrasa, Saeid; Kersemans, Mathias; Abhary, Kazem; Uddin, Mohammad; Van Paepegem, Wim

    2018-01-01

    Phononic crystal plates (PhPs) have promising application in manipulation of guided waves for design of low-loss acoustic devices and built-in acoustic metamaterial lenses in plate structures. The prominent feature of phononic crystals is the existence of frequency bandgaps over which the waves are stopped, or are resonated and guided within appropriate defects. Therefore, maximized bandgaps of PhPs are desirable to enhance their phononic controllability. Porous PhPs produced through perforation of a uniform background plate, in which the porous interfaces act as strong reflectors of wave energy, are relatively easy to produce. However, the research in optimization of porous PhPs and experimental validation of achieved topologies has been very limited and particularly focused on bandgaps of flexural (asymmetric) wave modes. In this paper, porous PhPs are optimized through an efficient multiobjective genetic algorithm for widest complete bandgap of mixed fundamental guided wave modes (symmetric and asymmetric) and maximized stiffness. The Pareto front of optimization is analyzed and variation of bandgap efficiency with respect to stiffness is presented for various optimized topologies. Selected optimized topologies from the stiff and compliant regimes of Pareto front are manufactured by water-jetting an aluminum plate and their promising bandgap efficiency is experimentally observed. An optimized Pareto topology is also chosen and manufactured by laser cutting a Plexiglas (PMMA) plate, and its performance in self-collimation and focusing of guided waves is verified as compared to calculated dispersion properties.

  5. A PFC3D-based numerical simulation of cutting load for lunar rock simulant and experimental validation

    Science.gov (United States)

    Li, Peng; Jiang, Shengyuan; Tang, Dewei; Xu, Bo

    2017-05-01

    For sake of striking a balance between the need of drilling efficiency and the constrains of power budget on the moon, the penetrations per revolution of drill bit are generally limited in the range around 0.1 mm, and besides the geometric angle of the cutting blade need to be well designed. This paper introduces a simulation approach based on PFC3D (particle flow code 3 dimensions) for analyzing the cutting load feature on lunar rock simulant, which is derived from different geometric-angle blades with a small cutting depth. The mean values of the cutting force of five blades in the survey region (four on the boundary points and one on the center point) are selected as the macroscopic responses of model. The method of experimental design which includes Plackett-Burman (PB) design and central composite design (CCD) method is adopted in the matching procedure of microparameters in PFC model. Using the optimization method of enumeration, the optimum set of microparameters is acquired. Then, the experimental validation is implemented by using other twenty-five blades with different geometric angles, and the results from both simulations and laboratory tests give fair agreements. Additionally, the rock breaking process cut by different blades are quantified from simulation analysis. This research provides the theoretical support for the refinement of the rock cutting load prediction and the geometric design of cutting blade on the drill bit.

  6. On the impact of damping on the dispersion curves of a locally resonant metamaterial: Modelling and experimental validation

    Science.gov (United States)

    Belle, Lucas Van; Claeys, Claus; Deckers, Elke; Desmet, Wim

    2017-11-01

    Recently, locally resonant metamaterials have come to the fore in noise and vibration control engineering, showing great potential due to their superior noise and vibration attenuation performance in targeted and tunable frequency ranges, referred to as stop bands. Damping has an important influence on the performance of these materials, broadening the frequency range of attenuation at the expense of peak attenuation. As a result, understanding and including the effects of damping is necessary to more accurately predict the attenuation performance of these locally resonant metamaterials. Classically, these often periodic structures are analysed using a unit cell modelling approach to predict wave propagation and thus stop band behaviour, discarding damping. In this work, a unit cell method including damping is used to analyse the complex dispersion curves of a locally resonant metamaterial design. The wave solutions in and around the stop band frequency range are compared to those of the unit cell method discarding damping. The influence on the dispersion curves of damping in resonator and host structure is discussed and the obtained dispersion curves are validated through an experimental dispersion curve measurement based on an Extended Inhomogeneous Wave Correlation method using Scanning Laser Doppler Vibrometry for a metamaterial plate manufactured at a representative scale. Excellent agreement is obtained between the numerically predicted and experimentally retrieved dispersion curves.

  7. Validation of the generalized model of two-phase thermosyphon loop based on experimental measurements of volumetric flow rate

    Directory of Open Access Journals (Sweden)

    Bieliński Henryk

    2016-09-01

    Full Text Available The current paper presents the experimental validation of the generalized model of the two-phase thermosyphon loop. The generalized model is based on mass, momentum, and energy balances in the evaporators, rising tube, condensers and the falling tube. The theoretical analysis and the experimental data have been obtained for a new designed variant. The variant refers to a thermosyphon loop with both minichannels and conventional tubes. The thermosyphon loop consists of an evaporator on the lower vertical section and a condenser on the upper vertical section. The one-dimensional homogeneous and separated two-phase flow models were used in calculations. The latest minichannel heat transfer correlations available in literature were applied. A numerical analysis of the volumetric flow rate in the steady-state has been done. The experiment was conducted on a specially designed test apparatus. Ultrapure water was used as a working fluid. The results show that the theoretical predictions are in good agreement with the measured volumetric flow rate at steady-state.

  8. Validation of the generalized model of two-phase thermosyphon loop based on experimental measurements of volumetric flow rate

    Science.gov (United States)

    Bieliński, Henryk

    2016-09-01

    The current paper presents the experimental validation of the generalized model of the two-phase thermosyphon loop. The generalized model is based on mass, momentum, and energy balances in the evaporators, rising tube, condensers and the falling tube. The theoretical analysis and the experimental data have been obtained for a new designed variant. The variant refers to a thermosyphon loop with both minichannels and conventional tubes. The thermosyphon loop consists of an evaporator on the lower vertical section and a condenser on the upper vertical section. The one-dimensional homogeneous and separated two-phase flow models were used in calculations. The latest minichannel heat transfer correlations available in literature were applied. A numerical analysis of the volumetric flow rate in the steady-state has been done. The experiment was conducted on a specially designed test apparatus. Ultrapure water was used as a working fluid. The results show that the theoretical predictions are in good agreement with the measured volumetric flow rate at steady-state.

  9. Experimental validation and performance evaluation of OpenFlow-based wavelength path control in transparent optical networks.

    Science.gov (United States)

    Liu, Lei; Tsuritani, Takehiro; Morita, Itsuro; Guo, Hongxiang; Wu, Jian

    2011-12-19

    OpenFlow, as an open-source protocol for network virtualization, is also widely regarded as a promising control plane technique for heterogeneous networks. But the utilization of the OpenFlow protocol to control a wavelength switched optical network has not been investigated. In this paper, for the first time, we experimentally present a proof-of-concept demonstration of OpenFlow-based wavelength path control for lightpath provisioning in transparent optical networks. We propose two different approaches (sequential and delayed approaches) for lightpath setup and two different approaches (active and passive approaches) for lightpath release by using the OpenFlow protocol. The overall feasibility of these approaches is experimentally validated and the network performances are quantitatively evaluated. More importantly, all the proposed methodologies are demonstrated and evaluated on a real transparent optical network testbed with both OpenFlow-based control plane and data plane, which allows their feasibility and effectiveness to be verified, and valuable insights of the proposed solutions to be obtained for deploying into real OpenFlow controlled optical networks.

  10. Development and experimental validation of a nifH oligonucleotide microarray to study diazotrophic communities in a glacier forefield.

    Science.gov (United States)

    Duc, Laurence; Neuenschwander, Stefan; Rehrauer, Hubert; Wagner, Ulrich; Sobek, Jens; Schlapbach, Ralph; Zeyer, Josef

    2009-08-01

    Functional microarrays are powerful tools that allow the parallel detection of multiple strains at the species level and therefore to rapidly obtain information on microbial communities in the environment. However, the design of suitable probes is prone to uncertainties, as it is based so far on in silico predictions including weighted mismatch number and Gibbs free-energy values. This study describes the experimental selection of probes targeting subsequences of the nifH gene to study the community structure of diazotrophic populations present in Damma glacier (Swiss Central Alps) forefield soils. Using the Geniom One in situ synthesis technology (Febit, Germany), 2727 in silico designed candidate probes were tested. A total of 946 specific probes were selected and validated. This probe set covered a large diversity of the NifH phylotypes (35 out of the 45) found in the forefield. Hybridization predictors were tested statistically. Gibbs free-energy value for probe-target binding gave the best prediction for hybridization efficiency, while the weighted mismatch number was not significantly associated to probe specificity. In this study, we demonstrate that extensive experimental tests of probe-hybridization behaviour against sequences present in the studied environment remain a prerequisite for meaningful probe selection.

  11. A two-dimensional effective model describing fluid structure interaction in blood flow: analysis, simulation and experimental validation

    Science.gov (United States)

    Čanić, Sunčica; Mikelić, Andro; Tambača, Josip

    2005-12-01

    We derive a closed system of effective equations describing a time-dependent flow of a viscous incompressible Newtonian fluid through a long and narrow elastic tube. The 3D axially symmetric incompressible Navier-Stokes equations are used to model the flow. Two models are used to describe the tube wall: the linear membrane shell model and the linearly elastic membrane and the curved, linearly elastic Koiter shell model. We study the behavior of the coupled fluid-structure interaction problem in the limit when the ratio between the radius and the length of the tube, ɛ, tends to zero. We obtain the reduced equations that are of Biot type with memory. An interesting feature of the reduced equations is that the memory term explicitly captures the viscoelastic nature of the coupled problem. Our model provides significant improvement over the standard 1D approximations of the fluid-structure interaction problem, all of which assume an ad hoc closure assumption for the velocity profile. We performed experimental validation of the reduced model using a mock circulatory flow loop assembled at the Cardiovascular Research Laboratory at the Texas Heart Institute. Experimental results show excellent agreement with the numerically calculated solution. Major applications include blood flow through large human arteries. To cite this article: S. Čanić et al., C. R. Mecanique 333 (2005).

  12. Experimental validation of contrast-enhanced SSFP cine CMR for quantification of myocardium at risk in acute myocardial infarction.

    Science.gov (United States)

    Nordlund, David; Kanski, Mikael; Jablonowski, Robert; Koul, Sasha; Erlinge, David; Carlsson, Marcus; Engblom, Henrik; Aletras, Anthony H; Arheden, Håkan

    2017-01-30

    Accurate assessment of myocardium at risk (MaR) after acute myocardial infarction (AMI) is necessary when assessing myocardial salvage. Contrast-enhanced steady-state free precession (CE-SSFP) is a recently developed cardiovascular magnetic resonance (CMR) method for assessment of MaR up to 1 week after AMI. Our aim was to validate CE-SSFP for determination of MaR in an experimental porcine model using myocardial perfusion single-photon emission computed tomography (MPS) as a reference standard and to test the stability of MaR-quantification over time after injecting gadolinium-based contrast. Eleven pigs were subjected to either 35 or 40 min occlusion of the left anterior descending artery followed by six hours of reperfusion. A technetium-based perfusion tracer was administered intravenously ten minutes before reperfusion. In-vivo and ex-vivo CE-SSFP CMR was performed followed by ex-vivo MPS imaging. MaR was expressed as % of left ventricular mass (LVM). There was good agreement between MaR by ex-vivo CMR and MaR by MPS (bias: 1 ± 3% LVM, r 2  = 0.92, p myocardial salvage in experimental studies.

  13. Concurrent Reflectance Confocal Microscopy and Laser Doppler Flowmetry to Improve Skin Cancer Imaging: A Monte Carlo Model and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Alireza Mowla

    2016-09-01

    Full Text Available Optical interrogation of suspicious skin lesions is standard care in the management of skin cancer worldwide. Morphological and functional markers of malignancy are often combined to improve expert human diagnostic power. We propose the evaluation of the combination of two independent optical biomarkers of skin tumours concurrently. The morphological modality of reflectance confocal microscopy (RCM is combined with the functional modality of laser Doppler flowmetry, which is capable of quantifying tissue perfusion. To realize the idea, we propose laser feedback interferometry as an implementation of RCM, which is able to detect the Doppler signal in addition to the confocal reflectance signal. Based on the proposed technique, we study numerical models of skin tissue incorporating two optical biomarkers of malignancy: (i abnormal red blood cell velocities and concentrations and (ii anomalous optical properties manifested through tissue confocal reflectance, using Monte Carlo simulation. We also conduct a laboratory experiment on a microfluidic channel containing a dynamic turbid medium, to validate the efficacy of the technique. We quantify the performance of the technique by examining a signal to background ratio (SBR in both the numerical and experimental models, and it is shown that both simulated and experimental SBRs improve consistently using this technique. This work indicates the feasibility of an optical instrument, which may have a role in enhanced imaging of skin malignancies.

  14. A theoretical model of the application of RF energy to the airway wall and its experimental validation

    Directory of Open Access Journals (Sweden)

    Brown Robert H

    2010-11-01

    Full Text Available Abstract Background Bronchial thermoplasty is a novel technique designed to reduce an airway's ability to contract by reducing the amount of airway smooth muscle through controlled heating of the airway wall. This method has been examined in animal models and as a treatment for asthma in human subjects. At the present time, there has been little research published about how radiofrequency (RF energy and heat is transferred to the airways of the lung during bronchial thermoplasty procedures. In this manuscript we describe a computational, theoretical model of the delivery of RF energy to the airway wall. Methods An electro-thermal finite-element-analysis model was designed to simulate the delivery of temperature controlled RF energy to airway walls of the in vivo lung. The model includes predictions of heat generation due to RF joule heating and transfer of heat within an airway wall due to thermal conduction. To implement the model, we use known physical characteristics and dimensions of the airway and lung tissues. The model predictions were tested with measurements of temperature, impedance, energy, and power in an experimental canine model. Results Model predictions of electrode temperature, voltage, and current, along with tissue impedance and delivered energy were compared to experiment measurements and were within ± 5% of experimental averages taken over 157 sample activations. The experimental results show remarkable agreement with the model predictions, and thus validate the use of this model to predict the heat generation and transfer within the airway wall following bronchial thermoplasty. Conclusions The model also demonstrated the importance of evaporation as a loss term that affected both electrical measurements and heat distribution. The model predictions showed excellent agreement with the empirical results, and thus support using the model to develop the next generation of devices for bronchial thermoplasty. Our results suggest

  15. Crack Detection in Fibre Reinforced Plastic Structures Using Embedded Fibre Bragg Grating Sensors: Theory, Model Development and Experimental Validation.

    Directory of Open Access Journals (Sweden)

    G F Pereira

    Full Text Available In a fibre-reinforced polymer (FRP structure designed using the emerging damage tolerance and structural health monitoring philosophy, sensors and models that describe crack propagation will enable a structure to operate despite the presence of damage by fully exploiting the material's mechanical properties. When applying this concept to different structures, sensor systems and damage types, a combination of damage mechanics, monitoring technology, and modelling is required. The primary objective of this article is to demonstrate such a combination. This article is divided in three main topics: the damage mechanism (delamination of FRP, the structural health monitoring technology (fibre Bragg gratings to detect delamination, and the finite element method model of the structure that incorporates these concepts into a final and integrated damage-monitoring concept. A novel method for assessing a crack growth/damage event in fibre-reinforced polymer or structural adhesive-bonded structures using embedded fibre Bragg grating (FBG sensors is presented by combining conventional measured parameters, such as wavelength shift, with parameters associated with measurement errors, typically ignored by the end-user. Conjointly, a novel model for sensor output prediction (virtual sensor was developed using this FBG sensor crack monitoring concept and implemented in a finite element method code. The monitoring method was demonstrated and validated using glass fibre double cantilever beam specimens instrumented with an array of FBG sensors embedded in the material and tested using an experimental fracture procedure. The digital image correlation technique was used to validate the model prediction by correlating the specific sensor response caused by the crack with the developed model.

  16. Experimental validation of the AVIVET trap, a tool to quantitatively monitor the dynamics of Dermanyssus gallinae populations in laying hens.

    Science.gov (United States)

    Lammers, G A; Bronneberg, R G G; Vernooij, J C M; Stegeman, J A

    2017-06-01

    Dermanyssus gallinae (D.gallinae) infestation causes economic losses due to impaired health and production of hens and costs of parasite control across the world. Moreover, infestations are associated with reduced welfare of hens and may cause itching in humans. To effectively implement control methods it is crucially important to have high quality information about the D.gallinae populations in poultry houses in space and time. At present no validated tool is available to quantitatively monitor the dynamics of all four stages of D.gallinae (i.e., eggs, larvae, nymphs, and adults) in poultry houses.This article describes the experimental validation of the AVIVET trap, a device to quantitatively monitor dynamics of D.gallinae infestations. We used the device to study D.gallinae in fully equipped cages with two white specific pathogen free Leghorn laying hens experimentally exposed to three different infestation levels of D.gallinae (low to high).The AVIVET trap was successfully able to detect D.gallinae at high (5,000 D.gallinae), medium (2,500 D.gallinae), and low (50 D.gallinae) level of D.gallinae infestation. The linear equation Y = 10∧10∧(0.47 + 1.21X) with Y = log10 (Total number of D.gallinae nymphs and adults) in the cage and X = log10 (Total number of D.gallinae nymphs and adults) in the AVIVET trap explained 93.8% of the variation.The weight of D.gallinae in the AVIVET trap also appears to be a reliable parameter for quantifying D.gallinae infestation in a poultry house. The weight of D.gallinae in the AVIVET trap correlates 99.6% (P < 0.000) to the counted number of all stages of D.gallinae in the trap (i.e., eggs, larvae, nymphs, and adults) indicating that the trap is highly specific.From this experiment it can be concluded that the AVIVET trap is promising as quantitative tool for monitoring D.gallinae dynamics in a poultry house. © 2016 Poultry Science Association Inc.

  17. A primer of special relativity

    CERN Document Server

    Sardesai, PL

    2004-01-01

    A Primer of Special Relativity1 is an unusually lucid introduction to the subject specifically written for Indian students. It is intended to give the beginner a firm grounding for a more advanced course in relativity. An entire chapter is devoted to applications of the theory to elucidate a large number of topics the students (B.Sc. Physics) come across in Modern Physics. Detailed and well-selected examples are used to illuminate aspects of the theory as well as to show techniques of application. A large number of Illustrative Examples enables the students to gain confidence to solve any problem in relativity normally expected of B.Sc. students.

  18. A primer of multivariate statistics

    CERN Document Server

    Harris, Richard J

    2014-01-01

    Drawing upon more than 30 years of experience in working with statistics, Dr. Richard J. Harris has updated A Primer of Multivariate Statistics to provide a model of balance between how-to and why. This classic text covers multivariate techniques with a taste of latent variable approaches. Throughout the book there is a focus on the importance of describing and testing one's interpretations of the emergent variables that are produced by multivariate analysis. This edition retains its conversational writing style while focusing on classical techniques. The book gives the reader a feel for why

  19. Sample Return Primer and Handbook

    Science.gov (United States)

    Barrow, Kirk; Cheuvront, Allan; Faris, Grant; Hirst, Edward; Mainland, Nora; McGee, Michael; Szalai, Christine; Vellinga, Joseph; Wahl, Thomas; Williams, Kenneth; hide

    2007-01-01

    This three-part Sample Return Primer and Handbook provides a road map for conducting the terminal phase of a sample return mission. The main chapters describe element-by-element analyses and trade studies, as well as required operations plans, procedures, contingencies, interfaces, and corresponding documentation. Based on the experiences of the lead Stardust engineers, the topics include systems engineering (in particular range safety compliance), mission design and navigation, spacecraft hardware and entry, descent, and landing certification, flight and recovery operations, mission assurance and system safety, test and training, and the very important interactions with external support organizations (non-NASA tracking assets, landing site support, and science curation).

  20. A primer of Lebesgue integration

    CERN Document Server

    Bear, H S

    2001-01-01

    The Lebesgue integral is now standard for both applications and advanced mathematics. This books starts with a review of the familiar calculus integral and then constructs the Lebesgue integral from the ground up using the same ideas. A Primer of Lebesgue Integration has been used successfully both in the classroom and for individual study.Bear presents a clear and simple introduction for those intent on further study in higher mathematics. Additionally, this book serves as a refresher providing new insight for those in the field. The author writes with an engaging, commonsense style that appeals to readers at all levels.

  1. ULiAS 4 - Experimental validation of a software that models ultrasonic wave propagation through an anisotropic weld

    Energy Technology Data Exchange (ETDEWEB)

    Wirdelius, Haakan; Persson, Gert; Hamberg, Kenneth (SCeNDT, Chalmers Univ. Of Tech., SE-412 96 Goeteborg (SE)); Hoegberg, Kjell (SQC Kvalificeringscentrum AB, SE-183 25 Taeby (SE))

    2008-07-01

    New and stronger demands on reliability of used NDE/NDT procedures and methods have evolved in Europe during the last decade. In order to elaborate these procedures, efforts have to be taken towards the development of mathematical models of applied NDT methods. Modelling of ultrasonic non-destructive testing is useful for a number of reasons, e.g. physical understanding, parametric studies, and the qualification of procedures and personnel. An important issue regarding all models is the validation, i.e. securing that the results of the model and the corresponding computer programs are correct. This can be accomplished by comparisons with other models, but ultimately by comparisons with experiments. In this study a numerical model and experimental results are compared and the work has been performed in collaboration with SQC Kvalificeringscentrum AB. Four different welds have been investigated to give basic data to a mathematical model that describes the ultra sonic wave paths through the welds in these materials. The welds are made in austenitic stainless steel (type 18-8) and in Inconel 182. Two cuts outs are made in each weld, one longitudinal and one transversal cut across the welds, in order to determine the material orientation. In the numerical model the incident field, described by rays, is given by a P wave probe model. The ray tracing technique is based on geometrical optics and a 2D algorithm has been developed. The model of the weld is based on a relatively primitive assumption of the grain structure for a V-butt weld. The columnar structure of austenitic welds is here modelled as a weld where each sub region corresponds to a grain group. The response of the receiver is calculated according to Auld's reciprocity principle. UT data collection was performed by SQC according to guidelines given from Chalmers. The purpose to collect data from real inspection objects with known material structure is to compare experimental data with theoretically

  2. Experimental calibration and validation of sewer/surface flow exchange equations in steady and unsteady flow conditions

    Science.gov (United States)

    Rubinato, Matteo; Martins, Ricardo; Kesserwani, Georges; Leandro, Jorge; Djordjević, Slobodan; Shucksmith, James

    2017-09-01

    The linkage between sewer pipe flow and floodplain flow is recognised to induce an important source of uncertainty within two-dimensional (2D) urban flood models. This uncertainty is often attributed to the use of empirical hydraulic formulae (the one-dimensional (1D) weir and orifice steady flow equations) to achieve data-connectivity at the linking interface, which require the determination of discharge coefficients. Because of the paucity of high resolution localised data for this type of flows, the current understanding and quantification of a suitable range for those discharge coefficients is somewhat lacking. To fulfil this gap, this work presents the results acquired from an instrumented physical model designed to study the interaction between a pipe network flow and a floodplain flow. The full range of sewer-to-surface and surface-to-sewer flow conditions at the exchange zone are experimentally analysed in both steady and unsteady flow regimes. Steady state measured discharges are first analysed considering the relationship between the energy heads from the sewer flow and the floodplain flow; these results show that existing weir and orifice formulae are valid for describing the flow exchange for the present physical model, and yield new calibrated discharge coefficients for each of the flow conditions. The measured exchange discharges are also integrated (as a source term) within a 2D numerical flood model (a finite volume solver to the 2D Shallow Water Equations (SWE)), which is shown to reproduce the observed coefficients. This calibrated numerical model is then used to simulate a series of unsteady flow tests reproduced within the experimental facility. Results show that the numerical model overestimated the values of mean surcharge flow rate. This suggests the occurrence of additional head losses in unsteady conditions which are not currently accounted for within flood models calibrated in steady flow conditions.

  3. Numerical prediction of fiber orientation in injection-molded short-fiber/thermoplastic composite parts with experimental validation

    Energy Technology Data Exchange (ETDEWEB)

    Thi, Thanh Binh Nguyen; Morioka, Mizuki; Yokoyama, Atsushi [Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585 (Japan); Hamanaka, Senji; Yamashita, Katsuhisa; Nonomura, Chisato [Research Center, Toyobo Co., LTD, 2-1-1 Katata, Otsu, Shiga 520-0292 (Japan)

    2015-05-22

    Numerical prediction of the fiber orientation in the short-glass fiber (GF) reinforced polyamide 6 (PA6) composites with the fiber weight concentration of 30%, 50%, and 70% manufactured by the injection molding process is presented. And the fiber orientation was also directly observed and measured through X-ray computed tomography. During the injection molding process of the short-fiber/thermoplastic composite, the fiber orientation is produced by the flow states and the fiber-fiber interaction. Folgar and Tucker equation is the well known for modeling the fiber orientation in a concentrated suspension. They included into Jeffrey’s equation a diffusive type of term by introducing a phenomenological coefficient to account for the fiber-fiber interaction. Our developed model for the fiber-fiber interaction was proposed by modifying the rotary diffusion term of the Folgar-Tucker equation. This model was presented in a conference paper of the 29{sup th} International Conference of the Polymer Processing Society published by AIP conference proceeding. For modeling fiber interaction, the fiber dynamic simulation was introduced in order to obtain a global fiber interaction coefficient, which is sum function of the fiber concentration, aspect ratio, and angular velocity. The fiber orientation is predicted by using the proposed fiber interaction model incorporated into a computer aided engineering simulation package C-Mold. An experimental program has been carried out in which the fiber orientation distribution has been measured in 100 x 100 x 2 mm injection-molded plate and 100 x 80 x 2 mm injection-molded weld by analyzed with a high resolution 3D X-ray computed tomography system XVA-160α, and calculated by X-ray computed tomography imaging. The numerical prediction shows a good agreement with experimental validation. And the complex fiber orientation in the injection-molded weld was investigated.

  4. Characterization and experimental validation of a squeeze film damper with MR fluid in a rotor-bearing system

    Science.gov (United States)

    Dominguez-Nuñez, L. A.; Silva-Navarro, G.

    2014-04-01

    The general study and applications of Magneto-Rhelogical (MR) dampers have been spread in the lasts years but only some studies have been focusing on the vibration control problems on rotor-bearings systems. Squeeze-Film Dampers (SFD) are now commonly used to passively control the vibration response on rotor-bearing systems because they can provide flexibility, damping and extend the so-called stability thresholds in rotating machinery. More recently, SFD are combined with MR or Electro-Rheological (ER) fluids to introduce a semiactive control mechanism to modify the rotordynamic coefficients and deal with the robust performance of the overall system response for higher operating speeds. There are, however, some theoretical and technological problems that complicate their extensive use, like the relationship between the centering spring flexibility and the rheological behavior of the smart fluid to produce the SFD forces. In this work it is considered a SFD with MR fluid and a set of circular section beams in a squirrel cage arrangement in combination with latex seals as centering springs. The mathematical model analysis includes the controllable viscoelastic properties associated to the MR fluid. The characterization of the SFD is made by the determination of some coefficients associated with a modified Choi-Lee-Park polynomial model. During the analysis is considered a rotor-bearing system modeled using finite element methods. The SFD with MR fluid is connected to an experimental platform to validate and experimentally evaluate the overall system. Finally, to improve the open-loop system performance, a methodology for the use of different control schemes is proposed.

  5. On the experimental validation of model-based dose calculation algorithms for 192Ir HDR brachytherapy treatment planning

    Science.gov (United States)

    Pappas, Eleftherios P.; Zoros, Emmanouil; Moutsatsos, Argyris; Peppa, Vasiliki; Zourari, Kyveli; Karaiskos, Pantelis; Papagiannis, Panagiotis

    2017-05-01

    There is an acknowledged need for the design and implementation of physical phantoms appropriate for the experimental validation of model-based dose calculation algorithms (MBDCA) introduced recently in 192Ir brachytherapy treatment planning systems (TPS), and this work investigates whether it can be met. A PMMA phantom was prepared to accommodate material inhomogeneities (air and Teflon), four plastic brachytherapy catheters, as well as 84 LiF TLD dosimeters (MTS-100M 1  ×  1  ×  1 mm3 microcubes), two radiochromic films (Gafchromic EBT3) and a plastic 3D dosimeter (PRESAGE). An irradiation plan consisting of 53 source dwell positions was prepared on phantom CT images using a commercially available TPS and taking into account the calibration dose range of each detector. Irradiation was performed using an 192Ir high dose rate (HDR) source. Dose to medium in medium, Dmm , was calculated using the MBDCA option of the same TPS as well as Monte Carlo (MC) simulation with the MCNP code and a benchmarked methodology. Measured and calculated dose distributions were spatially registered and compared. The total standard (k  =  1) spatial uncertainties for TLD, film and PRESAGE were: 0.71, 1.58 and 2.55 mm. Corresponding percentage total dosimetric uncertainties were: 5.4-6.4, 2.5-6.4 and 4.85, owing mainly to the absorbed dose sensitivity correction and the relative energy dependence correction (position dependent) for TLD, the film sensitivity calibration (dose dependent) and the dependencies of PRESAGE sensitivity. Results imply a LiF over-response due to a relative intrinsic energy dependence between 192Ir and megavoltage calibration energies, and a dose rate dependence of PRESAGE sensitivity at low dose rates (required for the full characterization of dosimeter response for 192Ir and the reduction of experimental uncertainties.

  6. Interaction of 1.319 μm laser with skin: an optical-thermal-damage model and experimental validation

    Science.gov (United States)

    Jiao, Luguang; Yang, Zaifu; Wang, Jiarui

    2014-09-01

    With the widespread use of high-power laser systems operating within the wavelength region of approximately 1.3 to 1.4 μm, it becomes very necessary to refine the laser safety guidelines setting the exposure limits for the eye and skin. In this paper, an optical-thermal-damage model was developed to simulate laser propagation, energy deposition, heat transfer and thermal damage in the skin for 1.319 μm laser irradiation. Meanwhile, an experiment was also conducted in vitro to measure the tempreture history of a porcine skin specimen irradiated by a 1.319 μm laser. Predictions from the model included light distribution in the skin, temperature response and thermal damge level of the tissue. It was shown that the light distribution region was much larger than that of the incident laser at the wavelength of 1.319 μm, and the maximum value of the fluence rate located on the interior region of the skin, not on the surface. By comparing the calculated temperature curve with the experimentally recorded temperautre data, good agreement was shown betweeen them, which validated the numerical model. The model also indicated that the damage integral changed little when the temperature of skin tissue was lower than about 55 °C, after that, the integral increased rapidly and denatunation of the tissue would occur. Based on this model, we can further explore the damage mechanisms and trends for the skin and eye within the wavelength region of 1.3 μm to 1.4 μm, incorporating with in vivo experimental investigations.

  7. Design and experimental validation of the inlet guide vane system of a mini hydraulic bulb-turbine

    Energy Technology Data Exchange (ETDEWEB)

    Ferro, L.M.C. [Department of Mechanical Engineering, Escola Superior de Tecnologia de Setubal, Polytechnic Institute of Setubal, Campus do IPS, Estefanilha, 2910-761 Setubal (Portugal); IDMEC, Instituto Superior Tecnico, Technical University of Lisbon, Av. Rovisco Pais,1049-001 Lisboa (Portugal); Gato, L.M.C.; Falcao, A.F.O. [IDMEC, Instituto Superior Tecnico, Technical University of Lisbon, Av. Rovisco Pais,1049-001 Lisboa (Portugal)

    2010-09-15

    The paper presents a fast design method for the inlet guide vanes of low-cost mini hydraulic bulb turbines. The guide vanes are positioned between two conical surfaces with a common vertex and have constant thickness distribution, except close to the leading and the trailing edges. The conical-walled inlet guide vane row is designed using a quasi-three-dimensional calculation method, by prescribing the angular-momentum distribution along the span at the outlet section of the guide vanes. The meridional through-flow is computed by a streamline curvature method and the blade-to-blade flow by a singularity surface method. The stagger angle and the vane camber are computed to fulfil the required design circulation and zero-incidence flow at the leading edge. The final vane shape is a single-curvature surface with straight leading and trailing edges. To validate the design method, a conical-walled inlet guide vane row nozzle-model with six fixed vanes was designed, manufactured and tested in an airflow rig. Traversing measurements along the circumferential and radial directions were made with a five-hole probe. The experimental results are compared with the prescribed design conditions and with numerical results from the three-dimensional inviscid and viscous flow computed with the FLUENT code. (author)

  8. Theoretical research and experimental validation of elastic dynamic load spectra on bogie frame of high-speed train

    Science.gov (United States)

    Zhu, Ning; Sun, Shouguang; Li, Qiang; Zou, Hua

    2016-05-01

    When a train runs at high speeds, the external exciting frequencies approach the natural frequencies of bogie critical components, thereby inducing strong elastic vibrations. The present international reliability test evaluation standard and design criteria of bogie frames are all based on the quasi-static deformation hypothesis. Structural fatigue damage generated by structural elastic vibrations has not yet been included. In this paper, theoretical research and experimental validation are done on elastic dynamic load spectra on bogie frame of high-speed train. The construction of the load series that correspond to elastic dynamic deformation modes is studied. The simplified form of the load series is obtained. A theory of simplified dynamic load-time histories is then deduced. Measured data from the Beijing-Shanghai Dedicated Passenger Line are introduced to derive the simplified dynamic load-time histories. The simplified dynamic discrete load spectra of bogie frame are established. Based on the damage consistency criterion and a genetic algorithm, damage consistency calibration of the simplified dynamic load spectra is finally performed. The computed result proves that the simplified load series is reasonable. The calibrated damage that corresponds to the elastic dynamic discrete load spectra can cover the actual damage at the operating conditions. The calibrated damage satisfies the safety requirement of damage consistency criterion for bogie frame. This research is helpful for investigating the standardized load spectra of bogie frame of high-speed train.

  9. Fuzzy structure theory modeling of sound-insulation layers in complex vibroacoustic uncertain systems: theory and experimental validation.

    Science.gov (United States)

    Fernandez, Charles; Soize, Christian; Gagliardini, Laurent

    2009-01-01

    The fuzzy structure theory was introduced 20 years ago in order to model the effects of complex subsystems imprecisely known on a master structure. This theory was only aimed at structural dynamics. In this paper, an extension of that theory is proposed in developing an elastoacoustic element useful to model sound-insulation layers for computational vibroacoustics of complex systems. The simplified model constructed enhances computation time and memory allocation because the number of physical and generalized degrees of freedom in the computational vibroacoustic model is not increased. However, these simplifications introduce model uncertainties. In order to take into account these uncertainties, the nonparametric probabilistic approach recently introduced is used. A robust simplified model for sound-insulation layers is then obtained. This model is controlled by a small number of physical and dispersion parameters. First, the extension of the fuzzy structure theory to elastoacoustic element is presented. Second, the computational vibroacoustic model including such an elastoacoustic element to model sound-insulation layer is given. Then, a design methodology to identify the model parameters with experiments is proposed and is experimentally validated. Finally, the theory is applied to an uncertain vibroacoustic system.

  10. Modeling, construction and experimental validation of actuated rolling dynamics of the cylindrical Transforming Roving-Rolling Explorer (TRREx)

    Science.gov (United States)

    Edwin, L.; Mazzoleni, A.; Gemmer, T.; Ferguson, S.

    2017-03-01

    Planetary surface exploration technology over the past few years has seen significant advancements on multiple fronts. Robotic exploration platforms are becoming more sophisticated and capable of embarking on more challenging missions. More unconventional designs, particularly transforming architectures that have multiple modes of locomotion, are being studied. This work explores the capabilities of one such novel transforming rover called the Transforming Roving-Rolling Explorer (TRREx). Biologically inspired by the armadillo and the golden-wheel spider, the TRREx has two modes of locomotion: it can traverse on six wheels like a conventional rover on benign terrain, but can transform into a sphere when necessary to negotiate steep rugged slopes. The ability to self-propel in the spherical configuration, even in the absence of a negative gradient, increases the TRREx's versatility and its concept value. This paper describes construction and testing of a prototype cylindrical TRREx that demonstrates that "actuated rolling" can be achieved, and also presents a dynamic model of this prototype version of the TRREx that can be used to investigate the feasibility and value of such self-propelled locomotion. Finally, we present results that validate our dynamic model by comparing results from computer simulations made using the dynamic model to experimental results acquired from test runs using the prototype.

  11. Systematic Design Method and Experimental Validation of a 2-DOF Compliant Parallel Mechanism with Excellent Input and Output Decoupling Performances

    Directory of Open Access Journals (Sweden)

    Yao Jiang

    2017-06-01

    Full Text Available The output and input coupling characteristics of the compliant parallel mechanism (CPM bring difficulty in the motion control and challenge its high performance and operational safety. This paper presents a systematic design method for a 2-degrees-of-freedom (DOFs CPM with excellent decoupling performance. A symmetric kinematic structure can guarantee a CPM with a complete output decoupling characteristic; input coupling is reduced by resorting to a flexure-based decoupler. This work discusses the stiffness design requirement of the decoupler and proposes a compound flexure hinge as its basic structure. Analytical methods have been derived to assess the mechanical performances of the CPM in terms of input and output stiffness, motion stroke, input coupling degree, and natural frequency. The CPM’s geometric parameters were optimized to minimize the input coupling while ensuring key performance indicators at the same time. The optimized CPM’s performances were then evaluated by using a finite element analysis. Finally, a prototype was constructed and experimental validations were carried out to test the performance of the CPM and verify the effectiveness of the design method. The design procedure proposed in this paper is systematic and can be extended to design the CPMs with other types of motion.

  12. Testing the validity of the Danish urban myth that alcohol can be absorbed through feet: open labelled self experimental study

    Science.gov (United States)

    Hansen, Christian Stevns; Færch, Louise Holmsgaard

    2010-01-01

    Objective To determine the validity of the Danish urban myth that it is possible to get drunk by submerging feet in alcohol. Design Open labelled, self experimental study, with no control group. Setting Office of a Danish hospital. Participants Three adults, median age 32 (range 31-35), free of chronic skin and liver disease and non-dependent on alcohol and psychoactive drugs. Main outcome measures The primary end point was the concentration of plasma ethanol (detection limit 2.2 mmol/L (10 mg/100 mL)), measured every 30 minutes for three hours while feet were submerged in a washing-up bowl containing the contents of three 700 mL bottles of vodka. The secondary outcome was self assessment of intoxication related symptoms (self confidence, urge to speak, and number of spontaneous hugs), scored on a scale of 0 to 10. Results Plasma ethanol concentrations were below the detection limit of 2.2 mmol/L (10 mg/100 mL) throughout the experiment. No significant changes were observed in the intoxication related symptoms, although self confidence and urge to speak increased slightly at the start of the study, probably due to the setup. Conclusion Our results suggest that feet are impenetrable to the alcohol component of vodka. We therefore conclude that the Danish urban myth of being able to get drunk by submerging feet in alcoholic beverages is just that; a myth. The implications of the study are many though. PMID:21156749

  13. Development and Experimental Validation of a Numerical Tool for Structural Health and Usage Monitoring Systems Based on Chirped Grating Sensors

    Directory of Open Access Journals (Sweden)

    Paolo Bettini

    2015-01-01

    Full Text Available The interest of the aerospace industries in structural health and usage monitoring systems is continuously increasing. Among the techniques available in literature those based on Fibre Bragg Grating sensors are much promising thanks to their peculiarities. Different Chirped Bragg Grating sensor configurations have been investigated in this paper. Starting from a numerical model capable of simulating the spectral response of a grating subjected to a generic strain profile (direct problem, a new code has been developed, allowing strain reconstruction from the experimental validation of the program, carried out through different loading cases applied on a chirped grating. The wavelength of the reflection spectrum for a chirped FBG has a one-to-one correspondence to the position along the gauge section, thus allowing strain reconstruction over the entire sensor length. Tests conducted on chirped FBGs also evidenced their potential for SHM applications, if coupled with appropriate numerical strain reconstructions tools. Finally, a new class of sensors—Draw Tower Grating arrays—has been studied. These sensors are applicable to distributed sensing and load reconstruction over large structures, thanks to their greater length. Three configurations have been evaluated, having different spatial and spectral characteristics, in order to explore possible applications of such sensors to SHM systems.

  14. Development and experimental validation of a numerical tool for structural health and usage monitoring systems based on chirped grating sensors.

    Science.gov (United States)

    Bettini, Paolo; Guerreschi, Erika; Sala, Giuseppe

    2015-01-12

    The interest of the aerospace industries in structural health and usage monitoring systems is continuously increasing. Among the techniques available in literature those based on Fibre Bragg Grating sensors are much promising thanks to their peculiarities. Different Chirped Bragg Grating sensor configurations have been investigated in this paper. Starting from a numerical model capable of simulating the spectral response of a grating subjected to a generic strain profile (direct problem), a new code has been developed, allowing strain reconstruction from the experimental validation of the program, carried out through different loading cases applied on a chirped grating. The wavelength of the reflection spectrum for a chirped FBG has a one-to-one correspondence to the position along the gauge section, thus allowing strain reconstruction over the entire sensor length. Tests conducted on chirped FBGs also evidenced their potential for SHM applications, if coupled with appropriate numerical strain reconstructions tools. Finally, a new class of sensors-Draw Tower Grating arrays-has been studied. These sensors are applicable to distributed sensing and load reconstruction over large structures, thanks to their greater length. Three configurations have been evaluated, having different spatial and spectral characteristics, in order to explore possible applications of such sensors to SHM systems.

  15. Control Structure Impact on the Flying Performance of the Multi-Rotor VTOL Platform - Design, Analysis and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Roman Czyba

    2013-01-01

    Full Text Available The aim of this research is to examine the different control strategies for the unmanned aerial vehicles (UAV. The control task is formulated as an angular stabilization of the four rotor platform, and also as a tracking problem of chosen state variables. The PID algorithm has been considered in three structures in respect of the optimal control signal applied to the actuators. For better performance of the quadrotor in hover mode the cascade control system has been proposed. The simulation results of attitude control with different PID controller architectures are presented, and confirm the effectiveness of the proposed control structure and theoretical expectations. Moreover, the design and the practical realization of the control architecture on the experimental aerial vehicle are described. The fast prototyping method together with Matlab/Simulink software and DAQ hardware are used for both evolution and validation of control algorithms. The capacity of the attitude stabilization system is important in the development process of more advanced functionality of autonomous flying vehicles; therefore it needs to be highlighted and taken into careful consideration.

  16. The Development and Full-Scale Experimental Validation of an Optimal Water Treatment Solution in Improving Chiller Performances

    Directory of Open Access Journals (Sweden)

    Chen-Yu Chiang

    2016-06-01

    Full Text Available An optimal solution, in combining physical and chemical water treatment methods, has been developed. This method uses a high voltage capacitance based (HVCB electrodes, coupled with biocides to form a sustainable solution in improving chiller plant performances. In this study, the industrial full-scale tests, instead of laboratory tests, have been conducted on chiller plants at the size of 5000 RT to 10,000 RT cooling capacities under commercial operation for more than two years. The experimental results indicated that the condenser approach temperatures can be maintained at below 1 °C for over two years. It has been validated that the coefficient of performance (COP of a chiller can be improved by over 5% by implementing this solution. Every 1 °C reduction in condenser approach temperature can yield approximately 3% increase on chiller COP, which warrants its future application potential in the HVAC industry, where Ta can degrade by 1 °C every three to six months. The solution developed in this study could also reduce chemical dosages and conserve makeup water substantially and is more environment friendly.

  17. Experimental validation of calculations of decay heat induced by 14 MeV neutron activation of ITER materials

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, N.P.; Bartels, H.-W.; Saji, G. [ITER Joint Central Team, San Diego, La Jolla (United States); Ikeda, Y.; Maekawa, F. [Japan Atomic Energy Research Institute, Tokai-mura (Japan); Cambi, G. [Physics Department, Bologna University, Bologna (Italy); Cepraga, D.G. [ENEA, INN-FIS-MACO, Bologna (Italy); Cheng, E.T. [TSI Research Inc., Solana Beach, CA (United States); Forrest, R.A.; Sublet, J.-C. [Euratom/UKAEA Fusion Association, Culham Science Centre, Abingdon, Oxfordshire OX14 3DB (United Kingdom); Iida, H.; Santoro, R.T. [ITER Joint Central Team, Garching (Germany); Khater, H.Y.; Sawan, M.E. [Fusion Technology Institute, University of Wisconsin, Madison, WI (United States); Youssef, M.Z. [Mechanical and Aerospace Engineering Department, University of California at Los Angeles, Los Angeles, CA (United States)

    1999-03-01

    In a D-T fusion tokamak, neutron activation of structural material will result in a source of heat from radioactive decay after shutdown of the plasma. Although relatively small, in certain postulated loss-of-cooling accidents this decay heat could drive a temperature transient of modest proportions. In safety studies of the International Thermonuclear Experimental Reactor (ITER), such accident scenarios are analysed for their possible consequences, requiring an accurate knowledge of the level and time-dependence of the decay heat in components in which it is significant. This is calculated by activation modelling using computer codes with libraries of nuclear data. This paper describes an international benchmark activity to validate several of these codes and data, using the results of direct measurements of decay heat in ITER-relevant materials after exposure to a flux of 14 MeV neutrons. The results show consistency between the codes and, when using data from the recently-compiled FENDL/A-2 activation data library, good agreement with the experiments over the time-scales of interest in ITER safety studies. (orig.) 24 refs.

  18. Kinetics study of solid ammonia borane hydrogen release--modeling and experimental validation for chemical hydrogen storage.

    Science.gov (United States)

    Choi, Young Joon; Rönnebro, Ewa C E; Rassat, Scot; Karkamkar, Abhi; Maupin, Gary; Holladay, Jamie; Simmons, Kevin; Brooks, Kriston

    2014-05-07

    Ammonia borane (AB), NH3BH3, is a promising material for chemical hydrogen storage with 19.6 wt% gravimetric hydrogen capacity of which maximum 16.2 wt% hydrogen can be released via an exothermic thermal decomposition below 200 °C. We have investigated the kinetics of hydrogen release from AB and from an AB-methyl cellulose (AB/MC) composite at temperatures of 160-300 °C using both experiments and modeling. The hydrogen release rate at 300 °C is twice as fast as at 160 °C. The purpose of our study was to show safe hydrogen release without thermal runaway effects and to validate system model kinetics. AB/MC released hydrogen at ∼20 °C lower than neat AB and at a faster release rate in that temperature range. Based on the experimental results, the kinetics equations were revised to better represent the growth and nucleation process during decomposition of AB. We explored two different reactor concepts; auger and fixed bed. The current auger reactor concept turned out to not be appropriate, however, we demonstrated safe self-propagation of the hydrogen release reaction of solid AB/MC in a fixed bed reactor.

  19. Kinetics Study of Solid Ammonia Borane Hydrogen Release – Modeling and Experimental Validation for Chemical Hydrogen Storage

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Yong-Joon; Ronnebro, Ewa; Rassat, Scot D.; Karkamkar, Abhijeet J.; Maupin, Gary D.; Holladay, Jamelyn D.; Simmons, Kevin L.; Brooks, Kriston P.

    2014-02-24

    Ammonia borane (AB), NH3BH3, is a promising material for chemical hydrogen storage with 19.6 wt% gravimetric hydrogen capacity of which 16.2 wt% hydrogen can be utilized below 200°C. We have investigated the kinetics of hydrogen release from AB and from an AB-methyl cellulose (AB/MC) composite at temperatures of 160-300°C using both experiments and modeling. The purpose of our study was to show safe hydrogen release without thermal runaway effects and to validate system model kinetics. AB/MC released hydrogen at ~20°C lower than neat AB and at a rate that is two times faster. Based on the experimental results, the kinetics equations were revised to better represent the growth and nucleation process during decomposition of AB. We explored two different reactor concepts; Auger and fixed bed. The current Auger reactor concept turned out to not be appropriate, however, we demonstrated safe self-propagation of the hydrogen release reaction of solid AB/MC in a fixed bed reactor.

  20. Validation of the ovine fetus as an experimental model for the human myelomeningocele defect: a pilot study

    Directory of Open Access Journals (Sweden)

    Denise Araujo Lapa Pedreira

    2006-09-01

    Full Text Available Objective: To produce a myelomeningocele-like human defect inthe ovine fetus and validate this experimental model in ourpopulation. Methods: A prospective study on 12 pregnant sheep ofa crossed Hampshire/Down breed where a spinal defect wassurgically created between day 75 and day 77 after conception.The technique consisted of a hysterotomy with exposure of fetalhind limbs and tail up to the mid spine. Fetal skin, paravertebralmuscles, and 4 posterior spinal arches were excised, exposingthe spinal cord. Duramater was opened and the medulla was inciseduntil the medullar canal. Animals were euthanized at 139 days ofgestation for fetal evaluation. The central nervous system wassubmitted to post-mortem magnetic resonance imaging (MRI andthe spine was submitted to pathological examination. Results:The defect was created in 13 fetuses and 5 survived. Meangestational age at necropsy was 121.6 days (varying from 93 to145 days. Macroscopically, the defect was present in 4 cases.Microscopy revealed a flattened medulla with disappearance ofthe medullar canal and disruption of normal medullar cellarchitecture with neuronal apoptosis and/or fusion of the piamaterand duramater. The MRI showed herniation of the cerebellum intothe cervical canal and syringomyelia. Conclusions: The surgicallyproduced defect mimics defects in the human fetus, including theArnold-Chiari malformation. Post-mortem MRI was used for thefirst time in our study and proved an excellent alternative fordemonstrating the cerebellar herniation. We standardized thetechnique for creating the defect in our population.